Proliferative activity of @entity19 mammary epithelium as affected by dietary fat and XXXX .

@entity19 @entity4336 @entity665 @entity460 @entity3812
Dietary fat and @entity460 have been found to affect significantly the proliferative status of the mammary glands. Female @entity19 (3-week-old C57BL/6J) were given either a low or high @entity4336 oil diet (3 or 30% by weight). One, 2, or 4 weeks after the dietary intervention the animals were given injections of @entity665 and/or @entity3812 ; 2 h later their thoracic mammary glands were removed and processed for histology and autoradiography. Animals on the high @entity4336 oil diet had an increased labeling index of both terminal ducts and mature ducts compared to the control group at each time (i.e., 10.1 +/- 2.1 versus 4.8 +/- 0.9% at 2 weeks). This effect of a high @entity4336 oil diet was evident on the mammary glands of animals at various ages. Animals on a high beef tallow diet also had a high labeling index. This effect of a high fat diet appeared to be reduced by dietary @entity460 . The labeling index for terminal ducts of animals on high @entity4336 oil diet decreased from 14.1 +/- 3.8, 11.9 +/- 3.4 to 8.5 +/- 1.8 and high beef tallow from 13.6 +/- 3.6, 11.4 +/- 0.7 to 9.5 +/- 1.3 for @entity460 levels of 0.1, 0.5, and 1.0%, respectively. Mitotic indices followed the same trend. These studies demonstrate that a high fat diet affects the proliferative status in the @entity19 mammary glands in a short period of time and that this effect can be reduced by dietary @entity460 .
