Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 @entity6 XXXX .

@entity2175 @entity1 @entity650 @entity8 @entity101 @entity28 @entity2299 @entity310 @entity6 @entity73116 @entity73115 @entity2533 @entity379 @entity73117 @entity28707 @entity688 @entity28709
Aims. The polymorphisms of pro- and anti-inflammatory cytokines may be involved in @entity2175 ( @entity2175 ) pathogenesis and its complications. Methods. We investigated in 102 @entity2175 @entity1 the association of the cytokine polymorphisms in the @entity310 , @entity688 , @entity650 , @entity2533 , and @entity379 genes with the @entity2175 microvascular complications and comorbidities ( @entity101 , @entity2299 , and @entity28 ). Cytokine genotypes were determined by PCR using Cytokine Genotyping Tray kit. Results. @entity6 was associated with GG genotype and G allele in @entity2533 @entity73115 polymorphism (p = 0.004 and p = 0.018) and the @entity8 was associated the lower frequency of GG genotype in @entity688 @entity28707 polymorphism (p = 0.049). @entity101 was associated with the CC genotype and C allele for @entity688 @entity28709 polymorphism (p = 0.013 and p = 0.009) and higher frequencies of T (p = 0.047) and C (p = 0.033) alleles of the @entity2533 @entity73116 and @entity688 @entity73117 polymorphisms, respectively. The @entity2533 @entity73116 polymorphism was associated with the BMI groups (p = 0.026): the CC genotype was more frequent in the group with BMI < 25   Kg/m(2), while the TC genotype was more frequent in the group with BMI = 30   Kg/m(2). Conclusions. Our findings suggest that @entity2533 and @entity688 polymorphisms are involved in complications and comorbidities in @entity2175 @entity1 .
