Confocal microscopy for the histological fluorescence pattern of a recurrent XXXX : case report.

@entity1 @entity5 @entity11 @entity2518 @entity1653
BACKGROUND AND IMPORTANCE: Fluorescence-guided resection with @entity2518 ( @entity2518 ), which has shown promising results in the resection of @entity11 , has been used for @entity1653 resection in an attempt to more clearly delineate the @entity5 margin. However, no article has investigated the fluorescence pattern of @entity1653 on a histological level. Understanding the microscopic pattern of fluorescence could help assess the precision and utility of using @entity2518 for these @entity5 . We present the case of a recurrent @entity1653 operated on with @entity2518 fluorescence-guided resection for delineation of @entity5 tissue from surrounding uninvolved dura. CLINICAL PRESENTATION: A 53-year-old @entity1 presented with recurrent @entity1653 of the falx. Prior treatment included surgical resection 6 years earlier with subsequent fractionated radiation therapy and radiosurgery for @entity5 progression. The @entity1 was given @entity2518 20 mg/kg body weight dissolved in 100 mL water 3 hours before induction of anesthesia. Intraoperative fluorescence was coregistered with preoperative imaging. Neuropathological analysis of the resected falx with confocal microscopy enabled correlation of fluorescence with the extent of @entity5 on a histological level. CONCLUSION: Fluorescence guidance allowed clear intraoperative delineation of @entity5 tissue from adjacent, uninvolved dura. On a microscopic level, there was a very close correlation of fluorescence with @entity5 , but some @entity5 cells did not fluoresce.
