[Prevention of XXXX before @entity63 by pharmcologic donor conditioning--experimental findings].

@entity1707 @entity63 @entity26 @entity1011 @entity17295
The loop-diuretic @entity17295 was used to study the influence of pharmacological donor pretreatment on immediate postischemic function in a @entity1707 model of kidney transplantation based on the results of a clinical pilot study [4]. Following laparotomy, both kidneys were flushed via a transaortal catheter with Eurocollins-solution and surgically removed. A cold ischemic period of 1 or 24 h was chosen. After that period, kidneys were reperfused with intraoperatively drawn heparinized blood for one hour. We used a special instrument for hemoperfusion of isolated organs which allows perfusion for several hours under steady-state conditions. Four groups were formed: Control and @entity17295 , 1 or 24 h @entity63 . The perfusion of @entity17295 -treated organs resulted in a lower perfusion-resistance, calculated as pressure/flow-ratio or as pressure/glomerular filtrationratio. The flow in the pretreated group was higher, thus excluding a higher shunt-volume. In parallel, @entity26 consumption as a parameter of postischemic function start and @entity1011 clearance were higher in the @entity17295 treated groups. The experiments demonstrate a superior postischemic function of pretreated kidneys in comparison to control organs after 1 and 24 hours of @entity63 in this model.
