The contribution of fast-FLAIR MRI for lesion detection in the brain of XXXX with systemic @entity792 .

@entity1 @entity17 @entity63 @entity75 @entity1252 @entity1701 @entity2883 @entity9468 @entity792
Fast fluid-attenuated inversion recovery (fFLAIR) is more sensitive that conventional or fast spin echo T2-weighted magnetic resonance imaging (MRI) for detecting lesions in the brain of @entity1 with @entity63 , inflammatory, or @entity17 diseases of the CNS. We investigated whether the use of fFLAIR also increases the sensitivity of brain MRI assessment in @entity1 with systemic @entity792 . @entity9468 ( @entity9468 ) dual-echo and fFLAIR scans of the brain were obtained from @entity1 affected by @entity1252 ( @entity1252 ) with (NSLE, n = 9) and without clinical CNS involvement (n = 15), Beh  et disease (n = 5), @entity2883 (n = 9), and @entity1701 (n = 6). @entity75 were counted and classified according to their size and their location by two observers by consensual agreement. The total lesion volume was measured using a semiautomated technique for lesion segmentation on both @entity9468 and fFLAIR scans. The imaging modalities showed brain hyperintense lesions in all 9 @entity1252 @entity1 with CNS involvement, 5 of 15 @entity1252 @entity1 without CNS involvement, 5 of 9 @entity1 with @entity2883 , 1 of 5 with Beh  et disease, and 3 of 6 with @entity1701 . A total of 342 lesions were seen on both sequences; 88 were seen only on @entity9468 and 54 only on fFLAIR scans. The average number of @entity75 per scan was higher on @entity9468 than on fFLAIR, since significantly more discrete (P<0.002) and small (P = 0.004) lesions were seen on @entity9468 than on fFLAIR. The median total lesion volume, however, was similar on @entity9468 and fFLAIR. Our study indicates that the use of fFLAIR does not improve the sensitivity of fast dual-echo MRI for detecting @entity75 in @entity1 with systemic @entity792 .
