Herniated XXXX -associated periradicular @entity82 and @entity455 occur without @entity32 .

@entity1 @entity32 @entity455 @entity82 @entity63 @entity2295 @entity615 @entity854 @entity1274 @entity3181 @entity715 @entity1798 @entity1118 @entity2880
STUDY DESIGN: Prospective histologic comparison of perineural tissues from @entity1 requiring decompression surgery for herniated @entity1798 with those from cadaveric controls. OBJECTIVES: To examine the significance of herniated intervertebral-disc-associated perineural vascular and @entity854 with respect to @entity615 symptom generation. SUMMARY OF BACKGROUND DATA: Previous cadaveric studies have demonstrated perineural @entity455 , dilatation, and @entity715 and perineural and intraneural @entity82 occurring in association with herniated @entity1798 . It was suggested that these @entity1274 were the result of @entity63 , due to @entity3181 , and also represented a possible cause of ongoing @entity615 . Criticisms of such a conclusion arose, however, because the possibility could not be excluded that these abnormalities were the result of postmortem artifact. METHODS: Histologic and immunohistochemical comparison of discal and peridiscal tissues removed from 11 @entity1 with radiographically proven herniated @entity1798 requiring decompressive surgery and from 6 fresh cadavers without history of @entity615 in life. RESULTS: Histology and immunohistochemistry of perineural and extraneural tissues from @entity1 revealed @entity455 , @entity2295 , and endothelial abnormalities including luminal platelet adhesion, in association with @entity2880 factor levels, together with perivascular and perineural @entity82 . Elevated fibrogenic cytokine concentrations were also detected in @entity1 ' tissues. These changes occurred without evidence of @entity32 and were absent in cadaveric control tissues. CONCLUSIONS: The @entity455 detected in @entity1 may represent an important etiopathologic factor predisposing to intraneural and perineural @entity82 , and hence to @entity1118 symptoms, after disc herniation. It seems important to preserve the perineural microcirculation following disc herniation.
