Protective effects of cornus mas extract on in vitro fertilization potential in XXXX treated male @entity19 .

@entity19 @entity6822 @entity1234 @entity1499 @entity1865
Current study was aimed to evaluating protective effects of cornus mas fruit extract (CMFE) in @entity19 treated with @entity1499 ( @entity6822 ). For this purpose, 48 young mature male @entity19 were divided into 6 groups. Control group received only normal saline (0.1 mL per day, intraperitoneally), and the second group was administered @entity6822 (20 mg kg(-1) per week, intraperitoneally). The third, fourth and fifth groups received @entity6822 daily oral doses of 250, 500 and 1000 mg kg(-1) CMFE as well as @entity6822 . The sixth group was only given CMFE with a dose of 1000 mg kg(-1) per day, orally, for 35 days. Then, the animals were anesthetically euthanized and the sperms were separated from epididymis. DNA damage level, the amount of @entity1234 ( @entity1865 ) as well as in vitro fertility was evaluated. The number of sperms with damaged DNA and @entity1865 level in @entity6822 -treated group showed a significant increase compared to control group (p < 0.05). In groups receiving CMFE along with @entity6822 , DNA damage level and @entity1865 amount suggested a decrease in comparison with @entity6822 group (p < 0.05). Also, in vitro fertilization and embryonic development in @entity6822 -treated group was significantly lower than the control group, and the level of embryonic arresting was higher (p < 0.05). In groups which received CMFE along with @entity6822 , in vitro fertility and embryonic development was higher than @entity6822 group (p < 0.05) and the arrested embryos showed a decrease. This study suggested that cornus mas is able to ameliorate the side effects of @entity6822 .
