Age- and sex-related changes in the components of the hepatic microsomal mixed function oxidase system in XXXX .

@entity1447 @entity2125 @entity40444 @entity1110 @entity35 @entity9308
1. A study of the sex- and age- (4 to 103 weeks) related changes in liver microsomal mixed-function oxidase components of @entity35 , showed that total @entity1447 ranged from 12.0 to 34.0 nmol/g, peaking between weeks 26 and 39; males had higher levels than females at weeks 4 to 51. Cytochrome b5 ranged from 5.0 to 15.0 nmol/g with inconsistent age- and sex-related differences. 2. @entity1110 :cytochrome C reductase ranged from 2.6 to 4.8 mumol/min per g, with maximal activity at week 39; males had greater activity at weeks 12 to 78. @entity2125 :cytochrome C reductase ranged from 5.2 to 26.9 mumol/min per g, peaking between weeks 51 and 78; females had greater activity at weeks 12 to 51. 3. This age- and sex-related pattern of changes in these components is specific to the Sprague-Dawley strain. There are slight but significant differences between sexes only in @entity35 less than 1 year old. There was no significant correlation between rates of @entity40444 or @entity9308 metabolism and @entity1447 concentrations.
