Dose-response relationship between cigarette smoking and female XXXX .

@entity1 @entity1239 @entity458 @entity250
OBJECTIVE: To evaluate whether smoking is a risk factor for female @entity250 (FSD) and to determine the relationship between the cumulative smoking dose and FSD in premenopausal @entity1 . METHODS: The study population consisted of sexually active premenopausal @entity1 . The frequency of FSD and @entity458 ( @entity458 ) total score were evaluated according to the smoking status (never/former and current smokers). Evaluation of sexual function was done using @entity458 questionnaire, and @entity1 with @entity458 score of  <=26.55 were considered to have FSD. In current smokers, sexual function was also evaluated according to the cumulative smoking dose and @entity1239 dependency. RESULTS: A total of 900 @entity1 were included, and the frequency of current smokers and the frequency of FSD were 62 (6.9%) and 496 (55.1%), respectively. In current smokers, the frequency of FSD was significantly higher and the median total @entity458 score was significantly lower than in never/former smokers, and this difference of FSD remained significant after adjustment for confounding variables. Among current smokers, the cumulative smoking dose (pack-years) and the total @entity458 score showed negative correlation, in which increased cumulative smoking dose was associated with lower total @entity458 score (r=-0.278, P<0.05). In terms of @entity1239 dependency, the total @entity458 score of moderately to heavily @entity1239 dependent smokers was significantly lower than that of lightly dependent smokers. CONCLUSION: In premenopausal @entity1 , current smoking was an independent risk factor for FSD. And cumulative smoking dose and @entity1239 dependency were associated with higher risk of FSD.
