Nasopharyngeal pneumococcal carriage of @entity1 attending day care centers in Korea: comparison between XXXX immunized with 7-valent pneumococcal conjugate vaccine and non-immunized.

@entity1 @entity114 @entity2929 @entity6831
To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated @entity1 . Vaccinated subjects were recruited from highly vaccinated regions (>=  60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 @entity1 aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non- @entity6831 16.7% (6/36) and @entity6831 ( @entity6831 ) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were @entity6831 . Resistance rates for @entity114 and @entity2929 were lower in the vaccine group (vaccine vs control; @entity114 45.2% vs 71.4%, @entity2929 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in @entity6831 which leads to replacement of pneumococci by antibiotic susceptible VRT or non- @entity6831 strains.
