Urinary C-Peptide/Creatinine Ratio Can Distinguish Maturity-Onset @entity6 in XXXX and Adolescents: A Single-Center Experience.

@entity1 @entity6 @entity2175
BACKGROUND: The urinary C-peptide/creatinine ratio (UCPCR) and fasting C-peptide level can assess beta-cell function in clinical practice. In the present study, the use of the UCPCR and fasting C-peptide levels was investigated in the differential diagnosis between maturity-onset @entity6 (T1DM). METHODS: Twenty-seven @entity1 with genetically confirmed @entity2175 by next-generation sequence analysis and 42 @entity1 with T1DM were included. C-peptide levels were measured after an overnight fast before breakfast, and urine samples were collected 2 h after a standard lunch in the hospital. RESULTS: The UCPCR in the T1DM group was 0.17    0.5 nmol/mmol, and in the @entity2175 group it was 1.27    1.03 nmol/mmol (p = 0.001). The receiver operating characteristic (ROC) curves showed excellent discrimination (area under the curve 0.93). A UCPCR >= 0.22 nmol/mmol yielded a 96.3% sensitivity and an 85.7% specificity. The fasting C-peptide level in the T1DM group was lower than that in the @entity2175 group (p = 0.001). The fasting C-peptide cutoff determined by ROC curve analysis was 0.62 ng/ml, with a sensitivity of 93% and a specificity of 90% for discriminating between @entity2175 and T1DM. CONCLUSIONS: We showed that the UCPCR and fasting C-peptide levels in @entity1 and adolescents can distinguish @entity1 with @entity2175 from @entity1 with T1DM with high specificity and sensitivity. A value of UCPCR >= 0.22 nmol/mmol may indicate further genetic testing for @entity2175 .    2015 S. Karger AG, Basel.
