[Nasal XXXX : quantification of the eosinophil and granulocyte infiltrates. Anatomo-clinical correlations].

@entity1 @entity66 @entity565 @entity117 @entity1195 @entity5824 @entity134 @entity1412
OBJECTIVE: Prospective study designed to count the number of granulocytic cells and eosinophils in nasal polyp tissue removed during ethmoidectomy and to look for anatomical correlations. METHODS: Bilateral ethmoidectomy with a postoperative local @entity134 treatment was performed in 40 @entity1 with @entity1412 . Immunolabeling of the operative specimen using common leukocyte antigen ( @entity1195 ) and granulocytes associated antigen ( @entity5824 ) and quantification of the granulocyte infiltrate by image and manual counting of eosinophils with the mean of micro-reticule, were performed. The results were compared to those of 10 healthy subjects. An endoscopy of the postoperative cavities was performed one year after surgery to assess the local results. RESULTS: The granulocyte and eosinophil infiltrates were significantly more important in the operated @entity1 compared to the healthy population (p<10(- 4)). A "moderate" granulocytic infiltration (G -) was found in 11 @entity1 out of 40 (27.5%). Among them, 9 @entity1 showed less than 30% eosinophils (mean 16.2% +/- 2%). "Severe" granulocytic infiltrate (G +) was found in 29 @entity1 out of 40 (72.5%). Among them, 25 @entity1 showed more than 30% eosinophils (mean 48.8% +/- 2%). Most of the @entity1 with G + type infiltrate suffered from @entity66 . One year after surgery, 17 out of 29 G + @entity1 had no @entity1412 recurrence, 12 out of 29 G + @entity1 had a recurrence. However, 12 out of 15 @entity1 with recurrent @entity1412 had G + type infiltrate. CONCLUSIONS: Granulocyte and eosinophil infiltration cannot be considered as a prognostic factor for recurrence at the time of surgery. A severe granulocyte and eosinophil infiltration is a typical feature of @entity1412 , particularly in @entity1 with @entity565 and/or in the @entity117 triad.
