Systemic XXXX and lung function: A longitudinal analysis.

@entity1 @entity32 @entity2002 @entity73 @entity358 @entity1851
BACKGROUND: Systemic @entity32 is associated with @entity73 in healthy adults as well as in @entity1 with @entity358 . The mechanism for this association is unknown and it is unclear if systemic @entity32 leads to @entity73 or if poor lung function leads to @entity32 . We explored the temporal associations between blood @entity1851 ( @entity1851 ), @entity2002 , and white blood cells, and lung function in young adults. METHODS: Spirometry, plethysmography, and diffusion capacity were measured in a population-based cohort at ages 32 and 38 years. High-sensitivity @entity1851 , @entity2002 , and white blood cells were measured at the same ages. RESULTS: Higher levels of @entity1851 and, to a lesser extent, @entity2002 were associated with lower lung volumes in cross-sectional analyses at both ages 32 and 38 years. Higher @entity1851 and @entity2002 at age 32 were associated with higher FEV1 and FEV1/FVC at age 38, but not other measures of lung function. Lower lung volumes (total lung capacity, functional residual capacity, and residual volume) but not airflow obstruction (FEV1/FVC) at age 32 were associated with higher @entity1851 at age 38. Associations between age 32 lung function and @entity2002 at follow-up were weaker, but consistent. There were no longitudinal associations between white blood cells and lung function. CONCLUSIONS: We found no evidence that systemic @entity32 causes a decline in lung function. However, lower lung volumes were associated with higher @entity1851 and @entity2002 at follow-up indicating that pulmonary restriction may be a risk factor for systemic @entity32 . The mechanism for this association remains unclear.
