[Association of @entity29425 functional polymorphism in the promoter region of XXXX gene with antipsychotic agent-induced @entity1017 ].

@entity1 @entity5066 @entity1243 @entity2644 @entity29425 @entity161 @entity1017 @entity1320 @entity1090
OBJECTIVE: To investigate whether the @entity29425 functional polymorphism in promoter region of @entity1243 gene influencing @entity1017 following antipsychotic agents (APS) acute treatment in @entity161 @entity1 . METHODS: 128 Chinese Han untreated @entity1 with @entity161 (male 61, female 67) with an age and gender matched health controls (n = 38) were recruited. The polymorphism of @entity1243 gene was determined with PCR-RFLP technique. MRI determined abdominal body fat in 22 controls and 30 @entity1 on admission and after 10 weeks treatment with @entity1090 or @entity2644 . Body mass index (BMI) was measured on admission and every week subsequently (for @entity1 ). RESULTS: There were average increases in (6.2 +/- 5.7)% of baseline weight and in (38.5 +/- 42)% of baseline abdominal subcutaneous fat (SUB) and in (40.0 +/- 41.2)% of baseline @entity1320 ( @entity1320 ) 10 weeks after treatment. There were no significant differences in the distribution of allele and genotypes either between the @entity1 and controls or between gender groups. It was found significantly increased @entity1017 in the @entity1 with the -2548AA genotype (chi(2) = 7.529, df = 1, P = 0.006; OR = 1.941; 95% CI: 1.175 - 3.207); The genotypes had no influence on the baseline weight indicators both in @entity1 and controls. However, as compared with the @entity1 with G allele, the @entity1 with @entity5066 genotype had significant increase in BMI (P = 0.003) and SUB (P = 0.009). CONCLUSION: The finding identify that the @entity29425 polymorphism in promoter region of @entity1243 gene associated with APS-induced @entity1017 and abdominal fat deposition and distribution. -2548AA may be a genetic risk factor for the development of @entity1017 and body fat deposition in Chinese Han @entity161 @entity1 during APS acute treatment.
