The value of combined use of @entity7548 and ethanolamine oleate in the management of XXXX esophagogastric varices.

@entity1 @entity8398 @entity295 @entity548 @entity532 @entity1463 @entity1578 @entity7548 @entity2312
BACKGROUND AND STUDY AIMS: Recently, tissue adhesive material has been used to improve the initial control of @entity548 from huge esophagogastric varices, and to prevent them from rebleeding, in contrast to the conventional sclerotherapy. The present study assessed the value of the combined use of the tissue adhesive substance: @entity7548 and @entity8398 oleate 5% for management of @entity548 esophagogastric varices. @entity1 AND METHODS: One hundred and fourteen @entity1 with documented active variceal @entity548 at the time of endoscopy were alternatively randomized into two groups. The combined therapy group included 58 @entity1 who underwent injection using both cyanoacrylate for large esophageal and @entity2312 and a sclerosant agent for remaining varices. The @entity1463 , or control, group included 56 @entity1 , who underwent injection with @entity8398 oleate. RESULTS: This study proved the value of the combined therapy for the initial control of all bleeders (the follow-up period ranged from 12 to 32 months). In the @entity1463 group, failure of the initial control of @entity548 was reported in two cases (3.6%). Recurrent @entity548 occurred in 8.6% in the combined therapy group compared to 25% in the @entity1463 group (p < 0.01). Two months of therapy was required to achieve complete eradication of varices in 56.5% and 21.4% in the combined therapy and the @entity1463 group, respectively. The mean number of sessions needed until the time of evaluation was 2.4 +/- 1.1 in the combined therapy group versus 5.1 +/- 2.3 sessions in the @entity1463 group. The difference showed high statistical significance (p < 0.01). @entity532 occurred less frequently in the combined therapy group. Only one @entity1 in the combined therapy group developed @entity295 after extension of the tissue adhesive material from the site of injection into the portal vein. This @entity1 died of @entity1578 . The mortality in the combined therapy group was lower than that in the @entity1463 group (3.5% and 8.8% respectively, p > 0.05). CONCLUSION: The combined use of tissue adhesive and sclerosant materials seems to be the best plan for rapid eradication of esophagogastric varices within a short time, requiring the lowest number of injection sessions and involving minor complications and low mortality.
