Comparison patterns of 4 T1 antigens recognized by humoral immune response mediated by IgG and IgM antibodies in female and male XXXX with @entity0 using 2D-immnunoblots.

@entity5 @entity1 @entity19 @entity0
UNASSIGNED: The early detection of @entity5 is one of the most promising approaches to reduce its growing burden and develop a curative treatment before the @entity5 is established. The early diagnosis of @entity0 is the most demanding of all @entity5 , because it is the most common @entity5 in @entity1 worldwide. We have described a new approach to analyze humoral immune reactions against 4 T1 cell antigens in female @entity19 , reporting that the IgG and IgM responses differed and varied over time and between individuals. In this study, we compared and analyzed the detection of @entity5 antigens with IgG and IgM from the sera of male @entity19 that were injected with 4 T1 cells into the mammary gland nipple in 2D immunoblot images. The variability in IgM and IgG responses in female and male @entity19 with @entity0 at various stages of disease was characterized, and the properties with regard to antigen recognition were correlated statistically with variables that were associated with the individuals and @entity5 . The ensuing IgG and IgM responses differed. Only the IgG response decreased over time in female @entity19 - not in male @entity19 . The IgM response was maintained during @entity5 development in both sexes. Each @entity19 had a specific pattern of antigen recognition - ie, an immunological signature - represented by a unique set of antigen spots that were recognized by IgM or IgG. These data would support that rationale IgM is a better tool for early diagnosis, because it is not subject to immunosuppression like IgG in female @entity19 with @entity0 .
