Analysis of predictive factors for recurrence after hepatectomy for XXXX .

@entity1 @entity5 @entity1600 @entity3 @entity14
Hepatectomy for liver metastases from @entity14 has recently received general acceptance as a safe, potentially curative treatment. Most @entity1 , however, die of recurrent disease after hepatectomy. The predictive factors for recurrence after first resection of liver metastases have not yet been clarified. The authors aimed to determine the factors that can predict recurrence, especially hepatic-only recurrence after hepatectomy for @entity14 . Seventy-six @entity1 who underwent liver resection of colorectal metastases were studied retrospectively. Forty-seven (61.8%) of the @entity1 had a recurrence. The @entity1 ' disease-free survival after first hepatectomy and the second recurrence sites were univariately and multivariately analyzed using 16 clinicopathologic variables. Wall invasion, @entity1600 , lymphatic invasion, venous invasion of the @entity5 , 24 months or longer disease-free interval after resection of the primary @entity14 , and bilateral liver metastases significantly influenced the disease-free survival (log-rank test: p < 0.05). The multivariate analysis revealed that venous invasion of the @entity5 and bilateral hepatic metastases were independent risk factors for recurrence after hepatectomy. The liver was the only site of second recurrence in 23 @entity1 . @entity1 with @entity1600 and venous invasion of the @entity5 had a significant difference between hepatic-only and extrahepatic recurrence after first hepatectomy (chi-square test or Fishers' exact test: p < 0.05). Recurrence after hepatectomy was influenced more by factors associated with the primary @entity14 than factors surrounding the first liver metastases. @entity3 of the primary @entity14 was the most important predictable factor for hepatic-only second recurrence.
