Photoinduced Dynamics and XXXX of a Cancer Drug in Proximity of Inorganic Nanoparticles under Visible Light.

@entity137 @entity26 @entity1947 @entity33196 @entity98 @entity1948
UNASSIGNED: Drug sensitization with various inorganic nanoparticles (NPs) has proved to be a promising and an emergent concept in the field of nanomedicine. Rose bengal (RB), a notable photosensitizer, triggers the formation of reactive @entity26 species under green-light irradiation, and consequently, it induces @entity137 and cell death. In the present study, the effect of photoinduced dynamics of RB upon complexation with semiconductor @entity1947 NPs is explored. To accomplish this, we successfully synthesized nanohybrids of RB with @entity1948 NPs with a particle size of 24   nm and optically characterized them. The uniform size and integrity of the particles were confirmed by high-resolution transmission electron microscopy. UV/Vis absorption and steady-state fluorescence studies reveal the formation of the nanohybrids. ultrafast picosecond-resolved fluorescence studies of RB- @entity1948 nanohybrids demonstrate an efficient electron transfer from the photoexcited drug to the semiconductor NPs. Picosecond-resolved F  rster resonance energy transfer from @entity1948 NPs to RB unravel the proximity of the drug to the semiconductor at the molecular level. The photoinduced ROS formation was monitored using a @entity33196 oxidation assay, which is a conventional oxidative stress indicator. It is observed that the ROS generation under green light illumination is greater at low concentrations of RB- @entity1948 nanohybrids compared with free RB. Substantial photodynamic activity of the nanohybrids in bacterial and fungal cell lines validated the in vitro @entity137 results. Furthermore, the cytotoxic effect of the nanohybrids in HeLa cells, which was monitored by @entity98 assay, is also noteworthy.
