Regulatory XXXX and @entity4965 intoxication: A possible explanation of the case of "A Civil Action".

@entity1 @entity2214 @entity417 @entity19360 @entity5 @entity7101 @entity42654 @entity1778 @entity4965 @entity1446
In 1998, a amovie entitled "A Civil Action" was released. The movie described the Woburn case, begun in 1982 and concluded in 1990, one of the most famous cases of @entity4965 pollution. In a small town near Boston, twelve @entity1 died of @entity1778 , which seemed attributable to @entity4965 contamination of the drinking water. The victims, however, could not win the case, since evidence that the identified chemicals could cause @entity1778 and other @entity1 illnesses was rather sketchy. There have been many cases of @entity4965 pollution in industrial nations including Japan, therefore, we reconsidered the missing link. Our conclusion is that the disease occurred not by a direct effect of the chemical hazard on biological macromolecules but by an indirect effect through the physiological system such as signal transduction and transcriptional regulation. In 1984, we reported a marked reduction in the regulatory @entity1446 pool by @entity4965 exposure, however, the biological significance was not well understood. Recently, we found that the DNA binding activity of @entity7101 , a negative regulator of genes, is controlled by @entity1446 , the regulation of which seems to explain how @entity1778 develops. The heterodimer of @entity7101 with @entity42654 recognizes Maf recognition elements (MAREs) competing with the erythroid type positive regulator, a complex of @entity19360 with @entity42654 . @entity7101 / @entity42654 occupies MAREs under lower @entity1446 conditions, whereas MAREs are open to @entity19360 / @entity42654 along with increasing @entity1446 concentration. Since the @entity19360 / @entity42654 function is closely related to normal erythroid differentiation, of which disorders such as sideroblastic @entity417 are often related to @entity5 ; i.e., a @entity2214 that can progress to @entity1778 . Thus, a marked decline in regulatory @entity1446 by @entity4965 intoxication could be one of the pathways to @entity1778 .
