Kidney function during common carotid artery occlusion in anaesthetized XXXX : influence of vagotomy, constant ventilation, blood pressure stabilization, and carotid body chemoreceptor inactivation.

@entity2011 @entity235 @entity26 @entity1372 @entity432 @entity468
The reactions of kidney function elicited by bilateral common carotid artery occlusion were studied in six groups of chloralosed @entity468 in which the Nn. vagi, the breathing reaction, the increase of the mean systemic arterial blood pressure, and the carotid body chemoreceptors were excluded successively. @entity432 in the control animals caused a rise of the mean systemic arterial blood pressure, hyperventilation, and an increase in renal @entity1372 and water excretion, resulting from an inhibition of tubular reabsorption. Bilateral cervical vagotomy, relaxation and constant artificial ventilation only slightly modified this renal response. Inactivation of the carotid body chemoreceptors in vagotomized and constantly ventilated @entity468 attenuated the natriuresis due to @entity432 regardless of the behaviour of the renal perfusion pressure. On the other hand, keeping the mean arterial blood pressure during @entity432 constant by the bleeding technique also reduced the natriuretic reaction. @entity468 with both inactivated carotid body chemoreceptors and constant renal perfusion pressure exhibited an antinatriuretic reaction during carotid clamping. From these data it is concluded that in narcotized @entity468 the natriuretic response during @entity432 is the result of both a stimulation of the carotid body chemoreceptors and the rise of the renal perfusion pressure. In contrast, in @entity235 this so-called carotid-sinus- @entity2011 seems to be induced solely by the increase of the systemic arterial blood pressure. The findings additionally indicated that the arterial chemoreceptors may be involved in the physiological daily control of renal @entity1372 excretion already at normal arterial @entity26 tension under sea-level conditions.
