Susceptibility of anaerobic bacteria to XXXX and other beta-lactam antibiotics.

@entity2868 @entity2892 @entity3524 @entity12301 @entity2891 @entity3398 @entity3399
The in-vitro activity of @entity12301 was evaluated against 381 anaerobic clinical isolates and compared with that of @entity2892 , @entity3398 , @entity3399 ( @entity3399 ), @entity3524 and @entity2891 . Test isolates included strains with unknown resistance to the beta-lactam drugs, and two @entity2868 strains that could inactivate @entity3398 . @entity12301 and @entity2892 demonstrated superior activity against all the anaerobic bacteria tested, with MIC90s less than or equal to 1 mg/l. @entity12301 was generally one- to two-fold more active than @entity2892 . Resistance to both was demonstrated by the two Bact. fragilis strains that inactivated @entity3398 and by one strain of Fusobacterium; these three strains were also resistant to the other drugs studied. There were no other resistant strains to either @entity12301 or @entity2892 . @entity3524 and @entity2891 were the least active against the Bact. fragilis group, with resistance rates of 33 and 47%, respectively. Strains resistant to @entity3398 , latamoxef, @entity3524 and @entity2891 were found among some Clostridium spp. The Gram-positive cocci and Gram-positive bacilli were sensitive to all the drugs evaluated.
