Assessment of fetal risk associated with exposure to XXXX chemotherapy during pregnancy: a multicenter study.

@entity5 @entity1 @entity5617 @entity600
The objective of the present study was to evaluate and quantify fetal risks involved in the administration of @entity5 chemotherapy during gestation, as well as to assess the long-term effects on the exposed @entity1 . In this retrospective, cohort study, we reviewed the records of @entity1 aged 15 to 45 years with a diagnosis of @entity5 with malignant behavior at three reference services in the State of Rio Grande do Sul, Brazil, from 1990 to 1997. All @entity1 with a diagnosis of pregnancy at any time during the course of the disease were selected, regardless of whether or not they received specific medication. Fetal outcomes of 14 pregnancies with chemotherapy exposure were compared to that of 15 control pregnancies in which these drugs were not used. Long-term follow-up of the exposed @entity1 was carried out. Fisher's exact test was used to compare the groups. Continuous variables were compared by the Wilcoxon-Mann-Whitney test. We found an increased rate of prematurity (6/8 vs 2/10; RR: 3.75; CI: 1.02-13.8; P = 0.03) in the exposed group. There was a trend to an @entity5617 rate (4/12 vs 0/10; P = 0.07) in the group exposed to chemotherapy. No @entity600 were detected in any @entity1 , which can be related to our small sample size as well as to the fact that most exposures occurred after the first trimester of pregnancy. Other larger, controlled studies are needed to establish the actual risk related to @entity5 chemotherapy during pregnancy.
