Stability and availability of @entity205 in 5% dextrose injection or 0.9% XXXX injection.

@entity2634 @entity205 @entity2827
The stability of @entity205 in commonly used i.v. solutions and the percentage of the drug delivered via @entity2634 administration tubing were studied. @entity205 injection was prepared according to the manufacturer's instructions and diluted with 5% dextrose injection (D5W) or with 0.9% @entity2827 injection (NS). Admixtures containing @entity205 2 mg/mL were prepared in @entity2634 minibags (five for each solution) and in glass containers (three for each solution). The sample obtained at time zero from a glass container protected from light was the control. Additional samples were prepared in minibags and run through 70-inch @entity2634 administration sets. An HPLC assay for @entity205 was used. Exposure to room light did not significantly affect @entity205 concentrations. More than 90% of the initial drug concentration remained after 24 hours under all storage conditions, but less than 95% remained after 6 hours in samples diluted with NS and stored in plastic. At times up to 60 minutes, @entity205 concentrations were significantly different in solutions infused from the minibags through @entity2634 tubing from those in control solutions. Under these conditions, @entity205 is stable in D5W in glass containers or @entity2634 minibags for 24 hours and in NS for 6 hours ( @entity2634 ) to 12 hours (glass). However, because of the potential for leaching of plasticizers, @entity205 admixtures should be stored in glass or used within six hours if stored in @entity2634 minibags. Approximately 10% of the initial drug concentration is lost to 70-inch length @entity2634 infusion tubing.
