Evolution of XXXX therapy from a meta-analytical perspective.

@entity10189 @entity868 @entity115 @entity9110 @entity4581 @entity1535 @entity3621 @entity1534 @entity800
Even before the discovery of @entity1534 as their cause, chronic @entity3621 and @entity10189 were empirically treated with anti-infectious agents. However, it was not until that finding that an antibiotic approach began to be used systematically. The main aim of this article is to review the evolution of @entity1534 therapy from a meta-analytical perspective. Initially, antibiotic monotherapy had a minor efficacy on @entity1534 . Dual therapy including either @entity1535 compounds or proton-pump inhibitors (PPI) and one antibiotic also resulted in insufficient cure rates. @entity1535 -based triple therapy (the first used) and PPI-based triple therapies (combined with two antibiotics, including @entity115 , @entity9110 , or @entity4581 ) have been the most widely recommended. PPI-based regimens are superior to H2-antagonist-based ones. The influence of the type of PPI, the dose and the duration of the treatment will be discussed. Among the factors influencing the efficacy of therapy, resistance to @entity4581 and @entity868 are the most important risk factors for eradication failure. Several rescue therapies can be used. @entity1535 -based quadruple therapy is effective, but the complexity of the regimen and the associated adverse effects limit the compliance. PPI-based triple therapy with @entity115 and @entity800 is at least equally effective and better tolerated.
