Differentiation of ductal carcinoma in-situ from benign micro- XXXX by dedicated breast computed tomography.

@entity730 @entity3918 @entity1 @entity3821
PURPOSE: Compare conspicuity of @entity3821 ( @entity3821 ) to benign @entity730 on unenhanced (bCT), contrast-enhanced dedicated breast CT (CEbCT) and mammography ( @entity3918 ). METHODS AND MATERIALS: The institutional review board approved this HIPAA-compliant study. 42 @entity1 with Breast Imaging Reporting and Data System 4 or 5 category micro- @entity730 had breast CT before biopsy. Three subjects with invasive disease at surgery were excluded. Two breast radiologists independently compared lesion conspicuity scores (CS) for CEbCT, to bCT and @entity3918 . Enhancement was measured in Hounsfield units (HU). Mean CS  standard deviations are shown. Receiver operating characteristic analysis (ROC) measured radiologists' discrimination performance by comparing CS to enhancement alone. Statistical measurements were made using ANOVA F-test, Wilcoxon rank-sum test and robust linear regression analyses. RESULTS: 39 lesions (17 @entity3821 , 22 benign) were analyzed. @entity3821 (8.5  0.9, n=17) was more conspicuous than benign micro- @entity730 (3.6  2.9, n=22; p<0.0001) on CEbCT. @entity3821 was equally conspicuous on CEbCT and @entity3918 (8.5  0.9, 8.7  0.8, n=17; p=0.85) and more conspicuous when compared to bCT (5.3  2.6, n=17; p<0.001). All @entity3821 enhanced; mean enhancement (90HU  53HU, n=17) was higher compared to benign lesions (33  30HU, n=22) (p<0.0001). ROC analysis of the radiologists' CS showed high discrimination performance (AUC=0.94) compared to enhancement alone (AUC=0.85) (p<0.026). CONCLUSION: @entity3821 is more conspicuous than benign micro- @entity730 on CEbCT. @entity3821 visualization on CEbCT is equal to mammography but improved compared to bCT. Radiologists' discrimination performance using CEBCT is significantly higher than enhancement values alone. CEbCT may have an advantage over mammography by reducing false positive examinations when @entity730 are analyzed.
