Relation of thickening of colon wall to pancreatic-enzyme treatment in XXXX .

@entity1 @entity548 @entity694 @entity1744 @entity1577
Fibrotic strictures of the colon in association with colon-wall thickening on abdominal ultrasound have been described in @entity1 with @entity1577 . We determined the prevalence of colon-wall thickening in 99 @entity1 with @entity1577 (aged 6 months to 17 years, 45 male) and 38 healthy controls (aged 1 month to 39 years, 21 male). In controls, peristalsis was uniformly rapid and maximum wall thickness of the fully relaxed colon was 0.8 mm (median 0.6 mm). 24% of the @entity1 had a @entity694 .5 mm or more (maximum 3.4 mm); 48% of @entity1 on high-strength pancreatin receiving more than 265 units/kg per day of protease had thickening of more than 1.5 mm compared with less than 12% of @entity1 on any other dose. @entity1 on high-strength pancreatin were 5.2 (95% CI 1.2-21) times more likely to have @entity694 .5 mm or more than @entity1 taking less than 265 units/kg per day of protease in a standard-strength preparation. This risk rose to 10 (2.5-39) times more likely if laxatives were taken with a high-strength preparation. Lipase or amylase intake, age, sex, genotype, and other medical or drug history were not significantly associated with colon-wall thickening. 1 @entity1 required a hemicolectomy for @entity1744 and another developed @entity548 . In 17 @entity1 , 2 months after stopping high-strength, high protease, preparations and efforts to reduce enzyme intake, colon-wall thickness had regressed from a median 2.0 mm (range 1.0-3.4) to 1.8 mm (0.9-2.7) (p = 0.005). The use of high-strength pancreatin preparations in conjunction with a high protease intake probably causes thickening of the wall of the colon.
