Infusion of XXXX ('Diprivan') as sedative technique for colonoscopies.

@entity1 @entity2730 @entity1875 @entity158
Sixty male and female @entity1 , scheduled for colonoscopy were premedicated with glycopyrrolate 0.4 mg intramuscularly. Anaesthesia was induced with 2 mg/kg @entity1875 ('Diprivan') and maintained with a continuous infusion of @entity1875 at a rate of 3, 6 or 9 mg/kg/h randomly allocated. @entity1 lost consciousness within 60.6 +/- 18.7 (s.d.) s. Preservation of the hypnotic effect was infusion-rate dependent as 15, 40 and 85% of the @entity1 were unconscious on infusion rates of 3, 6 or 9 mg/kg/h @entity1875 , respectively. A high degree of sedation was observed in the remaining @entity1 with an incidence of 40, 35 and 0% in the different series. Sedation was light in the remainder of the @entity1 . To increase the acceptability of the procedure, a supplemental bolus of @entity1875 and/or an increase in the infusion rate were required in 40, 15 and 10% of the 3, 6 and 9 mg/kg/h infusion rate groups, respectively. The incidence of @entity2730 was similar in all three groups (80, 90 and 95%, respectively). Recovery was significantly longer with increasing infusion rate, but remained rapid. The longest time was 7.3 +/- 4.0 min to open eyes on command and 10.6 +/- 4.6 min to answer correctly. The most important side effects were @entity158 on injection (50%) and some restlessness during maintenance (25%). Blood pressure decreased, but heart rate was unaffected. @entity1 breathed room-air spontaneously. Respiratory rate slowed after induction then increased rapidly above baseline values. The incidence of apnoea was 48% with a mean duration of 51 +/- 22s (s.d.). The technique was evaluated as good or adequate in 95% of the cases. We suggest than an analgesic premedication followed by an average of 6 mg/kg/h @entity1875 by infusion might be a simple and convenient method of achieving good conditions for colonoscopy.
