Detection of XXXX point mutation at codon 12 in @entity660 : a study in a Brazilian casuistic.

@entity1 @entity788 @entity1124 @entity984 @entity5 @entity660 @entity420
OBJECTIVE: To clarify the sensitivity and the validity of @entity984 point mutational analysis at codon 12 in Brazilian @entity1 with @entity660 , and the possible correlation between the presence of the mutation and the histopathological findings. @entity1 : Ninety-seven Brazilian @entity1 with @entity1124 , @entity788 and chronic @entity788 were enrolled in this study. Forty-five @entity1 (46%) were female and 52 @entity1 (54%) were male, having an average age of 60.2+/-9.2 years for @entity420 (n=52), 45.1+/-19.4 years for @entity788 (n=20), and 46.4+/-11.2 years for chronic @entity788 (n=25). DNA extracted from 11 normal @entity1 peripheric lymphocytes was utilized as a control. RESULTS: The sensitivity of @entity984 mutational analysis was 83.3% (25/30) in paraffin-embedded samples and 72.7% (16/22) in surgically resected specimens of the @entity5 . On the other hand, no mutations were found in @entity788 or in chronic @entity788 . Regarding the histopathological grading, the higher positivity rate was found in poorly-differentiated @entity420 (100%), and progressively decreased in moderately-differentiated @entity420 (72.2%), and well-differentiated @entity420 (66.6%). The positivity rate in non-classified @entity420 was 81.8%. CONCLUSION: @entity984 point mutation, in our study, is notably prevalent in @entity5 and is absent in chronic @entity788 and @entity788 . These results encourage us to consider the possibility of treatment strategies for this oncogene in the future.
