Effect of ACE inhibitors and angiotensin II receptor antagonists in a @entity19 model of XXXX .

@entity101 @entity39 @entity5 @entity19 @entity7056 @entity3371 @entity14 @entity14207
BACKGROUND AND AIMS: Angiotensin converting enzyme inhibitors (ACE-I) and angiotensin II type I receptor ( @entity14207 ) antagonists are commonly used as a treatment for @entity101 . Recent experimental and population studies have suggested that these agents may exert an inhibitory effect on malignancy, possibly through anti-angiogenic pathways. The aim of this study was to investigate the effect of an ACE-I ( @entity3371 ) and an @entity14207 antagonist ( @entity7056 ) in @entity14 . METHODS: The effect of @entity3371 and @entity7056 on @entity5 growth was investigated in a @entity19 model using quantitative stereological and histological analysis. @entity5 microcirculation was assessed by microvascular resin casting. A survival study was also carried out. RESULTS: Both @entity3371 and @entity7056 markedly decreased @entity5 growth when compared to control (P = 0.003 and P = 0.004, respectively). However, there was no significant difference in survival or @entity5 @entity39 for either of the drugs. @entity5 microvasculature exhibited a reduction in central microvascular density, with constriction and tapering of vessels. CONCLUSION: @entity3371 and @entity7056 caused a marked reduction in volume of @entity14 and caused changes in @entity5 microvasculature. However, there was no difference in percentage @entity5 @entity39 or improvements in survival. Further investigation is needed to identify the mode of action of these agents.
