Neuronal @entity842 synthase immunoreactivity in the @entity840 liver: distribution and colocalization with XXXX and calcitonin gene-related peptide.

@entity1 @entity840 @entity70749 @entity6892 @entity842
AIMS/BACKGROUND: The innervation pattern of the @entity840 liver is similar to that of the @entity1 liver. However, many aspects of the distribution of the neuronal isoform of the enzyme @entity842 synthase ( @entity70749 ) in the @entity840 liver and its colocalization with neuropeptides remain to be elucidated. METHODS: The distribution of @entity70749 was studied in fixed @entity840 liver by light microscopic immunohistochemistry. Confocal analysis was used to determine its colocalization with @entity6892 (NPY) or calcitonin gene-related peptide (CGRP). RESULTS: @entity70749 -immunoreactive ( @entity70749 -IR) nerves were observed in relation to hilar and interlobar vessels and in Glisson's capsule. A few @entity70749 -IR ganglia were observed in the extrahepatic bile duct and close to the interlobar portal triads. In addition, @entity70749 -IR fibers were located in the interlobular portal triads and pervading the parenchyma. Moreover, @entity70749 -IR nerves were demonstrated for the first time in the larger central veins and in the hepatic vein. @entity70749 -NPY and @entity70749 -CGRP colocalizations were detected in the fibromuscular layer of the bile duct and periductal plexus, respectively. CONCLUSIONS: These results support the phylogenetic conservation of the @entity70749 -IR hepatic innervation and its possible contribution to the regulation of hepatic blood flow and certain hepatic functions.
