Efficacy of platelet-rich-plasma (PRP) in bone regeneration after cyst enucleation in pediatric XXXX --a clinical study.

@entity1 @entity154
BACKGROUND: Platelet-rich-plasma (PRP) is a type of natural source of autologous growth factors, and has been used successfully in various fields. However the use ofPRP in @entity1 is not well documented. OBJECTIVE: To evaluate the efficacy of adding PRP to a bone graft in the bone regeneration of @entity154 following cystectomy. STUDY DESIGN: Study sample included 20 @entity1 who were randomly divided into two groups with 10 @entity1 in each group; all underwent cystectomy In the first group (test group), after cystectomy the @entity154 was filled with PRP and bone graft. In the second group (control group) bone graft alone (without PRP) was used. Radiographs were recorded at 1 month, 2 months, 4 months and 6 months intervals after surgery to evaluate the defect bone fill in both groups. RESULTS: The post-operative successive radiographs in the test group showed a significantly greater regeneration of bone in the height of @entity154 with application of PRP to bone graft as compared to the control group. In the test group, by the first post operative month, about 58% of the defect was filled, which gradually increased in each month and showed about 94% of defect-fill by 6 months. In the control group, similar observation revealed only 31% of defect-fill by the first post-operative month and a 47% defect-fill at 6 months. CONCLUSION: The addition of PRP to bone graft appeared to enhance bone regeneration considerably. The combination of PRP and bone graft might have a potential for routine clinical use for regeneration of @entity154 in @entity1 .
