Hematopoietic growth factor inducible neurokinin-1 ( @entity37911 / @entity37911 ) is a biomarker of progressive XXXX across species.

@entity1 @entity644 @entity8 @entity851 @entity6 @entity3839 @entity740 @entity1188 @entity37911 @entity1011 @entity15901
We sought to find a urinary biomarker for @entity740 and tested @entity851 ( @entity851 , also known as @entity37911 / @entity37911 ) as it was found to be a @entity8 biomarker in microarray studies. Here, we studied whether @entity851 is a marker of @entity8 progression. Its @entity8 was confirmed by real-time PCR after 5/6 nephrectomy, in @entity3839 -induced @entity6 , and in @entity1 with @entity740 . In the remnant kidney, @entity851 mRNA increased over time reflecting lesion chronicity. @entity851 was identified in the @entity1188 in infiltrating hematopoietic interstitial cells, and in distal nephron tubules of the viable remnant kidney expressed de novo with increasing time. In vitro, it localized to cytoplasmic vesicles and cell membranes. Epithelial cells lining distal tubules and sloughed luminal tubule cells of @entity1 expressed @entity851 protein. The urine @entity851 -to- @entity1011 ratio increased over time after 5/6 nephrectomy; increased in @entity1 with @entity8 ; and remained detectable in urine after prolonged freezer storage. The urine @entity851 -to- @entity1011 ratio compared favorably with the urine @entity15901 ( @entity15901 )-to- @entity1011 ratio (both measured by commercial enzyme-linked immunosorbent assays (ELISAs)), and correlated strongly with @entity644 , but weakly with estimated glomerular filtration rate and serum @entity1011 . Thus, @entity851 may be a biomarker of progressive @entity8 .
