Understanding the role of hyperdiploidy in XXXX prognosis: which trisomies really matter?

@entity1582 @entity1 @entity1349
UNASSIGNED: The prognosis of @entity1582 is mainly dependent upon chromosomal changes. The two major abnormalities driving poor outcome are the del(17p) and the t(4;14). However, the outcome of these high-risk @entity1 is not absolutely uniform, some @entity1 presenting long survival. We hypothesized that these better outcomes might be related to concomitant "good risk" chromosomal changes exploring hyperdiploidy. We analyzed a large series of 965 @entity1582 @entity1 including 168 @entity1 with t(4;14) and 126 @entity1 with del(17p) using high throughput SNP arrays after plasma cell sorting. As expected, trisomic chromosomes were highly associated. Using the LASSO model, we found that only chromosome 3 when trisomic was associated with a longer progression free survival and that three trisomies modulated @entity1349 ( @entity1349 ) in @entity1582 @entity1 : Trisomies 3 and 5 significantly improved @entity1349 , and trisomy 21 worsened @entity1349 . Especially in @entity1 with t(4;14), trisomies 3 and/or 5 seemed to overcome the poor prognosis. For the first time, using a specific modelling approach, we show that not all trisomies display the same prognostic impact. This finding could be important for routine assessment of prognosis in @entity1582 , some high-risk @entity1 with a traditional evaluation could be in fact standard risk.
