Lack of association of @entity1495 promoter gene polymorphism in obstructive XXXX .

@entity1 @entity32 @entity387 @entity27 @entity15606 @entity1495
PURPOSE: @entity27 ( @entity27 ) is a public health problem. There is an effort to establish the genetic contributions to the development of @entity27 . One is matrix metalloproteinases, extracellular matrix degrading enzymes related to systemic @entity32 . However, the impact of @entity1495 ( @entity1495 ) genotypes on the development of @entity27 is unknown. Our aim was to determine whether @entity1495 single nucleotide polymorphism (SNP) ( @entity1495 @entity15606 ) is related to susceptibility to @entity27 . MATERIAL AND METHODS: A total of 106 @entity1 with a history of @entity387 and 88 controls without a history of @entity387 were enrolled in this study. Genotypes were determined by restriction fragment length polymorphism analyses after polymerase chain reaction. RESULTS: Genotypes and allele frequencies of the @entity1495 @entity15606 SNP was not statistically different between the @entity1 and control groups (p  >  0.05). There was a statistical association between @entity27 index (AHI) and body mass index (BMI), and also between AHI and neck circumference (p  <  0.001). There was no association among the genotypes and AHI, neck circumference, or BMI (p  >  0.05). CONCLUSIONS: We found no association between @entity1495 @entity15606 SNP and @entity27 . Studies to investigate the role of other polymorphisms and expression of @entity1495 gene will provide more information.
