Endotoxin and intracerebroventricular injection of IL-1 and @entity568 induce XXXX brain @entity8280 .

@entity35 @entity3247 @entity568 @entity8280
Metallothioneins (MTs) are a family of proteins which in mammals is comprised of four isoforms ( @entity8280 -IV). @entity8280 and MT-II are expressed in many tissues, whereas @entity3247 is expressed exclusively in the central nervous system (CNS). In contrast to the liver, the knowledge of the regulation of the different MT isoforms in the brain is scarce. A number of cytokines have been shown to be important regulators of MT synthesis in vivo and in vitro. In accordance with this concept, the i.p. administration of endotoxin, which elicits the release of cytokines not only in peripheral tissues but also in the brain, caused an overall increase of @entity3247 levels in the @entity35 brain which was very significant in medulla + pons and cerebellum. Among the putative cytokines involved in endotoxin-elicited brain @entity3247 induction, interleukin-1 (IL-1) and @entity568 ( @entity568 ) are likely candidates. These cytokines have a variety of effects in the brain, and they are major regulators of @entity3247 synthesis in tissues such as the liver. Here we show the administration of IL-1 and @entity568 into the third ventricle increased @entity3247 protein levels in specific brain areas in the @entity35 . IL-1 tended to increase @entity3247 levels in all brain areas studied, but significantly in the striatum, hypothalamus, medulla + pons and cerebellum. The effect of @entity568 was more restricted, but a significant increase of @entity3247 levels was still observed in frontal cortex, hypothalamus and cerebellum. The results suggest that IL-1 and @entity568 are important regulators of brain @entity3247 and that these cytokines could mediate @entity8280 +II induction after an immunological insult.
