Comparison of Speed of Sound Measures Assessed by Multisite Quantitative Ultrasound to Bone Mineral Density Measures Assessed by Dual-Energy X-Ray Absorptiometry in a Large Canadian Cohort: the Canadian Multicentre XXXX Study (CaMos).

@entity1 @entity79 @entity170 @entity174
UNASSIGNED: Dual-energy X-ray absorptiometry (DXA) is an important tool for the estimate of @entity174 risk through the measurement of @entity79 ( @entity79 ). Similarly, multisite quantitate ultrasound can prospectively predict future @entity174 through the measurement of speed of sound (SOS). This investigation compared @entity79 (at the femoral neck, total hip, and lumbar spine) and SOS measures (at the distal radius, tibia, and phalanx sites) in a large sample of randomly-selected and community-based individuals from the Canadian Multicentre @entity170 Study. Furthermore, mass, height, and age were also compared with both measures. There were 4123 @entity1 included with an age range of 30-96.8  yr. Pearson product moment correlations between @entity79 and SOS measures were low (0.21-0.29; all p  <  0.001), irrespective of site. Mass was moderately correlated with @entity79 measures (0.40-0.58; p  <  0.001), but lowly correlated with SOS measures (0.03-0.13; p  <  0.05). @entity79 and SOS were negatively correlated to age (-0.17 to -0.44; p  <  0.001). When regression analyses were performed to predict SOS measures at the 3 sites, the models predicted 20%-23% of the variance, leaving 77%-80% unaccounted for. The SOS measures in this study were found to be largely independent from @entity79 measures. In areas with no or limited access to DXA, the multisite quantitative ultrasound may act as a valuable tool to assess @entity174 risk. In locales with liberal access to DXA, the addition of SOS to @entity79 and other clinical risk factors may improve the identification of those @entity1 at high risk for future @entity174 .
