@entity4779 inhibition in normocapnic and hypercapnic contracting XXXX soleus.

@entity3884 @entity2944 @entity54770 @entity19 @entity3791 @entity26 @entity4779 @entity544 @entity2701 @entity121
The physiological role of @entity4779 in @entity121 was investigated using isolated @entity19 soleus (N = 30) contracting once every 1.7 min for 75 min in Krebs-Henseleit solution gassed with either 95% @entity26 - 5% @entity544 (normocapnia) or 90% @entity26 - 10% @entity544 ( @entity2944 ). Each contraction was 500 ms in duration at 50 Hz. When muscles contracted in normocapnic solution (pH 7.42), the developed @entity2701 decreased an average of 6.1 +/- 0.8% over 25 min. For the next 50 min, 15 muscles remained normocapnic, while the remainder contracted in hypercapnic solution (pH 7.20). Tension decreased significantly more with @entity2944 . For the last 25 min, both normocapnic and hypercapnic muscles were divided into three treatment groups (N = 5). One group continued in the same environment, while @entity3791 (final concentration of 10(-5) M) was added to the bath of the second and @entity54770 (final concentration of 10(-5) M) was added to the bath of the third group. @entity3791 had no effect on @entity2701 in either @entity544 environment. @entity54770 significantly decreased @entity2701 from the hypercapnic control but had no effect in normocapnia. Thus @entity4779 inhibition with @entity54770 increased the effect of @entity2944 implying that @entity4779 assists in the regulation of free @entity3884 ion concentration in @entity121 .
