[Accelerated fractionated radiotherapy with concurrent chemotherapy in advanced XXXX ].

@entity1 @entity900 @entity189 @entity1577 @entity1487
BACKGROUND _ OBJECTIVE: Clinical studies showed there is no satisfying treatment efficacy of the @entity1 with advanced @entity189 ( @entity189 ) using conventional fractionated radiotherapy. It is important to treat the @entity1 with advanced @entity189 using different fractionated radiotherapy and radiotherapy combined with chemotherapy. The current study was designed to evaluate the efficacy and radiation reactions of accelerated fractionated radiotherapy with concurrent chemotherapy for advanced @entity189 @entity1 . METHODS: From June 1993 to June 1996, 416 @entity1 pathologically confirmed @entity189 who firstly underwent radiotherapy were divided into three groups: accelerated fractionated radiotherapy group (AF group, n=138, 6 fractions per week, one time per day, 180-190 cGy per day to a total dose of 7,400-7,600 cGy). Accelerated fractionated radiotherapy with concurrent chemotherapy group (AFC group, n=139, 6 fractions per week, one time per day, 180-190 cGy per day to a total dose of 7,400-7,600 cGy, @entity900 and @entity1487 one time per week) and conventional fractionated radiotherapy group ( @entity1577 group, n=139, 5 fractions per week, one time per day, 200 cGy per day to a total dose of 7,000-7,600 cGy). The local recurrent rate, 5-year survival rate, and acute radiation reactions in the three groups were observed. RESULTS: All @entity1 were followed up for more than 5 years. The local recurrent rates in AF group (16.7%) and AFC group (13.6%) were lower than that in @entity1577 group (27.3%)(P< 0.05). The 5-year survival rates in AF group (53.6%) and AFC group (57.6%) were higher than that in @entity1577 group (43.8%)(P< 0.05). The acute radiation reactions in AF group (47.1%) and AFC group (51.1%) were higher than that in @entity1577 group (33.8%)(P< 0.05). CONCLUSION: AF and AFC schedules are feasible in reducing local recurrent rate and enhancing 5-year survival rate for @entity1 with advanced @entity189 . The acute radiation reactions of the AF and AFC groups are tolerable.
