Correlation of angiogenesis with other immunohistochemical markers in cutaneous basal and XXXX .

@entity235 @entity5 @entity957 @entity189 @entity4873 @entity25484 @entity1491 @entity11010
The aim of this study was to establish an immunoprofile of @entity957 ( @entity957 ) and @entity1491 ( @entity1491 ), and to explore as first time in literature the possible correlation between maspin, @entity235 -1, @entity25484 protein and angiogenesis in these @entity5 . For SCCs, the histological grade of differentiation was also taken into account. The angiogenesis was quantified in 38 randomly selected cases of SCCs and 17 BCCc, respectively, using the antibodies @entity11010 ( @entity11010 -A) and @entity4873 , while the microvessel density (MVD) was evaluated with the CD31. RESULTS: In SCCs, maspin cytoplasm to nuclear shift was an indicator of a deeper tissue invasion and dedifferentiation in the invasion front. The poorly differentiated cases, compared to G1  G2-SCCs, expressed more frequent the markers @entity25484 (30.77% vs. 8%) and @entity11010 (53.85% vs. 32%), regardless the MVD. However, the @entity25484 positivity was more frequent in BCCs than SCCs (52.94% vs. 15.79%). All of the @entity25484 -positive @entity189 were located in the head and neck area. @entity235 -1 marked 21.05% of SCCs and 5.88% of BCCs, being directly correlated with @entity4873 positivity. Eccrine glands and hair follicles also expressed @entity235 -1. CONCLUSIONS: In cutaneous SCCs located in the head and neck area, sun-dependent @entity25484  @entity11010 interaction seems to be responsible by @entity5 dedifferentiation, whereas maspin cytoplasm to nuclear shift might indicate a high degree of invasiveness. This is the first report about @entity235 -1 positivity in BCCs and eccrine glands, the significance of this pattern being unknown.
