The natural history of small bowel XXXX .

@entity1 @entity417 @entity548 @entity75 @entity2817 @entity1943 @entity340 @entity360 @entity3503
UNASSIGNED: Background Small bowel @entity2817 (SBA) account for 50% of obscure @entity360 . Lesions bleed recurrently and current treatments are relatively ineffective at reducing re- @entity548 . Little is known about the natural history of SBA which is needed to guide treatment decisions and counsel @entity1 on prognosis. Aim The aim of this study is to describe the natural history of a cohort of @entity1 with SBA. Methods @entity1 with SBA were identified retrospectively and clinical and outcome information were collected. Logistic regression analysis was performed to identify factors associated with re- @entity548 . Results SBAs were found in 86 @entity1 of which 54% (n   =   47) were female, and the average age was 71.6 years. The majority (69%) had @entity75 , mean of 2.76/ @entity1 , and 65% were located in the jejunum. Follow-up was available in 65% (n   =   56). There was a significant increase in haemoglobin level from 10.05g/dL to 11.94g/dL, p   <   0.001 after mean follow up of 31.9 (6-62) months. Re- @entity548 events occurred in 80% (n   =   45), with an average of 2.91/ @entity1 . The mean interval between diagnosis and the first re- @entity548 event was 10.7 months. Of the group overall, 70% (n   =   40) required transfusions during follow up, and 67% required hospitalisation due to re- @entity548 . About 50% received a directed treatment, including @entity3503 plasma coagulation, @entity1943 analogues, or surgical resection. A total of 3.5% (n   =   2) died as a direct consequence of @entity548 from SBAs. @entity75 (p   =   0.048) and @entity340 (p   =   0.034) were predictive of re- @entity548 . Conclusion Our results show the significant impact of SBA on @entity1 ' morbidity, with high rates of re- @entity548 , persistent @entity417 and a mortality rate of 3.5%, despite the use of currently available medical and endoscopic therapies.
