Elevated exhalation of hydrogen peroxide in @entity1 with XXXX .

@entity1 @entity274 @entity229 @entity26 @entity786 @entity7087 @entity785
BACKGROUND: @entity785 is accompanied by an influx of activated phagocytes into distal airways. These cells release @entity274 , which may evaporate from the airways surface and be detected in expired breath condensate. We tested whether @entity1 with @entity785 exhale more @entity274 than healthy subjects and whether breath condensate @entity274 levels correlate with some clinical parameters. MATERIAL AND METHODS: @entity274 was measured fluorimetrically in the expired breath condensate of 27 @entity1 (22 @entity1 , five @entity1 , mean age 49 +/- 13.1 years) with @entity785 and 27 age- and sex- matched healthy controls. RESULTS: Exhaled @entity274 levels were 3.5-fold higher (0.88 +/- 0.62 microM vs. 0.25 +/- 0.17 microM, P < 0.001) in the @entity1 with @entity785 than in the controls. Treatment with @entity786 and/or @entity229 (29 +/- 50 months, range 3-168 months) did not significantly decrease @entity274 exhalation (0.78 +/- 0.50 microM, n= 10 vs. 0.94 +/- 0.67 microM, n= 17, P > 0.05). No significant difference was found between @entity1 with limited and @entity7087 (1.03 +/- 0.69 microM, n= 17 vs. 0.63 +/- 0.41 microM, n= 10, P > 0.05). @entity274 levels correlated with disease duration (r = 0.38, P < 0.05) and time from the first Raynaud's episode (r = 0.44, P < 0.05). CONCLUSIONS: @entity1 with @entity785 exhale more @entity274 than healthy controls, suggesting involvement of reactive @entity26 species in disease processes. Lack of significant intergroups differences in @entity274 levels may have resulted from the small number of @entity1 analyzed.
