Effect of sternal closure with biological bone adhesive on XXXX visual analogue score and serum cytokine.

@entity1 @entity650 @entity158
OBJECTIVES: Recently a biocompatible bone adhesive was introduced in addition to the sternal wires to expedite sternal union and improve @entity1 recovery. In this study we aim to objectively assess the biomarker of @entity158 in @entity1 who received the biocompatible bone adhesive. METHODS: A total of 62 @entity1 who underwent sternotomy were prospectively randomised to receive either conventional wire closure (CWC); 32 @entity1 or adhesive enhanced closure in addition to sternal wire (AEC); 30 @entity1 . @entity1 were monitored postoperatively at certain time intervals for incisional @entity158 , serum @entity650 ( @entity650 ) level, analgesia used and postoperative complications. All @entity1 were followed up for 4 weeks. RESULTS: The post-operative @entity158 scores with coughing were significantly higher in the CWC group at 24 hours and 48 hours. The postoperative @entity650 levels were significantly higher in the CWC group in comparison with the AEC group at 6 hours, 24 hours, and 48 hours. There were no significant differences in term of additional analgesia used. No adverse events from adhesive bone cement were observed during follow up. CONCLUSIONS: Adhesive-enhanced sternal closure resulted in modest @entity158 confirmed by @entity158 biomarker. Justification of its routine use requires larger multicentre study.
