Relationship between collateral blood flow and microvascular perfusion after reperfused XXXX .

@entity1 @entity296 @entity1188 @entity1562 @entity583 @entity8892
During acute occlusion of an epicardial vessel collaterals preserve the microvascular perfusion and limit the extent of @entity296 . Pressure-derived collateral flow index ( @entity8892 ) assessed by intracoronary pressure measurement allow us to quantify collateral vessel development. The angiographic @entity296 ( @entity296 ) scores, based on the contrast dye density and washout in the infarcted @entity1562 , provide important information about microvascular perfusion after @entity583 ( @entity583 ). In this study we assessed the microvascular perfusion with @entity296 and studied the relation between @entity8892 in @entity1 with @entity583 who treated with thrombolytic therapy and TIMI grade III flow restored in the @entity1188 related artery (IRA). Forty-one @entity1 with @entity583 who were treated with thrombolytic therapy and underwent stent implantation (mean of 3 days after @entity583 ) to the IRA were included in this study. After angiography, @entity8892 was calculated as the ratio of simultaneously measured coronary wedge pressure--central venous pressure (Pv) to mean aortic pressure--Pv. Myocardial blush was graded densitometrically based on visual assessment of the relative contrast opacification of the myocardial territory subtended by the @entity1188 vessel. There was a statistically significant correlation between @entity8892 and post-stent @entity296 grades (P < 0.01, r = 0.70). There was a significant difference in mean @entity8892 among @entity296 grades implying that higher @entity8892 is associated with better @entity296 (0.39 +/- 0.11 in grade 3, 0.32 +/- 0.10 in grade 2, 0.24 +/- 0.09 in grade 1, and 0.16 +/- 0.08 in grade 0, P < 0.01). Well developed collaterals can limit microvascular damage by preserving microvascular perfusion. A higher pressure-derived collateral flow index is associated with better tissue level perfusion as evidenced by the higher @entity296 score.
