Multi-parametric (mp) MRI of XXXX .

@entity1 @entity1605 @entity263 @entity5 @entity420
BACKGROUND: @entity263 ( @entity420 ) is an aggressive variant of conventional @entity420 (CCa) with mixed @entity420 comprising up to 5% of all @entity263 . @entity420 may be underestimated on T2-weighted (T2W) MRI. This study assessed the mp-MRI appearance of @entity420 as compared with CCa. METHODS: With research ethics board approval, we identified 38 @entity1 who underwent mp-MRI (T2W, DWI, and DCE) and radical prostatectomy (RP) between 2012 and 2014. Eight @entity420 in 8 @entity1 and 39 CCa @entity5 foci in 30 consecutive @entity1 were identified. @entity5 volume, apparent diffusion coefficient (ADC;10(-3) mm(2) /s), and time-signal intensity (SI) curves were calculated. Parametric data were compared using the Kruskal-Wallis test and univariate regression. Time-SI curves were compared using the chi-square test. RESULTS: @entity5 volumes were: 1.62(  1.02) for @entity420 , 1.03(  0.54) for Gleason 9, 0.88(  0.93) for Gleason 7/8, and 0.26(  0.14) mL for Gleason 6. There was no difference in size between @entity420 and Gleason 9 (P   =   0.22); however, @entity420 were larger than Gleason 7/8 (P   =   0.03) and Gleason 6 (P   =   0.003) @entity5 . ADC values were: 0.789(  0.22) for @entity420 , 1.01(  0.19) for Gleason 9, 0.992(  0.23) for Gleason 7/8 and 1.389(  0.41) 10(-3) mm(2) /s for Gleason 6 @entity5 . There was no difference in ADC between @entity420 and Gleason 9 (P   =   0.14) or Gleason 7/8 (P   =   0.055) @entity5 . There was a difference in ADC for @entity420 and Gleason >= 7 CCa compared to Gleason 6 @entity5 , (P   <   0.001 and P   =   0.012). All @entity420 demonstrated type III time-SI curves. Gleason   >=    7 @entity5 demonstrated @entity1605 . Gleason 6 @entity5 demonstrated Type I/II time-SI curves. There was no difference in curve type between groups, (P   =   0.18). CONCLUSION: Although @entity420 mimics Gleason score 3   +   3   =   6 @entity5 at T2W MRI; @entity420 resembles Gleason >= 7 CCa on mp-MRI.
