@entity25306 suppresses proliferation and facilitates apoptosis of @entity1 @entity43 cells through upregulating microRNA  -29b and downregulating XXXX expression.

@entity43 @entity1 @entity1476 @entity5 @entity25306 @entity15702
UNASSIGNED: @entity25306 , an alkaloid extracted from medicinal plants of the genus Sophora, has a wide range of pharmacological effects. Previous studies have revealed that @entity25306 can inhibit proliferation and metastasis of @entity5 cells through reducing @entity1476 ( @entity1476 ) mRNA expression. However, the expression of @entity1476 in @entity43 is significantly higher than that in normal ovaries. Furthermore, the expression of microRNA  -29b ( @entity15702 ) in @entity43 is significantly lower than that in normal ovaries. Therefore, @entity1476 and @entity15702 are @entity5 suppressor factors involved in @entity43 . To evaluate the anti- @entity5 effects of @entity25306 the @entity1 @entity43 cell line was treated with @entity25306 at the concentrations of 0, 0.5, 1 and 2  mg/ml. Assessment of the proliferation and apoptosis of @entity1 cells showed that @entity25306 had an inhibitory effect on @entity43 cells. Furthermore, @entity25306 decreased the protein levels of @entity1476 and increased the expression levels of @entity15702 in @entity1 cells. Through transfection of @entity15702 precursor into @entity1 cells, it was demonstrated that @entity15702 regulated @entity1476 expression in @entity1 cells. In addition, anti  - @entity15702 antibodies were used to verify that the apoptotic effect of @entity25306 was due to upregulating @entity15702 and downregulating @entity1476 expression. These results showed that @entity25306 suppresses the proliferation and facilitates apoptosis of @entity1 @entity43 cells through upregulating @entity15702 and downregulating @entity1476 expression.
