Factors associated with the development of XXXX in childhood.

@entity1 @entity1910 @entity16244 @entity566 @entity484
BACKGROUND: The prevalence of peanut @entity566 appears to have increased in recent decades. Other than a family history of peanut @entity566 and the presence of atopy, there are no known risk factors. METHODS: We used data from the Avon Longitudinal Study of Parents and @entity1 , a geographically defined cohort study of 13,971 preschool @entity1 , to identify those with a convincing history of peanut @entity566 and the subgroup that reacted to a double-blind peanut challenge. We first prospectively collected data on the whole cohort and then collected detailed information retrospectively by interview from the parents of @entity1 with peanut reactions and of @entity1 from two groups of controls (a random sample from the cohort and a group of @entity1 whose mothers had a history of @entity484 and who had had @entity484 themselves in the first six months of life). RESULTS: Forty-nine @entity1 had a history of peanut @entity566 ; peanut @entity566 was confirmed by peanut challenge in 23 of 36 @entity1 tested. There was no evidence of prenatal sensitization from the maternal diet, and peanut-specific IgE was not detectable in the cord blood. @entity16244 was independently associated with intake of soy milk or soy formula (odds ratio, 2.6; 95 percent confidence interval, 1.3 to 5.2), @entity1910 and skin creases (odds ratio, 2.6; 95 percent confidence interval, 1.4 to 5.0), and oozing, crusted @entity1910 (odds ratio, 5.2; 95 percent confidence interval, 2.7 to 10.2). Analysis of interview data showed a significant independent relation of @entity16244 with the use of skin preparations containing peanut oil (odds ratio, 6.8; 95 percent confidence interval, 1.4 to 32.9). CONCLUSIONS: Sensitization to peanut protein may occur in @entity1 through the application of peanut oil to inflamed skin. The association with soy protein could arise from cross-sensitization through common epitopes. Confirmation of these risk factors in future studies could lead to new strategies to prevent sensitization in @entity1 who are at risk for subsequent peanut @entity566 .
