Similar insulin sensitivity in @entity2175 XXXX with normo- and microalbuminuria.

@entity2175 @entity1 @entity6 @entity1009 @entity633 @entity3190 @entity413
OBJECTIVE: To investigate whether insulin resistance and microalbuminuria are associated in @entity2175 ( @entity2175 ). RESEARCH DESIGN AND METHODS: Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric @entity2175 @entity1 matched for sex, age, body composition, glycemic control, @entity6 duration, and therapy. RESULTS: Isotopically determined @entity413 disposal was similar in normo- and microalbuminuric @entity1 in the basal state (mean +/- SD; 3.30 +/- 1.01 vs. 3.46 +/- 0.82 mg.kg lean body mass [LBM]-1. @entity1009 ; NS) and during @entity3190 (7.16 +/- 2.65 vs. 6.63 +/- 2.88 mg.kg LBM-1. @entity1009 ;NS). No difference was observed in nonoxidative @entity413 disposal or lipid oxidation. Endogenous @entity413 production was equally suppressed by insulin (-0.08 +/- 0.99 vs. 0.30 +/- 1.12 mg.kg-1 LBM. @entity1009 ; NS). @entity413 oxidation tended to be lower in the normoalbuminuric @entity1 in the basal state (1.16 +/- 0.37 vs. 1.41 +/- 0.36 mg.kg LBM-1. @entity1009 ) and during @entity3190 (2.35 +/- 0.72 vs. 2.90 +/- 0.77 mg.kg LBM-1. @entity1009 ; both P < 0.15). Urinary albumin excretion rate correlated with the insulin-stimulated @entity413 oxidation rate (r = 0.59, P = 0.0064), and a similar trend was seen in the basal state (r = 0.42, P = 0.063). Protein oxidation was higher in normoalbuminuric @entity1 (1.6 +/- 0.5 vs. 1.0 +/- 0.4 mg.kg LBM-1. @entity1009 ; P = 0.017) and correlated inversely with @entity633 (r = -0.70, P = 0.0007). Serum growth hormone increased during insulin infusion; however, the increase was significantly greater in microalbuminuric @entity1 . Plasma lipoproteins, maximal aerobic capacity, and 24-h ambulatory blood pressure were similar in the two groups. CONCLUSIONS: Basal and insulin-stimulated @entity413 uptakes are comparable in carefully matched normo- and microalbuminuric @entity2175 @entity1 , and @entity413 oxidation may be positively related to @entity633 . The inverse relation between protein oxidation and @entity633 may be due to higher growth hormone levels during daily life perturbations in @entity413 in microalbuminuric @entity1 .
