Anhydrous @entity16313 polymer gels for the topical delivery of XXXX /water sensitive compounds.

@entity16313 @entity26 @entity3089 @entity3090 @entity653 @entity35018
PURPOSE: The purpose of this study was the development and evaluation of an anhydrous @entity653 -based @entity16313 gel in order to study the stability of the @entity26 /water-sensitive agent @entity3089 ( @entity3090 ). METHODS: Various @entity16313 polymers were investigated rheologically at concentrations of 0.25-1% using a Brookfield viscometer in order to evaluate their ability to form anhydrous @entity653 -based formulations. The addition of @entity35018 was evaluated in order to create a gel that can be utilized for the incorporation of more lipophilic compounds. The suitability of standard neutralizers and their useful concentrations were determined to develop guidelines for formulation optimization. An accelerated stability study was performed at 50 degrees C to evaluate the degradation of @entity3090 in an anhydrous @entity653 gel. RESULTS: It was found that @entity16313 974 is the most efficient thickener for anhydrous @entity653 formulations. In contrast to aqueous gels, anhydrous gels are formed without the addition of neutralizers. The rank-order viscosity of the nonneutralized gels studied was 974 > 971 > 981 > Pemulen TR-2 approximately 980. The addition of neutralizers resulted in a further increase in gel viscosity, with a maximum being reached at a concentration of approximately 0.5% w/w. The incorporation of @entity35018 resulted in a concentration-dependent loss of gel viscosity. The stability data showed that no degradation of @entity3090 had occurred. CONCLUSION: It was shown that anhydrous @entity653 -based @entity16313 gels can be prepared without the need for neutralization. Such vehicles are promising for the incorporation of @entity26 /water-sensitive drugs.
