Impact of sex differences in brain response to @entity281 with XXXX .

@entity32 @entity66 @entity548 @entity19 @entity935 @entity1425 @entity2041 @entity281 @entity5895 @entity750 @entity311 @entity1063 @entity2637
UNASSIGNED: @entity311 is considered to be one of the most @entity66 in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to @entity281 with @entity2637 . Male and female C57Bl/6 @entity19 were infected with @entity2637 -infected erythrocytes. The @entity281 induced a significant change in weight loss in males (-7.2  %        0.5) than females (-4.9  %        0.6). The maximum @entity5895 reached about 15  % at day 9 postinfection. Also, @entity2637 @entity281 caused histopathological changes in the brain of @entity19 . These changes were in the form of @entity32 , @entity548 , and structural changes in Purkinje cells. In addition, @entity2637 was able to induce a marked oxidative damage in @entity19 brain. The @entity281 induced a significant increase in male brain @entity2041 than females while the brain catalase level was significantly increased in infected females than infected males. Moreover, the change in brain neurotransmitters, @entity935 , @entity1425 , @entity1063 , and @entity750 , was more in infected males than infected females. At the molecular level, @entity2637 was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of @entity19 . These genes were significantly upregulated in infected males than in infected females. In general, @entity2637 could induce structural, biochemical, and molecular alterations in @entity19 brain. Severity of these alterations was different according to sex of @entity19 .
