Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on XXXX -induced intestinal @entity105 .

@entity5 @entity2985 @entity1373 @entity4056 @entity105 @entity35 @entity694
@entity1373 after extensive loss of functioning small or large intestine might predispose to the development of @entity5 in the residual adapted bowel. To test this hypothesis, male Fischer @entity35 were randomized to receive 85 to 90% jejunoileal resection or bypass, subtotal colectomy, or no operation (controls). One week later, the first of six weekly s.c. injections of @entity2985 (15 mg/kg/week) was given. At the 36th week postoperatively, mean body weight after enterectomy or colectomy it was 78 to 79% of control. Adaptation after all three operations was characterized by 22 to 84% increments in villous height and crypt depth in the residual functioning ileum (p = 0.05 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity35 developed @entity4056 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity35 developed @entity4056 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001). Compared with controls, bypass reduced the number of @entity694 by 77% (p less than 0.001). Although resection did not affect @entity694 yield, it tripled the incidence of @entity5 in the duodenum and jejunum (p = 0.025). Colectomy promoted @entity105 (p less than 0.05). @entity5 were commoner after intestinal resection. the lower frequency of @entity5 after jejunoileal bypass contrasts with enhanced @entity105 after enterectomy or colectomy. Profound reduction in body weight may prevent the promotional effect of @entity1373 .
