Analysis of a Functional @entity650 Gene Polymorphism in XXXX Associated and Intermediate @entity1596 Gives New Insight in Disease Pathogenesis and Commonality with Other @entity792 .

@entity1 @entity650 @entity1530 @entity1596 @entity5502 @entity15 @entity15147 @entity792
Purpose. @entity650 ( @entity650 ) plays a crucial role in both adaptive and innate immunity. The @entity15147 gene polymorphism of @entity650 is associated with various @entity792 , like @entity15 . Methods. 134 @entity1 with @entity1530 positive @entity5502 , 84 @entity1 with intermediate @entity1596 , 132 controls, and 65 @entity1530 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for @entity15147 was significantly higher in @entity1 with intermediate @entity1596 compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for @entity15147 did not differ significantly in @entity1 with @entity1530 associated @entity1596 when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between @entity15 and intermediate @entity1596 . Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.
