Rotational behavior and electrophysiological effects induced by @entity1246 (B) receptor activation in XXXX globus pallidus.

@entity2227 @entity1246 @entity7234 @entity12780 @entity1023 @entity35 @entity1772
@entity1246 is the major neurotransmitter used in the globus pallidus and there is evidence that @entity1246 (B) receptors exist in this nucleus. Here we show that unilateral microinjection of @entity1772 , a @entity1246 (B) receptor agonist, induced ipsilateral turning in @entity35 . This effect was prevented by preinjection of the @entity1246 (B) receptor antagonist @entity7234 , which itself did not cause rotation. Thus, activation of @entity1246 (B) receptor may suppress the activity of globus pallidus neurons, which is in line with the finding that the @entity2227 receptor antagonists @entity12780 and @entity1023 also caused similar ipsilateral turning when injected into globus pallidus. Furthermore, in the presence of these @entity2227 receptor antagonists, injection of @entity1772 resulted in fewer rotations. To test the possibility that @entity1772 reduced @entity2227 release onto globus pallidus neurons, the effects of @entity1772 on miniature excitatory postsynaptic currents were studied in @entity35 brain slices. Patch-clamp recordings showed that @entity1772 at 30 microM significantly reduced the frequency of the miniature excitatory postsynaptic currents. However, @entity1772 induced a weak outward current only in a minority of globus pallidus neurons. These pre- and postsynaptic effects of @entity1772 were reversed or prevented by @entity7234 . These results suggest that @entity1246 (B) receptor in globus pallidus plays an important role in the regulation of movement by modulating glutamatergic inputs at a presynaptic site.
