Seroprevalence of 10 XXXX types in the general rural population of Anyang, China: a cross-sectional study.

@entity1 @entity1083 @entity33 @entity458 @entity1799 @entity1082
OBJECTIVES: Data on the seroprevalence of @entity1082 ) in China are limited. The objective of this study was to characterise the serological profiles of @entity1083 in a rural Chinese population and help establish effective vaccine policy. METHODS: Serum antibodies against the major capsid protein L1 of 10 HPV types (HPV-3, 6, 11, 16, 18, 45, 52, 57, 58 and 75) were evaluated with Luminex-based multiplex serology in a population-based study of 5548 adults (including 1587 couples) aged 25-65   years enrolled from rural Anyang, China, in 2007-2009. RESULTS: The seroprevalence for any HPV type and any of the types HPV-6/11/16/18 was 64.8% and 34.4%, respectively. 30.3% of adults were seropositive for any mucosal high-risk (HR) HPV, and HPV-58 (10.6%), @entity1799 (9.7%) and HPV-18 (9.3%) were the three most common types. 24.8% of seropositive individuals were @entity33 . Seroprevalence for most HPV types was similar among @entity1 and @entity1 . While mucosal low-risk HPV seropositivity was found to significantly decrease with age, the prevalence of antibodies to mucosal HR antigens showed a general trend of increase with age. The lifetime number of sex partners was independently associated with @entity33 . Positive correlation of spousal seropositivity was observed for mucosal HPV but not for cutaneous HPV. CONCLUSIONS: @entity1083 was common in both @entity1 and @entity1 in rural China. HPV seroprevalence differed significantly with age, @entity458 status. These findings will be useful for evaluating and establishing HPV vaccination programmes.
