High-Resolution Intracranial Pressure Burden and Outcome in XXXX .

@entity1 @entity510 @entity1756 @entity428
BACKGROUND AND PURPOSE: @entity428 ( @entity428 ) control is a therapeutic target in @entity1 with @entity510 , although only a limited number of studies assessed its course and effect on outcome. Pressure-time dose (PTDICP) is a method to quantify the burden and the time spent above a defined threshold of @entity428 . PTDICP or its relationship with outcome has never been evaluated in @entity510 . METHODS: Analysis of data prospectively collected from @entity510 @entity1 admitted to Neurointensive Care Unit. Monitored data, including @entity428 , were digitally recorded minute-by-minute in the first 7 days. PTDICP (mm Hg h) was computed using 4 predefined thresholds (15, 20, 25, and 30 mm Hg). Outcome was assessed through Extended Glasgow Outcome Scale at hospital discharge and at 6 months. RESULTS: Fifty-five @entity1 were enrolled. Forty-two @entity1 (76%) presented with a poor clinical grade. Overall, mortality was 17% at hospital discharge and 34% at 6 months. Half of @entity1 required extensive therapy to control high @entity428 during day 1. Median @entity428 was 10 mm Hg (4-75), whereas median PTDICP15, PTDICP20, PTDICP25, PTDICP30 were, respectively, 13, 4, 2, and 1 mm Hg h. We observed an association between mortality at hospital discharge and higher level of PTDICP using 20, 25, and 30 mm Hg as thresholds and between exposure to a moderate-level PTDICP30 and unfavorable long-term outcome. CONCLUSIONS: PTDICP may better define one of the insults that the brain suffers after @entity1756 , and exposure to moderate PTDICP30 was significant prognostic factor of 6-month unfavorable outcome.
