Neurotrophins and B-cell XXXX .

@entity981 @entity5 @entity13714 @entity2936 @entity2109 @entity2251 @entity1582 @entity1892 @entity2252 @entity2250
UNASSIGNED: Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro- and mature forms, and can act in an autocrine or paracrine fashion. The @entity13714 and Trk receptors can elicit signalling in response to the presence or absence of their corresponding @entity2252 ligands. This signalling, along with @entity2252 and receptor expression, varies between different cell types. Neurotrophins and their receptors have been shown to be expressed by and elicit signalling in B lymphocytes. In general, most neurotrophins are expressed by activated B-cells and memory B-cells. Likewise, the TrkB95 receptor is seen on activated B-cells, while @entity2250 and @entity2251 ( @entity13714 ) are expressed by both resting and active B-cells as well as memory B-cells. Nerve growth factor stimulates B-cell proliferation, memory B-cell survival, antibody production and @entity2936 expression. @entity2252 is involved in B-cell maturation in the bone marrow through TrkB95. Overall neurotrophins and their receptors have been shown to be involved in B-cell proliferation, development, differentiation, antibody secretion and survival. As well as expression and activity in healthy B-cells, the neurotrophins and their receptors can contribute to B-cell @entity5 including @entity981 , diffuse large @entity1892 , @entity2109 and @entity1582 . They are involved in B-cell malignancy survival and potentially in drug resistance.
