PET-based quantification of statistical properties of @entity5 subvolumes in XXXX .

@entity5 @entity135 @entity519 @entity1
PURPOSE: PET @entity519 imaging of @entity135 ( @entity135 ) has the potential to stratify the response to radiochemotherapy. The aim of this work was to quantify the statistical properties of @entity5 subvolumes measured by PET, and their impact on failure rate of standard chemoradiation. METHODS: A PubMed search was undertaken to identify relevant publications between 2001 and July 2015, containing original data regarding the properties of @entity135 @entity519 subvolumes and their evolution during therapy, measured using specific PET tracers. RESULTS: The number and intensity of @entity519 voxels is significantly reduced during therapy. @entity1 are 4.2 times more likely to have negative outcome if baseline @entity519 . The change of the @entity519 volume during therapy, as well as the statistical distribution of the @entity519 fraction (HF), is quantified and analyzed. HF strongly correlates with the median T/M ( @entity5 -to-muscle) SUV (standard uptake value) ratio, but not with gross @entity5 volume. @entity519 is 2.2 times more frequently manifest in T3   +   T4 than in T1   +   T2 @entity5 . Calculated quantities are presented for primary and @entity5 separately, where available. CONCLUSIONS: Although @entity519 diminishes during chemoradiation, it is a major predictor of outcome. HF, if large enough, can be predicted from the median T/M SUV ratio. CT-delineated gross @entity5 size does not influence the percentage of @entity519 voxels. @entity5 are less likely @entity519 at an earlier stage.
