The phenomenon of XXXX : redefining the virtues of promiscuity.

@entity5 @entity4025 @entity19971 @entity105
@entity5 chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of @entity105 . With support provided by the National @entity5 Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. The typical approach involves identifying active crude substances such as extracts derived from terrestrial plants or marine organisms, utilizing in vitro bioassay systems, followed by the isolation of pure active components. As part of this project, an extract obtained from a nonedible Peruvian legume, Cassia quinquangulata Rich. (Leguminosae), was evaluated and found to be active as an inhibitor of cyclooxygenase. The active component was identified as @entity4025 . Surprisingly broad spectrum activity was observed, indicative of potential to inhibit @entity105 at the stages of initiation, promotion, and progression. This discovery has led to many additional research efforts. There are now around 3,500 papers concerning some aspect of @entity4025 action, yet the molecule is unusually promiscuous and specific mechanisms remain elusive. Considering the structural simplicity of this @entity19971 , the intensity of interest is phenomenal.
