Characterisation of the progression of @entity11725 -induced @entity35 XXXX by proliferative cell nuclear antigen, basement membrane laminin and trypsinogen immunohistochemistry.

@entity788 @entity1975 @entity35 @entity652 @entity420 @entity11725
The progression of @entity11725 -induced @entity35 @entity788 ( @entity420 ) was characterised using quantitative and semiquantitative immunohistochemistry for @entity1975 ( @entity1975 ), basement membrane laminin (BML) and trypsinogen (TG). Samples were taken 5-20 months after initiation. High @entity1975 -labelling indices ( @entity1975 LIs) were measured 5 months after the induction of atypical acinar cell nodules (AACNs), which decreased later and stagnated until a further decline in the month 10 @entity652 . Then a second premalignant proliferative wave was observed (month 13) within the @entity652 stage. Later, in month 20 differentiated ACs @entity1975 LIs fell to the host tissue level but were found highest in the month 20 anaplastic ACs indicating a switch to malignant proliferation. Month 20 invasive ACs showed a number of separate proliferative foci. In early AACNs, BML decreased and remained low till the local maximum in the month 13 @entity652 . Invasive ACs did not express BML. Month 5 AACN and differentiated @entity420 were TG deficient but anaplastic @entity420 regained its TG expression. However invasive @entity420 was again TG negative. These results are discussed in combination with our previous data on progressional changes of autophagic capacity and microvessel densities.
