Selected growth factors in peritoneal dialysis: their relationship to markers of @entity32 , dialysis adequacy, XXXX , and peritoneal membrane transport.

@entity1 @entity32 @entity650 @entity454 @entity7 @entity177 @entity540 @entity2533 @entity1011 @entity298 @entity1851
OBJECTIVES: Markers of @entity32 , acute-phase reactants, and growth factors may be concomitantly involved in a number of pathologic processes in the general population and uremic @entity1 . In addition, growth factors may influence peritoneal membrane transport characteristics. However, the association between plasma growth factors, markers of @entity32 , and peritoneal membrane transport remains largely unknown. The aim of this study was to evaluate the relationship between plasma levels of selected growth factors [ @entity540 ( @entity540 ), @entity2533 ( @entity2533 ), @entity7 ( @entity7 )] and markers of @entity32 [ @entity650 , @entity1851 ( @entity1851 ), and fibrinogen] in continuous ambulatory peritoneal dialysis (CAPD) @entity1 . The potential link between the above substances and dialysis adequacy was also explored. DESIGN: Single-center, cross-sectional study. SETTING: Peritoneal Dialysis Unit, Medical Faculty, Jagiellonian University Hospital, Krak  w, Poland. @entity1 : 32 stable @entity454 @entity1 (13 M, 19 F; mean age 53.6 +/- 13.7 years) on CAPD for a median period of 19.5 months. @entity1 free from signs and symptoms of any @entity32 (including @entity298 ) for at least 3 months were included into the study. All @entity1 underwent measurements of dialysis dose [Kt/V, weekly @entity1011 clearance (wCCr)] and peritoneal solute transport using a standard peritoneal equilibration test (PET). METHODS: @entity2533 , @entity540 , @entity7 , and @entity650 were measured with ELISA, @entity1851 was assayed with immunonephelometry, and fibrinogen with Multifibren U reagent (Dade Behring Marburg GmbH, Marburg, Germany). Nephron 97 for Windows software was used to assess dialysis adequacy. RESULTS: Significant positive correlations between plasma @entity540 and @entity650 , as well as fibrinogen concentrations (R = 0.36, p < 0.05 and R = 0.39, p < 0.05, respectively), were found. @entity7 correlated significantly with @entity650 and @entity1851 (R = 0.65, p < 0.0001 and R = 0.51, p < 0.005, respectively). An association between @entity7 and @entity540 was also found (R = 0.59, p < 0.0005). Serum level of @entity2533 revealed no relationship with any marker of acute-phase activation, remaining growth factors, or dialysis adequacy. Positive correlation between @entity2533 concentration and dialysate-to-plasma ratio for @entity1011 in PET (R = 0.35, p < 0.05) was found. In addition, @entity1 with lower solute transport (low/low-average transporters) had lower serum levels of both @entity540 and @entity2533 compared to @entity1 with higher solute transport. @entity1 with total wCCr > 60 L/ week/m2 were characterized by lower levels of @entity540 and @entity650 . Serum level of @entity650 and plasma levels of @entity540 and @entity7 were significantly lower among subjects with @entity177 ( @entity177 ) > 2.0 mL/minute. CONCLUSIONS: Our results indicate that systemic @entity32 in peritoneal dialysis @entity1 is associated with increased plasma @entity7 and @entity540 but not @entity2533 . The negative correlation with @entity177 suggests that either the renal clearance of these cytokines and growth factors may contribute to their elimination, or cytokines and growth factors have a negative impact on @entity177 . We also suggest an association between serum levels of growth factors tested and peritoneal membrane function.
