Combined modality therapy following bladder conservation surgery for XXXX .

@entity1 @entity1138 @entity150 @entity3 @entity2335
OBJECTIVE: To analyze the efficacy of recurrence prophylaxis using radiation and chemotherapy following bladder conservation surgery for muscle invasive @entity150 . METHODS: 23 @entity1 with muscle invasive @entity150 were treated with radiotherapy combined with bladder mitomycin infusion after bladder conservation surgery (study group). Radiotherapy was given using an external beam at an average dose of 5148 +/- 462 cGy with conventional fractionation. For comparison, 29 similar @entity1 treated with postoperative bladder @entity1138 infusion without radiation served as control (control group). All @entity1 were followed up for more than 3 years, an average of 41.6 months (36 - 60 months). RESULTS: The 3-year pelvic recurrent rate of muscle invasive @entity150 was 17.4% in the study group and 44.8% (P = 0.036) in the control group. The 3-year distant @entity3 rates were 17.4% and 24.1%, respectively (P = 0.554). The 3-year overall survival rates were 81.8% and 86.2%, respectively (P = 0.670). Two @entity1 from the study group had their treatment interrupted, one for 3 days and the other for one week due to @entity2335 , while the rest of the @entity1 were able to complete the treatment according to schedule. CONCLUSION: Radiotherapy plus chemotherapy after bladder conservation surgery for muscle invasive @entity150 can decrease the rate of pelvic recurrence effectively and be used as a realistic adjuvant treatment.
