XXXX as a model to study the response to stimulation of the inflammation system.

@entity22073 @entity2002 @entity650 @entity1851
BACKGROUND: High basal plasma levels of inflammatory molecules are associated with a higher risk of cardiovascular events. It has been suggested that also the dynamic response to an inflammatory trigger is important in determining cardiovascular risk. The aim of the present study was to evaluate the use of vaccination against @entity22073 as an in vivo model to study the interindividual variation in the response to inflammatory triggers. METHODS: Ten healthy volunteers were vaccinated with 17D @entity22073 vaccine. Blood samples were drawn each day, until Day 8 after vaccination. Automated blood cell counting was performed, and the plasma concentrations of @entity1851 ( @entity1851 ), @entity650 ( @entity650 ) and @entity2002 were determined. RESULTS: In most individuals, @entity1851 levels peaked slightly (45% increase from basal values) around Day 7 after vaccination, preceded by an @entity650 (30%) peak around Day 5. @entity2002 levels showed a significant increase (10%) from Day 2 after vaccination, with a further rise (17%) around Day 5. The monocyte fraction showed a significant 2-fold increase on Day 7 after vaccination. The lymphocyte fraction increased slightly towards Day 7 (not significant). CONCLUSION: Our findings show that @entity22073 can be used as a model to study the response to mild stimulation of the inflammatory system.
