XXXX detection: 8 versus 12-core biopsy protocol.

@entity1 @entity263 @entity5
PURPOSE: We compared @entity263 detection rates achieved using an 8 and 12-core biopsy protocol in a clinical population to determine the significance of additional transition zone sampling on repeat biopsy. MATERIALS AND METHODS: Between September 2004 and September 2007, 269 eligible @entity1 with a clinical suspicion of @entity263 referred to our department were randomized to an 8-core lateral (group 1) or a 12-core lateral and parasagittal (group 2) transrectal ultrasound guided prostate biopsy protocol. Study inclusion criteria were age dependent increased serum prostate specific antigen (1.25 ng/ml or greater at ages less than 50 years, 1.75 or greater at ages 50 to less than 60 years, 2.25 or greater at ages 60 to less than 70 years and 3.25 or greater at ages 70 years or greater), positive digital rectal examination and/or suspicious transrectal ultrasound. After negative first round biopsy @entity1 underwent 12-core biopsy, including 4 transition zone cores. RESULTS: Nine @entity1 were excluded from analysis because of protocol violation or they did not complete the whole biopsy procedure due to discomfort. The @entity5 detection rate in groups 1 and 2 did not differ significantly (34.1% or 45 of 132 @entity1 and 38.3% or 49 of 128, respectively, p = 0.48). @entity5 median Gleason scores were similar in the groups. Of 109 @entity1 who underwent repeat biopsy @entity263 was detected in 20 (14.4%), of whom 9 had positive cores from the transition zone and 6 had positive biopsies only from the transition zone. CONCLUSIONS: There are no statistically significant differences in the @entity263 detection rate between 8 and 12-core prostate biopsy protocols. Transition zone biopsies contribute to @entity263 detection in a repeat biopsy protocol.
