Local immune responses in the XXXX cerebral cortex after middle cerebral artery occlusion.

@entity64 @entity18895 @entity2806 @entity11264 @entity1188 @entity35 @entity792 @entity1590
This study describes local immune responses in @entity2806 induced by permanent occlusion of the middle cerebral artery (MCAO) in the @entity35 . The temporal and spatial pattern of leukocyte infiltration was characterized immunocytochemically using monoclonal antibodies against @entity18895 , a pan T cell marker, against @entity11264 and CD8 for subtyping of T lymphocytes, and ED1, a marker for macrophages. @entity18895 + T cells were present in some animals on the pial surface at day 1 and with increasing numbers mainly at the edges of the @entity1188 at days 3 and 7. By day 14 their number had significantly decreased. Subtyping of T lymphocytes revealed that @entity11264 + helper/inducer T cells were rare, while CD8+ lymphocytes were abundant. Moreover, CD8+ lymphocytes outnumbered @entity18895 + T cells indicating the presence of @entity18895 -/CD8+ natural killer (NK) cells. ED1+ macrophages primarily infiltrated the core of the @entity1188 starting on day 1. Infiltrating leukocytes expressed leukocyte function associated antigen-1 and MHC class I and II antigens. Early after @entity1188 , increased expression of the @entity1590 was found on vessels and leukocytes. In conclusion, this study shows that lymphocytes enter the nervous system not only in @entity792 , but also in response to primarily 'non-immune' neuronal damage such as @entity64 .
