The impact of @entity1150 in @entity3124 XXXX : a meta-analysis of major clinical outcomes.

@entity1 @entity4736 @entity3124 @entity1151 @entity1150 @entity1213 @entity1211
BACKGROUND: @entity3124 @entity1 appear to be at high risk of developing @entity1150 ( @entity1150 ) and @entity1151 during their stay in the @entity1213 ( @entity1213 ). However, little is known about the clinical course of @entity1211 in the @entity1213 setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of @entity1150 on hospital and @entity1213 stay, duration of mechanical ventilation and mortality in @entity3124 @entity1 . We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the @entity1213 setting. MATERIALS AND METHODS: MEDLINE and EMBASE databases were searched up to week 4 of June 2012. Two reviewers selected studies and extracted data. Pooled results are reported as relative risks and weighted mean differences and are presented with 95% confidence intervals (CI). RESULTS: Seven studies for a total of 1,783 @entity1 were included. A diagnosis of @entity1150 was frequent in these @entity1 with a mean rate of 12.7% (95% CI: 8.7-17.5%). @entity1150 @entity1 had longer @entity1213 and hospital stays compared to those without @entity1150 (7.28 days; 95% CI: 1.4-13.15; and 11.2 days; 95% CI: 3.82-18.63 days, respectively). The duration of mechanical ventilation was significantly increased in @entity1150 @entity1 (weighted mean difference: 4.85 days; 95% CI: 2.07-7.63). @entity1150 @entity1 had a marginally significant increase in the risk of hospital mortality (relative risk 1.31; 95% CI: 0.99-1.74; p=0.06), and a not statistically significant increase in the risk of @entity1213 mortality ( @entity4736 .64; 95% CI: 0.91-2.93; p=0.10). CONCLUSIONS: A diagnosis of @entity1150 upon @entity1213 admission appears to affect clinically important outcomes including duration of @entity1213 and hospital stay and hospital mortality. Larger, prospective studies are warranted.
