Cell cycle-regulated factors in XXXX .

@entity1 @entity986 @entity5 @entity996 @entity4910 @entity876 @entity418 @entity105
Alterations of cell cycle-regulated genes play an important role in the process of @entity105 , and some of them are thought to be prognostic factors in @entity418 . The expressions of @entity876 , @entity986 , @entity996 and @entity4910 proteins were evaluated immunohistochemically in 144 @entity1 who underwent curative esophagectomy without any adjuvant therapy before surgery. @entity876 overexpression was observed in 99 (69%) out of the 144 @entity1 . No significant correlation was noted between @entity876 and any other gene expression. @entity986 expression was observed in 12 (8.3%) out of all cases. A negative correlation was recognized between @entity986 and @entity4910 expression (P=0.0004). @entity996 expression was observed in 130 (90.3%) out of all cases, whereas @entity996 expression was not observed in 11 out of the 12 @entity1 with @entity986 -positive @entity5 . A negative correlation was also found between @entity986 and @entity996 (P < 0.0001). A positive correlation was noted between @entity996 and @entity4910 expression (P=0.0009). The cumulative survival rate of @entity1 without @entity996 expression was significantly lower than that of @entity1 with positive expression (P=0.003). In the multivariate survival analysis, @entity996 expression was an independent prognostic factor. In 98% of all @entity1 with @entity418 , impairment of the G1 checkpoint is due to a loss of function by @entity986 , @entity996 or @entity4910 , which showed a negative correlation in each factor. In addition, aberrant expression of @entity996 is useful as a prognostic factor in @entity418 .
