[Occupation-related lung diseases in hard metal production and manufacturing. An XXXX ?].

@entity1 @entity137 @entity3673 @entity55 @entity565 @entity5303 @entity56 @entity1953 @entity221
The clinical heterogeneity of hard metal disease lung with its two basic forms, i.e. hart metal @entity55 and hard metal @entity565 , supports the view of different pathogenetic mechanisms. @entity1953 , which is generally considered the noxious agent in hard metal diseases, is cytotoxic on the one hand and allergenic on the other. Four typical, extensively investigated cases are presented, i.e. @entity3673 , @entity56 , @entity137 . The immunological results were negative in the @entity1 with @entity3673 . A hard metal grinder with typical occupational @entity56 showed a high level of precipitating antibodies against Aureobasidium pullulans, a well-known antigen in humidifier @entity221 and sequoiosis. The inhalative provocation test induced on both @entity1 with hard metal @entity565 an immediate and prolonged, i.e. a dual asthmatic reaction. Only the @entity1 with @entity56 due to @entity1953 and a positive epicutaneous test of the delayed type and a positive scratch tests of the immediate type with @entity5303 .
