Developmental changes and regional distribution of phospholipase D and base exchange enzyme activities in XXXX brain.

@entity35 @entity2339 @entity71072 @entity5157
Phospholipase D ( @entity71072 ) activity per mg protein of whole homogenate increased 5.1 fold between Embryonic (E) day 17 and Postpartum (P) day 14 and slightly decreased by P 30 days. This was due to the decrease of @entity71072 activity of the P2 fraction. The @entity71072 activity of P2 and P3 fractions increased 11.2 and 6.1 fold respectively between E 17 and P 14. The 3 base exchange enzyme ( @entity5157 ) activities per mg protein of whole homogenate increased up to P 14 or P 21 and then decreased. This decrease was greater in the P2 fraction and the P3 fraction increased after P 14. Brains from 1 day to 25 month old @entity35 were dissected into 7 separate regions and both @entity71072 and @entity5157 activities were measured. In adult @entity35 , the hippocampus and @entity2339 had the highest @entity71072 activities while medulla + pons and cerebellum had the lowest @entity71072 activities. The developmental patterns of 5 regions except for hippocampus and @entity2339 were similar. @entity71072 activity in the hippocampus was maximum at P 7 followed by a steep decrease till P 30 suggesting that the @entity71072 activity of the @entity2339 develops later and that of the hippocampus develops earlier than any other region. The distributions of @entity5157 activities were quite different from those of @entity71072 activities. In adult @entity35 , the cerebellum had the highest activity while the striatum and medulla + pons had the lowest. The @entity5157 activities of cerebellum were lowest at P 1 and showed steep increase during the next 2 weeks.
