Patterns of pharmacotherapy in XXXX hospitalised for @entity712 .

@entity1 @entity117 @entity712 @entity1289
BACKGROUND: In the 1990s, a number of cardiovascular drugs were evaluated in randomised clinical trials. Treatment guidelines for @entity712 were modified to include these evidence-based treatments. AIM: To evaluate the impact of new medical treatments for @entity712 between 1990 and 1998. METHODS AND RESULTS: A retrospective cohort study of 2764 @entity1 with a first hospital admission for @entity712 between 1990 and 1998. The percentage of @entity1 treated with different cardiovascular drugs after hospitalisation was calculated and compared over time. Use of loop diuretics remained steady approximately 80%, digoxin decreased from 57.6 to 42.7%, @entity1289 ( @entity1289 ) inhibitors showed a slight increase from 49.8 to 54.8%, beta-blockers almost tripled from 11.3 to 28.7%, low dose prophylactic @entity117 quadrupled from 9.9 to 39.9%. Kaplan-Meier survival estimates showed highest continuation rates of drug treatment for antithrombotics and diuretics, intermediate for digoxin and @entity1289 inhibitors and low for beta-blockers. More than a quarter of the users discontinued beta-blockers in the first year after hospitalisation. CONCLUSIONS: We observed an increase in the prescribing of several important drug classes, reflecting changes in treatment guidelines during the study period. However, our findings show that not all @entity1 were receiving optimal treatment. More research into the reasons for this is warranted.
