Mesenchymal stem cells ameliorate tissue damages triggered by XXXX and @entity5721 .

@entity32 @entity8 @entity5721 @entity1133 @entity63 @entity19 @entity635 @entity4698 @entity810 @entity1011
BACKGROUND: @entity63 and @entity5721 (I/R) is the major cause of @entity810 ( @entity810 ) with high mortality rates. Because alternative therapies are needed, we investigated the use of stem cell therapy to modulate @entity32 in a renal I/R model. METHODS: To study kidney I/R injury, we clamped bilateral pedicles for 60 minutes. Mesenchymal stem cells (MSC), which had been isolated and cultivated in plastic flasks, were administered to @entity19 6 hours after injury. Real-time polymerase chain reaction was used to quantify interleukin (IL)-4 and @entity635 mRNAs. Proliferative nuclear cell antigen ( @entity4698 ) was used to calculate tubular regeneration. RESULTS: Administration of MSC attenuated @entity8 ; serum @entity1011 and plasma @entity1133 levels were significantly reduced 24 hours after reperfusion. @entity4698 immunohistochemistry showed that regeneration occurred faster in renal tissues of animals that received MSC than in tissues of control animals. Analyses of cytokine expression in renal tissue demonstrated a greater level of anti-inflammatory cytokines in MSC-treated animals. CONCLUSION: These results showed an antiinflammatory pattern in MSC-treated animals, demonstrating the potential of MSC to modulate I/R, leading to earlier regeneration of damaged renal tissue.
