Eosinopenia as a Marker of Outcome in Acute Exacerbations of XXXX .

@entity1 @entity204 @entity1030
BACKGROUND: Acute exacerbation of @entity1030 (AECOPD) is a common cause of hospitalization and mortality. Recent studies have shown the usefulness of eosinopenia in predicting the outcomes of @entity1 admitted to the intensive care unit. This study examined the association of eosinopenia with the outcomes of @entity1 with AECOPD. METHODS: This is a prospective study. @entity1 with AECOPD were divided into two cohorts: @entity1 with eosinopenia and those without eosinopenia. Duration of hospitalization, need of mechanical ventilation, in-hospital mortality, rehospitalization, or @entity204 within 30 days after discharge were compared between the two cohorts. Eosinopenia was defined as eosinophil count of >40 cells/mm(3). RESULTS: Among 100 @entity1 with AECOPD, 44 were eosinopenic and 56 were non-eosinopenic. Duration of hospitalization of @entity1 with eosinopenia was 12.38    9.85 days and that of @entity1 without eosinopenia was 7.35    5.68 days (p = 0.001). In all, 16 (36%) @entity1 with eosinopenia and seven (12%) @entity1 without eosinopenia needed mechanical ventilation (p = 0.005). In-hospital mortality rate among eosinopenic and noneosinopenic @entity1 was 37.5% (12/44) and 7.6% (4/56), respectively (p = 0.006). Among 100 @entity1 with AECOPD, 16 died in the hospital. Of these, 12 (27.27%) were eosinopenic and 4 (7.6%) were noneosinopenic (p = 0.006). The mean eosinophil count of @entity1 who died in the hospital (n = 16) was 44.00 cells/ml whereas that of survivors (n = 84) was 107.41 cells/ml (p = 0.022). CONCLUSION: We conclude that a significant relationship exists between eosinopenia and outcomes of @entity1 with AECOPD. Thus, eosinopenia can be a useful, easy-to-measure, and inexpensive biomarker for predicting the prognosis of @entity1 with AECOPD.
