Report: Central nervous system (CNS) toxicity caused by metal XXXX : Brain as a target organ.

@entity1 @entity2167 @entity1313 @entity349 @entity16 @entity95 @entity4968 @entity3409 @entity74 @entity2359
UNASSIGNED: @entity1 relate the @entity2167 with either @entity74 but there might be some other reasons responsible for the ailment of @entity1 that do not have such a background. The present study explains the chronic effect of heavy toxic metals on nervous system. During experimentation, @entity95 used as laboratory animals, were given test metals in their diet. Concentration of metals given to them in the diet was less than their tolerable dietary intake. Behavioral changes were observed during experimentation. Periodic increase in the metal concentration was seen in the blood sample of @entity95 . They were slaughtered after a period of eight months of slow @entity4968 . Histological examination of brain tissues was performed. The brain samples were analyzed by Atomic absorption spectroscopy and Inductively Coupled Plasma Mass Spectrometry to find the retention of heavy metals in @entity1 brain. Concentration of lead, @entity349 and @entity3409 in the blood samples of occupationally exposed @entity1 and @entity1 with @entity16 at the time of neurosurgery was determined by using the same techniques. During circulation, toxic metals passes through the nerve capillaries to settle down in the brain. Heavy metals cross the blood brain barrier and 'may retain themselves in it. @entity1313 and biopsy samples of @entity1 with @entity16 were also analyzed to relate @entity2359 and heavy metal @entity4968 . Results obtained shows that lead, @entity349 and @entity3409 retain themselves in the brain for longer period of time and are one of the causes of @entity2359 .
