Hippocampal NMDAR-Wnt-Catenin signaling disrupted with XXXX in adolescent offspring exposed to prenatal @entity519 .

@entity4319 @entity73 @entity26 @entity3391 @entity4476 @entity4474 @entity6035 @entity50589 @entity51 @entity519 @entity35
UNASSIGNED: Prenatal @entity519 (PH) is one of the most common stresses on fetuses, and might lead to abnormal brain development. This work investigates whether PH affects behavioral development of the learning/memory ability in the adolescent offspring @entity35 and the underlying molecular basis in the brain. In this study, pregnant @entity35 used to generate PH offspring were treated with @entity519 (10.5% @entity26 ) from gestational day 4 to 21. Brain weights of either the fetuses or the 6-week old offspring in the PH group were found to be significantly lower compared with the control group. Morris water maze tests showed longer escape latency and swimming distance during navigation testing in the PH offspring; Retention tests demonstrated less frequency of crossing target areas indicating @entity73 in the PH offspring. The expressions of subunits of @entity3391 receptors (NMDARs), @entity4474 / @entity4474 , @entity4476 / @entity4476 , and @entity4319 / @entity4319 , were significantly decreased in the hippocampus of adolescent offspring in the PH group. @entity6035 as well as active form of b-catenin protein were also significantly down-regulated. Furthermore, the expression of early response gene, @entity50589 , was significantly reduced. The results above provide new evidence that PH might result in the spatial acquisition and @entity51 in the adolescent offspring, associated with dysregulation of NMDARs-Wnt-Catenin signaling in the hippocampus. This study result deepens the knowledge of the long-term influence of prenatal insults on the neuro-behavioral development.
