In Vitro Toxic Effects of XXXX Nanoparticles on @entity35 Adipose Tissue-Derived Mesenchymal Stem Cells.

@entity137 @entity39 @entity1947 @entity98 @entity3460 @entity2454 @entity35 @entity8175 @entity1948
OBJECTIVE: @entity1947 nanoparticles ( @entity1948 -NPs) are increasingly used in sunscreens, bio- sensors, food additives, pigments, manufacture of rubber products, and electronic materi- als. There are several studies about the effects of NPs on dermal fibroblast or keratino- cytes, but very little attention has been directed towards adipose-derived mesenchymal stem cells (ASCs). A previous study has revealed that @entity1948 -NPs restricted the migration capability of ASCs. However, the potential @entity137 of these NPs on ASCs is not well un- derstood. This study intends to evaluate the effects of @entity1948 -NPs on subcutaneous ASCs. MATERIALS AND METHODS: In this experimental study, In order to assess @entity137 , we ex- posed @entity35 ASCs to @entity1948 -NPs at concentrations of 10, 50, and 100   g/ml for 48 hours. @entity8175 - icity was evaluated by cell morphology changes, cell viability assay, as well as apoptosis and @entity39 detection. RESULTS: @entity1948 -NPs concentration dependently reduced the survival rates of ASCs as re- vealed by the @entity3460 exclusion and @entity2454 ( @entity98 ) tests. @entity1948 -NPs, at concentrations of 10 and 50   g/ml, induced a significant increase in apoptotic indices as shown by the annexin V test. The concentration of 10   g/ml of @entity1948 -NPs was more toxic. CONCLUSION: Lower concentrations of @entity1948 -NPs have toxic and apoptotic effects on subcutaneous ASCs. We recommend that @entity1948 -NPs be used with caution if there is a dermatological problem.
