Left ventricular mechanical support with Impella provides more ventricular unloading in XXXX than extracorporeal membrane oxygenation.

@entity1 @entity712 @entity235 @entity26 @entity519 @entity2224 @entity5707
The Impella microaxial-flow pump can directly unload left ventricle (LV) in cases of @entity712 . Extracorporeal membrane oxygenation (ECMO) is widely used for circulatory support. Although the clinical effectiveness of ECMO has been demonstrated, insufficient @entity5707 may not be advantageous for myocardial recovery. The objective was to compare ventricular loading reduction and reversibility of @entity2224 ( @entity2224 ) with either Impella or ECMO. Six @entity235 were used. Extracorporeal membrane oxygenation was established by the femoral artery and right atrium. The Impella LD was inserted in LV by the ascending aorta. An acute failing heart was created by sequential coronary artery ligations. Pressure-volume (PV) relationships were acquired without a device and with @entity519 . When @entity2224 occurred, direct cardioversion was performed while supported by either @entity519 . The PV area, which is a measure of ventricular unloading and is correlated with myocardial @entity26 consumption, decreased more with Impella than with ECMO. Successful defibrillation was achieved more effectively while under Impella support. Superior ventricular unloading with the Impella device may provide higher recovery potential to damaged hearts than ECMO and may have a significant impact not only on intensive care of @entity1 with @entity712 but also on resuscitation.
