Electrophysiological and behavioral assessments of dopamine autoreceptor activation to @entity3826 in XXXX .

@entity7875 @entity25165 @entity3826 @entity1767 @entity35 @entity22292
Single neuronal activity was recorded extracellularly in the substantia nigra pars compacta (SNC) in @entity35 anesthetized with @entity22292 . @entity1767 in a dose of 10 micrograms/kg had no significant effects on the SNC neurons. @entity25165 (cumulative i.v. dose of 40 micrograms/kg, given as: 5, 5, 10 and 20 micrograms/kg) inhibited the firing rate of dopaminergic neurons, in a dose-dependent manner. @entity1767 (cumulative i.v. dose of 10 micrograms/kg, as: 2.5, 2.5 and 5 micrograms/kg) reversed the effect of @entity3826 . Complete reversal of the firing rate to @entity1767 was observed with a dose of 10 micrograms/kg. In @entity35 pretreated with 10 micrograms/kg of @entity1767 , there was a dramatic shift to the right of the @entity3826 dose-response curve (cumulative i.v. dose of 800 micrograms/kg, as: 50, 50, 100, 200 and 400 micrograms/kg), and this inhibition was reversed by @entity1767 (cumulative i.v. dose of 400 micrograms/kg, as: 50, 50, 100 and 200 micrograms/kg). @entity3826 in doses of 40 micrograms/kg and 800 micrograms/kg elicited @entity7875 behavior and stereotypy, respectively. @entity3826 in a dose of 800 micrograms/kg elicited stereotypy in @entity35 treated 3 min before with 10 micrograms/kg of @entity1767 . Therefore, electrophysiological determinations of events in the SNC dopaminergic neurons are given support by the behavior observed in these @entity35 .
