Natural killer and natural killer-T cells in XXXX .

@entity1 @entity16301 @entity32 @entity404 @entity1569 @entity6 @entity2940 @entity21319 @entity3138 @entity4755 @entity792 @entity4071 @entity9706 @entity15 @entity14434 @entity405
Psoriasis is characterized by a dermal and epidermal infiltrate comprised predominantly of @entity404 (+) and @entity405 (+) T cells, respectively. These cells behave in an antigen-dependent manner, which suggests that @entity1569 may be a T-cell-mediated @entity792 . Psoriasis shares certain immunological features with recognized autoimmune conditions such as @entity6 and @entity15 , in both of which a pathogenic role is postulated for natural killer (NK) cells and @entity14434 ( @entity14434 ) cells. However, there are few studies assessing the role of NK and @entity14434 cells in @entity1569 . We sought to determine whether NK and @entity14434 cells are present in @entity1569 . Skin biopsies were taken from the active edge of a @entity1569 plaque and from uninvolved skin at least 5 cm away from involved skin of ten @entity1 with chronic @entity1569 . Skin from four normal subjects was used as controls. Using an immunoperoxidase technique, cryostat sections were stained using antibodies to T-cell markers @entity3138 , CD3, @entity404 and @entity405 ; cutaneous leucocyte associated antigen; NK cell markers @entity4071 , @entity2940 , @entity4755 , @entity9706 and @entity16301 ; and the @entity14434 cell marker @entity21319 . There were significantly more cells expressing T cell markers, NK cell markers @entity4071 , @entity4755 , @entity9706 and @entity16301 and @entity14434 cell marker @entity21319 in involved skin than in uninvolved or normal skin ( P<0.01). There was no difference in the number of cells expressing @entity2940 . Cells expressing NK markers were found most commonly in the papillary dermis immediately subjacent to the dermoepidermal junction. Cells expressing @entity4755 were found in significantly higher numbers in the epidermis and reticular dermis of involved skin. This study demonstrates that cells expressing NK markers and @entity14434 cell markers are present in plaques of @entity1569 . The exact roles of NK and @entity14434 cells in @entity1569 are unclear, although they may modulate @entity32 and act as a source of Th(1) cytokines important in the psoriatic process.
