Treatment patterns with systemic antipsoriatic agents in childhood XXXX : an Italian database analysis.

@entity1 @entity14028 @entity1569 @entity205 @entity1499
BACKGROUND: Most of systemic therapies have not been systematically investigated in moderate to severe @entity1569 . Treatment preferences for moderate to severe @entity1569 in childhood are unknown. OBJECTIVE: the objectives of this study were to investigate the systemic treatment patterns of moderate to severe @entity1569 in @entity1 and adolescents aged  <= 18 years in Italy. Additional secondary outcomes were duration of treatment and reasons for discontinuation. METHODS: to define differences in treatment patterns, we performed a chart review of all consecutive @entity1 treated with systemic drugs during an index period of five years. Consecutive sampling of all @entity1 with @entity1569 , aged  <= 18 years, who had been treated with at least one systemic drug over a 5-year period, was made. RESULTS: the records of 58 consecutive @entity1 , 27 males, 31 females. with moderate to severe @entity1569 treated with at least one systemic therapy were reviewed. The median age (standard deviation) at the start of the first systemic treatment was 11.7 years (   3.7). The most preferred first line systemic treatment was @entity205 , which was administered as first systemic treatment in 53.4% of @entity1 , followed by @entity14028 in 22.4% of @entity1 , etanercept and PUVA respectively in 8.6%, @entity1499 in 6.8%. 48.2% of @entity1 received a second systemic treatment due to inefficacy or side effects of the first line therapy during the index period. Because of the small sample, and voluntary contribution, selection bias may have occurred. CONCLUSION: a considerable variation in the management of the first line systemic therapy in @entity1 with moderate to severe @entity1569 was observed. @entity205 was most commonly preferred as a first-line treatment. The availability of new therapeutic agents could change the scenario of treatment patterns in childhood @entity1569 .
