A Systematic Review Investigating the Presence of Inflammatory XXXX in Hip and Knee Joint Replacement Surgery.

@entity32 @entity571 @entity603
Synovial tissue can display an inflammatory response in the presence of @entity571 . There is increasing interest to better understand the role of @entity32 in @entity571 , particularly with regard to those who require joint replacement. A systematic review of @entity32 in @entity571 of literature databases was undertaken from their inception until October 14, 2014. Independent critical appraisal of each study was undertaken using the CASP appraisal tool. From a total of sixty-six identified citations, twenty-three studies were deemed eligible for review. The studies presented moderate to strong methodological quality. Strong correlation was identified between histological and imaging @entity603 severity. Correlation was weaker between clinical symptoms and imaging and/or histological @entity603 severity. There was little consensus, with regard to expressed cytokines and chemokines at the different stages of @entity571 disease progression. Few studies investigated the influence of @entity32 on the outcome of major joint replacement. Research into @entity32 in @entity571 is an emerging field. Longitudinal studies applying proven imaging modalities, histological analysis, and longer follow-up are required in order to further define our understanding of the role of @entity603 in the pathogenesis of @entity571 and its effects on outcomes following major joint replacement.
