Immunoreactive @entity1486 levels in female and @entity2675 and its association with steroid hormone receptors and XXXX age.

@entity1 @entity172 @entity263 @entity0 @entity1420 @entity2675 @entity5 @entity342 @entity1486
@entity1486 (PSA) is believed to be a highly specific marker for normal or cancerous prostatic tissue. We recently found that immunoreactive PSA (IR-PSA) is present in 30% of @entity0 cytosols (from 525 @entity0 @entity1 ). In this paper we analyzed a new series of 750 @entity0 cytosols, obtained from 744 @entity1 and six @entity1 , for IR-PSA. The positivity rates in the old and new series were very similar (approximately 30%). Combining the two series of @entity0 @entity1 , we examined the associations between IR-PSA and @entity172 (ER) or @entity1420 (PR) receptors, or @entity1 age. We found that IR-PSA positivity rate declines with age. @entity263 were highly associated with either ER-positive or PR-positive @entity5 alone. However, analysis in a subset of @entity5 that combine the two receptors, ER(-)/PR(-), ER(+)/PR(-), ER(-)/PR(+), and ER(+)/PR(+), revealed that IR-PSA was only associated with PR, and no relationship was found between IR-PSA and ER. We speculate that the presence of IR-PSA in @entity0 may be associated with the PR action and that the association between PSA and ER is indirect due to the known association between ER and PR. As five of the six @entity2675 were found negative for IR-PSA, it is suggested that @entity342 may not be involved in the presence of IR-PSA in @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)
