Mechanism of XXXX : New evidence challenging the prevailing theory.

@entity1 @entity8 @entity82 @entity13187 @entity27307 @entity810 @entity5777 @entity2287
@entity13187 ( @entity13187 ) has been associated with the administration of @entity2287 -based contrast agents in @entity1 with @entity8 ( @entity8 ), @entity8 ( @entity8 ), or @entity810 ( @entity810 ). Since the vast majority of these @entity1 do not get @entity13187 , it is highly likely that @entity1 factors play a role in its development. Although "free" or dechelated @entity2287 is thought by some to be the only trigger of @entity13187 , recent evidence suggests that chelated @entity2287 may be important. Chelated @entity2287 such as Omniscan ( @entity5777 ) and Magnevist ( @entity27307 ) can directly stimulate macrophages and monocytes in vitro to release profibrotic cytokines and growth factors capable of initiating and supporting the tissue @entity82 that is characteristic of @entity13187 . In addition, an effect of chelated @entity2287 on fibroblasts has also been demonstrated. Chelated @entity2287 in the form of Omniscan, Magnevist, MultiHance, and ProHance increased proliferation of @entity1 dermal fibroblasts. Indeed, increased numbers of macrophages, together with activated fibroblasts and fibrocytes, are essential cells in the fibrotic process and are present in @entity13187 skin. Accordingly, it is important that chelated @entity2287 , in combination with @entity1 cofactors, is considered in the etiology of @entity13187 associated with enhanced scans. J. Magn. Reson. Imaging 2009;30:1277-1283. (c) 2009 Wiley-Liss, Inc.
