XXXX , a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin.

@entity1 @entity689 @entity3167 @entity3884 @entity22421 @entity683 @entity281 @entity71168 @entity1729
The @entity683 virus causes @entity1729 , leading to high morbidity and mortality in groups of @entity1 at higher risk. Antiviral drugs represent the first line of defense against @entity683 , both for @entity281 and pandemic outbreaks. Two main classes of drugs against @entity683 are in clinical use: M2-channel blockers and @entity689 inhibitors. Nevertheless, because @entity683 strains that are resistant to these antivirals have been described, the search for novel compounds with different mechanisms of action is necessary. Here, we investigated the anti- @entity683 activity of a fungi-derived natural product, @entity71168 . This compound inhibited @entity683 A and @entity22421 replication. This compound was more effective against @entity683 A(H3N2), with an EC50 of 100 nM. @entity71168 cytoxicity was also very low, with a CC50 value of 1426  M. @entity71168 inhibited @entity683 hemagglutination and, consequently, significantly impaired virus adsorption. Molecular modeling studies revealed that @entity71168 docked in the @entity3167 binding site of hemagglutinin, forming @entity3884 bonds with highly conserved residues. Altogether, our results indicate that the chemical structure of @entity71168 is promising for future anti- @entity683 drug design.
