[Expression and clinical value of eukaryotic initiation factor 4E and matrix metalloproteinase-9 in supraglottic and @entity189 and XXXX lymph].

@entity6493 @entity5 @entity189 @entity3 @entity1495 @entity6402 @entity4043
OBJECTIVE: To study the expression of @entity4043 ( @entity4043 )and @entity1495 ( @entity1495 ) in supraglottic, @entity189 , different distance surgical margins and lymphatic @entity3 ; to study the relationship of two molecular markers. METHOD: Expression of elF4E and @entity1495 in @entity189 and different margins were detected by HE-stained, routine pathological section, immunohistochemical SP method and image analysis. RESULT: (1) Immunohistochemical staining for @entity1495 was performed with a monoclonal anti- @entity1495 antibody. The positive expression rate was 68. 4 % . There was significant difference between lymph node @entity3 and no lymph node @entity3 , but there was no significant difference between @entity6402 or @entity6493 ( P >0. 05). There was no significant difference between @entity1495 and @entity189 position,pathology grade ( P> 0. 05). Positive expression rate of @entity1495 was @entity5 , 5 mm, 10 mm different distant margin of supraglottic and @entity189 as tissue progressed adjacent to @entity189 . (2) Staining positive rate of elF4E in supraglottic and @entity189 was 89%. There was significant association between @entity4043 expression intensity and clinical stage, lymphatic @entity3 . The positive expression rate of @entity4043 was increased in sequence from 10 mm, 5 mm distant mucosa tissue to @entity189 nest in supraglottic and @entity189 . (3) Negative expression of @entity1495 and @entity4043 was seen in the normal lymph nodes. @entity1495 positive expression rate was 28% in @entity3 lymph nodes,elF4E was 42 %. (4) There was no significant correlation between elF4E and @entity1495 in margins according to spearman rank correlation test. CONCLUSION: @entity4043 and @entity1495 expression was significantly higher in supraglottic and @entity189 than distant margin and normal mucosa tissue. elF4E positive rate was higher than @entity1495 ,expression sensitivity and reliability of elF4E in margins was higher than @entity1495 . elF4E is a sensitive marker in growth, infiltration and @entity3 of supraglottic and @entity189 .
