Overdiagnosis of XXXX .

@entity1 @entity32 @entity263 @entity1069 @entity66 @entity5 @entity1373 @entity3923 @entity194 @entity4623 @entity5436 @entity1412 @entity1491
A wide variety of histopathologic mimics of @entity263 have been recently described, which may cause overdiagnosis of @entity5 . To our knowledge, the frequency and causes of overdiagnosis of @entity263 have not been previously examined. Two pathologists evaluated the Mayo Clinic experience with small foci of stage T1a @entity5 diagnosed between 1960 and 1970 in an effort to identify cases that were overdiagnosed as @entity5 . Only cases with available diagnostic slides and blocks were re-evaluated, and immunohistochemical studies were obtained in select cases to confirm the amended diagnoses. Follow-up was obtained in all cases from @entity1 medical records. We identified a total of 31 @entity1 who were overdiagnosed with @entity263 from among a series of 150 cases initially diagnosed as well-differentiated stage T1a @entity5 (21% incidence). @entity1 ranged in age from 42 to 85 years, and the weight of the transurethral resections varied from 6 to 90 g. Findings misinterpreted as @entity5 included @entity1412 (8 cases), @entity1491 (8), @entity194 (5), sclerosing @entity3923 (3), high-grade @entity5436 (3), xanthogranulomatous @entity1069 (2), florid cribriform @entity1373 (1), and post- @entity1373 (1). None of the @entity1 received additional treatment for @entity4623 . Mean follow-up was 10.8 years; 14 @entity1 were alive with no evidence of disease, 14 died of @entity66 without recurrent @entity4623 , and the status of 3 was unknown. We conclude that misinterpretation of @entity263 in transurethral resection specimens results from overdiagnosis of small microscopic foci of @entity1373 , @entity194 , @entity5436 , and @entity32 . The incidence of overdiagnosis three decades ago was 21% of small foci in transurethral resections, usually resulting from the presence of undescribed pathological entities. Long-term follow-up revealed no evidence of recurrent @entity4623 .
