Effects of preventive surgery for unruptured XXXX on attention, executive function, learning and memory: a prospective cohort study.

@entity1 @entity10334 @entity438
BACKGROUND: We prospectively evaluated the effects of preventive surgery for unruptured @entity438 on attention, executive function, learning and memory. METHODS: Between March 2012 and June 2013, 56 @entity1 were recruited for this study. Fifty-one @entity1 met the inclusion criteria and were enrolled. Inclusion criteria were as follows: (1) age    <=65  years and (2) planned microsurgery or endovascular surgery for unruptured @entity438 . Exclusion criteria were as follows: (1) preoperative intelligence quotient   <80 (n   =   3); (2) initial modified Rankin scale   >= 1 (n   =   1); (3) loss to follow-up (n   =   1). An auditory controlled continuous performance test (ACCPT), word-color test (WCT) and verbal learning test (VLT) were performed before and after (6  months) preventive surgery. RESULTS: ACCPT (attention), WCT (executive function) and VLT (learning and memory) scores did not change significantly between the pre- and postoperative evaluations. The ACCPT, WCT, total VLT scores (verbal learning) and delayed VLT scores (memory) did not differ significantly between @entity1 undergoing microsurgery and those undergoing endovascular surgery. However, ACCPT, WCT and delayed VLT scores decreased postoperatively in @entity1 with @entity10334 on preoperative FLAIR images (OR 9.899, p   =   0.041; OR 11.421, p   =   0.006; OR 2.952, p   =   0.024, respectively). CONCLUSIONS: Preventive surgery for unruptured @entity438 did not affect attention, executive function, learning or memory. However, @entity1 with @entity10334 on FLAIR images might be prone to deficits in attention, executive function and memory postoperatively, whereas learning might not be affected.
