Differential expression of XXXX , beta 3 and beta 4 integrins in @entity242 of the small, round, blue cell category.

@entity2828 @entity6012 @entity10483 @entity242 @entity5 @entity980
Integrins are a large and complex family of membrane spanning alpha beta heterodimeric cell surface glycoproteins mediating cell/cell and cell/matrix interactions. Small, round, blue cell @entity242 (SRBCS) are a group of poorly differentiated @entity5 of various and in part uncertain histogenesis displaying similar cytomorphology. Among them are @entity980 ( @entity980 ), @entity6012 [(G)NB], primitive peripheral @entity5 (pPNET) and @entity2828 ( @entity2828 ). Thirty-two SRBCS were studied immunohistochemically for the distribution of @entity10483 , beta 3 and beta 4 integrins in situ. We found complex and to some extent differential patterns of @entity10483 and beta 4 integrin subunit expression in different types of SRBCS: all of the @entity242 studied were consistently @entity10483 +, beta 4-, alpha 2-. Four of nine @entity980 were completely negative for all other integrin subunits studied while one @entity980 was alpha 5+ throughout and three @entity980 were focally alpha 5+. Three @entity980 expressed the alpha 6 and alpha v chains. In contrast to @entity980 , pPNET and @entity2828 , all of which were alpha 1-, alpha 3-, (G)NB were alpha 3+ and frequently co-expressed alpha 1. The eight pPNET and seven @entity2828 studied showed a similarly restricted integrin profile that was limited to the expression of @entity10483 in nearly all cases. In summary, @entity980 were @entity10483 +, alpha 1-, alpha 3- and heterogeneously expressed alpha 5 and alpha 6. (G)NB were generally @entity10483 +, alpha 1+, alpha 3+, alpha 5-, alpha 6-. pPNET and @entity2828 were @entity10483 +, alpha 1-, alpha 3-, alpha 5+, alpha 6-. The data illustrate a complex expression pattern of various integrins in SRBCS, a differential expression pattern of some of the integrin subunits among different types of SRBCS and almost identical integrin profiles in pPNET and @entity2828 .
