Doppler-based renal XXXX for prediction of renal dysfunction reversibility: A systematic review and meta-analysis.

@entity810 @entity1 @entity3013
BACKGROUND AND OBJECTIVES: Doppler-based renal @entity3013 ( @entity3013 ) might help in distinguishing transient from persistent @entity810 ( @entity810 ). The main objective of these systematic review and meta-analysis was to investigate the diagnostic performance of @entity3013 in predicting short-term reversibility of @entity810 . STUDY DESIGN: A systematic review of the literature was performed. Relevant studies were identified in Pubmed and Cochrane databases covering the years 1985 to 2013 and reviewed independently by 3 authors. Renal transplant recipients were excluded from this analysis. The summary estimates were computed using a random-effects model based on the DerSimonian and Lair meta-analytic method. RESULTS: Among the 154 unique articles identified, 9 studies were included. Of the 176 @entity1 in these studies with elevated @entity3013 or pulsatility index, 146 (83%) had a persistent @entity810 vs 44 (16%) of the 273 @entity1 with normal values. Elevated @entity3013 or pulsatility index was associated with an increased risk of persistent @entity810 (odds ratio, 29.85; 95% confidence interval [CI], 8.73-102.16; P < .00001) with significant heterogeneity (I(2) = 75.0%, P < .0001). The pooled sensitivity and specificity were 0.83 (95% CI, 0.77-0.88) and 0.84 (95% CI, 0.79-0.88). The summary positive and negative likelihood ratios were 4.9 (95% CI, 2.44-9.87) and 0.21 (95% CI, 0.11-0.41). CONCLUSION: These results suggest that an elevated @entity3013 may be a predictor of persistent @entity810 in critically ill @entity1 . Further studies are warranted, however, to clarify the exact test performance given the marked heterogeneity among the included studies.
