Role of local and distant functional connectivity density in the development of minimal XXXX .

@entity1 @entity99 @entity1987
The progression of functional connectivity (FC) patterns from non- @entity99 (non-HE) to @entity1987 ( @entity1987 ) is not well known. This resting-state functional magnetic resonance imaging (rs-fMRI) study investigated the evolution of intrinsic FC patterns from non-HE to @entity1987 . A total of 103 cirrhotic @entity1 ( @entity1987 , n   =   34 and non-HE, n   =   69) and 103 healthy controls underwent rs-fMRI scanning. Maps of distant and local FC density (dFCD and lFCD, respectively) were compared among @entity1987 , non-HE, and healthy control groups. Decreased lFCD in anterior cingulate cortex, pre- and postcentral gyri, cuneus, lingual gyrus, and putamen was observed in both @entity1987 and non-HE @entity1 relative to controls. There was no difference in lFCD between @entity1987 and non-HE groups. The latter showed decreased dFCD in inferior parietal lobule, cuneus, and medial frontal cortex relative to controls; however, @entity1987 @entity1 showed decreased dFCD in frontal and parietal cortices as well as increased dFCD in thalamus and caudate head relative to control and non-HE groups. Abnormal FCD values in some regions correlated with @entity1987 @entity1 ' neuropsychological performance. In conclusion, lFCD and dFCD were perturbed in @entity1987 . Impaired dFCD in regions within the cortico-striato-thalamic circuit may be more closely associated with the development of @entity1987 .
