Comparison of 4D CT, Ultrasonography, and 99mTc Sestamibi SPECT/CT in Localizing Single-Gland XXXX .

@entity1 @entity459 @entity2286 @entity3243 @entity2742
OBJECTIVE: The present study was designed to evaluate 4D computerized tomography (CT) as a means of localizing abnormal @entity3243 in @entity459 ( @entity2742 ). STUDY DESIGN: Case series with expertized image review. SETTING: Tertiary care hospital. SUBJECTS AND METHODS: A total of 38 @entity1 were recruited for study, all of whom had undergone focused parathyroidectomy for single-lesion primary @entity2742 between June 2011 and September 2013. In each @entity1 , 3 imaging procedures were performed: cervical ultrasonography (US), (99m)Tc-sestamibi SPECT/CT (SeS), and 4D CT. Collective imaging data were blindly reviewed and compared. RESULTS: 4D CT outperformed US and SeS in terms of sensitivity (P = .27), specificity (P = .01), positive predictive value ( @entity2286 ) (P < .01), negative predictive value (NPV) (P = .19), and accuracy (P < .01). In 7.9% (3/38) of @entity1 , 4D CT provided specific anatomic information that was unaffordable by US and SeS. Localization by 4D CT correlated with tissue parathyroid hormone level (P = .02), maximum diameter (P = .01), and volume (P < .01) of abnormal @entity3243 . CONCLUSION: 4D CT proved helpful in localizing target @entity3243 of primary @entity2742 that were missed by traditional imaging.
