Lens aging in relation to nutritional determinants and possible risk factors for age-related XXXX .

@entity1 @entity231 @entity620 @entity7695 @entity1881 @entity165 @entity2118 @entity8665
OBJECTIVE: To investigate whether nutritional factors and possible risk factors for @entity231 influence the lens optical density (LOD). DESIGN: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for @entity8665 , @entity7695 , @entity620 , @entity1881 , and @entity165 levels. Adipose tissue (n = 187) was analyzed for @entity8665 level. The LOD and the @entity2118 ( @entity2118 ) were measured by spectral fundus reflectance. RESULTS: The mean +/- SD LOD at 420 nm was 0.52 +/- 0.17. It showed a significant association with age (beta =.008, P<001) and @entity2118 (beta = -.096, P =.02). For subjects 50 years and younger (mean +/- SD LOD, 0.45 +/- 0.11), we found only a single significant beta coefficient, for age (beta =.006, P<.001). For subjects older than 50 years (mean +/- SD LOD, 0.68 +/- 0.16), we found significant beta coefficients for age (beta =.011, P<.001) and @entity2118 (beta = -.240, P =.005). Controlling for age, we found no associations between LOD and other possible risk factors for age-related @entity231 or serum or adipose tissue concentrations of carotenoids, @entity620 , and @entity1881 . CONCLUSIONS: Macular pigment is composed of @entity8665 and @entity7695 , the only carotenoids found in @entity1 lenses. The inverse relationship between LOD and @entity2118 suggests that @entity8665 and @entity7695 may retard aging of the lens.
