The effect of unilateral nephrectomy on the nephrotoxicity of @entity3143 in the XXXX .

@entity3143 @entity349 @entity1372 @entity810 @entity35 @entity4434 @entity130
Unilateral nephrectomy (UNX) induces a dramatic change in single-kidney structure and function. Therefore, the effects of nephrotoxins may be altered. To evaluate this possibility, @entity3143 (2 mg/kg, sc) was given to male, @entity35 2 days following either UNX or sham surgery. Nonoliguric @entity810 developed and was qualitatively similar in both groups. Glomerular filtration rate (GFR) reached a nadir on Day 2 and was reduced to a greater extent in the UNX group. Furthermore, recovery of GFR was slower and occurred to a lesser extent by Day 10 in the animals subjected to UNX. Evidence of significant @entity4434 was present during the acute phase in both groups, as reflected by changes in the fractional excretion of @entity1372 or lysozyme. Persistent @entity4434 was noted on Day 10 in both the sham and UNX groups, but the degree of dysfunction was greater in the UNX animals. The in vitro uptake of organic ions by renal cortical slices was reduced 24 hr following the injection of @entity3143 although no difference was seen between the experimental groups. @entity349 content within renal cortex was not increased in the UNX group at 1 or 3 hr but was higher 24 hr postinjection. Total urinary @entity349 excretion during the first day was not altered by UNX although single-kidney excretion was increased dramatically. These studies suggest that @entity35 are more susceptible to @entity3143 -induced nephrotoxicity 2 days following UNX. Although the mechanism(s) of this @entity130 remains unclear, it does not appear to be completely related to an increase in renal cortical @entity349 content.
