Immunohistochemical detection of @entity72603 , @entity41902 , and cytokeratin 20 in @entity235 XXXX .

@entity235 @entity5 @entity1185 @entity957 @entity406 @entity150 @entity41902 @entity72603 @entity982 @entity1606
Immunohistochemistry for @entity72603 ( @entity72603 ), @entity41902 ( @entity41902 ), and cytokeratin 20 (CK 20) using commercially available antibodies was done in normal @entity235 urinary bladder and 72 @entity235 @entity150 that had been fixed in @entity406 and embedded in @entity982 . Prolonged fixation (3-28 days) did not significantly alter the immunostaining for @entity72603 . There was moderate reduction in the intensity for @entity41902 and CK 20 after 1 week of fixation. @entity72603 was detected in superficial (umbrella) cells and some intermediate cells of the normal urinary bladder, 7 of 7 transitional cell @entity1185 (TCPs), 50 of 55 @entity1606 ( @entity1606 ), and 4 of 5 metastatic @entity1606 . Staining was typically outlined in the plasma membrane, but diffuse or focal cytoplasmic staining was also observed. Intracytoplasmic lumina were usually positive for @entity72603 . One @entity957 , 4 nonepithelial @entity150 , and 285 @entity5 from different nonurinary locations were negative for @entity72603 . @entity41902 was detected in 7 of 7 TCPs, 53 of 54 @entity1606 , and 5 of 5 metastatic @entity1606 . The staining for @entity41902 was diffuse cytoplasmic. CK 20 was detected in 1 of 7 TCPs, 37 of 54 @entity1606 , and 1 of 5 metastatic @entity1606 . The staining with CK 20 was cytoplasmic and weaker than with antibodies to @entity72603 or @entity41902 . There was concurrent expression of @entity72603 , @entity41902 , and CK 20 in 36 of 54 @entity1606 . @entity72603 is a specific and sensitive marker for @entity235 transitional epithelial (urothelial) neoplasms, detecting 91% of @entity1606 . Negative results may be observed with @entity5 .
