D1 receptors in the nucleus accumbens-shell, but not the core, are involved in mediating @entity1068 -seeking behavior of XXXX -preferring ( @entity7956 .

@entity10095 @entity7956 @entity935 @entity167 @entity14616 @entity55908 @entity35 @entity285 @entity1068
UNASSIGNED: Clinical and preclinical research suggest that activation of the mesolimbic @entity935 (DA) system is involved in mediating the rewarding actions of drugs of abuse, as well as promoting drug-seeking behavior. Inhibition of @entity14616 receptors in the nucleus accumbens (Acb) can reduce @entity1068 ( @entity167 )-seeking behavior of non-selective @entity35 triggered by environmental context. However, to date, there has been no research on the effects of D1 receptor agents on @entity167 - seeking behavior of high @entity285 -preferring ( @entity7956 following prolonged abstinence. The objective of the present study was to examine the effects of microinjecting the D1 antagonist @entity10095 or the D1 agonist @entity55908 into the Acb shell or Acb core on spontaneous recovery of @entity167 -seeking behavior. After 10weeks of concurrent access to @entity167 and water, @entity7956 underwent seven extinction sessions ( @entity167 and water withheld), followed by 2weeks in their home cages without access to @entity167 or operant sessions. In the 2nd week of the home cage phase, @entity35 were bilaterally implanted with guide cannula aimed at the Acb shell or Acb core; @entity35 were allowed 7days to recover before @entity167 -seeking was assessed by the Pavlovian Spontaneous Recovery (PSR) model. Administration of @entity10095 (1 g/side) into the Acb shell inhibited responding on the @entity167 lever, whereas administration of @entity55908 (0.125 g/side) increased responding on the @entity167 lever. Microinfusion of D1 receptor agents into the Acb core did not alter responding on the @entity167 lever. Responses on the water lever were not altered by any of the treatments. The results suggest that activation of D1 receptors within the Acb shell, but not Acb core, are involved in mediating PSR of @entity167 -seeking behavior of @entity7956 .
