Therapeutic outcome and relation of acute and late side effects in the adjuvant radiotherapy of XXXX stage I and II.

@entity1204 @entity1 @entity137 @entity130 @entity34
BACKGROUND AND PURPOSE: Adjuvant radiotherapy is the standard treatment for @entity1204 . However, until now there has been no clear indication that radiotherapy in that setting improves survival. This calls for critical assessment of the relation between the expected benefit and the number and severity of postradiotherapeutic side effects. MATERIAL AND METHODS: In a retrospective study 159 consecutive @entity1 with stage I and II @entity1204 were treated with external radiotherapy and vaginal brachytherapy after hysterectomy and bilateral salpingoophorectomy (no surgical lymph node staging). Recurrence rates, survival and side effects were evaluated, in particular with regard to the relation of acute and late @entity137 . RESULTS: Five percent of all @entity1 developed a recurrence either in the abdomen or at distant locations. No pelvic relapses were diagnosed. Five-year relapse-free survival was 92% for stage IA + B, 84% for stage IC, and 79% for @entity34 . Acute @entity137 was seen in 65.4% of @entity1 , all grade 1 or 2, late @entity137 grade 1 or 2 in 18.8%, grade 3 or 4 complications in 1.8%. The estimated 5-year freedom from late @entity137 was 76.8%. Seventy-seven percent of all @entity1 with treatment interruptions or premature end of therapy experienced @entity130 . In ten of 33 @entity1 with late sequelae there was no free interval between early and late @entity137 . No relation of radiation technique/fractionation and the rate of side effects was noticed. CONCLUSIONS: Adjuvant radiotherapy leads to excellent pelvic control, with few serious complications. Major acute @entity137 shows significant correlation with the incidence of severe @entity130 , which we suggest to classify in part as consequential late effects.
