A history of early life parental loss or XXXX is associated with successful cognitive-behavioral therapy in @entity308 .

@entity1 @entity308 @entity701 @entity1172 @entity130
BACKGROUND: There is a clinical need for evidence-based psychotherapy response biomarkers in @entity308 ( @entity308 ). Based on previous studies, we hypothesized that lower 24-h urinary @entity701 levels and a history of early life stress/ @entity130 would predict an improved antidepressant response to cognitive-behavioral therapy (CBT). METHODS: 50 currently depressed @entity308 subjects were enrolled. 24-h urine was collected and measured for @entity701 levels by radioimmunoassay (RIA). Subjects were also administered early life stress/ @entity130 measures at baseline: Global Perceived Early-Life Stress (GPELS), The Early Life @entity130 Inventory (ELTI) and Klein Loss Scale (KLS). The efficacy of a twelve-week course of once-weekly CBT was evaluated by the primary outcome measure, the 24-item Hamilton Depression Rating Scale (HDRS24), at baseline and every four weeks, and the Beck Depression Inventory at baseline and weekly thereafter. 42 subjects had at least one complete follow-up visit (>= 4 weeks of CBT), and 30 subjects completed the full 12-week course. RESULTS: Baseline 24-h urinary @entity701 levels did not correlate with CBT's antidepressant response. Higher KLS scores, a measure of early life parental loss or @entity1172 , correlated with delta HDRS24 (rs=-0.39, padjusted=0.05). Complementary general linear model analysis revealed enhanced CBT efficacy in @entity1 with a history of early life parental loss or @entity1172 [F(1,35)=6.65, p=0.01]. LIMITATIONS: Small sample size, Treatment-na  ve population. CONCLUSIONS: Early life parental @entity1172 or loss positively correlated with CBT's antidepressant efficacy in our sample and may warrant further study in larger clinical samples.
