XXXX of the Old World.

@entity1 @entity2348 @entity2878 @entity3667 @entity4536 @entity8201
@entity4536 is a vector-borne @entity2878 of the skin. Several species of @entity3667 cause this disease in the Old World. It is manifested as chronic nodular to ulcerative lesions of the skin, which last for many months and may be disfiguring. They eventually heal leaving a scar. Local care of the lesion and treatment of secondary @entity2348 are essential for healing. Antileishmania therapy is indicated in immunocompromised hosts, @entity1 with progressive, multiple, or critically located lesions. Pentavalent antimony compounds remain the main therapeutic option for all species. They are given intravenously (i.v.), intramuscularly (i.m.), or intralesionally. Cryotherapy, and some systemic antifungal agents have been used successfully. Oral @entity8201 are promising new treatments for lesions caused by @entity3667 . Several other alternatives and their evidence are also presented.
