Cross sectional study to investigate the influence of treatment regimes on the development of XXXX .

@entity1 @entity447 @entity73 @entity1373 @entity603 @entity79 @entity2720 @entity85 @entity68
@entity2720 is often present in @entity1 with severe @entity447 . New studies demonstrate that only a small amount and a short exposure of blood in vitro are able to induce an @entity73 . Free blood in the joint leads to different mechanisms and includes cartilage and @entity79 induced by a release of macrophages and monocytes followed by activated cytokines and inflammatory processes. Another mechanism is mediated by free @entity68 resulting in @entity603 and @entity1373 and a neoangiogenesis on the base of VEGF release is common. At worst, these processes result in a complete picture of @entity2720 reducing quality of life. Few studies are available about the influence of factor treatment regime, e. g. prophylaxis or on-demand therapy, on the development of @entity2720 . However these studies investigated in most cases @entity1 . Therefore, it is still impossible to give recommendations for the right treatment in adult haemophilic @entity1 because data are still lacking. For that reason, we attempt to initiate the HemArthro-Project to investigate the influence of treatment therapy on the development of @entity2720 in adult haemophilic @entity1 . This study includes the @entity85 for the description of joint function in maximal 500 severe haemophilic @entity1 parted into two groups of treatment regime (prophylaxis vs. on-demand). The investigators are seeking further assistance from the haemophilic treatment centers for the support of this study.
