Pattern of XXXX in offspring of chronic alcoholic mothers.

@entity1 @entity851 @entity137 @entity988 @entity245 @entity299 @entity600 @entity1017 @entity4242 @entity3573 @entity1068 @entity65
Case histories are presented of 8 unrelated @entity1 born to mothers who were chronic alcoholics. These @entity1 showed a similar pattern of craniofacial, limb, and @entity65 associated with prenatal-onset @entity851 and @entity245 . This is the 1st report to document an association between maternal @entity988 and aberrant morphogenesis in the offspring. The mean duration of maternal @entity988 was 9.4 years. 3 of the cases were black, 3 were Native American, and 2 were white. The mean gestational age was 38 weeks. The degree of @entity851 was more severe than the deficit of weight at birth, suggesting that a factor other than maternal undernutrition alone affected prenatal growth. @entity851 , and short palbebral fissures were observed in all 8 @entity1 . 7 of the 8 @entity1 also demonstrated @entity4242 and @entity3573 with relative prognathism. 6 had an altered palmar crease pattern, 5 showed @entity299 , and 4 had epicanthal folds. Although adequate nutrition was provided to the @entity1 during hospital admission and/or foster care placement, no catch-up growth was observed. After 1 year, the average linear growth rate was 65% of normal and the average rate of @entity1017 was only 38% of normal. By 1 year, head circumference fell below the 3rd percentile for height and chronological age in 5 of the 6 @entity1 in whom measurements were taken. Fine motor dysfunction was present in 5 of the 6 @entity1 tested, and most were delayed in gross motor performance as well. The similarity in pattern of @entity600 noted among these 8 @entity1 suggests a singular mode of etiology related to an as yet unknown effect of maternal @entity988 . Direct @entity1068 @entity137 is the most likely possibility.
