XXXX Effects On Sensorimotor Gating and Mismatch Negativity in @entity1 with Chronic Psychosis.

@entity1 @entity308 @entity3391 @entity3393 @entity914 @entity3652 @entity5527 @entity161 @entity427
UNASSIGNED: @entity1 with chronic @entity914 (CPD) exhibit deficient sensorimotor gating (measured by prepulse inhibition (PPI) of @entity427 ) and @entity5527 ( @entity5527 ). In healthy subjects (HS), @entity3391 ( @entity3391 ) antagonists like @entity3393 and @entity3652 increase PPI, and under some conditions, @entity3393 enhances @entity5527 ; these findings present a challenge to understanding the basis for @entity5527 in @entity914 , as reduced @entity3391 activity is implicated in the pathogenesis of these disorders. Here we assessed for the first time the effects of @entity3393 on PPI and @entity5527 in CPD subjects. Baseline PPI was measured in HS and @entity1 with a diagnosis of @entity161 or @entity914 , @entity308 . Subjects (total n=84) were then tested twice, in a double-blind crossover design, comparing either: (1) placebo vs 10   mg of @entity3393 or (2) placebo vs 20   mg @entity3393 . Tests included measures of acoustic @entity427 magnitude and habituation, PPI, @entity5527 , autonomic indices, and subjective self-rating scales. @entity3393 (20   mg) significantly enhanced PPI in CPD subjects, and enhanced @entity5527 across subject groups. These effects on PPI were age dependent and most evident in older CPD @entity1 , whereas those on @entity5527 were most evident in younger subjects. The lower dose (10   mg) either had no detectable effect or tended to degrade these measures. The @entity3391 antagonist, @entity3393 , has dose-dependent effects on preconscious, automatic measures of sensorimotor gating and auditory sensory processing that are associated with enhanced cognition and function in CPD @entity1 . Ongoing studies will determine whether these @entity3393 -induced changes predict acute pro-cognitive or otherwise clinically beneficial effects in CPD @entity1 .Neuropsychopharmacology advance online publication, 1 July 2015; doi:10.1038/npp.2015.162.
