The effects of long term XXXX administration on insulin secretion and insulin sensitivity.

@entity6 @entity2690 @entity23375 @entity1720 @entity413
@entity23375 (80 mg bd) was administered to nine subjects with type 2 (non insulin dependent) @entity6 inadequately controlled on diet only. Twenty-four hour @entity413 , insulin and @entity2690 profiles were obtained before and after one week and four months of therapy. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp before and after four months of treatment. Twenty-four hour @entity413 levels were significantly lowered after one week and four months. Insulin secretion, as assessed by the areas under the insulin and @entity2690 curves, was enhanced after one week. The increase was most noted during the day in response to meals. The enhancement was maintained after four months of treatment with the increase in the postabsorptive phase becoming significant. @entity413 utilisation rate was significantly increased at four months. It is concluded that both acute and prolonged @entity23375 therapy directly or indirectly 1) enhances both meal stimulated and post absorptive insulin secretion and 2) @entity1720 . The relative contribution of each to improved diabetic control has not been established.
