Impact of XXXX use on urate concentration and cardiovascular outcome.

@entity1 @entity208
AIMS: To characterize @entity1 with urate measurements by urate-lowering therapy (ULT) use and to study the impact of @entity208 treatment on cardiovascular and mortality outcomes. METHODS: A cohort study using a record-linkage database. The study included 7135 @entity1 aged >= 60 years with urate measurements between 2000 and 2002 followed up until 2007. A Cox regression model was used. The association between urate levels, dispensed @entity208 and cardiovascular hospitalization and mortality was determined. RESULTS: Six thousand and forty-two @entity1 were not taking ULT and 45.9% of those (2774 of 6042) had urate concentrations  <=6 mg dl(-1) . Among 1035 @entity208 users, 44.7% (45.6% for @entity1 and 43.3% for @entity1 ) reached target urate concentration. There was no significant increased risk of cardiovascular events for @entity208 users when compared with non-ULT users [adjusted hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.95-1.26] and the non-ULT group with urate >6 mg dl(-1) (adjusted HR 1.07, 95% CI 0.89-1.28). Within the @entity208 use cohort, cardiovascular event rates were 74.0 (95% CI 61.9-86.1) per 1000 @entity1 years for the 100 mg group, 69.7 (49.6-89.8) for the 200 mg group and 47.6 (38.4-56.9) for the >= 300 mg group. Compared with low-dose (100 mg) users, high-dose (>= 300 mg) users had significant reductions in the risk of cardiovascular events (adjusted HR 0.69, 95% CI 0.50-0.94) and mortality (adjusted HR 0.75, 95% CI 0.59-0.94). CONCLUSIONS: Less than 50% of @entity1 taking @entity208 reached target urate concentration. Higher doses of @entity208 were associated with better control of urate and lower risks of both cardiovascular events and mortality.
