[Change in the therapeutic strategy when faced with an inadequate response to the pharmacological treatment of XXXX ].

@entity1 @entity71
INTRODUCTION. @entity71 ( @entity71 ) is a disorder of a biological origin affecting the neurodevelopment of the brain. It is estimated that 3-7% of school-age @entity1 present @entity71 . The most commonly used pharmacological treatments are amphetamines and methylphenidate (MPH). Although response rates to MPH are high, full remission rates reach only 56%. The 25% of @entity1 who do not respond to MPH would show a response to other stimulants and vice-versa. AIMS. To clinically evaluate @entity1 by detecting inadequate responses and the efficacy of a change to lisdexamfetamine dimesylate (LDX). @entity1 AND METHODS. The study was prospective and observation-based. Inadequate responses were considered to be those that presented non-coverage or no effect. The @entity71 Rating Scale IV ( @entity71 -RS-IV) and Clinical Global Impression-Severity (CGI-S) assessment scales were used for the clinical assessment, together with the Weiss Functional Impairment Rating Scale (WFIRS) and the @entity1 Health and Illness Profile (CHIP-AE). Data regarding adverse side effects were also collected. RESULTS. Forty-one @entity1 met criteria for inadequate response to treatment: 13.6    3.4 years, 54.6    13.2 kg, 158.5    17.2 cm and body mass index of 20.9    3.5 kg/m2. Reasons for change (non-exclusive): non-coverage (76%), lack of intensity of effect (68%) and presence of adverse side effects with the previous medication (16%). The mean score both at baseline and at nine months, on the @entity71 -RS, was 24.54    6.3 versus 12.01    3.2 (p < 0.01), respectively, and for the CGI-S values were 5.09    0.5 versus 2.91    0.8 (p < 0.01), respectively. The safety profile coincided with that of other stimulant-based treatments for @entity71 . CONCLUSIONS. When the response to MPH presents non-coverage or lack of effect, changing to LDX has proved to be effective, with an improvement in 86.7% of cases, which is similar to that of other studies. It is therefore a good therapeutic option in these @entity1 .
