Correlation between @entity2533 gene @entity57109 single nucleotide polymorphism and clinicopathological characteristics of XXXX .

@entity1 @entity17822 @entity57109 @entity421 @entity2533 @entity3
UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity1 bone. Several polymorphisms have been described in the @entity2533 gene. To explore the correlation between @entity2533 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity421 . TaqMAN PCR technique was used to detect the @entity2533 gene polymorphism of 124 @entity1 with @entity421 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity1 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity421 with logistic regression and different survival rates of different genotypic @entity1 with @entity421 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity2533 gene @entity17822 locus between the @entity1 group and control group (P   =   0.26). However, there are significant distributive differences in @entity57109 genotype (P   =   0.04), which shows that @entity1 carrying TT genotype have more risk to get @entity421 than @entity1 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity1 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity1 carrying CC genotype, @entity1 carrying TT genotype have two times risk of @entity3 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity1 carrying TT genotype. The morbidity and @entity3 of @entity421 are relevant to @entity2533 gene @entity57109 single nucleotide polymorphism.
