Treatment of @entity1 XXXX xenografts using natural interferons-alpha and -gamma injected singly or in combination.

@entity1 @entity18176 @entity0 @entity19 @entity5
Natural interferons (nIFNs) -alpha and -gamma were used to treat @entity19 bearing bilateral xenografts of @entity1 @entity0 cells (MCF-7 and @entity18176 ). The IFNs were administered singly or in combination by means of intralesional (i.l.) or intraperitoneal (i.p.) injections. In the animals treated intralesionally 1 of the 2 @entity5 was injected to study the local therapeutic effects, while the contralateral one was left undisturbed and used to assess systemic effects. Treatment of @entity5 with i.l. injections of nIFN-alpha and nIFN-gamma combined resulted in complete regression of the injected @entity5 in 8 of 20 @entity19 treated for 2 weeks and in 10 of 10 @entity19 of an additional group treated for 4 weeks. The corresponding contralateral @entity5 showed complete regression in 2 @entity19 treated for 4 weeks and partial responses in the others. Incomplete responses were also observed when the IFNs were used singly or when they were delivered intraperitoneally. Similarly, in @entity18176 xenografts the best results were obtained with i.l. injections of the 2 IFNs combined, but no complete regressions were achieved. These experiments provide further evidence for a synergistic interaction of nIFN-alpha and nIFN-gamma in vivo and indicate that the potentiated antitumoral activity is greater when these interferons are administered i.l.
