Context-driven changes in XXXX -induced behaviours in the @entity2955 lesioned @entity35 .

@entity1 @entity3034 @entity910 @entity191 @entity35 @entity717 @entity2955
Both @entity717 and @entity910 @entity910 ( @entity910 ) are induced by the administration of @entity3034 in the unilateral @entity2955 lesioned @entity35 model of @entity191 . Since rotational responses can be conditioned to environmental cues we have investigated the extent to which drug-induced AIMS may also be conditioned by exteroceptive cues and experience. In Experiment I, @entity2955 lesioned @entity35 received repeated daily injections of @entity3034 either in their home cage (control) or in association with a brief (20 mins) exposure to the rotometers (paired). To assess conditioning, all animals then received two tests in the rotometer bowls. Following injection of saline the paired group both rotated more contralaterally and displayed manifest @entity910 , neither of which were exhibited by the control @entity35 . Moreover, following injection of @entity3034 , the paired group showed a trend for increased @entity910 compared to controls. Two further studies provided longer exposure to the conditioning environments in counterbalanced designs. Although, using these parameters, re-exposure in the presence of saline did not induce context-dependent @entity910 , a strong context-specific component of the sensitised response to @entity3034 was seen; chronic administration of drug produced a significantly stronger behavioural response in animals paired with a particular environment for drug administration than controls. This data suggests that part of the sensitisation of behavioural responding to @entity3034 administration is not solely a pharmacological phenomenon, but is also conditioned to the environmental context in which the drug is administered. This has clear implications for the clinical observation and experimental measurement of drug-induced @entity910 in @entity191 @entity1 and animal models.
