Effect of AT1 receptor blockade on endothelial function in essential XXXX .

@entity1 @entity917 @entity101 @entity918 @entity2178 @entity1854 @entity7293 @entity842 @entity1129 @entity1063 @entity934
BACKGROUND: @entity2178 adversely affects endothelial function and NO availability. We analyzed the effect of @entity1129 (1) receptor blockade on endothelium-dependent vasodilation and basal @entity842 (NO) production and release in @entity101 @entity1 . METHODS AND RESULTS: Sixty @entity1 (53 +/- 10 years) with essential @entity101 were randomized to 6 weeks of double-blind therapy with either @entity917 (80 mg), @entity918 ( @entity918 ) (25 mg), or placebo once daily. Basal NO production and release was assessed by measuring forearm blood flow (FBF) in response to intra-arterial infusion of @entity7293 ( @entity7293 ), and endothelium-dependent vasodilation by measuring FBF in response to intra-arterial administration of @entity934 , respectively. Intra-arterial infusion of @entity1063 and @entity1854 was used to assess endothelium-independent changes in FBF. Blood pressure (BP) similarly decreased with active treatments (P < .001). After @entity917 treatment, the decrease of FBF in response to @entity7293 was augmented (4 micromol/min @entity7293 , -1.3 +/- 1.2 after v -0.5 +/- 1.1 mL/min/100 mL before therapy, P < .02; 8 micromol/min @entity7293 : -1.7 +/- 1.3 after v -1.1 +/- 1.2 mL/min 100 mL before therapy, P < .05). No improvement was found after placebo or @entity918 treatment. Changes in @entity7293 -induced decrease of FBF with @entity917 treatment were not related to BP changes. Neither drug substantially modified the response of FBF induced by intra-arterial infusion of @entity934 , @entity1063 , and @entity1854 . CONCLUSIONS: The @entity1129 (1) receptor blockade with @entity917 improved basal NO production and release. The effect seems to be BP independent, as BP reduction with @entity918 failed to increase NO availability.
