Inspiratory pressure-volume curves obtained using automated low constant flow inflation and automated occlusion methods in @entity649 XXXX with a new device.

@entity1 @entity649 @entity2507 @entity1166
OBJECTIVE: To compare the inspiratory volume pressure (VP) curves of the respiratory system (rs) produced by static occlusion (OCC) and dynamic low constant flow inflation (LCFI) methods using a new device in @entity649 ( @entity649 ) @entity1 . SETTING: A multidisciplinary 24-bed ICU in a tertiary university hospital. @entity1 : Eleven intubated and mechanically ventilated @entity1 with @entity649 . MEASUREMENTS AND RESULTS: OCC and LCFI methods were performed using the same ventilator, which had been specifically implemented for this purpose. LCFI of 5, 10, and 15 l/min and OCC were applied in a random order at zero end-expiratory positive pressure. Airway pressure was measured both proximal (P(ao)) and distal (P(tr)) to the endotracheal tube. @entity1166 ( @entity1166 ) and maximal slope (C(max,rs)) were estimated using unbiased iterative linear regressions. @entity1166 (rs) was obtained in all @entity1 under LCFI and in nine @entity1 under OCC. With LCFI of 5, 10, 15 l/min and OCC the average @entity1166 (rs) values were 12.2 +/- 3.9, 12.9 +/- 4, 14.3 +/- 3.4, and 11.9 cm @entity2507 for P(ao) and 11.9 +/- 3.9, 11.5 +/- 3.3, 12.5 +/- 3.4 and 11.8 +/- 4.4 for P(tr), respectively. Only the mean values of @entity1166 (rs) for P(ao) with LCFI at 15 l/min were significantly different from those obtained for OCC. The C(max,rs) values found with the two methods were similar. CONCLUSIONS: An LCFI less than or equal to 10 l/min seems to be a quick, safe, and reliable method to determine @entity1166 (rs) and C(max,rs) at the bedside.
