@entity51914 associated with XXXX : a possible role for @entity4878 in therapy.

@entity1 @entity4878 @entity51914 @entity8889 @entity3067 @entity792 @entity554
A @entity51914 ( @entity51914 ) may be localized or diffuse. It may also be congenital or acquired. Development of diffuse BFHs has been associated with @entity792 and with the development of @entity3067 . Two @entity1 with @entity792 had @entity3067 develop. We present the histologic features of @entity51914 seen in these 2 @entity1 using vertical and transverse sections, and the response of 1 @entity1 to @entity554 therapy. Histologic sections showed a hamartomatous proliferation of hair follicles involving the majority of their hairs. The hamartomatous follicles showed variable degrees of hair differentiation. One @entity1 , treated with oral and then topical @entity4878 , showed a partial regrowth of scalp hair and some regression of the cutaneous nodules. Increased sonic hedgehog signaling pathways with increased @entity8889 transcription has been shown to be present in the spectrum of follicular hamartomatous changes seen in BFHs. This may explain the response of one @entity1 to @entity554 therapy, because @entity4878 decrease @entity8889 transcriptional activity.
