Fibrinolytic system in adolescents: response to XXXX stress tests.

@entity1 @entity1031 @entity432 @entity2289
Recent studies indicate that the incidence of @entity1031 is increasing as a secondary complication in @entity1 with serious underlying diseases. The mechanism to eliminate these thrombi via the thrombolytic system in @entity1 is unknown. The baseline fibrinolytic system is age dependent, with significant variation between @entity1 and adults. Adult studies would suggest that the fibrinolytic response to @entity432 has more clinical relevance than the baseline fibrinolytic system. The aim of this study was to determine whether the fibrinolytic response to @entity432 stress testing in healthy adolescents differs from the response in healthy adults. Healthy adolescents (13-18 y) from a school population and normal adults were recruited. Pre- and postvenous occlusion blood samples were collected using standard techniques. Plasma tissue plasminogen activator, @entity2289 , plasminogen, alpha(2)-antiplasmin, alpha(2)-macroglubulin, D-dimers, euglobulin lysis time, and fibrinogen were measured on each sample. Adolescents had significantly decreased tissue plasminogen activator antigen levels and increased @entity2289 activity levels after @entity432 , resulting in significantly prolonged euglobulin lysis times. The results of our study confirm developmental differences in the fibrinolytic response to @entity432 stress testing. The age-related differences in fibrinolytic response to @entity432 of younger @entity1 and the significance of these differences on the pathophysiology of @entity1031 in @entity1 require further studies.
