Antimicrobial Activity of a Novel Vascular Access Film Dressing Containing XXXX .

@entity1216 @entity5164 @entity5132 @entity2636 @entity5165
BACKGROUND: Covering insertion sites with @entity1216 impregnated dressings has been proven to be clinically effective in reducing catheter related blood stream infections (CR-BSI). Two @entity5164 ( @entity5165 )-impregnated dressings are commercially available, a @entity2636 foam disk and a film dressing containing a @entity5164 -impregnated gel pad. While both have demonstrated efficacy in clinical settings, the major drawback of high cost and impaired IV insertion site visibility limits their usage. A new, simple film dressing containing @entity5165 within its adhesive layer is now available. The objective of this study was to test the in vitro antimicrobial efficacy of the new dressing in comparison to the @entity5165 -impregnated gel dressing. METHODS: Quantitative aliquots of suspensions (concentration of 1.0x106 to 5.0x106 cfu/sample) of clinically relevant challenge organisms (Staphylococcus species, gram-negative bacilli, @entity5132 ) were incubated in contact with the new @entity5165 -containing film dressing, a placebo version of the same (negative control) and the commercially available @entity5165 -impregnated gel dressing (positive control). Serial dilutions of the surviving organisms were quantified using the pour plate after 1, 3, 5, and 7 days of incubation in order to calculate an antimicrobial log10 reduction for each organism/dressing combination at each point in time. RESULTS: The new @entity5165 -containing film dressing delivered greater than 5.0 log10 reduction throughout the 7 days on all aerobic gram-negative bacilli and Staphylococcus species tested. As of day 1 the @entity5165 -containing film dressing provided greater than 5.0 log10 reduction on @entity5132 . There were no statistically significant differences in the log10 reduction between the two dressings tested. CONCLUSION: The new @entity5165 -containing film dressing was found to be as effective as the @entity5164 -impregnated gel dressing on clinically relevant microbes.
