Effects of XXXX on perceptual and mechanical responses to bronchoconstriction in @entity565 .

@entity28 @entity1353 @entity565 @entity358 @entity1576 @entity2710
RATIONALE: The influence of @entity28 on the perception of respiratory discomfort during acute bronchoconstriction in @entity565 is unknown. OBJECTIVES: We hypothesized that the @entity1576 associated with an increased body mass index (BMI) would predispose to greater perceived symptom intensity during acute airway narrowing. We therefore compared relationships between induced changes in @entity1353 intensity and lung function during @entity2710 (MCh) bronchoprovocation in @entity28 (OBA) and normal-weight (NWA) individuals with @entity565 of mild to moderate severity. METHODS: High-dose MCh challenge tests to a maximum 50% decrease in FEV(1) were conducted in 51 NWA (BMI, 18.5-24.9 kg/m(2); 29% male) and 45 OBA (BMI, 30.1-51.4 kg/m(2); 33% male) between 20 and 60 years of age. Serial spirometry, inspiratory capacity (IC), plethysmographic end-expiratory lung volume (EELV) and @entity1353 intensity using the Borg scale were measured throughout bronchoprovocation. MEASUREMENTS AND MAIN RESULTS: Spirometry and airway sensitivity were similar in both groups; baseline EELV was lower (P < 0.0005) and IC was higher (P = 0.007) in OBA compared with NWA. From baseline to PC(20), EELV increased more in OBA (20% predicted) than NWA (13% predicted) (P = 0.008) with concomitant greater reductions in IC (P < 0.0005). Dyspnea ratings were not different for a given FEV(1) or IC across groups. By mixed effects regression analysis, relationships between induced @entity1353 and changes in lung function parameters were not influenced by BMI, sex, or their interaction. CONCLUSIONS: Perceptual responses to MCh-induced @entity358 were similar in @entity28 and normal-weight individuals with @entity565 despite significant group differences in baseline lung volumes.
