The Janus-faced roles of @entity4059 in XXXX cells.

@entity1 @entity4059 @entity4730 @entity5 @entity957 @entity219 @entity1495
UNASSIGNED: @entity4059 ( @entity4730 ) is a @entity219 -finger transcription factor that regulates many essential processes, including development and cell differentiation, proliferation, and apoptosis. Along with these roles in normal cells and tissues, @entity4730 has important @entity5 suppressive and oncogenic functions in some @entity5 . However, the roles of @entity4730 in @entity957 remain unclear. This study investigated the epigenetic alterations and possible roles of @entity4730 in @entity5 . Notably, @entity4730 expression was significantly decreased in @entity1 @entity5 tissues compared with healthy controls, and @entity4730 promoter hypermethylation contributed to the suppression of @entity4730 expression. @entity4730 expression was associated with @entity5 grade. Its expression was much lower in poorly differentiated @entity5 than in well-differentiated @entity5 cells. @entity4730 exerted its antitumor activity in vitro and/or in vivo by inhibiting cell proliferation, cell cycle progression, cell colony formation and by inducing apoptosis. In addition, @entity4730 over-expression promoted @entity5 cell migration and invasion in vitro. Knockdown of @entity4730 promoted @entity5 cells growth and colony formation, and simultaneously inhibited cell migration and invasion. Mechanistic studies revealed that @entity1495 might contribute to @entity4730 -mediated cell migration and invasion. These results provide evidence that @entity4730 might play Janus-faced roles in @entity5 , acting both as a @entity5 suppressor and as an oncogene.
