Prospective evaluation of the proportion of sessile serrated @entity652 / @entity1127 in endoscopically diagnosed XXXX with @entity5072 features.

@entity1 @entity124 @entity1127 @entity5072 @entity654 @entity14 @entity652 @entity1141
BACKGROUND AND STUDY AIMS: Sessile serrated @entity652 / @entity1127 (SSA/Ps) are considered precursors of @entity14 with @entity124 . However, it is still difficult to differentiate SSA/Ps from @entity1127 endoscopically; therefore, the prevalence of SSA/Ps remains uncertain in clinical practice. This study aimed to clarify the proportion of SSA/Ps in endoscopically diagnosed @entity1127 with @entity5072 features (E-HPs). @entity1 AND METHODS: @entity1 aged >= 40 years undergoing colonoscopy for standard clinical indications at our center were prospectively enrolled between June 2013 and May 2014. During colonoscopy, 0.05% @entity654 dye was sprayed throughout the colorectum to highlight lesions. All detected lesions were diagnosed by high definition magnifying narrow-band imaging and were resected endoscopically or surgically, apart from rectosigmoid E-HPs  <=5mm. The number of rectosigmoid E-HPs <=5mm was recorded, and some were resected for use as tissue samples. RESULTS: A total of 343 @entity1 (male: 42.9%; mean age: 61.5 years) were included. Among 3838 E-HPs (distal: 96.4%) detected in 294 @entity1 , 792 were resected and analyzed. All of 21 SSA/Ps identified in 17 @entity1 were included in E-HPs, and the overall proportion of SSA/Ps in E-HPs was 2.7%. However, this proportion increased with the size of E-HPs ( <=5 mm: 0.7%; 6-9 mm: 29.0%; >= 10 mm: 70%) and was higher in the proximal colon than in the distal colorectum (10.9% vs. 0.9%). In addition, no SSA/P was found in the rectum, and no SSA/P had cytological @entity1141 . CONCLUSIONS: The overall proportion of SSA/Ps in E-HPs was 2.7%, although this proportion was higher in the proximal colon and increased with the size of E-HPs. SSA/Ps were common in routine colonoscopy, with a prevalence of at least 5.0%. STUDY REGISTRATION: UMIN000010832.
