Treatment with @entity2226 , @entity3988 , and @entity270 retards the progressive visual field XXXX : a 3-year follow-up study.

@entity1 @entity2226 @entity227 @entity270 @entity6391 @entity3988
The purpose of this study to assess the effect of the formula @entity2226 / @entity3988 / @entity270 on the progression of @entity227 in @entity6391 . A double blind, placebo controlled study in 62 @entity1 : visual field threshold values were obtained in a Humphrey Field Analyzer from center (30 degrees) and periphery (30-60 degrees), every 4 months during 3-year follow-up. Data were analyzed by univariate regression, with slopes obtained from the best fit lines. Based on slope values, three groups of @entity1 were identified as those showing negative, positive, or zero slope: > or = 1 to < or = +1. In controls (32 @entity1 ), at central area, the distribution in negative, zero, or positive slope was, respectively, 16 (50%), 11 (35%), and 5 (15%). In the treated group (30 @entity1 ) this distribution was 6 (20%) negative, 17 (53%) zero, and 7 (23%) positive slope. In periphery, 16 control @entity1 were distributed as 11 (69%) negative, 4 (25%) zero, and 1 (6%) positive slope. In the treated group (17 @entity1 ), the distribution was opposite: 1 (6%) negative, 7 (41%) zero, and 9 (53%) positive slope. Nineteen @entity1 receiving treatment up to 6 years showed similar distribution by slope values. Eight out of 9 @entity1 switched from placebo (2 years) to treatment (2-3 years), showed improving changes in their slope values. A beneficial effect of the treatment decreasing the rate of @entity227 was observed, likely through a protective action from free radical reactions in affected photoreceptors.
