Long-term cardiovascular outcomes in type 1 XXXX @entity1 after simultaneous pancreas and kidney transplantation compared with living donor kidney transplantation.

@entity1 @entity6 @entity453 @entity65 @entity454
AIMS/HYPOTHESIS: Mortality due to @entity65 ( @entity65 ), particularly @entity453 ( @entity453 ), is high in type 1 @entity6 @entity1 with @entity454 ( @entity454 ). We aimed to determine whether normoglycaemia, as achieved by successful simultaneous pancreas and kidney (SPK) transplantation, could improve long-term outcomes compared with living donor kidney-alone (LDK) transplantation. METHODS: We studied 486 type 1 @entity6 @entity1 with @entity454 who underwent a first SPK (n   =   256) or LDK (n   =   230) transplant between 1983 and 2012 and were followed to the end of 2014. Data were retrieved from the Norwegian Renal Registry and hospital records. Kaplan-Meier plots and multivariate Cox regression, with correction for recipient, donor and transplant factors, were used to examine potential associations between transplant type and all-cause and @entity65 - and @entity453 -related mortality. RESULTS: Median follow-up time was 7.9  years (interquartile range 4.3, 12.9). The adjusted HR for @entity65 -related deaths in SPK recipients compared with LDK recipients was 0.63 (95% CI 0.40, 0.99; p   =   0.047), while the HRs for all-cause and @entity453 -related mortality were 0.81 (95% CI 0.57, 1.16; p   =   0.25) and 0.63 (95% CI 0.36, 1.12; p   =   0.12), respectively. Compared with the LDK group, SPK recipients were younger and received grafts from younger donors. @entity65 was higher in @entity1 transplanted between 1983 and 1999 compared with those who received their grafts in subsequent years. CONCLUSIONS/INTERPRETATION: In @entity1 with type 1 @entity6 and @entity454 , SPK transplantation was associated with reduced long-term cardiovascular mortality compared with LDK transplantation.
