[Glycosylated hemoglobin A1c as a diagnostic test for diabetes mellitus in adolescents with overweight and XXXX ].

@entity28 @entity5710 @entity2286 @entity3918 @entity413
BACKGROUND: In 2009 it was introduced a new diagnostic criteria based on hemoglobin A1c (HbA1c) greater than or equal to 6.5 % in the adult population; some studies suggest that the cutoff may be smaller in pediatric population. The objective was to determine the utility of HbA1c greater than or equal to 6.5 % as a diagnostic test for @entity3918 in Mexican adolescents with overweight or @entity28 . METHODS: Full somatometry was performed. Also, Tanner stage, blood pressure, blood @entity413 , @entity413 tolerance curve (GTC) and HbA1c were analyzed. Specificity, sensitivity, positive and negative predictive values and ROC curve were calculated for the diagnosis of @entity3918 with HbA1c. RESULTS: 109 adolescents between 10 and 16 years referred for @entity28 or overweight plus comorbidities were studied; 58 % were females, the age was of 13    1.74 years, the BMI percentile 95.3, and the HbA1c 5.73    0.9 %. It was made a diagnosis of @entity3918 in 9 cases (8.3 %), @entity5710 in 8 (7.3 %) and normal @entity413 tolerance in 92 (84.4 %). The HbA1c mean was 5.6    0.04, 5.7    0.4, and 5.6    0.73 %, respectively. HbA1c greater than or equal to 6.5 % had a sensitivity of 12.5 %, a specificity of 89.8 %, a @entity2286 of 10.65 and a NPV of 14.28. The best cutoff point for diagnosing @entity3918 through ROC curve was 5.45 %, with a sensitivity of 62.5 %, a specificity of 57.1 %, @entity2286 2.53 and NPV 33.3. CONCLUSIONS: The level of HbA1c greater than or equal to 6.5 % had low sensitivity and specificity for the diagnosis of @entity3918 . A lower cutoff point is insufficient to use HbA1c as a diagnostic criterion. These results are consistent with the ones of other journals.
