Regional myocardial function during contiguous ischaemia in an anaesthetized XXXX model: comparison of six methods of measurement.

@entity296 @entity455 @entity64 @entity1508 @entity308 @entity235 @entity1347 @entity26 @entity1425 @entity935 @entity5161 @entity2661 @entity1063 @entity3575
During @entity296 , the function of the unaffected muscle is the primary determinant of residual cardiac performance. We compared six methods of measuring regional function in the remaining non-ischaemic segment after acute ligation of the @entity1347 ( @entity1347 ) coronary artery in 16 @entity235 . Preparation included left ventricular micromanometers, regional sonomicrometer transducers to measure segment length and wall thickness, caval occluders and left atrial catheters for injection of radioactive microspheres to measure regional blood flow. Pulmonary artery, central @entity455 were measured and regional coronary venous blood was collected for direct myocardial @entity26 consumption (VO2) calculations. Under basal high-dose @entity3575 -neuromuscular blocker anaesthesia, the @entity1347 was occluded after addition of @entity1508 or @entity5161 at 0.5 or 1.5 MAC concentrations. Regional myocardial function of the non-ischaemic segment was assessed by the following computer-derived indices: percent systolic wall thickening (% WT), velocity of shortening (vs), percent systolic shortening (%SS), regional @entity64 work (RSW), regional preload recruitable @entity64 work (RPRSW) and regional end-systolic elastance (Ees). No index demonstrated enhanced function in the non-ischaemic segment after @entity1347 ligation and all monitors, except Ees, were sensitive to @entity308 of function represented by a decrease in values after administration of @entity1508 and @entity5161 (P < 0.05). Ees values increased with the addition of @entity5161 and remained constant with @entity1508 . Circulating concentrations of @entity2661 were unchanged after ischaemia, while inhalation agents caused a decrease in the concentrations of @entity1425 and @entity935 (P < 0.05), but not @entity1063 .(ABSTRACT TRUNCATED AT 250 WORDS)
