[Clinical, endoscopic and morphological manifestations of oesophageal lesion in XXXX ].

@entity1 @entity355 @entity2681 @entity2910 @entity1066 @entity117 @entity354 @entity10632 @entity309 @entity785
Oesophageal lesion is the commonest visceral manifestation of @entity785 ( @entity785 ) affecting the quality of life and fraught with serious complications. The aim of this study was to evaluate clinical, endoscopic andmorphological manifestations of oesophageal lesion in @entity785 and its relationships with other clinical symptoms and pharmacotherapy of the disease. MATERIALS AND METHODS: 479 @entity1 with @entity785 (93.7% @entity1 , 6.3% @entity1 , mean age 48.7 +/- 19.2 yr). All of them underwent EGDS in 2005-2010. 123 @entity1 were examined for the detection of @entity355 ( @entity355 ), total screening regardless of complaints was conducted in 2010. Control group included 1018 age and sex-matched @entity1 with @entity309 who underwent EGDS in 2008-2009. RESULTS: Oesophageal lesions occurred much more frequently in @entity785 than in @entity309 . Oesophageal symptoms were documented in 70.0 and 29.9% cases, @entity2681 in 28.8 and 1.5%, @entity2910 in 22.5 and 2.2% @entity1066 in 0.8 and 0% (p < 0.001). @entity355 manifested as intestinal metaplasia (histological study of mucosal biopsy) was found in 30 @entity785 @entity1 (4.2%). Screening revealed @entity355 in 8.9% of the @entity1 . The development of @entity2681 was unrelated to the age of the @entity1 , duration of the disease and its form (localized or diffusive), lung pathology or @entity10632 . Cytotoxic medicines significantly increased the frequency of @entity2681 , it tended to increase under effect of NSAID and low doses of @entity117 . Long-term intake of PPI did not reduce the risk of @entity354 and @entity355 . CONCLUSION: Half of the @entity1 with @entity785 have @entity354 . Over 20% of them suffer its complications ( @entity2681 and @entity1066 ) and 9% have @entity355 . All such @entity1 need endoscopic study ofoesophagus regardless of clinical symptoms.
