Noninvasive assessment of XXXX microenvironment using dynamic contrast-enhanced magnetic resonance imaging and @entity9241 positron emission tomography imaging in neck nodal metastases.

@entity1 @entity135 @entity8984 @entity5 @entity9241 @entity519
PURPOSE: To assess noninvasively the @entity5 microenvironment of neck nodal metastases in @entity1 with @entity135 by investigating the relationship between @entity5 perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and @entity519 measured by @entity9241 ( @entity8984 -FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed @entity135 @entity1 with metastatic neck nodes underwent DCE-MRI and @entity8984 -FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from @entity8984 -FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with @entity8984 -FMISO uptake and nodes with no @entity9241 uptake using Mann-Whitney U tests. RESULTS: For the 13 @entity1 , a total of 18 nodes were analyzed. The nodal size strongly correlated with the @entity8984 -FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the @entity8984 -FMISO SUV. @entity519 nodes (moderate to severe @entity9241 uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no @entity9241 uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, @entity519 nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.
