The XXXX : pathology, staging, treatment.

@entity1 @entity981 @entity706 @entity146 @entity5 @entity784 @entity1893
The @entity1893 include a broad range of @entity5 derived from the T cells and B cells and their precursors in the lymphoid system. Although they are not among the most common @entity5 , the @entity706 have engendered a great deal of interest among researchers because of their interesting biology and responsiveness to therapy. The @entity1893 include at least ten major subtypes of diseases with different morphologic characteristics and clinical behavior. Based upon survival characteristics, it is convenient to divide the @entity706 into three broad categories, low grade, intermediate grade, and high grade. The low @entity706 usually arise in middle age or older individuals (median age, 55 years). They are derived from B cells and often have a follicular architectural pattern. They usually present with advanced stages of disease, often by virtue of bone marrow involvement. Nevertheless, @entity1 are usually asymptomatic and may even have spontaneous regressions of disease. These @entity706 are responsive to a broad range of therapies including irradiation, single agent or multi-agent chemotherapy, or combined modality therapy. They are also affected by treatment with biologicals such as alpha interferon and monoclonal antibodies. Unfortunately, response to any of these therapies is often transient and relapse is common. The intermediate @entity706 include the common large cell @entity706 (follicular or diffuse) and @entity1893 . The @entity706 , together with the high grade @entity706 , are often grouped together for the development of management strategies. These @entity706 may be derived from B cells or T cells. They occur over a broader age range than the low @entity706 and they are much more @entity146 in their natural behavior. Effective treatment programs have been developed for both limited and advanced clinical stages of disease. In limited disease, moderately intensive chemotherapy is often combined with involved field irradiation. In @entity5 , more @entity146 combination chemotherapy programs are usually employed. From 40% to 80% of @entity1 may be cured with these approaches, depending upon the initial extent of disease. Two types of high grade @entity981 and small noncleaved cell are particularly @entity146 in their behavior. @entity981 is a @entity784 that often arises in adolescent males and presents with a large mediastinal mass, marrow, and CNS involvement. It closely resembles @entity981 ( @entity981 ) and similarly intensive chemotherapy programs as are utilized in @entity981 may be successful in its management.(ABSTRACT TRUNCATED AT 400 WORDS)
