Immunohistochemical analysis of the expression of cellular transcription NFkB ( @entity9135 ), @entity1178 ( @entity1639 and @entity1178 ), and JAK/STAT in XXXX .

@entity1 @entity9135 @entity4104 @entity1198 @entity4016 @entity1178 @entity1639 @entity379 @entity6897 @entity7116 @entity4430 @entity1201
UNASSIGNED: @entity1201 is a disease whose clinical spectrum depends on the cytokine patterns produced during the early stages of the immune response. The main objective of this study was to describe the activation pattern of cellular transcription factors and to correlate these factors with the clinical forms of @entity1201 . Skin samples were obtained from 16 @entity1 with the tuberculoid (TT) form and 14 with the lepromatous (LL) form. The histologic sections were immunostained with anti- @entity1639 and anti- @entity1178 monoclonal antibodies for investigation of @entity1178 , anti-NFkB @entity9135 for the study of NFkB, and anti- @entity4016 , @entity6897 , @entity4104 , and @entity7116 for investigation of the JAK/STAT pathway. Cells expressing @entity6897 were more frequent in the TT form than in LL lesions (P = .0096), in agreement with the protective immunity provided by @entity379 . @entity7116 was also more highly expressed in the TT form than in the LL form (P = .0098). This transcription factor is essential for the development of a @entity1198 response because it is associated with interleukin-12. NFkB ( @entity9135 ) and @entity7116 expression in the TT form showed a strong and significant correlation (r = 0.7556 and P = .0007). A moderate and significant correlation was observed between @entity4016 and @entity7116 in the TT form (r = 0.6637 and P = .0051), with these factors responding to interleukin-12 in @entity1198 profiles. The results suggest that @entity6897 , @entity4016 , and NFkB, together with @entity7116 , contribute to the development of cell-mediated immunity, which is able to contain the proliferation of @entity4430 .
