Myocardial stretch induced by increased left ventricular diastolic pressure preconditions isolated perfused hearts of normotensive and spontaneously XXXX @entity35 .

@entity101 @entity63 @entity880 @entity741 @entity35
OBJECTIVE: The aim of our study was to determine whether myocardial stretch (non- @entity63 stress) could precondition isolated perfused hearts of both normotensive Wister-Kyoto (WKY) @entity35 and spontaneously @entity101 @entity35 (SHR). METHODS: The perfused hearts in Langendorff mode were subjected to 30 min of global no-flow @entity63 followed by 30 min of reperfusion. Left ventricular developed pressure (LVDP) and end-diastolic pressure (LVEDP) were measured. In the control group, LVEDP was set at 10 mmHg. In the stretch group, LVEDP was increased to 30 or 60 mmHg for 5 min before 30 min of @entity63 . In the @entity63 preconditioning group, the hearts were exposed to two cycles of a 5-min period of @entity63 before 30 min of @entity63 . Myocardial @entity880 contents were measured at the baseline and at the end of the 60 mmHg stretch. RESULTS: Hemodynamic parameters of LVDP and LVEDP at 30 min of reperfusion improved in the stretch group (LVEDP of 60 mmHg) and the @entity63 preconditioning group. Coronary flow did not decrease during the stretch. Recovery of the coronary flow during reperfusion was better in the stretch and @entity63 preconditioning groups. Postischemic contractile function was better in WKY @entity35 than in SHR. Myocardial @entity880 contents at the end of 60 mmHg stretch were negligible. CONCLUSIONS: Myocardial stretch induced by increasing LVEDP preconditioned isolated perfused hearts of both WKY @entity35 and SHR, via mechanisms not involving @entity741 during stretch.
