Prospective evaluation of the effect of an @entity1289 gene polymorphism on the long term risk of major adverse XXXX after percutaneous coronary intervention.

@entity1 @entity1289 @entity583 @entity6 @entity301 @entity1459 @entity299 @entity453 @entity204
OBJECTIVE: To evaluate prospectively the influence of an @entity1289 ( @entity1289 ) gene polymorphism on long term clinical outcome of @entity1 with established @entity453 treated by percutaneous coronary intervention. DESIGN AND SETTING: Prospective observational study in a university hospital. @entity1 : Consecutive series of 1010 @entity1 with symptomatic @entity453 who underwent successful coronary stent placement from November 1996 to April 1998. MAIN OUTCOME MEASURES: Long term clinical outcome was obtained and the rates of major adverse @entity299 ( @entity204 , non-fatal @entity583 , @entity1459 , and revascularisation) were compared according to the insertion/deletion (I/D) polymorphism of the @entity1289 gene. RESULTS: Of the 1010 @entity1 29% had the DD genotype, 51% had the ID genotype, and 20% had the II genotype. All baseline clinical angiographic and procedural characteristics were identical in the three groups of @entity1 . Event-free survival during the follow up period (median two years) was identical in @entity1 with the II genotype compared to those with one or two D alleles. The predictors of long term survival were age, @entity6 , ejection fraction, and extension of @entity453 . @entity1289 genotype had no influence on the long term survival. Additional analyses assuming dominant and recessive effects of the D allele also failed to find any association; nor did the examination of low risk subgroups. CONCLUSIONS: The @entity1289 I/D polymorphism does not influence the long term prognosis of @entity1 with @entity301 treated by percutaneous coronary intervention, and screening @entity1 for this gene polymorphism is not useful for secondary prevention strategies.
