A New Animal Model to Study Endogenous Cardiotonic @entity230 and the Progression of Cardiovascular Events in Salt-Sensitive XXXX .

@entity230 @entity1 @entity3529 @entity4024 @entity101 @entity231 @entity35
UNASSIGNED: The Dahl salt-sensitive @entity35 is a well-established model to study essential @entity101 . We first described a subgroup of these @entity35 based on the unique response pattern in systolic blood pressure during the first weeks of exposure to a high salt diet that included @entity231 formation. We classified this group as @entity231 -prone Dahl salt-sensitive @entity35 . We also were able to predict and prevent @entity231 formation in these @entity35 . Further studies showed an inhibition of lens @entity4024 , @entity3529 -ATPase activity which may be in part responsible for the @entity231 formation. Other studies in Dahl salt-sensitive @entity35 maintained on a high salt diet have also shown decreased @entity4024 , @entity3529 -ATPase activity in several tissues and increased levels of endogenous circulating @entity4024 , @entity3529 pump inhibitors. For over 20 years, endogenous cardiotonic @entity230 have been postulated to inhibit @entity4024 , @entity3529 -ATPase in both @entity1 as well as in experimental animal models of @entity101 . Recent findings have shown results suggesting that there are several forms of cardiotonic @entity230 with minor differences in structural functionalities, site of production, and specific pump selectivity. We present original data that supports a role for cardiotonic @entity230 in disease progression related to increased salt-sensitivity. We found increased levels of free endogenous cardiotonic @entity230 in those @entity35 that were classified as @entity231 -prone according to their initial systolic blood pressure response to a high salt intake when compared to non- @entity231 prone Dahl salt-sensitive @entity35 and their control Dahl salt-resistant @entity35 . The @entity231 -prone Dahl salt-sensitive @entity35 is an animal model that can help and contribute to open a new door to possibly elucidate the role of endogenous cardiotonic @entity230 in the pathogenesis and progression of diseases related to salt-sensitive @entity101 .
