Heterochromia after pediatric XXXX surgery.

@entity1 @entity231 @entity7462 @entity3774 @entity2608
PURPOSE: Changes in iris color have been noted anecdotally after @entity231 surgery in @entity1 , but they have not been studied systematically. The mechanism for these iris color changes has not previously been reported in the biomedical literature. METHODS: Photographs were taken of both eyes of 15 @entity1 and 11 @entity2608 who had undergone unilateral @entity231 surgery. Masked examiners reviewed the photographs and compared the iris color of the eyes that were operated on with the eyes that were not operated on. Between 4 and 6 weeks postoperatively, the level of @entity3774 in the @entity7462 (n = 4) and vitreous humor (n = 2) was measured in both the operated and nonoperated eyes of 4 monkeys that had undergone a neonatal lensectomy during the first 5 days of life. RESULTS: Thirteen of 15 @entity1 had a darker iris color in the operated eye in relation to the nonoperated (control) eye. Four of 11 monkeys had a uniformly darker iris in the operated eye; the other 7 monkeys had regional darkening or patches of darker iris in the eye that was operated on. The @entity3774 levels in neonatal monkeys were higher in the @entity7462 and in the vitreous humor of the operated eye in relation to the nonoperated eye. CONCLUSION: In some @entity1 , @entity231 surgery is associated with a darkening of the iris color in the operated eye. We speculate that this darkening results from an exuberant prostaglandin release stimulated by the @entity231 surgery and may occur through the same or a similar mechanism by which latanoprost causes the darkening of iris color.
