Changes in various parameters of fibrinolysis in XXXX infused with tissue plasminogen activator: special reference to plasminogen activator inhibitor.

@entity1 @entity2002 @entity2289 @entity556 @entity7426 @entity3479
Tissue plasminogen activator ( @entity3479 ) purified from culture of @entity1 lung cells was infused over 30 min at the dose of 7.2 mg or 14.4 mg per @entity1 into @entity1 male volunteers. @entity3479 declined rapidly after the cessation of infusion with T1/2, alpha of about 4 min and T1/2, beta of about 40 min. The plasma @entity2002 and plasminogen did not change during and after the infusion of @entity3479 . The concentration of @entity7426 ( @entity7426 ) did not change but that of @entity7426 -plasmin complex increased to about 200 nM at the infusion of 14.4 mg/ @entity1 . Fragment D was hardly found at the infusion of 7.2 mg but some increase in the concentration of D was observed at the infusion of 14.4 mg. The concentration of free plasminogen activator inhibitor ( @entity2289 ) rapidly declined and kept low up to 150 min, and returned to normal the following day. The concentration of @entity3479 - @entity2289 complex increased rapidly, and slowly declined after the end of the infusion of @entity3479 , suggesting no significant release of @entity2289 in response to increase in plasma concentration of @entity3479 or @entity3479 - @entity2289 complex. The addition of @entity556 to the blood after withdrawal resulted in the significant formation of D-dimer, even at 150 min after the infusion. There was not hyperaggregability of platelets during and after the infusion of @entity3479 . These results suggest that the infusion of @entity3479 at the dose of 7.2 mg or 14.4 mg/ @entity1 for 30 min resulted in high fibrinolytic potential in the blood without the breakdown of @entity2002 or increase in @entity2289 .
