Modification of drug responses in partially hepatectomized XXXX of either sex by steroids.

@entity172 @entity3033 @entity1420 @entity72221 @entity72222 @entity4520 @entity382 @entity35
Male @entity35 with 2/3 of the liver removed were administered various drugs and chemical agents demonstrated to be stimulatory to the regenerating liver, mainly as supplements in a basal diet and injected with @entity4520 daily for the first 9 days p.o. (overall: 250-350 micrograms/kg), the animals being sacrificed on day 10. @entity172 inhibited liver regeneration in many of the drug-treated groups, the restored organ increments often falling to the range of the injected controls on the basal ration. The adult female displayed a lower sensitivity or more inconsistent responses to several drugs, and generally, @entity172 had a minor effect on the ensuing restored organ increment. As tested with a few agents, the behavior of adults ovariectomized 21 or 35 days prior to partial hepatectomy simulated that of the males. A group of compounds, including @entity72221 and @entity72222 , among others, was hepatotrophic to @entity35 of either sex and the increments were not altered by intervention of @entity172 . The inhibitory action of @entity4520 also extended to males fed the hormone as a dietary supplement. Moderate to high levels of @entity1420 or @entity3033 administered to females elicited liver increments much greater than those due to the drugs as such. In contrast to the partially hepatectomized series, the intact male displayed @entity382 with test agents but except for few, the inhibition due to @entity172 was lower. The intact female findings with several drugs appeared to be more consistent as compared to the liver increment data.
