Mosquito Akirin as a potential antigen for XXXX control.

@entity1 @entity66 @entity19 @entity4409 @entity281 @entity197 @entity311 @entity313 @entity2637
BACKGROUND: The control of vector-borne diseases is important to improve @entity1 and @entity4409 worldwide. @entity311 is one of the world's @entity66 and is caused by protozoan parasites of the genus @entity2637 , which are transmitted by Anopheles spp. mosquitoes. Recent evidences using Subolesin (SUB) and Akirin (AKR) vaccines showed a reduction in the survival and/or fertility of blood-sucking ectoparasite vectors and the @entity281 with vector-borne pathogens. These experiments suggested the possibility of using AKR for @entity311 control. METHODS: The role of AKR on @entity2637 @entity281 and on the fitness and reproduction of the main @entity311 vector, @entity313 was characterized by evaluating the effect of akr gene knockdown or vaccination with recombinant mosquito AKR on parasite @entity281 levels, fertility and mortality of female mosquitoes. RESULTS: Gene knockdown by RNA interference in mosquitoes suggested a role for akr in mosquito survival and fertility. Vaccination with recombinant @entity197 AKR reduced parasite @entity281 in mosquitoes fed on immunized @entity19 when compared to controls. CONCLUSIONS: These results showed that recombinant AKR could be used to develop vaccines for @entity311 control. If effective, AKR-based vaccines could be used to immunize wildlife reservoir hosts and/or @entity1 to reduce the risk of pathogen transmission. However, these vaccines need to be evaluated under field conditions to characterize their effect on vector populations and pathogen @entity281 and transmission.
