Radiation-induced @entity296 in the XXXX .

@entity82 @entity712 @entity296 @entity235 @entity4 @entity17157 @entity528
Sequential necropsies and histologic evaluations of young adult @entity235 were performed after irradiation of the thorax. Total doses to the heart were 36, 44, or 52 Gy given in 4-Gy fractions in 4 weeks. One month after irradiation there was little histologic evidence of damage visible by light microscopy. However, ventricular and septal weights were increased, probably due to @entity4 . At 3 months damage to endothelial and mesothelial cells was evident. By 12 months the myocardium was thinned and @entity528 and loss of muscle cells and Purkinje fibers were observed. There was extensive @entity82 as well as intimal proliferation in coronary arteries. Morphometric analyses were performed on the myocardium, pericardium, atria, and aorta. There was a slight increase in perivascular connective tissue in the myocardium. The pericardium was increased in thickness and the ratio of smooth muscle to @entity17157 was decreased in the aorta. Severe @entity82 occurred only in the right atrium. At 1 year there was no clinical evidence of @entity712 ; however, evidence of @entity296 was present histologically and functionally. Additional stress and continued aging are likely to enhance the damage and lead to serious complications. The interactions of irradiated lung and heart require further investigation.
