Decreasing incidence and severity of @entity306 in prematurely born XXXX .

@entity1 @entity5719 @entity548 @entity306
OBJECTIVE: To examine incidence and severity of @entity306 ( @entity306 ), and associated factors among preterm survivors (gestational age <34 weeks), admitted to a neonatal intensive care unit from 1990-2005. STUDY DESIGN: Eighteen antenatal, perinatal and postnatal factors were analyzed. The cohort was divided in four birth periods: 1990-1993 (n=661), 1994-1997 (n=726), 1998-2001 (n=723), and 2002-2005 (n=850). The Gross Motor Function Classification System was used as primary outcome measure (mean age: 32.9    5.3 months). Logistic regression analyses were used. RESULTS: @entity306 incidence decreased from 6.5% in period I, to 2.6%, 2.9% and 2.2% (P<.001) in period II-IV, respectively. Simultaneously, @entity5719 ( @entity5719 ) decreased from 3.3% in period I to 1.3% in period IV (P=.004). Within the total cohort (n=3287), @entity5719 grade III decreased from 2.3% in period I to 0.2% in period IV (P=.003). The number of @entity1 with Gross Motor Function Classification System levels III-V decreased from period I to IV (P=.035). Independent risk factors for @entity306 were @entity5719 and severe @entity548 , whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. CONCLUSION: @entity306 incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe @entity5719 .
