@entity24549 and @entity24551 Gene Polymorphisms in Type 2 XXXX in the Turkish Population.

@entity1 @entity71153 @entity71154 @entity24549 @entity6 @entity412 @entity164 @entity24551 @entity4334 @entity165
OBJECTIVE: The aim of the present study was to investigate the relationship between @entity24549 and @entity24551 gene polymorphisms and plasma lipid concentrations in Turkish @entity1 with @entity6 . METHODS: Included in this study were 80 @entity1 with @entity164 2 @entity6 and 73 healthy controls. Two selected single @entity4334 polymorphisms in ABC transporter genes, @entity24549 ( @entity71153 ) and @entity24551 ( @entity71154 ), were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The rate of having the @entity24551 AA genotype (p=0.001) was significantly higher in the @entity1 than in the control subjects. Correspondingly, the rates of having the AG genotype (p=0.001) and the G allele (p=0.001) were significantly lower in the @entity1 than in controls. Upon comparing the groups regarding @entity24549 , the frequencies of occurrence of the GG genotype (p=0.031) and G allele (p=0.003) were considerably higher in @entity1 than in control subjects. In the @entity1 , the rates of having the CC genotype (p=0.003) and the C allele (p=0.031) were also significantly lower than those in control subjects. There was no significant difference between G5 and G8 polymorphism and lipid levels in the study groups. The @entity24551 AA genotype carriers had higher @entity412 (p=0.045) and very low-density- @entity165 (p=0.045) levels than the @entity24551 GG genotype carriers in all study populations. CONCLUSIONS: These results indicate that the AA genotype for @entity24551 and the GG genotype and G allele for @entity24549 are risk factors for @entity6 . This study reveals the first data concerning the @entity24549 and @entity24551 gene polymorphisms in Turkish @entity1 with @entity6 .
