[THE COMPARISON OF RESULTS OF DETECTION OF MINIMAL RESIDUAL DISEASE IN PERIPHERAL BLOOD AND MARROW IN XXXX OF THE FIRST YEAR OF LIFE WITH ACUTE LYMPHOBLASTIC LEUCOSIS].

@entity1 @entity1861 @entity981 @entity66 @entity5 @entity11626 @entity1503
The occurrence of minimal @entity66 is an important prognostic factor under @entity981 in @entity1 and adults. In overwhelming majority of research studies bone marrow is used to detect minimal @entity66 . The comparative characteristic of detection of minimal @entity1503 and bone marrow was carried out. The prognostic role of occurrence of minimal @entity1503 and bone marrow under therapy according protocol @entity11626 -Baby was evaluated. The analysis embraced 142 pair samples from 53 @entity1 with @entity981 and various displacements of gene @entity11626 younger than 365 days. The minimal @entity66 was detected by force of identification of chimeric transcripts using polymerase chain reaction in real-time mode in 7 sequential points of observation established by protocol of therapy. The comparability of results of qualitative detection of minimal @entity66 in bone marrow and peripheral blood amounted to 84.5%. At that, in all 22 (15.5%) discordant samples minimal @entity66 was detected only in bone marrow. Despite of high level of comparability of results of detection of minimal @entity1503 and bone marrow the occurrence of minimal @entity1503 at various stages of therapy demonstrated no independent prognostic significance. The established differences had no relationship with sensitivity of method determined by value of absolute expression of gene @entity1861 . Most likely, these differences reflected real distribution of @entity5 cells. The results of study demonstrated that application of peripheral blood instead of bone marrow for monitoring of minimal @entity66 under @entity981 in @entity1 of first year of life is inappropriate. At the same time, retention of minimal @entity66 in TH4 in bone marrow was an independent and prognostic unfavorable factor under therapy of @entity981 of @entity1 of first year of life according protocol @entity11626 -Baby (OO=7.326, confidence interval 2.378-22.565).
