Enhanced epithelial to mesenchymal transition (EMT) and upregulated @entity517 in ectopic lesions contribute independently to XXXX .

@entity172 @entity1 @entity4245 @entity75 @entity5962 @entity219 @entity517 @entity19099 @entity46 @entity8945
BACKGROUND: Epithelial to mesenchymal transition (EMT) is a process in which epithelial cells lose polarity and cell-to-cell contacts and acquire the migratory and invasive abilities of mesenchymal cells. These abilities are thought to be prerequisites for the establishment of @entity75 . A hallmark of EMT is the functional loss of @entity5962 ( @entity5962 ) expression in epithelial cells. @entity8945 , a transcription factor that represses @entity5962 transcription, is among the EMT inducers. @entity4245 , a @entity219 -finger transcription factor, and its close relative @entity19099 have similar properties to @entity8945 and are thus also EMT inducers. @entity517 , which is upregulated by @entity172 in the uterus by an @entity172 response cis-acting element (ERE) in its promoter, is associated with proliferation in @entity46 . The role of EMT and proliferation in the pathogenesis of @entity46 was evaluated by analyzing @entity8945 , @entity5962 and @entity517 expression. METHODS: @entity5962 , @entity8945 , @entity4245 and @entity19099 mRNA expression was analyzed by qRT-PCR from 47 controls and 74 @entity1 with @entity46 . Approximately 42 ectopic and 62 eutopic endometrial tissues, of which 30 were matched samples, were collected during the same surgical procedure. We evaluated @entity8945 and @entity517 protein expression by immunohistochemistry (IHC) in the epithelial and stromal tissue of 69 eutopic and 90 ectopic endometrium samples, of which 49 matched samples were analyzed from the same @entity1 . Concordant expression of @entity8945 / @entity4245 / @entity19099 and @entity5962 but also of @entity8945 and @entity517 was analyzed. RESULTS: We found that @entity8945 , @entity4245 and @entity19099 are overexpressed (p   <   0.001, p   =   0.016 and p   <   0.001) in @entity46 , while @entity5962 expression was concordantly reduced in these samples (p   <   0.001). Similar to @entity8945 , the epithelial expression of @entity517 was also significantly enhanced in ectopic endometrium compared to eutopic tissues (p   =   0.008). We found exclusive expression of either @entity8945 or @entity517 in the same samples (p   =   0.003). CONCLUSIONS: Epithelial @entity8945 is overexpressed in @entity46 and may contribute to the formation of @entity75 by inducing epithelial to mesenchymal transition, as @entity5962 was reduced in ectopic lesions. We found exclusive expression of either @entity8945 or @entity517 in the same samples, indicating that EMT and proliferation contribute independently of each other to the formation of @entity75 .
