[Effect of @entity7651 on signal transduction and activating transcription factor expression in XXXX @entity1 ].

@entity1 @entity650 @entity8850 @entity294 @entity7651 @entity31 @entity14283 @entity688 @entity379 @entity7116 @entity3646 @entity21149 @entity1744
OBJECTIVE: To explore the intervention of @entity7651 on signal transduction and activating transcription factor expression of @entity31 ( @entity31 ) @entity1 . METHODS: Recruited were @entity31 @entity1 at Outpatient Department of @entity21149 , Inpatient Department of @entity21149 , Center for Digestive Endoscopy of College City Branch, Guangdong Provincial Hospital of Traditional Chinese Medicine, and Southern Hospital affiliated to Southern Medical University from June 2010 to January 2011. They were assigned to the @entity31 group (33 cases) and the @entity294 -predominant @entity1744 ( @entity1744 ) group (30 cases). Another 30 healthy subjects were recruited as a healthy control group. Peripheral blood mononuclear cells (PBMCs) in vitro intervened by different concentrations @entity7651 were taken from @entity31 @entity1 . @entity14283 gene expressions in vitro intervened by different concentrations @entity7651 were detected using Q-PCR. Expressions of @entity7116 ( @entity7116 ) , @entity8850 , phosphorylated- @entity7116 (p- @entity7116 ), and p- @entity8850 were detected using Western blot. Serum levels of @entity379 , @entity3646 , @entity650 , and @entity688 were measured by ELISA. Effects of different concentrations @entity7651 on expressions of PBMCs, and levels of @entity379 , @entity3646 , @entity688 of @entity31 @entity1 were also detected. RESULTS: Compared with the negative control group, 40   mol @entity7651 obviously decreased @entity14283 gene expression of @entity31 @entity1 (P <0. 01). Compared with the healthy control group and the @entity1744 group, p- @entity7116 / @entity7116 ratios increased, p- @entity8850 / @entity8850 ratios decreased, levels of @entity379 , @entity3646 , @entity688 all increased in the US group (all P <0. 05). Compared with the negative control, 5 and 10   mol @entity7651 groups, 20 and 40 moL @entity7651 obviously decreased p- @entity7116 / @entity7116 ratios (all P <0. 05); 20 and 40   moL @entity7651 obviously increased p- @entity8850 / @entity8850 ratios (all P <0. 05); 20 and 40   moL @entity7651 obviously lowered levels of @entity379 and @entity3646 , and elevated @entity688 levels (all P <0. 05). CONCLUSION: 40   moL @entity7651 could in vitro inhibit p- @entity7116 / @entity7116 ratios, adjust p- @entity8850 / @entity8850 ratios and related cytokines, thereby balancing the immunity and relieving inflammatory reactions of @entity31 .
