[Effect of childhood XXXX on long-term risks of @entity2998 and arterial stiffness in adulthood].

@entity1 @entity28 @entity2998 @entity731 @entity1386
OBJECTIVE: To observe the effect of childhood excessive @entity1386 on long-term risk of adult @entity2998 and arterial stiffness. METHODS: At baseline, in 1987, by using stratified cluster sampling design, 3 198 healthy @entity1 aged 6-18 were recruited from six primary schools and six middle schools from three districts (Chaoyang, Xicheng, and Haidian) in Beijing, with blood pressure, weight, height and left scapular skinfold thickness (LSSF) measured. From April 2010 to July 2012, 1 225 subjects were followed from childhood to adulthood. Questionnaire, biochemistry parameters, carotid-femoral pulse wave velocity (cfPWV), and carotid intima media thickness (cIMT) were measured at follow-up. Based on weight statuses in childhood and adulthood, subjects were classified into four groups (persistent non-overweight from childhood to adulthood, overweight in childhood but non-overweight in adulthood, non-overweight in childhood but overweight in adulthood, persistent overweight from childhood to adulthood). Multiple logistic regression model was used to analyze the association between weight statuses changing from childhood to adulthood and adult high cfPWV and high cIMT. RESULTS: The prevalence of overweight (including @entity28 ) at adulthood was 52.2% (639). Males had higher prevalence of smoking (62.5%(422/675) vs 29.4%(160/550),   (2)=133.21, P<0.001), drinking (52.1%(353/675) vs 26.1%(140/550),   (2)=87.13, P<0.001), overweight (including @entity28 ) (69.3% (468/675) vs 31.1% (171/550),   (2)=182.18, P< 0.001) than females. With adjusting for gender, age, and length of follow-up, the risk of high cfPWV and high cIMT increased by 26% and 58% for 1 units increase in BMI, and by 30% and 36% for 1 units increase in LSSF. Compared to subjects with persistent non-overweight from childhood to adulthood, subjects with overweight in childhood but non-overweight in adulthood had similar risks of high cfPWV (OR=1.59, 95%CI: 0.77-3.30)and high cIMT (OR=1.47, 95%CI:0.65-3.31). The risks of high cfPWV and high cIMT increased among subjects with non-overweight in childhood but overweight in adulthood (OR=1.92, 95%CI:1.37-2.68; OR=3.69, 95% CI:2.61- 5.23) and among subjects with persistent overweight from childhood to adulthood (OR=2.53, 95%CI:1.70-3.76; OR=5.37, 95%CI:3.62-7.97). CONCLUSIONS: We concluded that a overweight @entity1 changed to a healthy weight adult, the risks of adult subclinical @entity731 and arterial stiffness would not be increased.
