Association between XXXX Promoter Methylation and @entity213 : A Meta-Analysis of 21 Published Studies.

@entity5 @entity213 @entity986
BACKGROUND: The @entity986 is an important @entity5 suppressor gene (TSG) and aberrant methylation of promoter is known to be a major inactivation mechanism of the @entity5 suppressor and @entity5 -related genes. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of @entity213 ( @entity213 ). However, some studies have reported differences in the methylation frequencies of @entity986 promoter between @entity5 and the corresponding control group. Therefore, we conducted a meta-analysis to better identify the association. METHODS: PubMed, Ovid, ISI Web of Science, and EMBASE were searched to identify eligible studies to evaluate the association of @entity986 promoter methylation and @entity213 . Odds ratio (ORs) and 95% confidence intervals (95%CI) were calculated to evaluate the strength of association between @entity986 promoter methylation and @entity213 . RESULTS: A total of twenty-one studies with 1155 cases and 1017 controls were included in the meta-analysis. The frequencies of @entity986 promoter methylation in the @entity5 group were significantly higher than those in the control group ( @entity5 group: median: 46.67%, range = 7.84%-95.12%; control group: median: 18.37%, range = 0-83.33%; respectively). The pooled odds ratio was 3.37 (95%CI = 2.32-4.90) in the @entity5 group versus the corresponding control group under the random-effects model. CONCLUSION: This meta-analysis of 21 published studies identified that aberrant methylation of @entity986 promoter was found to be significantly associated with @entity213 .
