Results of adjuvant radiation therapy in XXXX . Thomas Jefferson University Hospital experience.

@entity1 @entity5 @entity3 @entity188
From 1972 to 1981, 174 @entity1 with @entity188 surgically staged as B2 or C disease, underwent surgical resection of the @entity5 for cure. Eighty-eight @entity1 received surgery only with no further adjuvant therapy, and the remaining 86 @entity1 were treated with a combination of radiation and surgery. Twenty-nine @entity1 received low-dose preoperative radiation (500 rad in one fraction); 26 @entity1 received postoperative radiation (4500 rad in 5 weeks); and 31 @entity1 received combined low-dose preoperative radiation (500 rad) and postoperative radiation (4500 rad in 5 weeks). This experience was analyzed to determine the patterns of failure and the impact of adjuvant therapy on survival. @entity1 undergoing surgery alone had a 26% incidence of local failure in the pelvis and a 57% incidence of distant @entity3 . @entity1 receiving low-dose preoperative radiation had a reduction in the rate of distant @entity3 (24%), but no effect on local failure (34%). On the other hand, @entity1 receiving postoperative radiation had a reduction in the local failure rate (11%), with no effect on distant @entity3 (50%). @entity1 who received the combined preoperative and postoperative treatment had a reduction in both the local recurrence rate (7%), and the rate of distant @entity3 (13%), and these @entity1 also had a substantial improvement in survival over surgery alone. Survival of @entity1 undergoing surgery alone was 34% at 5 years and was not substantially different for @entity1 undergoing low-dose preoperative irradiation (48%), or for @entity1 receiving postoperative irradiation (29%). Survival in @entity1 receiving combined preoperative and postoperative irradiation was substantially better (78%) than the other groups of @entity1 .
