Predictive factors of invasion in eyes with XXXX enucleated after eye salvage treatments.

@entity1 @entity231 @entity548 @entity5 @entity1713 @entity1781 @entity5151 @entity3 @entity2297 @entity995
BACKGROUND: The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with @entity995 enucleated following chemoreduction is not well known. PROCEDURE: Twenty-five eyes (23 @entity1 ) with @entity995 enucleated after failing eye-salvage therapy were evaluated. Reasons for enucleation ( @entity5 progression, subretinal or vitreous seeds) and co-morbid conditions ( @entity2297 , @entity231 , @entity548 and @entity1713 ) were documented. All specimens were reviewed for evidence of ciliary body, @entity1781 , and scleral invasion. RESULTS: The median age at diagnosis was 14 months (range, 1-37 months). Twenty eyes were classified as Reese-Ellsworth Group IV-V at diagnosis. Twenty-four eyes had recurrent disease at enucleation; one eye was enucleated for @entity2297 and @entity548 . Co-existing ocular morbidities at enucleation included @entity548 (n = 6), @entity1713 (n = 9), @entity2297 (n = 9) and @entity231 (n = 3). Histologic findings included @entity3 (n = 7), ciliary body invasion (n = 4), @entity5151 (n = 6) and scleral invasion (n = 3). The median time from diagnosis to enucleation was 11 months. Co-existing @entity1713 and @entity548 significantly increased the likelihood of @entity5151 (P = 0.014 and P = 0.011, respectively). Prolonged time to enucleation was significantly associated with the likelihood of choroidal (P = 0.010) and ciliary body (P = 0.021) invasion as well as invasion of multiple sites. CONCLUSION: In eyes with @entity995 enucleated after chemoreduction, co-existing ocular morbidities and time to enucleation are predictive of extra-retinal extension.
