@entity62 associated with freezing of gait in XXXX .

@entity1 @entity717 @entity2686 @entity191 @entity9479 @entity6556 @entity62
UNASSIGNED: In @entity191 ( @entity191 ), freezing of gait ( @entity6556 ) is associated with widespread functional and structural gray matter changes throughout the brain. Previous study of freezing-related white matter changes was restricted to brainstem and cerebellar locomotor tracts. This study was undertaken to determine the spatial distribution of white matter damage associated with @entity6556 by combining whole brain and striatofrontal seed-based diffusion tensor imaging. Diffusion-weighted images were collected in 26 @entity191 @entity1 and 16 age-matched controls. @entity191 groups with (n   =   11) and without freezing of gait (n   =   15) were matched for age and disease severity. We applied tract-based spatial statistics to compare fractional anisotropy and mean diffusivity of white matter structure across the whole brain between groups. Probabilistic tractography was used to evaluate fractional anisotropy and mean diffusivity of key subcortico-cortical tracts. Tract-based spatial statistics revealed decreased fractional anisotropy in @entity191 with @entity6556 in bilateral cerebellar and superior @entity2686 . Increased mean diffusivity values were apparent in the right internal capsule, superior frontal cortex, anterior corona radiata, the @entity9479 , and cerebellum. Tractography showed consistent white matter alterations in striatofrontal tracts through the putamen, caudate, pallidum, subthalamic nucleus, and in connections of the cerebellar peduncle with subthalamic nucleus and pedunculopontine nucleus bilaterally. We conclude that @entity6556 is associated with diffuse white matter damage involving major cortico-cortical, corticofugal motor, and several striatofrontal tracts in addition to previously described cerebello-pontine connectivity changes. These distributed @entity62 may contribute to the motor and non-motor correlates of @entity6556 .    2015 International Parkinson and @entity717 Society.
