Impact of Bleeding on Quality of Life in XXXX on DAPT: Insights From TRANSLATE-ACS.

@entity1 @entity548 @entity63 @entity73 @entity148 @entity158 @entity583 @entity7634
BACKGROUND: Prolonged dual antiplatelet therapy (DAPT) is recommended after an @entity583 ( @entity583 ) to reduce @entity63 events but is associated with increased rates of major and @entity548 . OBJECTIVES: This study sought to determine the incidence of post-percutaneous coronary intervention (PCI) @entity548 that occurs on contemporary DAPT and its impact on quality of life (QOL). METHODS: We studied 9,290 @entity583 @entity1 treated with PCI and discharged alive between April 2010 and September 2012. Post-discharge @entity548 was categorized according to the Bleeding Academic Research Consortium (BARC) definition. The primary outcome was the 6-month @entity7634 QOL-5 Dimension (EQ-5D) index score (a measure of health utility); a secondary outcome was the EQ-5D visual analog scale (VAS) at 6 months. RESULTS: Of the 9,290 @entity1 with @entity583 , @entity548 events occurred as follows: any BARC @entity548 : 24.2%; BARC 1: 9.1%; BARC 2: 13.8%; BARC 3: 1.1%; BARC 4: 0.03%; and BARC 5: 0%. Those who experienced any BARC @entity548 had lower scores across all 5 EQ-5D domains (mobility, self-care, usual activities, @entity158 , and @entity148 ), as well as lower EQ-5D VAS and EQ-5D index scores. After clinical risk adjustment, any BARC @entity548 was independently associated with 6-month EQ-5D index score (p  < 0.0001) and lower QOL (p  < 0.001). Both the EQ-5D index and the VAS score declined in a stepwise fashion with increasing BARC severity. CONCLUSIONS: Among @entity1 undergoing PCI for @entity583 , @entity548 during follow-up was associated with worse 6-month utility and QOL. Although even @entity548 was associated with @entity73 status and QOL, the degree of impairment increased in a stepwise fashion with @entity548 severity.
