Associations of mood symptoms with ante- and postnatal weight change in obese pregnancy are not mediated by XXXX .

@entity1 @entity308 @entity28 @entity4053 @entity148 @entity701
BACKGROUND: Both maternal @entity28 and disordered mood have adverse effects on pregnancy outcome. We hypothesized that maternal very severe @entity28 (SO) is associated with @entity308 (A_D) symptoms during pregnancy, with adverse effects on gestational weight gain (GWG), postpartum mood and postpartum weight retention (PPWR) and explored any mediation by circulating glucocorticoids. METHOD: We measured A_D symptoms with validated questionnaires at weeks 17 and 28 of pregnancy and 3 months postpartum in 135 lean [body mass index (BMI)    25 kg/m2] and 222 SO (BMI    40 kg/m2) pregnant women. @entity4053 serum @entity701 was measured by radioimmunoassay; GWG and PPWR were recorded. RESULTS: A_D symptoms were higher in the SO group during pregnancy and postpartum despite adjusting for multiple confounders including previous mental health diagnosis (p < 0.05), and were non-linearly correlated with total GWG ( @entity148 R 2 = 0.06, p = 0.037; @entity308 R 2 = 0.09, p = 0.001). In the SO group only, increased maternal @entity148 (b = 0.33, p = 0.03) and @entity308 (b = 0.19, p = 0.04) symptoms at week 17 of pregnancy were associated with increased PPWR, independent of total GWG and breastfeeding. @entity148 symptoms at week 28 of pregnancy, but not @entity308 , were non-linearly correlated with serum @entity701 level at week 36 of pregnancy (R 2 = 0.06, p = 0.02). @entity701 did not mediate the link between A_D symptoms and GWG. CONCLUSIONS: Maternal SO was associated with increased A_D symptoms, and with adverse effects on GWG and PPWR independent of circulating glucocorticoids. Strategies to optimize GWG and postpartum weight management in SO @entity1 should include assessment and management of maternal mood in early pregnancy.
