Changes in immunocompetent cells after interstitial laser thermotherapy of XXXX .

@entity1 @entity0 @entity5 @entity8730 @entity469 @entity2225 @entity403 @entity3 @entity2902 @entity405 @entity4896
BACKGROUND: Local @entity5 destruction has been shown to give rise to changes in immunocompetent cells. The aim of this study was to describe the effect of interstitial laser thermotherapy (ILT) of @entity0 in the @entity5 and in regional lymph nodes. METHODS: Seventeen @entity1 that underwent radical surgical excision after non-radical ILT were studied. ILT was performed at a steady-state temperature of 48  C for 30  min. Surgical excision was performed 12 (6-23) days after ILT. Six @entity1 with @entity0 not treated with ILT before surgery served as controls. Immunohistological reactions were performed on core needle biopsies prior to treatment and on the excised specimens. RESULTS: ILT resulted in more @entity405 lymphocytes and @entity469 macrophages within the @entity5 (P  <  0.05 and P  <  0.01, respectively) and higher counts of @entity2225 (P  <  0.05), @entity469 (P  <  0.001) and @entity8730 (P  <  0.01) at the @entity5 border, when compared to pre-treatment values. In the control @entity1 not receiving ILT, @entity405 cells increased within the @entity5 after resection (P  <  0.05). With the probable exception of @entity2902 @entity403 cells, the presence of @entity5 in a lymph node influenced the findings in lymph nodes (examined for @entity4896 , @entity2902 , @entity403 @entity2902 , @entity8730 cells). Thus, comparisons between ILT and control @entity1 were restricted to @entity1 without lymph node @entity3 . In these @entity1 , ILT and resection were followed by a decrease in @entity2902 @entity403 lymphocytes (P  <  0.05), when compared to surgical resection alone. CONCLUSIONS: ILT induced changes in immunocompetent cells in @entity1 with @entity0 . The stimulation of the immune system is an added feature of ILT in treatment of @entity1 with @entity0 .
