Effects of heparin fractions on the prevention of XXXX resulting from @entity632 extravasation: an experimental study.

@entity1 @entity632 @entity548 @entity39 @entity5 @entity16960 @entity1066 @entity1372 @entity460 @entity35 @entity2332
Extravasation of a chemotherapeutic agent is one of the most frequent complications in @entity5 @entity1 . Full-thickness @entity39 often occurs after extravasation. Alternative approaches to treatment are local wound care, elevation, and @entity2332 . It was shown that heparin prevents @entity39 . In this experimental study, the effects of heparin fractions on the prevention of @entity39 were compared by applying an extravasation model of @entity632 in @entity35 . Forty Sprague-Dawley male @entity35 weighing 250 to 300 g were used. A total of 0.3 ml @entity632 was administered subcutaneously to all @entity35 . Ten minutes later, in the control group (group I), 1 ml normal saline was administered subcutaneously. In the first experimental group (group II), 100 U per day heparin @entity1372 was administered in a volume of 1 ml subcutaneously. In the second experimental group (group III), nadroparin @entity460 (5 anti-Xa U per kilogram per day) was administered. In the third and last experimental group (group IV), @entity16960 (5 anti-Xa U per kilogram per day) was administered. All drugs were administered for 2 weeks. Necrotic areas were measured 4 weeks later. Statistical analysis was performed using the Kruskal-Wallis analysis of variance and the Mann-Whitney test. Heparin fractions caused a decreased @entity1066 rate and size than controls ( < 0.05). There was no superiority among heparin fractions. The authors think that low-molecular weight heparins are preferred, considering the higher risk of @entity548 with unfractionated heparin.
