Comparison of inflammatory and systemic sources of growth factors in acute and chronic XXXX wounds.

@entity1 @entity40649 @entity32 @entity1356 @entity7 @entity73 @entity442 @entity2533
Inflammatory cells are generally assumed to be the primary source of most growth factors/cytokines that participate in wound healing. Correspondingly, most attempts to enhance wound healing have been directed at the wound itself. However, certain key factors such as @entity442 ( @entity442 ) and related proteins are present in blood in sufficient quantities to suggest significant contributions from outside the wound. Because little is known of the dynamics of IGF family members in wounds, particularly in @entity1 wounds, we serially measured the mRNAs and proteins of the IGF family in fluid and tissues taken from acute as well as chronically inflamed @entity1 wounds and compared them to their corresponding concentrations in blood. We also measured @entity40649 , @entity7 , @entity1356 , matrix metalloproteinases and selected isomers/receptors, all of which are associated with @entity32 . All IGF proteins reached their highest concentrations immediately after injury. No difference between @entity442 mRNA expression between acute and inflamed wounds was found. As a group, IGF-related proteins, in contrast to @entity2533 , @entity7 , and @entity1356 , are highly correlated to and are generally below their concentrations in blood and are not elevated by @entity32 . The IGF family therefore appears to enter wounds, even inflamed wounds, mainly from blood. If blood @entity442 is low, wound levels are lower. This data suggests that @entity73 due to @entity442 deficiency can be readily detected and is, at least in part, easily and safely correctable.
