Ultra-early study of @entity4 formation in XXXX using diffusion MRI and ADC mapping.

@entity1 @entity4 @entity131 @entity130
OBJECTIVE: Our previous studies have reported that heterogeneous mechanisms exist in early @entity4 formation in @entity131 , and cytotoxic @entity4 plays an important role within 48 hours post- @entity130 . It is remains unclear, when @entity4 begins to develop following injury. In order to determine the time course of @entity4 development, diffusion imaging and ADC (apparent diffusion co-efficient) mapping was performed in 10 @entity1 within 24 hours post- @entity130 with @entity131 . METHODS: Diffusion imaging and ADC mapping were performed employing 1.0 T echo planar MRI. ADC values were indicated as a ration relative to the values of intact brain areas. RESULTS: Within 3 hours post- @entity130 , diffusion MRI showed no remarkable changes, and the ADC values were within normal limit (ADC ratio (=contused/normal brain) = 1.00 +/- 0.21, (mean +/- SD)). At 6 hours post- @entity130 , diffusion images demonstrated a low intensity core in the contusion proper and a high intensity rim in the peripheral area of contusion. The ADC value increased in the contusion proper (ADC ratio = 1.26 +/- 0.13) and decreased in the peripheral area (ADC ratio = 0.58 +/- 0.19). CONCLUSIONS: These findings indicated that early cellular swelling in the peripheral area of contusion begins within 6 hours following injury. This delayed occurrence of contusion-induced cellular swelling suggests that the CBF does not decrease to ischemic level immediately following injury.
