Impact of Skin XXXX Associated with Targeted Cancer Therapies on Body Image: A Prospective Study.

@entity1 @entity137 @entity308
BACKGROUND AND OBJECTIVE: Body-image issues associated with dermatological side effects induced by anticancer-targeted therapies have not been specifically explored until now despite growing literature about their impact on quality of life. Prospective and longitudinal investigations were needed. The aim of our study was to describe body-image changes occurring with cutaneous @entity137 and their psychosocial impact on @entity1 . @entity1 AND METHODS: Thirty-three @entity1 were evaluated four times during the first 3  months of targeted therapy in terms of body satisfaction, physical attitudes and @entity308 with validated and ad hoc questionnaires. The NCI-CTCAE V4.0 was used to grade adverse dermatological events. Descriptive and inferential analyses were conducted with SPSS 14.0 software. RESULTS: Ninety-four per cent of the @entity1 developed @entity137 . Body satisfaction remained stable and slightly better than average over this period. About one-third of the @entity1 reported body-image issues at baseline. Body satisfaction and @entity308 levels at baseline appeared to be significantly associated with body-image issues after 3  months of therapy. CONCLUSION: In the framework of regular dermatological monitoring, @entity137 did not appear to be associated with body-image issues. Body satisfaction and depressive symptoms at the beginning of targeted therapy emerged as critical factors that practitioners should consider in order to prevent deterioration of body image that could impact on quality of life and compromise compliance.
