XXXX of low malignant potential: a clinicopathologic study of 30 cases with comparison to well-differentiated @entity4348 .

@entity43 @entity1 @entity5 @entity189 @entity3 @entity4348
Thirty cases of @entity43 of low malignant potential (ETLMP) were studied and compared with 32 cases of well-differentiated @entity4348 . ETLMP was distinguished from well-differentiated @entity4348 by the absence of destructive stromal invasion, glandular confluence, or stromal disappearance. @entity189 in a low malignant potential @entity5 was defined as areas showing grade 3 nuclei, sometimes associated with an intracystic villoglandular or cribriform pattern. Microinvasion in an ETLMP was defined as one or more areas of invasion with an area of < or =10 mm2. Because a cribriform pattern may be seen in purely intraglandular proliferations, the latter was not taken as evidence of invasion. The @entity1 with ETLMP ranged from 28 to 86 years of age (mean 54.9 years), and only one @entity1 (3%) had other than stage I disease at presentation. The @entity1 with well-differentiated @entity4348 ranged from 26 to 87 years of age (mean 51.1 years), and three @entity1 (9%) had stage II disease at presentation. An adenofibromatous pattern was present in 47% of cases of ETLMP and squamous differentiation in 47%; @entity189 occurred in 7% of cases and stromal microinvasion in 7%. None of these findings appeared to influence the prognosis because all @entity1 with ETLMP were free of recurrent disease or @entity3 on follow-up, whereas 20% of @entity1 with well-differentiated @entity4348 followed for >6 months developed recurrent disease. Thus, the prognosis of ETLMP, when defined by the above criteria, is favorable and is superior to that of well-differentiated @entity4348 .
