Comparison of intracerebral transplantation effects of different stem cells on XXXX models.

@entity64 @entity1313 @entity19 @entity5 @entity35
UNASSIGNED: In the present study, induced pluripotent stem cells (iPSCs), induced neural stem cells (iNSCs), mesenchymal stem cells (MSCs) and an immortalized cell line (RMNE6), representing different characteristics of stem cells, were transplanted into normal and/or injured brain areas of @entity64 models, and their effects were compared to select suitable stem cells for cell replacement @entity64 therapy. The @entity35 and @entity19 ischaemic models were constructed using the middle cerebral artery occlusion technique. Both electrocoagulation of the artery and the intraluminal filament technique were used. The behaviour changes and fates of grafted stem cells were determined mainly by behaviour testing and immunocytochemistry. Following iPSC transplantation into the corpora striata of normal @entity19 , a @entity5 developed in the brain. The iNSCs survived well and migrated towards the injured area without differentiation. Although there was no tumourigenesis in the brain of normal or ischaemic @entity19 after the iNSCs were transplanted in the cortices, the behaviour in ischaemic @entity19 was not improved. Upon transplanting MSC and RMNE6 cells into ischaemic @entity35 brains, results similar to iNSCs in @entity19 were seen. However, transplantation of RMNE6 caused a @entity1313 . Thus, tumourigenesis and indeterminate improvement of behaviour are challenging problems encountered in stem cell therapy for @entity64 , and the intrinsic characteristics of stem cells should be remodelled before transplantation. Copyright    2015 John Wiley _ Sons, Ltd.
