Histologic and staging classification of XXXX : implications for therapy.

@entity1 @entity5 @entity0 @entity146
@entity0 has 20 different histologic descriptions grouped into four categories, A, B, C, and D, based on prognosis. An analysis of 3,902 @entity1 has revealed significant differences in outcome. Class A disease--for the most part in situ--was relatively benign, with a frequency distribution of 5%. Positive nodes were found in 1.6%, and five-year survival curves exceeded 91%. Class B (mucinous, medullary, etc) occurred in 4.1% of @entity1 . Fewer advanced stages indicated @entity146 , and survival at five years was 75%. The most common class, C (85%), had a five-year survival of 66%, closely related to stage. Class D @entity5 , 4.3% with ill defined, wildly infiltrative borders, and undifferentiation, were ominous with 33% demonstrating distant spread at first diagnosis. The five-year survival was only 46%. Epidemiologic findings revealed a high incidence of bilaterality and high family risk in some categories, but not in others. Mammography should be done in all class A lesions. A complete pretreatment metastatic survey is recommended for class D @entity1 , as well as those with @entity5 . Indications for various surgical and adjuvant therapies are described.
