Cumulative inflammatory burden is independently associated with increased arterial stiffness in XXXX with @entity5144 : a prospective study.

@entity1 @entity32 @entity5144 @entity65 @entity122 @entity1851
INTRODUCTION: The aim of this study was to examine whether the cumulative inflammatory burden is associated with an increase in arterial stiffness in a prospective cohort of @entity5144 ( @entity5144 ) @entity1 . METHODS: In total, 72 @entity5144 @entity1 were followed for a median of 6.5 years. Cumulative inflammatory burden was represented by the cumulative averages of repeated measures of erythrocyte sedimentation rate (ca-ESR) and @entity1851 (ca-CRP). Brachial-ankle pulse wave velocity ( @entity122 ) was measured at the last visit. We also included 47 healthy controls for @entity122 assessment. RESULTS: @entity122 was significantly higher in @entity5144 @entity1 compared with healthy controls after adjustment for age, gender and body weight (1466  29 cm/s versus 1323  38 cm/s, P=0.008). @entity5144 @entity1 were divided into two groups based on whether their @entity122 value is >= 1450 cm/s (High @entity122 group, N=38) or <1450 cm/s (Low @entity122 group, N=34). The High @entity122 group had a significantly higher ca-ESR (29 (19 to 44) versus 18 (10 to 32) mm/1st hour, P=0.005) and ca-CRP (0.7 (0.3 to 1.4) versus 0.4 (0.2 to 0.7) mg/dl, P=0.029). Using regression analysis, high ca-ESR (defined as >= 75th percentile: 37 mm/1st hour) was associated with a higher likelihood of being in the High @entity122 group (odds ratio (OR): 9.455 (1.939 to 46.093), P=0.005, adjusted for baseline clinical and cardiovascular risk factors; and 9.111 (1.875 to 44.275), P=0.006, adjusted for last visit parameters). CONCLUSIONS: Cumulative inflammatory burden, as reflected by ca-ESR, was associated with increased arterial stiffness in @entity5144 @entity1 even after adjustment for cardiovascular risk factors, emphasizing the important role of chronic @entity32 in accelerating the development of @entity65 in @entity5144 @entity1 .
