Acute stress response modified by modest inhibition of XXXX axis: a potential machinery of the anti-aging effect of calorie restriction.

@entity568 @entity1505 @entity11249 @entity2135 @entity492 @entity164 @entity35 @entity4026
Calorie restriction (CR) may exert antiaging effects by inhibiting the @entity11249 ( @entity11249 )/ @entity2135 axis. The present study investigated the effect of modest inhibition of @entity11249 signaling on stress response and compared it with the effect of CR. Heterozygous (tg/-) @entity35 of a transgenic strain of male @entity35 , whose @entity11249 signaling was inhibited by overexpression of the anti-sense @entity11249 gene, and @entity164 ( @entity164 ) @entity35 were used. @entity35 were fed ad libitum (AL) or 30% CR diets from 6 weeks of age. At 6 months of age, @entity35 were killed between 0 and 8h after lipopolysaccharide (LPS) injection to evaluate the acute phase stress response. tg/- @entity35 had less tissue injury, indicated by blood @entity492 aminotransferase (AST) concentrations, than @entity164 @entity35 . Successive waves of incremental plasma @entity1505 , @entity568 , and interferon (IFN)-y levels were also attenuated in tg/- @entity35 . Activation of @entity4026 , a redox-sensitive transcription factor, was slightly diminished in tg/- @entity35 , whereas the AP-1 activity was increased. Similar trends were also observed in the CR groups as compared to the AL groups. The present results suggest an involvement of the @entity11249 / @entity2135 axis in the effect of CR for stress response, even if CR does not act solely through the @entity11249 axis.
