Endocrine regulation of XXXX organic anion transporters.

@entity230 @entity72484 @entity15822 @entity11249 @entity15823 @entity35 @entity3800
Messenger RNA levels of @entity35 @entity15822 ( @entity15822 ; @entity15822 ) and @entity72484 ( @entity72484 ) in kidney and @entity15823 ( @entity15823 ) in liver are gender-predominant. @entity15822 and @entity15823 are male-predominant, whereas @entity72484 is female-predominant. Gonadectomized and hypophysectomized (HX) @entity35 were studied to determine whether sex @entity230 and/or @entity11249 ( @entity11249 ) are responsible for these gender-divergent patterns. @entity11249 was administered to HX @entity35 by two daily injections (simulating male secretion) or continuous infusion (simulating female secretion). @entity15822 mRNA levels, normally higher in male than female kidney, were lowered by gonadectomy and HX in male @entity35 , but not in females. Additionally, @entity11249 injections or infusion did not alter @entity15822 levels in HX @entity35 . @entity72484 mRNA levels, typically much higher in female than in male kidney, were unaffected by gonadectomy. However, HX dramatically decreased @entity72484 in female kidney without altering male levels. @entity11249 administered by continuous infusion increased @entity72484 in kidneys of both HX male and female @entity35 , whereas injections had no affect. Gonadectomy reduced @entity15823 mRNA levels in male livers without affecting levels in female livers. In contrast, HX decreased male and elevated female @entity15823 mRNA. @entity11249 injections did not significantly change @entity15823 mRNA levels in HX @entity35 , but infusion decreased @entity15823 mRNA in liver. In conclusion, @entity3800 , but not @entity11249 , are responsible for the @entity15822 mRNA gender difference in kidney; the female @entity11249 secretion pattern is responsible for the @entity72484 mRNA gender difference in kidney; and both @entity3800 and the female @entity11249 secretion pattern are responsible for the @entity15823 mRNA gender difference in liver.
