Genetics and epidemiology of XXXX and symmetrical onychomadesis in the Gordon setter and the English setter.

@entity1375 @entity66 @entity235 @entity12730 @entity792 @entity4903 @entity12731
BACKGROUND: @entity1375 is one of the most common @entity4903 , whereas symmetrical onychomadesis is a rare claw disease in the general @entity235 population. The aims of this study were to estimate the prevalence of @entity1375 and symmetrical onychomadesis in a birth cohort of 291 Gordon setters at eight years of age. Further, to describe the age at diagnosis of @entity1375 in the 68 Gordon setters and 51 English setters included in the @entity12730 study. Finally, to elucidate potential associations between dog leukocyte antigen ( @entity12730 ) class II and @entity1375 and/or symmetrical onychomadesis in the Gordon setter and the English setter. RESULTS: In the birth cohort of eight years old Gordon setters, 2.7  % had @entity1375 and 8.9  % had symmetrical onychomadesis, but only one out of these 291 @entity235 (0.3  %) had both diseases. Mean age at diagnosis of @entity1375 for @entity235 included in the @entity12730 study was 6.4  years (95  % CI: 5.6-7.2  years) in the Gordon setters and 7.7  years (95  % CI: 7.2-8.2  years) in the English setters. The @entity12730 alleles most associated with @entity1375 in the Gordon setter and English setter were @entity12730 -DQB1*00201 (OR   =   3.6, 95  % CI: 2.1-6.4, p   <   0.001) and @entity12731 *00101 (OR   =   2.9, 95  % CI: 1.3-6.6, p   <   0.001), respectively. In the Gordon setter, the haplotype @entity12730 *01801/DQA1*00101/DQB1*00802 was significantly associated with both symmetrical onychomadesis (OR   =   2.9, 95  % CI: 1.7-5.2, p   <   0.001) and with protection against @entity1375 (OR   =   0.3, 95  % CI: 0.2-0.5, p   <   0.001). CONCLUSION: @entity1375 is a complex disease where @entity12730 genes together with other genes may be involved in the pathogenesis of the disease. In the Gordon setter, one @entity12730 haplotype that was associated with protection against @entity1375 was also associated with symmetrical onychomadesis. These findings indicate that closely linked genes, instead of or together with the @entity12730 genes themselves, may be associated with @entity1375 and symmetrical onychomadesis. In a breed where several @entity792 are prevalent all possible associations between @entity12730 genes and @entity66 need to be investigated before @entity12730 is considered used as a tool for marker-assisted selection.
