Correlates and outcomes of preserved left ventricular systolic function among older adults hospitalized with XXXX .

@entity1 @entity712 @entity1289
BACKGROUND: @entity712 ( @entity712 ) in older adults is often associated with preserved left ventricular systolic function (LVSF). The objective of this retrospective follow-up study was to determine the correlates and outcomes of preserved LVSF among older adults hospitalized with @entity712 . METHODS: We studied older Medicare beneficiaries hospitalized with @entity712 (n = 1091) who had documented LVSF evaluation (n = 438). LVSF was defined as preserved if left ventricular ejection fraction was > or =40%. The Fisher exact test and the Student t test were used to compare baseline characteristics between @entity1 with preserved versus those with impaired LVSF. Multivariate logistic regression analysis was used to determine the correlates of preserved LVSF. Cox proportional hazards analyses were used to determine the associations between LVSF and both 4-year mortality rates and 6-month readmission rates and the associations between @entity1289 ( @entity1289 ) inhibitor use and 4-year mortality rates, separately, in @entity1 with preserved and impaired LVSF. RESULTS: Of the 438 @entity1 , 200 (46%) had preserved LVSF. @entity1 were more likely to have preserved LVSF (odds ratio [OR] = 2.44, 95% CI 1.57-3.81) than @entity1 . Preserved LVSF was associated with lower 4-year mortality rates (adjusted hazards ratio [HR] = 0.67, 95% CI 0.52-0.86) but not with 6-month readmission rates (adjusted HR = 0.66, 95% CI 0.41-1.09). The use of @entity1289 inhibitors was associated with lower 4-year mortality rates in @entity1 with impaired LVSF (adjusted HR = 0.61, 95% CI 0.43-0.86) but not in those with preserved LVSF (HR = 0.96, 95% CI 0.65-1.42). CONCLUSIONS: Among older adults hospitalized with @entity712 , preserved LVSF was common among @entity1 and was associated with significantly higher morbidity and mortality rates, which were unaffected by treatment with @entity1289 inhibitors.
