Accumulation of @entity1674 in the proximal tubule of the kidney in XXXX .

@entity1 @entity6 @entity13312 @entity1674 @entity14785 @entity204 @entity8557
AIMS: The present study was initiated by a very recent histochemical observation of lipid accumulation in the renal cortex of a @entity1 who died in a @entity14785 . Two older reports of lipid accumulation in the kidneys of @entity1 who died, most likely in a state of non-regulated @entity6 , supported this observation. We have examined whether lipid accumulation in the renal cortex is characteristic of @entity14785 and, if so, which type of lipid accumulates. METHODS: Three groups were studied. Ten subjects who died in a @entity14785 , eight @entity6 who died of known causes unrelated to @entity6 , and seven normal control subjects without any diagnosed @entity6 who died of known causes. All were subjected to histological examination for lipid accumulation in the renal cortex. Detailed analysis of cortex lipids was performed for two of the subjects who died in a @entity14785 and all @entity6 controls as well as non- @entity6 control subjects. RESULTS: All subjects who died in a @entity14785 showed @entity13312 staining strongly for lipid in the proximal tubules. Neither normal controls nor non-coma @entity6 showed these lesions. Compared with normal controls, renal cortex lipid was about tripled in the two analysed @entity14785 subjects due to 60-100-fold increases of @entity1674 . The non-coma @entity6 did not differ from the other controls with respect to @entity1674 or other types of lipid, except that @entity8557 were elevated, though still a quantitatively minor component. CONCLUSION: Our findings strongly indicate that @entity13312 in the proximal tubules are characteristic of @entity14785 and that they are caused by accumulated @entity1674 . Therefore, histological examination of renal cortex using a lipid stain may be a useful forensic tool in establishing @entity14785 as the cause of @entity204 .
