Bilateral adrenalectomy for XXXX : Pros and cons.

@entity1 @entity550 @entity101 @entity6 @entity699 @entity425 @entity701 @entity2014 @entity18184 @entity3427 @entity774
AIM: To assess the outcome of @entity1 undergoing bilateral adrenalectomy for @entity699 ( @entity699 ). METHODS: All @entity1 who underwent bilateral adrenalectomy for @entity699 at the Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences hospital between 1991 and 2013 were included. Medical records were reviewed to obtain @entity1 characteristics and follow-up data. RESULTS: Twenty-seven @entity1 were studied. Mean age was 28.74    12.95 years (range 9-60), male:female ratio was 1.7:1. About half that is, 48.19% were of @entity699 (failed @entity18184 [ @entity18184 ]), 37.04% were of ectopic @entity699 (ECS), and 14.81% were of @entity699 due to bilateral adrenal pathology. Median follow-up period was 80.5 months. Before surgery, 74.1% @entity1 had body mass index > which after surgery declined to <25 in 75% of them. @entity101 was present in 85.2% and after surgery resolved in 40%. @entity6 was present in 44.4% and after surgery resolved in 33% of them. @entity3427 and proximal @entity425 were present in 55.6% and 70.4% @entity1 , respectively, and after surgery improved markedly in all @entity1 . @entity774 developed in 36.3% and @entity2014 in 41.7% @entity1 during follow-up. Three @entity1 died in perioperative period while three succumbed to the disease during follow-up. Two @entity1 developed recurrence of endogenous @entity701 production during the follow-up period. CONCLUSIONS: Bilateral adrenalectomy is a valid treatment option for palliating severe symptoms in Pituitary Cushing's with failed @entity18184 and unlocalized ECS but the procedure is curative for @entity699 due to bilateral @entity550 . Overall morbidity and mortality is higher than other endocrine operations. Co-morbidities tend to be more severe and are a risk factor for mortality during the time @entity1 survives.
