Antibiotic prophylaxis in aortic and peripheral arterial surgery in the presence of XXXX . Results of a prospective evaluation.

@entity1 @entity801 @entity3525 @entity295 @entity66 @entity5152 @entity3524 @entity281 @entity86 @entity1856
Over a 6-month period 124 @entity1 submitted to aortic or infra-inguinal arterial reconstruction were alternately allocated to receive @entity5152 plus @entity801 (CX/GM) for 48 hours or @entity3524 ( @entity3525 ) for 24 hours perioperatively. Evaluations during during the first month were performed by a blinded independent observer and @entity1 were followed for between 6 and 20 months. 63 @entity1 received CX/GM and 61 @entity3525 ; the groups were matched for @entity295 risk factors. @entity295 rates were: groin and abdominal wounds, CX/GM 5.4% (7 of 129), @entity3525 6.2% (8 of 127); graft, CX/GM 1.5% (1 of 63), @entity3525 3.3% (2 of 61). The differences were not statistically significant (p greater than 0.05). Virtually all wound @entity281 were superficial (class I) and no late @entity281 have emerged. 56 @entity1 had @entity66 and 68 had no lesion. There was no significant difference in wound or graft @entity295 rates between the 2 groups. Positive cultures of groin lymph nodes and/or aortic clot or @entity1856 did not predispose @entity1 to @entity86 . The organisms cultured from the extremity lesions were not found in infected wounds of abdominal surgery @entity1 . However, species type and antibiotic susceptibility patterns suggest that the same pathogens were present in wound @entity281 as were isolated from the extremity lesions of @entity1 who underwent infra-inguinal surgery. Thus direct, rather than lymphatic, contamination may be the major aetiological factor. Most infecting organisms were susceptible to the antibiotic used.
