Cortical mapping of visceral pain in XXXX with GI disorders using functional magnetic resonance imaging.

@entity1 @entity1944 @entity558 @entity29 @entity661 @entity158 @entity1744
OBJECTIVE: We sought to identify central loci that activate in response to visceral stimuli (stool and @entity158 ). We had a particular interest in observing the anterior cingulate gyrus and frontal cortex in normals and in @entity1 with @entity1944 , including @entity29 ( @entity29 ) and @entity1744 ( @entity1744 ). METHODS: Subjects underwent @entity661 to a sensation of stool and to a sensation of @entity158 while undergoing blood oxygenation level-dependent functional magnetic resonance imaging. Experiments were conducted in a Magnex 3.0-T whole body magnet with a Bruker Biospec console and a quadrature head coil. Four contiguous 5.0-mm oblique axial slices designed to optimize coverage of areas believed to be responsive to noxious stimulation were acquired. Activations were detected by using cross-correlation maps (p < 0.001) for individual subjects. The experimental groups were compared using both an analysis of variance and profile analysis. RESULTS: A significantly higher percentage of pixels activated in the anterior cingulate gyrus over both @entity158 and stool conditions for the control group than for the @entity1744 group and for the @entity1744 group than for the @entity29 group (p < 0.035). Deactivation of left somatosensory cortex was greater for the @entity1744 group than for the @entity29 group and greater for the @entity29 group than for the controls (p < 0.0065) in the @entity558 . Frontal deactivation in controls compared with disease groups bordered on statistical significance. Profile analysis of the three groups across six regions of interest revealed that the control and @entity29 groups were distinguished by different profiles of response (p < 0.005). Nonparametric evaluation of the data suggests that, among the pixels in the anterior cingulate activating to @entity158 , there are two patterns of response to @entity158 -on/off and graded. This was true for both controls and disease groups. CONCLUSIONS: Normal controls and subjects with @entity29 and @entity1744 share similar loci of activations to visceral sensations of stool and @entity158 . Both activation and deactivation of particular regions of interest differentiate the three groups, as do profiles of patterned response across six of the regions of interest for the control and @entity29 groups.
