@entity20319 polymorphisms associated with survival among Chinese @entity150 @entity1 receiving XXXX and @entity1138 .

@entity1 @entity1138 @entity1259 @entity20319 @entity71887 @entity1139 @entity150 @entity71886 @entity71885
UNASSIGNED: The association between DNA repair gene polymorphisms and @entity150 risk has been widely studied. However, only few studies have examined the correlation between @entity150 and instillation agent sensitivity. The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I ( @entity20319 ) @entity71885 and @entity71886 , and @entity150 recurrence risk. We recruited 244 @entity1 (130 treated with @entity1259 and 114 treated with @entity1138 ). Genomic DNA was used to examine the @entity20319 @entity71885 and @entity71886 genotypes by Taqman PCR analysis. Combination analysis of @entity20319 @entity71885 and @entity71886 and examination of @entity20319 diplotypes were performed to reveal possible correlations. The @entity71885 CC and @entity71886 TT genotypes conferred shorter survival times than the @entity71885 @entity71887 and @entity71886 CC/CT genotypes in @entity1 treated with @entity1259 , but not in those treated with @entity1138 ( @entity1139 ) in adjusted models [hazard ratio (HR)   =   0.23, 95  % confidence interval (CI)   =   0.10-0.53 for @entity71885 AC   +   AA compared with CC; HR   =   0.17, 95  % CI   =   0.06-0.46 for @entity71886 CC   +   CT compared with TT]. Combination analysis showed significantly increased recurrence-free survival (RFS) among @entity1 simultaneously carrying the @entity71885 @entity71887 and @entity71886 CC/CT genotypes with an HR of 0.15 (95  % CI   =   0.05-0.45) compared to those carrying other genotypes. Diplotype analysis demonstrated that the A-C/C-T diplotype is associated with a lower risk of recurrence compared with the common wild C-T/C-T diplotype (HR   =   0.17, 95  % CI   =   0.06-0.51). Our results suggest that the @entity71885 CC and @entity71886 TT genotypes confer higher sensitivity to @entity1259 instillation. Moreover, the A-C/C-T diplotype presents significantly lower recurrence risk than other diplotypes.
