Main differences in XXXX models: which should I use?

@entity1 @entity3604 @entity174 @entity2931 @entity14577 @entity170
@entity170 is a global public health problem currently affecting more than 200 million @entity1 worldwide. Major research efforts are being made to improve the outcomes for @entity1 with @entity170 . However, the treatment of @entity174 associated with @entity170 remains unsatisfactory. Animal models continue to be an important tool for establishing strategies to treat @entity3604 , and various methods of inducing @entity170 have been used. Investigators must select a model that best reflects the clinical problem being studied, and the underlying pathophysiology of the @entity170 in the target @entity1 group. In particular a model for @entity14577 should mimic a fall in @entity2931 and rise in osteoclast activity observed with this condition, whereas a model for @entity170 should mimic the fall in osteoblast activity. Unfortunately, there is no single all-encompassing model that precisely imitates the underlying @entity170 or the @entity174 patterns seen in @entity1 . As such the choice of species and model must be individualised to the scientific question being addressed. This article summarises general considerations when choosing an @entity3604 model and outlines existing models of @entity170 . The most appropriate model in a range of @entity3604 research scenarios are subsequently considered.
