@entity7832 rescues XXXX nephrogenesis during intrauterine growth restriction by regulating the complement and coagulation cascades and @entity460 signaling pathway.

@entity8 @entity101 @entity1592 @entity3147 @entity460 @entity35 @entity7832
UNASSIGNED: @entity1592 ( @entity1592 ) is associated with a reduction in the numbers of nephrons in neonates, which increases the risk of @entity101 . Our previous study showed that @entity7832 protects the development of the embryonic kidney during @entity1592 . To explore this molecular mechanism, @entity1592 @entity35 were induced by protein and calorie restriction throughout pregnancy, and @entity7832 was delivered using a mini osmotic pump. RNA sequencing technology was used to identify the differentially expressed genes (DEGs) of the @entity8 . DEGs were submitted to the Database for Annotation and Visualization and Integrated Discovery, and gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted. @entity3147 significantly reduced fetal weight, but @entity7832 treatment had no significant effect on body weight. A total of 322 (177 upregulated and 145 downregulated) DEGs were detected between control and the @entity1592 group. Meanwhile, 318 DEGs were found to be differentially expressed (180 increased and 138 decreased) between the @entity1592 group and the @entity7832 -treated group. KEGG pathway analysis indicated that maternal undernutrition mainly disrupts the complement and coagulation cascades and the @entity460 signaling pathway, which could be protected by @entity7832 treatment. Taken together, these two biological pathways may play an important role in nephrogenesis, indicating potential novel therapeutic targets against the unfavorable effects of @entity1592 .
