Development of gamma (gamma)- XXXX as a @entity14 chemopreventive agent.

@entity270 @entity5 @entity2076 @entity1881 @entity4793 @entity14 @entity271 @entity694
Nutritional factors play an important role in the prevention and promotion of @entity14 . @entity270 is a generic term that describes a group of lipid-soluble chain-breaking antioxidants that includes @entity4793 and @entity271 . @entity270 occurs in nature as eight structurally related forms that include four @entity4793 and four @entity271 . @entity270 is a potent membrane-soluble antioxidant. Antioxidants like @entity270 ( @entity4793 ) may prevent @entity694 through several different cellular and molecular mechanisms. @entity270 in the American diet is primarily available in plant-oil rich foods such as vegetable oils, seeds and nuts and these foods vary widely in their content of @entity1881 and @entity2076 . @entity270 may help prevent @entity694 by decreasing the formation of mutagens arising from the oxidation of fecal lipids, by decreasing oxidative stress in the epithelial cells of the colon and by molecular mechanisms that influence cell death, cell cycle and transcriptional events. Most epidemiological, experimental and clinical studies have evaluated the alpha-isoform and not the gamma-isoform of @entity270 . Recent epidemiological, experimental and mechanistic evidence suggests that @entity2076 may be a more potent @entity5 chemopreventive agent than @entity1881 . The differences in chemical reactivity, metabolism and biological activity may contribute to these differences in the effects of @entity2076 when compared with @entity1881 . The rationale supporting the development of @entity2076 as a @entity14 preventive agent is reviewed here.
