[Regional therapy of isolated liver metastases from XXXX ].

@entity1 @entity632 @entity0 @entity5 @entity1138 @entity253 @entity99 @entity1487
Because of the high rate of response in colorectal liver metastases, intra-arterial chemotherapy was studied in 14 @entity1 with isolated @entity0 . After extrahepatic metastasization had been ruled out, a catheter was placed surgically and connected to a cytostatic pump (in two cases) or to a subcutaneous infusion chamber (in 12 cases). Every four to six weeks, the @entity1 with an infusion chamber received a modified FAM treatment ( @entity1487 , @entity632 , @entity1138 ) for three days continuously. In 11 out of 14 @entity1 (79%) a clear @entity5 reduction was observed (duration of remission 11 months). In an average of six cycles of chemotherapy administered, a total of 50% of the @entity1 manifested local side effects (including two cases of @entity99 , one case of @entity253 ). Systemic side effects were negligible. Termination of therapy was necessitated by three catheter tip migrations and two @entity99 . Extrahepatic metastases occurred in six @entity1 . Here, the average latency period between diagnosis of the @entity5 and that of liver metastasis was significantly shorter (x = 9 months) than in the other @entity1 (x = 39 months). Intra-arterial chemotherapy thus represents a therapeutic method which, although complicated, is extremely effective in selected @entity1 with isolated @entity0 . A final evaluation must be subject to a randomized comparison with a systemic therapy.
