Dietary intake of cottonseed toxins is hypothesized to be a partial cause of XXXX .

@entity1 @entity548 @entity6319 @entity3072 @entity195 @entity35 @entity165
The cause of @entity195 is not known. The most influential known risk factor is increasing age. The risk factor of increasing age is consistent with exposure to environmental toxins throughout life as a cause of Alzheimer's. In addition, microbleeding, changes in membrane permeability and increased @entity165 are all factors important in Alzheimer's. Cottonseed contains toxins and is fed to animals, fish and poultry. Cottonseed toxins remain in the animals, fish and poultry and are present in the @entity1 diet at seemingly low levels. The average @entity1 is ingesting cottonseed toxins throughout life. Cottonseed toxins cause @entity548 , changes in membrane permeability and increased @entity165 . In addition, the cottonseed toxin @entity6319 is known to reach the brain and bind randomly to important cellular structures. @entity6319 also binds to microtubules and interferes with microtubule assembly, which may inhibit binding of tau to microtubules and lead to formation of @entity3072 . Cottonseed toxins are also known to accumulate in the body. In a preliminary study of female @entity35 fed low level cottonseed for their lifetimes, apparent @entity3072 and phosphorylated tau were found. The intake of cottonseed toxins throughout life should be evaluated further as a possible cause of Alzheimer's.
