Transient Generalized Glucocorticoid XXXX .

@entity1 @entity4545 @entity4738 @entity2270 @entity699 @entity2339 @entity56 @entity701 @entity395 @entity6192
BACKGROUND: Transient Generalized Glucocorticoid @entity56 is a @entity395 characterized by increased tissue sensitivity to glucocorticoids and compensatory hypoactivation of the @entity2339 . The condition itself and the underlying molecular mechanisms have not been elucidated. OBJECTIVE: To present the clinical manifestations, endocrinologic evaluation and transcriptomic profile in a @entity1 with Transient Generalized Glucocorticoid @entity56 . DESIGN AND RESULTS: A 9-year old @entity1 presented with an 8-month history of clinical manifestations suggestive of @entity699 . Endocrinologic evaluation revealed undetectable 08:00h @entity4545 (<1 pg/mL) and @entity701 (0.025  g/dL) concentrations, which remained decreased throughout the 24h period and did not respond to stimulation with ovine @entity6192 . The disease gradually resolved spontaneously over the ensuing 3 months. Sequencing of the @entity1 @entity4738 gene revealed no mutations or polymorphisms. Western Blot analysis in peripheral blood mononuclear cells revealed equal protein expression of hGRa of the @entity1 in the disease and post resolution phases compared with a control subject. Transcriptomic analysis in peripheral blood mononuclear cells in the disease and post resolution phases identified 903 differentially expressed genes. Of these, 106 genes were up-regulated and 797 were down-regulated in the disease compared with the resolution phase. Bioinformatics analysis on the differentially expressed gene networks revealed Nuclear Factor-kB as the predominant transcription factor influencing the expression of the majority of differentially expressed genes. CONCLUSIONS: Our findings indicate that a transient post-receptor defect, or a virus- or bacterium-encoded molecule may have enhanced glucocorticoid signal transduction, leading to transient generalized glucocorticoid @entity56 and @entity2270 . This article is protected by copyright. All rights reserved.
