Improvement Characteristics of Bio-active Materials Coated Fabric on XXXX Muscular Mitochondria.

@entity1976 @entity32279 @entity2310 @entity26 @entity6229 @entity2311 @entity47128 @entity35 @entity4124
This study surveys the improvement characteristics in old-aged muscular mitochondria by bio-active materials coated fabric (BMCF). To observe the effects, the fabric (10 and 30%) was worn to old-aged @entity35 then the @entity26 consumption efficiency and copy numbers of mitochondria, and mRNA expression of apoptosis- and mitophagy-related genes were verified. By wearing the BMCF, the oxidative respiration significantly increased when using the 30% materials coated fabric. The mitochondrial DNA copy number significantly decreased and subsequently recovered in a dose-dependent manner. The respiratory control ratio to mitochondrial DNA copy number showed a dose-dependent increment. As times passed, @entity2310 , @entity2311 , @entity6229 and b-actin increased, and @entity1976 decreased in a dose-dependent manner. However, the BMCF can be seen to have had no effect on @entity32279 . @entity47128 expression did not change considerably and was inclined to decrease in control group, but the expression was down-regulated then subsequently increased with the use of the BMCF in a dose-dependent manner. @entity4124 increased and subsequently decreased in a dose-dependent manner. These results suggest that the BMCF invigorates mitophagy and improves mitochondrial oxidative respiration in skeletal muscle, and in early stage of apoptosis induced by the BMCF is not related to extrinsic death-receptor mediated but mitochondria-mediated signaling pathway.
