Responsiveness, Minimal Detectable Change, and Minimally Clinically Important Differences for the XXXX Scale.

@entity1 @entity131 @entity14421 @entity772 @entity1662 @entity922
OBJECTIVES: To determine the responsiveness, minimal detectable change (MDC95), and @entity922 ( @entity922 ) of the @entity1662 Scale (DOCS-25) in @entity1 with severe @entity131 ( @entity131 ) and to report the percentages of @entity1 ' change scores exceeding @entity14421 and @entity922 after 3 weeks of inpatient rehabilitation. SETTING: Post-acute rehabilitation hospitals. @entity1 : One hundred seventy-two @entity1 with severe @entity131 . Ninety-two were included in the DOCS-25 3-week analysis. DESIGN: Retrospective cohort study. MAIN MEASURE(S): @entity1662 Scale, Glasgow @entity772 Scale. RESULTS: The effect size and standardized response mean of the DOCS-25 for those who improved were 0.45 and 1.3, respectively-moderate to large by Cohen criteria. The MDC95 (95% confidence interval) was 5.6. Distribution-based MCIDs for small (0.20 SD), moderate (0.33 SD), and large (0.50 SD) differences were 2.6 units, 4.4 units, and 6.6 units, respectively. The anchor-based @entity922 was 8.6 units. On average, @entity1 who improved (n = 57) gained 14.5 units by week 3, exceeding the anchor-based @entity922 . On average, @entity1 who did not improve (n = 35) declined by 7.2 units, which exceeds both the MDC95 and the largest distribution-based @entity922 . CONCLUSION(S): The DOCS-25 is a responsive, clinician-observed assessment tool for capturing change in neurobehavioral function in adults recovering from severe @entity131 . This is the first study to provide evidence for the size of neurobehavioral function change that might indicate meaningful recovery in @entity1 with severe @entity131 . Results from this study may support future research by better informing sample size calculations for clinical trials and also assist clinicians in identifying when variation in level of consciousness is consequential enough to warrant changes in intervention.
