Use of non-invasive cardiac investigations to predict clinical endpoints after coronary bypass graft surgery in coronary artery disease XXXX : results from the prognosis and evaluation of risk in the coronary operated @entity1 (PERISCOP) study.

@entity1 @entity64 @entity712 @entity308 @entity951 @entity583 @entity204 @entity65 @entity1002
AIMS: Little is known about which @entity1 who have undergone coronary bypass surgery are at risk of future clinical @entity65 and may benefit from further medical treatment. We sought to determine if routine non-invasive cardiac investigations performed early after surgery were able to stratify the risk of @entity65 in this population. METHODS: Two thousand and sixty-five consecutive @entity1 were enrolled in a prospective multicenter study (PERISCOP). Exercise testing, echocardiography, and 24-h ambulatory ECG monitoring were performed at day 20+/-10 after coronary bypass surgery. Follow-up was performed 1 year after coronary bypass surgery. Causes of all hospitalisation and death occurring within 1 year were documented and classified by an End-point Committee. The principal endpoint was the combination of all-cause @entity204 and @entity65 requiring hospitalisation ( @entity583 , unstable or severe @entity951 , @entity64 , @entity712 ). RESULTS: The 1-year frequency of first events was 155 (8%). In multivariate analysis, exercise duration <420s (RR=1.68; 95% CI: 1.13-2.49), exercise induced @entity308 >1mm (RR=1.90; 95% CI: 1.18-3.05), and @entity1002 (wall motion index <1.15) (RR=1.97; 95% CI: 1.10-3.51) were independent predictors of @entity65 and @entity204 . Ambulatory ECG monitoring had no predictive value. CONCLUSIONS: Exercise testing and echocardiography performed early after coronary bypass surgery are able to identify high-risk @entity1 who may benefit from intensive secondary prevention.
