Whole-grain and fiber intake and the incidence of XXXX 2 @entity6 .

@entity1 @entity164 @entity6
BACKGROUND: Epidemiologic evidence of a preventive effect of whole grain against @entity164 2 @entity6 is mainly based on data from @entity1 . Information specific to @entity1 and @entity1 is needed. OBJECTIVE: The objective was to study the relation between the intake of whole grain and fiber and the subsequent incidence of @entity164 2 @entity6 . DESIGN: The design was a cohort study of 2286 @entity1 and 2030 @entity1 aged 40-69 y and initially free of @entity6 . Food consumption data were collected from 1966 through 1972 with the use of a dietary history interview covering the habitual diet during the previous year. During a 10-y follow-up, incident @entity164 2 @entity6 cases were identified in 54 @entity1 and 102 @entity1 from a nationwide register. RESULTS: Whole-grain consumption was associated with a reduced risk of @entity164 2 @entity6 . The relative risk (adjusted for age, sex, geographic area, smoking status, body mass index, energy intake, and intakes of vegetables, fruit, and berries) between the highest and lowest quartiles of whole-grain consumption was 0.65 (95% CI: 0.36, 1.18; P for trend = 0.02). Cereal fiber intake was also associated with a reduced risk of @entity164 2 @entity6 . The relative risk between the extreme quartiles of cereal fiber intake was 0.39 (95% CI: 0.20, 0.77; P = 0.01). CONCLUSIONS: An inverse association between whole-grain intake and the risk of @entity164 2 @entity6 was found. The similar result for cereal fiber intake suggests that the whole-grain association is due to cereal fiber or another factor related to cereal fiber intake.
