XXXX : a possible cause of acute colitis.

@entity1 @entity13586 @entity548 @entity75 @entity5 @entity294 @entity262 @entity344 @entity281 @entity3840 @entity1049
Nonsteroidal antiinflammatory agents may cause relevant small bowel and colonic side effects, apart from @entity75 . The synthesis of selective @entity3840 ( @entity3840 ) inhibitors has been an important breakthrough in antiinflammatory therapy by decreasing the incidence of @entity344 . However, there is little information available concerning their effects on gut mucosa distally to the duodenum. A case history is described of a 52-year-old @entity1 with a temporary colostomy after resection of a sigmoid @entity5 and who presented with bloody @entity294 5 days after beginning therapy with @entity13586 . The @entity548 had its origin in the transverse colon, and the endoscopic appearance was that of actively @entity548 acute @entity548 . No other @entity1049 were detected, nor was there any evidence of related @entity281 , @entity548 diathesis, or other @entity262 . On discontinuing @entity13586 and instituting parenteral rehydration, the @entity548 and @entity294 stopped. Endoscopic follow-up revealed regenerating mucosa in the transverse colon. The time relation, the absence of other causes of @entity548 , and the clinical evolution all strongly support the probability of a causal relation between @entity13586 and @entity548 . This case may raise awareness concerning the possibility of @entity1049 related to the new @entity3840 inhibitors, similar to what is known about nonselective antiinflammatory agents.
