Radiosurgery for residual or recurrent nonfunctioning XXXX .

@entity1 @entity5 @entity977 @entity652 @entity942
OBJECT: Nonfunctioning @entity977 comprise approximately 30% of all @entity977 . The purpose of this retrospective study is to evaluate the efficacy and role of gamma knife radiosurgery (GKS) in the management of residual or recurrent nonfunctioning @entity977 . METHODS: A review was conducted of the data obtained in 42 @entity1 who underwent adjuvant GKS at the University of Pittsburgh between 1987 and 2001. Prior treatments included transsphenoidal resection, craniotomy and resection, or conventional radiotherapy. Endocrinological, ophthalmological, and radiological responses were evaluated. The duration of follow-up review varied from 6 to 102 months (mean 31.2 months). Fifteen @entity1 were observed for more than 40 months. The mean radiation dose to the @entity5 margin was 16 Gy. Conformal radiosurgery planning was used to restrict the dose to the optic nerve and chiasm. Tumor control after GKS was achieved in 100% of @entity1 with microadenomas and 97% of @entity1 with macroadenomas. Gamma knife radiosurgery was equally effective in controlling @entity652 with cavernous sinus invasion and suprasellar extension. No @entity1 developed a new @entity942 following GKS. One @entity1 's @entity5 enlarged with an associated decline in visual function. Another @entity1 experienced a deterioration of visual fields despite a decrease in @entity5 size. CONCLUSIONS: Gamma knife radiosurgery can achieve @entity5 control in virtually all residual or recurrent nonfunctioning @entity977 . Dose sparing facilitates @entity5 management even when the @entity652 is close to the optic apparatus or invades the cavernous sinus.
