[Outcome of surgical treatment of malignant XXXX of the brain].

@entity1 @entity75 @entity5 @entity816 @entity204 @entity463
BACKGROUND: The aim of this study was to analyze the outcome after the surgical treatment of @entity1 with malignant @entity75 , as well as the factors influencing the outcome. Retrospective study was performed on 145 operated @entity1 (102 with @entity463 multiforme, and 43 with @entity816 ). METHODS: Clinical state was graded according to the Yasargil scale (grades I-IV) and the Karnofski score, and the outcome was defined either as good (better or unchanged clinical state) or as poor (deteriorated state or @entity204 ). The outcome was correlated with @entity1 age and preoperative clinical condition, as well as with the localization, extensiveness and the extent of resection of the @entity5 . RESULTS: Preoperative clinical state of @entity1 most frequently corresponded to grades II-III (75.9%). Radical resection was done in 48.3%, subtotal in 15.2%, partial in 30.3%, and biopsy was performed in 6.2% of @entity1 , with the total operative mortality of 16.5%, morbidity of 9.7%, and good postoperative outcome in 73.8% of the @entity1 . The incidence of good postoperative outcome did not significantly depend on the @entity5 location (42.6-78.3%), cortical presentation, the extent of resection (68.2-75.7%), and preoperative clinical state (67.8-81.5%). Good outcome was seen in 82.7% of @entity1 with one, and in 53.8% of @entity1 with three or more infiltrated lobes (p < 0.01). @entity1 with poor outcome were significantly older in average than the @entity1 with good outcome (58.9 +/- 12.1 and 50.9 +/- 13.4 years of age, respectively; p < 0.05). Operative mortality was 7.4%, and 27.3% for clinical grades II and IV (p < 0.05), namely 11% and 23.8% for the @entity1 with the Karnofski score above and under 50 (p < 0.05), respectively. CONCLUSION: The outcome after the operative treatment of malignant @entity816 significantly depended on @entity1 age and the extensity of the @entity5 . For such @entity1 operative mortality was also significantly influenced by clinical preoperative state.
