Non-steroidal anti-inflammatory drug use and risk of XXXX : A systematic review and meta-analysis of observational studies.

@entity5 @entity1 @entity117 @entity1204
OBJECTIVE: Non-steroidal anti-inflammatory drug (NSAID) use has been linked to a reduction in the risk of several @entity5 types. For @entity1204 , however, results have been inconsistent. To summarize the available evidence on the risk of @entity1204 associated with use of @entity117 or non- @entity117 (NA-) NSAIDs, we performed a systematic review and meta-analysis of observational studies. METHODS: We conducted a bibliographic database search in PubMed, Embase and Cochrane Library. Relative risk estimates were extracted from eligible case-control and cohort studies and pooled using a random effects model. RESULTS: Six case-control and seven cohort studies were found eligible for our meta-analysis. We observed risk reductions in @entity1204 associated with regular use of @entity117 (case-control: 11%, cohort: 8%) and NA-NSAIDs (case-control: 9%, cohort: 6%), compared to non-use. However, the pooled risk ratios were not statistically significant. Higher risk reductions were seen with high frequency of notably @entity117 use (case-control: 37%, cohort: 20%). The inverse association between regular @entity117 use and @entity1204 risk was strongest among @entity1 with a body mass index above 30 (case-control: 44%, cohort: 20%). CONCLUSIONS: Regular use of @entity117 or NA-NSAIDs was associated with a marginally reduced risk of @entity1204 . Larger risk reductions were linked with high frequency of NSAID use and high BMI.
