[Ovulation induction therapy and malignant XXXX ].

@entity1 @entity43 @entity722 @entity1792 @entity4082 @entity5
In the authors' institute 1097 @entity1 received treatment for @entity43 between the 1st of January, 1960 and the 31st of December, 1997. 92 of them had @entity722 . In this study the link between ovulation induction therapy and @entity43 was analyzed with retrospective questionnaire. 236 questionnaires were shared out among @entity1 with @entity43 , who were treated between 1990 and 1997. 7 of 113 @entity1 , who gave correct answers to the questions (6.2%) received ovulation induction therapy. @entity43 developed in 2 of the cases during, and in 5 cases just 6-16 years after the @entity4082 - @entity1792 treatment. None of the 45 @entity1 with granulosa cell @entity5 received induction therapy. The number of @entity1 admitted because of @entity43 before and after the induction therapy was also compared. There was no significant increase in the occurrence of the @entity5 . Since 1986 in the in vitro fertilization program of the clinic nearly 1,500 @entity1 were treated with effected ovulation induction drugs causing superovulation. The authors don't know of any development of @entity43 , and 732 @entity1 have confirmed this fact. The number of @entity1 deceased in consequence of @entity43 in different age groups, and the distribution of the @entity1 population in every age group in Hungary, from the year of 1979 was also analyzed. There was no significant increase found in the number of deceased among the studied age groups, moreover a significant decrease among them could be observed. The link between ovulation induction therapy and @entity43 can neither be strengthen, nor deny by the result of the study, however the close relationship which seemed to be logical can be queried. To give an exact answer for the question a vast, long-term, prospective of retrospective follow-up case-control study is needed.
