Facile synthesis of @entity1499 intercalated layered double XXXX : Particle control, structure and bioassay explore.

@entity6445 @entity15680 @entity5 @entity1500 @entity2195 @entity1499 @entity968
To study the influence of particle size on drug efficacy and other properties, a series of @entity1499 intercalated layered double @entity15680 ( @entity1500 /LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and @entity968 ( @entity968 ) as the solvent. To adjust the particle size of @entity1500 /LDHs, the dropping way, the volume ratio of water to @entity968 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140nm. @entity2195 and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids. X-ray diffraction (XRD) patterns manifested the successful intercalation of @entity1500 anions into the LDH interlayers, and it's also found out that different volume ratios of water to @entity968 and variable dropping way can affect the crystallinity of the final samples, i.e., the volume ratio of 3:1 and pH decreasing are proved to be optimum conditions. Furthermore, both antiparallel monolayer and bilayers adopting different orientations are suggested for four samples from XRD results. Fourier transform infrared spectroscopy (FTIR) investigations proved the coexistence of @entity6445 and @entity1500 anions in the interlayer of the nanohybrids. @entity1500 /LDH particles exhibited hexagonal platelet morphology with round corner and different dropping ways can affect the morphology greatly. Moreover, a DSC study indicated that longer time treatment can weaken the bond between the @entity1500 anions and LDH layers. The kinetic release profiles told us that larger @entity1500 /LDH particles have enhanced the ability of LDH layers to protect interlayer molecules. At last, the bioassay study indicated that the nanohybrids with larger diameters have higher @entity5 suppression efficiency.
