External validation of the paediatric risk of XXXX index.

@entity5 @entity1
OBJECTIVE: This study aimed to validate the paediatric risk of @entity5 index (PRMI), as previously published. DESIGN: External validation study. SETTING: Academic hospital: Radboud University Medical Center. POPULATION: Female paediatric @entity1 under the age of 18  years diagnosed with, or treated for, an adnexal mass between January 1999 and October 2013. METHODS: Information was collected on diagnosis, presenting symptoms, and signs and imaging characteristics. The PRMI was calculated for each @entity1 . Sensitivity, specificity, and positive and negative predictive values were calculated, and the results were visualised using a receiver operating characteristic curve (ROC curve). MAIN OUTCOME MEASURES: Histological diagnosis, discriminative performance using the area under the curve (AUC) of the  ROC curve and sensitivity and specificity. RESULTS: Seventy-eight @entity1 were included, with a median age of 12  years. A malignant mass was found in 17 @entity1 (21.8%). The PRMI with a cut-off value of 7 resulted in a sensitivity of 70.1% (95% CI 44.1-89.6%) and a specificity of 85.3% (95% CI 73.8-93.0%). The area under the ROC curve was 0.868 (95% CI 0.756-0.980). CONCLUSIONS: The PRMI showed less discriminative capacity than  originally published, but its performance was still good; however, further prospective validation studies are needed to  define whether the model is useful in daily clinical practice.
