Evaluation of telomerase activation in XXXX .

@entity5 @entity135 @entity1 @entity286
During replication of the linear chromosomes, telomeres, i.e. the ends of the chromosomes, are not replicated completely by the conventional DNA polymerases. Therefore, normal somatic cells senesce after certain number of cell divisions. Telomerase is a special reverse transcriptase used by most eukaryotes to achieve immortalization. Telomerase activity has been determined in a variety of @entity5 . However, there are few reports on telomerase activity in @entity135 . The etiology of the disease in India is completely different from Western countries. @entity286 consumption is more prevalent in India and the mode of @entity286 consumption (e.g. chewing, snuffing, bidi smoking, reverse smoking) is also different. The present study determined telomerase activity in 32 @entity5 samples of @entity135 @entity1 , 11 samples from @entity1 with precancerous/benign lesions and 30 samples of adjacent normal tissues. Telomerase was found to be activated in 80% of the @entity1 with @entity135 , 100% of the @entity1 with precancerous/benign lesions and 74% of the adjacent normal tissues. According to the theory of field cancerization, carcinogenic insults (e.g. @entity286 ) may result into multiple malignant foci. This fact may explain the reason for high telomerase positivity in adjacent normal as well as precancerous/benign tissues. Telomerase activation and the clinical or histopathological characteristics of the @entity135 @entity1 were observed to be independent features. This is a preliminary report which has generated a greater interest for in-depth elucidation of the role of telomerase and telomeres in @entity135 in India.
