@entity34312 prevents XXXX -induced cough during general anesthesia induction: A randomized controlled trial.

@entity1 @entity3575 @entity681 @entity34312
BACKGROUND: Opioid-induced cough during induction of general anesthesia is a common phenomenon. @entity34312 , a partial  -receptors agonist and k-receptors antagonist, has been documented effectively suppressing @entity3575 -induced cough in general anesthesia induction. However, the effect of @entity34312 on @entity681 -induced cough is still unknown. METHODS: A total of 370 @entity1 (American Society of Anesthesiologists physical status I-II), aged 18-70 years, undergoing elective surgery, were randomly divided into a control group (group C) and a @entity34312 group (group D) (n=185 in each group). @entity1 received @entity34312 0.1mg/kg or an equal volume of 0.9% normal saline 2min prior to intravenous @entity681 (0.5 g/kg). The incidence and reflex degree of cough in @entity1 were evaluated within 2min after the injection of @entity681 in anesthesia induction period. RESULTS: No @entity1 in group D had cough and 59 @entity1 in group C had cough (severity of cough: mild, 7%; moderate, 11.4%; severe, 13.5%). The occurrence and reflex degree of cough in group D was significantly lower than that in group C (P=0.000). The highest heart rate (HR) and invasive blood pressure (IBP) values were higher in group C than those in group D (P<0.01) within 2min after @entity681 administration, althought these values remained within safe limits. CONCLUSION: The results of current study suggest that administration of @entity34312 0.1mg/kg may effectively prevent the occurrence and reflex degree of @entity681 -induced irritating cough in general anesthesia induction in @entity1 .
