Incidence and prognostic significance of non-enhancing cortical signal abnormality in XXXX .

@entity1 @entity463
INTRODUCTION: The presence of non-enhancing cortical signal abnormality is useful for differentiating between @entity463 and metastatic disease, but its significance has not been studied. We aimed to determine the incidence and prognostic implications of non-enhancing cortical signal abnormality in @entity463 . METHODS: @entity1 with a new diagnosis of @entity463 between September 2007 and December 2010 were identified. Only @entity1 with at least fluid-attenuated inversion recovery (FLAIR) and post-contrast T1-weighted sequences were included. Pre-operative MRIs were reviewed together by two readers to determine whether there was evidence of non-enhancing cortical signal abnormality, based primarily on the FLAIR sequence. The results were compared with @entity1 survival using both univariate and multivariate analysis. RESULTS: One hundred fifty-one @entity1 met the inclusion criteria. Seventy-seven @entity1 (51%) had evidence of non-enhancing cortical signal abnormality. On both univariate and multivariate analysis, there was overall no significant difference in survival between @entity1 with non-enhancing cortical signal abnormality and those without. Peripheral enhancing lesions (51 @entity1 ) were generally associated with the longest survival, but subgroup analysis suggested that non-enhancing signal abnormality was associated with worse survival in these @entity1 (P   =   0.004), conveying an intermediate prognosis. CONCLUSIONS: Non-enhancing cortical signal abnormality is a common feature of @entity463 , occurring in about half of cases. It does not affect survival overall, but appears to be associated with worse survival in the setting of a peripherally located enhancing lesion. This has the potential to alter surgical management.
