Medically Unexplained and Explained Physical Symptoms in the General Population: Association with Prevalent and Incident XXXX .

@entity146 @entity1109 @entity1316 @entity148 @entity734
BACKGROUND: Clinical studies have shown that @entity1109 ( @entity1109 ) are related to common @entity146 . It is unknown how often common @entity146 occur in subjects who have explained physical symptoms (PHY), @entity1109 or both, in the general population, what the incidence rates are, and whether there is a difference between PHY and @entity1109 in this respect. AIM: To study the prevalence and incidence rates of mood, @entity148 and substance use disorders in groups with PHY, @entity1109 and combined @entity1109 and PHY compared to a no-symptoms reference group in the general population. METHOD: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face survey of the general population aged 18-64 years. We selected subjects with explained physical symptoms only (n=1952), with @entity1109 only (n=177), with both @entity1109 and PHY (n=209), and a reference group with no physical symptoms (n=4168). The assessment of common @entity146 was through the Composite International Diagnostic Interview 3.0. Multivariate logistic regression analyses were used to examine the association between group membership and the prevalence and first-incidence rates of comorbid @entity146 , adjusted for socio-demographic characteristics. RESULTS: @entity1109 were associated with the highest prevalence rates of mood and @entity148 , and combined @entity1109 and PHY with the highest prevalence rates of @entity734 . Combined @entity1109 and PHY were associated with a higher incidence rate of @entity1316 only (OR 2.9 (95%CI:1.27,6.74)). CONCLUSION: In the general population, PHY, @entity1109 and the combination of both are related to mood and @entity148 , but odds are highest for combined @entity1109 and PHY in relation to substance use disorder. Combined @entity1109 and PHY are related to a greater incidence of @entity1316 . These findings warrant further research into possibilities to improve recognition and early intervention in subjects with combined @entity1109 and PHY.
