Cytokine gene polymorphisms in XXXX .

@entity650 @entity32 @entity28 @entity310 @entity27 @entity71841 @entity687
OBJECTIVE: The pro-inflammatory cytokines, @entity310 , @entity650 , and @entity687 are elevated in @entity27 ( @entity27 ). Cytokine gene interactions are complex and haplotype analysis may be more informative. We hypothesized that the effects of @entity310 in @entity27 might be due to linkage disequilibrium of the @entity310 (-308A) single nucleotide polymorphism (SNP) with other polymorphisms within the @entity310 gene, and that predisposition to elevated @entity650 and @entity687 levels in @entity27 might be attributable to pro-inflammatory @entity650 and @entity687 gene promoter polymorphisms. METHOD: 173 subjects were classified as having definite @entity27 or not on the basis of apnoea-hypopnoea frequency, sex, age, and symptoms. Population controls comprised 192 random UK blood donors. Genotyping was undertaken for the @entity310 promoter polymorphisms (-1031, -863, -857, -238), two lymphotoxin-a polymorphisms (intron 1 and @entity71841 ), the pro-inflammatory @entity650 gene promoter polymorphism (-174), and @entity687 gene promoter polymorphisms (-251; -781). RESULTS: There was no significant difference between groups re: genotype/allelic frequency in the genes investigated. Association between disease status and the @entity310 alleles independently (TNF-103, TNF-803, TNF-857, TNF-238) with five haplotypes of @entity310 was not significant (p   >   0.05). There was no difference in allelic or genotypic frequencies between @entity28 and @entity28 subjects with @entity27 . The @entity310 (-863A) allele alone, was significantly associated with @entity28 (OR 2.4; CI95% 1.1-5; p   =   0.025). CONCLUSION: Only the @entity310 (308A) SNP appears to be significantly associated with @entity27 . The impact of cytokine gene polymorphisms on phenotypic expression of @entity32 in @entity27 is likely to be complex.
