Small airways disease in XXXX without chronic air-flow limitation.

@entity1 @entity32 @entity1568 @entity82 @entity5924 @entity1576
We measured airway diameter and quantitated airway pathology scores in @entity1576 ( @entity1576 ) and @entity5924 ( @entity5924 ) in 37 @entity1 undergoing resection for solitary pulmonary nodules. The @entity1 had FEV1 greater than 75% of the predicted. Measurements of FEV1, @entity1568 washout curve (delta N2/L), closing volume as a percentage of vital capacity (CV/VC%), and maximal flow at 50% of VC (V50) were made prior to surgery. There were 22 smokers and 15 nonsmokers. There were more @entity5924 per cm2 of tissue than @entity1576 (0.74 versus 1.02). The mean internal diameter for @entity5924 was 0.55 +/- 0.27 mm; for @entity1576 it was 0.47 +/- 0.15 mm. There were more @entity5924 greater than 1.0 mm in internal diameter than @entity1576 greater than 1.0 mm, and the mean diameter of @entity5924 was less than that noted in autopsy specimens. The total pathology scores for all airways were less than those found in Caucasian populations. Pathology scores were higher for @entity5924 than for @entity1576 , except for pigment deposition. @entity32 scores were higher in @entity1 with FEV1 less than 100% predicted both for @entity1576 (p less than 0.05) and for @entity5924 (p less than 0.05). FEV1 values correlated with goblet cell metaplasia scores (p less than 0.05) for @entity5924 and with @entity82 (p less than 0.05), pigment deposition (p less than 0.05), and intraluminal macrophages (p less than 0.05) for @entity1576 . Tests specific for small airways (delta N2/L, V50, CV/VC%) did not correlate with the pathology scores.
