Chemokines, chemokine receptors and adhesion molecules on different XXXX endothelia: discriminating the tissue-specific functions that affect leucocyte migration.

@entity1 @entity32 @entity23427 @entity5737 @entity14284 @entity39 @entity5 @entity310 @entity7416 @entity5075 @entity22750 @entity2842 @entity16952 @entity379 @entity7415 @entity371 @entity687 @entity366 @entity436
The selective accumulation of different leucocyte populations during @entity32 is regulated by adhesion molecules and chemokines expressed by vascular endothelium. This study examined how chemokine production and the expression of adhesion molecules and chemokine receptors vary between endothelia from different vascular beds. @entity1 saphenous vein endothelium was compared with lung and dermal microvascular endothelia and with umbilical vein endothelium and a bone-marrow endothelial cell line. All endothelia produced @entity2842 and @entity687 constitutively, whereas @entity371 and @entity5737 were only secreted after @entity5 @entity39 factor ( @entity310 or @entity379 stimulation. In combination with @entity310 , @entity379 suppressed @entity687 but enhanced @entity5737 and @entity371 , whereas transforming growth factor (TGF)-beta reduced secretion of all chemokines. Basal chemokine secretion was higher from umbilical vein than other endothelial cells. Chemokine receptors, @entity7415 , @entity366 and @entity23427 , were present on all endothelia but highest on saphenous vein. @entity16952 , @entity5075 , @entity14284 , @entity7416 , @entity436 and @entity22750 were also detected at variable levels on different endothelia. The variation between endothelia in chemokine secretion was much greater than the variations in adhesion molecules, both on resting cells and following cytokine stimulation. These results indicate that it is the tissue-specific variations in endothelial chemokine secretion rather than variations in adhesion molecules that can explain the different patterns of @entity32 and leucocyte traffic seen in non-lymphoid tissues.
