Pressure-dependent @entity1122 release: the kidney factor in long-term control of arterial blood pressure in conscious XXXX .

@entity101 @entity235 @entity1372 @entity38911 @entity1122 @entity73186
In 12 conscious @entity235 on a normal @entity1372 diet the renal venous-arterial plasma @entity1122 activity-difference as a function of mean renal artery pressure ( @entity1122 stimulus-response curve; RSRC) as well as long-term mean arterial blood pressure (MAP; pressure-histograms) were measured repeatedly. The RSRC @entity73186 ) a threshold pressure ( @entity38911 ), 2) a flat section above @entity38911 (plateau-level), and 3) a steep slope below @entity38911 . From @entity235 to @entity235 the slope varied from -0.20 to -0.54 ng AI/ml/h/mmHg and @entity38911 from 78.4 to 107.1 mmHg. In every @entity235 MAP was higher than @entity38911 (MAP- @entity38911 :12.8 +/- 1.58 mmHg). @entity235 with a higher @entity38911 regularly showed a higher MAP (r = 0.76; P less than 0.005). Due to its normal variability arterial pressure occasionally falls below @entity38911 and thus causes @entity1122 release. Therefore MAP will stabilize at a level above @entity38911 . The pressor effect (MAP- @entity38911 ) of this feedback system should depend on the sensitivity of the pressure-dependent @entity1122 release mechanism (slope of RSRC). Accordingly we observed a close correlation between the slope of the RSRC and the MAP- @entity38911 difference (r = 0.93; P less than 0.0001). We conclude that in healthy @entity235 the level of long-term blood pressure can be explained almost completely by @entity38911 and the slope of the pressure-dependent @entity1122 release. Our findings may offer new perspectives to the pathogenesis of @entity101 .
