[Fundamental study on ceftizoxime suppositories in adults and XXXX ].

@entity1 @entity8934 @entity809 @entity27145 @entity158
The pharmacokinetics of newly developed ceftizoxime suppository ( @entity8934 -S) was studied in healthy volunteers and in @entity1 , compared with that of intramuscular @entity8934 and intravenous @entity8934 : In 8 volunteers (aged 19 to 24 years), each of 500 mg (potency) @entity8934 -S containing 3%, 4% and 5% @entity27145 was compared with 500 mg intramuscular @entity8934 and 500 mg intravenous @entity8934 as a single administration in the cross-over method. In addition each of 500 mg @entity8934 -S containing 4% and 5% @entity27145 was studied in 2 groups of 8 volunteers (aged 22 to 24 years) and of 8 volunteers (aged 19 to 27 years); each @entity8934 -S was given 3 times a day successively for 5 days. The pharmacokinetics of 125 mg and 250 mg @entity8934 -S, which contained 3% @entity27145 , were also evaluated as a single administration in 9 @entity1 (aged 6 years 4 months to 12 years 0 month) and in 11 @entity1 (aged 7 years 8 months to 12 years 4 months), respectively. The irritabilities of @entity8934 -S were studied in all subjects who participated in this trial. The feeling of foreign body, the feeling of @entity809 and the @entity158 were evaluated in volunteers; the feeling of defecation and the @entity158 were evaluated in @entity1 . The results were as follows: I. Pharmacokinetics in healthy volunteers 1. Given as a single administration The mean peak concentrations of serum @entity8934 were occurred 30 minutes after 500 mg @entity8934 -S containing 3%, 4% and 5% @entity27145 , which were 10.5 mcg/ml, 12.3 mcg/ml and 12.4 mcg/ml, respectively. These values were 1.35 mcg/ml, 1.60 mcg/ml and 1.69 mcg/ml at the conversion unit of 1 mg dose per 1 kg body weight. The mean peak serum @entity8934 concentration of @entity8934 -S containing 3% @entity27145 was slightly lower than that of @entity8934 -S containing 4% or 5% @entity27145 , but was 1.9 times higher than that of the ABPC suppository. There was no marked difference among 3 preparations of @entity8934 -S in mean Tmax and T1/2. Cmax of @entity8934 -S containing 3% @entity27145 was 1.40 mcg/ml at the conversion unit of 1 mg/kg. AUC of @entity8934 -S containing 3% @entity27145 was slightly smaller than that of @entity8934 -S containing 4% or 5% @entity27145 , but 3.1 times that of the ABPC suppository in healthy volunteers. When 500 mg @entity8934 was intramuscularly administered by one shot to 8 volunteers, Tmax was same as that of @entity8934 -S or was slightly later.(ABSTRACT TRUNCATED AT 400 WORDS)
