Comparison of grey matter @entity194 between @entity1 with @entity1652 and XXXX : a voxel-based morphometry study.

@entity1 @entity1652 @entity3780 @entity1315 @entity194 @entity62 @entity15 @entity528
PURPOSE: Previous studies have established regional grey matter (GM) loss in @entity15 ( @entity15 ). However, whether there is any regional @entity194 in @entity1652 ( @entity1652 ) and the difference between @entity1652 and @entity15 is unclear. The present study addresses this issue by voxel-based morphometry (VBM). METHODS: Conventional magnetic resonance imaging (MRI) and T1-weighted three-dimensional MRI were obtained from 26 @entity1652 @entity1 , 26 @entity3780 ( @entity3780 ) @entity1 , and 26 normal controls. An analysis of covariance model assessed with cluster size inference was used to compare GM volume among three groups. The correlations of GM volume changes with disease duration, expanded disability status scale (EDSS) and brain T2 lesion volume (LV) were analyzed. RESULTS: @entity194 was found in @entity1652 @entity1 in several regions of frontal, @entity1315 (uncorrected, p < 0.001). While extensive @entity194 was found in @entity3780 @entity1 , including most cortical regions and the deep grey matter (corrected for multiple comparisons, p < 0.01). Compared with @entity1652 , those with @entity3780 had significant @entity62 in bilateral thalami, caudate, left parahippocampal gyrus, right hippocampus and insula (corrected, p < 0.01). In @entity3780 group, regional @entity62 in right caudate and bilateral thalami were strongly correlated with brain T2LV. CONCLUSIONS: Our study found the difference of @entity194 between @entity1652 and @entity3780 @entity1 mainly in deep grey matter. The correlational results suggested @entity528 from lesions on T2WI may be a key pathogenesis of @entity194 in deep grey matter in @entity3780 .
