Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a XXXX outpatient sample.

@entity1262 @entity308 @entity8991 @entity7657 @entity9021 @entity903 @entity13783 @entity72695 @entity2339 @entity13784 @entity906
AIMS: This study investigated clinical and genetic predictors of increasing suicidal ideation during antidepressant treatment. MATERIALS _ METHODS: A total of 131 @entity308 outpatients were allocated to four antidepressants ( @entity903 , @entity906 , @entity8991 or @entity9021 ) in a sequential step procedure until remission. Suicidality was assessed using the 10th item of the Montgomery-Asberg Depression Rating Scale (MADRS). A total of 11 candidate genes involved in different mechanisms of antidepressant action were selected for association with increasing suicidality. RESULTS: Increasing suicidality correlated with @entity308 severity and higher antidepressant blood levels. Risk of increasing suicidal ideation was higher in subjects taking antidepressants other than @entity903 (odds ratio: 1.11). The strongest genetic predictor was found to be @entity13783 within the @entity13784 gene (p = 2.9   10(-5)), followed by @entity7657 in the @entity1262 gene. The @entity72695 SNP within the 5-HTR1B gene demonstrated a differential association with increasing suicidal ideation depending on antidepressant type. CONCLUSION: Increasing suicidal ideation might be an adverse effect of antidepressants. The involvement of @entity13784 indicates that dysregulation of the @entity2339 is involved in treatment increasing suicidal ideation.
