[Facilitation of Shengjingbao to spermatogenesis in XXXX @entity19 models and its action mechanisms].

@entity251 @entity270 @entity70809 @entity19 @entity786 @entity29743 @entity6660
OBJECTIVE: To investigate the effects of @entity70809 on spermatogenesis in the @entity19 model of @entity6660 and its action mechanisms. METHODS: Sixty male @entity19 were randomly divided into 4 groups, Shengjingbao (Group 1), @entity270 (Group 2), blank model control (Group 3) and normal blank control (Group 4). The first three groups were treated by celiac injection of @entity786 for 5 successive days to make models, followed by intragastric administration of Shengjingbao and @entity270 to Group I and 2, respectively, for 36 days. And then all the @entity19 were sacrificed. The serum @entity251 (T) level was determined by radioimmunology, and a suspension was made from the testis and epididymis of one side for sperm analysis, while the testis of the other side was sliced up and stained by HE method and TUNEL technique to detect the count of Leydig cells, the layers of @entity29743 and the apoptosis of spermatogenic cells. RESULTS: Compared with Group 3, the serum T level, the layers of @entity29743 and the count of Leydig cells were obviously improved and even exceeded those in Group 2. The positive expression rate of spermatogenic cell apoptosis in Group 1 was evidently lower than Group 2 and 3. The above differences were statistically significant (P < 0.01 or P < 0.05), but no significant difference was noted between Group 1 and 4. CONCLUSION: Shengjingbao can significantly increase the count of Leydig cells, elevate the T level that influences the layers of @entity29743 , and thus enhance spermatogenesis. The action mechanisms of Shengjingbao may lie in its capacity of inhibiting the apoptosis of spermatogenic cells, increasing the layers of @entity29743 and facilitating spermatogenesis. T may play a role in inhibiting the apoptosis of spermatogenic cells.
