Learning and memory is preserved after induced asanguineous @entity1167 in a XXXX model of traumatic exsanguination.

@entity1 @entity1707 @entity2332 @entity548 @entity1167 @entity1317 @entity6564 @entity130
BACKGROUND: Induced @entity1167 (suspended animation) could provide valuable time to repair major @entity1317 if safely induced in @entity1 with @entity130 . We report a novel method of doing this in a @entity1707 model of uncontrolled lethal @entity548 (ULH) that resulted in preservation of learning ability and memory. METHODS: Yorkshire @entity1707 (100 to 125 lb) underwent ULH before rapid intra-aortic infusion of a hypothermic (4 degrees C), @entity6564 (70 mEq/L) organ preservation solution by a left thoracotomy. Cooling continued until core temperature reached 10 degrees C, and this was maintained for 60 minutes using low-flow cardiopulmonary bypass. @entity1317 were repaired during this state of suspended animation, which was then reversed, and the animals were observed for 6 weeks. Cognitive functions were tested by training animals to retrieve food from color-coded boxes. Postoperatively, the ability to remember this task and a 75-point objective neurologic scale were used to test neurologic function. In experiment I, ULH was caused by lacerating thoracic aorta (n = 9). Five preoperatively untrained animals were trained to perform the task and compared with control animals (n = 15), and 4 preoperatively trained animals were tested for memory retention postoperatively. In experiment II, ULH was induced by creating an iliac artery and @entity130 (n = 15). Animals were kept in shock for 15, 30, and 60 minutes before the induction of @entity2332 . RESULTS: In experiment I, surviving animals (7/9) were neurologically intact, and their capacity to learn new skills was no different than for control animals. All pretrained animals demonstrated complete memory retention. In experiment II, survival with 15, 30, and 60 minutes of shock were 80%, 60%, and 80%, respectively. All animals (except 1) in the 60-minute group were neurologically intact and displayed normal learning capacity. CONCLUSIONS: Induction of hypothermic @entity1167 (by thoracotomy) for repair of complex @entity130 is feasible with preservation of normal neurologic function, even after extended periods of shock from an intra-abdominal source of uncontrolled @entity548 .
