[Sex hormones and the hypophyseo-gonadal axis in females with XXXX in postmenopause].

@entity1 @entity251 @entity82 @entity53 @entity134 @entity1815 @entity1575 @entity2671
The hormonal status of @entity1 with @entity1575 has been investigated in numerous studies. Little, however, is known about changes of sexual hormones in @entity1 afflicted by this disorder. In a study of 31 postmenopausal @entity1 (mean age 63 +/- 8 years) suffering from @entity82 of various etiology (alcoholic, n = 8; posthepatitic B, n = 1; PBC, n = 5; cryptogenetic, n = 17) the blood levels of @entity53 (E2), @entity1815 (E1), @entity2671 (A), @entity251 (T) and basal and stimulated values of gonadotropins are reported and compared with the data obtained in an age-matched control group (n = 9). In @entity82 a significant increase of the median E2 (28 vs 12 pg/ml, P less than 0.01) was found, whereas the changes of the blood levels of E1 (88 vs 76 pg/ml), A (63 vs 111 ng/dl), and T (0.30 vs 0.15 ng/ml) did not attain statistical significance in comparison to controls. Within the study group, however, a significant positive correlation with the degree of decompensation of @entity82 (Childscore A-C) was observed for the @entity134 hormones measured. Thus, in subgroup C the hormone levels are higher than physiologically expected for postmenopausal @entity1 . On the other hand the median FSH (32 vs 48 mU/ml, P less than 0.05) is significantly lower in @entity82 compared to controls with a trend to decreased values of LH. Very low levels of LH and FSH are found in decompensated @entity82 . The decrease of LH and FSH can partly be explained by the rise of peripheral hormones (i.e. E2, E1, and in some cases T and A).(ABSTRACT TRUNCATED AT 250 WORDS)
