Effects of the high XXXX dose used in the collaborative behavioral teratology study on brain anatomy.

@entity1276 @entity349 @entity3319 @entity35 @entity5165
Pregnant @entity35 were injected with 0, 6 or 10 mg/kg of @entity3319 on Days 6-9 of gestation. Dams given the 10 mg/kg dose failed to deliver young or produced stillborn. External morphology was normal for @entity35 given either the 0 or 6 mg/kg dose. Whole brains were examined from male and female @entity35 , 21 or 90 days old. External brain dimensions were measured with calipers. Brains were sectioned at three criterion locations. A microprojector was used to project brain sections in order to measure intrastructural distances. Sections were examined with a light microscope to look for abnormalities. Various expected age-related changes were noted showing the sensitivity of the anatomical methods. @entity5165 produced @entity1276 , decreased thickness of cerebral cortex in the parietal section and increased thickness of hippocampus in the occipital section. With these exceptions, the brains of @entity349 -treated @entity35 showed normal development.
