Hemofiltration and peritoneal dialysis in XXXX -associated @entity810 in Vietnam.

@entity1 @entity295 @entity281 @entity520 @entity9231 @entity810 @entity1011 @entity204 @entity166
BACKGROUND: In some parts of the world, peritoneal dialysis is widely used for renal replacement in @entity810 . In resource-rich countries, it has been supplanted in recent years by hemodialysis and, most recently, by hemofiltration and associated techniques. The relative efficacy of peritoneal dialysis and hemofiltration is not known. METHODS: We conducted an open, randomized comparison of pumped venovenous hemofiltration and peritoneal dialysis in @entity1 with @entity281 -associated @entity810 in an @entity166 referral hospital in Vietnam. RESULTS: Seventy adult @entity1 with severe @entity9231 malaria (48 @entity1 ) or @entity295 (22 @entity1 ) were enrolled; 34 were assigned to hemofiltration and 36 to peritoneal dialysis. The mortality rate was 47 percent (17 @entity1 ) in the group assigned to peritoneal dialysis, as compared with 15 percent (5 @entity1 ) in the group assigned to hemofiltration (P=0.005). The rates of resolution of @entity520 and of decline in the serum @entity1011 concentration in the group assigned to hemofiltration were more than twice those in the group assigned to peritoneal dialysis (P<0.005), and renal-replacement therapy was required for a significantly shorter period. In a multivariate analysis, the odds ratio for @entity204 was 5.1 (95 percent confidence interval, 1.6 to 16) and that for a need for future dialysis was 4.7 (95 percent confidence interval, 1.3 to 17) in the group assigned to peritoneal dialysis. The cost of hemofiltration per survivor was less than half that of peritoneal dialysis, and the cost per life saved was less than one third. CONCLUSIONS: Hemofiltration is superior to peritoneal dialysis in the treatment of @entity281 -associated @entity810 .
