Soluble XXXX levels, @entity8729 polymorphisms and cardiovascular disease.

@entity1 @entity72804 @entity10133 @entity72805 @entity583 @entity8729 @entity72803 @entity453 @entity850 @entity72806
@entity8729 is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells and platelets. A number of polymorphisms in the gene encoding @entity8729 have been identified. Objectives were to investigate the relationship of soluble @entity10133 )-selectin with @entity8729 gene polymorphisms and @entity453 ( @entity453 ). Two hundred and forty-nine @entity1 , with extent of @entity453 characterized by >or=50% @entity850 in one or more coronary arteries, and 252 healthy controls were studied. Soluble @entity8729 was significantly higher in the @entity1 than controls after adjustment for age, sex and smoking [ @entity1 49.8 (47.5-52.1) ng mL-1; controls 46.7 (44.5-49.1) ng mL-1, P = 0.03). There was no association of sP-selectin with @entity583 ( @entity583 ) or presence of >or=50% @entity850 . The @entity72803 , @entity72804 and @entity72805 (but not the @entity72806 ) polymorphisms were in strong linkage disequilibrium. The @entity72806 polymorphism was significantly associated with sP-selectin even after adjustment for covariates [TT 48.9 (46.9-50.0) ng mL-1; TP + PP 40.7 (38.1-43.6) ng mL-1, P < 0.0001]. A significant interaction of @entity72806 and smoking status was identified in the determination of sP-selectin levels. There was no significant association of genotype at any of the polymorphism in relation to @entity583 or @entity850 . The @entity72806 polymorphisms is associated with plasma sP-selectin. This association is modulated by smoking, although the underlying mechanism remains unclear.
