Residual lymph node status is an independent prognostic factor in XXXX with pathologic T0 after preoperative radiotherapy.

@entity1 @entity5 @entity1721 @entity1349
OBJECTIVE: To evaluate the prognostic factors affecting survival in @entity1721 ( @entity1721 ) @entity1 with pathologic T0 (ypT0) underwent preoperative radiotherapy. @entity1 AND METHODS: Two hundred and ninety-six @entity1 with @entity1721 who had received preoperative radiotherapy from 1980 to 2007 were retrospectively analyzed. One hundred @entity1 were ypT0 after preoperative radiotherapy. Univariate and multivariate analyses were performed to evaluate the predictive impact of residual lymph node status on @entity1349 ( @entity1349 ) and progression-free survival (PFS). RESULTS: Among the originally analyzed 296 @entity1 , 100 (33.7  %) @entity1 had ypT0, including 78 @entity1 (78  %) with ypT0N0, and 22 @entity1 (22  %) with ypT0N1. The 5-year @entity1349 of the total @entity1 was 42.4  %. @entity1 with ypT0N0 have significant improved 5-year @entity1349 and PFS than ypT0N1 @entity1 ( @entity1349 : 50.7  % vs 13.6  %, P   =   0.004; PFS: 49.6  % vs 13.6  %, P   =   0.003). In multivariate analysis, residual lymph node status was also an independent prognostic factors for @entity1349 (HR: 0.406, 95  % CI: 0.240-0.686, P   =   0.001) and PFS (HR: 0.427, 95  % CI: 0.248-0.734, P   =   0.002). CONCLUSION: Our results indicate that @entity1 with ypT0N0 after preoperative radiotherapy had significantly better @entity1349 and PFS than @entity1 with ypT0N1 in @entity1721 . Residual nodal metastasis of @entity1721 @entity1 with pathological complete response of the @entity5 after neoadjuvant radiotherapy does influence prognosis.
