@entity1426 and XXXX Risk: A Systematic Review of Observational Studies.

@entity1 @entity2806 @entity1423 @entity12335 @entity2404 @entity1426 @entity731
BACKGROUND: @entity1426 ( @entity12335 ) is a precursor of various lipid mediators. @entity12335 metabolites such as @entity2404 cause @entity1423 and vasoconstriction, thus may lead to @entity731 . It is unclear whether dietary @entity12335 influences the @entity12335 -derived lipid mediator balance and the risk for @entity731 , such as @entity2806 . Considering the function of @entity12335 in @entity731 , it is reasonable to focus on the atherothrombotic type of @entity2806 risk. However, no systematic reviews or meta-analyses have been conducted to evaluate the effect of habitual @entity12335 exposure on @entity2806 risk. We aimed to systematically evaluate observational studies available on the relationship between @entity12335 exposure and the atherothrombotic type of @entity2806 risk in free-living populations. SUMMARY: The PubMed database was searched for articles registered up to June 24, 2014. We designed a PubMed search formula as follows: key words for @entity1 AND @entity2806 AND study designs AND @entity12335 exposure. Thirty-three articles were reviewed against predefined criteria. There were 695 bibliographies assessed from the articles that included both @entity12335 and @entity2806 descriptions. Finally, we identified 11 eligible articles and categorized them according to their reporting and methodological quality. We used the Strengthening the Reporting of Observational Studies in Epidemiology Statement (STROBE) checklist to score the reporting quality. The methodological quality was qualitatively assessed based on the following aspects: subject selection, @entity12335 exposure assessment, outcome diagnosis, methods for controlling confounders, and statistical analysis. We did not conduct a meta-analysis due to the heterogeneity among the studies. All eligible studies measured blood @entity12335 levels as an indicator of exposure. Our literature search did not identify any articles that evaluated dietary @entity12335 intake and tissue @entity12335 as assessments of exposure. Seven of the 11 eligible articles were considered to be of low quality. No articles reported a dose-dependent positive association between an increased @entity2806 risk and @entity12335 exposure. However, most studies did not assess the risk in each subtype of @entity2806 , thus various etiological types of @entity2806 risk were involved in their results. KEY MESSAGES: We did not find a positive association between @entity12335 exposure and @entity2806 risk. Eligible studies reported inconsistent findings: @entity2806 risk did not change or significantly decreased. We could not draw any conclusions due to the limited number of eligible high-quality studies. Further evidence from well-designed observational studies is required. Simultaneously, in order to develop effective preventive measures against @entity2806 , it is imperative to establish standardized definitions, nomenclatures, classifications, and diagnostic procedures.
