A radiotherapy technique to limit dose to neural progenitor cell niches without compromising XXXX coverage.

@entity1 @entity137 @entity1313 @entity1161 @entity5 @entity19 @entity149 @entity11408
@entity1161 ( @entity1161 ) for @entity1313 is associated with @entity137 which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to @entity11408 without compromising @entity5 coverage. A study was performed in @entity19 to examine the rationale and another was conducted in @entity1 to determine its feasibility. C57BL/6 @entity19 received localized radiation using a dedicated animal irradiation system with on-board CT imaging with either: (1) Radiation which spared @entity11408 containing regions; (2) Radiation which did not spare these niches; or (3) Sham irradiation. @entity19 were sacrificed 24  h later and the brains were processed for immunohistochemical Ki-67 staining. For the @entity1 component of the study, 33 @entity1 with primary @entity1313 were evaluated. Two intensity modulated radiotherapy (IMRT) plans were retrospectively compared: a standard clinical plan and a plan which spares @entity11408 regions while maintaining the same dose coverage of the @entity5 . The change in radiation dose to the contralateral @entity11408 -containing regions was recorded. In the @entity19 model, non- @entity11408 -sparing radiation treatment resulted in a significant decrease in the number of Ki67(+) cells in dentate gyrus (DG) (P  =  0.008) and subventricular zone (SVZ) (P  =  0.005) compared to @entity11408 -sparing radiation treatment. In @entity11408 -sparing clinical plans, @entity11408 regions received significantly lower radiation dose with no clinically relevant changes in @entity5 coverage. This novel radiation technique should significantly reduce radiation doses to @entity11408 containing regions of the brain which may reduce @entity149 following @entity1161 for @entity1313 .
