The roles of @entity20081 in lipopolysaccharide-induced @entity604 : dual effects of XXXX on bone metabolism via osteoclastogenesis and osteoblast survival.

@entity19 @entity604 @entity5271 @entity13943 @entity20081 @entity16323 @entity1990 @entity637
@entity1990 (lipopolysaccharide), a major constituent of Gram-negative bacteria, regulates proliferation and differentiation of osteoclasts directly or indirectly. This study sought to investigate the functions of the RANK/ @entity5271 pathway in @entity1990 -induced @entity604 in vivo. Wild-type @entity19 or @entity20081 -/- @entity19 were injected @entity1990 with or without @entity16323 ( @entity16323 ) and analyzed histologically. Bone volume was reduced by @entity1990 injection in all groups, and @entity16323 administration prevented the @entity1990 -induced @entity604 regardless of genotypes. @entity1990 -induced enhancement of osteoclastogenesis in wild-type @entity19 was blocked by @entity16323 administration. @entity1990 or @entity16323 did not affect osteoclastogenesis in @entity20081 -/- @entity19 . Interestingly, osteoblast surface was remarkably reduced in @entity1990 -treated @entity20081 -/- @entity19 as a result of enhanced osteoblast apoptosis. @entity13943 , induced by @entity637 in BMC, triggered apoptosis of primary osteoblast only when @entity20081 signal was ablated in vitro. In conclusion, RANK signaling plays a prominent role in osteoclastogenesis downstream of @entity1990 . Furthermore, @entity20081 regulates bone metabolism through not only the regulation of osteoclast differentiation but also osteoblast survival.
