Adult hypocellular acute XXXX with lymphoid differentiation.

@entity1 @entity10730 @entity5953 @entity7571 @entity3335 @entity469 @entity44004 @entity3052 @entity2282 @entity1778 @entity982 @entity2467 @entity2280
The @entity3052 ( @entity3052 ) previously also termed smouldering @entity1778 , almost always exhibit myeloid differentiation. Very rare cases of hypocellular @entity3052 with lymphoid differentiation have been reported, usually in @entity1 . This paper describes two cases (an 87-year-old @entity1 and a 79-year-old @entity1 ) in whom the blood findings were suggestive of @entity3052 . @entity982 -embedded bone marrow biopsy specimens revealed similar findings in both @entity1 : there was severe hypocellularity, the cells of normal hemopoiesis were greatly reduced in number, and there was a diffuse increase in blast cells, which represented more than 50% of nucleated marrow cells. The blasts coexpressed @entity10730 and @entity2280 and were negative for @entity3335 , @entity2467 , @entity469 and @entity44004 esterase. For the first time immunohistochemical @entity5953 / @entity2280 doublestainings are provided, which revealed the blasts in one case to coexpress @entity5953 and @entity2280 . All the blasts were @entity7571 -positive and 20% were also @entity2282 -positive. In the other case, 20% of the blasts were @entity7571 -positive, 30% coexpressed @entity5953 and @entity2280 by doublestaining, and showed a clonal rearrangement of the immunoglobulin heavy chain gene. Thus a diagnosis of @entity3052 of lymphoid lineage, hypocellular variant, was made on the basis of immunohistochemical findings. The clinical course appears to be similar to that of @entity3052 , as neither @entity1 has developed @entity1778 during the one-year follow-up period.
