Levodopa and XXXX in hypoxic brain injury.

@entity1 @entity18776 @entity12807 @entity2847 @entity1688 @entity2003 @entity75 @entity2358 @entity2730 @entity2845 @entity1957 @entity519 @entity497 @entity2146 @entity1576 @entity74 @entity1167 @entity1282 @entity6564 @entity2414
BACKGROUND: Postanoxic @entity75 is frequent in @entity1 presenting with abrupt @entity1167 or @entity1576 . Little is known about the effectiveness of oral medications on the cognitive and motor consequences. OBJECTIVE: To present data suggesting partial improvement after administration of levodopa/ @entity18776 . METHODS: After observing partial benefit in one case, each @entity1 admitted to rehabilitation following @entity12807 was systematically treated with levodopa/ @entity18776 (200/50 to 400/100 mg/day), then @entity2847 (15 mg/day). RESULTS: In the first @entity1 , @entity12807 was severe, with secondary @entity2146 , @entity1688 , @entity2358 , @entity497 . Introduction of levodopa/ @entity18776 resulted in @entity2146 and @entity2358 and improvement of communication, thus facilitating care and rehabilitation efforts. A weaning test resulted in rapid worsening. The four following @entity1 also presented with @entity519 of variable severity. Marked improvement was observed in case 2, presenting with @entity2146 , loss of orientation, @entity2730 , @entity74 , @entity2358 and @entity1282 , with a withdrawal test resulting in immediate re-enhancement of symptoms. Modest improvement was observed in @entity1 3, who had @entity2845 , @entity2003 , @entity6564 , impaired attention, and reduced verbal fluency. @entity1 4 presented with @entity2414 without motor difficulties: mild improvement was observed in daily life and memory tests. In @entity1 5 who also presented with severe @entity2414 , the benefit was absent. In each case, @entity2847 was introduced 3-4 weeks following levodopa, but without additive effect. Both treatments could be interrupted after a few months, without worsening. CONCLUSIONS: Levodopa and @entity18776 can be of benefit in the few months following @entity12807 , especially on some of the @entity1957 and apathy, but the benefit is inconstant and modest on @entity2414 . @entity519 could alter dopaminergic mesencephalic systems, which activate the striatal and mediobasal frontal cortex, and these disorders could be partially reversible by medical treatment.
