[Cutaneous large B-cell leg-type XXXX occurring on a leg burn].

@entity1 @entity588 @entity706 @entity3145 @entity5 @entity229 @entity786 @entity14546 @entity20630 @entity2282 @entity4042 @entity1892 @entity1200 @entity1891 @entity4096
BACKGROUND: Primary cutaneous @entity1892 form a heterogeneous group of lymphoid proliferations found on the skin. We report a case of primary leg-type cutaneous large @entity1892 occurring on the site a previous leg burn. A few rare cases of @entity706 forming on burn scars have been described, but these concern primary @entity706 of the T-cell phenotype. CASE REPORT: An 85-year-old @entity1 with a history of a burn to the left leg 17 years ago, previously treated with several skin grafts, presented numerous ulcerative budding lesions on the scar area. Histological examination of the skin biopsy revealed the existence in the skin ulcers of atypical large lymphoid cells having an immunoblastic or centroblastic morphology and shown by immunohistochemistry to be of the B-cell phenotype, thereby evoking a diagnosis of large @entity1892 . The @entity706 cells were positive for @entity14546 / @entity20630 and @entity588 , and more weakly for @entity4042 , but negative for @entity2282 . The staging examination revealed only cortical lysis of the left tibia. Temporary initial regression was achieved by polychemotherapy comprising @entity786 , @entity1891 and @entity229 in combination with rituximab. DISCUSSION: This case is novel in that it involves primary large @entity1892 , leg type, occurring on @entity3145 . @entity4096 and lymphatic stasis have already been incriminated in the genesis of this type of @entity706 ; the prior @entity1200 at the burn site may have also contributed to the development of this @entity5 .
