@entity3974 Does Not Attenuate Hemodynamic Changes in XXXX Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia: A Double-Blind, Placebo-Controlled, Randomized Trial.

@entity1 @entity3974 @entity390 @entity510 @entity391 @entity111 @entity2647 @entity750 @entity551
INTRODUCTION: @entity551 is the most common complication after @entity510 for cesarean delivery. Several therapeutic and preventive measures are used to attenuate this side effect. @entity750 receptor-blocking drugs have been suggested as one such approach. We sought to determine whether prophylactically administered intravenous @entity3974 could attenuate @entity551 in @entity1 undergoing elective cesarean delivery performed under @entity510 . METHODS: Eighty-six @entity1 undergoing elective cesarean delivery were recruited and randomly allocated to receive either 8 mg intravenous @entity3974 (group O; n = 44) or placebo (group P; n = 42) in a prospective double-blind design. Systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP), and heart rate (HR) were measured at baseline and at 3-minute intervals from the time of initiation of @entity510 until delivery. @entity3974 effect on hemodynamics (SBP, @entity551 ) was quantified and analyzed using a linear mixed effect model. RESULTS: We did not find differences in SBP (P = 0.78), MAP (P = 0.89), DBP (P = 0.82), or HR (P = 0.18) between the 2 groups during the study period. @entity2647 requirements to treat @entity551 were 350  g (175-700  g) in group O and 450  g (300-700  g) in group P (P = 0.30). The incidence of @entity111 was 63% (n = 28 of 44) in group O and 56% (n = 23 of 42) in group P (difference, 0.08 [95% confidence interval, -0.23 to 0.41], P = 0.59). No difference in the incidence of @entity390 and @entity391 or sensory level was found. CONCLUSIONS: @entity3974 premedication does not attenuate hemodynamic changes after @entity510 nor does it reduce the amount of vasopressor use, @entity111 , or @entity390 and @entity391 .
