Facial infiltrating XXXX .

@entity1 @entity4670 @entity8481 @entity51280 @entity1184 @entity2478 @entity6574 @entity203 @entity1050 @entity18015 @entity11124
Facial infiltrating @entity6574 is a rare @entity4670 in which mature lipocytes invade adjacent tissue. The phenotypic features include soft-tissue and skeletal @entity1184 , @entity203 , and regional @entity51280 . There is a high risk for regrowth after resection that is, perforce, subtotal. The etiology, natural history, optimal management, and relationship to other @entity8481 are unclear. In this study, the clinical features, radiographic findings, histopathology, and postoperative results were analyzed in 13 @entity1 with facial infiltrating @entity6574 . The condition was diagnosed in infancy (eight male subjects, five female subjects) and characterized by enlargement of the cheek (n = 12) or chin (n = 1). Other findings included cutaneous @entity2478 (n = 9), @entity11124 (n = 8), and @entity18015 (n = 6). Most @entity1 had early eruption of ipsilateral deciduous and permanent teeth (n = 12). Computed tomography and magnetic resonance imaging showed an infiltrated soft-tissue mass of fatty density (n = 13) and skeletal overgrowth (n = 9). Multiple resection was performed on six @entity1 (mean number of operations per @entity1 , 2.5; range, one to six operations); regrowth and/or worsening of the capillary stain occurred in all six @entity1 . Because surgical removal of the mass is usually unsuccessful, specific management of this condition will require insight into its etiopathogenesis. Given the presence of @entity18015 and @entity6574 , this study included testing for the known mutations in three entities that are associated with these soft-tissue findings ( @entity1050 , @entity1050 , and @entity18015 ). Results of DNA analyses for these germline mutations were negative. It is more likely that this disorder is caused by a somatic mutation involving a local increase in growth factor(s).
