XXXX protects against lipopolysaccharide-induced @entity647 in @entity35 .

@entity5694 @entity39 @entity5 @entity568 @entity11545 @entity358 @entity22520 @entity35 @entity1589 @entity19447 @entity647
Lipopolysaccharide (LPS)-induced @entity5694 triggers the secretion of proinflammatory cytokines and can cause @entity647 ( @entity647 ). The @entity22520 ( @entity22520 ) protein plays an important role as a late mediator of sepsis and @entity647 . @entity11545 ( @entity19447 ) is a central acetylcholinesterase inhibitor that inhibits the expression of @entity22520 . This study evaluated the effects of @entity19447 by measuring levels of inflammatory mediators and observing histopathological features associated with LPS-induced @entity647 . Sixty 8-10 week old male @entity35 (200-240 g) were randomized into three groups as follows: control group, LPS group (7.5 mg/kg LPS), and LPS+ @entity19447 group (5 mg/kg @entity19447 before LPS administration). Histopathological examination of lung specimens obtained 12 h after LPS administration was performed to analyze changes in wet-to-dry (W/D) weight ratio, @entity1589 ( @entity1589 ) activity, and @entity22520 expression level. Additionally, plasma concentrations of @entity5 @entity39 factor-a, @entity568 , and @entity22520 were measured using an enzyme-linked immunosorbent assay at 0 (baseline), 3, 6, 9, and 12 h after LPS administration. Mortality in the three groups was recorded at 72 h. LPS-induced @entity647 was characterized by distortion of @entity358 and elevation of @entity1589 activity, W/D weight ratio, and levels of pro-inflammatory cytokines, including @entity5 @entity39 factor-a, @entity568 , and @entity22520 . Pretreatment with @entity19447 significantly reduced the LPS-induced lung pathological changes, W/D weight ratio, levels of pro-inflammatory cytokines and @entity1589 activity (ANOVA). Moreover, @entity19447 treatment significantly decreased the mortality rate (ANOVA). In conclusion, we demonstrated that @entity19447 exerted a protective effect on LPS-induced @entity647 in @entity35 .
