Association between genes encoding components of the Leutinizing hormone/Luteinizing hormone-choriogonadotrophin receptor pathway and @entity3610 in Egyptian XXXX .

@entity1 @entity3610 @entity57962 @entity28 @entity72935 @entity6753 @entity72936 @entity209 @entity10548
UNASSIGNED: @entity3610 ( @entity3610 ) is one of the most common @entity209 ; however, its pathophysiology is still unclear. Certain polymorphisms of @entity6753 ( @entity6753 ) and @entity10548 ( @entity10548 ) genes may lead to changes in the bioactivity of this hormone. We aimed to investigate possible associations between polymorphisms in the @entity6753 and @entity10548 genes and @entity3610 among Egyptian @entity1 . We also aimed to shed light on the impact of these polymorphisms on LH level, hormonal, and metabolic features of @entity3610 . A case-control study included unrelated 210 @entity1 with @entity3610 and 200 healthy controls, and they were stratified according to their body mass index into two subgroups: lean and @entity28 . Polymorphisms of @entity6753 @entity57962 and @entity10548 [ @entity72935 , and ins18LQ] genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Our results revealed that @entity6753 @entity72936 GA genotype and A allele, @entity10548 @entity72935 GA, AA genotypes, or A allele were significantly associated with @entity3610 risk, while the @entity10548 ins18LQ polymorphism was not. Additionally, there is a synergism between @entity6753 @entity72936 minor A and minor A allele of @entity10548 @entity72935 or minor ins allele of @entity10548 ins18LQ and susceptibility to @entity3610 . When we stratified @entity3610 @entity1 or controls into @entity28 and lean subjects, we found that @entity6753 @entity57962 GA genotype and A allele being more frequent in the @entity28 group when compared with lean @entity1 with @entity3610 [The odds ratio and 95% confidence interval were 5.6 (1.30-24.56) and 5.15 (1.21-21.90), respectively, P   =   0.01, for each group.] These results suggested that @entity6753 @entity72936 and @entity10548 @entity72935 genes polymorphisms are associated with increased risk of @entity3610 in Egyptian @entity1 especially in @entity28 cases. There was a synergism between @entity6753 @entity72936 minor A allele and of @entity10548 @entity72935 minor A or minor ins alleles of @entity10548 ins18LQ and @entity3610 risk.    2015 IUBMB Life, 2015.
