[Evolution of the number of incident cases of XXXX in France from 2001 to 2012 from 5 hospital centers.]

@entity1 @entity263 @entity5
OBJECTIVES: The main objective is the study of the evolution of the number of incident cases of @entity263 in France from 2001 to 2012 from 5 hospital centers of urology. The secondary objective is to describe the characteristics of the incident cases and to compare them to those of the @entity1 of the national registers of @entity5 for the period. MATERIAL AND METHODS: Prospective observational multicentric study from 01/01/2001 to 31/12/2012 of databases in 5 French, public and private hospital centers of urology. The inclusive centers were selected outside departments with @entity5 register. The collected data were the prostatic biopsies performed in every center and the number of positive biopsies. The biopsies in cases of already known @entity5 and in re-evaluation were excluded. The data of age and stage (PSA and Gleason grade) were collected. The estimation of the incidence standardized in France is established after a period of observation of 3  years. The data updated in 2009 show a peak of incidence in 2005 then a decrease from 2006 (64,518 cases) until 2009 (53,465 cases). The median age in the diagnosis was of 70 years in 2005. RESULTS: Overall, 18,392 prostatic biopsies were included in the analysis. The average rate of positive biopsies was stable over the period 51.41% (IQR 0,02). The total number of cases of positive biopsies increased from 2001 to 2007 (482 cases in 1028 cases) in 2007, then decreased from 2008 to 2012 (649 cases). There was no difference in this variation between the centers. The median age in the diagnosis was of 70 years (EIQ=1.5) in 2001 and 68 years (EIQ=2.75) in 2012. PSA at diagnosis was<10ng/mL in 65% of cases and 10 to 20ng/mL in 22% of cases in 2012. The population of @entity1 of the study differed significantly from that of FRANCIM on the distribution by age ranges (year 2005, P<0.0001 and year 2009, P<0.001), which explains the gap of one year (on 2007 instead of 2006) of the peak of incidental cases. CONCLUSION: The evolution of the number of incidental cases of @entity263 in France from 2001 to 2012 from hospital data of 5  centers are similar to those of the network of registers representative of the French population. This observed evolution represents data available for @entity5 registers to estimate incidence variation between 2  publications. LEVEL OF EVIDENCE: 4.
