Conversion from XXXX to @entity205 in @entity1 with new-onset @entity6 after renal transplant: an open-label randomized prospective pilot study.

@entity4051 @entity9472 @entity1 @entity6 @entity205 @entity281 @entity1017 @entity56 @entity5467 @entity1140 @entity413
BACKGROUND: New-onset @entity6 after transplant (NODAT) is associated with serious morbidity and mortality. The incidence of NODAT is higher with @entity1140 ( @entity5467 ) compared with @entity205 ( @entity9472 ); however, the effects of switching from @entity5467 to @entity9472 in NODAT have not been studied well. MATERIALS AND METHODS: This was a single-center, open-label, prospective, randomized study, including renal transplant recipients who were on @entity5467 -based immunosuppression and developed NODAT. Those with pretransplant @entity6 , @entity56 to @entity9472 or @entity5467 , severe @entity281 , and denying consent were excluded. Subjects were randomized to either switch to @entity9472 or to continue on @entity5467 . Fasting and postprandial plasma @entity413 , fasting insulin and C-peptide levels, insulin and oral hypoglycaemic agents (OHA) use were monitored monthly for 3 months, whereas glycosylated haemoglobin (HbA1c) was checked at baseline and 3 months. RESULTS: Sixty-seven subjects were randomized to switch to @entity9472 (n  = 32) or continuation of @entity5467 (n  = 35). Both groups had similar baseline characteristics. After randomization, there was significant improvement in fasting plasma @entity413 , fasting insulin levels, C-peptide levels, and insulin requirement in both groups, whereas @entity4051 c improved significantly only in the @entity9472 group. The decline in fasting plasma @entity413 and insulin requirement was more significant in subjects on @entity9472 . An equal number of subjects in each group (59.4% in @entity9472 group and 40% in @entity5467 group, P  = ns) had resolution of NODAT. @entity1017 was more significant in the @entity9472 group; however, there was no difference in other side effects or rejection episodes. CONCLUSIONS: A switch from @entity1140 to @entity205 is a safe and effective strategy in @entity1 with NODAT.
