XXXX of the upper aerodigestive tract in nonusers of @entity286 .

@entity1 @entity286 @entity146 @entity5 @entity75 @entity957 @entity1442
Nine hundred forty-five @entity1 with @entity957 of the upper aerodigestive tract (SCC-UADT) were treated at three University of Louisville-affiliated hospitals from 1970 through 1979. Retrospective analysis disclosed that 33 @entity1 (3.4%) never used @entity286 . This group offers interesting contrasts to the more prevalent @entity286 -related epidermoid @entity5 . Cancers in nonusers of @entity286 (mean age, 68 years) occurred approximately 10 years later than most epidermoid UADT @entity5 . @entity1 predominated with a ratio of 2.7 to 1. Fifteen of 16 @entity1 (94%) older than 70 years were @entity1 . Twenty-four of 33 primary lesions (72%) were in the oral cavity and two thirds of these were staged 0, I, and II (American Joint Commission [AJC]). Of the @entity1 younger than 70 years of age, 42% were @entity1 , 42% had non-oral primaries, and most (74%) had @entity1442 in AJC Stages III and IV. Second squamous cell primaries of the UADT developed in 6 of the 33 @entity1 (18%) with an average of 48 disease-free months. Five of six were @entity75 in @entity1 with original oral primaries. Of the 16 @entity1 older than 70 years with small, localized @entity5 , conservative surgery failed in 9 (56%). Although 4 were salvaged by re-excision or radiation, 5 of these 16 @entity1 in AJC Stage 0, I, and II died of this @entity5 (32%). The tendency for conservative initial surgical treatment in older @entity1 is believed to be responsible for the higher than expected rate of treatment failure. An @entity146 approach is recommended and further supported by the complete absence of surgical mortality in this group of @entity1 .
