Using ordered values of subregional cartilage thickness change increases sensitivity in detecting risk factors for XXXX progression.

@entity1 @entity393 @entity2270 @entity571
OBJECTIVE: To examine whether ordered values of (sub)regional femorotibial cartilage thickness change are superior to region-based approaches in detecting risk factors for cartilage @entity393 ( @entity571 ). METHODS: 58 @entity1 with knee @entity571 had 3 Tesla MR images acquired at baseline and 24 months. Changes in cartilage thickness (   ThCtAB) were determined in eight medial femorotibial subregions. An ascending sort of individual    ThCtAB measurements was done to create "ordered values". Risk factors for @entity393 considered were: @entity2270 ( @entity2270 ), minimal (medial) joint space width (mJSW), and percent of medial tibial plateau covered by the meniscus (percent cover). All change metrics were tested for association with the risk factors using Kendall's    and relative sensitivity of multiple tests of subregions and ordered values were compared with single metrics of change from plate and compartment summaries and the first ordered value. RESULTS: The associations between subregion    ThCtAB and @entity2270 (P=0.0002), mJSW (P=0.016), and age (P=0.011) were significant, but only @entity2270 (at a=0.05) and age (at a=0.1) remained significant after adjusting for multiple subregions. In contrast, cMFTC had P-values<0.05 for @entity2270 (P=0.0001), mJSW (P=0.016), and meniscus subluxation (0.04). The first ordered value had significant associations with @entity2270 (P=0.0004), mJSW (P=0.003), meniscus subluxation (P=0.02) and percent cover (P=0.031) all of which were significant at a=0.05 after adjusting for tests on multiple risk factors. CONCLUSION: Ordered values of    ThCtAB were more sensitive in detecting risk factors of @entity393 than subregional    ThCtAB. Sensitivity was further enhanced by considering the minimum ordered value as a single test, thus not requiring adjustment for multiple tests. Using ordered values there was a significant association between    ThCtAB and baseline @entity2270 , mJSW, meniscus subluxation and meniscus percent cover. This study provides an important step in validating ordered values of cartilage change.
