STABILITY OF XXXX IN DIFFERENT TYPES OF PERITONEAL DIALYSIS SOLUTIONS.

@entity413 @entity71880 @entity9001 @entity298
UNASSIGNED:     Introduction: Intraperitoneal @entity9001 is a potential option for the treatment of @entity298 ( @entity298 )-associated @entity298 caused by microorganisms resistant to commonly used antibiotics. However, the stability of @entity9001 must be assessed in the @entity298 solution before evaluating its safety and therapeutic efficacy in @entity298 -associated @entity298 . The objective of this study was to investigate the stability of @entity9001 in 3 types of @entity298 solutions at different temperatures for various time points.     Methods: A total of 27 @entity298 bags (9 @entity298 bags for each type of @entity298 solution; 1.5% @entity413 , 7.5% icodextrin, and 1.5% @entity413 pH neutral) containing 2  g/mL of @entity9001 were prepared and stored at either 4, 25, @entity71880 . An aliquot was withdrawn immediately before (0 hour) and after pre-defined time points. Each sample was analyzed in duplicate for the concentration of @entity9001 using a stability-indicating high-performance liquid chromatography (HPLC) technique. Samples were also assessed for pH, color changes, and evidence of precipitation immediately after preparation and on each day of analysis.     Results: @entity9001 in all 3 types of @entity298 solutions retained more than 90% of its initial concentration for at least 216, 72, and 8hours at 4, 25, and 37  C, respectively. There was no evidence of precipitation at any time under the tested storage conditions. The pH and color of @entity9001 admixed @entity298 solutions stored at 4, 25, and 37  C remained essentially unchanged for 336, 96, and 48hours respectively.     Conclusion: The results obtained from the study provide a platform for future clinical studies aiming to determine the safety and therapeutic efficacy of intraperitoneally administered @entity9001 for the treatment of @entity298 -associated @entity298 .
