Effects of @entity7776 and @entity2847 on XXXX and sensorimotor gating: parametric studies and cross-species comparisons.

@entity1 @entity2847 @entity1024 @entity7371 @entity935 @entity143 @entity7776 @entity35 @entity427
BACKGROUND: We recently reported that prepulse inhibition (PPI) in @entity1 was increased by the @entity935 (DA) agonist/ @entity1024 ( @entity143 ) antagonist @entity7776 (200 mg), but was not significantly altered by the DA agonist @entity2847 (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in @entity35 under specific stimulus conditions, including short prepulse intervals (<30 ms). We characterized the effects of @entity7776 and @entity2847 on PPI across species, assessing: (1) dose-response effects on PPI in @entity35 over 10- to 120-ms prepulse intervals; (2) drug effects on PPI in @entity1 , using this same range of prepulse intervals; and (3) drug effects on measures related to @entity7371 , including PPI of perceived stimulus intensity (PPIPSI), and @entity427 . METHODS: Drug effects on PPI were assessed in male @entity35 ( n=90) and @entity1 ( n=49); @entity427 and PPIPSI were also studied in @entity1 . RESULTS: @entity7776 and @entity2847 exhibited dose- and stimulus-dependent effects on PPI in @entity35 , increasing PPI with short (10-20 ms) prepulse intervals, and decreasing PPI with long (60-120 ms) prepulse intervals. In @entity1 , @entity7776 increased PPI with both short (20 ms) and long (120 ms) prepulse intervals. @entity2847 had no significant effect on PPI in @entity1 , but tended to increase PPI at short (20 ms) intervals. @entity7776 eliminated PPIPSI. CONCLUSIONS: @entity7776 modifies prepulse effects on @entity427 in @entity35 and @entity1 , and disrupts prepulse effects on perceived stimulus intensity in @entity1 ; @entity2847 has clear effects on PPI in @entity35 , but not in @entity1 . The divergent effects of @entity7776 on sensorimotor and sensory effects of prepulses may reflect a divergence of brain circuitry regulating these processes.
