Migrating motor complex in colectomized ileo stoma XXXX .

@entity1 @entity3974 @entity1139 @entity3897 @entity750
In colectomized @entity1 with ileo stoma, the reflex modulation of small intestinal functions is disturbed, resulting in high enteric stoma outputs and malabsorption. @entity750 has a pivotal role in initiating motor and secretory reflexes involving activation of neuronal @entity750 (3) and smooth muscle muscarinic receptors. We aimed to evaluate the effect of @entity750 ( @entity750 ), @entity3974 and @entity3897 on fasting and stimulated antro-duodeno-jejunal migrating motor complex (MMC) in colectomized @entity1 with ileo stoma compared with healthy subjects. Manometric recordings were obtained in a blinded, age- and gender-matched design. The effects of either standard meal or intravenous @entity750 (10 nmol/kg/min.) treatment with pre-treatment of saline (placebo) or @entity3974 (250  g/kg) or @entity3897 (10  g/kg) were compared. Adverse effects, blood pressure, heart rate and electrocardiographic data were also evaluated. @entity750 increased the frequency (threefold) and migration velocity (twofold) of @entity1139 phase III in both experimental groups. @entity3974 reduced @entity750 -induced frequency of MMC phase III in @entity1 (p < 0.05) but not in healthy subjects. @entity3897 reduced @entity750 -induced frequency of MMC phase III in healthy subjects (p < 0.05). @entity3974 did not alter fasting or postprandial MMC in either experimental group (p > 0.05). @entity3897 did not change fasting MMC in healthy subjects (p > 0.05). We conclude that @entity750 is a stimulator of MMC phase III and that @entity3974 reduces the @entity750 -induced MMC phase III without affecting fasting or postprandial properties in colectomized @entity1 with ileo stoma. Similar effects were observed for @entity750 and @entity3897 in healthy subjects.
