Perfusion quantification of XXXX using contrast-enhanced ultrasound (CEUS) with time intensity curve analysis before and after treatment: First  results.

@entity1 @entity7026 @entity599 @entity1211 @entity1462
AIM: Aim of this pilot-study was to quantify perfusion changes of @entity1462 before and after the first interventional treatment using contrast-enhanced ultrasound (CEUS). MATERIAL AND METHODS: 29 @entity1 (10 male, 19 female) between 6 and 63 years (mean 25.8 years) with 12 arterio-venous ( @entity7026 ) and 17 @entity1211 ( @entity1211 ) were examined before and after their first percutaneous interventional treatment. CEUS was performed with a 2.4ml bolus injection of @entity599 -hexafluorid microbubbles, and a 6-9MHz mulitfrequency transducer. A 60sec cine sequence was recorded and regions of interest (10mm * 30mm) were defined in the centre, and the margins of the @entity1462 as well as in the surrounding healthy tissue. Time Intensity Curves (TIC) were analysed, and Time to Peak (TTP) as well as Area under the Curve (AUC) were calculated. RESULTS: For VMs there was a significant perfusion difference (p< 0.05) in AUC between centre and the surrounding tissue before (332.1 vs. 130.4 rU) and after treatment (331.0 vs. 106.9 rU). There was no significant difference for TTP in ROIs of @entity1211 (19.1 vs. 26.5sec). After the treatment there was a significant decrease in AUC for all three regions in AVMs, and an increase in TTP for AVMs. However TTP for AVMs in the centre ROI still remained shorter than in the surrounding tissue even after therapy (20.9 vs. 25.4sec). CONCLUSION: CEUS with TIC analysis is a promising imaging method for the evaluation of perfusion before and after percutaneous treatment of @entity1462 . AUC decrease indicates therapy-induced changes in perfusion of @entity1211 whereas an increase in TTP shows therapy-related changes in @entity7026 .
