HLA class-II allele frequencies in Turkish @entity0 XXXX .

@entity1 @entity0 @entity233 @entity3098 @entity5 @entity1533 @entity1722
Class-II human leukocyte antigens (HLA) present @entity5 antigenic peptides on the cell surface in order to be recognized by T lymphocytes. Thereby, these molecules can play an important role in the immune response to @entity0 antigens. The aim of this study was to determine the relation between @entity0 and HLA class-II alleles in @entity233 . The study groups consisted of 69 @entity0 @entity1 and 45 healthy controls. Typing of @entity1533 and @entity3098 from DNA samples was performed by Sequence Specific Oligonucletide Hybridisation. Significant negative correlations were observed between @entity1533 03 and @entity3098 02 alleles and @entity0 (p1 = 0.019; p2 = 0.019) and also between @entity3098 02 allele and postmenopausal @entity0 (P = 0.022) and @entity1722 positivity (P = 0.038). Furthermore, there was a significant positive correlation between @entity1533 13 and @entity3098 06 alleles and progesteron receptor positivity (p1 = 0.012; p2 = 0.001); and a significant negative correlation between @entity3098 03 allele and progesteron receptor positivity (P = 0.009) in @entity0 . Additionally, another significant positive correlation was seen between @entity1533 04 allele and @entity1722 positivity (P = 0.036). As a result, while @entity1533 03, @entity3098 02, @entity1533 13, and @entity3098 06 alleles were found to be involved in protectiveness against @entity0 and good prognosis; @entity3098 03 and @entity1533 04 alleles were found to be involved in poor prognosis. In conclusion, by determining allele types showing predisposition to @entity0 , a systematical screening and follow up systems can be developed for @entity1 who are at high risk.
