Benign prognosis of never-symptomatic XXXX .

@entity1 @entity2002 @entity64 @entity26 @entity432 @entity385
OBJECTIVE: To determine the prognosis of asymptomatic @entity432 . BACKGROUND: As opposed to symptomatic @entity432 , little information is available on the prognosis of asymptomatic @entity432 . METHOD: Thirty never-symptomatic and 81 symptomatic @entity1 with @entity432 underwent baseline assessment of 15 risk factors together with PET measurements of @entity26 extraction fraction (OEF). Every 6-month telephone contact recorded interval medical treatment and subsequent @entity64 occurrence during an average follow-up of 32 months. @entity1 , treating physicians, and an end point adjudicator were blinded to PET results. RESULTS: @entity385 occurred in 1 of 30 of never-symptomatic @entity1 (3.3%) and 15 of 81 of symptomatic @entity1 (18.5%; p = 0.03). No @entity64 in the carotid territory distal to the occluded vessel occurred in the never-symptomatic @entity1 . Multivariate analysis of baseline risk factors for all 111 @entity1 revealed that age, plasma @entity2002 level, and PET findings of high OEF distal to the occluded carotid artery were the only independent predictors of subsequent @entity64 (p < 0.05). Previous ipsilateral hemispheric or retinal symptoms was not a significant predictive variable. The lower risk of @entity64 in never-symptomatic @entity1 was associated with a lower incidence of high OEF (4 of 30) as opposed to symptomatic @entity1 (39 of 81; p = 0.002), but there was no significant difference in age or @entity2002 level. CONCLUSIONS: Never-symptomatic @entity432 carries a very low risk of subsequent @entity385 . This benign prognosis is associated with a low incidence of cerebral hemodynamic compromise in these @entity1 . These data support further the importance of hemodynamic factors in the pathogenesis of @entity385 in @entity1 with @entity432 .
