Newborn XXXX screening: the Jamaican experience (1995-2006).

@entity1 @entity18697 @entity3458 @entity5837
OBJECTIVES: The aim of this study was to evaluate the existing newborn sickle haemoglobinopathy screening programme in Jamaica. METHODS: A retrospective analysis of @entity1 screened during the period 8 November 1995 to 22 July 2006 was performed. @entity1 data for analyses was restricted to @entity1 with homozygous ( @entity3458 ) @entity3458 . Published data from the Jamaican Sickle Cell Cohort Study was used to make comparisons with the study sample. RESULTS: The study sample consisted of 435 @entity1 with @entity3458 . @entity5837 was the most common clinical (non-death) event accounting for approximately 50% of all events. Acute @entity18697 , no longer a significant cause of mortality, was responsible for approximately 32% of clinical events. Seven deaths (1.8%) occurred during the study period compared with 17.6% to the same age in the Jamaican Sickle Cell Cohort Study. There was a lower proportion of hospital admissions and episodes of serious illness in the study group compared with controls. CONCLUSIONS: Survival estimates for the study sample showed improvement compared with the Jamaican Sickle Cell Cohort Study. This study continues to demonstrate the benefits of, and as such shows support for, newborn screening and early interventions in @entity3458 . In addition, it highlights some of the areas for continued focus and research development. Although the current system is providing an essential and beneficial service, the study emphasizes the need for newborn screening programmes to be comprehensive care systems to be fully effective.
