Studies on the interaction of rheumatoid factor with XXXX crystals and case report of coexistent tophaceous gout and @entity309 .

@entity1 @entity19577 @entity3811 @entity8038 @entity309 @entity414
Gout and classical @entity309 rarely coexist. We report a @entity1 with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of @entity414 crystals (MSU) by binding of rheumatoid factor ( @entity19577 ). This was studied with a purified @entity309 factor ( @entity19577 ) with specificity for IgG. The @entity19577 bound preferentially to MSU coated with IgG in contrast with the IgM control. Inhibition of the neutrophil chemiluminescence (CL) response to IgG-coated MSU was observed at concentrations of @entity19577 that had no effect on the CL response to uncoated crystals. Neutrophil activation was not altered by coating crystals with an IgM control at the same concentration. These data suggest that @entity19577 may bind to antigenic determinants on exposed Fc of adsorbed IgG and block the interaction of crystal-bound IgG with Fc receptors. Although @entity8038 by @entity19577 may modify the expression of @entity3811 , it is unlikely to be the sole explanation for the dissociation between gout and @entity309 .
