XXXX and @entity2857 : Diagnosis, indications, clinical and radiological follow-up.

@entity5 @entity157 @entity1 @entity2857
@entity5 ( @entity157 ) is a category of disease defined by radiological, clinical and hepatic function parameters, comprehending a wide range of @entity1 with different general conditions. The main therapeutic option is represented by @entity2857 treatment, a multi-kinase inhibitor with anti-proliferative and anti-angiogenic effect. Trans-arterial Radio Embolization also represents a promising new approach to intermediate/advanced @entity157 . Post-marketing clinical studies showed that only a portion of @entity1 actually benefits from @entity2857 treatment, and an even smaller percentage of @entity1 treated shows partial/complete response on follow-up examinations, up against relevant costs and an incidence of drug related adverse effects. Although the treatment with @entity2857 has shown a significant increase in mean overall survival in different studies, only a part of @entity1 actually shows real benefits, while the incidence of drug related significant adverse effects and the economic costs are relatively high. Moreover, only a small percentage of @entity1 also shows a response in terms of lesion dimensions reduction. Being able to properly differentiate @entity1 who are responding to the therapy from non-responders as early as possible is then still difficult and could be a pivotal challenge for the future; in fact it could spare several @entity1 a therapy often difficult to bear, directing them to other second line treatments (many of which are at the moment still under investigation). For this reason, some supplemental criteria to be added to the standard modified Response Evaluation Criteria in Solid Tumors evaluation are being searched for. In particular, finding some parameters (cellular density, perfusion grade and enhancement rate) able to predict the sensitivity of the lesions to anti-angiogenic agents could help in stratifying @entity1 in terms of treatment responsiveness before the beginning of the therapy itself, or in the first weeks of @entity2857 treatment. This would bring a strongly desirable help in clinical managements of these @entity1 .
