Mixed bone marrow or mixed stem cell transplantation for prevention or treatment of lupus-like diseases in XXXX .

@entity583 @entity706 @entity301 @entity19 @entity2150 @entity3458 @entity9957 @entity1778 @entity1200 @entity465 @entity74 @entity3039 @entity631 @entity792 @entity2395 @entity2246
Scientific analyses fortified by interpretations of @entity1200 as 'experiments of nature' have revealed the specific immune systems to be comprised of T cells subserving cell-mediated immunities plus B cells and plasma cells which produce and secrete antibodies. These two separate cellular systems regularly interact with each other to produce a coordinated defense which permits mammals to live within a sea of microorganisms that threaten the integrity and the survival of individuals. We have shown that bone marrow transplantation (BMT) can be used as a form of cellular engineering to construct or reconstruct the immune systems and cure otherwise fatal severe combined @entity465 . When severe @entity2150 complicated the first BMT which was performed to cure a fatal severe combined @entity465 , a second BMT cured for the first time a complicating severe @entity2150 . Subsequently, BMT has been used effectively to treat some 75 otherwise fatal diseases such as @entity1778 , @entity706 , @entity2246 , and @entity74 of the hematopoietic development such as @entity3458 , @entity2395 , @entity9957 , and many other diseases. More recently, we have employed BMT in @entity19 both to cure and cause @entity792 , and, together, these experiments showed that @entity792 actually reside in the hematopoietic stem cells. We have also found that mixed BMT or mixed hematopoietic stem cell transplantation (HSCT) can be used to prevent and cure the most complex @entity792 such as those occurring in BXSB @entity19 and in (NZW x BXSB)F1 W/BF1 @entity19 . Untreated, the former develop fulminating lethal @entity631 plus numerous humoral @entity792 . @entity19 of the (W/B)F1 strain develop @entity3039 , @entity301 with @entity583 , @entity631 , and numerous autoantibodies. All of these abnormalities are prevented or cured by mixed syngeneic (autoimmune) plus allogeneic (normal healthy) BMT or mixed peripheral blood HSCT. Thus, the most complex @entity792 can be prevented or cured in experimental animals by mixed syngeneic plus allogeneic BMT or HSCT which produce stable mixed chimerism as a form of cellular engineering.
