Peroxisome proliferator-activated receptor-gamma agonist induces regulatory T cells in a XXXX model of @entity2023 .

@entity32 @entity3229 @entity59 @entity2023 @entity19986 @entity19 @entity12098 @entity4301 @entity3744 @entity19985
OBJECTIVE: To evaluate the effects of @entity3229 ( @entity3229 )-y agonist on the induction of regulatory T cells (Tregs) in a @entity19 model of @entity2023 . STUDY DESIGN: Randomized controlled trial. SETTING: Animal study. SUBJECTS AND METHODS: BALB/c @entity19 that received ovalbumin sensitization and challenge served as the ovalbumin group (n = 6). Two separate groups of 6 @entity19 received intragastric administration with @entity3229 -y agonist @entity12098 (30 mg/kg/d) or @entity12098 plus @entity3229 -y antagonist @entity4301 (0.5 mg/d) before each ovalbumin challenge. The control group (n = 6) was treated with drug vehicle alone. Various allergic responses were assessed. Real-time polymerase chain reaction was performed to investigate the mRNA expression of @entity3744 ( @entity3744 ), @entity19985 , and @entity19986 . Flow cytometry was used to determine the percentage of Tregs. RESULTS: @entity19 developed typical pathophysiological @entity2023 features after the ovalbumin challenge. The frequencies of sneezing and scratching were significantly decreased by @entity12098 treatment (P < .0001). Eosinophils infiltration and the levels of @entity59 and interferon-y in nasal cavity lavage fluid and sera immunoglobulin E were also markedly decreased by @entity12098 (P < .001). The expression of @entity3744 mRNA and the population of Tregs were significantly increased by @entity12098 (P < .05). Cotreatment with @entity4301 reversed the anti-inflammatory effects of @entity12098 . The effects of @entity3229 -y agonist on @entity3744 mRNA expression and Tregs induction were abrogated by administration of @entity4301 . CONCLUSION: @entity3229 -y agonist attenuates upper @entity32 in a @entity3229 -y-dependent fashion, and the beneficial effects of @entity12098 in @entity32 may be mediated by induction of Tregs.
