Natural killer cell activity in long-term survivors of XXXX . Influence of cytostatic therapy and initial stage of disease.

@entity1 @entity12962 @entity137 @entity2940 @entity5 @entity3003 @entity900 @entity2879 @entity10711 @entity1732 @entity4797 @entity3
BACKGROUND: @entity1 with @entity5 can be cured by @entity900 -based chemotherapy in many cases. Thus, concern about possible late @entity137 of treatment is warranted. METHODS: In this investigation, the absolute number of natural killer (NK) cells according to their @entity2940 + phenotype, NK cell activity, and @entity137 ( @entity137 ) were investigated in 29 @entity1 with @entity4797 or @entity10711 ( @entity10711 ) a median of 31 months (range, 5-73 months) after termination of chemotherapeutic treatment. RESULTS: No difference in the absolute number of NK cells, NK cell activity, and @entity137 was found between @entity1 with @entity5 after either standard polychemotherapy consisting of @entity1732 , @entity2879 , and @entity900 ( @entity12962 ) or monotherapy with @entity3003 and healthy control subjects. When @entity1 were analyzed further using multivariate analysis, a significant (P < 0.05) detrimental influence of @entity12962 polychemotherapy versus @entity3003 monotherapy on NK cell activity was found. Moreover, NK cell activity also depended significantly (P < 0.05) on the time elapsed after chemotherapy was administered, but normalized with time. Because the absolute number of NK cells was not affected, is was assumed that polychemotherapy induced a functional defect. In a subanalysis of @entity1 with NSGCTs, @entity3 at diagnosis resulted in a significant (p < 0.05) and persistent stimulation of NK cell activity but not of @entity137 . CONCLUSION: Cytostatic chemotherapy in @entity1 with @entity5 did not lead to compromised lytic effector cell function as assessed by NK cell activity and @entity137 . However, a short, time-dependent reduction was found that also depended on the intensity of chemotherapeutic treatment. This finding related to the observation of a long-lasting stimulus of NK cell activity by initial @entity3 in @entity1 with NSGCTs.
