Age of onset of type 1 @entity6 in XXXX and carotid intima medial thickness.

@entity1 @entity101 @entity6 @entity2690 @entity731 @entity121 @entity65 @entity165
CONTEXT: @entity65 due to @entity731 is a major cause of morbidity and mortality in adult @entity6 @entity1 . In @entity1 , signs of subclinical @entity731 such as increased @entity121 ( @entity121 ) of the common carotid arteries have been detected in several studies. However, concerns may arise about the different analyzing methods used because measurements in @entity1 and controls differ significantly. @entity1 AND METHODS: We studied 208 @entity1 [150 @entity1 with @entity6 , mean age (+/-sd) 13.9 +/- 2.8 yr, 66 males, mean glycosylated hemoglobin (+/-sd) 7.8 +/- 1.4%, and 58 healthy controls, mean age (+/-sd) 14.1 +/- 3.1 yr, 32 males] and used normal @entity121 values published recently for comparison of the results. RESULTS: Of 150 @entity1 , 37 had an increased @entity121 [mean @entity121 (+/-sd) 1.6 +/- 0.6], whereas healthy controls had nearly normal @entity121 values [mean @entity121 (+/-sd) 0.3 +/- 0.1; P < 0.001]. Age at onset of @entity6 , mean daily @entity2690 dosage, systolic blood pressure, and total @entity165 level were significantly related to @entity121 in a multilinear regression model. A total of 25 @entity6 @entity1 were @entity101 and had a significantly increased @entity121 (mean @entity121 0.475 +/- 0.03 mm) compared to the remaining @entity1 (mean @entity121 0.459 +/- 0.02 mm; P < 0.05). CONCLUSIONS: The @entity121 measurement detected subclinical @entity731 in a large cohort of @entity6 @entity1 . Systolic blood pressure, total @entity165 level, @entity2690 dosage, and age at onset of the disease were significantly related to the @entity121 . Longitudinal measurements may help to identify @entity1 at special risk for @entity731 changes and @entity65 .
