Activated charcoal in tricyclic antidepressant XXXX .

@entity1 @entity1445 @entity2974 @entity4968
Tricyclic antidepressants ( @entity2974 ) bind to activated charcoal both in vitro and in vivo in healthy volunteers after a therapeutic dose of @entity2974 . These findings provide a basis for the routine use of activated charcoal in @entity2974 @entity4968 . The object of this study was to examine the effect of a single dose of 20 g of activated charcoal in @entity1445 @entity1 . Ninety-one @entity1 from four centres with suspected @entity2974 @entity1445 were entered into a randomized study. Gastric lavage was performed on all @entity1 . Thirty-four received 20 g of activated charcoal and 43 served as controls. Fourteen @entity1 were excluded. Plasma drug concentrations were taken on admission and at 1, 2, 4, 8 and 24 h. The incidence of toxic symptoms was registered during 24 h. There was no significant difference in the area under the plasma drug concentration versus time curve, the peak plasma concentrations or plasma half-lives between the two groups. Toxic symptoms were more frequent in the non-treated groups although this difference was not statistically significant. In @entity1 with @entity2974 @entity1445 initially treated with gastric lavage, a single dose of 20 g of activated charcoal had no effect on the systemic absorption or elimination of @entity2974 .
