Prognostic Value of Tumor-Associated Macrophages According to Histologic Locations and XXXX Status in @entity0 .

@entity0 @entity5 @entity876 @entity3546 @entity16235 @entity2277 @entity5282
UNASSIGNED: Tumor-associated macrophages (TAMs) are involved in @entity5 progression by promoting epithelial-mesenchymal transition (EMT), @entity5 cell invasion, migration and angiogenesis. However, in @entity0 , the clinical relevance of the @entity16235 infiltration according to distinct histologic locations (intratumoral vs. stromal) and @entity5282 status is unclear. We investigated the significance of the levels of @entity16235 infiltration in distinct histologic locations in invasive @entity0 . We also examined the relationship of the @entity16235 levels with the clinicopathologic features of @entity5 , expression of EMT markers, and clinical outcomes. Finally, we analyzed the prognostic value of @entity16235 levels according to @entity5282 status. High levels of infiltration of intratumoral, stromal and total TAMs were associated with high histologic grade, @entity876 overexpression, high Ki-67 proliferation index and negative @entity5282 status. Infiltration of TAMs was also correlated with overexpression of @entity2277 , smooth muscle actin and alteration of @entity3546 . Overall, a high level of infiltration of intratumoral TAMs was associated with poor disease-free survival, and was found to be an independent prognostic factor. In subgroup analyses by @entity5282 status, a high level of infiltration of intratumoral @entity16235 was an independent prognostic factor in the @entity5282 -positive subgroup, but not in the hormone-receptor negative subgroup. Our findings suggest that intratumoral TAMs play an important role in @entity5 progression in @entity0 , especially in the @entity5282 -positive group, and the level of @entity16235 infiltration may be used as a prognostic factor and even a therapeutic target in @entity0 .
