Causative factors in the etiology of peptic XXXX disease become effective before the age of 15 years.

@entity1066 @entity204 @entity2275
Peptic @entity1066 in Western Europe, Japan, and the United States is characterized by marked temporal changes which suggest that environmental factors are important in the etiology of @entity2275 . The present study examines at what age these factors start becoming effective. When the average age-specific death rates from 18 countries are plotted vs the year of birth, the fall of @entity2275 mortality related to successive birth-cohorts is continuously preserved in the age group of 15-19 years. Although the younger age groups also display a decline in @entity1066 , it is not possible to discern unequivocally whether they follow the temporal pattern of birth-cohort risks. In the second analysis, the number of @entity204 from each individual country is accumulated over time, and the geographic variation in the age-specific mortality is compared for these countries. The death rates of consecutive age groups from different countries change in a parallel manner. The linear relationships between each two consecutive age groups start at the age of 5 years in @entity2275 and at the age of 15 years in duodenal @entity1066 . These findings again suggest that the determinants for the risk of dying from @entity2275 begin to act at an age lower than 15. The contention of environmental factors starting to act before the age of 15 would remain valid, even if factors unrelated to etiology, such as different reporting for childhood and adult mortality, contributed to the different patterns of childhood and adult death rates. However, the actual cut-off age of @entity2275 would then be shifted towards younger ages.
