@entity25104 Peels/ XXXX 20% Cream Combination and Low Potency Triple Combination Lead to Similar Reduction in Melasma Severity in Ethnic Skin: Results of a Randomized Controlled Study.

@entity1 @entity25104 @entity21289 @entity8156 @entity24402 @entity1709 @entity1968
BACKGROUND: Numerous therapeutic options have been tried in the management of @entity1709 . AIMS AND OBJECTIVES: This prospective randomized study was planned to assess the efficacy of low potency triple combination (TC) cream (TC- @entity8156 2%/ @entity1968 0.05%/ @entity21289 0.01%) versus @entity25104 (GA) peels/ @entity24402 (AA) 20% cream (GA/AA) combination in @entity1709 . MATERIALS AND METHODS: Forty @entity1 with @entity1709 were recruited into this study and randomized into two groups. Group A consisting 20 @entity1 received TC cream once a day for night time application for 3 months. Group B comprising of 20 @entity1 received GA/AA 20% cream combination for 3 months. The disease severity was monitored with digital photography, @entity1709 area and severity index (MASI) score, which was calculated at baseline, 6 weeks and 12 weeks, and visual analog scale (VAS) score, which was calculated at baseline and 12 weeks. RESULTS: Of 40 @entity1 , 38 were completed the study. A significant reduction in MASI and VAS was recorded after 6 weeks and 12 weeks of treatment in both groups A and B (P = 0.001). However, there was no significant difference in the mean MASI scores between the two groups at baseline, 6 weeks and 12 weeks. Similarly, there was no difference in the mean VAS scores between the two groups at baseline and 12 weeks. Four @entity1 in group A and 3 in group B experienced adverse effects such as irritation, dryness, and photosensitivity. CONCLUSION: Both low potency TC cream and GA/AA 20% cream combination are effective in treating @entity1709 among Indian @entity1 .
