Modulation of lipid metabolism in @entity11950 -treated XXXX fed on a high-calorie diet and exposed to short or long-term stress.

@entity3725 @entity844 @entity35 @entity13688 @entity11950 @entity48346 @entity70694 @entity209 @entity1718
Stress and high-calorie diets increase the risk of developing @entity209 . @entity11950 (GA) has been shown to improve dyslipidaemia in @entity35 fed on a high-calorie diet. This study aimed to examine the effects of GA on lipid metabolism in @entity35 exposed to short- or long-term stress and on a high-calorie diet. The parameters examined included serum lipid profiles, serum free @entity1718 and @entity844 profiles in tissues, and expression of @entity3725 ( @entity3725 ), @entity13688 ( @entity13688 ), elongases and desaturases. Within the 14- or 28-day exposure groups, neither stress nor GA affected the lipid profile and serum free @entity1718 . Stress did not affect @entity3725 expression in both the 14- and 28-day exposure groups. However, GA-treated @entity35 from the former group had increased @entity3725 expression only in the kidney while all other tissues from the latter group were unaffected. Stress increased @entity3725 -y expression in the heart of the 28-day exposure group but its expression was unaffected in all tissues of the 14-day exposure group. GA elevated @entity3725 -y expression in the kidney and the skeletal muscles. Neither stress nor GA affected @entity13688 expressions in all tissues from the 14-day exposure group but its expressions were elevated in the QF of the stressed @entity35 and heart of the GA-treated @entity35 of the 28-day exposure group. As for the elongases and desaturases in the liver, stress down-regulated @entity70694 in the long-term exposure group while up-regulated @entity48346 in the short-term exposure group while hepatic desaturases were unaffected by stress. Neither elongase nor desaturase expressions in the liver were affected by GA. This research is the first report of GA on lipid metabolism under stress and high-calorie diet conditions and the results gives evidence for the role of GA in ameliorating MetS via site-specific regulation of lipid metabolism gene expressions and modification of @entity1718 .
