The effect of consuming meat enriched in walnut paste on XXXX and thrombogenesis varies in volunteers with different apolipoprotein A4 genotype.

@entity15783 @entity2404 @entity1423 @entity3447 @entity33449 @entity7647 @entity65
BACKGROUND AND AIM: Low-fat meat (LM) has been considered adequate under a @entity65 point of view. Meat enriched in walnut paste (WM) consumption produces beneficial antithrombogenic effects but with striking inter-individual variability that may be related to gene polymorphism. Variants in the @entity15783 gene ( @entity15783 ) polymorphism are known to affect the cardiovascular risk. This study aimed to compare the effects of consumption of WM and LM on @entity1423 , production of @entity2404 (TXA2) and prostacyclin I2 (PGI2), and the TXA2/PGI2 ratio in 22 volunteers with different @entity15783 polymorphism. SUBJECTS AND METHODS: Six volunteers carried the @entity7647 allele ( @entity15783 -2) while 16 were homozygous for the His allele ( @entity15783 -1). Platelet aggregation, @entity3447 (measured as TXB2), PGI2 (measured as @entity33449 ), and the thrombogenic ratio (TXB2/ @entity33449 ) were determined at baseline and at weeks 3 and 5 for the WM and LM dietary periods. RESULTS: Platelet aggregation decreased significantly (P<0.05) more in @entity15783 -1 than in @entity15783 -2 volunteers at 3-wk WM period, while TXB2 levels dropped more in @entity15783 -2 than in @entity15783 -1 volunteers at 5-wk WM period. TXB2 levels and the TXB2/ @entity33449 ratio decreased significantly more (P<0.05) after 5 wk treatment in @entity15783 -2 than in @entity15783 -1 carriers on the WM diet than on the LM counterpart. However, @entity33449 levels increased more (P<0.05) in @entity15783 -1 than in @entity15783 -2 volunteers after the 5-wk WM period than after the 5-wk LM diet. CONCLUSIONS: Present results suggest that consumption of WM with respect to LM decrease the thrombogenic risk more in Gln carriers than in His/His.
