Relationships between serum adipokines, @entity2690 levels, and bone density in XXXX with @entity1278 .

@entity1 @entity442 @entity2690 @entity1278 @entity1942 @entity53 @entity79 @entity1254 @entity701 @entity413
BACKGROUND: Adolescents with @entity1278 ( @entity1278 ) have low @entity79 ( @entity79 ). Adipokines and @entity2690 play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in @entity1278 is unknown. OBJECTIVE: The aim of the study was to determine whether adipokines and @entity2690 are independently associated with measures of @entity79 in adolescents with @entity1278 and controls. DESIGN/METHODS: Levels of @entity1254 and @entity2690 , fasting and after oral @entity413 , were evaluated in 17 @entity1278 @entity1 and 19 controls (age, 12-18 yr), in whom hormonal parameters [GH, @entity442 , @entity701 , @entity53 , leptin, ghrelin, and @entity1942 ( @entity1942 )] had been previously determined. Body composition, bone mineral content, and @entity79 at the lumbar spine, hip, femoral neck, and total body were assessed by dual energy x-ray absorptiometry. Two bone formation and bone resorption markers were examined. SETTING: The study was conducted at a General Clinical Research Center. RESULTS: @entity1254 differed between @entity1278 subjects and controls after controlling for fat mass and decreased in both after oral @entity413 (P = 0.02 and 0.07). On regression modeling, independent associations were observed of: 1) body mass index and @entity1254 with lumbar spine bone mineral apparent density Z-scores (r(2) = 0.45); 2) lean mass, @entity1942 , and ghrelin with hip Z-scores (r(2) = 0.55); 3) @entity1254 and lean mass with femoral neck-bone mineral apparent density Z-scores (r(2) = 0.34); and 4) lean mass, @entity1942 , GH, and ghrelin with total body-bone mineral content/height Z-scores (r(2) = 0.64), for the combined group. @entity1254 was also independently associated with @entity79 , and @entity2690 was associated with bone turnover markers in the groups considered separately. CONCLUSIONS: @entity1254 contributes significantly to the variability of bone density, and @entity2690 contributes to bone turnover markers in adolescent @entity1 .
