Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in XXXX .

@entity1 @entity296 @entity452 @entity35107
BACKGROUND: Low dose @entity452 stress magnetic resonance imaging is valuable to assess viability in @entity1 with @entity296 . Analysis is usually qualitative with considerable operator dependency. The aim of the current study was to investigate the feasibility of cine images derived quantitative cardiac magnetic resonance (CMR) myocardial feature tracking (FT) strain parameters to assess viability in @entity1 with @entity296 . METHODS: 15 consecutive @entity1 with @entity296 referred for viability assessment were studied at 3T at rest and during low dose @entity452 stress (5 and 10 g/kg/min of @entity452 ). Subendocardial and subepicardial circumferential (Eccendo and Eccepi) and radial ( @entity35107 ) strains were assessed using steady state free precession (SSFP) cine images orientated in 3 short axis slices covering 16 @entity296 . RESULTS: Dysfunctional segments without scar (n=75) improved in all three strain parameters: Eccendo (Rest: -10.5  6.9; 5 g: -12.1  6.9; 10 g: -14.1  9.2; p<0.05), Eccepi (Rest: -7  4.8; 5 g: -8.2  5.5; 10 g: -9.1  5.9; p<0.05) and @entity35107 (Rest: 11.7  8.3; 5 g: 16  10.9; 10 g: 16.5  12.8; p<0.05). There was no response to @entity452 in dysfunctional segments with scar transmurality above 75% (n=6): Eccendo (Rest: -4.7  3.0; 5 g: -2.9  2.5; 10 g: -6.6  3.3; p=ns), Eccepi (Rest: -2.9  2.9; 5 g: -5.4  3.9; 10 g: -4.5  4.2; p=ns) and @entity35107 (Rest:9.5  5; 5 g:5.4  6.2; 10 g:4.9  3.3; p=ns). Circumferential strain (Eccendo, Eccepi) improved in all segments up to a transmurality of 75% (n=60; p<0.05). @entity35107 improved in segments <50% transmurality (n=45; p<0.05) and remained unchanged above 50% transmurality (n=21; p=ns). CONCLUSIONS: CMR-FT is a novel technique, which detects quantitative wall motion derived from SSFP cine imaging at rest and with low dose @entity452 stress. CMR-FT holds promise of quantitative assessment of viability in @entity1 with @entity296 .
