Impact of oligon central venous catheters on catheter colonization and catheter-related XXXX .

@entity1 @entity902 @entity575 @entity281 @entity505 @entity2636 @entity3676
OBJECTIVE: To evaluate a new antimicrobial treatment for central venous catheters in comparison with a traditional treatment, by assessing the catheter colonization and catheter-related @entity281 rates in two groups of @entity1 . DESIGN: Multiple-center, prospective randomized study. SETTING: The medical and surgical departments of ten institutions. @entity1 : @entity1 requiring a central venous catheter for medical or surgical pathologies between June 2000 and November 2001. INTERVENTIONS: @entity1 in the control group received a conventional @entity3676 -treated double-lumen central venous catheter, while @entity1 in the oligon group received an oligon-treated ( @entity2636 combined with @entity575 , @entity505 , and @entity902 ) catheter with the same characteristics. Data collection included demographics, preexisting clinical conditions, main pathology, catheter insertion, and management data. Catheter colonization was defined as the growth of > or = 15 colony-forming units in culture of catheter segments by the roll-plate method, or > or = 1000 colony-forming units for the sonication method, and catheter-related @entity281 was defined as isolation of the same organism from the colonized catheter and from the peripheral blood of a @entity1 with clinical signs of @entity281 . MEASUREMENTS AND MAIN RESULTS: Data were obtained from 545 catheters. Of these, 132 catheters (24.2%) were positive for colonization. @entity1 in the oligon group demonstrated a lower risk for catheter colonization in the overall population (relative risk, 0.63; 95% confidence interval, 0.46-0.86; p = .003) and in the surgical subgroup (relative risk, 0.5; 95% confidence interval, 0.33-0.76;p = .001). Significant differences between groups were detected for coagulase-negative staphylococci and Gram-negative bacilli colonization rates. Twenty-one @entity1 (3.8%) were positive for catheter-related @entity281 , without significant differences between control and oligon groups. CONCLUSIONS: Oligon treatment is effective in limiting the catheter colonization rate. Due to the limited amount of events, this study lacked the power to detect significant differences in terms of catheter-related @entity281 rate.
