A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal XXXX reveals frequently involved chromosome segments as well as significant age- and sex-related differences.

@entity1582 @entity1 @entity1692 @entity5
The cytogenetic features (ploidy, complexity, breakpoints, imbalances) were ascertained in 783 abnormal @entity1582 ( @entity1582 ) cases to identify frequently involved chromosomal regions as well as a possible impact of age/sex. The series included @entity1582 @entity1 from the Mitelman Database of Chromosome Aberrations in @entity5 and from our own laboratory. Hyperdiploidy was most common, followed by hypodiploidy, pseudodiploidy and tri-/tetraploidy. Most cases were complex, with a median of eight changes per @entity1 . The distribution of modal numbers differed between younger and older @entity1 , but was not related to sex. No sex- or age-related differences regarding the number of anomalies were found. The most frequent genomic breakpoints were 14q32, 11q13, 1q10, 8q24, 1p11, 1q21, 22q11, 1p13, 1q11, 19q13, 1p22, 6q21 and 17p11. Breaks in 1p13, 6q21 and 11q13 were more common in the younger age group. The most frequent imbalances were + 9, - 13, + 15, + 19, + 11 and - Y. @entity1692 were more common among @entity1 , while -X was more frequent among @entity1 . Loss of Y as the sole change and + 5 were more common in elderly @entity1 , and - 14 was more frequent in the younger age group. The present findings strongly suggest that some karyotypic features of @entity1582 are influenced by endogenous and/or exogenous factors.
