High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune XXXX .

@entity1 @entity991 @entity409 @entity31 @entity99 @entity792 @entity775
BACKGROUND/AIMS: @entity775 ( @entity775 ), an unresolving @entity409 characterized by periportal @entity99 and presence of serum autoantibodies, is distinguished by smooth muscle antibody and/or antinuclear antibody seropositivity. Type-2 @entity775 is characterized by antibodies to liver/kidney microsome type-1. Antineutrophil cytoplasmic antibodies (ANCAs) are highly specific for @entity31 , @entity991 , and, in this report, type-1 @entity775 determined by positive enzyme-linked immunosorbent assay confirmed by perinuclear indirect immunofluorescence staining. The studies described characterize the frequency and nature of ANCA in severe type-1 @entity775 @entity1 and define @entity775 -ANCA specificity and diagnostic significance. METHODS: One hundred four @entity1 , characterized by clinical, immunoserological, virological, histological, and antigenic criteria, were studied. ANCA expression was assayed by enzyme-linked immunosorbent assay. RESULTS: High-titer ANCA is present in 96% of @entity1 with type-1 @entity775 with 92% showing a perinuclear staining pattern (pANCA). Whereas many @entity1 were seropositive for antinuclear antibodies, the titer of ANCA did not correlate with the titer of antinuclear antibodies. ANCA expression did not correlate with the presence or absence of other @entity792 . Finally, 80% of @entity1 with @entity775 examined expressed only immunoglobulin G1 pANCA contrasting with the 33% of @entity1 with PSC with pANCA subclass specificity. CONCLUSIONS: The presence of ANCA seems to be an independent and selective marker for type-1 @entity775 .
