3D.01: VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY INCREASES RISK OF STROKE OR CARDIAC EVENTS IN XXXX GIVEN @entity917 OR @entity3591 IN THE VALUE TRIAL.

@entity917 @entity1 @entity712 @entity64 @entity101 @entity3591 @entity299
OBJECTIVE: High blood pressure variability has been associated with an increased risk of cardiovascular events. We aimed to assess if increased visit-to-visit variability in systolic blood pressure increases the risk of @entity64 or @entity299 (fatal/non-fatal coronary or @entity712 events) in the VALUE population. DESIGN AND METHOD: The VALUE trial was a randomised-controlled, double-masked investigation of @entity917 versus @entity3591 in @entity1 50 years or older with @entity101 and high risk of cardiovascular events. Mean follow-up time was 4.2 years. We calculated the standard deviation (SD) of mean systolic blood pressure from visits from 6 months onward, excluding @entity1 with less than 2 visits, or @entity64 or @entity299 during the first 6 months. In the pooled treatment arms, we grouped SD in quintiles and compared the risk of @entity64 or @entity299 in the highest and the lowest quintile, using a Cox regression model, adjusting for a number of prognostic variables, including randomised treatment and mean BP from 6 months onwards. RESULTS: Of 14.146 @entity1 included, 1278 (9.0%) experienced a @entity299 and 473 (3.3%) experienced a @entity64 . Compared to @entity1 with the lowest variability, those in the highest quintile had an increased risk of @entity64 or @entity299 (HR 1.4, 95% CI 1.0-1.8, p=0.045 and HR 1.9, 95% CI 1.6-2.3, p<0.0001, respectively, Figure). CONCLUSIONS: Visit-to-visit systolic BP variability predicts @entity64 and @entity299 in high risk @entity101 @entity1 receiving @entity917 or @entity3591 , and independent of mean BP. Systolic blood pressure variability was a stronger predictor of @entity64 .(Figure is included in full-text article.).
