@entity20667 suppressed irradiation-resistant XXXX stem cells by modulating @entity1477 / @entity16106 @entity2270 .

@entity1 @entity1477 @entity5439 @entity5 @entity19 @entity11 @entity3546 @entity16106 @entity20667 @entity2270 @entity157 @entity463
UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .
