XXXX in a once-a-day step-3 antihypertensive program.

@entity1 @entity101 @entity2294 @entity12737 @entity5491 @entity5894 @entity9804
Convenience of medicine-taking and lack of side effects are two major factors that favor compliance. Using a simple and convenient once-a-day regimen of @entity5491 , @entity5894 , and @entity9804 , we treated successfully 30 @entity1 with moderate to severe @entity101 . All @entity1 were previously taking at least three medications, usually three to four times a day. Treatment was started with @entity5894 (160 mg) and @entity9804 (50 mg) once daily. If diastolic blood pressure remained above 90 mmHg, @entity5491 was added at a starting dose of 2.5 mg/day and increased weekly until blood pressure was controlled or the maximum dose of 100 mg/day was reached. The average blood pressure decreased from 170.9/107.0 mmHg (sitting) and 174.1/110.8 mmHg (standing), before the addition of @entity5491 , to 138.8/86.7 mmHg (sitting) and 140.0/89.5 mmHg (standing), at the third month of @entity5491 therapy. At the sixth month of @entity5491 therapy, the figures were 140.9/86.3 and 141.9/89.8 mmHg. With this single-dose program, smooth blood pressure control throughout 24 hours was documented by 24-hour ambulatory blood-pressure monitoring. @entity12737 was common but was bothersome only to @entity1 @entity1 . @entity2294 occurred in five @entity1 , but they were all small and asymptomatic. Subjective side effects of the regimen were usually so mild that all @entity1 who completed the study decided to remain on the same regimen.
