Is XXXX in an ultrasonographically normal fetus an indication for genetic evaluation?

@entity1 @entity851 @entity11578 @entity2978 @entity2008 @entity2241
OBJECTIVE: Our purpose was to determine the frequency of fetal @entity2008 in pregnancies complicated by @entity2978 . STUDY DESIGN: Between Jan. 1, 1992, and July 31, 1993, an amniotic fluid index was measured prospectively in 2730 third-trimester pregnant @entity1 . Polyhydramnios was defined as an amniotic fluid index > or = 24 cm. A computer search identified all @entity1 born with structural or @entity2008 . RESULTS: Polyhydramnios was detected in 49 of 2730 @entity1 (1.7%). The incidence of @entity2008 was two in 49 (4.1%) compared with three in 2681 (0.12%) among @entity1 with normal fluid (p < 0.05). Six of the 49 newborns had @entity11578 (12.2%), whereas 48 of 2681 (1.8%) @entity11578 occurred in the control group (p < 0.05). Among study @entity1 both fetuses with @entity2008 were @entity851 ; four of the six @entity11578 were associated with an amniotic fluid index > 30 cm. CONCLUSIONS: (1) Polyhydramnios is associated with an increased incidence of @entity2241 . (2) @entity851 fetuses with @entity2978 warrant genetic evaluation. (3) A genetic study is not absolutely indicated for @entity1 with @entity2978 and a sonographically normal fetus.
