Clinical relevance of TNM staging system according to XXXX subtypes.

@entity1 @entity4557 @entity0 @entity5 @entity1722
BACKGROUND: There has been reported that the association between nodal spread and @entity5 size was disrupted in @entity0 ( @entity0 ) and it showed characteristically early relapse. The TNM ( @entity5 -node-metastasis) staging system might not be equally effective as a prognostic indicator for all subtypes. The aim of our study was to evaluate the usefulness of the staging according to subtypes. @entity1 AND METHODS: We conducted a retrospective analysis of invasive @entity0 @entity1 who received curative surgery at Samsung Medical Center from 2000 to 2004. @entity4557 ( @entity4557 ) by stage were analyzed. RESULTS: Thousand eight hundred and seventy-nine @entity1 who were available clinicopathologic data were included. These @entity1 were divided into three subtypes: hormone receptor (HR)+, @entity1 epidermal growth factor receptor 2+, and triple negative groups. As the stage became more advanced, the slope of each stage of the @entity4557 curves of @entity1 with HR+ and @entity1722 + steadily increased. In contrast, @entity4557 curves intermingled and showed overlap from stage 1 to 3A in @entity0 @entity1 . There was only wide separation of @entity4557 curves between stage 1-3A and 3B-3C in @entity0 . CONCLUSIONS: The current TNM staging system might not be enough for encompassing the @entity5 biology and for predicting outcomes to make therapeutic decisions for all BCs, especially for @entity0 @entity1 .
