Pharmacokinetics of lopamidol after intrathecal administration in XXXX .

@entity1 @entity1496 @entity3990
The kinetics of @entity3990 , a new nonionic radiocontrast agent, were evaluated in 10 @entity1 undergoing lumbar myelography. The doses of @entity3990 administered intrathecally were 11 and 15 ml of a 200-mg @entity1496 per ml solution in one and nine @entity1 , respectively. Radiographs were made within 30 to 40 min and CTs were taken at about 1, 6, and 23 hr after @entity3990 administration. The diagnostic quality and usefulness of the conventional and CT myelograms were considered excellent. In the lumbosacral subarachnoid space, the densitometry CT readings were maximal at 1 hr, whereas in the cervical subarachnoid space, peak CT values were reached at 6 hr. Plasma and urine samples were taken at frequent intervals up to 48 hr after the contrast agent was administered. Peak plasma levels of @entity3990 were observed at 2.9 hr and were no longer detectable at 48 hr. The 48-hr urinary recovery for all @entity1 averaged 66 +/- 8% of the dose. In all but one @entity1 , @entity3990 was cleared almost completely from the CSF within 24 hr. Side effects after @entity3990 administration were transient and minor, and were not related to the CT readings or its systemic clearance.
