Two-hour @entity36419 inhalation exposure and 91-day recovery: a preliminary description of pathologic changes in F344 XXXX .

@entity1 @entity32 @entity825 @entity82 @entity35 @entity548 @entity4838 @entity36419
The accidental release of @entity36419 (MIC) in Bhopal, India, was reportedly responsible for the deaths of more than 2,000 @entity1 . To study the pathology of acute inhalation exposure to MIC, the tissues of male and female Fischer 344 @entity35 were evaluated immediately after a single 2-hr exposure to 0, 3, 10, or 30 ppm MIC, and through day 91. Early gross pathologic changes in the 30 ppm-exposed @entity35 included a reddish white encrustation around the mouth and nose, a small thymus, and distension of the gastrointestinal tract with gas. Lungs (middle and median lobes) showed consolidation and @entity548 and failed to deflate when the chest cavity was opened. Microscopic changes in the upper respiratory tract 3 hr after exposure included marked @entity4838 and respiratory epithelia from the basement membrane with accumulation of serofibrinous fluid. On day 1, acute @entity32 and fibrinopurulent exudate partially blocked the nasal passages. Epithelial cells had sloughed from the nasopharynx, @entity825 , bronchi, and major bronchioles, leaving the basement membrane covered with fibrin and exudate. @entity32 and intraluminal @entity82 of the airways were observed by day 3, with increased intraluminal @entity82 by day 7. Lower airways became blocked by exfoliated cells, mucous plugs, and/or intraluminal @entity82 .(ABSTRACT TRUNCATED AT 250 WORDS)
