An update on XXXX treated with neutrons at Fermilab.

@entity5 @entity1
One hundred and thirteen cases of recurrent and/or unresectable @entity5 , treated with fast neutron therapy at Fermilab between September 1976 and December 1984, are analyzed for local control, sites of failure, and treatment-related morbidity. Sixty-three @entity1 had major and 55 had @entity5 . Local control was achieved in 67% of @entity1 with major and 58% of @entity1 with @entity5 . In the subgroup of @entity1 with oropharyngeal and oral cavity lesions, 19/24 (80%) had local control. However, only four of 15 @entity1 with @entity5 had successful control of their disease. Seventy-four percent of @entity1 with lesions measuring 5 cm or less and 30% of @entity1 with larger lesions had their local disease controlled. Histology did not influence the local control rate. Both observed and adjusted median survival for @entity1 with major @entity5 was 36 months. Disease-free survival was 31 months. Observed and adjusted median survivals for @entity1 with @entity5 are 48 and 57 months respectively. Twenty of 86 @entity1 (23%) had major morbidity; this was directly related to the total dose delivered. In the dose range 20-24 Gy the complication rate was 16%. Most of these complications were successfully managed with minimal functional disability. We have concluded that fast neutron irradiation is an appropriate treatment for @entity5 .
