Neurodevelopmental outcomes of triplets or higher-order @entity600 XXXX .

@entity1 @entity245 @entity600 @entity2319 @entity1939 @entity306
BACKGROUND: @entity600 twins have a higher rate of @entity245 than singletons. Higher-order @entity600 multiple births may have an even higher rate of @entity245 . METHODS: @entity600 ( @entity600 401-1000 g) multiple births born in participating centers of the Neonatal Research Network between 1996 and 2005 were assessed for @entity245 at 18 to 22 months' corrected age. @entity245 was defined by the presence of 1 or more of the following: moderate to severe @entity306 ; mental developmental index score or psychomotor developmental index score less than 70; severe @entity2319 ; or @entity1939 . @entity1 who died within 12 hours of birth were excluded. Maternal and @entity1 demographic and clinical variables were compared among singleton, twin, and triplet or higher-order @entity1 . Logistic regression analysis was performed to establish the association between singletons, twins, and triplet or higher-order multiples and @entity245 , controlling for confounding variables that may affect @entity245 . RESULTS: Our cohort consisted of 8296 singleton, 2164 twin, and 521 triplet or higher-order @entity1 . The risk of @entity245 was increased in triplets or higher-order multiples when compared with singletons (adjusted odds ratio: 1.7 [95% confidence interval: 1.29-2.24]), and there was a trend toward an increased risk when compared with twins (adjusted odds ratio: 1.27 [95% confidence: 0.95-1.71]). CONCLUSIONS: Triplet or higher-order births are associated with an increased risk of @entity245 at 18 to 22 months' corrected age when compared with @entity600 singleton @entity1 , and there was a trend toward an increased risk when compared with twins.
