Farm characteristics, XXXX , and risk of non-hodgkin lymphoid neoplasms in the agricultural health study.

@entity2214 @entity1 @entity706 @entity566 @entity2490 @entity1582 @entity56 @entity1460 @entity1893
BACKGROUND: Because of unique exposures, studies among farmers may yield insights into the relationship between @entity566 and @entity706 . We evaluated farm characteristics, @entity56 and conditions, and risk of @entity1893 including specific subtypes in the Agricultural Health Study, a prospective cohort of farmers and spouses from North Carolina and Iowa. METHODS: We identified 710 incident cases of @entity1893 (including chronic @entity2214 and @entity1582 ) among 82,370 @entity1 with baseline data on crop and animal exposures, including 454 cases among 52,850 @entity1 with baseline data on @entity566 ( @entity2490 ) and living on a farm during childhood. HR and 95% confidence intervals (CI) were calculated using multivariable-adjusted proportional hazards models. RESULTS: We observed reduced risks of @entity1893 among farmers and spouses with @entity2490 at baseline (HR, 0.63; 95% CI, 0.51-0.79), related to growing @entity1460 (HR, 0.80; 95% CI, 0.67-0.96), and among farmers who handled stored grains or hay (HR, 0.66; 95% CI, 0.52-0.82). Growing up on a farm was associated with @entity1893 (HR, 1.51; 95% CI, 1.15-1.98). Results did not differ significantly by @entity1893 subtype. CONCLUSIONS: Both the reduced risk of @entity1893 among those with @entity566 and specific farm exposures in adulthood, and the increased risk among those who grew up on a farm suggest that the host immune response to agricultural allergens may influence @entity1893 development. IMPACT: This prospective study is, to our knowledge, the first to investigate the relationship between @entity566 and @entity1893 risk in farmers; confirmation of these findings in other farming populations is warranted. Cancer Epidemiol Biomarkers Prev; 24(3); 587-94.   2015 AACR.
