Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and XXXX .

@entity1 @entity1832 @entity195
OBJECTIVES: @entity1832 ( @entity1832 ) is characterized by relative preservation of the medial temporal lobe compared with @entity195 ( @entity195 ). The differential involvement of the hippocampal subfields in both diseases has not been clearly established, however. We aim to investigate hippocampal subfield differences in  vivo in a clinical cohort of @entity1832 and @entity195 subjects. METHODS: 104 @entity1 (35 DLBs, 36 ADs, and 35 healthy comparison [HC] subjects) underwent clinical assessment and 3T T1-weighted imaging. A Bayesian model implemented in Freesurfer was used to automatically segment the hippocampus and its subfields. We also examined associations between hippocampal subfields and tests of memory function. RESULTS: Both the @entity195 and @entity1832 groups demonstrated significant atrophy of the total hippocampus relative to HC but the @entity1832 group was characterized by preservation of the cornu ammonis 1 (CA1), fimbria, and fissure. In contrast, all the hippocampal subfields except the fissure were significantly atrophied in @entity195 compared with both @entity1832 and HC groups. Among @entity1832 subjects, CA1 was correlated with the Recent Memory score of the CAMCOG and Delayed Recall subscores of the HVLT. CONCLUSIONS: @entity1832 is characterized by milder hippocampal atrophy that was accompanied by preservation of the CA1. The CA1 was also associated with memory function in @entity1832 . Our findings highlight the promising role of hippocampal subfield volumetry, particularly that of the CA1, as a biomarker for the distinction between @entity195 and @entity1832 .
