Overexpression of the p53 @entity5 suppressor gene product in esophageal and XXXX .

@entity286 @entity5 @entity1721 @entity420 @entity356
PURPOSE: p53 protein has been reported as frequently overexpressed in esophageal and @entity356 . However, the correlation between p53 protein expression and clinico-pathological features of the @entity5 is debated in this heterogeneous group of @entity5 . The aim of this study was to establish the prevalence of p53 protein overexpression in a series of resected @entity1721 (n = 78), @entity420 developed on Barrett's esophagus (n = 20), @entity420 (n = 36), and @entity420 of the antrum (n = 30), and to correlate this expression with the clinico-pathological and flow-cytometric characteristics of the @entity5 . METHODS: Immunohistochemical staining was performed on frozen sections with a monoclonal antibody directed against wild type and mutated p53 protein (Pab 1801). An adjacent frozen specimen was used for flow cytometric determination of the DNA-ploidy and S phase fraction. RESULTS: p53 protein nuclear expression was detected in 76% of @entity1721 , in 75% of @entity420 developed in Barretts esophagus, in 56% of @entity420 , and in 27% of @entity420 of the antrum. Only the number of positive @entity420 of the antrum was significantly lower when compared to the other three types of @entity5 (p = 0.001). No significant correlation was observed between p53 protein expression and most of the clinico-pathological and flow-cytometric parameters (sex, age, @entity286 smoking, chronic alcohol consumption, size of the @entity5 , grade of differentiation, depth of infiltration, presence of lymph node metastases, UICC stage, DNA-ploidy, S phase fraction). p53 protein expression was more frequent in Lauren's intestinal @entity420 (67%) when compared to the @entity5 (24%) (p = 0.002). CONCLUSIONS: Our results confirm that overexpression of p53 protein is a common feature of esophageal and @entity356 . The high prevalence of p53 protein overexpression found in cardiac @entity420 when compared to antral @entity420 reinforces the hypothesis of distinct carcinogenetic mechanisms in these two @entity5 . In particular the lack of correlation between p53 expression and @entity5 stage suggests that p53 protein overexpression is an early event in these @entity5 .
