XXXX is associated with echocardiographic nonresponse and poor prognosis after cardiac resynchronization therapy.

@entity1 @entity8 @entity712 @entity1009 @entity177
OBJECTIVES: Aims of this study were to investigate the effect of renal function on left ventricular (LV) reverse remodeling and long-term outcome after cardiac resynchronization therapy (CRT), and to explore the relation between LV reverse remodeling and changes in renal function at 6-month follow-up. BACKGROUND: @entity177 is highly prevalent in @entity712 @entity1 , including @entity1 eligible for CRT, and is associated with poor prognosis. METHODS: The study comprised 490 @entity1 undergoing CRT. Response to CRT was defined as a decrease in LV end-systolic volume >= 15% at 6-month follow-up. Primary end point during long-term follow-up was all-cause mortality. RESULTS: At baseline, mean estimated glomerular filtration rate (eGFR) was 70    28 ml/ @entity1009 .73 m  . At 6-month follow-up, 263 @entity1 (54%) demonstrated response to CRT. Responders had an eGFR of 74    26 ml/ @entity1009 .73 m   versus 64    28 ml/ @entity1009 .73 m   in nonresponders (p < 0.001). During long-term follow-up, @entity1 with an eGFR <60 ml/ @entity1009 .73 m   had higher mortality than @entity1 with an eGFR of 60 to 90 ml/ @entity1009 .73 m   or an eGFR >90 ml/ @entity1009 .73 m   (p < 0.001). Finally, responders to CRT had preservation of renal function (/\eGFR -0.6), whereas nonresponders had a slight worsening in renal function (/\eGFR -4.7, p < 0.05). CONCLUSIONS: @entity8 in CRT candidates is associated with nonresponse during 6-month follow-up. Additionally, @entity1 with @entity8 have worse long-term survival after CRT. Response to CRT results in preservation of renal function.
