Impact of prior biopsy scheme on pathologic features of XXXX detected on repeat biopsies.

@entity5 @entity1
The object of our study was to characterize the biopsy features of @entity5 detected in a repeat biopsy population stratified on the basis of the type of prior negative biopsy. We studied 218 @entity1 with a prior negative biopsy who underwent a 10-core extended systematic biopsy scheme, and a subset (n = 139) underwent additional 6 anteriorly directed biopsies. Clinicopathologic features of @entity1 with @entity5 on the biopsy were compared as a function of type of prior negative biopsy. Overall and unique @entity5 detection rates were calculated for each of the biopsy sites. @entity5 detection rates tended to be higher in @entity1 who had undergone a prior sextant biopsy compared to a prior extended biopsy scheme (39% vs. 28%). Trends towards more positive cores and greater total core length of @entity5 involvement were seen in @entity1 who had undergone a prior negative sextant biopsy. Apical and laterally directed biopsies had higher overall and unique @entity5 detection rates in @entity1 who had undergone a prior negative sextant biopsy. Anteriorly directed biopsies had a low unique @entity5 detection rate in all @entity1 . We conclude that in @entity1 undergoing repeat biopsy, the detection rate is affected by the extent of the prior biopsy. Clinicopathologic features of @entity5 detected on repeat biopsy tend to be worse in @entity1 who have undergone a prior negative sextant biopsy compared to a negative prior extended biopsy.
