Variable asialoglycoprotein-receptor 1 expression in XXXX : Implications for therapeutic intervention.

@entity1 @entity96 @entity409 @entity34049 @entity157
AIM: One of the most promising strategies for the treatment of @entity409 is targeted drug delivery via the @entity34049 ( @entity34049 ). The success of this approach heavily depends on the @entity34049 expression level on parenchymal liver cells. In this study, we assessed the mRNA and protein expression levels of the major receptor subunit, @entity34049 , in hepatocytes both in vitro and in vivo. METHODS: In vitro, various @entity96 -derived cell lines were evaluated. In vivo, we screened the @entity34049 mRNA on 59 @entity157 and matched non-neoplastic tissue using RNA microarray. In addition, 350 @entity1 liver specimens of @entity1 with @entity157 or non-neoplastic @entity409 were screened for @entity34049 protein level using tissue microarray analysis. RESULTS: Our data reveal that the @entity34049 mRNA expression directly correlates with the protein level. We demonstrate that the @entity34049 expression is upregulated in cirrhotic specimens and is significantly decreased with increasing @entity157 grade. CONCLUSIONS: Since the @entity34049 expression levels are variable between @entity1 , our findings suggest that @entity34049 -based targeting strategies should be combined with @entity34049 -companion diagnostics to maximize clinical benefit. This article is protected by copyright. All rights reserved.
