Effect of @entity2494 ( @entity2494 ) on intestinal mucosal immunity in young adult and aging XXXX .

@entity35 @entity2494 @entity3081
The present study assesses the effectiveness of oral @entity2494 on the intestinal mucosal immune response in aging @entity35 . Young adult (6 months) and aging (21 months) female @entity35 received powdered @entity35 chow with or without 0.2% @entity2494 for 23 days. The animals were immunized intraduodenally with either @entity3081 ( @entity3081 ) or vehicle alone and boosted two weeks later. Seven days after boosting, serum, bile, small intestinal tissue, and liver were collected for analysis. Anti- @entity3081 IgA antibody titers were measured in serum and bile and the concentration of anti- @entity3081 antibody containing cells (ACCs) in the small intestinal lamina propria and liver were determined by quantitative immunohistochemistry. Intergroup comparisons indicated that there was only one significant difference in serum and none in bile anti- @entity3081 IgA titers between @entity3081 -immunized animals fed @entity2494 or the diet alone. Immunohistochemical analysis determined that the density and distribution patterns of ACCs within the lamina propria were unaffected by @entity2494 . Both @entity2494 -treated and control young immunized animals exhibited similar numbers of ACCs. Only 40% of the aging @entity35 responded to intraduodenal immunization with @entity3081 , as determined by the presence of ACCs in the intestine, regardless of the presence or absence of @entity2494 in the diet. These data suggest that @entity2494 in the diet does not enhance the intestinal mucosal immune response to intraduodenal @entity3081 in either young adult or aging @entity35 .
