Comparison of quantitative stenosis characteristics at routine coronary computed tomography angiography with invasive fractional flow reserve for assessing lesion-specific XXXX .

@entity1 @entity8431 @entity63
OBJECTIVE: To comprehensively evaluate quantitative parameters derived from routine coronary CT angiography (cCTA) for predicting lesion-specific @entity63 in comparison to invasive fractional flow reserve (FFR). BACKGROUND: The ability of cCTA to gauge lesion-specific @entity63 is limited. Several quantitative parameters have been proposed to enhance the specificity of cCTA, such as morphologic indices (lesion length/minimal lumen diameter(4) [LL/ @entity8431 (4)]; percentage aggregate plaque volume [%APV]) and a measure of intracoronary contrast gradients (corrected coronary opacification [CCO]). METHODS: Forty-nine @entity1 who had undergone cCTA followed by FFR within 3  months were included. An experienced observer visually assessed all cCTA studies and derived multiple measures characterizing the lesion of interest, including LL, @entity8431 , minimal lumen area (MLA), LL/ @entity8431 (4), remodeling index, %APV, and CCO. Lesion-specific @entity63 was considered with FFR <0.8. RESULTS: Among 56 lesions, 13 were flow-obstructing by FFR. On univariate analysis, LL, @entity8431 , LL/ @entity8431 (4), and CCO showed discriminatory power. The area under the curve of LL/ @entity8431 (4) (0.909) was significantly greater compared with @entity8431 (0.802, P  =  0.014), LL (0.739, P  =  0.041), and CCO (0.809), although the latter did not reach statistical significance (P  =  0.175). On multivariate regression, LL/ @entity8431 (4) was the only independent predictor of lesion-specific @entity63 (odds ratio 2.021, P  =  0.001). Moreover, LL/ @entity8431 (4) compared favorably to visual cCTA evaluation. CONCLUSION: LL/ @entity8431 (4) derived from routine cCTA can enhance the detection of lesion-specific @entity63 and may be superior to other described quantitative parameters.
