Protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of XXXX .

@entity19 @entity5294 @entity2042 @entity19550
OBJECTIVE: To investigate the protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of @entity2042 in @entity19 . METHODS: An orthogonal table L(16) (4 x 2(12)) was selected as the experimental design. Eight-week-old Kunming outbred @entity19 (male and female) were randomly divided into 16 experimental groups and 2 control groups. Control groups were injected with @entity19550 ascites intraperitoneally. @entity19 from each group were infected with 100 +/- 2 cercariae of @entity2042 in the abdominal skin and were sacrificed on the thirtieth day postchallenge. @entity5294 were recovered and counted by perfusion of the left ventricle-portal vein. The @entity19550 ascites injected @entity19 were used as controls and the percentage of protection was calculated. RESULTS: Active immunization of @entity19 with NP30 could produce protection levels ranging from 22.36% to 50.46% depending on the different immunity protocols. The best immunization protocol was established from the results. CONCLUSIONS: Active immunization with NP30 can induce a degree of protection to infection with @entity2042 cercariae and NP30 is a potential vaccine candidate against @entity2042 .
