The influence of beta-adrenoceptor blockers with and without intrinsic sympathomimetic activity on heart rate, XXXX and ST-T segments, using ambulatory electrocardiography.

@entity1169 @entity1 @entity308 @entity296 @entity7690 @entity5749 @entity1540 @entity1167 @entity943
1. Ambulatory electrocardiography was used to compare the effects of @entity1169 and @entity7690 on symptoms, heart rate, @entity943 and ST segments. Seventeen males (mean age 54 years) with a diagnosis of @entity5749 (New York Heart Association Class II-III) were studied. @entity1 were treated on a double-blind cross-over basis with @entity1169 80 mg three times daily or @entity7690 5 mg three times daily for 14 days each. During the last 48 h of each treatment period ambulatory electrocardiography was performed. 2. @entity1169 resulted in a significantly lower mean hourly, mean 24 h and minimum heart rate. Likewise @entity1169 caused a lower mean daytime and nocturnal heart rate. There was no significant difference in the frequency of angina between the treatments. The number of episodes of @entity308 was not significantly different between the two drugs, although there was a trend in favour of @entity1169 . 3. Both the mean 24 h ST level and the maximum @entity308 were lower during treatment with @entity7690 . @entity1169 was associated with a total of 117 nocturnal pauses or episodes of @entity1167 ranging in length from 1.5 to 2.8 s. During treatment with @entity7690 only one such period occurred. The number of @entity1540 occurring during treatment with @entity7690 (1316 beats) was less than on @entity1169 (2010) and the mean hourly frequency of @entity1540 was significantly lower during @entity7690 administration. 4. @entity7690 is not significantly different from @entity1169 in the control of symptomatic and asymptomatic @entity296 and is associated with fewer @entity1540 . However, there is no advantage in using @entity7690 in @entity5749 .
