Major histocompatibility complex extended haplotypes in XXXX .

@entity1 @entity4106 @entity1252 @entity465 @entity792 @entity942 @entity6103
In a study of 32 white @entity1 with @entity1252 from 28 families, 60 unique chromosome 6 haplotypes were defined. The MHC extended haplotype @entity4106 , SC01, GL02 was strongly disease-associated (0.09 @entity1 , 0.02 controls, RR = 4.5, C.I. = 1.6-12.4, P less than 0.05), while the corresponding haplotype with the GL01 specificity was not increased in frequency (0.05 in both @entity1 and controls). In the present data, the increase in the haplotype bearing GL02 accounted entirely for the association between HLA-DR3 and @entity1252 . Furthermore, the phenotype of complete @entity942 was also strongly disease-associated ( @entity1 0.14, controls 0.02, RR = 8.5, C.I. = 1.8-37.0, P less than 0.05). The only other MHC association in these @entity1 was an increased occurrence of the @entity6103 , SC61 haplotype ( @entity1 0.07, controls 0.01, RR = 6.0, C.I. = 1.8-20.6, P corr. less than 0.05). The relationship between MHC markers and @entity792 appears to be a result of an association with MHC extended haplotypes and @entity465 rather than with individual alleles. It is important that future studies include family members so that such haplotypes can be defined.
