Neuropathology of early and late deaths after XXXX .

@entity1 @entity1545 @entity39 @entity75 @entity4 @entity542 @entity772 @entity1410 @entity130
A previous study indicated that the mortality rate after severe @entity542 (Glasgow @entity772 score less than or equal to 7) was higher on each of the first 2 days after @entity130 (early deaths) than on any subsequent day (late deaths). The low Glasgow @entity772 scores, high incidence of unreactive pupils, and refractoriness to treatment of @entity1 dying within 48 hours of @entity130 suggested that many such @entity1 had sustained irreversible @entity1545 . To determine the extent to which events at impact sealed the fate of those dying early deaths after @entity542 , we compared the pathology of cases of early and late death. Of 2000 @entity1 with @entity542 admitted to the neurosurgery service during a 6-year period, there were 138 deaths and 56 autopsies. Seventy-two per cent of the @entity1 who died during the first 48 hours after @entity130 had widespread homogenizing @entity39 of neuron or direct brain stem @entity130 , considered to represent irreversible @entity75 . Only 19% of those dying later deaths had these pathological changes. @entity1 with severe homogenizing @entity39 or direct brain stem damage were usually injured in high speed motor vehicle accidents and had low Glasgow @entity772 scores and unreactive pupils on admission to the hospital. They usually did not have @entity1410 , but had @entity4 . @entity1 dying without homogenizing @entity39 or direct brain stem @entity130 usually were injured by blows or falls, usually had @entity1410 , and less often had unreactive pupils and low Glasgow @entity772 scores on admission. The findings suggest that there is a significant irreducible mortality rate after @entity542 incurred in high speed motor vehicle accidents. Recognition of such cases is important in the comparison of series and in the evaluation of treatment for @entity542 .
