XXXX -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J @entity19 .

@entity1 @entity131 @entity19 @entity73 @entity4176 @entity1315 @entity148 @entity302 @entity159
@entity1 with mesial @entity1315 (mTLE) frequently show @entity73 . However, the relation between mTLE and @entity73 is poorly understood. To gain more insight into @entity302 -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J @entity19 five weeks after @entity4176 -induced @entity159 ( @entity159 ). Typically, structural hippocampal rearrangements take place within five weeks after @entity159 . @entity19 were monitored by exposing them to four tasks with a focus on spatial memory and @entity148 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after @entity159 . In contrast, no change in strategy was seen on the modified hole board, but animals with @entity159 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after @entity159 . No indications for altered @entity148 were found when tested on the elevated plus maze following @entity159 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle @entity159 -induced @entity131 .
