Small intestinal function and structure in XXXX with @entity177 .

@entity1 @entity20583 @entity20538 @entity290 @entity31120 @entity177 @entity27713 @entity460 @entity34186 @entity6192
We studied 24 @entity1 with end-stage @entity177 not treated with hemodialysis ( @entity20583 ) and 16 @entity1 on regular hemodialysis ( @entity27713 ), to investigate the digestive, absorptive and morphological aspects of the small intestinal mucosa. Serum d-xylose test and biochemical parameters of absorption (serum @entity460 and proteins) were determined. Jejunal mucosal biopsies were obtained and tissue homogenates assayed for disaccharidases (sucrase, maltase and @entity290 ) and dipeptidases ( @entity20538 -glycinase, leucyl-glycinase and @entity34186 ). Histological changes were classified according to the severity of abnormality and compared with biopsies obtained from control subjects. Serum d-xylose test, @entity460 and proteins were normal in @entity1 with @entity6192 . Maltase specific activity was higher in @entity20583 than in controls (p less than 0.05). @entity290 and @entity34186 showed a tendency to decrease in @entity6192 , but this difference did not reach statistical significance. Sucrase, @entity20538 -glycinase and @entity31120 -glycinase specific activity in @entity6192 was similar to the control group. Histological changes of the small intestinal mucosa of mild to moderate degree were noted in 68% of @entity1 with @entity6192 vs 36% in control subjects (p less than 0.01). No significant difference was noted in the incidence of absorptive, enzymatic (with the exception of maltase) and histological changes between the two groups of @entity1 with @entity6192 . These changes are not influenced by hemodialysis, a long-term treatment averaging 6 months, they appear to represent primary manifestations of @entity6192 and may be related to the nutritional status of @entity1 with @entity6192 .
