MicroRNA-574 is involved in XXXX in 5-month-old APP/ @entity20933 @entity19 through regulation of neuritin.

@entity71613 @entity20933 @entity71612 @entity303 @entity73 @entity19 @entity195
UNASSIGNED: @entity195 ( @entity195 ) is the most common form of @entity303 in the elderly. The recent evidence in @entity195 research suggests that alterations in the microRNA (miRNA) could contribute to risk for the disease. However, little is understood about the roles of miRNAs in @entity73 of early @entity195 ( @entity195 ). Here, we used 5-month-old APP/ @entity20933 @entity19 , which mimic many of the salient features of the early stage of @entity195 pathological process, to further investigate the roles of miRNAs in synaptic loss involved in learning and memory. We used miRNA expression microarrays on RNA extracted from the hippocampus of 5-month-old APP/ @entity20933 @entity19 and wild type @entity19 . Real-time reverse transcription PCR was conducted to verify the candidate miRNAs discovered by microarray analysis. The data showed that @entity71612 was increased significantly in the hippocampus of 5-month-old APP/ @entity20933 @entity19 , which were concomitant with that APP/ @entity20933 @entity19 at the same age displayed a significant synaptic loss and @entity73 . Bioinformatic analysis predicted that neuritin ( @entity71613 ) mRNA is targeted by @entity71612 . Overexpression of @entity71612 lowers the levels of neuritin and synaptic proteins expression in primary hippocampal neurons damage induced by Ab25-35. And the expression of @entity71612 was also up-regulated in the hippocampal neurons from APP/ @entity20933 @entity19 compared with WT littermates. In contrast, suppression of @entity71612 by @entity71612 inhibitor significantly results in higher levels of neuritin and synaptic proteins expression. Taken together, @entity71612 is involved in @entity73 in 5-month-old APP/ @entity20933 @entity19 through regulation of neuritin.
