Hh- XXXX signaling pathway activity in oral and @entity957 .

@entity1 @entity286 @entity986 @entity167 @entity5 @entity957 @entity2751 @entity8889 @entity4851 @entity2750
BACKGROUND: The aim of this study was to examine the role of Hh- @entity8889 signaling in oral and @entity957 (SCC). The role of this signaling pathway in SCC formation has not yet been elucidated. METHODS: Sixty-four tissue and blood samples were collected from 60 @entity1 with SCC, all @entity286 and @entity167 users. An additional six buccal mucosa tissue samples were collected from nonsmokers and nondrinkers as control tissue. RESULTS: Hedgehog- @entity8889 pathway components were associated with clinical and pathologic features. Broders' grade and N stage were associated with higher @entity2750 and lower @entity8889 expression. @entity5 stage was negatively associated with @entity2751 expression, and @entity5 size was positively associated with @entity986 expression. @entity2750 and @entity4851 were frequently detected in the surrounding stroma. @entity2750 was found to be correlated with @entity986 expression, as well as with survivin expression. CONCLUSIONS: The signaling pathway is activated in SCC and inducible in vitro by @entity4851 protein.
