Utility of XXXX Capsid Protein L1 and @entity986 in the Assessment and Accurate Classification of Anal Squamous Intraepithelial Lesions.

@entity32 @entity6205 @entity986 @entity5 @entity1082 @entity24103 @entity2784
OBJECTIVES: Morphologic evaluation of @entity24103 remains problematic, especially in cases with limited biopsy samples or obscuring @entity32 . Studies in cervical @entity5 have shown that @entity1082 ) L1 capsid production is highest in low-grade @entity2784 (LSILs) and progressively decreases in high-grade @entity2784 (HSILs). The combined utility of HPV L1 and @entity986 expression in assessing anal @entity2784 ( @entity2784 ) has never been analyzed and forms the basis of this study. METHODS: In total, 145 anal lesions were reviewed and immunohistochemically stained for HPV L1 and @entity986 . @entity986 expression was recorded as negative, patchy/focal, or diffuse. For analytical purposes, @entity6205 were evaluated separately from rest of the LSILs. RESULTS: There were 34 (23%) @entity6205 , 64 (44%) LSILs, and 47 (32%) HSILs. HPV L1 was significantly associated with @entity6205 (68%) and LSILs (52%) compared with HSILs (9%; P < .0001). Diffuse @entity986 staining was present only in HSILs (P < .0001), whereas a patchy/focal @entity986 staining pattern was observed in both LSILs and @entity6205 . CONCLUSIONS: HPV L1 and diffuse @entity986 expression is mutually exclusive in most anal @entity2784 and helps separate @entity2784 and @entity2784 cases. Application of both HPV L1 and @entity986 can not only facilitate accurate grading but also contribute to risk assessment in anal @entity5 .
