The consequences of eccentric contractions and their relationship to delayed onset XXXX .

@entity32 @entity925 @entity158
Exercise can cause @entity925 for a number of reasons. Usually the @entity158 is experienced during the exercise and recovers rapidly afterwards. There is one type of @entity925 that has a very different and characteristic time course. In this situation the exercise itself, and the immediate post-exercise period are painfree. The @entity158 is not felt for about eight hours and is maximal 1 or 2 days later. Delayed onset @entity925 occurs after unaccustomed, high force contractions and is particularly associated with eccentric contractions. The concensus of opinion is that the @entity158 is caused by some form of damage, but the mechanism for the @entity158 is not known. This review summarises the literature on the consequences of eccentric contractions and relates them to delayed onset @entity925 . There is clear evidence of damage to the muscle fibres themselves, their membranes and, at a later stage, mononuclear cell infiltration, but all these have very different time courses and none are the same as the @entity158 . Intramuscular pressures are raised in some, but not all, painful compartments and even when raised follow a different time course to the @entity158 . Anti-inflammatory agents do not affect the @entity158 , but due to the incomplete understanding of the action of these drugs, the role of @entity32 in delayed onset @entity925 is uncertain. Despite the considerable evidence of damage after eccentric contractions, the cause of delayed onset @entity925 is still unknown.
