Aggravation of electrically provoked XXXX during treatment with @entity2779 .

@entity1 @entity137 @entity1165 @entity3303 @entity2224 @entity67 @entity943 @entity2779
@entity2779 is a new class Ic antiarrhythmic agent currently being investigated in the United States. It is generally well tolerated. We administered @entity2779 to 16 @entity1 with @entity1165 ( @entity1165 ) that had been refractory to conventional antiarrhythmic drug therapy. Three of these 16 @entity1 developed electrically provoked incessant @entity1165 during treatment with @entity2779 without other evidence of @entity137 . These @entity943 subsided after @entity3303 was administered. @entity2779 therapy was discontinued in each case. Incessant @entity1165 did not develop in any of these @entity1 in the absence of antiarrhythmic drugs or on antiarrhythmic drugs other than @entity2779 . Alternative effective treatment was identified for each @entity1 . Although @entity1165 was initially provoked by pacing in each of these @entity1 , these observations suggest that @entity2779 , like some other class Ic drugs, may favor the development of incessant @entity1165 in occasional @entity1 . This appears most likely to occur in @entity1 with @entity67 and prior sustained @entity1165 or @entity2224 .
