Orthostatic Blood Pressure Changes and Subclinical Markers of XXXX .

@entity1 @entity24022 @entity122 @entity1674 @entity13519 @entity1011 @entity731 @entity551 @entity121 @entity413 @entity165
BACKGROUND: Using a simple standing-up test in normotensive subjects, we evaluated orthostatic upright postural blood pressure (BP) changes and autonomic nervous function, as well as the relationship between orthostatic BP changes and subclinical markers of @entity731 . METHODS: A total of 515 normotensive subjects aged 35-75 years (58.4  10.0 years) were enrolled. We measured body mass index (BMI), @entity13519 (DBP), serum lipids, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hs-CRP), and urinary albumin-to- @entity1011 ratio. Brachial to ankle pulse wave velocity (baPWV) and carotid mean @entity121 ( @entity121 ) were measured. @entity1 underwent a simple standing-up test involving sitting then standing for 2 minutes each, followed again by sitting. To evaluate autonomic fluctuations, we calculated the coefficient of variation of the R-R interval, the ratio of low to high frequency heart rate variability (LF/HF), and the coefficient of component variance of high frequency. RESULTS: @entity13519 and DBP decreased when standing, with a reduction of @entity13519 when changing position of -8.0  10.2mm Hg. @entity551 ( @entity551 ) produced a significantly higher @entity13519 than without @entity551 . The baPWV was significantly higher in @entity551 than in without @entity551 . Stepwise regression analysis adjusted for age, sex, BMI, baseline @entity13519 , @entity1674 , high-density lipoprotein @entity165 , low-density lipoprotein @entity165 , fasting @entity413 , HbA1c, hs-CRP, @entity121 , late systolic peak of the pressure wave form ( @entity24022 ), and baPWV confirmed that baPWV, @entity24022 , and @entity1674 were independently related to orthostatic BP changes. Multiple regression analyses showed that a decrease in @entity13519 as well as baseline @entity13519 , age, BMI, and fasting @entity413 were independent determinants of @entity122 . CONCLUSIONS: We have shown that increased arterial stiffness was associated with @entity551 during a standing-up test. Arterial stiffness may contribute to greater BP responses to postural changes from standing.
