Tumour antigen expression in XXXX in a low-endemic western area.

@entity1 @entity70723 @entity24984 @entity10784 @entity2355 @entity15693 @entity1956 @entity56388 @entity5 @entity96 @entity7488 @entity16412 @entity6472 @entity26951 @entity160 @entity16051 @entity3969 @entity157
BACKGROUND: Identification of @entity5 antigens is crucial for the development of vaccination strategies against @entity157 ( @entity157 ). Most studies come from eastern-Asia, where @entity1956 is the main cause of @entity157 . However, @entity5 antigen expression is poorly studied in low-endemic, western areas where the aetiology of @entity157 differs. METHODS: We constructed tissue microarrays from resected @entity157 tissue of 133 @entity1 . Expression of a comprehensive panel of @entity5 ( @entity6472 , @entity70723 , @entity56388 , @entity7488 , MAGE-C2, @entity16051 , @entity24984 , @entity26951 ), onco-fetal ( @entity160 , @entity16412 ) and @entity5 antigens ( @entity10784 , @entity3969 -1, Survivin, Midkine, @entity2355 ) was determined by immunohistochemistry. RESULTS: A higher prevalence of MAGE antigens was observed in @entity1 with @entity1956 . @entity1 with expression of more @entity5 antigens in general had better @entity157 -specific survival (P=0.022). The four @entity5 antigens with high expression in @entity157 and no, or weak, expression in surrounding @entity96 , were @entity10784 , @entity16412 , @entity7488 and MAGE-C2, expressed in 90, 39, 17 and 20% of HCCs, respectively. Ninety-five percent of HCCs expressed at least one of these four @entity5 antigens. Interestingly, @entity16412 was associated with @entity15693 expression (P=0.001), an oncofetal transcription factor highly expressed in embryonal stem cells. @entity15693 and @entity16412 expression levels were correlated with vascular invasion, poor differentiation and higher @entity160 levels before surgery. Moreover, @entity1 who co-expressed higher levels of both @entity16412 and @entity15693 had worse @entity157 -specific survival (P=0.018). CONCLUSIONS: We describe a panel of four @entity5 antigens with excellent coverage and good @entity5 specificity in a western area, low-endemic for @entity1956 . The association between @entity16412 and @entity15693 is a novel finding and suggests that @entity16412 targeting may specifically attack the @entity5 stem-cell compartment.
