Matched follow-up study of 5-8 year old ICSI-singletons: comparison of their neuromotor development to XXXX and naturally conceived singletons.

@entity52 @entity1 @entity51
BACKGROUND: Intracytoplasmic sperm injection (ICSI) is an invasive technique of artificial reproduction. We investigated the effect of ICSI on neuromotor development in 5-8 year old singletons. METHODS: We did a follow-up of ICSI-singletons born between 1996 and 1999 after treatment in the Leiden University Medical Center and compared them with matched controls born after @entity52 ( @entity52 ) and natural conception (NC). @entity1 underwent a thorough neurological examination that focused on minor @entity51 (MND). RESULTS: There were no differences in outcome between ICSI (n = 81) and @entity52 - @entity1 (n = 81), all born at term: MND prevalence 66.3% versus 61.3%, prevalence ratio (PR) 1.08 [0.83; 1.29]. MND prevalence among all ICSI- @entity1 (n = 87) was higher than among NC-controls (n = 85) (66.3% versus 50.6%, PR 1.31 [1.02; 1.55]). After adjustment for maternal age and parity, the PR remained elevated but was no longer statistically significant (adjusted PR 1.22 [0.86; 1.52]). When comparing only term ICSI and NC- @entity1 (n = 81; n = 85), the PR adjusted for maternal age and parity was 1.20 [0.83; 1.51]. CONCLUSIONS: Neuromotor outcome of 5-8 year old singletons born at term after ICSI or @entity52 was similar; ICSI- @entity1 (both the total group and term @entity1 only) deviated slightly from NC-controls. Part of this effect was explained by a difference in parity, but not prematurity.
