XXXX and left ventricular mass in a @entity35 model of isolated systolic @entity101 .

@entity101 @entity35 @entity3875 @entity1239 @entity2647 @entity460 @entity2333 @entity4687
We tested whether cardiac mass can be related to decreased @entity2333 in an original @entity35 model of isolated systolic @entity101 . Increased @entity2333 was produced by @entity460 overload of elastic arteries after @entity3875 plus @entity1239 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity4687 (1 mg/kg per day PO). @entity35 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity2647 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity3875 plus @entity1239 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity4687 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity460 overload of the elastic arteries. In this model of isolated systolic @entity101 , we showed that cardiac mass is related to arterial elasticity.
