Resistance Training and White Matter Lesion Progression in Older XXXX : Exploratory Analysis of a 12-Month Randomized Controlled Trial.

@entity1 @entity62 @entity3013
OBJECTIVES: To assess whether @entity3013 ( @entity3013 ) slows the progression of @entity62 ( @entity62 ) in older @entity1 . DESIGN: Secondary analysis of a 52-week randomized controlled trial of @entity3013 , the Brain Power Study. SETTING: Community center and research center. @entity1 : Of 155 community-dwelling @entity1 aged 65 to 75 enrolled in the Brain Power Study, 54 who had evidence of @entity62 on magnetic resonance imaging (MRI) at baseline were included in this secondary analysis. INTERVENTION: @entity1 were randomized to once-weekly @entity3013 (1* @entity3013 ), twice-weekly @entity3013 (2* @entity3013 ), or twice-weekly balance and tone (BAT). Assessors were blinded to @entity1 assignments. MEASUREMENTS: WML volume was measured using MRI at baseline and trial completion. RESULTS: At trial completion, the 2* @entity3013 group had significantly lower WML volume than the BAT group (P  =  .03). There was no significant difference between the BAT group and the 1* @entity3013 group at trial completion (P  =  .77). Among @entity1 in the two @entity3013 groups, reduced WML progression over 12  months was significantly associated with maintenance of gait speed (correlation coefficient (r)  =  -0.31, P  =  .049) but not with executive functions (r  =  0.30; P  =  .06). CONCLUSION: Engaging in progressive @entity3013 may reduce WML progression.
