[Progressive XXXX . Case report].

@entity1 @entity1610 @entity309 @entity179 @entity74 @entity158 @entity717 @entity44747 @entity792 @entity528 @entity2693
We present the case of a 17-year-old @entity1 suffering from progressive @entity1610 from whom 2 total hip prostheses and 2 total knee prostheses were necessary. We have to do with a recessive @entity74 characterized by a lysis of the articular cartilage. This leads to an early @entity528 . The clinic is mainly characterized by various complaints such as @entity158 , @entity2693 , limitation or swelling causing a significant @entity717 from childhood. The first joints affected are situated in the hands, later followed by the hips, elbows and knees. The X-rays show severe, multifocal @entity179 which are unusual for the age. The genetic mutation concerns the @entity44747 gene actively expressed by articular chondrocytes and located on chromosome 6. The differential diagnosis is done with a series of @entity74 in @entity1 and @entity792 . We mainly retain the @entity309 . A symptomatic medical treatment can be undertaken first. However, given the evolving nature of the pathology, a joint replacement surgery is needed once the @entity1 's growth is finished (second decade of life).
