[Simultaneous radio- and chemotherapy of XXXX of the esophagus].

@entity1 @entity1138 @entity957 @entity3 @entity1487
Between 1983 and 1986, 41 @entity1 with a @entity957 without hematogenic @entity3 were treated with a combination of radio- and chemotherapy preoperatively. Treatment consisted of @entity1138 (10 mg/sqm/day 1) and continuous infusion of 5 @entity1487 (1000 mg/sqm/day-day 1 to 4) with a maximum of 1500 mg per day. On day 2 radiotherapy was started. After the administration of 36 Gy all @entity1 were restaged. Nine @entity1 were referred to surgery. In 13 cases surgery was refused, because of inoperability, due to local or distant @entity3 . In these @entity1 radiotherapy was continued up to 50 to 60 Gy for palliation. Although the disease was confined to the oesophagus no surgery was performed in 19 @entity1 , because of age, enhanced risk of anaesthesia or refusal by the @entity1 . These @entity1 were treated with radiotherapy alone (60 Gy) with curative intention. 32 @entity1 treated without surgery were followed up. For the @entity1 treated with curative intent, the one year survival rate was 62%, the two year survival rate was 42%. Compared to a group treated in 1970 bis 1982 with the same dosage of irradiation without the combination of chemotherapy the median survival could be raized from nine to 24 months, the two year survival rate improved from 18% to 42%. @entity1 treated for palliation only did not survive the first year after therapy.
