Short-term effect of androgen deprivation on intraluminal pressure and contractility of the XXXX epididymis.

@entity3033 @entity3429 @entity35 @entity3800 @entity2472
Short-term effects of bilateral castration, @entity3429 and unilateral efferent duct ligation on intraluminal pressures and spontaneous @entity2472 in different regions of the epididymis were studied in the @entity35 . Ligation of the efferent ducts for 5 days did not alter pressures or spontaneous @entity2472 in any region of the epididymis. However, bilateral castration produced time-dependent changes in pressures and @entity2472 in different segments. In the caput, the amplitude, but not the basal pressure or the frequency, of spontaneous @entity2472 increased by Day 1 after operation. In the corpus, increments in the basal pressure and the amplitude of @entity2472 occurred by Day 5 whilst the frequency of @entity2472 was not changed. Similar effects were observed in the cauda by 3 days after castration. Changes in all regions of the epididymis were also mimicked by @entity3429 treatment (10 mg/ @entity35 per day, s.c. for 21 days). In addition, this drug increased the amplitude of @entity2472 in the cauda. The effect of castration was abolished by @entity3033 (0.2 mg/kg per day, i.m. for 5 days). The results support the suggestion that an enhancement of sperm transport through the @entity35 epididymis occurs shortly after castration. The results also suggest that, in normal @entity35 , @entity3800 suppress the contractility of the epididymal tubule to ensure an optimal rate of sperm transport.
