Impact of the XXXX mode on @entity204 donor lungs.

@entity63 @entity4 @entity10459 @entity1763 @entity2224 @entity1167 @entity35 @entity204
BACKGROUND: Donation after @entity204 (DCD) organs could alleviate the shortage of donor lungs. This study aimed to assess the influence on lung injuries of the way in which @entity1167 was induced and to investigate the mechanisms leading to any differences. MATERIALS AND METHODS: Male @entity35 were allocated into three groups as follows: sham (no warm @entity63 ), @entity2224 ( @entity2224 ), and @entity1763 group. @entity1167 was induced by either @entity2224 by way of a fibrillator or @entity1763 caused by withdrawal of ventilation, which reflected uncontrolled and controlled DCD situations, respectively. The impact on lung flushing after 60  min of warm @entity63 time was evaluated (n  =  5, in each group). The physiological functions of the lungs in an isolated lung perfusion circuit were also evaluated with warm @entity63 time prolonged to 150  min (n  =  8, in each group). Messenger RNA expression levels of surfactant proteins (SPs) and inflammatory cytokines, pathologic findings, and high-energy phosphates of the lung tissues were investigated. RESULTS: In the @entity1763 group, flushing and physiological functions in the isolated lung perfusion circuit were the most severely affected. Reverse transcription-polymerase chain reaction and pathologic findings revealed depletion of @entity10459 in lung tissues of the @entity1763 group after reperfusion. The @entity2224 group was characteristic with elevated pulmonary vascular resistance. CONCLUSIONS: Lung injuries were mainly attributed to alveolar wall damage and depletion of SP in the @entity1763 group, and perivascular area prominent @entity4 in the @entity2224 group. DCD donor lungs were affected differently by the way in which @entity1167 was induced.
