Efficacy and safety study of XXXX cream 0.1% for the treatment of @entity5806 .

@entity1 @entity5806 @entity6987 @entity555
@entity5806 refers to nails that exhibit surface roughness, raggedness, and peeling. It is a common problem, with a higher prevalence among elderly @entity1 . The goal of this study was to determine if @entity555 cream 0.1% ameliorates the signs and symptoms of brittle nails. In this open-label, single-center trial, @entity1 applied @entity555 cream to the nails twice daily for 24 weeks. Signs and symptoms were rated by the investigators and by the @entity1 during treatment and 12 weeks after discontinuation. Twenty @entity1 were enrolled in the study; 1 @entity1 withdrew prior to the 4-week followup visit. Of the 18 @entity1 available for analysis (1 @entity1 was excluded because baseline photographs were not available) for the primary end point of improvement in the physician global improvement assessment (PGIA), all 18 @entity1 achieved improvement of the target nails at week 12 as well as 16 @entity1 (88.9%) at week 24. All 18 @entity1 had improvement in the PGIA score 12 weeks posttreatment at week 36. The physician global assessment (PGA) improved for 14 of 19 @entity1 (73.7%) at both weeks 12 and 24; at week 24, 4 of 19 @entity1 had achieved a @entity6987 score of none. At week 36, 17 of 19 @entity1 (89.5%) agreed that their nails had improved overall. Only 1 @entity1 (5.3%) reported mild local irritation. This study demonstrated that @entity555 improves some of the changes noted in conjunction with @entity5806 with minimal to no irritation.
