[Quantitative analysis on in vitro drug sensitivity of cultured XXXX @entity43 cell lines (author's transl)].

@entity1 @entity43 @entity4408 @entity1138 @entity189 @entity19862 @entity420 @entity356 @entity7157
Two cell lines, Kuramochi and CKS, established from @entity1 @entity43 , were analyzed in vitro drug sensitivity to @entity1138 and @entity4408 . These values were compared to those of eight @entity1 @entity356 cell lines composed of various histological types. The CKS cell line, derived from serious @entity7157 , was less sensitive to both test-drugs than the groups of @entity356 cell lines. Therapeutic indices of the two drugs were very low. So it was considered that the two drugs were unsuitable to chemotherapy to @entity19862 . The Kuramochi cell line, derived from undifferentiated @entity189 , was less sensitive to @entity1138 than the groups of @entity356 cell line. However, it was as sensitive to @entity4408 as high-sensitive @entity356 cell lines. Therapeutic index of the @entity4408 in the undifferentiated @entity189 was high. So it was considered that @entity4408 was suitable to chemotherapy to undifferentiated @entity420 . The cytocydal actions of the two drugs were dependent upon dose and time. Time-dependency was, however, smaller in @entity4408 than in @entity1138 .
