[ @entity9758 : a severe opportunistic infection in @entity1252 XXXX .]

@entity1 @entity5585 @entity295 @entity66 @entity500 @entity1252 @entity786 @entity3109 @entity1215 @entity9758 @entity378 @entity1907
INTRODUCTION: One of the main issues in @entity1252 ( @entity1252 ) @entity1 is infection, such as @entity378 ( @entity378 ). Of note, @entity1252 @entity1 are susceptible to @entity1907 . However, to our knowledge, this @entity66 was rarely reported in @entity1252 , particularly diffuse or @entity9758 . Therefore, from January 1983 to December 2011, 5,635 @entity1 were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for @entity1252 . CASE REPORTS: Four (1.4%) of our @entity1252 @entity1 had disseminated @entity378 and were described herein. All of them were female gender, received BCG vaccination and did not have a history of @entity378 household contact. The median of current age at @entity378 diagnosis and the period between @entity1252 and @entity378 diagnosis were 17 years old (range 14-20) and 5.5 years (range 2-7), respectively. All @entity1 developed @entity9758 during the course of the disease. The median of @entity1252 Disease Activity Index 2000 (SLEDAI-2K) was 4 (2-16) and the @entity1 were treated with immunosuppressive agents (glucocorticoid, @entity500 and/or intravenous @entity786 ). Two of them presented @entity295 and @entity378 diagnosis was only established at autopsy, especially with lungs, central nervous system and abdominal involvements. Anti- @entity378 therapy ( @entity3109 , @entity1215 and @entity5585 ) was indicated in the other two @entity378 cases, however they deceased. DISCUSSION: @entity9758 is a rare and severe opportunist infection in @entity1252 . This study reinforces the importance of routine searches for @entity378 in @entity1252 @entity1 .
