Increased risk of XXXX with higher antenatal maternal altitude.

@entity1 @entity8213 @entity2222 @entity600 @entity91
BACKGROUND: During the 1980s, the Colorado Department of Health received reports from several high-altitude communities of clusters of the @entity600 . In a population-based, case-control study, we examined the association between overall and trimester-specific maternal antenatal altitude exposure and the occurrence of @entity1 @entity91 . METHODS: We identified case @entity1 through a statewide registry and randomly sampled control @entity1 from birth records. By telephone interview, each mother provided data on the locations of all antenatal residences and places of employment as well as other factors. Staff mapped all locations and abstracted the corresponding altitudes. RESULTS: The odds ratio (OR) of any @entity8213 for a time-weighted mean antenatal altitude of > or = 2000 metres (high altitude) versus < 2000 metres (low altitude) was 1.4 (lower bound of the one-sided 95% test-based confidence interval (CI): 0.9). The OR was elevated in smokers but not in non-smokers. As compared to non-smokers, the OR of any @entity8213 for @entity2222 was 4.6 (lower bound of the 95% one-sided exact CI: 1.7). Particularly elevated were the corresponding OR of coronal (18.1, 4.4) and @entity91 (16.3, 2.8), and OR for high-altitude exposure during the second trimester (any @entity8213 : 6.4, 1.99; coronal: 28.6, 6.1; metopic: 26.7, 4.1). CONCLUSIONS: Antenatal maternal high-altitude exposure and smoking are associated with increased risk of @entity1 @entity91 , perhaps through generation of intermittent hypoxaemia.
