Changes in 'A' antigenic sites in XXXX . An immunoautoradiographic study.

@entity1 @entity308 @entity981 @entity12191 @entity2150 @entity11998 @entity1778 @entity74
Using a quantitative immunoautoradiographic technique with simultaneously exposed internal standards, antigenic sites on A1, @entity12191 , A2 and A2B erythrocytes were quantitated. The binding of purified radioiodinated rabbit anti-A antibodies was studied by the direct incubation technique. 61 normal individuals and 44 @entity1 suffering from @entity1778 and other @entity74 such as @entity11998 vera (PV) and @entity2150 ( @entity2150 ) were investigated. Among the normal volunteers, antigenic sites gradually increased up to 3 months of life, later on they were comparable with the values of adults. A reduction of more than 50% in the antigenic sites was observed in all cases of @entity2150 . 50-70% of @entity1 with various forms of @entity1778 had a decrease in antigenicity. 1 @entity1 suffering from acute unclassified @entity1778 showed two populations of red cells. This case differed from natural O/A1 chimerism where A1 erythrocytes had normal antigenicity while in the patient, A1 antigens were @entity308 . 2 @entity1 (1 with @entity981 , 1 with @entity2150 ) who were investigated after allogenic bone marrow transplantation had a marked decrease in antigenic sites. Reasons for A antigenic variations in @entity74 are discussed.
