Plasma hormones in XXXX -exposed females.

@entity1 @entity251 @entity1420 @entity4743 @entity53 @entity3923 @entity1815 @entity4742 @entity2671
Random blood samples were obtained from 114 @entity1 with history of @entity4742 ( @entity4743 ) exposure in utero and were analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), @entity1815 (E1), @entity53 (E2), @entity2671 (A), @entity251 (T), and @entity1420 (P) by respective radioimmunoassays. Colposcopic examinations of the lower genital tract and biopsies of suspicious areas of vaginal mucosa were performed in every @entity1 . The mean age of these @entity1 was 21.6 +/- 0.3 years (mean +/- SE) and mean age of menarche was 12.6 +/- 1.0 years. The incidence of irregular menses was 16.7%. A positive colposcopic finding was observed in 73.7% of all @entity1 , 69.5% of @entity1 with regular menses, and 94.7% of @entity1 with irregular menses. Histologically confirmed vaginal @entity3923 was found in 43% of all @entity1 , 46.3% of @entity1 with regular menses, and 42.1% of @entity1 with irregular menses. No significant differences were observed between @entity4743 -exposed versus unexposed females with regular menses in all hormones except @entity251 . An elevated @entity251 level was noted in postovulatory and perimenstrual phases of @entity4743 -exposed females. Elevated @entity251 was also observed in @entity4743 -exposed females with irregular menses. Cross-analysis of hormone levels among the @entity1 with lower genital tract pathology failed to show any statistical differences.
