Influence of biomechanical parameters on cranial cruciate ligament-deficient or -intact XXXX stifle joints assessed by use of a computer simulation model.

@entity235 @entity10089 @entity2720 @entity717 @entity942
OBJECTIVE To investigate the influence of 4 biomechanical parameters on @entity235 cranial cruciate ligament (CrCL)-intact and - @entity2720 . SAMPLE Data for computer simulations of a healthy 5-year-old 33-kg neutered male Golden Retriever in a previously developed 3-D rigid body pelvic limb computer model simulating the stance phase during walking. PROCEDURES @entity235 stifle joint biomechanics were assessed when biomechanical parameters (CrCL stiffness, CrCL prestrain, body weight, and stifle joint friction coefficient) were altered in the pelvic limb computer simulation model. Parameters were incrementally altered from baseline values to determine the influence on stifle joint outcome measures (ligament loads, relative tibial translation, and relative @entity717 ). Stifle joint outcome measures were compared between CrCL-intact and - @entity2720 for the range of parameters evaluated. RESULTS In the CrCL-intact stifle joint, ligament loads were most sensitive to CrCL prestrain. In the @entity942 stifle joint, ligament loads were most sensitive to body weight. Relative tibial translation was most sensitive to body weight, whereas relative @entity717 was most sensitive to CrCL prestrain. CONCLUSIONS AND CLINICAL RELEVANCE In this study, computer model sensitivity analyses predicted that CrCL prestrain and body weight influenced stifle joint biomechanics. @entity10089 may influence the likelihood of @entity942 . Body weight could play an important role in management of @entity235 with a @entity942 stifle joint.
