Spinal facilitation in cholinergic-sympathetic efferents by XXXX .

@entity1 @entity3160 @entity5829 @entity146 @entity2661 @entity841 @entity2922 @entity3159 @entity468
@entity841 ( @entity841 ) evoked by electrical stimulation of the cholinergic-sympathetic system at different levels were recorded in the forepaws of anaesthetized @entity468 and used as a measure of sudomotor activity. After pretreatment with @entity3160 (0.25 mg/kg i.v.) to block alpha 2-adrenoceptors, unilateral electrical stimulation of the hypothalamus (square wave pulses 1 ms duration, 16 Hz, 2 s train length at intervals of 1 min) induced @entity841 in both forepaws. Injection of the inhibitor of neuronal @entity2922 reuptake, @entity5829 (1 mg/kg i.v.), facilitated the @entity841 in both forepaws, even though access of the drug to the sweat glands was prevented by application of a tourniquet to one paw. The facilitation was abolished by injection of the specific alpha 1-adrenoceptor antagonist, @entity3159 (0.5 mg/kg i.v.). An equal enhancement of this effect by @entity5829 (1 mg/kg i.v.) and its abolition by @entity3159 (0.5 mg/kg i.v.) was obtained in @entity468 with the brain stem transected at the level of the medulla oblongata and electrical stimulation of the spinal cord at C1. @entity841 evoked in the right forepaw by preganglionic electrical stimulation of the right stellate ganglion were inhibited by @entity5829 (1 mg/kg i.v.). From these and previous results it is concluded that inhibition of neuronal reuptake of @entity2661 results in facilitation of activity in sudomotor efferents. This effect is mediated by spinal alpha 1-adrenoceptors and provides an explanation of the occasional occurrence of excessive sweating in @entity146 @entity1 treated with tricyclic antidepressants.
