Longitudinal driving performance in early-stage @entity303 of the XXXX .

@entity303 @entity1 @entity7958 @entity195
OBJECTIVES: To longitudinally assess on-road driving performance in healthy older adults and those with early-stage @entity303 of the @entity195 (DAT). DESIGN: A prospective longitudinal study. SETTING: Large urban medical center and surrounding area. @entity1 : A sample of 58 healthy controls, 21 @entity1 with very mild DAT, and 29 @entity1 with mild DAT participated. DAT was diagnosed using validated clinical diagnostic criteria and staged according to the Clinical @entity303 Rating (CDR) Scale. MEASUREMENTS: Healthy controls and individuals with very mild DAT and mild DAT were administered a standardized on-road driving assessment over repeated times of testing. RESULTS: Subjects in the @entity7958 group (mild DAT) had a faster rate of receiving a rating of not safe on the driving test than subjects in the CDR=0 group (healthy controls; log rank test, P=.006), and the survival function of the CDR=0.5 group (very mild DAT) fell between those of the CDR=0 and @entity7958 groups. A Cox proportional hazards model indicated a significant difference in survival functions between the CDR=0 and @entity7958 groups after baseline age was controlled for (P<.001). Cox regression analysis also indicated that baseline age was a significant risk factor for a rating of "not safe" (P=.002). CONCLUSION: This study provides longitudinal evidence for a decline in driving performance over time, primarily in early-stage DAT, and supports the need not only for driving assessments, but also for reevaluation of individuals with very mild and mild DAT.
