Molecular Insights into the Possible Role of @entity44922 and XXXX in Thyroid Hormone Biosynthesis.

@entity19 @entity44922 @entity58477 @entity58478
UNASSIGNED: Introduction: Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role in hormone release, cell excitability, pH and K(+) homeostasis in many tissues. Objectives: To investigate the thyroid developmental expression of three members, @entity44922 , @entity58477 and @entity58478 , in @entity19 . To postulate the K(+) channel role in thyroid hormone secretion. Material and Methods: Quantitative RT-PCR analysis of @entity44922 , @entity58477 and @entity58478 in @entity19 of different stages (E13.5-E18.5). Results: mRNA for @entity44922 , @entity58477 and @entity58478 were identified and increased with age in @entity19 . Both @entity44922 and @entity58477 genes are better expressed after E16.5. @entity58477 greatly increases from E13.5 to E16.5 (p  <= 0.05). Conclusion: Quantitative PCR shows that the @entity19 thyroid presents increased expression for Kir channels during development. The role of Kir in thyroid morphogenesis and differentiation might be understood in future studies. We speculate that thyroglobulin trafficking might be modulated by @entity44922 /5.1.    2014 S. Karger AG, Basel.
