The toxic effects of XXXX nanoparticles on blood mononuclear cells.

@entity1 @entity98 @entity137 @entity575
BACKGROUND: Nanoparticles have become one of the leading technologies over the past two years. The extensive use of nanoparticles has raised great concern about their occupational fate and biological effects. With an increase in the production and use of nanomaterial, it is more likely to get exposed to them occupationally and environmentally. OBJECTIVE: To assess the @entity137 of @entity575 nanoparticles on @entity1 mononuclear cells. METHODS: In this in vitro experimental study, suspensions of blood mononuclear cells from 10 young healthy @entity1 were incubated with 10-nm @entity575 nanoparticles in different concentrations (range: 1-500  g/mL) for 6 and 24 hours by @entity98 assay. Positive and negative controls were used for comparison. RESULTS: After 6 hours of exposure, 10.9% to 48.4% of the cells died. After 24 hours of exposure, the rate ranged from 56.8% to 86.3%. Regardless of the exposure time, the maximum @entity137 was observed at the concentration of 500  g/mL of @entity575 nanoparticles. By increasing the exposure time to 24 hours, the @entity137 of nanoparticles substantially increased at all concentrations. Cell death was significantly higher when compared to the controls (p<0.01). CONCLUSION: @entity575 nanoparticles possess both time- and dose-dependent @entity137 and can thus be considered as very toxic for mononuclear cells.
