@entity1050 ( XXXX of the cerebellum). Report of two cases.

@entity1 @entity154 @entity1184 @entity245 @entity4494 @entity1050 @entity10389 @entity76 @entity302 @entity4651 @entity694
Two cases of @entity1050 or @entity1184 of the cerebellum are presented. This brings the total number of such cases reported in the literature to 42. Pathologically the disease is characterized by a circumscribed @entity76 consisting of thickening of the cortex with closely packed @entity4494 cells in the granular layer and with large myelinated axons in the molecular layer. Purkinje cells are missing and the central white matter is greatly reduced. The first @entity1 , a @entity1 39 years of age, had in association to the @entity76 , a @entity10389 brain (2320 g). He had suffered from @entity302 since he was 24-years-old and died with metastasizing @entity694 . An electron microscopic study of the @entity76 disclosed perikarya containing large amounts of rough endoplasmic reticulum, cell processes filled with coated and dense core vesicles. In addition, there were numerous enlarged myelinated axons in the molecular layer. The second @entity1 , a @entity1 74 years of age, had a small area of @entity1184 of the left cerebellar hemisphere measuring one centimeter in diameter. Specific symptoms were very scant in the first case and absent in the second one indicating a very slow evolution - if any - of the disease process. The etiology and pathogenesis remain unknown. However, the organoid structure of the lesion, the frequent association of @entity4651 and other @entity154 , and the occurrence of familiar cases would favor the disease being basically a @entity245 .
