Influence of endotoxin on the intrarenal distribution of @entity801 , @entity5153 , @entity2890 , @entity4509 , and XXXX .

@entity801 @entity8 @entity2890 @entity5898 @entity4509 @entity5821 @entity5153 @entity581 @entity35 @entity526
Multiple factors may modify the pharmacokinetics of @entity581 and increase their nephrotoxic potential. In this study, we investigated the influence of @entity526 endotoxin on the renal handling of several @entity581 and one @entity5898 . Drug levels in the @entity8 , as well as several parameters of renal function and histology, were compared in @entity35 treated with endotoxin (0.25 mg/kg) and normal @entity35 treated with either @entity801 (10 mg/kg), @entity5153 (10 mg/kg), @entity2890 (10 mg/kg), @entity4509 (50 mg/kg), or @entity5821 (100 mg/kg). Blood pressure and pulse rate were recorded. Endotoxin was associated with a decrease in the half-life and in the apparent volume of distribution of @entity801 . The endotoxin-injected animals accumulated significantly (P less than 0.05) more @entity581 in their kidneys than the normal animals. The amount of @entity5821 recovered in the @entity8 was identical in both groups. Slight decreases in the glomerular filtration rate and renal plasma flow were observed after endotoxin treatment. Blood pressure and cardiac frequency were minimally affected by endotoxin. No histological lesions were observed by light microscopy in animals receiving endotoxin. Thus, endotoxin modifies the renal handling of @entity581 in the absence of any major physiological disturbance or histological change. By increasing the total amount of @entity8 , endotoxin might increase the nephrotoxic potential of @entity581 .
