Low-grade cribriform XXXX of the palatal gland: A case report.

@entity1 @entity5 @entity3928 @entity4206 @entity4483 @entity3 @entity7157
UNASSIGNED: Low-grade cribriform @entity7157 (LGCCC) is a @entity5 . LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female was referred to Saitama Medical University Hospital (Moroyama, Saitama, Japan) due to an intraoral mass. Since cytological examination and biopsy led to a diagnosis favoring a @entity5 , but with uncertain malignant potential, the @entity5 was resected with a safe surgical margin. The specimen was thoroughly examined. Microscopically, there was a well-demarcated, unilocular cyst with the lumen lined by @entity5 cells. The @entity5 cells were arranged in tubular, cribriform and solid structures in the area of the intracystic mass lesions. Nuclear atypia was inconspicuous, although mitotic figures were observed throughout the @entity5 . Neither local nor perineural invasion was present. On immunohistochemistry, the @entity5 cells were diffusely positive for @entity4483 protein. Myoepithelial markers, calponin and @entity4206 , highlighted the cells rimming the @entity3928 . The final histopathological diagnosis was of LGCCC. The @entity5 was completely resected. At 1 year post-resection, the @entity1 exhibited no recurrence or distant @entity3 . LGCCC is regarded as clinically indolent. However, there is little literature available to aid with prognosis prediction due to the rarity of LGCCC cases. Thus, greater experience and longer follow-up periods are necessary to find the optimal/curative treatment for @entity1 with LGCCC and to clarify the pathophysiology.
