Nonfasting @entity165 and XXXX and association with risk of @entity583 and total mortality: the Copenhagen City Heart Study with 31 years of follow-up.

@entity1 @entity583 @entity1674 @entity165
OBJECTIVES: We compared the ability of very high levels of nonfasting @entity165 and @entity1674 to predict risk of @entity583 and total mortality. DESIGN: Prospective study from 1976 to 1978 until 2007. SETTING: Danish general population. @entity1 : Randomly selected population of 7581 @entity1 and 6391 @entity1 , of whom 768 and 1151 developed @entity583 and 4398 and 4416 died, respectively. Participation rate was 72%, and follow-up was 100% complete. Less than 2% of @entity1 were taking lipid-lowering therapy. RESULTS: Compared to @entity1 with @entity165 <5 mmol L(-1) , multivariate-adjusted hazard ratios for @entity583 ranged from 1.3 [95% confidence interval (CI): 0.9-1.8] for a @entity165 level of 5.0-5.99 mmol L(-1) to 2.5 (95%CI: 1.6-4.0) for @entity165 >=  9 mmol L(-1) (trend: P < 0.0001). Compared with @entity1 with nonfasting @entity1674 <1 mmol L(-1) , hazard ratios for @entity583 ranged from 1.5 (95%CI: 1.2-1.8) for @entity1674 of 1.0-1.99 mmol L(-1) to 4.2 (95%CI: 2.5-7.2) for @entity1674 >=  5 mmol L(-1) (p<0.0001). In @entity1 , corresponding hazard ratios ranged from 1.2 (95%CI: 1.0-1.5) to 5.3 (95%CI: 3.6-8.0) for @entity165 (P < 0.0001) and from 1.3 (95%CI: 1.0-1.6) to 2.1 (95%CI: 1.5-2.8) for @entity1674 (P < 0.0001). Increasing @entity165 levels were not consistently associated with total mortality in @entity1 (trend: P = 0.39) or @entity1 (P = 0.02). By contrast, compared with @entity1 with @entity1674 <1 mmol L(-1) , multivariate-adjusted hazard ratios for total mortality ranged from 1.1 (95%CI: 1.0-1.2) for @entity1674 of 1.0-1.99 mmol L(-1) to 2.0 (95%CI: 1.5-2.9) for @entity1674 >= 5 mmol L(-1) (trend: P < 0.0001); corresponding hazard ratios in @entity1 ranged from 1.1 (95%CI: 1.0-1.2) to 1.5 (95%CI: 1.2-1.7) (P < 0.0001). CONCLUSIONS: Stepwise increasing levels of nonfasting @entity165 and nonfasting @entity1674 were similarly associated with stepwise increasing risk of @entity583 , with nonfasting @entity1674 being the best predictor in @entity1 and nonfasting @entity165 the best predictor in @entity1 . Even more surprisingly, only increasing levels of nonfasting @entity1674 were associated with total mortality, whereas increasing @entity165 levels were not.
