Markers of @entity1593 and @entity1593 in XXXX .

@entity1 @entity162 @entity1593 @entity146 @entity161 @entity8265
OBJECTIVES: Increased immune sensitivity to dietary gluten proteins has been reported in @entity161 but has not been studied in @entity162 . In this study, we examine the levels of antibody reactivity to gliadin, deamidated gliadin, and @entity8265 ( @entity8265 ) in individuals with @entity162 and compare these levels to those in individuals who do not have any history of @entity146 . METHODS: The sample of 275 individuals included 102 with @entity162 and 173 controls without a @entity146 . Immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies to gliadin and @entity8265 and IgG antibodies to deamidated gliadin were measured by enzyme immunoassay. @entity1 ' levels of antibodies to deamidated gliadin and @entity8265 were classified based on the cutoffs for positivity that are predictive of @entity1593 . Quantitative levels of antibodies were compared between groups employing regression models which were controlled for demographic variables. RESULTS: Individuals with @entity162 had increased levels of IgG antibodies to gliadin compared with controls in multivariate analyses. We also found evidence of increased levels of antibodies to deamidated gliadin in the @entity162 population. The levels of IgA class antigliadin antibodies and antibodies to @entity8265 did not differ significantly between groups. There was also not a significant difference between groups in the number of @entity1 who were classified as having levels of antibodies to deamidated gliadin or @entity8265 that are predictive of @entity1593 . CONCLUSIONS: Individuals with @entity162 have increased levels of IgG antibodies to gliadin. However, such antibody increase is not accompanied by an elevation in IgA antibodies to gliadin or the @entity1593 -associated antibodies against deamidated gliadin and @entity8265 . These results warrant further detailed examination of the molecular specificity and pattern of reactivity of the antibody response to gluten antigens in @entity162 .
