Effects of a high protein diet on cognition and brain metabolism in cirrhotic XXXX .

@entity1 @entity7008 @entity2796 @entity82 @entity101 @entity409 @entity148 @entity1251 @entity35 @entity2414 @entity99
UNASSIGNED: @entity99 ( @entity99 ) is a neurological complication observed in @entity1 with @entity409 . @entity1 who suffer from @entity99 present neuropsychiatric, neuromuscular and behavioral symptoms. Animal models proposed to study @entity99 resulting from @entity82 mimic the clinical characteristics of @entity82 and @entity101 , and require the administration of hepatotoxins such as @entity7008 ( @entity2796 ). The aim of this study was to assess the effects of a high protein diet on motor function, @entity148 and memory processes in a model of @entity82 induced by @entity2796 administration. In addition, we used cytochrome c-oxidase (COx) histochemistry to assess the metabolic activity of the limbic system regions. Male @entity35 were distributed into groups: control, animals with @entity82 , Control @entity35 receiving a high protein diet, and animals with @entity82 receiving a high protein diet. Results showed preserved motor function and normal @entity148 levels in all the groups. The animals with @entity82 showed an impairment in active avoidance behavior and spatial memory, regardless of the diet they received. However, the animals with @entity82 and a high protein diet showed longer escape latencies on the spatial memory task. The model of @entity82 presented an under-activation of the dentate gyrus and @entity1251 hippocampal subfields and the medial part of the medial mammillary nucleus. The results suggest that a high protein intake worsens spatial @entity2414 shown by the @entity2796 -induced model of @entity82 . However, high protein ingestion has no influence on the COx hypoactivity associated with the model.
