XXXX Erythematous and Malignancy Risk: A Meta-Analysis.

@entity1 @entity96 @entity5 @entity1489 @entity2 @entity1252 @entity409 @entity1582 @entity1778 @entity150 @entity418 @entity1583 @entity1893 @entity978 @entity259 @entity320
BACKGROUND: Pilot studies have estimated @entity5 incidence in @entity1 with @entity1252 ( @entity1252 ). However, the results have been inconclusive. To ascertain the correlation between @entity1252 and @entity5 more comprehensively and precisely, we conducted a meta-analysis. METHODS: PubMed, the Cochrane Library and Embase databases through June 2014, were searched to identify observational studies evaluating the association between @entity1252 and @entity5 . The outcomes from these studies were measured as relative risks (RRs). A random or fixed effects model was chosen to calculate the pooled RR according to heterogeneity test. Between-study heterogeneity was assessed by estimating I2 index. Publication bias was assessed by Egger's test. RESULTS: A total of 16 papers, including 59,662 @entity1252 @entity1 , were suitable for the meta-analysis. Of these papers, 15 reported RRs for overall @entity5 , 12 for @entity1893 ( @entity1893 ) and @entity2 , 7 for @entity150 , 6 for @entity978 ( @entity978 ) and @entity1778 , 5 for @entity320 , and @entity96 , 4 for @entity1582 ( @entity1582 ), and @entity418 and 3 for laryngeal and @entity1489 . The pooled RRs were 1.28 (95% CI, 1.17-1.41) for @entity5 , 5.40 (95% CI, 3.75-7.77) for @entity1893 , 3.26(95% CI, 2.17-4.88) for @entity978 , 2.01(95% CI, 1.61-2.52) for @entity1778 , 1.45(95% CI, 1.04-2.03) for @entity1582 , 4.19(95% CI, 1.98-8.87) for @entity5 , 1.59 (95% CI, 1.44-1.76) for @entity2 , 1.86(95% CI, 1.21-2.88) for @entity418 , 3.21(95% CI, 1.70-6.05) for @entity96 , 3.67(95% CI, 2.80-4.81) for @entity5 , 2.11(95% CI, 1.12-3.99) for @entity150 , 1.51(95% CI, 1.12-2.03) for @entity1489 , 1.78(95% CI, 1.35-2.33) for @entity259 , and 0.65(95% CI, 0.50-0.85) for @entity320 . Only the meta-analyses of overall @entity5 , @entity1893 , and liver and @entity150 produced substantial heterogeneity (I2, 57.6% vs 74.3% vs 67.7% vs 82.3%). No apparent publication bias was detected except for @entity1893 studies. CONCLUSIONS: Our data support an association between @entity1252 and @entity5 , not only demonstrating an increased risk for @entity1893 , @entity978 , @entity1778 , and some @entity1583 , including laryngeal, lung, @entity409 , but also a reduced risk for @entity320 . Although an increased risk of @entity1582 , and esophageal, bladder and @entity1489 was identified from the accumulated data in these studies, this observation requires confirmation.
