An overview of species differences in the effects of a water extract of XXXX bract on isolated airway smooth muscle, and effects of @entity526 lipopolysaccharide.

@entity859 @entity2708 @entity235 @entity526 @entity840 @entity750 @entity112 @entity3044 @entity3312 @entity2710 @entity4338 @entity855
Our laboratory has been comparing the activity of a water extract of @entity2708 bract (CBE) with the isolated trachealis smooth muscle of the @entity235 , @entity840 , and cat. CBE induced contractions that were not mediated by @entity750 ( @entity750 ), @entity112 , or muscarinic receptors. The active agent(s) in CBE was dialyzable (less than 14,000 molecular weight), and substantial activity was retained after low-temperature ashing. CBE potentiated contractions of @entity235 trachealis to @entity112 and @entity750 and relaxation responses to @entity3044 , whereas it had no effect on responses to @entity2710 and @entity4338 . In the @entity840 trachealis, CBE reduced responsiveness to @entity4338 , potentiated relaxations to @entity859 and @entity855 , and did not alter the responses to the remaining agents. Responses of cat trachealis to @entity4338 and @entity3044 were potentiated by CBE, while those to @entity750 were unaffected. Neurogenic cholinergic contractile responses were potentiated by CBE in the trachealis of the @entity235 , but not of the @entity840 , while neurogenic relaxations were potentiated by CBE in @entity840 trachealis but not in the @entity235 trachealis. There are thus marked species differences in the acute effects of CBE on airway smooth muscle. Due to recent interest in the possible involvement of bacterial endotoxins in the etiology of @entity3312 , we examined the effects of @entity526 lipopolysaccharide (LPS) in @entity840 trachealis. An initial examination revealed that LPS potentiated responses to @entity112 , but not those to @entity2710 and @entity3044 . This effect vanished upon a second appraisal with a different batch of LPS. The effect of LPS in airway smooth muscle is thus, at present, equivocal.
