Saline vs XXXX Irrigations after Drain Placement for @entity698 : A Prospective Randomized Trial.

@entity1 @entity2756 @entity868 @entity698 @entity6177 @entity1456
BACKGROUND: Emerging data suggest instillation of @entity1456 (tPA) is safe and potentially efficacious in the treatment of @entity6177 . To date, prospective comparative data are lacking in @entity1 . Therefore, we conducted a randomized trial comparing abscess irrigation with tPA and irrigation with saline alone. STUDY DESIGN: After IRB approval, @entity1 with an abscess secondary to @entity698 who had a percutaneous drain placed for treatment were randomized to twice-daily instillation of 13 mL 10% tPA or 13 mL normal saline. All @entity1 were treated with once-daily dosing of @entity2756 and @entity868 throughout their course. The primary end point variable was duration of hospitalization after drain placement. Using a power of 0.8 and an a of 0.05, a sample size of 62 @entity1 was calculated. RESULTS: Sixty-two @entity1 were enrolled between January 2009 and February 2013. There were no differences in demographics, abscess size, abscess number, admission WBC, or duration of symptoms. Duration of hospitalization after drainage was considerably longer with the use of tPA. There was no difference in total duration of hospitalization, days of drainage, or days of antibiotics. However, medication charges were higher with tPA. CONCLUSIONS: There are no advantages to routine tPA flushes in the treatment of @entity6177 secondary to @entity698 in @entity1 .
