Pilot study of salvage laparoscopic prostatectomy for the treatment of recurrent XXXX .

@entity1 @entity323 @entity263 @entity834 @entity1069 @entity322 @entity3 @entity850 @entity130
OBJECTIVE:     To evaluate feasibility, safety and oncological efficacy of salvage laparoscopic radical prostatectomy for pathology-proven biochemical recurrence after primary radiation therapy or cryotherapy for @entity263 . MATERIALS AND METHODS:     This retrospective pilot study examined 15 @entity1 from 2004 to 2010 with biochemical recurrence after external beam radiation therapy (N= 8), brachytherapy (N= 6) or cryotherapy (N= 1).     @entity1 were treated with salvage laparoscopic radical prostatectomy (11 conventional, four robotic-assisted) with bilateral pelvic dissection. RESULTS:     Median duration of surgery was 235 min. None of the following occurred: conversion to open surgery, transfusion, urethrovesical @entity850 or perioperative or postoperative mortality. One @entity1 presented with a @entity130 , repaired using uninterrupted sutures and a colostomy. One @entity1 had @entity834 treated with prolonged Foley catheterization.     Pathological stage was pT2a in three, pT2b in three, pT3a in four, pT3b in three and pT4 in two @entity1 ; two @entity1 had nodal @entity3 . Within an 8-month median follow-up, 11 @entity1 were disease-free and three had persistent postoperative @entity1069 ( @entity1069 ) elevation; the remaining @entity1 experienced @entity1069 recurrence after 21 months.     Seven @entity1 achieved continence (no pads) by 8.4 months (median), one @entity1 manifested severe @entity322 corrected by implanting an artificial sphincter, and seven @entity1 with a 12.6-month mean follow-up continued to need one or two pads per day.     @entity323 was present in five @entity1 before surgery and in 14 @entity1 after surgery. CONCLUSION:     Salvage laparoscopic radical prostatectomy seems to offer a safe therapeutic alternative for @entity1 failing primary radiation or cryotherapy. However, larger studies with longer-term data are required.
