Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and XXXX -related functions.

@entity1249 @entity303 @entity2730 @entity5019 @entity148 @entity35 @entity5591 @entity2414
Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant @entity303 . However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the @entity1249 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental @entity35 model of @entity303 . @entity35 with @entity5591 -induced @entity2730 were assessed in the object location task with different DBS parameters. Moreover, @entity148 -related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied @entity5019 immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and @entity1249 sub-region was able to restore @entity2414 when a specific set of stimulation parameters was used. No @entity148 -related side effects were found following DBS. The beneficial behavioral performance of @entity1249 DBS @entity35 was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute @entity1249 DBS restores @entity2414 possibly through improved attentional and cognitive processes in the limbic cortex.
