Dual effects of @entity1 adipose tissue-derived mesenchymal stem cells in XXXX lung adenocarcinoma A549 xenografts and colorectal adenocarcinoma HT-29 xenografts in @entity19 .

@entity1 @entity9135 @entity101 @entity19 @entity5 @entity27863
@entity1 adipose tissue-derived mesenchymal stem cells (hATMSCs) have great potential as a therapy for various diseases. However, emerging evidence shows that there are conflicting results concerning effects of hATMSCs on @entity5 progression. Our objective was to determine whether and how hATMSCs modulate @entity5 growth. After @entity5 cell lines were subcutaneously inoculated into BALB/c-nude and hairless severe combined immunodeficient @entity19 , hATMSCs were intratumorally injected into the @entity19 . The growth of the @entity5 was inhibited by hATMSCs, yet that of the @entity101 was significantly promoted by hATMSCs in the in vivo xenograft models. In vitro study using a co-culture system of @entity5 cells and hATMSCs was consistent with the in vivo experiments. To reveal the molecular events induced by hATMSCs in the xenograft models, global gene expression profiles of the A549 and @entity101 in the absence or presence of hATMSCs were determined. Significant numbers of genes involved in biological processes were altered in the hATMSC-treated @entity5 , whereas no biological process was regulated by treatment with hATMSCs in the @entity101 , reflecting the different effects of hATMSCs in the different types of @entity5 . Notably, histone cluster 1, H2aj and @entity27863 were found to be expressed in direct or inverse proportion to @entity5 size in both xenograft models. In addition, nuclear factor kB (NF-kB) @entity9135 was differentially phosphorylated by the hATMSCs dependent on the source of the @entity5 cells. In conclusion, the identified gene profiling and NF-kB signaling provide molecular evidence to explain the conflicting findings in @entity5  -MSC studies, although further study is needed to confirm these findings using various types of @entity5 .
