Association between the @entity18957 gene and overweight in Japanese XXXX and adolescents.

@entity1 @entity18957 @entity18956 @entity28 @entity73016 @entity73017
BACKGROUND: The association between the fat mass- and @entity28 -associated ( @entity18957 ) gene and a predisposition to @entity28 is inconsistent in adult Asian populations. We investigated the association of the @entity18957 gene with weight status in Japanese @entity1 and adolescents. DESIGN/SETTING: Nested case-control study and 3-yr longitudinal study - In the Shunan @entity1 Cohort Study, fifth and eighth grade students attending all schools of Shunan completed the questionnaires. Overweight, including @entity28 , was defined as a percentage of overweight of 20% or in accordance with the International Obesity Task Force. We recruited 133 obese subjects and randomly selected controls from the 2006 cohort. We genotyped three @entity18957 single nucleotide polymorphisms (SNPs): @entity73016 , @entity18956 , and @entity73017 . RESULTS: The three genotyped SNPs were in tight linkage disequilibrium, with the exception of one case. The minor SNP allele of @entity73016 conferred a predisposition to @entity28 , and its odds ratio was 2.2 [95% confidence interval (CI), 1.5-3.4] in the additive model and 2.7 (95% CI, 1.6-4.4) in the dominant model (p < 0.001). Although blood parameters and some lifestyle behaviors were significantly different between the cases and controls (p < 0.01), these traits were not significantly different among the genotypes. In addition, we did not find an association between the genotypes and body mass index change during the 3 yr. CONCLUSION: The @entity18957 gene is associated with the early onset of overweight in the Japanese population as well as in European populations. The results suggest that @entity28 -related risk factors in fifth and eighth graders appear because of their overweight status.
