Dietary fiber and progression of XXXX : the Los Angeles @entity731 Study.

@entity1 @entity299 @entity731 @entity121 @entity65 @entity165
BACKGROUND: Several epidemiologic studies found weak protective relations between dietary fiber intake and the risk of @entity65 events. However, few of the studies addressed possible mechanisms of the effect. OBJECTIVE: In the present study, we estimated relations between the progression of @entity731 and the intake of selective dietary fiber fractions. Mediation of the relations by serum lipids was also investigated. DESIGN: @entity1 who were free of @entity299 and aged 40-60 y were recruited into the cohort (n = 573; 47% @entity1 ). The @entity121 ( @entity121 ) of the common carotid arteries was measured ultrasonographically at the baseline examination and at 2 follow-up examinations (n = 500), dietary intakes were assessed with six 24-h recalls (3 at baseline and 3 at the first follow-up examination), and blood samples were analyzed at baseline and at both follow-up examinations. RESULTS: A significant inverse association was observed between @entity121 progression and the intakes of viscous fiber (P = 0.05) and pectin (P = 0.01). Correction for measurement error increased the magnitude of these estimated effects. The ratio of total to HDL @entity165 was inversely related to the intakes of total fiber (P = 0.01), viscous fiber (P = 0.05), and pectin (P = 0.01). The magnitude of the association between @entity121 progression and the intakes of viscous fiber and pectin was attenuated by adjustment for serum lipids. CONCLUSIONS: The intake of viscous fiber, especially pectin, appears to protect against @entity121 progression. Serum lipids may act as a mediator between dietary fiber intake and @entity121 progression.
