Impact of Neuropsychiatric Symptoms on the Quality of Life of Subjects with  XXXX .

@entity1 @entity146 @entity191 @entity23 @entity716
BACKGROUND: @entity146 in @entity191 ( @entity191 ) are frequent. Impact of @entity146 on quality of life has recently become a relevant topic of research due to its potential to develop targeted therapies to improve quality of life. OBJECTIVE: To determine the impact of @entity146 in @entity1 with @entity191 using the Parkinson's DiseaseQuestionnaire Short Form (PDQ-8). METHODS: Consecutive @entity1 with @entity191 were evaluated with the @entity191 ( @entity191 ) and PDQ-8 scales separately. Association between @entity146 and quality of life was explored using, means comparisons, correlation coefficients and multiple regression models. RESULTS: A total of 492 @entity1 were included for the study. Overall, 44.5% had @entity716 symptoms, 76.5% had alterations on mood/apathy domains, and 27% had an @entity23 . All @entity146 had an effect on the PDQ-8 with a moderate to large effect size. Correlation coefficients ranged from 0.17 to 0.63 between @entity146 and quality of life (p< 0.001, in all cases). The regression model showed that mood/apathy alterations and impulse control disorders, along with MDS-UPDRS III accounted for 49.8% of variance in the PDQ-8 simplified index (F=122.98; p< 0.001). Mood/apathy alterations showed the highest correlation coefficient (0.63, p< 0.001) and b (0.53, p< 0.001). CONCLUSIONS: Both the presence and severity of @entity146 , in particular mood/apathy alterations,had  a  significant impact on quality of life in subjects with @entity191 .
