Cell cycle progression score predicts metastatic progression of XXXX after resection.

@entity5 @entity1 @entity1358 @entity3
BACKGROUND: The outcome of surgically resected, apparently localized, @entity1358 ( @entity1358 ) is uncertain. OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future @entity3 . METHODS: Pathologic T2a-T3b @entity5 at University of (X) were reviewed. @entity1 with known or suspected @entity3 , lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop @entity3 within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the @entity5 were calculated as a CCP score. Additionally, gene expression data for a separate @entity1358 cohort was downloaded from The @entity5 (TCGA). RESULTS: Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to @entity3 (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant @entity3 in the @entity5 cohort in both univariate (p = 1.0 * 10-9) and multivariate (p = 5.6 * 10-3) analysis. CONCLUSION: The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined @entity1358 .
