Serum XXXX in @entity259 and other thyroid disorders.

@entity1 @entity4941 @entity5 @entity189 @entity5651 @entity3745 @entity652 @entity259
Measurements of serum @entity3745 (hTg) were performed using a specific radioimmunoassay. Sera with detectable anti- @entity3745 (anti-Tg) antibody titers (> or = 1:10) as assessed by passive hemagglutination were discarded. Assays were carried out under conditions in which anti-Tg titers less than 1:10 produced no interference. The assay sensitivity was 1.25 ng/ml and the mean +/- SE concentration of serum hTg in 58 control subjects was 9.5 +/- 0.9 ng/ml (range < 1.25-27 ng/ml). A slight but significant (p < 0.025) increase in the mean hTg level was observed in 12 pregnant @entity1 at delivery (25.7 +/- 5.2 ng/ml). Moderate to marked elevations of serum hTg were observed in @entity1 with @entity5651 (61.4 +/- 15 ng/ml; n = 23), @entity4941 (138 +/- 67 ng/ml; n = 5), toxic @entity652 (129 +/- 47 ng/ml; n = 13), untreated (424 +/- 101 ng/ml; n = 35) or treated (328 +/- 222 ng/ml; n = 14) toxic @entity5651 . 88 @entity1 with @entity259 and 10 with @entity5 were studied. The mean level of serum hTg was increased in untreated @entity259 (89.5 +/- 19 ng/ml; n = 13) but not in undifferentiated (10 +/- 2.9 ng/ml; n = 6) or medullary (0.8 +/- 0.2 ng/ml; = 3) @entity189 . In treated @entity259 the mean hTg levels were normal (8.2 +/- 0.2 ng/ml) in @entity1 (n = 24) with no evidence of either a thyroid residue or metastatic disease, moderately increased (56.6 +/- 16 ng/ml) in @entity1 (n = 27) with residual thyroid tissue, markedly elevated in @entity1 with lymph node metastases (199 +/- 50 ng/ml; n = 5) and extremely elevated in those with bone (4004 +/- 982 ng/ml; n = 8) or lung (2520 +/- 620 ng/ml; n = 5) metastases. There was no significant difference in serum hTg between functioning (n = 23) and nonfunctioning (n = 5) metastases as assessed by 131I whole body scan. A slight but significant (p < 0.0005) increase in the mean concentration of hTg was observed in @entity5 (21.7 +/- 4.5 ng/ml; n = 10). Serial measurements showed a transient increase of serum hTg after 131I therapy of @entity259 , toxic @entity5651 or toxic @entity652 , with peak values usually occurring within the first three days. A fall of serum hTg after administration of suppressive doses of thyroid hormone to @entity1 with @entity5651 and a rise after discontinuation of thyroid suppressive therapy in @entity1 with metastatic @entity259 was observed.(ABSTRACT TRUNCATED AT 400 WORDS)
