XXXX and @entity1436 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.

@entity368 @entity10366 @entity1178 @entity750 @entity1436
Basic region @entity368 zipper (bZIP) transcription factors regulate gene expression critical for long-term synaptic plasticity or neuronal excitability contributing to learning and memory. At sensorimotor synapses of Aplysia, changes in activation or expression of @entity10366 and @entity1436 in sensory neurons are required for long-term synaptic plasticity. However, it is unknown whether concomitant stimulus-induced changes in expression and activation of bZIP transcription factors in the postsynaptic motor neuron also contribute to persistent long-term facilitation (P-LTF). We overexpressed various forms of @entity10366 , @entity1436 , or @entity1178 in the postsynaptic motor neuron L7 in cell culture to examine whether these factors contribute to P-LTF. P-LTF is evoked by 2 consecutive days of @entity750 applications (2 @entity750 ), while a transient form of LTF is produced by 1 day of @entity750 applications (1 @entity750 ). Significant increases in the expression of both @entity1178 and @entity1436 mRNA in L7 accompany P-LTF. Overexpressing each bZIP factor in L7 did not alter basal synapse strength, while coexpressing @entity1178 and @entity1436 in L7 evoked persistent increases in basal synapse strength. In contrast, overexpressing @entity1178 and @entity1436 in sensory neurons evoked persistent decreases in basal synapse strength. Overexpressing wild-type @entity1178 or @entity1436 , but not @entity10366 , in L7 can replace the second day of @entity750 applications in producing P-LTF. Reducing @entity1178 activity in L7 blocked P-LTF evoked by 2 @entity750 . These results suggest that expression and activation of different bZIP factors in both presynaptic and postsynaptic neurons contribute to persistent change in synapse strength including stimulus-dependent long-term synaptic plasticity.
