Effect of asymptomatic vaginal colonization with XXXX on pregnancy outcome.

@entity1 @entity1449 @entity3152 @entity7553 @entity5132 @entity281 @entity6981
INTRODUCTION: @entity281 is a major causative factor of @entity3152 . The present study was performed to evaluate the effect of asymptomatic vaginal colonization with @entity5132 at early gestation on pregnancy outcome. MATERIAL AND METHODS: From 2005 to 2014, a total of 8447 @entity1 with singleton pregnancies between 10(+0) and 16(+0) gestational weeks were routinely subjected to an antenatal @entity281 screen-and-treat program. Vaginal smears were Gram-stained and microscopically evaluated, and data were retrospectively analyzed. @entity1 exposed to Candida received @entity1449 and were re-tested after 4-6 weeks. Treatment was repeated in case of recurrence. @entity1 with normal or intermediate vaginal flora were considered as non-exposed. @entity6981 and trichomoniasis were assessed and treated as well. Descriptive data analysis, chi-squared testing and multiple regression analysis with adjustment for potential confounders were performed. Rates of asymptomatic @entity281 , @entity3152 and low birthweight served as the main outcomes measures. RESULTS: A normal or intermediate flora was found in 6708 (79.4%) of the screened @entity1 ; 1142 @entity1 (13.5%) showed asymptomatic @entity5132 @entity281 . Of this group, 185 @entity1 (2.2%) had a recurrence of Candida on vaginal smears. Compared with the non-exposed @entity1 with normal or intermediate flora, those with recurrent @entity7553 had higher rates of @entity3152 (11.9% vs. 9.5%) and of low birthweight (10.8% vs. 8.0%), as confirmed in the multiple model (p = 0.02). CONCLUSIONS: Recurrent asymptomatic vaginal colonization with Candida in early pregnancy is associated with @entity3152 and low birthweight. Routine screening and consequent treatment for @entity7553 could improve pregnancy outcomes.
