Associations between muscle perfusion and symptoms in XXXX : a cross sectional study.

@entity1 @entity626 @entity571 @entity3331 @entity158 @entity9243
OBJECTIVE: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging ( @entity9243 -MRI) and symptoms in @entity1 with @entity626 ( @entity626 ). DESIGN: In a cross-sectional setting, muscle perfusion was quantified by @entity9243 -MRI in @entity626 . Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single "Total Muscle Volume" volume of interest (VOI). Symptoms were assessed via the @entity3331 and @entity571 Outcome Score (KOOS) (0: worst; 100: best). RESULTS: @entity9243 -MRI and clinical data were analyzed in 94 @entity1 . The typical @entity1 was a @entity1 with a mean age of 65 years, and a body mass index (BMI) of 32  kg/m(2). Reduced multiple regression models analyzing the association between KOOS and @entity9243 -MRI perfusion variables of Total Muscle Volume showed a statistically significant association between Nvoxel% and KOOS @entity158 (0.41 (SE 0.14); P  =  0.0048). Nvoxel% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. CONCLUSIONS: More widespread perfusion in the peri-articular knee muscles was associated with @entity158 in @entity1 with @entity626 . These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and @entity158 improvements in the conservative management of @entity626 .
