Spermatogonial proliferation and apoptosis in XXXX associated with nonobstructive azoospermia.

@entity1 @entity249 @entity1364 @entity4810 @entity6660
OBJECTIVE: To provide evidence that a pathological process in spermatogonial proliferation and apoptosis may participate in developing @entity6660 of @entity249 @entity1 . DESIGN: Case-controlled retrospective analysis. SETTING: University-based @entity4810 clinic. @entity1 (S): Thirty-four @entity1 with idiopathic @entity6660 . INTERVENTION(S): Collecting blood samples for measurement of hormones and performing testicular biopsy for assessment of spermatogenesis. MAIN OUTCOME MEASURE(S): The expression of @entity1364 ( @entity1364 ) of spermatogonia and the frequency of apoptosis of spermatogonia demonstrated by the in situ DNA 3'-end-labeling method were investigated to determine the degree of cell degeneration. RESULT(S): We could classify 34 @entity249 @entity1 into four subgroups according to spermatogonial proliferation and differentiation. No significant difference in the expression of @entity1364 was demonstrated between these four groups and the control group. In all groups, the balance of spermatogonial proliferation ( @entity1364 -positive rate) to apoptosis was significantly lower than that of the control group. CONCLUSION(S): It was demonstrated that accelerated apoptosis, rather than proliferative dysfunction in the mitotic phase, may induce the decreased number of spermatogonia in @entity6660 . These findings suggest that disorders of the control and regulation of apoptosis may participate in the pathogenesis of idiopathic @entity6660 .
