XXXX : high resolution nerve-sparing radical hysterectomy based on developmentally defined surgical anatomy.

@entity1 @entity66 @entity5 @entity189 @entity348
@entity348 ( @entity348 ) is characterized by: i). the en bloc resection of the uterus, proximal vagina, and mesometrium as a developmentally defined entity; ii). transection of the rectouterine dense subperitoneal connective tissue above the level of the exposed inferior hypogastric plexus; and iii). extended pelvic/periaortic lymph node dissection preserving the superior hypogastric plexus. Since July 1998 we have studied prospectively the outcome in @entity1 treated with @entity348 for cervical @entity189 FIGO stages IB, IIA, and selected IIB. By July 2002, 71 @entity1 with @entity5 stages pT1b1 (n = 48), pT1b2 (n = 8), pT2a (n = 3), pT2b (n = 12) had undergone @entity348 without adjuvant radiation. Fifty-four percent of the @entity1 exhibited histopathologic high risk factors. At a median observation period of 30 months (9-57 months) two @entity1 relapsed locally, two @entity1 developed pelvic and distant recurrences and two @entity1 only distant recurrences. Three @entity1 died from their disease. Grade 1 and 2 complications occurred in 20 @entity1 , no @entity1 had grade 3 or 4 complications. No severe long-term impairment of pelvic visceral functions related to @entity66 was detected. Based on these preliminary results, we believe @entity348 achieves a promising therapeutic index by providing a high probability of locoregional control at minimal short and long-term morbidity.
