Possible involvement of b    receptors in various emetogen-induced increases in salivary amylase activity in XXXX .

@entity1169 @entity13557 @entity35 @entity935 @entity900 @entity391 @entity3826 @entity10442 @entity1769 @entity24971 @entity3044 @entity2165 @entity4113
We investigated the inhibitory effects of b   - or b   -adrenoceptor (AR) antagonists on salivary amylase secretion produced by various emetic agents, such as @entity900 , @entity3826 , and @entity13557 ( @entity4113 ), or the non-emetic agent b(  )-AR agonist @entity3044 in @entity35 . We also determined the inhibitory effect of @entity1769 , a @entity935 D   -receptor antagonist, on increases in the salivary amylase activity induced by @entity3826 or @entity10442 , a 5-HT(3)-receptor antagonist, on @entity4113 -induced increased salivary amylase activity. @entity3044 (0.01 mg/kg, s.c.) produced an increase in salivary amylase and the increase was inhibited by the b(  )-AR antagonist @entity1169 (5 mg/kg, s.c.) and b   -AR antagonist @entity2165 (2 mg/kg, s.c.) but not by the b   -AR antagonist @entity24971 (8 mg/kg, s.c.). The increased amylase activity induced by @entity900 (15 mg/kg, i.v.), @entity3826 (3 mg/kg, s.c.), or @entity4113 (120 mg/kg, i.p.) was inhibited significantly by @entity2165 (2 mg/kg, s.c.) but not by @entity24971 (8 mg/kg, s.c.). In addition, increases in amylase activities induced by @entity3826 and @entity4113 were inhibited significantly by @entity1769 (10 mg/kg, i.v.) and @entity10442 (3 mg/kg, i.v.), respectively. These results suggest that salivary amylase secretion induced by various emetogens is involved in b   -adrenoceptor activity and that salivary amylase activity is useful to detect emetogens with no direct b   -AR activation in @entity35 , a species that does not exhibit @entity391 .
