Functional connectivity in mild XXXX .

@entity1 @entity131 @entity73 @entity1233 @entity130
OBJECTIVES: Research suggests that the majority of mild @entity131 (mTBI) @entity1 exhibit both @entity73 within the first weeks of @entity130 , followed by symptom resolution 3-6 months postinjury. The neuronal correlates of said dysfunction are difficult to detect with standard clinical neuroimaging, complicating differential diagnosis and early identification of @entity1 who may not recover. This study examined whether resting state functional magnetic resonance imaging (fMRI) provides objective markers of @entity130 and predicts @entity73 in mTBI @entity1 semiacutely (<3 weeks postinjury) and in late recovery (3-5 month) phases. METHODS: Twenty-seven semiacute mTBI @entity1 and 26 gender, age, and education-matched controls were studied. Fifteen of 27 @entity1 returned for a follow-up visit 3-5 months postinjury. The main dependent variables were spontaneous fluctuations (temporal correlation) in the default-mode ( @entity1233 ) and fronto-parietal task-related networks as measured by fMRI. RESULTS: Significant differences in self-reported @entity73 were observed (all P < 0.05), despite normal clinical (T1 and T2) imaging and neuropsychological testing results. Mild @entity131 @entity1 demonstrated decreased functional connectivity within the @entity1233 and hyper-connectivity between the @entity1233 and lateral prefrontal cortex. Measures of functional connectivity exhibited high levels of sensitivity and specificity for @entity1 classification and predicted @entity73 in the semi-acute @entity130 stage. However, no changes in functional connectivity were observed across a 4-month recovery period. CONCLUSIONS: Abnormal connectivity between the @entity1233 and frontal cortex may provide objective biomarkers of mTBI and underlie @entity73 .
