Comparing the efficacy of stimulants for @entity71 in XXXX and adolescents using meta-analysis.

@entity1 @entity4944 @entity71 @entity2727
Stimulants used to treat @entity71 ( @entity71 ) have been well researched, but comparisons among stimulants are hindered by the absence of direct comparative trials. The goal of this work was to compare the efficacy of @entity2727 and @entity4944 formulations through a meta-analysis of double-blind placebo-controlled trials. We analyzed recent published literature on the stimulant therapy of @entity71 to describe the variability of drug-placebo effect sizes. A literature search was conducted to identify double-blind, placebo-controlled studies of @entity71 in @entity1 and adolescents published after 1979. Meta-analysis regression assessed the influence of medication type and study design features on medication effects. Twenty-three trials met criteria and were included in this meta-analysis. These trials studied 11 drugs using 19 different outcome measures of hyperactive, inattentive, or impulsive behavior. We found significant differences between @entity4944 and @entity2727 products, even after correcting for study design features that might have confounded the results. Our analyses indicate that effect sizes for @entity4944 products are significantly, albeit moderately, greater than those for @entity2727 . We found that most measures of effect from all studies were statistically significant. Our findings suggest that @entity4944 products may be moderately more efficacious than @entity2727 products, even after controlling for potentially confounding study design features. This difference in effect size may be due to differences between @entity4944 and @entity2727 in the molecular mechanisms involved in facilitating the dopaminergic neurotransmission.
