The Predictive Value of Circulating XXXX Cells in @entity43 : A Meta Analysis.

@entity1 @entity43 @entity5
OBJECTIVE: Studies have confirmed that @entity1 with circulating @entity5 cells (CTCs) in their peripheral blood (PB) or disseminated @entity5 cells (DTCs) in bone marrow (BM) might have bad prognosis. In this paper, we discuss whether CTCs/DTCs would be an appropriate biomarker to predict the prognosis of @entity43 . METHODS: We systematically searched PubMed, EMBASE, Cochrane library, and Chinese National Knowledge Infrastructure to collect relevant studies published from the time the database were created to February 2014. Studies quality was assessed by Newcastle-Ottawa Scale. The effect size was estimated by hazard ratio (HR) and corresponding 95% confidence interval (95% CI). Meta-analysis was conducted with STATA Version 12.0. RESULTS: Eight studies of 1184 @entity1 were included in the final analysis. In the PB group, it showed that @entity1 with positive CTCs had significantly shorter overall survival and disease-free survival than @entity1 with negative CTCs (HR, 2.09; CI, 1.13-3.88 and HR, 1.72; CI, 1.32-2.25, respectively). The same result was shown with DTCs in the BM group (HR, 1.61; CI, 1.27-2.04 and HR, 1.44; CI, 1.15-1.80, respectively). We also discussed the influence of CTCs/DTCs on International Federation of Gynecology and Obstetrics stage, pathological grade with odds ratio and 95% CI. However, it did not show any statistical significance. CONCLUSIONS: The CTCs/DTCs might be a new biomarker to predict the prognosis of @entity43 . Future studies are needed to confirm this consequence.
