Association of chemokine and @entity436 expression with the invasion and XXXX .

@entity1 @entity71698 @entity3024 @entity5 @entity9350 @entity71699 @entity2 @entity1570 @entity7415 @entity3 @entity11274 @entity687 @entity7416 @entity420 @entity436
UNASSIGNED: The chemokine system has been reported to be utilized and manipulated by @entity5 cells in order to promote @entity5 growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in @entity2 tissues. @entity5 and healthy normal tissue samples were obtained from 120 @entity2 @entity1 following surgical resection. Immunohistochemistry and reverse transcription quantitative polymerase chain reaction were used in order to identify the protein and messenger (m)RNA expression of chemokines, including chemokine (C-X-C motif) ligand (CXCL)12/stromal cell-derived factor (SDF)-1, @entity687 , chemokine ( @entity11274 and @entity3024 , and the corresponding chemokine receptors, chemokine ( @entity436 , @entity7415 , @entity7416 and chemokine ( @entity9350 , respectively. The results revealed that compared with the normal lung tissues, @entity2 tissues expressed significantly higher mRNA levels of @entity1570 / @entity1570 , @entity436 , @entity687 / @entity687 , @entity7416 , @entity11274 and @entity9350 (P<0.01). In four histological subtypes, @entity420 presented dominant expression of @entity436 , @entity7416 , @entity687 / @entity687 and @entity11274 (P<0.05). In addition, it was demonstrated that @entity5 staging was inversely correlated with @entity436 @entity9350 and @entity7416 mRNA expression as well as positively correlated with @entity1570 / @entity1570 , @entity687 / @entity687 and @entity11274 mRNA levels (P<0.05). Lymph node @entity3 presented a positive correlation with @entity436 , @entity7416 and @entity687 / @entity687 expression and a negative correlation with @entity11274 and @entity9350 expression (P<0.05). Furthermore, vascular invasion was more prevalent in @entity1 with higher expression levels of @entity436 , @entity9350 or @entity11274 (P<0.01). In conclusion, these data suggested that the ligand-receptor interaction of @entity71698 , @entity1570 - @entity436 and @entity71699 may be involved in the tumorigenesis of @entity2 . Higher expression levels of chemokines and lower expression of chemokine receptors indicated poor @entity5 staging. The CXC chemokine receptors, @entity436 and @entity7416 , promoted lymphatic @entity3 through the activation of their specific ligands, while @entity11274 and its receptor @entity9350 had an essential role in hematogenous @entity2 .
