Determinants of change in total XXXX and HDL-C with age: the Framingham Study.

@entity1 @entity172 @entity28 @entity167 @entity5 @entity65 @entity165
OBJECTIVE: The purpose of the study was to assess the determinants of change of total @entity165 and high density lipoprotein @entity165 (HDL-C) change in an adult population. METHODS: The prospective cohort was examined at baseline and eight years later. A total of 2,222 @entity1 and 2,677 @entity1 age 20-79 years at baseline were included. Analyses were performed in 15-year age groups, and @entity1 with @entity65 or @entity5 during the observation period were excluded. RESULTS: In longitudinal analyses, body mass index (BMI) and plasma total @entity165 levels of each rose in concert among younger age groups, whereas levels declined in older individuals. Mean levels of BMI and total @entity165 peaked at a later age in @entity1 than in @entity1 . The corresponding changes in HDL-C were negative at all ages, and greater declines were seen in the elderly. A decrease in plasma total @entity165 was highly associated with greater age and a decrease in body mass index over the study interval, whereas the decline in HDL-C was proportional to change in body mass index. These changes remained significant after adjustment for baseline age and change in @entity167 intake, cigarette consumption, diuretic use, and oral @entity172 use. CONCLUSIONS: The rise in plasma total @entity165 among apparently healthy young @entity1 and @entity1 and its fall in the elderly are significantly associated with similar trends for @entity28 . The key determinants of a decline in HDL-C are an increase in @entity28 and advancing age itself. A decline in total @entity165 and in HDL-C is particularly common among the elderly, and it can be expected to occur without specific dietary or pharmacologic intervention.
