Regional differences in XXXX and in vitro contractility after outlet obstruction in the @entity95 .

@entity1494 @entity4338 @entity95 @entity1876 @entity5402 @entity855
PURPOSE: @entity1876 leads to @entity1494 and subsequent decreases in contractile function in vivo and in vitro. We determined whether there were regional differences in bladder wall properties and in vitro contractile responses after 2 weeks of @entity1876 . MATERIALS AND METHODS: Male @entity95 underwent cystometry. The bladder was then filled to 40 ml. and the surface was marked with 2-zero silk knots placed approximately 1 cm. apart. The distance between the knots was measured at 20, 40 and 80 ml. The animals then underwent the creation of surgical obstruction. After 2 weeks the obstruction was removed. Cystometry and measurements were repeated and strips were obtained from defined dorsal and ventral areas. Contractile responses to electrical field stimulation, @entity855 , @entity5402 and @entity4338 were determined and compared with strips from unobstructed controls. RESULTS: In vivo expansion during @entity1494 occurred evenly throughout the bladder wall in controls and the contractile response to all stimuli was similar in ventral and dorsal strips. After 2 weeks of @entity1876 the upper dome expanded to a significantly higher degree than the lower bladder body. The response to all stimuli was significantly reduced after @entity1876 and there was a significantly decreased response to all stimuli in dorsal compared with ventral strips. Strips from the dorsal midline showed a relaxation response to electrical field stimulation at low frequencies, whereas all ventral strips contracted. CONCLUSIONS: Functional remodeling after @entity1876 is a process that does not occur to the same extent throughout the bladder. The obstructed bladder is an inhomogeneous organ with significant regional differences in mechanical and pharmacological properties.
