[Estrogens and XXXX ].

@entity1 @entity2931 @entity195
Several factors lead to a higher number of female @entity1 with @entity195 , and thus prevention and treatment are of particular concern to @entity1 . Given the slow development of histopathological alterations in @entity195 , prevention should start early in life. Several lines of evidence document in vitro and in vivo a protective effect of @entity2931 on neurons. @entity1 substitute @entity2931 during the immediate postmenopausal years, and this offers a natural experiment for testing the preventive action of @entity2931 against @entity195 . Case control studies and cohort studies support a general protective effect of hormone (i.e. @entity2931 ) replacement therapy (HRT). Short-term and small-scale intervention trials in @entity1 with @entity195 show positive results. However, it is not clear to what extent cognition is improved by the known effects of @entity2931 on mood and behavioural symptoms. More studies are needed to establish the value of @entity2931 replacement therapy in primary and secondary prevention of @entity195 . At present, @entity2931 can be recommended in @entity1 at risk for @entity195 and as adjuvant therapy in mild early @entity195 .
