Protective effects of @entity1502 on @entity99 induced by @entity7008 in XXXX .

@entity2796 @entity7008 @entity32 @entity82 @entity2041 @entity4045 @entity6172 @entity1234 @entity1502 @entity224 @entity35 @entity4026 @entity99 @entity1865
@entity1502 ( @entity4045 ) is a non-selective phosphodiesterase inhibitor with the effects of antioxidation, anti- @entity32 and anti- @entity82 that has been shown to induce damage in liver. The purpose of this study is to investigate the effects and possible mechanisms of @entity4045 on @entity7008 ( @entity2796 )-induced @entity99 in @entity35 . Male Sprague-Dawley (SD) @entity35 were divided into four groups: control, @entity4045 , @entity2796 and @entity4045 + @entity2796 treated groups. @entity35 were administrated @entity2796 together with or without @entity4045 for a week and sacrificed 24 h after the last intragastric administration of @entity4045 . Histopathological analysis was carried out. The liver function, the indices of oxidative stress including @entity1234 ( @entity1865 ), @entity224 dismutase (SOD), and @entity2041 ( @entity6172 ) in liver tissues, and pro-inflammatory cytokines expressions were examined. The mRNA level of @entity4026 p65 in liver was also determined. @entity4045 significantly attenuated @entity2796 -induced @entity99 . The serum transaminase and @entity1865 levels were reduced while the levels of SOD and @entity6172 were increased, as compared with the @entity2796 -treated group. @entity4045 also remarkably suppressed the secretions of pro-inflammatory cytokines and the @entity4026 ( @entity4026 ) activation induced by @entity2796 . In addition, the histopathological analysis showed that the range and degree of liver tissue lesions were improved obviously in @entity4045 treated group. @entity1502 could ameliorate the effects of @entity7008 -induced @entity99 in @entity35 by inhibiting oxidative stress, expressions of pro-inflammatory cytokines and @entity4026 activation.
