The prognostic value of autoantibodies against @entity2161 and cardiac troponin-I for clinical outcomes in XXXX .

@entity1 @entity6949 @entity2161 @entity5707 @entity583
AIMS: The prevalence and potential role of autoantibodies against the @entity2161 autoantibody (b1-aab) and cardiac troponin-I (anti- @entity6949 ) in @entity1 with @entity583 ( @entity583 ) are unknown. The aim of this study is to test whether b1-aab and anti- @entity6949 are prevalent in @entity583 @entity1 and to investigate their prognostic value for @entity5707 and clinical outcomes in @entity583 @entity1 . METHODS: This study included 491 @entity1 with first @entity583 at two centers. Serum samples were obtained. b1-aab and anti- @entity6949 were detected by enzyme-linked immunoabsorbent assay. Echocardiographic assessments were performed at admission and following 1 year. The major adverse cardiovascular events (MACEs) were evaluated during a median follow-up period of 37 months. RESULTS: The positive rates of b1-aab and anti- @entity6949 in @entity583 @entity1 were 39.1 and 19.1%, respectively. The extent of @entity5707 correlated with the presence of b1-aab and/or anti- @entity6949 (double positive > single positive > double negative). Logistic regression revealed that both b1-aab [odds ratio (OR) 2.298, 95% confidence interval (CI) 1.561-3.384, P<0.001] and anti- @entity6949 (OR 2.389, 95% CI 1.460-3.909, P=0.001) were predictive of @entity5707 . Cox proportional-hazard regression revealed that b1-aab, but not anti- @entity6949 , was strongly predictive of MACEs (hazard ratio 1.802, 95% CI 1.301-2.496, P<0.001). CONCLUSION: b1-aab and anti- @entity6949 were prevalent in @entity583 @entity1 . Both b1-aab and anti- @entity6949 were independent predictors of @entity5707 , whereas only b1-aab was an independent predictor of MACEs. Our findings suggest that b1-aab and anti- @entity6949 may actively participate in the process of @entity5707 after @entity583 .
