XXXX is a central component in neuropeptide regulation of appetite.

@entity32327 @entity19 @entity20649 @entity842 @entity20648
In recent years, there have been a large number of neuropeptides discovered that regulate food intake. Many of these peptides regulate food intake by increasing or decreasing @entity842 (NO). In the current study, we compared the effect of the food modulators @entity20649 , @entity32327 and @entity20648 in NOS KO @entity19 . Satiated homozygous and heterozygous NOS KO @entity19 and their wild type controls were administered @entity20649 ICV. Food intake was measured for 2h post injection. @entity20649 did not increase food intake in the homozygous NOS KO @entity19 compared to vehicle treated NOS KO @entity19 , whereas food intake was increased in the wild type controls compared to vehicle treated wild type controls. @entity32327 was administered ICV and food intake measured for 2h. Homozygous NOS KO @entity19 showed no increase in food intake after @entity32327 administration, whereas the wild type controls did. In our final study, we administered @entity20648 intraperitoneally to homozygous and heterozygous NOS KO @entity19 and their wild type controls after overnight food deprivation. Food intake was measured for 1h after injection. @entity20648 inhibited food intake in wild type @entity19 after overnight food deprivation, however, @entity20648 failed to inhibit food intake in the NOS KO @entity19 . The heterozygous @entity19 showed partial food inhibition after the @entity20648 . The current results add further support to the theory that NO is a central mediator in food intake.
