XXXX : benign polypoid masses following radiation therapy.

@entity1 @entity1697 @entity242 @entity5 @entity6437 @entity189 @entity1544 @entity2277
BACKGROUND: The current study evaluated postirradiation @entity6437 in the oral cavity to investigate clinical and pathologic characteristics and incidence rates. METHODS: Between 1960 and 1999, 2719 @entity1 with @entity1544 were treated with radiation therapy at Tokyo Medical and Dental University Hospital. Of these, six @entity1 developed clinically polypoid @entity5 pathologically diagnosed as @entity6437 . Histopathology, immunohistology, and the clinical courses of these lesions were investigated. RESULTS: Spindled fibroblastic cells arranged in whorled patterns were common pathologic features. Immunohistochemical results showed reactivity for @entity2277 and smooth muscle actin and nonreactivity for cytokeratin. The latent period from the initial radiation therapy to the development of the @entity6437 ranged from 45 to 145 months (median, 79 months). The overall cumulative incidence of @entity6437 was 0.22% during the 40 year period. All six @entity1 were cured with simple excisions. CONCLUSIONS: @entity1697 @entity1 treated with radiation therapy may develop @entity6437 in a low frequency with a shorter period than that of radiation induced @entity189 / @entity242 . @entity6437 was curable with surgery. @entity6437 should be added to the list of differential diagnosis for postirradiation oral polypoid masses.
