XXXX in @entity712 with normal left ventricular ejection fraction.

@entity1 @entity712 @entity299 @entity4032 @entity67 @entity1002
BACKGROUND: The authors hypothesized that in @entity1 with @entity712 with normal left ventricular (LV) ejection fraction (HFNEF), the same fibrotic processes that affect the subendocardial layer of the left ventricle could also alter the subendocardial fibers of the left atrium. Consequently, these fibrotic alterations, together with chronically elevated LV filling pressures, would lead to both @entity299 of the left atrium (i.e., @entity299 and diastolic function) in @entity1 with HFNEF. METHODS: @entity1 with HFNEF and a control group consisting of asymptomatic @entity1 with LV @entity67 (LVDD) matched by age, gender, and LV ejection fraction were studied using two-dimensional speckle-tracking echocardiography. RESULTS: A total of 420 @entity1 were included (119 with HFNEF and 301 with asymptomatic LVDD). @entity4032 (LA late diastolic strain rate) and diastolic (LA systolic strain and strain rate) function was significantly more impaired in @entity1 with HFNEF (LA late diastolic strain rate, -1.17    0.63 s(-1); LA systolic strain, 19.9    7.3%; LA systolic strain rate, 1.17    0.46 s(-1)) compared with those with asymptomatic LVDD (-1.80    0.70 s(-1), 30.8    11.4%, and 1.67    0.59 s(-1), respectively) (all P values < .0001). On multiple regression analysis, @entity1002 and diastolic strain rate were the most important independent predictors of @entity4032 and diastolic function, in contrast to noninvasive LV filling pressures (i.e., mitral E/e' average septal-lateral ratio), which were modestly related to @entity4032 and diastolic function. Furthermore, in @entity1 with HFNEF, the subendocardial function of both the left atrium and the left ventricle was significantly impaired in high proportions. In that regard, in @entity1 with HFNEF, the rate of @entity299 was 65.5% and 28.5%, whereas the prevalence of @entity1002 was 81.5% and 58%, respectively. In addition, @entity1 with both @entity299 of the left atrium presented worse NYHA functional class as compared with those with normal LA longitudinal function. CONCLUSIONS: In @entity1 with @entity1002 is common and possibly associated with the same fibrotic processes that affect the subendocardial fibers of the left ventricle and to a lesser extent with elevated LV filling pressures. Furthermore, these findings suggest that @entity299 could be related to reduced functional capacity during effort in @entity1 with HFNEF.
