Does ground glass opacity-dominant feature have a prognostic significance even in clinical T2aN0M0 XXXX ?

@entity1 @entity5 @entity3 @entity420 @entity2220
INTRODUCTION: Recent studies have demonstrated that ground glass opacity (GGO)-dominant @entity5 correspond to pathologically low-grade @entity420 and that @entity1 with resected @entity5 have an excellent prognosis. However, almost all of those studies were limited to @entity5 measuring  <=3.0cm. The purpose of this study was to characterize lung @entity420 >3.0cm in diameter with GGO-dominant features and evaluate the prognosis of @entity1 with such @entity5 . METHODS: One hundred and thirteen @entity1 with cT2aN0M0 @entity2220 underwent surgical resection between 2005 and 2011. Twenty-five had @entity5 with a >= 50% GGO component (GGO-dominant group) and the remaining had solid-dominant @entity5 (Solid-dominant group). The clinicopathological findings and prognosis of the two groups were evaluated. RESULTS: The @entity5 in the GGO-dominant group rarely exhibited pathological invasiveness, such as lymphatic (n=1), vascular (n=0) and @entity3 (n=5) or lymph node @entity3 (n=0). On the other hand, the @entity5 in the solid-dominant group frequently exhibited pathological invasiveness, including lymphatic (n=26), vascular (n=16) and plural invasion (n=52) and lymph node @entity3 (n=18). There were significant differences in all of the characteristics between the two groups (lymphatic; p=0.0026, vascular; p=0.0214, and @entity3 ; p=0.0004, and lymph node metastases; p=0.0086, respectively). In the GGO-dominant group, 24 @entity1 were alive without recurrence, while the remaining died of another @entity5 . Recurrence occurred in 34 @entity1 in the solid-dominant group, and 16 died of the disease. The 5-year survival rate was 96% in the GGO-dominant group, compared to 71% in the solid-dominant group (p=0.0120). CONCLUSIONS: In the GGO-dominant group, the malignant potential was low and the @entity1 had a favorable prognosis after surgery, similar to the @entity1 with GGO-dominant @entity5 diagnosed as cT1a-bN0M0.
