Sympathoadrenal mechanisms in cardiovascular responses to @entity1510 after XXXX .

@entity2997 @entity548 @entity1425 @entity95 @entity1510 @entity1063
Five @entity95 were allotted to each of six treatments on a matched-individual basis. Treatments were none, sham, total adrenalectomy with adrenocorticoid replacement, intravenous @entity2997 (15 mg X kg-1 X day-1), adrenalectomy + @entity2997 , and adrenal medullectomy. The conscious @entity95 were bled 20 ml/kg over 5 min. @entity1510 (6 mg/kg) was injected intravenously. The responses of arterial pressure and of plasma @entity1425 (E) and @entity1063 (NE) concentrations were measured. Factorial analysis was used to calculate the effects of sympathetic noradrenergic nerves (SYM) and the adrenal medulla (ADR) on the responses. In combination, SYM + ADR fully accounted for the pressor response observed in normal and sham-treated @entity95 . SYM and ADR each made independent and approximately equal contributions to the response, but the SYM X ADR interaction was strongly antagonistic. The responses of plasma E and NE were fully accounted for by the adrenal glands and sympathetic nerves, respectively. The pressor responses after total adrenalectomy and adrenal medullectomy were similar. Thus @entity548 -stimulated adrenal corticosteroid release was not essential to @entity1510 's action, and adrenal enkephalins were not responsible for @entity1510 's action on sympathetic pathways.
