Association of the neuronal nicotinic XXXX receptor subunit alpha4 polymorphisms with @entity410 .

@entity1 @entity6344 @entity410 @entity72787 @entity302 @entity6786 @entity4940 @entity528 @entity934
PURPOSE: The alpha4-subunit gene of the neuronal nicotinic @entity934 receptor ( @entity6786 ) has been identified as the first gene underlying an idiopathic @entity302 in @entity1 @entity4940 . Studies provided evidence that the protein coded by @entity6786 is one of the most abundant subunits of the neuronal nicotinic @entity934 receptors in @entity1 brains, and mutations of @entity6786 seem to cause @entity528 . The @entity6786 gene may have a role in the development of @entity410 ( @entity410 ), the majority of childhood @entity410 . This study assessed the distribution of genotypes of @entity6786 in @entity1 with @entity410 . METHODS: A total of 102 @entity1 with @entity410 and 80 normal control subjects were included in the study. Polymerase chain reaction was used to identify the @entity6344 polymorphism of the @entity6786 gene. Genotypes and allelic frequencies for the @entity6786 gene polymorphisms in both groups were compared. RESULTS: The number of individuals with heterozygous @entity6786 ( @entity72787 )-C/T genotype was significantly greater (60.8% vs. 32.5%; p = 0.001), and the @entity6786 ( @entity72787 )-T allele frequency was significantly higher (p = 0.001), in @entity1 with @entity410 compared with healthy controls. The odds ratio for developing @entity410 in individuals with the @entity6786 ( @entity72787 )-CT genotype was 3.77 compared with individuals with two copies of the @entity6786 ( @entity72787 )-C allele. CONCLUSIONS: This study demonstrated an association between the @entity6786 gene and @entity410 . Individuals with the T allele had a higher incidence of @entity410 . These data suggest that the @entity6786 gene or a closely linked gene might be one of the susceptibility factors for @entity410 .
