Autologous recovery following non-myeloablative unrelated donor bone marrow transplantation for severe XXXX .

@entity1 @entity2150 @entity786 @entity205 @entity7965 @entity348 @entity2132
We report the outcome of nine unrelated bone marrow transplants performed for acquired severe @entity2150 at a single centre. Six @entity1 received transplants from fully matched donors. Three donor/recipient pairs were mismatched, two at a single allele on high resolution typing. Pre-transplant conditioning consisted of @entity786 and in vivo Campath-1 monoclonal antibody. One @entity1 also received @entity348 ( @entity348 ), and another @entity1 with a coexisting @entity7965 ( @entity7965 ) clone received additional busulphan. @entity205 was given for 12 months as prophylaxis against @entity2132 ( @entity2132 ). Six of nine @entity1 are alive and transfusion independent with a mean follow-up of 24 months (range: 1.5-94). All six @entity1 who received fully matched transplants are alive; the three who received mismatched grafts died. Four long-term survivors developed autologous haematological recovery following rejection of their grafts. Acute @entity2132 grade II+ occurred in two @entity1 . We highlight the importance of high-resolution HLA typing, including Cw matching in reducing the incidence of graft rejection and @entity2132 , resulting in improved survival in our @entity1 group. This study also shows that autologous recovery with long-term survival can occur following non-irradiation conditioning regimens.
