Topical, Aqueous, Clear XXXX Formulation Design for Anterior and Posterior Ocular Delivery.

@entity1 @entity9472 @entity137 @entity267 @entity6000 @entity9849 @entity95 @entity205
PURPOSE: The main objective of this study was to optimize @entity205 ( @entity9472 ) nanomicellar solution and study in vivo ocular @entity9472 tissue distribution with a topical drop. METHODS: An optimized blend of hydrogenated castor oil-40 and @entity6000 -40 was prepared to entrap @entity9472 within nanomicelles. In vivo studies were conducted in New Zealand White albino @entity95 with topical drop instillation. RESULTS: Average size of @entity9472 -loaded nanomicelles was approximately 22.4 nm. Ocular tissue @entity9472 quantification with single and multiple dosing revealed that @entity9472 levels followed as @entity267  >  iris-ciliary body  >  aqueous humor  >  lens. @entity205 levels were also found to be in the following order: conjunctiva  >  sclera  >  retina/choroid  >  vitreous humor. High @entity9472 level was detected in retina/choroid (53.7 ng/g tissue). CONCLUSIONS: Ocular tissue @entity9472 distribution studies revealed high @entity9472 concentrations in anterior ocular tissues. Moreover, it appears that nanomicelles are transported through a conjunctival-scleral pathway and deliver @entity9472 to the retina/choroid. Results suggest polymeric blend to be a safe carrier for anterior and posterior ocular tissues. TRANSLATIONAL RELEVANCE: This study has significant translational relevance, disclosing results that suggest that aqueous nanomicellar approach can provide high corneal and conjunctival @entity9472 concentrations. Aqueous nanomicelles can deliver high drug concentrations not only to anterior but also to back of the eye tissues, including retina. This article provides a platform for noninvasive back of the eye drug delivery with topical eye drops. Aqueous @entity9472 nanomicelles have no perceptible @entity137 such as cell membrane damage or @entity137 to corneal and retinal pigment epithelial cells. Clear aqueous nanomicellar solution can be translated to @entity1 conditions for @entity9849 sicca and other anti-inflammatory conditions.
