Exercise for XXXX with @entity263 : A Systematic Review and Meta-analysis.

@entity1 @entity410 @entity7126 @entity263 @entity5 @entity1295 @entity583 @entity65
CONTEXT: Exercise could be beneficial for @entity263 survivors. However, no systematic review across @entity5 stages and treatment types addressing potential benefits and harms exists to date. OBJECTIVE: To assess the effects of exercise on @entity5 -specific quality of life and adverse events in @entity263 trials. EVIDENCE ACQUISITION: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis. EVIDENCE SYNTHESIS: We included 16 randomised controlled trials (RCTs) involving 1574 @entity1 with @entity263 . Follow-up varied from 8 wk to 12 mo. RCTs involved @entity1 with stage I-IV @entity5 . A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 @entity1 measured @entity5 -specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome ( @entity7126 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate ( @entity7126 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for @entity5 , submaximal @entity410 , and lower body strength. We found no evidence of benefit for disease progression, @entity65 , or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, @entity583 ) were equivalent to those seen in controls. CONCLUSIONS: These results support the hypothesis that exercise interventions improve @entity5 -specific quality of life, @entity5 , submaximal @entity410 , and lower body strength. @entity1 SUMMARY: This review shows that exercise/physical activity interventions can improve quality of life, @entity1295 , @entity410 , and function for @entity1 with @entity263 .
