Inverse expressions of the XXXX oncogene and @entity2393 in @entity1 @entity521 : relationships to disease progression in a nude @entity19 model system.

@entity1 @entity146 @entity19 @entity5 @entity521 @entity2393 @entity4180
A nude @entity19 model for @entity1 @entity521 has been developed to examine possible relationships between amplification/over-expression of the @entity4180 oncogene and altered regulation of expression of specific integrin subunits during @entity5 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity521 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity5 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity4180 ) or IMR-32 cells (which over-express @entity4180 ) produce @entity5 at higher rates when re-injected into the subcutaneous space of @entity19 . Moreover, cell lines derived from @entity5 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity2393 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity1 cells, which express @entity4180 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity5 -derived cell lines (especially those from @entity5 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity5 take rate observed when the cells are re-injected into @entity19 . Our results raise the possibility of a relationship between over-expression of @entity4180 and down-regulation of @entity2393 expression (possibly some alpha subunits also). In addition, the data suggest that @entity1 @entity521 -derived cell lines which exhibit reduced integrin expression display more @entity146 growth in @entity19 .
