Evaluation of the Average Daily Risk Range as a Measure of Glycemic Variability in Youths with Type 1 XXXX .

@entity6 @entity4053 @entity413 @entity1602 @entity4854
OBJECTIVE: The Average Daily Risk Range (ADRR) is a measure of glycemic variability (GV) developed for adults with @entity6 . Although the ADRR is increasingly being reported in pediatric @entity6 research and may also be used in clinical management, it has never been examined for its sensitivity to predicting @entity4053 in youths or compared for its predictive ability with other measures of GV in youths. Thus, we present predictive validity data for the ADRR in youths with type 1 @entity6 . MATERIALS AND METHODS: Glucometer data for 436 youths (mean age, 11.8  3.8 years) were collected from a clinical database. Using these data, we computed the ADRR, SD of blood @entity413 , coefficient of variation of blood @entity413 , Low Blood @entity413 Index, High Blood @entity413 Index, the percentage of @entity413 values >= 70 and  <=180   mg/dL, the percentage of high @entity413 values >180   mg/dL and >400   mg/dL, and the percentage of low @entity413 values <70   mg/dL and <40   mg/dL in Month 1. We then compared these with episodes of hypo- and @entity4854 in Month 2. RESULTS: The ADRR showed good concurrent validity with other measures of GV in youths experiencing @entity1602 events but limited predictive validity in general and specifically with future hypoglycemic events. The percentages of current hyper- and hypoglycemic episodes appeared to be stronger predictors of future hyper- and hypoglycemic episodes, respectively. CONCLUSIONS: In a large pediatric sample, the ADRR was not the strongest predictor of future glycemic excursion. The percentages of current hyper- and hypoglycemic episodes appear to be stronger predictors.
