A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in XXXX .

@entity1 @entity28 @entity6 @entity535 @entity1144 @entity367
OBJECTIVE: We investigated the impact of a three- @entity535 deletion (12Glu9) polymorphism in the alpha(2B)-adrenergic receptor gene on autonomic nervous function. The short form ( @entity367 (9)/ @entity367 (9)) of the polymorphism has previously been associated with a reduced basal metabolic rate in @entity28 subjects. Because autonomic nervous function participates in the regulation of energy metabolism, there could be a link between this polymorphism and autonomic nervous function. RESEARCH METHODS AND PROCEDURES: Data of a 10-year follow-up study with 126 nondiabetic control subjects and 84 type 2 @entity6 @entity1 were used to determine the effects of the 12Glu9 polymorphism on autonomic nervous function. A deep breathing test and an orthostatic test were used to investigate parasympathetic and sympathetic autonomic nervous function. In addition, cardiovascular autonomic function was studied using power spectral analysis of heart rate variability. RESULTS: No significant differences were found in the frequency of the 12Glu9 deletion polymorphism between nondiabetic and @entity6 subjects. The nondiabetic @entity1 with the @entity367 (9)/ @entity367 (9) genotype, especially those with @entity1144 , had significantly lower total and low-frequency power values in the power spectral analysis when compared with other @entity1 . Furthermore, in a longitudinal analysis of 10 years, the decrease in parasympathetic function was greater in nondiabetic @entity1 with the @entity367 (9)/ @entity367 (9) genotype than in the @entity1 with the @entity367 (9)/ @entity367 (12) or @entity367 (12)/ @entity367 (12) genotypes. DISCUSSION: The results of the present study suggest that the 12Glu9 polymorphism of the alpha(2B)-adrenergic receptor gene modulates autonomic nervous function in Finnish nondiabetic @entity1 . In the nondiabetic @entity1 with the @entity367 (9)/ @entity367 (9) genotype, the general autonomic tone is depressed, and vagal activity especially becomes impaired with time. Furthermore, this association is accentuated by @entity1144 .
