XXXX / @entity18842 and @entity16106 upregulation might be associated with hormone receptor status and prognosis in @entity1204 .

@entity1204 @entity172 @entity1420 @entity23106 @entity189 @entity18842 @entity16106 @entity3 @entity4348
The aim of this study was to compare the clinicopathological significance of @entity23106 / @entity18842 and @entity16106 expression in @entity4348 ( @entity4348 ) versus nonendometrioid @entity189 (NECs) and to assess their correlation with hormone receptor status. @entity23106 / @entity18842 and @entity16106 expression in 154 @entity1204 was determined by qRT-PCR. The status of @entity172 and @entity1420 receptor (ER/PR) was assessed using immunohistochemistry. @entity23106 / @entity18842 and @entity16106 increased significantly in @entity4348 and in NECs. The expression level of @entity23106 was significantly higher in NECs than in @entity4348 (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher @entity23106 expression, while an inverse trend existed in @entity4348 . @entity16106 upregulation occurred frequently in NECs without lymph node @entity3 (P = 0.030), whereas such association was not present in @entity4348 . Interestingly, In @entity4348 , @entity23106 / @entity18842 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of @entity16106 was higher in the hormone receptor positive subgroups and the association between @entity16106 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between @entity23106 / @entity18842 and ER or PR status. Meanwhile, in @entity4348 , @entity23106 upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that @entity23106 / @entity18842 and @entity16106 increased significantly in @entity4348 and in NECs. However, they might behave differently in @entity4348 versus NECs. @entity23106 / @entity18842 and @entity16106 might be associated with hormone receptor status in @entity1204 and may possess prognostic impacts.
