Effect of pentobarbital anesthesia on renal sympathetic nerve activity in the XXXX .

@entity4485 @entity8 @entity95 @entity591 @entity551 @entity1168
The effects of @entity4485 (PB) anesthesia on arterial pressure, heart rate, and @entity8 ( @entity8 ) were studied in chronically instrumented intact @entity95 and @entity95 with sinoaortic baroreceptor denervation (SAD). In intact @entity95 , PB caused an initial decrease in mean arterial pressure from 82 +/- 2 to 42 +/- 5 mm Hg, which then returned to the control level within 5 min. @entity8 increased by 144 +/- 19% in response to @entity551 induced by PB then also returned to the control level within 5 min. Heart rate increased by 56 +/- 10 from 244 +/- 11 beats/min and remained elevated for 60 min. Sensitivities of baroreflex control of heart rate and @entity8 were markedly impaired by PB anesthesia. In SAD @entity95 , PB caused @entity551 (-46 +/- 5 mm Hg), which lasted for 15 min. @entity8 decreased initially by 80 +/- 5%, then gradually returned toward the control level. However, at 45 min after injection of PB, @entity8 was still depressed significantly. @entity591 induced by PB was abolished by SAD, i.e. heart rate actually decreased by 53 +/- 10 beats/min. These results suggest that in intact @entity95 steady-state effects of PB were: no change in mean arterial pressure or @entity8 , and @entity591 , all due to baroreflex compensation. However, in the absence of baroreflex compensation, PB elicited @entity551 , @entity1168 , and a decrease in @entity8 .
