Massive XXXX intoxication: evaluation of plasma extraction.

@entity1 @entity1169 @entity2743 @entity1955 @entity772 @entity2016 @entity701 @entity5652 @entity943 @entity1002
Six @entity1 were admitted after erroneous massive intake of @entity1955 (70-1200 mg over an interval of 2-12 days). All @entity1 developed classical symptoms of @entity2743 within 3 days of the first dose; five @entity1 presented @entity772 and one became stuporous (days 7-10). Two @entity1 developed @entity1002 and three had @entity943 (days 8-11). Total thyroid hormone levels in serum on admission ranged 935-7728 nmol/l for T4 (TT4) and 23-399 nmol/l for T3 (TT3). All @entity1 received treatment with @entity701 and @entity1169 . @entity5652 was also given in 3 cases. Extractive techniques (charcoal haemoperfusion and/or plasmapheresis) were initiated 8-14 days after the first dose of @entity2016 . The plasma disappearance rate (K) of TT4 with plasmapheresis was 30 times higher, on average, than under standard medical treatment (M). Also, K of TT4 under haemoperfusion was about five times higher than K under M. K changes for TT3 were higher under haemoperfusion than under plasmapheresis. Furthermore, extractive procedures shortened the average half life of TT4, (from 106.5 +/- 44.6 to 59.7 +/- 20.2 h, p less than 0.05).
