Role of @entity1199 and interferon in the generation of natural cytotoxic activity in @entity683 virus-stimulated PBL cultures: analysis with the use of XXXX .

@entity1199 @entity683 @entity379 @entity617
We have examined the role of @entity1199 , @entity379 and interferon-alpha in the generation of natural cytotoxic (NC) activity and cytotoxic T-lymphocyte (CTL) activity in peripheral blood lymphocyte cultures stimulated with @entity683 virus, using the immunosuppressive effects of @entity617 . In addition to an inhibitory effect on the generation of CTL activity, @entity617 also inhibited the generation of NC activity in a similar dose-and time-dependent manner. @entity617 suppressed the production of @entity379 when it was added on the first day of culture of PBL with @entity683 virus. Levels of interferon-alpha were not affected. The effects of @entity617 on the generation of NC activity and CTL activity in kinetic terms were not paralleled by the effects on interferon-alpha and @entity379 production. The diminished generation of NC activity could be reversed by the addition of @entity1199 ( @entity1199 ), but @entity379 had little if any restorative effects. Interferon-alpha had no effect. These findings support the hypothesis that @entity1199 is the major inducer of NC activity in CTL generation cultures. The inhibitory effect on CTL generation could only be reversed by @entity1199 and not by interferon-alpha- and @entity379 . Thus, in the absence of @entity1199 , interferon-alpha and @entity379 cannot support the generation of CTL activity or the concomitantly induced NC activity.
