The role of @entity3775 in the development of XXXX in the @entity35 .

@entity3775 @entity2741 @entity1391 @entity460 @entity35 @entity4727
The present study evaluates the effect of an intravenous (i.v.) @entity3775 infusion on total and ionized @entity460 . Seven groups of @entity35 were studied, and it was found that the magnitude of @entity2741 was dose dependent. During a two hour i.v. infusion containing 0.4 mg @entity3775 per 100 grams of body weight, the total plasma @entity460 increased from 9.7 +/- 0.2 to 12.7 +/- 0.7 mg/dl (X +/- SE, P less than 0.02) while the ionized @entity460 decreased from 5.1 +/- 0.12 to 4.05 +/- 0.24 mg/dl (P less than 0.001). The increase in plasma @entity460 occurred in intact and parathyroidectomized @entity35 , and the @entity2741 could not be attributed to changes in @entity4727 , arterial pH, plasma protein, or plasma @entity1391 . In vitro studies indicate that the addition of @entity3775 to @entity35 plasma results in decreased ionized @entity460 concentration. Similarly, ultrafilterable @entity460 declined from 5.4 +/- 0.17 to 4.53 +/- 0.12 mg/dl (P less than 0.001) after the addition of @entity3775 to @entity35 plasma. In summary, high levels of intravenous @entity3775 increase total plasma @entity460 and decrease ionized @entity460 . As also supported by in vitro data, the most probable mechanism is increased binding of @entity460 in the plasma which decreases ionized @entity460 . As a result of the decreased concentration of ionized @entity460 , movement of bone and interstitial @entity460 into the vascular space may occur, thus increasing total plasma @entity460 .
