Second trimester angiotensing-converting enzyme and uterine artery Doppler as XXXX in a high-risk population.

@entity1 @entity1468 @entity1289
OBJECTIVE: To investigate whether serum angiotensing-converting enzyme ( @entity1289 ) and uterine artery Doppler (UAD) are useful markers as @entity1468 ( @entity1468 ) in a high-risk population. METHODS: @entity1 at risk of @entity1468 (n   =   68) were subclassified as having @entity1468 (n   =   8) or no @entity1468 (n   =   60). Blood samples were obtained between 19 and 22 weeks of gestation. Doppler ultrasound of the uterine arteries was done at the time of blood sampling. Maternal serum @entity1289 was determined through spectrophotometry assay (A15 Biosystem, ATOM, Barcelona, Spain). RESULTS: Comparing the group who presented @entity1468 with the one who was not developed it, we found significant differences for @entity1289 (54.2        21.2, 38.1        12.3 U/L; p   =   0.003); the pulsatility index (PI) (1.2        0, 3.1        0.3; p   =   0.032) and resistance index (RI) (0.7        0.1, 0.5        0.1; p   =   0.004). The AUC for @entity1289 was 0.724, so we selected the cutoff of 36.5   U/L (sensitivity: 62.5% and specificity: 86.7%). The AUC for PI was 0.652 choosing a cutoff of 1.4 (sensitivity: 57.1% and specificity: 93.1%). The AUC for RI was 0.712 and the cutoff of 0.7 (sensitivity of 71.4% and specificity: 89.6%). The combination that allowed us to increase the diagnostic performance was the @entity1289 +RI with Doppler study, increasing the AUC to 0.872. CONCLUSIONS: @entity1289 , PI and RI as parameters of Doppler study were useful predictors of @entity1468 in the second trimester of gestation. The best combination to increase the diagnostic performance was @entity1289 with the RI.
