Magnetic Resonance Imaging in the Evaluation of Clinical Treatment of XXXX : A Pilot Study.

@entity1 @entity3163 @entity75 @entity8719 @entity561 @entity2287
OBJECTIVES: To evaluate the applicability of magnetic resonance imaging (MRI) as a method for monitoring the activity of @entity75 before and after clinical treatment. STUDY DESIGN: Prospective, randomized, controlled, double-blind study. SETTING: One single tertiary care institution in a large, cosmopolitan city. METHODS: Twenty-six @entity1 (n = 42 ears) with clinical, audiometric, and tomographic diagnosis of @entity8719 were enrolled. If computed tomography (CT) demonstrated active lesions, these @entity1 underwent MRI to detect otospongiotic foci, seen as areas of @entity2287 enhancement. @entity1 were divided into 3 groups and received treatment with placebo, @entity561 , or @entity3163 for 6 months. After this period, clinical and audiometric evaluations and a second MRI were performed. Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective (visual) and objective (using specific eFilm Workstation software) manner. RESULTS: @entity8719 was most predominantly identified in the region anterior to the oval window, and this site was reliable for comparing pre- and posttreatment scans. The @entity1 in the @entity561 and @entity3163 groups had MRI findings that suggested a decrease in activity of @entity75 , more relevant in the @entity561 group. These findings were statistically significant for both subjective and objective MRI evaluations. CONCLUSIONS: MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of @entity8719 . The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in @entity8719 .
