Dysfunction and XXXX associated with cardiac valve xenografts in adults.

@entity1 @entity117 @entity1031 @entity955 @entity340 @entity1229 @entity884
Cardiac valve xenografts often fail relatively early in @entity1 . We analyzed the incidence of @entity340 and @entity1031 in 253 consecutive adult survivors who received 294 porcine xenograft valves (150 aortic, 125 mitral and 19 tricuspid) from June 1974 to December 1979 (41% of all adult valve replacements). Mean follow-up was 25.6 months (range 9-75 months). @entity340 occurred in four of 294 xenografts (three in mitral position and one in tricuspid position), all four caused by recurrent @entity884 ; these four @entity1 survived reoperation and are doing well. @entity1031 occurred in six of 294 xenografts, none in aortic or tricuspid positions of rhythm or anticoagulation. Four of the six mitral xenografts associated with @entity1031 were in the 16 @entity1 who had @entity955 and received @entity117 and dipyridamole but no @entity1229 (12% per @entity1 -year), and two were in the 14 @entity1 who were in sinus rhythm and were not taking medication, one of whom had recurrent @entity884 . No @entity1031 occurred in mitral xenografts with sinus rhythm and antiplatelet agents. @entity1031 did not occur in @entity1 who were in @entity955 and receiving @entity1229 anticoagulation. Late death (30 of 253) was unrelated to @entity340 , and only one death resulted from @entity1031 . This study showed excellent xenograft performance for as long as 75 months. @entity340 occurred only with recurrent @entity884 , and @entity1031 occurred after mitral replacement, especially in @entity1 who were in @entity955 and were not receiving anticoagulants.
