Long-term safety of XXXX in @entity5477 : results of an 8-year followup study.

@entity1 @entity5477 @entity1866 @entity1482 @entity3427
BACKGROUND: @entity1482 has been used for over 20 years as an antiandrogen in the treatment of @entity5477 and @entity3427 . No long-term studies of the safety of @entity1482 used in this manner have been published. We present a study of the long-term safety and tolerance of @entity1482 in 91 @entity1 with @entity5477 who were followed for up to 8 years. METHODS: A survey questionnaire was sent to 210 @entity1 , and a comparison chart review of all @entity1 to whom the survey was sent was made. RESULTS: Ninety-one completed surveys were analyzed, comprising 506 @entity1 -years of followup and 200 @entity1 -years of @entity1482 exposure. Mean treatment length was 28.5 months (range = 0.5-122 months). During the 8-year followup period, there were no cases of serious illness attributable to @entity1482 use. Side effects were present in 59% and resulted in cessation of the drug in 15%. Diuretic effect and @entity1866 were the most common adverse effects. CONCLUSIONS: After 200 @entity1 -years of exposure to @entity1482 and 506 @entity1 -years of followup over 8 years, no serious illnesses thought to be attributed to @entity1482 were reported. The long-term use of @entity1482 in the treatment of @entity5477 in @entity1 appears to be safe. Side effects, however, are common, although not usually a cause for stopping the drug.
