Evidence that XXXX does not inhibit allograft rejection by @entity2047 -treated sensitized splenocytes.

@entity19 @entity205 @entity2047 @entity870
Splenocytes sensitized in vitro to the H-2 allotype of a skin allograft have been shown to cause accelerated rejection of the skin allograft after adoptive transfer of the splenocytes. Treatment of the host with splenectomy or sublethal radiation did not alter the accelerated rejection. In the present study, @entity205 ( @entity870 ) given subcutaneously to @entity19 bearing 1 day old skin grafts prevented the rejection of the graft despite the adoptive transfer of sensitized cells. If the @entity870 was given for 14 days at 50 mg/kg every other day, the grafts were rejected an average of 6 days after the cessation of @entity870 . If the @entity870 was given for 20 days 50 mg/kg every other day, the grafts were not rejected even after cessation of @entity870 . When no sensitized cells were given, the same pattern resulted; that is, when a 14 day course of @entity870 was given the grafts were rejected after cessation of the @entity870 but when a 20-d course was given, the grafts were not rejected even after the @entity870 was stopped. If splenocytes were sensitized in the presence of @entity2047 ( @entity2047 ), they caused rejection of the skin allografts in animals even on treatment with @entity870 . We concluded that @entity870 can prevent skin allograft rejections in the @entity19 system. Moreover, the dose of @entity870 was critical, in that a longer course of @entity870 was necessary for tolerance. @entity870 further prevented the accelerated rejection of skin allografts by adoptive transfer of specifically sensitized splenocytes. Donor irradiation did not alter the effect of the @entity870 or of the adoptively transferred cells. @entity870 could not prevent the rejection of skin allografts when the adoptively transferred cells were sensitized to antigen in the presence of @entity2047 .
