@entity410 -induced gene expression in area XXXX of the mouse hippocampus.

@entity4778 @entity410 @entity39769
Synaptic plasticity in the hippocampus requires activity-dependent gene expression. We have therefore profiled gene expression in area @entity4778 following the induction of an electroshock-evoked maximal @entity410 . Using cDNA microarrays, the differential expression of approximately 9000 cDNAs was examined. In situ hybridization on 14 transcripts that showed strongest modulation in the microarray screen (1.8-2-fold) confirmed the differential expression of a single gene that encodes for the nuclear hormone receptor @entity39769 ( @entity39769 , @entity39769 ). Although this gene is only modestly up-regulated (approximately 2-fold) in area @entity4778 , in situ hybridization revealed that maximal @entity410 induce a marked (approximately 12-fold) up-regulation of @entity39769 in the dentate gyrus. These data support the notion [French et al. (2001) Eur. J. Neurosci., 13, 968-976] that @entity4778 pyramidal neurons are more refractory than granule cells of the dentate gyrus with respect to activity-dependent gene transcription. Furthermore, our results argue against a large cohort of activity-dependent genes in area @entity4778 .
