Prevention of XXXX by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans.

@entity1 @entity694 @entity5 @entity14
OBJECTIVE: To determine whether @entity1 with @entity14 are less likely than unaffected controls to have had one or more endoscopic procedures (flexible sigmoidoscopy, colonoscopy, or polypectomy) before being diagnosed with @entity5 . DESIGN: Case-control study. SETTING: Hospitals of the Department of Veterans Affairs. @entity1 : 8722 and 7629 case- @entity1 with @entity694 , respectively, and age-, sex-, race-matched controls who were discharged at the same time as the corresponding case- @entity1 . MEASUREMENTS: Number and type of endoscopic procedures of the large bowel done from 1981 until the development of @entity14 in each case- @entity1 . The influence of endoscopic procedures on the development of @entity14 was tested by conditional multiple logistic regression analysis. RESULTS: Compared with controls, @entity1 with @entity14 were less likely to have had an endoscopic procedure of the large bowel before being diagnosed with @entity5 (odds ratio for @entity694 , 0.51 [95% CI, 0.44 to 0.58]; odds ratio for @entity5 , 0.55 [CI, 0.47 to 0.64]). In @entity1 who had flexible sigmoidoscopy, colonoscopy, and polypectomy, the odds ratios were even smaller. When analyzed by separate 1-year intervals, @entity1 with @entity5 had significantly fewer procedures during periods of up to 6 years before their onset of their @entity5 . Similarly, fewer inpatient and outpatient procedures were done in @entity1 than in controls. CONCLUSIONS: Endoscopic procedures of the large bowel reduce the risk for developing @entity694 by 50%, their protective influence lasting 6 years.
