Altered neutrophil apoptosis activity is reversed by XXXX in liver ischemia-reperfusion.

@entity1 @entity96 @entity63 @entity5990 @entity2493 @entity1454
Delayed neutrophil apoptosis has been implicated as the mechanism of the systemic inflammatory response. Herein, we examined the effect of @entity2493 on the neutrophil apoptosis in @entity63 and reperfusion of the @entity1 liver. We studied seven @entity1 receiving elective hepatectomy for @entity96 and ten @entity1 receiving laparoscopic cholecystectomy for @entity5990 . Ten milli liters of blood was drawn isolation and incubation of the @entity1 neutrophils. Neutrophil apoptosis activity and @entity1454 expression and respiratory burst activity were assessed flow cytometrically. Another group of neutrophils included those from the @entity1 receiving hepatectomy and isolated and incubated with @entity2493 . Neutrophil apoptosis is delayed from @entity1 after hepatectomy or laparoscopic cholecystectomy when compared with that of the preoperative state. The decrease in the apoptosis activity is more severe in @entity1 receiving hepatectomy as compared with those receiving laparoscopic cholecystectomy. Neutrophils from @entity1 receiving hepatectomy or laparoscopic cholecystectomy are functionally activated. @entity2493 can reverse the delayed process and enhance the apoptosis activity in neutrophils from @entity1 receiving hepatectomy. This study demonstrates that @entity2493 enhances neutrophil apoptosis in @entity1 receiving hepatectomy involving @entity63 and reperfusion of the @entity1 liver.
