Association between the @entity5075 32-bp deletion allele and late onset of XXXX .

@entity1 @entity161 @entity5075
OBJECTIVE: The 32-bp deletion allele in @entity5075 has been associated with several immune-mediated diseases and might be implicated in @entity161 as well. METHOD: The authors genotyped DNA samples from 268 @entity161 @entity1 and 323 healthy subjects. Age at first admission to a psychiatric hospital department served as a measure of disease onset. RESULTS: @entity1 and comparison subjects differed marginally in their genotype distribution, with a slightly higher frequency of the deletion allele seen in the @entity1 . The authors found the deletion allele to be associated with higher age at first admission. After age at first admission was analyzed as a continuous variable, it was dichotomized using 40 years as the cutoff. With this approach the authors found that genotype distributions of @entity1 with age at first admission above the cutoff (possible cases of late-onset @entity161 ) and healthy subjects differed significantly. This was reflected in an increased frequency of the deletion allele in the @entity1 subgroup. @entity1 with ages at first admission below and above 40 years significantly differed in distribution of genotypes and alleles, with an overrepresentation of the deletion allele in the latter subgroup of @entity1 . CONCLUSIONS: These findings suggest that the @entity5075 32-bp deletion allele is a susceptibility factor for @entity161 with late onset. Alternatively, the @entity5075 32-bp deletion allele may act as a modifier by delaying the onset of @entity161 without affecting the disease susceptibility.
