Acute XXXX and @entity1578 as the first manifestations of @entity2360 .

@entity1 @entity82 @entity390 @entity548 @entity879 @entity4 @entity409 @entity391 @entity2361 @entity425 @entity772 @entity1578 @entity3521 @entity2360 @entity920 @entity490 @entity2142 @entity10 @entity221
@entity879 and @entity2142 appeared quite suddenly as the first manifestations of @entity2360 ( @entity2360 ) in five of our @entity1 previously regarded as healthy @entity1 (although an interview showed that 2-4 weeks prior to the illness the @entity1 complained of several non-specific symptoms, such as @entity490 , @entity10 , @entity221 , @entity425 or behavioural changes). All the @entity1 were young @entity1 (17-23 years), none of them had any history of @entity409 . They were admitted with icterus, @entity390 , @entity391 and symptoms of increasing haemolysis. The diagnosis of @entity2360 was given as disturbed @entity920 metabolism. After a short period of observation ascites and @entity4 occurred, @entity548 and other symptoms of @entity1578 increased. Levels of clotting factors decreased rapidly. Despite treatment with @entity2361 , plasmapheresis, and symptomatic drugs, three of the @entity1 died in irreversible liver @entity772 , due to the unavailability of liver transplantation. The fourth @entity1 was carried to the Transplantation Centre, due to aggravation of the symptoms of @entity1578 , where liver transplantation was performed. Histopathologically micronodular @entity82 was shown in all these cases. The fifth @entity1 survived having undergone the above treatment without liver transplantation. The main differences between the @entity1 who survived and those who died or underwent transplantation were relatively higher activity of alkaline phosphatase (26 U/l vs. 10-20 U/l), slightly higher levels of clotting factors and prothrombin time, which never fall below 68% of the control (versus 14-44% in other @entity1 ). Only in the surviving @entity1 was the @entity3521 present. In four of our @entity1 we found family members who were carriers of @entity2360 .
