XXXX , @entity286 , and mammographic density: a population-based study.

@entity1 @entity286 @entity0 @entity167 @entity14220
@entity14220 ( @entity14220 ), or the proportion of the breast with respect to its overall area that is composed of dense tissue, is a strong risk factor for @entity0 . Studies support a positive association of mammographic density and @entity167 drinking. This was a cross-sectional multicenter study based on 3584 @entity1 , aged 45-68 years, recruited from seven screening centers within the Spanish @entity0 screening program network. The association between @entity14220 , @entity167 consumption and @entity286 use was evaluated by using ordinal logistic models with random center-specific intercepts. We found a weak positive association between current @entity167 intake and higher @entity14220 , with current @entity167 consumption increasing the odds of high @entity14220 by 13% (OR = 1.13; 95% CI 0.99-1.28) and high daily grams of @entity167 being positively associated with increased @entity14220 (P for trend = 0.045). There were no statistically significant differences in @entity14220 between smokers and non-smokers. Nevertheless, increased number of daily cigarettes and increased number of accumulated lifetime cigarettes were negatively associated with high @entity14220 (P for trend 0.017 and 0.021). The effect of @entity167 on @entity14220 was modified by menopausal status and @entity286 smoking: whereas, @entity167 consumption and daily grams of @entity167 were positively associated with higher @entity14220 in postmenopausal @entity1 and in @entity1 who were not currently smoking, @entity167 consumption had no effect on @entity14220 in premenopausal @entity1 and current smokers. Our results support an association between recent @entity167 consumption and high @entity14220 , characterized by a modest increase in risk at low levels of current consumption and a decrease in risk among heavier drinkers. Our study also shows how the effects of @entity167 in the breast can be modified by other factors, such as smoking.
