Are gains of chromosomal regions 7q and 11p important abnormalities in XXXX ?

@entity5 @entity1 @entity4180 @entity521
@entity521 exhibiting deletion of a segment of the long arm of chromosome 11 represents a genetic subtype of @entity5 that is distinct from those exhibiting @entity4180 amplification or 1p deletion. The 11q- genetic subtype is further characterized by gain of 17q and loss of distal 3p material. Gain of 11p material has also been reported in @entity521 with 11q loss, but at a considerably lower frequency than gain of 17q or loss of the distal 3p region. Our results, however, indicate that gain of 11p may occur more frequently in 11q- @entity521 than what was previously realized. Comparative genomic hybridization analyses of @entity521 tissue from eleven @entity1 indicated that six of 11 @entity5 (55%) with loss of 11q also possessed gain of 11p. The shortest region of 11p gain was 11p11.2-->p14. G-banding and fluorescence in situ hybridization analysis performed on @entity5 cells from primary and metastatic sites from one @entity1 allowed us to infer that gain of 11p arose secondarily to the abnormality that led to the loss of 11q material. Gain of an entire chromosome 7 was detected in 17 of 43 (40%) @entity5 , whereas gain of 7q was detected in 5 of 43 (12%) @entity5 . Unlike gain of 11p, gain of an entire chromosome 7 appears to be prevalent in all @entity5 stages and is not limited to the 11q- @entity5 subtype. Gain of 7q, however, is more prevalent in higher stage @entity5 . G-band cytogenetic analysis indicated that an unbalanced t(3;7) was responsible for the gain of 7q and loss of 3p material in one case. We discuss the possibility that gain of 7/7q, and 11p material may contribute to either tumorigenesis or progression.
