[Diagnostic and prognostic values of repair protein @entity6756 , XXXX and protein @entity2280 immunoexpression in sporadic @entity14 ].

@entity1 @entity6756 @entity5 @entity344 @entity4311 @entity14 @entity2280 @entity420
@entity14 is the most common @entity344 in the world. The survival of @entity1 with @entity14 has not varied appreciably in recent years. The knowledge that genetic factors could play a role in the etiology and prognosis of @entity1 with sporadic @entity14 has opened up new lines of research. The aim of the study was to evaluate a group of @entity1 with @entity14 and the possible influence on the prognosis of immunohistochemical @entity6756 , @entity4311 and @entity2280 expression. MATERIAL AND METHODS: 37 cases of @entity14 were included in this study. @entity6756 , @entity4311 and @entity2280 protein expression in @entity5 tissue sections was determined using immunohistochemical staining with specific monoclonal antibodies. A total of 37 @entity5 were analyzed for histopathology. The immunoexpression status of MMR genes was correlated with @entity5 stage, location, histology, gender and @entity2280 immunoexpression. RESULTS: Of the 37 cases immunohistochemical analysis showed 13 (35.1%) had loss of expression of @entity6756 , 5 (13.5%) had loss of expression of @entity4311 , and five cases had loss of expression of both proteins. Multivariate analysis showed that right side dominance (p<0.05) poorly differentiated and male (p<0.05) were associated with loss of expression of @entity6756 or @entity4311 . Loss of expression of @entity6756 or @entity4311 correlated with low @entity2280 expression (p>0.05). @entity2280 immunoexpression was higher in the @entity5 location, stage D Dukes'a (p<0.05) and G2 (p<0.05). CONCLUSIONS: These results confirm that sporadic colorectal MMR-defective @entity420 display certain specific morphological characteristics. However, these pathological features are not sufficiently predictive and immunohistochemistry is needed to identify such @entity5 accurately. The researches on angiogenesis of @entity5 cells can be used as prognostic factors for the @entity1 with @entity14 .
