Associations of sense of coherence with XXXX and quality of life in @entity29 .

@entity1 @entity308 @entity283 @entity31 @entity1109 @entity458 @entity29 @entity148 @entity30
AIM: To investigate the relationship between sense of coherence, @entity458 and health related quality of life in @entity29 ( @entity29 ). METHODS: This cross-sectional study enrolled a consecutive sample of 147 @entity29 (aged 45.1    14.1 years; 57.1% female) @entity1 recruited from a tertiary gastroenterology service. Sixty-four @entity1 met diagnostic criteria for @entity30 , while eighty-three @entity1 had @entity31 . Socio-demographic data (education, age, race, gender, gross monthly income and marital status), disease-related variables (illness activity, relapse rate in past 2 years, history of surgery and time since diagnosis), sense of coherence (Antonovsky's SOC scale), @entity1109 ( @entity148 and @entity308 Scale) and @entity283 ( @entity283 ; WHOQOL-Bref) were assessed. Hierarchical multiple regression analyses were performed to identify factors that are independently associated with @entity458 and @entity283 in @entity1 with @entity29 and to provide indications for possible moderating or mediating effects. In addition, formal moderation and mediation analyses (Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC, @entity1109 . RESULTS: Lower SOC scores (std beta= -0.504; P < 0.001), female gender (std beta = 0.176; P = 0.021) and White race (std beta = 0.164; P = 0.033) were independently associated with higher levels of @entity308 , while lower levels of SOC (std beta = -0.438; P < 0.001) and higher relapse rate (std beta = 0.161; P = 0.033) were independently associated with more severe @entity148 . A significant interaction between time since diagnosis and SOC was found with regard to the severity of @entity308 or @entity148 , as the interaction term (time since diagnosis X SOC) had beta coefficients of -0.191 (P = 0.009) and -0.172 (P = 0.026), respectively. Lower levels of @entity148 (std beta = -0.369; P < 0.001), higher levels of SOC (std beta = 0.231; P = 0.016) and non-White race (std beta = -0.229; P = 0.006), i.e., mixed-race, which represented the reference category, were independently associated with higher levels of overall @entity283 . @entity148 symptoms were the most potent independent correlate of most aspects of @entity283 . In addition, @entity148 mediated the association between SOC and satisfaction with health, as well as its relationship with physical, mental, and social relations @entity283 . @entity308 also mediated the association between SOC and mental @entity283 . CONCLUSION: Our data indicated that SOC is an important construct, as it influences @entity458 and has significant albeit indirect effects on several @entity283 domains in @entity29 .
