Impact of clinical parameters on the diagnostic accuracy of endorectal coil MRI for the detection of XXXX .

@entity5 @entity1 @entity263
OBJECTIVES: Endorectal coil MRI (endoMRI) of the prostate is useful to evaluate @entity5 localization. There is little evidence on @entity1 characteristics affecting its diagnostic performance. We evaluate the influence of clinical and histological parameters on the accuracy of endoMRI. METHODS: Sixty-nine @entity1 with @entity263 were included. After virtually dividing the prostate into pixels of 1 cm2, results of endoMRI were compared with those from prostatectomy specimens' whole-mount sections. Univariate and multivariate analyses were performed to calculate the impact of clinical and histological parameters on the number of appropriately described pixels. RESULTS: In 9, no @entity5 could be demonstrated by endoMRI. 48.3% of @entity1 were staged correctly, 23.3% were over- and 28.3% understaged. Mean rates of correctly labeled pixels were 0.44 (   0.04 SEM) for @entity5 and 0.90 (   0.01) for benign segments. In univariate analysis, the rate of correctly labeled @entity5 segments showed significant positive correlations with Gleason score >= 7 and negative correlations with prostate weight and multifocality. The rate of correctly labeled benign segments showed significant negative correlation with @entity5 weight. All factors were independent variables in multivariate analysis. CONCLUSIONS: The reliability of endoMRI depends on clinical parameters. Higher Gleason scores, unifocal @entity5 and smaller prostate volumes ameliorate endoMRI performance.
