@entity4310 in XXXX is not a prognostic factor?

@entity1 @entity5 @entity0 @entity4310
The aim of this study is to determine if breast conservative treatment is justified for @entity1 with a positive family history of @entity0 and to investigate whether they have a worse prognosis. We performed a prospective cohort study of @entity0 @entity1 , treated with breast conservative treatment with radiotherapy at the Radiotherapy Department of the Medisch Spectrum Twente. Between 1984 and 1996, 1204 @entity1 with T1 and T2 < or =3 cm were treated. @entity4310 ( @entity4310 ) was recorded according to first degree relative (FDR). Treatment consisted of lumpectomy with axillary dissection followed by radiotherapy to the whole breast with a boost to the primary area. Adjuvant systemic therapy was given to @entity1 with positive nodes. A positive @entity4310 was noted in 243 (20.5%) @entity1 , of whom 208 (17.6%) had one FDR, and 35 (3.0%) > or =2 FDRs. The local recurrence rate was 4.1%, with similar rates for all groups. In young @entity1 , < or =40 years, a significant relation between local recurrence and @entity4310 was found. The distant metastasis rate was 15.5%, with the lowest rate (5.7%) among @entity1 with > or =2 FDRs. @entity1 with a positive @entity4310 had significantly more @entity5 . The 5-year corrected survival was 91.3%. Among @entity1 with a positive @entity4310 , a 5-year corrected survival of 91% was observed and the survival 100% among @entity1 with one and > or =2 FDR. @entity4310 is not a contraindication for breast conservative treatment and is not associated with a worse prognosis. @entity4310 is not a prognostic factor for local recurrence rate in @entity1 older than 40 years.
