Intra-operative frozen section diagnosis of XXXX : a retrospective analysis of 13,243 Chinese @entity1 .

@entity1 @entity1377 @entity1137 @entity4122 @entity39 @entity5 @entity2318 @entity1185 @entity3923 @entity1463 @entity982 @entity1271 @entity10923 @entity420 @entity1558
BACKGROUND: Although cytological methods for breast oncology have been used in recent decades, intra-operative frozen section has been playing a vital role in making therapeutic decisions. We analyzed a large series of frozen section diagnoses for Chinese cases of breast lesion within the last 15 years. The experience was expected to increase the diagnostic accuracy of cases with @entity1558 . METHODS: The data from consecutive 13243 cases of @entity1558 diagnosed with intra-operative frozen sections between 1988 to 2002 were compared with @entity982 sections in a case by case manner. The causes of false negative and positive diagnoses as well as delayed diagnoses were analyzed. RESULTS: One hundred and seventeen cases (0.9%) were falsely diagnosed, with one false positive case and 116 false negative cases. The diagnosis of 47 cases (0.4%) was delayed. The proportion of several lesions had the features of the @entity1 ' ages. Six types (false invasion, peri- @entity1185 , @entity10923 , florid @entity3923 , @entity1463 @entity3923 , and granulose cell @entity5 ) of lesions may lead to false positive, and four types (morphological changes responding chemotherapy, well differentiated @entity1377 , @entity1137 , and @entity420 ) to a false negative. Gross and microscopic findings may be inconsistent in two types of lesions ( @entity2318 and florid @entity3923 ) microscopic and clinical findings in three types ( @entity1271 mammary, duct @entity4122 , and fat @entity39 ), and three types (abundant fat or sclerous tissues; borderline lesions and changes of post-chemotherapy) were likely wrongly classified. CONCLUSIONS: Intra-operative frozen section can accurately identify @entity1558 in many instances, leading to fewer errors on account of more diagnostic experience and understanding of diagnostic limitations.
