The role of insulin-like growth factor in prediction and prevention of XXXX .

@entity1 @entity6677 @entity10116 @entity3152
BACKGROUND/AIM: Prediction and prevention of @entity3152 remain great challenge. It is important to include in everyday medical practice determination of certain markers that could help identifying pregnant @entity1 with @entity3152 . Insulinlike growth factor (IGF) is involved in the control mechanism of fetal and placental growth and development. The aim of this study was to examine the presence of @entity10116 ( @entity10116 ) in cervicovaginal secretion of pregnant @entity1 with symptoms of @entity3152 , but with apparently intact fetal membranes and to point out a possible application of the strip test for detection of phlGFBP-1 in diagnosis of preterm premature rupture of total membranes (PPROM) in everyday medical practice. METHODS: The study was performed at the Department for Obstetrics and Gynecology, Clinical Center of Vojvodina between October 2008 and May 2009. The study included 54 pregnant @entity1 between 20-35 @entity6677 ( @entity6677 ), divided into two groups: the study group (16 pregnant @entity1 with symptoms of @entity3152 that gave birth before 37 @entity6677 ) and the control group (38 pregnant @entity1 with the normal course of pregnancy that gave birth on term). In cervicovaginal secretion of the examined pregnant @entity1 the level of @entity10116 was determined by the immunochromatographic assay with monoclonal antibodies 6303 as a detecting antibody (Actim PROM test, Medix Biochemica, Kauniainen, Finland). RESULTS: Gestational age (GA) at delivery in the study group was 32.6 @entity6677 and in the control group it was 38.4 @entity6677 . Weight of newborns in the study group was 2,021 g and in the control group 3,430 g. IGFBP test was positive in 15 @entity1 (93.75%) of the study group, while in the control group it was positive only in 1 @entity1 (2.63%). CONCLUSION: Test on phIGFBP-1 in cervicovaginal mucus was positive in 93.75% @entity1 with @entity3152 , suggesting that this test could be used in diagnosis of silent rupture of fetal membranes and in prediction of @entity3152 .
