Autoregulation monitoring and outcome prediction in neurocritical care XXXX : Does one index fit all?

@entity1 @entity1545 @entity131 @entity712 @entity2653 @entity6 @entity10166 @entity13147
UNASSIGNED: Indexes @entity10166 and Mx have been formerly introduced to assess cerebral autoregulation and have been shown to be associated with 3-month clinical outcome. In a mixed cohort of neurocritical care @entity1 , we retrospectively investigated the impact of selected clinical characteristics on this association. Forty-one @entity1 (18-77  years) with severe traumatic ( @entity131 , N  =  20) and non-traumatic (N  =  21) @entity1545 were studied. Cerebral blood flow velocity, arterial blood pressure and intracranial pressure were repeatedly recorded during 1-h periods. Calculated @entity10166 and Mx were correlated with 3-month clinical outcome score of @entity2653 ( @entity2653 ) in different subgroups with specific clinical characteristics. Both @entity10166 and Mx correlated significantly with outcome ( @entity10166 : r  =  0.38, p  <  0.05; AUC  =  0.64, n.s./Mx: r  =  0.48, p  <  0.005; AUC  =  0.80, p  <  0.005) in the overall group, and in @entity1 with hemicraniectomy (N  =  17; @entity10166 : r  =  0.73, p  <  0.001; AUC  =  0.89, p  <  0.01/Mx: r  =  0.69, p  <  0.005; AUC  =  0.87, p  <  0.05). Mx, not @entity10166 , correlated significantly with @entity2653 in @entity1 with @entity712 (N  =  17; r  =  0.69, p  <  0.005; AUC  =  0.92, p  <  0.005), and in non-traumatic @entity1 (r  =  0.49, p  <  0.05; AUC  =  0.79, p  <  0.05). @entity10166 , not Mx, correlated significantly with @entity2653 in @entity131 @entity1 (r  =  0.63, p  <  0.01; AUC  =  0.89, p  <  0.01). Both indexes did not correlate with @entity2653 in @entity6 @entity1 (N  =  15), @entity10166 failed in hypocapnic @entity1 (N  =  26). Both @entity10166 and Mx were significantly associated with 3-month clinical outcome, even in @entity1 with hemicraniectomy. @entity10166 was more appropriate for @entity131 @entity1 , while Mx was better suited for non-traumatic @entity1 and @entity1 with @entity712 . Prognostic values of indexes were affected by @entity6 (both Mx and @entity10166 ) and @entity13147 ( @entity10166 only).
