Cytokeratin-positive subserosal myofibroblasts in XXXX ; another type of myofibroblasts.

@entity1 @entity10189 @entity3986 @entity1066 @entity5932 @entity1970 @entity2279 @entity2914 @entity2280
To investigate the distribution and origin of @entity1970 ( @entity1970 )-positive stromal cells in the perforation of @entity1 @entity10189 . Perforative lesions of 24 surgically resected @entity10189 were examined immunohistochemically for @entity1970 , @entity2914 , @entity2280 , @entity2279 , CAM5.2 and HMW-CK, and double staining of @entity1970 and CAM5.2 was also performed. In addition, to determine the cell source of collagen, in situ hybridization of collagen I mRNA was performed. In the normal gastroduodenal wall, the reticular network of @entity2280 -positive stromal cells was identified in the @entity5932 , @entity3986 , and subserosa. In the subepithelial area, many myofibroblasts were observed, whereas no @entity2280 -positive stromal cells were seen. In areas neighboring ulcerative lesions, no @entity2280 -positive stromal cells were observed, but a significant number of myofibroblasts were present there. In the deep layer of @entity1066 , numerous fusiform or stellate stromal cells strongly positive for @entity1970 and CAM5.2 were observed in the subserosal area around the perforation. In the same site, many cells co-expressing @entity1970 and CAM5.2 were identified by double staining. In contrast, in the surface layer of @entity1066 , stromal cells expressing only @entity1970 were observed. The cytokeratin-positive subserosal myofibroblastic cell in @entity1 @entity10189 is a novel type of myofibroblast.
