Pilot study of @entity4678 in XXXX with @entity191 and dopa-unresponsive Freezing of Gait.

@entity1 @entity26680 @entity409 @entity191 @entity4678 @entity6556 @entity942
BACKGROUND: Freezing of gait ( @entity6556 ) is a common and debilitating condition in @entity191 ( @entity191 ) associated with @entity409 . A subtype of @entity6556 does not respond to dopaminergic therapy and may be related to @entity942 . This pilot study explores the effects of @entity4678 on gait in @entity191 @entity1 with dopa-unresponsive @entity6556 using a novel paradigm for objective gait assessment. FINDINGS: Ten @entity1 with @entity191 and dopa-unresponsive @entity6556 were enrolled in this eight-week open label pilot study. Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning, while performing a dual task. Clinical, and subjective assessments of gait, quality of life, and safety were also administered. The primary outcome was a validated subjective assessment for @entity6556 ( @entity6556 ). @entity4678 was well tolerated, however, no significant change was observed in the primary outcome. The gait analysis protocol correlated well with clinical scales, but not with subjective assessments. @entity26680 @entity1 were more likely to increase gait velocity (p   =   0.033), and improved in other clinical assessments. CONCLUSIONS: Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this @entity1 population, and may be superior correlates of @entity6556 severity than subjective measures. These findings can inform future trials in this population.
