XXXX downregulates @entity125 signaling via modulating @entity18076 and suppresses oncogenic properties of PANC-1 @entity5 stem-like cells.

@entity1 @entity788 @entity23332 @entity4729 @entity5 @entity2423 @entity10430 @entity16719 @entity1759 @entity8889 @entity125 @entity18076 @entity136
UNASSIGNED: @entity788 represents one of the most aggressive types of @entity5 due to its high resistance towards most clinically available treatments. The presence of @entity788 stem-like cells (CSCs) have been attributed to the intrinsically high resistance and highly metastatic potential of this disease. Here, we identified and isolated @entity788 stem-like cells using side-population (SP) method from @entity1 @entity788 cell line, PANC-1. We then compared the SP and non-SP PANC-1 cells genetically. PANC-1 SP cells exhibited @entity5 stem-like cell properties including enhanced self-renewal ability, increased metastatic potential and resistance towards @entity136 treatment. These @entity5 stem-like phenotypes were supported by their enhanced expression of @entity10430 , @entity4729 and @entity1759 . A traditional plant-derived anti-oxidant, @entity23332 , have been implicated for its anti- @entity5 properties. Here, we found that @entity23332 treatment to PANC-1 SP cells significantly suppressed the stem-like properties of PANC-1 SP cells and metastatic potential by down-regulating the expression of @entity2423 , @entity16719 , @entity10430 , @entity8889 and @entity125 . More importantly, @entity23332 treatment led to the up-regulation of several @entity5 suppressor miRNAs and @entity18076 increased by @entity23332 treatment was found to target and down-regulate @entity125 . Thus, PANC-1 SP cells may serve as a model for studying drug-resistant @entity788 stem-like cells and @entity23332 has the potential as an antagonist against pancreatic CSCs. This article is protected by copyright. All rights reserved.
