@entity777 -dependent influence of nociceptive sensory neurons on XXXX .

@entity32 @entity9683 @entity625 @entity2047 @entity19 @entity4 @entity777 @entity158 @entity12819 @entity13624
INTRODUCTION: @entity777 ( @entity777 ) is an important mediator of @entity32 . In addition to cells involved in @entity32 , sensory nociceptive neurons express the @entity777 signal-transducer @entity9683 ( @entity9683 ). These neurons are not only involved in @entity158 generation but also produce @entity13624 by release of neuropeptides such as @entity12819 ( @entity12819 ). Whether @entity777 activation of sensory neurons contributes to the induction of @entity32 is unknown. This study explored whether the action of @entity777 on sensory neurons plays a role in the generation of @entity13624 and @entity625 induction. METHODS: In SNS- @entity9683 (-/-) @entity19 lacking @entity9683 selectively in sensory neurons and appropriate control littermates (SNS- @entity9683 (flox/flox)), we induced @entity625 ( @entity625 ), and assessed @entity4 , histopathological @entity625 scores, @entity158 scores, expression of @entity12819 in sensory neurons, serum concentrations of @entity12819 and cytokines, and the cytokine release from single cell suspensions from lymph nodes and spleens. In wild-type @entity19 @entity12819 release was determined during development of @entity625 and, in cultured sensory neurons, upon @entity777 stimulation. RESULTS: Compared to SNS- @entity9683 (flox/flox) @entity19 SNS- @entity9683 (-/-) @entity19 showed significantly weaker @entity4 , reduced serum concentrations of @entity12819 , @entity777 , and @entity2047 , no @entity32 -evoked upregulation of @entity12819 in sensory neurons, but similar histopathological @entity625 scores during @entity625 . During the @entity4 phase of @entity625 , @entity12819 was significantly increased in the serum, knee and spleen. In vitro, @entity777 augmented the release of @entity12819 from cultured sensory neurons. Upon antigen-specific restimulation lymphocytes from SNS- @entity9683 (-/-) @entity19 released more interleukin-17 and interferon-y than lymphocytes from SNS- @entity9683 (flox/flox) @entity19 . In naive lymphocytes from SNS- @entity9683 (flox/flox) and SNS- @entity9683 (-/-) @entity19 @entity12819 reduced the release of @entity2047 (a cytokine which inhibits the release of interleukin-17 and interferon-y). CONCLUSIONS: @entity777 signaling in sensory neurons plays a role in the expression of @entity625 . Selective deletion of @entity9683 signaling in sensory neurons reduces the @entity4 of the joint (most likely by reducing @entity13624 ) but increases some proinflammatory systemic cellular responses such as the release of interleukin-17 and interferon-y from lymphocytes upon antigen-specific restimulation. Thus @entity777 signaling in sensory neurons is not only involved in @entity158 generation but also in the coordination of the inflammatory response.
