XXXX and the risk of institutionalization and @entity204 : the aging, demographics, and memory study.

@entity1 @entity308 @entity283 @entity146 @entity73 @entity147 @entity1833 @entity148 @entity2146 @entity4943 @entity204
OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and @entity204 . DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). @entity1 : Five hundred thirty-seven adults aged 71 and older with @entity73 drawn from the @entity283 ( @entity283 ). MEASUREMENTS: @entity146 (delusions, @entity1833 , @entity2146 , @entity308 , apathy, elation, @entity148 , @entity4943 , @entity146 , and aberrant motor behaviors) and @entity147 were identified using the Neuropsychiatric Inventory. A consensus panel in the ADAMS assigned cognitive category. Date of nursing home placement and information on @entity204 , functional limitations, medical comorbidity, and sociodemographic characteristics were obtained from the @entity283 and ADAMS. RESULTS: Overall, the presence of one or more neuropsychiatric symptoms was not associated with a significantly higher risk for institutionalization or @entity204 during the 5-year study period, although when assessing each symptom individually, @entity308 , delusions, and @entity2146 were each associated with a significantly higher risk of institutionalization (hazard rate (HR)=3.06, 95% confidence interval (CI)=1.09-8.59 for @entity308 ; HR=5.74, 95% CI=1.94-16.96 for clinically significant delusions; HR=4.70, 95% CI=1.07-20.70 for clinically significant @entity2146 ). Caregiver distress mediated the association between delusions and @entity2146 and institutionalization. @entity308 and @entity1833 were associated with significantly higher mortality (HR=1.56, 95% CI=1.08-2.26 for @entity308 ; HR=2.59, 95% CI=1.09-6.16 for clinically significant @entity1833 ). CONCLUSION: Some, but not all, neuropsychiatric symptoms are associated with a higher risk of institutionalization and @entity204 in @entity1 with @entity73 also influences institutionalization. Interventions that better target and treat @entity308 , delusions, @entity2146 , and @entity1833 , as well as @entity147 , may help delay or prevent these negative clinical outcomes.
