Complementary Roles of @entity957 Antigen and (18)F-FDG PET/CT in Suspected Recurrence of XXXX .

@entity1 @entity5 @entity957 @entity2286 @entity1544
PURPOSE: To assess the clinical value of FDG PET/CT and evaluate the complementary roles of serum squamous cell carcinoma antigen (SCCAg) and FDG PET/CT in the diagnosis of suspected recurrent of cervical @entity1544 . METHODS: Serum SCCAg levels were retrospectively reviewed in @entity1 previously treated for @entity957 , who had suspected recurrence of cervical @entity5 and who had undergone FDG PET/CT scans. The clinical impact of elevated SCCAg (>1.5 ng/ml) and negative SCCAg ( <=1.5 ng/ml) levels were analyzed based on the results of PET/CT and final diagnosis. RESULTS: The overall @entity1 -based sensitivity, specificity, accuracy, positive predictive value ( @entity2286 ) and negative predictive value (NPV) of PET/CT for the detection of @entity5 recurrence or @entity5 were 100% (86/86), 80.8% (21/26), 95.5% (107/112), 94.5% (86/91) and 100% (21/21), respectively. Of the 112 @entity1 included in this study, recurrence or @entity5 was detected by PET/CT in 62 of the 64 @entity1 with elevated SCCAg, compared to 24 of the 48 @entity1 with negative SCCAg levels. The overall @entity1 -based @entity2286 , NPV, sensitivity and accuracy of SCCAg for the detection of @entity5 recurrence or @entity5 were 96.9% (62/64), 50% (24/48), 72.1% (62/86) and 76.8% (86/112), respectively. The five false-positive PET/CT results were all associated with @entity1 with negative SCCAg levels. The @entity2286 of positive PET/CT-associated elevated SCCAg for the detection of @entity5 recurrence or @entity5 was 100% (62/62). The NPV of negative SCCAg-associated negative PET/CT was 100% (19/19). CONCLUSIONS: Serum SCCAg evaluation and FDG PET/CT imaging can be complementary techniques in cases of suspected recurrent cervical @entity5 . Positive PET/CT with elevated SCCAg can predict recurrence. Although PET/CT cannot confidently be deferred due to a negative SCCAg test, the possibility of a false-positive PET/CT in those cases may have diagnostic importance.
