The stimulation of glycolysis by previous aerobiosis in XXXX -liver slices.

@entity3363 @entity6546 @entity948 @entity26 @entity880 @entity35 @entity413 @entity2388
1. An investigation has been made on the stimulation of the anaerobic glycolysis by @entity35 -liver slices caused by previous incubation in @entity26 . 2. The stimulation is sustained partly by endogenous @entity3363 and partly by added @entity413 . The effect of @entity413 reaches a maximum at a concentration of 20mm; it is more pronounced when @entity413 is present in the actual glycolytic phase and not during the aerobic preincubation. The conversion of @entity948 and @entity2388 into @entity880 is not affected by the preincubation in @entity26 . 3. The stimulation occurs also when preincubation is carried out in a medium that blocks the action of phosphorylase. 4. Preincubation for 2-3min. at 37 degrees is enough to ensure maximum stimulation. The main effect of the aerobic incubation is on the initial velocity of the anaerobic glycolysis. 5. The stimulation depends on the nutritional state of the animal: it is decreased practically to nil in @entity35 starved overnight. In starved animals glycogen content and basal and stimulated glycolysis decline progressively with the same trend. If starved animals are injected with @entity413 , liver glycogen concentration increases but basal glycolysis remains at a low level; however, the rate of stimulated glycolysis becomes progressively higher and correlates with the amount of liver glycogen. 6. It is suggested that the aerobic preincubation modifies the factors that regulate glycolysis in liver slices at steps above the level of triose @entity6546 .
