Niosome as a drug carrier for topical delivery of XXXX .

@entity33756 @entity3954 @entity33414 @entity74 @entity37977 @entity35
Niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. The topical form of @entity3954 (NAG) recently has been considered in the treatment of @entity74 due to its inhibitory effect on thyrosinase enzymes in melanocytes. To improve NAG penetration into the skin we formulated the drug in niosomes and investigated its flux across excised @entity35 skin using Franz diffusion cells. The drug assay was performed by a novel and specific high performance liquid chromatography method. Niosomal vesicles were further characterized by optical and scanning electron microscopy and particle size analysis. Niosomes prepared with @entity33414 produced a drug encapsulation of about 50%. The vesicle size was markedly dependent on the composition of the niosome formulations and was in range of 500-4500 nm ( @entity37977 < @entity33756 < @entity33414 niosomes). @entity33414 -niosomes provided a higher NAG flux across the skin than @entity33756 - and @entity37977 -nisomes. All formulations significantly improved the extent of drug assessed to be localized in the skin (P< 0.05), as compared to NAG hydroalcoholic (HA) solution. Our study demonstrated the potential of niosomes for improved NAG localization in the skin, as needed in @entity74 .
