Impact of fecal occult blood on obscure XXXX : observational study.

@entity1 @entity548 @entity5 @entity1066 @entity29 @entity1503 @entity360
AIM: To elucidate the association between @entity29 ( @entity29 ) and positive @entity1503 ( @entity1503 ) in @entity1 with obscure @entity360 (OGIB). METHODS: Between February 2008 and August 2013, 202 @entity1 with OGIB who performed both capsule endoscopy (CE) and @entity1503 were enrolled (mean age; 63.6    14.0 years, 118 males, 96 previous overt @entity548 , 106 with @entity548 ). All @entity1 underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on @entity1503 results. The prevalence of @entity29 was compared between @entity1 with positive and negative @entity1503 . RESULTS: CE revealed @entity29 in 72 @entity1 (36%). @entity1503 was positive in 100 @entity1 (50%) and negative in 102 (50%). The prevalence of @entity29 was significantly higher in @entity1 with positive @entity1503 than those with negative @entity1503 (46% vs 25%, P = 0.002). In particular, among @entity1 with occult OGIB, the prevalence of @entity29 was higher in positive @entity1503 group than negative @entity1503 group (45% vs 18%, P = 0.002). On the other hand, among @entity1 with previous overt OGIB, there was no significant difference in the prevalence of @entity29 between positive and negative @entity1503 group (47% vs 33%, P = 0.18). In disease specific analysis among @entity1 with occult OGIB, the prevalence of @entity1066 and @entity5 were higher in positive @entity1503 group than negative @entity1503 group. In multivariate analysis, only positive @entity1503 was a predictive factors of @entity29 in @entity1 with OGIB (OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evident among @entity1 with occult OGIB who underwent @entity1503 on the same day or a day before CE. The prevalence of @entity29 in positive vs negative @entity1503 group were 54% vs 13% in @entity1 with occult OGIB who underwent @entity1503 on the same day or the day before CE (P = 0.001), while there was no significant difference between positive and negative @entity1503 group in those who underwent @entity1503 two or more days before CE (43% vs 25%, P = 0.20). CONCLUSION: The present study suggests that positive @entity1503 may be useful for predicting @entity29 in @entity1 with occult OGIB. Positive @entity1503 indicates higher likelihood of @entity1066 or @entity5 in @entity1 with occult OGIB. Undergoing CE within a day after @entity1503 achieved a higher diagnostic yield for @entity1 with occult OGIB.
