Radiation treatment for XXXX . A 21-year review.

@entity1 @entity2946 @entity3
One hundred and twenty-two @entity1 with @entity2946 received postoperative irradiation at the Princess Margaret Hospital, Toronto, from 1958 to 1978, inclusive. The surgical procedure in these @entity1 was total resection (44 @entity1 ), subtotal resection (66 @entity1 ), or biopsy alone (12 @entity1 ). Twenty-five @entity1 received adjuvant chemotherapy. Overall 5- and 10-year survival rates were 56% and 43%, respectively. Improved survival rates were associated with an increased degree of resection and with posterior fossa radiation doses of 5200 rads or more. The posterior fossa was the common site of first relapse (in 56 @entity1 , 46%). Systemic @entity3 at first relapse occurred in 18 of 52 @entity1 (35%), and were associated with the use of ventriculosystemic shunts. Millipore filters did not prevent systemic relapse in shunted @entity1 . A subset of 15 @entity1 who received a posterior fossa dose of 5200 rads or more after a total resection had a 5-year survival rate of 77%, which remained constant to 10 years. This result is considered to be the upper limit that can be achieved by current treatment methods.
