Candidate HLA genes for prediction of XXXX -induced severe cutaneous reactions.

@entity1 @entity137 @entity6715 @entity10592 @entity799 @entity11682 @entity1530 @entity18698 @entity1533
BACKGROUND: @entity799 is a @entity11682 -containing antibiotic that is effective in the treatment of several infections and for prophylaxis of @entity10592 . This drug has been reported as a common culprit drug for the @entity6715 ( @entity6715 ) and for @entity137 ( @entity137 ). Human leukocyte antigens (HLAs) play a key role in the immunopathogenesis of severe cutaneous reactions induced by several drugs. This study investigated the association between the HLA class I and @entity1533 polymorphisms and @entity799 -induced @entity6715 / @entity137 in a Thai population. METHODS: Forty-three @entity1 with @entity799 -induced @entity6715 / @entity137 and 91 @entity799 -tolerant @entity1 were enrolled in the study. HLA class I and @entity1533 were genotyped using the reverse sequence-specific oligonucleotide probe method. RESULTS: The frequencies of three alleles of HLA, namely @entity1530 *15:02, @entity18698 *06:02, and @entity18698 *08:01, were significantly higher in the @entity799 -induced @entity6715 / @entity137 group compared with controls. The risks for @entity799 -induced @entity6715 / @entity137 in @entity1 with the @entity1530 *15:02, @entity18698 *06:02, or @entity18698 *08:01 allele were about 3-11-fold higher when compared with those who did not carry one of these alleles. Individuals who carried the @entity1530 *15:02-C*08:01 haplotype had a 14-fold higher risk for @entity799 -induced @entity6715 / @entity137 . CONCLUSION: Evidence of associations between @entity799 -induced @entity6715 / @entity137 and HLA alleles including @entity1530 *15:02, @entity18698 *06:02, and @entity18698 *08:01 were found in the study population. These findings may suggest that apart from the HLA molecules, other molecules involved in the molecular pathogenesis of these severe cutaneous adverse drug reactions may play an important role in the susceptibility of individuals to @entity6715 / @entity137 caused by @entity799 .
