Role of sample adequacy in XXXX of palpable @entity1558 .

@entity1 @entity5 @entity2286 @entity400 @entity1558
BACKGROUND: The role of @entity400 ( @entity400 ) in @entity1558 remains uncertain because its accuracy has been questioned. We hypothesized that this is related to failure to define standards for adequacy of sample preparation. METHODS: We reviewed cytology and pathology reports from 351 @entity1 undergoing @entity400 at a 350-bed community, university-affiliated teaching hospital over a 2-year period. @entity1 were included if they had an open biopsy within 2 years of an @entity400 of the same lesion. Cytology reports were reviewed by a cytopathologist unaware of the clinical setting or subsequent histology; surgeons unaware of the cytology reports reviewed histology reports. Cytological diagnoses were benign, likely benign, probable @entity5 , and definite @entity5 . Samples were characterized as satisfactory, less than optimal (few mammary epithelial clusters), or inadequate (no mammary epithelial clusters.) We assessed the proportion of inadequate samples, the accuracy of @entity400 , and the influence of sample adequacy upon @entity400 sensitivity. RESULTS: Ninety-nine (28%) FNABs were inadequate, 77 (22%) less than optimal, and 175 (50%) satisfactory. Ninety-five @entity1 (27%) had a final diagnosis of @entity5 . FNABs classified as satisfactory or less than optimal and characterized as benign (n = 102) had a negative predictive value (NPV) of 0.91; those termed definite @entity5 (n = 43) had a positive predictive value ( @entity2286 ) of 0.98. Only 10% of all @entity5 were identified in the 28% of FNABs that were classified as inadequate (P <0.01). CONCLUSIONS: We concluded that too few FNABs are performed in a fashion that permits definitive cytological interpretation. Inadequate FNABs are less likely to detect @entity5 . After excluding inadequate preparations, FNABs interpreted as definite @entity5 and as benign are highly accurate in identifying @entity1 with and without @entity5 .
