Frequency-dependent neural activity in XXXX .

@entity1 @entity3034 @entity304 @entity191 @entity2845 @entity4365
The brainstem and basal ganglia are important in the pathophysiology of @entity191 ( @entity191 ). Reliable and sensitive detection of neural activity changes in these regions should be helpful in scientific and clinical research on @entity191 . In this study, we used resting state functional MRI and @entity4365 ( @entity4365 ) methods to examine spontaneous neural activity in 109 @entity1 with @entity191 . We examined activity in two frequency bands, slow-4 (between 0.027 and 0.073 Hz) and slow-5 (0.010-0.027 Hz). @entity1 had decreased @entity4365 in the striatum and increased @entity4365 in the midbrain, and changes were more significant in slow-4. Additionally, changes in slow-4 in both basal ganglia and midbrain correlated with the severity of the @entity304 . The @entity4365 in the caudate nucleus positively correlated with the dose of @entity3034 , while the @entity4365 in the putamen negatively correlated with the disease duration in both slow-4 and slow-5 bands. In addition, the @entity4365 in the rostral supplementary motor area negatively correlated with @entity2845 subscale scores. Our findings show that with a large cohort of @entity1 and distinguishing frequency bands, neural modulations in the brainstem and striatum in @entity191 can be detected and may have clinical relevance. The physiological interpretation of these changes needs to be determined.
