Contrast-free detection of XXXX in @entity1121 @entity1 with diffusion-weighted cardiovascular magnetic resonance.

@entity1 @entity296 @entity82 @entity2286 @entity2287 @entity583 @entity1121
BACKGROUNDS: Previous studies have shown that diffusion-weighted cardiovascular magnetic resonance (DW-CMR) is highly sensitive to replacement @entity82 of chronic @entity583 . Despite this sensitivity to @entity583 , DW-CMR has not been established as a method to detect @entity296 . We propose the application of a recently developed DW-CMR technique to detect @entity296 in @entity1121 ( @entity1121 ) @entity1 and compare its performance with established CMR techniques. METHODS: @entity1121 @entity1 (N   =   23) were recruited and scanned with the following protocol: standard morphological localizers, DW-CMR, extracellular volume (ECV) CMR, and late @entity2287 enhanced (LGE) imaging for reference. Apparent diffusion coefficient (ADC) and ECV maps were segmented into 6 American Heart Association (AHA) segments. Positive regions for @entity296 were defined as: ADC   >   2.0   m(2)/ms and ECV   >   30  %. Fibrotic and non-fibrotic mean ADC and ECV values were compared as well as ADC-derived and ECV-derived @entity82 burden. In addition, @entity82  regional detection was compared between ADC and ECV calculating sensitivity, specificity, positive predictive value ( @entity2286 ), and negative predictive value (NPV) using ECV as the gold-standard reference. RESULTS: ADC (2.4        0.2   m(2)/ms) of fibrotic regions (ADC   >   2.0   m(2)/ms) was significantly (p   <   0.01) higher than ADC (1.5        0.2   m(2)/ms) of non-fibrotic regions. Similarly, ECV (35        4  %) of fibrotic regions (ECV   >   30  %) was significantly (p   <   0.01) higher than ECV (26        2  %) of non-fibrotic regions. In fibrotic regions defined by ECV, ADC (2.2        0.3   m(2)/ms) was again significantly (p   <   0.05) higher than ADC (1.6        0.3   m(2)/ms) of non-fibrotic regions. In fibrotic regions defined by ADC criterion, ECV (34        5  %) was significantly (p   <   0.01) higher than ECV (28        3  %) in non-fibrotic regions. ADC-derived and ECV-derived @entity82 burdens were in substantial agreement (intra-class correlation   =   0.83). Regional detection between ADC and ECV of diffuse @entity82 yielded substantial agreement (k   =   0.66) with high sensitivity, specificity, @entity2286 , NPV, and accuracy (0.80, 0.85, 0.81, 0.85, and 0.83, respectively). CONCLUSION: DW-CMR is sensitive to @entity296 and is capable of characterizing the extent of @entity82 in @entity1121 @entity1 .
