@entity3009 -independent protection by XXXX from oliguric @entity177 in conscious @entity35 .

@entity8 @entity972 @entity63 @entity1421 @entity1372 @entity1483 @entity3009 @entity177 @entity432 @entity1011 @entity35 @entity3352
In 38 conscious @entity35 divided into seven groups, acute unilateral @entity177 was induced by 1 hour of @entity432 while the contralateral kidney remained intact. @entity8 was monitored up to 144 hours after @entity63 and revealed a typical course of @entity177 with oligoanuria persisting for more than 48 hours. Urinary osmolality and @entity1372 concentration became plasma isotonic after release of @entity432 and approximated control values on day 6 after @entity63 . In nine @entity35 , the i.v. infusion of @entity1483 before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) @entity432 protected the @entity63 kidney from oligoanuria with endogenous @entity1011 clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after @entity63 . Tubular absorption of @entity1372 and water was at least partially preserved 36 hours after @entity63 when infusion of @entity1483 was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary @entity3009 (PG) E2 excretion before and after @entity432 ; and 5 hours after @entity63 , @entity1421 excretion from the @entity63 kidney significantly exceeded that from the intact kidney (P less than 0.05). @entity3352 (1 mg/100 g body wt) administered in six animals markedly suppressed control @entity1421 excretion (P less than 0.05) as well as the @entity1483 -induced rise in urinary PG excretion before and after @entity63 but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and @entity1372 and @entity972 excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in @entity1011 clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of @entity1483 in acute @entity177 .
