Two distinct types of XXXX -binding protein are expressed in heart ventricle of Antarctic teleost fishes.

@entity1 @entity844 @entity9318 @entity535 @entity9319
This report provides the first evidence for the existence of two distinct types of @entity844 -binding protein (FABP) in cardiac tissue of vertebrates. Four species of Antarctic teleost fish ( @entity9319 , Cryodraco antarcticus, Gobionotothen gibberifrons and @entity9318 ) exhibited two FABP mRNAs of 1. 0 kb and 0.8 kb, which we have termed Hh-FABP and Had-FABP (isolated from Heart tissue, with similarity to @entity1 heart-type FABP or @entity1 adipose-type FABP respectively). These FABP types appear to be products of distinct genes. Both FABP transcripts were abundant in cardiac and aerobic pectoral muscle. However, relative abundance of the two types varied distinctly among other tissues such as kidney, brain, spleen and white muscle. Neither FABP type was expressed in liver or intestine. The coding regions of Hh-FABP and Had-FABP cDNAs from the same species are only approximately 60% identical with one another. However, homologues of each FABP species, which exhibit >98% identity to their respective types, were isolated from three other Antarctic teleosts. Phylogenetic analysis of aligned @entity535 sequences places Hh-FABP with other vertebrate heart-type FABPs, and Had with adipose/cutaneous FABPs. Expression of two distinct FABPs in cardiac tissue of Antarctic teleosts may be related to their ability to both utilize @entity844 as the primary metabolic fuel and to store lipid intracellularly.
