Unique database study linking XXXX and smoking in carcinogenesis.

@entity5 @entity32 @entity1
We investigated statistical association between @entity32 and @entity5 in a group of @entity1 followed up for 26 years with the hypothesis that @entity32 affects carcinogenesis. Altogether, 1676 30- to 40-year-old subjects from Stockholm were clinically examined in 1985. In 2011, we compared the baseline oral examination and follow-up data with @entity5 diagnoses sourced from the Swedish national hospital register databases. Of 1676 individuals, 89 (55 @entity1 , 34 @entity1 ) had got @entity5 by the year 2011. @entity1 were found to be at higher risk for @entity5 than @entity1 . Smoking (expressed in pack-years) had been more prevalent in the @entity5 group than in those with no @entity5 diagnosis. Gingival index, marker of @entity32 , was higher in the @entity5 group than in subjects with no @entity5 . There were no significant differences between the groups regarding age, education, dental plaque and calculus index scores, or in the number of missing teeth. In multiple logistic regression analysis with @entity5 as the dependent variable and several independent variables, pack-years of smoking appeared to be a principal independent predictor with odds ratio (OR) 1.32 while @entity32 showed OR 1.29. Hence, our present findings showed that together with smoking, @entity32 indeed associated with the incidence of @entity5 in this cohort.
