17 beta-estradiol levels in blood and cerebrospinal fluid after ocular and nasal administration in XXXX and female @entity2608 ( @entity2608 ).

@entity1 @entity2608 @entity1815 @entity53
@entity53 was applied ocularly to menstruating and postmenopausal @entity1 . The absorption by blood was measured. A rapid increase of both @entity53 and @entity1815 was seen with higher plasma levels in the menstruating group, possibly due to a better conjunctival circulation. Twenty-one @entity2608 were given @entity53 suspension or solution ocularly or nasally. The absorption by blood and cerebrospinal fluid was measured and compared to intravenous injection of 0.5 mg @entity53 . @entity53 increased in plasma after 1'. Maxima were reached at 15'. @entity53 solution gave higher plasma levels than @entity53 suspension. At 5' they amounted to the levels found after i.v. injection. The @entity53 levels in cerebrospinal fluid never exceeded the corresponding plasma levels and were generally low. The increase in cerebrospinal fluid was thought to be secondary to the raised plasma levels.
