Salvage abdominoperineal resection in XXXX .

@entity1 @entity66 @entity5 @entity245 @entity281
BACKGROUND: In the management of isolated locoregional failure after (chemo)radiation therapy for @entity5 , salvage abdominoperineal resection (APR) is the treatment of choice. The results of a 15-year consecutive population-based series are reviewed. METHODS: Details of all @entity1 with @entity5 treated from 1985 to 2000 in the Stockholm Health Care Region were recorded prospectively. Among 308 @entity1 with biopsy-proven @entity5 , there have been 39 isolated locoregional failures after sphincter-preserving therapy. Thirty-five @entity1 have undergone salvage APR. The medical records of these 35 @entity1 were reviewed retrospectively with regard to surgical and oncological results. RESULTS: There were no postoperative deaths. There was considerable morbidity related to the perineal wound, with postoperative perineal @entity281 in 13 @entity1 and @entity245 beyond 3 months in 23 @entity1 . Complications unrelated to the perineal wound were found in 13 @entity1 . The crude 5-year survival rate for the 35 @entity1 was 52 per cent (median follow-up 33 months). @entity1 with @entity66 fared significantly worse than those with locoregional recurrence (crude 5-year survival rate 33 versus 82 per cent; P < 0.05, log rank test). CONCLUSION: Salvage APR in @entity5 is associated with a high complication rate but may result in long-term survival.
