XXXX : microbiological data and potential adequacy of antimicrobial regimens.

@entity1 @entity2176 @entity1514 @entity55
Adequate antimicrobial therapy is a main approach employed to decrease the mortality associated with @entity55 ( @entity55 ). All methods that optimise empirical treatment without increasing antibiotic selective pressure are relevant. Categorisation of @entity1 according to @entity55 time of onset, severity and risk factors (American @entity1514 Society (ATS) classification) or duration of mechanical ventilation and prior antibiotics (Trouillet's classification) are two such methods. The aim of this study was to catagorise @entity1 with @entity55 according to these classifications and to determine the frequency of resistant pathogens and the most adequate antimicrobial regimens in each group. A total 124 @entity1 with bacteriologically proven @entity55 were studied. The ATS classification categorised @entity1 by increasing frequency of resistant pathogens from 0-30.3%. The ATS empirical antibiotic recommendations appeared valid but proposed combinations including @entity2176 for 72.5% of @entity1 . Trouillet's classification categorised @entity1 into four groups with a frequency of resistant pathogens from 4.9-35.6%. @entity2176 was proposed for 48.5% of @entity1 . The American @entity1514 Society classification appears to be more specific than Trouillet's for predicting the absence of resistant causative pathogens in @entity55 but could lead to a greater use of @entity2176 . Stratification combining the two classifications is an interesting alternative.
