[ XXXX induces differentiation of @entity1 @entity189 in BALB/C @entity19 xenograft model].

@entity1 @entity4447 @entity9188 @entity5 @entity19 @entity957 @entity189 @entity4698 @entity1778
BACKGROUND _ OBJECTIVE: There is evidence that @entity4447 ( @entity9188 ) induce differentiation of @entity1778 cells; however, little is known about its effect on solid @entity5 . The aim of this study was to investigate whether @entity9188 can induce cell differentiation and its association with growth inhibition in @entity1 @entity189 using BALB/C @entity19 xenograft model. METHODS: Poorly differentiated @entity1 @entity957 cells from CSNE-1 cell strain were transplanted subcutaneously to BALB/C @entity19 to produce @entity5 . @entity9188 at a dose of 5 mg.(kg.d)-1 was given intraperitoneally for 10 consecutive days, and then 3 times a week for the following 3 weeks. The xenograft @entity5 growth in @entity19 was observed after drug administration. The morphological changes of the @entity5 were examined under light and electron microscopy. @entity4698 ( @entity4698 ) expression was determined by immunohistochemistry. RESULTS: @entity9188 at dose of 5 mg.(kg.d)-1 significantly inhibited the @entity5 growth in vivo, with a inhibitory rate of 75.4%. Remarkable cell differentiation induced by @entity9188 was observed under light microscope and transmission electron microscope, which was characterized by keratinization of @entity5 cells, decreased nuclear/cytoplasm ratio, increased cytoplasmic organelles and rich tonofibrils in cytoplasm. Desmosomes and micro-processes were much more frequently observed in @entity5 treated with @entity9188 . Significantly decreased @entity4698 expression was observed in @entity9188 -treated @entity5 cells. The @entity4698 -positive cell index (PI) was 53.6 +/- 7.0% in @entity9188 -treated @entity19 , and 95.2 +/- 5.0% in control, respectively (P < 0.001). CONCLUSION: The growth of @entity1 @entity189 xenograft in BALB/C @entity19 can be significantly inhibited by @entity9188 , which might be related to the cell differentiation induced by @entity9188 .
