Remote XXXX conditioning and renal function after contrast-enhanced CT scan: A randomized trial.

@entity1 @entity8 @entity63 @entity470 @entity1011
PURPOSE: Remote @entity63 conditioning has been shown to protect against @entity8 in animal and @entity1 studies of @entity63 -reperfusion. Recent evidence suggests that conditioning may also provide protection against @entity8 caused by contrast medium. The purpose of this study was to determine if conditioning protected against increases in serum @entity1011 (SCr) after contrast-enhanced computed tomography (CECT). METHODS: A randomised controlled trial (NCT 01741896) was performed with institutional review board approval and informed @entity1 consent. Adult in- @entity1 undergoing abdomino-pelvic CECT were allocated to conditioned or control groups. Conditioning consisted of four cycles of five minutes of cuff-induced arm @entity63 with three minutes of reperfusion applied ~40 minutes before CECT. The primary outcome was SCr change after CECT. RESULTS: Baseline characteristics were similar in both groups. For all @entity1 , conditioning reduced the risk ratio (RR) of increased SCr; RR 0.65 (95% confidence intervals 0.41 to 1.04). The protective effect was greater and the evidence for protection stronger when analysis was restricted to @entity1 with pre-scan reduced renal function ( @entity470 .
