Effect of XXXX on myocardial @entity419 SPECT using acipimox for the assessment of myocardial viability.

@entity8984 @entity1 @entity2175 @entity296 @entity419 @entity6 @entity1723 @entity1718 @entity413
During the noninvasive assessment of myocardial viability with @entity419 metabolic imaging, adequate regulation of metabolic conditions is needed to ensure optimal image quality. The aim of this study was to compare the feasibility and image quality of cardiac @entity8984 -FDG SPECT imaging using acipimox in @entity1 with @entity6 and @entity1 without @entity6 . METHODS: Seventy @entity1 with @entity296 underwent @entity419 SPECT using acipimox for the assessment of myocardial viability, followed by resting 2-dimensional echocardiography to identify dysfunctional myocardial tissue. The image quality was scored visually and quantitatively; the myocardium-to-background ratio was determined by region-of-interest analysis. The plasma concentrations of @entity413 and free @entity1718 were determined to evaluate the metabolic conditions before and during @entity419 imaging. RESULTS: Thirty-four @entity1 had @entity6 ; of these, 12 had @entity1723 and 22 had @entity2175 . The remaining 36 @entity1 had no @entity6 . During @entity419 SPECT, no severe side effects occurred. Acipimox significantly lowered plasma levels of free @entity1718 in both groups. Fifteen of 34 @entity1 with @entity6 had a plasma @entity413 level > 9 mmol/L, which was lowered successfully in all @entity1 with additional insulin. Visual evaluation of the @entity419 images showed good, moderate, and poor image quality in 27, 5, and 2 @entity1 , respectively, with @entity6 and in 32, 4, and 0 @entity1 , respectively, without @entity6 (P = not statistically significant). The myocardium-to-background ratio of @entity419 SPECT images was comparable in @entity1 with and without @entity6 (3.1 +/- 1.0 vs. 3.5 +/- 0.9, P = not statistically significant). The type of @entity6 had no influence on @entity8984 -FDG image quality. CONCLUSION: @entity419 SPECT metabolic imaging after acipimox is safe and practical for routine assessment of viability in @entity1 with @entity296 . Image quality is good, even in @entity1 with @entity6 , although additional insulin is sometimes needed.
