Changing demographics in REM sleep behavior disorder: possible effect of XXXX and antidepressants.

@entity1 @entity146 @entity1200 @entity179 @entity792 @entity25
BACKGROUND: Rapid eye movement (REM) @entity146 (RBD) has been described predominantly in elderly @entity1 and in association with @entity179 . But an increasing proportion of cases in recent reports and in clinical practice do not fit this description; thus we sought to describe a current RBD population and possibly identify new subgroups with RBD. METHODS: Records of 115 consecutive @entity1 with polysomnogram-confirmed RBD at an @entity25 were retrospectively reviewed. RESULTS: Male to female ratio was 2:1, and 1.25:1 for early-onset (age <50) cases. Mean age at diagnosis was 53.7  16.4years. Most (60%) cases were @entity179 was coincident primarily in older @entity1 . @entity792 was unexpectedly common in @entity1 (20%) particularly in the 30-49 age groups (40%). Antidepressant use was frequent (46.1%), especially in early-onset cases (57.8%). CONCLUSIONS: RBD is diagnosed more equally between @entity1 and @entity1 and in younger individuals than previously reported. While @entity179 is frequently co-incident with RBD in older @entity1 , most @entity1 and early-onset cases have "idiopathic" RBD. High prevalence of @entity792 among @entity1 with RBD suggests an intriguing link between @entity1200 and RBD. A high rate of antidepressant use provides support for a potentially causal role for antidepressants in RBD.
