Differential expression of XXXX in pancreas adenocarcinoma: high @entity5 expression is associated with earlier recurrence and shortened survival after resection.

@entity1 @entity11833 @entity788 @entity5 @entity1349
BACKGROUND: Increased @entity5 expression of @entity11833 ( @entity11833 ) is associated with decreased survival in @entity1 with @entity5 . Its effect in @entity788 ( @entity788 ) is not defined. METHODS: Ninety-five @entity1 were selected from a prospective database of all @entity1 (n  =  220) who underwent pancreaticoduodenectomy for @entity788 between January 2000 and October 2008. @entity5 was isolated to perform immunohistochemistry for @entity11833 expression and was graded by a single pathologist. Main outcomes were @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). RESULTS: Median age was 63  years; 50 @entity1 (53%) were male and 73 (77%) received adjuvant chemotherapy. Median follow-up was 25  months. Median @entity1349 and @entity1349 was 9 and 16  months. Median @entity5 size was 3  cm; 26% had a positive resection margin, 34% had poorly differentiated @entity5 , 61% had positive lymph nodes, 88% had perineural invasion, and 45% had lymphovascular invasion. @entity5 exhibited differential @entity11833 expression in terms of intensity staining [none-weak: 61%; moderate-strong: 39%], percentage staining [0: 39%; 1-10: 29%; 11-50: 20%; 51-100: 12%], and overall expression [low: 84%; high: 16%]. High @entity11833 expression was associated with reduced @entity1349 (6 vs. 10  months; P  =  0.03) and decreased @entity1349 (9 vs. 18  months; P  =  0.019). After accounting for @entity5 factors, high @entity11833 expression persisted as a negative prognostic factor on multivariate Cox regression for both @entity1349 and @entity1349 [hazards ratio (HR), 2.1; 95% confidence interval (CI), 1.1-3.9; P  =  0.02; HR, 3; 95% CI, 1.6-6; P  =  0.001, respectively]. A subset analysis of only those 73 @entity1 who received adjuvant therapy revealed the same negative effect of high @entity11833 expression on @entity1349 (4 vs. 15  months; P  =  0.001) and @entity1349 (9 vs. 20  months; P  <  0.001). CONCLUSIONS: @entity788 exhibits differential expression of @entity11833 . High @entity11833 expression is associated with both reduced @entity1349 and @entity1349 after resection. @entity11833 expression levels may help to predict @entity1 outcome with adjuvant chemotherapy.
