Large-core needle biopsy for diagnosis and treatment of XXXX .

@entity1 @entity0 @entity588 @entity189 @entity876 @entity1758 @entity1558 @entity1722
PURPOSE: Large-core needle biopsy (LCNB) has become a more widely used technique in the evaluation of @entity1558 . This study was undertaken to access the accuracy of percutaneous LCNB on @entity1558 and the impact on further proceeding. METHODS: A retrospective review of imaging-guided LCNB of 159 @entity1558 was done. 143 LCNB were taken with ultrasound guided automated spring gun biopsy and 16 stereotactic-guided with vacuum-assisted biopsy device. Histology and morphobiological parameters were compared with subsequent material from surgery. RESULTS: In 113 core biopsies (71%), an infiltrating @entity0 was diagnosed, 5 biopsies (3%) yielded in-situ/atypical lesions and a benign lesion was shown in 38 cases (24%). In 3 cases, insufficient/necrotic material was obtained. 108 @entity1 underwent subsequent surgery. In 100/108 cases (93%), histology on LCNB and surgery was identical. LCNB was false negative in 5 core biopsies (5%). Immunhistochemical stains of hormone receptors, @entity588 , @entity1722 , @entity876 and @entity1758 was comparable on LCNB and on surgical material. Based on the results of LCNB, 17/113 @entity1 (15%) with infiltrating @entity189 were primarily treated with hormones or with neoadjuvant therapy. 32/38 @entity1 (84%) with benign lesions were followed up by imaging control. CONCLUSIONS: In @entity1 with benign lesions on imaging, open biopsies can be avoided by LCNB. In @entity1 with biopsy proven @entity189 , therapy planning is improved. The addition of morphobiological parameters allows early individual treatment.
