Inverse relationship between renal and urinary @entity7199 during chromate-induced @entity810 in @entity35 : urinary XXXX excretion as a possible recovery index.

@entity2011 @entity18525 @entity39 @entity75 @entity1372 @entity810 @entity972 @entity35 @entity7199
@entity810 ( @entity810 ) was induced in @entity35 following a single injection of @entity18525 . A transient @entity2011 and a 10-fold decrease in glomerular filtration rate was immediately observed after @entity18525 administration. Urinary @entity1372 and @entity972 excretion were reduced within 24 h and remained decreased for 8 to 10 days. Progressive recovery of normal renal functions, mainly electrolyte excretion and filtration rate was observed 12 days after @entity18525 administration. Urinary @entity7199 excretion (UKE) was decreased only 48 h after @entity18525 administration. However the proportion of the active and inactive form excreted was unchanged. UKE remained also at a reduced level for 8 to 10 days and returned progressively to base-line level. The @entity7199 content in the tissue was significantly increased immediately after @entity18525 administration and recovered normal values 12 days later. The increase of @entity7199 in the tissue is more likely unspecific due to impaired protein transport than a specific stimulation of renal @entity7199 biosynthesis. The decreased UKE may indicate a distal tubular reversible dysfunction in this @entity810 model. These reductions in electrolyte excretion, glomerular filtration and UKE were associated with selective morphological lesions. Whereas the glomeruli were intact, important damages affected proximal tubule cells which appeared @entity39 and showed presence of vacuoles, liquefaction of cytoplasmic material and lost of microvilli. @entity75 were however observed in distal tubules, particularly large vacuoles were present at the apical poles of the tubule cells, the sites of @entity7199 secretion. These distal damages may be involved in the increase of tissue concentration and in the decrease of UKE.(ABSTRACT TRUNCATED AT 250 WORDS)
