Whole abdominal radiation as salvage therapy for XXXX .

@entity1 @entity43 @entity66 @entity102 @entity1744
Thirty @entity1 found to have @entity43 at second-look laparotomy were treated with whole abdominal radiation as salvage therapy. Dosage fractions were 120 rad per day until 3000 rad were delivered, then the pelvis was boosted to 5000 rad at 180 rad per day. Fourteen @entity1 (47%) completed therapy without interruption and seven (23%) completed therapy with interruptions due to myelosuppression ranging from one to four weeks. Therapy was not completed in nine @entity1 (30%). Four of 16 @entity1 (25%) with microscopic @entity66 before radiation remain alive and free of disease at 22 to 41 months. Two of six (33%) @entity1 with minimal (less than or equal to 5 mm) @entity66 remain alive and free of disease 19 to 40 months after radiation treatment. @entity1 with residual nodules greater than 5 mm uniformly did poorly. @entity1 who progressed on primary chemotherapy had a median survival of seven months, compared with more than 38 months for chemotherapy responders. @entity102 was a significant problem, with 30% of @entity1 surviving at least four months from completion of radiation requiring laparotomy for @entity1744 . These preliminary results suggest that whole abdominal radiation may be useful in the management of @entity1 who have responded to primary chemotherapy, but the benefit is confined to those @entity1 who have minimal or microscopic disease at second-look laparotomy.
