Water-soluble @entity4832 microspheres for temporary embolization: development and in vivo characteristics in a XXXX kidney model.

@entity432 @entity1707 @entity939 @entity4832
PURPOSE: To preliminarily examine whether solubility of water-soluble @entity4832 ( @entity939 ) microspheres in blood plasma changes in proportion to their degrees of saponification. The study also examined their feasibility as a temporary embolic agents in the @entity1707 renal artery. MATERIALS AND METHODS: Three types of @entity939 microspheres with the degrees of saponification of 97 mol% (S97), 98 mol% (S98), and 99 mol% (S99) were prepared. Seven kidneys in seven miniature @entity1707 were embolized and divided into three groups so there would be at least two kidneys for each type of @entity939 . One animal in each group was euthanized immediately after angiography at 3 hours after embolization and the other one at 7 days after. In addition, one animal embolized with S99 microspheres was euthanized at 21 days after embolization. RESULTS: With S97 microspheres, the vascular network had recovered to the preembolic state by 3 hours after embolization. With S98 microspheres, blood flow in the third-order branch had been restored in the same period. With S99 microspheres, the second- and lower order branches remained occluded until 21 days. Histopathologic specimens harvested at 3 hours revealed only a trace of @entity939 for S97 microspheres. With S98 microspheres, the vascular lumen was still found to be filled with @entity939 gel. With S99 microspheres, swollen microspheres densely filled the vascular lumen even on day 21. CONCLUSIONS: Dissolution process in vitro and the duration of @entity432 in vivo were possibly related to the degree of saponification of @entity939 . This result may support feasibility of @entity939 microspheres as a temporary embolic agent.
