Chronic green tea extract supplementation reduces hemodialysis-enhanced production of @entity273 and XXXX , @entity731 factors, and proinflammatory cytokines.

@entity1 @entity9784 @entity1851 @entity23382 @entity620 @entity26 @entity12919 @entity273 @entity731 @entity9482 @entity454
BACKGROUND: Oxidative stress increases in @entity1 with @entity454 and exaggerates the related comorbidities. OBJECTIVE: The aim of the study was to evaluate the effects of supplementation with decaffeinated green tea extract ( @entity23382 ) on hemodialysis-induced reactive @entity26 species, @entity731 risk factors, and proinflammatory cytokines. DESIGN: We enrolled 6 healthy subjects and 54 hemodialysis @entity1 for the study. First, the pharmacokinetics of one oral dose of @entity23382 was compared between healthy subjects (n = 6) and hemodialysis @entity1 (n = 10). Second, in the 10 hemodialysis @entity1 , we compared the antioxidant effects of 3 different doses (0, 455, and 910 mg) of oral @entity23382 with that of oral @entity620 (500 mg) during a hemodialysis session. Third, the other 44 hemodialysis @entity1 participated in a 7-mo interventional study, in which 30 @entity1 received placebo throughout and 14 @entity1 received @entity23382 (455 mg/d) from the third to the fifth month. RESULTS: After one oral dose, the hemodialysis @entity1 (n = 10) had later peaks and slower decay of plasma @entity23382 than did the healthy subjects. In the 10 hemodialysis @entity1 , @entity12919 supplementation reduced hemodialysis-enhanced plasma @entity9784 activity more effectively than did placebo or @entity620 . Between treatments with 455 or 910 mg @entity23382 , no significant difference was found in the reduction of plasma @entity9784 activity. @entity23382 also significantly reduced proinflammatory cytokine expression enhanced by hemodialysis. In the 7-mo interventional study, the 14 @entity1 who received daily supplementation of @entity23382 for 3 mo had less predialysis plasma @entity273 activity, lower @entity9784 activity, and lower @entity9482 , @entity1851 , and proinflammatory cytokine concentrations than did the 30 hemodialysis @entity1 who received placebo. CONCLUSION: @entity23382 reduce hemodialysis-induced production of @entity273 and @entity9784 , @entity731 risk factors, and proinflammation.
