In vivo and in vitro growth stimulation of XXXX @entity157 cells by glucocorticoid.

@entity1 @entity19 @entity5 @entity915 @entity98 @entity701 @entity157 @entity3927
An increased level of glucocorticoid receptors has been found in @entity157 . The aim of this study was to determine the in vivo effect of glucocorticoid on the growth of @entity19 @entity157 cells. In vitro cell growth was determined by @entity98 assay, while cell cycle progression was assayed with flow cytometry. For in vivo experiments, @entity1 and Hepa 1-6 cells were implanted in BALB/c and @entity915 @entity19 , respectively. Each @entity19 received 4 subcutaneous injections of @entity701 and/or @entity3927 after @entity5 implantation. We found that glucocorticoid treatment of @entity1 and Hepa 1-6 cells in vitro resulted in an increase in cell growth which was partially inhibited by @entity3927 , a glucocorticoid antagonist. Glucocorticoid treatment enhanced the cell cycle progression of @entity1 cells. The incidence of @entity5 in the @entity701 group was significantly higher than that of the saline, @entity3927 , or @entity701 plus @entity3927 groups. @entity3927 partially blocked the @entity701 -stimulated growth of @entity157 . Further study showed that glucocorticoid treatment of @entity915 @entity19 also stimulated Hepa 1-6 @entity5 growth. In conclusion, our results indicated that glucocorticoid directly stimulated @entity157 growth and this stimulation was not the result of immune suppression. Glucocorticoids may play an important role in regulating the growth of @entity157 .
