Predictability of 1-h postload plasma XXXX concentration: A 10-year retrospective cohort study.

@entity6 @entity2998 @entity164 @entity209 @entity731 @entity413
AIMS/INTRODUCTION: Elevated 1-h postload plasma @entity413 concentration (1hPG) during oral @entity413 tolerance test has been linked to an increased risk of @entity164 2 @entity6 and a poorer cardiometabolic risk profile. The present study analyzed the predictability and cut-off point of 1hPG in predicting @entity164 2 @entity6 in normal @entity413 regulation (NGR) subjects, and evaluated the long-term prognosis of NGR subjects with elevated 1hPG in @entity413 metabolism, kidney function, metabolic states and @entity731 . MATERIALS AND METHODS: A total of 116 Han Chinese classified as NGR in 2002 at the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, were investigated. Follow-up was carried out in 2012 to evaluate the progression of @entity413 metabolism, kidney function, @entity209 and @entity2998 . RESULTS: The areas under receiver operating characteristic curves were higher for 1hPG than FPG or 2hPG (0.858 vs 0.806 vs 0.746). The cut-off value of 1hPG with the maximal sum of sensitivity and specificity in predicting @entity164 2 @entity6 in NGR subjects was 8.85  mmol/L. The accumulative incidence of @entity164 2 @entity6 in subjects with 1hPG >= 8.85  mmol/L was higher than those <8.85  mmol/L (46.2% vs 3.3%, P  =  0.000; relative risk 13.846, 95% confidence interval 4.223-45.400). On follow up, the prevalence of @entity209 and abnormal carotid intima-media thickness in the subjects with 1hPG >= 8.85  mmol/L tended to be higher compared with those <8.85  mmol/L. CONCLUSIONS: 1hPG is a good predictor of @entity164 2 @entity6 in NGR subjects, and the best cut-off point is 8.85  mmol/L. Some tendency indicates that NGR subjects with 1hPG >= 8.85  mmol/L are more prone to @entity209 and @entity2998 .
