Functional heterogeneity of the kupffer cell population is involved in the mechanism of @entity2545 in XXXX administered endotoxin.

@entity5694 @entity568 @entity1505 @entity2545 @entity21953 @entity881 @entity35 @entity224
BACKGROUND: The purpose of this study was to determine if evidence of functional heterogeneity between subtypes of the Kupffer cell (KC) may be involved in the mechanism of the protective effect of @entity2545 ( @entity21953 ) in @entity5694 . METHODS: @entity35 pretreated with or without @entity21953 were administered lipopolysaccharide (LPS) or vehicle. Serum and liver tissues were collected after LPS administration for cytokine measurements and pathological and immunohistochemical evaluation. RESULTS: After LPS administration, increases in expression of @entity1505 and @entity568 mRNA in the liver were blunted significantly by @entity21953 . In control liver tissue, ED2-positive cells were a predominant fraction, with a few ED1-positive cells, and @entity21953 eliminated only ED2-positive cells. Further, ED2-positive cells were larger in size than ED1-positive ones. Importantly, the number of ED1-positive cells in the liver was increased about threefold in the control group but not in the @entity21953 group after LPS injection. Intermediate or large KCs isolated by counterflow centrifugal elutriation showed greater capacity for phagocytosis and production of @entity224 and @entity1505 than small ones. In contrast, @entity568 production was increased to a greater extent in small than in intermediate or large cells. @entity21953 eliminated the intermediate or large KC subpopulation predominantly. CONCLUSION: Collectively, functional heterogeneity of the KC population was involved in the mechanism of the protective effects of @entity21953 in @entity5694 . @entity1505 derived from activated intermediate or large KCs may activate small KCs and the latter may be recruited to other organs, such as lungs and kidneys, and produce a large amount of @entity568 , leading to @entity881 .
