Glomerular response to @entity1855 by isolated spontaneously @entity101 XXXX kidney.

@entity35 @entity1855 @entity1063 @entity101
We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity101 @entity35 (SHR) kidneys as compared with kidneys from @entity35 -Kyoto control (WKY) @entity35 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity1063 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity1063 elicited similar changes. Addition of @entity1855 , 5-10 microM, in the presence of @entity1063 returned RVR to 100-110% of control. With @entity1855 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity1063 and @entity1855 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity1063 and @entity1855 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity1855 but not to @entity1063 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.
