XXXX Supplementation Attenuates Oxidative Stress and Improves Vascular @entity6306 in @entity3883 .

@entity6306 @entity3883 @entity648 @entity2041 @entity1505 @entity6172 @entity29101 @entity3426 @entity3612 @entity3451 @entity35 @entity1865
We investigated the protective effects and mechanism of @entity2041 ( @entity6172 ) on vascular @entity6306 induced by bile duct ligation (BDL) in a @entity35 model. Seventy-two male @entity35 were randomly divided into four groups: a NS group, a @entity6172 group, a BDL + NS group, and a BDL + @entity6172 group. @entity6172 was administrated into @entity35 in the @entity6172 and BDL + @entity6172 groups by gastric gavage. An equal volume of normal saline was, respectively, given in the NS group and BDL + NS group. Blood was gathered for serological determination and thoracic aorta rings were isolated for measurement of isometric tension. @entity3883 led to a significant increase in the serum total @entity648 , AST, and ALT levels. The proinflammatory cytokines levels ( @entity1505 and @entity3426 ), concentration of NO, and oxidative stress markers ( @entity1865 and 3-NT) were increased as well. All of those were reduced by the treatment of @entity6172 . Meanwhile, contraction of aorta rings to NA and vasorelaxation to @entity3451 or SNP in the BDL group @entity35 were markedly decreased, while @entity6172 administration reversed this change. Our findings suggested that @entity6172 supplementation attenuated overexpressed @entity29101 from the reaction of excessive NO with @entity3612 (   -) and protected against @entity3883 -induced vascular @entity6306 in @entity35 .
