Study of behavioural and neural bases of XXXX with an fMRI paradigm based on an n-back task.

@entity1 @entity1545 @entity227 @entity73 @entity2414 @entity2849
UNASSIGNED: The goal of this study was to propose a new functional magnetic resonance imaging (fMRI) paradigm using a language-free adaptation of a 2-back working memory task to avoid cultural and educational bias. We additionally provide an index of the validity of the proposed paradigm and test whether the experimental task discriminates the behavioural performances of healthy @entity1 from those of individuals with working @entity2414 . Ten healthy @entity1 and nine @entity1 presenting working @entity2414 due to @entity1545 ( @entity1545 ) performed the developed task. To inspect whether the paradigm activates brain areas typically involved in @entity227 ( @entity227 ), brain activation of the healthy @entity1 was assessed with fMRIs. To examine the task's capacity to discriminate behavioural data, performances of the healthy @entity1 in the task were compared with those of @entity1545 @entity1 . Data were analysed with GLM-based random effects procedures and t-tests. We found an increase of the BOLD signal in the specialized areas of @entity227 . Concerning behavioural performances, healthy @entity1 showed the predicted pattern of more hits, less omissions and a tendency for fewer @entity2849 , more self-corrected responses, and faster reaction times, when compared with subjects presenting @entity73 . The results suggest that this task activates brain areas involved in @entity227 and discriminates behavioural performances of clinical and non-clinical groups. It can thus be used as a research methodology for behavioural and neuroimaging studies of @entity227 in block-design paradigms.
