Weight cycling and the risk of type 2 XXXX in the EPIC-Germany cohort.

@entity1017 @entity353 @entity6
AIMS/HYPOTHESIS: Studies on @entity353 and the risk of type 2 @entity6 have revealed inconsistent results, possibly due to differences in the definition of weight fluctuations. Here, we investigated whether @entity353 during adulthood is related to @entity6 risk in a large cohort study, using a complementary approach to define patterns of weight development. METHODS: Weight cycling, @entity353 and @entity1017 were defined (1) a priori, using distinct categories, and (2) by functional principal component analysis (FPCA) to capture weight patterns in greater detail. Associations of @entity353 , @entity353 and @entity1017 with the risk of type 2 @entity6 were evaluated by Cox regression models. RESULTS: A priori defined @entity353 was associated with increased @entity6 risk, compared with stable weight (HR 1.36 [95% CI 1.09, 1.68]). No significant association between FPCA-derived @entity353 and risk of @entity6 was observed after adjustment for concurrent weight patterns (HR 1.19 [95% CI 0.89, 1.60]). Subgroup analyses showed that FPCA-derived @entity353 during net @entity1017 was associated with a higher risk of @entity6 (HR 1.68 [95% CI 1.14, 2.48]). A priori defined @entity1017 (HR 2.08 [95% CI 1.60, 2.70]) was more clearly related to the risk of @entity6 than FPCA-derived @entity1017 (HR 1.20 [95% CI 0.95, 1.51]), while no significant associations were observed for @entity353 . CONCLUSIONS/INTERPRETATION: Overall, @entity353 may not be an independent risk factor for type 2 @entity6 when accounting for concurrent patterns of weight development. However, @entity353 may pose a stronger risk of @entity6 than non-cycling during net @entity1017 .
