Changes in nutritional, functional, and inflammatory markers in advanced XXXX .

@entity1 @entity788 @entity353 @entity3085 @entity204 @entity1851
Weight loss and the acute-phase response have been associated with poor quality of life and survival in advanced @entity788 ; however, little information is available on changes in these factors over time and their interrelationships. This study examined changes in weight, Karnofsky performance status, @entity1851 ( @entity1851 ), and serum albumin in 25 @entity1 with advanced @entity788 given supportive symptomatic treatment only. @entity1 were assessed at approximately monthly intervals on a total of 70 occasions, allowing assessment of changes over 37 intervals. Overall, @entity1 had a median @entity353 of 2.3 kg/28 days. Median @entity1851 levels rose by 15 mg/l, and serum albumin fell by 1 g/l on average over 28 days. Karnofsky performance status fell by 4 points every 28 days. The nine @entity1 assessed close to @entity204 were compared with the 13 assessed close to diagnosis. The increase in @entity1851 level and fall in weight and performance status were significantly greater within eight weeks of @entity204 than within eight weeks of diagnosis. Among @entity1 close to diagnosis, 13% had an elevated @entity1851 compared with 100% of those close to @entity204 . In multivariate analysis, Karnofsky performance status was significantly associated with percent @entity353 and @entity1851 levels. These data further implicate the acute-phase protein response as being associated with the progressive @entity353 seen in @entity1 with advanced @entity788 . Changes appear to accelerate close to @entity204 . Moreover, the development of @entity3085 is associated with a reduction in @entity1 ' functional capacity.
