Differentiation of viable and nonviable myocardium after acute reperfusion using serial XXXX -201 imaging.

@entity235 @entity168 @entity4214 @entity1188
This study was performed to determine if differences in regional myocardial @entity4214 clearance rates could differentiate salvaged from nonsalvaged myocardium after reperfusion. Twenty-one @entity235 underwent 2 hours of left anterior descending coronary artery ligation followed by reperfusion. @entity4214 was administered 5 minutes later and serial images were acquired over 3 hours. Of the 21 @entity235 , 15 had @entity1188 of which nine had initially reduced anterior wall @entity4214 activity (group 1) and six had normal or increased activity (group 2). Six @entity235 did not have an @entity1188 (group 3). All group 1 @entity235 demonstrated reduced clearance rates in the anterior wall (T1/2 = 15.0 +/- 4.7 hours, @entity168 ) compared to the posterior wall (T1/2 = 9.0 +/- 4.4 hours; p less than 0.001). Group 2 @entity235 demonstrated increased clearance rates in the anterior wall (T1/2 = 5.7 +/- 2.0 hours) compared to the posterior wall (T1/2 = 10.5 +/- 4.6 hours; p less than 0.001). Group 3 @entity235 demonstrated no difference in clearance rates. In conclusion, although @entity4214 uptake is frequently reduced in nonsalvaged myocardium, tracer uptake can be normal or increased if perfusion has been completely restored. However, an increased clearance rate from the reperfused zone compared to the normal zone is a reliable indicator of nonsalvaged myocardium, despite normal initial @entity4214 uptake.
