Relationship between the diuretic effect of XXXX and their ability to increase renal vascular resistance.

@entity2172 @entity4946 @entity1483 @entity35 @entity20307
The relationship between diuresis and natriuresis induced by @entity2172 ( @entity2172 ) and their renal haemodynamic effects were investigated. The effects of the iso-osmolar @entity20307 and the hyperosmolar diatrizoate on the renal vascular resistance (RVR) were studied in the filtering and non-filtering variants of the isolated perfused @entity35 kidney (IPRK) preparation. In the non-filtering model, no tubular regulatory process can be activated. The effect of diatrizoate on the RVR of the filtering IPRK in the presence of @entity1483 (0.3 mmol l-1) an inhibitor of the tubuloglomerular feedback (TGF) was also investigated. There was no significant difference (p > 0.05) in the response of the filtering (n = 6) and non-filtering (n = 6) IPRK to @entity20307 . The induced reduction in the renal perfusate flow (RPF) by @entity20307 was 20.5 +/- 3.05% and 22.9 +/- 3.03%, respectively. The reduction in the RPF which was observed with @entity4946 in the non-filtering IPRK (n = 5, 17.5 +/- 3.04%) was significantly less (p < 0.05) in comparison to that of the filtering IPRK (n = 6, 26.9 +/- 4.28%). In the frusemide experiments, a reduction in the RPF comparable to that of the non-filtering kidney was observed (n = 5, 13.7 +/- 4.34%). This study demonstrates that the renal vascular effect of diatrizoate is partially dependent on the TGF response. No tubular regulatory mechanism was accountable for the haemodynamic effect of @entity20307 . The activation of the tubular response is osmolarity dependent.
