Evaluation and outcome of XXXX in older and younger adults.

@entity1 @entity644 @entity8 @entity230 @entity1987 @entity101 @entity2316 @entity628 @entity1011
BACKGROUND: The spectrum of @entity8 in older adults remains incompletely defined. The purpose of the present study was to determine if differences exist in diagnostic approach, etiology, therapy, and outcome between older (> or = 60 years) and younger (<60 years) @entity1 referred for evaluation of @entity644 . METHODS: We conducted a retrospective review of outpatient office charts in a 7-physician, hospital-based nephrology practice. RESULTS: We identified 69 @entity1 with at least 1 subsequent follow-up assessment after reviewing approximately 500 sequential charts. Forty-five were younger (mean +/- SD age, 38 +/- 2 years), and 24 were older (69 +/- 1 years). The degree of @entity644 at presentation was similar (4.5 +/- 0.7 vs 3.9 +/- 0.6 g/d, older vs younger, p = NS), but older @entity1 had higher @entity1011 levels (1.7 +/- 0.2 vs 1.2 +/- 0.07 mg/dl, p <.01), lower @entity1011 clearances (64 +/- 7 vs 111 +/- 7 ml/min., p <.05), and higher systolic blood pressure (164 +/- 8/88 +/- 2 vs 145 +/- 4/94 +/- 2 mm Hg, p <.01). Older @entity1 were more likely to decline a renal biopsy (21% vs 7.6%, p <.01). The most common final renal diagnoses were immunoglobulin A @entity8 (31%), @entity628 (24%), @entity101 (13%), and @entity8 (11%) in the younger @entity1 , and @entity8 (29%), @entity101 (25%), @entity2316 (17%), and @entity1987 (8%) in the older @entity1 . @entity230 were given to 17.7% of younger @entity1 and 16.7% of older @entity1 (p = NS). The percentage of @entity1 with improvement, defined as a 50% reduction in @entity644 with stable or improved renal function, was similar among older and younger @entity1 (33.3% vs 35.5%). However, older @entity1 were more likely to develop progression of @entity8 (33.3% vs 8.8%) and less likely to retain stable renal function (29.2% vs 53.3%). CONCLUSION: Significant differences exist in @entity8 between older and younger adults.
