The effect of systemic antibiotic prophylaxis for cirrhotic XXXX with peptic @entity1066 after endoscopic interventions.

@entity1 @entity2756 @entity82 @entity548 @entity1066 @entity281 @entity204
PURPOSE: All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic @entity1 with either a mixture of nonvariceal and variceal @entity548 or variceal @entity548 alone. Reports on sole peptic ulcers @entity548 are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic @entity1 with peptic @entity1066 after endoscopic interventions and the risk factors associated with recurrent @entity548 . METHODS: A cross-sectional retrospective chart review study was conducted on 148 cirrhotic @entity1 with acute peptic ulcer @entity548 who underwent therapeutic endoscopic procedures. @entity1 who received prophylactic intravenous @entity2756 were classified as group A (n  =  38) and those who did not receive antibiotics were classified as group B (n  =  110). The outcomes were prevention of @entity281 , length of hospital stay, time of rebleeding, and @entity204 . RESULTS: More @entity1 suffered from recurrent @entity548 and @entity281 in group B than those in group A (28.2 vs. 5.3  %; p  =  0.003, and 26.4 vs. 10.5  %; p  =  0.043, respectively). The risk factors associated with recurrent @entity548 were being male (OR  =  3.4; p  =  0.024), those with advanced stage of @entity82 with @entity1 -Pugh's class C (OR  =  3.8; p  <  0.001), and those without antibiotic prophylaxis (OR  =  8.9; p  =  0.003). The observed 30-day survival was virtually identical for both groups (p  =  0.279). CONCLUSIONS: Antibiotic prophylaxis in cirrhotic @entity1 after endoscopic interventions for acute peptic ulcer @entity548 reduced @entity281 and decreased rebleeding. Male gender, @entity82 @entity1 -Pugh's class C, and no antibiotic prophylaxis were independent predictors of recurrent @entity548 . Further studies should be directed to explore ways to improve the overall outcome of these @entity1 .
