Brief Report: Miscarriages in Female @entity309 XXXX : Associations With Serologic Findings, Disease Activity, and Antirheumatic Drug Treatment.

@entity1 @entity2208 @entity6822 @entity33934 @entity1499 @entity309
OBJECTIVE: To study the association between @entity2208 in @entity309 ( @entity309 ) @entity1 and serologic findings, disease activity, and antirheumatic drug treatment, and to study disease activity and reproductive outcomes after a @entity2208 . METHODS: Within a nationwide prospective cohort study (Pregnancy-Induced Amelioration of @entity309 study), @entity1 with @entity309 were followed up from preconception until 6 months after delivery or @entity2208 . Univariate and logistic regression analyses were performed to assess variables of interest, with covariates included in the models if the P value for association with @entity2208 was <0.20 and subsequently excluded if the P value was >0.10. RESULTS: Among 162 pregnancies, 28 @entity2208 occurred (17.3%; 95% confidence interval 12.2-24.0%). @entity1 who miscarried were older than @entity1 with an ongoing pregnancy. @entity1 who miscarried tended to be more often positive for anti-citrullinated protein antibodies (ACPAs), to have higher disease activity scores, and to have more often received @entity1499 ( @entity6822 ) therapy in the past. Logistic regression showed a tendency toward a higher likelihood of @entity2208 in association with increasing age (P   =   0.065) and presence of ACPAs (P   =   0.092). After @entity2208 , 33% of @entity1 had a flare of @entity309 . Within 1 year, 68% of @entity1 became pregnant again, 14% stopped trying to conceive, and 11% were lost to followup. The live birth rate of the subsequent pregnancy was 90%. CONCLUSION: The @entity2208 rate in the @entity33934 cohort is comparable to that in the general population. Due to the low frequency of @entity2208 in this study, the associations between @entity2208 in @entity309 and the presence of ACPAs, disease activity, and @entity6822 use did not reach statistical significance. Within 1 year after @entity2208 , the majority of @entity1 who continued trying to conceive achieved a pregnancy resulting in a live birth.
