Role of mast cells in XXXX .

@entity58884 @entity219 @entity12006 @entity344 @entity28285 @entity281 @entity3088 @entity13629 @entity56 @entity112 @entity37474 @entity9992 @entity750 @entity3092 @entity6850
The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with @entity344 . Gastrointestinal mast cells are involved in many pathologic effects, such as @entity56 . On the other hand, they also play a protective role in defense against @entity281 . Thus, they have both positive and negative effects, but presently the mechanisms that control the balance of these various effects are poorly known. It has been suggested that stabilization of mast cells may be a key mechanism to protect the gastrointestinal tract from injury. Few molecules are known to possess both mast cell stabilizing and gastrointestinal cytoprotective activity. These include @entity219 compounds, @entity9992 , @entity58884 , @entity6850 , aloe vera, certain @entity3088 such as @entity3092 , some sulfated proteoglycans such as @entity12006 and @entity37474 . @entity37474 , a @entity28285 isolated from Artemisia douglasiana Besser, exhibits anti-inflammatory and gastrointestinal cytoprotective action. The @entity13629 stimulates mucus production, and inhibits @entity112 and @entity750 release from intestinal mast cells. The @entity13629 could act as a selective mast cell stabilizer by releasing cytoprotective factors and inhibiting pro-inflammatory mast cell mediators.
