[Clinical characteristics and prognosis of XXXX @entity1 with extremely elevated carcinoembryonic antigen level].

@entity1 @entity5 @entity1442 @entity10580 @entity3 @entity694
OBJECTIVE: To explore the clinicopathological characteristics and prognosis of @entity694 @entity1 with extremely elevated serum carcinoembryonic antigen( @entity10580 ) level before operation(>50  g/L). METHODS: Clinicopathological and follow-up data of 1250 @entity1 with @entity694 undergoing @entity5 resection between January 2001 and December 2011 were retrospectively analyzed. All the @entity1 were divided into three groups according to the preoperative serum @entity10580 levels as normal group (0-5  g/L, 721 cases), elevated group(5-50  g/L, 408 cases) and extremely elevated(>50  g/L, 121 cases). Kaplan-Meier method was used to analyze the overall survival and disease-free survival. Log-rank test was used to compare the survival between groups. Cox regression was used to screen the independent prognostic factors of @entity694 . RESULTS: Compared with normal and elevated groups, @entity1 with extremely elevated @entity10580 had more @entity1442 ,N,M stages (P<0.01), more palliative surgery (P<0.01) and more lymphovascular invasion(P<0.01). During the follow-up, @entity1 with extremely elevated @entity10580 demonstrated significantly higher ratio of distant @entity3 and liver @entity3 (both P=0.001). After radical surgery, 5-year overall survival rate of @entity1 with normal, elevated and extremely elevated @entity10580 levels was 70.1%, 54.4% and 42%, respectively, with statistically significant difference among three groups (P<0.001). Multivariate analysis showed that @entity5 differentiation, TNM staging, preoperative @entity10580 levels, lymphovascular invasion and adjuvant chemotherapy were independent prognostic factors for @entity694 (all P<0.01). CONCLUSIONS: @entity694 @entity1 with extremely elevated preoperative @entity10580 levels are associated with more unfavorable pathological factors, advanced TNM stage and more distant @entity3 (especially the liver @entity3 ) during the follow-up. The elevated degree of preoperative @entity10580 level is an independent poor prognostic factor of @entity1 with @entity694 .
