Bone mineral density at various anatomic bone sites in @entity1 receiving combined oral contraceptives and depot- XXXX for contraception.

@entity1 @entity11796 @entity79 @entity134 @entity2586 @entity12135
The association between users of combined oral contraceptives and depot- @entity11796 ( @entity12135 ) for contraception and @entity79 ( @entity79 ) has been controversial because of variations among studies. Like other studies, this cross-sectional study compares @entity79 in users of combined oral contraceptives and @entity12135 with that in nonusers. Unlike previous studies, we defined long-term use as >2 years, and we measured more bone sites than previous studies including lumbar spines, femurs, and forearms. The study group consisted of 59 @entity1 aged 30 years to 34 years who had been using combined oral contraceptives for 57.36 +/- 27.02 months with a minimum period of 24 months, 34 @entity1 of the same age who had been using @entity12135 as contraceptive for 55.76 +/- 35.31 months, and 62 @entity1 of the same age who had not used any @entity134 hormonal contraceptives for more than 6 months. @entity79 was measured by dual energy photon absorptiometer at lumbar spine 2-4, neck of femur, Ward's triangle of femur, greater trochanter of femur, ultradistal radius, and distal ulnar, respectively. Age, body mass index, and lifestyles of both groups were matched with nonusers. Mean @entity79 at lumbar spine ( @entity2586 ) in the @entity12135 users was significantly lower than in the controls (1.031 +/- 0.090 vs. 1.096 +/- 0.116, p = 0.007). There were no significant differences in @entity79 values at bone sites other than lumbar spine between @entity12135 users and the controls. There were no significant differences in @entity79 values at all bone sites between combined oral contraceptives users and the controls. We conclude that combined oral contraceptives are not associated with changes in values of @entity79 , while @entity12135 is associated with decreased @entity79 only at lumbar spine. We comment that @entity134 hormonal contraceptives are safe to use for long-term contraception regarding bone mass effects.
