The involvement of growth hormone-binding protein in altered GH-IGF axis in XXXX .

@entity1 @entity2301 @entity442 @entity10116 @entity1723 @entity413 @entity9045
High GH and low @entity442 are well known in @entity1723 @entity1 . To delineate this altered GH- @entity442 axis in @entity1723 , we investigate the role of @entity9045 ( @entity9045 ) in relation to the metabolic and nutritional states. MATERIALS AND METHODS: Forty seven @entity1 with @entity1723 , mean 13.7 years, were evaluated. Blood samples were obtained before insulin injection and breakfast to test for plasma @entity413 (PG), @entity442 , @entity10116 , @entity2301 , total and complex @entity9045 (tGHBP and cGHBP), and HbA1c. Urine samples were collected in the morning for urinary GH (uGH). The difference between tGHBP and cGHBP is defined as fGHBP. The levels of PG and HbA1C were not correlated with each level of tGHBP, cGHBP, fGHBP or uGH. The levels of tGHBP, cGHBP and fGHBP were not all correlated with uGH. Both the levels of @entity442 and body mass index (BMI) were positively correlated with fGHBP. The duration of @entity1723 was negatively correlated with tGHBP, cGHBP and fGHBP. DISCUSSION: As the previous report of the relationship between GH binding reserve to @entity9045 and @entity442 or BMI in non-diabetic subjects, fGHBP again showed statistical links with these parameters in @entity1723 . We therefore suggest that @entity9045 , especially its free form, may reflect a malmetabolic state of @entity1723 liver, resulting in an altered GH- @entity442 axis.
