@entity12188 ( @entity12188 ) with the hematologic phenotype of severe XXXX .

@entity1 @entity417 @entity882 @entity12188 @entity381 @entity8674 @entity221 @entity491
A 3-year-old Filipino-American @entity1 with recurrent @entity221 , @entity381 , @entity417 , and @entity882 , was found to have a hemoglobin F level of 76.9%. His reticulocyte count was elevated (4.3%), and erythroblasts were present in his peripheral blood. The @entity1 's erythrocytes were microcytic (MCV 66.9 fl) but his serum ferritin level was normal. His bone marrow at initial presentation demonstrated normal cellularity without an increase in blast cells. The disease progressed with worsening @entity417 , @entity491 , and @entity882 , with increased blasts in his marrow and the appearance of a mediastinal mass. His liver, spleen, and lymph nodes were found to be infiltrated with myeloblasts, supporting a diagnosis of @entity12188 ( @entity12188 ). Analysis of the @entity1 's Hb F showed a Ggamma/Agamma ratio of 2.2, which was within the characteristic range for @entity12188 . A globin synthesis study using blood reticulocytes showed an alpha/non-alpha globin synthesis ratio of 2.24, typical of severe homozygous @entity8674 . Southern blot analysis of blood-leukocyte DNA from the @entity1 and his parents demonstrated no apparent abnormality in the beta-globin gene promoter or coding regions. The elevated level of Hb F in this @entity1 with @entity12188 appeared to be part of an acquired @entity8674 -like hematologic phenotype.
