Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in XXXX @entity1 .

@entity1 @entity64 @entity6826 @entity5439 @entity7 @entity2295 @entity62202 @entity319 @entity2280 @entity385
BACKGROUND AND PURPOSE: Endothelial progenitor cells (EPC) are important @entity1 of @entity2295 and are mobilized through signaling with stromal-derived factor (SDF-1a), @entity7 ( @entity7 ), @entity62202 . The association between EPC levels and these growth factors (GF) in @entity64 has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and @entity64 severity in @entity64 @entity1 . METHODS: Seventeen @entity1 were selected from 175 @entity1 with imaging-confirmed acute @entity385 . EPC were quantified using @entity2280 , @entity5439 , and @entity319 markers. Plasma @entity7 , SDF-1a, @entity62202 were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the @entity64 onset. RESULTS: Levels of SDF-1a strongly (r=0.6) correlated with the numbers of EPC subsets @entity5439 (+)VEFG-R2(+) (P<0.004), @entity2280 (+) @entity7 -R2(+) (P<0.01), and @entity2280 (+) @entity5439 (+) @entity7 -R2(+) (P<0.01) on day 1. @entity6826 strongly (r=0.5) correlated with @entity5439 (+) @entity7 -R2(+) (P<0.05). SDF-1a moderately inversely (r=-0.49) correlated with baseline diffusion-weighted imaging lesion volumes (P<0.04). Median levels of SDF-1a (1561 pg/mL) increased (P<0.04) on day 3 compared to day 1 (1379 pg/mL). Similarly, @entity7 at day 3 (95 pg/mL) increased (P<0.03) compared to day 1 (64 pg/mL). CONCLUSIONS: These results indicate that SDF-1a and @entity6826 correlate with an increase in EPC early in @entity385 @entity1 .
