Exploring the anti- XXXX potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays.

@entity137 @entity6 @entity19 @entity5 @entity413
BACKGROUND: Plant-derived compounds have been used clinically to treat type 2 @entity6 for many years as they also exert additional beneficial effects on various other disorders. The aim of the present study was to investigate the possible mechanism of anti- @entity6 activity of twelve (seven Australian Aboriginal and five Indian Ayurvedic) plant extracts. METHODS: The ethanolic plant extracts were investigated for @entity413 uptake and adipogenesis in @entity19 3T3-L1 adipocytes. @entity137 studies were also carried out against two cancerous cell lines, HeLa and A549, to investigate the potential anti- @entity5 activities of the extracts. RESULTS: Of the seven Australian Aboriginal plant extracts tested, only Acacia kempeana and Santalum spicatum stimulated @entity413 uptake in adipocytes. Among the five Indian Ayurvedic plant extracts, only Curculigo orchioides enhanced @entity413 uptake. With respect to adipogenesis, the Australian plants Acacia tetragonophylla, Beyeria leshnaultii and Euphorbia drumondii and the Indian plants Pterocarpus marsupium, Andrographis paniculata and Curculigo orchioides reduced lipid accumulation in differentiated adipocytes. Extracts of Acacia kempeana and Acacia tetragonophylla showed potent and specific activity against HeLa cells. CONCLUSIONS: The findings suggest that the plant extracts exert their anti- @entity6 properties by different mechanisms, including the stimulation of @entity413 uptake in adipocytes, inhibition of adipogenesis or both. Apart from their anti- @entity6 activities, some of the extracts have potential for the development of chemotherapeutic agents for the treatment of @entity5 .
