Association of XXXX and @entity2204 promoter polymorphisms and primary open-angle glaucoma: a meta-analysis.

@entity725 @entity72037 @entity72035 @entity2204 @entity726 @entity20448 @entity72038 @entity72036 @entity29714
BACKGROUND: @entity725 ( @entity725 ) is the most common form of @entity726 with a genetic predisposition. The relationship between polymorphisms in @entity29714 or @entity2204 promoter region and @entity725 has been addressed in many case-control studies, but the published results were not consistent. METHODS: A meta-analysis assessing the association between five single nucleotide polymorphisms (SNPs) (in @entity29714 promoter: @entity72035 and @entity72036 ; in @entity2204 promoter: @entity20448 , @entity72037 and @entity72038 ) and the risk of @entity725 was performed based on included studies from literature research. In fixed effect model or random effect model, the Mantel-Haenszel (M-H) pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the genetic association. Stratification analysis was also conducted to test the association within Asian or Caucasian populations. RESULTS: Twenty five case-control studies within multiple populations were identified and no publish bias was observed. Significant association was detected between @entity725 risk and @entity29714 @entity72036 in Caucasian (GA+AA vs. GG, OR=0.587, 95% CI=0.437-0.788, P < 0.001). For other SNPs and in other ethnic populations, no statistic evidence was detected for significant association between them and the development of @entity725 . CONCLUSIONS: This meta-analysis suggested a genetic association between one of @entity29714 polymorphism ( @entity72036 ) and the risk of @entity725 only in Caucasian population. The significant heterogeneity for this locus might imply the different @entity725 genetic basis among different populations.
