Liver angiotensinogen synthesis and release during @entity3371 treatment in @entity1372 -depleted XXXX .

@entity4689 @entity3371 @entity1372 @entity3449 @entity35
In vivo generation of angiotensins depends upon both plasma @entity3449 and angiotensinogen concentrations. Those factors which may influence hepatic angiotensinogen synthesis and release were examined. We have evaluated in vivo the effects of converting enzyme inhibition on several plasma @entity3449 -angiotensin system components, and, using an in vitro preparation of liver slices, we also investigated the effects of converting enzyme inhibition on the synthesis and release of hepatic angiotensinogen. Angiotensinogen concentrations were determined by two different methods. The first was an indirect enzymatic assay which measures the amount of @entity4689 liberated from plasma by an excess of @entity3449 . The second was a direct RIA that measures both angiotensinogen and its inactive residue the des- @entity4689 -angiotensinogen. The difference between the methods represents the circulating levels of des- @entity4689 -angiotensinogen. @entity3371 administration in @entity1372 -depleted @entity35 increased plasma concentrations of @entity3449 , des- @entity4689 -angiotensinogen, and @entity4689 and decreased plasma angiotensinogen concentration measured by both methods. Plasma des- @entity4689 -angiotensinogen was significantly correlated to plasma @entity3449 concentration, which suggests an increase in the consumption of angiotensinogen when the @entity3449 secretion is extremely increased. The angiotensinogen liver content and in vitro angiotensinogen release were decreased in @entity1372 -depleted @entity35 treated with a converting enzyme inhibitor, and these parameters were negatively correlated to in vivo plasma levels of @entity3449 , @entity4689 , and des- @entity4689 -angiotensinogen. They were positively correlated to plasma angiotensinogen concentration measured by the indirect assay. These data suggest that @entity3371 administration during @entity1372 depletion has two simultaneous effects: it increases angiotensinogen consumption and second, decreases angiotensinogen production and release.
