ST segment and T wave characteristics as indicators of XXXX risk: the Zutphen Study.

@entity1 @entity308 @entity301 @entity944 @entity951 @entity299 @entity583
OBJECTIVES: This study evaluated the predictive value of T wave amplitude and ST segment level on lead I for @entity951 , a first @entity583 , @entity944 and @entity301 in middle-aged and elderly @entity1 . BACKGROUND: Certain ST-T wave characteristics may reflect favorable autonomic cardiac control. Slight ST segment elevation has been reported to indicate a low risk of @entity301 mortality. METHODS: A total of 876 @entity1 , born between 1900 and 1920, participated in periodic medical examinations and were followed up with respect to morbidity and mortality from 1960 to 1985. In 1985, the remaining cohort was extended to 836 elderly @entity1 from the same birth cohort who were followed up until 1990. Relative risks in categories of T wave amplitude and ST segment level were estimated by survival analysis. RESULTS: Both middle-aged and elderly @entity1 with T wave amplitudes > or = 0.15 mV had a lower risk of @entity583 , @entity301 and @entity944 than @entity1 with T wave amplitudes 0.05 to 0.15 mV. The adjusted relative risk of @entity301 was 0.5 (95% confidence interval [CI] 0.2 to 1.0); in @entity1 with T wave amplitude < or = 0.05 mV, relative risk was 2.0 (95% CI 1.3 to 3.1). Slight ST segment elevation was also associated with decreased risk: relative risk 0.5 (95% CI 0.3 to 1.0) compared with the isoelectric ST segment level. In @entity1 with ST segment @entity308 , relative risk was 2.2 (95% CI 1.4 to 3.4). The association of T wave amplitude and ST segment level were independent of each other. CONCLUSIONS: In addition to the elevated risk of @entity301 that is associated with ST-T wave abnormalities, we observed that normal variations in repolarization characteristics are predictive of future @entity299 .
