[French first results using magnetic resonance-guided focused ultrasound for XXXX treatment].

@entity1 @entity1416 @entity177 @entity1868 @entity2909
OBJECTIVE: Many @entity1 with @entity1868 desire uterine conservation. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a new non-invasive therapy. We describe our early results regarding efficacy and safety of MRgFUS for the treatment of uterine @entity2909 . @entity1 AND METHODS: Fifty-two French @entity1 , over 18 years of age, who were candidates for surgical myomectomy, @entity1416 due to symptomatic @entity1868 were treated by MRgFUS (ExAblate 2000(  ), InSightec) and followed up for at least 6 months. Intramural or @entity1868 with a size between 4-12 cm and a T2 low intensity MRI image were selected in @entity1 with no abdominal scar and no bowel interposition. The modified symptom severity score (SSS) was examined before and after the treatment at 6 months. Second treatment rate during the first follow-up year was reported. RESULTS: No serious complications were recorded during the treatments or follow-up period. Seven @entity1 had @entity177 mostly because of bowel interposition, six of them had uterine artery embolisation. The mean modified SSS value for @entity1 before MRgFUS was 41/100 and the values diminished significantly to a mean value of 22/100. A total of 65% of @entity1 had a reduction of at least 10 points (n=22) (initial score of 41 [29; 62] and 22 [16; 46] at 6 month follow-up). Good correlation was observed between @entity1868 destruction and the symptoms score. During the follow-up period, ten @entity1 (19%) required invasive interventions (six hysterectomies, two embolisations and two myomectomies). The average reduction in @entity1868 volume determined by MR imaging at 6 months after treatment was 14%. This volume reduction is poorly correlated with the @entity1868 's treated volume of 36.4% (6-74%). CONCLUSION: MRgFUS can safely be used for symptomatic treatment and avoid the need for surgical intervention in most @entity1 . Additional follow-up is needed to determine the long-term durability of this promising non-invasive approach and to obtain reimbursement.
