A solution to the negative effects of splenectomy during colorectal XXXX and surgery: an experimental study on splenic autotransplantation to the groin area.

@entity1 @entity254 @entity720 @entity14 @entity35 @entity130
BACKGROUND: Splenectomy after combined colosplenic @entity130 or iatrogenic @entity130 during colorectal surgery associates with worse short- and long-term outcomes, including reduced survival in @entity1 with @entity14 . Splenic autotransplantation may improve the outcomes of such @entity1 . Omental splenic transplantation is the standard procedure but may be difficult when performing laparoscopic colorectal surgery or when total or subtotal omentectomy is required. This animal model study was performed to evaluate the impact of splenic autotransplantation to the groin area on colonic wound healing. METHODS: Thirty @entity35 were divided into three groups of ten animals. One group underwent colon @entity254 and sham splenectomy, the second underwent colon @entity254 and splenectomy, and the third underwent colon @entity254 , splenectomy, and intramuscular autotransplantation of the spleen. On postoperative day 7, anastomotic healing was evaluated by measuring bursting pressure and @entity720 levels. The third group was subjected to scintigraphy before sacrifice to assess whether the transplant was functional. RESULTS: The mortality rates of the sham, splenectomized, and transplanted animals were 0 %, 30 %, and 20 %, respectively: the splenectomized animals had significantly lower mean bursting pressures than the other two groups (p   =   0.002). The mean @entity720 levels of the three groups were 467.4, 335.3, and 412.7 mg @entity720 /g protein, respectively (p   =   0.0856). Nine of the ten transplanted animals (90 %) had splenic activity on scintigraphy. CONCLUSIONS: Splenectomy impaired the healing of the colonic @entity254 . This effect was largely reversed by splenic autotransplantation. Intramuscular autotransplantation to the groin area appears to be feasible and effective.
