News on Biomarkers in XXXX .

@entity1 @entity5272 @entity8 @entity2067 @entity3528 @entity740 @entity9198 @entity79 @entity2331 @entity461 @entity74 @entity2221 @entity413 @entity65 @entity2159
UNASSIGNED: The increased awareness of the potential role played by @entity79 in the appearance of @entity65 in renal @entity1 has produced research efforts aimed at discovering possible pathogenic links. Accordingly, the diagnostic significance of the classic bone markers of @entity74 and of the new markers in the setting of @entity740 ( @entity740 ) needs to be re-evaluated along with increasing information. In this article we include @entity2331 and some of the noncollagenous bone proteins that are gaining experimental and clinical significance in @entity740 . Among classic markers of @entity3528 and of @entity8 , we analyzed @entity461 , alkaline phosphatase, @entity5272 -resistant acid phosphatase, and bone collagen-derived peptides. We underlined, for each, the relevance of parent proteins (peptides or isoforms) that affect assay methods and, eventually, the diagnostic or prognostic significance. Also, we considered their relationship with @entity65 . Among the numerous noncollagenous bone proteins, we examined @entity9198 ( @entity9198 ), osteocalcin (OC), @entity2159 , and the small integrin-binding ligand N-linked glycoprotein family. For @entity9198 and OC we report the relevant involvement with the process of calcification ( @entity9198 ) and with @entity413 and energy metabolism (OC). Both of these proteins require @entity2067 to become active and this is a specific problem in renal @entity1 who frequently are deficient of this @entity2221 . Finally, recent acquisitions on the fascinating family of the small integrin-binding ligand N-linked glycoprotein proteins are recapitulated briefly to underline their potential clinical interest and their complex involvement with all aspects of @entity740 . Their diagnostic role in clinical practice awaits further studies.
