Contemporary neonatal outcome following rupture of membranes prior to 25 weeks with prolonged XXXX .

@entity1 @entity358 @entity842 @entity1576 @entity2906 @entity1964
BACKGROUND: Prolonged @entity2906 following early preterm prelabour rupture of membranes (PPROM) is traditionally associated with high neonatal mortality and significant risk of @entity358 . However, recent evidence points to an apparent improvement in outcome. AIMS: To document current neonatal outcomes following rupture of membranes prior to 25 weeks with severe persistent @entity2906 and a latency to delivery of at least 14 days. METHODS: A retrospective case note analysis over a 28-month period at Saint Luc University Hospital, Brussels. RESULTS: From 23 pregnancies that were complicated by PPROM prior to 25 weeks, 15 @entity1 were born after 24 weeks with a latency of more than 14 days and persistent @entity2906 . Nine @entity1 (60%) had severe @entity1576 and clinical signs compatible with @entity358 . Seven of these @entity1 (78%) responded to high frequency ventilation and inhaled @entity842 therapy with good clinical outcome but two died from severe @entity1576 . Five @entity1 showed no clinical signs of @entity358 and responded to conventional neonatal management. One of these @entity1 died at 77 days of age of @entity1964 . One @entity1 was not resuscitated and died within minutes of birth, following prior discussion with the perinatal team and the parents. Survivors in this high-risk group (73%) had low morbidity at the time of discharge. SUMMARY: The favourable neonatal survival and morbidity figures are in keeping with recent published evidence. This study confirms improved outcome even amongst the highest risk @entity1 with documented persistent @entity2906 .
