The right ventricular systolic to diastolic duration ratio: a simple prognostic marker in XXXX ?

@entity1 @entity336 @entity168 @entity2914 @entity299
AIMS: (i) To compare the ratio of right ventricular systolic to diastolic duration ( @entity168 / @entity336 ) in @entity1 with @entity2914 ( @entity2914 ) and normal controls and (ii) to examine its association, if any, with outcomes in @entity2914 . METHODS:     Retrospective chart and echocardiographic review of consecutive neonates (<1 month old) with @entity2914 and term controls without structural @entity299 . Right ventricular @entity168 / @entity336 was calculated by a single reader. RESULTS: @entity1 with @entity2914 (n = 29) were comparable to controls (n = 27) in their mean ( @entity168 ) age [2.2 (3.3) vs. 2 (4.0) days], birthweight [3 (0.67) vs. 3 (0.69) kg] and proportion of males (48.2% vs. 72.4%). The @entity336 and @entity168 / @entity336 were significantly abnormal in the @entity2914 group, compared to controls. Among @entity1 with @entity2914 , those who died (n = 15) and those who died or required ECMO (n = 17) had significantly shorter @entity336 and higher @entity168 / @entity336 ratio. At a cut-off of 1.3, @entity168 / @entity336 ratio had a sensitivity of 92.8 (95% CI 64-99%) and specificity of 61.5 (32-85%) for prediction of mortality. Significant independent associations with mortality were observed with antenatal diagnosis (p = 0.003) and higher @entity168 / @entity336 ratio (p = 0.04). CONCLUSION: The right ventricular @entity168 / @entity336 ratio is a sensitive objective prognostic marker in @entity1 with @entity2914 . Further studies incorporating @entity168 / @entity336 ratio as a guide to intervention are warranted.
