Impact of Left Ventricular Hypertrophy on Troponin Release During XXXX : New Insights From a Comprehensive Translational Study.

@entity1 @entity1707 @entity1184 @entity908 @entity6949 @entity1188 @entity583 @entity1002
BACKGROUND: Biomarkers are frequently used to estimate @entity1188 ( @entity1188 ) as an endpoint in experimental and clinical studies. Here, we prospectively studied the impact of left ventricular (LV) @entity1184 (LVH) on biomarker release in clinical and experimental @entity583 ( @entity583 ). METHODS AND RESULTS: @entity583 ( @entity583 ) @entity1 (n=140) were monitored for total @entity908 kinase (CK) and @entity6949 ( @entity6949 ) over 72 hours postinfarction and were examined by cardiac magnetic resonance (CMR) at 1 week and 6 months postinfarction. @entity583 was generated in @entity1707 with induced LVH (n=10) and in sham-operated @entity1707 (n=8), and serial total CK and @entity6949 measurements were performed and CMR scans conducted at 7 days postinfarction. Regression analysis was used to study the influence of LVH on total CK and @entity6949 release and @entity1188 estimated by CMR (gold standard). Receiver operating characteristic (ROC) curve analysis was performed to study the discriminatory capacity of the area under the curve (AUC) of @entity6949 and total CK in predicting @entity1002 . Cardiomyocyte @entity6949 expression was quantified in myocardial sections from LVH and sham-operated @entity1707 . In both the clinical and experimental studies, LVH was associated with significantly higher peak and AUC of @entity6949 , but not with differences in total CK. ROC curves showed that the discriminatory capacity of AUC of @entity6949 to predict @entity1002 was significantly worse for @entity1 with LVH. LVH did not affect the capacity of total CK to estimate @entity1188 or @entity1002 . Immunofluorescence analysis revealed significantly higher @entity6949 content in @entity1184 . CONCLUSIONS: Peak and AUC of @entity6949 both significantly overestimate @entity1188 in the presence of LVH, owing to the higher troponin content per cardiomyocyte. In the setting of LVH, @entity6949 release during @entity583 poorly predicts postinfarction @entity1002 . LV mass should be taken into consideration when @entity1188 or LV function are estimated by troponin release.
