XXXX -negative peptic ulcer. What is its aetiopathogenesis and treatment?

@entity10189 @entity2783 @entity117 @entity1066 @entity281 @entity8579 @entity1535 @entity1534 @entity14761 @entity30
Although the vast majority of peptic @entity1066 are widely considered as related to the germ @entity1534 , @entity1066 exhibiting absence of this @entity281 are increasingly seen in recent years. This fact has been partly related to a decreased prevalence of @entity1534 among the population, a consequence of improved hygiene and housing conditions. Causes in relation to @entity1534 -negative @entity1066 are: 1. Falsely negative @entity281 diagnostic tests. They represent 25% of @entity1066 considered as @entity1534 -negative in health-care practice (falsely negative diagnostic test 5%, previous or concomitant therapy with antibiotics, @entity1535 or proton pump inhibitors 20%). 2. @entity117 (ASA) or non-steroidal anti-inflammatory drug (NSAID) therapy. This is no doubt the most common cause, representing 50 to 60% of all @entity1066 . 3. Other causes ( @entity8579 , @entity1534 heilmannii, generalised gut disease such as @entity30 , @entity2783 , @entity14761 , etc.) may be responsible for less than 5% of all @entity1534 -negative @entity1066 . 4. " @entity10189 . Thus are considered @entity1066 for which no potential cause may be found, representing 5-15% of all @entity1066 . Acid hyper-secretion is probably an important factor in them.
