@entity1358 ( XXXX ) and telomerase activity: relationship to stage.

@entity1 @entity66 @entity5 @entity1711 @entity1358 @entity1710 @entity1442 @entity3 @entity1349
Limited information is available on the correlation of telomerase activity and the clinical and pathological characteristics, in @entity1 with @entity1358 ( @entity1358 ). Telomerase repeat amplification protocol (TRAP) was used to measure telomerase activity in frozen @entity1358 specimens from partial/radical nephrectomies performed between 1987 and 1991. Presence of @entity5 tissue was verified by a pathologist using @entity1710 and @entity1711 stained sections. RNA was measured to ensure the presence of intact protein necessary for telomerase expression. Data on demographics, @entity5 type, and stage at presentation, local recurrence, distant @entity3 , @entity66 ( @entity66 ), and @entity1349 ( @entity1349 ) was collected, and telomerase activity was correlated with each of these variables. Forty-nine of 67 @entity1 (73%) were telomerase positive (+ve). Gender and stage were the only variables that appeared to be associated with telomerase positivity. @entity5 were telomerase +ve in 12/21 females (57 %) vs. 37/46 males (80%) (P = 0.07). @entity5 were telomerase +ve in 85% of Stage IV, 76% of Stage III, and 70% of Stage I/II @entity1 (P = 0.12). Five-year survival was 0% for Stage IV, 57% for Stage III, and 77% for Stage I/II @entity1 (P < 0.001), @entity66 54% for stage III and 84% for Stage I/II @entity1 (P = 0.05). Telomerase activity, however, was not related to survival in either univariate or multivariate analysis. In @entity1 with telomerase +ve @entity5 5-year survival was 55%, and with @entity5 58% (P = 0.56). Stage was the only variable associated with @entity1349 or @entity66 in clear cell @entity1358 @entity1 . In @entity1 with @entity1442 , there is a high incidence of telomerase positivity was found, within this limited sample, however, no correlation with survival was found.
