XXXX after transcatheter aortic valve implantation: results from a large multicenter registry.

@entity1 @entity712 @entity326 @entity794 @entity47 @entity884
BACKGROUND: We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of @entity884 ( @entity884 ) after transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: This multicenter registry included 53 @entity1 (mean age, 79  8 years; @entity1 , 57%) who suffered @entity884 after TAVI of 7944 @entity1 after a mean follow-up of 1.1  1.2 years (incidence, 0.67%, 0.50% within the first year after TAVI). Mean time from TAVI was 6 months (interquartile range, 1-14 months). Orotracheal intubation (hazard ratio, 3.87; 95% confidence interval, 1.55-9.64; P=0.004) and the self-expandable CoreValve system (hazard ratio, 3.12; 95% confidence interval, 1.37-7.14; P=0.007) were associated with @entity884 (multivariate analysis including 3067 @entity1 with individual data). The most frequent causal microorganisms were coagulase-negative staphylococci (24%), followed by @entity794 (21%) and enterococci (21%). @entity47 were present in 77% of @entity1 (transcatheter valve leaflets, 39%; stent frame, 17%; mitral valve, 21%). At least 1 complication of @entity884 occurred in 87% of @entity1 ( @entity712 in 68%). However, only 11% of @entity1 underwent valve intervention (valve explantation and valve-in-valve procedure in 4 and 2 @entity1 , respectively). The mortality rate in hospital was 47.2% and increased to 66% at the 1-year follow-up. @entity884 complications such as @entity712 (P=0.037) and @entity326 (P=0.002) were associated with increased in-hospital mortality. CONCLUSIONS: The incidence of @entity884 at 1 year after TAVI was 0.50%, and the risk increased with the use of orotracheal intubation and a self-expandable valve system. Staphylococci and enterococci were the most common agents. Although most @entity1 presented at least 1 complication of @entity884 , valve intervention was performed in a minority of @entity1 , and nearly half of the @entity1 died during the hospitalization period.
