IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone XXXX .

@entity1 @entity3 @entity158
BACKGROUND: To determine the optimal single-dose radiotherapy schedule for @entity158 from bone @entity3 in a multi-centre, international, randomised trial. @entity1 AND METHODS: 651 @entity1 were randomised to either 8Gy (n=325) or 4Gy (n=326) radiotherapy. @entity158 at 4, 8, 12, 24 and 52weeks was assessed using a Categorical Scale (CS) and a Visual Analogue Scale (VAS). The primary endpoint was response at 4weeks. RESULTS: There was no significant difference in @entity1 demographics and other co-variates. The complete response (CR) rate and ORR (complete or partial response) for all follow-up times were higher after 8Gy (p=0.02). The Kaplan-Meier actuarial rate (categorical scale) at 4weeks for ORR was 80% after 8Gy compared to 68% after 4Gy (p=0.0015). 117 re-treatments were given of which 72 were in the 4Gy group and 45 in 8Gy arm (p=0.01). CONCLUSIONS: There was a marked consistent difference in @entity158 relief at all time points in favour of 8Gy. These data reinforce the case for single dose 8Gy radiotherapy to be recommended for metastatic @entity158 in all healthcare settings.
