Spontaneous Bilateral Femoral Fractures After High-Dose XXXX .

@entity1 @entity5520 @entity158 @entity4381 @entity3330
The authors report a case of spontaneous bilateral diaphyseal femoral fractures believed to be caused by oversuppression of bone remodeling as a result of long-term, high-dose treatment with @entity5520 . The @entity1 reported @entity158 in both thighs before the fractures. Typical pathologic changes appeared on both femoral radiograph and bone scan before the fractures. Several hours after admission to the emergency department of the authors' institution, the @entity1 underwent closed reduction and internal fixation with intramedullary nails for the bilateral femoral diaphyseal fractures. Treatment with @entity4381 was immediately discontinued. In recent years, @entity3330 in @entity1 undergoing long-term @entity5520 treatment have been reported. It is believed that the prolonged treatment causes long-term suppression of bone remodeling and accumulation of microdamage. It is important to observe @entity1 who are undergoing @entity5520 treatment carefully. In this case study, the authors report the @entity1 's unique medical history. [Orthopedics. 2015; 38(11):e1051-e1054.].
