The role of leukotoxin ( @entity71039 ) in the genesis of XXXX .

@entity235 @entity71039 @entity44836 @entity5642 @entity854 @entity281 @entity4722
This study was designed to clarify whether or not leukotoxin ( @entity71039 ), which is biosynthesized by neutrophils, might be involved in the genesis of @entity854 . Twelve @entity235 were divided into 2 groups. In the test group (n = 6), 100 mumol/kg of @entity44836 was injected intravenously, and in the control group (n = 6), 100 mumol/kg of @entity4722 was injected. In each group, a series of blood samples were collected and used for coagulation studies. After the end of the experimental period, a histological study was performed on organs removed from the @entity235 . In the leukotoxin group, fibrin and fibrinogen degradation products (FDP) was increased time-dependently. Fibrinogen was decreased, and prothrombin time and activated partial thromboplastin time were prolonged in parallel with the increase in FDP. A decrease in number of platelets was also observed. @entity5642 was observed in sections of lung. These data were compatible with a diagnosis of @entity5642 ( @entity5642 ). No significant changes in these parameters were observed in the @entity4722 group. @entity44836 has been confirmed to show antifungal and antibacterial activity, and its production might be a defensive response to @entity281 . Over-production of leukotoxin associated with severe @entity281 might therefore account for @entity5642 .
