Expression of @entity7 ( @entity7 )-D and its receptor, XXXX 3, as a prognostic factor in @entity1204 .

@entity1204 @entity1 @entity7802 @entity7 @entity5 @entity189 @entity319 @entity9205 @entity1869 @entity3
PURPOSE: To evaluate the prognostic value of @entity7 ( @entity7 )-D and @entity319 ( @entity319 )-3 in @entity1204 . EXPERIMENTAL DESIGN: We assessed the levels of immunoreactivity for @entity9205 and @entity7802 in 71 @entity1204 , 14 complex atypical @entity1869 , and 16 normal endometria by immunohistochemistry. RESULTS: @entity9205 was stained in both @entity5 cells and adjacent stromal cells. @entity7802 was stained in both @entity5 cells and adjacent endothelial cells. Immunoreactivity for @entity9205 in @entity5 cells and adjacent stromal cells became significantly stronger as lesions progressed from normal endometrium to advanced @entity189 . Similarly, immunoreactivity for @entity7802 in @entity5 cells and adjacent endothelial cells was significantly greater as lesions progressed from normal endometrium to advanced @entity189 . A strong correlation was found between high levels of @entity9205 immunoreactivity in @entity189 cells and @entity7802 in both @entity189 cells and adjacent endothelial cells. Similarly, high levels of @entity9205 immunoreactivity in stromal cells were significantly correlated with those of @entity7802 in both @entity189 cells and endothelial cells. High levels of @entity9205 in @entity189 cells and stromal cells, as well as those of @entity7802 in @entity189 cells and endothelial cells, were significantly related to @entity3 and lymph node @entity3 . A strong correlation was found between poor survival and high levels of @entity9205 in both @entity189 cells and stromal cells and between poor survival and high levels of @entity7802 in @entity189 cells. Moreover, the high levels of @entity9205 in stromal cells and @entity7802 in @entity189 cells were independent prognostic factors in @entity1204 . CONCLUSIONS: The presence of @entity9205 and @entity7802 in @entity1204 may predict @entity3 and lymph node @entity3 and may prospectively identify @entity1 who are at increased risk for poor outcome. In addition, @entity9205 and @entity7802 may be promising targets for new therapeutic strategies in @entity1204 .
