[Anatomopathological bases of latent ventricular dysfunction in insulin-dependent XXXX ].

@entity1 @entity82 @entity101 @entity6 @entity301 @entity13088 @entity1184 @entity3302 @entity453 @entity1002
INTRODUCTION AND OBJECTIVES: The natural history of @entity13088 remains unclear, mainly due to concurrent @entity301 or @entity101 . Since the presence of confounding factors is less likely in youngsters, they constitute a suitable study model to analyze early stages of @entity13088 . @entity1 AND METHODS: We screened 33 young normotensive asymptomatic @entity1 with @entity6 . Mean age was 28 +/- 8 y (range 18 to 46 y) and there were 14 @entity1 . RESULTS: 2-D Echo showed normal left ventricular size and wall motion in all @entity1 but one. Radionuclide basal ejection fraction was 56.5 +/- 6.6% and increased to 63 +/- 7.4% (p < 0.02) on exercise. According to Rozansky criteria, 16 @entity1 had an abnormal response. Abnormal stress sestamibi was detected in 18 @entity1 and only 3 had reversible defects. Coronary angiography was performed in 11 @entity1 with at least one abnormal non-invasive study response. Coronary angiography revealed normal vessels in all @entity1 and left anterior descending blood flow velocity (Doppler) increased 4 fold after @entity3302 infusion. Left ventricular biopsies showed @entity1184 (either nuclear or cellular) in 11, myocytolysis in 6, @entity82 in 9 and lipid deposits in 4. Morphometric analysis of cardiac samples comparing the @entity6 group and a control group showed that the volume fraction of @entity82 (0.19 +/- 0.06 vs 0.10 +/- 0.06; p < 0.01), fiber area -mu2- (1,062 +/- 547 vs 600 +/- 167; p < 0.02) and fiber diameter -mu- (24.2 +/- 3.3 vs 15.1 +/- 3.4; p < 0.001) were higher in the former; and volume fraction of the myocytes was higher in the latter (0.71 +/- 0.006 vs 0.89 +/- 0.07; p < 0.001). CONCLUSIONS: @entity1002 , not related to @entity453 , is frequent in asymptomatic young @entity6 @entity1 . Abnormal pathologic findings are common in the type of cell @entity1184 , @entity82 , myocytolysis and lipid deposits.
