[Systemic XXXX : epidemiology and diagnostic criteria].

@entity1 @entity6831 @entity5132 @entity281 @entity1398 @entity397
Among the systemic @entity281 , @entity6831 is the most frequent and is constantly on the increase. Candidiasis occurs in @entity1 with particular risks, i.e., in oncologic @entity1398 @entity1 and in surgical @entity1 after intraabdominal surgery. Independent predictive factors are multiple prior antibiotic therapy, the presence of intravascular devices and previous colonization by Candida, as well as the @entity397 of skin or cutaneous anatomical barriers. @entity5132 is still the predominant species. Diagnosis of @entity6831 is difficult and sometimes delayed. It relies essentially on a high index of suspicion, on blood cultures and the analysis of other samples (biopsies) by a combination of microbiological and anatomopathological procedures. The detection of Candida antigens, antibodies or metabolites still suffers from suboptimal sensitivity and specificity. Molecular diagnosis by amplification (PCR) is promising. The reservoir of Candida is mainly the @entity1 digestive tract, and a colonization stage usually precedes an established @entity281 . Transmission of Candida by @entity1 carriage or through the environment could play an important role, particularly in intensive care units.
