Plastic changes in spinal synaptic transmission following botulinum toxin A in @entity1 with post- @entity64 XXXX .

@entity1 @entity64 @entity308 @entity508 @entity8108
OBJECTIVE: The therapeutic effects of intramuscular injections of botulinum toxin-type A on @entity508 can largely be explained by its blocking action at the neuromuscular junction. Botulinum toxin-type A is also thought to have a central action on the functional organization of the central nervous system. This study assessed the action of botulinum toxin-type A on spinal motor networks by investigating post-activation @entity308 of the soleus H-reflex in post- @entity64 @entity1 . @entity308 , a presynaptic mechanism controlling the synaptic efficacy of Ia-motoneuron transmission, is involved in the pathophysiology of @entity508 . @entity1 : Eight @entity1 with chronic @entity64 presenting with lower limb @entity508 and requiring botulinum toxin-type A injection in the ankle extensor muscle. METHODS: @entity308 of soleus H-reflex assessed as frequency-related @entity308 of H-reflex was investigated before and 3, 6 and 12 weeks after botulinum toxin-type A injections in the triceps surae. @entity308 was quantified as the ratio between @entity8108 -reflex amplitude at 0.5 and 0.1 Hz. RESULTS: @entity308 of soleus H-reflex, which is reduced on the paretic leg, was affected 3 weeks after botulinum toxin-type A injection. Depending on the residual motor capacity of the post- @entity64 @entity1 , post-activation @entity308 was either restored in @entity1 with preserved voluntary motor control or further reduced in @entity1 with no residual voluntary control. CONCLUSION: Botulinum toxin treatment induces synaptic plasticity at the Ia-motoneuron synapse in post- @entity64 paretic @entity1 , which suggests that the effectiveness of botulinum toxin-type A in post- @entity64 rehabilitation might be partly due to its central effects.
