On the oncodevelopmental role of XXXX imprinted genes.

@entity1 @entity43 @entity980 @entity478 @entity5 @entity9037 @entity1469 @entity5100 @entity160 @entity3969 @entity8498
Genome imprinting has an essential role in normal embryonal @entity1 development. Starting early in differentiation, the transcripts of certain @entity1 genes, e.g. the paternally- @entity9037 and the maternally-imprinted @entity5100 , are expressed in specific tissues and organs during fetal life. In several @entity5 , imprinted genes are, again, unfolded. Characteristically, expression follows the same tissue presentation as during embryogenesis. Clinical paternal disomies, i.e. @entity1469 , and their maternal counterpart, i.e. @entity43 , are associated with apparent relaxation of imprinting once they turn malignant. Paediatric @entity5 , like @entity3969 ( @entity3969 ) and @entity980 , often express @entity5100 and @entity9037 . Recently, we have found @entity9037 expression in invasive @entity5 . Evidently, imprinted genes display an oncodevelopmental mode of expression, very much like the classical oncofetal proteins @entity160 and @entity478 . Based on available data, including @entity5 preferential paternal allele retention and chromosome 11 short arm physical linkage with oncogenes like @entity8498 , we hypothesize that imprinted genes not only accompany @entity5 but may play a causative role as well.
