Targeting neutrophils in XXXX : translational insights from experimental studies.

@entity1545 @entity1 @entity64 @entity2657 @entity731 @entity63 @entity26 @entity397 @entity715 @entity385
Neutrophils have key roles in @entity63 @entity1545 , @entity715 , and @entity731 . As such, neutrophils are of great interest as targets to treat and prevent @entity385 . After @entity64 , neutrophils respond rapidly promoting blood-brain barrier disruption, @entity2657 , and @entity1545 . A surge of neutrophil-derived reactive @entity26 species, proteases, and cytokines are released as neutrophils interact with cerebral endothelium. Neutrophils also are linked to the major processes that cause @entity385 , @entity715 , and @entity731 . @entity715 is promoted through interactions with platelets, clotting factors, and release of prothrombotic molecules. In @entity731 , neutrophils promote plaque formation and @entity397 by generating oxidized-low density lipoprotein, enhancing monocyte infiltration, and degrading the fibrous cap. In experimental studies targeting neutrophils can improve @entity64 . However, early @entity1 studies have been met with challenges, and suggest that selective targeting of neutrophils may be required. Several properties of neutrophil are beneficial and thus may important to preserve in @entity1 with @entity64 including antimicrobial, antiinflammatory, and neuroprotective functions.
