[Post-sectional antral peptic ulcer and antrofundic re- @entity254 in XXXX (manifestation of a probable antrofundic neuroendocrine center)].

@entity308 @entity9113 @entity1373 @entity254 @entity4494 @entity2918 @entity3157 @entity51 @entity35
The antrum-fundic section and re- @entity254 (AESR), liberates, in @entity35 male @entity35 , genuine antral peptic ulcers. They start within 20 days. They are progressive evolution, penetrating into all gastric walls. Between 7 and 8 months, they involve near organs (spleen, liver, pancreas) and produce a great inflammatory reaction of the @entity4494 . The antral peptic ulcer is induced if the gastric lesser curvature's nerves are sectioned and a concomitant pyloroplasty is done or not. The gastric hemisection, if anterior or posterior, break out the peptic ulcer only on the same side of the antrum-fundic interruption. In all this situations, except in cases of concomitant pyloroplasty, it is proved a pronounced and significantly increase of the gastric (g/kg), but not pancreatic index. In the AFSR series with nervous section on the lesser curvature and without pyloroplasty, the percentage of antral peptic ulcers in 56%. It is postulated the probably existence, at an antrum-fundic level, of a neuroendocrine center. Its nullification or disturbance by the section and re- @entity254 procedure could generate the antral ulcer and other histologic changes (increase of the "G" cells, @entity1373 of the parietal, ECL and "A like" cells) by one or various hypothetical ways: 1. Direct action, nullifying the normal blocking function of somatostative over the "G" cells and or parietal cells. 2. Disturbing or nullifying the motor pump effect of the gastric antrum, and on this way, enhancing the duodenum-gastric reflux with all know deleterious effects of the bile in the antrum particularly in an acid milieu. 3. Modifying, in the opposite direction, the sensitivity by one hand, of the "G" cells mass and by the other one, of the parietal, ECL and "A like" cells. The @entity308 of the fundic sensitivity will induce the @entity1373 of the "G" cells, the hypersecretion of @entity9113 and, "a posteriori", all the secretory effects and trophic characteristic of it. 4. Disturbing the @entity2918 secretion, perhaps through a @entity51 , with the resulting epiphenomenon of a cytoprotection deficit mediated through the mucus and @entity3157 production. It is probably that the proposed physiopathogenic mechanism are associated and that the final result, the antral peptic ulcer is the consequence of an increase of the aggressive factors (acid, bile) and a concomitant @entity308 of the defensive factors (cytoprotection), starting normally by the @entity2918 through the mucus and @entity3157 secretion.
