Autoimmune Conditions in 235 XXXX Probands with HFE C282Y Homozygosity and Their First-Degree Relatives.

@entity1 @entity82 @entity753 @entity6571 @entity6 @entity68 @entity4107 @entity2621 @entity1068 @entity1691 @entity1561 @entity99 @entity792 @entity309 @entity9595
We performed a retrospective study of autoimmune conditions (ACs) in 235 @entity9595 probands at diagnosis by analyzing age, sex, ACs, history of first-degree @entity792 ( @entity753 ), @entity6 , heavy @entity1068 consumption, elevated serum ALT/ @entity6571 , @entity1561 , @entity99 , @entity82 , @entity68 removed to achieve @entity68 depletion (QFe), and positivity for human @entity4107 haplotypes A (   ) 01, B (   ) 08; A (   ) 02, B (   ) 44; A (   ) 03, B (   ) 07; A (   ) 03, B (   ) 14; and A (   ) 29, B (   ) 44. There were 138 @entity1 (58.7%). Median followup was 19.6   y. One or more of 19 ACs were diagnosed in each of 35 probands (14.9%). Prevalences of @entity2621 , @entity309 , and @entity1691 were 8.1% (95% CI: [5.1, 12.5]), 1.7% [0.6, 4.6], and 0.0085 [0.0015, 0.0337], respectively. Eighteen probands (7.7%) had a @entity753 . Eight probands with ACs had 9 @entity792 . In a logistic regression, ACs were less likely in @entity1 (odds ratio (OR) 0.3 [0.1, 0.6]) and more likely in probands with a @entity753 (OR 4.1 [1.4, 11.8]). Overall ACs risk was not significantly associated with QFe or @entity4107 haplotypes. Estimated survival of probands with and without ACs did not differ significantly. We conclude that ACs are common in @entity9595 probands, especially @entity1 and probands with a @entity753 .
