Percutaneous ultrasound guided implantation of VX2 for creation of a @entity95 XXXX model.

@entity5 @entity99 @entity95
Creation of a VX2 @entity5 model has traditionally required a laparotomy and surgical implantation of @entity5 fragments. Open surgical procedures are invasive and require long procedure times and recovery that can result in post-operative morbidity and mortality. The purpose of this study is to report the results of a percutaneous ultrasound guided method for creation of a VX2 model in @entity95 livers. A total of 27 New Zealand white @entity95 underwent a percutaneous ultrasound guided approach, where a VX2 @entity5 fragment was implanted in the liver. Magnetic resonance imaging was used to assess for @entity5 growth and necropsy was performed to determine rates of tract seeding and metastatic disease. Ultrasound guided @entity5 implantation was successful in all 27 @entity95 . One @entity95 died 2 days following the implantation procedure. Two @entity95 had no @entity5 seen on follow-up imaging. Therefore, @entity5 development was seen in 24/26 (92%) @entity95 . During the follow-up period, tract seeding was seen in 8% of @entity95 and 38% had extra-hepatic metastatic disease. Therefore, percutaneous ultrasound guided @entity5 implantation safely provides reliable @entity5 growth for @entity99 in a @entity95 model with decreased rates of tract seeding, compared to previously reported methods.
