Serum XXXX kinase release and alpha- and beta-adrenergic receptors.

@entity1169 @entity908 @entity7690 @entity1425 @entity3044 @entity35 @entity1063
Changes in the serum @entity908 kinase (CK) activity and the mechanism of its release after administration of two kinds of beta-blockers to @entity35 were studied in order to determine the mechanism of the increase in serum CK accompanying administration of beta-blockers. When @entity7690 or @entity1169 was administered at a dose of more than 10 mg/kg of body weight, the serum CK activity was increased in proportion to the dose. Also when an alpha-stimulator or an alpha, beta-stimulator such as @entity1063 and @entity1425 was administered, the serum CK activity was increased. When the beta-stimulator @entity3044 or the alpha 1-blocker prazosin was administered, there was no increase in the serum CK activity. In terms of consecutive administration of a combination of beta-blockers and @entity1425 , the serum CK activity was not increased by the second and succeeding administrations. As for the use of @entity1425 alone, on the other hand, the serum CK activity after the second administration was equal to that after the first administration. The increase in CK activity after administration of @entity1425 as the second treatment following administration of a beta-blocker as the first treatment was approximately the same as that after single administration of @entity1425 . From the fact that the serum CK activity in @entity35 was increased by administration of an alpha-stimulator and of a beta-blocker, it is possible that CK release in the blood is due to the action of alpha-receptors rather than beta-receptors. In the case of consecutive administration of a beta-blocker, the serum CK activity was not increased after the second administration. However, the serum CK activity was increased by the administration of an alpha-stimulator. This finding suggests the possibility that CK release is due to the disturbance of the balance between alpha-receptor and beta-receptor. Most of the CK isoenzymes released in the blood after administration of a beta-blocker were of the MM type.
