Association of XXXX with pemphigus.

@entity1 @entity4107 @entity7271
HLA typing for the A, B, C, and D locus antigens was performed on 65 @entity1 with @entity7271 and on 558 controls living in the Los Angeles area. The @entity1 were divided into several categories. These included Jewish and non-Jewish @entity1 , @entity1 with only mucous membrane involvement, only skin or both mucous membrane and skin involvement, and those with a single-episode or recurrent disease. Depending on the highest titer of anti-intercellular cement substance antibody titer, the @entity1 were categorized into those whose titers were 0-80, 160-320, and 640 or greater. A statistically increased incidence of HLA-A25, HLA-B38, and HLA- @entity4107 antigens was observed in @entity1 compared to controls. This incidence was significantly higher in Jewish compared to non-Jewish @entity1 . The correlations were insignificant in the group with an antibody titer of 0-80, but significant in those with a titer of 160-320, and even more significant in those with titers greater than 640. No significant differences were present between @entity1 who had a single-episode or recurrent disease or in those that had only mouth or only skin involvement. In all categories tested, the association was stronger with @entity4107 than with A26 or B38. @entity4107 was present equally in B38-positive and B38-negative @entity1 . The primary association of @entity7271 may be with the @entity4107 antigen, and it may be a marker for the severity of the disease.
