Postcardiac surgical XXXX in the aged using diffusion-weighted magnetic resonance imaging.

@entity1 @entity64 @entity2806 @entity63 @entity75 @entity73 @entity16 @entity149
BACKGROUND: Cardiac surgery is associated with @entity75 . While 1% to 2% of @entity1 experience @entity64 , @entity73 are seen in more than half of @entity1 . Given the high incidence of @entity73 , it has become the endpoint of many cardiac surgery investigations. Because the elderly are at highest risk, this investigation sought to determine if there is a relationship between new @entity63 changes demonstrated by diffusion-weighted magnetic resonance imaging (DW-MRI) and postoperative @entity73 in older @entity1 . METHODS: Fifty cardiac surgical @entity1 (>65 years of age) underwent preoperative and postoperative neurocognitive examinations, including four to six week, postdischarge, follow-up. This evaluation assessed higher cortical function, memory, attention, concentration, and psychomotor performance. Objective evidence of acute cerebral @entity63 events was identified using DW-MRI. Scans were analyzed by a neuroradiologist blinded to clinical status and cognitive outcomes. RESULTS: Among @entity1 with a mean age of 73 years, 88% demonstrated @entity73 in the postoperative testing period while 32% showed evidence of acute perioperative @entity2806 by DW-MRI. At postdischarge follow-up, 30% of @entity1 showed @entity73 . However, @entity73 assessed postoperatively, or at a four to six week follow-up, was unrelated to the presence or absence of DW-MRI detected @entity2806 . CONCLUSIONS: Postoperative @entity149 , assessed by standard means, is unrelated to @entity2806 detected by DW-MRI. This strongly suggests that @entity73 after cardiac surgery is a function of underlying @entity1 factors rather than perioperative @entity63 events. This observation has broad implications for future investigation of strategies to prevent cardiac surgery-related @entity16 .
