Multiple factors contribute to the pathogenesis of hypertension in XXXX .

@entity1 @entity1369 @entity7199 @entity1421 @entity2178 @entity3371 @entity699 @entity701 @entity916 @entity652 @entity1063
The mechanisms causing high blood pressure in @entity1 with @entity699 were investigated by measurements of humoral factors and pharmacological maneuvers. Twelve @entity1 with @entity652 were studied. The mean systolic and diastolic pressures of the @entity1 were 171 +/- 28 and 109 +/- 15 mm Hg (+/- SEM), respectively, which were significantly higher than those of normal subjects. PRA, plasma @entity916 concentration, plasma @entity916 substrate, plasma @entity701 , plasma @entity1369 , urinary @entity7199 , and urinary @entity1421 were measured as the humoral factors. PC values were markedly elevated in @entity1 with @entity699 . Among the components of the @entity916 -angiotensin system, only plasma @entity916 substrate was increased. Urinary kallikrein and @entity1421 were decreased in @entity1 with @entity699 . Oral administration of @entity3371 lowered blood pressure, but infusion of an @entity2178 analog did not. Furthermore, the pressor responses to infusion of both @entity1063 and @entity2178 were increased. We conclude that blood pressure is elevated in @entity1 with @entity699 because they have enhanced pressor responses to vasoactive substances, suppression of depressor systems, and some abnormalities of the @entity916 -angiotensin system.
