Oxidative Stress Markers and Histological Analysis in Diverse Organs from @entity35 Treated with a Hepatotoxic Dose of XXXX : Effect of @entity6108 .

@entity137 @entity24234 @entity6596 @entity2041 @entity6108 @entity6172 @entity1234 @entity12609 @entity35 @entity224 @entity1865
@entity6596 [ @entity6596 ] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about @entity6596 @entity137 , the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that @entity6108 prevents hepatotoxicity induced by a single intraperitoneal injection of 15  mg/kg body weight (b.w.) of @entity24234 ( @entity24234 ). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from @entity35 treated with a hepatotoxic dose of @entity24234 (15  mg/kg b.w.), and the effect of @entity6108 pretreatment. @entity35 were divided into four groups: control, @entity6108 , @entity24234 , and @entity6108 + @entity24234 . At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. @entity24234 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of @entity1234 ( @entity1865 ), @entity2041 ( @entity6172 ), and the activity of @entity224 dismutase (SOD), @entity12609 ( @entity12609 ), and related @entity6172 enzymes were unchanged. As expected, @entity6108 was safe. Lack of @entity24234 -induced @entity137 in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15  mg/kg of @entity24234 , that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.
