Haemostatic function and biomarkers of endothelial damage before and after platelet transfusion in XXXX with @entity3052 .

@entity1 @entity1423 @entity13221 @entity3052
OBJECTIVES: The beneficial effect of platelet transfusion on haemostasis is well established, but there is emerging evidence that platelet transfusion induces an inflammatory response in vascular endothelial cells. BACKGROUND: We investigated haemostatic function and endothelial biomarkers before and after platelet transfusion in @entity1 with @entity3052 . MATERIALS AND METHODS: Blood was sampled before, 1 and 24   h after platelet transfusion. Primary and secondary haemostasis was evaluated by whole blood aggregometry (Multiplate) and thromboelastography (TEG). Endothelial biomarkers (sICAM-1, @entity13221 , sThrombomodulin, sVE-Cadherin) and platelet activation biomarkers (sCD40L, TGF-beta) were investigated along with haematology/biochemistry analyses. RESULTS: Twenty-two @entity1 were included. Despite continued low platelet counts, platelet transfusion normalised the median values of most TEG parameters and slightly increased @entity1423 (all P   <   0  05). Endothelial biomarkers were not significantly affected by transfusion. The 1   h sCD40L level correlated positively with @entity13221 and soluble thrombomodulin delta values, biomarkers of endothelial damage (both P   =   0  005). CONCLUSION: Platelet transfusion improved haemostasis, whereas post-transfusion increases in sCD40L were associated with endothelial damage, indicating that transfused platelets and platelet-derived pro-inflammatory mediators may have opposite effects on the endothelium.
