Effect of XXXX on the consequences of acute alcohol consumption in @entity1 .

@entity1 @entity137 @entity146 @entity620 @entity412 @entity880 @entity1068 @entity2388
This study examines the influence of @entity620 pretreatment on @entity1068 clearance, @entity137 , and @entity146 after an acute dose of @entity1068 in @entity1 . @entity620 or a placebo was given to 20 healthy male subjects for 2 weeks before @entity1068 consumption. The dose of @entity1068 was 0.95 gm/kg body weight and was consumed during a 2 1/2-hour period. Thirty minutes after @entity1068 consumption, motor coordination and intellectual function were assessed by Goldberg's "Finger-Finger" and "Serial Sevens" tests. In addition, color discrimination was measured with the use of the Farnsworth-Munsell 100 Hue Color Test. Hourly blood samples were taken for 10 hours after @entity1068 consumption to measure serum @entity412 levels, blood @entity880 / @entity2388 ratios, and serum enzymes. Blood @entity1068 clearance was also determined. @entity1068 consumption elevated serum @entity412 levels and blood @entity880 / @entity2388 ratios and impaired performance of the behavioral tests but did not alter serum enzyme levels. @entity620 pretreatment resulted in significant enhancement in blood @entity1068 clearance and an increase in serum @entity412 levels after @entity1068 consumption in half of the subjects. @entity620 pretreatment also resulted in improved motor coordination and color discrimination after @entity1068 consumption in half of the subjects. @entity620 pretreatment did not influence elevated blood @entity880 / @entity2388 ratios or impaired intellectual function.
