Cor a 14: missing link in the molecular diagnosis of hazelnut XXXX ?

@entity1 @entity483 @entity566 @entity1735 @entity56
BACKGROUND: Hazelnut @entity566 shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete. METHODS: Sera of 75 @entity1 @entity56 to hazelnuts, 14 @entity1 with @entity483 ( @entity483 ) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive @entity1735 determinants (CCDs). RESULTS: Sensitization to Cor a 14 was observed in 18 out of 20 preschool @entity1 , 8 out of 10 school-aged @entity1 and 2 out of 7 adults with generalized reactions and in 3 out of 14 @entity1 with @entity483 . Only 2 out of 38 @entity1 with an @entity566 ( @entity566 ) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 @entity566 @entity1 and in 14 out of 37 @entity1 with generalized reactions. However, only 3 @entity1 with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 @entity1 with generalized reactions and in 4 out of 14 @entity1 with @entity483 . Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare. CONCLUSIONS: Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of @entity1 with generalized reactions to hazelnut.    2014 S. Karger AG, Basel.
