Hippocampal shape deformation in female XXXX with unremitting major depressive disorder.

@entity1 @entity1400 @entity131 @entity3831 @entity3202 @entity194 @entity4696 @entity528
BACKGROUND AND PURPOSE: The hippocampal @entity194 of @entity4696 has been known, but the region shape contractions of the hippocampus in @entity4696 were inconsistent. Spheric harmonic shape analysis was applied to the hippocampus in female @entity1 with unremitting @entity4696 to evaluate morphometric changes of the hippocampus. MATERIALS AND METHODS: Shape analysis was performed by using T1-weighted MR imaging in 21 female @entity1 with @entity4696 and 21 age- and sex-matched healthy controls. Manually segmented hippocampi were parameterized, and the point-to-point-based group difference was compared by using the Hotelling T-squared test. The partial correlation analyses were tested between clinical variables and shape changes. RESULTS: Both hippocampal volumes were small in @entity1 with @entity4696 compared with healthy controls, and the right hippocampal volume was negatively correlated with the number of episodes at marginal significance. Regional shape contractions were found in the ambient gyrus, basal hippocampal head, posterior subiculum, and dorsal hippocampus of the left hemisphere. The right hippocampus showed a similar pattern but was less @entity3202 compared with the left hippocampus. A negative correlation was found between the @entity3831 and shape deformation in the @entity1400 , ambient gyrus, posterior subiculum, and gyrus fasciolaris of the left hippocampus. CONCLUSIONS: We showed @entity194 and regional shape contractions in the hippocampi of @entity1 with @entity4696 , which were more dominant on the left side. The causes of @entity131 could be the hypersecretion of glucocorticoids contributing to @entity528 or the failing of adult neurogenesis in the dentate gyrus.
