Improved myocardial contractility with @entity413 -insulin- XXXX infusion during pacing in @entity453 .

@entity1 @entity2227 @entity1568 @entity1160 @entity3265 @entity1133 @entity26 @entity880 @entity544 @entity972 @entity453 @entity1718 @entity493 @entity413
The metabolic and mechanical effects of a solution of @entity413 -insulin- @entity972 (G-I-K) were investigated in 18 @entity1 who underwent diagnostic cardiac catheterization for @entity453 . All @entity1 were paced at a rate of approximately 140 beats/min before and after infusion of G-I-K. Basal and paced left ventricular (LV) end-diastolic pressure, dP/dt, arterial substrate levels and osmolarity were measured in all 18 @entity1 . In 13 @entity1 cardiac index was also measured. In 5 @entity1 arterial-coronary sinus measurements of @entity26 , @entity544 , @entity413 , free @entity1718 , @entity880 , @entity493 , @entity2227 , @entity1160 , @entity3265 and @entity1133 were made, in addition to coronary sinus blood flow. G-I-K increased the blood sugar level to approximately 200 mg/dl and raised the serum osmolarity 9 mosmol. Pacing alone raised the cardiac index 4% and pacing with G-I-K increased the cardiac index 6% (p less than 0.05). Pacing before G-I-K augmented dP/dt (21%) and pacing with G-I-K increased it (30%) (p less than 0.01). The metabolic changes noted included a shift in the respiratory quotient from 0.77 to 0.96 with G-I-K infusion (p less than 0.05). During G-I-K infusion the myocardial @entity26 consumption at rest increased from 17.1 to 21.8 ml/min (23%, p less than 0.05). Myocardial @entity26 consumption during pacing was similar before and after G-I-K infusion. Before G-I-K infusion @entity1568 balance was slightly positive; after G-I-K infusion it was negative with regard to the @entity1568 -containing compounds measured.(ABSTRACT TRUNCATED AT 250 WORDS)
