Analysis of @entity517 DNA amplification in XXXX in comparison with small cell lung carcinoma using polymerase chain reaction.

@entity4153 @entity5 @entity957 @entity1149 @entity2 @entity517 @entity1859 @entity189 @entity152 @entity420
Previous studies of c-mvc DNA amplification in @entity2 have focused primarily on analysis of @entity4153 or its @entity5 cell lines. There are few data about @entity517 DNA amplification in histological types of @entity2 other than @entity4153 . Therefore the present study was conducted to investigate @entity517 oncogene amplification in @entity1149 . We studied 46 @entity2 specimens for @entity517 DNA amplification (15 @entity420 , 15 @entity957 , 6 @entity152 , and 10 @entity4153 ). Polymerase chain reaction, @entity1859 DNA labeling, and electrophoresis were utilized to investigate the @entity517 copy number in the @entity2 specimens. The @entity517 copy number of @entity4153 ranged from 1.5 to more than 20.0 in @entity420 and @entity957 , and from 6.0 to 12.0 in @entity152 . That of @entity4153 ranged from 1.8 to 12.0. The @entity517 copy number of @entity4153 was significantly higher than that of @entity4153 (Wilcoxon rank sum test, Z=2.06 P=0.040). However, the differences in @entity517 copy number among these four histological types were not statistically significant. Amplification of @entity517 (more than 4 copies) was observed not only in @entity4153 but also in nonsmall cell @entity189 at similarly high frequency (12/15 in @entity420 and @entity957 , 6/6 in @entity152 , and 9/10 in @entity4153 ).
