Predictors of recurrence in XXXX .

@entity1 @entity5 @entity1911
BACKGROUND: The recurrence rate of @entity1911 after adrenalectomy is 6.5-16.5%. This study aims to identify predictors of recurrence and optimal biochemical testing and imaging for detecting the recurrence of @entity1911 . METHODS: In this retrospective study we reviewed all @entity1 who underwent adrenalectomy for @entity1911 during a 14-year period at a single institution. RESULTS: One hundred thirty-five @entity1 had adrenalectomy for @entity1911 . Eight @entity1 (6%) developed recurrent disease. The median time from initial operation to diagnosis of recurrence was 35  months. On multivariate analysis, @entity5 size >5  cm was an independent predictor of recurrence. One @entity1 with recurrence died, 4 had stable disease, 2 had progression of disease, and 1 was cured. Recurrence was diagnosed by increases in plasma and/or urinary metanephrines and positive imaging in 6 @entity1 (75%), and by positive imaging and normal biochemical levels in 2 @entity1 (25%). CONCLUSION: @entity1 with large @entity5 (>5  cm) should be followed vigilantly for recurrence. Because 25% of @entity1 with recurrence had normal biochemical levels, we recommend routine imaging and testing of plasma or urinary metanephrines for prompt diagnosis of recurrence.
