XXXX of the female breast in a sub-Saharan African population.

@entity1 @entity0 @entity5 @entity189 @entity3923 @entity1613 @entity1557
@entity0 is the second most frequent @entity5 in African females. @entity0 in African females appear about a decade earlier and follow a more aggressive clinical course than those in developed countries. To elucidate this difference we investigated 63 biopsied benign lesions of the female breast for their potential to malignant progression. We also performed histologic typing and grading of 184 female @entity0 received at the Muhimbili University Hospital in Dar es Salaam, Tanzania. @entity3923 and @entity1557 were the most frequent lesions. The majority of @entity1 with @entity3923 had no proliferative lesion and thus were not at a significantly increased risk of developing @entity0 . For @entity1557 , no indication for @entity1613 was found. The vast majority of @entity0 investigated were invasive. As a striking feature, the majority of those studied (66%) were of the non-special type (NST), displaying a more aggressive behaviour than the remaining @entity5 of the special type (ST). In the group of @entity5 , cribriform types constituted 41% of the cases which may be a special feature of the @entity189 in African females. Among the NST, the @entity5 were either of grade II or grade III, whereas in ST, 25% of the cases were of grade I. Since histology observed in this study is comparable to that seen in @entity1 from the Western society, late hospital presentation with advanced @entity5 stages may be a major reason for differences in clinical behaviour between African and Western females. A genetic factor, however, may be an important contributing factor.
