Comparative measurements of @entity519 in @entity1 XXXX using needle electrodes and EF5 binding.

@entity1 @entity66 @entity1313 @entity5 @entity39 @entity26 @entity519 @entity4095
@entity519 is known to be an important prognostic marker in many @entity1 @entity5 . We report the use of two @entity26 measurement techniques in @entity1 @entity1313 and compare these data with semiquantitative histological end points. Oxygenation was measured using the Eppendorf needle electrode and/or EF5 binding in 28 @entity1313 . These data were compared with @entity39 , mitosis, and endothelial proliferation. In some @entity5 , absolute EF5 binding was converted to tissue pO(2) based on in vitro calibrations. Eppendorf electrode readings could not be used to identify WHO grade 1/2 versus WHO grade 3/4 @entity5 , they could not differentiate grade 3 versus grade 4 glial-derived @entity5 , nor did they correlate with @entity39 or endothelial proliferation scores. EF5 binding increased as the @entity5 grade increased and was significantly associated with @entity39 and endothelial proliferation. There was no statistically significant correlation between the two @entity519 detection techniques, although both methods indicated similar absolute ranges of tissue @entity4095 . There was substantial inter- and intratumoral heterogeneity of EF5 binding in WHO grade 4 @entity66 . The majority of cells in glial-derived @entity5 had levels of @entity519 that were mild to moderate (defined herein as 10% to 0.5% @entity4095 ) rather than severe (defined as approximately 0.1% @entity4095 ). Immunohistochemical detection of EF5 binding tracks histological parameters in @entity1313 , with increased binding associated with increasing @entity39 and endothelial proliferation. The proportion of moderately to severely @entity519 cells is relatively low, even in the high-grade @entity5 . @entity1 @entity1313 are dominated by oxic to moderately @entity519 cells.
