Synthetic polymer as an adjuvant in collagen-induced XXXX .

@entity1 @entity137 @entity625 @entity19 @entity1753 @entity166 @entity1683 @entity792 @entity309
@entity1753 ( @entity1753 ), the classical animal model for experimental @entity625 , resembles @entity1 @entity309 in several aspects. However, the most widely used method of inducing @entity1753 utilizes Freund's adjuvants, which can skew the elicited immune responses and also pose @entity137 problems. This unit describes a new method of inducing @entity1753 using a well defined stimuli-responsive synthetic polymer, @entity1683 -based adjuvant, mixed with the joint cartilage protein collagen type II (CII). @entity1683 as an adjuvant is biodegradable and biocompatible, and does not skew immune responses. Thus, it is helpful in the development of @entity625 models for studying antigen and tissue -specific autoimmune responses in an unbiased manner. This model is valuable for analyzing disease pathways, positional identification of genes regulating @entity625 , validation of existing therapies, and exploring new therapeutic targets. Furthermore, this newly developed @entity1683 adjuvant allows investigation of disease induction using specific autoantigens in several @entity792 independently of toll-like receptors, as well as optimization of vaccine delivery systems for @entity166 . Curr. Protoc. @entity19 Biol. 4:11-24    2014 by John Wiley _ Sons, Inc.
