Contribution of dysregulated serum @entity1760 to mortality in hemodialysis XXXX with @entity3528 : a 3-year cohort study.

@entity1 @entity1851 @entity66 @entity3528 @entity955 @entity972 @entity204 @entity1760
BACKGROUND: The extent of contribution of disturbed @entity1760 balance to mortality remains unclear among hemodialysis @entity1 . METHODS: This was a cohort study involving 3276 @entity1 on maintenance hemodialysis at 86 facilities in Japan from 2008 to 2010 who had @entity3528 ( @entity3528 ). Baseline serum @entity1760 (sMg) values were categorized into quintiles ( <=2.3, >2.3-2.5, >2.5-2.7, >2.7-3.0 and >3.0 mg/dL), and the middle quintile was set as the reference. Outcome was all-cause @entity204 . Independent contribution to all-cause @entity204 was assessed via Cox regression to generate population-attributable fractions (PAFs). RESULTS: A total of 2165 @entity1 from 68 facilities were analyzed. The lowest quintile of sMg was positively associated with lower serum @entity972 and albumin levels, higher @entity1851 ( @entity1851 ) levels and prevalence of @entity955 and @entity66 than the other quintiles. The highest sMg quintile was positively associated with higher @entity972 levels, and negatively associated with lower serum albumin levels and higher intact parathyroid hormone and @entity1851 levels and prevalence of @entity66 than the other quintiles. During a median follow-up of 3 years, the lowest and the second lowest quintiles of sMg were associated with all-cause @entity204 [adjusted hazard ratio (HR) 1.737, 95% confidence interval (95% CI) 1.200-2.512 and HR 1.675, 95% CI 1.254-2.238, respectively). Point estimates of adjusted HRs of the highest and the second highest sMg quintiles were higher than those of the middle quintile for all-cause @entity204 . Adjusted PAFs of lower sMg and of higher and lower sMg for all-cause @entity204 were 24.0% (95% CI 13.0-35.0%) and 30.7% (95% CI 14.5-46.8%), respectively. CONCLUSION: In hemodialysis @entity1 with @entity3528 , dysregulated sMg is an important contributor to all-cause @entity204 . Further studies are warranted to examine whether or not correction of sMg improves survival.
