XXXX : A Single-Center Experience.

@entity1 @entity1071 @entity5 @entity3470 @entity1892
BACKGROUND: @entity1071 ( @entity1071 ) is the second most common @entity5 after adult kidney transplantation (KT). METHODS: We retrospectively analyzed 8 adult @entity1 who underwent KT in our center, diagnosed with @entity1071 between 2001 and 2014. RESULTS: Six @entity1 were @entity1 . The median age at presentation was 43 years and the median time since transplantation was 7.3 years. Three @entity1 had previously received anti-thymocyte globulin/OKT3, and all were taking calcineurin inhibitors (CNI) at diagnosis. The monomorphic type was the most common, with diffuse large @entity1892 as the origin. The most frequent presentation was fever. Four in five @entity1 had @entity1071 . All @entity1 received various regimens of immunosuppression reduction (IR), with 4 converting CNI to @entity3470 inhibitor (imTOR). Subsequent treatment (when needed) was chemotherapy, radiotherapy, and surgery. The maximum follow-up time was 6.7 years, with a 50% mortality rate that occurred at a median time of 3.5 months (2 died with functioning kidney). All 4 @entity1 who were in remission at the end of follow-up had CNI conversion to imTOR, and none lost the allograft. CONCLUSIONS: Despite the small number of cases, our results confirm the high @entity1071 impact in overall and allograft survival. Our @entity1071 type distribution is in accord with the literature. First-line @entity1071 treatment is IR, but the best method is still unknown; our results may suggest a beneficial effect of CNI conversion to imTOR.
