163   Submaximal Angioplasty for Symptomatic XXXX A Prospective, Phase I Study.

@entity1 @entity407 @entity64 @entity455 @entity101 @entity548 @entity6 @entity4905 @entity1031 @entity4522 @entity453 @entity850 @entity204 @entity385
INTRODUCTION: @entity4522 ( @entity4522 ) accounts for approximately 10% of @entity385 . The recent SAMMPRIS study displayed a high incidence of perioperative complications (15%) for treatment of @entity4522 with stenting. Although the incidence of @entity64 was lower in the medical arm, recurrent @entity64 was found in 12% of @entity1 despite aggressive medical management, suggesting that intervention may remain a viable option for @entity4522 if perioperative risk is minimized. Angioplasty without stenting represents an alternative and understudied revascularization treatment for @entity4522 . Submaximal angioplasty limits the @entity1031 risk, vessel perforation, and reperfusion @entity548 . We conducted a prospective phase I trial designed to assess the safety of submaximal angioplasty in @entity1 with symptomatic @entity4522 . METHODS: This study was approved by the local institutional review board. Demographic and clinical data were prospectively collected. Angioplasty was performed for @entity1 with symptomatic @entity4522 (significant- @entity850 =70%) with a balloon undersized to approximately 50% to 70% of the nondiseased vessel diameter. The primary outcome measure was the incidence of periprocedural complications (combined rate of @entity204 , @entity64 , and @entity548 occurring within 30 days and at 1 year). RESULTS: Among 65 @entity1 screened with symptomatic @entity4522 , 24 had significant angiographic @entity850 that met the inclusion criteria of this study. Mean age was 64.08 years (median 65 years; standard deviation + 11.24), most were @entity1 (62.5%), and most were white (66.67%). Many @entity1 had @entity455 concomitants, including @entity101 (95.8%), @entity407 (70.83%), smoking history (54.1%), and @entity6 (45.8%). @entity453 (37.33%) and previous @entity64 or @entity4905 (45.83%) were present frequently. Most @entity1 (75%) had anterior circulation @entity850 . The mean preprocedure @entity850 was 80.16% (median 80%, range 70%-95%). Successful angioplasty was performed in all @entity1 , with a mean postangioplasty @entity850 of 54.62% (median 55.5%, range 31%-78%). Rates of @entity385 in the territory of the treated artery were 0% within 30 days and 5.55% (in the only @entity1 who presented with restenosis) at 1 year. The mortality and @entity548 rate was 0%. CONCLUSION: Submaximal angioplasty for symptomatic @entity4522 is a safe and effective technique. None of the @entity1 had @entity385 in the first 30 days, and only 1 @entity1 presented with symptomatic restenosis leading to @entity385 during 1 year of follow-up.
