The cardiovascular effects of @entity5161 in XXXX .

@entity5161 @entity26 @entity64 @entity742
The effects of 1.0 and 1.5 minimum alveolar concentrations (MAC) of @entity5161 on mean systemic arterial pressure, heart rate, @entity64 volume, cardiac output, total body @entity26 consumption, myocardial @entity26 consumption, and regional distribution of blood flow were studied in newborn @entity742 . Fractional extraction of @entity26 for the total body and for the myocardium were calculated. MAC for @entity5161 was first determined in eight @entity742 less than 10 days old. The mean value obtained was 1.51%. Six different @entity742 were used for cardiovascular study. Heart rate, @entity64 volume, cardiac output, and mean systemic arterial pressure decreased significantly during @entity5161 anesthesia. Mean systemic arterial pressure and cardiac output decreased in a dose-dependent manner. Heart rate decreased significantly at 1.0 MAC @entity5161 , but no further at 1.5 MAC. @entity64 volume decreased only at 1.5 MAC. Cardiac output and total body @entity26 consumption decreased by similar amounts at 1.0 MAC. Although cardiac output fell further at 1.5 MAC, @entity26 consumption did not. Fractional extraction of @entity26 increased only at 1.5 MAC. Myocardial blood flow and @entity26 consumption decreased in parallel at 1.0 MAC, with no significant change during 1.5 MAC. Myocardial fractional @entity26 extraction did not change. Although blood flow to all six body regions decreased significantly from control at both concentrations of @entity5161 , blood flow to all organs except the adrenal did not differ significantly during 1.0 and 1.5 MAC. The authors conclude that a decrease in @entity26 requirement during @entity5161 anesthesia results in an appropriate decrease in @entity26 delivery, with no apparent diversion of cardiac output from non-vital to vital organs.(ABSTRACT TRUNCATED AT 250 WORDS)
