Early Postnatal @entity2227 Treatment Results in Altered Vascular Responsiveness to @entity750 and @entity1063 in Adult XXXX .

@entity5542 @entity2227 @entity750 @entity35 @entity1063 @entity934
OBJECTIVES: To evaluate possible alterations of vascular responsiveness to vasoactive hormones in the vessel preparations from adult @entity35 treated neonatally with high doses of @entity2227 . METHODS: The responses to @entity1063 and @entity750 in perfused hindlimb vascular bed and isolated renal artery were measured in @entity5542 -treated (2 and 4 mg/g BW) and control groups of adult @entity35 at the age of 10 weeks. Acetylcholine test was used to assess the endothelium-dependent relaxation of the hindlimb vascular preparation. The vessel specimens from this vascular bed were evaluated histologically. RESULTS: Vasoconstrictory responses to @entity1063 and @entity750 were significantly reduced in the hindlimb vascular bed in @entity5542 -treated @entity35 . In the renal artery, a significant decrease of the responses to @entity1063 was found without significant changes in the responses to @entity750 . The observed changes were more pronounced in groups treated with a high dose of @entity5542 . Comparison of relaxing responses to @entity934 in the hindlimb preparation did not show any statistically significant differences in control and @entity5542 treated groups. Histological evaluation of this preparations did not reveal any endothelial damage or morphological changes of vessel wall. CONCLUSIONS: The obtained results showed reduced vascular responsiveness to vasoconstrictory agents in adult @entity35 neonatally treated with @entity5542 suggesting that early postnatal administration of @entity2227 may result in irreversible changes in cardiovascular function.
