Elevated serum @entity414 levels are associated with @entity67 in XXXX with dilated cardiomyopathy.

@entity1 @entity64 @entity712 @entity52812 @entity9400 @entity67 @entity1002 @entity414
OBJECTIVE: To assess whether serum @entity414 , which is a marker of impaired oxidative metabolism, might correlate with @entity1002 in @entity1 with @entity712 ( @entity712 ). BACKGROUND: @entity414 levels, which are frequently elevated in @entity1 with @entity712 , correlate with leg vascular resistance. The effects of elevated levels of @entity414 on cardiac function in @entity1 with @entity712 have never been evaluated. METHODS: We studied 150 outpatients with @entity712 who came to our @entity712 clinic. @entity1 underwent a complete echo-Doppler examination, with measurement of mitral E wave and mitral A wave velocities, E/A ratio, E wave deceleration time (DtE), left ventricular volumes, ejection fraction, and @entity64 volume. A restrictive mitral filling pattern (RMFP) was defined as either @entity9400 <140 milliseconds. RESULTS: Mean age was 62.2 +/- 7.8 years (86% male); 24 @entity1 (16%) had an RMFP. @entity1 with an RMFP had significantly higher @entity414 levels compared with @entity1 without RMFP (0.48 +/- 0.14 mmol/L vs 0.38 +/- 0.08 mmol/L, respectively, P <.001). @entity414 levels correlated significantly with mitral E wave velocity (r =.22, P <.01), E/A ratio (r =.21, P <.05), DtE (r =.26, P <.01), and RMFP (P =.0001). There was no correlation between @entity414 and left ventricular volumes, ejection fraction, or @entity64 volume. In a multivariate model, @entity414 predicted @entity52812 independently of renal function, diuretic dose, and left ventricular volumes. CONCLUSION: Elevated @entity414 levels are associated with @entity67 in @entity712 . Xanthine oxydase inhibition in @entity1 with @entity712 might theoretically result in an improvement of diastolic function.
