XXXX , adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study.

@entity1 @entity102 @entity209 @entity413 @entity165
BACKGROUND AND AIMS: To better understand the @entity209 ( @entity209 ) spectrum through principal components analysis and further evaluate the role of the Mediterranean diet on @entity209 presence. METHODS: During 2001-2002, 1514 @entity1 and 1528 @entity1 (>18y) without any clinical evidence of CVD or any other @entity102 , at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 @entity1 (15% of the @entity1 were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. @entity209 was defined by the National @entity165 Education Program Adult Treatment panel III (revised NCEP ATP III) definition. Adherence to the Mediterranean diet was assessed using the MedDietScore (range 0-55). RESULTS: Five principal components were derived, explaining 73.8% of the total variation, characterized by the: a) body weight and lipid profile, b) blood pressure, c) lipid profile, d) @entity413 profile, e) inflammatory factors. All components were associated with higher likelihood of CVD incidence. After adjusting for various potential confounding factors, adherence to the Mediterranean dietary pattern for each 10% increase in the MedDietScore, was associated with 15% lower odds of CVD incidence (95%CI: 0.71-1.06). For the @entity1 with low adherence to the Mediterranean diet  all five components were significantly associated with increased likelihood of CVD incidence. However, for the ones following closely the Mediterranean pattern positive, yet not significant associations were observed. CONCLUSION: Results of the present work propose a wider @entity209 definition, while highlighting the beneficial role of the Mediterranean dietary pattern.
