Gonadotrophin-independent precocious puberty associated with later diagnosis of XXXX .

@entity1 @entity251 @entity5 @entity189 @entity4418 @entity342 @entity13558
BACKGROUND: @entity5 are very rare in @entity1 . @entity5 ( @entity5 ) account for the majority of @entity5 in young @entity1 , and @entity189 are a common component of @entity5 in adolescents. CASE PRESENTATION: A 9.8-year-old @entity1 presented with the development of pubic and facial hair over a period of 2 years. He had a growth spurt and examination revealed pubertal staging of G4 P4 A2 with a 6-mls testis on the right and a 4-mls testis on the left. Investigations revealed suppressed gonadotrophins, a @entity251 concentration of 10.3 nmol/l and normal @entity4418 and adrenal @entity342 levels. Tumour markers were negative. Following treatment with @entity13558 , his height velocity slowed down. At the age of 13.7 years, his treatment was stopped. At the age of 14.8 years, he presented with a grossly enlarged right testis and elevated beta @entity1 chorionic gonadotrophin (>1,400 IU/l). He underwent right orchidectomy and histology revealed an @entity189 with no vascular invasion. Analysis of luteinizing hormone/choriogonadotrophin receptor revealed no mutation. CONCLUSION: We present a case of @entity189 in a @entity1 who had presented 5 years before with features suggestive of gonadotrophin-independent precocious puberty.    2014 S. Karger AG, Basel.
