@entity1 striatum: chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and XXXX .

@entity1 @entity43147 @entity1110 @entity1877 @entity842 @entity460 @entity195 @entity35 @entity1943
The morphology and distribution of perikarya positive for @entity1877 acetyltransferase, @entity1943 , @entity460 binding protein (calbindin @entity43147 ) and @entity1110 diaphorase were surveyed in the @entity1 striatum. @entity1877 acetyltransferase and @entity1943 antibodies labeled separate populations of large striatal interneurons. @entity1943 immunoreactivity and @entity1110 diaphorase ( @entity842 synthase) activity were completely co-localized. Calbindin antibody identified two distinct groups of striatal neurons: (1) numerous medium-sized, lightly stained neurons, probably analogous to striatopallidal projection neurons in the @entity35 , and (2) much less numerous, large, darkly stained neurons. Half of the latter group, but none of the former, were also @entity1110 diaphorase-positive. @entity1943 -positive and medium-sized, calbindin-positive neurons were more numerous in the caudate nucleus than in the putamen or ventral striatum. By contrast, large calbindin-immunoreactive neurons were more frequently encountered in the putamen. @entity1877 acetyltransferase-positive neurons were evenly distributed across striatal components. In aged control subjects, the size of large, darkly stained calbindin-positive neurons was reduced relative to young subjects. Aging had no effect on @entity1943 -, medium-sized calbindin-, or @entity1877 acetyltransferase-positive neurons. However, in histologically confirmed cases of @entity195 , there was a selective, 75% loss of @entity1877 acetyltransferase-immunoreactive perikarya from the ventral striatum, but not from the dorsal striatum, compared to aged controls. Furthermore, the remaining cholinergic neurons in the ventral striatum of @entity195 cases were significantly smaller than similar neurons in controls. These results indicate that various striatal components which have been shown to differ in their anatomical connectivity and functional specialization, also differ in their neurochemical signatures. The specific and marked loss of @entity1877 acetyltransferase-positive neurons from the ventral striatum in @entity195 is consistent with the characteristic cholinergic and 'limbic' pathology in this disease.
