[Combination chemotherapy and radiation therapy for small cell XXXX ].

@entity1 @entity632 @entity66 @entity5 @entity75 @entity2 @entity786 @entity1891
From January, 1982 to March, 1983, @entity1 with small cell @entity2 were treated at Kyushu @entity5 Center. Eleven @entity1 received combination chemotherapy-radiotherapy and one @entity1 chemotherapy alone. The chemotherapy regimen consisted of @entity786 , @entity632 and @entity1891 which was repeated every 4 weeks for as long as possible. Radiotherapy was administered to the @entity75 and mediastinum following 2 cycles of induction chemotherapy. The overall response rate after receiving 2 cycles of chemotherapy was 75% with 4 complete (33%) and 5 partial responses (42%). After radiotherapy, response increased to 100% with 8 complete (73%) and 3 partial responses (27%). Complete response occurred in 6 of the 7 @entity1 with limited disease and 2 of the 5 @entity1 with @entity66 . Overall survival rate was 73% at 1 year, 36% at 2 years and 12% at 3 years with a median survival time of 21 months. Survival was better in @entity1 with limited disease than in those with @entity66 (median survival time, 21.5 months vs. 14 months). In the 3-Year follow-up period, all @entity1 had recurrences consisting of 4 distant, 2 local and 5 both. Myelosuppression was mild to moderate and there were no deaths related to the side effects of treatment.
