Considerations in the treatment of XXXX with intrathecal baclofen.

@entity1 @entity508 @entity1772 @entity4372
PURPOSE: The etiology, diagnosis, and treatment of @entity508 of cerebral and spinal origin are reviewed, with emphasis on treatment with intrathecal @entity1772 and the role of pharmacists in @entity1 management. SUMMARY: Spasticity is a motor symptom characterized by neurologic etiology and involuntary, velocity-dependent @entity4372 . Its severity can vary, and its effects on activities of daily living and quality of life can be significant. Since the pathophysiology of @entity508 is not fully understood and since it is associated with many underlying conditions, its treatment can be complex, often requiring a multidisciplinary approach involving physicians, therapists, nurses, and pharmacists. Setting achievable goals based on individual @entity1 assessment and needs should drive therapy decisions. @entity1772 injection concentrate for intrathecal administration has FDA-approved labeling for use in @entity1 with severe @entity508 who are intolerant or unresponsive to other therapies. Due to its intrathecal delivery, adverse effects are minimized, and @entity1 response is enhanced. Pharmacists should remain knowledgeable about therapy management in @entity1 receiving treatment for @entity508 , including adverse event monitoring, infusion device complications, and dosage adjustments. If compounded intrathecal baclofen preparations are used, pharmacists should consider potency and sterility issues associated with high-risk level compounded sterile preparations and the potential for deviations in potency and sterility that may affect @entity1 safety and outcomes. CONCLUSION: When managing @entity508 symptoms, a comprehensive treatment plan as well as a multidisciplinary approach is required. Pharmacists should be well-versed in @entity508 treatment, particular intrathecal therapies since close monitoring, dosage adjustment, concentration accuracy, and product sterility are necessary for optimal @entity1 outcomes.
