XXXX enhances and accelerates the expression of sensitization induced by coca paste indicating its relevance as a main adulterant.

@entity35 @entity2072 @entity5834
BACKGROUND AND OBJECTIVES: @entity5834 is an active adulterant found in several drugs of abuse including coca paste (CP). We had previously demonstrated that @entity5834 potentiated the acute stimulant effect induced by CP seized samples. The role of @entity5834 in the expression of sensitization elicited by a CP seized sample (CP1) was here evaluated. METHODS: CP1 (equivalent dose of 10   mg/kg of @entity2072 ), @entity2072 (pure, 10   mg/kg), a combination of @entity2072 10   mg/kg plus @entity5834 2.5   mg/kg (CP1-surrogate) and saline (control) were intraperitoneally injected in male @entity35 under two different sensitization schedules. Ambulatory locomotion was recorded in 58 animals. RESULTS: After five daily CP1 injections and 5   days of withdrawal, CP1-challenged animals displayed a more robust sensitization than @entity2072 -treated animals. When a 3 injections-regime of CP1-surrogate or @entity2072 was assayed, only CP1-surrogate was able to elicit sensitization. DISCUSSION AND CONCLUSIONS: @entity5834 enhances and accelerates the CP1-induced sensitization. SCIENTIFIC SIGNIFICANCE: Results may shed light on the fast and high dependence observed in CP users. (Am J Addict 2015;XX:XX -XX).
