[VNTR3' polymorphism of apoliproprotein B gene in XXXX @entity1 ].

@entity1 @entity2975 @entity28 @entity755
@entity755 (apo B) is the major component of LDL, VLDL and chylomicrons. Variations of lipid concentrations in @entity28 @entity1 result from @entity28 , nutritional and genetic factors. Many genetic polymorphisms of the apo B have been described, associated with variation of lipid concentrations. The aim of the present study was to assess the effect of VNTR3' polymorphism of the @entity755 gene on lipid and lipoprotein concentrations in overweight subjects. 234 unrelated outpatients (160 @entity1 and 74 @entity1 , aged 39.3 y 10.5; BMI: 32.8 kg/m2 4.7) were recruited. Using the polymerase chain reaction followed by electrophoresis in @entity2975 gels, 15 different alleles have been identified. Among them four have been observed less than 5 times in our study. Alleles with 21, 25, 35 and 42 repeats have been observed once. The most frequent is VNTR36 allele (38%), followed by alleles 34, 30, 48, and 46 repeats whose frequencies are 20, 9, 8, and 7% respectively. The possible association between alleles of the VNTR3' of the @entity755 and anthroprometric and lipid variables was examined. Subjects with 50 repeat allele had significantly higher BMI, and subjects with 32 repeat allele had significantly higher HDL-C and ApoAI levels. Our study confirms in the @entity28 subjects, results published in the general litterature, and shows that the @entity755 has an important role in the metabolism of plasma lipids and most particulary its gene variants.
