Abnormal Gastrointestinal Histopathology in XXXX With Autism Spectrum Disorders.

@entity1 @entity1373 @entity2438 @entity344
OBJECTIVES:: The significance of the association between many gastrointestinal (GI) pathologies and @entity2438 has yet to be discovered. The aim of the present study was to review available evidence documenting any link between @entity2438 and GI histopathology in @entity1 . MATERIALS AND METHODS:: In a systematic review, the following sources were searched: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1980-August week 2, 2009), EMBASE (1980-August week 2, 2009), PubMed (last 180 days), Web of Science, and Scopus, using the terms " @entity2438 " or " @entity344 ." In addition, relevant studies were identified through browsing the reference lists of the included articles for relevant citations. All @entity1 younger than 18 years old with @entity2438 who were examined for abnormal GI histopathology were included. Cohort studies published in the English language, reporting GI histopathological examination findings in @entity1 with @entity2438 , were included. Two independent authors performed data extraction. The methodological quality of each trial was assessed. RESULTS:: Eight studies have reported the histopathological features of the GI tract in @entity1 with @entity2438 and fulfilled inclusion criteria. In general, none of these trials appeared to be of high quality. Apart from @entity1373 , the majority of these findings were not consistent. CONCLUSIONS:: GI pathological findings in @entity1 with @entity2438 have been inconsistent. The present available evidence does not support or refute a link between GI histopathology and @entity2438 in @entity1 . The significance of @entity1373 in these @entity1 is unknown. Large properly designed prospective controlled trials addressing this issue are required.
