Prognostic value of @entity11833 , @entity4735 , @entity20319 , and @entity876 single nucleotide polymorphisms in XXXX with early-stage @entity1149 .

@entity1 @entity11833 @entity4735 @entity4557 @entity20322 @entity1149 @entity20319 @entity20315 @entity876 @entity20317 @entity7820
UNASSIGNED: Identification of biomarkers used for the prognostic evaluation of @entity1149 ( @entity1149 ) @entity1 is important. The aim of this study was to evaluate the potential prognostic value of @entity20319 , @entity11833 , @entity4735 , and @entity876 single nucleotide polymorphisms (SNPs) in completely resected @entity1149 @entity1 . In total, 130 @entity1 , surgically treated for @entity1149 between 2000 and 2012, were included. An analysis of SNPs from peripheral blood cells was performed by polymerase chain reaction. @entity20319 @entity20322 , @entity11833 @entity20315 , @entity4735 @entity20317 , and @entity876 @entity7820 polymorphisms were evaluated in conjunction with clinical and pathological parameters and survival. Kaplan-Meier method and Cox regression analysis were used. Median age rate was 59.3, ranging between 36 and 78  years. Median @entity4557 ( @entity4557 ) was found as 46.2  months. In those with @entity4735 CC allele, median @entity4557 was detected as 28.3  months (95  % confidence interval (CI), 20.8-35.8), 46.9  months in those with CT heterozygous (95  % CI, 18.6-75.2), and 80.1  months for those with TT mutant allel (95  % CI, 33.0-127.2). Median @entity4557 was seen to be longer in mutant group and also statistically significant (P   =   0.018). Additionally, upon evaluating CC normal group with CT   +   TT alleles including mutant alleles, median @entity4557 was found as 56.5  months (95  % CI, 24.6-88.4) in CT   +   TT group, and this was statistically significant (P   =   0.005) Also, median @entity4557 was 15.1  months in those including @entity4735 CC allele and 56.5  months in CT   +   TT allele in the group with no adjuvant treatment (P   =   0.001). In conclusion, our study showed that @entity4735 / @entity4735 polymorphism is an independent prognostic factor in operated @entity1149 @entity1 , and these findings should be supported with prospective studies.
