Effects of ACNU and radiotherapy on XXXX .

@entity1 @entity137 @entity5 @entity4175 @entity11 @entity816 @entity463
A randomized clinical study of irradiation and irradiation combined with ACNU in the treatment of @entity11 was performed in order to determine if there was an enhancing therapeutic effect of ACNU given in addition to radiotherapy. An effect was defined as a reduction in @entity5 size, changes in neurological signs and performance status within 1 month after the completion of radiotherapy, or statistically improved survival times. Seventy-seven @entity1 from 14 neurosurgical clinics were included in this validated study group. Radiotherapy with a total dose of 5000 to 6000 rads, given in 25 to 30 subdoses, was applied to the whole brain and to a generous field surrounding the @entity5 . @entity1 who were assigned to receive chemotherapy were given ACNU intravenously once or twice during radiotherapy at a dose of 100 mg/sq m of body surface area. The response rate (more than 50% reduction of the @entity5 size) was 13.5% in the group treated by radiotherapy alone and 47.5% in the group with radiotherapy and ACNU. The hematological @entity137 was more severe in the group treated with radiotherapy and ACNU. Other @entity137 was mild and acceptable. The survival rates of @entity1 with @entity816 grade III and @entity463 multiforme at 36 months after the surgery were 48.9% and 0% for radiotherapy alone and 59.0% and 16.3% for radiotherapy plus ACNU, respectively. The differences between the survival curves were not significant at the p = 0.05 level. This study has demonstrated that, although the use of @entity4175 during radiotherapy suppressed @entity11 more than radiotherapy alone, the survival time was not extended significantly. It is necessary to continue to search for an effective chemotherapeutic regimen to prolong survival of @entity1 with @entity11 .
