Selective noradrenergic denervation of the heart following intravenous injections of @entity5713 or XXXX .

@entity1891 @entity35 @entity1063 @entity528 @entity5713
1. The progressive effects of a single injection (3mg/kg i.v.) of either @entity5713 or @entity1891 on the innervation of the @entity35 atria have been examined. 2. Functional studies were performed by stimulating electrically the noradrenergic or cholinergic nerve fibres within isolated left atria from treated and control @entity35 . In addition, the effects of the drugs on the ultrastructure of both types of nerve fibre were examined. The noradrenergic innervation was further examined by fluorescence histochemistry and measurement of the @entity1063 content of the atria. 3. On the basis of these studies it appeared that both drugs caused @entity528 ; cholinergic nerves seemed to be unaffected. Marked effects were seen 48 h after @entity5713 treatment or 30 h after @entity1891 treatment. 4. Evidence is presented and discussed as to whether or not this action of the vinca alkaloids can be ascribed to their well-established effects on microtubules and intra-axonal transport processes.
