[The effectiveness of hemopoietic growth factors in XXXX ].

@entity295 @entity2905 @entity7420 @entity35 @entity7421
In this experimental study, consist of 54 @entity35 , we tried to observe the effectiveness of haemopoietic growth factors such as @entity7420 and @entity7421 in treatment of @entity295 and see if they have any effects on phagocytic activity of macrophages when are administered after establishment of @entity295 . In first phase of this study, twenty one @entity35 were randomly divided into three groups of 7 animals each. Cecal ligation and perforation were carried out in each @entity35 and @entity295 made up. The Control group received 2 x 0.2 cc %5 dextrose injection subcutaneous (s.c.).. The @entity7420 group received 2 x 1 g @entity7420 with 0.2 cc %5 dextrose s.c. The @entity7421 received 1 x 2 g @entity7421 with 0.2 cc %5 dextrose s.c. Seventh day survival was considered as criterion in the three groups. In second phase of this study, thirty three @entity35 were randomly divided into three groups of 11 animals each. The same procedures were carried out also in these groups. Leukocyte counts and peripheric spread were analyzed in postoperative 24th and 72th hours, alveolar and peritoneal macrophages were Investigated in postoperative 72nd hour. There was significantly neutrophilic leukocytosis in the @entity7420 group according to the control group. Nevertheless, there was no change in the phagocytic activity of alveolar and peritoneal macrophages. @entity7421 brought about positive effect of phagocytic activity of macrophages without change of leucocyte count in the @entity295 , but it caused neutrophilic, monocytosis and @entity2905 . The seventh day survival rates in control, @entity7420 , @entity7421 groups were as; 42.8%, 71.4%, 28.5% respectively. As a result, we saw that @entity7420 has no effect on the phagocytic activity of macrophages, while increases the survival by enhancing the count and probably the function of neutrophils. @entity7421 fails to increase survival while effects the phagocytic activities of macrophages positively and enhances the peripheral neutrophil and monosit counts without changing the total number of leukocytes.
