Effects of antiepileptic drugs on concentration of serum proteins and immunoglobulins of @entity302 XXXX .

@entity1 @entity2050 @entity15068 @entity302 @entity3174 @entity8821 @entity2049
Serum of normal volunteers and serum of @entity302 @entity1 receiving either a single drug or combined antiepileptic therapy with @entity3174 ( @entity15068 ); @entity2049 ( @entity2050 ); @entity8821 (Prim); Phenobarbital (Phb) were examined and showed: No differences with regard to total proteins, albumins and A/G ratio. The alpha 1-globulin fraction increased to 4.4% with @entity15068 / @entity2050 (P less than 0.001) and decreased to 1.7% with @entity15068 /Prim = (P less than 0.001). The alpha 2-globulins corresponded to 7.2% (P less than 0.001) with @entity15068 /Prim and 15.5% (P less than 0.001) with @entity15068 /Phb treatments. beta-Globulins decreased to 7.1% (P less than 0.05) when received @entity15068 /Phb treatment. Low concentrations of serum gamma-Globulins were found in Phb (P less than 0.001), Prim (P less than 0.001, @entity15068 (P less than 0.001) treated @entity1 . However, with @entity2050 , @entity15068 /Phb, @entity15068 /Prim this electrophoretic fraction remained within the upper range of normal. IgA of @entity1 treated with @entity15068 showed a mean of 60 mg/dl. Those @entity1 with @entity15068 serum levels below or above 12-20 micrograms/ml remained normal. Prim and Phb treatment also decreased IgA. IgD was normal in @entity1 treated with @entity15068 /Prim. Alterations of immune humoral responses to all antiepileptic drugs were found.
