Clinicopathologic significance of defective DNA mismatch repair in XXXX .

@entity1204 @entity1 @entity124 @entity5 @entity3
PURPOSE: Defective DNA mismatch repair is commonly present in sporadic manifestations of @entity1204 . The pathognomonic molecular manifestation of this repair defect is @entity124 ( @entity124 ). Here, we test the hypothesis that @entity124 predicts the clinicopathologic features of @entity1204 . @entity1 AND METHODS: A retrospective cohort of 473 @entity1 treated for @entity1204 at this institution was identified. All cases were reviewed by a gynecologic pathologist, and clinical information was abstracted from medical records. Using consensus criteria, DNA samples from nontumor and @entity5 tissue pairs were genotyped for @entity124 . Associations between @entity124 status and pathologic and clinical variables were assessed. RESULTS: Ninety-three (20%) of 473 @entity5 were @entity124 +. In the @entity124 + @entity5 group compared with the @entity5 group, the proportion of advanced compared with early-stage @entity5 was higher (92% v 81%; P = .01), as was the proportion of @entity5 of endometrioid compared with nonendometrioid histologic subtype (94% v 23%; P = .001), and the proportion of @entity5 with @entity3 compared with those with none (92% v 78%; P = .01). By multivariate analyses, disease-free survival (hazard ratio, 0.3; 95% CI, 0.2 to 0.7) and disease-specific survival (hazard ratio, 0.3; 95% CI, 0.1 to 0.8) were significantly improved in @entity1 with @entity124 + @entity5 . CONCLUSION: In @entity1204 , the presence of @entity124 was independently associated with a more favorable clinical outcome.
