Organ Preference of Cancer @entity3 and XXXX -Related Cell Adhesion Molecules Including Carbohydrates.

@entity1 @entity706 @entity5 @entity1466 @entity1735 @entity1778 @entity3 @entity35 @entity157
UNASSIGNED: This review starts on one of our special interests, the organ preference of @entity3 . We examined data on 1,117 autopsy cases and found that the organ distribution of @entity3 of @entity5 of the lung, pancreas, stomach, colon, rectum, uterine cervix, liver, bile duct, and esophagus involved the lung, liver, adrenal gland, bone/bone marrow, lymph node, and pleura/peritoneum. Cancers of the kidney, thyroid, ovary, @entity1466 , and breast, however, manifested different metastatic patterns. The distribution of @entity1778 and @entity706 metastases was quite different from that of @entity5 . On the basis of experimental studies, we believe that the anatomical-mechanical hypothesis should be replaced by the microinjury hypothesis, which suggests that tissue microinjury induced by temporal @entity5 cell embolization is crucial for successful @entity3 . This hypothesis may actually reflect the so-called inflammatory oncotaxis concept. To clarify the mechanisms underlying @entity3 , we developed an experimental model system of a @entity35 @entity157 AH7974 that embraced substrate adhesiveness. This model did not prove a relationship between substrate-adhesion potential and metastatic lung-colonizing potential of @entity5 cells, but metastatic potential was correlated with the expression of the laminin @entity1735 that was recognized by Griffonia (Bandeiraea) simplicifolia isolectin G4. Therefore, we investigated the relationship between @entity1735 expression profiles and @entity3 and prognosis. We indeed found an intimate relationship between the @entity1735 expression of @entity5 cells and the progression of @entity5 , organ preference of @entity3 , metastatic potential of @entity5 cells, and prognosis of @entity1 .
