"Apocrine @entity19274 and XXXX : A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma.

@entity1 @entity1377 @entity39 @entity5 @entity1313 @entity4206 @entity787 @entity19274 @entity5822 @entity158 @entity3 @entity652 @entity9296
UNASSIGNED: @entity1377 ( @entity1377 ) is a rare, underreported, and often misdiagnosed @entity5 of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of @entity158 , slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, @entity19274 ( @entity19274 ) is a cystic @entity652 that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of @entity1377 , including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was @entity19274 or @entity9296 . However, complete excision of the @entity5 led to a final diagnosis of @entity1377 . After an adequate treatment, no recurrence or @entity3 was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, @entity39 , or pleomorphism was observed. However, complete excision revealed @entity1313 involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for @entity5822 , S-100 protein, @entity787 , @entity4206 , smooth muscle actin, and calponin. @entity1377 is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the @entity1 for the @entity5 's potential recurrence and @entity3 . Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of @entity19274 or @entity9296 on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying @entity1377 , and a wider excision should be performed.
