Upregulation of the @entity17782 receptor for XXXX promotes @entity1489 progression.

@entity17782 @entity3653 @entity1996 @entity19 @entity1421 @entity1489 @entity5 @entity1185 @entity189 @entity7131 @entity106 @entity7141 @entity865 @entity164 @entity864
@entity1421 ( @entity1421 ) has been shown to promote the development of @entity19 @entity1489 . @entity17782 is 1 of the 4 @entity1421 G-protein-coupled membrane receptors expressed by @entity19 keratinocytes. @entity17782 mRNA levels were increased    2-fold after topical treatment with @entity864 ( @entity865 ) or exposure to ultraviolet (UV) light, as well as increased    3- to 12-fold in @entity5 induced by @entity3653 ( @entity106 ) initiation/ @entity865 promotion or by UV exposure. To determine the effect of @entity17782 levels on @entity5 development, we generated BK5. @entity17782 @entity19 that overexpress @entity17782 in the basal layer of the epidermis. Skins of these @entity19 were histologically indistinguishable from @entity164 ( @entity164 ) @entity19 and had similar levels of proliferation after @entity865 treatment. Using a @entity106 / @entity865 carcinogenesis protocol, BK5. @entity17782 @entity19 had a reduced @entity5 multiplicity compared to @entity164 @entity19 , likely due to the observed down-regulation of @entity7131 ( @entity7131 ). However, the BK5. @entity17782 @entity19 had an    8-fold @entity1185 to @entity189 conversion rate. When @entity106 / @entity7141 was used, BK5. @entity17782 @entity19 produced more @entity5 than @entity164 @entity19 , as well as a ninefold increase in @entity189 , indicating that the @entity5 response is dependent on the type of @entity5 promoter agent used. Additionally, although almost undetectable in @entity164 @entity19 , @entity1996 ( @entity1996 ) was expressed in the untreated epidermis of BK5. @entity17782 @entity19 . While @entity865 highly induced @entity1996 in @entity164 @entity19 , @entity1996 expression in the BK5. @entity17782 @entity19 did not change after @entity865 treatment; @entity1421 levels were likewise affected. These data indicate that @entity17782 is more important in @entity5 progression than in @entity5 promotion and that it indirectly regulates @entity1996 expression.
