Dentine XXXX : effect of interactions between metal salts, @entity1388 and @entity1216 on the uptake by dentine.

@entity1216 @entity11721 @entity219 @entity9756 @entity56 @entity1388
A large number of compounds may be applied to the teeth for preventive or therapeutic purposes, most notably in dentine @entity56 . The uptake of any one compound by tooth substances may clearly be affected by another to produce synergistic, additive or antagonistic effects. This study determined whether uptake interactions occurred between @entity1388 , @entity1216 , @entity9756 , @entity11721 and @entity219 . All compounds, in particular @entity11721 , showed considerable affinity for dentine. @entity1388 reduced the uptake of @entity219 but not @entity11721 , @entity9756 or @entity1216 . @entity1216 increased the uptake of @entity219 , but not @entity11721 , @entity9756 or @entity1388 . @entity219 and @entity11721 decreased @entity1388 uptake but @entity9756 had no such effect. Finally, @entity1216 uptake was increased by @entity219 and @entity11721 but not by @entity1388 or @entity9756 . Based on the theories proposed for the reaction of these various compounds with calcified tissues, explanations for the interactions can be made. The results appear relevant to some reported clinical effects of combinations of these compounds and indicate that such interactions may have advantageous or disadvantageous consequences depending on the basis for treatment.
