The XXXX as a model for healing studies after partial nephrectomy.

@entity1 @entity1707 @entity742 @entity1133 @entity6693 @entity6986 @entity1011
BACKGROUND: The @entity1707 has been considered the best model for renal surgery. However, recent research has demonstrated that the kidney of @entity1707 heals differently from that of @entity1 . The objective of this study was to evaluate @entity742 as an alternative animal model for studying collecting system healing after laparoscopic partial nephrectomy. MATERIALS AND METHODS: The caudal pole of the left kidney was removed from eight female adult @entity742 using laparoscopic partial nephrectomy. Monopolar energy was used for hemostasis only in the parenchyma, avoiding coagulation near the collecting system, which was left opened. After 14  d, all animals were euthanized, and their left kidney was removed. Serum levels of @entity1133 and @entity1011 were assessed preoperatively and postoperatively (on days 2, 6, 10, and 14), and peritoneal fluid samples were collected during necropsy for @entity1133 and @entity1011 evaluation. An ex  vivo retrograde pyelogram was performed, and a retrograde injection of @entity6693 ink was administered to evaluate urinary leakage. Samples from the operated pole were analyzed using histologic methods. RESULTS: During necropsy, an @entity6986 surrounding the operated kidney was observed in one animal. Peritoneal fluid levels of @entity1133 and @entity1011 were elevated. Retrograde pyelograms exhibited contrast-medium extravasation through the operated pole in all kidneys. The opened collecting system was also confirmed by @entity6693 ink injection. The operated pole was covered by collagenous tissue and adhered to adjacent organs. CONCLUSIONS: @entity742 should be considered as an adequate experimental model for research on collecting system healing after partial nephrectomy.
