XXXX and @entity413 differentially increased extracellular @entity1130 in the @entity35 brain.

@entity1522 @entity35 @entity535 @entity5581 @entity1735 @entity2339 @entity750 @entity1130 @entity413
To reveal the role of serotonergic neurons in the regulation of feeding, the levels of @entity1130 ( @entity5581 ), a metabolite of @entity750 , in the striatum and the @entity2339 were continuously monitored by an in vivo microdialysis technique. Intake of 20% casein diet did not induce significant changes in the @entity5581 level in these regions. When @entity35 were fed on 5% casein diet (83.5% @entity1735 diet) for 2 h, the level of @entity5581 in the striatum gradually increased and reached a maximum (226 +/- 44% of basal level, M +/- SEM, n = 7) at 4 h after stopping the diet. In the medial @entity2339 , its level also increased to 183 +/- 19% (n = 10) at 2 h after starting the diet. On the other hand, a 60% casein diet increased the level of @entity5581 in the lateral @entity2339 to 138 +/- 19% (n = 10) at 2 h after starting the diet. The intravenous infusion of each of these nutrients, @entity413 , @entity535 mixture or lipid, produced more rapid elevation of the @entity5581 level than oral intake of the diets. When @entity35 were infused with @entity413 , its level in the striatum continued to be elevated. In the medial @entity2339 , @entity413 infusion increased @entity5581 to the maximum (189 +/- 38%, n = 7) at 4 h after starting infusion. In contrast, serotonergic neurons in the lateral @entity2339 seemed to respond only to infusion of the @entity535 mixture, and the level of @entity5581 reached 163 +/- 14% (n = 5) of the basal level at 1 h after starting the infusion. These results suggest that rapid elevation of @entity413 or @entity1522 may independently stimulate @entity750 metabolism in these brain areas, participating in the feedback regulation of nutrient intake.
