Prevalence of XXXX genotypes in cytologic abnormalities from unvaccinated @entity1 living in north-western Spain.

@entity1 @entity146 @entity5 @entity75 @entity957 @entity1083 @entity281 @entity3799 @entity1799 @entity1082 @entity2784
@entity5 and its precursors @entity2784 ( @entity2784 ) and @entity2784 ( @entity2784 ) are associated with @entity281 by @entity1082 ), in particular @entity1799 and 18. The distribution of the HPV genotype varies with the severity of @entity3799 , age and the geographic location of the @entity1 . We report the results of a population study carried out in a region of north-western (NW) Spain aimed at determining the prevalence of single and @entity281 by 35 types of HPV using low-density microarrays for 113 cases with negative for @entity75 or @entity5 ; 588 with atypical squamous cells of undetermined significance (ASCUS)/ @entity2784 ; 183 with @entity2784 ; and seven cases of @entity957 . Of the 891 @entity1 analysed, 50.2% had single @entity281 and 49.8% had @entity1083 . In @entity1 aged below 30 years, there was a predominance of @entity281 (p = 0.027). ASCUS/ @entity2784 was associated with multiple and @entity2784 with single @entity281 (p = 0.025). We observed significant @entity281 due to a high-risk (HR) type of HPV when the severity of the cytological lesion increased (p = 0.001). No relationship was found between greater @entity146 in the cytological diagnosis and a higher number of HPV types involved in @entity281 . The five most frequent genotypes were @entity1799 (26.3%), 53 (18.2%), 51 (17.3%), 6 (14.8%) and 66 (13.1%). The prevalence of @entity1799 , 33 and 58 increased significantly from ACUS/ @entity2784 to @entity2784 and the prevalence of HPV 51, 53 and 66 decreased. @entity1799 was the only genotype that showed a significant increase in prevalence when the severity of the cytological disease increased in single @entity281 (p = 0.0001). The implementation of bivalent prophylactic vaccination could potentially lead to prevention in 32% of the population included in the study - in at least a quarter of @entity1 with ACUS/ @entity2784 (26.7%), and in half of @entity2784 (50.2%).
