Actions of some vasodilators on isolated XXXX hand veins.

@entity1 @entity141 @entity1854 @entity3931 @entity3303 @entity3302 @entity750 @entity972 @entity3774 @entity2553 @entity1063
@entity2553 is a well recognized complication during microvascular surgery of the hand. In the search for new spasmolytic drug therapies, the effects of @entity3302 , @entity1854 , @entity3931 and @entity3303 on isolated @entity1 hand veins contracted by several postulated mediators of @entity2553 were examined. Mechanical activity was recorded isometrically in ring segments of the vessels. @entity972 ions, @entity1063 (NA), @entity750 ( @entity750 ) and @entity3774 (PGF2 alpha) all produced strong contractions that were highly dependent on the presence of extracellular @entity141 . @entity3302 acted as a nonselective vasodilator, as it produced an almost identical inhibition of contractile responses to all examined stimulants. @entity1854 inhibited contractions induced by agonists more than those evoked by K+, whereas the opposite was found for @entity3931 . @entity1854 also seemed to display a certain degree of selectivity among the agonist-induced responses (NA greater than PGF2 alpha greater than @entity750 ). @entity3303 increased the contractile response to K+ and at high concentrations (greater than 10(-5) M) produced a contraction per se. The clinical efficacy of @entity3303 as a vasodilator after topical application therefore seems to reflect an inhibitory action on vasoconstrictor nerves. @entity3302 , @entity1854 , @entity3931 and @entity3303 differ considerably in their profiles of action and therefore deserve to be further evaluated in the treatment of @entity2553 during microvascular surgery.
