Proliferation rate and XXXX subtype, but not @entity14215 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced @entity0 .

@entity1 @entity0 @entity5 @entity14215 @entity1722
UNASSIGNED: For locally advanced @entity0 , pathological complete response (pCR) following neoadjuvant chemotherapy (NACT) is associated with good disease-free survival. In several studies, response to chemotherapy according to various parameters has shown strong inter-individual variability. We investigated whether different prognostic factors, including @entity14215 expression, might predict response to NACT in female @entity1 with locally advanced @entity0 . ER, PR, @entity1722 , Ki-67 and @entity14215 immunohistochemistry were performed on the initial biopsy and subsequent resection specimens. @entity5 burden was calculated in post NACT resection specimens using @entity5 ( @entity5 ) protocol. Of our cohort of 66 @entity1 , 24 (36  %) achieved pCR. Triple negative phenotype and high Ki-67 proliferative index (>40  %) were significantly associated with good response to NACT. @entity14215 expression in @entity5 epithelial (20  %) or stromal (44  %) cells did not correlate with @entity5 grade, molecular subtype, proliferative index or NACT response. However, epithelial and stromal @entity14215 expression was significantly increased in @entity5 after NACT. In conclusion, triple negative phenotype and high proliferative index, but not @entity14215 expression, are predictive of good pathological response to NACT. Increased @entity14215 expression following NACT might be associated with a higher probability of recurrent disease.
