Dose-dependent effect of @entity12165 cross-linked hemoglobin on regional blood circulation of severely hemorrhaged XXXX .

@entity64 @entity548 @entity12165 @entity26 @entity4774 @entity177 @entity12166 @entity880 @entity35
@entity12165 cross-linked hemoglobin ( @entity12166 ), a hemoglobin-based blood substitute, has been found to improve systemic hemodynamics, cutaneous @entity26 tension, and normalization of blood @entity880 levels and acid-base equilibrium after @entity548 in animals. The present study was conducted to determine the dose-dependent effect of a 10% solution of @entity12166 (20, 50, and 100% of shed blood volume; SBV) on regional blood circulation in hemorrhaged @entity35 . @entity548 was induced in @entity4774 -anesthetized @entity35 by bleeding them at a rate of approximately .5 to 1 mL/min until a mean arterial pressure of 35-40 mmHg was achieved. This was maintained for up to 90 min to reach a base deficit of more than -12 mmol/L. @entity548 significantly decreased @entity26 consumption, mean arterial pressure, cardiac output, @entity64 volume, and regional blood circulation, but increased total peripheral resistance. The vehicle Ringer's @entity880 (RL at 20% of SBV, intravenously) did not produce any improvements in @entity26 consumption, base deficit, systemic hemodynamics, and regional blood circulation. @entity12166 increased @entity26 consumption, decreased base deficit, and produced significant improvements in systemic hemodynamics and regional blood flow in a dose-dependent manner. The increase in blood flow was highly significant until 60 min, but was less marked at 120 min, after resuscitation with @entity12166 . Resuscitation with RL (300% of SBV) significantly improved systemic and regional blood circulation. However, the improvement was greater after resuscitation with @entity12166 (50 or 100% of SBV) as compared with RL at 300% SBV. @entity12166 in the dose of 50% of SBV produced maximal resuscitative effects, which were comparable to a @entity12166 dose of 100% of SBV. The effect of @entity12166 at 50% of SBV on renal cortical blood perfusion, concentration of moving red blood cells (CMBC), and blood velocity was also studied using laser Doppler flowmetry. @entity548 produced a @entity177 (85.3%), which was due to a decrease in the CMBC (61.0%) and their velocity (64.2%). Resuscitation with the RL did not produce any improvement in renal cortical perfusion. However, resuscitation with @entity12166 significantly increased renal cortical perfusion (364.7%) due to an increase in both CMBC (123.4%) and their velocity (109.9%). It is concluded that @entity12166 in a dose of 50% of SBV produces maximal improvement in regional blood circulation of hemorrhaged @entity35 .
