Relation between dietary fiber consumption and @entity2002 and XXXX : The National Heart, Lung, and Blood Institute Family Heart Study.

@entity1 @entity2002 @entity2289 @entity299 @entity453 @entity65
Considerable evidence suggests that high plasma concentrations of @entity2289 ( @entity2289 ) and @entity2002 increase the risk of @entity65 . Recent studies report beneficial effects of dietary fiber on @entity453 , although the mechanisms by which high fiber intake reduces the risk of @entity299 are not well understood. This study examined the relation of dietary fiber intake to @entity2289 and @entity2002 concentrations in 883 @entity1 and 1116 @entity1 aged 50.4 +/- 13.8 and 52.1 +/- 13.7 y, respectively, in the National Heart, Lung, and Blood Institute Family Heart Study. Diet was assessed with a semiquantitative food-frequency questionnaire. The natural logarithm was used to transform @entity2289 because of a skewed distribution. In the first through fifth age- and energy-specific quintiles of fiber intake, mean (ln) @entity2289 was 6.09, 5.91, 5.88, 5.82, and 5.67 pmol/L, respectively, for @entity1 and 5.50, 5.37, 5.39, 5.23, and 5.18 pmol/L, respectively, for @entity1 . Multiple regression showed that when the lowest was compared with the second, third, fourth, and fifth age- and energy-specific quintiles of fiber intake, (ln) @entity2289 was 0.21, 0.25, 0.22, and 0.32 pmol/L lower in @entity1 (P for trend = 0.009) and 0.08, 0.06, 0.14, and 0.20 pmol/L lower in @entity1 (P for trend = 0.037), respectively, with anthropometric, lifestyle, and metabolic factors adjusted for. No significant association was found between fiber intake and @entity2002 . Waist-hip ratio did not modify the relation of fiber intake to @entity2289 (P for interaction = 0.39 for @entity1 and 0.36 for @entity1 ). These data suggest that higher fiber intake is inversely associated with @entity2289 , but not with @entity2002 concentration.
