The early changes in experimental myopathy induced by XXXX and @entity8970 .

@entity39 @entity3986 @entity1159 @entity35 @entity8970 @entity503 @entity528
In soleus muscles of @entity35 treated for 2 to 11 days with high doses of @entity503 or @entity8970 , muscle fibres showed autophagocytosis followed by segmental @entity1159 and @entity39 . @entity528 , "splitting", and internal nuclei were absent. At variance with findings in progressive @entity3986 , the incidence of intramembrane particles was unchanged and membrane defects in @entity39 fibres were absent. Autophagic vacuoles were formed by cup-shaped cisternae derived from tubules that often enclosed single mitochondria. Golgi complexes occurred in the centre of the fibres; dilated vesicles of the sarcoplasmic reticulum contained an electrondense substance, possibly lysosomal enzymes. Exocytosis of autophagic vacuoles and of almost undigested mitochondria was observed. The changes in the plasma membrane were as in other cells: a bulge was formed that was cleared of intramembrane particles; the membrane fused with the limiting membrane of the autophagic vacuole, the content of which was expelled through an orifice. Inside autophagic vacuoles, persisting phospholipids arranged themselves into protein-free lipid bilayers, that formed concentric membranes or single-layered vesicles. Both drugs are known to inhibit degradation of phospholipids; the findings indicate that the rate of autophagocytosis and exocytosis were enhanced as well. Fibre @entity39 was probably due to the fact that fibres eventually became unable to maintain their integrity.
