The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with XXXX .

@entity1641 @entity235 @entity21665 @entity71888 @entity717
BACKGROUND: @entity235 @entity21665 (CECS) is a @entity717 of Border Terriers (BTs). These @entity235 might respond to a gluten-free diet. OBJECTIVES: The objective of this study was to examine the clinical and serological effect of a gluten-free diet in BTs with CECS. ANIMALS: Six client-owned BTs with clinically confirmed CECS. METHODS: @entity235 were prospectively recruited that had at least a 6-month history of CECS based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. @entity235 were tested for anti- @entity71888 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies in the serum at presentation, and 3, 6, and 9  months after the introduction of a gluten-free diet. Duodenal biopsies were performed in 1 dog. RESULTS: Serum TG2 IgA titers were increased in 6/6 BTs (P  =  .006) and AGA IgG titers were increased in 5/6 BTs at presentation compared to those of controls (P  =  .018). After 9  months, there was clinical and serological improvement in all BTs with CECS strictly adhering to a gluten-free diet (5/5). One @entity235 had persistently increased antibody titers. This @entity235 scavenged @entity1641 manure. On the strict introduction of a gluten-free diet this @entity235 also had an improved clinical and serological response. The diet-associated improvement was reversible in 2 @entity235 on completion of the study, both of which suffered a relapse of CECS on the re-introduction of gluten. CONCLUSIONS: @entity235 @entity21665 in BTs is a @entity717 triggered and perpetuated by gluten and thus responsive to a gluten-free diet.
