Increased diffusion in the normal appearing white matter of brain tumor XXXX : is this just @entity5 infiltration?

@entity11 @entity1 @entity1653 @entity5
UNASSIGNED: Altered diffusion in the normal appearing white matter (NAWM) of @entity11 @entity1 has been explained by @entity5 infiltration. The goal of the present study was to test this explanation indirectly by examining whether these alterations were also present in the contralateral NAWM of non-infiltrative @entity5 like @entity1653 ; and to search for other possible reasons for this abnormality. Twenty-seven @entity1 with histologically verified @entity11 (grade II-IV), 22 @entity1653 @entity1 and two groups of age- and sex-matched healthy controls underwent diffusion weighted imaging (DWI) on a 3T MR. All @entity1 were examined before treatment. Apparent diffusion coefficient (ADC) values were calculated in the entire NAWM of the hemisphere contralateral to the @entity5 . ADC values of the NAWM were compared between groups with Mann-Whitney U-test and multiple linear regression. The relations of ADC in NAWM to @entity11 grade and to @entity5 volume were also investigated. ADC values of the contralateral NAWM were significantly higher in both @entity11 and @entity1653 @entity1 compared to controls (P  =  0.0006 and 0.0099, respectively). ADC value was higher in the NAWM of high grade @entity11 than in low grade @entity11 (P  =  0.0181) and in healthy control subjects (P  =  0.0003). ADC did not depend on @entity5 volume in any of the @entity1 groups. Elevated ADC in the NAWM of both @entity11 and @entity1653 @entity1 might indicate that the effect of infiltrating @entity5 cells is not the only reason for the alteration as it has been previously suggested. Although the role of mass effect was not proved, other mechanisms might also contribute to ADC elevation.
