Mortality and renal function decline among a community-based Chinese population with normal or mildly XXXX .

@entity1 @entity8 @entity1009 @entity740 @entity633 @entity204 @entity414
BACKGROUND: Longitudinal studies of the mortality and renal outcomes among the population with an estimated glomerular filtration rate (eGFR) >30 mL/ @entity1009 .73 m(2) and among the elderly are limited, especially in developing countries. METHODS: This prospective cohort study included 1563 residents aged 59.5    9.4 years from an urban district of Beijing, China. All @entity1 had an eGFR >30 mL/ @entity1009 .73 m(2). Urinary albumin-to-creatinine ratio and eGFR were assessed at baseline, and their relation with mortality and renal function decline after a 4-year follow-up were analyzed. RESULTS: During 4 years (6142 @entity1 -years) of follow-up, 59 @entity204 occurred (9.6 per 1000 @entity1 -years). After adjusting for potential confounders, @entity633 was associated with increased risk of mortality, with an odds ratio (OR) of 3.09 [95% confidence interval (CI) 1.53-6.26]. Altogether 183 @entity1 (12.3%) developed renal function decline, with a median change of eGFR of -20.0 mL/ @entity1009 .73 m(2). Presence of @entity633 was significantly associated renal function decline, with an OR of 1.79 (95% CI 1.02-3.15). Plasma @entity414 (OR = 1.25/59  mol/L increase, 95% CI 1.10-1.43) and age (OR = 1.35/5 years increase, 95% CI 1.22-1.50) was also independently associated with renal function decline. Baseline eGFR was not significantly associated with either mortality or renal function decline in our analysis. CONCLUSIONS: Compared with eGFR, @entity633 is a strong independent predictor for both mortality and renal function decline among a Chinese population with normal or mildly @entity8 . Furthermore, plasma @entity414 level and age are also independently associated with renal function decline and therefore may be used for identifying @entity1 at higher risk of @entity740 progression.
