The presence of XXXX is a strong predictor of @entity9 in symptomatic knee osteoarthritis: a cross-sectional pilot study.

@entity1 @entity353 @entity571 @entity937 @entity75 @entity158 @entity236 @entity9
INTRODUCTION: @entity158 in @entity571 ( @entity571 ) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the @entity158 . Peripheral and central sensitization have been suggested as two of the underlying mechanisms that contribute to @entity158 in @entity571 . The aim of this study was to explore in symptomatic knee @entity571 @entity1 , the structural changes assessed by magnetic resonance imaging (MRI) that could be used as markers of @entity9 ( @entity9 ). METHODS: This cross-sectional observational pilot study included 50 knee @entity571 @entity1 with moderate to severe @entity158 (VAS >= 40) in the target knee. The presence of @entity9 was determined based on the PainDETECT questionnaire. Among the 50 @entity1 included, 25 had PainDETECT score  <=12 (unlikely @entity9 ), 9 had PainDETECT score between 13 and 18 (uncertain @entity9 ) and 16 had PainDETECT score >= 19 (likely @entity9 ). WOMAC, PainDETECT, and @entity158 scores as well as knee MRI were assessed. RESULTS: Data showed no significant difference in demographic characteristics between the three groups. However, a positive and statistically significant association was found between the WOMAC @entity158 (P <0.001), function (P <0.001), @entity353 as well as higher @entity158 score (P   =   0.023), and PainDETECT scores. Although no difference was found in the cartilage volume between groups, the presence of meniscal extrusion in both medial (P   =   0.006) and lateral (P   =   0.023) compartments, and presence of @entity937 in the lateral compartment (P   =   0.011), were significantly associated with increasing PainDETECT score. Moreover, the presence of @entity236 in the lateral plateau and the extent of the synovial membrane thickness in the lateral recess were associated with increasing PainDETECT scores (P   =   0.032, P   =   0.027, respectively). CONCLUSIONS: In this study, @entity75 , particularly extrusion, were found to be among the strongest risk factors for @entity9 in knee @entity571 @entity1 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01733277. Registered 16 November 2012.
