Ultrastructural alterations in @entity4974 - induced XXXX : early lesions.

@entity296 @entity39 @entity4 @entity4974 @entity35 @entity715 @entity528
Ultrastructural studies were made of the early changes induced in left ventricular myocardium by @entity4974 given to @entity35 either in drinking water (10.7 mM for 1 to 7 days) or by gavage (100 mg. per kg. per day for 1 or 2 days). @entity35 on the drinking water protocol developed myocardial alterations evident by light and electron microscopy within 2 days; those given @entity4974 by gavage developed lesions after 24 hours. The earliest alteration consisted on @entity4 and "activation" of interstitial cells possessing an oblong shape, abundant rough endoplasmic reticulum, occasional lysosomes, a prominent Golgi apparatus, few mitochondria, and large irregular nuclei (often with a typical "Anitschkow" morphology). Mitoses of these interstitial cells were frequent. Mitoses were also observed in endothelial cells. Acute @entity296 , which developed after 6 days of the drinking water protocol or one gavage dose, was characterized by focal @entity528 with lipid droplet accumulation and Z-line distortion and dissolution, especially prominent in areas of intercellular junctions. These focal lesions coalesced to involve whole myocytes with severe @entity528 and contraction band @entity39 . Mitochondria of severely altered cells were swollen and contained dense inclusions. Nuclei had prominent nucleoli and, in severely @entity39 cells, clumped and irregular chromatin. Large areas of @entity39 myocardium showed extravasated red blood cells and minimal intra- and extracellular deposition of fibrin. Vascular @entity39 or @entity715 was not seen. A prompt inflammatory infiltrate was composed predominantly of macrophages invading @entity39 myocytes, with occasional polymorphonuclear neutrophilic and eosinophilic leukocytes.
