@entity4854 during hypothermic @entity235 cardiopulmonary bypass increases cerebral XXXX .

@entity235 @entity6546 @entity26 @entity48950 @entity1602 @entity880 @entity4854 @entity413 @entity4202
BACKGROUND: @entity4854 frequently occurs during cardiopulmonary bypass (CPB), although its direct effects on cerebral perfusion and metabolism are not known. Using a @entity235 model of hypothermic CPB, we tested whether @entity4854 alters cerebral blood flow and metabolism and cerebral energy charge. METHODS: Twenty anesthetized @entity235 were randomized into @entity1602 (n = 10) and normoglycemic (n = 10) groups. The @entity1602 group received an infusion of D50W, and the normoglycemic animals received an equal volume of 0.9% @entity4202 . Both groups underwent 120 min of hypothermic (28 degrees C) CPB using membrane oxygenators, followed by rewarming and termination of CPB. Cerebral blood flow (radioactive microspheres) and the cerebral metabolic rate for @entity26 were measured intermittently during the experiment and brain tissue metabolites were obtained after bypass. RESULTS: Before CPB, the @entity413 -treated animals had higher serum @entity413 levels (534 +/- 12 mg/dL; mean +/- SE) than controls (103 +/- 4 mg/dL; P < 0.05), and this difference was maintained throughout the study. Cerebral blood flow and metabolism did not differ between groups at any time during the experiment. @entity48950 was comparable between groups throughout CPB. Tissue high-energy @entity6546 and water contents were similar after CPB, although cerebral @entity880 levels were greater in @entity1602 (37.2 +/- 5.7 mumol/g) than normoglycemic animals (19.7 +/- 3.7 mumol/g; P < 0.05). After CPB, pH values of cerebrospinal fluid for normoglycemic (7.33 +/- 0.01) and @entity1602 (7.34 +/- 0.01) groups were similar. CONCLUSIONS: @entity4854 during CPB significantly increases cerebral @entity880 levels without adversely affecting cerebral blood flow and metabolism, cerebrospinal fluid pH, or cerebral energy charge.
