The relationship between endogenous @entity172 , @entity443 , and XXXX in female residents of a rural Japanese community: the Taiji Study.

@entity172 @entity1 @entity604 @entity53 @entity79 @entity10684 @entity443
The aim of this study was to clarify the relationship between endogenous @entity172 , @entity443 ( @entity443 ), and @entity604 in pre-, peri-, and postmenopausal female residents of Taiji, a rural Japanese community. From a list of inhabitants aged 40 to 79 years, 200 @entity1 -50 @entity1 in each of four age decades-were randomly selected, and baseline @entity79 ( @entity79 ) at the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry in 1993. Total @entity53 (total E2) and @entity443 were measured, and @entity10684 ( @entity10684 ) was calculated using @entity443 and the percent @entity443 -unbound fraction ratio. @entity79 was measured again 3 years later, in 1996. @entity1 with ovariectomy or hysterectomy were excluded, and the remaining @entity1 were categorized into four groups: premenopausal ( n = 38), perimenopausal ( n = 14), postmenopausal group 1 (5 years or less since menopause; n = 18), and postmenopausal group 2 (6 years or more since menopause; n = 74). The mean value of total E2 was highest in the premenopausal group (49.1 pg/ml), followed by the perimenopausal group (26.4 pg/ml), and the postmenopausal groups (0.83 pg/ml in postmenopausal group 1 and 0.96 pg/ml in postmenopausal group 2). The means for @entity10684 showed the same pattern across the groups. After the multiple regression analysis of @entity79 at follow-up and endogenous @entity172 , in premenopausal @entity1 , there were no significant associations between @entity79 at follow-up and serum total E2 and @entity10684 . In perimenopausal women, however, serum total E2 and @entity10684 were significantly correlated with trochanteric @entity79 at follow-up ( P < 0.05); and in postmenopausal group 2, they were significantly correlated with lumbar spine and Ward's triangle @entity79 at follow-up ( P < 0.001 at lumbar spine, P < 0.05 at Ward's triangle). Concerning the association between @entity79 at follow-up and @entity443 , in the premenopausal group, serum levels of @entity443 were negatively correlated with @entity79 at the femoral neck ( P < 0.05). In regard to partial regression coefficients for the change rates of @entity79 over 3 years and serum @entity172 and @entity443 concentrations, in perimenopausal @entity1 , @entity10684 was correlated with the change rate of @entity79 at Ward's triangle ( P < 0.05), and in postmenopausal group 1, serum levels of @entity443 were significantly negatively related to change in @entity79 at the trochanter ( P < 0.01). No other relationships with change in @entity79 were observed at any sites. These findings suggest that serum E2, @entity10684 , and @entity443 levels differentially predict @entity79 levels in groups of differing menstrual status. It would, however, be difficult to predict @entity604 in middle-aged and elderly Japanese @entity1 over a 3-year period using these indices alone.
