X chromosome mosaicism in XXXX with recurrent @entity11157 .

@entity1 @entity2208 @entity249 @entity11157 @entity2689 @entity2588
X chromosome mosaicism is usually associated with abnormal sexual development and reproductive performance, such as recurrent @entity2208 , primary or secondary @entity2588 , @entity249 , and @entity11157 . However, there is a paucity of literature which discusses these relationships. From July 1988 to December 1992, a total of 105 couples with a history of recurrent @entity2208 from a genetic counseling clinic and 61 @entity1 with a history of @entity11157 followed up in reproductive endocrinology clinics were assembled, and chromosomal analysis of peripheral blood lymphocytes was carried out. X chromosome mosaicism was found in six individuals (2.9%) out of the 105 couples with recurrent @entity2208 , and in five (8.2%) out of 61 @entity1 with @entity11157 . The karyotypes were 45,X/46,XX/47,XXX in five cases, 45,X/46,X in four cases, and 46,XX/47,XXX in two cases. The cases of complex X chromosome mosaicism (45,X/46,XX/47,XXX) presented recurrent @entity2208 in four cases and @entity11157 in one case. The cases of mosaic @entity2689 (45,X/46,XX) presented @entity11157 in three cases and recurrent @entity2208 in one case. The two cases of mosaic triple-X syndrome (46,XX/47,XXX) presented with @entity11157 and recurrent @entity2208 , respectively. However, the ratio of mosaic cell lines does not correlate well with the phenotypic manifestations in our cases. Our preliminary data suggest that chromosomal analysis should be done routinely in every couple with recurrent @entity2208 and in @entity1 with @entity11157 . The reproductive performance of X chromosome mosaicism is highly variable and difficult to define.(ABSTRACT TRUNCATED AT 250 WORDS)
