Prognostic implications of anatomic location of primary XXXX of 1 mm or thicker.

@entity1 @entity5 @entity13177 @entity1066 @entity2045 @entity1600 @entity320 @entity1349
BACKGROUND: Breslow thickness, @entity1066 , and @entity1600 ( @entity1600 ) status are well established as the most important prognostic factors for @entity1 with @entity320 . Anatomic location of the @entity5 is generally considered to play a minor role in determining prognosis compared with these other factors. This analysis was performed to better define the influence of anatomic location of the primary @entity320 on prognosis. METHODS: In this post hoc analysis of a prospective randomized trial that included @entity1 ages 18 to 70 years with @entity320 1 mm or greater in Breslow thickness, all @entity1 underwent @entity1600 biopsy and completion lymphadenectomy if @entity5 -positive @entity1600 were found. Kaplan-Meier survival analysis and univariate and multivariate analyses were performed to evaluate factors predictive of disease-free survival (DFS), @entity13177 ( @entity13177 ), and @entity1349 ( @entity1349 ). RESULTS: A total of 2,500 @entity1 were included in this analysis with a median follow-up period of 68 months. Anatomic locations included head, neck, trunk, @entity2045 , and lower extremity. Age, Breslow thickness, and percentage of @entity1 with a positive @entity1600 were significantly different by anatomic location on univariate analysis, as were positive @entity1600 status, presence of regression, sex, and histologic subtype (P < .0001). On multivariate analysis, anatomic location was an independent predictor of @entity1600 status (P < .0001), DFS (P = .045), @entity13177 (P = .023), and @entity1349 (P < .0001). By Kaplan-Meier analysis, anatomic location was associated significantly with DFS, @entity13177 , and @entity1349 . CONCLUSIONS: Anatomic location of the primary @entity320 is an important independent predictor of @entity1600 status and prognosis. @entity1 with primary @entity320 of the head/neck and trunk have a worse prognosis than primary @entity320 of other anatomic locations.
