Antibiotic prophylaxis in cerebrospinal fluid shunting: a prospective randomized trial in 152 hydrocephalic XXXX .

@entity1 @entity3256 @entity295 @entity114 @entity2929 @entity693 @entity281 @entity204 @entity298
The authors report a prospective, randomized 18-month study on the effect of prophylactic antibiotic treatment in 152 hydrocephalic @entity1 in whom clean shunt operations or revisions were done. The treated group received @entity3256 (totally 200 mg/kg) divided into six i.v. doses during 24 hours starting at the induction of anesthesia. @entity1 allergic to @entity114 received @entity2929 instead. Seventy-nine patients received antibiotics, and 73 (the control group) received none. All @entity1 were followed at least 6 months after operation or to their @entity204 . Eleven @entity1 developed signs of @entity281 , giving an overall @entity281 rate of 7.2%; however, the @entity281 occurred less than 1 month after the operation in only half of these. Six of the @entity1 had @entity295 , 4 had @entity298 , and 1 had @entity693 . In the treated group, the @entity281 rate was 8.9%; in the control group, the rate was 5.5%. There was no statistically significant difference. The prophylactic antibiotic regimen in this investigation did not reduce the @entity281 rate connected with cerebrospinal fluid shunting procedures.
