Tea XXXX protect against irradiation-induced injury in submandibular glands' cells: a preliminary study.

@entity12809 @entity1885 @entity1161 @entity1372 @entity1977 @entity35 @entity6398 @entity9342
AIM: To study the protective effect of tea @entity6398 (TPs) on submandibular glands affected by @entity1161 . METHODS: Sixty @entity35 were randomly divided into radiation group (R-group, N = 30) and TP-pre-treated-radiation group (TPR-group, N = 30). The @entity35 were intragastrically administered with TP or normal @entity1372 from 14 days before radiation, continuously daily, until the experiment. All the @entity35 in both groups were irradiated with a single exposure dose of 15 Gy gamma rays that were delivered to the head and neck areas. Ten @entity35 of each group were anatomised on the 3rd, 6th and 30th day after irradiation, respectively. The submandibular glands of the @entity35 were removed for the study. The morphologic changes of the submandibular glands were observed by transmission electron microscopy (TEM). The @entity12809 ( @entity12809 )-mediated @entity9342 ( @entity1977 )- @entity1885 nick-end labelling (TUNEL) method was used to detect apoptosis of the submandibular glands' cells. RESULTS: Electron microscope observation of the submandibular glands showed that the lesions of the TPR-group were mild. Change in apoptosis of the cells was not obvious compared with the R-group. The cell apotosis was typical after irradiation in the R-group. Apoptosis index that was detected in the cells of submandibular glands of the TPR-group was statistically significantly decreased compared with the R-group (P < 0.01) on the 3rd, 6th and 30th day after irradiation. CONCLUSION: TP could protect submandibular glands from @entity1161 , and the protection mechanism may be realised by anti-apoptosis.
