Urinary excretions of high molecular weight @entity4938 and albumin are independently associated with @entity301 in @entity1 , a nested case-control study of middle-aged XXXX in the Diagnostisch Onderzoek Mammacarcinoom (DOM) Cohort, Utrecht, Netherlands.

@entity1 @entity0 @entity6 @entity301 @entity583 @entity101 @entity1011 @entity453 @entity4938 @entity65
Increased plasma levels of @entity4938 , a platelet activation marker, are observed in @entity453 . Urinary albumin excretion, a marker of endothelial cell perturbation, is related to @entity65 in @entity6 . To test the value of these markers in predicting forthcoming @entity301 , the relations between urinary excretions of high molecular weight @entity4938 (HMW-beta TGf) and albumin and subsequent @entity301 in a cohort of 15,484 middle-aged @entity1 were investigated in a nested case-control study. Baseline questionnaire data and urine samples were available from a @entity0 screening program in Utrecht during 1982-1985. Cases were Utrecht hospital admissions for @entity583 (n = 50) or angiographically confirmed @entity301 (n = 28) from 1982-1985 to 1990-1991. Classifying events occurred a median of 5.1 years after baseline. Controls were a random sample from the cohort, individually case matched for baseline examination date and age, at a 1:2 ratio. HMW-beta TG/ @entity1011 ratios (ng/mmol, mean +/- standard error) were 5.3 +/- 0.3 in cases and 4.7 +/- 0.3 in controls; albumin/ @entity1011 ratios (mg/mmol, median) were, respectively, 0.37 and 0.22. Crude odds ratios for classification in the highest compared with the lowest tertiles of HMW-beta TG/ @entity1011 and albumin/ @entity1011 distributions were elevated for cases compared with controls: HMW-beta TG/ @entity1011 odds ratio = 2.4, 95% confidence interval 1.1-5.0; albumin/ @entity1011 odds ratio = 2.1, 95% confidence interval 1.0-4.1. These relations persisted after adjustment for smoking, @entity101 , Quetelet index, and menopausal status. Both urinary HMW-beta TG and albumin excretion are markers of @entity301 risk in middle-aged @entity1 , indicating that increased platelet activation and endothelial cell perturbation precede @entity301 events in @entity1 .
