Effect of XXXX in severe @entity1412 .

@entity1 @entity480 @entity1127 @entity2715 @entity1412 @entity5023
OBJECTIVES: To investigate the effect of intranasal corticosteroids in the treatment of @entity1127 in @entity1 with severe @entity1412 listed for surgical treatment and to determine the treatment effect on the progression of the disease. DESIGN: A double-blind, randomized, parallel-group, placebo-controlled, 12-week study at a single center. SETTING: A tertiary referral center in London, England. @entity1 : Thirty-four @entity1 with severe @entity1412 listed for endoscopic surgical treatment. INTERVENTION: By random allocation, @entity5023 aqueous nasal spray (FPANS), 200 microg twice a day; @entity2715 aqueous nasal spray, 200 microg twice a day; or placebo nasal spray twice a day was administered. @entity1 received 2 actuations to each nostril in the morning and in the evening. MAIN OUTCOME MEASURES: Efficacy end points were the need for polypectomy at the end of treatment, the results of acoustic rhinometry, the polyp score, the peak nasal inspiratory flow rate, and an assessment of symptoms. RESULTS: The polyp score was significantly decreased in the FPANS-treated group (P < or = .01). The nasal cavity volume was significantly increased in both the FPANS-treated group and the group receiving @entity2715 compared with placebo (P < or = .01) at the end of treatment. The percentage change in the mean morning peak nasal inspiratory flow rate was greater in the FPANS-treated group, with a significant effect observed at week 2 (P = .01). Nasal blockage was significantly decreased in both active groups compared with the group receiving placebo. No significant difference was observed between the treatment groups in the number of @entity1 requiring polypectomy. CONCLUSIONS: @entity5023 and @entity2715 aqueous nasal sprays are effective in treating the symptoms of severe @entity480 . There was some evidence that the group treated with FPANS responded more quickly to intervention and that the magnitude of the response was greater than in the group receiving @entity2715 .
