[Assessment of the optimization of the conditions of @entity1138 intravesical instillation completion in the setting of non-muscle invasive XXXX treatment].

@entity1 @entity1139 @entity1138 @entity150
OBJECTIVE: The efficacy of intravesical instillation of @entity1138 ( @entity1139 ) requires alkalinisation and concentration of urine before each instillation. The objective of the study was to assess compliance and effectiveness of urine alkalinazation and fluid restriction protocols in @entity1 treated with intravesical instillations of @entity1139 for TVNIM. MATERIAL ET METHOD: Descriptive prospective epidemiological study in all @entity1 consecutively treated with intravesical instillations of @entity1139 for non-muscle invasive @entity150 (NMIBC). @entity1 should be advised to drink 2  liters of water from Vichy and to perform fluid restriction the day before the instillations. Before each instillation, a questionnaire on the implementation of these measures was filled, density and pH were determined by urinalysis strips. RESULTS: On 126  questionnaires fulfilled, 117  @entity1 (93%) and 106  @entity1 (84%) reported having made alkalinization and fluid restriction, respectively. Ninety-one of @entity1 (78%) reported having performed alkalinization had a pH greater than or equal to 6.5  and the mean urinary pH was 6.94  vs. 5.94  in @entity1 stating not to have made alkalizing (P=0.0001). No significant differences in urine density according to fluid restriction was found. CONCLUSION: The observance of the instructions regarding urine alkalinization before @entity1139 instillations was satisfactory and has achieved a sufficiently high urinary pH to prevent degradation of the product in 91% of cases. Conversely, the fluid restriction was not followed closely and has not shown its effectiveness on the concentration of urine. LEVEL OF EVIDENCE: 4.
