Developmental changes of selected minerals in Zucker XXXX .

@entity28 @entity219 @entity1372 @entity920 @entity972 @entity35 @entity68
Effects of @entity28 and age on @entity920 , @entity68 , @entity219 , @entity1372 , @entity972 , and protein were compared in liver, kidney, brain, and muscle of @entity28 (fa/fa) and nonobese (non-fa/fa) male Zucker @entity35 . Blood plasma cerulopasmin, @entity920 , @entity219 , @entity1372 , and @entity972 were also determined. Mean brain weight of fa/fa @entity35 was less than that of non-fa/fa @entity35 at 12 weeks of age; mean brain protein concentration was greater in fa/fa than in non-fa/fa at 5 and 12 weeks of age. At 18-19 days of age, mean @entity1372 concentration (mg/g protein) in liver of fa/fa was less than that of non-fa/fa. At 5 weeks of age, mean @entity920 concentration (microgram/g protein) in kidney was greater in fa/fa. Mean total @entity920 , @entity68 , @entity219 , @entity1372 , and @entity972 in liver and kidney were greater in fa/fa than in non-fa/fa at 5 weeks because of the larger livers and kidneys of fa/fa. Mean concentrations of @entity920 , @entity219 , @entity1372 , and @entity972 per gram of brain protein were slightly (6-10%) less in fa/fa than in non-fa/fa at 5 weeks. By 12 weeks, mean concentrations of @entity920 in liver, kidney, (tibialis) muscle, and blood plasma, ceruloplasmin in blood plasma, @entity219 in liver and muscle, @entity68 in muscle, and @entity1372 in liver were greater in fa/fa than in non-fa/fa. However, total amount of each mineral in muscle at 12 weeks was less in fa/fa than in non-fa/fa because of the smaller mean muscle weight of fa/fa. Mean concentrations of @entity920 and @entity219 in brain and of @entity68 in liver and brain were less in fa/fa than in non-fa/fa at 12 weeks. The major age-related changes in fa/fa that were not observed in non-fa/fa were large increases in liver and kidney @entity920 between 5 and 12 weeks of age. It seems that the abnormal mineral metabolism is a consequence of the @entity28 , but the mechanisms are not identified.
