Transcervical needle biopsy for the differential diagnosis between uterine @entity242 and XXXX .

@entity1 @entity242 @entity5 @entity1822 @entity2909
BACKGROUND: The clinical differential diagnosis between uterine @entity242 and @entity2909 is difficult even with magnetic resonance imaging (MRI). Therefore, a considerable number of @entity1 have undergone hysterectomies due to an indication of "suspected @entity5 " based on @entity5 size alone. However, approximately 80% of these hysterectomies have been judged to have been recommended inappropriately. In such situations, reliable preoperative diagnostic tests are required. The authors have evaluated the accuracy of needle biopsy for @entity5 , a procedure that to the authors' knowledge has been performed infrequently. METHODS: Transcervical needle biopsy was performed in 435 @entity1 with @entity5 . The biopsy specimens were scored for degree of @entity5 according to the histopathologic criteria proposed by Bell et al. Histopathologic evaluation of surgical specimens and clinical outcome after 2 years of follow-up were used as the reference standards. RESULTS: Of 435 @entity1 , 7 had uterine @entity242 , 4 of which were scored as > or = 4 points and were diagnosed as " @entity242 " by needle biopsy alone. No @entity242 cases were included in the group of @entity1 with a score of 0. The cutoff score combining the highest sensitivity and specificity with respect to distinguishing @entity1822 from uterine @entity2909 was 2; sensitivity, specificity, and positive and negative predictive values were 100%, 98.6%, 58%, and 100.0%, respectively. CONCLUSIONS: Transcervical needle biopsy using histopathologic scoring is a reliable diagnostic test for the differential diagnosis between uterine @entity242 and @entity2909 . This diagnostic method, combined with MRI screening, could reduce the number of @entity1 currently undergoing unnecessary surgery.
