Overall and central adiposity and XXXX risk in the sister study.

@entity1 @entity5 @entity0
BACKGROUND: Greater body mass index (BMI), a measure of overall adiposity, is associated with a higher risk of @entity0 . The role of central adiposity, often measured by waist circumference, is less well understood, especially among premenopausal @entity1 . The objective of the current study was to examine multiple measures of adiposity in relation to @entity0 in a prospective cohort study. METHODS: A total of 50,884 Sister Study cohort @entity1 aged 35 to 74 years were enrolled from 2003 through 2009. Inclusion criteria for the cohort included having a sister previously diagnosed with @entity0 . Trained study personnel measured height, weight, and waist and hip circumference during a home visit and study @entity1 completed a detailed questionnaire. Using Cox regression analysis, we estimated multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) for @entity0 risk associated with adiposity measurements, considering @entity5 subtype and menopausal status. RESULTS: In total, 2009 @entity0 were diagnosed during follow-up (mean   =   5.4 years). Weight, BMI, waist circumference, and waist-to-hip ratio were found to be positively associated with overall @entity0 risk and HRs were greater among postmenopausal @entity1 , those with hormonally responsive @entity5 , and @entity1 who were not currently using postmenopausal hormones. In models that adjusted for BMI, waist circumference associations persisted among both postmenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.16 [95% CI 1.01-1.35] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 1.10-1.54]) and premenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.56 [95% CI 1.19-2.04] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 0.91-1.87]). CONCLUSIONS: Findings from this large, prospective study with examiner-measured body size indicate that waist circumference is independently and positively associated with both premenopausal and @entity0 risk. @entity5 2015;121:3700-3708.    2015 American @entity5 Society.
