Early evaluation of @entity1740 in XXXX (T1, T2) following curative radiotherapy.

@entity1 @entity189 @entity1740 @entity5
BACKGROUND: This is prospective study analyzing the subjective and objective quality of voice and voice related quality of life in @entity1 of early @entity5 (T1, T2 disease) before and after receiving curative radiotherapy. METHODS: Fifteen @entity1 of early @entity189 (T1, T2) underwent voice assessment using multidimensional voice protocol based on recommendation by European Laryngological Society which included Perceptual analysis of voice by speech therapist and otolaryngologist, acoustic analysis; aerodynamic efficiency analysis-Maximum phonation time; @entity1 's self perception of voice analysis--Voice handicap index; and videolaryngostroboscopy. Assessment was done prior to commencement of radiation therapy and at 1 month and 3 months following radio- therapy. RESULTS: There was significant improvement in majority of the voice parameters post radiotherapy. Perceptual analysis showed significant improvement in GRBAS score following radiotherapy. Perturbation measures (jitter, shimmer, SNR, HNR) showed improvement post radiotherapy though remained inferior compared to controls. Mean fundamental frequency (Mean F0) and habitual frequency (habitual F0) decreased post radiotherapy. Intensity of voice increased following radiotherapy which was statistically significant (p < 0.05). There was significant improvement in the @entity1 's perception of their quality of voice and voice related quality of life post radiotherapy. Maximum phonation time showed statistically significant improvement post-radiotherapy. Perceptual analysis of voice by professional observer correlated well with @entity1 self perception of his own voice. CONCLUSION: Voice quality improves following radiotherapy but not all the @entity1 regain normal voice. Improvement in @entity1740 improves quality of life of @entity1 shown by improved voice handicap index.
