Early probiotics to prevent XXXX : A systematic review.

@entity1 @entity28 @entity2299 @entity1905 @entity6983 @entity15 @entity209 @entity4854
AIM: To conduct a systematic review of studies on early probiotic supplementation to prevent @entity209 ( @entity209 ). METHODS: Using the Cochrane systematic review strategy we searched PubMed, EMBASE, CENTRAL, CINAHL, and the conference proceedings of the Pediatric American Society meetings and trial registries in December 2014. Randomised controlled trials (RCTs) and non RCTs of probiotic supplementation to the mother and/or @entity1 for a minimum duration of 4 wk were selected. Of these, studies that reported on @entity209 or its components ( @entity28 , raised blood pressure, @entity4854 , @entity2299 ) in @entity1 between 2-19 years were to be eligible for inclusion in the review. Risk of bias (ROB) in selected RCTs and quality assessment of non-RCT studies were to be assessed by the Cochrane ROB assessment table and New Castle Ottawa scale. RESULTS: There were no studies on early probiotic administration for prevention of @entity15 ( @entity15 ). Follow up studies of two placebo controlled RCTs (n = 233) reported on the effects of early probiotics on one or more components of @entity209 in @entity1 aged 2-19 years. Meta-analysis of those two studies could not be performed due to differences in the @entity1 population, type of outcomes studied and the timing of their assessment. Assessment of childhood metabolic outcomes was not the primary objective of these studies. The first study that assessed the effects of prenatal and postnatal supplementation of @entity1905 on body mass index till 10 years, did not report a significant benefit. In the second study, @entity6983 19 was supplemented to healthy term @entity1 from 4-13 mo. No significant effect on body mass index, body composition or metabolic markers was detected. CONCLUSION: Current evidence on early probiotic administration to prevent @entity15 is inadequate. Gaps in knowledge need to be addressed before large RCTs can be planned.
