Patterns of care and outcomes of XXXX in a tertiary care cancer centre in Pakistan.

@entity1 @entity632 @entity66 @entity900 @entity421 @entity3 @entity1499
OBJECTIVE: To present our experience of treatment outcomes in @entity421 @entity1 . METHODS: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data related to 74 adult @entity1 with @entity421 from 1995 to 2009. The treatment plan consisted of surgery preceded by neo-adjuvant chemotherapy followed by adjuvant chemotherapy. SPSS 16 was used for statistical analysis. RESULTS: Of the 74 @entity1 in the study, 58 (78%) were in the 18-29 age group with an overall male-to-female ratio of 3:1. The commonest site of disease was femur, 30 (43%). Of the 66 (89%) @entity1 undergoing definitive surgery, 59 (89.4%) had amputation. The remaining 7 (10.6%) limb salvage operations were in the neo-adjuvant chemotherapy group. Good histopathological response rates in high-dose @entity1499 containing regimens and other regimens were similar with an overall good response rate of 18/51 (35%). The commonest site of relapse was lung.Twelve out of 27 (44%) @entity1 with lung-only @entity3 underwent successful metastatectomy. For @entity1 with @entity66 at presentation 3-year event-free survival was 30%, and 3-year overall survival was 71%. For @entity1 with @entity3 at presentation 3-year overall survival was 45%. Median overall survival for @entity1 receiving high-dose @entity1499 and other regimens was 1.7 years vs 2.9 years. CONCLUSION: @entity421 treated with @entity900 / @entity632 based chemotherapy and surgery had good outcomes. The role of high-dose @entity1499 in @entity421 remains uncertain.
