Antimeasles immunoglobulin g for serologic diagnosis of XXXX .

@entity1 @entity8719 @entity9227 @entity805 @entity1274 @entity393 @entity16245
HYPOTHESIS: Persistent @entity805 infection of the otic capsule is suggested to be an etiologic factor in @entity8719 . @entity8719 is a disease of complex unknown etiology causing progressive conductive and/or @entity1274 ( @entity393 ). BACKGROUND: Diagnostic methods of @entity8719 are sensitive to ossicular chain fixation with low specificity for @entity16245 . METHODS: @entity9227 was extracted from stapes foot plates of clinically stapes fixation @entity1 (N = 213). @entity805 nucleoprotein RNA was amplified by reverse-transcriptase polymerase chain reaction. Amplification results were correlated to histologic findings in 49 cases. Antimeasles IgG levels of all clinically stapes fixation as well as control sera specimens were measured by enzyme-linked immunosorbent assay. RESULTS: Among clinically stapes fixation @entity1 , 141 stapes foot plates contained @entity805 RNA. Among 49 histologic specimens, viral RNA was detectable only in histologically otosclerotic stapes foot plates (n = 35). Histology for virus-negative foot plates (n = 14) excluded @entity8719 . Antimeasles IgG levels were significantly lower in the sera of @entity1 with virus-positive stapes than in control sera. CONCLUSIONS: Combination of decreased antimeasles IgG serum level and conductive @entity393 has a great specificity and sensitivity as a diagnostic method in the preoperative evaluation of @entity8719 . Low antimeasles IgG level indicates @entity8719 , whereas high level suggests non-otosclerotic ossicular chain fixations. Preoperative elucidation of the cause of a conductive @entity393 may suggest optional medical treatment in preference to surgical methods.
