Long-term XXXX and psychosocial outcomes after resective surgery for intractable @entity302 .

@entity1 @entity410 @entity302
UNASSIGNED: Resective surgery is considered an effective treatment for refractory localization-related @entity302 . Most studies have reported @entity410 and psychosocial outcomes of 2-5years postsurgery and a few up to 10years. Our study aimed to assess long-term (up to 15years) postsurgical @entity410 and psychosocial outcomes at our @entity302 center. The Henry Ford Health System Corporate Data Store was accessed to identify @entity1 who had undergone surgical resection for localization-related @entity302 from 1993 to 2011. Demographics including age at @entity302 onset and surgery, @entity410 frequency before surgery, and pathology were gathered from electronic medical records. Phone surveys were conducted from May 2012 to January 2013 to determine @entity1 ' current @entity410 frequency and psychosocial metrics including driving and employment status and use of antidepressants. Surgical outcomes were based on Engel's classification (classes I and II=favorable outcomes). McNemar's tests, chi-square tests, two sample t-tests, and Wilcoxon two sample tests were used to analyze the relationships of psychosocial and surgical outcomes with demographic and surgical characteristics. A total of 470 @entity1 had resective @entity302 surgery, and of those, 50 (11%) had died since surgery. Of the remaining, 253 (60%) were contacted with mean follow-up of 10.6  5.0years (27% of @entity1 had follow-up of 15years or longer). Of the @entity1 surveyed, 32% were @entity410 -free and 75% had a favorable outcome (classes I and II). Favorable outcomes had significant associations with temporal resection (78% temporal vs 58% extratemporal, p=0.01) and when surgery was performed after scalp EEG only (85% vs 65%, p<0.001). Most importantly, favorable and @entity410 -free outcome rates remained stable after surgery over long-term follow-up [i.e., <5years (77%, 41%), 5-10years (67%, 29%), 10-15years (78%, 38%), and >15years (78%, 26%)]. Compared to before surgery, @entity1 at the time of the survey were more likely to be driving (51% vs 35%, p<0.001) and using antidepressants (30% vs 22%, p=0.013) but less likely to be working full-time (23% vs 42%, p<0.001). A large majority of @entity1 (92%) considered @entity302 surgery worthwhile regardless of the resection site, and this was associated with favorable outcomes (favorable=98% vs unfavorable=74%, p<0.001). The findings suggest that resective @entity302 surgery yields favorable long-term postoperative @entity410 and psychosocial outcomes.
