XXXX of the head and neck: Demographics, clinicopathologic features, management, and treatment outcomes.

@entity1 @entity808 @entity66 @entity3012 @entity5 @entity3
OBJECTIVES: To determine the epidemiology and prognostic indicators in @entity1 with @entity808 ( @entity808 ) of the head and neck. MATERIALS AND METHODS: The surveillance, epidemiology, and end results registry was reviewed for @entity1 with head and neck @entity808 from 1973 to 2011. Study variables included age, sex, race, @entity5 size, stage at presentation, and treatment modality. RESULTS: There were 374 cases of head and neck @entity808 identified. Mean age at diagnosis was 50.7years; 60.2% of @entity1 were male and 82.6% were white. After diagnosis, 38.8% of @entity1 underwent surgery and radiation therapy and 48.1% underwent surgery alone. Kaplan-Meier analysis demonstrated overall ( @entity3012 ) and @entity66 ( @entity66 ) of 51% and 67% at 5years. Multivariate Cox regression analysis showed that age (p=0.030), stage (p=0.002), surgery (p=0.037), and size (p<0.001) were predictors of @entity3012 , while stage (p<0.001) and size (p<0.001) were predictors of @entity66 . For @entity5 , surgery (p=0.011) and size (p=0.010) were predictors of @entity3012 , and size (p=0.001) predicted @entity66 . For stage III/IV @entity5 , both radiotherapy (p=0.024, p=0.009) and size (p=0.001, p=0.001) predicted @entity3012 and @entity66 . For @entity5    5cm, stage (p=0.031) predicted @entity66 . For @entity5 >5cm, male gender (p=0.005), stage (p=0.001), surgery (p=0.003), and radiotherapy (p=0.050) were determinants of @entity3012 , and male gender (p=0.022), stage (p<0.001), and radiotherapy (p=0.002) were determinants of @entity66 . CONCLUSION: Surgical resection confers survival benefit in @entity1 with early stage @entity808 , while radiotherapy improves survival in cases with @entity3 . Surgery and radiotherapy are prognostically important in @entity1 with @entity5 >5cm.
