Followup interval prostate biopsy 3 years after diagnosis of high grade @entity5436 is associated with high likelihood of XXXX , independent of change in @entity1486 levels.

@entity1 @entity1486 @entity263 @entity5436
PURPOSE: Repeat biopsy has been advocated following the diagnosis of high grade @entity5436 to exclude coexisting @entity263 . We further define the natural history of high grade @entity5436 by determining the incidence of @entity263 3 years following diagnosis. MATERIALS AND METHODS: A total of 31 @entity1 underwent followup interval biopsy 3 years after high grade @entity5436 diagnosis in 1996 to 1997, regardless of change in serum @entity1486 ( @entity1486 ) or digital rectal examination findings. A single pathologist reviewed all biopsy specimens. All @entity1 had a minimum of 12 biopsy cores taken at the time of diagnosis. RESULTS: A 3-year followup interval biopsy eight (25.8%) @entity1 had @entity263 , 11 (35.5%) had high grade @entity5436 only and 12 (38.7%) had no disease. Mean serum @entity1486 at diagnosis and before the followup biopsy was 6.88 and 9.69 ng./dl., respectively (p = 0.008). Of the @entity1 48% had less than a 1.0 unit increase in serum @entity1486 . Upon univariate regression analysis change in serum @entity1486 was not associated with the detection of @entity263 (p >0.10). All 4 @entity1 who subsequently underwent radical prostatectomy had organ confined disease. CONCLUSIONS: In a high proportion of @entity1 with high grade @entity263 will develop in a 3-year interval. Our findings support the concept that high grade @entity5436 is a precursor to @entity263 and that repeat biopsy at a delayed interval is recommended regardless of changes in @entity1486 .
