The @entity894 : a prognostic factor in XXXX .

@entity1 @entity135 @entity894 @entity5 @entity957 @entity1014
The @entity1014 @entity894 ( @entity894 ), representing the percentage of cells in the DNA-synthesis phase, was measured in vitro prior to therapy in 87 @entity1 with @entity957 of the @entity135 , who were treated between 1977 and 1982. The @entity894 was not related to @entity1 age, site of the @entity5 , clinical stage or histological grade. Overall survival was 44.5%. Univariate analysis demonstrated that survival was affected by the following factors: (1) age: @entity1 older than 55 had a better outcome (p = 0.03); (2) site of the @entity5 (p = 0.005): @entity5 had the best survival; (3) clinical stage (p = 0.05). Histological grade did not influence the survival (p = 0.41). @entity1 having a @entity5 higher than 15.5% (mean + 1 S.D.) had a significantly lower survival than @entity1 with lower @entity5 (p = 0.008). A multivariate analysis using the Cox model showed that clinical stage and @entity894 kept their prognostic impact with regard to survival. Finally, survival after relapse was lower in @entity1 with a high @entity5 . These results demonstrate that a high @entity5 proliferation rate is an additional factor influencing the disease outcome in @entity135 . @entity1 with bad prognosis defined by this parameter could be offered a more energetic treatment.
