Combined use of endothelial function assessed by brachial ultrasound and high-sensitive XXXX in predicting @entity65 .

@entity1 @entity712 @entity583 @entity450 @entity453 @entity731 @entity385 @entity65 @entity1851
BACKGROUND: Endothelial function plays a key role in determining the clinical manifestations of @entity731 . Elevated high-sensitive @entity1851 (hsCRP) relates to long-term prognosis of @entity65 . HYPOTHESIS: We test the hypothesis that combined use of endothelial function and hsCRP could increase predictive value of future @entity65 . METHODS AND RESULTS: 205 @entity1 were followed up for a median period of 24 months. Endothelial function was assessed using brachial ultrasound to measure endothelium-dependent @entity450 ( @entity450 ). Cox regression analyses were conducted for the 205 subjects, with @entity65 being defined as @entity583 , hospitalization due to @entity712 , percutaneous coronary intervention, coronary artery bypass grafting, and @entity385 . Twenty nine (14%) developed @entity65 . Both @entity450 and hsCRP were significantly predictive of @entity65 (relative risk for @entity1 with @entity450 <3% as compared to those with @entity450 >6%, 4.65, 95% confidence interval (CI): 1.30-16.66, p=0.018; relative risk for the highest as compared with the lowest tertile of hsCRP level, 3.59, 95% CI: 1.32-9.74, p=0.012, respectively). Further risk analysis was performed among four groups classified by @entity450 ( @entity450 >or= 6% or<6%) and half percentile of hsCRP (hsCRP >or= 1 or<1 mg/dL). Relative risks for the @entity450 <6%/hsCRP >or= 1 mg/dL group compared to @entity450 >or= 6%/hsCRP<1 mg/dL group increased markedly to 12.598 (95% CI: 1.69 to 94.14, p=0.014) for @entity65 . CONCLUSIONS: @entity1 with suspected @entity453 may benefit from risk stratification based on both endothelium-dependent @entity450 and hsCRP, since combined these two factors contribute significantly toward the incidence of @entity65 .
