XXXX of diffuse type: MR imaging findings and clinical manifestations.

@entity1 @entity5 @entity160 @entity157 @entity99 @entity715
PURPOSE: To assess MR imaging findings and clinical manifestations of @entity157 ( @entity157 ). MATERIALS AND METHODS: We retrospectively reviewed our experience with diffuse @entity157 from November 1994 to October 2001. MR imaging findings and clinical features were assessed. RESULTS: Twenty-two consecutive @entity1 with diffuse-type @entity157 (19 @entity1 and three @entity1 , age range 16-80 years [mean, 52 years]) were identified in a review of liver MR studies. This represented 13% of all @entity1 with @entity157 imaged during this time period. Diffuse @entity157 showed a permeative, infiltrative pattern with ill-defined borders and no evidence of convex margination in all cases. At least 50% of the liver volume was involved with @entity5 . @entity157 showed hypointensity in 15 @entity1 , mixed intensity in three, and isointensity in four on T1-weighted images; heterogeneous hyperintensity in 16 @entity1 ; and homogeneous hyperintensity in six on T2-weighted MR images. @entity157 showed patchy enhancement in 12 @entity1 , miliary enhancement in nine, and minimal enhancement in one on postcontrast early-phase images, and showed heterogeneous wash-out in all @entity1 on postcontrast late-phase images. Proximal portal venous @entity5 @entity715 was seen in all patients. Serum @entity160 ( @entity160 ) value was elevated (>10 ng/mL) in 14 of 18 @entity1 , and 13 showed a value greater than 500 ng/mL. The four @entity1 who did not have elevated @entity160 had @entity5 which were indistinguishable from those in @entity1 with elevated @entity160 ; they also did not have a distinctive clinical history. CONCLUSION: @entity157 was typically seen as an extensive, heterogeneous permeative @entity99 , with portal venous @entity5 @entity715 on MR images in all cases. Early enhancement, observed as patchy in 12 and miliary in nine of 22 @entity1 , was a distinctive imaging feature. Elevated serum @entity160 value was a common finding; however, 22% had normal values.
