Impact of radiation therapy on acute @entity137 in breast conservation therapy for early XXXX .

@entity1 @entity137 @entity0 @entity4 @entity1398
AIMS: To document the acute @entity137 experienced by @entity1 receiving radiation therapy as part of breast-conservation therapy (BCT) for early @entity0 . MATERIALS AND METHODS: A retrospective review was undertaken of the medical records of 234 consecutive @entity1 managed with radiation therapy for BCT over a 2-year period. A policy of formal acute @entity137 documentation was present during this period with descriptive measures as well as the Radiation Therapy Oncology Group (RTOG) acute @entity137 scoring system. Cutaneous moist desquamation, peak RTOG score, breast @entity4 and chemotherapy dose intensity were end points assessed. @entity1 and treatment characteristics were investigated for their association with study end points using Chi-squared and logistic regression analyses. RESULTS: A total of 223 (95%) of @entity1 had data available for analysis. All @entity1 were treated with tangential fields on megavoltage linear accelerators. Eighty-three (37.2%) @entity1 had systemic chemotherapy either delivered simultaneously in 58 and sequentially in 25. Moist desquamation occurred in 70 (31.4%) @entity1 ; principally in the inframammary fold only in 43 (19.3%). Only 12 (5.4%) had a confluent moist reaction. Two hundred and ten (94%) @entity1 had a peak RTOG skin grade of 2 or less. Breast @entity4 was evident at treatment end in 46 (20.5%). On univariate analysis, physical factors, such as @entity1 weight (P<0.001) and breast size (P<0.001), were significantly associated with moist desquamation, as were the volume of breast resected (P=0.02) and the use of chemotherapy (P=0.03). Only the physical factors remained significant on multivariate analysis. The presence of breast @entity4 was associated with surgical factors such as post-operative @entity4 (P<0.001). The use of concurrent chemoradiotherapy did not affect chemotherapy dose intensity, nor did the presence of moist desquamation increase the risk of febrile complications in chemotherapy-related @entity1398 . CONCLUSION: This study confirms the relatively low incidence of significant acute @entity137 experienced by @entity1 during radiation therapy as part of BCT. These study data should assist surgeons and @entity1 in the decision-making process for BCT.
