Decreased hyaluronidase 1 expression is associated with early disease recurrence in human XXXX .

@entity1204 @entity25896 @entity5 @entity1184 @entity5962 @entity3202 @entity3 @entity9906
OBJECTIVE: Hyaluronidases ( @entity9906 and @entity25896 ) are key enzymes in the degradation of hyaluronan, and their expression has been altered in various @entity5 types. We previously showed that hyaluronan accumulation in @entity1204 was correlated with decreased mRNA expression of the HYAL genes. In this study, we analyzed @entity9906 and @entity25896 protein expressions in normal and precancerous endometrial tissues and in @entity1204 . We also investigated whether the protein levels were associated with clinicopathological factors, invasion, and disease recurrence. METHODS: A total of 343 tissue specimens from normal, @entity3202 , @entity1184 , and neoplastic endometria were analyzed immunohistochemically for @entity9906 and @entity25896 expressions. The results were correlated with clinicopathological factors, the expression of the epithelial-mesenchymal transition marker, @entity5962 , and disease recurrence. RESULTS: Reduced @entity9906 expression was associated with the progression of @entity1204 towards higher grades and also with large @entity5 sizes, lymph node @entity3 , and @entity3 . Reduced expression of both @entity9906 and @entity25896 was associated with deep @entity3 . @entity25896 expression was primarily constant in neoplastic tissues, but its expression was altered in different phases of the endometrial cycle. In addition, a reduction in @entity9906 expression was associated with the depletion of @entity5962 . In a multivariate analysis, reduced @entity9906 expression was an independent prognostic factor for early disease recurrence (HR 5.13, 95% CI: 1.131-23.270, p=0.034). CONCLUSIONS: This study showed that reduced @entity9906 expression was associated with @entity1204 , which further supported the role of hyaluronan degradation in @entity5 progression.
