Chemotherapy-induced XXXX in daily clinical practice: a community hospital-based study.

@entity1 @entity390 @entity4349 @entity5 @entity391 @entity1209
BACKGROUND: Chemotherapy-induced @entity1209 (CINV) are major adverse effects of @entity5 chemotherapy. This study investigated: (1) the impact of CINV on @entity1 ' health-related quality of life (HRQL) in daily clinical practice; (2) the association between @entity1 characteristics and type of antiemetics and CINV; and (3) the role of CINV in physicians' decisions to modify antiemetic treatment. @entity1 AND METHODS: This prospective, multicenter study was conducted in nine general hospitals in the Netherlands. During three consecutive chemotherapy cycles, @entity1 used a diary to record episodes of @entity390 , @entity391 and antiemetic use. For each cycle, these ratings were made 1 day prior to and 7 days after having received chemotherapy. The influence of CINV on @entity1 ' HRQL was evaluated with the Functional Living Index-Emesis (FLIE) questionnaire at day 6 of each treatment cycle. (Changes in) antiemetic use were recorded by the treating nurse. @entity1 inclusion took place between May 2005 and May 2007. RESULTS: Two hundred seventy-seven @entity1 were enrolled in the study. Acute and delayed @entity390 during the first treatment cycle was reported by 39% and 68% of the @entity1 , respectively. The comparable figures for @entity391 were 12% and 23%. During the first and subsequent treatment cycle, approximately one-third of the @entity1 indicated that CINV had a substantial impact on their daily lives. Female @entity1 and younger @entity1 reported significantly more CINV than male and older @entity1 . At all treatment cycles, @entity1 receiving treatment with moderately emetogenic chemotherapy, containing @entity4349 , reported more acute @entity390 than @entity1 receiving highly emetogenic chemotherapy. Acute @entity391 was associated significantly with change in (i.e., additional) antiemetic treatment. Delayed CINV did not influence antiemetic treatment. CONCLUSION: CINV continues to be a problem that adversely affects the daily lives of @entity1 . CINV is worse in @entity1 and in younger @entity1 . In daily clinical practice, acute CINV, but not delayed CINV, results in changes in antiemetic treatment. In view of the effects of not only acute, but also delayed CINV on daily life, more attention should be paid to adjustment of antiemetic treatment to cover CINV complaints, later during the chemotherapy cycle.
