Whole body vibration therapy: a novel potential treatment for XXXX .

@entity32 @entity2011 @entity6 @entity28 @entity19 @entity4683 @entity3744 @entity636 @entity2006 @entity413
There is a worsening epidemic of @entity28 and @entity6 in the world. Life style interventions including dietary changes and increase in exercise can improve @entity413 metabolism and health in general. However, standard exercise programs are strenuous, time-consuming, and thus have low long-term compliance issues. We tested the feasibility of using high frequency, low amplitude whole body vibration (WBV) therapy to improve @entity413 metabolism in young type 2 @entity6 (T2DM) @entity19 . We also aimed to investigate the postulated anti-inflammatory and cytoprotective properties of WBV. Male db/db and db/m @entity19 were exposed to high frequency, low-amplitude WBV. Outcome parameters comprised of body weight, hemoglobin A1c (HbA1c) level, as well as interleukin (IL)-17 (a marker of helper T cells), @entity3744 ( @entity3744 ; a marker of regulatory T cells), and @entity2006 (an index of DNA injury) expression. Furthermore, a 24  h metabolic cage study was carried out immediately after the WBV protocol and fluid intake, urine excretion and urine osmolality were determined. WBV did not affect body weight but improved HbA1c levels in db/db @entity19 . Vibrated db/db @entity19 demonstrated less fluid intake and urine excretion but better urinary concentrating ability than their non-vibrated controls. Pro-inflammatory changes were significantly reduced, as indicated by reduced @entity636 but increased @entity3744 expression. WBV reduced @entity2006 in db/db @entity19 suggestive of cytoprotective effect. However, WBV was largely without significant effects on assessed parameters in db/m @entity19 . Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, @entity4683 , @entity2011 , and urine osmolality in T2DM in association with reduced @entity32 . Thus, WBV may be a viable adjunctive treatment strategy in T2DM.
