[Biochemical recurrence after curative treatment for XXXX : Performance of choline PET/CT in the assessment of local recurrence].

@entity1 @entity263 @entity9242
OBJECTIVE: To establish 18  @entity9242 -positron emission tomography/computed tomography (F-PET/CT) performances for the detection of local recurrence in a population of @entity1 with biochemical failure after primary curative treatment for @entity263 . MATERIAL AND METHOD: From February 2011  to February 2014, 55  @entity1 underwent a F-PET/CT for biochemical relapse after primary radical therapy for @entity263 localized or locally advanced. Primary therapies for @entity263 were 19  radical prostatectomy, 18  radiotherapy, 13  radiotherapy with hormonal treatment, 3  brachytherapy. The median age was 65  years (50-79). The initial staging was 17  T1, 23  T2  and 15  T3, 52  were N0  and N1 3. The median PSA was 12 (3-127). The Gleason score was less than 7, equal to 7  and greater than 7  at 21, 25  and 9  @entity1 respectively. The average time to recurrence was 69.5  months (8-147) with a median PSA of 2.9ng/mL (0.48-41). RESULTS: In 42  cases, F-PET/CT showed uptake, suggesting a recurrence, metastatic (6), nodal (26) or local isolated (10). The focal uptake in PET commissioned in 5  cases prostate biopsy, confirming the histological recurrence of @entity263 in 4  cases. Among the 10  @entity1 with isolated local recurrence, 8  underwent salvage radiotherapy. Of the 13  cases where the (F-PET/CT) showed no recurrence, 7  multiparametric MRI were performed. The MRI showed a local recurrence in 3  @entity1 , the diagnoses were confirmed with prostate biopsy for two of them. CONCLUSION: In our study, for the @entity1 with biochemical relapse of @entity263 localized or locally advanced, (F-PET/CT) was able to detect local recurrence isolated in nearly half the cases but did not show sufficient sensitivity to exclude recurrence local if negative. It does not replace MRI or additional prostate biopsy. LEVEL OF EVIDENCE: 5.
