Off-pump coronary bypass grafting is associated with less XXXX than coronary bypass surgery with cardiopulmonary bypass.

@entity1 @entity296 @entity63 @entity16894 @entity358 @entity453
BACKGROUND: Excessive @entity296 following coronary artery bypass grafting is associated with adverse outcome. The present study was designed to assess the extent of @entity296 after conventional coronary artery bypass grafting with @entity358 (ONCAB) compared with @entity453 ( @entity453 ). METHODS: Measurements of serum cardiac troponin T ( @entity16894 ) were obtained in 137 consecutive, unselected @entity1 who underwent coronary artery bypass grafting. Serial blood sampling was performed at 3 time intervals after surgery: immediately postoperatively, 6 to 12 hours postoperatively, and 18 to 24 hours postoperatively. RESULTS: ONCAB @entity1 totaled 122, and @entity453 @entity1 numbered 15. Ten @entity1 in the ONCAB group suffered perioperative complications, compared with no @entity1 in the @entity453 group. At each time point examined, @entity453 @entity1 exhibited significantly less release of @entity16894 than ONCAB @entity1 (immediately postoperative @entity16894 , 1.99 +/- 4.75 ng/mL versus 0.20 +/- 0.32 ng/mL, P =.004; 6- to 12-hour @entity16894 , 2.28 +/- 3.66 ng/mL versus 0.37 +/- 0.32 ng/mL, P =.001; and 18- to 24-hour @entity16894 1.59 +/- 3.49 ng/mL versus 0.30 +/- 0.32 ng/mL, P =.01). When ONCAB @entity1 with perioperative @entity63 complications were excluded, the differences between the 2 groups remained. The @entity453 @entity1 still demonstrated less @entity16894 release, typically 5- to 6-fold less than for ONCAB @entity1 . CONCLUSIONS: The nearly 6-fold reduction of postoperative @entity16894 associated with @entity453 suggests that off-pump surgery may offer superior cardioprotection than coronary artery bypass grafting with conventional cardiopulmonary bypass. \par
