Salvage radical prostatectomy for XXXX : verification of European Association of Urology guideline criteria.

@entity1 @entity263 @entity5 @entity3
OBJECTIVE: To analyse oncological and functional outcomes of salvage radical prostatectomy (SRP) in @entity1 with @entity263 and to compare outcomes of @entity1 within and outside the European Association of Urology (EAU) guideline criteria (organ-confined @entity263  <=T2b, Gleason score  <=7 and preoperative PSA level <10  ng/mL) for SRP. @entity1 AND METHODS: In all, 55 @entity1 who underwent SRP from January 2007 to December 2012 were retrospectively analysed. Kaplan-Meier curves assessed time to biochemical recurrence (BCR), @entity3 ( @entity3 ) and @entity5 -specific survival. Cox regressions addressed factors influencing BCR and @entity3 . BCR was defined as a PSA level of >0.2  ng/mL and rising, continence as the use of 0-1 safety pad/day, and potency as a five-item version of the International Index of Erectile Function score of >= 18. RESULTS: The median follow-up was 36  months. After SRP, 42.0% of the @entity1 experienced BCR, 15.9% developed @entity3 , and 5.5% died from @entity263 . @entity1 fulfilling the EAU guideline criteria were less likely to have positive lymph nodes (LNs) and had significantly better BCR-free survival (5-year BCR-free survival 73.9% vs 11.6%; P = 0.001). In multivariate analysis, low-dose-rate brachytherapy as primary treatment (P = 0.03) and presence of positive LNs at SRP (P  = 0.02) were significantly associated with worse BCR-free survival. The presence of positive LNs or Gleason score >7 at SRP were independently associated with @entity3 . The urinary continence rate at 1  year after SRP was 74%. Seven @entity1 (12.7%) had complications >= III (Clavien grade). CONCLUSION: SRP is a safe procedure providing @entity5 control and reasonable urinary continence. Oncological outcomes are significantly better in @entity1 who met the EAU guideline recommendations.
