Dose-response relationships of serum lipid measurements with the extent of XXXX . Strong, independent, and comprehensive. ECAT Angina Pectoris Study Group.

@entity1 @entity301 @entity1674 @entity3452 @entity3979 @entity951 @entity1675 @entity453 @entity165
Serum lipids, lipoproteins, and more recently apolipoproteins and @entity3452 [ @entity3452 ] have been shown to be independent risk factors for @entity301 and its prognosis. However, the relationships between serum lipid levels and the extent of @entity453 ( @entity453 ) have not been consistently shown. Twenty-five hundred male and female @entity1 with suspected @entity951 were recruited from 18 European medical centers. The independent relations of total @entity165 , @entity1674 , HDL @entity165 , LDL @entity165 , @entity1675 , and @entity3452 with the presence and extent of @entity453 , as assessed by coronary angiography, were investigated. All of the lipid measures showed strong relations P < .0001) with the presence of @entity453 , defined by the existence of at least one > or = 50% @entity3979 . Total @entity165 , LDL @entity165 , apo B, @entity1674 , and @entity3452 were substantially higher and HDL @entity165 and @entity1675 -I lower in @entity1 with @entity453 . The odds ratio of @entity453 , in the high-risk tertile of each lipid's distribution compared with the low-risk tertile, was in the range 1.5 to 2.3. Each of total @entity165 (or LDL @entity165 or apo B), HDL @entity165 (or @entity1675 ), and @entity3452 had an independent effect in predicting the presence of @entity453 . In addition, all lipids showed a strong association (P = .0006 for @entity1674 , P < .0001 otherwise) with the extent of @entity453 as defined by the number of stenosed coronary vessels.(ABSTRACT TRUNCATED AT 250 WORDS)
