Both exhaled @entity842 and blood eosinophil count were associated with mild XXXX only in non-smokers.

@entity1 @entity748 @entity2023 @entity565 @entity1097 @entity402 @entity56 @entity842
BACKGROUND: The fractional exhaled @entity842 (FENO) and the blood eosinophil count (B-eos) are markers of eosinophilic inflammation used in the diagnosis and management of @entity565 . The relationships between smoking cigarette and both FENO and B-eos are complex and raise questions about the association between these markers and @entity565 in smokers. OBJECTIVE: To determine the relationships between both FENO and B-eos on one hand and @entity565 and @entity402 on the other, according to smoking status. METHODS: FENO and B-eos were measured in respectively 1579 and 1496 of the 1607 middle-aged adults randomly selected from the general population in the cross-sectional ELISABET survey. @entity56 was defined as @entity565 (a self-report of physician-diagnosed @entity565 , and wheezing in the previous 12 months or the use of @entity565 medications) with @entity402 ( @entity2023 or @entity2023 in the previous 12 months, or a previous positive prick test or allergen desensitization therapy). @entity565 was defined as @entity565 without @entity402 . RESULTS: The analysis included 812 (51.4%) never-, 473 (30%) former- and 294 (18.6%) current smokers. A total of 490 (32%) @entity1 were @entity1097 , 80 (5.1%) had @entity56 , and 31 (2%) had @entity565 . Only 16.2% (18/111) of @entity748 were treated with glucocorticoid inhalants, suggesting that among them a majority of @entity1 had mild @entity565 . A positive interaction between smoking status and @entity56 was observed in multivariate models explaining FENO (p=0.003) and B-eos (p=0.001). Thus, compared to those without @entity56 , @entity1 with @entity56 had higher FENO values (+63.4%, 95%CI=[39; 92]) and higher B-eos (+63.2% [38.2; 92.7]) in never and former smokers, but not in current smokers. Lastly, an analysis of receiver operating characteristic curves showed that each of the two markers was able to discriminate moderately @entity56 but only in non-smokers. CONCLUSIONS _ CLINICAL RELEVANCE: FENO and B-eos were associated with the presence of mild @entity56 only in non-smokers, not in current smokers. These findings raise questions about the clinical value of FENO and B-eos in smokers. This article is protected by copyright. All rights reserved.
