IgE responses in XXXX fed moderate protein deficient and high protein diets.

@entity8236 @entity7493 @entity13923 @entity851 @entity19 @entity566 @entity5168 @entity60 @entity1961 @entity58 @entity3147
While severe @entity7493 ( @entity7493 ) has been known to depress several immune functions, @entity566 are suppressed by decreasing IgE and impairing vascular permeability and mast cell functions. To address the effect of moderate @entity3147 without @entity851 and protein hypernutrition on type I @entity566 , we examined the effect of various levels of protein nutrition on @entity566 at humoral immunity and the regulation of Th cell function levels. @entity19 fed 100 g/kg (moderate @entity3147 ; MPM), 200 g/kg (normal protein nutrition; PN) and 400 g/kg (protein hypernutrition; PH) protein diets were intraperitoneally sensitized to ovalbumin (OVA) in @entity13923 . Higher elevations of OVA-specific IgE and total IgE in the serum were observed in the PH group as compared to the PN group. However, OVA-specific IgE in the MPM group was not significantly different from that in the PN group, although the former appeared higher than the latter. While @entity5168 , @entity1961 , CD8 and @entity8236 expressions in the splenic lymphocytes were decreased in the MPM group, @entity8236 expressions were increased in the PH group. Splenic lymphocyte proliferative responses to OVA were augmented in the PH group and depressed in the MPM group. @entity60 production from splenic lymphocytes was significantly decreased; however, @entity58 production was not affected significantly in the MPM group, and increased in the PH group. These findings suggest that immune functions to specific antigens in the MPM state are depressed at the cytokine level but not in terms of IgE responses. They also suggest that immune functions become Th2-predominant in the PH state, resulting in an increased risk of type I @entity566 .
