Epidemiology and clinical features of XXXX in Nagasaki, Japan.

@entity1 @entity4594 @entity358 @entity3069 @entity378
BACKGROUND AND OBJECTIVES: Recent reports indicate that the incidence of nontuberculous @entity358 (NTM-LD) is increasing. This study aimed to investigate the epidemiology and clinical features of NTM-LD @entity1 in Nagasaki prefecture, Japan to identify the negative prognostic factors for NTM-LD in Japan. METHODS: The medical records of @entity1 newly diagnosed with NTM-LD in eleven hospitals in Nagasaki prefecture between January 2001 and February 2010 were reviewed. Data regarding the annual population of each region and the incidence of all forms of @entity378 were collected to assess geographic variations in NTM-LD incidence, isolates, and radiological features. RESULTS: A total 975 @entity1 were diagnosed with NTM-LD. The incidence increased over the study period and reached 11.0 and 10.1 per 100,000 population in 2008 and 2009, respectively. @entity4594 was the most common pathogen in the southern region, and @entity3069 most common in other regions. The most common radiographic pattern was the nodular-bronchiectatic pattern. Age >60 years, body mass index <18.5 kg/m2, underlying @entity358 , and cavitary pattern were the negative prognostic factors at the 1-year follow-up. CONCLUSIONS: The incidence of NTM-LD has been increasing in Nagasaki prefecture. The isolates and radiographic features of @entity1 vary markedly by region.
