Abnormal nerve regeneration in @entity3649 XXXX .

@entity527 @entity16 @entity3986 @entity3949 @entity1346 @entity3649 @entity35
Nerve regeneration across a 10 mm gap through an implanted @entity1346 tube was delayed in @entity3649 -fed @entity35 two and four weeks after transecting the nerve. This experimental metabolic @entity16 resembles @entity3949 in which nerve regeneration is also delayed. Experiments were performed by introducing opposite ends of divided sciatic nerves into close-fitting @entity1346 tubes, leaving a 10 mm gap. Growth of @entity527 across this gap was monitored by electron microscopy performed in sections at regular intervals of 2 mm from proximal to distal stumps. After two weeks some difference was apparent; axons advanced 1.4 +/- 0.4 mm in @entity3649 -fed @entity35 versus 3.5 +/- 1.5 mm in controls. Myelination did not progress beyond 1 mm in @entity3649 -fed @entity35 . Differences were greater between the two groups at four weeks. The growth of axons in @entity3649 @entity35 was 3.5 +/- 0.2 mm versus 9.4 +/- 0.1 mm in control nerves. In addition the size of the regenerating stump was much greater in control @entity35 . Qualitative differences were also noticed during electron microscopic comparison of control and @entity3649 -treated @entity35 . The @entity3986 seen in treated @entity35 had abnormal electron-dense organelles, lamellated bodies, vesicles and tubular structures, as well as numerous glycogen granules. Abnormalities of spatial orientation were also noted. Unlike control axons which grew parallel with the long axis of the tube, regenerating axons in experimental animals were seen deviating from the axis at 90 degrees angles. Both immature sprouts and myelinating axons showed abnormal plasticity. Ultrastructural differences were also noted in Schwann cells, macrophages and vessels.
