[Preclinical toxicological study of the new antibiotic XXXX . Chronic @entity137 and effect on intrauterine development of @entity35 ].

@entity1 @entity137 @entity1133 @entity235 @entity840 @entity35 @entity493 @entity73332
@entity137 of @entity73332 was studied after its multiple parenteral administration to albino @entity35 , @entity840 and @entity235 in doses equivalent by the body surface to the daily doses for @entity1 i. e. 1 and 3 g. The antibiotic was administered for 1 to 6 months. Tolerance of the antibiotic by the @entity235 after intravenous and intramuscular administration was satisfactory. In some animals there were observed an insignificant increase in the activity of @entity493 aminotransferase and a rise in the level of @entity1133 in blood serum. Pathomorphological examination of the internal organs of the albino @entity35 and @entity235 showed that in high doses the antibiotic could have a damaging effect on the kidneys and epithelium of the gastrointestinal tract. The level of the damages depended on the dose of the antibiotic and duration of its use. The damages induced by @entity73332 were reversible. It had no marked effect on the peripheral blood count, coagulation system and erythrocyte resistance. In the tested doses the antibiotic had no unfavourable effect on the hearing function in the experiments with @entity840 . Studies with @entity35 revealed that @entity73332 had no teratogenic effect. A slightly pronounced embryotoxic action was observed only after using the antibiotic in doses exceeding more than 12 times the approximate therapeutic dose.
