Medium-dose ultraviolet A1 phototherapy improves SCORAD index and increases mRNA expression of XXXX without direct effect on @entity1 b defensin-1, @entity688 , and @entity22597 .

@entity1 @entity483 @entity22597 @entity111 @entity272 @entity3646 @entity688 @entity16448
BACKGROUND: Effectiveness of ultraviolet (UV)A1 in flares of @entity483 ( @entity483 ) is thought to influence the expression of cytokines involved in its pathogenesis. The aim of the study was to investigate whether mRNA expression of @entity1 b defensin-1 ( @entity16448 ) correlates with that of interleukin (IL)-4, @entity688 , and @entity22597 in @entity272 in @entity483 before and after UVA1 phototherapy, to determine whether UVA1 decreases the expression of the aforementioned mediators, and to confirm whether changes in mRNA expression correspond with the clinical efficacy of UVA1. METHODS: Twenty-five @entity1 with @entity483 underwent medium-dose UVA1 phototherapy. Before and after UVA1, biopsies from acute @entity272 were studied using reverse transcription and real-time polymerase chain reaction. RESULTS: Levels of mRNA @entity16448 correlated with those of @entity688 and @entity22597 , levels of @entity3646 mRNA correlated with those of @entity688 and @entity22597 , and @entity688 expression correlated with that of @entity22597 , both before and after UVA1. Phototherapy with UVA1 improved SCORing of @entity483 (SCORAD) values, decreased @entity111 , and increased expression of @entity3646 . After UVA1, no difference was found in the mRNA expression of other molecules. The SCORAD index did not correlate with the expression of any examined mRNA either before or after UVA1. CONCLUSIONS: @entity16448 , @entity3646 , @entity688 , and @entity22597 are expressed in acute @entity272 in @entity483 , and their levels correlate with each other. UVA1 improves SCORAD and @entity111 and increases the expression of @entity3646 without direct effect on other molecules.
