Early manifestation of XXXX in @entity35 with arterial @entity730 .

@entity8 @entity3875 @entity15822 @entity1372 @entity177 @entity730 @entity460 @entity972 @entity35 @entity10040
In vascular smooth muscle, @entity460 overload is a highly pathogenic event, which increases with advancing age. An increase in the @entity460 content of arterial wall may be produced in @entity35 by treatment with @entity3875 . The aim of this study was to evaluate the renal clearance of @entity10040 (a model organic anion, preferentially eliminated by the kidneys) and other @entity177 in @entity35 with arterial @entity730 . Arterial @entity730 was produced in adult @entity35 by means of a single dose of @entity3875 (300,000 UI/kg bw, i.m.) 5 days before the experiment. Treated @entity35 showed a large increase in @entity460 content of aortic tissue and an increase in systolic arterial pressure. No modifications were observed in plasma @entity460 levels and in plasma lipid profiles. Statistically significant decrements were observed in renal clearance of @entity10040 , in renal blood flow, in fractional excretion of @entity1372 and @entity972 . A slight decrease, not statistically different, was observed in the glomerular filtration rate. @entity35 with arterial @entity730 also showed an increment of total @entity460 levels in renal tissue, in fractional excretion of @entity460 and in the expression of @entity15822 ( @entity15822 ). Histological studies revealed tubular alterations. In summary, modifications in hemodynamics and tubular parameters are early manifestations of @entity8 in @entity35 with arterial @entity730 , some of which may account for the changes observed in organic anions renal depuration. It is important to mention that the decrease in clearance of organic anions were seen in spite of the increase in expression of @entity15822 .
