Trait and state binge eating predispose towards XXXX craving.

@entity28 @entity6426 @entity935 @entity2072 @entity35
UNASSIGNED: @entity6426 ( @entity6426 ) and drug seeking share similar behavioral features, including loss of control over consumption and compulsive seeking of the craved substance. Previous studies in animal models have demonstrated a complex interaction between 'state' @entity6426 , produced by intermittent access to a palatable diet, and 'trait' @entity6426 , a phenotypical proneness towards overeating. In the present study, we examined the relationship between state and trait @entity6426 and @entity2072 seeking. We used Otsuka Long Evans Tokushima Fatty @entity35 , a genetic model for @entity28 that demonstrates @entity6426 -like behavior, and Long Evans Tokushima Otsuka controls. They received a schedule of limited access to a palatable diet (3   days/week or 5   days/week access to Ensure for a month). Next, they underwent @entity2072 self-administration training (1   mg/kg, 1   hour/day for 10   days) followed by extinction sessions (7   days). We found that the degree of @entity6426 -like behavior and the state and trait @entity6426 combination predicted @entity2072 craving patterns. Lower levels of @entity935 D2 receptors in the prefrontal cortex were correlated with increased drug craving. Moreover, restricted access to an attractive diet was found to be a risk factor for heightened @entity2072 craving, particularly in trait binge eaters, as @entity35 on the 3   days/week access schedule persistently failed to cease @entity2072 seeking throughout extinction. Hence, we postulate a joint role of state and trait @entity6426 as risk factors for heightened @entity2072 craving.
