The @entity72041 - XXXX module integrates cold and @entity2271 signaling to activate the CBF-COR pathway in Arabidopsis.

@entity2272 @entity2271 @entity72041 @entity1131 @entity72043 @entity67742 @entity72042
UNASSIGNED: Various environmental stresses limit plant growth, development, and reproductive success. Plants have therefore evolved sophisticated adaptive responses to deal with environmental challenges. The responses of plants to environmental stresses are mainly mediated by @entity2271 ( @entity2272 )-dependent and @entity2272 -independent signaling pathways. While these two pathways have been implicated to play discrete roles in abiotic stress responses, accumulating evidence suggests that they are also intertwined. Here, we report that an R2R3-type MYB transcription factor, @entity72041 , integrates the @entity2272 and cold signaling pathways. In addition to its role in @entity2272 -mediated drought responses, @entity72041 is also induced by cold stress in an @entity2272 -independent manner and subsequently activates freezing tolerance. Notably, @entity72041 regulates @entity1131 ( @entity1131 ) genes by binding to their promoters. The @entity1131 proteins, in turn, interact with C-REPEAT BINDING FACTOR (CBF) upstream regulators, such as @entity72042 ( @entity72042 ), @entity72043 , and @entity67742 ( @entity67742 ). The specific interactive networks of HHPs with the CBF upstream regulators are necessary to facilitate transcriptional activation of the CBF regulon under stressful conditions. Together, the @entity72041 - @entity1131 module integrates @entity2272 -dependent and @entity2272 -independent signals and activates the CBF pathway, ensuring plant adaptation to a wide range of adverse environmental fluctuations.
