[Clinical and immunologic results of immunotherapy with pooled buffy coat transfusions in females with XXXX ].

@entity1 @entity2208 @entity7992 @entity17374
In a multicenter study we have evaluated the effect of immunotherapy with pooled buffy coats on @entity1 with @entity7992 . 21 @entity1 were selected under the same criteria with respect to clinical, immunological and blood banking conditions. All @entity1 have had at least two miscarriages with the same partner and no living @entity1 (except one case). Additionally, all well-known reasons for abortions were excluded. The couples were tested for @entity17374 antigens as well as for the presence of HLA-antibodies. The couples with recurrent @entity2208 suggested a significantly higher compatibility in two or more antigens in comparison to the control couples with @entity1 and without any abortion. Before treatment there was no case with cytotoxic HLA antibodies. 10 @entity1 received each two pooled buffy coats intravenously before pregnancy at time intervals of 3 weeks. 15 @entity1 were treated in early pregnancy until the 28th week of gestation at the same application intervals. In the meantime 10 of 15 @entity1 have delivered at term a healthy and mature @entity1 with normal weight. Four of 15 are still pregnant in the third trimester of pregnancy. In one case the pregnancy resulted in an abortion. The buffy coat transfusions were well tolerated and led in no case to the formation of antierythrocytic antibodies. 12 of 21 @entity1 treated developed HLA antibodies at various time intervals during immunotherapy, mainly with a low titre. In 7 of 10 cases the antibodies occurred in the treatment period before pregnancy, in 5 of 15 cases during pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
