A novel orthotopic @entity19 model of XXXX with molecular imaging.

@entity5 @entity135 @entity1 @entity19
OBJECTIVES/HYPOTHESIS: Our goal was to develop a noninvasive, dynamic imaging method that would further the understanding of @entity135 ( @entity135 ) @entity5 growth and local spreading. We developed a novel orthotopic @entity19 model of @entity135 with a stable cell line expressing a red fluorescent protein gene to compare a molecular imaging @entity5 quantification with traditional caliper measurement. METHODS: An @entity135 -tdT stable cell line expressing the tdTomato gene was established, which were injected into the floor of the mouth of @entity19 . @entity5 growth was constantly monitored using molecular imaging for up to 35 days. The @entity5 were further evaluated by histologic examination. RESULTS: Established @entity5 consistently expressed fluorescent signals that were successfully imaged by molecular imaging during the study. Initial @entity5 development was detected earlier than caliper measurement would allow. The fluorescent signal quantities of @entity5 detected by the imaging correlated with the @entity5 sizes measured by calipers. CONCLUSIONS: This novel animal model represents an orthotopic @entity1 @entity135 model. The @entity5 can be detected earlier with molecular imaging than by conventional external caliper measurement. Unlike surgical measurement, the @entity5 can be quantified without disturbing the @entity5 environment. This model has significant potential for @entity135 oncologic research.
