Intraoperative Molecular Imaging of Lung @entity420 Can Identify XXXX Cells at the Surgical Margins.

@entity1501 @entity1 @entity41 @entity19 @entity5 @entity420 @entity2220
PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to @entity420 could enhance @entity41 during resection. PROCEDURES: @entity19 with @entity5 received a contrast agent targeting @entity1501 receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three @entity1 with @entity2220 . RESULTS: The peak @entity5 -to-background ratio (TBR) of @entity19 @entity5 was 3.9. Fluorescence peaked at 2  h and was not improved beyond 0.1  mg/kg. Traditional inspection identified 30  % of @entity19 with positive margins. Molecular imaging identified an additional 50  % of @entity41 deposits (p   <   0.05). The fluorescent probe visually enhanced all @entity1 @entity5 with a mean TBR of 3.5. CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after @entity5 resection.
