Neural stem cells. Biological features and therapeutic potential in XXXX .

@entity3034 @entity19 @entity191 @entity179 @entity2955 @entity528
AIM: Neural stem cells (NSC) are clonogenic cells, capable of self-renewal and multilineage differentiation, since, under the appropriated experimental conditions, they proliferate indefinitely as undifferentiated neurospheres or differentiate in neurons, astrocytes and oligodendrocytes. @entity191 is a @entity179 characterized by the progressive @entity528 . METHODS: Here we investigated the suitability of recently identified and characterized neuronal progenitor cells at eliciting functional recovery in unilateral 6HODA-lesioned @entity19 . We describe herein that intrastriatal engraftment of stem cell-derived neurons isolated from the olfactory bulb to give @entity528 results in long lasting functional recovery in 6OHDA-injured @entity19 . RESULTS: Unilateral injection of @entity2955 resulted in a progressive @entity179 of the nigro-striatal pathway. Likewise, the systemic administration of @entity3034 in these @entity19 elicited a marked contralateral turning which was evident 1 week post, increased during the following week and than stabilize throughout the time of the experiment. Conversely, the intrastriatal implantation of partially differentiated stem cells at 14 days postlesion, resulted in a profound decrease in @entity3034 -induced circling behavior; interestingly, the effect was evident 1 week after the engraftment and was retained during the following 9 weeks. Detailed biochemical and immunohistochemical evaluation is currently under investigation in our laboratory. Conclusion. Our observation opens new perspectives for the treatment of @entity179 in @entity191 .
