Aortic pulse wave velocity index and mortality in XXXX .

@entity1 @entity122 @entity454
BACKGROUND: Aortic pulse wave velocity ( @entity122 ) is a strong independent predictor of overall and cardiovascular mortality in @entity1 with @entity454 ( @entity454 ). Nevertheless, because age, blood pressure, heart rate, and gender are strong determinants of both arterial stiffness and mortality, the individual relevance of @entity122 measurements remains controversial. METHODS: A cohort of 242 @entity1 with @entity454 undergoing hemodialysis was studied for a mean (+/- SD) duration of 78 +/- 46 months. At entry, together with standard clinical and biochemical analyses, @entity122 was measured using Doppler ultrasonography. On the basis of a nomogram established on 469 nonuremic subjects, a theoretical value of @entity122 was determined in @entity454 @entity1 according to their age, blood pressure, gender, and heart period. The @entity122 index (measured @entity122 - theoretical @entity122 ) was then calculated for each individual @entity454 @entity1 . RESULTS: Based on Cox analysis, the @entity122 index, but neither pulse pressure nor cardiac mass, was a strong and independent predictor of both cardiovascular and overall mortality, together with age and time on dialysis before inclusion. @entity1 with positive (versus negative) @entity122 index had a twofold adjusted risk of mortality during the follow-up. Per each 1 meter/second @entity122 index increment, we observed a 34% (crude) and a 14% (adjusted) increase in both cardiovascular and overall mortality (P < 0.02 for all). CONCLUSION: In @entity454 @entity1 , the calculation of a @entity122 index provides information about cardiovascular and overall mortality risk with high predictive power, showing that @entity122 measurements provide discriminatory prognostic power over and above conventional cardiovascular risk factors.
