Fluorinated molecules in the diagnosis and treatment of XXXX .

@entity8984 @entity149 @entity9555 @entity2033 @entity191 @entity9576 @entity25279 @entity179 @entity2862 @entity195
The use of fluorinated molecules as drugs and imaging agents for @entity9555 has been studied extensively over the years. Incorporating a @entity2862 atom into the structure of a drug changes its physiochemical properties and can thereby lead to much more desirable pharmacokinetic and pharmacodynamic properties. This change can help to facilitate blood-brain barrier permeability, which is a critical matter for drugs intended for CNS activities. @entity2862 incorporation into structures of drugs for the treatment of @entity179 has been an attractive field for drug discovery. Such incorporation can greatly influence the physicochemical properties, metabolic stability and receptor binding affinity of the resulting molecule. Some studies have shown that when a proton was substituted with @entity2862 , the binding or inhibitory potency was greatly increased. The @entity2862 -18 isotope, @entity8984 , is utilized in detection and diagnosis of @entity179 , whereas @entity25279 compounds are used in the treatment of these diseases and in MRI. @entity8984 is widely used in PET imaging because it offers the advantage of a longer half-life compared with other radionuclides. It is used for imaging various receptors and transporters that have been linked to @entity179 , such as @entity195 , @entity191 , @entity2033 and @entity9576 . @entity2862 plays an important role in the diagnosis and treatment of many @entity149 , including @entity179 . The use of @entity2862 in the diagnosis and treatment of @entity179 , such as @entity195 and @entity191 , will be discussed in this review.
