The @entity2100 protein interacts with novel homologs @entity38038 and XXXX .

@entity1 @entity1032 @entity72045 @entity38038 @entity2100 @entity10308
@entity2100 is the most common form of @entity1032 , and is caused by defects in the @entity10308 gene. @entity10308 is an RNA-binding protein and the syndrome results from lack of expression of @entity10308 or expression of a mutant protein that is impaired in RNA binding. The specific function of @entity10308 is not known. As a step towards understanding the function of @entity10308 we searched for proteins that interact with it in vivo. We have cloned and sequenced a protein that interacts tightly with @entity10308 in vivo and in vitro. This novel protein, @entity72045 , is very similar to @entity10308 (60% identity). @entity72045 encodes a 74 kDa protein which, like @entity10308 , contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The @entity72045 gene is located on @entity1 chromosome 17 at 17p13.1. In addition, @entity10308 and @entity72045 interact tightly with the recently described autosomal homolog @entity38038 . Each of these three proteins is capable of forming heteromers with the others, and each can also form homomers. @entity38038 and @entity72045 are thus likely to play important roles in the function of @entity10308 and in the pathogenesis of the @entity2100 .
