Intraplaque @entity548 assessed by high-resolution magnetic resonance imaging and XXXX in carotid atherosclerosis.

@entity1 @entity101 @entity548 @entity63 @entity3657 @entity1856 @entity583 @entity850 @entity543 @entity1851
BACKGROUND: Carotid intraplaque @entity548 is a marker of @entity1856 instability. Noninvasive assessment of bleeding can be performed by high-resolution magnetic resonance imaging (MRI), but its association with inflammatory markers has not been clearly demonstrated. METHODS: We evaluated consecutive carotid endarterectomy @entity1 that underwent high-resolution MRI, independent evaluation of neurologic symptoms, @entity1851 measurement, and histologic analysis. Intraplaque @entity548 was determined by the presence of a hyperintense MRI signal (T1-weighted sequence). RESULTS: The study included 70 predominantly male (66%) and @entity101 (89%) @entity1 (89%) aged 66 +/- 9 years old. MR angiography identified 15 @entity1 (21.5%) with @entity850 between 50% and 69%, 15 (21.5%) with @entity850 between 70% and 90%, and 40 (57%) with @entity850 >90%. High-resolution MRI depicted a hyperintense signal suggestive of intraplaque bleeding in 45 subjects (64%). All @entity1 who had had transient @entity63 attacks >90 days before the surgery showed a hyperintense signal on MRI (P = .007). Age, gender, traditional cardiovascular risk factors, and history of @entity583 or @entity3657 were similar in @entity1 with or without signs of intraplaque bleeding on MRI. There was excellent agreement between acute or recent @entity548 on histologic and MRI findings (kappa coefficient, 0.91; 95% confidence interval, 0.81 to 1.00). Only one of 45 @entity1 (2%) with a hyperintense signal on MRI did not have acute or recent @entity548 in the histologic analysis (P < .001). High-sensitivity @entity1851 levels were similar for different degrees of @entity543 as assessed by MR angiography, but they were significantly higher in clinically unstable @entity1 (P = .006) and in those with a positive hyperintense MRI signal (P = .01). In an aggregated analysis of neurologic symptoms and MRI findings, we found a progressive increase of high-sensitivity @entity1851 levels (P = .02). CONCLUSIONS: Intraplaque @entity548 evaluated by MRI identified neurologically unstable @entity1 with increased levels of high-sensitivity @entity1851 regardless of the degree of @entity543 .
