Adverse testicular effects of some @entity1536 members in XXXX .

@entity13658 @entity5176 @entity73 @entity2177 @entity19184 @entity35 @entity800 @entity1536
In the last few years, a marked decrease in male fertility has been reported. Environmental factors were recently suspected for this effect. Among those factors is the misuse of drugs and in particular antibiotics. @entity5176 are a group of antibacterial agents with broad-spectrum activity. @entity73 of some @entity1536 members is controversial; a matter which stimulated our attention to investigate the adverse testicular effects of the most familiar @entity1536 members, namely: @entity800 , @entity2177 and @entity13658 . They were given to @entity35 in doses of 72, 135 and 72 mg kg(-1) day(-1) p.o., respectively, for 15 consecutive days. @entity800 was also used to establish a dose-response relationship in doses of 36, 72 and 360 mg kg(-1) day(-1) p.o. for 15 consecutive days. Results revealed that @entity800 , @entity2177 and @entity13658 reduced testicular @entity19184 activity by 39.8%, 62.7% and 60.7%, respectively. Moreover, sperm count, motility and daily sperm production were markedly decreased. @entity800 induced a dose-dependent decrease in testicular @entity19184 activity, sperm count and motility. Furthermore, daily sperm production showed a marked reduction which amounted to 26.1% and 40. 0% following administration of @entity800 (72, 360 mg kg(-1) day(-1) x 15 days), respectively. Moreover, administration of @entity800 resulted in marked testicular histopathological changes. It is concluded that, @entity800 , @entity2177 and @entity13658 significantly impaired both testicular function and structure in @entity35 .
