Increased levels of cerebrospinal fluid XXXX associated with amyloid pathology: links to @entity73 .

@entity1 @entity35368 @entity73 @entity16 @entity195 @entity4675 @entity563 @entity1889 @entity528
BACKGROUND: @entity195 is characterized by @entity73 , senile plaques of b-amyloid (Ab) peptides, neurofibrillary tangles composed of hyperphosphorylated    proteins and @entity528 . Ab and    are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are @entity563 - @entity1889 protein kinases activated by phosphorylation and involved in @entity528 . METHODS: In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Ab,    and @entity4675 isoforms in postmortem brain tissue samples (10 @entity195 and 10 control) and in CSF samples from 30 living @entity1 with @entity195 and 27 controls with @entity16 excluding @entity195 . @entity1 with @entity195 were followed for 1-3 years and assessed using Mini-Mental State Examination scores. RESULTS: The biochemical and morphological results showed a significant increase of @entity35368 and phosphorylated @entity4675 levels in @entity1 with @entity195 , and @entity35368 levels correlated with Ab42 levels. Confocal microscopy revealed that @entity35368 was associated with Ab in senile plaques. The @entity35368 levels in the CSF were significantly elevated in @entity1 with @entity195 and correlated statistically with the rate of @entity73 in a mixed linear model. LIMITATIONS: The study involved different samples grouped into 3 small cohorts. Evaluation of @entity35368 in CSF was possible only with immunoblot analysis. CONCLUSION: We found that @entity35368 levels are increased in brain tissue and CSF from @entity1 with @entity195 . The finding that increased @entity35368 levels in CSF could reflect the rate of @entity73 is new and merits further investigation.
