XXXX -induced @entity2359 in adults.

@entity1 @entity146 @entity75 @entity4581 @entity2929 @entity177 @entity1245 @entity1729 @entity302 @entity933 @entity159 @entity2359
@entity4581 is a relatively new antibiotic of the macrolide family heralded for an improved side effect profile, dosing schedule, and microbiological activity relative to its parent compound, @entity2929 . We review the literature on @entity4581 -induced @entity2359 in adults and present an illustrative case. A total of 38 @entity1 with @entity4581 -induced @entity2359 have been reported. The average age of @entity1 was 51.3 years (range: 19-87 years) with females comprising 52.6% of @entity1 . @entity146 was the most common comorbidity, while only two @entity1 had @entity177 . @entity4581 had been prescribed for @entity1729 in most @entity1 , and only two @entity1 were receiving more than 1000 mg/day of antibiotic. The symptoms started 1 day to 10 days after starting @entity4581 (mean: 5 days). A total of 71% of @entity1 were under treatment with concomitant medication, and eight @entity1 were undergoing treatment with psychoactive drugs. @entity1 had a very good outcome after @entity4581 was discontinued, but medication with neuroleptics or @entity1245 was required for 58% of @entity1 in the acute phase. Only four @entity1 underwent an electroencephalogram (EEG). Our illustrative @entity1 was a 74-year-old @entity1 with @entity4581 -induced @entity933 due to @entity159 ( @entity159 ). Her clinical symptoms and electroencephalogram (EEG) readings dramatically improved after discontinuation of @entity4581 . The mechanism underlying the central nervous system side effects remains unclear. We suggest including an EEG in the diagnostic procedures of @entity1 under treatment with @entity4581 who develop features of @entity2359 because an EEG can help to differentiate @entity1 with @entity146 from those with @entity75 or @entity302 . Because of the widespread use of @entity4581 , clinicians should be aware of its @entity2359 . Early detection of @entity4581 -induced @entity2359 and discontinuation of the drug may result in full recovery.
