Genetically determined differences in noradrenergic function: The spontaneously XXXX @entity35 model.

@entity3264 @entity101 @entity1246 @entity71 @entity3391 @entity2915 @entity148 @entity35 @entity1063
UNASSIGNED: While genetic predisposition is a major factor, it is not known how development of @entity71 ( @entity71 ) is modulated by early life stress. The spontaneously @entity101 @entity35 (SHR) displays the behavioral characteristics of @entity71 (poorly sustained attention, impulsivity, @entity2915 ) and is the most widely studied genetic model of @entity71 . We have previously shown that SHR have disturbances in the noradrenergic system and that the early life stress of maternal separation failed to produce @entity148 -like behavior in SHR, contrary to control Sprague-Dawley and @entity35 -Kyoto (WKY) who showed typical @entity148 -like behavior in later life. In the present study we investigated the effect of maternal separation on approach behavior (response to a novel object in a familiar environment) in preadolescent SHR and WKY. We also investigated whether maternal separation altered GABAA and @entity3391 receptor-mediated regulation of @entity1063 release in preadolescent SHR and WKY hippocampus. We found that female SHR, similar to male SHR, exhibited greater exploratory activity than WKY. Maternal separation significantly increased GABAA receptor-mediated inhibition of @entity3264 -stimulated release of @entity1063 in male and female SHR hippocampus but had no significant effect in WKY. Maternal separation had opposite effects on @entity3391 receptor-mediated inhibition of @entity1063 release in SHR and WKY hippocampus, as it increased inhibition of both @entity3264 -stimulated and depolarization-evoked release in SHR hippocampus but not in WKY. The results of the present study show that noradrenergic function is similarly altered by the early life stress of maternal separation in male and female SHR, while @entity1246 - and @entity3264 -regulation of @entity1063 release remained unaffected by maternal separation in the control, WKY, @entity35 . This article is part of a Special Issue entitled SI: Noradrenergic System.
