Utility of serum lipid ratios for predicting XXXX : the Isfahan Diabetes Prevention Study.

@entity2175 @entity1 @entity9680 @entity412 @entity413 @entity165
BACKGROUND: In this study we evaluate the association between @entity412 to high-density lipoprotein @entity165 (TG/ @entity9680 ) ratio and total @entity165 (TC) to @entity9680 ( @entity9680 ) ratio and the risks of @entity2175 ( @entity2175 ) in an Iranian high-risk population. METHODS: We analysed 7-year follow-up data (n   =   1,771) in non-diabetic first-degree relatives of consecutive @entity1 with @entity2175 30-70 years old. The primary outcome was the diagnosis of @entity2175 based on repeated oral @entity413 tolerance tests. We used Cox proportional hazard models to estimate hazard ratio (HR) for incident @entity2175 across tertiles of TG/ @entity9680 and @entity9680 ratios and plotted a receiver operating characteristic (ROC) curve to assess discrimination. RESULTS: The highest tertile of TG/ @entity9680 and @entity9680 ratios compared with the lowest tertile was not associated with @entity2175 in age and gender adjusted models (HR 0.99, 95% CI: 0.88, 1.11 for TG/ @entity9680 ratio and 1.10, 95% CI: 0.97, 1.23 for @entity9680 ratio). Further adjustment for waist circumference or body mass index, fasting plasma @entity413 , and low-density lipoprotein @entity165 did not appreciably alter the HR compared to the age- and gender-adjusted model. The area under the ROC curve for TG/ @entity9680 ratio was 57.7% (95% CI: 54.0, 61.5) and for @entity9680 ratio was 55.1% (95% CI: 51.2, 59.0). CONCLUSIONS: TG/ @entity9680 and @entity9680 ratios were not robust predictors of @entity2175 in high-risk individuals in Iran. This article is protected by copyright. All rights reserved.
