Enhanced selective @entity750 depletions in the @entity587 XXXX model: denervation supersensitivity and recovery of function.

@entity146 @entity1128 @entity2476 @entity1957 @entity3579 @entity854 @entity750 @entity29782 @entity35 @entity587
The effects of enhancing @entity750 depletion with multiple intracisternal injections of @entity1128 ( @entity587 ) on spontaneous or @entity29782 ( @entity2476 )-induced behaviors (videotaped) and locomotor activity (photocell recording) were studied in the adult @entity35 . After four @entity587 injections, @entity750 content in septum/accumbens, hippocampus, striatum, neocortex, cerebellum, and cervical spinal cord fell to 0-10% of controls. Multiple injections also significantly improved depletions in brainstem and diencephalon, which were not as extensive. Spontaneous locomotor activity (LMA) was increased in @entity587 -lesioned @entity35 for 1 week. The associated @entity146 , hindlimb @entity3579 and incomplete rearing were also transient and differed from the @entity1957 evoked by @entity2476 . Multiple @entity587 injections did not qualitatively modify the @entity2476 syndrome but shifted the dose response curve to the left compared to single injections. @entity146 shared a similar dose threshold and could be evoked with 30 mg/kg @entity2476 . Two weeks after @entity587 , the locomotor response to @entity2476 (65 mg/kg) was method dependent or biphasic: decreased in brief recordings when @entity854 were greatest and increased in hour-long recordings. LMA correlated with rearing in controls and inversely with @entity146 in @entity587 -lesioned @entity35 injected with @entity2476 . Multiple regression of LMA with regional @entity750 content was significant for hippocampus, striatum, and septum/accumbens. These data suggest that the development of denervation supersensitivity, the proposed mechanism of the @entity2476 -evoked @entity1957 , may be responsible for the rapid recovery of function in LMA.(ABSTRACT TRUNCATED AT 250 WORDS)
