XXXX and E supplementation does not reduce the risk of superimposed PE in pregnancy.

@entity1 @entity101 @entity270 @entity620 @entity1468 @entity4793
BACKGROUND: Oxidative stress could play a role in the development of @entity1468 . There is some evidence to suggest that @entity620 and E supplements can reduce the risk of the disorder. We hypothesized its beneficial role in a group of pregnant @entity1 with essential @entity101 . METHODS: In this randomized controlled trial, we enrolled 50 pregnant @entity1 with essential @entity101 . We assigned the @entity1 1000 mg @entity620 and 400 IU natural @entity270 (RRR a @entity4793 ; n = 25), daily from the second trimester of pregnancy until delivery or no supplementation (n = 25). Our primary endpoint was development of superimposed @entity1468 , and main secondary endpoints were aggravation of @entity101 , need for admission, need to increase antihypertensive drugs, and small size for gestational age (<fifth customized birthweight centile). RESULTS: We analyzed 50 @entity1 who completed the study. The incidence of superimposed @entity1468 was similar in vitamin and control groups (8% [n = 2] vs 12% [n = 3], p = 1.000). @entity620 and E supplementation also did not prevent aggravation of @entity101 in group of @entity1 who took it (12% [n = 3] vs 32% [n = 8], p = 0.172). Small size for gestational age babies did not differ between groups (4% [n = 2] vs 6% [n = 3], p = 1.000). CONCLUSION: @entity620 and E supplementation does not prevent development of superimposed @entity1468 in @entity1 with essential @entity101 . Our results did not show any significant benefit of vitamin supplementation. There was some trend in lessening of @entity101 complications of pregnancy. Our results failed to find any correlation between development of superimposed @entity1468 and oxidative stress.
