Prognostic effect of mean platelet volume in XXXX with @entity453 . A systematic review and meta-analysis.

@entity1 @entity1423 @entity453 @entity6688 @entity65
UNASSIGNED: Large platelets with high haemostatic activity may lead to increased @entity1423 .. Mean platelet volume ( @entity6688 ), an indicator of platelet reactivity, may emerge as a prognostic marker in @entity1 with @entity453 ( @entity453 ). It was the objective of this study to conduct a systematic review and meta-analysis to assess prognostic effects of @entity6688 on @entity65 ( @entity65 ) in @entity453 @entity1 . We searched MEDLINE and SCOPUS from inception to January 2, 2014. All studies that reported @entity6688 and the incidence of @entity65 in @entity453 @entity1 were included. Two reviewers independently extracted the data. A random-effects model was applied for pooling the mean difference of @entity6688 between @entity1 with vs without @entity65 . Among 30 eligible studies, eight studies reported mean difference of @entity6688 between @entity65 groups, 11 studies reported @entity6688 dichotomous into high vs low @entity6688 groups, and 11 studies reported both. The pooled mean difference was 0.69 fL (95   %CI = 0.36, 1.01), i.   e. @entity1 with @entity65 had a @entity6688 about 0.69 fL higher than non- @entity65 . @entity1 with higher @entity6688 were about 12   % more likely to die than @entity1 with lower @entity6688 (RR 1.12; 95   %CI = 1.02-1.24). However, pooling these effects was based on high heterogeneity and the source of heterogeneity could not be identified. This might be explained by many differences among included studies (e.   g. study population, outcomes of interest, analysate, time between blood collection and @entity6688 analysis, etc). These findings suggest that @entity6688 may be a useful prognostic marker in @entity1 with @entity453 .
