Inter- and intra-tumoral relationships between vasculature characteristics, @entity1365 and budding in XXXX .

@entity6520 @entity14 @entity1365
UNASSIGNED: Vascular characteristics, hypoxia and tumor budding are features that have been implied in the biology and prognosis of @entity14 . Internal relationships and the inter- and intra-tumoral variation of these tumor properties remain to be determined. In the current study we have characterized blood vessel status in different areas of @entity14 and in the peritumoral fibroblastic stroma. Analyses of these characteristics have been supplemented by characterization of budding and hypoxia. Analyses revealed significantly lower values of @entity6520 ( @entity6520 ) and @entity6520 ( @entity6520 ) at the invasive front and surrounding stroma as compared to the tumor center. Also, the number of vessels (VN) in the peritumoral stroma was higher than in the center. Thus, tumor center displays larger and fewer vessels as compared to the tumor periphery. @entity1365 expression was correlated directly with VN (r=0.351, p=0.028) and inversely with @entity6520 and @entity6520 (r=-0.432, p=0.006 and r=-0.484, p=0.002) at the invasive front. Moreover, @entity1365 expression, @entity6520 at the invasive front, and VN in the surrounding peritumoral stroma, were associated with budding score (r=0.574, p<0.000, r=-0.340, p=0,034 and r=-0.389, p=0.025 respectively). Furthermore, @entity1365 , budding score, vessel number in peritumoral stroma, and vessel size in the invasive front, were significantly different in tumors with or without lymph node metastasis. This study reports previously unrecognized relationships between localization-specific vascular characteristics, hypoxia and tumor budding. The findings suggest potential functional relationships, which should be further explored, and also highlight the inter-tumoral variations in vasculature, which is highly relevant for ongoing efforts to identify vessel-based biomarkers.
