Positron emission mammography in the diagnosis of XXXX . Is maximum PEM uptake value a valuable threshold for malignant @entity0 detection?

@entity1 @entity0 @entity189 @entity5
AIM: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). @entity1 , METHODS: In a singlesite, non-interventional study, 108 @entity1 (107 @entity1 , 1 @entity1 ) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq 18F-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, @entity5 (PUVmaxtumour), benign lesions (PUVmaxnormal breast) and also in healthy tissues on the contralateral side (PUVmaxcontralateral breast). These values were compared and contrasted. In addition, the ratios of PUVmaxtumour   /   PUVmaxcontralateral breast and PUVmaxnormal breast   /   PUVmaxcontralateral breast were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected @entity189 . RESULTS: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the @entity1 cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78    2.47 was identified in @entity5 , while a mean PUVmaxnormal breast of 1.17    0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between @entity5 and healthy glandular tissue in @entity0 @entity1 (3.15    1.58) was found to be significantly higher than the ratio for benign lesions (1.17    0.41, p < 0.001). CONCLUSION: PEM is capable of differentiating @entity0 from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.
