The effect of hypertonic fluid resuscitation on @entity2657 in @entity95 subjected to brain injury and XXXX .

@entity2657 @entity548 @entity428 @entity75 @entity1219 @entity95 @entity11339
Small-volume resuscitation with 7.2% @entity1219 /10% dextran 60 ( @entity11339 ) restores cardiovascular stability faster than all other therapeutic modalities currently known. This study was undertaken to elucidate the effects of @entity11339 on the brain, specifically on the formation of posttraumatic @entity2657 . @entity11339 was administered to anesthetized albino @entity95 with or without a focal cryogenic @entity75 and @entity548 . Specific gravity of small tissue samples was determined 4 h after injury and values were topographically assembled to form a color-coded map of both hemispheres, allowing for a high resolution mapping of @entity2657 . Cerebral blood flow on the side of the lesion, as assessed by the H2 clearance method, increased transiently after injury but remained unchanged from baseline during shock and after infusion of @entity11339 , indicating intact cerebrovascular autoregulation. The cryogenic lesion without subsequent @entity11339 infusion resulted in significant @entity2657 formation in grey and white matter of the exposed hemisphere. In injured animals, resuscitation with @entity11339 led to a global reduction of brain water content in both hemispheres. We conclude that small-volume resuscitation with @entity11339 does not worsen posttraumatic @entity2657 . To the contrary, our results show that it decreases cerebral water content even in regions close to the injury. This makes it worthwhile to investigate the benefits of @entity11339 for the treatment of @entity428 .
