Allometric model improves scaling of left atrial size in XXXX population: the use of body weight containing variables is challenged.

@entity18301 @entity28 @entity2121
BACKGROUND: Scaling left atrial (LA) size remains a challenge. An allometric model using body weight (BW) as scaling variable was recently proposed. We sought to examine the performance of this model in an @entity28 population. METHODS: A total of 266 consecutive overweight (110) and @entity28 subjects (class I, II, and III @entity28 81, 47, and 28, respectively) were studied; 46 normal subjects with normal body mass index (BMI) served as controls. @entity18301 ( @entity18301 ) was scaled to BW, body surface area (BSA), BMI and height, respectively, using both isometric and allometric models. RESULTS: There were no significant differences in age, gender, or height among the five groups. The prevalence of comorbid conditions, wall thickness, E/E' and @entity18301 measures increased significantly with increasing weight group (P < 0.01-0.001). With the isometric model, @entity18301 corrected by BW, BSA, and BMI significantly but @entity2121 decreased across the groups (P < 0.05-0.001). With the allometric model, @entity18301 overcorrection by BM, BSA, and BMI was improved, but remained in the class III @entity28 group. In contrast, scaling @entity18301 to height showed significant and graded increase across the five groups in accordance with the increases of BMI, E/E' and the prevalence of comorbid conditions. CONCLUSION: All isometric models that correct @entity18301 by BW or BW containing variables underestimate LA size in overweight and @entity28 groups. The allometric model using height provides more consistent results and should be preferred to models using BW or BW containing variables in scaling @entity18301 in @entity28 population.
