Assessment of XXXX using self-report and caregiver report: a multicentre validation study.

@entity1 @entity483 @entity2286 @entity484
BACKGROUND: The epidemiology of @entity483 ( @entity483 ) in the U.S.A. has been described largely via US population-based questionnaire studies. However, the validity of the questions used for self- and caregiver-reported @entity484 has not been previously demonstrated. OBJECTIVES: To validate the assessment of self- and caregiver-reported @entity484 . METHODS: We performed a prospective multicentre dermatology-practice-based study (three sites) to determine the validity of caregiver- and self-reported ever having @entity484 and 1-year history of @entity484 . Questionnaires were administered to unselected @entity1 prior to their encounter. @entity1 (n = 782) were then evaluated by expert dermatologists trained in utilizing the Hanifin and Rajka criteria for @entity483 . Sensitivity, specificity, positive predictive value ( @entity2286 ) and negative predictive value were determined. RESULTS: Caregiver-reported 1-year history of childhood @entity484 was found to have a sensitivity (95% confidence interval) of 0  70 (0  59-0  80), specificity of 0  96 (0  93-0  99) and @entity2286 of 0  87 (0  78-0  96) when compared with a physician's diagnosis of @entity483 at that visit. Similarly, self-reported 1-year history of adult @entity484 was found to have a sensitivity of 0  70 (0  59-0  80), specificity of 0  95 (0  93-0  97) and @entity2286 of 0  76 (0  64-0  85). The specificities and PPVs of a history of ever having caregiver- (0  89, 0  82-0  96 and 0  81, 0  70-0  93) and self-reported @entity484 (0  97, 0  95-0  99 and 0  91, 0  85-0  97) were high, with a high sensitivity in @entity1 (0  83, 0  72-0  95) but not in adults (0  43, 0  37-0  51). CONCLUSIONS: Self- and caregiver-reported diagnosis of @entity484 ever or in the past year based on a single question demonstrates sufficient validity for the epidemiological study of @entity483 .
