Repeated intraperitoneal instillation of @entity1343 for the management of XXXX after laparoscopic cholecystectomy.

@entity1 @entity1219 @entity14340 @entity1337 @entity2963 @entity6882 @entity1343 @entity158 @entity9348 @entity282 @entity3575
BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity2963 . @entity282 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity1337 , intraperitoneal local anesthetic administration optimizes @entity1337 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity1 was randomized to receive either intraperitoneal analgesic ( @entity9348 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity1343 0.5% were infused intraperitoneally in the @entity9348 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity1219 were administered in the corresponding points of time. Differences in @entity158 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9348 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity3575 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity6882 and the percentage of the @entity1 that requested rescue @entity1337 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity14340 for postoperative @entity1337 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity1343 significantly decreased @entity282 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.
