Randomized trial of pallidotomy versus medical therapy for XXXX .

@entity1 @entity2003 @entity304 @entity910 @entity191 @entity2845 @entity400
Thirty-six @entity1 with @entity191 ( @entity191 ) were randomized to either medical therapy (N = 18) or unilateral GPi pallidotomy (N = 18). The primary outcome variable was the change in total Unified @entity191 Rating Scale (UPDRS) score at 6 months. Secondary outcome variables included subscores and individual @entity304 as determined from the UPDRS. At the six month follow-up, @entity1 receiving pallidotomy had a statistically significant reduction (32% decrease) in the total UPDRS score compared to those randomized to medical therapy (5% increase). Following surgery, @entity1 ' showed improvement in all the cardinal motor signs of @entity191 including @entity400 , @entity2003 , @entity2845 , gait and balance. @entity910 were also markedly improved. Although the greatest improvement occurred on the side contralateral to the lesion, significant ipsilateral improvement was also observed for @entity2845 , @entity2003 and @entity910 . A total of twenty @entity1 have been followed for 2 years to assess the effect of time on clinical outcome. These @entity1 have shown sustained improvement in the total UPDRS (p < 0.0001), "off" motor (p < 0.0001) and complications of therapy subscores (p < 0.0001). Sustained improvement was also seen for @entity400 , @entity2003 , @entity2845 , percent on time and @entity910 .
