Altered resting state cortico-striatal connectivity in mild to moderate stage XXXX .

@entity1 @entity3034 @entity935 @entity191 @entity179
@entity191 ( @entity191 ) is a progressive @entity179 that is characterized by @entity935 depletion in the striatum. One consistent pathophysiological hallmark of @entity191 is an increase in spontaneous oscillatory activity in the basal ganglia thalamocortical networks. We evaluated these effects using resting state functional connectivity MRI in mild to moderate stage @entity191 @entity1 on and off @entity3034 and age-matched controls using six different striatal seed regions. We observed an overall increase in the strength of cortico-striatal functional connectivity in @entity191 @entity1 off @entity3034 compared to controls. This enhanced connectivity was down-regulated by @entity3034 as shown by an overall decrease in connectivity strength, particularly within motor cortical regions. We also performed a frequency content analysis of the BOLD signal time course extracted from the six striatal seed regions. @entity191 off @entity3034 exhibited increased power in the frequency band 0.02-0.05   Hz compared to controls and to @entity191 on @entity3034 . The @entity3034 associated decrease in the power of this frequency range modulated the @entity3034 associated decrease in connectivity strength between striatal seeds and the thalamus. In addition, the @entity3034 associated decrease in power in this frequency band correlated with the @entity3034 associated improvement in cognitive performance. Our results demonstrate that @entity191 and @entity3034 modulate striatal resting state BOLD signal oscillations and cortico-striatal network coherence.
