Inheritance of XXXX and @entity8 in Newfoundlands.

@entity8 @entity1522 @entity8324 @entity235 @entity535 @entity1854 @entity7222 @entity3833 @entity376 @entity1434 @entity1011 @entity1876 @entity369
OBJECTIVE: To describe clinical features, characterize @entity8 , and evaluate mode of inheritance of @entity8324 in Newfoundlands. DESIGN: Prospective study. ANIMALS: Two families of Newfoundlands including 11 @entity235 with @entity3833 , stranguria, or obstruction attributable to @entity1434 calculi. PROCEDURE: Urinalysis and @entity1854 spot tests were performed to evaluate @entity8324 in the affected @entity235 . All calculi were analyzed by crystallography. @entity535 concentrations in urine and plasma of affected @entity235 were compared with those in clinically normal related @entity235 . @entity8 and reabsorption of @entity1522 were determined in 5 affected Newfoundlands. RESULTS: Nine @entity235 had pure @entity1434 calculi in the bladder, and 4 of these had renal @entity1434 calculi. Affected @entity235 persistently excreted excessive amounts of @entity1434 (> 500 nmol/mg of @entity1011 ; reference = 54 +/- 38 nmol/mg of @entity1011 ) and had typical @entity1434 crystals in acidic urine. Urinary excretion of @entity7222 , @entity376 , and @entity369 was also high. @entity235 with @entity8324 had complete lack of reabsorption and active secretion of @entity1434 , and reabsorption of @entity376 , @entity7222 , and @entity369 was moderately impaired. Although clinical signs of @entity1876 were observed only in males, cystinuric male and female offspring were produced from noncystinuric parents, consistent with an autosomal recessive mode of inheritance. Obligate heterozygotes did not have clinical signs, and had normal urinary @entity1434 content and renal @entity535 reabsorption. CLINICAL IMPLICATIONS: Because detection of carriers by routine urinalysis is currently not possible, Newfoundlands with @entity8324 and their parents and offspring should be excluded from breeding.
