Magnesium sulfate prevents @entity1937 -induced XXXX in @entity1 undergoing thyroidectomy.

@entity1 @entity1931 @entity1937 @entity2400 @entity158 @entity282 @entity1760
BACKGROUND: In a randomized, double-blind, prospective study, we investigated whether an intraoperative high versus low dose of @entity1937 increased @entity1931 and whether @entity1760 can prevent @entity1937 -induced @entity1931 . METHODS: Ninety @entity1 undergoing thyroidectomy were randomly assigned to 1 of 3 groups. @entity1937 was intraoperatively infused at 0.05  g/kg/min (group LO) or 0.2  g/kg/min (groups HI and HM). @entity1 in group HM received @entity2400 30 mg/kg at induction followed by an intraoperative infusion of 10 mg/kg/h. @entity158 thresholds on the forearm and periincisional area were assessed by von Frey filament the evening before surgery and postoperatively at 24 and 48 hours. @entity158 measured on a verbal numerical rating scale (VNRS) (0-10) and additional analgesics were recorded in the postanesthesia care unit postoperatively at 6, 24, and 48 hours. RESULTS: There was a significantly greater decrease in @entity158 threshold on the periincisional area at 24 and 48 hours postoperatively in group HI, as compared with the other 2 groups. The 95% confidence intervals for the mean difference in @entity158 thresholds on the periincisional area at 24 and 48 hours postoperatively were 0.31 to 1.11 and 0.36 to 1.14 for group HI versus group LO, 0.45 to 1.26 and 0.54 to 1.32 for group HI versus group HM (values are log(10) of force in milligrams). The change in @entity158 threshold on the forearm was similar among the groups. Group HI had significantly higher VNRS scores (median [interquartile range], 3 [2-4]) than group LO (2 [1-3] and group HM (2 [1-3]) at 48 hours postoperatively. The 95% confidence intervals for median difference in VNRS score at 48 hours postoperatively were 1 to 2 for group HI versus group LO and 0 to 2 for group HI versus group HM. There were no significant differences in the number of @entity1 who requested rescue analgesics in the postoperative anesthesia care unit and general ward during 48 hours postoperatively among the 3 groups. CONCLUSIONS: A relatively high dose of intraoperative @entity1937 enhances periincisional @entity1931 . Intraoperative @entity2400 prevents @entity1937 -induced @entity1931 . However, @entity1931 did not reach clinical relevance in terms of @entity282 or analgesic consumption in @entity1 undergoing thyroidectomy.
