XXXX gene polymorphisms confer Beh  et's disease in Turkish population.

@entity1 @entity3646 @entity9597 @entity195
Several cytokine genes may play crucial roles in host susceptibility to @entity195 ( @entity195 ), because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the @entity3646 and @entity9597 gene polymorphisms with the susceptibility to @entity195 was investigated in this study. DNA samples were obtained from a Turkish population of 97 @entity1 with @entity195 and 76 healthy control subjects. All genotyping ( @entity3646 and @entity9597 ) experiments were performed using PCR sequence-specific primers. When compared with the healthy controls, the frequency of @entity3646 -1098 TG and -590 CT genotypes was higher in the @entity1 with @entity195 . Analysis of allele frequencies showed that @entity3646 -1098   G and @entity3646 -590 T alleles were more common in the @entity1 with @entity195 when compared with healthy controls. Also, @entity3646 TTC and haplotypes were found to confer @entity195 . Interestingly, we demonstrated that @entity9597 gene polymorphism seems to be associated with the Pathergy test positivity in @entity1 with @entity195 . Our data suggest that @entity3646 gene promoter polymorphisms may affect susceptibility to @entity195 and increase risk of developing the disease. However, in order to confirm and assess the association of @entity3646 and @entity9597 gene polymorphisms with the @entity195 , large cohort studies are needed.
