Expression and Clinical Significance of microRNA-1246 in @entity1 XXXX .

@entity5 @entity1 @entity957 @entity4221
Background MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or @entity5 suppressors. Previous studies have shown that the expression level of @entity4221 was enhanced in multiple types of @entity5 . However, the expression of @entity4221 in @entity1 @entity957 ( @entity957 ) and its prognostic values remain unclear. Material and Methods Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to analyze the expression of @entity4221 in 106 pairs of matched normal and @entity5 tissue samples. The chi-square test was used to examine the associations between @entity4221 expression and the clinicopathological characters. The survival curves were constructed by the Kaplan-Meier method. The influence of each clinical variable on survival was examined by the Cox multivariate regression analysis. Results The expression level of @entity4221 was significantly higher in @entity5 tissues and @entity5 cell lines than in normal controls (p<0.01). High expression of @entity4221 was found to significantly correlate with nodal status (p=0.015), TNM stage (p=0.005), and @entity5 grade (p=0.002). Enhanced @entity4221 correlated significantly with @entity1 survival (p<0.01). In multivariate analysis, we found that @entity4221 expression was an independent prognostic factor of poor @entity1 survival (p= 0.036; HR=2.82; 95% CI=1.07-7.43). Conclusions High @entity4221 expression is associated with poor prognosis in @entity957 and may serve as a novel prognostic marker in @entity957 .
