Combined chemotherapy, radiation, and surgery for epithelial XXXX of the anal canal.

@entity1 @entity137 @entity5 @entity1138 @entity177 @entity1487
Combined chemotherapy and radiation therapy have been reported to produce a high incidence of complete regression of epithelial @entity5 of the anal canal, resulting in prolonged disease-free survival. This modality has been advocated as an alternative to abdominoperineal resection as a primary treatment for this disease. Our group treated 19 @entity1 between 1979 and 1985. Treatment included two infusions of @entity1487 (1000 mg/m2/24 hours), one dose of @entity1138 (15 mg/m2), and simultaneous whole-pelvis radiation (3000 rad). The complete response rate was 88%. Three @entity1 had @entity5 incompletely controlled by that therapy. They underwent abdominoperineal resections and are alive without disease at 10, 39, and 43 months, respectively. Actuarial disease-free survival at 40 months was 87.5 +/- 8.8 (% +/- standard error of the mean [SEM]). Complications included gastrointestinal, hematologic, and cutaneous @entity137 . These results confirmed a high complete response rate to this therapy. @entity177 may occur, but these may be salvaged with abdominoperineal resection.
