Progression of Retinal Pigment Epithelial Atrophy in Antiangiogenic Therapy of Neovascular Age-Related XXXX .

@entity1 @entity10691 @entity1713 @entity194 @entity989 @entity1020
PURPOSE: To monitor @entity989 ( @entity989 ) @entity194 progression during antiangiogenic therapy of neovascular @entity1020 ( @entity1020 ) over 2 years using polarization-sensitive optical coherence tomography (OCT). DESIGN: Prospective interventional case series. METHODS: setting: Clinical practice. STUDY POPULATION: Thirty @entity1 (31 eyes) with treatment-na  ve neovascular @entity1020 . OBSERVATION PROCEDURES: Standard intravitreal therapy (0.5  mg ranibizumab) was administered monthly during the first year and pro re nata (PRN; as-needed) during the second year. Spectral-domain (SD) OCT and polarization-sensitive OCT (selectively imaging the @entity989 ) examinations were performed at baseline and at 1, 3, 6, 12, and 24  months using a standardized protocol. @entity989 -related changes were evaluated using a semi-automated polarization-sensitive OCT segmentation algorithm and correlated with SD OCT and fundus autofluorescence (FAF) findings. MAIN OUTCOME MEASURES: @entity989 response, @entity10691 ( @entity10691 ) progression. RESULTS: Atrophic @entity989 changes included @entity989 thinning, @entity989 porosity, focal @entity1713 , and development of @entity10691 . Early @entity989 loss (ie, @entity989 porosity, focal @entity194 ) increased progressively during initial monthly treatment and remained stable during subsequent PRN-based therapy. @entity10691 developed in 61% of eyes at month 24. Mean @entity10691 area increased from 0.77  mm(2) at 12  months to 1.10  mm(2) (standard deviation  = 1.09  mm(2)) at 24  months. Reactive accumulation of @entity989 -related material at the lesion borders increased until month 3 and subsequently decreased. CONCLUSIONS: Progressive @entity1713 and @entity10691 developed in the majority of eyes. @entity989 migration signifies certain @entity989 plasticity. Polarization-sensitive OCT specifically images @entity989 -related changes in neovascular @entity1020 , contrary to conventional imaging methods. Polarization-sensitive OCT allows for precisely monitoring the sequence of @entity989 -related morphologic changes.
