Final height and body mass index after fractionated total body irradiation and allogeneic stem cell transplantation in XXXX .

@entity1 @entity1778
Impaired linear growth has been reported in @entity1 treated during childhood with allogeneic stem cell transplantation and fractionated total body irradiation (fTBI). The objective of this study was to determine the final height and body mass index (BMI) achieved. Forty-nine @entity1 with @entity1778 were included and surveyed for more than 5 years. Median age at follow-up was 24.3 years (range, 18.9-35.8) and median follow-up time from allograft was 14.4 years (range, 4.5-21.9). Mean height standard deviation score (s.d.s.) at final examination (-1.1    1.3,) was significantly lower than at fTBI (0.3    1.2; P = .001). Final height s.d.s. was significantly correlated with age at diagnosis, age at fTBI, and target height (P = .001; P < .001; P < .001, respectively). Final height was significantly lower in @entity1 transplanted before age 5 (P = .006). Growth hormone treatment (n = 6) had only a modest effect on growth velocity. Mean BMI at follow-up was normal at 19.6 kg/m(2) for @entity1 and 21.2 for @entity1 , but with a significant decrease since allograft only for @entity1 (-1.2    1.5 s.d.s.) (P = .003). In conclusion, final height is decreased; BMI is normal but decreased from fTBI in @entity1 .
