Effect of @entity1421 on rib XXXX healing in beagles: histomorphometric study on periosteum adjacent to the @entity174 site.

@entity174 @entity235 @entity1421 @entity5385 @entity3009 @entity1068
A histomorphometric study was done on healing defects in the ribs of Beagles. A transverse @entity174 was made in the left 9th and 10th ribs. Beagles were given either @entity1068 vehicle (n = 6) or @entity3009 (PG) E2 orally (n = 5) for the 30-day period after surgical manipulation to time of necropsy. Double fluorescent labels to measure bone matrix mineralization were given with each of 2 fluorochrome markers--calcein before @entity235 were surgically manipulated and @entity5385 before they were euthanatized. The objectives were to determine the effects of @entity174 on regional remodeling in the periosteum, the effects of @entity1421 on the regional remodeling changes in the periosteum induced by the @entity174 , and the systemic effect of @entity1421 on remodeling changes of the contralateral matching sites. The @entity174 in the nontreated @entity235 ( @entity1068 only) stimulated remodeling activity in the periosteum with increased resorption (P less than 0.01). However, after surgical manipulation (necropsy) was done, the extent of mineralization on the bone surface was decreased and was decreased more on the nonfractured ribs (right side) than on the fractured (healing) ribs (left side) (P less than 0.05). In the treated @entity235 , the administration of @entity1421 increased the extent of mineralization on the bone surface on the healing ribs. However, as in the nontreated @entity235 , the administration of @entity1421 did not alter the decreasing pattern of mineralization when comparing the bone surfaces at necropsy with the bone surfaces before surgical manipulation was done.(ABSTRACT TRUNCATED AT 250 WORDS)
