Increased blood-brain barrier permeability in @entity2175 demonstrated by XXXX magnetic resonance imaging.

@entity1 @entity2175 @entity101 @entity6 @entity75 @entity73 @entity7241 @entity62 @entity2287
OBJECTIVES: @entity1 with @entity2175 are at increased risk of @entity73 . The retinal and renal complications of @entity6 follow microvascular damage permitting small arterioles to leak, hence the @entity75 might also follow loss of blood-brain barrier (BBB) integrity. Magnetic resonance (MR) brain imaging with intravenous @entity2287 (Gd) diethylenetriamine pentaacetic acid ( @entity7241 ) was used to identify increased BBB permeability. METHODS: Ten well controlled type II @entity6 @entity1 aged 65-70 years and 10 controls underwent MR brain imaging with fluid attenuated inversion recovery (FLAIR); T1 weighted (T1W) volumetric imaging before; and T1W volumetric imaging at 5, 15, 30, 45, 60, and 90 minutes after intravenous @entity7241 . The T1W image before @entity7241 was subtracted from the images at each time point after @entity7241 . Net signal intensity was plotted against time for different brain regions. @entity62 were scored from the FLAIR image. RESULTS: The signal intensity/time curves showed that brain signal intensity increased more in the @entity6 group than controls during the first 15 minutes after @entity7241 , particularly in the basal ganglia (p=0.018). Signal intensity in controls peaked at five minutes and @entity6 at 15 minutes. Subjects with more @entity62 had greater signal increase after @entity7241 , whether @entity6 or not (p=0.001). CONCLUSIONS: Increased BBB permeability with MR imaging was detected in @entity1 with @entity62 . Increased permeability of the BBB might account for some of the cerebral effects of @entity2175 , and so possibly also for the effect of other conditions that affect the microvasculature (like @entity101 ), on the brain.
