Oncogene-Induced Senescence in XXXX -an Immunohistochemical Study.

@entity986 @entity5 @entity3544 @entity2124 @entity977 @entity652
UNASSIGNED: Oncogene-induced senescence (OIS) serves as an initial barrier to @entity5 development, being proposed as a possible explanation for the usually benign behavior of the @entity977 . We aimed to explore the immunohistochemical expression of the OIS markers, senescence-associated lysosomal b-galactosidase (SA-b-GAL), @entity986 , and @entity3544 in different types of 345 @entity977 and compared it with the expression in the normal pituitary and in the specimens from the repeated surgeries. SA-b-GAL was overexpressed in the @entity977 , compared to the normal pituitaries. @entity2124 ( @entity2124 ) producing @entity652 showed the strongest SA-b-GAL, with densely granulated (DG)- @entity2124 @entity652 more reactive than the sparsely granulated (SG). Nuclear @entity3544 was decreased in the @entity652 , except for the SG-GH @entity652 that had higher @entity3544 than the normal pituitaries and the other @entity652 . @entity986 was significantly lower in the @entity652 , without type-related differences. SA-b-GAL was slightly lower and @entity986 slightly higher in the recurrences. Our findings indicate alterations of the senescence program in the different types of @entity977 . Activation of senescence in the @entity977 presents one possible explanation for their usually benign behavior, at least in the @entity2124 @entity652 that show a synchronous increase of two OIS markers. However, subdivision into @entity2124 @entity652 subtypes reveals differences that reflect complex regulatory mechanisms influenced by the interplay between the granularity pattern and the hormonal factors, with possible impact on the different clinical behavior of the SG- and DG- @entity2124 @entity652 subtypes. @entity986 seems to have a more prominent role in the pituitary tumorigenesis than in the senescence. Recurrent growth in a subset of the @entity977 is not associated with consistent changes in the senescence pattern.
