Shock wave therapy induces @entity2295 at the @entity79 . A study in XXXX .

@entity2295 @entity1711 @entity95 @entity79 @entity12914 @entity1710 @entity842 @entity94
Despite the success in clinical application, the exact mechanism of shock wave therapy remains unknown. We hypothesized that shock wave therapy induces the ingrowth of @entity2295 and improves blood supply to the tissues. The purpose of this study was to investigate the effect of shock wave therapy on @entity2295 at the @entity79 . Fifty New Zealand white @entity95 with body weight ranging from 2.5 to 3.5 kg were used in this study. The right limb (the study side) received shock wave therapy to the Achilles tendon near the insertion to bone. The left limb (the control side) received no shock wave therapy. Biopsies of the @entity79 were performed in 0, 1, 4, 8 and 12 weeks. The number of neo-vessels was examined microscopically with @entity1710 - @entity1711 stain. Neovascularization was confirmed by the angiogenic markers including vessel endothelial growth factor ( @entity94 ) and endothelial @entity842 synthase (eNOS) expressions and endothelial cell proliferation determined by @entity12914 ( @entity12914 ) expression examined microscopically with immunohistochemical stains. The results showed that shock wave therapy produced a significantly higher number of neo-vessels and angiogenesis-related markers including eNOS, @entity94 and @entity12914 than the control without shock wave treatment. The eNOS and @entity94 began to rise in as early as one week and remained high for 8 weeks, then declined at 12 weeks; whereas the increases of @entity12914 and neo-vessels began at 4 weeks and persisted for 12 weeks. In conclusion, shock wave therapy induces the ingrowth of @entity2295 associated with early release of angiogenesis-related markers at the Achilles @entity79 in @entity95 . The @entity2295 may play a role to improve blood supply and tissue regeneration at the @entity79 .
