Stereotactic ablative body radiation therapy for XXXX in the lung in octogenarians: a retrospective single institution study.

@entity1 @entity137 @entity55 @entity5 @entity358 @entity3 @entity158
BACKGROUND: Treatment of @entity5 in the lung in octogenarians is limited by their health and functional status. Stereotactic ablative radiotherapy is an established noninvasive treatment option for medically inoperable @entity1 , with a @entity137 profile that may be more tolerable in elderly @entity1 . METHODS: @entity1 more than 80  years old treated with stereotactic ablative radiotherapy for @entity5 in the lung between January 2007 and August 2012 at a single institution were identified and retrospectively analyzed for @entity137 and survival. RESULTS: Thirty @entity1 were identified with a total of 32 lesions treated. @entity1 ranged in age from 80.8 to 90.7  years old (median 84.9) at the time of treatment. Twenty @entity1 had ECOG performance status 0-1, and 10 had performance status 2-3. Stage distribution at treatment was: stage I (20 @entity1 ), stage III (1), stage IV (1), and 8 recurrent @entity5 . @entity1 were treated to a median total dose of 54  Gy in 3 fractions (range 20-60  Gy in 1 to 5 fractions). Median follow up was 13  months (range 2-60 months). Fifteen @entity1 were still living at last review. There was one failure in field and one failure in the same lobe that was treated. One @entity1 died with progressive regional disease, and four died of progressive @entity3 . Three @entity1 had late grade 3 @entity358 with no grade 4 or 5 @entity137 . One @entity1 had late grade 2 @entity55 , and 3 @entity1 had late grade 1 @entity55 . Three @entity1 had grade 1 chest wall @entity158 . CONCLUSIONS: Octogenarians tolerated ablative treatment with minimal @entity137 . Stereotactic ablative body radiotherapy is an option to consider in treatment of elderly @entity1 .
