Postoperative irradiation in XXXX : the Rambam Medical Center experience.

@entity1 @entity137 @entity189 @entity1578 @entity1358
OBJECTIVE: This study evaluated the results of postoperative adjuvant radiotherapy in @entity1 with @entity1358 ( @entity1358 ). @entity1 : Eighty-six @entity1 (median age, 60 years) with @entity1358 treated by radical nephrectomy were evaluated for the efficacy of postoperative radiotherapy. Twenty-four percent of @entity1 had stage T2, 35% T3a, 36% T3b and 5% T4 disease. Seventy-seven percent had clear cell @entity189 and 23% granular cell or spindle and mixed cell @entity189 . Radiotherapy was given to the renal bed and adjacent lymphatic basin at a median dose of 46 Gy. RESULTS: Thirty-two (37%) @entity1 relapsed: 27 (84%) had systemic relapse only and five (16%) had local and systemic relapse; all @entity1 of the latter group had stage T3b disease. The 10-year disease-free and overall survival was 40% and 42%, respectively. Tumor invasion of the renal vessels and stage of disease were correlated with survival. Side effects of radiotherapy were mainly gastrointestinal, but one @entity1 who received right abdominal irradiation died because of @entity1578 . CONCLUSION: The results of our study are comparable with those reported in the literature. Since postoperative irradiation did not improve the survival of @entity1 with @entity1358 and showed @entity137 , it is not recommended.
