The histomorphometry of bone in XXXX : preservation of cancellous bone structure.

@entity1 @entity459 @entity2741 @entity79 @entity803
To evaluate the effects of @entity459 ( @entity459 ) on bone mass and structure, we have studied the iliac crest biopsies of 27 @entity1 , 10 males (28-68 yr old) and 17 females (26-72 yr old) with mild @entity459 after in vivo @entity803 labeling. All @entity1 had mild @entity2741 in the absence of any other cause and elevated levels of PTH without radiological evidence of @entity79 . Static parameters of bone turnover (osteoid surface, osteoid volume, and eroded surface) were elevated in both @entity1 and @entity1 compared to normal values; the midmolecule RIA for PTH (PTHMM) was positively correlated with osteoid surface (r = 0.44; P less than 0.025) and eroded surface (r = 0.58; P less than 0.005). Dynamic parameters of bone turnover (mineralizing surface, expressed as double plus half single labeled surface, and bone formation rate at tissue level) were elevated compared to normal values; PTHMM was positively correlated with double plus half single labeled surfaces (r = 0.33; P less than 0.05) and with bone formation rate at the tissue level (r = 0.37; P less than 0.05). The mineral apposition rate was within the limits of normal values and positively correlated with PTHMM (r = 0.34; P less than 0.05). Histomorphometric parameters of bone structure [cancellous bone volume (BV/TV), trabecular thickness (Tb. Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), cortical thickness (Ct.Th), and total bone density (TBD)] were compared to those in 20 autopsy control subjects, 12 @entity1 (33-60 yr old) and 8 @entity1 (27-75 yr old). BV/TV and Tb.N were significantly higher in @entity459 @entity1 than controls (P less than 0.02 and P less than 0.001, respectively). Tb.Sp was significantly lower in @entity459 @entity1 than controls (P less than 0.001), whereas Tb.Th was not significantly different between @entity459 @entity1 and controls. Ct.Th was significantly lower in @entity459 @entity1 than in controls (P less than 0.001), whereas TBD was not significantly different between the two groups. BV/TV was negatively correlated with age in both controls and @entity459 @entity1 . Tb.N showed a negative correlation and Tb.Sp a positive correlation with age in controls (r = -0.47; P less than 0.05 and r = 0.52; P less than 0.02, respectively), but they were not significantly dependent on age in @entity459 @entity1 . Tb.Th, while showing no significant age-related change in controls, was negatively correlated with age in @entity459 @entity1 (r = -0.42; P less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)
