Polymorphism of the @entity2162 in XXXX in Chinese subjects.

@entity1 @entity2162 @entity535 @entity7647 @entity1030
STUDY OBJECTIVES: To assess the frequencies of three polymorphisms at @entity535 positions 16, 27, and 164 of the @entity2162 ( @entity2162 ) gene and their effects on @entity1030 @entity1 . DESIGN: Prospective, case-control study @entity1 : Sixty-five @entity1 with @entity1030 and 41 healthy subjects were included. MEASUREMENTS: Polymorphisms of the @entity2162 coding block were delineated using an allele-specific polymerase chain reaction (PCR) approach. The allele-specific PCR technique was verified by direct dideoxy sequencing of PCR products. Pulmonary function tests were performed in all @entity1 . RESULTS: The Arg16 @entity2162 polymorphism was less prevalent in @entity1030 @entity1 than in healthy populations (p = 0.01). A significant correlation (p < 0.018) between the @entity7647 27 @entity2162 polymorphism and FEV(1) percent predicted value was found. @entity1 with the Gln27 polymorphism had a higher percentage of low FEV(1) percent predicted than did @entity1 with the GlnGlu and GluGlu variants. CONCLUSIONS: The polymorphism of Gly16 may increase the @entity1 's susceptibility to the development of @entity1030 . The Gln27 @entity2162 polymorphism may be associated with the severity of @entity1030 in a Chinese population.
