Clinical significance of serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in XXXX .

@entity1 @entity1552 @entity82 @entity17944 @entity1956 @entity1476 @entity56408 @entity409 @entity15803 @entity1549 @entity2843 @entity1575 @entity3619 @entity16617
OBJECTIVE: We have attempted to determine serum levels of type IV collagen (IV-C), laminin (LM), prolylhydroxylase (PH), metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in @entity409 to elucidate the clinical significance of MMPs and TIMPs in the process of @entity1575 . METHODS: Serum samples were collected from 60 @entity1 with @entity409 caused by @entity1956 or C. Serum levels of IV-C, LM, PH, @entity17944 , and @entity16617 were measured by a one-step sandwich enzyme immunoassay using monoclonal antibodies. The values were correlated with @entity15803 ( @entity15803 ) scores of liver biopsy specimens. RESULTS: LM and IV-C levels markedly increased in parallel with the progression of the @entity409 . The @entity1476 and @entity1549 levels tended to increase in @entity3619 ( @entity3619 ), and significantly elevated in @entity1575 ( @entity1575 ). There was a positive correlation between the IV-C and @entity1476 levels, and the ratio of IV-C to @entity1476 levels was significantly elevated in @entity1575 . Both @entity2843 and @entity1552 levels were markedly increased in @entity1575 . The @entity15803 scores were positively correlated with the serum IV-C and @entity1476 levels. CONCLUSIONS: Serum IV-C and @entity1476 levels may be useful diagnostic markers for @entity1575 , since they increased in parallel with the progression of @entity409 . In addition, the imbalances between IV-C, LM, and @entity16617 as fibrogenic factors and @entity56408 as fibrolytic factors may lead to @entity1575 , especially in @entity82 .
