Delayed immune-mediated adverse effects related to XXXX dermal fillers: clinical findings, management, and follow-up.

@entity1 @entity854 @entity2975
BACKGROUND: It has been thought that @entity2975 (PA) injections do not have inflammatory side effects. Recent evidence shows that local and regional delayed adverse effects may appear with its use. OBJECTIVE: To evaluate the clinical complaints and follow-up of @entity1 with delayed immune-mediated adverse effects related to PA injections. METHODS: Prospective, case-series study of 10 @entity1 with delayed adverse effects related to PA injections. Only @entity1 with intermediate or delayed adverse effects related to @entity2975 injection were included. @entity1 with immediate side effects were excluded. @entity1 underwent clinical management, follow-up, and when possible, blood tests and biopsy. RESULTS: Average latency period to onset of symptoms was 10 months (range 2-36). Tender, inflammatory nodules--granulomas--with pseudo-abscesses were commonly seen. @entity854 were found in all analyzed cases. After 20.1 months average follow-up, five @entity1 were in remission, two had recurrent bouts, and three were lost to follow-up, one of them in remission. CONCLUSION: Although it happens infrequently, local and regional delayed and recurrent granulomatous reactions may complicate PA gel injections.
