Association between XXXX promoter polymorphism and recovery from concussion.

@entity1 @entity11588 @entity3391 @entity1422
OBJECTIVE: To determine genetic variability within the @entity3391 receptor 2A sub-unit ( @entity11588 ) gene promoter and its association with concussion recovery time. The hypothesis tested was that there would be a difference in allele and/or genotype distribution between two groups of athletes with normal and prolonged recovery. METHODS: DNA was extracted from saliva collected from a total of 87 athletes with a physician-diagnosed concussion. The ( @entity1422 ) variable number tandem repeats (VNTR) within the promoter region of @entity11588 was genotyped. The long (L) allele was an allele with >= 25 repeats and the short (S) allele was an allele with <25 repeats in the @entity1422 tract. @entity1 ' recovery time was followed prospectively and was categorized as normal ( <=60 days) or prolonged (>60 days). RESULTS: LL carriers were 6-times more likely to recover longer than 60 days following the concussive event (p   =   0.0433) when compared to SS carriers. Additionally, L allele carriers were found more frequently in the prolonged recovery group (p   =   0.048). CONCLUSION: Determining genetic influence on concussion recovery will aid in future development of genetic counselling. The clinical relevance of genotyping athletes could improve management of athletes who experience concussion injuries.
