Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates @entity2438 Related Behaviors in BTBR XXXX .

@entity1 @entity9140 @entity19 @entity73 @entity2438 @entity72
UNASSIGNED: @entity72 ( @entity72 ) are characterized by social communication deficits, @entity73 , and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have a paracrine regenerative effect, and were speculated to be a potential therapy for @entity72 . The BTBR inbred @entity19 is a commonly used model of @entity72 as it demonstrates robust behavioral deficits consistent with the diagnostic criteria for @entity72 . BTBR @entity19 also exhibit decreased @entity9140 ( @entity9140 ) signaling and reduced hippocampal neurogenesis. In the current study, we evaluated the behavioral and molecular effects of intracerebroventricular  MSC transplantation in BTBR @entity19 . Transplantation of MSC resulted in a reduction of stereotypical behaviors, a decrease in @entity73 and an improvement in social behavior. Tissue analysis revealed elevated @entity9140 protein levels in the hippocampus accompanied by increased hippocampal neurogenesis in the MSC-transplanted @entity19 compared with sham treated @entity19 . This might indicate a possible mechanism underpinning the behavioral improvement. Our study suggests a novel therapeutic approach which may be translatable to @entity72 @entity1 in the future. @entity2438 Res 2015.    2015 International Society for @entity2438 Research, Wiley Periodicals, Inc.
