Systemic markers of collagen metabolism and XXXX in smokers and non-smokers with pelvic organ prolapse.

@entity620 @entity1 @entity1495
OBJECTIVE: To evaluate systemic markers of collagen metabolism and @entity620 in female smokers with pelvic organ prolapse (POP). Secondary aims were to compare these levels in @entity1 based on prolapse or smoking history alone. STUDY DESIGN: This was a cross-sectional study with four groups: smokers with POP, non-smokers with POP, smokers without POP and non-smokers without POP. Subjects were age-matched based on smoking history and presence of POP. All underwent a fasting blood panel, including plasma procollagen 1-N propeptide (P1NP), @entity1495 ( @entity1495 ), and @entity620 . RESULTS: Ninety-six subjects were enrolled. There were no differences for any demographics other than stage of prolapse, which was highest in non-smokers with POP. Significant variations in the levels of @entity620 and @entity1495 were noted among the four groups. Smokers with POP had lower levels of @entity620 and higher levels of @entity1495 , compared to non-smokers with POP, but this relationship was not statistically significant. However, when contrasting smokers without POP to non-smokers without POP, significant differences in both @entity620 and @entity1495 were documented, confirming an impact of smoking on these markers. Notwithstanding, when evaluated independent of smoking status, @entity620 and @entity1495 levels in @entity1 with POP were similar to those of @entity1 without POP. CONCLUSION: Lower @entity620 and higher @entity1495 among smokers confirms the usefulness of such markers in documenting the smoking's impact on collagen. However, the lack of a difference based on POP suggests these are poor measures for understanding the pathophysiology of this disorder.
