Effects of XXXX -enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic @entity35 .

@entity295 @entity1568 @entity2228 @entity5 @entity11264 @entity568 @entity4022 @entity5698 @entity534 @entity35 @entity369 @entity8856
OBJECTIVES: Previous reports have shown that oral @entity369 ( @entity534 ) has immune-enhancing properties in injury. However, the effects of parenterally infused @entity534 on @entity295 are not well understood. We used a septic @entity35 model to study @entity534 infusion in inflammatory-related cytokines and blood T lymphocyte population in vivo. METHODS: @entity35 with internal jugular catheters were assigned to one of two groups. Both groups received isonitrogenous total parenteral nutrition (TPN) supplemented with 270 mg of @entity1568 per kilogram per day as @entity534 or @entity2228 ( @entity4022 ). TPN provided 270 kcal/kg of body weight, and the kilocalorie: @entity1568 ratio was 143:1. TPN was maintained for 5 d plus 2, 4, or 6 h or 6 d, according to the scheduled deaths of the @entity35 . On day 5, @entity295 was induced by cecal ligation and puncture (CLP). After CLP for 2, 4, 6, and 24 @entity5698 were killed. RESULTS: The results showed that interleukin-1beta and @entity5 necrosis factor-alpha concentrations in peritoneal lavage fluid at 6 h and @entity568 levels at 24 h after CLP in the @entity4022 group were significantly higher than those in the @entity534 group. The T-lymphocyte population in blood showed that CD8(+) suppressor T-cell number was significantly higher in the @entity4022 group than in the @entity534 group at 6 h after CLP. The blood @entity11264 (+):CD8(+) ratio was significantly higher in the @entity534 group than in the @entity4022 group at 24 h after CLP. A negative @entity1568 balance was observed in the @entity534 and @entity4022 groups after CLP; there was no significant difference in @entity1568 balance between the septic groups. No difference in survival rate at 24 h after CLP was observed between the groups. CONCLUSIONS: The results showed that, compared with the @entity4022 group, @entity8856 preinfused with @entity534 reduces the production of inflammatory mediators at the site of injury and that cellular immunity is enhanced at 24 h after CLP. Parenterally administered @entity534 had no beneficial effect in preventing @entity1568 loss and improving survival in septic @entity35 . Whether @entity4022 has specific effects that reduce the effects of @entity534 require further investigation.
