Distribution and Determinants of Plasma XXXX Levels in Rural Chinese Twins across the Lifespan.

@entity1 @entity9770 @entity9769 @entity1255 @entity5784 @entity209 @entity65
Plasma @entity1255 ( @entity5784 ) is a modifiable, independent risk factor for @entity65 ( @entity65 ) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10-66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of @entity1 had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among @entity1 , male adults and female adults, respectively. The @entity9769 @entity9770 variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the @entity1 and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of @entity65 and @entity209 .
