Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of XXXX .

@entity2997 @entity5521 @entity95 @entity5333 @entity12108 @entity3897 @entity1063 @entity5402
Isolated circulatory or longitudinally oriented strips from anterior or posterior @entity95 bladder base were tested for responsiveness to agonists and sensitivity of field stimulation-induced responses to antagonists. Results were compared to the regional distribution of adrenergic and cholinergic nerves determined histochemically. Greater @entity1063 -induced responses in posterior than in anterior strips reflect denser noradrenergic innervation in posterior base. Longitudinal strips responded better to @entity5402 than circular strips, but no orientation-related differences in cholinergic nerve density or muscle mass were noted. Field stimulation-induced contractions were largely resistant to @entity5333 (0.03 microM) and @entity2997 (100 microM) and slightly reduced by @entity5521 (2.6 microM). @entity3897 (0.4 microM) reduced maximum responses by 25 to 75%. The resistance to @entity2997 suggests that the ineffectiveness of @entity5333 is not due solely to atypical post synaptic receptors. Inaccessibility of the synaptic cleft to @entity2997 is unlikely because the @entity12108 , which possesses close contacts, was sensitive to @entity2997 . Neurotransmission in bladder base may be partially noradrenergic, noncholinergic in nature. A question arises concerning the functional significance of the noradrenergic nerves in bladder base.
