Glomerulopathy in spontaneously @entity6 XXXX . Impact of glycemic control.

@entity644 @entity6 @entity2316 @entity35 @entity631 @entity1602
The spontaneously @entity6 BioBreeding/Worcester (BB/W) @entity35 was used to examine the role of glycemic control in the pathogenesis of @entity2316 and @entity644 . Nondiabetic BB/ @entity35 (group 1) were compared with moderately (group 2) and severely (group 3) @entity1602 @entity6 animals of similar age. Urinary protein excretion and morphometric measurements of @entity631 ( @entity631 ) width and mesangial area were performed after 4, 8, and 12 mo of study. At 4 mo, urinary protein excretion both in group 2 (9.3 +/- 0.7 mg/24 h) and group 3 (24.8 +/- 1.98 mg/24 h) exceeded that in group 1 (5.4 +/- 0.6 mg/24 h; P less than .05). Moreover, @entity644 in group 3 was significantly greater than in group 2 (P less than .05). In addition, @entity644 increased in group 3 animals between 4 and 12 mo of study but did not advance in groups 1 or 2. @entity631 width in both @entity6 groups (168.8 +/- 2.4 and 165.7 +/- 2.2 nm, groups 2 and 3, respectively) exceeded that in group 1 (148.3 +/- 3.8 nm; P less than .01) by 4 mo. At 12 mo, severely @entity1602 group 3 animals had significantly greater @entity631 thickening than group 2. @entity631 width increased in all three groups over the course of study, but the rate of growth did not differ between groups 1 and 2. However, the rate of growth in group 3 was greater than in either group 1 or group 2. Urinary protein excretion correlated significantly with @entity631 width in @entity6 @entity35 .(ABSTRACT TRUNCATED AT 250 WORDS)
