Association Between Physical Fitness and Cognitive Function in XXXX : Does Disability Status Matter?

@entity1 @entity73 @entity26 @entity717 @entity15
Background. @entity73 is a highly prevalent, poorly managed, and disabling consequence of @entity15 ( @entity15 ). Exercise training that improves physical fitness represents a promising approach for managing @entity73 in @entity1 with @entity15 . There is limited evidence that physical fitness is associated with multiple domains of @entity73 across levels of @entity717 . Objective. This cross-sectional study examined the associations among aerobic capacity, lower limb muscle strength, and cognitive functions in @entity1 with mild, moderate, and severe @entity717 . Methods. The sample included 62 @entity1 with mild (n = 20), moderate (n = 21), and severe (n = 21) @entity717 . The @entity1 underwent neuropsychological assessments of cognitive processing speed (CPS; Symbol Digit Modalities Test [SDMT]), verbal memory (California Verbal Learning Test-2 [CVLT-2]), and visual memory (Brief Visuospatial Memory Test-Revised [BVMT-R]). All @entity1 further underwent testing for measuring aerobic capacity (ie, peak @entity26 consumption) and muscular strength (ie, peak torque of knee flexors and extensors). Results. Aerobic capacity and muscular strength outcomes were associated with SDMT (r = .35-.41), but not CVLT-2 or BVMT-R (r < .19) scores in the overall sample. Aerobic capacity (r = .42) and knee flexor peak torque (r = .39) were associated with SDMT scores in @entity1 with mild disability, but not in those with moderate (r < .06) and severe (r < .14) disability. Conclusions. These results support examining aerobic and resistance exercise training programs for improving CPS, particularly among @entity1 with mild @entity717 .
