Comparison of fibrovascular ingrowth into XXXX and porous @entity691 orbital implants.

@entity692 @entity32 @entity95 @entity691
Two porous orbital implants available for clinical use in the anophthalmic socket are @entity692 (HA) and porous @entity691 (PP). We examined the rate and the extent of fibrovascular ingrowth into these implants using histopathologic criteria in a @entity95 model. Thirty-two New Zealand white @entity95 underwent a unilateral enucleation with placement of a 14-mm spherical orbital implant. Twelve @entity95 received HA, 12 small-pore PP, and 8 large-pore PP. The implants inserted were wrapped either in autologous sclera with and without anterior fenestrations or as unwrapped spheres. The implants were harvested at 6 and 12 weeks. The extent of fibrovascular ingrowth was assessed by determining the percentage of the cross-sectional area penetrated by fibrovascular tissue. On gross inspection, 12 implants (37.5%) were found to be exposed at harvesting; however, only two were grossly infected. The highest rate of exposure was found among the unwrapped implants. Wrapped versus unwrapped and fenestrated versus unfenestrated implants did not result in significant differences in the extent of vascularization. @entity692 implants were vascularized most rapidly. The small-pore PP implants did not become fully vascularized during the study, and yet complete vascularization was found in the large-pore PP at 12 weeks. The most intense areas of microscopic fibrovascular ingrowth were in the region where the extraocular muscles were in direct contact with the implant and at the posterior opening. Exposure of the implant was accompanied by chronic and acute @entity32 . Both HA and large-pore PP spherical implants are capable of complete vascularization in this animal model.(ABSTRACT TRUNCATED AT 250 WORDS)
