XXXX genetic polymorphisms is associated with improvement of health-related quality of life in Chinese population with @entity1252 .

@entity1 @entity4738 @entity72104 @entity1252 @entity72101 @entity72099 @entity49136 @entity72103 @entity72102 @entity72100 @entity158 @entity4334
UNASSIGNED: In our previous study, we found that @entity4738 ( @entity4738 ) gene genetic polymorphisms may play a major role in the efficacy of glucocorticoids (GCs) in Chinese @entity1252 ( @entity1252 ) @entity1 . The aim of this study is to explore the association of @entity4738 gene genetic polymorphisms and improvement of health-related quality of life (HRQOL) in Chinese @entity1252 @entity1 treated with GCs. A total of 195 Chinese @entity1252 @entity1 were treated with GCs for 12  weeks. The HRQOL of @entity1 was measured with the Medical Outcomes Study Short Form-36 (SF-36) at baseline and 12  weeks. Polymorphisms of @entity4738 gene were genotyped by using multiplex SNaPshot method. One hundred eighty-four @entity1 (94.36  %) completed the 12-week follow-up. Twenty-three single- @entity4334 polymorphisms of @entity4738 gene were genotyped. There was a significant association between @entity72099 polymorphism and improvement in physical function (P   =   0.043), general health (P   =   0.024), and social function (P   =   0.013). The @entity72100 polymorphism was associated with improvement in the total score of SF-36 (P   =   0.014), physical function (P   =   0.013), general health (P   =   0.010), vitality (P   =   0.015), social function (P   =   0.004), physical component summary (P   =   0.016), and mental component summary (P   =   0.014). The @entity49136 polymorphism was associated with improvement in bodily @entity158 (P   =   0.040) and general health (P   =   0.038). The @entity72101 polymorphism was associated with improvement in general health (P   =   0.026) and vitality (P   =   0.027). The @entity72102 polymorphism was associated with improvement in bodily @entity158 (P   =   0.034). The @entity72103 polymorphism was associated with improvement in vitality (P   =   0.002) and mental component summary (P   =   0.041). We also found a significant association between @entity72104 polymorphism and improvement in physical function (P   =   0.040), bodily @entity158 (P   =   0.007), and general health (P   =   0.019). These results indicate that there may be an association of @entity4738 gene @entity72099 , @entity72100 , @entity49136 , @entity72101 , @entity72102 , @entity72103 , and @entity72104 polymorphisms with improvement of HRQOL in Chinese @entity1252 @entity1 treated with GCs.
