Differences in breathing patterning during wakefulness in XXXX with mixed @entity27 .

@entity1 @entity387 @entity27 @entity18130 @entity386
BACKGROUND: Mixed @entity386 share both central and obstructive components and are often treated as if they are obstructive events. The hypothesis is that @entity1 with @entity27 ( @entity18130 ) who exhibit a majority of mixed @entity386 will differ in ventilatory control from those with predominantly obstructive @entity386 during wakefulness; moreover, this difference could affect nasal continuous positive airway pressure (CPAP) adherence. METHODS: In a retrospectively derived case-control study, 5 min of respiratory inductance plethysmography signals during wakefulness prior to sleep onset were extracted from a diagnostic polysomnogram in these groups: (1) mixed @entity386 -dominant @entity18130 (mix- @entity18130 ) (n = 36), (2) obstructive @entity386 -dominant @entity18130 ( @entity18130 ) (n = 20), (3) central @entity387 (pure-CSAS) (n = 6), and (4) control subjects (n = 10). Breathing patterning was compared between the groups using the coefficient of variation (CV) for breath-to-breath inspiration time (TI), expiration time (TE), TI + TE (Ttot), and tidal volume, and an information theory-based metric of signal pattern variability (sample entropy). Subsequent CPAP adherence over 12 months was determined in @entity18130 groups. RESULTS: Breath-to-breath CV parameters and sample entropy in the mix- @entity18130 group were significantly greater as compared with the @entity18130 and control groups. In a subanalysis, CV and sample entropy were similar in the mix- @entity18130 and the pure-CSAS groups. CPAP adherence was significantly poorer in mix- @entity18130 compared with @entity18130 . CONCLUSIONS: During wakefulness, both breath patterning and sample entropy in mix- @entity18130 are similar to pure-CSAS and more variable than in @entity18130 . In addition, CPAP adherence was decreased in @entity1 with mix- @entity18130 , which may be related to basic differences in respiratory control.
