Interhemispheric microstructural connectivity in bitemporal lobe epilepsy with XXXX .

@entity1 @entity131 @entity1625 @entity410 @entity1315 @entity1893 @entity528
UNASSIGNED: @entity1315 ( @entity1315 ) is the most common form of @entity1625 . The most frequent pathologic finding in this condition is @entity131 ( @entity131 ). In addition, in a small proportion (14-23%) of refractory @entity1315 @entity1 , the presence of @entity131 is bilateral. @entity1315 involves grey matter (GM) and white matter (WM) abnormalities in a wide cortico-subcortical network. However, the impact of @entity528 on specific WM fiber pathways and associated functional systems as well as @entity410 propagation pathways remains unclear. There is still much controversy regarding the role of the commissures (corpus callosum, hippocampal commissure and anterior commissure) in interhemispheric @entity410 propagation. This study aimed to investigate the integrity of WM interhemispheric connectivity in a singular sample of @entity1 with @entity1315 and bilateral @entity131 using structural magnetic resonance imaging (MRI). We performed multimodal structural MRI [high resolution T1-weighted and diffusion tensor imaging (DTI)] analyses of seven @entity1 with medically refractory @entity1315 with bilateral @entity131 , fourteen unilateral left @entity1315 @entity1 and fifteen matched healthy individuals. Whole-brain voxel-wise analysis techniques were used. These @entity1 evidenced WM derangement [reduced fractional anisotropy (FA), increased @entity1893 ( @entity1893 ) or reduced WM volume] in temporal and extratemporal tracks, but also in commissural pathways, compared to the unilateral left @entity1315 @entity1 and the control group. Presence of reduced FA or increased @entity1893 in the fornix, cingulum and uncinate fasciculus in addition to reduced WM volume in the fornix was also encountered. Neuropsychological assessment was performed without significant correlations with structural data. The current results support the idea that commissural pathways play a contributory role in interhemispheric @entity1315 @entity410 propagation in bilateral @entity131 and offer new perspectives about the long-term effects on interhemispheric connectivity associated with @entity410 propagation patterns in @entity1315 @entity1 .
