Neuronal changes after chronic high blood pressure in animal models and its implication for XXXX .

@entity1 @entity101 @entity66 @entity63 @entity303 @entity1294 @entity149 @entity35
@entity1294 is a devastating disorder not only for the @entity1 , but also for the family because this @entity149 breaks the @entity1 's independence, and leads to family care of the @entity1 with a high cost for the family. This complex disorder alters memory, learning, judgment, emotional control and social behavior and affects 4% of the elderly world population. The high blood pressure or arterial @entity101 is a major risk factor for @entity66 , which in most cases leads to @entity1294 . Interestingly, this @entity149 starts after long lasting @entity101 , which is associated with reduced cerebral blood flow or hypoperfusion, and complete or incomplete @entity63 with cortical thickness. Animal models have been generated to elucidate the pathophysiology of this disorder. It is known that dendritic complexity determines the receptive synaptic contacts, and the loss of dendritic spine and arbor stability are strongly associated with @entity303 in @entity1 . This review evaluates relevant data of @entity1 and animal models that have investigated the link between long-lasting arterial @entity101 and neural morphological changes in the context of @entity1294 . We examined the effect of chronic arterial @entity101 and aged in @entity1294 . Neural dendritic morphology in the prefrontal cortex and the dorsal hippocampus and nucleus accumbens after chronic @entity101 was diskussed in the animal models of @entity101 . Chronic @entity101 reduced the dendritic length and spine density in aged @entity35 . Synapse, 2016.    2016 Wiley Periodicals, Inc. Synapse 70:198-205, 2016.    2016 Wiley Periodicals, Inc.
