The long-term efficacy of combined chemoembolization and local irradiation in the treatment of @entity1 with large XXXX .

@entity1 @entity137 @entity5 @entity160 @entity157
BACKGROUND/AIMS: To investigate the effects and @entity137 of combined transcatheter arterial chemoembolization and local radiotherapy for @entity1 with unresectable @entity157 . METHODOLOGY: From June 1994 to June 1999, 28 @entity1 with unresectable @entity157 (the largest dimension of @entity5 ranged from 3 to 10 cm) were treated with transcatheter arterial chemoembolization followed by local irradiation. Response was assessed by computed tomography scan and ultrasound, together with serum @entity160 level in cases with increased baseline values. Complications associated with treatment were monitored. Cumulative survival was determined by Kaplan-Meier method from the first day of treatment. RESULTS: An objective response (reduction of @entity5 area greater than 50%) was achieved in 57.0% of the cases. In 63.0% of the cases with increased @entity160 values, @entity160 level underwent a marked reduction (more than 50%). The cumulative survival rates at 1, 3, and 5 years were 81.9%, 42.4%, and 21.2%, respectively (median survival, 31 months, 95% CI: 27.8-34.2 months). The combination therapy was generally well tolerated. CONCLUSIONS: The results suggest that combined transcatheter arterial chemoembolization with local radiotherapy is an effective and safe treatment for unresectable @entity157 . Further study is required to compare the therapeutic efficacy of this regimen to transcatheter arterial chemoembolization or radiotherapy alone.
