Budding as a useful prognostic marker in @entity1803 well- or moderately-differentiated XXXX .

@entity1 @entity1803 @entity1711 @entity189 @entity1710 @entity14 @entity3 @entity420
BACKGROUND: Budding along the invasive margin is reported to be associated with greater malignant potential in @entity14 . We examined the prognostic significance of budding in @entity1 with @entity1803 @entity189 , particularly in comparison to other routine pathological findings. METHODS: Surgically resected specimens from 83 well- or moderately-differentiated @entity1803 @entity420 were studied. All resections were curative (R0), and the median postoperative follow-up was 47 months. We examined the presence of budding according to Morodomi's criteria, using @entity1710 - @entity1711 stained sections. RESULTS: Budding was found in 48 @entity1 (57.9%). The incidence of budding was significantly higher in lesions displaying lymphatic invasion and lymph-node @entity3 than in those without (P < 0.0001). Both local recurrence and liver @entity3 were more frequent in @entity1 with budding-positive lesions (P < 0.002 and 0.02, respectively). Moreover, postoperative survival was significantly decreased in @entity1 with budding-positive lesions than in those with budding-negative lesions (cumulative 5-year survival rate were 51.8 and 85.0%, respectively: P < 0.002). Multivariate proportional hazard model revealed that the presence of budding was the only significant co-factor of postoperative survival. CONCLUSIONS: Budding is a pathological marker suggesting high malignant potential and decreased postoperative survival in @entity1 with well- or moderately-differentiated @entity1803 @entity420 .
