XXXX : Is @entity12652 a Preventable Condition?

@entity1 @entity8820 @entity0 @entity242 @entity5 @entity12651 @entity12652 @entity4269 @entity4270 @entity3202 @entity3
BACKGROUND: @entity12652 is a rare complication of @entity0 treatment, representing a @entity12651 commonly associated with @entity4269 and severely impacting @entity1 's outcome. The @entity5 typically develops in the @entity3202 , pachydermatous, @entity8820 skin of limbs affected by long-standing @entity4269 . Clinical data associated with @entity12652 and @entity4269 management have rarely been published. METHODS AND RESULTS: In the period between 1980 and 2009, ten @entity1 with @entity12652 were diagnosed and treated at the Foeldiklinik, Hinterzarten, Germany. Nine of the ten @entity1 were female. Five @entity1 had previously suffered from @entity0 (and were treated with mastectomy); two from other @entity5 ; two @entity1 had @entity4269 , and one had undergone lower extremity lymphadenectomy. All @entity5 @entity1 had undergone radiation treatment. In all cases, the @entity242 developed in non-irradiated areas 6-48 years (average 16.3 years) after the onset of @entity4269 . None of the @entity1 had received @entity4270 ( @entity4270 ). Two @entity1 had above-elbow amputation, one had shoulder exarticulation, two @entity1 had wide excision and skin grafting, two @entity1 had above-knee amputation procedure, two @entity1 had a below-knee amputation procedure, and one @entity1 had no surgical treatment at all. The time to recurrence after surgery, time to @entity3 , @entity1 survival and @entity4270 were recorded. CONCLUSIONS: @entity1 with @entity4269 should be closely examined starting 5 years from the time of @entity4269 onset, paying special attention to those with associated @entity5 . Only early diagnosis and treatment by radical ablative surgery confers a reasonable prognosis with this rare but aggressive disease. A potential effect of @entity4270 on @entity12651 has to be studied in a greater @entity1 cohort.
