Role of the @entity5 necrosis factor family member LIGHT in the pathogenesis of XXXX .

@entity1 @entity483 @entity5 @entity102 @entity20363
BACKGROUND: LIGHT (the name of which is derived from "homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus @entity20363 for herpes simplex virus entry mediator, and expressed by T lymphocytes"), is a member of the @entity5 necrosis factor superfamily that is involved in various inflammatory diseases. OBJECTIVES: To assess serum LIGHT levels in @entity1 with @entity483 ( @entity483 ) before and after treatment and compare it with controls. To correlate serum LIGHT with the severity scoring of @entity483 (SCORAD) index. Another objective is to compare LIGHT levels between lesional skin in @entity1 with @entity483 and controls. METHODS: Twenty @entity1 with @entity483 and 20 healthy controls were enrolled in the study. Serum LIGHT levels were examined using an enzyme immunoassay technique. Serum total IgE levels, absolute eosinophil count, and eosinophil percentage were also done for both @entity1 and controls. The SCORAD index was done for every @entity1 before and after treatment. Skin LIGHT levels were analyzed using enzyme-linked immunosorbent assay kit and compared with control skin. RESULTS: Serum LIGHT levels in @entity1 with @entity483 were significantly higher than that of healthy controls and correlated positively with SCORAD index. LIGHT concentrations decreased as the symptoms were improved by treatment. A significant correlation was found on comparing the LIGHT serum levels and other established markers of disease severity. LIGHT levels in lesional skin in these @entity1 were markedly higher than LIGHT levels in normal skin. CONCLUSION: LIGHT may play an important role in the pathogenesis of @entity483 . This may presumably have possible future implications on the treatment of this @entity102 .
