Muscular dystrophy in a litter of golden retriever XXXX .

@entity101 @entity235 @entity908 @entity1184 @entity12296 @entity1555 @entity121
Clinicopathologic findings from two golden retriever @entity235 with an inherited, progressive, @entity121 that were studied until 27 and 40 months of age are described. Initial clinical signs included stilted gait and simultaneous advancement of their pelvic limbs. Further gait restriction and muscle @entity1184 eventually occurred. Serum @entity908 kinase was dramatically elevated (greater than 10,000 U/L). There were persistent "spontaneous" high-frequency discharges ( @entity12296 ) on electromyographic evaluation. Features of both muscle fiber degeneration (hyaline fibers, myophagocytosis) and regeneration (small basophilic fibers) were seen on light microscopy. Similar ultrastructural changes (fiber hypercontraction, @entity101 ) were present. On morphometric histochemical evaluation, mean fiber diameter of both type 1 and 2 fibers was increased compared with controls in two of three muscles examined. There was no apparent fiber type predominance. Scattered ragged red fibers were seen, but this appeared to be a nonspecific finding of either muscle fiber regeneration or degeneration. These findings and potential contributing pathophysiologic mechanisms are discussed in relation to @entity1555 .
