Inhaled @entity842 reduces lung XXXX during fluid resuscitation in ovine @entity647 .

@entity1 @entity1680 @entity3952 @entity742 @entity3126 @entity4 @entity26 @entity651 @entity3652 @entity842 @entity880 @entity3485 @entity1363 @entity16486 @entity647
OBJECTIVE: Fluid resuscitation in sepsis-related @entity651 is limited by aggravation of @entity3126 . @entity3485 , however, may compromise tissue perfusion and contribute to organ dysfunction. We hypothesized that inhaled @entity842 would reduce @entity4 formation during fluid therapy. DESIGN AND SETTING: Prospective laboratory investigation in a university research laboratory. @entity1 : Eighteen chronically instrumented @entity742 . INTERVENTIONS: The animals were randomly assigned to one of three groups and received endotoxin ( @entity1680 , 10 ng kg(-1) min(-1)) for 30 h. After 24 h the @entity742 were anesthetized ( @entity3652 / @entity1363 ), mechanically ventilated with @entity26 , and received 0.1 ml kg(-1) @entity3952 : @entity16486 group (n=6), an infusion of Ringer's lactate was restricted to 1 ml kg(-1) h(-1); fluid/oxy group (n=6), a bolus of 10 ml kg(-1) Ringer's @entity880 plus 10 ml kg(-1) h(-1) was given; fluid/NO group (n=6), the @entity742 were treated as in the fluid/oxy group, except that they inhaled @entity842 (20 ppm). MEASUREMENTS AND RESULTS: The extravascular lung water index was measured using thermodye dilution. @entity3952 increased extravascular lung water, impaired oxygenation, and reduced cardiac index at 26 h in all groups. After 30 h the extravascular lung water in the fluid/NO group was not higher than in the oxy group and significantly than in the fluid/oxy group. While cardiac index returned to the level of sepsis baseline in fluid/NO and fluid/oxy, it was reduced in the oxy group after 30 h. There were no significant differences in cardiac index between groups. CONCLUSIONS: Inhaled @entity842 may be an option for reducing @entity4 formation secondary to fluid resuscitation in @entity647 .
