Recreational exercise and quality of life among XXXX undergoing adjuvant chemotherapy for @entity0 .

@entity1 @entity632 @entity137 @entity0 @entity1295 @entity786 @entity1311 @entity1499 @entity1487
UNASSIGNED: 8195 Background: The negative relationship between exercise and treatment-related @entity137 in @entity1 with @entity0 was first noted in the mid-1980s. Since then a number of randomized studies have demonstrated the benefits of exercise during adjuvant therapy for @entity0 with respect to @entity1295 , functional ability, and quality of life (QOL). In order to further characterize this relationship we have conducted a study examining the impact of exercise on chemotherapy-related @entity137 and QOL. METHODS: A cohort of forty @entity1 completed a modified Godin and FACT-B QOL questionnaire at the beginning, midpoint, and end of treatment with adjuvant chemotherapy. Additional outcomes were @entity137 , use of growth factors, treatment delay, and hospitalizations. @entity137 was evaluated and analyzed both by grade and by type based on the most common @entity137 encountered. RESULTS: There was no statistically significant correlation between exercise intensity and QOL, @entity137 , or the requirement for growth factors, treatment delays, or hospitalization, both when the data was and was not stratified by chemotherapy regimen. Interestingly, when the @entity1 ' average QOL scores were correlated with the same variables, no statistically significant correlation was found. However, QOL was significantly lower for those @entity1 receiving chemotherapy regimens consisting of @entity632 , @entity786 , and @entity1311 (in any order) than those receiving @entity786 , @entity1499 , and @entity1487 (p=0.0164). CONCLUSIONS: The results of this cohort study do not implicate a role for exercise in the diminution of chemotherapy-related @entity137 nor the improvement of QOL for @entity0 @entity1 undergoing adjuvant chemotherapy. However, this study was limited by design and @entity1 numbers. That it failed to identify a difference in QOL among the @entity1 who experienced the most severe @entity137 , and those who required growth factors, treatment delays, or hospitalization suggests that it was not powerful enough to detect such differences among @entity1 who engaged in different exercise intensities. No significant financial relationships to disclose.
