Four-locus gene interaction between @entity4047 , @entity3646 , @entity19144 , and @entity2162 for XXXX in Chinese Han @entity1 .

@entity748 @entity1 @entity2162 @entity17357 @entity9597 @entity4047 @entity16212 @entity72113 @entity565 @entity19144 @entity3646 @entity61610
RATIONALE: @entity4047 , @entity3646 , @entity9597 , @entity19144 , and @entity2162 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity748 @entity1 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity748 @entity1 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity4047 @entity16212 , @entity3646 @entity17357 , @entity2162 @entity72113 , and @entity19144 @entity61610 was chosen as the optimal one for determining @entity565 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity565 (G allele of @entity16212 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity17357 , OR   =   1.25, P   =   3.81E-03; A allele of @entity72113 , OR   =   1.29, P   =   6.75E-05; G allele of @entity61610 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity16212 GG, @entity17357 TT, @entity72113 AA, and @entity61610 GG) had a significantly higher risk of @entity565 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity4047 @entity16212 , @entity3646 @entity17357 , @entity2162 @entity72113 , and @entity19144 @entity61610 , four SNPs with significant sole effect on @entity565 , interact to confer a higher risk for the disease in Chinese Han @entity1 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.
