The occurrence of cheyne-stokes respiration in XXXX : the effect of age.

@entity1 @entity67 @entity712 @entity299
INTRODUCTION: Up to 50% of adults with @entity712 ( @entity712 ) and left @entity67 demonstrate Cheyne-Stokes respiration (CSR), although the mechanisms remain controversial. Because CSR has been minimally studied in @entity1 , we sought to assess the prevalence of CSR in @entity1 with low and high output @entity712 . We hypothesized that the existence of CSR only in @entity1 with low output @entity712 would support the importance of circulatory delay as a CSR mechanism. METHODS: Thirty @entity1 participated: 10 @entity1 with @entity712 , 10 matched @entity1 with no @entity299 , and 10 adults with @entity712 . All @entity1 underwent an in-laboratory polysomnographic sleep study. RESULTS: @entity712 @entity1 's average age (  SEM) was 3.6        2.1 years vs. 3.7        2 years in the age-matched control group. The average ejection fraction of three @entity1 with low output @entity712 was 22        6.8%. The remaining seven had normal-high cardiac output. Compared to control @entity1 , @entity712 @entity1 were tachypneic and tachycardic during stable sleep (55.1        6.7 vs. 26.9        3 breath/min and 127.6        8.7 vs. 97.6        6.9 beats/min, respectively, p   <   0.05 for both). They had shorter total sleep time (195        49 vs. 373        16 min, p   <   0.05) with a low sleep efficiency of 65.6        6%. None of the @entity1 had a pattern of CSR at any time during the studies while the adults with @entity712 had 40% prevalence of CSR. CONCLUSIONS: The complete absence of CSR in our sample of @entity1 with @entity712 compared to the 40% prevalence in the adults with @entity712 we studied, suggests that CSR may be an age-dependent phenomenon. Thus, we speculate that regardless of the exact mechanism which drives CSR, age is an over-riding factor.
