Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to @entity2690 Resistance and XXXX .

@entity1 @entity32 @entity296 @entity28 @entity2690 @entity1254 @entity65 @entity1851
UNASSIGNED: @entity2690 resistance (IR) and @entity32 are associated with an increased risk of @entity65 and may contribute to @entity296 . The earliest sign of @entity296 is impaired left ventricular (LV) diastolic function, which may be evident in @entity28 @entity1 and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and @entity28 and to assess the relative individual contributions of adiposity, IR, and @entity32 to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0    0.8; non-IR n  = 19, IR n  = 16) and 34 non-OW youth (body mass index standard deviation score 0.1    0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p  = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment- @entity2690 resistance and @entity1851 were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. @entity1254 was a negative determinant of LV-IVS, independent of @entity28 . In conclusion, OW youth with IR and @entity32 are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature @entity65 in adulthood.
