Outcomes following surgical intervention for impending and gross instability caused by XXXX in the spinal column.

@entity1 @entity6872 @entity3478 @entity5 @entity1582
UNASSIGNED: OBJECT @entity1582 is the most common @entity5 of the spine and is the most common primary @entity3478 . Although spinal @entity1582 is classically a radiosensitive lesion, clinical or radiographic signs of instability merit surgical intervention. The authors present the epidemiology, surgical indications, and outcome data of a series of consecutive cases involving 31 surgically treated @entity1 with diagnoses of @entity1582 and @entity6872 of the spine (the largest such series reported to date). METHODS Surgical instability was the criterion for operative intervention in this @entity1 cohort. The Spinal Instability Neoplastic Score (SINS) was used to make this assessment of instability. The cases were analyzed using location of the lesion, spinal levels involved, Frankel score, adjuvant therapy, functional outcome, and @entity1 survival. RESULTS All @entity1 undergoing surgical intervention were determined to have indeterminate or gross spinal column instability according to SINS criteria. The median survival was 78.9 months. No significant difference in survival was seen for @entity1 with higher SINS scores or for older @entity1 (> 55 years). There was a statistically significant difference in survival benefit observed for @entity1 receiving chemotherapy and radiation versus radiation alone as an adjuvant to surgery (p = 0.02). CONCLUSIONS In this 10-year analysis, the authors report outcomes of surgical intervention for @entity1 with indeterminate or gross spinal instability due to @entity1582 and @entity6872 of the spine with improved neurological function following surgery and low rates of instrumentation failure.
