Fat cell metabolism in different regions in XXXX . Effect of menstrual cycle, pregnancy, and lactation.

@entity1 @entity1063 @entity5523
Adipose tissue lipolysis and @entity5523 ( @entity5523 ) activity were studied in biopsies from the femoral and abdominal depots in healthy @entity1 during early or late menstrual cycle, pregnancy, and the lactation period. When the differences in cell size were taken into account, basal lipolysis was similar in both regions in nonpregnant @entity1 . During lactation, however, lipolysis was significantly higher in the femoral region. The lipolytic effect of @entity1063 (10(-6) M) was significantly less in the femoral region in the nonpregnant @entity1 and during early pregnancy. However, the lipolytic response was the same in both regions in lactating @entity1 . @entity5523 activity was higher in the femoral than in the abdominal region except during lactation when a marked decrease in the @entity5523 activity was seen in the femoral region. The @entity5523 activity in the abdominal region remained unchanged in all @entity1 groups. The results imply that in both nonpregnant and pregnant @entity1 lipid assimilation is favored in the femoral depot. During lactation, however, the metabolic pattern changes; the @entity5523 activity decreases and lipid mobilization increases in this depot. These changes are much less pronounced in the abdominal region. Thus, fat cells from different regions show a differential response during pregnancy and lactation. These results suggest that the adipose tissue in different regions may have specialized functions.
