Impact of renin-angiotensin system blockade on clinical outcome in XXXX .

@entity1 @entity101 @entity5 @entity2904 @entity2178 @entity11 @entity2903 @entity463 @entity1349
BACKGROUND AND PURPOSE: Despite surgery, radiotherapy (RT) and @entity2903 ( @entity2904 ), the prognosis of @entity463 ( @entity463 ) @entity1 remains dismal. Normally prescribed with the aim to lower blood pressure, @entity2178 ( @entity2178 ) inhibitors were reported to reduce angiogenesis and @entity5 growth in @entity5 models including one @entity11 . Thus whether treatment with @entity2178 inhibitors could be associated with a better clinical outcome in @entity463 @entity1 was investigated. METHODS: A series of 81 consecutive @entity1 , homogeneously treated with RT and @entity2904 for a newly diagnosed, supratentorial @entity463 , were analysed. The objective of this retrospective study was to assess the impact of angiotensin-converting enzyme inhibitors (ACEIs) and @entity2178 receptor 1 blockers (ARBs) on functional independence, progression-free survival (PFS) and @entity1349 ( @entity1349 ). RESULTS: Amongst the 81 @entity463 @entity1 analysed, 26 were already treated for @entity101 (seven with ACEIs and 19 with ARBs). The number of @entity1 who remained functionally independent at 6  months after RT was higher in the group of @entity1 treated with @entity2178 inhibitors compared to the other @entity1 (85% vs. 56%, P  =  0.01). In @entity1 treated with @entity2178 inhibitors, PFS was 8.7  months (vs. 7.2  months in the other @entity1 ) and @entity1349 was 16.7  months (vs. 12.9  months). The use of @entity2178 inhibitors was a significant prognostic factor for both PFS (P  =  0.04) and @entity1349 (P  =  0.04) in multivariate analysis. CONCLUSION: Treatment with @entity2178 inhibitors in combination with RT and @entity2904 might improve clinical outcome in GBMs. Prospective trials are needed to test this hypothesis.
