Enhanced differentiation and clonogenicity of XXXX endometrial polyp stem cells.

@entity1 @entity548 @entity5399 @entity1478 @entity1867 @entity931 @entity2215
@entity1478 arise from endometrial overgrowth and may cause @entity1867 , @entity548 , and @entity931 . In this study, @entity1478 were harvested from hysterectomized specimens from 6 female @entity1 not on hormone therapy. Endometrial polyp mesenchymal stem cells (EPMSCs) were isolated and characterized. Selected cells were spindle-shaped, and expressed surface markers @entity5399 and CD146. The EPMSCs proliferated actively in vitro. A colony-forming study demonstrates that EPMSCs had a colony-generating capacity. When cultured in a defined medium, EPMSCs can differentiate to osteoblast-, adipocyte-, and neuron-like cells. No @entity2215 ( @entity2215 ) expression was noted. Experimental results demonstrate that EPMSCs are a population of mesenchymal progenitor cells existing in @entity1 @entity1478 that are capable of proliferation, differentiation, and colonogenicity exceeding that of bone marrow stem cells and endometrial stromal cells. These EPMSCs may be an alternative resource of adult stem cells for future regenerative therapy.
