A randomised controlled clinical trial on the safety of co-administration of XXXX , @entity3070 and @entity2039 in infected schoolchildren in Uganda.

@entity3753 @entity3070 @entity1 @entity137 @entity66 @entity3754 @entity281 @entity380 @entity2040 @entity2039
Integrated chemotherapy of neglected @entity66 (NTD) through mass drug administration given as a single dose would increase treatment coverage and cost-effectiveness. This study reports on the safety of a combination of @entity3753 , @entity3070 and @entity2039 in the treatment of @entity3754 ( @entity3754 ), @entity2040 and soil-transmitted helminthiasis (STH) in infected @entity1 . In this randomised, controlled, single-blinded clinical trial conducted in 235 primary school @entity1 aged 5-18 years in Yumbe District in Northern Uganda, the triple combination therapy was compared with the current NTD programme regimen. Liver function testing was performed for all @entity1 who received combined therapy. The study included 48 @entity1 with @entity3754 alone, 60 @entity1 with @entity2040 ( @entity380 ), 41 @entity1 with STH, 49 @entity1 with @entity2040 + @entity3754 and 37 @entity1 with all three types of @entity281 . @entity1 were closely monitored by a paediatrician for any adverse reactions for 7 days. No serious adverse events were experienced. However, 4 of 18 @entity1 in the test group and 2 of 3 @entity1 in the control group who did not report any ill conditions before treatment developed @entity137 . The combined and conventional therapies were found to be equally safe. The efficacies of both therapies were comparable and satisfactory. [ClinicalTrials.gov identifier: NCT01050517].
