@entity413 and XXXX metabolism after penetrating ballistic-like @entity1545 .

@entity1545 @entity131 @entity2806 @entity209 @entity26 @entity179 @entity35 @entity204 @entity413 @entity130
UNASSIGNED: @entity131 ( @entity131 ) is a major cause of @entity204 and disability in all age groups. Among @entity131 , penetrating @entity131 (PTBI) have the worst prognosis and represent the leading cause of @entity131 -related morbidity and @entity204 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity35 model: penetrating ballistic-like @entity1545 (PBBI). Early after injury, regional cerebral @entity26 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity413 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity209 and @entity179 . As expected, the injury core had the most severe @entity209 and @entity179 . However, in the peri-lesional area, despite similar @entity209 , there was lesser @entity179 . Given our findings, the data suggest the presence of two distinct zones of @entity130 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity2806 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.
