XXXX codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis.

@entity1 @entity97 @entity3531 @entity5 @entity534 @entity876 @entity157 @entity7820
BACKGROUND: @entity157 ( @entity157 ) is one of the most common @entity5 worldwide. The @entity876 gene is frequently mutated in some histological subtypes of @entity157 . The role of @entity876 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The @entity876 @entity5 suppressor gene @entity7820 polymorphism has been associated with @entity157 . However, results were inconsistent. This meta-analysis was performed to estimate the association between @entity876 @entity7820 polymorphism and @entity157 or @entity157 infected by @entity97 / @entity3531 . METHODS: Electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of @entity7820 were chosen, and pooled odds ratio (OR) with 95  % confidence interval (CI) was used to assess the association. RESULTS: Ten published studies, including 1,371 @entity157 cases and 2,517 controls were identified. The overall results suggested that the variant genotypes were associated with the @entity157 risk (Pro/Pro vs. Pro/ @entity534  +  @entity534 / @entity534 : OR 1.355, 95  % CI 1.041-1.764, p  =  0.024). In the stratified analysis, individuals with the Pro/Pro in the recessive model had increased risk of @entity157 (OR 1.927, 95  % CI 1.127-3.297, p  =  0.017) in Caucasian. A symmetric funnel plot, the Begg's test, was suggestive of the lack of publication bias. There was no association between the @entity876 codon 72 polymorphism and @entity97 / @entity3531 -positive @entity157 . CONCLUSION: This meta-analysis suggests that @entity876 condon 72 Pro/Progenotypes are associated with increased risk of @entity157 in Caucasian. To validate this association, further studies with larger @entity1 worldwide are needed to examine the associations between this polymorphism and @entity157 .
