Prognostic Value of Vascular Invasion in Well-Differentiated XXXX .

@entity3557 @entity1 @entity5 @entity3 @entity259 @entity1349
BACKGROUND: Vascular invasion (VI) is an important predictor of distant @entity3 and possible radioactive iodine (RAI) benefit in follicular, H  rthle cell, and poorly differentiated @entity259 , but its role in well-differentiated @entity3557 (WDTC) remains unclear. METHODS: Archived pathological material of all differentiated @entity259 @entity1 undergoing primary surgical treatment at Memorial Sloan-Kettering Cancer Center between 1986 and 2003 was reviewed by two dedicated thyroid pathologists. Only WDTCs were included in the present study. Standard statistical methods were used to assess the relationship between VI and outcomes of interest, including 10-year disease-specific survival (DSS), @entity1349 ( @entity1349 ), and distant recurrence-free survival (DRFS). RESULTS: VI was present in 47 of 698 WDTC (6.7%). VI was significantly associated with @entity5 size >4.0   cm, extrathyroidal extension, distant @entity3 , and RAI treatment. On univariate analysis, VI was predictive of decreased 10-year DRFS, but not DSS or @entity1349 . On multivariate analysis, VI was not an independent predictor of DRFS. Univariate survival analysis of 422 RAI-na  ve WDTC showed that both size >4   cm and VI were predictors of outcome, but only size remained independently predictive on multivariate analysis. CONCLUSION: The presence of VI is not an independent predictor of outcome in WDTC.
