Ethanolamine oleate versus botulinum toxin in the treatment of idiopathic XXXX .

@entity1318 @entity1 @entity384 @entity21780
BACKGROUND: Botulinum toxin (BT) injection reduces lower esophageal sphincter pressure and alleviates symptoms in idiopathic @entity1318 (IA). @entity21780 (EO) has also been introduced for the treatment of IA. We compared the long-term efficacy of BT and EO injections in the treatment of IA. METHODS: A total of 189 IA @entity1 were evaluated prospectively, of whom 21 were unwilling to undergo or were poor candidates for @entity384 and Heller myotomy and were enrolled in the study. Eleven @entity1 were treated by BT, and 10 by EO injections. @entity1 were followed up by @entity1318 symptom score (ASS), timed barium esophagogram (TBE), and high-resolution manometry at baseline and post-treatment. A good initial response was defined as a decrease in ASS to 4 or less, and a reduction in barium column height and volume in TBE by >50%. RESULTS: All 10 EO group @entity1 and 10 of 11 BT group @entity1 showed a good initial response. Four EO group relapsers and 6 BT group relapsers were managed effectively by re-injections. Mean duration of follow up was 27.38 months. On completion of the study, a sustained good response was seen in 9 and 6 @entity1 in EO and BT groups, respectively (P=0.149). CONCLUSION: This study revealed that BT and EO have comparable efficacy in the treatment of IA. However, the cost of EO is about 2 times lower than BT.
