Liver regeneration and energetic changes in @entity35 following hepatic @entity1161 and XXXX by     P MRSI.

@entity8 @entity96 @entity1161 @entity9715 @entity35 @entity99 @entity855
BACKGROUND _ AIMS: @entity99 ( @entity99 ) is a poorly understood and potentially devastating complication of hepatic @entity1161 ( @entity1161 ) for @entity96 . Previous work has demonstrated that @entity8 ( @entity8 ) can ameliorate @entity99 in @entity35 . We hypothesized that @entity1161 inhibits generation of cellular @entity855 and suppresses hepatic regeneration. METHODS: To study the metabolic changes that occur in @entity99 with and without @entity8 , @entity9715 MRSI data were acquired in @entity35 treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with @entity8 (PHRT+ @entity8 ). RESULTS: Both [y - @entity855 ] and @entity855 /Pi @entity9715 MRSI signal ratio initially decreased and subsequently returned to baseline levels within 2 weeks after PH, which is consistent with other published data. Persistently reduced [y- @entity855 ] and @entity855 /Pi @entity9715 MRSI signal ratio were observed in @entity35 up to 20 weeks after PHRT. However, progressive increases in [y - @entity855 ] were observed over time in the group of @entity35 receiving PHRT+ @entity8 . Normal [y - @entity855 ] was observed 20 weeks after PHRT+ @entity8 (vs. PH alone), although, @entity855 /Pi levels did not return to normal after PHRT + @entity8 . Ex vivo histological studies were performed to confirm liver repopulation with transplanted hepatocytes and the amelioration of pathologic changes of @entity99 . CONCLUSIONS: These findings suggest that @entity9715 MRSI can be used to monitor the progress of @entity99 and its amelioration using transplanted hepatocytes to simultaneously restore metabolic function while replacing host hepatocytes damaged by @entity1161 .
