Influence of hysterectomy on the fibrinolytic activity of plasma of XXXX with intact ovarian function.

@entity1 @entity2289 @entity1420 @entity1456 @entity53 @entity1031 @entity432 @entity715 @entity65
Hysterectomies are frequently required operations in gynecology. Several studies have reported an association between premenopausal hysterectomy and the risk of @entity65 . However, the pathophysiological linkages between these two conditions have not been elucidated. In recent years it has been shown that a decrease in plasma fibrinolytic activity is associated with increased risk of @entity715 . Furthermore, it has been known that the uterus is a very finbrinolytic active organ. In the present study we investigated the hypothesis that hysterectomy may lead to a decrease in plasma fibrinolytic activity, and thereby increase the risk for @entity1031 . Fibrinolytic parameters of plasma were investigated in 26 @entity1 before and 6 weeks after premenopausal hysterectomy. Euglobulin lysis time (ELT), a global measure of plasma fibrinolytic activity, and the levels of @entity1456 (tPA) and @entity2289 ( @entity2289 ) were not different before and after hysterectomy. The ELT difference before and after @entity432 , which is a good indicator for the risk of @entity715 , was also not significantly changed after hysterectomy. @entity53 -17 beta, @entity1420 , LH, FSH and sex hormone binding globulin displayed no significant changes after hysterectomy. Furthermore, the hormone measurements also indicated that the @entity1 were premenopausal. There were no correlations between the hormone values and fibrinolytic parameters. These data indicate that premenopausal hysterectomy does not lead to changes in plasma fibrinolytic activity.
