[The uremic toxin, XXXX , signifies cardio-renal risk and intestinal-renal relationship].

@entity1 @entity5507 @entity177 @entity1381 @entity19772 @entity65 @entity6634
@entity1381 and condition is primarily a result of @entity177 in which uremic toxins are accumulated. More and more attention is paid to possibilities for @entity1381 , which not only means dialysis, but also takes into account special dietary considerations and treatments, which aim to absorb the toxins or reduce their production. These uremic toxins, which also increase the cardiovascular risks, play a major part in morbidity and mortality of @entity1 suffering from @entity177 and those receiving renal replacement therapy. One of them is a member of the @entity19772 group, the @entity6634 . This toxin is difficult to remove with dialysis and is an endogenous protein-bound uremic toxin. Today we know that @entity6634 is a vascular-nephrotoxic agent, which is able to enhance progression of @entity65 . It is of particular importance that because of its redox potency, this toxin causes oxidative stress and antioxidant effects at the same time and, on top of that, it is formed in the intestinal system. Its serum concentration depends on the nutrition and the tubular function and, therefore, it can also signal the progression of @entity177 independently of glomerular filtration rate. Successful removal of @entity6634 reduces the morbidity and mortality and improves survival. Therefore, it could be a possible target or area to facilitate the @entity5507 in @entity177 . The use of probiotics and prebiotics with oral adsorbents may prove to be a promising opportunity to reduce @entity6634 accumulation.
