The impact of chemotherapy for XXXX on sexual function and health-related quality of life.

@entity1 @entity308 @entity0
PURPOSE: In this prospective trial, we evaluated the influence of chemotherapy for @entity0 on @entity1 's health-related quality of life (HR-QoL), sexual function, and mental status. METHODS: The @entity1 completed validated questionnaires on HR-QoL, sexual function, and @entity308 before, during, and at the end and finally 6  months after chemotherapy. Special attention was paid to possible differences between pre- and postmenopausal @entity1 . RESULTS: Between 2008 and 2012, 79 @entity1 were enrolled in the trial (mean age 47.46  years). Premenopausal @entity1 were 63.3  %. Sexual activity dropped from 71.9  % before chemotherapy to a minimum of 47  % at the end of chemotherapy. A similar effect was seen for pleasure and discomfort. @entity308 values were the highest at the beginning of chemotherapy, with spontaneous improvement in many @entity1 during the course of time. HR-QoL and global health status both increased 6  months after therapy. For almost all parameters, changes were more obvious in pre- than in postmenopausal @entity1 . CONCLUSIONS: In a close monitoring, we observed significant changes in HR-QoL, @entity308 , and sexual function in @entity0 @entity1 . Special attention needs to be paid to premenopausal @entity1 . The knowledge of effective recovery and spontaneous improvement of HR-QoL in spite of still impaired sexuality are important information in counseling both pre- and postmenopausal @entity1 with diagnosis of @entity0 prior to upcoming therapy.
