A Region-of-Interest Approach for Detecting Progression of XXXX With Optical Coherence Tomography.

@entity1 @entity16 @entity726 @entity548
IMPORTANCE: Detecting progression of @entity16 is often challenging. OBJECTIVE: To test the feasibility of using frequency-domain optical coherence tomography (FD-OCT) and a region-of-interest (ROI) approach to measure progressive changes in @entity16 . DESIGN, SETTING, AND @entity1 : Among a group of @entity1 in an institutional @entity726 practice who were likely to show @entity726 progression, eyes with a history of an @entity548 ( @entity548 ) confirmed by stereophotography were followed up with FD-OCT cube scans of the optic disc. All @entity1 underwent FD-OCT scans on at least 2 occasions separated by at least 1 year (mean, 3.45 years; range, 1.42-6.39 years). Because we were not studying the effects of an optic @entity548 , no constraint was placed on the time between the documentation of an optic @entity548 and the first scan used in the analysis. MAIN OUTCOMES AND MEASURES: After en face images of the FD-OCT scan were aligned based on the blood vessels, circumpapillary images were derived for an annulus 100   m in width, and the retinal nerve fiber layer (RNFL) thickness profiles were plotted for the first and last visits. The ROI width associated with the optic @entity548 was defined as the region of the RNFL profile below the 1% CI based on healthy norms. The change in the ROI width was compared with the change in the global RNFL thickness, which was obtained by averaging the circumpapillary RNFL thickness. RESULTS: The change in the ROI width (mean [SD], 8.0   [6.4  ]; 95% CI, 4.9   to 11.1  ; range, -0.7   to 19.3  ) was significant (P   <   .001, 2-tailed t test) while the change in the global thickness (mean [SD], 2.40 [5.87]  m; 95% CI, -0.48 to 5.28  m) was not significant (P   >   .12, 2-tailed t test). Although 15 of the 16 ROIs increased in width between visits, only 11 showed a decrease in the global RNFL thickness. CONCLUSIONS AND RELEVANCE: For detecting progression of local RNFL damage in @entity1 with @entity726 , an OCT ROI approach appears superior to the OCT global RNFL thickness measure typically used.
