A case-control study of risk factors for XXXX in adults, Denmark, 2005-2009.

@entity1 @entity16119 @entity344 @entity281 @entity6425
UNASSIGNED: Rotavirus (RV) infections affect young @entity1 , but can also occur in adults. We sought to identify risk factors for @entity6425 in adults aged    18 years in Denmark, and to describe illness and genotyping characteristics. From March 2005 to February 2009, we recruited consecutive cases of laboratory-confirmed RV @entity281 and compared them with healthy controls matched by age, gender and municipality of residence. We collected information on illness characteristics and exposures using postal questionnaires. We calculated univariable and multivariable matched odds ratios ( @entity16119 ) with conditional logistic regression. The study comprised 65 cases and 246 controls. Illness exceeded 10 days in 31% of cases; 22% were hospitalized. Cases were more likely than controls to suffer serious underlying health conditions [ @entity16119 5  6, 95% confidence interval (CI) 1  7-18], and to report having had close contact with @entity1 with @entity344 ( @entity16119 9  4, 95% CI 3  6-24), in particular young @entity1 aged 18 years. Close contact with young @entity1 @entity16119 adults with @entity344 is the main risk factor for RV @entity281 in adults in Denmark. RV vaccination assessments should consider that RV vaccination in @entity1 may indirectly reduce the burden of disease in adults.
