XXXX causes aggregation of neutrophils and enhances @entity358 .

@entity6415 @entity1667 @entity2194 @entity2379 @entity95 @entity4515 @entity6922 @entity358 @entity11015 @entity4514 @entity8701
The influence of @entity2379 ( @entity11015 ) on the aggregation of @entity6415 ( @entity6415 ) was examined by means of in vitro aggregometry as well as in an in vivo model of @entity358 ( @entity358 ). The @entity11015 caused a dose-dependent aggregation of @entity6415 that was partially blocked by addition of serum to the drug prior to its reaction with the @entity6415 . No aggregation of @entity6415 was seen after the addition of @entity8701 , a similar polyene antibiotic. In vivo studies were conducted in @entity95 , where @entity358 was induced by an intravenous infusion of zymosan-activated plasma (ZAP) or @entity4514 ( @entity4515 ), and the degree of resulting @entity6922 was expressed as the number of @entity6415 per @entity2194 ( @entity2194 ). Animals in the control group had 6 +/- 3 @entity6415 / @entity2194 . This number increased to 12.4 +/- 5.6 when ZAP was infused and postmortem examination was performed 1 h later and to 17.4 +/- 4 if the examination was performed after 24 h. These numbers increased more than twice when @entity11015 (1 mg/kg) was infused together with the ZAP. Increased @entity358 after the infusion of ZAP and @entity11015 was not attenuated by prior administration of @entity1667 (30 mg/kg) to the animals. Infusions of @entity11015 per se caused no significant @entity358 but did cause increased pinocytosis in the pulmonary endothelium. Enhancement of @entity358 by @entity11015 was also examined in a model of PMA-induced @entity358 .(ABSTRACT TRUNCATED AT 250 WORDS)
