Essential XXXX is associated with disruption of functional connectivity in the ventral intermediate Nucleus-Motor Cortex-Cerebellum circuit.

@entity1 @entity400 @entity2277
UNASSIGNED: The clinical benefits of targeting the ventral intermediate nucleus ( @entity2277 ) for the treatment of @entity400 in essential @entity400 (ET) @entity1 suggest that the @entity2277 is a key hub in the network of @entity400 generation and propagation and that the @entity2277 can be considered as a seed region to study the @entity400 network. However, little is known about the central @entity400 network in ET @entity1 . Twenty-six ET @entity1 and 26 matched healthy controls (HCs) were included in this study. After considering structural and head-motion factors and establishing the accuracy of our seed region, a @entity2277 seed-based functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging (RS-fMRI) data was performed to characterize the @entity2277 FC network in ET @entity1 . We found that ET @entity1 and HCs shared a similar @entity2277 FC network that was generally consistent with the @entity2277 anatomical connectivity network inferred from normal nonhuman primates and healthy @entity1 . Compared with HCs, ET @entity1 displayed @entity2277 -related FC changes, primarily within the @entity2277 -motor cortex (MC)-cerebellum (CBLM) circuit, which included decreased FC in the CBLM and increased FC in the MC. Importantly, @entity400 severity correlated with these FC changes. These findings provide the first evidence that the pathological @entity400 observed in ET @entity1 might be based on a physiologically pre-existing @entity2277 - MC - CBLM network and that disruption of FC in this physiological network is associated with ET. Further, these findings demonstrate a potential approach for elucidating the neural network mechanisms underlying this disease. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.
