The Increased Expression of @entity16365 and XXXX in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis.

@entity1 @entity31 @entity406 @entity982 @entity8787 @entity14284 @entity16365
Background/Aims. The aim of this study is to clarify the differences of @entity16365 and @entity14284 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult @entity31 ( @entity31 ) @entity1 . Methods. Onehundred forty-one @entity1 who underwent proctocolectomy were divided to two groups including childhood-onset @entity31 (CUC, <16 years old, n = 24) and adult-onset @entity31 (AUC,    16 years old, n = 117). A total of 141 @entity406 -fixed, @entity982 -embedded tissue samples of rectum were obtained from these @entity1 . Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment. In immunohistochemistry study, the @entity16365 expression was evaluated by intensity and the stained area, and the @entity14284 expression was evaluated by lymphocytes infiltration pattern. Results. @entity16365 score and @entity14284 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of @entity31 in all @entity1 (P < 0.05). @entity16365 and @entity14284 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases (P < 0.05). Conclusions. @entity16365 and @entity14284 may play a significant role in local damage and pathological changes in @entity31 especially pediatric @entity1 . In the future, our understanding of the differences in CCL- @entity14284 interaction between adults and @entity1 may lead to the pathogenesis of @entity8787 .
