Effect of @entity2400 in experimental XXXX : evaluation with ultrastructural findings and early clinical results.

@entity1024 @entity35 @entity2400 @entity1566 @entity130 @entity1760
Excitotoxic mechanisms have been implicated in the pathophysiology of @entity1566 ( @entity1566 ). The authors have studied the protection against secondary damage to @entity35 spinal cord with @entity2400 , a well-known @entity1024 antagonist. @entity35 were randomly allocated into 5 groups. Group 1 @entity35 were controls and normal spinal cord samples were obtained after clinical examination. 50 g-cm contusion injury was introduced to Group 2. Group 3 was vehicle, 1 cc of physiologic saline was injected post- @entity130 . Group 4 and 5 were treatment groups and 100 mg/kg and 600 mg/kg of @entity2400 was given immediately after @entity130 , intraperitoneally. Animals were evaluated with inclined plane, Tarlov motor scale and Basso-Beattie-Bresnahan scale 24h after @entity1566 . Spinal cord samples for ultrastructural evaluations were obtained following clinical examinations. @entity1760 treatment improved neurological outcome. Electron microscopic results showed obvious neuroprotection in the treatment groups. Application of 600 mg/kg of @entity1760 revealed better ultrastructural findings and clinical results than 100 mg/kg. These findings demonstrated that @entity2400 possesses neuroprotection on spinal cord ultrastructure and on functional scores after acute contusion injury to the @entity35 spinal cord.
