XXXX in childhood: clinical study and therapeutic results in 22 cases.

@entity1 @entity1143 @entity632 @entity5 @entity229 @entity786 @entity14361 @entity11770 @entity34899 @entity1897 @entity1891 @entity490 @entity1732 @entity5538 @entity5713
Twenty-two @entity1 with @entity5 ranging in age from 2 to 13 1/2 years are described. In 10 cases, the correct diagnosis was only made retrospectively. The most salient pathologic features were found in lymph node biopsy specimens. Fever and wasting were the most prominent symptoms in 21 cases, and @entity490 were striking in 9. @entity1897 , mostly of the cervicoaxillary type, was present in 21 @entity1 , with marked tenderness in 14. Abnormal mediastinal and/or paraaortic lymph nodes were detected radiographically in two-thirds of the @entity1 . Other prominent features included subcutaneous inflammatory infiltration in 12 @entity1 and skin nodules in 8. @entity1143 were seen in 8 @entity1 . The haematologic findings are described. Only 5 of 19 @entity1 had @entity14361 . Fifteen @entity1 died, one to 45 months from onset of their illness (median survival time, five months). Nine @entity1 are alive with no evidence of disease 21 to 46+ months (median, 40 months) after the time of diagnosis and 8 have currently been off treatment for periods ranging from three to 29 months; they all have been treated with @entity1891 , @entity229 , @entity786 , and @entity632 and 4 have achieved remission after treatment with @entity5713 , @entity1732 , and @entity11770 or @entity5538 - @entity34899 . It is concluded from this study that clearly delineated clinical features of @entity5 in childhood should allow more rapid determination of the proper diagnosis and should result in early treatment by means of intensive systemic combination chemotherapy, which has dramatically improved the prognosis.
