A Multi-Component Model of XXXX .

@entity5 @entity978 @entity137
@entity978 is an example for a @entity5 with an extremely tight interaction of @entity5 cells with cells from the @entity5 micro-environment. These so-called bystander cells are not inert but interact actively with the @entity5 cells. Some of these cells support @entity5 growth by delivery of co-stimulating and anti-apoptotic signals ("helper cells"). Other cells ("killer cells") are involved in the anti- @entity5 immune response which is obviously not efficient enough for @entity5 elimination. The activity of both helper cells and killer cells is regulated by additional cells in the stroma ("regulatory cells"). The dynamic behavior of such multi-component systems is difficult to predict. In the present paper we propose a model that can be used for simulation of essential features of this system. In this model, @entity5 growth depends on (i) presence of few @entity5 stem cells, (ii) co-stimulation of @entity5 cells by the @entity5 stroma, (iii) activity of regulatory cells that suppress killer cells without suppression of helper cells. The success of cytotoxic/cytostatic therapy in this model varies depending on the therapy-related @entity137 for each of the cell populations. The model also allows the analysis of immunotherapeutic interventions. Under certain conditions, paradox enhancement of @entity5 growth can occur after therapeutic intervention. The model might be useful for the design of new treatment strategies for @entity978 and other @entity5 with prominent @entity5 -stroma interaction.
