Factors associated with XXXX after living donor hepatectomy.

@entity1 @entity648 @entity3638
PURPOSE: Increased serum @entity648 levels are common after living-donor hepatectomy. Little information is available on the characteristics and clinical significance of serum @entity648 levels soon after donor hepatectomy. MATERIALS AND METHODS: Since September 2001, we performed 229 living donor hepatectomies for living-donor liver transplantations. The 128 @entity1 and 101 @entity1 had a mean age of 34.4  8.9 years (range, 19-66). Most donors were parents (n=110; 48%). We transplanted 110 right lobes, 46 left lobes, and 73 left lateral segments. Donors were divided into 2 groups: Group 1 consisted of 181 donors who showed total @entity648 levels of <3 mg/dL, and group 2, 48 donors with levels of >= 3 mg/dL on postoperative day 3. Preoperative total @entity648 level, ratio of preoperatively estimated remnant liver volume, surgical duration, gender, age, graft type, blood transfusions, and preoperative liver biopsy findings were evaluated as risk factors for @entity3638 . RESULTS: The mean postoperative maximum total @entity648 level was 2.26  1.49 mg/dL (range, 0.36-9.9). Remnant liver volume<40%, preoperative @entity648 levels>1 mg/dL, right lobe donor hepatectomy, male donor, and abnormal liver biopsy findings were significant risk factors for postoperative @entity3638 (P=.015, P=.02, P<.01, P=.008, and P=.023 respectively). Also donor age>50 years showed a slight effect on @entity3638 (P=.052). Blood transfusions and surgical times were not significant factors. CONCLUSION: Donor safety is paramount, requiring thorough donor evaluation. Extensive liver resection may result in transient functional impairment. Several factors are believed to play roles in the development of postoperative @entity3638 after living-donor hepatectomy.
