Novel risk scores for survival and intracranial failure in XXXX treated with radiosurgery alone to @entity320 brain @entity3 .

@entity1 @entity75 @entity3987 @entity3 @entity85 @entity320 @entity1349
PURPOSE: Stereotactic radiosurgery (SRS) alone is an increasingly common treatment strategy for brain @entity3 . However, existing prognostic tools for @entity1349 ( @entity1349 ) were developed using cohorts of @entity1 treated predominantly with approaches other than SRS alone. Therefore, we devised novel risk scores for @entity1349 and @entity75 ( @entity75 ) for @entity320 brain @entity3 (MBM) treated with SRS alone. METHODS AND MATERIALS: We retrospectively reviewed 86 @entity1 treated with SRS alone for MBM from 2009-2014. @entity1349 and @entity75 were estimated using the Kaplan-Meier method. Cox proportional hazards modeling identified clinical risk factors. Risk scores were created based on weighted regression coefficients. @entity1349 scores range from 0-10 (0 representing @entity3987 ), and @entity75 risk scores range from 0-5 (0 representing lowest risk of @entity75 ). Predictive power was evaluated using c-index statistics. Bootstrapping with 200 resamples tested model stability. RESULTS: The median @entity1349 was 8.1  months from SRS, and 54 (70.1  %) @entity1 had @entity75 at a median of 3.3  months. Risk scores for @entity1349 were predicated on performance status, @entity85 ( @entity85 ) status, number of lesions, and gender. Median @entity1349 for the low-risk group (0-3 points) was not reached. For the moderate-risk (4-6 points) and high-risk (6.5-10) groups, median @entity1349 was 7.6  months and 2.4  months, respectively (p   <   .0001). Scores for @entity75 were predicated on performance status, @entity85 status, and number of lesions. Median time to @entity75 for the low-risk group (0 points) was not reached. For the moderate-risk (1-2 points) and high-risk (3-5 points) groups, time to @entity75 was 4.8 and 2.0  months, respectively (p   <   .0001). The novel scores were more predictive (c-index   =   0.72) than @entity320 -specific graded prognostic assessment or RTOG recursive partitioning analysis tools (c-index   =   0.66 and 0.57, respectively). CONCLUSIONS: We devised novel risk scores for MBM treated with SRS alone. These scores have implications for prognosis and treatment strategy selection (SRS versus whole-brain radiotherapy).
