Effects of antiarthritic compounds on @entity742 erythrocyte-induced XXXX .

@entity11364 @entity742 @entity500 @entity11464 @entity19 @entity349 @entity4 @entity117 @entity786 @entity5018 @entity3366 @entity2361 @entity7305 @entity619 @entity56 @entity701 @entity13394 @entity230 @entity3352 @entity503
Delayed @entity56 (DTH) to @entity742 erythrocytes (SRBC) in @entity19 is a simple model of cellular immunity mediated primarily by Ly 1+ T-cells. Because little is known about the pharmacology of this model, the therapeutic effects of a variety of antiarthritic agents were tested. Swelling was determined using @entity349 plethysmography and used to determine drug activity. Two immunosuppressive agents ( @entity786 and @entity500 ) and two @entity230 ( @entity619 and @entity701 ) significantly reduced @entity4 . Only one of six nonsteroidal antiinflammatory drugs (NSAIDs), @entity117 , reduced @entity4 . @entity3352 , @entity11464 , and @entity3366 augmented @entity4 and @entity5018 and @entity11364 were inactive. Four disease-modifying antirheumatic drugs (DMARDs), @entity2361 , @entity7305 , @entity503 , and @entity13394 , were tested and none inhibited @entity4 . @entity13394 significantly augmented @entity4 . In conclusion, only @entity230 and immunosuppressive agents had consistent effects on DTH to SRBC. In general, NSAIDs and DMARDs were either inactive or augmented @entity4 . These results suggest that this model may be of use as a routine screen for immunomodulatory agents.
