Regulatory T-Cells and Micrometastasis in Lymph Nodes of Stage I XXXX .

@entity1 @entity4166 @entity5 @entity1149 @entity403 @entity792
BACKGROUND: Regulatory T-cells (Tregs) have a pivotal role not only in abrogating @entity792 , but also in @entity5 immune escape. The purpose of the present study was to evaluate the clinical significance of the relative expression of forkhead/winged helix transcription factor ( @entity403 ) and micrometastasis in the regional lymph nodes (RLNs) of @entity1 with stage I @entity1149 ( @entity1149 ). MATERIALS AND METHODS: The RLNs in 131 @entity1 who underwent complete surgical resection for stage I @entity1149 were collected at the time of surgery. The relative expression levels of @entity403 and @entity4166 ( @entity4166 ) in RLNs were determined by quantitative RT-PCR. RESULTS: The pathological stage was diagnosed as stage IA in 97 @entity1 (74.0%) and stage IB in 34 @entity1 (26.0%). The relative expression levels of @entity403 and @entity4166 in the RLNs were 0.062  0.0083% and 0.025  0.056%, respectively. The relative expression of @entity403 tended to increase with increasing relative expression of @entity4166 . The five-year overall survival rate of the @entity1 with low expression of @entity403 was better (90.3%) than that of @entity1 with high expression (79.3%) (p=0.0419). A multivariate analysis using the significant variables (gender, age, histology and @entity403 expression) showed that the @entity403 expression in RLNs was a significant independent prognostic factor. CONCLUSION: The expression of @entity4166 tended to be positively correlated with the expression of @entity403 . High expression of @entity403 in RLNs was a significant unfavorable prognostic factor in @entity1 with stage I @entity1149 .
