Survival and trends of occurrence of XXXX , gender differences, 1967-92: The Reykjavik Study.

@entity1 @entity1619 @entity1184 @entity24304 @entity4346 @entity299 @entity583
OBJECTIVE: We estimated the prevalence, incidence and risk factors of @entity4346 ( @entity4346 ) in a prospective cohort study of 26 489 @entity1 . MATERIAL AND METHODS: The @entity4346 was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other @entity1 in the Reykjavik Study stages I-V. RESULTS: A total of 297 @entity1 and 49 @entity1 were found to have @entity4346 of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst @entity1 and six per 1000 per year amongst @entity1 . Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent @entity583 ( @entity583 ) (OR 3.18; 95% CI: 1.39-7.27) and @entity1619 changes (OR 3.06; 95% CI: 2.14-4.38) amongst @entity1 and systolic blood pressure and age for @entity1 with similar odds ratio. Predictive factors for acquiring @entity4346 were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst @entity1 and systolic blood pressure amongst @entity1 ( @entity24304 .03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst @entity1 with @entity1184 [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of @entity4346 (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of @entity4346 and its appearance is associated with age and increased blood pressure amongst both genders. @entity1 with @entity4346 have poorer survival than other @entity1 and they are at threefold risk of dying of @entity299 .
