Cerebral stimulation following @entity2900 in XXXX .

@entity1508 @entity428 @entity235 @entity2901 @entity2900
The effects of iv @entity2900 (SCh) on the electroencephalogram (EEG), cerebral blood flow (CBF), cerebral metabolic rate (CMRO2), @entity428 ( @entity428 ), central venous pressure (CVP), and mean arterial pressure (MAP) were tested in @entity1508 -anesthetized @entity235 . Six @entity235 were maintained at 0.87 +/- 0.00% (mean +/- SE) expired @entity1508 (1.0 MAC) and received both SCh 1.0 mg X kg-1 and lactated Ringer's solution placebo 0.05 ml X kg-1. @entity2901 began 24 +/- 4 s after iv SCh. @entity2901 were followed by immediate EEG arousal in five of six @entity235 and increases in CBF in all six. Average CBF was 151 +/- 14% of control for the 0-15 min measurement period and 127 +/- 7% of control for the 15-30 min period. Both were significantly greater than pre-SCh control values and placebo group values. Peak CBF of 177 +/- 19% of control occurred 3 min after iv SCh and was accompanied by a peak @entity428 of 435 +/- 131% of control. @entity428 values were significantly different between SCh and placebo treatments only during the periods of greatest CBF (1 to 5 min after iv SCh). Average PaCO2 values after iv SCh were significantly greater than pre-SCh control values and placebo values during each 15-min measurement interval. Average PaCO2 was 116 +/- 2% of control during the 0-15 min measurement period, 114 +/- 2% of control during the 15-30 min period, and 109 +/- 1% of control during the 30-45 min period. CVP, MAP, and CMRO2 did not significantly change after iv SCh.(ABSTRACT TRUNCATED AT 250 WORDS)
