Successful treatment with combined chemotherapy of two adult cases of XXXX in recipients of umbilical cord blood cell transplantation.

@entity1 @entity8 @entity9058 @entity2879 @entity1583 @entity1891 @entity617
@entity9058 ( @entity9058 ), which occurs during the early period following allogeneic hematopoietic stem cell transplantation (HSCT), is often difficult to diagnose. It is characterized by severe clinical manifestations and high mortality. Despite current therapeutic approaches, outcomes remain poor. Here, we summarize the cases of two @entity1 who experienced engraftment failure and subsequently developed @entity8 ( @entity8 ). Both @entity1 had high-risk @entity1583 for which they underwent umbilical cord blood transplantation (UCBT) at our institution. Based on the presence of massive hemophagocytosis in their bone marrow specimens and the results of chimerism analysis, diagnosis of @entity8 was made in both cases. A single infusion of low-dose @entity2879 was administered immediately to each @entity1 . Four days after the injection, therapeutic efficacy was evaluated. As both cases showed an insufficient response to @entity2879 , we added @entity1891 and a medium dose of @entity617 . Clinical symptoms rapidly improved and stable engraftments were observed within a week. The first and second @entity1 were alive 1008 and 232  days after UCBT, respectively. The combined use of low-dose @entity2879 and @entity1891 plus @entity617 appears to be a promising treatment option for @entity8 , without serious adverse side effects.
