Acute @entity6582 increases the disappearance rate of clottable fibrinogen in the newborn XXXX .

@entity6582 @entity3166 @entity101 @entity235 @entity1003
To explore the pathophysiology of the @entity3166 caused by @entity6582 in the newborn @entity235 , the effect of acute @entity6582 on fibrinogen disappearance rate was studied in 38 puppies (3-14 days). All pups received an exchange transfusion removing 65 ml/kg of blood and transfusing 85 ml/kg of either whole blood (control, resulting hematocrit = 37), or packed red blood cells ( @entity6582 , resulting hematocrit = 68). @entity3166 was found in 15 of 19 polycythemic and four of 19 control pups (p less than 0.01). 125I fibrinogen and Evan's blue (an albumin marker) were injected 2 h after transfusion and the concentration of clottable labeled fibrinogen and albumin tracer were measured at 1/2 and 2 h after injection. The fraction of the tracer that disappeared over the 1 1/2-h period was calculated. In the polycythemic group 45 +/- 18 SD% of the clottable fibrinogen disappeared versus only 28 +/- 15% in the control group (p less than 0.01). In the polycythemic group 36 +/- 21% of the albumin tracer disappeared versus 31 +/- 12% in the control group (NS). Thus @entity6582 in the newborn @entity235 is associated with an @entity101 of clottable fibrinogen not associated with a general increase in protein disappearance rate. Thus an @entity1003 is evident in the polycythemic animals. Whether this @entity1003 is the cause of the @entity3166 or is secondary to the @entity3166 seen in this animal model cannot be determined from this experiment.
