Increased intestinal permeability associated with @entity281 in burn XXXX .

@entity1 @entity2656 @entity295 @entity11884 @entity281 @entity130
@entity130 may be associated with disruption of normal gut barrier integrity. To test this hypothesis, we assessed intestinal permeability with the nonmetabolizable, poorly absorbed disaccharide @entity11884 , which is efficiently excluded by the normal intestinal mucosa. Permeability studies were performed in 15 burned @entity1 (aged 18 to 67 years; mean burn size, 40%) and 11 healthy controls. @entity11884 , 10 g, was administered enterally, together with 5 g of @entity2656 as a control, and urinary excretion rates were determined. @entity11884 excretion and the @entity11884 / @entity2656 excretion ratio increased threefold (160 +/- 30 vs 57 +/- 7 mumol and 0.113 +/- 0.033 vs 0.035 +/- 0.005) in the infected @entity1 ( @entity295 score, 10 +/- 2; burn size, 38% +/- 6%). In contrast, noninfected burn @entity1 ( @entity295 score, 0) had permeability values similar to those of controls (66 +/- 10 mumol and 0.036 +/- 0.007). Permeability increased as the severity of @entity281 increased. Infection in burn @entity1 is associated with increased bowel permeability. The intestine may be a primary source of @entity295 . Alternatively, the systemic response to @entity281 may alter gut barrier function, which could facilitate translocation of bacteria and absorption of endotoxin.
