Primary @entity2239 -eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of XXXX .

@entity1 @entity63 @entity256 @entity2239 @entity661
PURPOSE: To report the long-term outcomes of a single-center prospective study investigating primary placement of @entity2239 -eluting metal stents for recanalization of long infrapopliteal lesions compared to a matched historical control group treated with @entity661 and provisional placement of bare metal stents in a bailout manner. METHODS: The study included 81 @entity1 (63 @entity1 ; mean age 71 years, range 45-85) suffering from @entity63 ( @entity63 ) and angiographically proven long-segment (at least 1 lesion >4.5 cm) de novo infrapopliteal artery disease who underwent below-the-knee revascularization with either primary placement of @entity2239 -eluting stents (n = 47, 51 limbs, 102 lesions) or angioplasty and bailout bare metal stenting (n = 34, 36 limbs, 72 lesions). Clinical and angiographic follow-up was collected at regular time intervals. Primary clinical and angiographic endpoints included @entity1 survival, major amputation-free survival, angiographic primary patency, @entity256 (>50%), and overall event-free survival. Results were stratified according to endovascular treatment received. Multivariable Cox proportional hazards regression analysis was applied to adjust for confounding factors of heterogeneity. RESULTS: Baseline demographics were well matched. No significant differences were identified between the 2 groups with regard to overall 3-year @entity1 survival (82.2% versus 65.7%; p = 0.90) and amputation-free survival (77.1% versus 86.9%; p = 0.20). Up to 3 years, lesions fully covered with @entity2239 -eluting stents were associated with significantly higher primary patency [hazard ratio (HR) 7.98, 95% CI 3.69 to 17.25, p < 0.0001], reduced binary restenosis (HR 2.94, 95% CI 1.74 to 4.99, p < 0.0001), and improved overall event-free survival (HR 2.19, 95% CI 1.16 to 4.13, p = 0.015) versus the matched historical control group. CONCLUSION: Primary infrapopliteal @entity2239 -eluting stenting for @entity63 treatment significantly inhibits restenosis and improves long-term angiographic patency and overall @entity1 event-free survival compared to balloon angioplasty and bailout bare metal stenting.
