Antibiotic desensitization in adults with XXXX .

@entity1 @entity3405 @entity566 @entity56 @entity1577 @entity288
OBJECTIVE: @entity56 to antibiotics occur in up to 30% of @entity1 with @entity1577 ( @entity1577 ). Repeated antibiotic exposure and immune hyper-responsiveness increase the risk of @entity56 and may limit antibiotic choice. Desensitization may allow the successful administration of an antibiotic despite previous @entity566 . We aimed to determine the success of antibiotic desensitization in @entity1 with @entity1577 in an adult @entity1577 unit over a 7-year period. METHODOLOGY: A retrospective medical record review was performed on the 19 @entity1 who had undergone antibiotic desensitization procedures. Data collected included drug @entity566 and intolerance profiles, nature of @entity566 , and the outcome of desensitization procedures. Desensitization procedures were performed in a ward setting according to published methods. RESULTS: Nineteen @entity1 (13 females) reported 62 @entity56 with a mean of 3.3 per @entity1 . Of the 71 desensitization procedures undergone by this group, 54 (76%) were successful. Fifteen of the 19 @entity1 were @entity56 to two or more @entity3405 antibiotics. Over half of the @entity1 were desensitized to more than one antibiotic. Nine different antibiotics were used in 31 different @entity1 /drug combinations. A successful outcome was achieved in 18/31 (58%) combinations, with three requiring treatment for mild @entity56 . @entity56 caused drug cessation in a total of 19 @entity1 /drug combinations (three after initial successful desensitization and full courses of antibiotics). Over 50% of these reactions occurred on day 1. Desensitization failures were more common in @entity1 with well-documented @entity56 to a specific drug. CONCLUSION: This study demonstrates that multiple antibiotic @entity566 are common in adults with @entity1577 . Cross-reactivity between @entity3405 antibiotics may limit antibiotic choice for the treatment of pulmonary exacerbations. Antibiotic desensitization allows safe and successful treatment in the ward setting of many @entity1 with previous @entity566 to an antibiotic. In many @entity1 symptoms of @entity566 still occur and result in cessation of the antibiotics. Use of @entity288 and antihistamines may improve the success rate of desensitization procedures.
