Prognostic value of DNA ploidy and XXXX oncoprotein overexpression in @entity420 of @entity355 .

@entity1 @entity2007 @entity355 @entity41 @entity5 @entity406 @entity3 @entity2031 @entity204 @entity420 @entity1722 @entity7145
BACKGROUND: During the last two decades, a rising incidence of @entity7145 has been observed in the Western world. The prognostic relevance of @entity5 -biological factors, such as DNA ploidy or @entity1722 overexpression, for overall survival following complete resection is still unknown. METHODS: In a retrospective study of 80 @entity1 with @entity420 of @entity355 , the prognostic significance of flow cytometric DNA ploidy determination was investigated. Overexpression of @entity1722 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of @entity406 fixed, paraffin embedded tissue sections of the @entity5 . RESULTS: The rate of @entity2007 was 86%. Aneuploidy was significantly correlated with lymph node @entity3 only. @entity1722 oncoprotein overexpression of the @entity5 was detected in 15 @entity1 (19%). A significant correlation was seen between @entity1722 overexpression and depth of @entity5 invasion, lymph node involvement, distant @entity3 , and status of @entity41 after resection (R category, International Union Against Cancer [UICC], 1987). All @entity5 with @entity1722 oncoprotein overexpression were aneuploid. In a multivariate Cox regression analysis for overall survival of those 62 @entity1 (78%) whose @entity5 resection was macroscopically and microscopically complete (R0-UICC), depth of invasion, distant @entity3 , and @entity1722 overexpression were independent prognostic factors. The relative risk of @entity204 due to recurrence was nearly identical for @entity1 with either @entity1722 oncoprotein overexpression or distant @entity3 : 4.06 (1.4-11.8) and 3.94 (1.6-9.5). In a multivariate Cox regression analysis of the subgroup of lymph node-negative @entity1 (n = 26), the ploidy status of the @entity5 (defined as near-diploid plus tetraploid versus aneuploid plus multiploid) was the only independent prognostic factor for overall survival. CONCLUSIONS: These findings demonstrate that DNA ploidy as well @entity2031 - @entity1722 oncoprotein overexpression are valuable prognostic factors in @entity1 with @entity420 of @entity5 resection.
