Proton beam irradiation using a light-field technique for the treatment of XXXX .

@entity1 @entity2695 @entity5 @entity3932 @entity3193
BACKGROUND/AIMS: To describe the clinical outcomes of @entity1 with circumscribed and diffuse @entity3193 treated by proton beam irradiation using a nonsurgical light-field technique. METHODS: A retrospective chart review was performed on a series of 19 @entity1 (19 eyes) with @entity3193 treated with proton beam therapy between July 1988 and August 2005. @entity3193 were treated with proton beam irradiation using a light-field technique and doses ranging from 15 to 30 cobalt Gray equivalents (CGE; CGE = proton Gy x relative biological effectiveness 1.1) in 4 fractions. @entity1 with at least 6 months' follow-up were included in the study. Tumor regression, visual acuity, absorption of subretinal fluid, and treatment-associated complications were evaluated by clinical examination and ultrasonography. RESULTS: Visual acuity improved or remained stable in 14 of 18 eyes (78%). Subretinal fluid was initially present in 16 of 19 eyes (84%), and completely resolved in all 16 eyes. Tumor height, as measured by B-scan ultrasonography, decreased in 18 of 19 eyes and remained stable in 1 of 19, as of the last examination. Complications of radiation developed in 9 of 19 eyes (47%) with the total applied dose ranging from 15 to 30 CGE for these 9 eyes. CONCLUSIONS: Proton beam irradiation using a light-field technique without surgical @entity5 localization is an effective treatment option in managing both circumscribed @entity3193 and @entity2695 associated with @entity3932 . A total proton dose as low as 15 CGE applied in 4 fractions appears to be sufficient to reduce @entity5 size, promote absorption of subretinal fluid, and improve or stabilize vision in most @entity1 .
