A randomized pilot study of dietary treatments for XXXX in adolescents.

@entity1 @entity3610 @entity251 @entity28 @entity1735 @entity258
BACKGROUND: Evidence is lacking to recommend one diet over another when treating @entity3610 ( @entity3610 ). OBJECTIVES: To obtain preliminary data, comparing the impact of a low-glycaemic load (LGL) vs. @entity258 ( @entity258 ) diet on biochemical hyperandrogenism in overweight and @entity28 adolescents with @entity3610 . To ascertain feasibility of recruiting study @entity1 , in partnership with an adolescent clinic, and implementing dietary interventions. METHODS: Randomized controlled trial of 19 overweight and @entity28 adolescents with @entity3610 and not using hormonal contraceptives (HCs). Interventions comprised nutrition education, dietary counselling and cooking workshops to foster adherence to a LGL (45% @entity1735 , 35% fat, 20% protein) or @entity258 (55% @entity1735 , 25% fat, 20% protein) diet over 6 months. Serum bioavailable @entity251 was the primary outcome. RESULTS: Sixteen (LGL, n   =   7; @entity258 , n   =   9) @entity1 completed the study. Body fat percentage decreased (P   <   0.05) in response to the interventions, with no difference between the LGL and @entity258 groups (-1.2% vs. -2.2%; P   =   0.16). Bioavailable @entity251 did not change for either group (-0.4 vs. -1.8   ng   dL(-1) ; P   =   0.35). Regarding feasibility, recruiting adolescents posed a challenge, and use of HCs was a main reason for ineligibility. @entity1 attended 5.9 of 6 in- @entity1 visits and 2.6 of 3 cooking workshops, completed 4.9 of 6 telephone counselling calls, and reported high satisfaction with the diets and cooking workshops (>= 8 on a 10-cm scale). CONCLUSIONS: Dietary interventions were beneficial for weight control but did not attenuate biochemical hyperandrogenism. Innovative strategies are needed to recruit adolescents for studies aimed at assessing independent effects of diet on features of @entity3610 .
