Utility of haematological parameters and @entity1851 in the detection of XXXX .

@entity281 @entity295 @entity262 @entity1851
OBJECTIVE: To evaluate various haematological parameters, individually and in combination, to formulate a @entity262 ( @entity262 , defined by Rodwell et al.), which can then be used to screen for @entity295 in neonates who are clinically suspected of @entity281 .1 METHODS: The study cohort consisted of 150 neonates (from birth to 3 days old) with clinically suspected @entity281 . Blood was collected by peripheral venepuncture in all neonates. A complete blood count, differential leucocyte count, total leucocyte count (TLC), total neutrophil count (TNC), immature neutrophil count, band form count and platelet count were performed. Immature total neutrophil count (I/T) and immature/mature neutrophil count (I/M) ratios were then obtained. @entity1851 ( @entity1851 ) was measured semiquantitatively and blood culture and antibiotic sensitivity were performed in each case. The haematological parameters were compared individually and in combination (by @entity262 ) with @entity1851 . RESULTS: Twenty-one (14%) neonates had blood culture proven @entity295 . On evaluation of various haematological parameters, TLC < 10 x 109/L, TNC < 8 x 109/L, I/M > 0.25, I/T > 0.14, band count > 15% and platelet count < 150 x 109 were found to have optimal sensitivities and negative predictive values (NPV). Using these values, an @entity262 was formulated. A haematological score > or = 3 had a sensitivity of 86% and NPV of 96%. @entity1851 as a single test had a sensitivity of 76% and NPV of 96%. A combination of @entity1851 with haematological parameters decreased the sensitivity and NPV of the @entity262 . CONCLUSIONS: A haematological score can be obtained by a complete blood count and examination of peripheral blood smear, thus permitting an objective assessment of haematological changes that occur in a neonate suspected of @entity295 . @entity1851 does not have any advantage over @entity262 , either as a single test or in combination.
