@entity653 -induced fluid shifts attenuate the vestibulosympathetic reflex in XXXX .

@entity1 @entity653 @entity432 @entity717 @entity291
The @entity653 dehydration test (GDT) has been used to test for the presence of M  ni  re's disease and elicits acute alterations in vestibular reflexes in both normal and pathological states. Activation of the vestibulosympathetic reflex (VSR) increases muscle sympathetic nerve activity (MSNA) and peripheral vascular resistance. We hypothesized that the GDT would attenuate the VSR through fluid shifts of the inner ear. Sixteen male subjects (26    1 yr) were randomly assigned to be administered either @entity653 mixed with cranberry juice (97    3 ml @entity653 + equal portion of cranberry juice; n = 9) or a placebo control [water + cranberry juice (100 ml each); n = 7]. Subjects in both groups performed @entity717 ( @entity717 ), which engages the VSR, before and after administration of either the @entity653 or placebo. MSNA (microneurography), arterial blood pressure, and leg blood flow ( @entity432 plethysmography) were measured during @entity717 . Before @entity653 administration, @entity717 significantly increased MSNA burst frequency (/\8    1 bursts/min; P < 0.01) and total activity (/\77    18%; P < 0.01) and decreased @entity291 vascular conductance (-/\20    3%; P < 0.01). However, @entity717 performed postadministration of @entity653 resulted in an attenuated MSNA increase (/\3    1 bursts/min, /\22    3% total activity) and decrease in @entity291 vascular conductance (-/\7    4%). @entity717 significantly increased MSNA burst frequency (/\5    1 and /\5    2 bursts/min) and total activity (/\58    13% and /\52    18%) in the placebo group before and after placebo, respectively (P < 0.01). Likewise, decreases in @entity291 vascular conductance during @entity717 before and after placebo were not different (-/\13    4% and -/\14    2%, respectively; P < 0.01). These results suggest that fluid shifts of the inner ear via @entity653 dehydration attenuate the VSR. These data provide support that inner ear fluid dynamics can have a significant impact on blood pressure regulation via the VSR in @entity1 .
