Upper @entity5 , uncomplicated XXXX , and the age threshold for early endoscopy.

@entity1 @entity353 @entity548 @entity417 @entity5 @entity391 @entity2210 @entity1282
OBJECTIVES: We sought to determine the frequency with which @entity1 with @entity5 present with uncomplicated @entity2210 and to determine the impact of changing the threshold for early endoscopy from 45 to 55 yr, as has recently been recommended in European studies. METHODS: Three hundred forty-one @entity1 with @entity5 at two Milwaukee teaching hospitals were identified from electronic databases. Trained physician-investigators reviewed the charts using a specifically designed questionnaire. Staging of @entity5 was performed using the TNM classification to determine operability. Uncomplicated @entity2210 was defined as @entity2210 without alarm symptoms/signs ( @entity1282 , @entity391 , @entity353 , early satiety, @entity548 , or @entity417 ). RESULTS: There were 341 @entity1 with @entity5 with a mean age of 68 yr (range = 22-94). Twenty-one @entity1 were younger than 45 and 65 were under 55. Uncomplicated @entity2210 was the presenting symptom in five of 65 (7.7%) @entity1 younger than 55 and one of 21 (4.8%) @entity1 under 45 (p = 0.99). Five @entity1 55 or younger presented with uncomplicated @entity2210 . All had advanced, inoperable disease (stage III or higher). CONCLUSIONS: 1) In a racially diverse United States population, upper @entity5 presenting without alarm symptoms is uncommon. 2) Raising the threshold for immediate endoscopy in uncomplicated @entity2210 from age 45 to 55 increases the risk of missing an underlying @entity5 but may not affect outcome, as incurable disease was present at diagnosis within a few weeks of the onset of symptoms.
