Hypothermic retrograde jugular perfusion reduces brain damage in XXXX with @entity6167 .

@entity35 @entity64 @entity6167
OBJECTIVE: To determine whether direct retrograde ice saline infusion in the jugular vein without cardiopulmonary bypass protects @entity35 brains after @entity6167 . DESIGN: Randomized, controlled, prospective study. SETTING: University physiology research laboratory. SUBJECTS: @entity35 (270-320 g, males). INTERVENTIONS: @entity35 were randomized into three groups and given a) no resuscitation after onset of @entity64 ( @entity64 , n = 8); b) ice saline infusion in the femoral vein after onset of @entity64 ( @entity64 + F, n = 8); or c) retrograde ice saline infusion in the external jugular vein after onset of @entity64 ( @entity64 + J, n = 8). @entity35 were exposed to an ambient temperature of 43 degrees C after vessel cannulation. Their mean arterial pressure, heart rate, colonic temperature, and brain temperature were continuously recorded. Survival time and brain pathology were checked. MEASUREMENTS AND MAIN RESULTS: Although colonic temperature decreased 0.8-1.0 degrees C 15 mins after @entity6167 in all groups, no treatment-related changes in colonic temperature were noted in any group. However, significant changes were observed in brain temperature. Fifteen minutes after @entity6167 , brain temperature was 37.6 +/- 0.4 degrees C, 36.1 +/- 0.4 degrees C, and 33.6 +/- 0.8 degrees C in @entity64 , @entity64 + F, and @entity64 + J, respectively. Survival time was 16.1 +/- 2.1, 33.0 +/- 3.8, and >120 mins in these groups, respectively. Neuron damage score was significantly lower in @entity64 + J and without lateralization. CONCLUSIONS: We successfully demonstrated that direct retrograde hypothermic perfusion via the jugular vein without cardiopulmonary bypass protected the brain after @entity64 . This technique cooled the brain but did not significantly interfere with body temperature.
