Effects of increased intra-abdominal pressure and volume expansion on renal function in the XXXX .

@entity1 @entity1811 @entity1369 @entity1808 @entity1372 @entity1564 @entity515 @entity1458 @entity972 @entity35 @entity516
BACKGROUND: The effects of increased intra-abdominal pressure (IAP) and volume expansion on renal function in the @entity35 were studied to gain more knowledge of the @entity1458 seen during laparoscopic procedures and to reduce the detrimental renal effects of IAP. METHODS: IAP was elevated to 5 or 10 mmHg by insufflation of @entity515 and maintained for 2 h in anaesthetized and mechanically ventilated @entity35 . @entity35 with normal IAP served as controls. An @entity1808 receptor I antagonist, @entity1564 , was given as a bolus injection and a 5% volume expansion was achieved by i.v. saline infusion. An @entity1811 ( @entity1811 ) inhibitor was also given. Renal parameters were the glomerular filtration rate (GFR), urine production, the urinary concentrations of @entity1372 and @entity972 and the osmolality in the urine. The arterial acid-base balance and blood pressure were also monitored. RESULTS: The GFR deteriorated by 70% during @entity516 ( @entity516 ) of 10 mmHg. There was a dramatic drop in @entity1372 excretion (88-97%). With @entity1564 and elevated IAP, there was a drop in mean arterial pressure (from 90 to 55 mmHg) and the negative renal effects were very pronounced. Renal function was better preserved during elevated IAP in combination with volume expansion. CONCLUSIONS: Capnoperitoneum suppresses renal function, especially in combination with @entity1808 receptor 1 blockade and @entity1811 inhibition. Volume expansion reduces the deleterious effects of @entity516 on renal function during elevated IAP. The results suggest that @entity1 should not be given pharmaceuticals blocking the renin-angiotensin- @entity1369 system prior to procedures that may increase IAP. It may be beneficial, however, to reduce @entity1808 tension by volume expansion.
