Comparison of effects of alpha receptor blockers on endothelial functions and coagulation parameters in @entity1 with XXXX .

@entity1 @entity1423 @entity1067 @entity7477 @entity16427 @entity31503 @entity65 @entity9940 @entity1486
OBJECTIVE: To investigate the effects of alpha receptor blockers used in the treatment of @entity1067 ( @entity1067 ) on endothelial functions, coagulation parameters, and arterial blood pressure. MATERIALS AND METHODS: One-hundred fifteen @entity1 admitted to the treatment protocol because of symptomatic @entity1067 were included in this prospective study. @entity1 were given the following treatments: @entity16427 4 mg/d (n = 25), @entity7477 5 mg/d (n = 26), @entity31503 10 mg/d (n = 26), @entity9940 0.4 mg/d (n = 21), and observation (n = 17). All cases were evaluated before treatment and in the 12th week of treatment, according to biochemical parameters, endothelial functions, and arterial blood pressure. Biochemical parameters were bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, total @entity1486 (PSA), and free PSA. Endothelial functions were evaluated with ultrasonography of the brachial artery. RESULTS: When coagulation tests were evaluated, there were significant increases in bleeding and coagulation times in the groups using @entity16427 and @entity7477 . @entity16427 and @entity7477 lowered arterial blood pressure significantly compared with other treatments. With regard to effects on endothelial function, there were significant differences in flow-mediated dilation rates of the brachial artery at 60 and 90 seconds before and during treatment in the @entity31503 and @entity7477 groups. CONCLUSIONS: Alpha receptor blockers can decrease the risk of @entity65 by both reducing @entity1423 and protecting endothelial functions in @entity1 with @entity1067 . The only drug with a favorable effect in all 4 areas of interest, including @entity1067 , blood pressure, @entity1423 , and endothelial functions, was @entity7477 .
