Virilization of a female XXXX by a maternal @entity1636 .

@entity1 @entity2208 @entity4998 @entity1465 @entity5 @entity3428 @entity699 @entity134 @entity1636 @entity701 @entity342
OBJECTIVE: To describe a possible mechanism underlying the partial virilization of a 46, XX @entity1 by a functional maternal @entity1636 ( @entity1636 ). METHODS: We performed immunocytochemical staining of @entity5 sections for luteinizing hormone (LH)/ @entity1 chorionic gonadotropin ( @entity1465 ) receptors. In addition, related reports in the literature are discussed. RESULTS: A previously healthy mother developed a large @entity701 - and @entity342 -producing @entity5 that did not interfere with conception or early morphogenesis. The @entity5 eluded detection until after delivery of a partially virilized 46, XX female @entity1 with @entity4998 . Immunohistochemical staining of @entity5 sections revealed overexpression of the LH/ @entity1465 receptor. Virilization of the genetically female fetus may have resulted from @entity1465 -stimulated steroid secretion by the @entity1636 . CONCLUSION: Because @entity699 and @entity3428 are associated with menstrual disturbances and @entity2208 , pregnancy in @entity1 with functional @entity5 is uncommon. Rarely, maternal @entity134 excess from a functional @entity5 has caused 46, XX disordered sex differentiation. This unusual case demonstrates the influence of @entity1465 on the functionality of an @entity1636 and demonstrates the rare phenomenon of virilization of a female @entity1 by a functional maternal @entity5 .
