Histologic and biochemical correlates of left ventricular chamber dynamics in XXXX .

@entity1 @entity82 @entity1391 @entity15071 @entity855
To investigate the relation between left ventricular chamber dynamics in @entity1 and the quantitative analysis of the histologic and biochemical characteristics of left ventricular endomyocardial biopsy material, 15 @entity1 with a wide range of ventricular function were studied. The pressure-volume relation was determined using simultaneous gated radionuclide angiography, echocardiography and micromanometer pressure. The derived chamber dynamics were then compared with quantitative histologic data (percent @entity82 and cell diameter) and @entity855 content measurements obtained from the left ventricular biopsy specimen obtained at the time of the pressure-volume studies. The measures of systolic function correlated linearly with high energy @entity1391 content. The @entity855 /protein ratio (nanomoles) was shown to parallel ejection fraction (r = 0.81), peak ejection rate (r = -0.73) and peak positive maximal rate of rise in left ventricular pressure (dP/dt) (r = 0.79). No correlation was observed between these variables and the percent @entity82 or cell diameter. Variable results were found in comparing the diastolic properties of the left ventricle with the biopsy data. In general, the high energy @entity1391 content correlated with measures of active relaxation, but not with the passive filling characteristics of the left ventricle. The @entity855 /protein ratio was linearly related to peak negative dP/dt (r = -0.74) and the peak filling rate (r = 0.76) but correlated less well with other measures of active and passive @entity15071 . No correlation was found between any diastolic variable and the percent @entity82 or cell diameter.(ABSTRACT TRUNCATED AT 250 WORDS)
