Spatial heterogeneity of mucosal blood flow during @entity63 -reperfusion injury of XXXX stomach investigated by laser Doppler perfusion imaging.

@entity4485 @entity63 @entity1819 @entity1066 @entity37532 @entity5828 @entity35 @entity551 @entity3137
Spatial alterations in blood flow during the development of @entity3137 induced by @entity63 -reperfusion in @entity35 were determined with a two-dimensional laser Doppler tissue perfusion imager. The @entity35 were anesthetized with @entity4485 , and the stomach was exteriorized on a stage; the mucosa was then sequentially scanned. The mucosa was constantly superfused with 0.1 N @entity5828 in physiological saline. Systemic arterial pressure was continuously monitored and blood was stepwisely withdrawn from the femoral artery by 20-mmHg stage and then maintained at 20 mmHg for 20 min. The shed blood was reinfused and the stomach was removed 30 min later. Under control conditions, the average perfusion of the forestomach was usually greater than that in the glandular stomach. When systemic blood pressure was stepwisely decreased, the extent of @entity551 perfusion unit was always greater than that in systemic blood pressure, but mucosal perfusion appeared to be uniformly decreased throughout the stomach. Ten min after reperfusion, a hypoperfused area began to appear in the corpus near the greater curvature, and this area subsequently increased. The area of @entity1066 formation corresponded with the hypoperfused area in the gastric mucosa 30 min after reperfusion. Pretreatment with @entity37532 , a platelet-activating factor antagonist, significantly attenuated the hypoperfusion induced by reperfusion and also prevented @entity1819 . Our results suggest that hypoperfusion in the mucosal microcirculation is indeed an important factor contributing to the localized occurrence of @entity3137 and that the laser Doppler perfusion imager is useful for the detection of local hypoperfused areas in the gastric mucosa.
