Maternal-fetal effects of XXXX on serum osmolality in @entity1468 .

@entity1 @entity2399 @entity1468 @entity460 @entity972
OBJECTIVE: To determine the effects of @entity2399 therapy on maternal and fetal osmolality in @entity1468 . METHODS: A total of 34 pre-eclamptic @entity1 and 22 normal pregnant @entity1 participated in the study. Venous blood was drawn upon admission to the labor and delivery unit. Pre-eclamptic @entity1 received standard @entity2399 therapy and had a second sample of venous blood drawn 4 h following the beginning of therapy. Fetal umbilical vein blood was obtained immediately following delivery in both groups. Osmolality was measured using a vapor pressure osmometer. Electrolyte levels were measured with a NOVA 8 biomedical analyzer. Data were analyzed via Student's t test, linear regression and correlation with significance established at p < 0.05. RESULTS: We found no significant difference between the maternal osmolalities of the control and pre-eclamptic groups. Interestingly, fetal cord blood osmolality was significantly lower than maternal osmolality in the normal pregnant @entity1 . Sodium levels were also lower, while @entity972 and ionized @entity460 levels were higher in the fetal blood. In @entity1 with @entity1468 treated with @entity2399 , there was no difference between the osmolality of the maternal and fetal blood, while @entity972 and ionized @entity460 levels were still higher in the fetal blood. Finally, we found no correlation between maternal osmolality and blood pressure. CONCLUSIONS: High blood pressure in @entity1468 is not associated with altered osmolality. An absence of the normal decrease in fetal osmolality is observed in pre-eclamptic @entity1 treated with @entity2399 .
