Lipid metabolism and XXXX signaling pathways participate in late-phase liver regeneration.

@entity3725 @entity844 @entity409 @entity35 @entity62705
@entity409 ( @entity409 ) is of great clinical significance in various liver-associated diseases. @entity409 proceeds along a sequence of three distinct phases: priming/initiation, proliferation, and termination. Compared with the recognition of the first two phases, little is known about @entity409 termination and structure/function reorganization. A combination of "omics" techniques, along with bioinformatics, may provide new insights into the molecular mechanism of the late-phase @entity409 . Gene, protein, and metabolite profiles of the @entity35 liver were determined by cDNA microarray, two-dimensional electrophoresis, and HPLC-MS analysis. Pathway enrichment analysis was performed to identify the pathways: 427 differentially expressed genes extracted from the microarray experiment revealed two expression patterns representing the early and late phase of @entity409 . Functionally, the genes expressing at a higher level at the early phase than at the late phase were mainly involved in the response to stress, proliferation, and resistance to apoptosis, while those expressing at a lower level at the early phase than at the late phase were mainly engaged in lipid metabolism. Compared with the sham-operation control (SH) group, 5 proteins in the 70% partial hepatectomy (70%PHx) group were upregulated at the protein level, and 3 proteins were downregulated at 168 h after the 70%PHx. @entity62705 , an upregulated @entity844 binding protein, was found to be involved in the @entity3725 ( @entity3725 ) signaling pathway. The metabolomic data confirmed the enhancement of lipid metabolism by the detection of the intermediate and final metabolites. We've concluded that increased lipid metabolism and activated @entity3725 signaling pathways play important roles in late-phase @entity409 .
