Combined Global Longitudinal Strain and Intraventricular Mechanical Dyssynchrony Predicts Long-Term Outcome in @entity1 With XXXX .

@entity1 @entity3883 @entity712 @entity6 @entity168 @entity73 @entity6475
BACKGROUND: Left ventricular (LV) ejection fraction (EF) and QRS duration enable prediction of outcome in @entity1 with @entity712 ( @entity712 ). We assessed the predictive @entity6475 for prognosis in @entity712 @entity1 . METHODS AND RESULTS: Two-hundred and forty @entity712 @entity1 with LVEF  <=40% were studied. Global LV function and intraventricular @entity3883 were calculated as GLS and @entity168 of the time to peak @entity6475 ( @entity168  ) over 18 LV segments. The added value of GLS and @entity168   for outcome prediction was assessed using nested Cox models. Sixty-six @entity1 (28%) reached the study endpoint of all-cause mortality/heart transplantation over a median follow-up period of 45 months. Baseline variables associated with adverse outcome were age, glomerular filtration rate, pulmonary artery systolic pressure, @entity6 and LV end-systolic volume (model   (2)=69.8). The predictive power of the clinical variables was greater with addition of GLS (  (2)=81.1) or @entity168   (  (2)=102.3) than with LVEF (  (2)=73.9) or QRS duration (  (2)=75.5; both P<0.005). GLS (HR, 1.88; P=0.03) and @entity168   (HR, 1.48; P=0.04) were independent predictors after adjustment for the baseline variables. @entity1 with @entity73 (>= -7.8%) and @entity3883 ( @entity168   >= 72 ms) had poor outcome. CONCLUSIONS: Combined assessment of global LV function and @entity3883 using speckle-tracking strain enabled the prediction of long-term outcome in @entity712 @entity1 .
