@entity37159 is a biomarker for XXXX prognosis and @entity9190 inhibitor therapy.

@entity1 @entity0 @entity12061 @entity5 @entity3003 @entity37159 @entity46804 @entity9190
Members of the heterochromatin protein 1 family ( @entity12061 , b and y) are mostly associated with heterochromatin and play important roles in gene regulation and DNA damage response. Altered expression of individual @entity12061 subtype has profound impacts on cell proliferation and tumorigenesis. We analyzed the expression profile of @entity12061 family by data mining using a published microarray data set coupled with retrospective immunohistochemistry analyses of archived @entity0 biospecimens. We found that the @entity1 group overexpressing @entity37159 mRNA is associated with poorly differentiated @entity0 and with a significantly lower survival rate. Immunohistochemical staining against @entity12061 , @entity37159 and HP1y shows that respective @entity12061 expression level is frequently altered in @entity0 . 57.4-60.1% of samples examined showed high @entity37159 expression and 39.9-42.6 % of examined @entity5 showed no or low expression of each @entity12061 subtype. Interestingly, comparative analysis on @entity12061 expression profile and @entity0 markers revealed a positive correlation between the respective expression level of all three @entity12061 subtypes and Ki-67, a cell proliferation and well-known @entity0 marker. To explore the effect of individual @entity12061 on @entity9190 inhibitor therapy for @entity0 , MCF7 @entity0 cells and individually @entity12061 -depleted MCF7 cells were treated with @entity9190 inhibitor @entity46804 with or without @entity3003 . Notably, @entity37159 -knockdown cells are hypersensitive to the @entity9190 inhibitor @entity46804 alone and its combination with @entity3003 . In summary, while increased @entity37159 expression is associated with the poor prognosis in @entity0 , compromised @entity37159 abundance may serve as a useful predictive marker for chemotherapy, including @entity9190 inhibitors against @entity0 .
