Clinical implication of plasma natriuretic peptides in @entity1 with XXXX .

@entity1 @entity3876 @entity120 @entity1757 @entity358
BACKGROUND: There is little information available concerning plasma concentrations of @entity3876 ( @entity3876 ) in @entity1 with a @entity1757 . The aim of the present study was to determine hemodynamic factors that control plasma concentrations of @entity3876 and the clinical implications of @entity3876 compared with atrial natriuretic peptide (ANP) in @entity1 with @entity1757 . METHODS: Fifty-nine @entity1 with @entity1757 (28 @entity1 and 31 @entity1 ) without @entity358 were enrolled. The @entity1 ' ages ranged from 3 months to 13 years (mean 3.1 years). Plasma @entity3876 and ANP were determined by immunoradiometric assay. Hemodynamic variables derived from cardiac catheterization were analyzed in terms of correlation with @entity3876 and ANP. RESULTS: It was found that plasma @entity3876 significantly positively correlated with ANP (ANP = 2.1 x @entity3876 + 25 pg/mL; r = 0.81, P < 0.0001) and @entity3876 never exceeded ANP in the present @entity1 series. Plasma @entity3876 as well as ANP significantly positively correlated with pulmonary to systemic flow ratio (r = 0.65 and r = 0.59, respectively) and mean pulmonary artery pressure (r = 0.72 and r = 0.68, respectively). In addition, plasma @entity3876 of > or =20 pg/mL and ANP of > or =50 pg/mL identified @entity1 with mean pulmonary artery pressure of > or =20 mmHg with a sensitivity of 82% and 97%, respectively, and a specificity of 89% and 84%, respectively. CONCLUSION: Plasma @entity3876 and ANP reflect pressure and volume loads to the pulmonary artery and right ventricle and may help to identify @entity1 with @entity1757 complicated by @entity120 that demands early intervention.
