Cytological Scoring and Prognosis of Poorly Differentiated XXXX .

@entity5 @entity1 @entity4348 @entity3
OBJECTIVE: Histopathological variation has been demonstrated in grade 3 @entity4348 . We attempted to evaluate the clinicopathological features of grade 3 @entity5 by endometrial cytological features using a scoring system. STUDY DESIGN: Twenty-one endometrial cytological samples were evaluated using 5 cytological features: rates of cluster formation in @entity5 cells; nuclear pleomorphism; nuclear dimension; size of nucleoli, and chromatin structure and distribution. The relationships between cytological scores and clinicopathological factors or prognosis were investigated. RESULTS: The median cytological score was 6 (range 4-14); therefore, samples with scores of 4-5 were defined as having low scores, while those with scores of 6-14 were defined as high scores. The accuracy of the cytological diagnosis for grade 3 @entity5 in the high score group (8/10 @entity1 , 80.0%) was significantly higher than that of the low score group (2/11 @entity1 , 18.2%; p = 0.009). Significant relationships between cytological scores and lymph node @entity3 or positive peritoneal cytology were observed (p = 0.03 and 0.035, respectively). The overall survival rate was significantly worse in the high score group (30.0%) than the low score group (88.9%; p = 0.02). CONCLUSIONS: Grade 3 @entity4348 varied in cytological features; according to the scoring system used, high scores were associated with worse clinicopathological factors and poorer prognosis than low scores.    2015 S. Karger AG, Basel.
