Reduced non-relapse mortality after reduced intensity conditioning in advanced XXXX .

@entity1 @entity137 @entity1072 @entity3118 @entity205 @entity2132 @entity618 @entity1863 @entity1499
We studied in 30 @entity1 with progressive or relapsing @entity1072 ( @entity1072 ) if hematopoietic stem cell transplantation (HSCT) after conditioning with @entity3118 , @entity1863 and ATG is effective and if treatment related mortality can be reduced compared to myeloablative conditioning regimens. @entity1 had 15 matched related and 15 matched unrelated donors. @entity2132 ( @entity2132 ) prophylaxis consisted of @entity205 alone or a combination with "short course" @entity1499 or @entity618 . The median follow-up is 24 months. At last follow up 11 @entity1 were in complete and 13 in partial remission. Six @entity1 had stable or progressive disease. Late complete remissions occurred up to one year after transplantation and the number of @entity1 with CR is still increasing. Four @entity1 died due to treatment related complications resulting in a probability of treatment-related mortality of 15% (CI 95%, 1% to 29%) at 2 years. The probability of overall survival and progression free survival at two years was 79% and 61%, respectively. In conclusion, HSCT after reduced conditioning may lower the treatment-related @entity137 and has the capacity to induce complete remissions.
