PKQuest: volatile solutes - application to XXXX , @entity3810 , @entity1508 , @entity11961 and @entity8336 pharmacokinetics.

@entity1 @entity11961 @entity1508 @entity8336 @entity3810 @entity4488
BACKGROUND: The application of physiologically based pharmacokinetic models (PBPK) to @entity1 studies has been limited by the lack of the detailed organ information that is required for this analysis. PKQuest is a new generic PBPK that is designed to avoid this problem by using a set of "standard @entity1 " default parameters that are applicable to most solutes. RESULTS: PKQuest is used to model the @entity1 pharmacokinetics of the volatile solutes. A "standard @entity1 " value for the lipid content of the blood and each organ (klip) was chosen. This set of klip and the oil/water partition coefficient then specifies the organ/blood partition for each organ. Using this approach, the pharmacokinetics of inert volatile solute is completely specified by just 2 parameters: the water/air and oil/water partition coefficients. The model predictions of PKQuest were in good agreement with the experimental data for the inert solutes @entity4488 and @entity3810 and the metabolized solutes @entity1508 and @entity8336 . METHODS: The experimental data that was modeled was taken from previous publications. CONCLUSIONS: This approach greatly increases the predictive power of the PBPK. For inert volatile solutes the pharmacokinetics are determined just from the water/air and oil/water partition coefficient. @entity11961 cannot be modeled by this PBPK because the arterial and end tidal partial pressures are not equal (as assumed in the PBPK). This inequality results from the "washin-washout" artifact in the large airways that is established for solutes with large water/air partition coefficients.PKQuest and the worked examples are available on the web www.pkquest.com.
