@entity3303 metabolite formation: an indicator for XXXX and predictor of survival in surgical intensive care @entity1 .

@entity1 @entity3124 @entity409 @entity17542 @entity3303
Formation of the @entity3303 metabolite @entity17542 ( @entity17542 ) by hepatic cytochrome P450 enzymes is a new method for evaluating liver function. The purpose of this study was to compare @entity17542 formation with other liver function parameters in surgical intensive care unit @entity1 . The study include 29 @entity3124 @entity1 who had been admitted to the unit for more than 3 days with a median APACHE III score-predicted mortality > 30%. On day 4, @entity3303 was given intravenously at a dose of 1 mg.kg-1 over 2 min and @entity17542 formation was measured 15 min later. Eighty-nine percent of the @entity1 had @entity17542 values below 90 micrograms.l-1 indicating @entity409 . Eleven @entity1 died, 18 @entity1 survived. The group of @entity1 with fatal outcome had significantly lower @entity17542 values (median: 23 micrograms.l-1) than the group of survivors (median: 53 micrograms.l-1, p < 0.01). Bilirubin values were elevated in the non-survivor group (median: 2.8 mg.dl-1) compared to the survivors (median: 0.9 mg.dl-1, p < 0.05). There was no significant difference between two groups in the other liver function tests. We conclude from our results that the @entity17542 test can be considered an indicator for @entity409 and predictor of survival in @entity3124 @entity1 .
