15-year Experience of 18F-FDG PET Imaging in Response Assessment and Re-staging after Definitive XXXX .

@entity1 @entity3852 @entity8984 @entity419
OBJECTIVES: To evaluate the utility of @entity419 PET in re-staging and response assessment of @entity1 who underwent definitive treatment for @entity3852 ( @entity3852 ). METHODS AND MATERIALS: A retrospective review of @entity1 undergoing @entity8984 -FDG PET imaging for @entity3852 between January 1997 and October 2010 at the Peter MacCallum Cancer Centre with follow-up until February 2015 was performed. Data analysis was performed on @entity1 who were treated definitively and had post treatment PET imaging performed either as a re-staging scan for ongoing monitoring, suspicion of recurrence or assessment for suitability of salvage treatment or for response assessment within 1-6 months of treatment. Management plans were recorded prospectively prior to @entity419 PET imaging and compared to post imaging management to assess impact of the study as per our previously defined categories: "high" if the primary treatment modality or intent was changed; "medium" if the radiotherapy technique or dose was altered. In total, 62 @entity1 were included in the analysis. Thirty-six @entity1 had 53 restaging scans and 37 @entity1 had a response assessment scan. The median follow up of @entity1 in the re-staging group was 5.3 years (95% CI [4.6-9.4]), while it was 5.7 years (95% CI [4.3-10.8]) in the response assessment group. RESULTS: Re-staging @entity419 PET scans had a high impact in 24 of 53 cases (45%) and a medium impact in 6 of 53 cases (11%). In the response assessment group, 24 of 37 @entity1 had a complete metabolic response (CMR). @entity1 without a CMR had a 15% 1-year overall survival (95% CI 0.04-0.55). Those with a CMR had an 88% 2-year overall survival (95% CI 0.75-1.00) and a 68% 5-year overall survival (95% CI 0.49-0.95). Presence of a CMR (p<0.001) and nodal involvement (P = 0.016) were statistically significant prognostic factors for overall survival. CONCLUSION: @entity419 PET imaging had a high impact on restaging following definitive treatment in @entity1 with @entity3852 . Metabolic response was significantly associated with overall survival. @entity419 PET may play an important role in ongoing post treatment management of @entity3852 .
