Optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy in retinal nerve fiber layer measurements of XXXX @entity1 .

@entity1 @entity1538 @entity6653 @entity726 @entity9999 @entity12447
PURPOSE: To determine the correlations and strength of association between different imaging systems in analyzing the retinal nerve fiber layer (RNFL) of @entity726 @entity1 : optical coherence tomography ( @entity6653 ), scanning laser polarimetry (SLP) and confocal scanning laser ophthalmoscopy (CSLO). MATERIALS AND METHODOLOGY: 114 eyes of @entity1 with moderate @entity1538 underwent spectral domain @entity6653 (Topcon SD- @entity6653 2000 and Zeiss Cirrus HD- @entity6653 ), SLP ( @entity9999 Pro) and CSLO (Heidelberg Retina Tomograph, @entity12447 ). Correlation coefficients were calculated between the structural parameters yielded by these examinations. The quantitative relationship between the measured RNFL thickness globally and for the four regions (superior, inferior, nasal, temporal) were evaluated with different regression models for all used imaging systems. RESULTS: The strongest correlation of RNFL measurements was found between devices using the same technology like @entity9999 VCC and @entity9999 Pro as well as Topcon @entity6653 and Cirrus @entity6653 . In @entity726 @entity1 , the strongest associations (R  ) were found between RNFL measurements of the two optical coherence tomography devices Topcon @entity6653 and Cirrus @entity6653 (R   = 0.513) and between @entity9999 VCC and @entity9999 Pro (R   = 0.451). The results of the OCTs and @entity9999 Pro also had a strong quantitative relationship (Topcon @entity6653 R   = 0.339 and Cirrus @entity6653 R   = 0.347). @entity9999 VCC and the OCTs showed a mild to moderate association (Topcon @entity6653 R   = 0.207 and Cirrus @entity6653 R   = 0.258). The confocal scanning laser ophthalmoscopy ( @entity12447 ) had the lowest association to all other devices (Topcon @entity6653 R   = 0.254, Cirrus @entity6653 R   = 0.158, @entity9999 Pro R   = 0.086 and @entity9999 VCC R   = 0.1). CONCLUSION: The measurements of the RNFL in @entity726 @entity1 reveal a high correlation of @entity6653 and @entity9999 devices because OCTs can measure all major retinal layers and SLP can detect nerve fibers allowing a comparison between the results of this devices. However, CSLO by means of HRT topography can only measure height values of the retinal surface but it cannot distinguish between different retinal layers. This may explain the rather poor correlations and associations between CSLO measurements and those of all other imaging devices which makes it difficult to compare @entity12447 nerve fiber data. These correlations are important in clinical routine especially when different techniques are used in the follow-up of @entity726 @entity1 .
