Tissue prolapse and stresses in stented coronary arteries: A computer model for multi-layer XXXX .

@entity131 @entity82 @entity39 @entity256 @entity731 @entity850 @entity65
UNASSIGNED: Among the many factors influencing the effectiveness of @entity65 , tissue prolapse indicates the potential of a stent to cause @entity256 . The deflection of the arterial wall between the struts of the stent and the tissue is known as a prolapse or draping. The prolapse is associated with @entity131 to the vessel wall due to the high stresses generated around the stent when it expands. The current study investigates the impact of @entity850 severity and plaque morphology on prolapse in stented coronary arteries. A finite element method is applied for the stent, plaque, and artery set to quantify the tissue prolapse and the corresponding stresses in stenosed coronary arteries. The variable size of @entity731 is considered. A plaque is modelled as a multi-layered medium with different thicknesses attached to the single layer of an arterial wall. The results reveal that the tissue prolapse is influenced by the degree of @entity850 severity and the thickness of the plaque layers. Stresses are observed to be significantly different between the plaque layers and the arterial wall tissue. Higher stresses are concentrated in @entity82 layer of the plaque (the harder core), while lower stresses are observed in @entity39 core (the softer core) and the arterial wall layer. Moreover, the morphology of the plaque regulates the magnitude and distribution of the stress. The fibrous cap between the @entity39 core and the endothelium constitutes the most influential layer to alter the stresses. In addition, the thickness of the @entity39 core and the @entity850 severity affect the stresses. This study reveals that the morphology of @entity731 needs to be considered a key parameter in designing coronary stents.
