@entity2631 : two distinct clinical variants of XXXX ?

@entity1 @entity75 @entity2631 @entity785
BACKGROUND: For nearly a century, the terms " @entity2631 " have been used interchangeably without defined clinical or histologic criteria. OBJECTIVE: To define the conditions " @entity2631 " by correlating the clinical and histologic features. METHODS: We retrospectively identified six @entity1 with @entity75 and nodules from 70 consecutive @entity1 with @entity2631 seen in the dermatology clinic. The clinical presentation and histopathological findings were reviewed. RESULTS: Six of 70 @entity1 with @entity2631 (45 systemic and 25 @entity2631 ) exhibited @entity75 . All these @entity1 had @entity785 . Clinically one @entity1 (case 1) had nodules; five (cases 2-6) had keloids. The nodular lesions had histologic findings consistent with keloid, while the keloidal plaques were variably keloids or @entity2631 histopathologically. There was no correlation between the clinical morphology and the histologic findings, except for cases 5 and 6. These @entity1 were African-American, with a family history of keloids and typical keloids clinically and histologically that developed from sites with normal skin. CONCLUSION: @entity2631 are clinical terms that describe keloidal and nodular lesions in @entity1 most commonly with @entity2631 . The clinicopathologic association is variable. Based on a review of the English literature and our series of six @entity1 , we identified two clinical variants; (1) @entity75 arising from sclerodermatous skin with histologic findings of keloid or @entity2631 , (2) typical keloids clinically and histologically, arising in normal skin in @entity1 with a family history of keloids. Awareness of these entities is important for proper diagnosis of the cutaneous lesions and for recognizing that the cutaneous findings may be a sign of @entity785
