Vagal control of glucagon release in XXXX .

@entity1 @entity15669 @entity3897 @entity369 @entity413
A significant fall in fasting @entity15669 was produced by injection of @entity3897 . After @entity369 infusion @entity3897 reduced the normal rise of glucagon by 33% and @entity413 by 40%. Eleven @entity1 studied during insulin hypoglycaemia after a selective vagotomy showed a peak rise in plasma-glucagon of 173 pg. per ml., which was not significantly different from the glucagon rise in ten preoperative controls (168 pg. per ml.). The glucagon response to insulin hypoglycaemia (81 pg. per ml.) in a matched group of ten @entity1 with truncal vagotomy was significantly less than after selective vagotomy. This evidence of parasympathetic control of the alpha cell accords with morphological and laboratory-animal findings. Maintenance of normal glucagon release after selective vagotomy favours the use of this operation rather than the cruder truncal vagotomy.
