Postnatal-onset XXXX : pathogenesis, patterns of growth, and prediction of outcome.

@entity1 @entity135 @entity9670 @entity168 @entity6694 @entity4242 @entity214
OBJECTIVE: Although @entity1 with postnatal-onset @entity4242 (POM) generally have poor development, we speculated that better somatic growth would predict better development in these @entity1 . @entity1 AND METHODS: We followed 57 @entity1 with POM for an average of 4.2 years (13 @entity9670 , 14 dysgenetic, 6 with @entity6694 , 24 idiopathic) and calculated the developmental quotient (DQ) at each visit (DQ > 0.70 was considered normal). @entity168 scores ( @entity214 ) for measurements were analyzed using a repeated measures mixed-effects model to assess effect of weight, height, @entity135 ( @entity135 ), and age on DQ. Pearson's correlation was used to examine the independent influence of each variable on final DQ. RESULTS: Forty-four @entity1 (77%) had a low DQ (mean: 0.33), but 13 (23%) had a normal DQ (mean: 0.93), including 10 idiopathic and 3 @entity9670 . Mean @entity135 fell below -2 @entity214 in all before 1 year (destructive at 3.3 months, idiopathic low-DQ at 7.5 months, dysgenetic at 8.5 months, @entity6694 at 11 months, and idiopathic normal-DQ at 11.5 months). Mean weights and heights both fell below -2 @entity214 for all low-DQ groups but remained normal in both normal-DQ groups. Weight, height, and @entity135 were independent predictors of DQ (P < .0001). Final DQ correlated with weight (r = 0.27), height (r = 0.41), and @entity135 (r = 0.13). CONCLUSIONS: Most @entity1 with POM have poor later development. Whatever the cause of POM, @entity1 in whom postnatal body growth (weight, height, @entity135 ) is better sustained have more favorable development, and in one-quarter of such @entity1 (mostly idiopathic POM), final DQ is normal.
