Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long XXXX Addition.

@entity35 @entity5928 @entity660 @entity12931
UNASSIGNED: An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related @entity660 . In this context, it has been reported that different pancreatic compartments from @entity35 were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of @entity12931 was administered life-long in @entity35 in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of @entity35 were fed normocaloric diets containing @entity12931 ( @entity5928 ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that @entity5928 supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, @entity5928 supplementation seems to improve endocrine pancreas structure and in particular b-cell mass resembling positive effects of virgin olive oil. Conversely, @entity5928 intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed @entity35 . Therefore @entity5928 may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.
