Reduced fibrinolytic activity in XXXX in basal conditions and after exercise.

@entity1 @entity2002 @entity301 @entity1456 @entity583
Fibrinolysis may be impaired in @entity301 @entity1 . 20 @entity301 @entity1 and 10 control subjects were examined for @entity1456 activity, @entity1456 antigen, fast @entity1456 inhibitor and other fibrinolytic and haemostatic parameters including antigenic and functional protein C. Both @entity1 and control groups were similar in age and smoking habits. All of these @entity1 had a @entity583 between 1-3 months before this study. Assays were evaluated before and after an exercise test. Prothrombin time, activated partial thromboplastin time, protein C, plasminogen, alpha 2-antiplasmin, @entity2002 /fibrin degradation products and contact-activated fibrinolysis were similar before and after exercise in both groups. Fibrinolytic activity assayed by the euglobulin lysis time and fibrin-plate lysis methods was decreased in the @entity1 group as compared with the control group but the difference was not significant. In basal conditions, @entity1456 activity was defective in 50% of the @entity301 @entity1 (p less than 0.01) and after exercise this percentage rose to 77% (p less than 0.01). However, @entity1456 antigen in the @entity301 group was similar to that of the control group, both before and after exercise. The activity of the @entity1456 inhibitor was persistently increased in @entity301 though this increase was not statistically significant. It is concluded that in @entity301 @entity1 there is a defective fibrinolytic activity probably due to an increase in @entity1456 inhibitor.
