History of XXXX in Relation to Clinical Outcomes in @entity955 : A Cohort Study.

@entity1 @entity1375 @entity64 @entity548 @entity1378 @entity887 @entity1031 @entity955 @entity299 @entity204 @entity1374
BACKGROUND: @entity955 is the most common @entity299 of @entity1378 . The association between history of @entity1378 and @entity64 remains unclear. We sought to determine whether history of @entity1374 is a @entity1031 risk factor in @entity1 with @entity955 . METHODS: @entity1 with @entity955 seen in an academic institution between 2000 and 2010 were identified and followed-up. Clinical events ( @entity64 , @entity548 , all-cause @entity204 ) were recorded and related to @entity1374 . Associations were examined in time-dependent models with adjustment for relevant confounders. RESULTS: Among 8962 @entity1 , 141 @entity1 had a history of @entity1378 , 540 had a history of @entity1375 , and 8271 had no @entity1374 . Mean follow-up was 929  1082 days. A total of 715 @entity64 /systemic @entity887 were recorded, with no significant difference in the rates of these events in @entity1 with a history of @entity1374 versus those without thyroid problems in either univariate or multivariable analysis (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.41-1.76 for @entity1378 ; HR 0.98, 95% CI 0.73-1.34 for @entity1375 ). There were 791 @entity548 events; history of @entity1375 was independently related to a higher rate of @entity548 events (HR 1.35, 95% CI 1.02-1.79). No significant difference between the 3 groups was observed for the incidence of @entity204 . CONCLUSIONS: History of @entity1378 was not an independent risk factor for @entity64 in @entity955 whereas @entity1375 was associated with a higher risk of @entity548 events. These data suggest no additional benefit from the inclusion of @entity1374 in @entity1031 models in @entity955 .
