Implementation of assisted reproductive technologies following conservative management of FIGO grade I XXXX with atypia.

@entity1 @entity1204 @entity1373 @entity7828 @entity1869 @entity420
OBJECTIVE: The objective was to report a series of infertility therapy outcomes following conservative management of @entity1869 with atypia. METHODS: A retrospective review of the University of Iowa assisted reproductive technology database was performed. All @entity1 presenting with International Federation of Obstetrics and Gynecology (FIGO) grade I uterine @entity420 with atypia were assessed for type and duration of medical management, initial, interim treatment, and preinfertility treatment endometrial biopsy (BX) findings. Assessment of infertility treatment outcomes and postinfertility endometrial biopsy findings were performed. All of the pathology samples were re-reviewed at the Gynecologic Oncology Tumor Board to confirm the diagnosis by a pathologist with a particular expertise in gynecologic pathology. RESULTS: Four infertile @entity1 , three nulligravid and one primigravid, were evaluated with the diagnosis of FIGO grade 1 @entity1869 with atypia desiring to preserve fertility. Two @entity1 with FIGO grade 1 @entity1204 were successfully treated with high-dose progestational agents resulting in normal proliferative endometrium. In addition, both @entity1 with @entity1373 with atypia were successfully treated with @entity7828 and/or ovulation induction. Successful pregnancy outcomes were achieved for three of the four @entity1 with assisted reproductive technology. A total of five successful pregnancies and eight healthy live-born @entity1 were achieved among three @entity1 . One of the four @entity1 was unable to conceive despite three cycles of in vitro fertilization. Hysterectomy was performed for recurrent @entity1373 with atypia. In our series, we found it can take 3-10 months (mean, 6.25 months; median, 6 months) to obtain benign endometrium preceding infertility therapy. CONCLUSION: This report demonstrates that conservative management of well-differentiated @entity1869 with atypia followed by aggressive assisted reproduction is an option to highly motivated and carefully selected @entity1 .
