[The clinical application of glycosylated hemoglobin A1c and glycated albumin values in cirrhosis XXXX with @entity4854 ].

@entity1 @entity2175 @entity417 @entity1575 @entity4854 @entity413
OBJECTIVE: To evaluate the diagnostic value of glycosylated hemoglobin A1c (HbA1c) and glycated albumin(GA) in @entity4854 @entity1 with @entity1575 ( @entity1575 ). METHODS: One @entity1575 @entity1 were divided into @entity417 and no- @entity417 group by Hb 110 g/L. The no- @entity417 group was further divided into low albumin (serum albumin <30 g/L), and high albumin group (serum albumin 30-<40 g/L). One @entity2175 without @entity1575 were included as control group (T2DM). HbA1c, GA, fasting plasma @entity413 (FPG), postprandial 2h plasma @entity413 (2hPG) were collected for statistical analysis. RESULTS: (1) The HbA1c level in @entity1575 with @entity417 tended lower than that in T2DM subjects [(6.76  2.20)% vs (7.34  1.23)%, P=0.06]; though the level of GA [(19.10  7.47)% vs (16.68  2.90)%, P<0.01] and 2hPG [(12.09  3.39) mmol/L vs (10.84  2.95) mmol/L, P<0.05] were significantly higher than that in T2DM group. (2) No- @entity417 subjects in @entity1575 group with albumin <30 g/L had obviously higher GA levels than those with albumin 30-<40 g/L and T2DM (albumin>= 40 g/L) [(18.79  2.28)% vs (16.71  2.42)% and (16.73  2.96)%, P<0.01]; though the level of HbA1c of three groups above has no significant difference. (3) The level of HbA1c between @entity1575 without @entity417 group and T2DM group had no significant difference (P>0.05); and the level of GA between @entity1575 without @entity417 group with albumin 30-<40 g/L and T2DM group had no significant difference (P>0.05). (4) The HbA1c has a positive correlation with FPG and 2hPG in @entity1575 (FPG:r=0.45, P<0.001; 2hPG:r=0.33, P=0.001) and T2DM subjects (FPG: r=0.76, P<0.001; 2hPG: r=0.81, P<0.001). GA also has a positive correlation with FPG and 2hPG in @entity1575 (FPG: r=0.48, P<0.001; 2hPG: r=0.39, P<0.001) and T2DM subjects (FPG: r=0.74, P<0.001; 2hPG: r=0.76, P<0.001). CONCLUSION: It is unfavorable to use HbA1c to evaluate the blood @entity413 level in @entity1575 @entity1 with Hb<110 g/L and to use GA in patients with serum albumin <30 g/L.
