Scintigraphy Demonstrates High Rate of False-positive Results From XXXX Breath Tests for Small Bowel @entity6124 .

@entity1 @entity3884 @entity1353 @entity577 @entity6124 @entity694 @entity413
BACKGROUND _ AIMS: Breath tests for @entity3884 and/or @entity577 are used to detect small bowel @entity6124 (SBBO), but false-positive results can arise from clinical conditions that accelerate small bowel transit and deliver unabsorbed @entity413 to the colon. We investigated the prevalence of false-positive results from @entity413 breath tests by also evaluating @entity1 with scintigraphy. METHODS: In a retrospective study, we reviewed data from @entity413 breath tests performed with concurrent scintigraphy on 139 @entity1 with suspected SBBO at the Medical College of Wisconsin from January 2003 through July 2013. Results from breath tests were considered abnormal (positive) if there was an increasing curve of @entity3884 or @entity577 by >15 parts per million above baseline within 90 minutes. Scintigraphy was used to determine whether this increase occurred before or after the @entity413 bolus arrived at the cecum. Data from a subset of 45 @entity1 with prior upper gastrointestinal surgery were analyzed separately. RESULTS: Forty-six of the @entity1 (33%) had abnormal results from breath tests. On the basis of scintigraphy findings, 22 of these @entity1 (48%) had false-positive results, which were caused by colon fermentation of unabsorbed @entity413 . Colon fermentation caused false-positive results in 65% of @entity1 who had undergone upper gastrointestinal surgery and 13% of @entity1 without prior surgery. @entity1 with false-positive results caused by @entity694 had shorter mean oro-cecal transit times (18 minutes) compared with @entity1 with positive breath-test results because of SBBO (79 minutes) or negative results (86 minutes). CONCLUSIONS: Almost half of positive results from @entity413 breath tests are false because of @entity694 . All @entity1 with abnormal results from breath tests should be considered for @entity1353 testing with concurrent scintigraphy to distinguish SBBO from @entity694 . Most @entity1 who have undergone upper gastrointestinal surgery have abnormal results from breath tests and should be assessed by using concurrent scintigraphy with the initial breath test.
