Lack of expression of galectin-3 is associated with a poor outcome in node-negative @entity1 with XXXX .

@entity1 @entity5 @entity957 @entity1735 @entity204
PURPOSE: Galectin-3 is a pleiotropic @entity1735 -binding protein participating in a variety of normal and pathologic processes, including @entity5 progression. This study was aimed at evaluating the prognostic value of galectin-3 expression in node-negative @entity957 (SCC). @entity1 AND METHODS: Galectin-3 expression was analyzed by immunohistochemistry using M3/38 monoclonal antibody, in a single-institution series of 73 node-negative laryngeal SCC @entity1 (median follow-up, 52 months; range, 2 to 90 months). RESULTS: Forty-two (57.5%) of 73 @entity1 expressed galectin-3. Galectin-3 expression was positively associated with @entity5 keratinization and histologic grade. A significant correlation was found between galectin-3 @entity5 positivity and longer relapse-free and overall survival. In univariate analysis, high-grade (grade 3 or 4) @entity5 , nonkeratinizing @entity5 , and galectin-3-negative @entity5 showed a significantly increased risk of relapse and @entity204 . In multivariate analysis, only galectin-3 expression retained an independent prognostic significance for both relapse-free and overall survival. CONCLUSION: We conclude that the absence of galectin-3 expression is an independent negative prognostic marker in laryngeal SCC @entity1 . Thus, histochemical detection of galectin-3 in these @entity5 could be useful for the selection of node-negative @entity1 with potentially unfavorable outcomes, to establish adjuvant therapy protocols.
