Clinical outcomes and factors related to resectability and curability of EMR for early XXXX .

@entity1 @entity308 @entity189 @entity14
BACKGROUND: EMR has emerged as an alternative therapeutic option for selected cases of early @entity14 (ECC). However, the factors associated with resectability and curability of EMR for ECC remain unknown. OBJECTIVE: To investigate clinical outcomes and factors related to resectability and curability in ECC cases treated with EMR. DESIGN: Retrospective study. SETTING: Tertiary-care academic medical center. @entity1 : This study involved all @entity1 in whom EMR was performed for ECC at Severance Hospital between March 1997 and August 2007. A total of 236 cases of ECC occurring in 231 @entity1 (66.2% @entity1 ) were enrolled. INTERVENTION: EMR. Curative surgical resection and lymph node dissection were used in cases that were incompletely cured by EMR. MAIN OUTCOME MEASUREMENTS: Resectability, curability, and recurrence. RESULTS: Complete cure was achieved for 162 lesions (68.6%). Of the remaining 74 cases (31.4%), 69 (29.2%) were incompletely cured, and the other 5 (2.1%) had an undetermined resection status and ultimately required supplementary surgical resection for curative treatment. Location on the right side of the colon, piecemeal resection, and @entity189 were independently associated with incomplete resection, whereas @entity308 type was independently related to incomplete cure. Among the ECC cases completely cured by EMR and followed for more than a year (n = 118), local recurrence was observed in one case (0.8%) during the median follow-up period of 39.4 months (range 12.4-123.1 months). LIMITATIONS: Single-center, retrospective study. CONCLUSION: Our data show that EMR is feasible and could be an effective option for treatment of ECC if the technique is applied with the appropriate indications.
