A comparison of @entity3175 and XXXX as endoscopy premedication assessing changes in ventilation and @entity26 saturation.

@entity1 @entity26 @entity3175 @entity1363
1. One hundred and two consecutive @entity1 undergoing upper gastrointestinal endoscopy were randomised to be sedated with either intravenous @entity3175 (Diazemuls-Kabi Vitrum) or intravenous @entity1363 (Hypnovel-Roche). It was assumed that @entity1363 was likely to be approximately twice as potent as @entity3175 on the basis of previous work. 2. All @entity1 had an ear oximeter attached throughout the procedure to record continuously their level of @entity26 saturation. 3. All 102 @entity1 had pre-endoscopy respiratory function tests measured and 100 wore an induction plethysmograph vest to allow continuous estimation of respiratory rate and excursion. The plethysmograph was calibrated using a pneumotachygraph, so baseline, post-injection and post-endoscopy minute volumes could be estimated. 4. The age, sex ratio and pre-endoscopy respiratory function tests of the 51 @entity1 given intravenous @entity3175 in a mean dose (s.d.) of 11.5 (5.8) mg over a mean of 3.4 (0.9) min) were similar to that of the 51 @entity1 sedated with intravenous @entity1363 (mean dose 6.0 (2.8) mg over 3.3 (0.9) min. 5. Both drugs significantly reduced minute volume (P less than 0.001) and @entity26 saturation (P less than 0.001). @entity1363 appeared to produce slightly greater hypoxaemia with 57% having falls in @entity26 saturation of greater than 2.5% compared with only 35% given an equivalent dose of @entity3175 . 6. Ventilation was still less than baseline when re-checked some minutes after removal of the gastroscope. The speed of recovery appeared faster after @entity3175 sedation which is in contrast to its longer pharmacological half-life.(ABSTRACT TRUNCATED AT 250 WORDS)
