The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic XXXX .

@entity281 @entity794
@entity794 is a major, highly clonal, pathogen causing @entity281 . This study aimed at investigating the diverse distribution of bacterial adhesins in most prevalent @entity794 types causing @entity281 . 200 @entity794 isolates, categorized into ribogroups by automated ribotyping, i.e. rDNA restriction fragment length polymorphism analysis, were screened for the presence of a panel of adhesins genes. Within the collection of isolates, automated ribotyping detected 98 distinct ribogroups. For many ribogroups, characteristic tandem genes arrangements could be identified. In the predominant @entity794 cluster, enlisting 27 isolates, the bbp gene encoding bone sialoprotein-binding protein appeared a typical virulence trait, found in 93% of the isolates. Conversely, the bbp gene was identified in just 10% of the remaining isolates of the collection. In this cluster, co-presence of bbp with the cna gene encoding collagen adhesin was a pattern consistently observed. These findings indicate a crucial role of both these adhesins, able to bind the most abundant bone proteins, in the pathogenesis of @entity281 , there where biomaterials interface bone tissues. This study suggests that specific adhesins may synergistically act in the onset of @entity281 and that anti-adhesin strategies should be targeted to adhesins conjointly present.
