XXXX receptor status determines oncological benefits of laparoscopic oophorectomy.

@entity1 @entity43 @entity0 @entity2931
A meta-analysis of over 3000 @entity1 in 1992 demonstrated that @entity43 in @entity1 less than 50 years of age produces a highly significant reduction in both disease recurrence and mortality. @entity43 has been offered to premenopausal @entity1 at the University College Hospital in Galway for 12 years. A review of 136 cases with follow-up and examination of disease-free survival and mortality is presented. The influence of @entity2931 receptor status on response and long-term outcome is examined. Premenopausal @entity1 over the age of 40 years were offered bilateral laparoscopic oophorectomy. This procedure was well tolerated with no serious morbidity. A significant difference in disease-free survival and reduction in mortality was observed in the @entity2931 receptor positive group when compared with @entity1 with @entity2931 receptor negative disease. No significant difference in disease-free survival or mortality was observed between the @entity2931 receptor negative group and a comparable control group. These results have influenced our @entity1 selection for this adjuvant treatment. A controlled prospective trial is now necessary to examine the role of laparoscopic oophorectomy in @entity2931 receptor negative, premenopausal @entity1 with @entity0 .
