Establishment and ultrasound characteristics of XXXX in @entity2608 .

@entity1 @entity697 @entity1317 @entity730 @entity2608 @entity731 @entity121
BACKGROUND: @entity731 is one of the main risk factors cause @entity697 . It's of great significance to establish an @entity731 animal model that can mimic the characteristics and nature course of @entity1 @entity1 . Therefore, a @entity2608 model was induced by high-fat diet to monitor their lipid profile and @entity121 ( @entity121 ) of artery walls and study @entity731 progression. METHODS: Fifty male @entity2608 were enrolled in this study. All of these monkeys were aged 7 to 14 years with BMI >30 kg/m2. They were fed with high-fat diet containing 10% of fat for the first 48 weeks. Use ultrasound to measure the @entity121 at bilateral common carotid arteries and their bifurcations and aorta (AO) of the monkeys, and screen out the individuals with thickened @entity121 for the next phase. In the next 48 weeks, some of these monkeys (n = 4) were fed with standard diet containing 3% fat. Meanwhile the other monkeys (n = 5) were fed with high-fat diet for another 48 weeks. Their serum lipid level was monitored and arterial @entity121 was also determined periodically. RESULTS: Serum lipid level of all 50 monkeys elevated after fed with high-fat diet for the first 48 weeks. @entity121 thickening at right common carotid bifurcation and aorta (AO) was thickened in 9 monkeys. Furthermore, 4 of these 9 monkeys were fed with standard diet and other 5 monkeys were fed with high-fat diet in the following 48 weeks. The serum lipid level of the 4 monkeys recovered and their @entity121 at RBIF and AO did not progress. However, the lipid level of other 5 monkeys remained high, and their @entity121 thickening of AO progressed, and plaques and @entity730 focuses were found at the anterior wall of aorta near the bifurcation of common iliac artery. CONCLUSIONS: After high-fat diet induction for 96 weeks, serum lipid levels of @entity2608 elevated significantly, which subsequently caused @entity121 thickening and plaques formation. When @entity121 thickening occurred, further @entity1317 may be prevented by reducing diet fat content. Our study indicates that @entity1317 of high-fat diet induced @entity2608 is similar to that of @entity1 in position and progression.
