The age factor for @entity2664 's XXXX : Multiple doses render the adult @entity19 heart more susceptible to injury.

@entity1 @entity137 @entity19 @entity908 @entity2664 @entity2041 @entity492 @entity1500 @entity493 @entity299 @entity1370
UNASSIGNED: Age is a known susceptibility factor for the @entity1370 of several anticancer drugs, including @entity2664 ( @entity1500 ). The impact of anticancer drugs in young @entity1 is underestimated, thus we aimed to evaluate the @entity1370 of @entity1500 in juvenile and adult animals. Juvenile (3 week-old) and adult (8-10 week-old) male CD-1 @entity19 were used. Each group was treated with a 9.0mg/kg cumulative dose of @entity1500 or saline; they were maintained in a drug-free period for 3-weeks after the last administration to allow the development of late @entity137 (protocol 1), or sacrificed 24h after the last @entity1500 administration to evaluate early @entity1370 (protocol 2). In protocol 1, no adult @entity19 survived, while 2 of the juveniles reached the end of the protocol. High plasma @entity492 aminotransferase/ @entity493 aminotransferase ratio and a high cardiac reduced/oxidized @entity2041 ratio were found in the surviving @entity1500 -treated juvenile @entity19 . In protocol 2, a significant decrease in plasma @entity908 -kinase MB in juveniles was found 24h after the last @entity1500 -administration. Cardiac histology showed that both @entity1500 -treated populations had significant damage, although higher in adults. However, @entity1500 -treated juveniles had a significant increase in fibrotic tissue. The @entity1500 -treated adults had higher values of cardiac GSSG and protein carbonylation, but lower cardiac noradrenaline levels. For the first time, mature adult animals were shown to be more susceptible to @entity1500 as evidenced by several biomarkers, while young animals appear to better adjust to the @entity1500 -induced @entity299 . Even so, the higher level of fibrotic tissue and the histological damage showed that @entity1500 also causes @entity299 in the juvenile population.
