Ultrastructural and molecular heterogeneity in XXXX : study of 110 cases and review of the literature.

@entity5 @entity957 @entity1149 @entity2 @entity4910 @entity133 @entity1544 @entity152 @entity420
The authors reviewed a series of 110 surgical specimens of primary @entity1149 from the Department of Pathology at the Hospital Clinic, University of Barcelona Medical School, between 1987 and 1997. The sample included 25 @entity957 , 60 @entity420 , 14 @entity152 , and 11 @entity5 . Electron microscopic subcellular characteristics of the @entity2 cells were studied to define the squamous, adenoid, or neuroendocrine differentiation in each @entity5 . An immunohistochemical study for @entity4910 was performed in 96 cases. In 71 cases (65%) the author found a single ultrastructural differentiation, and in 30 cases (27%) ultrastructural differentiation was double: 25 adenosquamous and 5 adeno-neuroendocrine. In 3 cases a triple adeno- @entity1544 was found. There were no cases of @entity1544 . In 6 cases no differentiation of any kind could be found. @entity4910 overexpression was found in 58% of all @entity5 . The positive expression rates in @entity957 and @entity420 were 72% and 62%, respectively. In purely adenoid-differentiated @entity5 there was a strong association between high @entity4910 overexpression and differentiation (p=.006). In @entity133 the positivity rate was 70%; all were heavy expressers, compared with 25% of heavy expressers in @entity420 as a whole (p<.005). In purely squamous @entity5 differentiated ultrastructurally no relationship was found between high @entity4910 expression and degree of differentiation (p=.08). @entity2 are morphologically and molecularly heterogeneous, and certain molecular alterations are related to specific subcellular characteristics.
