Characterization by chromosome painting of balanced and unbalanced X chromosome translocations in XXXX .

@entity1 @entity154 @entity27487 @entity417 @entity2590 @entity2383
@entity2383 chromosome, especially translocations, are rare events in @entity2590 ( @entity2590 ). In a series of 2270 @entity2590 @entity1 analyzed between 1983 and 1994 (Center for @entity1 Genetics, Leuven), 9 cases were found with translocations involving the X chromosome. These aberrations were not restricted to specific FAB subtypes and were the sole anomalies in 3 cases. In the remaining 6 @entity1 , they were associated with other abnormalities, including 5q-, observed in three cases. Fluorescence in situ hybridization (FISH) was retrospectively performed on 8 @entity1 and was shown to be a useful complement for the characterization of the translocations involving the X chromosome. In 3 cases, we could identify translocation partners and breakpoint regions only by using chromosome painting. No recurrent chromosome partners were observed. The breakpoints could be localized along the whole X chromosome. There was, however, a cluster in the Xq13 region involved in 4 of the 9 @entity1 . The previously reported association of @entity154 with @entity417 with @entity27487 (RARS) was found in only one case. Despite the lack of characteristic translocations involving the X chromosome, the occurrence of such changes as the sole karyotypic anomaly suggests that they could play a role in the pathogenesis of some @entity2590 .
