expression patterns of cyclins D1 and E in @entity6205 in comparison with XXXX .

@entity1364 @entity6205 @entity1569 @entity1083 @entity75 @entity4910 @entity1082 @entity39150
@entity1082 ) is able to subvert the host cell replication machinery so as to foster viral reproduction. Specifically, @entity1083 is known to induce expression of proliferation antigens such as Ki67 and proliferative cell nuclear antigen ( @entity1364 ) in differentiated keratinocytes which have ceased to replicate. In order to determine whether @entity4910 or cyclin E deregulation is also a feature of @entity1083 , an immunohistochemical investigation of @entity4910 , cyclin E, Ki67, and @entity1364 expression has been carried out in 38 cases of HPV 6/11-related @entity6205 ( @entity6205 ). Results were compared with those obtained from 15 @entity75 . Whereas 35 (92.1 per cent) @entity6205 samples exhibited positive nuclear immunostaining for cyclin E, no @entity4910 immunoreaction was detected in any of the @entity6205 samples studied. All @entity75 showed immunostaining for both cyclins. All @entity6205 cases revealed a positive immunoreaction for Ki67 and 33 for @entity1364 , both in the parabasal and in the differentiated upper epithelial layers. Parabasal keratinocytes of @entity75 were always positive for both Ki67 and @entity1364 . These results indicate that in the onslaught of HPV 6/11 upon the keratinocyte replication machinery, cyclin E, @entity1364 , and Ki67 are amongst the targeted cell cycle modulators, whereas @entity4910 is spared the main effects of virus-cell interplay. In contrast, both cyclins seem to be induced in @entity1569 , @entity39150 .
