An Integrated Risk Reduction Intervention can reduce body mass index in individuals being treated for XXXX : results from a randomized trial.

@entity1 @entity162 @entity28 @entity146 @entity1017 @entity165 @entity1851
OBJECTIVES: We conducted a randomized, controlled trial comparing the efficacy of an Integrated Risk Reduction Intervention (IRRI) to a control condition with the objective of improving mood stability and psychosocial functioning by reducing cardiometabolic risk factors in overweight/ @entity28 @entity1 with @entity162 . METHODS: A total of 122 @entity1 were recruited from our outpatient services and randomly allocated to IRRI (n  =  61) or @entity146 care with medical monitoring (n  =  61). Individuals allocated to IRRI received @entity146 treatment and assessment, medical monitoring by a nurse, and a healthy lifestyle program from a lifestyle coach. Those allocated to the control condition received @entity146 treatment and assessment and referral, if indicated, for medical problems. A mixed-effects model was used to examine the impact of the interventions on body mass index (BMI). Exploratory moderator analyses were used to characterize those individuals likely to benefit from each treatment approach. RESULTS: Analyses were conducted on data for the IRRI (n  =  58) and control (n  =  56) @entity1 with >= 1 study visit. IRRI was associated with a significantly greater rate of decrease in BMI (d  =  -0.51, 95% confidence interval: -0.91 to -0.14). Three variables ( @entity1851 , total @entity165 , and instability of total sleep time) contributed to a combined moderator of faster decrease in BMI with IRRI treatment. CONCLUSIONS: Overweight/ @entity28 @entity1 with @entity162 can make modest improvements in BMI, even when taking medications with known potential for @entity1017 . Our finding that a combination of three baseline variables provides a profile of @entity1 likely to benefit from IRRI will need to be tested further to evaluate its utility in clinical practice.
