No hypofrontality, but absence of prefrontal lateralization comparing @entity2414 in XXXX .

@entity1 @entity75 @entity409 @entity161 @entity2414
Hypofrontality and decreased lateralization have been two major, albeit controversial, results from functional neuroimaging studies of @entity161 . We used fMRI to study cortical activation during a @entity2414 (WM) task (2-back) in 15 inpatients acutely ill with @entity161 and 15 matched control subjects. We hypothesized (i) hypofrontality in @entity1 in both tasks and (ii) decreased lateralization of prefrontal activation in @entity1 under the assumption that, in controls, left prefrontal cortex (PFC) is engaged preferentially in the verbal task (verbal domain dominance) and the right prefrontal cortex is engaged preferentially in the spatial task (spatial domain dominance). Our results showed no significant differences in frontal activation between controls and @entity1 , i.e. no hypofrontality in @entity1 , even at a very liberal threshold (p<0.01). This may be explained by the fact that nearly all @entity1 studied received atypical neuroleptics. Nonetheless, we found evidence for more subtle, domain-related @entity409 . Whereas controls showed verbal WM domain dominance in @entity75 and spatial WM domain dominance in right prefrontal cortex, these domain dominance effects were absent in the @entity1 group, i.e. there were no lateralization effects. Finally, only @entity1 showed an inverse correlation between performance and right prefrontal activation in verbal WM. We conclude that the finding of hypofrontality may depend on the medication of the @entity1 and that there is @entity409 even in the absence of hypofrontality.
