XXXX : a study of four kindreds.

@entity1 @entity459 @entity656 @entity2745 @entity74 @entity460 @entity1011 @entity652 @entity461
Four kindreds with hereditary hypercalcaemia have been investigated. Thirty-seven of 72 subjects examined had hypercalcaemia with an autosomal dominant pattern of inheritance. Hypercalcaemic @entity1 had total serum @entity460 of 2.91 +/- 0.12 mmol l-1. Serum @entity461 ( @entity461 ) was normal while daily urinary @entity460 excretion was subnormal (below 2.5 mmol) in 45%. Comparison with an age-matched group of @entity1 with @entity459 gave a small overlap regarding serum human @entity461 , urinary @entity460 and the ratio between @entity460 clearance and @entity1011 clearance. Family screening therefore is of diagnostic importance. Twelve subjects had been subjected to parathyroid surgery before the correct diagnosis was settled, none of the cases had an @entity652 . Three @entity1 became normocalcaemic and the others had persistent hypercalcaemia. One male non-abuser had seven episodes of @entity656 before surgery and none after. The findings in all four kindreds are compatible with @entity2745 ( @entity2745 ). This @entity74 of unknown aetiology, therefore, also exists in Scandinavia. It is of importance to consider @entity2745 in the differential diagnosis of hypercalcaemia, since this disorder usually has a benign prognosis if untreated.
