Optimizing Prelemniscal Radiations as a Target for Motor Symptoms in XXXX Treatment.

@entity400 @entity2003 @entity191
OBJECTIVE: To better define prelemniscal radiations (Raprl) as a target for the control of @entity400 and @entity2003 in @entity191 ( @entity191 ). METHODS: A total of 36 deep brain stimulation (DBS) electrodes were stereotactically implanted in Raprl contralateral to the extremities to be treated. Effects on symptoms were evaluated using UPDRS-III before and after DBS, and significance was determined using the Wilcoxon test. The location of DBS contacts in cases with optimum versus suboptimum results was evaluated using Student's t test and percentage improvement correlated through a bivariable Pearson test. The power and percentage of spike components for microelectrode recordings were statistically compared between the target point and structures located above and below. RESULTS: Raprl-DBS improved @entity400 and @entity2003 (p < 0.01). The potency of microelectrode recordings indicated that the target was formed by fibers. There was no correlation between demographic characteristics and clinical outcome, and there were no significant differences in stereotactic placement between cases with optimum and suboptimum results. @entity400 and @entity2003 were selectively improved in cases with suboptimum results. CONCLUSION: Raprl-DBS is an effective treatment for the motor symptoms of @entity191 . Selective improvement of symptoms suggests that the target has different fiber components related to either @entity400 or @entity2003 , and variations in improvement between cases may derive from individual variations of the location of these fibers.    2015 S. Karger AG, Basel.
