[Thermotherapy for @entity150 in combination with tegafur suppository and XXXX --concentrations of tegafur in the serum and tissues in @entity150 ].

@entity1 @entity1012 @entity5 @entity16229 @entity150 @entity1487
Thermotherapy combined with tegafur ( @entity16229 ) and @entity1012 was performed in 13 @entity1 with @entity150 . The thermotherapy was performed using a closed circulation type of thermotherapeutic apparatus manufactured for this experiment, by way of a 3-way catheter. The flow rate of the perfusate was 150 ml/min at a constant temperature of 43 degrees C. The temperature was monitored at the inlet and outlet catheter of the urethral meatus. The thermotherapy was performed for a 6-hour period once a week. A tegafur 3000-mg suppository was given 2 hours before the thermotherapy, and @entity1012 was added to the perfusate at the time of thermotherapy. No anesthesia was used. @entity5 was observed in 1 case. The concentrations of tegafur in the serum, @entity5 and bladder wall were measured simultaneously. The levels obtained at two hours after rectal administration of the tegafur 3000-mg suppository were 19.420 mcg/ml for @entity16229 and 0.025 mcg/ml for @entity1487 in the serum, 13.170 mcg/g for @entity16229 and 0.140 mcg/g for @entity1487 in the @entity150 , and 20.447 mcg/g for @entity16229 and 0.252 mcg/g for @entity1487 in the bladder wall. Eruption was observed in 1 case. No other side effects were noted.
