Acute effects of @entity13621 with or without a meal, calcium-fortified juice and a dairy product meal on serum calcium and XXXX : a randomised cross-over trial.

@entity1 @entity78 @entity4613 @entity13621 @entity3736 @entity9495
@entity9495 supplements, but not dietary @entity9495 , have been associated with increased cardiovascular risk. This difference could be related to differences in their acute effects on serum @entity9495 . We therefore examined the effects of @entity9495 from different sources on serum @entity9495 and @entity4613 in a randomised, cross-over trial of ten @entity1 (mean age of 69 years). Fasting @entity1 received a single dose of 500 mg of @entity9495 as @entity3736 , @entity3736 with a meal, fortified juice or a dairy product meal, with at least 6 d between each intervention. Blood was sampled before and 1, 2, 4 and 6 h after each intervention was ingested. Serum ionised and total @entity9495 increased significantly from baseline over 6 h. Using @entity13621 fasting as a comparator, the elevations in ionised and total @entity9495 were similar after fortified juice, delayed after @entity13621 with a meal and smaller after a dairy product meal. Serum @entity4613 and @entity78 product increased from baseline after @entity13621 with a meal and after a dairy product meal, and they declined after @entity13621 fasting and after fortified juice. The elevations in serum @entity9495 in the present study were only slightly different from those observed after the administration of 1000 mg of @entity9495 in a previous study. These data indicate that different sources of @entity9495 have different acute effects on serum @entity9495 and support recommendations that dietary @entity9495 might be safer than supplements. Whether these differences contribute to differences in cardiovascular risk requires further study.
