Defining molecular phenotypes of XXXX -associated @entity957 : validation of three-class hypothesis.

@entity1 @entity986 @entity5 @entity470 @entity957 @entity7 @entity3546 @entity982 @entity1799 @entity1082
OBJECTIVE: The purpose of this study was to determine if @entity957 ( @entity957 ) classified into three groups based on @entity1082 ) 16 DNA presence and @entity986 expression display different protein expression patterns. STUDY DESIGN: Cross-sectional study. SETTING: A laboratory-based study of @entity1 with @entity957 treated at a tertiary care academic medical center. SUBJECTS AND METHODS: @entity982 -embedded @entity957 specimens from 77 @entity1 classified into the three-class model (HPV negative, HPV inactive [ @entity1799 +/ @entity986 -], and HPV active [ @entity1799 +/ @entity986 +]) were queried for the expression of 14 @entity5 progression proteins using AQUA (HistoRx, New Haven CT). Protein expression between groups was assessed by analysis of variance. Global expression patterns were determined by unsupervised hierarchical clustering. RESULTS: There were significant differences in expression of @entity3546 (P = 0.009), @entity470 (P = 0.009), and @entity7 (P = 0.028) between groups. @entity5 had overexpression of @entity3546 . Hierarchical clustering showed HPV-negative and HPV-inactive @entity5 displayed association patterns distinct from @entity5 . CONCLUSIONS: Tumors classified by HPV DNA presence and @entity986 expression have different molecular phenotypes. This is the first demonstration of overexpression of @entity3546 (also found in HPV-caused cervical @entity5 ) in HPV-active @entity957 . HPV-active @entity957 may share a similar ontogeny to HPV-caused cervical @entity5 .
