Effect of adjuvant perioperative desmopressin in locally advanced @entity235 XXXX and its relation to histologic grade.

@entity1 @entity7062 @entity5 @entity235 @entity189 @entity3459
@entity7062 ( @entity7062 ) is a vasopressin peptide analog with hemostatic properties that has been successfully used during surgery in @entity1 with @entity3459 . Recently published experimental and clinical data indicate that perioperative administration of @entity7062 can minimize spread and survival of residual mammary @entity5 cells. The central aim of this study was to explore the effect of perioperative @entity7062 and its relation to histologic grade in bitches with locally advanced @entity189 . Of the 32 @entity235 initially recruited, 28 intact bitches with @entity189 tumors stage III or IV were ultimately included. These @entity235 were randomized to receive @entity7062 at intravenous doses of 1  g/kg (n=18) or saline solution as placebo (n=10). En bloc mastectomy of the affected gland(s) was performed. @entity5 was graded by the method of Elston and Ellis into well-differentiated (grade 1), moderately differentiated (grade 2), or poorly differentiated (grade 3). @entity7062 therapy significantly prolonged the disease-free survival (P<0.001) and overall survival (P<0.01) in bitches with grade 2 or 3 @entity189 compared with bitches in the control group. No significant difference in disease-free period or overall survival was found between treatment groups in bitches with grade 1 @entity5 . The present data suggest that @entity7062 may be an excellent candidate as a surgical adjuvant in the management of @entity5 in small animals. More research in this field is warranted.
