Protein restriction, glomerular filtration rate and XXXX in @entity1 with @entity6 : a randomized trial.

@entity4444 @entity1 @entity8 @entity6 @entity2316 @entity1009 @entity633 @entity164 @entity1011
OBJECTIVE: Protein restriction delays the progression of non-diabetic and @entity164 1 @entity2316 . This study assessed whether protein restriction delays the onset or early progression of @entity8 in @entity164 2 @entity6 . DESIGN: Randomized controlled trial. Outcomes were @entity633 (mg/24 h) and, as an estimate of the glomerular filtration rate, @entity4444 -influenced @entity1011 clearance. SETTING: Primary care. SUBJECTS: @entity1 with @entity164 2 @entity6 and microalbuminuria or at least detectable @entity633 , or a @entity6 duration >5 y. INTERVENTIONS: The experimental group received dietary counselling on protein restriction (n=63); a control group (n=68) received the usual dietary advice. The duration of intervention and follow-up was 28+/-7 months. RESULTS: After 6 months, protein intake differed only by 0.08 g/kg/day between the study groups. Subsequently, this difference decreased and eventually disappeared. An initial effect of protein restriction on @entity633 in favor of the experimental group was not sustained, and the glomerular filtration rate decreased in the experimental group at a 1.6+/-2.2 ml/ @entity1009 .73 m(2) y lower rate than in the control group (P=0.5). Comparison of @entity1 in the experimental group with a decrease in protein intake of at least 0.20 g/kg/day, with controls with no decrease, indicated a similarly small and insignificant effect on glomerular filtration rate. CONCLUSIONS: It is concluded that, in the longer term prevention or delay of @entity8 in @entity1 with @entity164 2 @entity6 , protein restriction is neither feasible nor efficacious.
