[Investigation of multiple organ involvement in XXXX ].

@entity1 @entity8 @entity64 @entity101 @entity7791 @entity2314 @entity299 @entity9 @entity10153
OBJECTIVE: To investigate incidence and clinical features of multiple organ involvement in Chinese @entity1 with @entity2314 . METHODS: We collected 151 @entity1 of 31 families with @entity2314 , all of whom were confirmed by classic pathology, @entity7791 A activity or @entity10153 mutation from the year of 2011 to 2014 in Department of Neurology, Peking University First Hospital. The clinical data included incidence and onset of @entity9 , @entity8 , @entity299 , @entity101 and @entity64 . We calculate the incidence of these symptoms and analyze their gender difference using chi-square with SPSS 17.0 software. RESULTS: Among 31 families with @entity2314 , 151 @entity1 (82 males and 69 females) were affected, including 91 @entity1 (60.26%) with @entity9 , 62 @entity1 (41.06%) with @entity8 , 33 @entity1 (21.85%) with @entity299 , 33 @entity1 (21.85%) with @entity101 , and 21 @entity1 (13.91%) with @entity64 . The peak incidence of @entity9 was from 10 to 20 years old, followed by @entity8 from 30 to 40 years old, @entity299 and @entity64 from 40 to 50 years old. There is no peak period for @entity101 . Except for males with higher incidence of @entity8 than females (P < 0.05), there were no gender difference in the incidence of other organ involvement. CONCLUSION: The incidence and onset of multiple organ dysfunction in Chinese @entity1 with @entity2314 displayed special regularity. Gender difference appeared only in @entity8 .
