Full-thickness biopsy of the jejunum reveals XXXX and enteric neuropathy in @entity1744 .

@entity1 @entity32 @entity29 @entity179 @entity2513 @entity1744 @entity528
BACKGROUND _ AIMS: @entity1744 ( @entity1744 ) is regarded as a @entity29 . Few studies have looked for histopathologic changes in the gut and only then in biopsy specimens from intestinal mucosa. Because bowel function is governed mainly by nerve plexuses in the bowel wall, we have investigated full-thickness bowel biopsy specimens in @entity1 with severe @entity1744 . METHODS: We used a laparoscopy-assisted technique to obtain full-thickness biopsy specimens from the proximal jejunum. Tissue specimens were investigated with light microscopy using routine stainings and immunohistochemical techniques. Horizontal sectioning was done to visualize large areas of the myenteric plexus. Fifteen autopsy specimens were used as controls regarding the myenteric plexus. @entity2513 controls with terminal ileum biopsy specimens and full-thickness jejunal biopsy specimens from @entity1 with @entity179 were used as control groups for intraepithelial lymphocyte counts. RESULTS: Ten @entity1 (2 males, 8 females) were studied. In 9 @entity1 , we found low-grade infiltration of lymphocytes in the myenteric plexus. Lymphocytes had peri- and intraganglionic location. The mean number of lymphocytes per ganglion ranged from 1.9 to 7.1 per @entity1 , with an overall mean of 3.4. No intraganglionic lymphocytes were found in the control group and only a few periganglionic lymphocytes (mean, 0.2). Four @entity1 had concomitant intraepithelial lymphocytosis. @entity528 was evident in 6 of 9 @entity1 with and 1 @entity1 without ganglionic lymphocyte infiltration. CONCLUSIONS: Our findings indicate that @entity32 and @entity528 in the myenteric plexus are involved in the pathogenesis of @entity1744 .
