XXXX following the administration of @entity1343 for lumbar plexus block: A report of two cases.

@entity1 @entity410 @entity1425 @entity1372 @entity149 @entity1341 @entity1343 @entity1370 @entity65 @entity2900
BACKGROUND AND OBJECTIVES: Central nervous system and @entity1370 following the administration of local anesthetics is a recognized complication of regional anesthesia. @entity1343 , the pure S(-) enantiomer of @entity1341 , was developed to improve the cardiac safety profile of @entity1341 . We describe 2 cases of grand @entity410 following accidental intravascular injection of @entity1343 . CASE REPORT: Two @entity1 presenting for elective orthopedic surgery of the lower limb underwent blockade of the lumbar plexus via the posterior approach. Immediately after the administration of @entity1343 0.5% with @entity1425 2.5 microgram/mL, the @entity1 developed grand @entity410 , despite negative aspiration for blood and no clinical signs of intravenous @entity1425 administration. The @entity410 were successfully treated with @entity1372 thiopental in addition to @entity2900 in 1 @entity1 . Neither @entity1 developed signs of @entity65 . Both @entity1 were treated preoperatively with beta-adrenergic antagonist medications, which may have masked the cardiovascular signs of the unintentional intravascular administration of @entity1343 with @entity1425 . CONCLUSIONS: Although @entity1343 may have a safer @entity1370 profile than racemic @entity1341 , if adequate amounts of @entity1343 reach the circulation, it will result in @entity410 . Plasma concentrations sufficient to result in @entity149 did not produce manifestations of @entity1370 in these 2 @entity1 .
