A putative ketogenic diet elicits mild nutritional XXXX but does not impair the acute or chronic @entity1184 responses to resistance exercise in rodents.

@entity8928 @entity7949 @entity1184 @entity1735 @entity4322 @entity1270 @entity35 @entity72677 @entity3689 @entity121 @entity413
UNASSIGNED: We examined whether @entity121 is impaired with a low @entity1735 diet formulated to elicit @entity1270 (LCKD) versus a mixed-macronutrient @entity8928 ( @entity8928 ). Male @entity35 (9-10 weeks of age, 300-325 g) were provided isoenergetic amounts of a LCKD or a @entity8928 for 6 weeks. In @entity72677 , basal serum and gastrocnemius assessments were performed. In @entity7949 , @entity35 were resistance-exercised for one bout and were euthanized 90-270 min following exercise for gastrocnemius analyses. In AIM 3, @entity35 voluntarily-exercised daily using resistance-loaded running wheels, and hind limb muscles were analyzed for @entity1184 markers at the end of the 6 week protocol. In @entity72677 , basal levels of gastrocnemius phosphorylated (p)-rps6, p-4EBP1 and p-AMPKa were similar between diets, although serum insulin (P<0.01), serum @entity413 (P<0.001), and several essential @entity3689 levels (P<0.05) were lower in LCKD-fed @entity35 . In @entity7949 , LCKD- and @entity8928 -fed @entity35 exhibited increased post-exercise muscle protein synthesis (MPS) levels (P<0.0125), but no diet effect was observed (P=0.59). In AIM 3, chronically exercise-trained LCKD- and @entity8928 -fed @entity35 presented similar increases in relative hind limb muscle masses compared to their sedentary counterparts (12-24%, p<0.05), but there was no between-diet effects. Importantly, the LCKD induced 'mild' nutritional @entity1270 , as the LCKD-fed @entity35 in @entity7949 exhibited ~1.5-fold greater serum @entity4322 levels relative to @entity8928 -fed @entity35 (diet effect P=0.003). This study demonstrates that the tested LCKD in rodents, while only eliciting mild nutritional @entity1270 , does not impair the acute or chronic skeletal muscle @entity1184 responses to resistance exercise.
