The role of liver biopsy in the diagnosis and prognosis of XXXX with @entity697 of @entity7160 .

@entity1 @entity697 @entity82 @entity7936 @entity281 @entity1448 @entity1850 @entity204 @entity7160 @entity528
BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity1 who require hospital admission with @entity697 of @entity7160 . METHODS: Sixty-eight @entity1 with @entity697 of @entity7160 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity528 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity1 were managed according to institutional protocols and followed until the time of hospital discharge or @entity204 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity528 was reached (r = 0.7; p = 0.0001). The presence of a @entity1850 ( @entity1850 ) suggestive of @entity7936 ( @entity7936 ), predicts severe @entity7936 histologically in only 50% @entity1 . Moreover, in 41% of @entity1850 negative @entity1 who were thought not to have @entity7936 , a diagnosis of @entity7936 was subsequently confirmed on histological grading. @entity1 that have @entity1850 criteria but no evidence of histological @entity7936 are more likely to develop @entity281 which may be indicated by the severity of canalicular @entity1448 . Nineteen @entity1 died during follow up. @entity1 manifesting @entity7936 on biopsy who were also @entity1850 positive, had a significantly greater risk of mortality compared to those that were @entity1850 positive but @entity7936 negative (p < 0.01) and those that were @entity1850 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity7936 . Early liver biopsy in these @entity1 presenting with @entity697 of @entity82 is safe and provides important diagnostic and prognostic information.
