Gene interactions and structural brain change in early-onset XXXX subjects using the pipeline environment.

@entity73 @entity71571 @entity71572 @entity195 @entity71573 @entity71575 @entity71574
OBJECTIVE: This article investigates subjects aged 55 to 65 from the @entity195 Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) @entity73 using neuroimaging and genetics biomarkers. METHODS: Nine of the subjects had EO-AD ( @entity195 ) and 27 had EO-MCI (mild @entity73 ). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers. RESULTS: We identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between @entity71571 and L_hippocampus (volume), and between @entity71571 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between @entity71572 and R_superior_frontal_gyrus (volume), and between @entity71573 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between @entity71574 and L_rectus gyrus (surface area), and between @entity71575 and L_rectus_gyrus (surface area). CONCLUSION: We observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.
