[Clinical studies with XXXX in the biliary disease].

@entity1 @entity7048 @entity5990 @entity2891 @entity12706 @entity5579
The concentration of @entity2891 ( @entity5579 ) in serum and bile was estimated after intravenous drip infusion of 1 g of the drug in 11 @entity1 , who have performed cholecystectomy, choledocholithotomy and T-tube drainage for @entity5990 . Administration of @entity7048 ( @entity12706 ) 1 g was compared by the cross over method. After 1 g intravenous drip infusion of @entity5579 , the mean serum concentration was 88.3 +/- 24 micrograms/ml at 1 hour, 52 +/- 11.7 micrograms/ml at 2 hours and 36.5 +/- 10 micrograms/ml at 4 hours. The maintenance period of serum concentration was inclined to be longer in @entity5579 than in @entity12706 . After 1 g intravenous drip infusion of @entity5579 , the mean bile concentration reached to 810 +/- 459 micrograms/ml in 2 hours and it was maintained as high as 562 +/- 319 micrograms/ml even after 4 hours. On the other hand, after 1 g intravenous drip infusion of @entity12706 , the mean bile concentration was only 28.7 +/- 26 micrograms/ml in 1 hour and was low level in the progress. As compared with the highest concentration of @entity5579 and @entity12706 in same @entity1 , the mean bile concentration of @entity5579 (942 +/- 525 micrograms/ml) was about 30 times higher than that of @entity12706 (28.6 +/- 26.3 micrograms/ml). There was no difference in the group of Gram-positive cocci between minimum inhibitory concentration (MIC) of @entity5579 and that of @entity12706 . While MIC of @entity12706 in the group of Gram-negative bacilli was from 0.78 to over 400 micrograms/ml, MIC of @entity5579 in that group was from 0.10 to 50 micrograms/ml. The value in @entity5579 was lower than that in @entity12706 at all strains. No side effects was seen in all @entity1 .
