PC:PS liposomes induce a recruitment of neutrophils and the release of XXXX in the lungs of @entity19 sensitized with Saccharopolyspora rectivirgula.

@entity55 @entity19 @entity619 @entity19264 @entity637
The aim of this study was to verify the effect of nasally instilled liposomes (L) or @entity619 -containing L (Ldexa) on normal or inflamed lung tissue. Three groups of @entity19 were studied. Group I was given saline instillations for 3 weeks prior to the instillation with liposomes. In @entity55 was induced by repeated instillations of Saccharopolyspora rectivirgula before the instillation of liposomes (group II) or liposomes containing @entity619 (group III). Animals from all groups were killed at regular time intervals for up to 48 h after the instillation of liposomes. The total cell count in bronchoalveolar lavage fluid did not differ significantly between groups I and II. However, in group III it decreased rapidly from 6.2 to 2.8 x 10(5) cells @entity19264 within 2 h. Differential counts did not change in group I, but in group II a transient neutrophilia was observed 180 min after the instillation of liposomes. In group III, the instillation of @entity619 -containing liposomes depleted all neutrophils and lymphocytes after 4 h. No @entity637 was found in samples of lavage fluid from any of the groups at time 0. In group I, liposomes induced the production of 0.03 ng @entity19264 of @entity637 in the 1 h sample only. In group II, @entity637 peaked to 1 ng @entity19264 at 1 h and had decreased to 0.35 ng @entity19264 by 3 h. In group III, @entity637 peaked at 1 h, but only reached a level of 0.1 ng @entity19264 .(ABSTRACT TRUNCATED AT 250 WORDS)
