Effect of Replacing Animal Protein with Plant Protein on Glycemic Control in XXXX : A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

@entity23 @entity413 @entity6
UNASSIGNED: Previous research on the effect of replacing sources of animal protein with plant protein on glycemic control has been inconsistent. We therefore conducted a systematic review and meta-analysis of @entity23 ( @entity23 ) to assess the effect of this replacement on glycemic control in individuals with @entity6 . We searched MEDLINE, EMBASE, and Cochrane databases through 26 August 2015. We included @entity23 >=  3-weeks comparing the effect of replacing animal with plant protein on HbA1c, fasting @entity413 (FG), and fasting insulin (FI). Two independent reviewers extracted relevant data, assessed study quality and risk of bias. Data were pooled by the generic inverse variance method and expressed as mean differences (MD) with 95% confidence intervals (CIs). Heterogeneity was assessed (Cochran Q-statistic) and quantified (I  -statistic). Thirteen @entity23 (n = 280) met the eligibility criteria. Diets emphasizing a replacement of animal with plant protein at a median level of ~35% of total protein per day significantly lowered HbA1c (MD = -0.15%; 95%-CI: -0.26, -0.05%), FG (MD = -0.53 mmol/L; 95%-CI: -0.92, -0.13 mmol/L) and FI (MD = -10.09 pmol/L; 95%-CI: -17.31, -2.86 pmol/L) compared with control arms. Overall, the results indicate that replacing sources of animal with plant protein leads to modest improvements in glycemic control in individuals with @entity6 . Owing to uncertainties in our analyses there is a need for larger, longer, higher quality trials. TRIAL REGISTRATION: ClinicalTrials.gov registration number: NCT02037321.
