Differential expression of XXXX and @entity3546 in primary and metastatic @entity3969 .

@entity5 @entity5962 @entity189 @entity3546 @entity3969
BACKGROUND: The @entity5962 -catenin adhesion complex is crucial for intercellular adhesiveness and maintenance of tissue architecture. Its impairment is associated with poorly differentiated phenotype and increased invasiveness of @entity189 . AIMS: To evaluate @entity5962 , @entity3546 , gamma catenin, and ezrin expression and its relation to histopathological features of primary and metastatic @entity3969 . METHODS: Immunohistochemistry was used to determine the expression and cellular distribution of @entity5962 , @entity3546 , gamma catenin, and ezrin in primary and metastatic @entity3969 . Western blotting was used to determine polypeptide size and expression of @entity5962 and @entity3546 in @entity3969 compared with normal kidney. RESULTS: Moderate expression of @entity5962 was found mainly in cytoplasm and occasionally cell membranes of dysplastic tubules, whereas low expression was seen in cytoplasm of blastemal cells. Primary and @entity5 showed moderate to high @entity3546 expression in blastemal and epithelial cells, with predominantly membranous and cytoplasmic staining. Occasional nuclear staining was noted in @entity5 . Low to high gamma catenin and ezrin expression was seen in cytoplasm of blastemal and epithelial cells of primary and @entity5 . Higher amounts of 92 kDa @entity3546 were detected in @entity5 than in normal kidney. Low expression of 120 kDa @entity5962 was seen in moderately differentiated @entity5 , whereas expression was lacking in poorly differentiated @entity5 . CONCLUSIONS: Compared with primary @entity5 , @entity5 showed lower expression of @entity5962 and gamma catenin, with nuclear staining for @entity3546 . Low @entity5962 was associated with poorly differentiated @entity5 . These results suggest that abnormal expression of adhesion proteins correlates with the invasive and metastatic phenotype in @entity3969 .
