HEM-10: A SEVERE HEMORRHAGIC SHOCK LEADS TO A DELAYED FRACTURE HEALING AND BIOMECHANICAL INSTABILITY IN A XXXX MODEL.

@entity19 @entity174 @entity190 @entity548
INTRODUCTION: The purpose of the study is to evaluate the effect of a severe @entity548 on @entity19 @entity174 healing. METHODS: The Fx-group received a fixateur extern and an osteotomy on the right femur. The THFx-group additionally received a pressure controlled @entity548 (35 mmHg over 90 minutes, afterwards resuscitation with Ringer solution). Animals of the Sham-group received implantation of a catheter and fixateur extern but no @entity190 or osteotomy. After 1, 2, 3, 4 or 6 weeks, animals were analyzed via X-ray,  CT and 3-point bending test. Statistical significance was set at p<0.05. Comparisons between groups were performed using the Mann-Whitney U test. RESULTS: One week after surgery, all fractured bones were macroscopically instable. After two weeks the Fx-group showed a stable bridging, whereas the bones of the group THFx were instable in 50% of the cases (Fig. 1). Interestingly, the 2-week THFx @entity19 showed a stable bridging with a @entity190 under 30% of the whole blood volume, whereas animals with a @entity190 higher than 30% showed an instable @entity174 . 3 weeks after surgery, the bones of both groups were bridged. First results of the 3-point binding tests showed a reduced tensile strength of the THFx groups after 2- and 3-weeks, in comparison to the Fx group.(Figure is included in full-text article.) CONCLUSION: : A @entity548 has a negative effect on the @entity174 healing. In this context the amount of the removed blood in terms of a '30% threshold' plays a decisive role.
