Prospective randomized comparison of cooled radiofrequency versus standard radiofrequency energy for ablation of typical XXXX .

@entity1 @entity956 @entity616 @entity6470
In @entity1 with @entity956 , conventional @entity6470 ablation may not result in complete @entity616 . This prospective, randomized study tested the hypothesis that the cooled @entity6470 ablation is safe and facilitates the achievement of @entity616 with fewer @entity6470 applications than with standard ablation for typical @entity956 . Isthmus ablation was performed in 59 @entity1 (40 @entity1 , 64 +/- 14 years) with @entity956 using standard @entity6470 (n = 31) or cooled @entity6470 (n = 28) catheters with crossover after 12 unsuccessful @entity6470 applications. The endpoint was bidirectional @entity616 or a total of 24 unsuccessful @entity6470 applications. After the first 12 @entity6470 applications, 17 (55%) of 31 standard @entity6470 and 22 (79%) of 28 cooled @entity6470 @entity1 had bidirectional @entity616 (P < 0.05). After the remaining @entity1 crossed over to the alternate @entity6470 ablation system and underwent up to 12 more @entity6470 applications, bidirectional @entity616 had been demonstrated in 27 (87%) of 31 standard @entity6470 and 25 (89%) of 28 cooled @entity6470 @entity1 (P = NS). Isthmus block was not achieved within 24 @entity6470 applications in four standard and three cooled @entity6470 @entity1 . Mean measured tip temperatures for cooled @entity6470 were lower than for standard @entity6470 (38.5 degrees C +/- 6.98 degrees C vs 57.2 degrees C +/- 7.42 degrees C, P < 0.0001). Peak temperatures were also lower for cooled @entity6470 compared to standard @entity6470 (45.7 degrees C +/- 22.7 degrees C vs 63.4 degrees C +/- 9.87 degrees C, P < 0.0001). Importantly, mean power delivered was significantly higher for cooled than for standard @entity6470 (42.3 +/- 9.48 vs 34.0 +/- 14.0 W, P < 0.0001). There were no serious complications for either ablation system. During a 12.8 +/- 3.76-month follow-up, there were two @entity956 in the cooled @entity6470 group and four in the standard @entity6470 group (P = NS). In @entity1 with @entity956 , ablation with the cooled @entity6470 catheter is as safe as, and facilitates creation of bidirectional @entity616 more rapidly than, standard @entity6470 ablation.
