Effects of Acute and Sustained XXXX Manipulations on Performance in a Visual-Signal Detection Task of Attention in @entity35 .

@entity1 @entity1931 @entity73 @entity71 @entity4 @entity406 @entity3795 @entity880 @entity158 @entity35 @entity5591 @entity934
UNASSIGNED: Preclinical Research @entity1 with @entity158 often display @entity73 including @entity71 . The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male @entity35 were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of @entity880 ; (ii) intraplantar injection of @entity406 ; and (iii) intraplantar injection of complete Freund's adjuvant ( @entity3795 ). The muscarinic @entity934 receptor antagonist, @entity5591 was also tested as a positive control. @entity5591 (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher @entity5591 doses increasing omissions. @entity880 (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. @entity406 produced a transient decrease in accuracy while also increasing both response latency and omissions. @entity3795 failed to alter VSDT performance. Although VSDT effects were transient for @entity406 and absent for @entity3795 , both treatments produced mechanical @entity1931 and paw @entity4 for up to 7 days. These results support the potential for noxious stimuli to produce a @entity158 -related disruption of attention in @entity35 . However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT. Drug Dev Res, 2015.    2015 Wiley Periodicals, Inc.
