Antitumor effects of two polyamine antimetabolites combined with @entity1138 on @entity1 XXXX cells xenotransplanted into @entity19 .

@entity1 @entity5 @entity19 @entity1138 @entity8037 @entity7224 @entity2665 @entity1139 @entity11747 @entity11667
The antitumor effects of @entity11747 ( @entity11747 ), @entity2665 ( @entity2665 ) and @entity1138 ( @entity1139 ), administered separately or in various combinations, on @entity1 @entity5 cells xenotransplanted into BALB/c @entity19 were studied using the protocol of Battelle's Columbus Laboratories (Ovejera et al., 1978). @entity11747 (1,000 mg/kg in 2 divided doses) and @entity2665 (50 mg/kg) were given intraperitoneally (i.p.) for 7 consecutive days from the time when the @entity5 weighed about 100 mg. @entity1139 (2 mg/kg) was given i.p. every other day from the same time. Animals treated with either @entity11747 or @entity2665 alone displayed @entity5 growth comparable to that seen in untreated controls. In @entity19 treated with @entity11747 plus @entity2665 with or without @entity1139 , or in @entity19 treated only with @entity1139 , @entity5 growth was significantly lower than in untreated @entity19 . In the group which received only combined @entity11747 / @entity2665 there was a rapid regrowth of the @entity5 after termination of therapy. @entity5 putrescine levels decreased within 4 days following the administration of @entity11747 ; however, @entity11667 levels did not decline with either @entity11747 or @entity2665 treatment even after 7 days. When combined @entity11747 / @entity2665 was given, there was a significant decline in @entity11667 levels 7 days after the initiation of treatment. In contrast, when @entity1139 alone was administered, @entity7224 and @entity11667 levels in the @entity5 did not differ from those in control @entity19 . @entity8037 decreased markedly in @entity5 with the combined administration of @entity11747 / @entity2665 as well as with combined @entity11747 / @entity2665 / @entity1139 , but decreased only slightly when @entity1139 alone or @entity1139 plus either @entity11747 or @entity2665 was administered. By the 7th treatment day, DNA biosynthesis in the @entity5 had dropped markedly in all groups except those receiving @entity11747 or @entity2665 alone.
