Nano-Se attenuates cyclophosphamide-induced XXXX through modulation of oxidative stress and DNA damage in Swiss albino @entity19 .

@entity1 @entity137 @entity82 @entity66 @entity5 @entity72029 @entity19 @entity5533 @entity651 @entity358 @entity236 @entity8769 @entity2383
Chemotherapy is an integral part of modern day treatment regimen but anticancer drugs fail to demarcate between cancerous and normal cells thereby causing severe form of systemic @entity137 . Among which @entity358 is a dreadful complication developed in @entity5 @entity1 upon cyclophosphamide (CP) therapy. @entity66 , @entity82 , and apoptosis are the major patho-mechanisms involved in CP-induced @entity358 . In the present study, we have synthesized Nano-Se, nanotechnology-based new form of elemental selenium which has significantly lower @entity137 and acceptable bioavailability. In order to meet the need of effective drugs against CP-induced adverse effects, nano selenium (Nano-Se) was tested for its possible protective efficacy on CP-induced @entity358 and @entity236 . @entity8769 resulted in @entity2383 which was revealed by massive histopathological changes. @entity651 was associated with oxidative stress/lipid peroxidation as evident by increased in reactive oxygen species, nitric oxide level, and malondialdehyde (MDA) formation with decreased in level of antioxidants such as reduced glutathione, @entity72029 , glutathione peroxidase, superoxide dismutase, and @entity5533 . Furthermore, CP at a dose of 25  mg/kg b.w. increased pulmonary DNA damage ('comet tail') and triggered DNA fragmentation and apoptosis in @entity19 @entity236 . On the other hand, Nano-Se at a dose of 2  mg  Se/kg b.w., significantly inhibited CP-induced DNA damage in bronchoalveolar lavage cells, and decreased the apoptosis and percentage of DNA fragmentation in @entity236 and also antagonized the reduction of the activities of antioxidant enzymes and the increase level of MDA. Thus, our results suggest that Nano-Se in pre- and co-administration may serve as a promising preventive strategy against CP-induced @entity358 .
