Neuroretinal rim area and ocular haemodynamic parameters in @entity1 with normal-tension XXXX with differing intracranial pressures.

@entity1 @entity428 @entity726 @entity450 @entity1781 @entity432
PURPOSE: To assess the differences in the neuroretinal rim area (NRA) and ocular haemodynamic parameters in @entity1 with normal-tension @entity726 (NTG) with differing @entity428 ( @entity428 ) values. METHODS: 40 @entity1 (11 males) with NTG (age 61.1 (11.5)) were included in the prospective study. Intraocular pressure (IOP), non-invasive @entity428 , @entity450 ( @entity450 ) and confocal laser scanning tomography for @entity1781 ( @entity1781 ) structural parameters were assessed. Non-invasive @entity428 was measured using a novel two-depth Transcranial Doppler device. @entity450 was measured using colour Doppler imaging in the @entity432 ( @entity432 ). The @entity1 were divided into two groups, @entity428 >=  and <8.3   mm   Hg, based on the statistical median of @entity428 . p Values <0.05 were considered statistically significant. RESULTS: @entity1 with NTG had mean @entity428 8.8 (2.5) mm   Hg, IOP 13.6 (2.1) mm   Hg, @entity1781 size 2.3 (0.6) mm(2), NRA 1.2 (0.4) mm(2). Lower @entity428 was correlated with decreased NRA (r=0.51, p=0.001). @entity1 with NTG having @entity428 (N=20) had significantly lower NRA 1.0 (0.3) mm(2), than @entity1 with NTG having higher @entity428 (N=20) 1.3 (0.3) mm(2), p=0.002, although there were no significant differences in @entity1781 size (accordingly, 2.2 (0.5) and 2.3 (0.6) mm(2), p=0.55) and IOP (accordingly, 13.5 (2.4) and 13.7 (1.8) mm   Hg, p=0.58). @entity1 with NTG having @entity428 had significantly lower @entity432 blood flow velocities (peak systolic volume (PSV) 28.7 (8.0), end-diastolic volume (EDV) 6.9 (3.0) cm/s), compared with @entity1 with NTG having higher @entity428 (PSV 35.5 (10.2), EDV 9.4 (4.1) cm/s), p<0.04. CONCLUSIONS: @entity1 with NTG having @entity428 have decreased neuroretinal rim area and @entity432 blood flow parameters compared with @entity1 having higher @entity428 . Further longitudinal studies are needed to analyse the involvement of @entity428 in NTG management.
