Effect of XXXX on granulocyte and macrophage production.

@entity308 @entity19 @entity4558 @entity130 @entity7419
Using a model of uncomplicated @entity130 in @entity19 , we assayed the bone marrow and @entity4558 production of granulocytes and macrophages after @entity130 . The effects of burn size and burn wound excision and closure were studied. Using an in vitro quantitative clonal culture technique for granulocyte/macrophage progenitor cells (GM-CFC), myeloid precursors were directly assayed. Burns of a 10% body surface area were equal to burns of larger magnitude for effects on marrow and @entity4558 granulocyte/macrophage production. The total peripheral blood leukocyte and lymphocyte counts were @entity308 at days 1 and 4 postburn but were elevated at days 8 and 12. Granulocytes, however, remained significantly increased at days 8 and 12. The bone marrow response to burning showed an initial @entity308 in marrow cellularity on day 1 with return to normal values by days 8 and 12. The numbers of GM-CFC were significantly elevated on days 4-12 with a near threefold increase in the number of GM-CFC 12 days following @entity130 . The @entity4558 response to @entity130 was characterized by a decrease in the @entity4558 index on day 1 but then a persistent increase at days 8 and 12. Total @entity4558 cellularity was @entity308 on day 1 but significantly increased at days 8 and 12. The total number of @entity7419 was increased on days 4-12 with a 100-fold increase on day 8. The immediate or delayed excision of the burn wound did not alter marrow or @entity4558 response to burning. We conclude that following a @entity130 there is a marked alteration in the generation of the phagocytic cells of the granulocyte and macrophage series and that this response is secondary to the wounding process.
