Disease Recurrence Patterns and Analysis of Clinicopathological Prognostic Factors for Recurrence after Resection for Distal XXXX .

@entity1 @entity3 @entity5 @entity1126
UNASSIGNED: Surgical resection is the treatment of choice for @entity1126 . The aim of this study was to investigate disease recurrence patterns and prognostic factors for recurrence of @entity1126 after surgical resection. A retrospective study was performed on 122 @entity1 with @entity1126 who underwent R0 or R1 surgical resection at Korea University Guro Hospital from 1991 to 2010. Sites of initial disease recurrence were classified as locoregional or distant. Univariate and multivariate analyses were performed to investigate the factors affecting recurrence. Of the 122 @entity1 , 80 @entity1 developed recurrence. The disease-free survival rate was 63.1 per cent at one year and 36.4 per cent at three years. The patterns of recurrence at diagnosis were locoregional in 25 @entity1 , locoregional and distant @entity3 in 14 @entity1 , and distant @entity3 in 41 @entity1 . Multivariate analyses revealed that recurrence pattern, lymph node @entity3 , and differentiation are independent prognostic factors affecting disease-free survival. R status (marginal significance) and @entity5 differentiation were independent prognostic factors associated with locoregional recurrence. Differentiation and lymph node @entity3 were independent prognostic factors associated with distant @entity3 . The prognosis after recurrence was poor with a 1-year survival rate after recurrence of 26.1 per cent. Adjuvant chemo- or radiation therapy, delivered in @entity1 mainly with R1 resection or with presence of lymph node @entity3 , did not demonstrate the survival benefit. Significant factors for recurrence were @entity5 differentiation and lymph node @entity3 . Therefore, close follow-up and adjuvant therapy will be necessary in @entity1 with lymph node @entity3 or poorly differentiated @entity5 .
