XXXX : Correlation between Molecular Profiling and Imaging Phenotypes.

@entity1 @entity7738 @entity7 @entity5 @entity470 @entity7465 @entity11707 @entity2030 @entity876 @entity13456 @entity519 @entity201 @entity1419 @entity1365
PURPOSE: To investigate associations between imaging features of @entity201 by visual assessment and texture analysis, which quantifies heterogeneity in @entity5 enhancement patterns, with molecular profiles based on @entity519 markers. METHODS: The institutional review board approved this HIPAA-compliant retrospective study of CT images of @entity1419 , obtained before surgery. Immunostaining for @entity519 markers ( @entity470 , @entity7 , @entity11707 , @entity876 , @entity7465 , @entity13456 , @entity7738 , @entity2030 , and @entity1365 ) was performed on pre-treatment liver biopsies. Quantitative imaging phenotypes were determined by texture analysis with gray level co-occurrence matrixes. The correlations between quantitative imaging phenotypes, qualitative imaging features (measured by radiographic inspection alone), and expression levels of the @entity519 markers from the 25 @entity5 were assessed. RESULTS: Twenty-five @entity1 were included with a median age of 62 years (range: 54-84). The median @entity5 size was 10.2 cm (range: 4-14), 10 (40%) were @entity5 , and 90% were moderately differentiated. Positive immunostaining was recorded for @entity7 in 67% of the cases, @entity470 in 75%, and @entity11707 in 55%. On multiple linear regression analysis, quantitative imaging phenotypes correlated significantly with @entity470 and @entity7 expression levels (R2 = 0.4, p<0.05 and R2 = 0.2, p<0.05, respectively), while a trend was demonstrated with @entity11707 expression (R2 = 0.33, p = 0.1). Three qualitative imaging features correlated with @entity7 and @entity11707 expression (P<0.05), however, none of the qualitative features correlated with the quantitative imaging phenotypes. CONCLUSION: Quantitative imaging phenotypes, as defined by texture analysis, correlated with expression of specific markers of @entity519 , regardless of conventional imaging features.
