@entity2252 XXXX genotype interacts with childhood adversity and influences the formation of hippocampal subfields.

@entity1 @entity308 @entity3729 @entity1399 @entity41520 @entity2252 @entity32862 @entity2596 @entity14691 @entity130
Childhood stress and genetic factors like the @entity14691 polymorphism of the @entity2252 ( @entity2252 ) gene are associated with a higher risk for developing @entity308 ( @entity308 ) and might also influence hippocampal changes. The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in @entity308 compared to healthy controls and which subfields are affected by the @entity2252 @entity14691 polymorphism and @entity1 adversity. Adult @entity1 with @entity308 and healthy matched controls underwent high-resolution magnetic resonance imaging. Automatic segmentation using the programme FreeSurfer was used to segment the hippocampal subfields dentate gyrus (DG/ @entity3729 ), @entity1399 and @entity41520 . The history of possible childhood adversity was assessed using the Childhood @entity130 Questionnaire and the @entity14691 @entity2252 SNP ( @entity32862 ) genotypes were obtained. @entity1 with @entity308 had significantly smaller @entity3729 /DG and @entity41520 volumes compared to healthy controls. Furthermore, there was a significant interactive effect of @entity2252 allele and childhood adversity on @entity41520 and @entity3729 /DG volumes. Met allele carriers without childhood adversity had larger and with childhood adversity smaller @entity3729 /DG and @entity41520 volumes than @entity2596 -allele homozygotes. Our results highlight stress by gene interactions as relevant for hippocampal volume reductions, in particular for the subfield @entity41520 and dentate gyrus. Hum Brain Mapp 35:5776-5783, 2014.    2014 Wiley Periodicals, Inc.
