Should salvage surgery be considered for local recurrence after definitive chemoradiation in locally advanced XXXX ?

@entity1 @entity1149 @entity204 @entity5
BACKGROUND: Incidence of local relapse after definitive chemoradiation (>59  Gy) for locally advanced @entity1149 ( @entity1149 ) is high, irrespective of high dose radiation applied. Experience with salvage lung resections in @entity1 with locally relapsed @entity1149 after definitive chemoradiation is limited. We present our series of salvage lung resections for local @entity1149 relapse after curative-intent chemoradiation for locally advanced @entity5 . METHODS: Nine consecutive @entity1 with local @entity5 recurrence or persistence following definitive chemoradiation were reviewed. Kaplan-Meier analysis was used to assess @entity1 survival. RESULTS: All @entity1 received definitive radiation (median dose 66.2  Gy) with concurrent chemotherapy. @entity5 stage prior to chemoradiation was IIIA in 8 @entity1 and IV in 1. In 4 @entity1 @entity5 invaded the chest wall, in 2 the spine and in 1 the aorta. Median interval between chemoradiation and salvage resection was 30.2  weeks. Nine @entity1 underwent 9 resections (6 lobectomies, 1 bilobectomy, 1 pneumonectomy and 1 bi-segmentectomy). One @entity204 occurred on the 12th postoperative day. Median overall survival was 23  months; postoperative 3-year survival was 47  %. Median progression-free survival was 21  months. CONCLUSION: Salvage lung resection for locally recurrent or persisted @entity1149 in selected @entity1 with locally advanced @entity1149 following definitive chemoradiation is a worthwhile treatment option.
