Efficacy of an Iranian herbal preparation (Lax-Asab) in treating functional XXXX : A randomized, placebo-controlled clinical trial.

@entity1 @entity1142
Functional @entity1142 is a common clinical complaint of @entity1 with unsatisfactory treatment outcome. We designed this study to evaluate the efficiency of a traditional herbal preparation (Lax-Asab) in treating chronic @entity1142 . In this double-blind, randomized, placebo-controlled clinical trial, @entity1 with chronic @entity1142 (n  =  48) were randomly selected to receive either the Lax-Asab powder (n  =  24) or placebo (n  =  24) on alternative days for 4 weeks. The Lax-Asab powder contains equal amounts of Cassia angustifolia Vahl. ( xi   y   f  n xi   y  ), Mentha piperita L. ( h   ji  o b   h  ), Zingiber officinale Rosc. ( sh  ng ji  ng), Glycyrrhiza glabra L. ( g  n c  o). A total of 40 @entity1 completed the study. We determined the severity of @entity1142 based on defecation frequency (per week) and defecation difficulties. Of the total of 48 @entity1 who participated, 40 completed the trial [24 @entity1 (60%), mean age, 21.0      4.2 years; 16 @entity1 (40%), mean age, 20.1      4.3 years]. The mean of weekly defecation frequency increased in both groups; from 1.8      0.41 to 4.8      1.12 times in @entity1 who received Lax-Asab and from 1.7      0.44 to 2.2      0.61 times in @entity1 who received placebo. A time-treatment interaction showed that this increase was significantly higher in the intervention group. Defecation difficulties improved significantly more in @entity1 who received Lax-Asab than @entity1 who received placebo. There was no statistically significant difference between the two groups with regard to the side effects observed. This study confirms the efficacy and tolerability of an Iranian herbal preparation, Lax-Asab, in treating @entity1 with chronic functional @entity1142 .
