Treatment results and prognostic factors of pediatric XXXX : a retrospective study.

@entity1 @entity41 @entity5 @entity521 @entity35166 @entity4180
BACKGROUND: We conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric @entity521 @entity1 . METHODS: This retrospective study was carried out analyzing the medical records of @entity1 with the pathological diagnosis of @entity521 seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to @entity1 with residual primary @entity5 was applied. Overall and event free survival ( @entity35166 and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in @entity35166 and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates. RESULTS: Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year @entity35166 and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, @entity4180 amplification, and high risk group. The majority of @entity1 (68%) presented in high risk group, where treatment outcome was poor, as only 21% of @entity1 survived for 3 year. CONCLUSION: Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to @entity1 with @entity41 evident after induction chemotherapy and surgery. Future attempts to improve @entity35166 in high risk group @entity1 with aggressive chemotherapy and bone marrow transplantation should be considered.
