Experiences with nonfunctioning XXXX of the pancreas.

@entity5 @entity1 @entity490
AIM: We present our experiences in the treatment of nonfunctioning @entity5 of the pancreas to define the natural history and to suggest proper management. METHOD: From August 1993 to June 2005, the medical records of 19 @entity1 with the diagnosis of nonfunctioning neuroendocrine (islet cell) @entity5 of the pancreas were retrospectively reviewed with respect to @entity1 characteristics, characteristics of @entity5 , surgical procedures, and long-term outcomes in the Yonsei University Medical Center, Seoul, Korea. RESULTS: The median age of the @entity1 (10 males and 9 females) was 51 years. @entity490 and discomfort (58%) were the most frequent symptoms. @entity5 with a median size of 3.5 cm were noted in the head of the pancreas in 9 @entity1 and in the body or in the tail of the pancreas in 10 @entity1 . Thirteen @entity1 (68%) had @entity5 with malignant features. Twelve @entity1 (63%) underwent surgical resection, and curative resection was performed in 10 @entity1 (53%). Unresectable @entity5 (p=0.0055), distant metastases (p=0.0124), and macroinvasion to adjacent organs (p=0.024) had significantly adverse effects on the mean survival. Neither palliative surgery nor adjuvant chemoradiation therapy seemed to be effective. CONCLUSIONS: Early detection of nonfunctioning @entity5 of the pancreas is important, and curative resection should be attempted for a good prognosis.
