[Dynamic study on relationship between serum SEAIC level and hepatic pathological changes in XXXX infected with Schistosoma japonicum].

@entity19 @entity738 @entity1885 @entity2040
Using purified rabbit polyclonal antibodies to SEA, avidin- @entity1885 system and capture ELISA technique, we observed the dynamic changes in the level of the circulating soluble egg antigen-antibody complex (SEAIC) in @entity19 sera at various weeks post infection. Simultaneously, the diameter and area of liver egg @entity738 were measured by using profile analytical technique. Serum SEAIC was first detected 4 weeks post infection (p.i.), reaching peak level at 6-7th week, and then gradually dropped, and maintained at moderately high level till the end of the observation (12 weeks p.i.). Schistosome eggs appeared in liver tissue at 4 weeks p.i. No egg @entity738 could be found until 6 weeks p.i. The peak of the average diameter and area of liver egg @entity738 was noted at 7 weeks p.i., then dropped gradually. Its dynamic changes were consistent with that of the serum SEAIC level. It is therefore suggested that the serum SEAIC level could be a reference index reflecting the extent of the pathological changes of the liver. Moreover, SEAIC might play an important role in the pathogenesis of @entity2040 japonica.
