[Synergistic effect of cell kinetics-directed chemo-endocrine therapy on experimental mammary XXXX ].

@entity1 @entity172 @entity15353 @entity308 @entity0 @entity440 @entity5 @entity19 @entity189 @entity342
We tried to demonstrate that the cell kinetics-directed chemoendocrine therapy is more effective on hormone dependent @entity0 than empirical combination of the endocrine therapy and chemotherapy. Cell kinetics of each @entity5 was measured by flow cytometric analysis. @entity172 dependent @entity1 @entity0 cell line MCF-7 was used in vitro. In vivo, @entity342 dependent SC-115 @entity189 was transplanted to @entity15353 @entity19 . In vitro, @entity440 was administered as the endocrine therapy. In vivo, we carried out testectomy on @entity15353 @entity19 . Effect of the endocrine therapy on the cell kinetics of the @entity5 was thought to be G1-S @entity308 . High density 5FU was administered as the chemotherapeutic agents, whose content was 1 microgram/ml in vitro and 40 mg/kg in vivo. 5FU brought temporary decrease of cells in S phase. Only anteceding 5FU administration had synergistic effect in combination of 5FU and the endocrine therapy. 5FU was convinced to act more effectively on cells in S phase, so it was shown that cell kinetics-directed schedule was superior to the empirical treatment schedule in chemoendocrine therapy.
