Microwave attenuation of @entity1068 -induced XXXX : @entity1068 tolerance, time course, exposure duration, and dose response studies.

@entity167 @entity1219 @entity35 @entity1068 @entity2332
Four experiments were conducted to quantify the reported attenuation by microwave (MW) irradiation of @entity1068 -induced @entity2332 . In one experiment @entity35 were irradiated (continuous wave 2.45 GHz, specific absorption rate = 0.3 W/kg) or sham irradiated for 45 min, injected with 3.6 g/kg, 20% (v/v) @entity1068 ( @entity167 ) or saline ( @entity1219 ) i.p.. Colonic temperature was monitored at 20-min intervals for 2 h. This procedure was repeated for 8 days to determine the rate of tolerance development to the hypothermic effect of @entity1068 . While MW irradiation did significantly attenuate @entity167 -induced @entity2332 , it did not enhance or retard the rate of tolerance development. To determine the duration of irradiation necessary to attenuate @entity167 -induced @entity2332 , groups of @entity35 were irradiated or sham irradiated for 5, 15, 30, or 60 min prior to @entity167 injection and subsequent temperature measurements. The attenuation was apparent only after 60 min of irradiation. To determine the duration of the attenuation effect after irradiation, @entity35 were injected with @entity167 or @entity1219 at 0, 30, 60, 120, or 480 min after 45 min of irradiation or sham irradiation. The attenuation effect was apparent among @entity35 injected 0 to 30 min after irradiation and for the first 40 min for groups injected at 120 min. Additional @entity35 were injected with @entity1219 or 0.9, 1.8, or 2.7 g/kg of @entity167 i.p. following 45 min of irradiation or sham irradiation to determine if the attenuation effect depends on the dose of @entity167 administered. Attenuation of @entity167 -induced @entity2332 was more apparent at lower doses of @entity167 than at higher doses. These results indicate that the effect is an acute response to irradiation, and rule out several other potential explanations.
