Feasibility of endoscopic resection in XXXX .

@entity1 @entity3578 @entity5 @entity895 @entity1721 @entity3
BACKGROUND: Endoscopic resection in @entity1 with @entity1721 ( @entity1721 ) is limited by the presence of lymph node @entity3 (LNM), highlighting the importance of determining which @entity1 have virtually no risk of LNM. OBJECTIVE: To investigate the clinicopathological parameters predicting LNM in @entity1 who underwent esophagectomy for SESCs and to identify the best candidate @entity1 for endoscopic resection. DESIGN: Retrospective, single-center study. SETTING: Tertiary-care center. @entity1 : A total of 190 @entity1 who underwent esophagectomy for SESCs between 1991 and 2009. INTERVENTIONS: Esophagectomy with lymph node dissection. MAIN OUTCOME MEASUREMENTS: LNM. RESULTS: Of 190 @entity1 , 39 (20.5%) had LNM. The rates of LNM in @entity1 with m1, m2, m3, @entity895 , @entity3578 , and sm3 lesions were 0.0% (0/18), 8.7% (4/46), 25.0% (6/24), 15.0% (3/20), 26.0% (7/27), and 37.3% (19/51), respectively. On multivariate analysis, lymphovascular invasion (LVI) (P<.001), superficial @entity5 size (P=.004), and lower LMM (lamina muscularis mucosae) invasion width (P<.001) were independent predictors of LNM in @entity1 with @entity1721 invading the LMM. Among 63 @entity1 with mucosal or @entity895 @entity5 3 cm or smaller, only 1 had LNM without LVI showing a lower LMM invasion width greater than 3.0 mm. LIMITATIONS: Retrospective analysis. CONCLUSIONS: Endoscopic resection should be performed for mucosal @entity5 of 3 cm or less without positive lymph nodes. Moreover, if pathological examination of the endoscopically resected specimens shows invasion of the @entity895 layer and a lower LMM invasion width of 3.0 mm or less, indicating an absence of LVI, the @entity1 can be carefully observed without additional treatment.
