Micro-MRI at 11.7 T of a XXXX @entity1313 model using delayed contrast enhancement.

@entity5 @entity39913 @entity19 @entity1313
In vivo imaging methodologies allow for serial measurement of @entity5 size, circumventing the need for sacrificing @entity19 at given time points. In orthotopically transplanted @entity19 models of @entity1313 , cross-section micro-MRI allows for visualization and measurement of the physically inaccessible @entity5 . To allow for long resident times of a contrast agent in the @entity5 , intraperitoneal administration was used as a route of injection for contrast-enhanced micro-MRI, and a simple method for relative @entity5 volume measurements was examined. A strategy for visualizing the variability of the delayed @entity5 enhancement was developed. These strategies were applied to monitor the growth of @entity1313 xenotransplanted into @entity19 and either treated with the antiangiogenic peptide @entity39913 or an inactive control peptide. Each @entity19 was used as its own control. Serial imaging was done weekly, beginning at Day 7 after @entity5 cell implantation and continued for 7 weeks. Images obtained were reconstructed on the MRI instrument. The image files were transferred off line to be postprocessed to assess @entity5 growth (volume) and variability in enhancement (three-dimensional [3-D] intensity models). In a small study, @entity5 growth and response to treatment were followed using this methodology and the high-resolution images displayed in 3-D allowed for straightforward qualitative assessment of variable enhancement related to vascular factors and @entity5 age.
