Prognostic significance of @entity1 tissue @entity7199 -related peptidases 11 and 15 in XXXX .

@entity1 @entity5 @entity563 @entity37598 @entity7199 @entity50834 @entity356
UNASSIGNED: @entity1 tissue @entity7199 -related peptidases (KLK) are a group of 15 @entity563 proteases which have been investigated as potential @entity5 biomarkers. This study determined the prognostic significance of @entity37598 and 15 expression levels in @entity356 specimens. Expression of @entity37598 and @entity50834 was assessed by immunohistochemistry staining on a tissue microarray constructed from 113 gastrectomy specimens from @entity1 with @entity356 . To minimize inter-observer variability, expression levels were quantified using an automated algorithm. Epithelial and stromal staining were assessed separately. Both @entity37598 and @entity50834 were expressed in @entity356 . There was no significant correlation between either @entity37598 or @entity50834 expression and the presence of lymph node metastases or Lauren classification (intestinal vs. diffuse). Higher levels of @entity37598 expression in @entity356 were associated with significantly worse overall survival (p   =   0.008), and a multivariate analysis showed that it had prognostic value independent of @entity5 stage and differentiation (p   =   0.004). Variations in @entity50834 expression were not significantly associated with prognosis. @entity37598 shows promise as a potential independent prognostic marker for @entity356 .
