XXXX screening with low-dose computed tomography: Experiences from a tertiary hospital in Taiwan.

@entity1 @entity2735 @entity5 @entity2 @entity420
BACKGROUND/PURPOSE: @entity2 screening using low-dose computed tomography (CT) has been reported to reduce @entity2 -specific mortality for smokers at high risk. However, despite different characteristics of @entity2 in Asia, there are few data concerning this specific population for screening. We aim to analyze the performance of @entity2 screening with low-dose CT concurrent with chest radiography in Taiwan, with reference to international experience. METHODS: During the 1-year period from January 2012 to December 2012, we conducted a retrospective, single-center population-based screening program for @entity2 in the setting of annual medical examinations. @entity1 were asymptomatic adults without prior history of any @entity5 . Low-dose CT and chest radiography were offered to all individuals. Baseline CT evaluations were defined as positive if any noncalcified nodule>= 4  mm in diameter, which were then classified as solid, pure ground-glass or partial ground-glass opacity. RESULTS: Of 3339 individuals, we detected 34 @entity5 , yielding an overall @entity5 detection rate of 1.02%. There was a particularly high @entity5 detection rate of 6.2% (8/129) in the high-risk group aged younger than 50  years with a positive family history of all types of @entity5 in first-degree relatives. @entity420 accounted for 88% (30/34) of @entity5 and 99% of them were early-stage (including @entity2735 and Stage I). The probability of @entity5 was significant higher in nodules with interval growth (odds ratio 257.89, p  =  0.0002). There was no significant difference in the probability of @entity5 between ground glass opacity nodules and solid nodules (odds ratio 1.16, p=0.72). Of all screen-detected @entity5 , 61.76% (21/34) were chest radiographically occult. CONCLUSION: Low-dose CT is effective to detect early @entity2 . Further establishment of selection criteria for @entity2 screening, specifically for Asian individuals, is definitely warranted.
