Blood XXXX Concentrations After Transversus Abdominis Plane Block in Neonates: A Prospective Observational Study.

@entity1 @entity1341 @entity137 @entity158
BACKGROUND: @entity158 can have instant and prolonged consequences to behavioral and neurologic outcomes in neonates. Although the use of transversus abdominis plane (TAP) block to minimize @entity158 has been demonstrated in neonates, no data regarding the safety of this procedure are available for this @entity1 population. For instance, it is unknown whether plasma levels of local anesthetics are safe in neonates after TAP blocks. The main objective of the current investigation was to evaluate plasma @entity1341 concentrations in neonates having an ultrasound-guided TAP block. METHODS: The study was a prospective, observational study. After general anesthesia was induced, neonates received an ultrasound-guided TAP block with 0.125% @entity1341 and a total volume of 1 mL/kg. Dried blood spot samples were obtained and analyzed for @entity1341 levels at 0, 5, 15, 30, 60, 120 minutes, 4, and 24 hours after the TAP block. RESULTS: Ten neonates were included in the study. The highest 99% upper prediction limit for blood concentration, 0.38   g/mL, occurred at the 30-minute interval, but it was significantly lower than potentially toxic plasma levels (1.5-2.0   g/mL). The highest individual concentration was 0.26   g/mL and occurred at the 30-minute interval. None of the @entity1 demonstrated any potential signs of @entity137 . CONCLUSIONS: Our results suggest a low risk of @entity137 in neonates after a TAP block. Future studies to determine the efficacy of the TAP block to minimize @entity158 in this @entity1 population are warranted.
