The bugeye mutant @entity3392 exhibits XXXX that arise with the onset of an @entity2194 .

@entity2194 @entity227 @entity2479 @entity726 @entity51 @entity2790 @entity164 @entity3392
PURPOSE: The bugeye mutant has an @entity2194 , presumably because of @entity2790 . Since @entity2790 is a significant risk factor for @entity726 , the bugeye @entity3392 mutant may be a model organism for the disease. METHODS: The optomotor response (OMR) was used to assess visual responsiveness in both larval and adult @entity3392 . Electroretinograms (ERGs) were recorded to measure outer retinal function, and histologic analyses were performed on @entity164 and mutant eyes. RESULTS: At 5 days old, bugeye mutants have an OMR, ERGs, and retinal morphology indistinguishable from those of @entity164 ( @entity164 ) animals. By 2 months of age, bugeye mutants begin to develop an @entity2194 . At 3 months, some mutants show deficits in the OMR assay, including lower contrast sensitivity. The data suggest that there is a correlation between the size of the enlarged eye and the degree of @entity51 . Histologic analysis of the bugeye mutant retina revealed @entity2479 cell densities by 3 months. By 5 months, the mutant's ERG b-wave had smaller amplitudes and longer latencies at brighter light intensities than those of the @entity164 fish. CONCLUSION: After phenotypic onset at 3 months, the bugeye mutants begin to develop @entity227 . At 3 months, bugeye mutants exhibit a decrease in retinal cell densities and by 5 months, they show diminished outer retinal function. In summary, the bugeye mutant provides a means of studying @entity726 -associated phenotypes in the @entity3392 .
