[Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of XXXX ].

@entity1 @entity981 @entity1261 @entity5022 @entity3052 @entity1778 @entity2132 @entity1860
OBJECTIVE: To explore the feasibility of HLA mismatched hemopietic stem cell transplants for the treatment of @entity1778 . METHODS: Between July 2000 and December 2001, seven @entity1 received hemopietic stem cell transplants(HSCT) with HLA mismatched family donors, including 3 @entity1860 ( @entity1860 ), 3 @entity3052 ( @entity3052 ), and 1 @entity981 ( @entity981 ). Stem cell sources were bone marrow(n = 1) or @entity1261 mobilized peripheral blood (n = 6). All the @entity1 were conditioned with busulfan (BU) 12 mg.kg-1 and cyclophosphamide (CY) 3.6 g.m-2, of whom 4 were conditioned with additioned antithymocyte globulin(ATG). @entity2132 ( @entity2132 ) prophylaxis regimen consisted of cyclosporin-A (CSA), methotrexate (MTX) and mycophenolate mofetil(MMF). RESULTS: One @entity1 received 3.41 x 10(8) kg-1 mononuclear cells(MNC) from bone marrow; six @entity1 received a mean number of 8.46 x 10(8) kg-1 (4.3 x 10(8)-15.4 x 10(8) kg-1) MNC from peripheral blood. The mean time of ANC > 0.5 x 10(9) @entity5022 was day 13 (11-16), and BPC > 20.0 x 10(9) @entity5022 was day 16 (11-23). All the @entity1 got engraftment successfully and attained CR. Acute I-II @entity2132 occurred in 3(42.9%) @entity1 , no acute III-IV @entity2132 occurred and extensive @entity2132 did in 2(28.6%) @entity1 . All the @entity1 were alive and well after 6-24 months' follow-up. CONCLUSION: (1) BU/CY plus ATG appears to be an effective conditioning regimen for HLA mismatched allogenic stem cell transplants. (2) @entity1261 mobilized peripheral blood stem cells may be the source of stem cells even for HLA mismatched hemopietic stem cell transplants.
