Validity of Optical Coherence Tomography as a Diagnostic Method for @entity6 and XXXX .

@entity1 @entity6 @entity1103 @entity989
UNASSIGNED: To validate optical coherence tomography (OCT) for the diagnosis of referable @entity989 (severe, very severe or @entity989 , and @entity1103 ) in @entity6 @entity1 .We performed a cross-sectional observational study. A random sample was analyzed comprising 136 eyes of @entity6 @entity1 referred to the hospital in Elche (Spain) with suspected referable @entity989 between October 2012 and June 2013. Primary variable: Referable @entity989 measured by ophthalmological examination of the retina. OCT data included: central foveal thickness, presence of intraretinal fluid, and fundus photographs. The receiver operating characteristic (ROC) curve was calculated to determine the minimum thickness value with a positive likelihood ratio >10. To determine the validity of OCT, the following diagnostic test was defined: Positive: if the @entity1 had at least 1 of these criteria: foveal thickness greater than the point obtained on the previously defined ROC curve, intraretinal fluid, abnormal fundus photographs; Negative: none of the above criteria. Sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and Kappa statistic were determined.Of the 136 eyes, 48 had referable @entity989 (35.3%, 95% confidence interval [CI]: 27.3-43.3). The minimum thickness value with a positive likelihood ratio >10 was 275 m. The diagnostic test constructed showed: sensitivity, 91.67% (95% CI: 79.13-97.30); specificity, 93.18% (95% CI: 85.19-97.20); positive predictive value, 88.00% (95% CI: 75.00-95.03); negative predictive value, 95.35% (95% CI: 87.87-98.50); positive likelihood ratio, 13.44 (95% CI: 6.18-29.24); negative likelihood ratio, 0.09 (95% CI: 0.03-0.23). The Kappa value was 0.84 (95% CI: 0.75-0.94, P<0.001.This study constructed a diagnostic test for referable @entity6 with type A evidence. Nevertheless, studies are needed to determine the validity of this test in the general @entity6 population.
