Dietary approaches to stop XXXX influence on @entity8277 substrate-1gene expression: A randomized controlled clinical trial.

@entity1 @entity10175 @entity101 @entity1372 @entity8277 @entity65 @entity165
BACKGROUND: @entity8277 substrate (IRS) Type 1 is a main substrate for the @entity8277 , controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approaches to Stop @entity101 (DASH) and Usual Dietary Advices (UDA) on @entity10175 gene expression in @entity1 at risk for @entity65 . MATERIALS AND METHODS: A randomized controlled clinical trial was performed in 44 @entity1 at risk for @entity65 . @entity1 were randomly assigned to a UDA diet or the DASH diet. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, @entity165 , refined grains, and sweets, with a total of 2400 mg/day @entity1372 . The UDA diet was a regular diet with healthy dietary advice. Gene expression was assessed by the real-time polymerase chain reaction at the first of study and after 12 weeks. Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively. RESULTS: @entity10175 gene expression was increased in DASH group compared with UDA diet (P = 0.00). Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference. CONCLUSION: DASH diet increased @entity10175 gene expression and probably has beneficial effects on IR risks.
