Tumor oxygenation and acidification are increased in XXXX xenografts after exposure to @entity4854 and @entity7990 .

@entity1 @entity320 @entity5 @entity19 @entity26 @entity221 @entity7990 @entity915 @entity4854 @entity413
Tumor @entity26 tension and extracellular pH (pH(e)) are physiological parameters that can be manipulated to improve current @entity5 therapies. Many @entity1 @entity5 consist of cells that are chronically exposed to low pH(e). Exposure of @entity5 cells in culture to @entity413 decreases @entity26 consumption ( @entity26 sparing or Crabtree effect), and while this effect is absent in low pH-adapted @entity5 cells, it can be restored by combining the respiratory inhibitor @entity7990 ( @entity7990 ) with @entity413 (Burd et al., @entity5 Res. 61, 5630-5635, 2001). The effects of @entity4854 and MIBG on @entity5 @entity26 tension and on pH(e) were investigated in @entity1 @entity320 xenografts in @entity915 @entity19 . An oral gavage of 1 M @entity413 (2 g/kg) increased the average blood @entity413 concentration from <140 mg/dl to approximately 400 mg/dl. Although @entity5 pH(e) decreased from pH 6.7 to pH 6.5 (P < 0.01) after about 60 min, no change in @entity5 @entity26 tension was observed. However, when oral @entity413 and MIBG (15 mg/kg) were administered together, @entity26 tension increased from 2.8 mmHg to approximately 17 mmHg, and @entity5 pH(e) decreased from pH 6.7 to pH 6.3 (P < 0.01) after about 115 min. In conclusion, administration of @entity413 together with MIBG increases @entity5 @entity26 tension and also increases the magnitude and duration of acidification. @entity4854 plus MIBG has the potential to improve response to radiation therapy as well as to @entity221 and some chemotherapies.
