Mycosis fungoides: management with topical XXXX mustard.

@entity1 @entity4888 @entity1568 @entity5 @entity56 @entity74 @entity72598 @entity204
The technique of treatment, response rate, freedom from relapse, survival, and complications of therapy in 123 @entity1 treated with topical @entity1568 mustard ( @entity72598 ) for @entity4888 ( @entity4888 ) at Stanford University Medical Center are reviewed. @entity1 were treated with @entity72598 in an aqueous or ointment base with equal efficacy. Response rates depended on the extent of skin involvement. In limited plaque (T1) disease, complete and overall response rates were 51% and 88%, respectively, while in generalized plaque (T2) disease they were 26% and 69%. No @entity1 with @entity5 involvement (T3) achieved complete skin clearance and all 13 of these @entity1 developed @entity74 . Only two of nine @entity1 with erythrodema (T4) achieved a complete response (CR), and both later relapsed. After achieving a CR, 40% of @entity1 with T1 disease and 60% with T2 disease later relapsed; however, subsequent therapies, including repeat courses of topical @entity72598 , often were successful in achieving later skin clearance. Overall, 42% of T1 @entity1 and 31% of T2 @entity1 were without evidence of @entity4888 at last follow-up. When @entity204 occurred, it was usually unrelated to @entity4888 in the T1 group. However, half of the @entity204 of @entity1 with T2 disease were attributable to @entity4888 . Among the 22 @entity1 with T3 or T4 disease, 80% of @entity204 were attributable to @entity4888 . The most common complication observed was a cutaneous @entity56 , which occurred much more commonly with the aqueous than the ointment preparation. Fourteen @entity1 (11%) developed subsequent cutaneous @entity5 .
