Determinants for Achieving the XXXX Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan.

@entity1 @entity66 @entity3918 @entity2299 @entity6 @entity412 @entity11429 @entity453 @entity1011 @entity731 @entity65 @entity165
BACKGROUND: Epidemiological and clinical studies have clearly established the link between low-density lipoprotein @entity165 ( @entity11429 ) and @entity731 -related cardiovascular consequences. Although it has been a common practice for physicians to prescribe lipid-lowering therapy for @entity1 with @entity2299 , the achievement rate is still not satisfied in Taiwan. Therefore, the determinants for achieving the @entity11429 target needed to be clarified for better healthcare of the @entity1 with @entity2299 . METHOD: This registry-type prospective observational study enrolled the @entity1 with @entity65 ( @entity453 ( @entity453 ) and @entity66 ( @entity66 )) from 18 medical centers across Taiwan, and clinically followed them for five years. At every clinical visit, vital signs, clinical endpoints, adverse events, concurrent medications and laboratory specimens were obtained as thoroughly as possible. The lipid profile (total @entity165 , high-density lipoprotein @entity165 , @entity11429 , @entity412 ), liver enzymes, and @entity1011 phosphokinase were evaluated at baseline, and every year thereafter. The cross sectional observational data was analyzed for this report. RESULT: Among the 3,486 registered @entity1 , 54% had their @entity11429 < 100 mg/dL. By univariate analysis, the @entity1 achieving the @entity11429 target were associated with older age, more male sex, taller height, lower blood pressure, more under lipid-lowering therapy, more smoking cessation, more history of @entity453 , @entity3918 , physical activity, but less history of @entity66 . The multivariate analysis showed statin therapy was the most significant independent determinant for achieving the treatment target, followed by age, history of @entity453 , @entity6 , blood pressure, and sex. However, most @entity1 were on regimens of very-low to low equipotent doses of statins. CONCLUSION: Although the lipid treatment guideline adherence is improving in recent years, only 54% of the @entity1 with @entity65 have achieved their @entity11429 target in Taiwan, and the most significant determinant for this was statin therapy.
