Results of HMG (Humegon)-HCG therapy in 6096 treatment cycles of 2166 Japanese XXXX with @entity249 .

@entity1 @entity43 @entity249 @entity5852 @entity548 @entity600 @entity1871
The effects of HMG (Humegon)-HCG therapy in 6096 cycles in 2166 Japanese @entity1 with @entity249 were examined. The rates of ovulation, pregnancy, the @entity43 , @entity5852 , and @entity600 in the newborn were recorded, and the possible factors of multiple pregnancies were analyzed. Ovulation occurred in 73.2% of the cases and 64.5% of the treatment cycles. Pregnancy occurred in 23.0% of the cases and 8.6% of the cycles. @entity43 with grade I of WHO definition or more was observed in 10.3% of the cases and 5.3% of the cycles. The incidence of the @entity43 was high in amenorrheic @entity1 , who respond to @entity1871 with @entity548 . The multiple pregnancy rate was 20.5%, of which 13.0% was twins and 7.5% triplets or more. The abortion rate was 22.0%, and the abortion rate in multiple pregnancy was significantly higher (P less than 0.05) than that in singleton pregnancy. The external @entity600 rate was 1.68% in the 594 newborn who could be examined. No significant differences were found in maternal factors, the treatment schedule, or the ovarian response to treatment in singleton and multiple pregnancy groups. This survey revealed that the efficacy and the incidence of adverse effects of Humegon-HCG therapy in a large number of Japanese @entity1 were not different from those in Caucasians except for a lower rate of multiple pregnancy, and no special causative factors for multiple pregnancy were found.
