Hitting them where it hurts? Low dose XXXX therapy.

@entity1 @entity662 @entity390 @entity1337 @entity158 @entity5889 @entity130
OBJECTIVE: To determine if low dose @entity5889 provides an adequate reduction in @entity158 with minimal side effects. METHODS: Prospective cohort of 115 @entity1 given @entity5889 by paramedics in Wales and the English borders. OUTCOME MEASURES: (1) Mean total dose of @entity5889 administered, change in @entity158 score, time to adequate @entity158 relief (score below four), and change in respiratory rate and systolic blood pressure; (2) proportion of @entity1 continuing to suffer moderate to severe @entity158 on arrival at hospital; (3) incidence of adverse events. RESULTS: Full data were obtained for all @entity1 . The mean total dose of @entity5889 administered was 6.09 mg (range 2.5 to 12.5 mg). This was significantly higher in @entity130 than ischaemic @entity662 @entity1 (7.03 versus 5.13 mg). The mean reduction in @entity158 score was -3.97 (95% CI -4.38 to -3.57, p<0.001). The mean time to adequate @entity158 relief (where this was achieved) was 15.7 minutes (95% CI 13.4 to 17.9 minutes). On arrival at hospital 60% of @entity1 (n=69, 95% CI 50.9 to 68.5%) still met ambulance criteria for @entity1337 (70.7% of @entity130 @entity1 and 49.1% with ischaemic @entity662 ). Systolic blood pressure fell by a mean of -3.67 (95% CI -6.76 to -0.58, p=0.02) and respiratory rate increased by a mean of 1.63 (95% CI 1.08 to 2.17, p<0.001). Two @entity1 complained of @entity390 (1.74%, 95% CI 0.5 to 6.0%). No other adverse events were reported. CONCLUSION: Low dose @entity5889 results in few adverse events, but offers poor @entity158 control for a high proportion of @entity1 .
