Effect of the metastatic defect on the structural response and failure process of XXXX vertebrae: An experimental study.

@entity1 @entity154 @entity174 @entity177 @entity158
BACKGROUND: Pathologic @entity174 are associated with intractable @entity158 , loss of function and high morbidity in @entity1 with metastatic spine disease. However, the failure mechanisms of vertebrae with @entity154 and the failed vertebrae's ability to retain load carrying capacity remain unclear. METHODS: Eighteen @entity1 thoracic and lumbar vertebrae with simulated uncontained bone defects were tested under compression-bending loads to failure. Failure was defined as 50% reduction in vertebral body height. The vertebrae were allowed to recover under load and re-tested to failure using the initial criteria. Repeated measure ANOVA was used to test for changes in strength and stiffness parameters. FINDINGS: @entity177 occurred via buckling and @entity174 of the cortex around the defect, followed by collapse of the defect region. Compared to the intact vertebrae, the failed vertebrae exhibited a significant loss in compressive strength (59%, p<0.001), stiffness (53%, p<0.05) and flexion (70%, p<0.01) strength. Significant reduction in anterior-posterior shear (strength (63%, p<0.01) and stiffness (67%, p<0.01)) and lateral bending strength (134%, p<0.05) were similarly recorded. In the intact vertebrae, apart from flexion strength (r(2)=0.63), both compressive and anterior-posterior shear strengths were weakly correlated with their stiffness parameters (r(2)=0.24 and r(2)=0.31). By contrast, in the failed vertebrae, these parameters were strongly correlated, (r(2)=0.91, r(2)=0.86, and r(2)=0.92, p<0.001 respectively). INTERPRETATION: Failure of the vertebral cortex at the defect site dominated the initiation and progression of vertebral failure with the vertebrae failing via a consolidation process of the vertebral bone. Once failed, the vertebrae showed remarkable loss of load carrying capacity.
