Splenotoxicity associated with @entity242 in @entity35 fed high doses of D _ C Red No. 9 or XXXX .

@entity82 @entity1560 @entity242 @entity548 @entity7492 @entity72500 @entity5 @entity17072 @entity1373 @entity75 @entity35 @entity9308
A histopathologic review of F344 @entity35 spleens from the National Toxicology Program-National @entity5 Institute bioassays of barium salt of @entity72500 [(D _ C Red No. 9) CAS: 516-00-21] and @entity9308 @entity7492 (CAS: 142-04-1) was conducted to assess splenotoxic changes associated with @entity242 induced by these @entity17072 . Four @entity1560 (FM), @entity82 (FIB), @entity1373 ( @entity1373 ), and @entity548 --were markedly increased in incidence and severity in males treated with high doses of either D _ C Red No. 9 or @entity9308 @entity7492 . Females treated with high doses of either of these compounds showed similar but less severe changes. FIB and FM showed strong group correlations with @entity5 incidence (r greater than or equal to 0.87). All groups that demonstrated FM also demonstrated @entity242 ; groups without the FM lesions did not exhibit @entity5 . The morphologic similarity of the FIB and @entity1373 lesions to the induced @entity242 suggests that these lesions are preneoplastic. Moreover, the treatment-related @entity75 appear to be precursors of the induced @entity242 . Carcinogenicity studies with serial sacrifices at varying intervals will be required for experimental verification of these conclusions. A schema, based on the findings of the study, suggests a hypothetical pathway for the progression of the treatment-related @entity75 from onset to @entity5 formation.
