[ XXXX and CD24v].

@entity1 @entity1252 @entity11707 @entity3929 @entity4857 @entity15
BACKGROUND: @entity1252 is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. @entity11707 gene can mediate various functions such as their costimulatory activity in the clonal expansion of T cells. The single nucleotide polymorphism, resulting in a non-conservative replacement of @entity3929 to @entity4857 (CD24v) precedes immediately GPI anchorage site (position   -1), determines @entity11707 loss activity. CD24v has been associated with @entity15 and @entity1252 in other populations. OBJECTIVE: To find the presence of CD24v in Mexican @entity1 with @entity1252 . MATERIAL AND METHOD: A study of fenotyping of @entity11707 v included 65 subjects, 32 cases ( @entity1252 ): 28 @entity1 and 4 @entity1 ; and 32 controls: 9 @entity1 and 23 @entity1 ; cases and controls from @entity1 with @entity1252 in National Medical Center 20 de Noviembre ISSSTE, Mexico City, services of Clinical Immunology and Rheumatology. RESULTS: In cases, 19 @entity1 had a wild homozygous genotype, 12 were heterozygous and only one @entity1 showed homozygous polymorphism. In controls, 17 showed wild heterozygous genotypes; 14 were heterozygous and 1 was found to be polymorphic homozygote. With odds ratio: 0.84 and chi-squared of 0.17; therefore there was no statistically significant difference. CONCLUSIONS: Study population showed that there is no statistically significant difference between @entity1252 cases and controls with respect to the presence of CD24v.
