Age- and sex-dependent distribution of OGTT-related variables in a population of XXXX @entity1 .

@entity1 @entity5174 @entity6 @entity1577 @entity2690 @entity1720 @entity413
CONTEXT: @entity1577 ( @entity1577 ) causes an exceptionally high prevalence of @entity6 that increases with age, especially in females. The @entity413 tolerance defect is progressive but a @entity5174 -dependent insulin secretory defect cannot be excluded. The age and sex dependence of the secretory defect is unclear. OBJECTIVE: To analyze the age and sex dependency of insulin secretory and sensitivity parameters in @entity1577 . DESIGN: Cross-sectional analysis in an observational ongoing cohort (mean follow-up duration 7.5yr). SETTING: @entity1577 Center of Milan. @entity1 : 187 @entity1 aged 8-30yr. INTERVENTION: 3-hour Oral @entity413 Tolerance Tests (OGTT, n=478) with 30-min insulin and @entity2690 sampling. MAIN OUTCOME MEASURES: model-derived insulin secretory and sensitivity parameters. RESULTS: Age was associated to a progressive decrement in insulinemia (at 30min) and a subsequent increment in glycemia (at 60-90min) returning at or below baseline (at 180min). These changes are explained by a progressive reduction in beta-cell sensitivity to @entity413 and a progressive increment in insulin clearance. Fasting and postprandial insulin sensitivity do not seem to be involved. Compared to males, females display higher @entity413 , insulin and @entity2690 responses with greater insulin secretion, beta-cell sensitivity to @entity413 , insulin clearance and @entity1720 . CONCLUSIONS: A defect in beta-cell sensitivity to @entity413 progressively develops with age, but it is not sex specific and does not explain the worse @entity413 tolerance reported in females. In contrast, insulin clearance increases with age, especially in females, contributing to deterioration in @entity413 tolerance. The effects of age and sex should be considered when evaluating OGTT results in @entity1577 @entity1 .
