Patterns of fetal and childhood growth and the development of XXXX in young males: a cohort study.

@entity1 @entity161 @entity716 @entity6
Factors influencing fetal and childhood growth may affect a @entity1 's risk of developing @entity161 . Associations of size at birth and body size in young adulthood with @entity161 and other nonaffective psychoses were assessed in a cohort of 334,577 Swedish male conscripts born in 1973-1980 for whom linked birth, census, hospital admission, and adult height and weight data were available. Complete data on all study variables were available for 246,655 subjects. Over a mean 3.4-year follow-up beginning at age 18 years, 80 subjects developed @entity161 and 124 developed other nonaffective psychoses. A reverse J-shaped association was found between gestation-adjusted birth weight and @entity161 . The hazard ratios were 7.03 (95% confidence interval: 1.59, 31.10) for males of low birth weight (<2.5 kg) and 3.37 (95% confidence interval: 1.68, 6.74) for those of high birth weight (>4.0 kg). Birth weight was not strongly related to other nonaffective psychoses. Taller males had a reduced risk of @entity716 . The lowest risks were seen for low birth weight males who became tall adults. The associations with birth weight indicate that fetal exposures, including possible effects of gestational @entity6 , are important in the etiology of @entity716 . The role of childhood exposures, as indexed by adult height and body mass index, appears to be less strong.
