Serum soluble XXXX is a valuable prognostic marker in @entity356 .

@entity1 @entity5 @entity2802 @entity3 @entity14 @entity356 @entity19597
BACKGROUND: @entity19597 ( @entity19597 ) regulates leukocyte tissue infiltration. Elevated serum soluble @entity19597 (sVAP-1) levels occur in certain diseases having an inflammatory component. We previously showed in @entity14 that sVAP-1 expression is significantly higher relative to controls, and this decreased expression is associated with poor prognosis and lymph node and liver @entity3 . However, sVAP-1 expression has not been described for @entity356 . This study determines the relationship between preoperative serum sVAP-1 levels and clinicopathological features and prognosis in @entity356 . METHODS: Preoperative serum was collected from 107 @entity356 @entity1 and 33 normal controls. sVAP-1 levels were assayed by enzyme-linked immunosorbent assay. RESULTS: The mean sVAP-1 level for @entity5 @entity1 was significantly higher relative to controls, and decreased with disease progression. @entity5 size, serosal invasion, lymph node @entity3 , peritoneal dissemination, and @entity2802 classification was significantly correlated with sVAP-1 level. sVAP-1 is also an independent predictive marker for lymph node @entity3 . @entity1 having low sVAP-1 levels had significantly poorer prognosis relative to @entity1 having elevated sVAP-1 in all or stages I-III @entity356 @entity1 , respectively. CONCLUSIONS: Low sVAP-1 levels are associated with poor prognosis in @entity356 . Determining sVAP-1 levels may be valuable for predicting prognosis and lymph node @entity3 .
