XXXX index and mortality: the Cremona study in the 15th year of follow-up.

@entity1560 @entity6 @entity5 @entity409 @entity412 @entity204 @entity65
A @entity1560 , which is a common feature in insulin-resistant states, can lead to @entity409 . It has been hypothesized that a @entity1560 can also increase the rates of non-hepatic-related morbidity and mortality. Therefore, we wanted to determine whether the @entity1560 index (FLI), a surrogate marker and a validated algorithm derived from the serum @entity412 level, body mass index, waist circumference, and y-glutamyltransferase level, was associated with the prognosis in a population study. The 15-year all-cause, hepatic-related, @entity65 ( @entity65 ), and @entity5 mortality rates were obtained through the Regional Health Registry in 2011 for 2074 Caucasian middle-aged individuals in the Cremona study, a population study examining the prevalence of @entity6 in Italy. During the 15-year observation period, 495 @entity204 were registered: 34 were hepatic-related, 221 were @entity65 -related, 180 were @entity5 -related, and 60 were attributed to other causes. FLI was independently associated with the hepatic-related @entity204 (hazard ratio = 1.04, 95% confidence interval = 1.02-1.05, P < 0.0001). Age, sex, FLI, cigarette smoking, and @entity6 were independently associated with all-cause mortality. Age, sex, FLI, systolic blood pressure, and fibrinogen were independently associated with @entity65 mortality; meanwhile, age, sex, FLI, and smoking were independently associated with @entity5 mortality. FLI correlated with the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (Spearman's    = 0.57, P < 0.0001), and when HOMA-IR was included in the multivariate analyses, FLI retained its association with hepatic-related mortality but not with all-cause, @entity65 , and @entity5 -related mortality. CONCLUSION: FLI is independently associated with hepatic-related mortality. It is also associated with all-cause, @entity65 , and @entity5 mortality rates, but these associations appear to be tightly interconnected with the risk conferred by the correlated insulin-resistant state.
