XXXX : present status.

@entity1 @entity82 @entity455 @entity6 @entity2316 @entity177 @entity292 @entity194 @entity413 @entity454
Between December 1966 and June 1982, 269 transplantations of vascularized pancreas (whole or segmental) were undertaken in 254 @entity6 @entity1 throughout the world. Most of the transplantations were performed in @entity1 with @entity454 who also received kidney grafts; a few @entity1 received pancreatic grafts only. About 25% of the pancreatic grafts are still functioning after periods of various lengths, the longest being five years. To the problem of how to handle the exocrine secretion there are two main approaches: 1) occlusion of the duct with a synthetic polymer and 2) pancreatico-enterostomy. A disadvantage of the former procedure is late @entity82 and @entity194 of the endocrine tissue. With the latter method duct leakage and @entity292 development cannot be completely prevented. In either case, @entity455 cause graft failure in about 20% of the operations. The risk of rejection of the graft seems not to differ significantly from that concerning other allogeneic organs, including the kidney and heart. Most of the @entity1 with a functioning pancreatic graft are normoglycemic: they have a normal or near-normal oral or intravenous @entity413 tolerance and an early insulin response to intravenous @entity413 tolerance and an early insulin response to intravenous @entity413 challenge. Whether the improvement of the motor and sensory nerve conduction velocities observed in some @entity1 whose graft has functioned for a long time is due to the reversal of @entity177 cannot yet be determined. At present, pancreas transplantation at Huddinge Hospital is performed only in conjunction with renal transplantation in @entity1 with end-stage @entity2316 .(ABSTRACT TRUNCATED AT 250 WORDS)
