The impact of the introduction of @entity348 on local recurrence rate and survival in XXXX : long-term results.

@entity1 @entity5 @entity262 @entity348 @entity3 @entity204
PURPOSE: To investigate the influence of the introduction of @entity348 ( @entity348 ) on local recurrence rate and survival in @entity1 with @entity5 . METHODS: A total of 171 consecutive @entity1 underwent anterior or abdominoperineal resection for primary @entity5 . When the @entity348 technique was introduced, the clinical setting, including the surgeons, remained the same. Group 1 (1993-95, n =53) underwent conventional surgery and group 2 (1995-2001, n = 118) underwent @entity348 . All @entity1 were followed for 7 years or until @entity204 . RESULTS: Between the two groups, no statistically significant differences were present with regards to @entity1 -, treatment-, or @entity5 -related characteristics apart from the time point of radiotherapy. The total local recurrence rates were 11 of 53 (20.8%) in group 1 and 7 of 118 (5.9%) in group 2, and the rates of isolated local recurrences were 6 of 53 (11.3%) in group 1 and 2 of 118 (1.7%) in group 2. Both differences were highly statistically significant. The disease-free survival in groups 1 and 2 was 60.4 and 65.3% at 5 years, and 58.5 and 65.3% at 7 years, respectively. Excluding @entity1 with synchronous or metachronous distant @entity3 from the analysis, both the @entity5 -specific survival were statistically significantly better in group 2 than in group 1. No statistically significant difference between the two groups was detected regarding the overall survival. CONCLUSIONS: The introduction of @entity348 led to an impressive reduction of the local recurrence rate. Survival is mainly determined by the occurrence of distant @entity3 , but @entity348 seems to improve survival in @entity1 without @entity262 .
