Prevalence of XXXX in Sudanese @entity1 with @entity146 : a case-control study.

@entity1 @entity2413 @entity527 @entity146 @entity39300 @entity3841
BACKGROUND AND OBJECTIVE: @entity3841 is considered a possible etiological agent for @entity146 . The aim of this study was to determine the prevalence of the @entity39300 clone and non- @entity39300 genotypes of A. actinomycetemcomitans in the @entity527 of @entity1 with @entity146 and controls among Sudanese high-school students. MATERIAL AND METHODS: In a previous study we examined a large representative sample of students attending high schools in Khartoum, Sudan. In this population, 17 @entity1 with @entity146 and 17 controls (14-19 years of age) consented to participate in the present study. The subjects underwent a clinical periodontal examination, and @entity2413 were collected using paper points. The presence of the A. actinomycetemcomitans @entity39300 clone and non- @entity39300 genotypes were assessed using loop-mediated isothermal amplification (LAMP) and the PCR. RESULTS: The @entity39300 clone of A. actinomycetemcomitans was not detected in the @entity527 of either the cases or the controls. Non- @entity39300 types of A. actinomycetemcomitans were detected in the @entity527 of 12 (70.6%) @entity1 with @entity146 and from only one (5.9%) control subject, showing a significantly higher frequency of detection in cases than in controls (p = 0.0001). The odds ratio for the detection of A. actinomycetemcomitans in the @entity527 of the @entity1 with @entity146 was 38.4 (95% confidence interval: 4.0-373.0; p = 0.002). The PCR and LAMP methods showed identical results pertaining to the identification of non- @entity39300 types of A. actinomycetemcomitans. CONCLUSIONS: The @entity39300 clone of A. actinomycetemcomitans was not detected in the @entity527 of high school subjects in Sudan. The detection of non- @entity39300 types of A. actinomycetemcomitans may be a useful marker of increased risk for development of @entity146 in young subjects.
