Specificity of somatostatin receptor scintigraphy: a prospective study and effects of false-positive localizations on management in XXXX with gastrinomas.

@entity6071 @entity1 @entity4559 @entity66 @entity5 @entity8579 @entity358 @entity45 @entity1558 @entity1374
@entity6071 ( @entity6071 ) is being increasingly used both for localization and, in some cases, diagnosis of @entity66 . There are no prospective studies of its specificity or occurrence of false-positive results and their effects on management. This study was designed to address both of these issues. METHODS: Over a 40-mo period, 146 consecutive @entity1 with @entity8579 ( @entity8579 ) undergoing 480 @entity6071 examinations were studied prospectively. @entity1 were admitted at least yearly and underwent @entity6071 as well as conventional imaging studies (ultrasonography, CT, MRI) and angiography, if necessary. All admissions were assigned to one of five different clinical categories in which imaging studies had different purposes. @entity6071 localizations were classified as true-positive or false-positive based on preset criteria. A false-positive result was determined to change clinical management based on five preset criteria. RESULTS: Of all @entity6071 examinations, 12% resulted in a false-positive localization for a @entity5 or its metastases, resulting in a sensitivity of 71%, specificity of 86% and positive and negative predictive values of 85% and 52%, respectively. Extra-abdominal false-positive localizations (2/3) were more common than intra-abdominal (1/3). @entity1374 , @entity1558 and @entity358 were the most frequent causes of extra-abdominal false-positive localizations. @entity4559 , localization to previous operative sites, renal @entity45 and various procedural aspects were the most frequent causes of intra-abdominal false-positive localizations. Of all @entity6071 studies, 2.7% resulted in a false-positive result that altered management. CONCLUSION: False-positive @entity6071 localization occurs in 1 of 10 @entity1 with @entity8579 . By having a thorough understanding of diseases or circumstances that result in false-positive localization and comparing the @entity6071 result with the clinical context, the percentage of @entity1 in whom false-positive localization results in altered management can be reduced to below 3% and the correct diagnosis made in almost every case.
