Regulation of @entity72049 Expression by @entity16404 - XXXX - @entity10433 Signaling Pathway.

@entity32 @entity16404 @entity8837 @entity19 @entity10433 @entity8932 @entity72049
UNASSIGNED: @entity8932 ( @entity8932 )-mediated signaling cascades and gene regulation are mainly involved in diseases such as immunity and @entity32 . In this study microarray analysis was performed using bone marrow-derived macrophages (BMDM) and Raw 264.7 cells to identify novel proteins involved in the @entity8932 -mediated cellular response. We found that pleckstrin homology-like domain family, member 1 ( @entity72049 ) is a novel gene up-regulated by @entity8932 stimulation and determined the unique signaling pathway for its expression. Treatment with @entity8932 agonist Pam3 CSK4 increased mRNA, protein, and fluorescence staining of @entity72049 . Induction of @entity72049 by @entity8932 stimulation disappeared from @entity8932 KO @entity19 -derived BMDM. Among janus kinase (JAK) family members, @entity16404 was involved in @entity8932 -stimulated @entity72049 expression. @entity10433 ( @entity10433 ) also participated in @entity72049 expression downstream of the @entity16404 . Interestingly, @entity8837 was an intermediate between @entity16404 and @entity10433 . In silico analysis revealed the presence of highly conserved y-activated sites within @entity19 @entity72049 promoter and confirmed the @entity16404 - @entity10433 pathway is important to Pam3 CSK4 -induced @entity72049 transcription. These findings suggest that the @entity16404 - @entity8837 - @entity10433 pathway is an important signaling pathway for @entity72049 expression and that these proteins may play a critical role in eliciting @entity8932 -mediated immune and inflammatory response. This article is protected by copyright. All rights reserved.
