The DORNROSCHEN/ENHANCER OF SHOOT REGENERATION1 gene of XXXX acts in the control of meristem ccll fate and lateral organ development.

@entity958 @entity30456 @entity30457 @entity72607 @entity30387
The two main tasks of a meristem, self-perpetuation and organ initiation, are separated spatially. Slowly dividing cells in the meristem center act as pluripotent stem cells, and only their derivatives in the meristem periphery specify new organs. Meristem integrity and cellular proliferation are controlled in part by regulatory interactions between genes that are expressed in specific subdomains of the meristem. Using transposon-mediated activation tagging, we have identified Dornr  schen ( @entity72607 -D) mutants of @entity958 that prematurely arrest shoot meristem activity with the formation of radialized lateral organs. The mutated gene ( @entity72607 / @entity72607 ), which encodes an @entity30387 /ERF protein, is expressed in a subdomain of meristem stem cells, in lateral organ anlagen, and transiently in the distal domain of organ primordia. During the development of @entity72607 -D mutants, expression of the homeobox gene SHOOTMERISTEMLESS is downregulated and later reactivated in an altered domain. In addition, we found increased expression of @entity30457 and @entity30456 , two genes that antagonistically regulate stem cell fate in meristems. These findings suggest that the @entity72607 / @entity72607 gene product is involved in the regulation of gene expression patterns in meristems. Furthermore, specific misexpression of @entity72607 in meristem stem cells affects organ polarity and outgrowth in the meristem periphery, indicating that @entity72607 / @entity72607 itself, or a process regulated by @entity72607 / @entity72607 , can act non-cell-autonomously. We elaborate on the role of @entity72607 / @entity72607 in meristem and organ development and discuss its possible role in the process of shoot regeneration.
