Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with XXXX .

@entity1 @entity725 @entity227 @entity5494 @entity75 @entity726 @entity735 @entity1358 @entity389
OBJECTIVE: To examine microcystic inner nuclear layer (INL) changes in @entity735 and to determine associated factors. DESIGN: Retrospective, cross-sectional, observational study. METHODS: Two hundred seventeen eyes of 133 @entity1 with @entity725 ( @entity725 ), 41 eyes of 32 @entity1 with @entity726 and 181 normal eyes of 117 subjects were ultimately included. @entity389 were examined with infrared fundus images and with 19 vertical spectral domain optical coherence tomography (SD-OCT) images in the macular area. RESULTS: Microcystic INL changes were observed in 6.0% of eyes with @entity725 , but none of the normal eyes or eyes with @entity726 showed microcystic INL changes. The proportion of eyes with advanced @entity726 was significantly larger (P = 0.013) in eyes with @entity75 than without. The @entity227 ( @entity5494 ) slope was also significantly worse (P = 0.027) in eyes with @entity75 . No significant differences were observed in age, sex, refraction, axial length, intraocular pressure, or @entity5494 value between eyes with and without @entity389 . In several cases, @entity389 occurred along with @entity227 . The retinal nerve fiber layer (RNFL) thickness (P = 0.013) and @entity1358 ( @entity1358 ) + inner plexiform layer thickness (P = 0.023) were significantly lower in areas with @entity75 than without. The INL was also significantly thicker (P = 0.002) in areas with @entity75 . CONCLUSIONS: @entity389 in @entity735 are closely associated with RNFL and @entity1358 thinning and correlated with worse @entity5494 slope. These INL lesions may indicate focal and progressive damage in @entity726 .
