Does fibrin glue reduce @entity2680 ( XXXX ) after extended esophagectomy? Prospective randomized clinical trial.

@entity1143 @entity1 @entity2680 @entity260 @entity1800 @entity418 @entity86
Fibrin glue has been shown to be effective in improving postoperative chylothorax following various thoracic procedures and in reducing lymphorrhea after axillary dissection. It is unknown, however, whether fibrin glue is effective in reducing @entity2680 ( @entity1143 ) after esophagectomy. A series of 43 consecutive @entity1 with @entity418 who underwent extended esophagectomy were prospectively randomized to two groups: group A (n = 21), in whom 3 ml of fibrin glue was applied to the dissected mediastinum; and group B (n = 22), in whom fibrin glue was not applied. The time of drain removal and the volume of the thoracic drainage were compared. All data were expressed as the mean +/- standard deviation. There were no significant differences in the clinicopathologic characteristics between the two groups. None of the @entity1 developed chylothorax or died during their hospital stay. The daily volume from the thoracic drain (457 +/- 273 ml) was significantly (p < 0.05) larger on postoperative day (POD) 1 in group A than in group B (298 +/- 158 ml) and tended to be larger (p < 0.10) on PODs 4 and 6 in group A than in group B. The cumulative drainage volume was significantly (p < 0.05) larger on PODs 4 to 6 and POD 9, and it tended to be larger (p < 0.10) on PODs 1, 3, 7, 8, 10, and 11 in group A than in group B, suggesting that the cumulative drainage volume in group A was consistently larger than that in group B. The cumulative numbers of @entity1 with a drain remaining in place were not significantly different for the two groups (p = 0.4683). Three @entity1 in group A, however, had prolonged insertion (> 20 days) of the chest tube. There were no significant differences in the incidence of @entity260 . No @entity1 in group A developed @entity1800 during the long-term follow-up. Application of fibrin glue to the dissected mediastinum seems to induce @entity86 and thus be responsible for prolonged chest tube insertion in some @entity1 . Hence the use of fibrin glue cannot be recommended for reducing @entity2680 after esophagectomy.
