XXXX caused by multidrug-resistant bacteria in a French university hospital center: 3  years of collection.

@entity1 @entity3256 @entity2176 @entity5505 @entity796 @entity794 @entity2348 @entity2893 @entity3064 @entity2259
BACKGROUND: The aim of the study was to describe the profile of @entity1 and the characteristics of all @entity2259 caused by multidrug-resistant (MDR) bacterial strains in a teaching hospital and to assess the mortality related to these events. METHODS: A monocentric retrospective observational cohort study was conducted. All @entity1 with @entity2259 caused by MDR bacteria between 2011 and 2013 were included. The characteristics of @entity1 and @entity2259 , antibiotic therapy within the first day, and 30-day mortality were collected from the electronic medical records database. RESULTS: A total of 228 @entity1 were included with @entity2259 caused by Enterobacteriaceae-producing extended-spectrum b-lactamase (n  =  102), Enterobacteriaceae overproducing AmpC b-lactamase (n  =  59), @entity2893 -resistant Enterobacteriaceae (n  =  3), @entity5505 - or @entity2893 -resistant @entity3064 (n  =  2), @entity5505 - or @entity2893 -resistant @entity796 (n  =  23), @entity3256 -resistant @entity794 (n  =  40), and @entity2176 -resistant Enterococcus (n  =  2). The median Charlson comorbidity score was 6. Inappropriate antibiotic therapy was prescribed in 41.7% of @entity2259 , and 30-day mortality was 23%. For 20.9% of the @entity1 who had had a positive bacteriologic sample in the preceding 2  months, the initial antibiotic therapy was inappropriate. CONCLUSION: In this cohort of @entity2259 @entity1 , a high rate of mortality and numerous @entity1 comorbidities were observed. Taking greater account of antecedents of MDR @entity2348 could improve the rate of appropriate initial antibiotic therapy.
