Polymorphic Variants in Oxidative Stress Genes and Acute @entity137 in @entity0 XXXX Receiving Radiotherapy.

@entity1 @entity137 @entity0 @entity9554 @entity1161 @entity4723 @entity26 @entity21005 @entity4191 @entity56961
Purpose: Reactive @entity26 species (ROS) are generated as an indirect product of @entity1161 ( @entity1161 ). Genetic variation in genes related to ROS metabolism may influence the level of @entity1161 -induced adverse effects. We evaluated the potential association of single nucleotide polymorphism (SNP)-related response to radiotherapy injury in @entity0 @entity1 undergoing @entity1161 . Materials and Methods: Eighty @entity1 receiving conventional @entity1161 were included. Acute effects were evaluated according to the Radiation Therapy Oncology Group (RTOG) scores. DNA was extracted from blood and buccal swab samples. SNPs were genotyped for @entity4191 , @entity56961 , @entity4723 , and @entity9554 genes by polymerase chain reaction-based restriction-fragment-length-polymorphism (PCR-RFLP). Univariate analysis (ORs and 95% CI) and principal component analysis were used for correlation of SNPs and factors related to risk of developing >=  grade 2 acute effects. Results: Sixty-five @entity1 (81.2%) showed side effects, 32 (40%) presented moderate to severe acute @entity137 , and 33 (41.2%) manifested minimal acute skin reactions by the end of treatment. In both univariate and multivariate analyses, nominally signi   cant associations were found among body mass index (OR, 3.14; 95% CI, 8.5338- 1.1274; p= 0.022), breast size (OR, 5.11; 95% CI, 17.04- 1.54; p= 0.004), and grade >= 2 acute radiation @entity137 . A significant association was also observed between @entity9554 @entity21005 polymorphism (OR, 9.8, 95% CI, 211.6- 0.45; p= 0.041) and grade >= 2 acute radiation @entity137 in @entity1 with neo-adjuvant chemotherapy treatment. Conclusion: The analysis of the factors involved in individual radiosensitivity contributed to the understanding of the mechanisms underlying this trait.
