Eosinophilic inclusions in XXXX represent microlumina: a light and electron microscopic study.

@entity1712 @entity424 @entity1326 @entity5 @entity1325 @entity2281
A study was undertaken to determine the pathological significance of previously unrecognized @entity1712 ( @entity1712 ) in @entity424 . The study group consisted of 58 @entity424 , all of which were pathologically characterized and graded according to the 1993 WHO classification. Electron microscopic studies were performed in 16 cases. The study showed that 33 (57%) @entity424 had @entity1712 and that in 8 cases these were abundant. Round and eosinophilic, their sizes varied from 10 microns to a tiny dot. Similar eosinophilic bodies were also observed between @entity5 cells. The inclusions were weakly PAS positive. On immunostains, @entity1712 were frequently positive for glial fibrillary acidic protein, less often for @entity2281 protein, and for epithelial membrane protein and CAM 5.2. They were negative for @entity1325 / @entity1326 , carcinoembryonic antigen and Ber-EP4. Ultrastructurally, @entity1712 represented intracytoplasmic lumens containing microvilli and cilia. These microlumina also frequently contained granulo-tubular materials. With reference to @entity5 subtypes, @entity1712 occurred most frequently in @entity424 . @entity1712 were also present in 4 of 6 @entity424 studied. In conclusion, @entity1712 represent microlumina and occur in more than a half of @entity424 including malignant examples. Their finding is a helpful diagnostic feature of @entity424 .
