Ectopic @entity699 secondary to lung and mediastinal XXXX - report from a tertiary care centre in Iran.

@entity1 @entity5 @entity699 @entity358 @entity151
INTRODUCTION: Ectopic @entity699 (ECS) @entity5 (NETs) of the lung and mediastinum are rarely encountered. In this study, we present our experience in Iran on 15 @entity1 with ECS secondary to lung and mediastinal @entity5 over a period of 27 years. MATERIAL AND METHODS: Since 1985, 15 @entity1 with ECS secondary to lung and mediastinal @entity5 have been diagnosed and prospectively followed by the endocrinology team of Taleghani Hospital, Tehran, Iran. The clinical signs and symptoms, laboratory findings, radiological features, immunohistochemical characteristics, management strategies and outcome data are here presented. RESULTS: There were six @entity1 and nine @entity1 , aged 26-70 years, all presenting with typical features of @entity699 . Based on histopathologic evaluations, four @entity1 had @entity151 ( @entity151 ) and seven @entity1 had pulmonary NETs, one @entity1 had a thymic NET, and one case was diagnosed as a @entity358 . The mean    SD serum cortisol, 24h urine free cortisol and plasma ACTH were 47.2    20.5  g/dL, 2,702    5,439  g/day, and 220    147 pg/mL, respectively. @entity358 ranged in diameter from 1.1 to 4 cm (mean 1.9    1.1 cm). One @entity1 had a 10 cm mediastinal mass. The duration of follow up in these cases was between one month and seven years (mean 29.9    27.5 months). The four @entity1 with @entity151 died within three months of diagnosis. CONCLUSION: Our data demonstrates the protean clinical and laboratory manifestations of ECS secondary to lung and mediastinal @entity5 , the problems encountered in diagnosis, and the need for a multidisciplinary approach. This study confirms other series from Western Europe and North America that, unlike the @entity151 @entity1 who show a poor outlook, ECS @entity358 has a more favourable prognosis.
