Decreased mortality of XXXX among carriers of @entity447 .

@entity1 @entity64 @entity548 @entity447 @entity3459 @entity299 @entity204 @entity65
BACKGROUND: Coagulation plays an important part in @entity65 . Results of studies have shown that extremes in hypocoagulability protect against @entity65 . We have investigated overall mortality and @entity204 from cardiovascular causes in carriers of @entity447 , who in most cases have mildly @entity3459 without clinical signs. METHODS: We followed-up a cohort of 1012 mothers of all known @entity1 with @entity447 in the Netherlands from birth to @entity204 , or the end-of-study date (41984 @entity1 years of follow-up). We obtained vital status and causes of @entity204 , if deceased, and compared overall and cause-specific mortality in our cohort with that in the general Dutch female population adjusted for age and calendar period by calculating the standardised mortality ratio (SMR). FINDINGS: Overall mortality was reduced by 22% (261 observed @entity204 , 333.74 expected; SMR 0.78 [95% CI 0.69-0.88]). @entity204 from @entity299 were reduced by 36% (39 observed @entity204 , 60.53 expected; SMR 0.64 [0.47-0.88]). We did not note decreased mortality for @entity64 (ischaemic and @entity548 combined) (28 observed @entity204 , 36.82 expected; SMR 0.76 [0.53-1.10]). A separate analysis of these two types of @entity64 was not possible. @entity1 in our cohort had an increased risk of @entity204 from extracranial @entity548 (5 observed @entity204 , 0.18 expected; SMR 27.78 [8.49-58.18]); however, the number of @entity204 from this cause was much lower than that for @entity299 . CONCLUSION: The results show that a mild @entity3459 has a protective effect against fatal @entity299 .
