Renin-angiotensin system (RAS) blockade attenuates growth and metastatic potential of @entity1358 in XXXX .

@entity5 @entity19 @entity3371 @entity9886 @entity1358 @entity22416 @entity703
OBJECTIVES: @entity1358 ( @entity1358 ) is the most frequent type of @entity5 among @entity703 in adults and responds poorly to radiotherapy and chemotherapy. There is evidence that blockade of the renin-angiotensin system (RAS) might have antineoplastic effects. The aim of this study was to investigate the effects of RAS blockade on @entity1358 in a @entity19 model. METHODS AND MATERIALS: @entity19 @entity703 cells (Renca) were injected (1*10(5)) into the subcapsular space of the left kidney of BALB/c @entity19 (8wk of age). The animals were divided into 4 groups: a control group (no treatment), angiotensin-receptor blockers group ( @entity9886 100mg/kg/d), angiotensin-converting enzyme inhibitor group ( @entity3371 10mg/kg/d), and angiotensin-receptor blockers +angiotensin-converting enzyme inhibitor group ( @entity9886 100mg/kg/d + @entity3371 10mg/kg/d). The animals received the drugs by gavage for 21 days after inoculation, beginning 2 days before @entity5 induction, and were then euthanized. After killing the animals, the kidneys and lungs were removed, weighed, and processed for histopathological and immunohistochemical analyses. Angiogenesis and vascular microvessels were assessed with the antibodies anti-vascular endothelial growth factor and anti- @entity22416 . RESULTS: Angiotensin II-inoculated animals developed @entity703 . Treated animals presented @entity5 , regardless of the therapeutic regimen, and far fewer lung metastases in both quantity and dimension compared with the controls. The expression of vascular endothelial growth factor and @entity22416 were significantly decreased in @entity703 of treated animals compared with the controls. CONCLUSIONS: Our findings suggest that blockade of RAS decreases @entity5 proliferation and metastatic capacity of @entity1358 in this experimental model.
