Effect of castration on @entity3009 -mediated changes in membrane potential and XXXX synthesis in @entity840 seminal vesicle tissue.

@entity2544 @entity840 @entity2918 @entity1426 @entity3009 @entity3352 @entity3800
@entity1426 stimulated an increase in transmural electrical potential difference (p.d.) in @entity840 seminal vesicle tissue in vitro. Pretreatment with @entity3352 abolished this response. @entity3352 pretreatment did not prevent the p.d. from increasing in response to theophylline. Changes in p.d. in response to @entity1426 were greatly attenuated, and the response to @entity2544 was abolished in seminal vesicle tissue taken from castrated @entity840 . Seminal vesicles, aorta and ileum taken from castrated @entity840 synthesized and released more @entity2918 than did those from control animals. It is concluded that the effects of @entity1426 on p.d. are mediated by its metabolism to @entity2918 ; the inability of seminal vesicles from castrated animals to respond to @entity1426 is not a result of a decrease in @entity3009 production, but is more likely a result of other degenerative changes attendant upon castration; and @entity3800 appear to have some regulatory function on @entity3009 synthesis in a variety of tissues.
