The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related @entity4578 and XXXX , so-called Mikulicz's disease.

@entity1 @entity7841 @entity75 @entity5 @entity2103 @entity1892 @entity244 @entity4578
IgG4-related @entity4578 and @entity7841 (IgG4-DS) is characterized by serum IgG4 elevation and the infiltration of IgG4-positive plasma cells in glandular tissues. For definitive diagnosis of IgG4-DS, biopsies of @entity75 are recommended to exclude @entity244 ( @entity244 ), @entity5 , and similar disorders. In this study, we examined the diagnostic utility of submandibular gland (SMG) and labial salivary gland (LSG) biopsies in IgG4-DS. Fourteen @entity1 presenting with swelling of the SMG (eight females and six males) underwent both SMG and LSG biopsies. The sensitivity, specificity, and accuracy of SMG biopsies were all 100.0%. In contrast, those of LSG biopsies were 69.2%, 100.0%, and 71.4%, respectively. Thirty-three out of 61 LSG biopsies (54.1%) from all 14 @entity1 were positive for the diagnostic criteria of IgG4-DS (IgG4-positive/IgG-positive plasma cells >0.4). None of the @entity1 experienced complications such as @entity2103 , sialocele, or hyposalivation. The IgG4/IgG ratio showed no significant correlation between the LSG and SMG. The final diagnosis was IgG4-DS in 13 @entity1 and @entity1892 ( @entity1892 ) in one. These results suggest that incisional biopsy of the SMG is useful and appropriate for the definitive diagnosis of IgG4-DS, while diagnosis by LSG biopsy alone requires more caution.
