Effects of prolonged treatment with compound 48/80 on the gastric mucosa and mast cells in the XXXX .

@entity1819 @entity4478 @entity750 @entity112 @entity35
Effects of prolonged administration of compound 48/80 (48/80) on the gastric mucosa, @entity750 and @entity112 levels in serum, and mast cells of @entity35 were studied. Daily administration of 48/80 (0.75 mg/kg, i.p.) for 2 or 4 days produced widespread @entity1819 . Further administration of the agent for up to 12 days did not aggravate the lesions which had developed in the early period of administration of the drug. There were only a few visible lesions and numerous healed ones. Almost the same phenomenon was observed with the daily administration of @entity750 plus @entity112 (10 mg/kg each, i.p.) for 2 to 12 days. While 48/80 given for 2 or 4 days increased @entity750 and @entity112 levels in serum, it induced no appreciable increase of these @entity4478 after 8 or 12 days of treatment. @entity750 and @entity112 levels in peritoneal mast cells significantly decreased after the treatment with 48/80 over a 4 day period. The decrease in @entity1819 after prolonged treatment with 48/80 is due to both the depletion of @entity750 and @entity112 from mast cells and an increased resistance of the gastric mucosa with healed lesions.
