[The importance of @entity3422 in differential diagnosis of XXXX ].

@entity1 @entity1204 @entity5 @entity3422 @entity4348
OBJECTIVE: The aim of the present study was to evaluate the use of @entity1 epididymis protein 4 ( @entity3422 ) and @entity5 antigen 125 (CA 125) biomarkers in differential diagnosis of @entity5 in a population of Czech @entity1 . DESIGN: Prospective study. SETTING: Department of Gynaecology and Obstetrics, Faculty of Medicine at Masaryk University and Faculty Hospital in Brno. METHODS: Our prospective study includes 115 @entity1 with @entity4348 and 106 @entity1 with @entity5 in the control group. They were diagnosed with endometrial biopsy in the period from 7/2010 to 6/2013. The @entity1 with @entity5 underwent definitive surgical treatment to determine the stage of disease. The median and ranges of serum levels were determined in relation to the histological result (benign vs @entity5 ). Statistical analysis operates with logarithm values of markers because their distribution is not normal and uses logistic regression. RESULTS: While analysing two groups of @entity1 with different histology, there was demonstrated a statistically significant difference (p < 0.05), only in @entity3422 , by cut-off 48,5 pmol/l there was achieved sensitivity of 87.8%, specificity of 56.6% and negative predictive value of 81.1%.Coclusion: Diagnostic benefit of @entity3422 can be considered especially in @entity1 with increased risk of @entity1204 and in @entity1 with serious internal co-morbidities. @entity3422 could help in combination with clinical and ultrasound finding in the differentiation of prognostically various groups of @entity1 and in decision-making in relation to the individualization of the treatment plan. However, the optimal cut-off for @entity3422 has not been solved yet, and to do so, it will require more research with larger studies and their comparative analysis..
