Altered tail-skin temperature responsiveness in @entity3839 -induced XXXX @entity35 .

@entity35 @entity6 @entity3839 @entity3044 @entity413
We evaluated the tail-skin temperature response to administration of several doses of @entity3044 in @entity3839 -induced @entity6 @entity35 after 48 h and after 4 weeks of @entity6 . Blood @entity413 concentrations were significantly increased over controls 48 hours after administration of @entity3839 (65 mg/kg, i.v.) and remained elevated to a similar degree in the 4-week group. Basal rectal temperature and tail-skin temperature (TST) were not different between controls and the @entity6 groups and were not affected by administration of saline. However, administration of @entity3044 (25 micrograms/kg, s.c.) caused a significant rise in TST in the control group, but not in the @entity35 @entity6 for 4 weeks. A similar but exaggerated response was observed in the controls after subcutaneous administration of 40 micrograms/kg and 100 micrograms/kg of @entity3044 . The TST response in the 4-week @entity6 @entity35 still remained negligible with the two higher doses of @entity3044 . When the data were summarized as area under the TST curve, a dose-dependent increase was observed in the control groups and a significant absence of response was observed in the 4-week group. The @entity35 studied 48 h after @entity3839 injection had a similar TST response to the control group after administration of 40 micrograms/kg of @entity3044 . Colonic temperatures did not significantly change between the two groups in any of the studies, although the colonic temperatures tended to rise in the control groups following administration of @entity3044 . We conclude from this study that the absence of a tail-skin temperature response in @entity35 @entity6 for 4 weeks results from either a reduced beta-adrenergic receptor mediated response or an altered neural thermoregulatory reflex response, or both. These changes are probably not due to @entity3839 treatment or increases in blood @entity413 .
