XXXX virulence patterns may help to predict @entity3025 in paediatric urinary tract infections.

@entity1 @entity3025 @entity2885 @entity2335 @entity526
AIM: Ultrasound and biological tools are used to predict high-grade @entity3025 , but other markers are needed to better select @entity1 who need voiding cystography. Our aim was to determine whether studying @entity526 virulence factors would help to predict @entity3025 in @entity1 with their first acute @entity2885 . METHODS: We included @entity1 presenting with @entity526 -related acute @entity2885 or @entity2335 . Vesicoureteral reflux was assessed by voiding cystography. Virulence factors were identified by multiplex polymerase chain reaction. Statistical analysis was performed using logistic regression and the mean c-statistic test. RESULTS: We included 198 @entity1 : 30 with @entity2335 and 168 with acute @entity2885 , including 46 with @entity3025 . High-grade reflux was associated with acute @entity2885 caused by the @entity526 lacking virulence factors papGII (82% versus 47%, p  <  0.001) or papC (85% versus 53%, p  <  0.001) or belonging to phylogenetic group A or B1. When we added genetic data (lack of papGII, fyuA and phylogenetic groups) to classical predictors of @entity3025 (ultrasound examination, gender, age), the ability to predict high-grade reflux increased, with the c-statistic rising from 0.88 to 0.93. CONCLUSION: Bacterial virulence factors and clinical factors helped to predict high-grade reflux and may help to avoid unnecessary voiding cystographies.
