@entity3558 gene expression in intraductal papillary-mucinous @entity5 and XXXX .

@entity652 @entity4929 @entity3079 @entity1124 @entity5090 @entity5 @entity75 @entity1373 @entity5091 @entity26484 @entity5089 @entity3558 @entity5087 @entity2355 @entity21826 @entity5088 @entity420 @entity1141 @entity2513
Intraductal @entity5 (IPMTs) of the pancreas are heterogeneous proliferations characterized by a malignant potential. The molecular mechanisms underlying the tumourigenesis process are not well understood. Recently, it has been shown that IPMTs secreting the @entity3558 antigen @entity5091 have a better prognosis, but the complete pattern of MUC gene expression has not yet been established. The aims of this study were to evaluate the @entity3558 gene expression in 57 IPMTs and eight @entity75 surgically resected and to relate MUC gene expression to the histological diagnosis. In situ hybridization (ISH) was performed in 28 cases with probes specific for the @entity2355 , @entity5091 , @entity5087 , @entity5088 , @entity5089 , @entity5090 , @entity21826 , and @entity26484 genes. An immunohistochemical analysis was carried in all 65 cases and in 90 @entity420 of the pancreas using @entity2355 , @entity5091 , and @entity5089 antibodies. IPMTs of @entity652 ( @entity1141 ) type exhibited high expression of @entity5091 (93%), @entity5089 (97%), and, to a lesser extent, of @entity5088 (71%), all of which were also observed in @entity3079 associated with IPMTs. In contrast, IPMTs with simple @entity1373 , @entity4929 , and @entity652 exhibited little or no expression of @entity5091 . The @entity3558 expression profile supports the existence of two types of invasive @entity5 associated with IPMTs: a colloid and an ordinary form. The latter shows a pattern similar to the @entity420 with a loss of @entity5091 and a gain of @entity2355 and has a greater tendency to metastasize. In conclusion, the altered expression of @entity3558 , characteristic of IPMT of @entity2513 , may contribute to the better clinical outcome of these @entity5 , compared to conventional @entity1124 .
