Under-reporting of venous and arterial XXXX events in @entity922 : a meta-analysis.

@entity1 @entity32 @entity137 @entity5 @entity715 @entity1211 @entity65 @entity922
UNASSIGNED: For the detection of unwanted outcomes of new interventions, physicians rely on adverse event reporting. We attempt to quantify the reported incidence of @entity1211 ( @entity1211 ) and @entity715 ( @entity715 ) in @entity922 ( @entity922 ), and evaluate the extent of under-reporting. We selected all therapeutic @entity922 published in the four highest-impact general medicine journals between January 2011 and July 2011. @entity1 were categorized according to @entity1211 risk. The occurrences of @entity1211 and @entity715 , either as predefined outcome or adverse event, were assessed. We identified 131 @entity922 . @entity1211 and @entity715 were not reported in 89 and 70  % of these studies, respectively. The raw-unweighted reported incidence in the 3 studies with predefined outcomes for @entity1211 was 8.4 (7.8-9.1) per 1,000  @entity1 -years. In the 128 studies without predefined outcomes for @entity1211 , (consisting of 322,029 individuals, including @entity1 with @entity5 , @entity32 , @entity65 , surgery, adding up to a follow-up >500,000 @entity1 -years), an incidence of 0.4 (0.4-0.5) per 1,000 @entity1 -years was found. The reported incidence of @entity715 in 18 studies in which @entity715 was part of predefined outcomes was 25.6 (24.9-26.3) per 1,000 @entity1 -years. In 92 studies without predefined outcomes for @entity715 (231,638 individuals, follow-up >200,000  @entity1 -years,), the incidence was 2.5 (2.3-2.7) per 1,000  @entity1 -years. The incidence of @entity1211 and @entity715 in @entity922 is highly under-reported. Uniform registration of adverse events, even when unlikely to be related to the intervention, is necessary to be able to inform physicians about the potential @entity137 of new therapeutic strategies.
