The minimum percentage of triolein emulsion for studying cerebral vascular permeability with least XXXX .

@entity4 @entity468 @entity2657
BACKGROUND: Triolein emulsion infusion into the brain produces transiently increased vascular permeability. OBJECTIVES: The purpose of this study was to find the minimum percentage of triolein emulsion required for studying vascular permeability with minimal @entity2657 . MATERIALS AND METHODS: Sixty healthy @entity468 were divided into six groups according to the concentration of emulsified triolein infused into the carotid artery: group 1, 0.125% (n = 10); group 2, 0.25% (n = 10); group 3, 0.5% (n = 10); group 4, 1% (n = 10); group 5, 2% (n = 10); and group 6, saline infusion (control group, n = 10). T2-, T1- and contrast enhanced T1-weighted MR images were obtained 2 hours after infusing triolein emulsion. Contrast enhancement ratios (CERs) and signal intensity ratios (SIRs) versus contralateral hemispheres were calculated. Statistical analysis was performed by analysis of variance followed by Tukey's test. P values of  <= 0.05 were considered significant. RESULTS: The lesion hemispheres showed mild hyperintensity due to @entity4 on T2-weighted images, and contrast enhancement on post-contrast T1-weighted images in @entity468 of group 1-5. CERs showed statistically significant differences between the control group and group 3 (P = 0.006), group 4 (P = 0.003), and group 5 (P < 0.001). However, SIRs were significantly different between the control group and group 5 only (P < 0.001). CONCLUSION: The minimum concentration of triolein emulsion required to increase vascular permeability adequately with minimal @entity2657 in a cat model was 0.5%.
