Characteristics of Alpha Band Frequency in Adolescents with XXXX : A Resting-State QEEG Study.

@entity1 @entity162 @entity308 @entity1555 @entity717
OBJECTIVE: The aim of this study was to compare the QEEG of adolescents affected by @entity162 with age and gender matched healthy controls, and to extract the characteristics of the alpha frequency band to better understand this disorder. METHODS: Twenty one adolescents affected by acute episodes of @entity162 ( @entity1555 II), both hypomanic and @entity308 , were selected via convenience sampling based on DSM IV criteria and @entity1 and adolescent psychiatrist diagnosis. Eleven @entity1 were going through a hypomanic episode and 10 @entity1 were going through a @entity308 episode. Of the @entity1 , 18 who were matched with the @entity1 group participated in this study as a normal group. Any major comorbidities and @entity717 were excluded through applying K-SADS-PL and Raven's IQ test for all the @entity1 and the healthy @entity1 . Electroencephalogram signals were obtained according to 10-20 international system by 21 electrodes from @entity1 in open and closed eyes in a resting state. We selected 40 seconds length segments from each recorded EEG signals that had minimal noise and artifacts. Power spectrum density (PSD) was estimated for each segment and extracted alpha band frequency. We used only referential (unipolar) montage for comparison. Eventually, data were analyzed by independent Mann-Whitney test and independent t test. RESULTS: We observed significant differences in the alpha frequency band in some brain regions. Alpha power increased in the fronto-central region and right parietal lobe in the @entity1 (P < 0.05). In the @entity1 with @entity1555 II, entropy of alpha oscillations was larger than the normal @entity1 in the central region and in the F3, F4 and P4 channels. Also, there were differences in the variance of alpha oscillations in these regions between the two groups (P < 0.05). In the occipital lobe, alpha wave had different skewness between the two groups (P < 0.05). CONCLUSION: Thalamus as a generator and modulator of at least a part of alpha oscillations may be involved in this disorder and hence this explains the major symptoms like distractibility and inattention in both hypomanic and @entity308 of @entity162 .
