Heritability of Risk for Sudden Cardiac Arrest in XXXX .

@entity1 @entity454 @entity1167
UNASSIGNED: @entity1 on dialysis are 20 times more likely to have a @entity1167 compared with the general population. We considered whether inherited factors associate with @entity1167 among @entity1 on dialysis. From a sample of 647,457 @entity1 on chronic dialysis, we identified 5117 pairs of @entity1 who came from the same family. These @entity1 were each matched to a control subject from the same population. McNemar's tests were used to compare the risk of @entity1167 between the familial related and unrelated pairs. Genetically related family members who did not cohabitate had an odds ratio of 1.88 (95% confidence interval [95% CI], 1.25 to 2.84) for @entity1167 compared with their phenotypically matched unrelated controls. Genetically related family members who lived together in the same environment had an odds ratio of 1.66 (95% CI, 1.20 to 2.28). Spouses, who are genetically unrelated but live together in the same environment, had an odds ratio of 0.95 (95% CI, 0.60 to 1.59) for @entity1167 . The risk of @entity1167 in @entity1 on dialysis may be attributable to inherited factors. Additional studies are needed to identify such candidate genes that modify cardiovascular risk in @entity454 .
