Concurrent interferon-alpha and radiation for XXXX .

@entity1 @entity135 @entity137 @entity5 @entity3027 @entity320
@entity320 cells are resistant to radiation in part due to their capacity to repair sublethal damage. A large fraction dose is therefore often utilized. However, if the @entity5 is located close to critical structures with modest tolerance, high fraction doses increase the risk for late complications compared with standard fractionation, but using the latter alone risks the desired outcome. Concurrent systemic biotherapy with standard radiation fractions may therefore represent an acceptable compromise. The outcome of concurrent systemic interferon-alpha ( @entity3027 ) and radiation in three @entity1 with @entity135 was evaluated. Standard radiation fractions were used because of the radiosensitizing properties of @entity3027 . Acute @entity137 was significant and required treatment interruptions. However, all side effects subsided following treatment. All three @entity1 achieved local control at follow-up periods of 24, 18 and 19 months, respectively. One @entity1 developed widespread distant metastases. The combination of @entity3027 with radiation is considered feasible in terms of outcome and should be investigated with a larger cohort of @entity1 . @entity137 is significant, and the addition of radioprotectors could be desirable.
