Conformational change in coronary artery structure assessed by optical coherence tomography in @entity1 with XXXX .

@entity1 @entity12118 @entity75 @entity3361 @entity951 @entity2473 @entity741 @entity2553
OBJECTIVES: The aim of this study was to investigate the conformational change of arterial structure in the @entity75 with optical coherence tomography. BACKGROUND: @entity3361 plays an important role in the pathogenesis of @entity741 . The conformational change of each arterial layer during @entity2553 has not been studied in detail. METHODS: We assessed 19 coronary arteries (10 @entity2473 and 9 nonspasm lesions) with optical coherence tomography during the provocation test for @entity3361 . An intimal bump was defined as 1 or more intimal projections into the lumen that disappeared after the administration of @entity12118 (NTG). Intimal gathering was defined as a folding/gathering of the intima, resulting in multiple kinks in the luminal contour that resolved after the administration of NTG. RESULTS: The @entity2473 more frequently showed an intimal bump at baseline and intimal gathering during @entity2473 compared with the @entity75 ( @entity2473 80% vs. nonspasm 0%, p < 0.01, @entity2473 100% vs. nonspasm 0%, p < 0.01, respectively). The @entity2473 demonstrated a thicker maximum media thickness ( @entity2473 0.24    0.04 mm vs. nonspasm 0.12    0.03 mm, p < 0.01) at baseline, whereas no differences were observed after the administration of NTG ( @entity2473 0.13    0.03 mm vs. nonspasm 0.13    0.02 mm, p = 0.65). CONCLUSIONS: Our results suggest that medial contraction occurs even in an asymptomatic state and facilitates the formation of an intimal bump in @entity1 with @entity951 . Luminal narrowing during @entity2473 is associated with intimal gathering without alteration of intimal area.
