Mechanism of inhibition of mitochondrial enzymatic complex I-III by XXXX derivatives.

@entity632 @entity291 @entity6894
We demonstrate here that complex I-III of @entity291 heart mitochondrial membrane is inhibited by @entity632 derivatives. This inhibition is a @entity6894 -dependent process. This lipid, specific to the inner mitochondrial membrane, has been shown previously to interact specifically with @entity632 in model membranes (Goormaghtigh, E., Chatelain, P., Caspers, J. and Ruysschaert, J.-M. (1980) Biochim. Biophys. Acta 597, 1-14) and in mitochondrial membranes (Cheneval, D., M  ller, M., Toni, R., Ruetz, S. and Carafoli, E. (1985) J. Biol. Chem. 260, 13003-13007). The differential scanning calorimetry data indicate that, in multilamellar liposomes, the formation of antibiotic- @entity6894 complexes induces a clustering of @entity6894 molecules. Conformational analysis of the antibiotic- @entity6894 complexes suggests that plane-plane interactions between the antibiotics aromatic moieties stabilize this complex formation. Possible mechanisms of inactivation of complex I-III by @entity632 are proposed.
