Evaluation of the analgesic efficacy of local XXXX application.

@entity1 @entity26 @entity281 @entity158 @entity6948
OBJECTIVES: To determine the analgesic effects of locally applied @entity6948 in third molar surgery under general anesthesia. METHODS: @entity1 undergoing bilateral third molar surgery under general anesthesia were recruited into this double-blind, randomized, controlled study and were allocated to 3 study groups. Group D received preincision intravenous @entity6948 (1 mcg/kg) and direct infiltration of normal saline to the surgical wounds at the end of the surgery. Group P received preincision intravenous normal saline and direct infiltration of @entity6948 (1  g /kg) to the surgical wounds at the end of the surgery. A control group (group N) received normal saline at both time points. Postoperative analgesic effects, analgesic consumption, @entity158 satisfaction score, vital signs, adverse events, and postoperative recovery were assessed. RESULTS: Thirty-three @entity1 from each group were studied. Postoperative resting @entity158 numerical rating scale scores were similar in all the groups. However, the areas under curves of numerical rating scale @entity158 scores during mouth opening for 1 to 72 hours were significantly lower in group P than in group N (P=0.012). Both heart rate and systolic blood pressure in the immediate postoperative period were significantly lower in groups D and P than in group N (P<0.001). @entity1 from groups D and P were also more sedated than @entity1 in group N (P=0.013 and P=0.007, respectively) but no difference in psychomotor recovery was observed. Respiratory rate, @entity26 saturation, common side effects, wound @entity281 rate, and @entity158 satisfaction scores were similar among the groups. CONCLUSIONS: @entity6948 seems to have an antihyperalgesic effect when administered locally after bilateral third molar surgery. There is no delay in psychomotor recovery or increase in postoperative clinically significant adverse events.
