Population-based SEER trend analysis of overall and XXXX -specific survival in 5138 @entity1 with gastrointestinal stromal tumor.

@entity1 @entity677 @entity5 @entity3
BACKGROUND: The objective of the present population-based analysis was to assess survival patterns in @entity1 with resected and metastatic @entity677 . METHODS: @entity1 with histologically proven @entity677 were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 through 2011. Survival was determined applying Kaplan-Meier-estimates and multivariable Cox-regression analyses. The impact of size and mitotic count on survival was assessed with a generalized receiver-operating characteristic-analysis. RESULTS: Overall, 5138 @entity1 were included. Median age was 62  years (range: 18-101 years), 47.3  % were female, 68.8  % Caucasians. @entity677 location was in the stomach in 58.7  % and small bowel in 31.2  %. Lymph node and distant @entity3 were found in 5.1 and 18.0  %, respectively. For non-metastatic @entity677 , three-year overall survival increased from 68.5  % (95 % CI: 58.8-79.8  %) in 1998 to 88.6  % (95 % CI: 85.3-92.0  %) in 2008, @entity5 -specific survival from 75.3  % (95 % CI: 66.1-85.9  %) in 1998 to 92.2  % (95 % CI: 89.4-95.1  %) in 2008. For metastatic @entity677 , three-year overall survival increased from 15.0  % (95 % CI: 5.3-42.6  %) in 1998 to 54.7  % (95 % CI: 44.4-67.3  %) in 2008, @entity5 -specific survival from 15.0  % (95 % CI: 5.3-42.6  %) in 1998 to 61.9  % (95 % CI: 51.4-74.5  %) in 2008 (all PTrend   <   0.05). CONCLUSIONS: This is the first SEER trend analysis assessing outcomes in a large cohort of @entity677 @entity1 over a 11-year time period. The analysis provides compelling evidence of a statistically significant and clinically relevant increase in overall and @entity5 -specific survival from 1998 to 2008, both for resected as well as metastatic @entity677 .
