Defining the phenotype of XXXX / @entity4531 (RLS/WED): a clinical and polysomnographic study.

@entity1 @entity935 @entity10522 @entity4531 @entity25
UNASSIGNED: Clinical features variability between familial and sporadic @entity4531 / @entity4531 (RLS/WED) has been previously reported. With this retrospective cohort study, we aimed to determine the clinical and polysomnographic characteristics of 400 RLS/WED @entity1 . @entity1 with familial RLS/WED were significantly younger than sporadic RLS/WED, while clinical and polysomnographic characteristics were similar in both groups. No difference was found for the age-at-onset between idiopathic and secondary RLS/WED. @entity10522 ( @entity10522 ) index and REM sleep time were higher in idiopathic RLS/WED. Time of onset of symptoms was in the evening or at bedtime in 28.04 and 37.80  % of @entity1 , respectively, while in 21.34  % of @entity1 onset was more than 1  h after sleep onset. Impulse control and compulsive behaviours (ICBs) were found in 13.29  % @entity1 on @entity935 agonist therapy. Our analyses support the hypothesis that @entity1 with a familial history of RLS/WED may have a genetic component. Nevertheless, the dichotomy between early and late onset disease seems to be less sharp than previously reported. A large proportion of RLS/WED @entity1 can have atypical features, therefore making the diagnosis challenging. Some cases can be missed even when the @entity1 refers to a sleep specialist, as revealed by the partial absence of daytime symptoms, the high comorbidity with @entity25 and the high percentage of symptoms beginning after sleep onset. This draws attention on the importance of a careful evaluation of the @entity1 , to recognize potentially treatable secondary forms of RLS/WED.
