Branched-chain @entity3534 ameliorate XXXX with @entity299 in @entity35 .

@entity3534 @entity712 @entity353 @entity35 @entity5 @entity1283 @entity6288 @entity299 @entity2595
AIMS: @entity712 ( @entity712 ) is associated with changes in energy metabolism of the heart, as well as in extra-cardiac organs such as the skeletal muscles. @entity299 is a common complication and is associated with poor prognosis. Branched-chain @entity3534 (BCAAs) reportedly improve @entity6288 and @entity5 . We tested the hypothesis that @entity2595 ameliorates @entity712 with @entity299 . MAIN METHODS: We used Dahl salt-sensitive (DS) @entity35 fed a high-salt diet as a model of @entity712 . DS @entity35 fed a low-salt diet were used as a control. @entity2595 were administered in drinking water from 11weeks of age, when @entity1283 was established but the cardiac function was preserved. Survival and the cardiac function were monitored, and animals were sacrificed at 21weeks of age and analyzed. KEY FINDINGS: In @entity712 @entity35 , @entity2595 treatment decreased the heart rate, preserved the cardiac function, and prolonged survival. @entity2595 also prevented body @entity353 , associated with preservation of the skeletal muscle weight. Moreover, gene expression related to mitochondrial biogenesis and function was increased with @entity2595 in skeletal muscles. SIGNIFICANCE: @entity2595 preserved the body weight and cardiac function and prolonged survival in @entity712 @entity35 . The expression of genes involved in mitochondrial biogenesis and function in skeletal muscles was increased by @entity2595 .
