The influence of XXXX and socioeconomic status on platelet activation in @entity1 .

@entity1 @entity1423 @entity301 @entity1642 @entity65
OBJECTIVE: Circulating monocyte- and neutrophil-platelet aggregates are sensitive markers of in vivo platelet activation. Socioeconomic status is inversely associated with risk of @entity301 . We assessed the impact of @entity1642 on @entity1423 in @entity1 from higher and lower socioeconomic status groups. METHODS: @entity1 were 37 healthy non-smoking @entity1 aged 30-59 years, divided by occupation into higher and lower social status groups. Blood was drawn at baseline, immediately following stressful behavioural tasks, and at 30 and 75 min post-stress, and aggregates were analysed using flow cytometry. Cardiovascular and subjective stress responses were also monitored. RESULTS: There were significant increases following stress in monocyte-, neutrophil-, lymphocyte- and total @entity1423 (all P<0.05). The largest responses were in monocyte-platelet (21% increase) and neutrophil-platelet (16.7% increase) aggregates. Lower socioeconomic status @entity1 had greater numbers of @entity1423 throughout, but the magnitude of stress responses did not vary with social status. The increase in monocyte- and @entity1423 was associated with systolic blood pressure stress responsivity. CONCLUSIONS: Psychological stress induces platelet activation as indexed by @entity1423 , and correlations with cardiovascular stress reactions suggest that sympathoadrenal responses may be responsible. Platelet activation may be a mechanism through which social position influences @entity65 risk.
