Gray matter structural compromise is equally distributed in left and right XXXX .

@entity1 @entity410 @entity1315 @entity194
UNASSIGNED: In drug-resistant @entity1315 ( @entity1315 ), MRI studies have shown consistent mesiotemporal and neocortical structural alterations when comparing @entity1 to healthy controls. It remains, however, relatively unclear whether the side of @entity410 focus differentially impacts the degree of structural damage. This work performed a comprehensive surface-based analysis of mesiotemporal and neocortical morphology on preoperative 1.5 T MRI in 25/35 LTLE/RTLE @entity1 that achieved @entity410 freedom after surgery (i.e., Engel-I outcome; 7        2 years follow-up), an imaging-independent confirmation of focus lateralization. Compared to 46 age- and sex-matched controls, both @entity1315 groups displayed marked @entity194 in mesiotemporal regions, while cortical thinning was bilateral. Direct contrasts between LTLE and RTLE did not reveal significant differences. Bootstrap simulations indicated low reproducibility of observing a between-cohort difference; power analysis revealed that more than 110 @entity1 would be necessary to detect subtle differences. No difference between LTLE and RTLE was confirmed when using voxel-based morphometry, an independent proxy of gray matter volume. Similar results were obtained analyzing a separate 3 T dataset (15/15 LTLE/RTLE @entity1 ; Engel-I after 4        2 years follow-up; 42 controls). Our results strongly support equivalent gray matter compromise in left and right @entity1315 . The morphological profile of @entity410 -free @entity1 , presenting with ipsilateral mesiotemporal and bilateral cortical @entity194 , motivates the development of neuromarkers of outcome that consider both mesiotemporal and neocortical structures. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.
