Beneficial effect of moderate protein restriction on growth, renal function and survival in young XXXX with chronic renal failure.

@entity972 @entity851 @entity1372 @entity740 @entity1391 @entity460 @entity2865 @entity35 @entity1011
We used the model of one-stage uninephrectomy and contralateral heminephrectomy to study the effect of protein restriction on growth and renal function in young (starting age 21 d) female @entity35 . Normal, sham-operated, pair-fed, and @entity740 ( @entity740 ) @entity35 were fed a 6, 14 or 22% protein (casein) diet. Diets were otherwise isoenergetic and equivalent in @entity1372 , @entity972 , @entity2865 , @entity1391 and @entity460 . Weight, length, urinary protein and @entity1011 clearances were measured up to 6 mo of age. Regardless of group (normal, sham or @entity740 ), animals fed a 6% protein diet weighed less and were shorter than animals fed 14 or 22% protein diets. No difference in growth could be found between 14 and 22% protein intake. However, animals with @entity740 fed 22% protein diet had a shorter survival time than animals fed 14 or 6% protein diets. Six percent protein intake led to a lower growth rate over the first 10-12 wk of age than 14 or 22% protein intake. We conclude that 14% protein intake in @entity35 with @entity740 maintains normal growth and improves survival over 22% protein intake. @entity35 with @entity740 fed a 6% protein diet have improved survival compared to @entity35 fed a 22% protein diet but suffer @entity851 .
