Can We Stop Antibiotic Therapy When Signs and Symptoms Have Resolved in XXXX @entity1 ?

@entity1 @entity3657 @entity6 @entity281 @entity204
The study aimed to investigate whether we can stop antibiotic therapy when signs and symptoms have resolved in @entity6 ( @entity6 ) @entity1 with different grades of @entity3657 ( @entity3657 ) and those without @entity3657 , and to determine whether the severity of @entity3657 and @entity281 has an effect on antibiotic therapy duration. A prospective randomized controlled trial of @entity6 @entity1 was carried out. @entity1 were randomized into 2 groups when signs and symptoms had resolved: continuing antibiotics group (CAG) and discontinuing antibiotics group (DAG). The recurrence and clinical outcomes were recorded. The recurrence rate of mild @entity281 with mild/moderate @entity3657 was similar in the 2 groups. Compared with CAG, the recurrence rate of mild @entity281 with severe @entity3657 was higher in DAG (P = .030), also for moderate/severe @entity281 with @entity3657 (mild/moderate [P = .032]; severe [P = .008]). No difference was found in the 2 groups (either mild or moderate/severe) for those without @entity3657 . The clinical outcomes of mild @entity281 in @entity1 were similar in the 2 groups. For moderate/severe @entity281 , the healing rate was higher (73.3% vs 48.3%), and the rate of minor/major amputation and @entity204 was lower (23.8% vs 49.4%; 6.9% vs 20.7%; 2.0% vs 13.8%) in the CAG. When the clinical signs and symptoms of @entity281 have resolved, it might be appropriate to stop antibiotics for @entity6 @entity1 without @entity3657 , and also for @entity1 with mild @entity281 with mild/moderate @entity3657 . For @entity1 with mild @entity281 with severe @entity3657 and moderate/severe @entity281 with @entity3657 , we should perhaps continue antibiotic treatment. Continuing antibiotic therapy could improve clinical outcomes for @entity1 with moderate/severe @entity281 .
