Effects of Placental Transfusion on Neonatal and 18 Month Outcomes in Preterm XXXX : A Randomized Controlled Trial.

@entity1 @entity295 @entity548 @entity602 @entity1468 @entity13493
OBJECTIVE: To assess the effect of delayed cord clamping (DCC) vs @entity602 ( @entity602 ) on @entity548 ( @entity548 ), late onset @entity295 (LOS), and 18-month motor outcomes in preterm @entity1 . STUDY DESIGN: @entity1 (n  =  208) in labor with singleton fetuses (<32  weeks gestation) were randomized to either DCC (30-45  seconds) or @entity602 (<10  seconds). The primary outcomes were @entity548 , LOS, and motor outcomes at 18-22  months corrected age. Intention-to-treat was used for primary analyses. RESULTS: Cord clamping time was 32      16  (DCC) vs 6.6      6 ( @entity602 ) seconds. @entity1 in the DCC and @entity602 groups weighed 1203      352 and 1136      350  g and mean gestational age was 28.3      2 and 28.4      2  weeks, respectively. There were no differences in rates of @entity548 or LOS between groups. At 18-22  months, DCC was protective against motor scores below 85 on the Bayley Scales of @entity1 Development, Third Edition (OR 0.32, 95% CI 0.10-0.90, P  =  .03). There were more @entity1 with @entity1468 in the @entity602 group (37% vs 22%, P  =  .02) and more @entity1 in the DCC group with premature @entity13493 (54% vs 75%, P  =  .002). @entity1468 halved the risk of @entity548 (OR 0.50, 95% CI 0.2-1.0) and premature @entity13493 doubled the risk of @entity548 (OR 2.0, 95% CI 1.2-4.3). CONCLUSIONS: Although DCC did not alter the incidence of @entity548 or LOS in preterm @entity1 , it improved motor function at 18-22  months corrected age. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov: NCT00818220 and NCT01426698.
