Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and XXXX : a 6-year longitudinal study in @entity1 with @entity6 .

@entity1 @entity4798 @entity101 @entity6 @entity73 @entity62
BACKGROUND: Progression of silent @entity4798 (SBIs) and @entity62 ( @entity62 ) seen on brain MRI is associated with an increased risk of @entity73 , but their relation to endothelial and inflammatory markers is unknown in @entity6 . METHODS: In 190 type 2 @entity6 outpatients (mean age 62.7_emsp14;years), the authors related baseline levels of soluble intercellular adhesion molecule-1 (sICAM-1) and high-sensitivity C-reactive protein (hs-CRP) to subsequent brain MRI findings and cognitive function. The authors assessed incident SBIs and changes in periventricular and subcortical @entity62 (PVWMLs and SCWMLs) on MRI performed at baseline and 3 and 6 years. Neuropsychological tests were administered to 83 @entity1 older than 65 years at 6 years. This present study represents an extension of the authors' previously published study. RESULTS: SBIs were observed in 46 @entity1 (24.2%), PVWMLs in 93 (48.9%) and SCWMLs in 87 (45.8%) on baseline MRI. After adjustment for age, gender, @entity101 , duration of @entity6 , baseline MRI findings and medication use, the relative odds associated with a 1SD increase in sICAM-1 levels at baseline were 1.67 (95% CI 1.02 to 3.05) for SBI progression and 2.17 (95% CI 1.29 to 3.62) for PVWML progression at 6 years. In contrast, baseline hs-CRP levels were significantly associated with SBI progression only at 3 years. Significant trends were observed between quartiles of sICAM-1 at baseline and scores in Digit Symbol substitution (p for trend=0.01). CONCLUSIONS: The findings suggest that higher sICAM-1 levels are associated with SBI and PVWML progression, and may predict @entity73 .
