Co-Expression of XXXX and @entity18436 in @entity957 Is Associated with Poor Survival.

@entity1 @entity146 @entity5 @entity72699 @entity957 @entity5962 @entity13938 @entity18075 @entity18436 @entity3 @entity8945 @entity204
UNASSIGNED: @entity957 ( @entity957 ) is an aggressive disease accounting for more than 260,000 @entity5 cases diagnosed and 128,000 @entity204 worldwide. A large majority of @entity5 @entity204 result from @entity5 that have metastasized beyond the primary @entity5 . The relationship between genetic changes and clinical outcome can reflect the biological events that promote @entity5 's @entity146 , and these can serve as molecular markers for improved @entity1 management and survival. To this end, epithelial-mesenchymal transition (EMT) is a major process that promotes @entity5 invasion and @entity3 , making EMT-related proteins attractive diagnostic biomarkers and therapeutic targets. In this study, we used immunohistochemistry to study the expression of a panel of transcription factors ( @entity8945 , @entity72699 , @entity18075 and @entity18436 ) and other genes intimately related to EMT ( @entity5962 and @entity13938 ) at the invasive @entity5 front of @entity957 tissues. The association between the expression of these proteins and clinico-pathological parameters were examined with Pearson Chi-square and correlation with survival was analyzed using Kaplan Meier analysis. Our results demonstrate that there was a significant differential expression of @entity5962 , @entity13938 , @entity72699 and @entity8945 between @entity957 and normal oral mucosa (NOM). Specifically, @entity5962 loss was significantly associated with Broder's grading, while diffused @entity13938 was similarly associated with non-cohesive pattern of invasion. Notably, co-expression of @entity8945 and @entity18436 in @entity957 was significantly associated with poorer overall survival, particularly in @entity1 without detectable lymph node @entity3 . This study demonstrates that EMT-related proteins are differentially expressed in @entity957 and that the co-expression of @entity8945 and @entity18436 could be of clinical value in identifying @entity1 with poor survival for appropriate @entity1 management.
