Red cell distribution width and mortality in XXXX .

@entity1 @entity2998 @entity65 @entity299 @entity543 @entity204
BACKGROUND: Red cell distribution width (RDW) is associated with morbidity and mortality in chronic @entity299 . The aim of the present study was to investigate the role of RDW as a predictor of adverse outcome in @entity1 with @entity2998 . MATERIALS AND METHODS: We prospectively studied 1065 of 1286 consecutive @entity1 with neurological asymptomatic @entity543 as assessed by duplex Doppler sonography. The study endpoints were all-cause mortality and cardiovascular mortality respectively. RESULTS: During a median follow-up time of 6.2 years (interquartile range 5.9 to 6.6), corresponding to 5,551 overall @entity1 -years, 275 @entity1 (25.8%) died. Of these, 182 @entity1 (66.2%) died due to cardiovascular causes. RDW was significantly associated with adverse outcome. In a continuous multivariate Cox regression analysis, the adjusted hazard ratio for each percent increase in RDW was 1.39 (95% CI 1.27-1.53; p<0.001) for all-cause and 1.43 (95% CI 1.28-1.60; p<0.001) for cardiovascular mortality, respectively. Kaplan-Meier estimates showed a gradual relationship between increasing quartiles of RDW and @entity204 (log rank p<0.001). Adjusted hazard ratios for all-cause @entity204 ranged from 0.89 to 1.94 for the highest versus the lowest quartile (p<0.001 for trend) and for @entity65 from 1.08 to 2.34 for the highest versus the lowest quartile (p<0.001 for trend), respectively. CONCLUSIONS: RDW was significantly and independently associated with all-cause and @entity65 in @entity1 with asymptomatic @entity2998 . This article is protected by copyright. All rights reserved.
