Gradual reintroduction of XXXX reduces reperfusion injury in cat stomach.

@entity548 @entity63 @entity190 @entity26 @entity3137 @entity4095
Recent studies have shown that @entity26 -derived free radicals are responsible for a major portion of @entity63 -reperfusion injury in the stomach. The @entity26 radicals are produced during reperfusion when @entity26 delivery to the tissue increases. In the present study we investigate the effect on @entity3137 of regulating the rate of reintroduction of @entity26 to the stomach after @entity63 . Local @entity63 was achieved by reducing celiac artery pressure to 30 mm Hg for 1 h. @entity63 was assessed by measuring the loss of 51Cr-labeled red blood cells across the gastric mucosa. Mucosal @entity190 was negligible before and during the @entity63 period but increased to 0.178 ml.min.-1.100 g-1 during reperfusion. When blood flow to the stomach was gradually returned to normal after @entity63 by increasing celiac artery pressure by 10 mmHg every 10 min, the mucosal @entity190 was reduced to 0.013 ml.min.-1.100 g-1. If the stomach was vascularly perfused with low @entity4095 (34 mmHg) blood for 1 h after @entity63 before being returned to normal arterial perfusion, the mucosal @entity190 was also reduced to 0.063 ml.min.-1.100 g-1. When the stomach was made hypoxemic for 1 h rather than ischemic by perfusing the vasculature with low @entity4095 (29 mmHg) blood then reperfused with normoxic blood, there was @entity548 (0.014 ml.min.-1.100 g-1). The data indicate that gastric @entity548 after @entity63 is reduced if the tissue is returned slowly to a normal @entity4095 . These findings support the concept that reperfusion injury is due largely to the production of @entity26 radicals.(ABSTRACT TRUNCATED AT 250 WORDS)
