Vasospastic individuals demonstrate significant similarity to @entity726 XXXX as revealed by gene expression profiling in circulating leukocytes.

@entity1 @entity1952 @entity455 @entity16 @entity726
PURPOSE: There is growing evidence that vasospatic individuals could be predisposed to develop @entity726 . Vasospastic deregulation is ensuing in activation of circulating leukocytes. In previous studies using "gene-hunting" strategies, we demonstrated stable alterations in gene expression profiles of circulating leukocytes isolated from @entity726 @entity1 with @entity455 when compared to healthy individuals with no history of @entity16 . The goal of this study was to look for possible similarities in gene expression profiles of circulating leukocytes in vasospastic individuals and @entity726 @entity1 . METHODS: Normal-tension (NTG) and high-tension (HTG) @entity726 @entity1 as well as individuals with @entity455 ( @entity455 ) and healthy controls were recruited for the gene expression analysis. The methodology of comparative Expression Array analysis followed by highly sensitive quantitative real-time PCR has been used. RESULTS: Compared to the control group the expression of 146, 68, and 60 genes was found to be altered in NTG, HTG, and @entity455 groups respectively. Thirty-four genes demonstrated similar expressional alterations in NTG, HTG, and @entity455 groups versus controls, and only 21 genes demonstrated similar expressional alterations in NTG and HTG groups, having no overlap with the @entity455 group. CONCLUSIONS: This result indicates a potential predisposition of vasospastic individuals to glaucomatous @entity1952 . The targeted expression profiles might be further considered for early/predictive @entity726 diagnosis.
