Measures of Obesity and Risk of XXXX and @entity31 .

@entity1 @entity32 @entity28 @entity31 @entity29 @entity30
BACKGROUND:: Obesity is associated with intestinal-specific @entity32 . Nonetheless, a specific role of @entity28 in the etiology of @entity29 is unclear. METHODS:: We conducted a prospective cohort study of U.S. @entity1 enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs). RESULTS:: Among 111,498 @entity1 (median age, 35 yr), we documented 153 cases of @entity30 ( @entity30 ) and 229 cases of @entity31 ( @entity31 ) more than 18 years of follow-up, encompassing 2,028,769 @entity1 -years. Compared with @entity1 with normal BMI, the multivariate-adjusted hazard ratios of @entity30 were 2.33 (95% CI, 1.15-4.69) for @entity28 @entity1 at age 18 and 1.58 (95% CI, 1.01-2.47) for @entity28 @entity1 at baseline. Increasing weight gain between age 18 and baseline was associated with increased risk of @entity30 (Ptrend = 0.04). Adolescent body habitus was also associated with risk of @entity30 with a multivariate-adjusted hazard ratio of @entity30 of 1.63 (95% CI, 1.07-2.50) for @entity1 with @entity28 compared with @entity1 with a thin/slender body shape. We did not observe a significant association between any of these anthropometric measures and risk of @entity31 . CONCLUSIONS:: In a large prospective cohort of U.S. @entity1 , measures of adiposity were associated with an increased risk of @entity30 but not @entity31 . Additional studies are needed to elucidate the biological mechanisms by which excess adiposity may increase the risk of @entity30 .
