Is the logopenic-variant of primary progressive XXXX a unitary disorder?

@entity1 @entity51 @entity2026 @entity194 @entity2414 @entity5547
UNASSIGNED: Logopenic progressive @entity2026 is one of the clinical presentations of primary progressive @entity2026 and formally defined by the co-occurrence of impaired naming and sentence repetition. Impaired naming is attributed to failure of lexical retrieval, which is a multi-staged process subserved by anatomically segregated brain regions. By dissecting the neurocognitive processes involved in impaired naming, we aimed to disentangle the clinical and neuroanatomical heterogeneity of this syndrome. Twenty-one individuals (66.7% females, age range 53-83 years) who fulfilled diagnostic criteria for logopenic variant and had at least two clinical and language assessments, 1 year apart, were recruited and matched for age, sex distribution and level of education with a healthy control sample (n  =  18). All @entity1 underwent a structural brain scan at the first visit and surface-wise statistical analysis using Freesurfer. Seventeen @entity1 with logopenic variant underwent amyloid imaging, with 14 demonstrating high amyloid retention. Based on their performance on single-word comprehension, repetition and confrontation naming, three subgroups of logopenic cases with distinctive linguistic profiles and distribution of @entity194 were identified. The first subgroup (n  =  10) demonstrated @entity5547 and left-sided @entity194 in the posterior inferior parietal lobule and lateral temporal cortex. The second subgroup (n  =  6), presented additional mild @entity51 , and also exhibited bilateral thinning of the fusiform gyri. The third subgroup (n  =  5) showed additional @entity2414 , and cortical thinning focused on the left superior temporal gyrus. The subgroups differed in the proportion of cases with high amyloid retention and in the rate of decline of naming performance over time, suggesting that neurodegeneration spreads differentially throughout regions subserving word processing. In line with previous reports, these results confirm the extensive damage to the language network and, in part, explain the clinical heterogeneity observed across logopenic cases.
