Health-related quality of life in 640 XXXX survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H_N35 questionnaires.

@entity1 @entity135 @entity283 @entity5 @entity2133
BACKGROUND: With the advances in modern radiotherapy (RT), many @entity1 with @entity135 ( @entity135 ) can be effectively cured, and their @entity283 ( @entity283 ) has become an important issue. In this study, we evaluated the prognosticators of @entity283 in a large cohort of @entity135 @entity1 , with a focus on the result from technological advances in RT. METHODS: A cross-sectional investigation was conducted to assess the @entity283 of 640 @entity135 @entity1 with @entity5 -free survival of more than 2 years. Among them, 371 @entity1 were treated by two-dimensional RT (2DRT), 127 by three-dimensional conformal RT (3DCRT), and 142 by intensity-modulated RT (IMRT). The EORTC QLQ-C30 questionnaire and QLQ-H_N35 module were used. A general linear model multivariate analysis of variance was used to analyze the prognosticators of @entity283 . RESULTS: By multivariate analysis, the variables of gender, annual family income, @entity5 site, AJCC stage, treatment methods, and RT technique were prognosticators for QLQ-C30 results, so were @entity5 site and RT technique for H_N35. Significant difference (p < 0.05) of @entity283 outcome by different RT techniques was observed at 2 of the 15 scales in QLQ-C30 and 10 of the 13 scales in H_N35. Compared with 2DRT, IMRT had significant better outcome in the scales of global QoL, physical functioning, swallowing, senses (taste/smell), speech, social eating, social contact, teeth, @entity2133 , @entity2133 , sticky saliva, and feeling ill. CONCLUSIONS: The technological advance of RT substantially improves the head-and-neck related symptoms and broad aspects of @entity283 for @entity135 survivors.
