Oral brush biopsy and XXXX -associated antigens A (MAGE-A) staining in clinically suspicious lesions.

@entity5 @entity957 @entity189 @entity12120 @entity320
PURPOSE: In @entity5 and in other @entity5 entities, @entity320 -associated antigens are present. These antigens contribute to @entity5 progression and poor prognosis, and reduce the cytotoxicity of antineoplastic drugs. The aim of this study was to investigate the diagnostic potential of these antigens in combination with oral brush biopsies. MATERIAL AND METHODS: We analyzed 72 oral brush biopsy specimens for @entity320 -associated antigens A (MAGE-A) expression by immunocytologic staining with the MAGE-A 57B antibody. A total of 24 healthy specimens, 15 lichen ruber cases, 18 @entity12120 cases, and 15 invasive @entity189 were studied. Incisional biopsy served as the gold standard. RESULTS: In total, 66 of 72 specimens (91.6%) could be assessed. Twelve of 15 (80%) @entity189 stained positive for MAGE-A. MAGE-A staining was detected in four of 51 nonmalignant specimens, resulting in a false-positive rate of 7.8%. However, MAGE-A  positive staining was significantly correlated with @entity957 (p  <  0.0005). Sensitivity and specificity for MAGE-A staining and @entity189 were 80% and 92.2%, respectively. The diagnostic accuracy was 89.4%. CONCLUSION: Our results indicate that oral brush biopsy with MAGE-A staining serves as an additional tool for use in @entity5 diagnosis. These findings might help to facilitate an easier and more representative surveillance of the mucosa, particularly for large areas of altered mucosa.
