Aneuploidy identifies subsets of @entity1 with poor clinical outcome in  grade 1 and grade 2 XXXX .

@entity1 @entity2007 @entity0 @entity5 @entity1349
OBJECTIVE: Histological grade is a well-established prognostic/predictive factor in @entity0 . However, mainly within intermediate categories, @entity1 may have unpredictable outcome. We hypothesised whether ploidy status can distinguish different prognostic groups among @entity0 @entity1 with similar @entity5 grade. MATERIAL AND METHODS: The study involved 684 @entity1 with invasive @entity0 , and median follow-up of 134.5 months. Pathological staging was evaluated according to WHO classification. @entity5 differentiation was assessed using the Nottingham grading system. Ploidy was determined prospectively by DNA flow cytometry. Disease-free survival (DFS) and @entity1349 ( @entity1349 ) were estimated by the Kaplan-Meier method. RESULTS: There were 179 (26.2%) deaths and 239 (33.3%) disease recurrences. For grading, @entity5 were classified as follows: 163 (23.8%) G1, 356 (52.1%) G2 and 165 (24.1%) G3, while 389 (56.9%) @entity5 presented @entity2007 . Ploidy and grading are strongly associated (P  <  0.001). @entity1 with @entity5 showed worse DFS (P  =  0.001) and @entity1349 (P  <  0.001), as well as those with @entity5 in relation to @entity1349 (P  =  0.013). When a subset analysis was performed in early @entity0 @entity1 (n  =  451) with Stage I/IIA of disease, it remained the same significant associations of aneuploid G1 (to @entity1349 ) and G2 @entity5 (to DFS and @entity1349 ) with unfavourable prognosis. CONCLUSIONS: Aneuploidy identifies subsets of @entity0 @entity1 with G1 and G2 @entity5 who showed poor clinical outcome. The finding has therapeutic implications, as these @entity1 are potential candidates to risk-adapted adjuvant therapy.
