Application of two different hemostatic procedures during microsurgical median nerve reconstruction in the XXXX does not hinder axonal regeneration.

@entity1 @entity162 @entity16 @entity86 @entity35
BACKGROUND: Hemostatic procedures by means of electrical coagulation or application of topical agents are widely used to avoid @entity86 during microsurgical reconstruction of peripheral nerves. It is speculated, however, that extensive hemostasis could provoke @entity16 . OBJECTIVE: To examine the effects of 2 intraoperative hemostatic procedures on peripheral nerve regeneration. METHODS: In 36 adult @entity35 divided into 3 groups, the median nerve was transected and repaired by end-to-end neurorrhaphy. During surgery, bleeding was treated in groups 2 and 3 by application of either the topical hemostatic agent Floseal or routine @entity162 . The degree of nerve regeneration was assessed in terms of motor function recovery using weekly grasping test evaluation for 3 months, muscle mass recovery of flexor digitorum sublimis, and stereological assessment of myelinated axon regeneration. RESULTS: Neither of the 2 applied hemostatic methods induced any negative effects on nerve regeneration as defined by grip strength, muscle mass recovery, and morphology of myelinated nerve fibers. In contrast, Floseal-treated animals showed a faster progression of motor function recovery, and animals subjected to @entity162 revealed a higher muscle mass recovery compared with the control group. CONCLUSION: Controlled application of @entity162 or Floseal does not exert a negative effect on the nerve regeneration outcome in @entity35 . We propose that these methods can be applied safely to @entity1 .
