Comparative efficacy and safety of @entity3477 and @entity3402 in the treatment of odontogenic XXXX and inflammatory infiltrates: a phase II, double-blind, randomized trial.

@entity1 @entity3477 @entity733 @entity158 @entity3402
@entity3477 penetrates well into oromaxillary tissue and covers the causative pathogens that show an increasing resistance to standard antibiotics. Clinical reports suggest that @entity3477 may be effective for the treatment of odontogenic infections that can lead to serious complications. The objective of this prospective, randomized, double-blind, multicenter study was to compare the efficacies and safeties of @entity3477 and @entity3402 for the medical treatment of @entity1 with gingival inflammatory infiltrates and as an adjuvant therapy for @entity1 with odontogenic @entity733 requiring surgical treatment. @entity1 received either 400 mg @entity3477 per os once daily or 300 mg @entity3402 per os four times daily for 5 days consecutively. The primary efficacy endpoint was the percent reduction in @entity1 ' perceived @entity158 on a visual analogue scale at days 2 to 3 from baseline. Primary analysis included 21 @entity3477 - and 19 @entity3402 -treated @entity1 with infiltrates and 15 @entity3477 - and 16 @entity3402 -treated @entity1 with @entity733 . The @entity158 reductions were 61.0% (standard deviation [SD], 46.9%) with @entity3477 versus 23.4% (SD, 32.1%) with @entity3402 (P = 0.006) for @entity1 with infiltrates and 55.8% (SD, 24.8%) with @entity3477 versus 42.7% (SD, 48.5%) with @entity3402 (P = 0.358) for @entity1 with @entity733 . A global efficacy assessment at days 2 to 3 and 5 to 7 showed faster clinical responses with @entity3477 in both @entity733 and infiltrate @entity1 . Rates of adverse events were lower in @entity3477 - than in @entity3402 -treated @entity1 . In @entity1 with inflammatory infiltrates, @entity3477 was significantly more effective in reducing @entity158 at days 2 to 3 of therapy than @entity3402 . No significant differences between groups were found for @entity1 with odontogenic @entity733 .
