Air particulate matter exacerbates lung response on Sj  XXXX animals.

@entity1 @entity66 @entity19 @entity358 @entity244 @entity224 @entity792
Epidemiological studies have associated air particulate matter (PM) inhalation with a decline in lung function and increased morbo-mortality due to @entity66 , particularly in susceptible populations. Sj  @entity244 ( @entity244 ) is a chronic @entity792 characterized by cellular infiltration in exocrine glands and extraglandular tissue, being the respiratory tract an important target. We evaluated the effect of PM on the airways of NOD @entity19 , which develop @entity244 and BALB/c @entity19 . BALB/c or NOD @entity19 (2-3 months) were randomized in two groups and exposed to intranasal instillation either with saline (control) or ROFA solution (1mg/kg body weight). After 24h, @entity19 were euthanized in order to perform lung histology, or measure total cell number (TCN), differential cell count (DCC) and @entity224 anion generation in the bronchoalveolar lavage (BAL) fluid. BALB/c @entity19 showed normal histoarchitecture, while NOD @entity19 showed lymphocytic peribronchial infiltrates. ROFA exposure affected the respiratory tract from both BALB/c and NOD @entity19 , with a significant increase in the TCN (p<0.05) and generation of O2(-) (p<0.05), as well as an imbalance in the DCC (p<0.05). All histological observations correlated with the cellular parameters evaluated. Lesions in NOD @entity19 were more severe than those of BALB/c, showing cellular infiltration in the alveoli and leading to a greater decrease in the alveolar space. We have proved that in this experimental Sj  @entity244 animal model (NOD @entity19 ); airborne pollution exacerbates pre-existing @entity358 . These findings show experimental evidence on the harmful effects of airborne pollution on the airways of @entity1 with Sj  @entity244 .
