Korean Red XXXX Extract Enhances the Anticancer Effects of @entity2213 Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells.

@entity1 @entity137 @entity1892 @entity9052 @entity2213 @entity1860
UNASSIGNED: Although @entity2213 (IM) in the treatment of @entity1860 ( @entity1860 ) remains the best example of successful targeted therapy, majority of @entity1 with @entity1860 suffer its @entity137 profile and develop chemoresistance to existing therapeutic agents. Thus, there is a need to develop novel alternative therapies for the treatment of @entity1860 . Here, we investigated whether Korean red @entity9052 extract (KRGE) could suppress the proliferation and induce chemosensitization in @entity1 @entity1860 cells. Also, we used a human phospho-antibody array containing 46 antibodies against signaling molecules to examine a subset of phosphorylation events after treatment. Korean red @entity9052 extract broadly suppressed the proliferation of five different cell lines, but KRGE was found to be the most potent inducer of apoptosis against KBM-5 cells. It also abrogated the expression of Bcl-2 ( @entity1892 2), Bcl-xL ( @entity1892 -extra large), survivin, inhibitors of apoptosis protein 1/2, COX-2 (Cyclooxygenase-2), cyclin D1, matrix metalloproteinase-9, and VEGF (Vascular endothelial growth factor), as well as upregulated the expression of pro-apoptotic gene products. Interestingly, KRGE also enhanced the cytotoxic and apoptotic effect of IM in KBM-5 cells. The combination treatment of KRGE and IM caused pronounced suppression of p38 and signal transducer and activator of transcription 5 phosphorylation and induced phosphorylation of p53 compared with the individual treatment. Our results demonstrate that KRGE can enhance the anticancer activity of IM and may have a substantial potential in the treatment of @entity1860 . Copyright    2015 John Wiley _ Sons, Ltd.
