Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during XXXX metamorphosis.

@entity27570 @entity1238 @entity70858 @entity70856 @entity70859 @entity70855 @entity70857 @entity70854
The biological effects of thyroid hormone (T3) are mediated by the thyroid hormone receptor (TR). Amphibian metamorphosis is one of the most dramatic processes that are dependent on T3. T3 regulates a series of orchestrated developmental changes, which ultimately result in the conversion of an aquatic herbivorous tadpole to a terrestrial carnivorous frog. T3 is presumed to bind to TRs, which in turn recruit coactivators, leading to gene activation. The best-studied coactivators belong to the p160 or SRC family. Members of this family include @entity27570 /NCoA-1, @entity70854 / @entity70854 / @entity70855 , and @entity70856 /pCIP/ @entity70856 / @entity70856 / @entity70857 / @entity70858 . These SRCs interact directly with liganded TR and function as adapter molecules to recruit other coactivators such as @entity70859 / @entity70859 . Here, we studied the expression patterns of these coactivators during various stages of development. Amongst the coactivators cloned in @entity1238 , @entity70856 was found to be dramatically upregulated during natural and T3-induced metamorphosis, and @entity70854 and @entity70859 are expressed throughout postembryonic development with little change in their expression levels. These results support the view that these coactivators participate in gene regulation by TR during metamorphosis.
