@entity6948 as an Anesthetic Adjuvant in XXXX Undergoing Transsphenoidal Resection of @entity977 .

@entity1 @entity101 @entity9170 @entity548 @entity3369 @entity591 @entity977 @entity1875 @entity3612 @entity5161 @entity6948 @entity3575
BACKGROUND: Transnasal transsphenoidal (TNTS) resection of @entity977 involves wide fluctuation in hemodynamic parameter and causes @entity101 and @entity591 due to intense noxious stimuli during various stages of surgery. None of routinely used anesthetic agents effectively blunts the undesirable hemodynamic responses, and therefore usually there is a need to use increased doses of anesthetic agents. @entity6948 ( @entity9170 ) an a-2 adrenergic receptor agonist, because its sympatholytic and antinociceptive properties may ensure optimal intraoperative hemodynamic stability during critical moments of surgical manipulation. In addition, @entity9170 reduced the anesthetic requirement with rapid recovery at the end of surgery. The main aim of our study was to evaluate the effect of @entity9170 on perioperative hemodynamics, anesthetic requirements, and recovery characteristics in @entity1 undergoing TNTS resection of @entity977 . MATERIALS AND METHODS: Forty-six @entity1 scheduled for elective TNTS resection of @entity977 were randomized to receive a continuous infusion of @entity9170 (group D) or 0.9% saline (group C). @entity1 in both the groups were subjected to a standardized anesthesia comprising of induction with @entity1875 , @entity3575 , @entity3369 , and positive pressure ventilation with @entity3612 /air (1:1)/ @entity5161 . The response entropy target range during maintenance of anesthesia was 40 to 60. The hemodynamic variables at various stages of surgery, intraoperative anesthetic, and analgesic and recovery characteristics were recorded. RESULTS: Total @entity3575 consumption during the study period was significantly lower in group D compared with group C (4.7 and 7.7   g/kg, respectively; P<0.01). End-tidal @entity5161 concentration requirement was found to be significantly reduced in group D compared with group C throughout the surgical period. @entity3575 and end-tidal @entity5161 concentration requirement was reduced in group D compared with group C by 40% and 33.3%, respectively. Heart rate and mean arterial pressure were significantly higher in the group C compared with group D after intubation, during various stages of surgery and immediately after extubation. The group D had excellent surgical conditions and lesser @entity548 in comparison to group C. Emergence time and extubation time were significantly shorter in group D compared with group C. CONCLUSIONS: @entity9170 as an anesthetic adjuvant improved hemodynamic stability and decreased anesthetic requirements in @entity1 undergoing TNTS resection of @entity977 . In addition, @entity9170 provided better surgical field exposure conditions and early recovery from anesthesia.
