[Effectiveness of @entity24819 therapy on colonic motility disorders in XXXX ].

@entity1 @entity294 @entity24819 @entity490 @entity1142 @entity1744
The special patterns of the slow wave activity in irrittable bowel syndrome by means of surface electromyography were examined and the effect of @entity24819 on the symptoms and on the colonic motility in this disease was estimated. Twenty two @entity1 with @entity1744 and 7 healthy controls were selected to the study. The clinical symptoms were @entity490 and bloating in all @entity1 , @entity1142 in 9, and @entity294 in 6 cases. Surface electromyography was carried out before and on the 14th day of the treatment with @entity24819 (50 mg t. i. d). The colonic motility was analysed in a 2 hour fasting and a 2 hour postprandial period following a standard (800 kCal) meal. The slow wave frequency of 0.01-0.04 Hz were selected and analysed. The mean frequency of activity peaks (n/10 min) and power-index (area under curve, microV 10 min) were measured. For statistical analysis Student's t-test was applied. Electromyogram of @entity1 with @entity1744 showed a significant increase of the measured colonic motility parameters both in fasting and postprandial states. Fourteen days of @entity24819 treatment was able to significantly reduce the intensity of the colonic motor activity. Administration of @entity24819 completely released in 6 and significantly improved the @entity490 in other 12 @entity1 , while the bloating disappeared in 12 and was significantly improved in 5 from 22 @entity1 . @entity24819 was able to normalise the stool frequency: the weekly number of stools was decreased from 16 to 7 in the @entity1 complaining @entity294 ant it was increased from 2 to 6 in the @entity1 with @entity1142 .
