Growth, body composition, and endocrine responses to chronic administration of insulin-like growth factor I and(or) porcine growth hormone in XXXX .

@entity1707 @entity10850
The actions of @entity10850 , alone and in combination with porcine growth hormone (pGH), on growth and circulating endocrines and metabolites important in growth were investigated in peripubertal-age Meishan barrows. @entity1707 were assigned to four treatments: control, buffer; @entity10850 , 33 microg rhIGF-I/kg BW injected twice daily; pGH, 33 microg rpGH/kg BW injected once daily; and @entity10850 +pGH, 33 microg rhIGF-I/kg BW injected twice daily plus 33 microg rpGH/kg BW injected once daily. Treatments were administered for 28 d. Feed intake, BW, and backfat were recorded and blood samples were collected weekly. At slaughter, organ and primal cut weights were recorded. Offal and half the carcass were ground for chemical analysis. Serum concentrations of @entity10850 on d 7, 14, 21, and 28 in the @entity10850 , pGH, and @entity10850 +pGH groups were increased 60, 107, and 131%, respectively, compared with those of the control group. Administration of pGH increased gain 43%, feed efficiency 60%, carcass protein accretion 88%, and trimmed lean cuts 16%, whereas @entity10850 administration increased gain 22%, carcass protein accretion 33%, and trimmed lean cuts 5%. There was little difference in responses to administration of @entity10850 +pGH and pGH alone except that coadministration of @entity10850 with pGH reduced the ability of pGH to suppress backfat gain (P < .02). Even though administration of @entity10850 resulted in a 60% increase in chronic nadir serum concentrations of @entity10850 , only a few growth and carcass measures were changed when compared with control @entity1707 . These included increased (P < .05) weight of body, leaf fat, kidneys, and belly. The actions of pGH on growth of @entity1707 were not mimicked, and some were countermanded by administration of @entity10850 at a dose that produces significantly increased serum concentrations of @entity10850 .
