@entity12698 reverts XXXX -induced @entity9 through inhibiting @entity3115 / @entity3242 pathway in the mouse dorsal root ganglion.

@entity901 @entity1 @entity3115 @entity12698 @entity5 @entity3242 @entity694 @entity15114 @entity56 @entity14 @entity1996 @entity9
UNASSIGNED: @entity901 ( @entity15114 ) is the common and extremely potent anti-advanced @entity14 chemotherapeutic. Accumulating evidence reveals that @entity15114 evokes mechanical and cold @entity56 . However, the mechanism underlying these bothersome and dose-limiting adverse effects is poorly understood. It is well known that @entity1996 ( @entity1996 ) as well as @entity3115 ( @entity3115 )/Akt signaling mediate the @entity9 . But it is still unclear whether @entity1996 or @entity3115 /Akt signaling participates in the regulation of @entity15114 -induced @entity56 , as well as the linkage between @entity1996 and @entity3115 /Akt signaling in mediating @entity15114 -induced @entity56 . In this paper, we investigated the anti-nociceptive effect of @entity12698 , an inhibitor of @entity1996 , on the @entity15114 -induced @entity9 . We found that @entity15114 increased the expression of @entity1996 ( @entity1996 ) and @entity3242 in the lumbar 4-5 (L4-5) dorsal root ganglion (DRG). And the administration of @entity12698 alleviates the @entity15114 -induced @entity56 and suppresses the @entity1996 and @entity3115 / @entity3242 signaling. Our findings showed that @entity1996 and @entity3115 / @entity3242 signaling in DRG contributed to the @entity15114 -induced @entity9 . In addition, @entity12698 enhanced the @entity15114 -induced mortality of the @entity1 @entity694 cell line HCT-116. Thus, @entity12698 might play a dual role in @entity14 treatment: alleviating @entity15114 -induced @entity9 and facilitating the anti- @entity5 effects of @entity15114 through their synergistic role.
