Prevention of pulmonary complications of pneumoperitoneum in XXXX .

@entity35 @entity548 @entity1219 @entity4 @entity384 @entity515 @entity544 @entity64117 @entity516
BACKGROUND: @entity544 ( @entity515 ) @entity516 facilitates the visualization of abdominal organs during laparoscopic surgery. However, the associated increase in intra-abdominal pressure causes oxidative stress, which contributes to tissue injury. OBJECTIVE: We investigated the ability of the antioxidant and anti-inflammatory drug @entity64117 to prevent @entity515 @entity516 -induced oxidative stress and inflammatory reactions in a @entity35 model. METHODS: Fourteen female adult @entity35 albino @entity35 were divided into a control group (Group A, n = 7) and an @entity64117 group (Group B, n = 7). Group A received 0.5 cc/day 0.9% @entity1219 , and Group B received 10 mg/kg/day @entity64117 was administered by gavage, and maintained for 7 days prior to the operation. During the surgical procedure, the @entity35 were exposed to @entity515 @entity516 with an intra-abdominal pressure of 15 mmHg for 30 min. The peritoneal gas was then desufflated. The @entity35 were sacrificed following 3 h of insufflation. Their lungs were removed, histologically evaluated, and scored for @entity548 , @entity4 , @entity384 , and leukocyte infiltration. The results were statistically analyzed. A value of P < 0.05 was considered statistically significant. RESULTS: Significant differences were detected in @entity548 (P < 0.05), @entity384 (P < 0.001), and leukocyte infiltration (P < 0.001) in Group A compared with Group B. However, the differences in @entity4 were not statistically significant (P = 0.698). CONCLUSIONS: @entity515 @entity516 results in oxidative injury to lung tissue, and administration of @entity64117 reduces the severity of pathological changes. Therefore, @entity64117 may be a useful preventive and therapeutic agent for @entity515 @entity516 -induced oxidative stress in laparoscopic surgery.
