Urokinase induces @entity1570 expression in @entity1 XXXX cells.

@entity1 @entity10431 @entity1570 @entity3 @entity3419 @entity157 @entity2290
Both the @entity2290 ( @entity2290 ) and the @entity10431 ( @entity10431 ) play important roles with @entity157 ( @entity157 ) progression and @entity3 . Notably, the @entity1570 ( @entity1570 ) is an important chemokine involved in @entity157 pathology. However, the influence of @entity2290 on @entity1570 expression in @entity1 @entity157 cells remains unknown. We investigated the mechanisms underlying the modulation of @entity1570 expression through @entity2290 stimulation in @entity1 @entity157 SK-Hep-1 cells. SK-Hep-1 cells stimulation with @entity2290 induced increases in the expression and secretion of @entity1570 . By using specific inhibitors and small interfering RNA, we have demonstrated that the activation of extracellular signal-related kinase (ERK) and c-Jun-NH(2)-terminal kinase (JNK) pathways are critical for @entity2290 -induced @entity1570 expression. Transcription factor ELISA and chromatin immunoprecipitation assays suggest that @entity2290 increase @entity3419 - and AP-1-DNA-binding activities in SK-Hep-1 cells. Inhibition of @entity3419 and AP-1 activations by specific siRNAs blocked the @entity2290 -induced @entity1570 promoter activity and expression. The effect of @entity2290 on SK-Hep-1 signaling and @entity1570 expression is mediated by @entity10431 . In summary, our findings serve to elucidate the @entity2290 / @entity10431 downstream signaling, providing new insight into the function of @entity2290 in @entity157 cells.
