Effect of Subthalamic Deep Brain Stimulation on XXXX -Induced @entity910 in @entity191 .

@entity1 @entity3034 @entity910 @entity191
PURPOSE: To evaluate the effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on @entity3034 -induced peak-dose @entity910 in @entity1 with @entity191 ( @entity191 ). MATERIALS AND METHODS: A retrospective review was conducted on @entity1 who underwent STN DBS for @entity191 from May 2000 to July 2012. Only @entity1 with @entity3034 -induced @entity910 prior to surgery and more than 1 year of available follow-up data after DBS were included. The outcome measures included the @entity910 subscore of the Unified @entity191 Rating Scale (UPDRS) part IV (items 32 to 34 of UPDRS part IV) and the @entity3034 equivalent daily dose (LEDD). The @entity1 were divided into two groups based on preoperative to postoperative LEDD change at 12 months after the surgery: Group 1, LEDD decrease >15%; Group 2, all other @entity1 . Group 2 was further divided by the location of DBS leads. RESULTS: Of the 100 @entity1 enrolled, 67 were in Group 1, while those remaining were in Group 2. Twelve months after STN DBS, Groups 1 and 2 showed improvements of 61.90% and 57.14%, respectively, in the @entity910 subscore. Group 1 was more likely to experience @entity910 suppression; however, the association between the groups and @entity910 suppression was not statistically significant (p=0.619). In Group 2, @entity910 was significantly decreased by stimulation of the area above the STN in 18 @entity1 compared to stimulation of the STN in 15 @entity1 (p=0.048). CONCLUSION: @entity3034 -induced @entity910 is attenuated by STN DBS without reducing the @entity3034 dosage.
