Is increased body mass index associated with the incidence of XXXX ?

@entity5 @entity1 @entity28 @entity4797
PURPOSE: Epidemiological and ecological evidences suggest a positive association of overweight and @entity28 with the risk of @entity5 (GCC). Previous controlled trials reported conflicting results. The present study aimed to analyse the putative association of overweight with GCC risk in a large @entity1 sample and to summarize previous data. METHODS: A total of 8,498 GCC @entity1 were enrolled in a nationwide multicentric case control study. Self-reported body dimensions were recorded for calculation of the body mass index (BMI; kg/m(2)). For comparison, 2,070 age-matched male probands of the latest German National Health Survey (NHS) were employed. @entity1 and controls were categorized according to age as follows: 18-29, 30-39, and 40-49 years, respectively, and according to BMI, as follows: <18.5; 18.5 to <25; 25 to <30; >30 kg/m(2), respectively. Frequencies of BMI-categories in the three age groups were tabulated and compared statistically. The literature was searched for previous controlled trials regarding BMI and GCC risk. RESULTS: The median BMI of all GCC @entity1 is 24.69 kg/m(2). Overall comparison of frequencies of BMI categories of cases and controls did not reveal any significant difference. However, in young @entity1 (18-29 years) BMI categories 25 to <30 kg/m(2) and >30 kg/m(2) were significantly more frequent in GCC @entity1 than in controls (p < 0.00001). Nineteen previous studies were identified in the literature, one of which being clearly in accordance with the present hypothesis, one being antithetical while the remaining studies were inconclusive in various aspects. CONCLUSION: The results of this population-based study lend support to two hypotheses regarding the pathogenesis of GCC: First, as high-calorie nutrition is the most important reason for increased BMI, it appears conceivable that nutritional factors are involved in the pathogenesis of GCC. Second, as nonseminoma is the most prevalent histological subtype among younger @entity1 , the association of increased BMI with incidence of GCC in this particular subgroup may point to divergent pathogenetic pathways of nonseminoma and @entity4797 , respectively.
