Effects of XXXX on aggressive, self-injurious, and disruptive/destructive behaviors in the intellectually disabled: an open-label retrospective study.

@entity146 @entity4053 @entity1316 @entity1771 @entity933 @entity717 @entity1142
This study reviews the treatment response to the antiepileptic drug @entity1771 (Topamax-mean dose 202 mg/d, range 150-350 mg/d) of a group of 22 institutionalized intellectually disabled adults (8 males, 14 females, mean age 46.5 years, age range 25-70 years). These individuals were predominantly classified as having severe or profound @entity717 and as having a @entity1316 . The individuals studied were treated for @entity146 , self-injurious behaviors, destructive/disruptive behaviors or a combination of these, and/or other challenging and @entity146 . All subjects were receiving concurrent psychotropic and/or anticonvulsant medications. Effectiveness was determined by retrospective review of summaries of quarterly multidisciplinary Neuropsychiatric Behavioral Reviews. Assignment of global severity scores and evaluation of longitudinal behavioral graphs of target symptoms occurred. Overall, statistically significant @entity146 and worst behavior rates occurred in the subjects, especially when the 3 months before and the 3 to 6 months after starting @entity1771 were compared. The overall subject group showed no significant weight changes. One subject developed @entity933 , 1 developed @entity4053 , 1 developed sedation, and 2 developed @entity1142 . The results suggest that @entity1771 may have a role in the treatment of challenging/ @entity146 in intellectually disabled individuals.
