Bilateral caudal zona incerta nucleus stimulation for essential XXXX : outcome and quality of life.

@entity1 @entity400 @entity4653
BACKGROUND: Over the past few years, bilateral stimulation of the caudal or motor part of the zona incerta nucleus (cZI) has been performed by the authors in @entity1 with essential @entity400 (ET). Outcomes including quality of life data in 15 @entity1 with a follow-up period of up to 84 months (mean 31.7    28.6 months) are presented. METHODS: 15 consecutive ET @entity1 underwent MRI guided bilateral cZI deep brain stimulation implantation. @entity1 were assessed by applying the Fahn-Tolosa-Marin Tremor Rating Scale and the Short Form Health Survey-36 (SF-36) to assess quality of life. RESULTS: The total @entity400 score improved by 73.8% (p<0.0001). The part A score (items 1-9) improved by 86.6% (p<0.0001). Postural @entity400 improved by 88.2% (p<0.0001) and action @entity400 by 82.2% (p<0.0001). The part B score, which evaluates the functional activities of the upper limbs, improved by 60.1% (p<0.0001). Part C score, which evaluates the activities of daily living, improved by 80.0% (p<0.0001). The SF-36 physical component score improved by 23.7% (p<0.0001) and the mental component score by 22.4% (p<0.0001). There was one wound infection and three @entity1 developed stimulation related transient @entity4653 . None developed any disequilibrium or tolerance to stimulation. CONCLUSION: Bilateral cZI stimulation is safe and effective in suppressing the postural and action component of ET. It is associated with a low incidence of stimulation related complications and @entity1 do not develop tolerance to stimulation with maintained clinical benefit over a follow-up period of up to 7 years.
