Anti-Outer membrane protein C antibodies in XXXX .

@entity1 @entity2513 @entity14
UNASSIGNED: Sporadic @entity14 ( @entity14 ) represents an enormous problem worldwide. Large intestinal microbiota play an important role in the @entity14 . The aim of the study was to investigate anti-Outer membrane protein C (anti-OmpC) antibodies, aimed at porin C, which is embedded in the outer membrane of gram-negative bacteria, in @entity1 with @entity2513 ( @entity2513 ), @entity14 and controls. The study included 22 @entity1 with @entity2513 (11 @entity1 , 11 @entity1 , aged 26-79, mean 65        12), 11 @entity1 with @entity14 (9 @entity1 , 2 @entity1 , aged 50-83, mean 66        11) and 45 controls, blood donors (24 @entity1 , 21 @entity1 , aged 20-58, mean 38        10). Serum anti-OmpC antibodies were investigated by means of ELISA. Values of 0-20  U/mL were considered to be negative; values >25  U/mL were assessed as positive. A total of 9/11 (82  %) @entity1 with @entity14 had positive anti-OmpC antibodies. Anti-OmpC antibodies were negative or grey-zone in 37/45 (82  %) controls. Serum anti-OmpC were found to be significantly higher in @entity1 with @entity14 (median 42.4, interquartile range (IQR) 22.2) compared to controls (median 18.3, IQR 12.4), p   <   0.001. No statistically significant difference in anti-OmpC was found between controls (median 18.3, IQR 12.4) and @entity2513 @entity1 (median 17.7, IQR 16.5), p   =   0.326. Anti-OmpC were significantly higher in @entity1 with @entity14 (median 42.4, IQR 22.2) compared to @entity1 with @entity2513 (median 17.7, IQR 16.5), p   =   0.011. Positivity of anti-OmpC antibodies was found in @entity1 with @entity14 , which supports the contribution of gram-negative large intestinal microbiota to the pathogenesis of @entity14 .
