Role of the sympathetic nervous system in the maintenance of @entity101 in XXXX harboring @entity1911 .

@entity1 @entity3160 @entity101 @entity35 @entity1911 @entity935 @entity3159 @entity14523 @entity1510 @entity1338 @entity2661 @entity1063
@entity101 due to @entity1911 is generally considered to be a straightforward, direct consequence of the elevated concentrations of circulating @entity2661 . However, @entity1338 , a centrally acting antihypertensive drug, has been reported to lower blood pressure in @entity1 with @entity1911 , suggesting the possibility that the sympathetic nervous system is involved in the maintenance of @entity101 in this disease. We have investigated this possibility in New England Deaconess Hospital @entity35 harboring a transplantable @entity1911 that secretes @entity1063 and @entity935 . Both @entity1338 and @entity14523 , a ganglionic blocker, markedly decreased blood pressure in tumor-bearing @entity35 . However, in other @entity35 made acutely @entity101 with a @entity1063 infusion, neither @entity1338 nor @entity14523 decreased blood pressure. This result indicates that in an acute model of @entity101 , where baroreflex mechanisms have likely withdrawn sympathetic tone, neither @entity1338 nor @entity14523 had nonspecific antihypertensive effects. A central nervous system site of action for the antihypertensive effect of @entity1338 in the @entity35 harboring @entity1911 was suggested by the observation that the opiate antagonist @entity1510 both reversed and prevented @entity1338 's effect on blood pressure. @entity3159 and @entity3160 were utilized to determine the respective contributions of alpha-1 and alpha-2 adrenergic receptors in the maintenance of @entity101 in @entity35 harboring @entity1911 . Both drugs markedly lowered blood pressure in these @entity35 . Our data suggest that both the sympathetic nervous system and circulating @entity2661 are involved in the maintenance of @entity101 due to @entity1911 .
