Globose basal cells are required for reconstitution of olfactory epithelium after XXXX lesion.

@entity1 @entity4648 @entity5702 @entity35 @entity5495
Despite a remarkable regenerative capacity, recovery of the @entity1 olfactory epithelium can fail in severely injured areas, which subsequently reconstitute as aneuronal respiratory epithelium ( @entity4648 ). We contrasted the cellular response of areas of the @entity35 epithelium that recover as olfactory after @entity5495 lesion with those undergoing respiratory @entity4648 in order to identify stem cells that restore lesioned epithelium as olfactory. Ventral olfactory epithelium is at particular risk for @entity4648 after lesion and patches of it are rendered acellular by @entity5495 exposure. In contrast, @entity5702 ( @entity5702 , marked by staining with GBC-2) are preserved in surrounding ventral areas and uniformly throughout dorsal epithelium, which consistently and completely recovers as olfactory after lesion. Over the next few days, neurons reappear, but only in those areas in which @entity5702 are preserved and multiply. In contrast, parts of the epithelium in which @entity5702 are destroyed are repopulated in part by Bowman's gland cells, which pile up above the basal lamina. Electron microscopy confirms the reciprocity between gland cells and @entity5702 . By 14 days after lesion, the areas that are undergoing @entity4648 are repopulated by typical respiratory epithelial cells. As horizontal basal cells are eliminated from all parts of the ventral epithelium, the data suggest that GBC-2(+) cells are ultimately responsible for regenerating olfactory neuroepithelium. In contrast, GLA-13(+) cells may give rise to respiratory metaplastic epithelium where @entity5702 are eliminated. Thus, we support the idea that a subpopulation of @entity5702 is the neural stem cell of the olfactory epithelium.
