Decreased bilateral thalamic @entity62 volume in first-episode XXXX with prominent hallucinatory symptoms: A volumetric MRI study.

@entity1 @entity62 @entity161 @entity1833
UNASSIGNED: Studies comparing @entity62 ( @entity62 ) volume of @entity161 @entity1 with or without auditory verbal @entity1833 (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of @entity62 volumes of drug-na  ve @entity161 @entity1 with and without AVHs. Eighteen first episode @entity161 (FES) @entity1 with AVHs, 18 FES @entity1 without AVHs, and 18 healthy controls were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted to investigate changes of @entity62 volume among the three groups. @entity1 with and without AVHs exhibited reduced @entity62 volumes relative to normal controls in the left superior temporal gyrus, frontal regions, cerebellum and caudate. Further analysis of the @entity62 of subcortical structures found that @entity1 with AVHs had reduced thalamic volume than healthy controls. No significant difference was found between @entity1 with and without AVHs. Significant correlation was found between the total scores of the Positive and Negative Syndrome Scale and bilateral thalamic volume. ROC analysis of thalamic volumes of the @entity1 with AVHs and normal controls showed that the area under the curve was 0.698 (P   =   0.043). The decreased thalamic volumes might serve as a biomarker for discriminating FES AVHs @entity1 from normals.
