XXXX and atypia in biopsies performed for nonpalpable lesions detected mammographically.

@entity1 @entity0 @entity66 @entity5 @entity1373 @entity189 @entity1558
A recent study of risk factors for @entity0 indicated elevated risks of 5.3 and 1.9 times, respectively, for @entity1 with biopsy specimens showing @entity1373 ( @entity1373 ) and @entity66 without atypia. These risks increase to 11 and 3.2 times, respectively, in @entity1 who also have a family history of @entity0 . This study reviews lesions detected mammographically in a series of @entity1 with documented risk factors. The pathologic specimens of 100 consecutive localization breast biopsies performed for nonpalpable abnormalities detected mammographically were reviewed and classified according to the criteria of Dupont and Page in order to determine the incidence of @entity1373 and @entity1558 . The mammographic characteristics and historical risk factors of these @entity1 also were correlated. Twenty percent of the biopsy specimens showed @entity189 , 55% of which were noninvasive. @entity1373 was found in an additional 10% of the biopsy specimens, whereas @entity66 without atypia occurred in 21% of the biopsy specimens. Forty-nine percent of the biopsy specimens showed nonproliferative changes. This study demonstrated that mammography, in addition to its ability to detect small nonpalpable @entity5 , identifies a high percentage (31% in this series) of @entity1 with pathologic lesions known to have an elevated risk for subsequent @entity0 . The current impetus for large-scale mammographic screening of asymptomatic @entity1 mandates the development of rational therapeutic protocols to accommodate the widening spectrum of high-risk pathologic lesions found in these selected populations.
