Procalcitonin kinetics as a prognostic marker in severe @entity295 / XXXX .

@entity402 @entity1 @entity295 @entity326
BACKGROUND AND AIMS: To evaluate the prognostic value of change (fall) in serum @entity402 ( @entity402 ) in critically ill adults with severe @entity295 / @entity326 . METHODS: This was a prospective observational study in a general purpose Intensive Care Unit of a teaching Institute. @entity402 was measured at admission (D0) and after 72-96 h (D4) by electrochemi-luminescence immunoassay (BRAHMS @entity402 kit) in adults (>18 years) admitted with severe @entity295 or @entity326 . Change in procalcitonin values from D0 to D4 was correlated with the primary outcome, that is, 28 days mortality. All results are reported as median (interquartile range). RESULTS: A total of 171 (100 males) of 181 @entity1 were included. The median age was 46 years (range 19-79). 137 @entity1 were in @entity326 and 34 in severe @entity295 . The sequential organ failure assessment (SOFA) score in all @entity1 was 11 (9-14).91 (53.2%) @entity1 survived at 28 days (survivors). The baseline procalcitonin was similar in two groups (3.48 [1.04-15.85] vs. 5.27 [1.81-23.57] ng/ml in survivors and nonsurvivors [NS] respectively). The procalcitonin change was 1.58 (0.20-8.52) in survivors and 0.28 (-1.38-6.17) in NS (P = 0.01). The C-statistic of percentage change in procalcitonin from D0 to D4 to predict survival was 0.73 (95% confidence interval [CI]: 0.65-0.82) when compared to 0.78 (95% CI: 0.71-0.86) for change of SOFA score. For an absolute fall in procalcitonin of >1 ng/ml, a 70% fall predicted survival with 75% sensitivity and 64% specificity. CONCLUSIONS: In critically ill- @entity1 with severe @entity295 / @entity326 , change (fall) in procalcitonin is associated with good outcome.
