Renal function and long-term survival after hospital discharge in XXXX with preserved ejection fraction.

@entity1 @entity8 @entity712 @entity177 @entity955 @entity65 @entity1002
BACKGROUND: Baseline renal function and @entity177 ( @entity177 ) during hospitalization for @entity712 ( @entity712 ) have a major prognostic impact in @entity1 with @entity1002 . METHODS: We sought to prospectively investigate the impact of reduced baseline renal function and @entity177 during hospitalization on the 7-year outcome in 358 @entity1 surviving a first admission to hospital for @entity712 with preserved (>=  50%) ejection fraction (HFPEF). RESULTS: Mean baseline estimated glomerular filtration rate (eGFR) was 59.4    23.6 ml/min/1.73 m  . Low admission eGFR (<60 ml/min/1.73 m  ) was frequently observed (190 @entity1 --53% of the study population). Low baseline eGFR was associated with an increased risk of 7-year overall mortality (unadjusted hazard ratio [HR] 1.43[1.10-1.86]; p = 0.007) and @entity65 (unadjusted HR 1.57[1.13-2.19]; p = 0.007). After adjustment for covariates, the relationships remained significant. During hospitalization, @entity177 occurred in 43 @entity1 (12%). History of @entity177 , baseline systolic blood pressure >160 mm Hg, and baseline @entity955 were independent predictors of the development of @entity177 during hospitalization. @entity177 was independently predictive of 7-year overall mortality (adjusted HR 2.10[1.24-3.58]; p = 0.006) and @entity65 (adjusted HR 2.54[1.35-4.78]; p = 0.004) in @entity1 with low baseline eGFR but not in those with baseline eGFR >=  60 ml/min/1.73 m  . CONCLUSIONS: In @entity1 admitted for the first time for HFPEF, low baseline eGFR is a potent predictor of long-term mortality. @entity1 with @entity8 at baseline who develop @entity177 during hospitalization have particularly poor prognosis.
