MicroRNA-100 expression is independently related to biochemical recurrence of XXXX .

@entity1 @entity263 @entity26719 @entity5 @entity1067 @entity22076 @entity10075 @entity105 @entity1486 @entity3373
PURPOSE: Abnormal miRNA expression has emerged as crucial factors in @entity105 and is important in the comprehension of @entity263 behavior. We determined the correlation of miRNA expression profiles with @entity263 progression. MATERIALS AND METHODS: We studied frozen specimens from 49 @entity1 treated for @entity263 with radical prostatectomy. We intentionally chose 28 @entity1 without and 21 with biochemical recurrence, defined as @entity1486 greater than 0.2 ng/ml. The expression of 14 miRNAs was determined by quantitative reverse transcriptase-polymerase chain reaction. All radical prostatectomy specimens were studied in toto to determine @entity5 volume, Gleason score and 2002 TNM pathological stage. Benign prostate tissue from @entity1067 served as a control. RESULTS: Four miRNAs were related to @entity5 recurrence. Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of @entity26719 , @entity3373 , @entity22076 and @entity10075 , respectively. When considering statistically significant clinical variables on univariate analysis of biochemical-free survival, @entity1486 and @entity5 volume, results revealed that @entity26719 and @entity5 volume were independently related to @entity5 recurrence. CONCLUSIONS: A high level of @entity26719 is related to biochemical recurrence of @entity263 in @entity1 treated with radical prostatectomy. The role of @entity26719 during @entity105 must be resolved in future studies to better understand the molecular pathways in which @entity26719 is involved. This may open the possibility of using it as a prognostic marker and inspire the development of a target drug.
