Regulation of T cell receptor gamma gene expression by cytokines in XXXX hematopoietic cells.

@entity2304 @entity14541 @entity19 @entity3019 @entity12810 @entity58
@entity19 @entity3019 -dependent myeloid cell lines express transcripts from non-rearranged @entity12810 gamma genes and this expression is dependent upon @entity3019 . To investigate this observation in general terms we examined various @entity3019 dependent cell lines for @entity12810 gamma gene expression. We also examined various cytokines to test their potential to induce @entity12810 gamma gene expression. All @entity3019 dependent cell lines expressed @entity12810 gamma transcripts. The @entity3019 induced expression was sensitive to protein synthesis inhibitors. This demonstrated that the @entity12810 gamma genes belong to the early growth factor response class. @entity3019 , @entity58 , @entity2304 and Erytropoietin (EPO), but not @entity14541 , induced @entity12810 gene expression. 32D cells transfected with the IL-2 beta chain receptor became responsive to IL-2 as a growth factor and induced @entity12810 gamma gene expression. The induction of @entity12810 gamma gene expression by the cytokines was not correlated to their growth promoting activity. This indicated different signaling pathways.
