Atypical XXXX " of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases.

@entity1 @entity75 @entity5 @entity19 @entity11953 @entity3 @entity1821
@entity1821 are extremely rare in the skin. When they involve the skin, it is usually by upward spread from a subcutaneous or deeper seated @entity1821 . Very rarely, @entity1821 @entity3 to the skin or arise as a primary @entity75 . We describe 2 cases of atypical @entity5 "well-differentiated @entity1821 " located in dermis. Both presented clinically as a skin tag. The @entity5 arose in a 56-year-old female and a 69-year-old male @entity1 . Both lesions were treated by excision and reexcision. In addition to classical morphology of atypical @entity5 with evidence of lipoblasts and atypical adipocytes, immunohistochemistry with nuclear @entity19 double-minute type 2 protein and @entity11953 expression as well as fluorescence in situ hybridization analysis showing an amplification of @entity19 double-minute type 2 protein and @entity11953 were helpful to establish the diagnosis. None of the cases recurred after surgical treatment. These 2 cases show the importance of not to misdiagnose lesions which clinically may appear to be benign.
