Prognostic value of serum LP-PLA2 and hs-CRP in unstable XXXX .

@entity9115 @entity95 @entity112 @entity2834 @entity1317 @entity731 @entity165
To evaluate the prognostic value of LP-PLA2 and hs-CRP to the stability of @entity731 . Forty-eight New Zealand White @entity95 were randomly divided into control group, stable plaque group, P53 group, and P53 + drug group. @entity95 in the control group were fed a regular diet. @entity95 in stable plaque group, P53 group, and P53 + drug group underwent balloon-induced @entity1317 and then were fed a diet of 1% @entity165 . Then the @entity95 in the P53 group and P53 + drug group underwent Ad5- @entity2834 P53 transfection in the 10th week; The P53 + drug group underwent pharmacologic triggering with @entity9115 venom (RVV) and @entity112 in 24 h and 48 h before euthanized. Intravascular ultrasound (IVUS) was used before sacrificing of the animal. In the 0 week and 12th week, @entity95 underwent fast blood collection from the medium-sized artery of the ears, and the serum LP-PLA2 and hs-CRP level was determined. The animal altherosclerotic (AS) model was successfully gained and the rules of serum LP-PLA2 and hs-CRP level in instable plaque were discovered: serum LP-PLA2 in P53 group and P53 + drug group were significantly different from the control group and the stable group, while hs-CRP failed to differ between the control group and the stable group and succeeded in different degrees of unstable plague. The relationship analysis of serum and IVUS results revealed LP-PLA2 might predict an instability of plaque. Combining serum Lp-PLA2 and hs-CRP has higher specificity in predicting the vulnerability of the plaque.
