Computer-aided evaluation of breast MRI for the @entity41 extent and response monitoring in XXXX @entity1 receiving neoadjuvant chemotherapy.

@entity1 @entity5 @entity0 @entity41
OBJECTIVE: To evaluate the accuracy of a computer-aided evaluation program (CAE) of breast MRI for the assessment of @entity41 extent and response monitoring in @entity0 @entity1 receiving neoadjuvant chemotherapy. MATERIALS AND METHODS: Fifty-seven @entity1 with @entity0 who underwent neoadjuvant chemotherapy before surgery and dynamic contrast enhanced MRI before and after chemotherapy were included as part of this study. For the assessment of @entity41 extent after completion of chemotherapy, the mean @entity5 diameters measured by radiologists and CAE were compared to those on histopathology using a paired student t-test. Moreover, the agreement between unidimensional (1D) measurement by radiologist and histopathological size or 1D measurement by CAE and histopathological size was assessed using the Bland-Altman method. For chemotherapy monitoring, we evaluated @entity5 response through the change in the 1D diameter by a radiologist and CAE and three-dimensional (3D) volumetric change by CAE based on Response Evaluation Criteria in @entity5 (RECIST). Agreement between the 1D response by the radiologist versus the 1D response by CAE as well as by the 3D response by CAE were evaluated using weighted kappa (k) statistics. RESULTS: For the assessment of @entity41 extent after chemotherapy, the mean @entity5 diameter measured by radiologists (2.0    1.7 cm) was significantly smaller than the mean histological diameter (2.6    2.3 cm) (p = 0.01), whereas, no significant difference was found between the CAE measurements (mean = 2.2    2.0 cm) and histological diameter (p = 0.19). The mean difference between the 1D measurement by the radiologist and histopathology was 0.6 cm (95% confidence interval: -3.0, 4.3), whereas the difference between CAE and histopathology was 0.4 cm (95% confidence interval: -3.9, 4.7). For the monitoring of response to chemotherapy, the 1D measurement by the radiologist and CAE showed a fair agreement (k = 0.358), while the 1D measurement by the radiologist and 3D measurement by CAE showed poor agreement (k = 0.106). CONCLUSION: CAE for breast MRI is sufficiently accurate for the assessment of @entity41 extent in @entity0 @entity1 receiving neoadjuvant chemotherapy. However, for the assessment of response to chemotherapy, the assessment by the radiologist and CAE showed a fair to poor agreement.
