Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life XXXX .

@entity1 @entity162
BACKGROUND: Previous magnetic resonance imaging (MRI) studies in young @entity1 with @entity162 indicated the presence of grey matter concentration changes as well as microstructural alterations in white matter in various neocortical areas and the corpus callosum. Whether these structural changes are also present in elderly @entity1 with @entity162 with long-lasting clinical evolution remains unclear. METHODS: We performed a prospective MRI study of consecutive elderly, euthymic @entity1 with @entity162 and healthy, elderly controls. We conducted a voxel-based morphometry (VBM) analysis and a tract-based spatial statistics (TBSS) analysis to assess fractional anisotropy and longitudinal, radial and mean diffusivity derived by diffusion tensor imaging (DTI). RESULTS: We included 19 @entity1 with @entity162 and 47 controls in our study. Fractional anisotropy was the most sensitive DTI marker and decreased significantly in the ventral part of the corpus callosum in @entity1 with @entity162 . Longitudinal, radial and mean diffusivity showed no significant between-group differences. Grey matter concentration was reduced in @entity1 with @entity162 in the right anterior insula, head of the caudate nucleus, nucleus accumbens, ventral putamen and frontal orbital cortex. Conversely, there was no grey matter concentration or fractional anisotropy increase in any brain region in @entity1 with @entity162 compared with controls. LIMITATIONS: The major limitation of our study is the small number of @entity1 with @entity162 . CONCLUSION: Our data document the concomitant presence of grey matter concentration decreases in the anterior limbic areas and the reduced fibre tract coherence in the corpus callosum of elderly @entity1 with long-lasting @entity162 .
