Time-dependent change in electrophysiologic milieu after @entity583 in conscious XXXX .

@entity235 @entity583 @entity1188 @entity1165
This study was designed to assess the time-dependent change in propensity to induction of malignant @entity1165 after @entity583 . Instrumented conscious @entity235 were assessed during serial drug-free electrophysiologic studies over 26 +/- 9 days (range 17 to 35 days) after 2 hr occlusion-reperfusion of the left anterior descending coronary artery. Of the 19 animals studied, 11 continued to have sustained @entity1165 inducible (group I) over this time period. In the eight remaining animals, spontaneous loss in the ability to induce sustained @entity1165 occurred (group II). @entity583 size in group I animals (18 +/- 8%) was significantly greater than that in group II @entity235 (12.5 +/- 5%; p less than .05). Even in group I animals, time-dependent changes occurred in the number of extrastimuli required to induce @entity1165 and the frequency with which left ventricular stimulation was necessary. A differential pattern of time-dependent changes in electrophysiologic variables was observed when comparing group I and II animals. The conduction time to the @entity1188 zone was prolonged during follow-up in group I animals, while in group II animals this variable was unchanged. Repolarization time recorded in the border zone remained unchanged in group I animals, but it was significantly shortened in group II animals. In addition, ventricular effective refractory period in the @entity1188 zone shortened over time in group I animals but did not change in group II animals. In conclusion, time-dependent changes occur in electrophysiologic variables that are associated with a progressive decrease in propensity to induction of @entity1165 after @entity583 . A critical determinant of whether propensity to @entity1165 resolves over time is size of @entity583 .
