Expression profiling of receptor XXXX kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with @entity420 and @entity957 .

@entity1 @entity7041 @entity8958 @entity5 @entity470 @entity957 @entity2856 @entity319 @entity152 @entity7167 @entity2467 @entity1916 @entity31082 @entity151 @entity4149 @entity420 @entity3270 @entity1722
BACKGROUND: As the comprehensive genomic analysis of @entity151 ( @entity151 ) progresses, novel treatments for this disease need to be explored. With attention to the direct connection between the receptor @entity4149 kinases (RTKs) of @entity5 cells and the pharmacological effects of specific inhibitors, we systematically assessed the RTK expressions of high-grade @entity3270 of the lung [HGNECs, including @entity151 and @entity152 ( @entity152 )]. @entity1 AND METHODS: Fifty-one @entity152 and 61 @entity151 @entity1 who underwent surgical resection were enrolled in this research. As a control group, 202 @entity1 with @entity420 ( @entity420 ) and 122 @entity1 with @entity957 ( @entity957 ) were also analyzed. All the @entity5 were stained with antibodies for 10 RTKs: @entity2467 , @entity470 , @entity2856 , @entity319 , @entity1722 , @entity7167 , @entity1916 , @entity7041 , @entity8958 , and @entity31082 . RESULTS: The @entity152 and @entity151 @entity1 exhibited similar clinicopathological characteristics. The IHC scores for each RTK were almost equivalent between the @entity152 and @entity151 groups, but they were significantly different from those of the ADC or SQCC groups. In particular, @entity2467 was the only RTK that was remarkably expressed in both LCNECs and SCLCs. On the other hand, about 20  % of the HGNEC @entity5 exhibited strongly positive RTK expression, and this rate was similar to those for the ADC and SQCC @entity5 . Intriguingly, strongly positive RTKs were almost mutually exclusive in individual @entity5 . CONCLUSIONS: Compared with ADC or SQCC, @entity152 and @entity151 had similar expression profiles for the major RTKs. The exclusive @entity2467 positivity observed among HGNECs suggests that @entity2467 might be a distinctive RTK in HGNEC.
