Budding is useful to select high-risk XXXX in stage II well-differentiated or moderately differentiated colon adenocarcinoma.

@entity1 @entity5 @entity1711 @entity1710 @entity14 @entity3 @entity34
PURPOSE: Budding at the invasive front of @entity5 has recently been thought to suggest greater malignant potential of the @entity14 . We examined whether budding is associated with poor prognosis after curative resection in Stage II and @entity5 . Furthermore, we examined whether budding is useful to select high-risk @entity1 in @entity5 . METHODS: Surgically resected specimens of 196 @entity5 were studied. All the resections were curative (R0), and the median postoperative follow-up was 75.5 months. Using @entity1710 - @entity1711 -stained sections, we determined the presence or absence of budding according to Morodomi's criteria. Routine pathologic findings were also recorded. RESULTS: Budding was detected significantly more frequently in lesions with lymph node @entity3 (Stage III) than in lesions without it (Stage II; P < 0.0001). @entity1 with budding-positive lesions had worse outcome than those with budding-negative lesions: 43 @entity1 (50.6 percent) with budding-positive lesions and 9 (8.1 percent) with budding-negative lesions developed recurrence (P < 0.0001). @entity1 with budding-positive lesions had a worse prognosis than @entity1 without it (P < 0.0001). Moreover, no significant difference in survival curves was observed between @entity1 with budding-positive @entity34 and those with @entity5 (P = 0.930). Multivariate analysis revealed budding as the significant prognostic cofactor of postoperative survival in Stage II and @entity5 (P < 0.0001). CONCLUSION: Budding is useful to select high-risk @entity1 in @entity5 .
