Evaluating the Potential Effect of XXXX on the post-Cardiac Surgery Sleep Disorder.

@entity1 @entity73 @entity16 @entity2493 @entity6720 @entity148 @entity1245 @entity933 @entity25
BACKGROUND: Postoperative @entity16 , including @entity73 , @entity25 , @entity933 , and @entity148 , are the important consequences of coronary artery bypass graft surgery (CABG). Evidence has shown that postoperative @entity25 is partly due to disturbed @entity2493 secretion in the perioperative period. The aim of this study was to evaluate the effect of @entity2493 on postoperative @entity25 in @entity1 undergoing CABG. METHOD: One hundred forty-five elective CABG @entity1 participated in a randomized double-blind study during the preoperative period. The @entity1 were randomized to receive either 3 mg of @entity2493 or 10 mg of @entity6720 one hour before sleep time. Each group received the medication from 3 days before surgery until the time of discharge. Sleep quality was evaluated using the Groningen Sleep Quality Score (GSQS), and the incidence of @entity933 was evaluated by nursing records. Sleep quality and @entity148 scores were compared before and after surgery through the Wilcoxon signed-rank test. The analysis of covariance (ANCOVA) and independent t-test were used to compare the sleep and @entity148 scores between the groups. P values  <= 0.05 were considered statistically significant. RESULTS: Totally, 137 @entity1 at a mean age of 60 years completed the study (76% male). The analysis of the data showed that sleep was significantly disturbed after surgery in both groups. The @entity1 in the @entity6720 group demonstrated significantly higher disturbance in their mean postoperative GSQS score than did their counterparts in the @entity2493 group (p value < 0.001). A smaller proportion of the @entity1 experienced @entity933 in the @entity2493 group (0.06%) than in the @entity6720 group (0.12%); however, this difference was not statistically significant. CONCLUSION: The result of the present study revealed that @entity2493 improved sleep in post-cardiac surgery @entity1 more than what was observed with @entity6720 . Therefore, @entity2493 may be considered an effective alternative for @entity1245 in the management of postoperative @entity25 .
