Sex-Related Prognostic Predictors for XXXX Undergoing Subthalamic Stimulation.

@entity1 @entity3034 @entity2003 @entity910 @entity191 @entity400
BACKGROUND: A few reports have addressed the sex-related efficacy of deep brain stimulation (DBS) in the subthalamic nucleus (STN) to treat advanced @entity191 ( @entity191 ). The present study evaluates the sex-related prognostic factors for STN-DBS outcomes. METHODS: Seventy-two consecutive @entity1 (48 @entity1 and 24 @entity1 ) were reviewed retrospectively. Changes in the Unified @entity191 Rating Scale scores were compared between @entity1 and @entity1 in the 6-month drug-off/DBS-on state relative to the preoperative drug-off baseline. A multivariate linear regression model was used to identify the preoperative factors predictive of motor improvements after surgery. RESULTS: Before surgery, the male and female @entity1 groups were comparable in clinical severity, except the @entity1 were associated with slightly inferior cognition (P < 0.05) and a relatively better response to @entity3034 (LD) (P < 0.05) than the @entity1 . Both sexes showed similar clinical improvements after STN-DBS therapy. In @entity1 , preoperative lower LD requirement and higher motor dysfunction, particularly @entity400 (adjusted R(2) = 0.613, P < 0.001), as well as greater improvement in @entity400 and @entity2003 after LD therapy (adjusted R(2) = 0.232, P = 0.001) were favorable predictors of surgical outcomes. @entity1 achieved a significant improvement if they performed well in activities of daily living even with higher baseline motor scores (adjusted R(2) = 0.620, P < 0.001), or exhibited improvements in @entity910 disability after preoperative LD therapy (adjusted R(2) = 0.305, P = 0.003). CONCLUSIONS: STN-DBS therapy is equally beneficial for both sexes. Sex-related differences exist with regard to favorable prognostic predictors for early surgical outcomes.
