Assessment of sarcoplasmic reticulum @entity141 -uptake during the development of XXXX .

@entity712 @entity35 @entity1184 @entity3386 @entity891 @entity4346 @entity141
Cardiac sarcoplasmic reticulum (SR) sequesters @entity141 and plays a crucial role in the regulation of intracellular @entity141 . Its functional properties are central to the excitation-contraction cycle of cardiac muscle. In this study, we hypothesized that alterations in SR function occur during the development of left ventricular (LV) @entity1184 . @entity4346 was produced in Lewis @entity35 by the one-kidney, one-clip (1K1C) procedure. LV tissues were obtained from 1K1C @entity35 1 week (mild, N=7), 4 weeks (moderate, N=7), and 8 weeks (severe, N=7) post-surgery and from the corresponding age-matched, sham-operated controls (N=7 at each stage). In all of these @entity35 , the ratio of LV weight (g) to body weight (kg) was determined and considered as an index for @entity4346 . In addition, the ratio of lung weight (g) to body weight (kg) was determined and considered as an index for @entity891 and @entity712 . In each LV specimen, SR @entity141 -uptake and tissue @entity141 -ATPase ( @entity3386 ) level were determined. In 1K1C @entity35 , @entity4346 increased by 21, 40, and 90% at 1, 4, and 8 weeks post-surgery, respectively, compared to the age-matched, sham-operated @entity35 , whereas @entity891 did not occur at 1 and 4 weeks but increased significantly by about 21% at 8 weeks. Further, both SR @entity141 -uptake and immunodetectable @entity3386 level did not change at 1 week, increased (54%) to the same extent at 4 weeks, and decreased (42%) by approximately the same extent at 8 weeks in 1K1C @entity35 compared to the age-matched, sham-operated @entity35 . In summary, as @entity4346 evolved, @entity141 -uptake and @entity3386 expression did not change in the early, increased in the moderate, and then declined in the later stages of @entity1184 development. The increase in @entity141 -uptake and @entity3386 expression suggests, at the cellular level, a compensatory response to @entity4346 , while the decline at later stages indicates the transition to @entity712 .
