Selective Imaging of Malignant Ascites in a XXXX Model of Peritoneal @entity3 Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

@entity1 @entity3123 @entity295 @entity5 @entity4358 @entity19 @entity20962 @entity2768 @entity3 @entity1320
UNASSIGNED: The presence of @entity5 in advanced @entity5 @entity1 is associated with both a poor prognosis and quality of life with a risk of @entity1320 and @entity295 . Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate @entity5 from surrounding tissues. This study aimed to determine the utility of selective @entity4358 imaging in the abdominal cavity with a free radical probe and @entity20962 ( @entity2768 ) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between @entity4358 volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on @entity4358 in vivo, modeled by the injection of saline into the abdominal cavity of @entity19 . To demonstrate the utility of this method for disease, @entity5 in peritoneal @entity3 animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal @entity3 animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the @entity1 @entity3123 (SUIT-2). The image intensity with increasing @entity5 was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo @entity5 progression, as measured by bioluminescent imaging. These results suggest that @entity4358 signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for @entity5 with @entity5 @entity3 .
