Subjective Memory Complaints in XXXX Carriers are Associated with High Amyloid-b Burden.

@entity1 @entity2414 @entity195 @entity2204
BACKGROUND: @entity2204 genotype and aging have been identified as risk factors for @entity195 ( @entity195 ). In addition, @entity2414 ( @entity2414 ) might be a first clinical expression of the effect of @entity195 pathology on cognitive functioning. OBJECTIVE: To assess whether @entity2204 genotype, age, @entity2414 , and episodic memory are risk factors for high amyloid-b (Ab) burden in cognitively normal elderly. METHODS: 307 cognitively normal @entity1 (72.7    6.8 years, 53% female, 55% @entity2414 ) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and @entity2204 genotyping. Logistic regression analyses were performed to determine the association of @entity2204 genotype, age, @entity2414 , and episodic memory with Ab pathology. RESULTS: Odds of high Ab burden were greater at an older age (OR=3.21; 95% CI=1.68-6.14), when @entity2414 were present (OR=1.90; 95% CI=1.03-3.48), and for @entity2204 carriers (OR=7.49; 95% CI=3.96-14.15), while episodic memory was not associated with odds of high Ab burden. Stratified analyses showed that odds of @entity2414 for high Ab burden were increased in specifically @entity2204 carriers (OR=4.58, 95% CI=1.83-11.49) and younger @entity1 (OR=3.73, 95% CI=1.39-10.01). CONCLUSION: Aging, @entity2204 genotype, and @entity2414 were associated with high Ab burden. @entity2414 were especially indicative of high Ab burden in younger @entity1 and in @entity2204 carriers. These findings suggest that selection based on the presence of @entity2414 , @entity2204 genotype and age may help identify healthy elderly @entity1 with high Ab burden eligible for secondary prevention trials.
