Treatment results of image-guided high-dose-rate interstitial brachytherapy for pelvic recurrence of uterine XXXX .

@entity5 @entity1
PURPOSE: We analyzed clinical data to evaluate the effectiveness of image-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for pelvic recurrence of uterine @entity5 . METHODS AND MATERIALS: Between 2003 and 2011, 56 @entity1 were treated with HDR-ISBT with or without external beam radiotherapy (EBRT). The median followup time was 33 months (range, 1-109 months). Pre-ISBT treatments included radical hysterectomy for 35 @entity1 (Group A), radical hysterectomy with postoperative radiotherapy for 8 @entity1 (Group B), and radical radiotherapy for 13 @entity1 (Group C). We initiated MRI-assisted CT-based planning for the last 49 @entity1 . The median ISBT single fraction dose was 6  Gy. The median total doses were 30 and 54  Gy with and without EBRT (range, 30-50  Gy) for Group A, respectively and 48  Gy without EBRT for Groups B and C. RESULTS: The 3-year local control (LC) rates were 85%, 75%, and 46% for Groups A, B, and C, respectively (p  =  0.017). The 3-year LC rates were 84%, 73%, and 33% for clinical target volume at the time of HDR-ISBT of <10, 10-29, and >= 30  cc, respectively (p  =  0.005). The 3-year LC results tended to be higher for @entity1 whose D100 (clinical target volume) was equal or higher than 67.1  Gy (p  =  0.098). A total of 13 late complications of Grades 3-5 occurred in 11 @entity1 (20%). CONCLUSIONS: Our image-guided HDR-ISBT for pelvic recurrence of uterine @entity5 provided good treatment outcomes. The treatment results for @entity1 who underwent radical surgery with or without postoperative radiotherapy are better than those for @entity1 who underwent radical radiotherapy.
