Reduction of XXXX levels after single intra-articular and intramuscular @entity134 injection.

@entity1 @entity627 @entity134 @entity2339 @entity701 @entity8745
BACKGROUND: This study was undertaken to determine the influence of single intra-articular or intra muscular injections of @entity8745 on the @entity2339 . @entity1 AND METHODS: Twenty-one @entity1 with @entity627 who had never been treated with systemic glucocorticoids and had not received local injections of these agents for the preceding 2 months, were given 40 mg of @entity8745 . Group I (11 @entity1 ) received one intra-articular injection into the knee, and Group II (10 @entity1 ) received the same dose intramuscularly. RESULTS: In Group I, serum @entity701 levels were significantly decreased 24 hours after injection (228.2 +/- 8.7 nmol/L versus 193 +/- 16.3 nmol/L; P < 0.05). Serum @entity701 levels were decreased in 9 of the 11 @entity1 , by an average of 21.5%. Two @entity1 ' levels were below 138 nmol/L, which is considered to be the lower limit of normal range. Serum @entity701 levels were below normal range in 3 @entity1 72 hours after intra-articular @entity134 injection. In Group II, serum @entity701 levels were significantly decreased at 72 hours after injection (239.6 +/- 10.3 nmol/L versus 175.6 +/- 21.4 nmol/L; P < 0.01). Three @entity1 ' levels were below normal. By 72 hours postinjection, serum @entity701 concentrations in 9 of 10 @entity1 were decreased by an average of 31% compared to preinjection values. CONCLUSION: The present study suggests that decreased adrenocortical secretion, as reflected in depressed @entity701 levels, can result from a single, low-dose, intra-articular or intramuscular injection of depot corticosteroids.
