Increasing maternal body mass index during pregnancy increases neonatal intensive care unit admission in near and full-term XXXX .

@entity1 @entity101 @entity6 @entity28 @entity4053 @entity1468
BACKGROUND: Obesity is becoming an increasingly commonplace health problem. Obesity during pregnancy is important because the condition adversely affects not only the mother, but also the developing fetus and the newborn. OBJECTIVE: The primary objective of this study was to evaluate the association between maternal body mass index (mBMI) at the time of delivery and neonatal intensive care unit (NICU) admission of offspring and to analyze the role of possible confounding variables that are often associated with @entity28 . Comorbidities, such as @entity6 ( @entity6 ), @entity101 ( @entity101 ) and/or @entity1468 ( @entity1468 ), are more common in more @entity28 mothers, as is a higher association of @entity28 among non-Caucasian @entity1 . METHODS: Using a retrospective cohort design, 1736 mothers and their singleton live-born at      >= 35 weeks' gestation were analyzed for mBMI, maternal conditions of @entity6 , @entity101 and/or @entity1468 , and whether NICU care was required and the reason for NICU admission. RESULTS: NICU admission rate was significantly associated with maternal @entity28 . In comparing @entity1 with mBMI      <   30 versus mBMI   >=    30, OR was 1.39 (p   =   0.045); OR increased to 1.76 (p   =   0.006) in comparing @entity1 with mBMI    >=    35. mBMI was significantly associated with an increased rate of maternal @entity6 , @entity101 and @entity1468 (p   <   0.05 each); however, NICU admission rate was not correlated with @entity6 , @entity101 or @entity1468 . The relationship between NICU admission and mBMI was significant in Caucasian mothers versus a borderline significance in African-American mothers (p   =   0.035 versus p   =   0.05). After controlling for @entity4053 ( @entity4053 ) as the reason for admission to the NICU, no mBMI-NICU association persisted. The rate of @entity1 with @entity4053 increased in higher mBMI groups, independent of maternal @entity6 diagnosis. CONCLUSION: This study demonstrated a significant association between higher mBMI groups and NICU admissions independent of diagnosis of maternal comorbidities. However, accounting for @entity4053 eliminating this association suggests a pre-clinical @entity6 pathology in @entity28 @entity1 that affects newborn outcome. Despite increased percentage of nonwhite mothers in higher mBMI groups, African-American race does not seem to be a significant contributing factor in the increased rate of NICU admission in our population.
