Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from @entity1 with XXXX .

@entity1 @entity32 @entity10431 @entity1333 @entity4105 @entity2071 @entity4725 @entity715 @entity15
Activation of the vascular endothelium is thought to be an important facet of @entity32 , @entity715 , and @entity1333 . Activated endothelial cells express a number of immunologically relevant surface markers not expressed by normal endothelial cells. Many of these surface antigens are thought to augment adhesion reactions and migration. Our results show that endothelial activation may play a central role in the pathogenesis of @entity15 ( @entity15 ). Normal @entity1 central nervous system microvessels isolated from autopsy material do not express endothelial cell activation markers, including the adhesion proteins @entity4725 ( @entity4725 ) and endothelial cell leukocyte adhesion molecule-1 ( @entity4105 / @entity4105 ). They exhibit little to no constitutive expression of immunoreactive @entity2071 ( @entity2071 ) or the @entity10431 . Control microvessels exhibit no major histocompatibility complex (MHC) class II antigen. @entity15 microvessels express significant levels of MHC class II antigens, @entity2071 , @entity4725 , and @entity10431 . @entity4105 was expressed by 3 of 5 @entity15 brains tested. Histologically unaffected areas of @entity15 brain expressed less @entity4725 , @entity2071 , and @entity4105 than did microvessels from periplaque zones. However, MHC class II antigens and @entity10431 were increased in areas exhibiting little to no evidence of leukocyte infiltration. When microvessels were examined for dual expression of activation markers, we found that in periplaque areas, 50% of microvessels coexpressed HLA-DR and @entity4725 , 28% of microvessels coexpressed HLA-DR and @entity10431 , and 43% of microvessels coexpressed HLA-DR and @entity2071 .
