Outcome of long-term vagus nerve stimulation for XXXX .

@entity1 @entity410 @entity302
The outcome of long-term vagus nerve stimulation (VNS) was evaluated in 13 Japanese @entity1 with @entity302 , all followed up for more than 4 years (48-91 months, median 56 months). VNS achieved a long-lasting and cumulative @entity410 -control effect in nine of 13 @entity1 . The mean reduction of @entity410 frequency in the 1st to 4th year was 28%, 47%, 54%, and 63%, respectively. The percentage of @entity1 with >60% @entity410 reduction in the 1st to 4th year was 15%, 46%, 54%, and 69%, respectively. One @entity1 did not respond to the treatment at all. No @entity1 became completely free from @entity410 or free from medication, but the number and/or dosage of antiepileptic drugs was reduced in five @entity1 . Ten @entity1 underwent exchange of the generator and continued treatment, and two @entity1 underwent removal of the generator because of the unsatisfactory result. VNS controlled more disabling @entity410 earlier and more efficiently than less disabling @entity410 in seven @entity1 . The cumulative reduction of @entity410 was partly associated with changes in the device setting toward increased stimulation. These effects were similar in @entity1 with or without previous resective surgery. Long-term VNS therapy achieved a favorable outcome in a significant proportion of @entity1 with @entity302 .
