Food inequality negatively impacts cardiac health in XXXX .

@entity1 @entity1949 @entity66 @entity95 @entity6973 @entity2118
BACKGROUND: Individuals with lower socioeconomic status experience higher rates of mortality and are more likely to suffer from @entity66 . While some studies indicate that @entity1 who suffer from social inequality suffer generally worse health, to our knowledge no controlled experiments of this nature have been done in any species. @entity6973 is a highly oxidized cross-linked aggregate consisting of oxidized protein and lipid clusters. This eminent terminal oxidation outcome accumulates within cells during aging process. METHODOLOGY/PRINCIPAL FINDINGS: Thirty two @entity95 were assigned into four groups randomly of eight each. The first group encountered food @entity1949 for eight weeks and was kept in an isolated situation. The second group was food deprived for eight weeks but encountered to other groups continuously. The third group suffered two weeks of @entity1949 and then received free access to food. The fourth group had free access to diet without any @entity1949 . All hearts were removed for histopathological evaluation. Cross-sections of hearts were examined by light microscopy for the presence of yellow-brown Lipofuscin pigment granules. Here we show that relative food @entity1949 can cause accumulation of @entity2118 . We find that cardiac Lipofuscin deposition increases the most in the inequitable condition in which food deprived individuals observe well-fed individuals. CONCLUSIONS/SIGNIFICANCE: Our findings demonstrate that a sense of inequality in food intake can promote aging more than food @entity1949 alone. These findings should be considered as a basis for further studies on the physiological mechanisms by which inequality negatively impacts health and well-being.
