Brain/gut peptides in fed and fasted XXXX .

@entity1042 @entity6140 @entity11384 @entity8586 @entity2339 @entity35 @entity12180 @entity393
The concentrations and contents of vasoactive intestinal peptide ( @entity12180 ) and @entity8586 ( @entity6140 ) in the brain and of these peptides along with secretin and glucagon-like immunoreactivity (GLI) in the gut were compared in a group of 16 5-day fasted adult @entity35 with the corresponding peptides in a group of 16 nonfasted littermates. The mean weight of the fasted @entity35 at the beginning of the study was 263 +/- 10 g (+/- SEM) and was 177 +/- 7 g before killing, for a net loss of 33% of initial body weight; the 16 fed @entity35 increased their mean weight from 225 +/- 11 to 284 +/- 12 g, for a net gain of 12%. During the 5-day fast there was no change in the weight of the cortex, @entity2339 , or brain stem. However, the weight of tissues from the gut decreased to about half the weight of the corresponding tissues in the fed animals. There was no significant change in brain @entity12180 or @entity6140 . @entity12180 content in the gut was unchanged. However, because of the decrease in organ weight, its concentration almost doubled. @entity11384 concentrations in the gut of fasted @entity35 did not change significantly, but organ contents fell to about half. The gut content of GLI also fell by half or more. The concentrations of @entity6140 in @entity1042 extracts of the duodenum and jejunum remained relatively constant, but those in acid extracts fell by 40% in the fasted animals. This represents an approximately 70% decrease in organ content of @entity6140 . These findings are interpretable as demonstrating that during a prolonged fast neuronal @entity6140 and @entity12180 are well conserved, but endocrine @entity6140 , secretin, and GLI are markedly decreased because of @entity393 .
