[Clinical significance of serum XXXX in the course and prognosis of @entity384 ].

@entity1 @entity296 @entity712 @entity6211 @entity1184 @entity1283 @entity384 @entity1121 @entity299 @entity1718
Serum @entity6211 is an essential cofactor for the transport of free @entity1718 into the mitochondria. We determined the free and the total serum @entity6211 in 99 healthy blood donors and 58 @entity1 with different forms of @entity299 . Thirty @entity1 had dilated (DCM), 10 @entity1184 (HCM) and 8 alcoholic (ACM) @entity296 and 10 @entity1 had @entity712 of different etiology than @entity296 (CHF). Free and total serum @entity6211 were determined by an enzymatic-spectrophotometric assay according to Pearson. Mean values for free and total serum @entity6211 were as follows: 47 and 74 mumol/l in controls (C; blood donors), 74 (P less than 0.01 vs. C) and 83 mumol/l in DCM, 66 (P less than 0.01 vs. C) and 89 mumol/l in HCM, 85 (P less than 0.01 vs. C) and 104 mumol/l (P less than 0.05 vs. C) in ACM and 86 (P less than 0.01 vs. C) and 129 mumol/l (P less than 0.01 vs. C) in CHF. Ten @entity1 died during the mean observation time of 13 months, 8 @entity1 with DCM and 2 with CHF; 9 of these 10 @entity1 had initially a markedly increased serum @entity6211 . @entity1 with DCM were divided into two groups with normal (n = 15; 25-68 mumol/l) and increased (n = 15; greater than 68 mumol/l) free serum @entity6211 . @entity1 with increased serum @entity6211 showed a significantly higher mortality rate (47%) than @entity1 with normal serum @entity6211 . It is concluded that free and total serum @entity6211 are elevated in @entity1 with @entity712 , dilated and @entity1121 . The etiology of this @entity6211 metabolism disturbance is unclear but it is probably due to a secondary phenomenon in @entity1 with @entity712 or primary @entity1283 . An increased serum @entity6211 is a poor prognostic sign in @entity1 with @entity384 .
