@entity1822 in a xenograft nude XXXX model using high-intensity focused ultrasound: a potential treatment modality for recurrent pelvic disease.

@entity19 @entity5 @entity1822 @entity3 @entity35
OBJECTIVE: The objective was to test the efficacy of high-intensity focused ultrasound (HIFU) for treatment of @entity1822 in a Xenograft nude @entity19 model. METHODS: A total of 65 athymic @entity19 were inoculated subcutaneously with 5 to 7 x 10(6) ELT-5B cells, a @entity1822 cell line derived from the Eker @entity35 . Thirty animals showed @entity5 growth. The @entity5 volume was measured transcutaneously once a week. Animals were randomly assigned to three groups: HIFU treatment (n = 17), sham treatment (n = 7), and control (n = 6). A HIFU device, operating at a frequency of 2.0 MHz and an intensity of 2000 W/cm(2), was used for treatment. RESULTS: Within 3 weeks of a single HIFU treatment, 100% reduction in @entity5 volume was observed in all animals, except one. A second HIFU treatment was applied to that animal, resulting in 100% reduction in @entity5 volume. The @entity5 in the sham-treated animals continued to grow at a similar rate to that of the control group to approximately 500% of the @entity5 volume at the time of treatment. All animals were monitored for a maximum of 3 months. No @entity3 was observed in the HIFU-treated animals. Histological examination confirmed a complete @entity5 disappearance after HIFU treatment. CONCLUSION: We have shown that HIFU can effectively treat @entity1822 tumors inoculated in Xenograft @entity19 , demonstrating HIFU's potential use for treatment of recurrent @entity1822 .
