Knee osteoarthritis compromises early mobility function: The XXXX 's Health and Aging Study II.

@entity1 @entity571 @entity158
OBJECTIVE: To examine associations between @entity571 ( @entity571 ) of the knee and early functional limitations in a cohort of high-functioning older @entity1 , and evaluate the contributions of muscle strength, body weight, and @entity158 severity to these limitations. Methods. Cross sectional analyses were conducted on baseline data of the @entity1 's Health and Aging Study II (WHAS II), an observational study of disability transitions in a cohort of @entity1 aged 70-79 upon entry and who were representative of the one-third highest-functioning community-resident @entity1 . Standardized questionnaires and examinations were used to assess knee @entity571 features, medication use, @entity158 severity, knee extensor muscle strength, and body weight. Functional limitation was assessed using validated performance measures and self-report measures of task modification and task difficulty. RESULTS: Sixty-nine @entity1 classified as "symptomatic" for knee @entity571 , 48 with "asymptomatic/intermittently symptomatic," knee @entity571 , and 285 with "no knee @entity571 " were included in the final analysis. Despite selection for their high level of self-reported function, performance was slower and task modification was more frequently reported among @entity1 with knee @entity571 than @entity1 without knee @entity571 . Lower knee extensor strength, higher body weight, and greater @entity158 severity were associated with knee @entity571 , and also with functional limitations. Conclusion. Knee @entity571 appeared to be associated with early functional limitations in this cohort of high-functioning, older, community-resident @entity1 . Lower knee extensor strength, higher body weight, and @entity158 severity were closely associated with these limitations. The extent to which modification of these factors attenuates knee @entity571 associated functional decline should be investigated.
