Detection, staging and clinical implications of XXXX .

@entity1 @entity146 @entity5 @entity1358 @entity703
OBJECTIVE: To compare the epidemiologic, clinical, and pathologic characteristics of symptomatic and @entity1358 ( @entity1358 ) in Jordan, with some emphasis on age distribution and its potential effect in defining groups of @entity1 that may benefit from early detection programs. We compared our results with the published western figures. METHODS: Records of 119 @entity1 with @entity703 diagnosed during the period January 1992 to December 2001 at Jordan University of Science and Technology, Irbid, Jordan were reviewed. Age, gender, discovery circumstances of the @entity5 , radiologic and biologic workup, treatment, @entity5 node metastasis classification, and histologic features of the @entity5 were analyzed. RESULTS: The mean @entity1 age was 54, and the male to female ratio was 3.4:1. The annual frequency rate for @entity1358 per 100,000 population was 1.2 for both sexes, while for @entity1 was 1.8 and for @entity1 was 0.5. Twenty-six percent of @entity5 were discovered accidentally. The mean age at the time of diagnosis was not influenced by the discovery circumstances. The incidental detection group had significantly small size of @entity5 (5.6 cm circumference (c.f) 8.1 cm), lower stage and lower histological grading. In the symptomatic group; @entity1 have significantly lower mean size of @entity5 than @entity1 (5.5 cm c.f. 7.7 cm; p = 0.005; t-test), while there is no significant difference among the incidental group. A radical nephrectomy was performed in 92% of the cases, and in 8% of the cases, conservative management was adopted. CONCLUSION: The present study showed that the incidence rates of @entity1358 in Jordan and other Middle East countries were less than most of the western countries. @entity703 in Jordan tend to affect @entity1 at a remarkably young age. This is mostly a reflection of the high proportion of young @entity1 in this country. This high portion of young @entity1 may explain the low incidence as @entity703 is known to increase with age. Significant numbers of @entity1358 were detected incidentally with lower pathological stage and grade. Subsequently these clinically and histologically less @entity146 lead to better survival and decreased recurrence. These data efforts should be directed to the development of a screening protocol to detect these lesions early, so that they may be prevented from progressing to the point when symptoms are apparent and prognosis becomes worse.
