Preserved fetal plasma XXXX concentrations in the presence of maternal hypoaminoacidemia.

@entity1522 @entity17691 @entity1160 @entity535 @entity3793 @entity2734 @entity1592 @entity2340 @entity815 @entity1017 @entity35 @entity1889 @entity669 @entity493 @entity413
The effects on the conceptus of persistently decreased maternal plasma @entity535 concentrations were studied in pregnant @entity35 by the infusion of glucagon (0.21 mg/day) to the mother from day 14 to 20 of gestation with a subcutaneous, osmotically driven minipump. Controls received diluent. The experimental animals either had normal caloric intake and @entity1017 , or diminished caloric intake with no @entity1017 . Both experimental groups exhibited a decrease in plasma total @entity535 concentration of approximately 50%. Maternal plasma @entity413 and insulin concentrations were unaffected except for slight decreases in the low @entity1017 group. At cesarean section on day 20, fetal weight was unaffected in the normal @entity1017 group, while the low @entity1017 animals exhibited @entity1592 . Fetal plasma @entity413 and insulin concentrations were unaffected. Despite the marked decrease in maternal plasma total @entity535 concentration, fetal plasma total @entity535 concentration was unaffected. Individual plasma @entity535 concentrations in the normal @entity1017 mothers and fetuses revealed a spectrum of changes. Some maternal @entity1522 were decreased by more than 60% ( @entity17691 , @entity2734 , @entity1889 , @entity1160 , @entity493 ) while others were unaffected ( @entity669 , @entity2340 , @entity815 , @entity3793 ). In general, @entity1522 that were decreased in the mother exhibited no change or a lesser decrease in fetal plasma concentration, while those that were unaffected in the mothers showed increased fetal concentrations. Fetuses from the low @entity1017 mothers had plasma @entity535 profiles that were similar to those of the normal @entity1017 mothers.(ABSTRACT TRUNCATED AT 250 WORDS)
