Preoperative nutritional status is an important predictor of survival in @entity1 undergoing surgery for XXXX .

@entity1 @entity417 @entity353 @entity5 @entity1358 @entity3147
BACKGROUND: The role of @entity3147 has not been well studied in @entity1 undergoing surgery for @entity1358 ( @entity1358 ). OBJECTIVE: Our aim was to evaluate whether @entity3147 ( @entity3147 ) is an important determinant of survival following surgery for @entity1358 . DESIGN, SETTING, AND @entity1 : A total of 369 consecutive @entity1 underwent surgery for locoregional @entity1358 from 2003 to 2008. @entity3147 was defined as meeting one of the following criteria: body mass index <18.5 kg/m(2), albumin <3.5 g/dl, or preoperative @entity353 >=  5% of body weight. INTERVENTION: All @entity1 underwent radical or partial nephrectomy. MEASUREMENTS: Primary outcomes were overall and disease-specific mortality. Covariates included age, Charlson comorbidity index (CCI), @entity417 , @entity5 stage, Fuhrman grade, and lymph node status. Multivariate analysis was performed using a Cox proportional hazards model. Mortality rates were estimated using the Kaplan-Meier product-limit method. RESULTS AND LIMITATIONS: Eighty-five @entity1 (23%) were categorized as @entity3147 . Three-year overall and disease-specific survival were 58.5% and 80.4% in the @entity3147 cohort compared with 85.4% and 94.7% in controls, respectively (p<0.001). @entity3147 remained a significant predictor of overall mortality (hazard ratio [HR]: 2.41, 95% confidence interval [CI], 1.40-4.18) and disease-specific mortality (HR: 2.76; 95% CI, 1.17-6.50) after correcting for age, CCI, @entity417 , stage, grade, and nodal status. This study is limited by its retrospective nature. CONCLUSIONS: @entity3147 is associated with higher mortality in @entity1 undergoing surgery for locoregional @entity1358 , independent of key clinical and pathologic factors. Given this mortality risk, it may be important to address nutritional status preoperatively and counsel @entity1 appropriately.
