Late effects of XXXX therapy in childhood in relation to the function of the heart at rest and under physical stress.

@entity1 @entity64 @entity8253 @entity4349 @entity1370
To evaluate the long-term effects of @entity8253 on the myocardium of the young @entity1 we examined 34 @entity1 who had been treated with @entity8253 in childhood. In addition to @entity4349 , the @entity1 were treated with other potentially @entity1370 substances within the framework of different protocols. The mean cumulative @entity4349 dose was 128.6 mg/m2, the average age at onset of chemotherapy 4.2 years, and the time interval after discontinuation of treatment 9.0 years. The cardiological examination consisted of a physical examination, electrocardiography and echocardiography, including Doppler and bio-impedance cardiography. The @entity1 were studied at rest and after physical exercise with a cycle ergometer test in a supine position. The results of the physical examination, the electrocardiogram at rest and the 24 h Holter monitoring were normal. The left ventricular enddiastolic diameter, shortening fraction, velocity of fibre shortening (VCF), the diastolic flow profile at the mitral valve level and the @entity64 at rest were also normal. However, the shortening fraction (SF) was below the margin of 2 standard deviations in two @entity1 and the VCF in three @entity1 . There was a significant reduction in septal thickness, (-1.4 SD, P < 0.0004), in the width of left ventricular posterior wall (-1.5 SD, P > 0.0002) and in the left ventricular myocardial mass (-0.76 SD, P = 0.0042). Physical working capacity was normal. Immediately after physical stress the expected rise of SF and VCF did not occur and the SF fell below the values at rest. In comparison to a healthy control group the SF and the VCF were markedly decreased (P > 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
