XXXX involvement in social behavior in rodents: Rapid and long-term actions.

@entity172 @entity1782 @entity146 @entity53 @entity1783 @entity21841
This article is part of a Special Issue (" @entity53 and cognition"). @entity172 have repeatedly been shown to influence a wide array of @entity146 , which in rodents are predominantly olfactory-mediated. @entity172 are involved in social behavior at multiple levels of processing, from the detection and integration of socially relevant olfactory information to more complex @entity146 , including social preferences, aggression and dominance, and learning and memory for social stimuli (e.g. social recognition and social learning). Three @entity172 receptors (ERs), @entity1782 , @entity1783 , and the @entity21841 ( @entity21841 ), differently affect these behaviors. Social recognition, @entity146 , and sexual preferences and mate choice, all requiring the integration of socially related olfactory information, seem to primarily involve @entity1782 , with @entity1783 playing a lesser, modulatory role. In contrast, social learning consistently responds differently to @entity172 manipulations than other @entity146 . This suggests differential ER involvement in brain regions important for specific @entity146 , such as the ventromedial and medial preoptic nuclei of the hypothalamus in social preferences and aggression, the medial amygdala and hippocampus in social recognition, and the prefrontal cortex and hippocampus in social learning. While the long-term effects of @entity1782 and @entity1783 on social behavior have been extensively investigated, our knowledge of the rapid, non-genomic, effects of @entity172 is more limited and suggests that they may mediate some @entity146 (e.g. social learning) differently from long-term effects. Further research is required to compare ER involvement in regulating social behavior in male and female animals, and to further elucidate the roles of the more recently described G protein-coupled ERs, both the @entity21841 and the Gq-mER.
