@entity1152 in the Northern Region XXXX Survey, 1985-1997: prenatal diagnosis and outcome.

@entity1 @entity154 @entity2007 @entity2978 @entity4501 @entity1152 @entity2209 @entity260 @entity354 @entity1282 @entity204
OBJECTIVE: This study was undertaken to determine the rate of prenatal diagnosis and surgical outcome of all cases of @entity1152 reported to the Northern Region @entity154 Survey. STUDY DESIGN: A retrospective review was conducted on maternal and @entity1 case notes of all cases of @entity1152 in the Northern Region from 1985-1997, inclusive. RESULTS: A total of 176 cases of @entity1152 was reported, and 158 diagnoses were confirmed after birth. Six cases were excluded because of incomplete data. Among the 32 @entity1 in whom @entity1152 was suspected antenatally because of an absent stomach bubble and hydramnios, 14 (44%) had @entity1152 confirmed postnatally. In 10 of the 18 @entity1 with false-positive diagnoses the stomach was subsequently seen. @entity1152 should have been suspected prenatally in a further 38 @entity1 with @entity2978 , 3 of whom also had an absent stomach bubble. There were 12 pregnancy terminations, 1 spontaneous abortion, and 19 perinatal @entity204 (including 9 @entity2209 ). Among the @entity1 with @entity1152 , 63.2% had associated anomalies (including 5.3% with @entity2007 ), and 78.4% of these anomalies were missed prenatally. Among the live births 21.5% of the @entity1 had a birth weight below the 5th percentile. One hundred eight (90%) had @entity1152 with a @entity4501 , and overall 102 (85%) underwent a primary repair. Among the 120 @entity1 who underwent surgical treatment 11 subsequently died, and 6 of these @entity204 were related to @entity260 . Thirty-nine @entity1 (32.5%) had postoperative @entity354 , necessitating fundoplication in 21 cases. At 2-year follow-up 23 of 89 @entity1 had @entity1282 , for which 7 still required a gastrostomy or jejunostomy. @entity1 in whom the condition was diagnosed prenatally were more likely to need prolonged mechanical ventilation, to have a longer hospital stay, and to have long-term gastrointestinal problems. CONCLUSIONS: Most cases of @entity1152 are not suspected prenatally. Among fetuses with ultrasonographic features suggestive of @entity1152 , 50% have the disorder confirmed postnatally. Overall perinatal and @entity1 mortality rate among those with @entity1152 is high (21.6%), and a further 21% of affected @entity1 have significant morbidity after the age of 2 years.
