Applying the Nottingham Prognostic Index to a Swedish @entity0 population. South East Swedish XXXX Study Group.

@entity5 @entity1 @entity0
The aim of this study was to assess the applicability of histopathological grading according to the protocol of Elston/Ellis and the Nottingham Prognostic Index (NPI) to a defined @entity0 population. The NPI is the sum of the individual scores concerning grade, @entity5 size, and lymph node status, each weighted according to regression coefficients of a Cox proportional hazard analysis and calculated for each individual @entity0 @entity1 . 630 consecutive @entity1 with invasive @entity0 diagnosed 1988-91 were retrospectively followed up and their @entity5 reviewed and graded. A Cox proportional hazard analysis was performed. Grade, lymph node status, and @entity5 size were statistically significant predictors of survival within the follow up period (median 7.2 years). Similar to NPI, a temporary index (Kalmar Prognostic Index, KPI) was derived and normalised to NPI for comparison (KPI(norm)). NPI and KPI(norm) gave similar prognostic power in spite of the differences of the @entity1 populations from which the 2 indices were derived. @entity1 with NPI 4 or less had 0.66% @entity0 specific mortality during the follow up time. 14% of the @entity1 with NPI 4.1-5 and 32% of those with an index sum 5.1-6 died from @entity0 during this time. Younger @entity1 tended to have higher grade @entity5 . We advocate the common use of grade and the NPI in order to increase the comparability of groups of @entity1 receiving different therapies.
