Nanoscale and customary non-esterified sitosterols are equally enriched in different body compartments of the XXXX .

@entity9542 @entity844 @entity840 @entity5932 @entity5068 @entity165
The impact of @entity9542 formulation particle size on the intestinal @entity5068 absorption and the @entity5068 status in various tissues in Dunkin Hartley @entity840 was investigated. Three groups of animals (six each) were fed a basal diet ("control") or a basal diet containing either customary @entity9542 ("customary", particle size: 10 000-90 000 nm) or nanoscale @entity9542 ("nanoscale", particle size: 200-300 nm). The average daily @entity9542 intake was 21 +/- 7 mg (control), 154 +/- 8 mg (customary), and 127 +/- 18 mg (nanoscale) for 2 weeks. @entity9542 and @entity165 were analyzed in samples of plasma, blood cells, bile, liver, kidney, @entity5932 , cecum, colon and feces. Concentrations of @entity9542 in all analyzed matrices increased significantly in the supplemented groups when compared to control group. No differences in the @entity9542 concentrations in analyzed matrices occurred between nanoscale and customary group. The @entity165 concentrations in tissues remained unchanged. Fecal @entity844 and @entity5068 distributions were modified during @entity9542 intervention. Both particle sizes equally increased @entity9542 levels in @entity165 -metabolizing compartments in the @entity840 . No differences in body compartment accumulation and intestinal absorption of the different @entity9542 particle sizes were observed.
