Expression of endothelins and their receptors in cells from XXXX periodontal tissues.

@entity1 @entity8994 @entity2520 @entity2232 @entity75 @entity5 @entity1627 @entity2521 @entity1575 @entity2231
OBJECTIVE: The present study investigated the presence of @entity2232 in gingival crevicular fluid (GCF) from @entity1 with @entity2521 , and the expression of endothelins (ETs) and their receptors mRNA in cultured cells from @entity1 periodontal tissues. BACKGROUND: ET was originally discovered as a potent vasoconstrictive peptide from endothelial cells. It has been reported that ETs are produced by various cells besides endothelial cells. ETs are related to inflammatory and @entity75 , such as @entity8994 and @entity1575 . Therefore, ETs may be involved in @entity2520 . However, the roles of ETs in development and progression of @entity2520 are not clear. METHODS: @entity2232 released from the cultured cells was measured by enzyme-linked immunosorbent assay. mRNA expressions for ETs and their receptors were examined by reverse transcription-polymerase chain reaction and Northern blotting analysis. RESULTS: @entity2232 levels in GCF from @entity1 with @entity2521 were higher than those from healthy subjects. @entity1 gingival keratinocytes (HGK) expressed mRNA for ETs and their receptors, @entity2231 and @entity1627 . @entity2232 mRNA expression and @entity2232 peptide production from HGK were enhanced by interleukin-1beta and @entity5 necrosis factor-alpha. CONCLUSIONS: These results suggest that @entity2232 plays a significant role in @entity2520 .
