Effect of @entity1242 and @entity5018 on left ventricular topography and @entity397 threshold during healing after myocardial infarction in the XXXX .

@entity3763 @entity1242 @entity235 @entity5018 @entity397 @entity1188 @entity720
The effect of @entity1242 and @entity5018 , given between 2 and 7 days after left anterior descending coronary artery ligation, on the mechanical resistance of the infarcted left ventricle to @entity397 or the @entity397 threshold (balloon technique), and on topography (computerized planimetry) and function (two-dimensional echocardiography) at 7 days (n = 32) and 42 days (n = 34) postligation was studied in 66 @entity235 randomly allocated to sham (no @entity1188 , n = 22) and @entity1188 subgroups (15 controls; 15 received @entity1242 , 30 mg oral @entity3763 b.i.d.; 14 received @entity5018 , 200 mg t.i.d. orally). @entity1242 decreased mean arterial and left atrial pressures, decreased diastolic cross-sectional area, and improved systolic function, while @entity5018 increased diastolic area. @entity1188 subgroups showed @entity1188 shrinkage and more @entity1188 @entity720 at 6 weeks. Compared with shams, all @entity1188 subgroups showed early expansion and thinning, with further marked late thinning in controls. @entity1242 produced less expansion and thinning both at 1 and 6 weeks, while @entity5018 produced marked early thinning. Rupture threshold was less at 6 weeks than 1 week with controls and @entity5018 but remained unchanged with @entity1242 . Passive prerupture stiffness was less at 6 weeks than at 1 week in controls but remained unchanged with @entity1242 and @entity5018 . Thus, reduced expansion and thinning with @entity1242 during the first week after @entity1188 improved function, mechanical strength, and resistance to distension at 6 weeks.
