Pulmonary blood flow distribution after lobar XXXX injury: a PET study.

@entity235 @entity519 @entity3952 @entity5015
We evaluated the importance of @entity519 vasoconstriction as a mechanism for pulmonary blood flow reduction during unilobar @entity3952 lung injury in @entity235 . Pulmonary blood flow (PBF) and lung water were measured with positron emission tomography. Data from the injured left (LCL) and right (RCL) caudal lobes were compared in 23 @entity235 . Six @entity235 were used to demonstrate that endotoxin (15 micrograms/kg) prevents changes in regional PBF during selective @entity519 ventilation of the LCL. In 17 @entity235 , @entity3952 (OA, 0.015 ml/kg) was injected into the LCL through a balloon-wedged pulmonary arterial catheter. Five @entity235 received OA only (control group), eight received endotoxin (15 mcg/kg) before OA was administered (endotoxin group), and four were treated with @entity5015 ( @entity5015 ) after OA ( @entity5015 group). The base-line left-to-right PBF ratio (LCL/RCL PBF) was 1.01 +/- 0.11 (SD) for the control group and 1.07 +/- 0.16 for the @entity5015 group. One minute after OA, LCL/RCL PBF feel significantly (0.32 +/- 0.15 and 0.32 +/- 0.13 for the control and @entity5015 groups, respectively) before any significant increase in lung water was detected. In all 17 @entity235 that received OA, the LCL/RCL PBF remained severely reduced 60 min after OA compared with base-line values (0.41 +/- 0.15, 0.49 +/- 0.06, and 0.26 +/- 0.13 for the control, PGF1, and endotoxin groups, respectively) despite treatment with endotoxin or @entity5015 . Lung water measurements obtained 60 min after OA increased significantly (P less than 0.05) in the injured lobe (LCL) but not in the normal lobe (RCL) in all @entity235 groups, whereas PBF to the LCL remained significantly reduced.(ABSTRACT TRUNCATED AT 250 WORDS)
