[Therapeutic immunoadsorption in XXXX ].

@entity1 @entity8 @entity548 @entity177 @entity1576 @entity7860
The extraction of circulating antiglomerular basement membrane (GBM) antibodies by plasmapheresis (PP) has allowed the prognosis of @entity7860 to markedly improve. Immunoabsorption (IA) may improve the results of PP upon allowing more effective immunoglobulin extraction. Two @entity1 with @entity7860 were treated with IA. A rapid decrease was observed in the serum levels of anti GBM antibodies and improvement in @entity1576 . In one of the @entity1 this regimen was administered following the observation of a lack of clinical response of @entity548 in three PP sessions (9 liters of treated plasma). In this @entity1 , the IA processed 39 liters of plasma and the method was found to be equally effective on reinstatement (29 liters) on the occasion of a relapse in the pulmonary symptoms presented at three weeks after the first treatment. Both cases showed @entity8 . In one case this was incipient and the treatment was associated with non progression of the @entity8 , normalization of the urine sediment and preservation of renal function. In the second case treatment was initiated at an advanced disease state with no changes in dialysis needs. Immunoadsorption has shown to be effective in the treatment of @entity548 in @entity7860 . Onset of treatment at an early stage of the @entity8 may avoid progression to @entity177 .
