Genome-wide association study of motor coordination problems in XXXX identifies genes for brain and muscle function.

@entity1 @entity72801 @entity19 @entity71 @entity72800 @entity1897 @entity4531 @entity746
OBJECTIVES: Motor coordination problems are frequent in @entity1 with @entity71 ( @entity71 ). We performed a genome-wide association study to identify genes contributing to motor coordination problems, hypothesizing that the presence of such problems in @entity1 with @entity71 may identify a sample of reduced genetic heterogeneity. METHODS: @entity1 with @entity71 from the International Multicentre @entity71 Genetic (IMAGE) study were evaluated with the Parental Account of @entity1 's Symptoms. Genetic association testing was performed in PLINK on 890 probands with genome-wide genotyping data. Bioinformatics enrichment-analysis was performed on highly ranked findings. Further characterization of the findings was conducted in 313 Dutch IMAGE @entity1 using the Developmental Coordination Disorder Questionnaire (DCD-Q). RESULTS: Although none of the findings reached genome-wide significance, bioinformatics analysis of the top-ranked findings revealed enrichment of genes for @entity1897 and @entity746 . Genes involved in neurite outgrowth and muscle function were also enriched. Among the highest ranked genes were @entity72800 , involved in @entity4531 , and @entity72801 , causing motor coordination problems in @entity19 . Further characterization of these findings using DCD-Q subscales found nominal association for 15 SNPs. CONCLUSIONS: Our findings provide clues about the aetiology of motor coordination problems, but replication studies in independent samples are necessary.
