Effect of Pfaffia paniculata (Brazilian @entity9052 ) on the XXXX in its ascitic form.

@entity137 @entity66 @entity5 @entity19 @entity9052 @entity493 @entity8270
The roots of Pfaffia paniculata (Brazilian @entity9052 ) have been indicated for the treatment of @entity66 , among which the @entity5 . The purpose of this study was to investigate experimentally the possible antineoplastic effect of this root. Firstly, a @entity137 study was performed in which the doses of 400 and 200 mg/Kg of the powdered root were administered by gavage for 10 days to BALB/cICB @entity19 . The @entity19 did not lose weight during the treatment. No increase in serum @entity493 -aminotransferase neither histopathological alteration (liver, kidney and spleen) was observed in @entity19 treated with P. paniculata. The effect of this root on the ascitic @entity8270 in BALB/cICB @entity19 was then investigated. Male @entity19 received, by gavage, once a day, 200 mg/Kg of the powdered root of P. paniculata or distilled water, as control, for 20 days. This protocol started 10 days before @entity5 inoculation with 5 x 10(6) cells i.p., and lasted until 10 days after. The @entity5 was evaluated by the quantification of the volume of the ascitic fluid, relative number of @entity5 cells and total number of @entity5 cells. A decrease in the total ascitic volume was observed in P. paniculata treated @entity19 , that was followed by a numerical decrease in the total number of @entity8270 cells. These results may indicate that P. paniculata anti-inflammatory effects were responsible by the decrease in the total ascitic fluid. In addition, the presence of @entity5 -cell inhibitory factors in P. paniculata roots is in agreement with other in vitro studies. The mechanisms of such @entity5 inhibition should be further investigated.
