Outcomes of the treatment of XXXX in a tertiary referral center.

@entity1 @entity135 @entity242 @entity5 @entity421 @entity2875
Head and @entity135 are a rare and heterogeneous group of @entity5 that pose management challenges. We report our experience with these @entity5 . Forty consecutive @entity1 treated for 44 @entity135 between 1997 and 2014 were culled from our prospectively maintained head and neck database. Five @entity1 were excluded. The adult cohort consisted 29 (83%) @entity1 of a mean age of 57.7   years, with 33 @entity242 . The most common diagnoses were undifferentiated @entity242 (27%) and @entity421 (21%). Clear surgical margins were achieved in 24/33 (73%) lesions. Twenty-two @entity1 received radiotherapy and/or chemotherapy. Fourteen @entity1 developed local (n   =   6), regional (n   =   1) and distant (n   =   7) recurrence. The overall 5-year survival was 66% with a mean survival interval of 66.5   months. Recurrent @entity242 , close (<1   mm) or involved surgical margins and advanced age were associated with statistically significantly reduced survival. The pediatric cohort consisted 6 (17%) @entity1 , with a mean age of 9   years. Five @entity1 had primary @entity2875 and one had @entity421 . Clear surgical margins were achieved in five (83%) @entity1 . All @entity1 received adjuvant radiotherapy and/or chemotherapy. Mean survival interval was 102   months. Three @entity1 developed local (n   =   1) or distant (n   =   2) recurrence. Twenty-three free and 8 pedicled flaps were performed in 25 @entity1 . Eleven out of thirty-nine (28%) lesions in 11 @entity1 developed a complication. In conclusion, @entity135 are best managed by a multidisciplinary team at a tertiary head and neck referral center and resection with clear margins is vital for disease control.
