Radionuclide therapy for XXXX .

@entity1 @entity157 @entity82 @entity2857
AIM: Several techniques for radionuclide therapy of @entity157 ( @entity157 ) have been developed. In this overview the available radionuclide treatment modalities for @entity157 are presented, with an emphasis on Yttrium-90 (90Y) microspheres. METHODS: We comment on the commercially available products and describe the practical aspects of these treatment modalities. Medical literature was screened for clinical data on these therapies in @entity1 suffering from @entity157 . The most relevant studies are summarized, focusing on @entity1 selection, safety and outcome. DISCUSSION: Randomized trials are still ongoing or recently initialized. These trials will elucidate the role of 90Y-microspheres in relation to biotherapy and chemoembolization for palliative use in @entity1 not amenable to surgery. CONCLUSION: Large retrospective or cohort studies proof the safety of 90Y-microspheres for palliative use in @entity157 @entity1 suffering @entity1 -Pugh A or B7 @entity82 . Future research will yield more information on its efficacy when compared to chemoembolization or @entity2857 . Several groups have reported on the use of selective internal radiation therapy (SIRT) for downstaging @entity1 to surgical curative treatment.
