Consumption patterns and biomarkers of exposure in cigarette smokers switched to Snus, various dissolvable @entity286 products, Dual use, or XXXX abstinence.

@entity286 @entity1239 @entity20770
UNASSIGNED: The objectives of this clinical study were to evaluate changes in @entity286 product use behavior and levels of selected biomarkers of exposure (BOEs) for smokers who switched to one of six conditions during clinical confinement: exclusive use of; @entity20770 Snus, Sticks, Strips or Orbs, controlled Dual use of cigarettes and @entity20770 Snus, or @entity286 abstinence. The controlled Dual use (DU) condition mandated a 60% reduction in cigarettes smoked per day (CPD). 167 healthy U.S. male and female smokers were randomized to the six groups (n=25-30/group). Subjects smoked their usual brand of cigarette for 1day prior to switching to their designated intervention condition. Levels of thirty-two BOEs in plasma, whole blood, urine and feces were determined before and after switching. Questionnaires that scored @entity1239 dependence and withdrawal discomfort were also administered. After 5days, exclusive Snus, Sticks, Strips, or Orbs use averaged 6.1, 5.9, 13.5, and 8.5units/day, respectively. DU subjects smoked 7.6 CPD and used 3.2 Snus pouches/day, on average. After 5days, substantial reductions of most biomarkers, including @entity1239 , were observed in all groups. Toxicant exposures were similar to being @entity286 abstinent after switching exclusively to @entity20770 Snus, Sticks, Strips or Orbs. DU reductions were more modest.
