The association between urinary XXXX excretion and cardiovascular risk factors, bone status and quality of life in the population.

@entity1 @entity701 @entity209
OBJECTIVE: @entity1 with glucocorticoid excess have increased cardiovascular risk, decreased bone mineral density and impaired quality of life (QoL). The aim of this study was to evaluate the association between urinary @entity701 excretion and cardiovascular risk factors, bone status and QoL in the population. We hypothesized that higher @entity701 excretion was associated with adverse cardiovascular risk profile, worse skeletal health and QoL. DESIGN, @entity1 AND METHODS: This was a cross-sectional study including a population sample (n=348), aged 38-77years. The mean age in @entity1 was 64.0  8.5years (n=276) and 60.3  10.2years in @entity1 (n=72). The @entity209 , body composition measured with bioimpedance, calcaneal quantitative ultrasound, fractures and QoL evaluated with the Nottingham Health Profile, Psychological General Well-Being (PGWB) and the Short Form 36 (SF-36) were studied. Urinary free @entity701 (UFC) was measured using radioimmunoassay. RESULTS: UFC was higher in @entity1 (230  120nmol/L) compared to @entity1 (153  71; P<0.001) and decreased with increasing age (P<0.001). In a regression analysis, after adjustment for gender, age and body mass index, higher UFC was associated with higher fat-free mass (P<0.01), favourable calcaneal bone measurements (P<0.05), better general health measured with PGWB (P<0.01) and SF-36 (P=0.001) and tended to be negatively associated with the @entity209 (P=0.07). CONCLUSION: In contrast to our hypothesis, UFC in the upper physiological range was associated with a favourable cardiovascular risk profile, bone measures and QoL.
