Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic XXXX .

@entity32 @entity6722 @entity19 @entity1200 @entity35 @entity130
UNASSIGNED: Our previous RNA-sequencing analysis of the @entity35 cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response of the cochlea to @entity130 . Here, we compared the RNA-sequencing data collected from @entity19 and @entity35 that sustained a similar, but not identical, @entity130 . The transcriptome analysis of cochlear genes identified the differentially expressed genes in the @entity19 and @entity35 samples. Bioinformatics analysis revealed a marked similarity in the changes in the biological processes between the two species, although the differentially expressed genes did not overlap well. The common processes associated with the differentially expressed genes are primarily associated with @entity1200 and @entity32 , which include the immune response, response to wounding, the defense response, @entity6722 and inflammatory responses. Moreover, analysis of the molecular pathways showed considerable overlap between the two species. The common pathways include cytokine-cytokine receptor interactions, the chemokine signaling pathway, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway. Further analysis of the transcriptional regulators revealed common upstream regulators of the differentially expressed genes, and these upstream regulators are also functionally related to the immune and inflammatory responses. These results suggest that the immune and inflammatory responses are the essential responses to acoustic overstimulation in the cochlea.
