Influence of XXXX on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality.

@entity28 @entity2204 @entity755 @entity1144 @entity412 @entity42000 @entity165
UNASSIGNED: Background. @entity2204 plays a key role in the handling of lipoprotein particles with @entity2204 and @entity2204 frequently having opposite effects compared to @entity2204 . Some individuals simultaneously carry both E2 and E4 alleles. The impact of the @entity2204 /4 genotype on lipid concentrations and its consequences on health remain poorly documented. Objective. This study compared the lipid profile between @entity2204 /4 carriers and other @entity2204 genotypes in relation to the waist circumference. Methods. @entity165 , @entity412 (TG), and @entity755 concentrations were measured among 2,680 Caucasians. Multivariate logistic regression models were used to estimate the contribution of @entity2204 /4 to various dyslipidemic profiles associated with @entity1144 . Results. In presence of @entity1144 , the lipid profile was as deteriorated in @entity2204 /4 carriers as in carriers of other @entity2204 genotypes. There was a more pronounced effect on TG-rich lipoproteins, particularly in @entity2204 (a feature of @entity42000 ), and non-high-density lipoprotein (HDL) @entity165 in @entity2204 /4. Compared to @entity2204 , @entity2204 /4 carriers presented lower very-low-density lipoprotein (VLDL) @entity165 concentrations and VLDL- @entity165 /TG ratios, with or without @entity28 , and higher low-density lipoprotein (LDL) @entity165 concentrations. Conclusion. In presence of @entity1144 , the influence of the @entity2204 allele could be less pronounced than that of @entity2204 among @entity2204 /4 individuals.
