XXXX concentrations and erythroid progenitors in cord blood of appropriate versus small for gestational age neonates.

@entity1 @entity32 @entity6 @entity167 @entity1195 @entity1307 @entity102 @entity8282 @entity38215 @entity1592 @entity519 @entity68
OBJECTIVE: @entity38215 (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces @entity68 absorption in the gut; its synthesis is enhanced by @entity32 and is reduced during @entity519 . We aimed to study the hypothesis that @entity1 born small for gestational age (SGA) have reduced cord blood concentrations of Pro-Hep. STUDY DESIGN: Cord blood was collected from 20 SGA (term and near term >35 week gestation) @entity1 and 20 appropriate for gestational age (AGA) controls. We excluded @entity1 exposed to maternal @entity102 , smoking, @entity6 , @entity167 or drug use. Both groups had a 1 min Apgar score above or equal to 7 and had normal cord blood pH (above 7.25). ELISA was used to determine serum concentrations of Pro-Hep and @entity1307 ( @entity1307 ). Circulating @entity8282 (+)/ @entity1195 (-)/SSC(low) cells were measured by flow cytometry as an index of erythroid progenitors. RESULT: There were no significant differences between groups in terms of hemoglobin concentrations, and Pro-Hep. In contrast, @entity1307 levels and circulating @entity8282 (+)/ @entity1195 (-)/SSC(low) erythroid progenitors were significantly higher in the SGA group. These differences remained significant even after controlling for gestational age and gravidity. CONCLUSION: Contrary to @entity1307 upregulation during @entity1592 ( @entity1592 ), and higher concentrations of circulating erythroid progenitors, Pro-Hep concentration is not affected by @entity1592 .
