Time course differences for statin-induced pleiotropic effects in XXXX @entity1 .

@entity1 @entity4631 @entity753 @entity2993 @entity4466 @entity23260 @entity165
BACKGROUND: It is unclear whether there are temporal differences for the pleiotropic effects for different members of the statin class. The present study investigated differences in the short- and intermediate-term pleiotropic effects of statins in @entity753 @entity1 . METHODS: Thirty-five @entity753 @entity1 were randomly treated with either @entity2993 or @entity23260 for 3 months. We measured fasting lipid concentrations, @entity4466 reactive substances (TBARS), fibrinolytic parameters, and flow-mediated dilation of the brachial artery ( @entity4631 ) at baseline and after 2 weeks and 3 months of therapy. RESULTS: After 2 weeks of therapy, @entity2993 decreased the low density lipoprotein (LDL) @entity165 , small, dense LDL @entity165 (34+/-22 vs. 18+/-20%, P<0.01), remnant-like particles (RLP) @entity165 (8.8+/-6.0 vs. 5.1+/-2.6 mg/ml, P<0.01), and TBARS (3.3+/-1.0 vs. 3.1+/-0.9 nmol/ml, P<0.05), and @entity23260 decreased LDL @entity165 . After 3 months of therapy, @entity2993 decreased small dense LDL @entity165 (8+/-13%, P<0.0001) additionally, and @entity23260 decreased small, dense LDL @entity165 (51+/-11 vs. 12+/-22%, P<0.0001) and plasminogen activator inhibitor type 1 (68+/-32 vs. 51+/-21 ng/ml, P<0.05). @entity4631 increased significantly in both groups after 2 weeks, although the relative change in @entity4631 was greater with @entity23260 therapy after 2 weeks than @entity2993 therapy (60+/-78 vs. 23+/-26%, P<0.05). However, @entity4631 was the same for both groups after 3 months (58+/-65 vs. 66+/-61%, NS), because @entity2993 additionally increased @entity4631 . There was no correlation between these pleiotropic effects and the improvement in the lipid profile for either group. CONCLUSIONS: These findings suggest that the degree of pleiotropic effect as well as the time course for the effect are different among members of the statin class of drugs.
