Management of increased intraocular pressure after XXXX extraction.

@entity2134 @entity231 @entity6839
We measured the change in intraocular pressure prospectively after extracapsular @entity231 extraction in 80 eyes after treatment with either @entity2134 gel, @entity2134 4% solution, @entity6839 0.5% solution, or placebo. Intraocular pressure, pupil size, and anterior chamber cellular reaction were measured in a masked fashion on the first day after surgery. A significant increase in intraocular pressure was found in all groups postoperatively when compared with baseline values (P less than .001). Eyes treated with @entity2134 gel had an average intraocular pressure increase of 4.2 +/- 2.1 mm Hg (mean +/- 1 S.E.), eyes treated with @entity2134 4% eyedrops had an average increase of 9.8 +/- 2.8 mm Hg, and eyes treated with @entity6839 demonstrated an intraocular pressure increase of 8.25 +/- 3.19. The intraocular pressure in untreated eyes (controls) increased by an average of 12.9 +/- 2.7 mm Hg. Only the difference in intraocular pressure change between the eyes treated with @entity2134 gel and control eyes was statistically significant (P = .025). Postsurgical intraocular pressure exceeding 25 mm Hg was observed in three of 20 @entity2134 gel treated eyes (15%) and 11 of 20 control eyes (55%). @entity2134 treatment was not associated with noticeable changes in intraocular inflammatory response, nor were significant ocular or systemic adverse reactions observed. A single administration of @entity2134 gel is effective in reducing increased intraocular pressure for the first 24 hours after extracapsular @entity231 extraction.
