XXXX among solid organ recipients in a tertiary care hospital, the Netherlands, 2006 - 2014.

@entity1 @entity281 @entity1800
OBJECTIVES: Since recent years, it is known that immunocompromised @entity1 can suffer of prolonged norovirus symptoms and @entity1800 up to multiple years. Little is known about the prevalence of chronic norovirus infection among solid organ transplant (SOT) recipients. In this study 2182 SOT recipients were retrospectively tested for chronic norovirus infection. METHODS: The first and last norovirus positive faecal sample of SOT recipients was sequenced to distinguish between persisting and re-infection. @entity1 charts were reviewed to obtain data on health statues and treatments. RESULTS: One hundred one of 2182 (4.6%) recipients were norovirus infected and 23 (22.8%) of these developed chronic norovirus infection. @entity281 was found among allogeneic heart-, kidney-, and lung transplant recipients. The median shedding period at the end of the study period was 218 days (range 32-1164). CONCLUSIONS: This study shows that chronic norovirus infection is not a rare phenomenon among SOT recipients in a tertiary care hospital exposed to norovirus. Further research is needed to study the risk of norovirus transmission to other immunocompromised @entity1 in the hospital and to the general population.
