XXXX : Comparisons with Intracranial Pressure Scores in Idiopathic Normal Pressure Hydrocephalus.

@entity1 @entity64 @entity1276 @entity428
BACKGROUND AND PURPOSE: Aqueductal @entity64 volume from phase-contrast MR imaging has been proposed for predicting shunt response in normal pressure @entity1276 . However, this biomarker has remained controversial in use and has a lack of validation with invasive intracranial monitoring. We studied how @entity64 compares with intracranial pressure scores in the presurgical work-up and clinical score, ventricular volume, and aqueduct area and assessed the @entity1 's response to shunting. MATERIALS AND METHODS: Phase-contrast MR imaging was performed in 21 @entity1 with probable idiopathic normal pressure @entity1276 . @entity1 were selected for shunting on the basis of pathologically @entity428 pulsatility. @entity1 with shunts were offered a second MR imaging after 12 months. Ventricular volume and transverse aqueductal area were calculated, as well as clinical symptom score. RESULTS: No correlations between @entity64 and preoperative scores of mean intracranial pressure or mean wave amplitudes were observed. Preoperative @entity64 was not different between @entity1 with shunts and conservatively treated @entity1 (P = .69) but was correlated with ventricular volume (R = 0.60, P = .004) and aqueductal area (R = 0.58, P = .006) but not with the severity or duration of clinical symptoms. After shunting, @entity64 (P = .006) and ventricular volume (P = .002) were reduced. A clinical improvement was seen in 16 of 17 @entity1 who had shunts (94%). CONCLUSIONS: Aqueductal @entity64 volume does not reflect intracranial pressure pulsatility or symptom score, but rather aqueduct area and ventricular volume. The results do not support the use of @entity64 for selecting @entity1 for shunting.
