XXXX in columnar-lined @entity355 . Analysis of 13 esophagectomies.

@entity1 @entity355 @entity75 @entity189 @entity420 @entity1141
From 1977 to 1982, 13 @entity1 with @entity420 arising in the distal esophagus lined by columnar epithelium underwent esophagectomy with detailed analysis of the pathologic specimen. In three @entity1 , @entity189 was detected before @entity1141 occurred. In five @entity1 , the ectopic mucosa was discontinuous, prolonged cranially by islands of columnar epithelium scattered in the squamous mucosa. Variable degrees of @entity1141 were found in the columnar epithelium in seven specimens in areas of intestinal metaplasia. In four @entity1 with high-grade @entity1141 , several foci of @entity189 were identified. They were scattered over the whole length of the ectopic mucosa. These data strongly suggest that @entity420 develops from @entity1141 , the real @entity75 . Careful periodic screening must be carried out in @entity1 identified as having @entity355 . @entity1141 may be detected and located by endoscopy with dye spraying with directed biopsies. @entity1 with high-grade @entity1141 should undergo esophagectomy with resection of the whole ectopic mucosa because they are at high risk for development of @entity189 .
