Selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in normal pressure XXXX .

@entity32 @entity650 @entity322 @entity14210 @entity1276 @entity1356 @entity303 @entity73 @entity16 @entity13236 @entity6889 @entity22597 @entity310 @entity15787 @entity4155 @entity179 @entity4654 @entity3646 @entity688 @entity4452
OBJECTIVES: Normal pressure @entity1276 (NPH) is a treatable @entity16 developing in the elderly. It is characterized by @entity73 , @entity322 and @entity303 development caused by disorders in the cerebrospinal fluid (CSF) circulation. The diagnosis can be easily mistaken for other @entity179 , which are often accompanied by @entity32 and the production of cytokines. The aim of our study was to determine and compare selected CSF and plasma cytokines with respect to their informative value for laboratory diagnostics of NPH. METHODS: The levels of @entity1356 , @entity3646 , @entity650 , @entity688 , @entity4155 , @entity4654 , @entity15787 , @entity13236 , @entity4452 , @entity14210 , @entity22597 , @entity6889 , INF-y, sCD40L and @entity310 were measured in the CSF and plasma in age-matched subjects with NPH (n=20) and controls (n=20) by multiplex assay. RESULTS: CSF @entity1356 , @entity650 and @entity688 were significantly increased on the 1st day of lumbar drainage in NPH (p<0.01). No significant changes were observed in the plasma. The CSF cytokines were one to three orders of magnitude higher compared to the plasma. CONCLUSION: CSF can better show the neurodegenerative changes in the brain. The cytokines @entity1356 , @entity650 and @entity688 may be helpful in NPH diagnostics.
