Intrathoracic @entity834 after XXXX resection is associated with increased risk of recurrence.

@entity1 @entity834 @entity5 @entity254 @entity189 @entity3
OBJECTIVE: Intrathoracic @entity834 after intended curative resection for @entity5 in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an @entity834 was associated with an increased recurrence rate. METHODS: This nationwide study included consecutively collected data on @entity1 undergoing curative surgical resection with intrathoracic @entity254 , alive 8 weeks postoperatively, between 2003 and 2011. @entity1 with incomplete resection, or metastatic disease intraoperatively, were excluded. Only biopsy-proven recurrences were accepted. RESULTS: In total, 1085 @entity1 were included. The frequency of @entity834 was 8.6%. The median follow-up time was 29 months (interquartile range [IQR]: 13-58 months). Overall, 369 (34%) @entity1 had disease recurrence, of which 346 @entity1 died of recurrent @entity189 . Twenty-three @entity1 were alive with recurrence at the censoring date. In the study period, 333 @entity1 died without signs of recurrent disease. The overall median time to recurrence was 66 weeks (IQR: 38-109 weeks). Distant @entity3 were found in 267 (25%), and local disease recurrence in 102 (9%) @entity1 . Overall, 5-year disease-free survival in @entity1 with leakage was 27%, versus 39% in those without leakage (P = .017). @entity834 was independently associated with higher risk of recurrence (hazard ratio [HR] = 1.63; 95% confidence interval [CI]: 1.17-2.29, P = .004) and all-cause mortality (HR = 1.57; 95% CI: 1.23-2.05, P < .0001). CONCLUSIONS: Intrathoracic @entity834 increased the risk of recurrence in @entity1 who underwent curative @entity5 resection.
