Enteral feeding of a chemically defined diet preserves pulmonary immunity but not intestinal immunity: the role of XXXX .

@entity19 @entity29956 @entity6841 @entity1681
BACKGROUND: Compared with chow or a @entity1681 ( @entity1681 ), IV administration of a parenteral nutrition solution ( @entity6841 ) impairs intestinal and respiratory mucosal immunity, resulting in cellular and immunoglobulin A (IgA) defects in the intestine and impaired respiratory antiviral and antibacterial defenses. @entity6841 given intragastrically (IG- @entity6841 ) impairs intestinal immunity similar to @entity6841 but preserves antiviral defences and partially preserves antibacterial defenses. @entity29956 ( @entity29956 ) is a molecule essential for development and organization of lymphoid tissue. It controls many molecules important in mucosal immune integrity. This study examines effects of route (IV or enteral) and type ( @entity6841 , @entity1681 , or chow) on @entity19 intestine and lung @entity29956 expression. METHODS: Forty-three @entity19 randomly received @entity6841 (n = 12), IG- @entity6841 (n = 11), IV saline + chow (chow; n = 11), or a @entity1681 (n = 9). After 5 days of feeding, intestinal and lung samples were obtained and processed for levels of @entity29956 by Western blot. RESULTS: @entity6841 significantly reduced intestinal and lung @entity29956 compared with @entity1681 and chow. IG- @entity6841 reduced @entity29956 levels only in the intestine but preserved lung levels. CONCLUSIONS: Route and type of nutrition differentially influence molecular events in the intestinal and respiratory mucosal immune systems. Enteral feeding with any diet (complex or chemically defined) maintains lung @entity29956 expression, whereas intestinal @entity29956 levels are maintained only with CEDs (chow and @entity1681 ). We hypothesize that @entity29956 is responsible for the observed preservation of respiratory tract immunity with administration of a noncomplex, chemically defined enteral diet, whereas intestinal immunity is compromised with this diet.
