Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: XXXX expression is an independent predictor of recurrence.

@entity1 @entity32 @entity404 @entity986 @entity5 @entity10807 @entity469 @entity2225 @entity405 @entity982 @entity403 @entity3 @entity13221 @entity17539
UNASSIGNED: @entity17539 ( @entity17539 ) are relatively rare, but devastating @entity5 , more frequent among @entity1 of underprivileged socioeconomic status. There is mounting evidence that immune cells may trigger various mechanisms that enhance @entity5 growth and @entity3 , but no data on the peritumoral @entity32 is available for @entity17539 . The objectives of the present study are to evaluate the immunohistomorphology of @entity5 in @entity17539 , and to correlate it with clinicopathological parameters, which could contribute to the prognostic evaluation. One hundred and twenty-two @entity1 with the diagnosis of usual-type squamous cell @entity17539 were included. @entity982 -embedded tissue was submitted to immunohistochemical evaluation of @entity986 protein, CD3, @entity404 , @entity405 , @entity2225 , @entity469 , @entity13221 , @entity10807 , and @entity403 . The Fisher's exact test was employed for comparison between histological variables and parameters, and the Kaplan-Meier method for the analysis of survival. Improved 5-year overall survival was significantly associated to age  <=60  years, stage I   +   II, @entity5 size T1   +   T2, lymph node status N0, and absent perineural invasion. In a multivariate analysis age >= 60  years, presence of lymph node @entity3 , urethral invasion, and high histologic grade retained a significantly more unfavorable outcome. Improved 5-year failure free survival was associated to stage of the disease I   +   II, lymph node status N0, absence of perineural, vascular, and urethral invasion, and @entity403 expression. In a multivariate analysis, presence of lymph node @entity3 , perineural and vascular invasion, and of @entity403 -positive lymphocytes together with low inflammatory infiltrate retained a significantly more unfavorable outcome. These results support the prognostic value of determining the levels of @entity403 -positive lymphocytes by immunohistochemistry in @entity17539 , as this parameter adds value to the traditional clinicopathological features.
