Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against XXXX .

@entity4315 @entity1527 @entity2348 @entity1068 @entity39320
The activities of crude plant extracts of five plants popularly used in Guatemala against @entity2348 and some of their fractions have been evaluated against the trypomastigote and epimastigote forms of @entity1527 in vitro. The most active fraction of Neurolaena lobata has also been screened in vivo. Main in vitro activities against trypomastigotes have been observed for the @entity4315 and @entity1068 extracts of N. lobata (Asteraceae). Both extracts were also active against epimastigotes, whereas all other extracts tested had no effect on epimastigotes. For the @entity4315 extracts of Petiveria alliacea (Phytolaccaceae) and Tridax procumbens (Asteraceae) a marked inhibition of trypomastigotes has been found. Also the @entity1068 extracts of Byrsonima crassifolia (Malpighiaceae) leafs and Gliricidia sepium (Papilionaceae) bark showed some trypanocidal activity. Fraction 2 of the @entity1068 extract of N. lobata was highly active against @entity1527 as well in vitro as in vivo. The @entity39320 fraction of P. alliacea showed a high inhibition of trypomastigotes in vitro. Also three fractions of the active extract of B. crassifolia inhibited @entity1527 trypomastigotes. No fraction of G. sepium bark extract showed a marked trypanocidal activity.
