Infectious Ulcerative Keratitis Following XXXX Treatment.

@entity1 @entity1036 @entity6419 @entity2286 @entity2543 @entity3283 @entity86 @entity989
PURPOSE: To report the complication of @entity3283 after laser photocoagulation and pars plana vitrectomy ( @entity2286 ) for @entity989 (ROP). METHODS: A retrospective chart review of @entity1 treated for ROP with plus disease between 2004 and 2013 at University Hospital, Newark, New Jersey. RESULTS: Of the 110 eyes (55 @entity1 ) that underwent treatment for ROP, 8 (7.27%) eyes were noted to develop @entity3283 in 4 neonates (4 eyes after laser photocoagulation and 4 eyes after @entity2286 ). All 8 eyes that developed ulcerative keratitis had a preceding corneal @entity2543 followed by corneal stromal haze. Seven of 8 eyes developed @entity2543 within 8 days of the procedure. All epithelial defects progressed to ulcerative keratitis within 7 days. A total of 10 (9.1%) eyes developed @entity86 , and 8 (80%) of these eyes were ultimately diagnosed as having ulcerative keratitis. Four (4.08%) of 98 eyes treated with laser photocoagulation alone developed infective ulcerative keratitis, compared to 4 (33.33%) of 12 eyes treated with @entity2286 . Because @entity1036 healed, corneal opacification ensued and covered 10% to 90% of the corneal surface area. Five of the 8 eyes had positive culture of corneal scrapings: 2 grew coagulase-negative Staphylococcus and Stenotrophamonas; 1 grew coagulase-negative Staphylococcus; 1 grew @entity6419 viridans, and 1 grew Staphylococcus hominis, @entity6419 , and @entity6419 viridans. All 8 eyes were treated with antibiotic eye drops. CONCLUSIONS: Infectious ulcerative keratitis developed in a small, but significant, percentage of @entity1 undergoing treatment for ROP. Postoperative corneal epithelial defects with subsequent corneal haze appear to be involved in the progression to ulcerative keratitis.
