Bone Mineral Density as a Predictor of Subsequent Wrist Fractures: Findings From the XXXX 's Health Initiative Study.

@entity1 @entity3604 @entity10479 @entity174 @entity79
CONTEXT: Wrist @entity174 are common among postmenopausal @entity1 . Associations of @entity79 ( @entity79 ) and 10-year predicted risk of @entity3604 ( @entity3604 ) with wrist @entity174 are poorly characterized. OBJECTIVE: The objective was to examine associations between the Fracture Risk Assessment Tool (FRAX)-predicted risk of @entity3604 , @entity79 , @entity79 change, and wrist @entity174 . DESIGN: This was a prospective observational study with a mean follow-up of 8.5 years. SETTING: This study included 40 @entity10479 centers. @entity1 : A total of 11 392 @entity1 from the @entity1 's Health Initiative @entity79 Cohort aged 50-79 years at baseline were included in this study. INTERVENTIONS: None. MAIN OUTCOME: The goal was to measure incident wrist @entity174 . RESULTS: A FRAX-predicted @entity3604 risk >= 9.3% identified 17% of the @entity1 aged <65 years who subsequently experienced wrist @entity174 . Each one standard deviation lower @entity79 was associated with higher wrist @entity174 risk, with adjusted hazard ratio (95% confidence interval) of 1.66 (1.42-1.93) for femoral neck (FN) @entity79 and 1.45 (1.28-1.64) for lumbar spine @entity79 . Compared with FN @entity79 T score >=  -1.0, wrist @entity174 adjusted hazard ratios (95% confidence interval) were: 1.51 (1.06-2.16) for a T score between -1.01 and -1.49; 1.93 (1.36-2.72) for T score between -1.50 and -1.99; 2.52 (1.77-3.60) for a T score between -2.00 and -2.49; and 2.65 (1.78-3.95) for a T score  <= -2.5. Decrease in FN @entity79 between baseline and year 3 was associated with increased risk of subsequent wrist @entity174 ; however, change in lumbar spine @entity79 was not. CONCLUSIONS: Lumbar spine and femoral neck BMDs were associated with incident wrist @entity174 , but the FRAX threshold recommended to identify screening candidates did not identify the majority of @entity1 who subsequently experienced wrist @entity174 . Improved understanding of determinants of wrist @entity174 is warranted.
