[Prognostic significance of natural killer cell infiltration in XXXX ].

@entity5 @entity1 @entity157 @entity2940
BACKGROUND AND OBJECTIVE: Several studies have Shown the correlation of high numbers of @entity5 -infiltrating natural killer (NK) cells with a good prognosis for @entity5 @entity1 . This study was to investigate the impact of NK cell infiltration on the survival and prognosis of @entity1 with @entity157 ( @entity157 ) after resection. METHODS: The proportion of infiltrating NK cells of @entity157 @entity1 was measured using flow cytometry, and the expression of @entity2940 + (NK) cells was investigated using immunohistochemistry. Prognostic values of intratumoral and peritumoral NK cell densities were evaluated by Kaplan-Meier method and Cox regression. RESULTS: The level of NK cells was significantly lower in @entity5 -infiltrating lymphocytes (TIL) of @entity157 @entity1 than in nontumor-infiltrating lymphocytes (NIL) [(11.8 +/- 8.1)% vs. (18.0+/-7.9)%, P=0.002]. The density of NK cells was also significantly lower in @entity5 nests than in peritumoral lesions (2.3 +/- 2.6 vs. 8.5 +/- 4.5 cells per field, P<0.001). @entity1 with low intratumoral NK cells had shorter disease-free survival (P=0.027) and overall survival (P=0.005) than @entity1 with high intratumoral NK cells. In contrast, NK cells in the peritumoral area showed no prognostic significance for either disease-free survival or overall survival. Multivariate Cox proportional hazards analysis showed that intratumoral NK cell density was an independent prognostic factor of prolonged overall survival (hazard ratio = 2.658, P=0.019). CONCLUSION: Low NK cells infiltration could predict poor prognosis in @entity1 with @entity157 .
