Serum cytokine changes after gastric resection or gastrectomy for XXXX .

@entity1 @entity650 @entity295 @entity310 @entity347 @entity379 @entity701 @entity1199 @entity3646 @entity688 @entity356 @entity1851
BACKGROUND/AIMS: Although essential for postoperative recovery, excessive surgical stress response leads to higher rate of serious postoperative complications, such as @entity295 and @entity347 . Exact regulation of surgical stress response is not yet known. Still, our ability to modify surgical stress response severity has led to diminished postoperative morbidity and mortality rates and development of fast-track surgery. In this study we tried to further clarify the roles of several cytokines in surgical stress response regulation. METHODOLOGY: We measured leukocyte count and serum concentrations of @entity1851 , @entity1199 , @entity650 , @entity688 , @entity310 , @entity379 and @entity701 in @entity1 undergoing gastrectomy or gastric resection for @entity356 . Blood samples were collected preoperatively, 3 hours, 24 hours and 48 hours postoperatively. We also grouped our @entity1 according to operation type and duration and then compared measured values between groups. RESULTS: Elevated postoperative leukocyte count and serum concentrations of @entity3646 , @entity650 , @entity688 and @entity701 were measured, all peaking at 3 hours postoperatively. Also, serum @entity650 concentration was higher after longer operations, and leukocyte count was higher after gastrectomy. CONCLUSIONS: The synchronicity of postoperative elevation of @entity3646 , @entity650 and @entity688 concentrations, each having different role in surgical stress response regulation, might indicate that, in order to determine surgical stress response severity, several cytokines should be measured simultaneously.
