Influence of comorbid conditions on long-term mortality after pneumonia in older XXXX .

@entity1 @entity712 @entity64 @entity174 @entity5 @entity497
OBJECTIVES: To test the hypothesis that increased long-term mortality after hospitalization for @entity497 ( @entity497 ) is independent of comorbid conditions. DESIGN: Prospective observational cohort study in metropolitan areas. SETTING: Memphis, Tennessee, and Pittsburgh, Pennsylvania. @entity1 : Three thousand seventy-five subjects aged 70 to 79 over 5.2 years. MEASUREMENTS: Unadjusted and adjusted mortality from an initial hospitalization for @entity497 were compared with mortality from different causes of hospitalization, including @entity5 , @entity174 , @entity712 ( @entity712 ), @entity64 ( @entity64 ), and other causes. Demographics, smoking, nutritional markers, functional status, inflammatory markers, and chronic health conditions were adjusted for. RESULTS: Of the 106 subjects hospitalized for @entity497 , 22 (20.8%) and 38 (35.8%) died at 1 and 5 years. Subjects hospitalized with @entity497 had higher mortality than nonhospitalized subjects (adjusted odds ratio (OR)=7.8, 95% confidence interval (CI)=4.2-14.4). One- and 5-year mortality after @entity497 hospitalization were higher than mortality from other causes requiring hospitalization and remained unchanged in multivariable analysis (adjusted OR=3.5, 95% CI=1.5-8.1; adjusted OR=5.6, 95% CI=2.8-11.2, respectively). One- and 5-year mortality after hospitalization for @entity497 were similar to or higher than mortality after an initial hospitalization for @entity712 , @entity64 , or @entity174 . Rehospitalization was common in subjects hospitalized for @entity497 and may explain greater long-term mortality. CONCLUSION: In this high-functioning cohort of older @entity1 , an initial hospitalization for @entity497 was associated with greater long-term mortality, independent of prehospitalization comorbid conditions. Hospitalization for @entity497 has as serious a prognosis as hospitalization for @entity712 , @entity64 , or major @entity174 .
