Determinants of Transitional Zone Area and Porosity of the Proximal Femur Quantified In Vivo in Postmenopausal XXXX .

@entity1 @entity9472 @entity174 @entity604 @entity5707
UNASSIGNED: Bone architecture as size and shape is important for bone strength and risk of @entity174 . Most @entity604 is cortical and occurs by trabecularisation of the inner part of the cortex. We therefore wanted to identify determinants of the bone architecture, especially the area and porosity of the transitional zone, an inner cortical region with a large surface/matrix volume available for intracortical @entity5707 . In 211 postmenopausal @entity1 aged 54-94 years with @entity174 and 232 controls from the Troms   Study, Norway, we quantified femoral subtrochanteric architecture in CT images using StrAx1.0 software, and serum levels of bone turnover markers (BTM). Multivariable linear and logistic regression analyses were used to quantify associations of age, weight, height, and bone size with bone architecture and BTM, and odds ratio (OR) for @entity174 . Increasing age, height and larger total cross-sectional area (TCSA) were associated with larger transitional zone @entity9472 and transitional zone @entity9472 /TCSA (standardized coefficients (STB)   =   0.11-0.80, p  <= 0.05). Increasing weight was associated with larger TCSA, but smaller transitional zone @entity9472 /TCSA and thicker cortices (STB   =   0.15-0.22, p   <   0.01). Increasing height and TCSA were associated with higher porosity of the transitional zone (STB   =   0.12-0.46, p   <   0.05). Increasing BTM were associated with larger TCSA, larger transitional zone @entity9472 /TCSA and higher porosity of each of the cortical compartments (p   <   0.01). @entity174 cases exhibited larger transitional zone @entity9472 and higher porosity than controls (p   <   0.001). Per SD increasing @entity9472 and porosity of the transitional zone, OR for @entity174 was 1.71 (95% confidence interval 1.37-2.14) and 1.51 (1.23-1.85). Cortical bone architecture is determined mainly by bone size as built during growth and is modified by lifestyle factors throughout life through bone turnover. @entity174 cases exhibited larger transitional zone area and porosity, highlighting the importance of cortical bone architecture for @entity174 propensity. This article is protected by copyright. All rights reserved.
