XXXX activity of the ethanol extract of Pavetta crassipes leaves.

@entity1169 @entity101 @entity5521 @entity8765 @entity3044 @entity1576 @entity3897 @entity750 @entity35 @entity1063 @entity468 @entity551 @entity4338
Pavetta crassipes leaf is routinely used locally in Nigeria for the management of @entity1576 and @entity101 . The @entity551 and other cardiovascular effects of Pavetta crassipes were investigated in @entity468 and @entity35 . The effects of the extract on @entity35 and cat blood pressures, isolated @entity35 atria, @entity35 portal vein, isolated @entity35 aorta and @entity35 vas deferens were studied. Specific receptor antagonists ( @entity3897 , @entity8765 , @entity5521 , @entity1169 ) were used to elucidate the underlying mechanism(s) involved in the cardiovascular changes induced by P. crassipes. The results revealed that the ethanolic extract of Pavetta crassipes lowered the blood pressures of @entity468 and @entity35 in a dose dependent manner. The extract also caused a concentration-dependent decrease in the force of contraction of the isolated @entity35 atria and @entity35 portal vein. The decreases in blood pressure values were attenuated in the presence of a beta-adrenoceptor antagonist, @entity1169 . The extract also attenuated @entity3044 -induced contraction of the @entity35 atria. However, the extract did not affect contractions evoked by @entity4338 , @entity1063 and @entity750 on the @entity35 aorta. Pavetta crassipes contains biologically active substances that may be useful in the management of @entity101 .
