Topical XXXX for relaxation of dysfunctional bladders.

@entity1 @entity322 @entity409 @entity11440 @entity427
Eleven @entity1 with persistent urge @entity322 and frequent side effects on oral anticholinergic agents were treated with @entity11440 administered intravesically. Five mg. tablets were dissolved in saline, and the solution was instilled twice daily and retained for 30 minutes. One @entity1 was unable to retain the medication because of severe @entity427 and was eliminated from the study. The remaining 10 @entity1 all reported subjective improvement following treatment and all became totally continent. No side effects were observed. In these 10 @entity1 mean bladder capacity increased from 224 to 360 ml. (p less than 0.01) and mean maximum filling pressure decreased from 33 to 24 cm. water (p equals 0.17). Two additional @entity1 with continent ileocecal urinary diversions were treated with topical @entity11440 instilled directly into the intestinal reservoir. Both @entity1 reported improved comfort with filling and 1 demonstrated a decrease in uninhibited contractions. These encouraging results suggest that treatment with topical @entity11440 is an effective alternative in @entity1 with @entity409 who either are unresponsive to or have intolerable side effects on oral medications.
