Mild XXXX increases @entity1976 protein expression following global cerebral ischemia.

@entity1976 @entity1249 @entity63 @entity2310 @entity35 @entity204 @entity2332
Mild @entity2332 protects the brain against experimental @entity63 , but the reasons are not well known. We examined whether the protective effects of mild @entity2332 could be correlated with alterations in expression of @entity1976 , an anti-apoptotic protein in a @entity35 model of transient global @entity63 . Following 10 min of forebrain @entity63 , hippocampal neurons were examined 72 h later for survival, expression of @entity1976 family proteins and apoptosis. Intraischemic mild @entity2332 was applied for 3 h (33 degrees C, isch-33) or normal body temperature was maintained (37 degrees C, isch-37). Survival of @entity1249 neurons was significantly improved in the isch-33 group compared to the isch-37 group (90 vs. 53% survival; P<0.01). The proportion of @entity1976 -positive cells among surviving @entity1249 neurons in the isch-33 group was increased compared to that of sham and isch-37 groups (P<0.01). @entity2310 expression in @entity1249 was no different between sham and isch-33 groups, but was significantly decreased in isch-37 (P<0.05). TUNEL staining was positive in many isch-37 @entity1249 neurons, but absent in isch-33. Utilizing electron microscopy, more cells meeting criteria for apoptosis were observed in the isch-37 than isch-33. These data suggest that mild @entity2332 attenuates @entity204 , and that this protection may be related to increases in @entity1976 .
