Reproducibility of the histopathological classification of @entity957 and XXXX .

@entity1 @entity1373 @entity957 @entity189 @entity1082 @entity5436
Invasive @entity189 has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. @entity1082 -related invasive @entity189 has basaloid or warty morphology and has adjacent basaloid or warty @entity5436 . @entity189 unrelated to @entity1082 is a keratinizing @entity957 that may have adjacent @entity1373 . We provided to 3 pathologists for their review and pathological diagnoses stained tissue sections from 95 @entity1 with @entity189 . The reproducibility for grading individual categories of intraepithelial lesions was only fair (kappa values of 0.31-0.43). The reproducibility was better (moderate to good; kappa values of 0.58-0.59) for grading individual categories of invasive @entity189 . The agreements improved when the basaloid and warty categories were combined. Good agreement was achieved (kappa values of 0.55-0.79) in distinguishing @entity1082 -related lesions from those unrelated to @entity1082 ; all three reviewers agreed on this classification for 67% of the cases. The intrareviewer agreement was of the same order as interreviewer agreement. Difficulties in differentiating between some lesions (e.g., a @entity189 with little atypia from a well- to moderately differentiated keratinizing @entity957 ) and concurrent occurrence of @entity1082 -related lesions and those lesions unrelated to @entity1082 in a @entity1 may account for some of the discrepancies in the histopathological diagnoses of @entity189 .
