XXXX therapy for poor-responders during IVF: a prospective controlled observational trial.

@entity1 @entity1501 @entity8580 @entity53
BACKGROUND: The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24  %. The management of these @entity1 remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate the effect of @entity8580 (MI) on ovarian function in poor responders undergoing ICSI. METHODS: The study is a prospective controlled observational trial, that involved 72 poor responders included in an ICSI program and divided into two groups; group A: 38 @entity1 who have been assuming MI (4  g)   +   @entity1501 (FA) (400   g) for the previous 3  months before the enrollment day; group B: 38 @entity1 assuming FA (400   g) alone for the same period. COH was carried out in the same manner in the two groups. The main goal was the assessment of oocytes retrieved number and quality; secondary endpoints were the Ovarian Sensitivity Index (OSI: n   oocytes retrieved/total Gonadotropins units   *   1000), @entity53 levels on the day of hGC, fertilization rate, implantation rate, ongoing pregnancy rate. RESULTS: There was no significant difference between the two groups regarding @entity53 level, but total rec-FSH units were significantly lower (p   =   0.004) and M2 oocytes rate significantly higer (p   =   0.01) in group A. The ovarian sensitivity index was higher, reaching a statistical significance (p   <   0.05), in the group of @entity1 pre-treated with MI, showing an improvement in ovarian sensibility to gonadotropin. CONCLUSIONS: Our results suggest that MI therapy in poor responders results in an increased of the number of oocytes recovered in MII and of the gonadotropin Ovarian Sensitivity Index (OSI), suggesting a MI role in improving ovarian response to gonadotropins. Therefore MI seems to be helpful in "poor responders" undergoing IVF cycles.
