[Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of XXXX according to a case report].

@entity1 @entity1375 @entity308 @entity5320 @entity5079 @entity4433 @entity5322 @entity2621 @entity1955 @entity3756
Little is known about how psychotropic drugs influence thyroid function in @entity1 , but it has been reported that @entity3756 decreases the efficacy of @entity1955 in @entity1 treated for @entity1375 . Most psychotropic drugs are metabolized in the liver by cytochrome P450. @entity3756 is metabolized by cytochrome P450 @entity5320 , @entity5322 , and @entity4433 . @entity5079 is metabolized by @entity5320 , and to some extent also by @entity5322 . Since both substances, at least in part, are metabolized by the same liver enzymes, drug interactions can be expected. In this article we describe such a possible interaction between @entity3756 and @entity5079 in a @entity1 treated with @entity1955 for @entity1375 ( @entity2621 ). She displayed both clinical symptoms and laboratory data typical of @entity1375 when long-term antidepressive @entity3756 therapy (100 mg/day) was transiently supplemented with @entity5079 (30 mg/day). All symptoms and signs of @entity1375 disappeared completely when the @entity5079 treatment was discontinued. These findings imply that unexpected drug effects may occur in @entity308 @entity1 with @entity1375 if they are treated with both @entity3756 and @entity5079 . In such situations thyroid function should be checked carefully.
