Feasibility of Elective Nodal Irradiation (ENI) and Involved Field Irradiation (IFI) in Radiotherapy for the Elderly XXXX (Aged >=  70 Years) with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute.

@entity1 @entity137 @entity2910 @entity1544 @entity1349
PURPOSE: We conducted a retrospective analysis to assess the feasibility of involved field irradiation (IFI) in elderly @entity1 with @entity1544 ( @entity1544 ). MATERIALS AND METHODS: We performed a retrospective review of the records of elderly @entity1 (>=  70 years) with unresectable @entity1544 and no distant metastases who received treatment with radiotherapy between January 2009 and March 2013. According to the irradiation volume, @entity1 were allocated into either the elective nodal irradiation (ENI) group or the IFI group. Overall survival (OS), @entity1349 ( @entity1349 ) and treatment-related @entity137 were compared between the two groups. RESULTS: A total of 137 @entity1 were enrolled. Fifty-four @entity1 (39.4%) were allocated to the ENI group and 83 @entity1 (60.6%) to the IFI group, the median doses in the two groups were 60 Gy and 59.4 Gy, respectively. For the entire group, the @entity1349 ( @entity1349 ) and @entity1349 were 16 months and 12 months, respectively. The median @entity1349 and 3-year @entity1349 rate in the ENI group were 13 months and 20.6%, compared to 11 months and 21.0% in the IFI groups (p = 0.61). The @entity1349 and 3-year OS rate in the ENI and IFI groups were 17 months and 26.4% and 15.5 months and 21.7%, respectively (p = 0.25). The rate of grade >=  3 acute irradiation @entity2910 in the ENI group was significantly higher than that in the IFI group (18.5% vs. 6.0%; p = 0.027). Other grade >=  3 treatment-related @entity137 did not significantly differ between the two groups. CONCLUSIONS: IFI resulted in decreased irradiation @entity137 without sacrificing OS in elderly @entity1 with @entity1544 .
