Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in XXXX .

@entity43 @entity1 @entity66 @entity7 @entity5 @entity843 @entity876 @entity2247
OBJECTIVES: This study examines whether expression of @entity2247 is associated with clinicopathological features and other molecular markers of @entity43 . METHODS: Sixty-four paraffin-embedded tissue specimens were obtained from @entity1 with @entity43 who received cytoreductive surgery and combination chemotherapy. Tissue specimens were subjected to immunohistochemical analysis using antibodies to @entity2247 , @entity876 , and @entity7 . RESULTS: Increased @entity2247 expression significantly correlated with histologic type (mucinous 5.6% vs. non-mucinous 65.2%, P<0.001). @entity2247 expression was also significantly associated with stage, @entity5 grade, @entity66 status, and presence of @entity843 . @entity2247 expression correlated positively with expression of @entity876 (P=0.006) and @entity7 (P=0.025). Although survival was lower in @entity1 with high @entity2247 expression than in those without high @entity2247 expression (P<0.001), only @entity5 grade and stage were independent prognostic indicators. In @entity1 with @entity5 , @entity2247 expression correlated with stage (P<0.001) and presence of @entity843 (P=0.033). CONCLUSIONS: Our results suggest that expression of @entity2247 in @entity43 is specific to histologic type of @entity5 and is associated with poor clinicopathologic prognostic factors. Expression of @entity2247 also correlates well with expression of @entity876 and @entity7 .
