@entity70722 : A potential sign of rapidly progressing XXXX .

@entity1 @entity70722 @entity66 @entity75 @entity1694 @entity405
BACKGROUND: @entity70722 was noted in @entity1 reporting recent worsening of @entity1694 . OBJECTIVE: We sought to determine if @entity70722 -like depigmentation is a marker of rapidly progressing @entity1694 . METHODS: Review of @entity1 records and images of @entity1 from a @entity1694 registry resulted in 7 @entity1 with 12 images that fit inclusion criteria and were evaluated for percent depigmentation by 3 independent reviewers. The @entity66 Activity Score and the Koebner Phenomenon in Vitiligo Score in an additional cohort of @entity1 with @entity75 were compared with @entity1 who had @entity1694 without @entity75 . RESULTS: The mean percentage of depigmentation at baseline was 19.2%, which increased to 43.9% in images obtained at a mean of 16  weeks of follow-up. @entity66 Activity Score and Koebner Phenomenon in Vitiligo Score were significantly higher in the @entity1 with @entity75 compared with those without @entity75 . A skin biopsy specimen of a @entity70722 -like lesion in 1 @entity1 revealed an inflammatory infiltrate in the papillary dermis with @entity405 (+) T cells localized to the dermoepidermal junction. LIMITATIONS: Small, single-center retrospective review and lack of full-body photographs are limitations. CONCLUSIONS: A @entity70722 -like pattern of depigmentation may be a negative prognostic indicator for @entity1 with rapidly progressing @entity1694 . Further, prospective studies to evaluate this physical finding should be performed.
