@entity28585 : A rapid detoxification protocol for the conversion from intrathecal XXXX --the Raffaeli Detoxification Model.

@entity1 @entity7988 @entity3347 @entity1340 @entity28585 @entity1286 @entity158 @entity1338 @entity2934
OBJECTIVES: To assess the efficacy and the safety of our rapid detoxificationprotocol in preventing signs and symptoms of withdrawal and @entity158 severity. DESIGN: Prospective, open-label case series study. SETTINGS: Public primary care at the @entity158 and Palliative Care Unit of the Infermi Hospital of Rimini, Italy. @entity1 : The authors studied 10 consecutive @entity1 suffering from chronic noncancer @entity158 who were refractory to intrathecal (IT) @entity1286 , and hence indicated for @entity28585 therapy. INTERVENTIONS: IT pump was refilled with saline solution, and each @entity1 received endovenous @entity1286 , oral @entity1338 , @entity7988 , and @entity2934 for the first 3 days, and slow-release @entity1340 , oral @entity1338 , and @entity7988 for 10 days. @entity28585 therapy was started at the end of the 2-week detoxification treatment. MAIN OUTCOME MEASURES: The observer-rated opioid withdrawal scale (OOWS) was used for the assessment of @entity3347 , visual analogue scale was used for @entity158 intensity assessment, and also adverse events were recorded. RESULTS: @entity3347 were experienced by 3 @entity1 (30 percent). Their average OOWS decreased significantly (p < 0.05) from 4.3 +/- 2.5 to 1.7 +/- 0.6 at days 3 and 14 of protocol, respectively, with no increment of @entity158 intensity. @entity3347 were resolved in 4 days on average without the need of adjuvant medications. One @entity1 with high @entity1286 dosage (20 mg/d), interestingly, did not show any @entity3347 . CONCLUSIONS: The detoxification protocol was effective in preventing @entity3347 without increasing @entity158 severity, allowing to rapidly convert IT @entity1286 to @entity28585 monotherapy in @entity1 who are refractory to @entity1286 .
