[From cytogenetics to cytogenomics of adipose tissue @entity5 : 1. Benign adipose tissue XXXX ].

@entity5 @entity362 @entity44810 @entity359 @entity2008 @entity18391 @entity9625
@entity5 are characterized at the genetic level by different types of @entity2008 . A rearrangement of the @entity9625 ( @entity9625 ) gene, localized in 12q15 and coding for an architectural non-histone DNA protein, is observed in a majority of solitary superficial @entity362 . Alterations of @entity9625 are often resulting from reciprocal translocations, such as t(3;12)(q27-28;q15) that fuses LPP with @entity9625 , but a variety of @entity2008 , such as deletions, inversions or insertions are also observed. Rearrangements of chromosomal regions 6p21-22, 13q, 11q13, 12q13 or others are described in approximately one third of superficial @entity362 cases with abnormal karyotypes. The genes involved in these alterations remain to be determined. @entity18391 are pediatric neoplasms that are characterized by rearrangements of @entity44810 , located in 8q11-12 whereas @entity362 , that resemble brown fat, are associated with 11q13 rearrangements together with often complex chromosomal alterations. Deletions of 13q and 16q have been identified in spindle cell @entity362 . A t(11;16)(q13;p12-13) have been described in the two published karyotypes of @entity362 . The chromosomal features of other rare benign @entity5 , the differential diagnosis of which is occasionally difficult, such as @entity362 , @entity362 , or @entity359 , myolipomas, myxolipomas are still poorly defined. Although the genetic characterization of benign @entity5 has been dramatically in progress over the last ten years, many aspects remain obscure and warrant future investigations for a better comprehension of underlying molecular mechanisms.
