Milk transfer of @entity11121 during puerperal XXXX .

@entity1 @entity972 @entity114 @entity1372 @entity1132 @entity25982 @entity11121 @entity1271 @entity413
1 The milk excretion of @entity11121 ( @entity25982 ) was studied from both breasts in @entity1 with @entity1271 (n = 12) and healthy volunteers (controls, n = 4) to investigate the hypothesis that milk transfer of @entity25982 is higher in mastitic than in non-mastitic breasts. 2 @entity1 were included according to clinical symptoms of @entity1271 . Milk (and serum from controls) were sampled 0, 1, 2, 3, 4, 6 and 8 h after a single oral dose of 1320 mg @entity25982 . @entity114 concentrations in milk and serum were measured by an agar diffusion technique. 3 Maximum milk concentrations (Cmax) of @entity25982 in @entity1 were higher (P less than 0.05) in mastitic than in non-mastitic breasts. The latter concentrations were higher (P less than 0.05) than those in breast milk from healthy controls. In milk from the @entity1271 @entity1 (both breasts) the Cmax was reached after 2 h with a subsequent rapid decline in concentration. In milk from the healthy controls the @entity25982 concentration reached a plateau after 4 h. The area under the milk concentration vs time curve (AUC0-8h) was not different for mastitic vs non-mastitic breast milk in @entity1 nor for mastitic vs control breast milk. This can be explained by higher rates of appearance and disappearance of @entity25982 in the breast milk of @entity1271 @entity1 compared with healthy controls. In mastitic breast milk there was a moderate (P less than 0.01) increase in @entity1372 and albumin compared with non-mastitic milk. However, milk @entity972 , @entity413 and @entity1132 values were within normal limits.(ABSTRACT TRUNCATED AT 250 WORDS)
