Surgically treated incidentally discovered low-grade @entity11 are mostly XXXX mutated and 1p19q co-deleted with favorable prognosis.

@entity1 @entity1296 @entity5 @entity406 @entity11 @entity818 @entity816 @entity14051 @entity10 @entity130 @entity3271
OBJECTIVE: LGGs (low-grade @entity11 ) are sometimes encountered by chance during radiological examinations. These incidentally discovered LGGs (IDLGGs) were relatively under-studied in the literature. The purpose of current study is to review a cohort of @entity1 with IDLGGs surgically treated in our institution for their clinical and histological aspects and determine their @entity818 and 1p19q status. METHODS: All @entity1 with hemispheric LGGs receiving operation in our institution between 2001 and 2004 were reviewed. Clinical, radiological and treatment data of the @entity1 were collected and IDLGGs were retrieved and compared with symptomatic LGGs. Histological review was carried out and @entity406 -fixed paraffin embedded (FFPE) tissues of IDLGGs were examined for @entity818 / @entity14051 mutation and 1p/19q codeletion. RESULTS: Twenty three IDLGGs (10.4%) were identified while 196 @entity1 had symptomatic LGGs. The reasons for @entity1 with IDLGGs having radiological examination included @entity130 (47.8%), @entity1296 (26.1%), unrelated @entity10 (21.7%), and health checkup (4.4%). Clinically, @entity1 with IDLGGs had higher preoperative KPS (P < 0.001), smaller @entity5 volume (P = 0.014), lower frequency of eloquent areas involvement (P < 0.001) and higher rate of complete resection (P = 0.037) comparing to those with symptomatic LGGs. Histologically, there is a preponderance of @entity3271 and 11 oligoastrocytomas but there were also 6 @entity816 . @entity818 mutation and 1p/19q co-deletion were detected in 95.7% (22/23) and 69.6% (16/23) of IDLGGs, respectively. The latter encompassed all but one of the cases of @entity5 . @entity1 with IDLGGs had longer overall survival than those with symptomatic LGGs (P = 0.027). CONCLUSIONS: We conclude that the majority of IDLGGs are @entity818 mutated and are predominantly @entity5 . With a median follow-up of 9.3 years to our series, we conclude that @entity1 with IDLGGs had better prognosis than those with symptomatic LGGs. The favorable prognosis of IDLGGs may be accounted by the higher practicability of extensive resection, non-eloquent @entity5 location and smaller @entity5 volume. Frequent @entity818 mutation and 1p/19q co-deletion in IDLGGs may also contribute to the favorable prognosis of this subgroup of @entity1 .
