XXXX levels and their association with cardiovascular profile in @entity1 with @entity309 : a cross-sectional study.

@entity1 @entity410 @entity309 @entity26 @entity1674 @entity65 @entity165
OBJECTIVE: The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal @entity26 uptake (VO2max) test] with @entity65 ( @entity65 ) risk factors in @entity1 with @entity309 . METHODS: A total of 150 @entity309 @entity1 were assessed for @entity410 with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel @entity65 risk factors [blood pressure, body fat, insulin resistance, @entity165 , @entity1674 , high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year @entity65 risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases. RESULTS: Mean VO2max for all @entity309 @entity1 was 20.9 (s.d. 5.7) ml/kg/min. The 10-year @entity65 risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year @entity65 risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity. CONCLUSION: VO2max levels are alarmingly low in @entity309 @entity1 . Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve @entity410 in @entity309 .
