Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal XXXX Treated With Radiation Therapy With Curative Intent.

@entity1 @entity4557 @entity66 @entity706 @entity1161 @entity1074 @entity204
PURPOSE: To report the long-term outcome and patterns of relapse of a large cohort of @entity1074 ( @entity1074 ) @entity1 treated with curative-intent @entity1161 ( @entity1161 ) alone. @entity1 AND METHODS: We reviewed the charts of 490 consecutive @entity1 with stage IE or IIE @entity1074 referred between 1992 and 2012 to our institution. Of those, 244 @entity1 (50%) were treated with @entity1161 alone. Pathology was confirmed by hematopathologists at our institution. @entity1 and disease factors were analyzed for association with @entity4557 ( @entity4557 ) and overall survival (OS). RESULTS: Median age of the cohort was 59  years, and median follow-up was 5.2  years. Ann Arbor stage was IE in 92%. Most common disease sites were stomach (50%), orbit (18%), non-thyroid head-and-neck (8%), skin (8%), and breast (5%). Median @entity1161 dose was 30  Gy. Five-year OS and @entity4557 were 92% and 74%, respectively. Cumulative incidence of @entity204 was just 1.1% by 5  years. Sixty @entity1 (24%) developed @entity66 ; 10 were in the @entity1161 field. Crude rate of transformation to pathologically confirmed @entity706 was 1.6%. On multivariable analysis, primary disease site (P=.007) was independently associated with @entity4557 , along with age (P=.04), presence of B-symptoms (P=.02), and International Prognostic Index risk group (P=.03). All disease sites except for head-and-neck had worse @entity4557 relative to stomach. CONCLUSION: Overall and cause-specific survival are high in early-stage extra-nodal @entity1074 treated with curative @entity1161 alone. In this large cohort of 244 @entity1 , most @entity1 did not experience relapse of @entity1074 after curative @entity1161 ; when relapses did occur, the majority were in distant sites. Stomach cases were less likely to relapse than other anatomic sites. @entity706 was rare.
