Mitigating effect of Indian propolis against XXXX induced bone marrow toxicity.

@entity137 @entity5 @entity19 @entity1138 @entity1139 @entity6620
UNASSIGNED: A major drawback with @entity5 chemotherapy is its severe toxic effects on non-target tissues. Assessment of natural products for their protective effect against anticancer drugs-induced @entity137 is gaining importance in @entity5 biology. The present study was aimed at assessing the protective effect of @entity6620 ( @entity6620 ) against @entity1138 ( @entity1139 )-induced genotoxicity and @entity137 . Swiss albino @entity19 were injected with various doses of @entity6620 (100, 200, 300, 400, 600 and 800  mg/kg b. wt., i.p) 1  h prior to @entity1139 (8  mg/kg, i.p.) injection. The geno- and cyto- @entity137 were evaluated in @entity19 by performing bone marrow micronucleus and TUNEL assays. In vitro antioxidant and lipid peroxidation inhibitory assays were carried out to understand the mechanism of the protective effects. The significant increase in the frequency of micronculeated cells (12.51      0.48), apoptotic cells (23.43      1.86) and reduction in P/N ratio (0.69      0.04) compared with control indicated the potential geno- and cytotoxic effects of @entity1139 in bone marrow. Pretreatment with @entity6620 resulted in the significant recovery of the toxic effects induced by @entity1139 . @entity6620 at 400  mg/kg  b. wt. was found to be the optimum dose imparting the maximum protective effects. The in vitro antioxidant and lipid peroxidation inhibitory assays suggest that the extract possesses substantial free radical scavenging activities. In conclusion, @entity6620 possesses substantial geno- and cyto-protective properties against @entity1139 , which could be mediated through efficient free radical scavenging and inhibitory effect on lipid peroxidation.
