Toxicity of XXXX . I. Hematotoxicity following subacute exposure in @entity35 .

@entity73276 @entity1373 @entity381 @entity5714 @entity382 @entity35 @entity435
@entity73276 ( @entity435 ) was given po to male and female Fischer 344 @entity35 at dose levels of 10, 25, 75, 150, and 300 mg/kg, five times a week for a period of 2 weeks. Control animals received distilled water. All animals given intermediate dose levels (10, 25, 75, and 150 mg/kg) and one half of the animals which were dosed at the high dose (300 mg/kg) as well as one half of the controls were terminated 14 days after administration of the first dose. The remaining @entity35 received no treatment for an additional 14 days and were sacrificed on Day 28 of the study (recovery phase). Dose-related decreases in erythrocyte number, hemoglobin, and hematocrit, with an accompanying increase in reticulocytes and circulating nucleated erythrocytes, were observed in both sexes at Day 14. Methemoglobin levels, determined only at the high dose, were elevated in both sexes at this time. @entity381 and @entity382 were observed in both sexes at 14 and 28 days. Histopathological examination of the spleen and bone marrow revealed dose-related @entity1373 at 14 days which subsided by Day 28. The above effects were more pronounced in males. Erythrocyte numbers were only slightly depressed and reticulocytes mildly elevated in males at Day 28. Hematological values were not statistically different from controls in females at this time. These results suggest that @entity435 induces oxidative damage to the erythrocyte, resulting in a @entity5714 accompanied by increased erythropoiesis. The toxic effects appear reversible upon cessation of exposure.
