Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for XXXX Prevention.

@entity2736 @entity3352 @entity5018 @entity35
UNASSIGNED: Oral nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed for @entity2736 prophylaxis following at-risk injuries and procedures. We hypothesized that NSAIDs may be delivered locally in a wound for @entity2736 prophylaxis. In in vitro work, we cultured osteoblasts with three commercially available NSAIDs and then measured cell viability and DNA content. @entity3352 caused a 50% decrease in DNA at the lowest dose (0.0001 mM) and the most potent decrease in cell viability (<10% of control at 0.0005 mM). Ketorolac and @entity5018 required 10 times the dose to achieve a comparable decrease (<20% of control at 0.005 mM). In an animal study, 20 @entity35 per treatment group received a full-thickness wound dressed with either saline-moistened gauze, saline-moistened chitosan sponge, or chitosan sponge loaded with @entity3352 . After 28 days, we examined the tissue for healing. Wounds exposed to @entity3352 loaded sponges demonstrated fewer inflammatory cells. All 20 @entity35 in the @entity3352 group had complete epithelial coverage at 28 days. Eighteen (90%) wounds in the saline-chitosan group and 11 (55%) wounds in the saline-gauze group were healed. Locally delivered NSAIDs may be useful for @entity2736 prophylaxis due to effects on osteoblast viability and lack of negative effects on wound healing. Clin Trans Sci 2015; Volume #: 1-3.
