Effect of Minor Liver Function Test Abnormalities and Values Within the Normal Range on Survival in XXXX .

@entity1 @entity712 @entity648 @entity492 @entity741 @entity493
UNASSIGNED: Liver function test (LFT) abnormalities are often observed in @entity1 with @entity712 ( @entity712 ). However, the relation of LFTs with outcomes has not been well described. @entity1 of the VA Palo Alto Health Care System (3 inpatient facilities and 7 community clinics) with a complete set of LFTs in the 60  days before a first @entity712 diagnosis were included in the analysis from January 2005 to April 2013. A total of 2,096 @entity1 met inclusion criteria. @entity1 were a mean of 71    12  years old, 97% were @entity1 , 57% had a previous diagnosis of @entity741 , and the mean left ventricular ejection fraction was 51    12%. The median (twenty fifth and seventy fifth) values were albumin 3.6 g/dl (3.3, 3.9), @entity493 transaminase 21 IU/L (16, 30), @entity492 transaminase 24 IU/L (20,31), AP 70 IU/L (57, 87), and total @entity648 0.8 mg/dl (0.6, 1.0). There were 851 deaths (41%) over a mean duration of 41    27  months. Mortality significantly increased with lower values of albumin and @entity493 transaminase and higher levels of @entity492 transaminase and AP. The association with total @entity648 was not significant. In conclusion, many LFT values in the "normal" range are independently associated with decreased survival beyond traditional risk factors for mortality in @entity712 .
