Memory function in a @entity19 genetic model of XXXX .

@entity6970 @entity19 @entity73 @entity195 @entity2414
The E4 allele of the @entity6970 ( @entity6970 ) gene has been identified as a major risk factor for the development of late onset @entity195 ( @entity195 ). However, the mechanisms by which this gene affects @entity195 are not fully understood. Studies of @entity6970 knock-out ( @entity6970 KO) @entity19 have revealed an exacerbation of two major pathologies that are diagnostic of @entity195 : neurofibrillary tangles and senile plaques. However, evidence as to whether these @entity19 have @entity73 is not yet conclusive. This ambiguity may arise partly from confounds associated with reliance on limited memory models, primarily, the Morris water maze task. An 8-arm radial maze task was therefore used to measure spatial memory in the @entity6970 KO @entity19 , compared to controls over time. Furthermore, the effectiveness of a combination antioxidant therapy (CAT), designed to slow down the progression of @entity195 based on concepts of oxidative stress and inflammatory processes underlying the pathology, was tested on memory ability. A significant strain difference was observed with the @entity6970 KO @entity19 performing better than controls in terms of reference memory and corrects entries. No significant strain difference was observed for performance in terms of working @entity2414 . No significant effect of the CAT supplementation was observed.
