Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode XXXX : A Near-Infrared Spectroscopy Study.

@entity1 @entity245 @entity149 @entity161 @entity716 @entity2359
UNASSIGNED: A longer duration of untreated @entity716 (DUP) has been associated with poor clinical outcomes in @entity1 with @entity161 ( @entity161 ); however, it remains unclear whether this is due to @entity2359 effects of @entity716 . The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in @entity1 with first-episode @entity161 (FES). A total of 28 FES @entity1 and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES @entity1 . However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because @entity245 result in @entity149 long before psychotic symptoms onset.
