Aromatase expression in low-grade XXXX : an immunohistochemical study.

@entity1204 @entity5 @entity1870 @entity6019 @entity1442 @entity46 @entity982
Aromatase expression has been described in stromal cells of @entity46 , @entity1870 and @entity1204 . We analyzed aromatase expression in a series of 23 low-grade @entity6019 . Archival formalin-fixed and @entity982 -embedded material was analyzed with immunohistochemistry. Aromatase expression was evaluated with a monoclonal and a polyclonal antibody using the peroxidase-antiperoxidase method. A score was calculated based on the percentage of positive @entity5 cells and the staining intensity. Aromatase was seen in 19 (83%) of 23 @entity5 with monoclonal antibody and 20 (87%) of 23 @entity5 with polyclonal antibody. Aromatase expression using the monoclonal antibody was scored as high in five (22%), moderate in nine (39%) and low in five (22%) @entity5 . Four (17%) low-grade @entity6019 did not stain for aromatase. Aromatase expression with the polyclonal antibody was scored as high in seven (31%), moderate in four (17%) and low in nine (39%) @entity5 . Three (13%) low-grade @entity6019 did not stain for aromatase. Little or no aromatase expression tended to correlate with stage I disease, while higher scores were more frequently associated with @entity1442 . Our results demonstrate that most low-grade @entity6019 express aromatase. The staining pattern, however, is heterogeneous. The high percentage of aromatase positivity in low-grade @entity6019 may have implications in the management of these @entity5 and offer new treatment modalities such as hormonal therapy with aromatase inhibitors.
