Efficacy of intravenous XXXX with exercise in thallium-201 myocardial perfusion scintigraphy.

@entity1 @entity390 @entity66 @entity4341 @entity10279 @entity10 @entity453 @entity850
To assess the feasibility and the value of thallium-201 myocardial perfusion imaging with intravenous @entity4341 in combination with low-level exercise, 81 @entity1 with suspected or proven @entity453 were studied. All @entity1 underwent coronary arteriography. Significant @entity453 ( @entity850 greater than or equal to 50%) was present in 59 @entity1 (73%); multivessel disease (double- and @entity66 ) was observed in 33 @entity1 (42%). The overall sensitivity and specificity of the test were 78% and 86%, respectively. Sensitivity and specificity for detection of multivessel disease were 70% and 92%, respectively. The sensitivity for detecting @entity453 in the RCA, LAD, and @entity10279 was 74%, 82% and 48%, respectively, and the specificity was 85%, 88% and 88%, respectively. With the combined procedure no serious side effects were observed. Mild side effects like @entity10 , vertigo and @entity390 were seen in 12 @entity1 (15%). Twenty volunteers with a less than or equal to 1% likelihood of significant @entity453 were examined in the same manner to determine the maximal specificity of the procedure (100%). Thus, the combination of two different stress procedures (exercise testing and @entity4341 infusion) can be performed safely without serious side effects. The presence, location and extent of significant @entity453 can be assessed to a similar degree as with conventional exercise thallium-201 scintigraphy, which has major implications for the detection of @entity453 in @entity1 who are unable to perform maximal exercise.
