Repeated ingestion of aspartame-sweetened beverage: effect on plasma XXXX concentrations in normal adults.

@entity33520 @entity815 @entity492 @entity535
Aspartame (APM) is a dipeptide sweetener ( @entity33520 ). It has been suggested that excessive use of the product might elevate plasma @entity492 and @entity815 concentrations. Eight normal adults (four male, four female) ingested three successive 12-oz servings of APM-sweetened beverage at two-hour intervals. The study was carried out in two parts in a randomized cross-over design. In one study the beverage was not sweetened. In the other, the beverage provided 10 mg APM/kg body weight per serving. Plasma @entity535 concentrations were measured throughout the six-hour study period. The addition of APM to the beverage had no significant effect on plasma @entity492 concentration. APM addition did increase plasma @entity815 levels 1.64 to 2.05 mumol/dL above baseline values (5.09 +/- 0.82 mumol/dL) 30 to 45 minutes after each dose. However, plasma @entity815 levels did not exceed normal postprandial values at any time. The data indicate ready metabolism of APM's @entity535 content when administered at levels likely to be ingested by individuals who are heavy users of such beverages.
