XXXX : incidence increases from 12 to 30 to 60 months.

@entity1 @entity0 @entity4 @entity4269 @entity13185
@entity0 survivors are at life-time risk of developing @entity4269 ( @entity4269 ). Quantification of @entity4269 has been problematic as the criteria used to identify @entity4269 use various methods to assess changes in the volume of the affected limb. In part because of difficulties and variability in measurement and diagnosis, the reported incidence of @entity4269 varies greatly among @entity1 treated with surgery and radiation for @entity0 . The goal of this research was to describe the trends for @entity4269 occurrence over three points in time (12, 30, and 60 months) among @entity0 survivors using four diagnostic criteria based on three measurement techniques. @entity1 were enrolled following diagnosis of @entity0 but before surgery. Baseline limb volume and symptom assessment data were obtained. @entity1 were followed every 3 months for 12 months, then every 6 months thereafter for a total of 60 months. Limb volume changes (LVC) in both limbs were measured using three techniques: objectively by (a) circumferences at 4 cm intervals and (b) perometry and subjectively by (c) symptom experience via interview. Four diagnostic criteria for @entity4269 most often reported in the literature were used: (i) 2 cm circumferential change; (ii) 200 mL perometry LVC; (iii) 10% perometry LVC; and (iv) @entity13185 ( @entity13185 ) report of limb heaviness and @entity4 , either 'now' or 'in the past year' (diagnostic criteria i-iii define increases/differences in limb volume from baseline and/or between the affected and non-affected limb). Standard survival analysis methods were applied to identify when the criteria corresponding to @entity4269 were met. Trends in @entity4269 occurrence are reported for preliminary analysis of data from 236 @entity1 collected at 6-, 12-, 18-, 24-, 30-, and 60-months post-op. At 60 months post-treatment, @entity4269 incidence using the four criteria ranged from 43% to 94%, with 2 cm associated with the highest frequency for @entity4269 occurrence and @entity13185 the lowest. Sixty-month trends are compared to earlier trends at 12- and 30-months, per criterion. These preliminary findings provide additional evidence that @entity0 survivors are at risk for developing @entity4269 beyond the first year following treatment. Cases of @entity4269 continue to emerge through 60-months post- @entity0 surgery. This 60-month analysis supports the previous 12- and 30-month analyses in finding the 2 cm criteria to be the most liberal definition of @entity4269 . The self-report of heaviness and @entity4 , along with 10% LVC, represent the most conservative definitions (41% and 45%, respectively). Furthermore, the variety of criteria used to identify @entity4269 , along with the absence of baseline (pre-treatment) measurements, likely contribute to the wide range of @entity4269 incidence rates reported in the literature.
