Xenograft survival in two species combinations using total-lymphoid irradiation and XXXX .

@entity706 @entity870 @entity95 @entity205 @entity35
@entity706 ( @entity706 ) has profound immunosuppressive actions and has been applied successfully to allotransplantation but not xenotransplantation. @entity205 ( @entity870 ) has not generally permitted successful xenotransplantation of organs but has not been used in combination with @entity706 . @entity706 and CsA were given alone and in combination to @entity35 that were recipients of hamster or @entity95 cardiac xenografts. Combined @entity706 and CsA prolonged survival of hamster-to- @entity35 cardiac xenografts from three days in untreated controls to greater than 100 days in most recipients. @entity706 alone significantly prolonged @entity95 to @entity35 xenograft survival with doubling of survival time. However, combined treatment did not significantly prolong @entity95 -to- @entity35 cardiac xenograft survival compared with @entity706 alone. The hamster and @entity35 are phylogenetically closely related. Transplants from hamsters to @entity35 are concordant xenografts since the time course of unmodified rejection is similar to first-set rejection of allografts. Although the @entity95 -to- @entity35 transplant is also between concordant species (average survival of untreated controls: 3.2 days) the @entity95 and @entity35 are more distantly related. These results suggest that @entity706 is an effective immunosuppressant when applied to cardiac xenotransplants in these animal models; that the choice of species critically affects xenograft survival when @entity706 and/or CsA are used for immunosuppression; and that the closely related species combination tested has markedly prolonged (greater than 100 days) survival using combined @entity706 and CsA.
