Metabolic markers of XXXX and cognitive function in normal older adults.

@entity1 @entity1501 @entity1255 @entity65361 @entity303 @entity2186 @entity15744 @entity12320
OBJECTIVES: To investigate the relationship between metabolic markers of @entity12320 and cognitive function in normal older adults. DESIGN: Cross-sectional study. SETTING: Queen's University and St. Mary's of the Lake Hospital, Kingston, Ontario, Canada. @entity1 : Two hundred eighty-one cognitively normal, community-dwelling @entity1 aged 65 and older. MEASUREMENTS: Serum cobalamin, red blood cell @entity1501 , @entity65361 , @entity1255 , and @entity15744 were determined. Cognitive instruments included the California Verbal Learning Test, @entity303 Rating Scale, and the Stroop Neuropsychological Screening Inventory (Stroop). RESULTS: Serum levels of @entity65361 had a significant negative correlation with recall, learning, and discriminability (factor 1) of the California Verbal Learning Test after adjusting for age and sex (beta=-0.138, P=.019). Subjects with elevated @entity65361 had significantly lower scores (factor 1) than subjects with normal @entity65361 (P<.01). Bivariate analysis showed significant correlations between levels of @entity1255 and the Stroop score and between @entity2186 , @entity15744 , and @entity1255 and some scores of the California Verbal Learning Test, but these relationships did not remain significant after multivariate analysis. Subjects with high @entity1255 (tHcy) had lower Stroop scores than subjects with normal tHcy (P<.05). No biochemical parameters were associated with the @entity303 Rating Scale scores. CONCLUSION: This study indicates that, in normal elderly subjects, some cognitive scores are related to serum @entity65361 and possibly @entity1255 .
