Pharmacological blockade of the globus palidus-induced inhibitory response of subthalamic cells in the XXXX .

@entity1026 @entity6341 @entity1246 @entity2228 @entity1027 @entity3652 @entity5094 @entity35
The aim of the present study was to investigate, with extracellular recording and microiontophoretic techniques, the possibility that @entity1246 ( @entity1246 ) is the transmitter substance in the pallido-subthalamic (GP-STN) pathway. Experiments were carried out in 94 @entity35 , anesthetized with @entity3652 . Among the 236 recorded STN neurons, 85 were inhibited by GP stimulation. This inhibition lasted 10--20 msec (mean duration +/- S.E.M. 13.45 +/- 0.5 msec). Control stimulations located either in the internal GP or in the striatum never elicited the same type of response as they did in the STN. STN neurons were inhibited by microiontophoretically applied @entity1246 or @entity6341 . Iontophoretically applied @entity1027 or @entity5094 reversibly blocked the GP-evoked inhibition at doses which blocked the @entity1246 inhibitory responses but not those produced by @entity2228 . The results are consistent with the hypothesis that @entity1246 is the transmitter releasted by the inhibitory pallido-subthalamic pathway, and are in agreement with recent biochemical data. Nevertheless, on a few cells, @entity1026 blocked the GP-induced inhibition. This results is discussed in relation to the specificty of @entity1246 and @entity2228 antagonists.
