Identification of polymorphisms associated with production traits on XXXX ( @entity1573 ) chromosome 4.

@entity59365 @entity71272 @entity71270 @entity71271 @entity1573 @entity1017
UNASSIGNED: Genetic selection for production traits has resulted in a rapid improvement in animal performance and development. Previous studies have mapped quantitative trait loci for body weight at 35 and 41 days, and drum and thigh yield, onto @entity1573 chromosome 4. We investigated this region for single nucleotide polymorphisms and their associations with important economic traits. Three positional candidate genes were studied: @entity71270 (Kr  eppel-like factor 3), @entity71271 ( @entity71271 ), and @entity59365 ( @entity71272 ). Fragment sequencing of these genes was conducted in 11 F1 animals, and one polymorphism in each gene was selected and genotyped in an F2 population (N = 276) and a paternal broiler line TT (N = 840). Associations were identified with growth, carcass, and fat traits in the F2 and the paternal line (P < 0.05). Using single markers in both the F2 and the TT line, @entity71270 was associated with @entity1017 (P < 0.05), PPPARGC1A was associated with liver and wing-parts weights and yields (P < 0.05), and @entity71271 was associated with back yield (P < 0.05) and fat traits (P < 0.05). Using multiple markers, @entity71270 lost its significance in both populations, and @entity71271 was associated with feed conversion only in the TT population (P < 0.05). The QTLs mapped in the F2 population could be partly explained by @entity59365 and @entity71271 , which were associated with body weight at 35 and 41 days, respectively, and with drum and thigh yield in the same population. The results of this study indicate the importance of these genes for production traits.
