Oral Exposure of @entity19 to XXXX Induces Hepatic Lipid Metabolism Disorder and Gut Microbiota Dysbiosis.

@entity1 @entity32 @entity99 @entity137 @entity19 @entity635 @entity777 @entity412 @entity8358 @entity9454 @entity165
@entity9454 ( @entity8358 ) has been considered as an endocrine disruptor that caused @entity1 @entity137 in different endpoints. Here, we revealed that oral administrations with @entity8358 at 100 and 500   mg/kg body weight for 28 days induced @entity99 which was characterized by significant increases of hepatic lipid accumulation and @entity412 (TG) levels in mice. The serum @entity165 (TC), high-density lipoprotein, and low-density lipoprotein levels also increased after @entity8358 exposure. Correspondingly, the relative mRNA levels of some key genes related to lipogenesis and TG synthesis increased significantly both in the liver and fat. Moreover, the increase in serum @entity635 and @entity777 levels by the treatment of @entity8358 indicated the occurring of @entity32 . Furthermore, the levels of bioaccumulation of @entity8358 in the liver and gut were very low as compared in the feces, indicating that most of @entity8358 stayed in gastrointestinal tract and interacted with gut microbiota until excreted. At phylum level, the amounts of the Bacteroidetes decreased significantly in the feces after 5 days @entity8358 exposure. High throughput sequencing of the 16S rRNA gene V3-V4 region revealed a significant reduction in richness and diversity of gut microbiota in the cecum of @entity8358 -treated @entity19 . UniFrac principal coordinates analysis observed a marked shift of the gut microbiota structure in @entity8358 -treated @entity19 away from that of the controls. More deeply, operational taxonomic units' analysis identified that a total of 361 gut microbes were significant changed. In @entity8358 -treated groups, the relative abundance of Firmicutes, Proteobacteria, and Actinobacteria increased and that of Bacteroidetes decreased. Our findings suggested that @entity8358 could lead @entity99 and gut microbiota dysbiosis in @entity19 .
