XXXX codon 72 polymorphism and the risk of @entity2 in a Korean population.

@entity1 @entity957 @entity2 @entity534 @entity876 @entity151 @entity420
The aim of this study was to assess whether @entity876 codon 72 polymorphism is associated with an increased risk of @entity2 ( @entity2 ) in a South Korean population. We conducted a population-based, large-scale, case-control study including 3939 @entity1 with @entity2 and 1700 controls. @entity876 codon 72 polymorphism was determined by real-time polymerase chain reaction (PCR). The frequencies of @entity876 codon 72 polymorphisms ( @entity534 / @entity534 , @entity534 /Pro, and Pro/Pro) in @entity2 were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01). The @entity534 /Pro and Pro/Pro genotype were significantly associated with increased risk of @entity2 (odds ratio (OR)=1.22, 95% confidence interval (CI)=1.06-1.14 and OR=1.83, 95% CI=1.48-2.26, respectively) compared with the @entity534 / @entity534 genotype. Risk was compared in different subgroups. The OR of Pro/Pro genotype was significantly higher in @entity151 ( @entity151 ) and @entity957 ( @entity957 ) than in @entity420 ( @entity420 ). Higher OR of Pro/Pro genotype was also seen among males. However, relationships between gender, age, smoking, and genotypes were not found. @entity876 codon 72 polymorphism was associated with an increased risk of @entity2 in this Korean population; the association was especially noteworthy in @entity957 , @entity151 , and males.
