Effect of chronic XXXX treatment on cardiovascular and behavioral parameters in @entity19 .

@entity4360 @entity4836 @entity19
Experiments were performed to determine the effect of chronic low-dose @entity4836 (PB) treatment on blood @entity4360 ( @entity4360 ), cardiovascular (CV) function, and behavior in C57BL/6J male @entity19 . Chronic carotid arterial catheters were used for long-term CV measurements and for collection of blood samples. Separate groups of @entity19 were used for behavioral open field tests. PB was administered subcutaneously using osmotic minipumps at 1 and 3 mg/kg/day for 7 days. Blood pressure and heart rate (HR) were measured continuously for 24 h before treatment and on Days 3 and 7 after minipump insertion. Blood samples were collected on the same days. Mean arterial pressure (MAP) of the control group was 108+/-2 and 104+/-2 mm Hg during the dark and light periods, respectively. HR was 510+/-18 and 493+/-19 beats/min during the dark and light periods, respectively. PB treatment had no effect on MAP or HR in either dark or light period. Basal @entity4360 activity was 0.42+/-0.1 micromol/min/ml, with no changes observed with PB at 1 mg/kg/day. The higher PB dose (3 mg/kg/day) decreased blood @entity4360 activity by 85% on Day 7. Despite the reduction in blood @entity4360 activity, there were no alterations in open field behaviors (locomotor activity, rearing, distance traveled, rest time, number of entries, and pokes). In conclusion, chronic low-dose PB exposure decreased blood @entity4360 activity but had no effect on CV function or behavior in @entity19 .
