Effect of Static Compressive Strain, Anisotropy, and Tissue Region on the Diffusion of XXXX in Meniscus Fibrocartilage.

@entity413 @entity528 @entity571
@entity571 ( @entity571 ) is a significant socio-economic concern, affecting millions of individuals each year. Degeneration of the meniscus of the knee is often associated with @entity571 , yet the relationship between the two is not well understood. As a nearly avascular tissue, the meniscus must rely on diffusive transport for nutritional supply to cells. Therefore, quantifying structure-function relations for transport properties in meniscus fibrocartilage is an important task. The purpose of the present study was to determine how mechanical loading, tissue anisotropy, and tissue region affect @entity413 diffusion in meniscus fibrocartilage. A one-dimensional (1D) diffusion experiment was used to measure the diffusion coefficient of @entity413 in porcine meniscus tissues. Results show that @entity413 diffusion is strain-dependent, decreasing significantly with increased levels of compression. It was also determined that @entity413 diffusion in meniscus tissues is anisotropic, with the diffusion coefficient in the circumferential direction being significantly higher than that in the axial direction. Finally, the effect of tissue region was not statistically significant, comparing axial diffusion in the central and horn regions of the tissue. This study is important for better understanding the transport and nutrition-related mechanisms of @entity528 and related @entity571 in the knee.
