XXXX -specific helper T cell clones from subjects resistant to infection by @entity380 are Th0/2.

@entity1 @entity383 @entity379 @entity380 @entity2040
Although T helper cells play a critical role in @entity1 immunity against schistosomes, the properties of the T lymphocytes that govern resistance and pathogenesis in @entity1 @entity2040 are still poorly defined. This work addresses the question as to whether @entity1 resistance to @entity380 is associated with a particular T helper subset. Twenty-eight CD3+, CD4+, CD8- parasite-specific T cell clones were isolated from three adults with high degree of resistance to infection by @entity383 . The lymphokine secretion profiles of these clones were determined and compared to those of 21 CD3+, CD4+, CD8- clones with unknown specificity, established from these same subjects in the same cloning experiment. Almost all parasite-specific clones produced interleukin (IL)-4 and interferon (IFN)-gamma in large amounts. However, they generally produced more IL-4 than @entity379 ; variations in IL-4/ @entity379 ratios were accounted for by differences in @entity379 production since IL-4 levels were comparable for the clones from the three subjects. T cell clones of unknown specificity produced significantly less IL-4 and more @entity379 than parasite-specific T cell clones. Most clones produced IL-2, and IL-2 production did not differ between the two types of clones. Parasite-specific T cell clones from the resistant subjects were compared to specific T cell clones from a sensitized adult from a nonendemic area: T cell clones from this latter subject were the highest @entity379 and the lowest IL-4 producers, compared to those of resistant subjects. Thus, parasite-specific T cell clones isolated from adults resistant to @entity383 belong to the Th0 subset and produced more IL-4 than @entity379 (Th0/2), whereas clones of a sensitized adult from a nonendemic area are also Th0, but produce more @entity379 than IL-4 (Th0/1). These results support previous conclusions on the role of IgE in protection against schistosomes in @entity1 , and may indicate that @entity379 is required for full protection.
