Effect of severe neonatal morbidities on long term outcome in extremely low birthweight XXXX .

@entity1545 @entity1 @entity73 @entity245 @entity1939 @entity2107 @entity1448 @entity989 @entity393 @entity204 @entity306
PURPOSE: To assess the validity of individual and combined prognostic effects of severe @entity2107 ( @entity2107 ), @entity1545 , @entity989 ( @entity989 ), and parenteral nutrition associated @entity1448 (PNAC). METHODS: We retrospectively analyzed the medical records of 80 extremely low birthweight (ELBW) @entity1 admitted to the neonatal intensive care unit (NICU) of the Severance @entity1 's Hospital, and who survived to a postmenstrual age of 36 weeks. We analyzed the relationship between 4 neonatal morbidities (severe @entity2107 , severe @entity1545 , severe @entity989 , and severe PNAC) and poor outcome. Poor outcome indicated @entity204 after a postmenstrual age of 36 weeks or survival with @entity73 ( @entity306 , @entity245 , @entity393 , or @entity1939 ) between 18 and 24 months of corrected age. RESULTS: Each neonatal morbidity correlated with poor outcome on univariate analysis. Multiple logistic regression analysis revealed that the odds ratios (OR) were 4.9 (95% confidence interval [CI], 1.0-22.6; P=0.044) for severe @entity2107 , 13.2 (3.0-57.3; P<.001) for severe @entity1545 , 5.3 (1.6-18.1; P=0.007) for severe @entity989 , and 3.4 (0.5-22.7; P=0.215) for severe PNAC. Severe @entity2107 , @entity1545 , and @entity989 were significantly correlated with poor outcome, but not severe PNAC. By increasing the morbidity count, the rate of poor outcome was significantly increased (OR 5.2; 95% CI, 2.2-11.9; P<.001). In @entity1 free of the above-mentioned morbidities, the rate of poor outcome was 9%, while the corresponding rates in @entity1 with 1, 2, and more than 3 neonatal morbidities were 46%, 69%, and 100%, respectively. CONCLUSION: In ELBW @entity1 3 common neonatal mornidifies, severe @entity2107 , @entity1545 and @entity989 , strongly predicts the risk of poor outcome.
