Geriatric conditions, medication use, and risk of XXXX in a predominantly male, older veteran population.

@entity1 @entity227 @entity137 @entity308 @entity322 @entity73 @entity1142
OBJECTIVES: To determine whether geriatric conditions and functional impairment are independent risk factors for @entity137 ( @entity137 ). DESIGN: Prospective cohort study. SETTING: Veterans Affairs Medical Center. @entity1 : Three hundred seventy-seven veterans aged 65 and older and taking five or more medications. MEASUREMENTS: Geriatric conditions and functional status were assessed using @entity1 interviews and structured assessments at study baseline. @entity137 were elicited during @entity1 interviews 3 and 12 months after study enrollment using validated methods. RESULTS: The strong majority (97%) of @entity1 were male, with a mean age of 74    5; 123 (33%) had one or more dependencies in instrumental activities of daily living (IADLs). Over the 1-year study period, 126 @entity1 (33%) developed 167 @entity137 . Upon multivariable analysis, risk of @entity137 was not associated with any of the geriatric conditions that there was sufficient power to evaluate, including IADL function, @entity73 , @entity308 , @entity227 , @entity322 , @entity1142 , and a summative measure of geriatric burden comprising the above and history of falls or gait instability. In exploratory analyses, the strongest factor associated with @entity137 was the number of drugs added to a @entity1 's medication regimen during the 1-year study period (incidence rate ratio 1.11 per each added drug, 95% confidence interval=1.03-1.19). CONCLUSION: Common geriatric conditions and IADL function were not associated with @entity137 in a predominantly male, older veteran population. Although it is important to consider the unique circumstances of each @entity1 , excessive caution in prescribing to older adults with these geriatric conditions may not be warranted.
