Lymphocyte subpopulations in pregnancy complicated by XXXX .

@entity1 @entity404 @entity101 @entity1075 @entity2940 @entity3138 @entity1468 @entity4071 @entity2902 @entity2071 @entity393 @entity405
The immune responsiveness of @entity1 is altered during pregnancy in order to retain protective properties against disease and at the same time allow tolerance of the fetus. Diseases such as @entity1468 ( @entity1468 ) have been suggested to arise as a result of maladaptations in these immune alterations. Here we evaluate the effect of @entity1468 on the composition of peripheral blood lymphocyte subpopulations using lymphocyte surface antigen expression. Fifty-four @entity1 of various parities with pregnancy-induced @entity101 (PIH) (39 non-proteinuric and 14 proteinuric) and matched controls (30 normotensive pregnant @entity1 (NTP) and 15 healthy non-pregnant @entity1 (NP)) were investigated. Monoclonal antibodies specific for @entity1 T lymphocytes and subpopulations: @entity3138 , CD3, @entity404 , @entity405 , @entity1075 and activation markers: @entity2902 , CD45RA, CD45RO, @entity2071 AND HLA(-)DR were used and detected using a two-colour fluorescence analysis with an automated flow cytometer. The total number of T lymphocytes: @entity3138 , CD3, @entity404 , @entity405 and @entity1075 were significantly decreased in PIH particularly @entity1468 (P<0.05). T cells expressing NK surface markers (CD3/ @entity4071 (+) @entity2940 ) and @entity404 cells expressing HLA(-)DR were higher in @entity1468 . @entity405 (+)HLA(-)DR(+) cells and T-helper cells expressing adhesion molecules) @entity404 (+) @entity2071 (+)) were higher in NTP than in NP and @entity1468 (P<0.05, 0.05). @entity1468 is associated with elevated levels of @entity404 (+)HLA(-)DR(+), and CD3(+)NK cells but decreased total numbers of T lymphocytes, and the CD3(+) @entity2902 (+) subpopulation. These findings indicate systemic alterations in maternal immunity associated with the @entity1468 state. This feature of the disease may contribute to abnormal adaptation to pregnancy resulting in @entity1468 and PIH, promoting adverse outcomes including @entity393 .
