Tau immunohistochemistry in XXXX .

@entity1 @entity1545 @entity131 @entity542 @entity3072 @entity195 @entity528
Epidemiological studies have identified a history of @entity542 as a risk factor for @entity195 . However, the neuropathological mechanism underlying this relationship is as yet unclear. Neuronal cytoskeletal changes in the form of @entity3072 and neuropil threads have recently been demonstrated in young @entity1 who had sustained repetitive @entity542 and subsequently died in their 20s. In addition, recent experimental studies have found accumulation of @entity528 and damaged axons following diffuse @entity1545 . We hypothesized that tau-immunoreactive tangles may be present in the brains of @entity1 who died after a single acute blunt @entity542 . A total of 45 cases of fatal @entity542 were immunostained for tau. They comprised nine groups (n=5 for each group) separated by age (0-19 years, 20-50 years, 50+ years) and survival time (<24 h, 24 h-1 week, 1 week-1 month) and were compared with age-matched controls. Subtle alterations in tau immunoreactivity, for example, in oligodendrocytes, were present in some @entity542 cases but not controls. However, @entity3072 did not appear more prevalent after @entity131 ( @entity131 ) when compared with age-matched controls. Although alterations in tau immunoreactivity may occur which warrant further study, @entity3072 were not more prevalent after a single fatal episode of @entity131 .
