Immune @entity882 in XXXX .

@entity1 @entity295 @entity882 @entity2348 @entity5642 @entity281 @entity1800
@entity882 occurs frequently in newborn @entity1 with @entity295 , but the exact mechanism remains obscure in those @entity1 who do not have evidence of disseminated @entity5642 . Since recent work has suggested a possible immune mechanism for @entity882 observed in adults with @entity295 , we have investigated the role of platelet-associated immunoglobulin in @entity281 . To detect PAIgG we use a method employing protein A and peroxidase-antiperoxidase as a labeled antibody. PAIgG was quantitated by phase contrast microscopy and expressed as a reactive index. Our control group included 16 normal newborn @entity1 whose mean RI was 0.65 +/- 0.01 SE. In addition to the control group, five @entity1 with nonimmune @entity882 were included; their mean RI was 0.66 +/- 0.01 SE. Seventeen newborn @entity1 with severe @entity281 were assayed for PAIgG. Eight of nine @entity1 with @entity2348 had increased RI, with a mean of 1.16 +/- 0.03 SE (P less than 0.01). Six of the eight @entity1 with @entity1800 had elevated RI, with a mean of 1.23 +/- 0.03 SE (P less than 0.01). These findings suggest that an immune mechanism may be involved in the @entity882 of severe @entity281 .
