The role of the @entity7066 -63g>a and @entity2215 -1327c>t telomerase polymorphisms in the study of @entity1 with XXXX .

@entity1 @entity1187 @entity7066 @entity66 @entity101 @entity41070 @entity71795 @entity453 @entity2215 @entity65
AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity66 , like @entity65 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7066 --63G>A ( @entity71795 ) and @entity2215 --1327C>T ( @entity41070 ), on the whole spectrum of acute @entity453 . METHODS: We studied 150 middle aged @entity1 admitted for an @entity1187 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity2215 polymorphism was more prevalent among @entity101 @entity1 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity453 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity101 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity453 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity1187 .
