Serum Level of Matrix Metalloproteinase-2 and -9 in @entity1 with XXXX and Clinical Significance.

@entity1 @entity1476 @entity5 @entity957 @entity1495
BACKGROUND: @entity5 is an important malignancy in head and neck area and @entity957 ( @entity957 ) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different @entity5 and their correlation with @entity5 invasiveness has been documented. However, most studies have evaluated @entity1476 and @entity1495 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in @entity1 with laryngeal @entity957 compared to normal subjects and assess any relation with @entity5 clinicopathological findings. MATERIALS AND METHODS: In this case control study, 20 @entity1 with oral @entity957 and 20 healthy subjects were included. Serum levels of @entity1476 and @entity1495 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. RESULTS: @entity1 with laryngeal @entity957 had significantly higher serum levels of @entity1476 (p=0.01) and @entity1495 (p=0.03) compared to healthy subjects. @entity1 with higher T stage (T3,4) had significantly higher @entity1476 (p=0.04) and @entity1495 (p=0.01). There was significant positive correlation between serum levels of @entity1476 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of @entity1495 with T stage (r=0.527, p=0.01). CONCLUSIONS: Our results showed that compared to healthy subjects, both @entity1476 and @entity1495 are significantly increased in serum of laryngeal @entity957 cases. @entity1476 was correlated with lymph node involvement while @entity1495 has stronger correlation with T stage compared to @entity1476 .
