Smoking Does Not Affect Occlusion Rates and Morbidity-Mortality after Pipeline Embolization for XXXX .

@entity1 @entity286 @entity439 @entity432 @entity438
BACKGROUND AND PURPOSE: Smoking is a major risk factor for @entity1 with @entity438 , yet the effects of smoking on outcomes of @entity439 with flow-diverter treatment remain unknown. We studied the impact of smoking on long-term angiographic and clinical outcomes after flow-diverter treatment of @entity438 . MATERIALS AND METHODS: We retrospectively reviewed data from @entity1 treated with the Pipeline Embolization Device and included in the International Retrospective Study of the Pipeline Embolization Device, the Pipeline for Uncoilable or Failed @entity439 Study, and the @entity439 Study of Pipeline in an Observational Registry. @entity1 were stratified according to smoking status into 3 groups: 1) never smoker, 2) current smoker, and 3) former smoker. We studied angiographic and clinical outcomes. Outcomes were compared by using   (2) and Student t tests. A multivariate analysis was performed to determine whether smoking was independently associated with poor outcomes. RESULTS: Six hundred sixteen @entity1 with 694 @entity439 were included. Current smokers had a smaller mean @entity439 size compared with the other 2 groups (P = .005) and lower rates of multiple Pipeline Embolization Device use (P = .015). On multivariate analysis, former smokers (OR, 1.08; 95% CI, 0.43-2.71; P = .57) and current smokers (OR, 0.70; 95% CI, 0.27-1.77; P = .38) had similar odds of long-term angiographic incomplete @entity432 compared with never smokers. Former smokers (OR, 1.27; 95% CI, 0.64-2.52; P = .25) and current smokers (OR, 0.74; 95% CI, 0.37-1.46; P = .22) had similar odds of major morbidity and neurologic mortality compared with never smokers. CONCLUSIONS: These results suggest that smoking is not associated with angiographic and clinical outcomes among @entity1 treated with the Pipeline Embolization Device. Nonetheless, @entity1 with @entity438 should continue to be counseled about the risks of @entity286 smoking.
