Expression of HLA-DR antigens on bile duct epithelium in XXXX .

@entity1 @entity2835 @entity991 @entity409 @entity99
The expression of HLA class I (HLA-A, B, C) and class II (HLA-DR) antigens on the biliary epithelium of 10 @entity1 (nine @entity1 ) with @entity991 ( @entity991 ) was investigated using an immunoperoxidase technique on cryostat sections. Five @entity1 were staged as grade II and five grade III on hepatic histology. None were cirrhotic. as grade II and five grade III on hepatic histology. None were cirrhotic. Controls were nine @entity1 with @entity2835 ( @entity2835 ), five with extra @entity99 , 15 with other forms of @entity409 and six with normal livers. Bile ducts from the normal subjects and @entity1 with @entity409 did not express HLA-DR antigens. In contrast, all 10 of the @entity991 biopsies showed varying degrees of HLA-DR staining of the biliary epithelium. Expression of DR antigens was also found on the bile ducts of all five @entity1 with extra @entity99 and in six of nine @entity1 with @entity2835 . Expression of HLA class I antigens was seen on the biliary epithelium of all the biopsies examined. Increased numbers of helper and suppressor T-cells were seen in the portal tracts of all the @entity991 @entity1 . This study has confirmed that aberrant expression of HLA-DR may occur on the biliary epithelium of some, but not all, @entity1 with @entity2835 . In addition, the study has shown that aberrant expression of HLA-DR always occurs in PCS at an early stage of histological @entity409 . While this may be important in the pathogenesis of @entity991 , the aberrant expression in extra @entity99 suggests that it may be a secondary phenomenon.
