Treatment of squamous cell XXXX : A tertiary cancer centre experience.

@entity1 @entity10911 @entity2167 @entity957 @entity2103 @entity395
OBJECTIVE: @entity2167 ( @entity2167 ) is a @entity395 with variable management strategies and prognosis. We aimed to analyze treatment modalities, prognostic factors and survival outcomes in @entity1 of @entity957 of EAC treated at our institution. METHODS: Forty-three @entity1 of @entity957 of EAC were analyzed for clinical presentation, stage, surgical procedures and radiotherapy (RT) modalities employed. Stell and McCormick staging system was used for staging of the @entity1 . Progression free survival (PFS) was estimated by the use of Kaplan-Meier product-limit method. Log rank test was used to assess the impact of prognostic variables on PFS. Multivariate analysis was performed using the Cox hazard regression model. p value of <0.05 was considered significant for all statistical analysis. RESULTS: Median age was 56 years (range: 12-84 years). Male to female ratio was 31:12. Stage was T1, T2 and T3 in 2, 17 and 18 @entity1 respectively. Sixteen @entity1 underwent surgery. Thirty-six @entity1 received RT (14 received definitive RT, 11 had post-operative RT and 11 had RT with palliative intent). Eight @entity1 (16%) received chemotherapy (5 received concurrent with RT, 2 had adjuvant and 1 had neo-adjuvant chemotherapy). Nine @entity1 (of 11 @entity1 ) achieved a @entity10911 achieved a partial response (PR) after surgery plus post-operative RT. Nine @entity1 and 5 @entity1 respectively achieved CR and PR after definitive RT (with or without concurrent chemotherapy). Of the 11 @entity1 who received palliative RT, 2 had very good objective response (>50%) and 7 @entity1 had PR to palliative RT. After a median follow-up of 16 months, median PFS for the entire cohort was 14 months. Two-year PFS rates were 85.7%, 46.9% and 0% for @entity1 treated with surgery and post-operative RT, definitive RT and palliative RT respectively. On univariate analysis, higher stage (p=0.05) and @entity2103 at presentation (p=0.0008) were significant predictors of inferior PFS. CONCLUSION: @entity1 with @entity2167 present mostly in advanced stage at our centre. Combined higher stage (T3) and @entity2103 at presentation portend poorer outcome. Combined modality treatment with surgery and radiotherapy should be advocated and palliative RT remains a reasonable treatment option in @entity1 with advanced incurable disease.
