Coffee prevents @entity40656 -induced XXXX in the rat.

@entity1 @entity82 @entity40656 @entity409 @entity2041 @entity6172 @entity3929 @entity1810 @entity1575
PURPOSE: Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and @entity1575 has been reported in @entity1 . However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of @entity409 . METHODS: In this work, @entity82 was induced by chronic @entity40656 administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8  weeks. RESULTS: @entity40656 administration elevated serum alkaline phosphatase and @entity3929 aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and @entity1810 mRNA, and protein levels; depleted liver glycogen and @entity2041 ( @entity6172 ) content. Coffee prevented most of the changes produced by @entity40656 . Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal @entity1810 mRNA and protein levels. CONCLUSIONS: Our results suggest (1) that coffee plays a causative role in preventing @entity82 (at least experimental @entity82 ); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine @entity1810 and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.
