@entity1937 -induced preconditioning has cross-talk with A1 and A2B XXXX receptors in ischemic-reperfused @entity35 heart.

@entity859 @entity63 @entity301 @entity39 @entity1510 @entity1188 @entity35 @entity1937
UNASSIGNED: The purpose of this study was to determine whether there is a cross-talk between opioid receptors (OPRs) and @entity859 receptors (ADRs) in @entity1937 preconditioning (R-Pre) and, if so, to investigate the types of ADRs involved in the cross-talk. Isolated @entity35 hearts received 30 min of regional @entity63 followed by 2 hr of reperfusion. OPR and ADR antagonists were perfused from 10 min before R-Pre until the end of R-Pre. The heart rate, left ventricular developed pressure (LVDP),velocity of contraction (+dP/dtmax), and @entity301 ( @entity301 ) were recorded. The area at risk and area of @entity39 were measured. After reperfusion, the LVDP, +dP/dtmax,and @entity301 showed a significant increase in the R-Pre group compared with the control group (no intervention before or after regional @entity63 ). These increases in the R-Pre group were blocked by @entity1510 , a nonspecific ADR antagonist, an A1 ADR antagonist, and an A2B ADR antagonist. The @entity1188 size was reduced significantly in the R-Pre group compared with the control group. The @entity1188 -reducing effect in the R-Pre group was blocked by @entity1510 , the nonspecific ADR antagonist, the A1 ADR antagonist, and the A2B ADR antagonist. The results of this study demonstrate that there is cross-talk between ADRs and OPRs in R-Pre and that A1 ADR and A2B ADR appear to be involved in the cross-talk.
