The association of @entity165 absorption gene XXXX polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China.

@entity1 @entity1007 @entity71670 @entity71667 @entity21129 @entity71669 @entity453 @entity165 @entity71668
BACKGROUND: @entity1007 is a major risk factor for @entity453 ( @entity453 ). As @entity21129 is an important regulating factor for intestinal @entity165 absorption and plasma @entity165 level, the aim of the present study is to assess the association between @entity1 @entity21129 gene polymorphism and @entity453 among Han and Uighur Chinese. METHODS: We have conducted two independent case-control studies in Han Chinese (384 @entity453 @entity1 and 433 controls) and Uighur Chinese (506 @entity453 @entity1 and 351 controls) subjects. All subjects were genotyped for four kinds of SNPs ( @entity71667 , @entity71668 , @entity71669 and @entity71670 ) and SNP is used as a genetic marker for @entity1 @entity21129 gene. Genotyping was undertaken using TaqMan SNP genotyping assay, and the subjects' ethnicity and gender were considered in the analysis. RESULTS: We found that @entity71668 was associated with @entity453 in the dominant model (CC vs CG   +   GG) for the total Han Chinese population (n   =   200) and Han Chinese males (n   =   115) (P   =   0.004 and P   =   0.001, respectively). The difference remained statistically significant after multivariate adjustment (total: OR   =   1.687, P   =   0.004; male: OR   =   1.498, P   =   0.006). Further, for the total (n   =   817) and male (n   =   490) Han Chinese, the frequency of the haplotype (T-C-T-C) was significantly higher in the @entity453 @entity1 than in the controls (P   =   0.004 and P   =   0.002), and the frequency of the haplotype (G-G-T-C) was significantly lower in the @entity453 @entity1 than in the control subjects (P   =   0.013, P   =   0.007). In addition, for the total (n   =   857) and male (n   =   582) Uighur Chinese, we observed that @entity71667 was associated with @entity453 in an additive and recessive model (P   =   0.021 and P   =   0.009; P   =   0.048 and P   =   0.034). However, the difference did not remain statistically significant after multivariate adjustment. The overall distribution of @entity71668 , @entity71669 and @entity71670 genotypes, alleles and the frequency of the haplotype established by four SNPs showed no significant difference between @entity453 @entity1 and control subjects in the total, male and female Uighur Chinese. CONCLUSIONS: The results of this study indicate that CC genotype of @entity71668 and T-C-T-C haplotypes in @entity21129 gene is a possible risk genetic marker and G allele and G-G-T-C haplotypes is a possible protective genetic marker for @entity453 in male Han Chinese.
