Fetal Renal Stem Cell Transplant in Nephrotic and XXXX with Stage 2-4 @entity740 : Potential Effect on @entity644 and Glomerular Filtration Rate.

@entity1 @entity644 @entity8 @entity740 @entity1985 @entity631 @entity454
OBJECTIVES: @entity644 is a major cause of @entity631 progression in @entity8 , and the development of @entity454 is more rapid in @entity1985 @entity1 than in nonnephrotic ones. The @entity8 is less regenerable because it is a tissue consisting of renal cells. Thus, stem cells obtained from fetal kidney tissue might be effective for reducing @entity644 and delaying @entity631 in these @entity1 . MATERIALS AND METHODS: This report presents preliminary data from a prospective cohort study that included 17 @entity1 with chronic @entity631 in stage 2 to 4 @entity740 who completed 3 visits during 1 year of follow-up. Fetal renal stem cells (multiple cells in suspension) were injected into the @entity1 every 6 months. @entity1 were divided into 2 groups according to their @entity1985 status, and 24-hour maximal @entity644 was recorded for at least 6 months (first group with @entity644 < 3.5 g/24 h, and second group with @entity644 > 3.5 g/24 h). RESULTS: During follow-up, group 1 was observed to have stable hemoglobin and total protein levels but significantly decreased albumin levels and glomerular filtration rates. In group 2, total protein with serum albumin significantly increased, and @entity644 and glomerular filtration rates significantly decreased. There was no significant difference in glomerular filtration rate decline between groups. CONCLUSIONS: Treatment with fetal renal stem cells significantly decreased @entity644 in @entity1985 @entity1 . However, this outcome also might have resulted from a reduction in glomerular filtration rate. Further studies with a larger number of @entity1 and a control group would help to achieve better results that measure the efficacy of this treatment.
