Electrical stimulation of the brain for relief of intractable XXXX due to @entity5 .

@entity1 @entity5 @entity158
Seventeen @entity1 with intractable @entity158 due to progressive @entity5 were treated by electrical stimulation of the brain after more conventional @entity158 therapies applied in the University of California, Los Angeles @entity5 Clinic had failed. Electrodes were stereotactically implanted under local anesthesia in the periaqueductal grey (PAG) or periventricular grey (PVG) in 11 @entity1 . In six @entity1 electrodes were placed in both PAG-PVG targets and in the sensory thalamic nuclei. Thirteen of the 17 @entity1 achieved virtually total @entity158 relief and 2 others achieved partial @entity158 relief. At the hospital discharge only 4 of 17 @entity1 required narcotic analgesics for @entity158 relief. Follow-up periods ranged from 1 to 21 months and 6 @entity1 remain alive. Fourteen @entity1 eventually required narcotics for @entity158 relief, usually in the terminal few weeks of their lives. @entity158 relief was achieved in spite of the fact that all @entity1 were tolerant to large doses of systematically or intraspinally administered narcotics at the time of electrode placement. No complications related to brain stimulation were identified. Brain stimulation is a safe and effective method for treatment of intractable @entity158 due to @entity5 in certain @entity1 .
