Secretory proteins of the XXXX ( @entity3474 ) endometrium: regulation during the menstrual cycle and early pregnancy.

@entity3474 @entity1420 @entity21335
The biological function of uterine endometrial secretory proteins in the primate remain to be elucidated. In general, during the luteal phase and under @entity1420 dominance, the glandular epithelial cells synthesize and secrete a number of proteins. Of these, placental protein 14 (PP14; now referred to as glycodelin) and @entity21335 ( @entity21335 ) are the best characterized. Although induced by @entity1420 , their synthesis increases exponentially during pregnancy. In the @entity3474 , glycodelin is immunolocalized to the mid functionalis and basal glands between days 10 and 12 post-ovulation. In response to either exogenous or blastocyst-secreted chorionic gonadotrophin, glandular synthesis increases markedly and remains elevated up to days 18-25 of pregnancy. The decrease in glycodelin in the endometrium is associated with glandular regression during the first third of pregnancy. In contrast, @entity21335 is only observed in the deep basal glands during the luteal phase. Following the establishment of pregnancy, @entity21335 synthesis switches from glandular to stromal and is correlated with the process of decidualization. @entity21335 synthesis continues to increase throughout gestation. We propose that glycodelin may have immunosuppressive properties and that @entity21335 may regulate trophoblast migration within the uterine endometrium.
