Does maternal drug ingestion cause megacystis microcolon intestinal hypoperistalsis syndrome? II. XXXX trial.

@entity1 @entity23454 @entity66 @entity1494 @entity13312 @entity35 @entity2057 @entity4001
PURPOSE: @entity23454 ( @entity23454 ) is a @entity66 , and the etiology of the disease is unclear. It is speculated that maternal ingestion of some drugs during pregnancy and degeneration of smooth muscle cells in the fetus may be an etiologic factor. In this study we aimed to investigate the effect of maternal ingestion of @entity4001 on the fetal bladder and colon in pregnant @entity35 . METHOD: We separated animals into a @entity4001 group including 30 @entity35 and a control group with 14 @entity35 . Nothing was given to the control group during pregnancy. Intraperitoneally 8 mg/kg/day @entity4001 was given to the study group from the 6th to 12th day of pregnancy. All of the @entity35 were sacrificed on the 20th day of pregnancy. Histopathological examination of fetal colons and bladders was performed. RESULTS: In the @entity4001 group, an increase in the colon and bladder diameter, an increase in @entity2057 in the colon and bladder wall, an increase in @entity13312 in the muscles of the bladder and colon wall, and a significant @entity1494 were determined. CONCLUSION: In our @entity35 model, we found histological structural changes in the @entity35 ' colon and bladder walls as a result of using @entity4001 on the 6-12th days of pregnancy similar to pathological findings found in some of @entity23454 @entity1 ' bowels and bladders.
