[Analysis of the relationship of DNA mismatch repair with clinicopathologic features and prognosis of XXXX ].

@entity1 @entity6756 @entity3079 @entity5 @entity4311 @entity14437 @entity3 @entity694 @entity420 @entity4638
OBJECTIVE: To explore the relationship between DNA mismatch repair (MMR) and clinicopathologic features and prognosis in @entity1 with @entity5 . METHODS: The clinical and pathological data of 440 @entity1 with @entity5 after radical resection were retrospectively reviewed and analyzed. Immunohistochemical staining was used to assess the expression of MMR proteins ( @entity6756 , @entity4311 , @entity4638 and @entity14437 ), and the correlation between DNA MMR and clinicopathological features and prognosis of @entity694 was analyzed. RESULTS: Of the 440 @entity5 samples tested for DNA mismatch repair status, 90 (20.5%) demonstrated defective DNA mismatch repair and 350 (79.5%) had proficient DNA mismatch repair. Defective DNA mismatch repair (dMMR) was associated with young @entity1 ( <=60), proximal @entity5 , poorly differentiated @entity420 and @entity3079 (P<0.05 for all). Among the 440 @entity1 , 126 (28.6%) cases had recurrence or @entity3 and 93 (21.1%) died during the median follow-up of 61.0 months. The five-year disease-free survival (DFS) rate was 82.2% among the @entity1 with @entity5 exhibiting dMMR, significantly higher than that in @entity1 with @entity5 exhibiting pMMR (68.9%, P=0.02). The univariate and mutlivariate analyses showed that the MMR status is an independent factor affecting 5-year disease-free survival and overall survival (OS) in @entity694 @entity1 (P<0.05 for both). CONCLUSIONS: Defective DNA mismatch repair (dMMR) is associated with @entity1 with proximal @entity5 and poorly defferentiated @entity420 and @entity3079 . The prognosis for @entity1 with dMMR is better than those with pMMR. dMMR may be a useful biomarker for the prognosis of @entity694 .
