Combined intraarterial and intravenous thrombolysis for severe XXXX .

@entity1 @entity50 @entity772
To investigate the safety and efficacy of endovascular therapy with combined intra-arterial and intravenous thrombolysis for severe @entity50 . Of the 28 consecutive @entity1 with @entity50 admitted to our hospital in recent 3 years, six @entity1 underwent combined intra-arterial and intravenous thrombolysis. For each @entity1 , local contact thrombolysis was performed with balloon catheter to break clot and urokinase infused for thrombolysis in sinus. At the same time, urokinase (100,000 IU/h) was infused intra-arterially via internal carotid artery to dissolve the venous thrombi. Neurologic outcomes, Glasgow @entity772 scale (GCS), neuroimaging results and modified Rankin Scale score (mRS) were recorded. Of the six treated @entity1 , two were males and four females. Their mean age was 38 +/- 13 (range from 22 to 57) years. Completely recanalization was observed in five @entity1 , whose clinical symptoms recovered completely (mRS score 0). One @entity1 in whom thrombolysis was delayed died the day after the procedure. Endovascular treatment with combined intra-arterial and intravenous thrombolysis may improve neurological outcomes of severe @entity50 .
