Exertional Heat @entity64 and Susceptibility to Malignant XXXX in an Athlete: Evidence for a Link?

@entity1 @entity64 @entity13868 @entity5925 @entity590 @entity73327 @entity881 @entity221 @entity2753
OBJECTIVE:    To describe the possible association (pathophysiologic and clinical features) between exertional @entity64 (EHS) and @entity590 ( @entity590 ). BACKGROUND:    Both EHS and @entity590 are acute and life-threatening disorders. It has repeatedly been shown that EHS can occur in well-trained @entity1 with known @entity590 -associated mutation in the @entity13868 gene in the absence of any extreme environmental conditions or extreme physical activity, thereby supporting a possible link between EHS and @entity590 . In this case, a highly trained 30-year-old male athlete suddenly collapsed while running. He had initial @entity221 (40.2  C) and progressive @entity881 requiring medical management in an intensive care unit. After he recovered completely, a maximal exercise test was performed and showed an obvious abnormality of oxidative metabolism in muscle; genetic analysis of the @entity13868 gene identified a heterozygous missense variation @entity73327 . Consequently, the athlete was given appropriate information and allowed to progressively return to sport competition. DIFFERENTIAL DIAGNOSIS:    Doping, use of drugs and toxic agents, exercise-associated @entity2753 , exertional @entity221 . TREATMENT:    Initial management started with the basic resuscitative guidelines of airway, breathing, and circulation (intubation). Cooling, administration of fresh frozen plasma, and intensive rehydration resulted in improvement. UNIQUENESS:    To our knowledge, ours is the first description of this @entity590 mutation ( @entity73327 ) in the @entity13868 gene that was associated with exertional @entity5925 involving a dramatic impairment of oxidative metabolism in muscle. CONCLUSIONS:    Common features are shared by EHS and @entity590 . Careful attention must therefore be paid to athletes who experience EHS, especially in temperate climates or when there are no other predisposing factors.
