Comprehensive Outcome Researches of Intralesional XXXX Injection on Benign Vocal Fold Lesions.

@entity1 @entity4122 @entity2713 @entity132 @entity1127 @entity7364 @entity1410 @entity194 @entity8823 @entity479
OBJECTIVE: This study investigated multidimensional treatment outcomes, including prognostic factors and side effects of vocal fold @entity479 injection (VFSI). METHODS: We recruited 126 consecutive @entity1 , including @entity1 with 49 nodules, 47 @entity1127 , and 30 mucus retention cysts. All the @entity1 received VFSI under local anesthesia in the office settings. Treatment outcomes were evaluated 1 and 2 months after the procedure, including endoscopic evaluation, @entity132 (GRB scores), acoustic analysis, and 10-item Voice Handicap Index (VHI-10). RESULTS: More than 80% of the @entity1 reported subjective improvements after VFSI. Objective measurements revealed significant improvements from baseline in most of the outcome parameters (P<0.05). Higher occupational vocal demands and fibrotic vocal nodules were significantly associated with poorer clinical responses as measured by the VHI-10 and GRB scores, respectively. For vocal @entity1127 , @entity7364 for more than 12 months were significantly associated with higher postoperative VHI-10 scores, whereas @entity1 with @entity8823 ( @entity8823 ) showed significantly poor postoperative voice quality as measured by GRB scores. Side effects after VFSI included @entity1410 (27%), @entity2713 deposits (4%), and vocal @entity194 (1%), which resolved spontaneously within 1-2 months. Presentation with vocal fold @entity4122 /varicosities and higher vocal demands were significantly correlated with postoperative vocal @entity1410 . CONCLUSIONS: This study demonstrated significant improvements after VFSI in vocal nodules, @entity1127 , and cysts. Occupational vocal demand and subtypes of vocal nodules are closely related to the treatment outcomes after VFSI, whereas symptom duration and @entity8823 were significant prognostic factors for VFSI treatment outcomes in vocal @entity1127 . Side effects after receiving VFSI were mostly self-limited without sequel, whereas the incidence rates might be varied by the injection approach and the timing for postoperative follow-up.
