XXXX secondary to cryolipolysis: An underreported entity?

@entity1 @entity1373 @entity82 @entity6561
BACKGROUND AND OBJECTIVE: Cryolipolysis is a non-invasive, safe, and effective treatment for localized fat reduction. @entity1373 ( @entity1373 ) is a rare adverse effect in which @entity1 develop painless, firm, and well-demarcated tissue masses in the treatment areas approximately 3-6 months following cryolipolysis. The incidence of @entity1373 has been estimated at 0.0051% or 1 in 20,000 treated @entity1 . We report two cases of @entity1373 seen in our practice, which may suggest the incidence is greater than previously reported. STUDY DESIGN/ @entity1 AND METHODS: A 44-year-old @entity1 underwent cryolipolysis for unwanted fat in the pectoral region. At 4 month follow-up, the @entity1 had well-demarcated tissue growth in the treatment areas. He elected to undergo additional cryolipolysis treatment to the areas. Two months later, he was found to have further tissue growth in the treatment areas. The @entity1 then underwent corrective treatment with liposuction. A 52-year-old @entity1 underwent cryolipolysis for unwanted lower abdominal fat. At one year follow-up, he had a well-demarcated, subcutaneous mass on the lower abdomen corresponding to the treatment site. The @entity1 elected to undergo corrective treatment with liposuction. Adipose tissue samples from the treated and non-treated areas, for control, were collected, processed, and stained to evaluate cellularity and tissue structure. RESULTS: In our practice, the incidence of @entity1373 is 0.47% or 2 in 422 cryolipolysis treatments. This is 100 times greater than the device manufacturer's reported incidence. Histopathologic examination of the subcutaneous tissue mass showed an increased number of adipocytes, @entity82 , and scar tissue in the treated areas when compared to controls. No lipoblasts, a marker of malignant neoplastic proliferation, were identified on the histopathologic examination of the affected tissues. CONCLUSION: The incidence of @entity1373 is likely underreported. Further investigation is necessary to elucidate its mechanism of action. By understanding the pathogenesis, this rare adverse effect may be avoided, or even utilized as a therapeutic alternative for the treatment of @entity6561 . Lasers Surg. Med.    2015 Wiley Periodicals, Inc.
