Chronic maintenance of presynaptic terminals in gliotic hippocampus following XXXX .

@entity1400 @entity2806 @entity63 @entity1399 @entity5219 @entity4176 @entity528
Following brief @entity2806 , neurons are selectively damaged and die, whereas glial cells and blood vessels survive. This phenomenon of selective vulnerability is well illustrated in the hippocampal @entity1399 region. Five min of forebrain @entity63 in the Mongolian gerbil produced selective @entity528 in the hippocampal @entity1399 sector. After destruction and loss of @entity1399 neurons, a remarkable glial reaction ( @entity5219 ) was seen. The thickness of the @entity1399 subfield remained unchanged until 1 month after @entity63 and then gradually shrank over several months. Ultrastructural observation of this region revealed persistent maintenance of presynaptic structures. Numerous presynaptic terminals containing synaptic vesicles were scattered throughout the gliotic scar tissue. These presynaptic terminals were apposed to degenerative structures which seemed most likely to be remnants of dendrites. In another group of animals, at one month following ischemic damage in the @entity1399 sector, the @entity1400 neurons were destroyed by @entity4176 injection. In these animals, numerous degenerating presynaptic boutons were seen in the @entity1399 sector when fixed 4 days following @entity4176 injection. These results indicate that even in gliotic tissue, presynaptic terminals can survive and maintain their structural characteristics although neuronal cell bodies are almost absent.
