Determinants of high-grade dysplasia among XXXX with mild dyskaryosis on cervical smear.

@entity1 @entity3146
OBJECTIVE: To identify the epidemiologic characteristics of @entity1 who have mild dyskaryosis on cervical smear but @entity3146 ( @entity3146 ) grade II or III at biopsy. METHODS: We analyzed information from 291 @entity1 (median age 33 years, range 17-69) observed for the first time with a single smear test showing mild dyskaryosis. All subjects underwent colposcopy, and histologic confirmation was obtained by biopsy. We compared the characteristics of @entity1 who had @entity3146 I or no evidence of @entity3146 with those of @entity1 with @entity3146 or III at biopsy. RESULTS: Twenty-eight @entity1 (10%) had @entity3146 I at biopsy, 46 (15%) @entity3146 , and 23 (8%) @entity3146 . The frequency of @entity3146 or III tended to decrease with increasing education; compared with @entity1 reporting 11 or fewer years of education, the multivariate odds ratios (OR) of @entity3146 was 0.5 (95% confidence interval [CI] 0.3-0.9) in those reporting 11 years of education or more. Compared with nulliparas, the OR of @entity3146 or III was 1.8 (95% CI 1.1-3.5) for parous @entity1 . Furthermore, compared with never-smokers, the OR of @entity3146 or III was 2.3 (95% CI 1.0-5.4) for current smokers. Ex-smokers were at increased risk, too; the estimated multivariate OR was 3.8 (95% CI 1.9-7.6). Compared with @entity1 reporting one sexual partner, the multivariate ORs of @entity3146 or III were 1.4 and 2.3 for @entity1 reporting two to three or four or more sexual partners, respectively (chi 2(1) trend = 6.65, P < .05). CONCLUSION: Our results show that smoking is a risk indicator of @entity3146 or III in @entity1 with a single smear showing mild dyskaryosis. Parous @entity1 , those of low social standing, and those reporting multiple sexual partners also are at increased risk of @entity3146 or III.
