Overall survival after pelvic exenteration for gynecologic XXXX .

@entity5 @entity1 @entity204 @entity1349
BACKGROUND: Five-Year survival after pelvic exenteration for gynecologic @entity5 has been reported as high as 60%. The objective of this study was to determine @entity1349 ( @entity1349 ) after pelvic exenteration and evaluate factors impacting outcome. METHODS: A retrospective review of all @entity1 who underwent pelvic exenteration at our institution between February 1993 and December 2010 was performed. @entity1349 was defined as time from exenteration to date of @entity204 or last contact. Survival analysis was performed using the Kaplan Meyer method. Multivariate analysis was performed to determine the impact of clinical and pathologic factors on survival outcomes. RESULTS: One hundred sixty @entity1 with gynecologic @entity5 underwent pelvic exenteration. Five-year @entity1349 ( @entity1349 ) was 33% (95%CI 0.25-0.40). Factors which negatively impacted @entity1349 included shorter treatment-free interval (p=.050), vulvar primary (p=.032), positive margins (p<.001), lymphovascular space invasion (LVSI, p<.001), positive lymph nodes (p<.001) and perineural invasion (p=0.030). In multivariate analysis, positive margins (p=.040), positive nodes (p<.001) and lymphovascular space invasion (LVSI, p=.003) retained a significant impact on @entity1349 . Five-year @entity1349 was 40% (95% CI 0.32-0.48). Factors which negatively impacted @entity1349 included vulvar primary (p=.04), positive margins (p<.001), LVSI (p<.001), positive lymph nodes (p<.001) and perineural invasion (p=.008). In multivariate analysis, positive nodes (p=.001) and LVSI (p=.001) retained a significant impact on @entity1349 . CONCLUSION: Five-year @entity1349 after pelvic exenteration was 40%. Survival outcomes have not significantly improved despite improvements in technique and @entity1 selection. Multiple non-modifiable factors at the time of exenteration are associated with poor survival.
