Telomere XXXX occurs early during gastrocarcinogenesis.

@entity1 @entity5 @entity3207 @entity1344 @entity356
When telomeres are shortened to a critical length, they will initiate @entity1344 ( @entity1344 ) and may finally cause tumorigenesis. The purpose of the present study was to evaluate the shortened telomere as a potential biomarker for tumorigenesis in @entity356 . The telomeres in matched @entity5 and adjacent noncancer mucosa samples from 86 @entity356 @entity1 were measured by real-time polymerase chain reaction (PCR). According to the International Union Against @entity5 (UICC), @entity5 stages were classified into four groups: stage I (n = 23), stage II (n = 20), stage III (n = 23), and stage IV (n = 20). Telomere length decreased with aging in both adjacent noncancer mucosa and @entity5 tissue (r = -0.261 (P = 0.008) and r = -0.27 (P = 0.012), respectively). The telomere length of UICC stage I @entity5 was significantly shorter than the average telomere length in adjacent noncancer mucosa (P = 0.023). Telomere length increased gradually with increasing UICC stage (P = 0.032). The telomere length of UICC stage IV @entity5 was significantly longer, when compared to that in noncancer mucosa (P = 0.019) and stage I @entity5 (P = 0.002). In summary, telomere length undergoes @entity3207 in early stage @entity356 and lengthening in advanced @entity356 . Additionally, telomere @entity3207 may initiate the tumorigenesis of @entity356 .
