Lung structural remodeling and @entity120 after @entity583 : complete reversal with XXXX .

@entity712 @entity3126 @entity1808 @entity120 @entity7056 @entity8158 @entity1188 @entity35 @entity583
OBJECTIVES: The severity of @entity120 associated with @entity712 carries a poor prognosis. The lungs are very sensitive to the constrictive and proliferative effects of @entity1808 and could represent a preferential target for this peptide. METHODS: @entity35 with large @entity583 or sham surgery received the @entity1808 receptor antagonist @entity7056 (40 mg/kg/day) or vehicle for 2 or 8 weeks (n=5 to 8 for each group). Hemodynamic and morphometric measurements were obtained followed by immunohistochemistry, immunofluorescence analysis and electron microscopic characterization of lung sections. RESULTS: The @entity1188 groups developed @entity120 and @entity8158 with elevated left ventricular filling pressures (all P<0.01). Despite similar @entity1188 size, filling pressures were lower (P<0.01) while @entity120 and @entity8158 were completely normalized by @entity7056 . Isolated lungs pressure-flow relationships were identical at 2 weeks. At 8 weeks it was steepest and shifted upward in the @entity1188 group (P<0.001), and completely normalized by @entity7056 . Lung weight doubled after @entity1188 with no evidence of @entity3126 and was also normalized by @entity7056 . Important lungs structural remodeling evidenced by collagen and reticulin deposition, thickening of the alveolar septa and proliferation of cells with ultrastructural characteristics of myofibroblasts (pericytes) were identified after @entity1188 . CONCLUSIONS: After large @entity583 there is important pulmonary structural remodeling in which myofibroblasts (pericytes) proliferation may play an important role. This initially protective mechanism against high filling pressures could eventually contribute to the development of @entity120 and @entity8158 . Future studies are needed to determine if @entity1808 directly modulates pulmonary remodeling after @entity583 .
