Diagnosis of XXXX using quantitative cultures from sonicated antibiotics-loaded spacers: implications for the clinical outcome.

@entity4625 @entity1 @entity281
UNASSIGNED: Recent studies showed that a positive microbiological result from sonication of the @entity4625 spacer was associated with poor outcome of @entity1 , but no quantitative analysis has yet been performed. For this purpose, a prospective analysis of 50 spacers (46 @entity1 ) was performed. All spacers were processed according to a previously described protocol, including centrifugation and quantitative culture. Clinical data and outcome were also analysed. A statistical relationship between the results of the cultures and the outcome of the @entity1 was assessed. Sixteen @entity1 were diagnosed with @entity281 . Thirteen out of 50 spacers gave a positive culture. Nine of 13 presented with growth of an organism not isolated in the first-stage cultures, and in 7 out of 13 the organisms count was high (>10,000  CFU/ml). We have detected a significant statistical relationship between poor outcome and positive cultures, high colony counts, isolation of different organisms, positive periprosthetic cultures and @entity281 . The detection in a sonicated, antibiotic-loaded @entity4625 spacer of organisms other than those isolated in the first surgical samples or high colony counts of any organisms is diagnostic with regard to @entity281 .
