Transcription factors XXXX and @entity19986 regulate development of airway remodeling.

@entity32 @entity82 @entity121 @entity19986 @entity639 @entity19 @entity565 @entity1373 @entity61 @entity19985 @entity630
RATIONALE: Airway remodeling is an important feature of chronic @entity565 that causes irreversible airflow obstruction. Although @entity565 is considered to be a @entity61 disease, the role of @entity19985 and @entity19986 , the key transcription factors for differentiation toward @entity630 and @entity61 cells, in the pathogenesis of airway remodeling is poorly understood. OBJECTIVES: We therefore examined the effects of @entity19986 or @entity19985 induction of @entity630 / @entity61 bias on the development of airway remodeling in @entity19 . METHODS: The development of airway remodeling after repeated allergen challenges was analyzed using @entity19 overexpressing either @entity19986 or @entity19985 . MAIN RESULTS: The degrees of subepithelial @entity82 and airway smooth @entity121 after repeated allergen exposure were significantly enhanced in @entity19 overexpressing @entity19986 , compared with wild-type @entity19 . Allergen-induced @entity1373 and mucus hypersecretion were significantly lower in @entity19 overexpressing @entity19985 than in wild-type @entity19 . Eosinophilic airway inflammation increased in @entity19 overexpressing @entity19986 , but decreased in @entity19 overexpressing @entity19985 after repeated allergen exposure. Cytokine analysis revealed that the @entity630 / @entity61 cytokine balance shifted to @entity61 in lung homogenates and lung T cells of @entity19 overexpressing @entity19986 , whereas this balance shifted to @entity630 in those of @entity19 overexpressing @entity19985 after allergen exposure. Lung transforming growth factor-beta and @entity639 levels were associated with the degree of subepithelial @entity82 and @entity32 , respectively. CONCLUSIONS: Overall, the results indicate that development of airway remodeling is regulated by the lung @entity630 / @entity61 bias induced by @entity19986 and @entity19985 .
