Predicting XXXX from hypothalamic-pituitary-adrenal axis functioning: a 3-year follow-up in the TRAILS study.

@entity1 @entity308 @entity146 @entity1316 @entity148 @entity13754 @entity74 @entity701
BACKGROUND: Hypothalamic-pituitary-adrenal axis functioning, with @entity701 as its major output hormone, has been presumed to play a key role in the development of psychopathology. Predicting @entity1316 from diurnal @entity701 levels has been inconclusive, whereas the predictive value of stress-induced @entity701 concentrations has not been studied before. The aim of this study was to predict @entity146 over a 3-year follow-up from awakening and stress-induced @entity701 concentrations. METHOD: Data were used from 561 TRAILS (TRacking Adolescents' Individual Lives Survey) @entity1 , a prospective cohort study of Dutch adolescents. Saliva samples were collected at awakening and half an hour later and during a social stress test at age 16. @entity146 were assessed 3 years later with the Composite International Diagnostic Interview (CIDI). RESULTS: A lower @entity701 awakening response (CAR) marginally significantly predicted @entity74 [odds ratio (OR) 0.77, p  =  0.06]. A flat @entity74 with a first onset after the experimental session (OR 1.27, p  =  0.04). Recovery revealed smaller, non-significant ORs when predicting new onset affective or @entity148 , major @entity308 , or @entity13754 in three separate models, corrected for all other new onsets. CONCLUSIONS: Our results suggest that delayed recovery and possibly reduced CAR are indicators of a more general risk status and may be part of a common pathway to psychopathology. Delayed recovery suggests that individuals at risk for @entity146 perceived the social stress test as less controllable and less predictable.
