Association of GWAS-based candidate genes with HDL- @entity165 levels before and after bariatric surgery in the Swedish XXXX subjects study.

@entity25024 @entity72666 @entity28 @entity72665 @entity5705 @entity17764 @entity36548 @entity5112 @entity72667 @entity21123 @entity72664 @entity5523 @entity28371 @entity23353 @entity165
CONTEXT AND OBJECTIVE: The magnitude of weight loss-induced high-density lipoprotein @entity165 (HDL-C) changes may depend on genetic factors. We examined the associations of eight candidate genes, identified by genome-wide association studies, with HDL-C at baseline and 10 yr after bariatric surgery in the Swedish Obese Subjects study. METHODS: Single-nucleotide polymorphisms (SNP) (n = 60) in the following gene loci were genotyped: @entity21123 , @entity23353 , @entity28371 , @entity36548 , @entity5705 , @entity25024 , @entity5523 , and @entity5112 / @entity17764 . Cross-sectional associations were tested before (n = 1771) and 2 yr (n = 1583) and 10 yr (n = 1196) after surgery. Changes in HDL-C were tested between baseline and yr 2 (n = 1518) and yr 2 and 10 (n = 1149). A multiple testing corrected threshold of P = 0.00125 was used for statistical significance. RESULTS: In adjusted multivariate models, @entity28371 SNP @entity72664 explained from 3.2-4.2% (P < 10(-14)) of the variation in HDL-C at all three time points, whereas @entity28371 SNP @entity72665 contributed an additional 0.6 and 0.9% at baseline and yr 2, respectively. @entity5705 SNP @entity72666 showed consistent associations across all time points (R(2) = 0.4-1.1%; 3.8   10(-6) < P < 3   10(-3)), whereas @entity5523 SNP @entity72667 contributed approximately 0.5% (5   10(-4) < P < 0.0012) at yr 2 and 10. In aggregate, four SNP in three genes explained 4.2, 6.8, and 5.6% of the HDL-C variance at baseline, yr 2, and yr 10, respectively. None of the SNP was significantly associated with weight loss-related changes in HDL-C. CONCLUSIONS: SNP in the @entity28371 , @entity5705 , and @entity5523 loci contribute significantly to plasma HDL-C levels in @entity28 individuals, and the associations persist even after considerable weight loss due to bariatric surgery. However, they are not associated with surgery-induced changes in HDL-C levels.
