XXXX : physical and cardiovascular deconditioning.

@entity1 @entity1674 @entity1391 @entity5815 @entity165
We investigated whether @entity5815 ( @entity5815 ) @entity1 have physical and/or cardiovascular de-conditioning, in 273 @entity5815 @entity1 and 72 healthy controls. We used laboratory tests to assess haematological, biochemical, endocrinological and immunological systems. The cardiovascular system was assessed by echocardiography and carotid echography. Body composition was determined by dual energy X-ray absorptiometry (DEXA). @entity5815 @entity1 had smaller left ventricular end systolic (p < 0.001) and diastolic (p = 0.008) dimensions but thinner posterior walls (p = 0.02) than corresponding values in healthy controls. Left ventricular mass was also reduced in @entity5815 @entity1 (p = 0.006). Both maximum (p < 0.001) and minimum (p < 0.008) diameter of the carotid artery were smaller in @entity5815 @entity1 . The laboratory screening tests showed significant differences in serum albumin (p = 0.05), @entity1391 (p = 0.02), HDL- @entity165 (p = 0.03), HDL:total @entity165 ratio (p = 0.01), @entity1674 (p = 0.02), neutrophils (p = 0.01) and thyroid-stimulating hormone (p = 0.04) between @entity5815 @entity1 and controls. Male @entity5815 @entity1 had an increased percentage of fat mass compared with healthy male subjects (p = 0.02). This large group of @entity5815 @entity1 had evidence of physical and cardiovascular de-conditioning, suggesting that in these @entity1 a graded exercise programme could lead to physical reconditioning and could increase their ability to perform physical activities.
