Influence of karyotype on outcome of allogeneic bone marrow transplantation for adults with precursor B-lineage XXXX in first or second remission.

@entity1 @entity981 @entity8461 @entity66 @entity2132
The prognostic relevance of karyotype has been established in adult @entity981 ( @entity981 ) @entity1 treated with chemotherapy but not definitively evaluated in an allogeneic bone marrow transplantation (BMT) setting. To determine the factors affecting the outcome of allogeneic BMT for adults with precursor B-lineage @entity981 in first or second complete remission (CR), a total of 41 consecutive @entity1 with a successful karyotype were enrolled in this study. There were 21 @entity1 and 20 @entity1 with a median age of 27 (15-43) years. The distribution of @entity8461 ( @entity8461 ) subtypes was as follows: L1 (n = 26), L2 (n = 15). Unfavourable karyotypes (n = 12) were defined as Ph+ or t(4;11). Disease status at the time of transplant was first CR (n = 35) or second CR (n = 6). With a median follow-up of 36 months, the 3-year probabilities of relapse and @entity66 ( @entity66 ) were 36.3 +/- 8.4% and 57.3 +/- 8.4% respectively. Potential variables predicting worse relapse and @entity66 were @entity8461 subtype (L2), extramedullary involvement, pre-BMT status (second CR), unfavourable karyotype and type of @entity2132 ( @entity2132 ). Further multivariate analysis showed that karyotype and pre-BMT status were independently associated with relapse and @entity66 . In addition, chronic @entity2132 was found to be significantly associated with a lower relapse rate.
