Comparative effects of @entity1286 on leukocytic antigenic markers of monkeys and XXXX .

@entity2608 @entity1 @entity3138 @entity1286
Knowing the in vitro effects of @entity1286 on monkey leukocytes would be helpful in extending the utility of a monkey model for psychoneuroimmunological investigations. @entity1286 effects on @entity3138 , Leu2a, and Leu3a antigenic markers on leukocytes from @entity2608 and @entity1 were assessed by using single- and two-color cytofluorometric analyses. Kinetics of expression of these markers was determined after modulation of the original complement of @entity3138 markers from the surface of @entity3138 (+) cells. Percentages of leukocytes detectable by directly staining these markers before modulation were within the expected range for monkey and @entity1 cells. Also, as expected, @entity3138 modulation reduced the percentages of cells expressing @entity3138 . This reduction was particularly obvious for @entity3138 in the single-color analyses, with reductions being greater for monkey than @entity1 cells. Furthermore, in the single-color analyses, the effects of @entity1286 on kinetics of @entity3138 expression were quite similar for both @entity1 and monkey cells. In the two-color analyses, the simultaneous expression of @entity3138 and Leu3a markers was uniform for both monkey and @entity1 cells. The effects of @entity1286 on kinetics of expression of these markers varied only slightly between species. On the other hand, the distribution of Leu2a on @entity3138 cells was markedly different for monkey and @entity1 T-cells. Whereas all @entity1 Leu2a(+) cells expressed similar numbers of @entity3138 receptors, monkey cells with high-density Leu2a expressed fewer @entity3138 markers than those with low-density Leu2a. The effects of @entity1286 on kinetics of Leu2a and @entity3138 expression were at obvious variance between species.(ABSTRACT TRUNCATED AT 250 WORDS)
