Effect of @entity172 and XXXX blocker on @entity8233 formation.

@entity172 @entity691 @entity1603 @entity14207 @entity19 @entity10433 @entity53 @entity9885 @entity13436 @entity1317 @entity16279 @entity8233
The present study explored the possibility that @entity172 may enhance the inhibitory effect of an @entity14207 blocker on @entity8233 formation in @entity1317 , and investigated the signaling mechanism involved in their actions. @entity691 cuff placement around the femoral artery of @entity19 induced @entity8233 formation and increased @entity1603 ( @entity1603 ) incorporation into vascular smooth muscle cells. These changes were significantly smaller in female @entity19 than in male @entity19 . Ovariectomy enhanced @entity8233 formation and @entity1603 incorporation in the injured artery, which were reversed by @entity53 (80 microg/kg per day) replacement. Treatment with a selective @entity14207 blocker, @entity9885 (3 mg/kg per day), significantly inhibited @entity8233 formation and @entity1603 incorporation, whereas the inhibitory effects of @entity9885 were more marked in intact female @entity19 than in male or ovariectomized @entity19 . Phosphorylation of @entity13436 ( @entity13436 ), @entity16279 , and @entity10433 was increased in the injured artery. These increases were significantly smaller in intact female @entity19 than in male or ovariectomized @entity19 . @entity9885 or @entity172 attenuated the phosphorylation of @entity13436 and STAT in the injured artery, whereas these inhibitory effects were greater in intact female @entity19 . Lower doses of @entity9885 (0.5 mg/kg per day) or @entity53 (20 microg/kg per day) did not influence @entity8233 formation, @entity1603 incorporation, and @entity13436 and STAT phosphorylation in ovariectomized @entity19 , whereas coadministration of @entity9885 and @entity53 at these doses attenuated these parameters. These results indicate that @entity172 and an @entity14207 blocker synergistically attenuate vascular remodeling, which is at least partly via inhibition of @entity13436 and STAT activity.
