The Effect of Spinal Cord Stimulation on XXXX .

@entity17202 @entity410 @entity602 @entity302 @entity35 @entity1118 @entity5093
OBJECTIVE: @entity602 ( @entity602 ) has been applied to relieve @entity1118 for decades. Recent studies suggested that @entity602 also might alleviate @entity302 , but the most effective stimulation parameters are not known. The objective of this work was to investigate the role of @entity602 frequency in alleviating spike-and-wave (SW) discharges induced in @entity35 by @entity5093 ( @entity17202 ) infusion. MATERIALS AND METHODS: The SW discharges were induced in nine @entity35 . An epidural electrode was placed in the spinal canal at the cervical level. @entity602 was delivered at four frequencies (30, 80, 130 and 180   Hz) and compared with control intervals without stimulation. The effect was evaluated by analyzing electrocorticographic and intracortical (IC) signals. The means of normalized SW spike power (mSP) and frequency (mSF) were derived from the IC recordings and used to estimate the @entity410 severity. RESULTS: Compared with the control intervals, @entity602 conducted at 30   Hz significantly increased the mSP and mSF indicating an increase of the SW spiking activity; 80   Hz did not induce significant changes of the features. In contrast, 130- and 180-Hz @entity602 reduced both mSP and mSF significantly indicating a reduction of the SW spiking activity. CONCLUSIONS: The present results showed that 130-Hz and 180-Hz @entity602 reduced the SWs power and frequency which may indicate an anticonvulsive effect of these @entity602 frequencies, whereas 30-Hz @entity602 induced the opposite effects and, therefore, may be proconvulsive.
