Fat intake affects adiposity, comorbidity factors, and energy metabolism of XXXX .

@entity844 @entity28 @entity1735 @entity1017 @entity412 @entity35 @entity413 @entity165
OBJECTIVE: @entity28 is an emerging health problem. This study assesses the effects of three levels of dietary fat (10%, 32%, and 45% measured by kilocalories) on @entity1017 , body composition, energy metabolism, and comorbidity factors in @entity35 from weaning through maturation. RESEARCH METHODS AND PROCEDURES: The role of dietary fat on the susceptibility to @entity28 was assessed by feeding diets containing three levels of dietary fat to @entity35 from weaning through 7 months of age. Body composition was analyzed by DXA after 6 and 12 weeks of dietary treatment. Energy metabolism was measured by indirect calorimetry. RESULTS: Energy intake, @entity1017 , fat mass, and plasma @entity413 , @entity165 , @entity412 , free @entity844 , leptin, and insulin levels increased dose-dependently with increased dietary fat. No difference in absolute lean mass among the three groups was observed. Therefore, the differences in @entity1017 are accounted for primarily by increased fat accretion. Compared with @entity35 that were relatively resistant to @entity28 when on a 45% fat diet, diet-induced @entity28 -prone @entity35 were in positive energy balance and had an elevated respiratory quotient, indicating a switch in energy substrate use from fat to @entity1735 , which promotes body-fat accretion. DISCUSSION: Our data support the hypothesis that administration of increasing amount of dietary fat to very young @entity35 enhances susceptibility to diet-induced @entity28 and its comorbidities.
