Comparison of endothelium-dependent relaxation in @entity291 intrapulmonary artery and vein by XXXX and @entity3365 .

@entity6708 @entity6693 @entity1617 @entity8262 @entity3897 @entity3365 @entity3352 @entity291 @entity934
This study was conducted to compare the influence of endothelium on mechanical responses of @entity291 intrapulmonary artery and vein to @entity934 ( @entity1617 ) and @entity3365 and to determine if a relationship exists between the responses and @entity8262 ( @entity6708 ) accumulation. @entity1617 and @entity3365 induced relaxation in artery and @entity3365 induced relaxation in vein. The relaxant responses in both vessels were abolished by rubbing the intimal surfaces, indicating that the relaxant responses depended upon the presence of a functionally intact endothelium. @entity6708 accumulation was temporally associated with both @entity1617 - and @entity3365 -induced endothelium-dependent relaxation. Both the relaxant responses and the accompanying @entity6708 accumulations were abolished or reduced markedly by intimal rubbing or pretreatment with @entity6693 . @entity3897 abolished relaxation and @entity6708 accumulation induced by @entity1617 in artery, but not relaxation and @entity6708 accumulation induced by @entity3365 . Whereas @entity3352 did not affect either @entity1617 - or @entity3365 -induced relaxation in artery, it slightly, but significantly, reduced @entity3365 -induced relaxation in vein. In contrast to its effect in artery, @entity1617 only induced contractile responses in vein and did not alter @entity6708 levels, whether or not functional venous endothelium was present. However, @entity1617 did relax veins when arterial endothelium was present in crossover experiments using a modified sandwich technique. At concentrations which induced endothelium-dependent relaxation in artery, @entity1617 similarly induced no, or only minimal, contraction in both artery and vein in which endothelium was functionally destroyed. These findings demonstrate that @entity291 intrapulmonary artery and vein exhibit endothelium-dependent relaxation in response to @entity3365 , and similar to @entity1617 -induced relaxation in the artery, @entity3365 -induced relaxation is associated closely with accumulation of @entity6708 .(ABSTRACT TRUNCATED AT 250 WORDS)
