Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE XXXX Homozygotes.

@entity1 @entity69 @entity14399 @entity68
UNASSIGNED: Objectives. We aimed to examine whether baseline hemoglobin levels in @entity14399 -homozygous @entity1 are related to the degree of serum ferritin (SF) elevation and whether @entity1 with different baseline hemoglobin have different phlebotomy requirements. Methods. A total of 196 @entity1 (124 males and 72 females) who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study. Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (>= 150   g/L) baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve @entity68 depletion than those who had lower (<150   g/L) baseline hemoglobin, regardless of whether baseline SF was below or above 1000     g/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for @entity69 saturation between male subgroups with SF above 1000     g/L. Similar differences were observed when females with higher (>= 138   g/L) baseline hemoglobin were compared with those with lower (<138   g/L) baseline hemoglobin. Conclusion. Dividing @entity14399 -homozygous @entity1 into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations.
