A Clinicopathological Study of XXXX Nephropathy at King Abdulaziz University.

@entity1 @entity479 @entity6300
INTRODUCTION: @entity6300 nephropathy is a relatively rare idiopathic glomerulopathy characterized by mesangial immunoglobulin and complement deposits with dominance or co-dominance of @entity6300 , with no evidence of systemic lupus erythematosus. We describe the incidence, clinical manifestation, histopathological features, and follow-up of @entity1 with @entity6300 nephropathy at our institute. MATERIALS AND METHODS: Of 750 kidney biopsy specimens obtained in the period of January 2000 to December 2011, all the cases that meet the criteria for the diagnosis of @entity6300 nephropathy were retrieved.   The histological slides were examined and the clinical charts were reviewed by 2renal pathologists. RESULTS: We had 11 @entity1 , all @entity1 , that met the criteria for the diagnosis of @entity6300 nephropathy accounting for an incidence of 1.5%.   The mean age at the time of presentation was 3.7 years and all the @entity1 were presented with nephrotic syndrome. Two @entity1 had microhematuria and 2 had hypertension. Histological examination of these cases showed variable degrees of mesangial cells hypercellularity and matrix expansion with focal segmental glomerulosclerosis observed in 2 cases. Nine @entity1 were @entity479 resistant (82%) and 2 were @entity479 dependent. Six @entity1 required immunosuppressive therapy and 1 @entity1 developed end-stage renal disease. CONCLUSIONS: In our series, @entity6300 nephropathy affected predominantly young @entity1 . Mesangioproliferative pattern was the most frequent histopathological finding in these @entity1 . Clinically, despite @entity479 resistance, the @entity1 had a relatively good outcome; the worst prognostic outcome was associated with collapsing glomerulopathy.
