[ @entity1613 and XXXX of the endometrium].

@entity1204 @entity1 @entity632 @entity101 @entity6 @entity66 @entity28 @entity5 @entity548 @entity7828 @entity1613 @entity1412 @entity420
In recent years the incidence in @entity1204 is rising. The relation of cervical to @entity1204 has shifted to almost 1:1. The peak of age distribution is between 50 and 60 years of age. @entity66 are @entity28 , @entity6 and @entity101 . The @entity1204 has its precancerous stages. The pertinent estrogenic stimulus is probably significant for the development of @entity1613 : @entity1412 without atypias is known as an optional, that with atypia as an obligatory precancerous lesion. The range of morphologic variation extends from mature @entity1204 with favorable prognosis to @entity5 with unfavorable outcome. Besides various other parameters of @entity5 the depths of infiltration into the myometrium is known to be significant. The leading sign of @entity1204 is uterine @entity548 . The histological diagnosis is established by the examination of the tissue produced by curettage from the cervical canal and from the uterine cavity. A true early diagnosis--in comparison to the early detection of cervical @entity5 --does still not exist for @entity1204 . Exfoliative cytology from the uterine cavity or ultrasonography does still not allow the final and definite diagnosis. Among the therapeutic alternatives abdominal hysterectomy in combination with bilateral adnexectomy plays the most important role. Depending from more specific morphologic criteria of a given case additional pelvic and paraaortic lymphnode-dissection is advised. Surgical therapy in general accounts for a 10 to 20 percent better survival. In @entity1 who cannot surgically be treated because of the local extension of the @entity5 or due to a general high risk situation the primary therapy is pelvic irradiation both by packing and percutaneously. Disseminated @entity5 , @entity420 in particular, respond well to large dosages of @entity7828 , whereas combinations of cytostatics have failed to show favorable results, perhaps with the exception of those containing @entity632 . All @entity1204 @entity1 need special posttreatment care, because early recurrences still have a certain chance of survival when recognized and appropriately treated.
