Effect of regional @entity63 on the left ventricular end-systolic pressure-volume relation in chronically instrumented XXXX .

@entity1169 @entity308 @entity63 @entity235 @entity1563 @entity3897
The slope of the left ventricular end-systolic pressure-volume relation has been proposed as a sensitive index of left ventricular function since it increases in response to positive inotropic agents and decreases with global @entity308 of contractility. The effect of a segmental @entity308 of left ventricular contractile function produced by circumflex @entity1563 on the left ventricular end-systolic pressure-volume relation was evaluated in seven chronically instrumented @entity235 . Left ventricular volume was calculated from three ultrasonically measured, orthogonal left ventricular endocardial dimensions. Left ventricular pressure was measured with a micromanometer. The left ventricular end-systolic pressure-volume relation was generated by occlusion of the inferior vena cava, before and after inducing regional @entity63 , in the presence of autonomic blockade with @entity1169 and @entity3897 . The end-systolic data in each @entity235 , before and after @entity1563 , were fit to the equation, P = E(V - V0), with r greater than or equal to 0.95 in all cases. @entity1563 shifted the left ventricular end-systolic pressure-volume relation to the right in each animal. During regional @entity63 , the volume intercept (V0) increased from 10.1 +/- 7.8 to 20.4 +/- 9.8 ml (mean +/- SD) (p less than 0.005). The slope (E) of the left ventricular end-systolic pressure-volume relation was relatively unchanged. It is concluded that in intact @entity235 , regional left @entity63 resulting from @entity1563 produces a rightward shift of the left ventricular end-systolic pressure-volume relation.(ABSTRACT TRUNCATED AT 250 WORDS)
