@entity1778 and myelodysplasia in XXXX . Report of a case and results of morphologic, cytogenetic, and bone marrow culture studies in long-term survivors.

@entity1 @entity2214 @entity2007 @entity417 @entity882 @entity3052 @entity1778 @entity151
The bone marrow of 11 @entity1 with @entity151 , who survived more than two years following combined-modality therapy, was subjected to morphologic, cytogenetic, and bone marrow culture studies. One @entity1 , after a prodrome of @entity417 and @entity882 , developed @entity3052 60 months after the start of chemotherapy. Four months @entity1778 developed, bone marrow culture studies showed a marked inability to form colonies. Cytogenetic studies demonstrated an abnormal clone of cells that included the deletion of the long arm of chromosome 5. No morphologic abnormalities were noted in the bone marrow of any other long-term survivor; however, the mean corpuscular volume of peripheral red blood cells was greater than normal in three of four @entity1 who remain alive and disease free. In one of these @entity1 marrow culture studies also failed to grow colonies. The other @entity1 showed a decreased ability to form multilineage colonies and colonies of the granulocyte-macrophage lineage in vitro compared with a control population. All @entity1 showed some degree of @entity2007 on cytogenetic analysis; in two cases approximately 50% of cells were aneuploid. However, no @entity2214 was detected in any @entity1 . Follow-up for the development of secondary @entity3052 and other long-term complications continues in these @entity1 .
