Cytogenetic Study and Analysis of Protein Expression in Plasma Cell Myeloma with t(11;14)(q13;q32): Absence of @entity4042 and @entity57431 , and Infrequent Expression of @entity2225 and XXXX .

@entity1 @entity5953 @entity2940 @entity1075 @entity588 @entity2225 @entity4910 @entity57431 @entity1582 @entity4042 @entity876 @entity3053 @entity13221
The t(11;14)(q13;q32) translocation is the most common chromosomal translocation in @entity1582 ( @entity1582 ), but the cytogenetic and immunophenotypic features of @entity1582 with t(11;14)(q13;q32) remain to be fully elucidated. To address the issue, we retrospectively analyzed 21 newly diagnosed @entity1582 @entity1 with the t(11;14)(q13;q32) translocation in our institute. @entity2225 is a B-cell-specific transmembrane protein that is the topic of much focus as a potential target in immunotherapy. We observed a low incidence of @entity2225 expression (2 of 21 @entity1 , 11%), although the expression of @entity2225 was previously reported to be associated with t(11;14)(q13;q32). @entity5953 is an essential transcriptional factor involved in B-cell development and commitment, and is down-regulated upon plasma cell differentiation. We observed one @entity1 (6%) with expression of @entity5953 . The expression of @entity1075 , @entity2940 , and @entity13221 was detected in one (0.7%), nine (60%), and 13 @entity1 (87%), respectively. @entity4910 , @entity3053 , and @entity588 were detected in all @entity1 ; on the other hand, neither @entity4042 nor @entity57431 was detected in any of the evaluated @entity1 . Abnormalities of chromosome 13 were detected in six @entity1 (38%), but deletion of @entity876 was not observed in any of the evaluated @entity1 . Our results suggest the absence of @entity4042 and @entity57431 expression, and infrequent expression of @entity2225 , @entity5953 , and @entity2940 in @entity1582 with t(11;14)(q13;q32), in contrast to the findings of earlier reports. [J Clin Exp Hematop 55(3) : 137-143, 2015].
