The behavior of @entity70960 in XXXX gastrointestinal tract as a prodrug.

@entity35 @entity70960 @entity13507 @entity1670
The gas chromatographic assay method for @entity70960 , a @entity1670 prodrug, and its hydrolysates was developed. The behavior of the drug in gastrointestinal tract was investigated in @entity35 by using the method. The disappearance and hydrolysis of the drug were not observed in the gastric loop until 30 min. The rate of disappearance from the intestinal loop was 36.7% at 30 min which was significantly smaller than that of @entity1670 . Little hydrolysis of the drug was observed in the buffer solution, pH 7.4, at 37 degrees up to 2 hr. However, the consecutive hydrolysis was observed when the drug was incubated with everted intestine or plasma. As to the rate of hydrolysis of the drug and its esterform hydrolysates by scraped intestinal mucosa, the @entity13507 to which the larger number of @entity1670 was bound was hydrolyzed more rapidly. These results indicate that the orally administered drug is enzymatically hydrolyzed in the intestinal mucosa by a consecutive reaction. Although the hydrolysis rate of @entity70960 is rapid, the rate of its @entity13507 -form hydrolysate becomes slower gradually as the @entity1670 is released. The released @entity1670 is rapidly absorbed. The behavior of the drug revealed in this study suggests that @entity70960 is useful as a prodrug of @entity1670 .
