Ten years of experience with transgastric necrosectomy for walled-off XXXX in acute @entity788 .

@entity1 @entity1143 @entity788 @entity548 @entity39 @entity6 @entity5990 @entity8479 @entity285 @entity356
INTRODUCTION: The aim of this study was to report our results with open transgastric necrosectomy for walled-off @entity39 in acute @entity788 over a period of ten years. METHODS: @entity1 operated at the department from 2003 until 2012 were studied retrospectively. RESULTS: A total of 50 @entity1 had surgery. The median age was 55 years (range: 17-79 years). The presumed aetiologies were: @entity5990 (n = 28), @entity285 (n = 8) and other causes (n = 14). The median preoperative stay at hospital was 50 days (range: 2-150 days). Bacterial culture from the @entity39 tissue was positive in 26 @entity1 (52%), negative in 15 @entity1 (30%); and in nine @entity1 , no information on this was available. In all, 22 @entity1 (44%) had one or more incidents (i.e. @entity8479 , @entity548 , new abscess, @entity1143 or delayed @entity356 ) where additional invasive therapy was needed. Ten @entity1 (20%) died during their admission to our department. In total, 18 (45%) @entity1 developed late complications defined as endocrine and/or exocrine malfunction of the pancreas ( @entity6 (n = 10), exocrine insufficiency (n = 4), both @entity6 (n = 4)). CONCLUSION: Acute @entity788 with walled-off @entity39 has a high mortality rate. Need for additional therapy following necrosectomy was associated with fatal outcome. Endocrine and exocrine insufficiency was often seen at follow-up. FUNDING: none. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency via Region of Southern Denmark (case no. 13/29319).
