Evaluation of the local effects of @entity270 (E-Mousse) on free radicals in XXXX : a randomized, controlled trial.

@entity1 @entity2175 @entity1095 @entity270 @entity6 @entity532
The aims of the study were to evaluate the short-term effects of a new thermosensitive, @entity270 (V-E) mousse on local free radicals (FR) and skin flux in @entity532 . A group of 40 @entity1 with @entity532 was included. The variation in measurements of skin FR was evaluated by the D-Rom test. Subjects were between 45 and 65 years with @entity2175 and good metabolic control. E-mousse, a thermoactive preparation of acetate @entity270 (20%), was applied twice daily on the whole surface of the leg (below knee) and foot for 3 weeks. The contralateral leg was untreated acting as control. Subjects with age between 45 and 65 years with @entity2175 (diagnosed at least 5 years before) and good metabolic control (blood sugar < 180 mg/dL) were included after informed consent. @entity1 with uncontrolled @entity6 , @entity1095 , and severe lower limbs infections were excluded. Local free radicals (FR) and laser Doppler flux including the venoarteriolar response (VAR) were evaluated. The tolerability was evaluated by a semiquantitative score. Of the 40 included @entity1 34 completed the study. The 2 groups were comparable. At 3 weeks there was no decrease in FR in controls; the decrease in the treatment group was 45.3% (p < 0.05). Also in the treatment group RF decreased (p < 0.05) and the VARveno improved from an average of 21% to an average of 38% (p < 0.05). No significant variations were observed in the control group. The variation in symptomatic score was from a total value of 8 to 5 in the control group and from 8 to 1 in the treatment group (p < 0.02). Their tolerability was good. In conclusion local treatment with E-mousse for 3 weeks in @entity532 improves skin microcirculation and the metabolic condition as shown by the decrease in FR.
