Efficacy and tolerability of a sequential, artesunate suppository plus @entity8775 , treatment of severe XXXX .

@entity1 @entity66 @entity772 @entity8775 @entity9231 @entity810 @entity1613 @entity311 @entity204
Thirty @entity1 with severe @entity9231 were each given a total of 1600-mg artesunate suppository over three consecutive days followed by 1250 mg @entity8775 per os, divided into two doses which were given 12 h apart. All @entity1 were admitted for 28 days to the Bangkok Hospital for @entity66 , so that the efficacy and tolerability of the treatment could be assessed. All the @entity1 showed clinical improvement, with mean (S.D.) parasite and fever clearance times of 50.4 (13.0) and 70.7 (44.9) h, respectively. Two @entity1 with unrousable @entity772 ( @entity772 score < or = 8) on admittance regained consciousness 46 and 48 h post-treatment. One other @entity1 had @entity810 and required dialysis. Most @entity1 (80%) were @entity1613 , with a mean density of 184,344 parasites/microliters blood. No @entity204 occurred. Efficacy was evaluated in 25 of the @entity1 . The cure rate 28 days post-treatment was 92%. None of the @entity1 had major adverse effects although two had tenesmus and passed stools immediately after each suppository was administered. A fresh suppository had to be inserted when this occurred. The results indicate that artesunate suppositories followed by oral @entity8775 constitute a well-tolerated regimen with a high cure rate. The combination is suitable as an alternative treatment for severe @entity311 , particularly in @entity1 . Further, large-scale studies are required.
