XXXX Gene Polymorphisms are Associated with Risk of Tetralogy of Fallot.

@entity1 @entity31561 @entity66945 @entity7 @entity215 @entity24279
BACKGROUND The aim of this study was to investigate associations of 3 common polymorphisms in the @entity7 gene, @entity24279 , @entity31561 , and @entity66945 , with risk of @entity215 ( @entity215 ) in Chinese Han @entity1 . MATERIAL AND METHODS From January 2010 to June 2013, a total of 400 pediatric subjects were recruited, including 160 cases with @entity215 ( @entity215 group) and 240 healthy controls (control group). The genotypes of 3 common @entity7 polymorphisms, @entity24279 , @entity31561 , and @entity66945 , were analyzed by polymerase chain reaction restriction fragment length polymorphism. All data were analyzed with SPSS 18.0 software. RESULTS No significant differences were observed in body mass index or sex between @entity215 @entity1 and controls (both P>0.05), but significant differences in age and family history of @entity215 were observed between the 2 groups (both P<0.05). The AA genotype in @entity24279 of @entity7 was correlated with a significantly increased risk of @entity215 , and @entity215 risk in A allele carrier was 1.54-fold higher than that of C allele carrier (OR=1.54, 95%CI=1.14-2.09, P=0.005); the statistical significance was still present after Bonferroni correction (Pc=0.045). GG genotype in @entity31561 of @entity7 gene was also associated with an increased risk of @entity215 , and @entity215 risk in @entity1 with G allele was 1.62-fold higher compared to @entity1 with C allele (OR=1.62, 95%CI=1.19-2.21, P=0.002); the statistical significance was still present after Bonferroni correction (Pc=0.018). Interestingly, T allele in @entity7 @entity66945 polymorphism is associated with a decreased @entity215 risk (OR=0.65, 95%CI=0.49-0.87, P=0.003, the statistical significance was still present after Bonferroni correction (Pc=0.027). The result of logistic regression analysis revealed that @entity24279 , @entity31561 , and @entity66945 genotypes are independently related to the prevalence of @entity215 (all P<0.05). CONCLUSIONS Our results confirmed that @entity7 genetic polymorphisms, @entity24279 and @entity31561 , may be associated with an increased @entity215 risk, while @entity66945 polymorphism may be associated with decreased @entity215 risk.
