In the pubertal XXXX , the regulation of ovarian function involves the synergic participation of the sensory and sympathetic innervations that arrive at the gonad.

@entity1420 @entity2951 @entity53 @entity2670 @entity35 @entity479
BACKGROUND: The present study investigates sectioning the superior @entity2670 (SON) in @entity35 with functional sensorial denervation induced by @entity2951 administration at birth and the effects on the establishment of puberty, ovulation, serum @entity1420 , and @entity53 concentrations. METHODS: The animals were allotted randomly to one of the following experimental groups. Groups of 8-10 @entity35 were injected at birth with @entity2951 or vehicle, and on day 20 or 28 of life, they were submitted to a sham operation (SO). Other groups of 8-10 @entity35 were injected at birth with @entity2951 or vehicle, and on day 20 or 28 of life, they were submitted to the uni-or bilateral SON sectioning. The animals were killed at the first estrus. Serum concentration of @entity1420 (ng/ml) and @entity53 (pg/ml) were measured using a radioimmunoassay. RESULTS: Animals treated with @entity2951 and subjected at 20  days of life to the left or bilateral section of SON had a delayed age of vaginal opening. Furthermore, animals with a lack of sensory information and subjected to a SO at 28  days of life had the same delay in the age of vaginal opening. Animals with sensorial innervation intact, subjected to unilateral section of the SON at 20 or 28  days of age, showed diminished ovulation rate and number of ova shed by the denervated ovary. In animals with sensorial denervation, the uni-or bilateral sectioning of the SON did not result in changes in ovulation. @entity1420 and @entity53 levels were different depending on the age of the animal in which the SON section was performed. CONCLUSIONS: Based on the present results, we suggest that sympathetic innervation regulates ovulation and the secretion of @entity479 hormones and that the sensory fibers modulate the sympathetic innervation action on ovarian functions.
