Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical @entity1745 in spinal XXXX @entity19 .

@entity19 @entity4 @entity1745 @entity17505 @entity528 @entity22262
STUDY DESIGN: Immunohistochemical examination of the expression and localization of neurofilament (NF) proteins and @entity22262 in spinal @entity17505 (twy/twy) @entity19 with progressive compression of the cervical spinal cord. OBJECTIVE: To determine the biologic functions of NF proteins and @entity22262 in the @entity19 cervical spinal cord during chronic mechanical compression. SUMMARY OF BACKGROUND DATA: The pathologic and repair process in the chronically compressed spinal cord are understood poorly. The present authors hypothesized that there existed an increased expression of NF proteins and @entity22262 in twy/twy @entity19 during the lengthy period of @entity1745 , which resembles @entity1745 . METHODS: The cervical spinal cords of 54 twy @entity19 (aged 8 weeks [n = 18], 14 weeks [n = 18], and 20 weeks [n = 18]) and 18 control animals were examined histologically. Using appropriate antibodies, sections were also stained immunohistochemically for NF proteins and @entity22262 . RESULTS: Separation of the myelin sheath from the axon and @entity4 with deformation were detected in the anterior and lateral funiculi of the spinalcords of 20-week-old twy/twy @entity19 . No such changes were noted in 8-week-old twy @entity19 . In twy/twy @entity19 aged 8 and 14 weeks with mild-to-moderate compression, weak immunoreactivities (mainly in the white matter) for NF proteins and @entity22262 were noted; however, in 20-week-old twy/twy @entity19 , these axons stained strongly positive and immunoreactive swollen axons were present. The relative area of @entity22262 immunoreactive axons gradually increased between 8 and 20 weeks in each column, particularly in the anterior and lateral funiculi in the contralateral side of compression. CONCLUSIONS: The results showed that the expression of NF proteins and @entity22262 in the white matter increased proportionally with the magnitude of @entity1745 , and indicated the possible involvement of @entity22262 in both @entity528 and repair processes in the chronically compressed spinal cord.
