Linear accelerator radiosurgery for XXXX : Results of medium-term follow-up.

@entity5 @entity1 @entity5513 @entity2103
BACKGROUND: To examine @entity5 control, via volume changes, and the complications of linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) treatment of @entity5513 ( @entity5513 ) on medium-term follow-up. METHODS: Between September 2003 and November 2009 fifty consecutive @entity1 with @entity5513 treated with SRS using a marginal dose of 12.5 Gy utilizing a LINAC equipped with a micro-multileaf collimator were identified. Evaluation included serial magnetic resonance imaging (MRI), and neurological and hearing examinations. RESULTS: The median @entity5 volume at treatment was 2.4 (range: 0.24-10.59) cm(3). The intracranial diameter of the @entity5 ranged between 7.7 and 28.7 (median: 15.8) mm. Follow-up MRI was available for analysis on 49 @entity1 . The median radiological follow-up period was 5.8 (range: 1.4-9.2) years. The median @entity5 volume at last follow-up was 1.1 (range: 0.03-5.3) cm(3). VS decreased in size in 45 (90%) @entity1 , with a median reduction in @entity5 volume of 1.46 (range: 0.06-9.29) cm(3) or a median @entity5 size reduction of 59% of the baseline (range: 6-90%) in these @entity1 . VS remained stable in 2 @entity1 and increased in size in 2 @entity1 . Only 1 @entity1 (2%) required additional intervention (surgery). 15 @entity1 had useful hearing pre-treatment; 10 post-treatment pure-tone audiograms of these @entity1 were available. 5 (50%) @entity1 still had useful hearing post treatment. Non-auditory adverse radiation effects included new (House-Brackmann grade II) or worsened @entity2103 (House-Brackmann grade II to grade V) in 2 (4%) @entity1 and trigeminal sensory disturbance in 2 (4%) @entity1 . CONCLUSIONS: At medium term, the vast majority of @entity5513 treated with LINAC-based SRS exhibit @entity5 shrinkage. The slightly higher rate of @entity2103 compared with Gamma Knife surgery (GKS) results may be related to the learning curve. Other complications were similar to reported GKS results for @entity5513 of comparable sizes.
