Primary XXXX . A histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations.

@entity1 @entity706 @entity5 @entity31 @entity1892 @entity14 @entity1412
Primary @entity14 accounts for only about 0.2% of large intestinal @entity5 . Management difficulties are compounded by a lack of consistent pathological reporting and by the use of numerous different classifications. Forty-five cases of primary @entity14 are included in this study. The presenting features are indistinguishable from those of @entity14 . Seven @entity1 had a history of chronic @entity31 but no other predisposing factors were identified. Immunohistochemical studies showed that all @entity5 were of B-cell phenotype. Most @entity5 were difficult to characterize using standard pathological classifications such as Kiel, except for the 11 cases of malignant (multiple) @entity1412 , which were morphologically diffuse @entity706 . Twenty-nine @entity706 showed the morphological and immunohistochemical features associated with @entity5 arising in mucosa-associated lymphoid tissue. These @entity5 showed variable but often marked polymorphism and we have used the term polymorphic @entity1892 to describe them. Consistency was achieved between three observers as to whether these @entity5 were low or high grade, and grade was found to be prognostically important. A modified Dukes staging system was adopted and there was a trend for early stage to give prognostic advantage. This study supports the view that surgery should be the primary treatment for @entity706 of the gastrointestinal tract with radiotherapy and/or chemotherapy for advanced cases and for @entity1412 .
