MRI Susceptibility Changes Suggestive of @entity68 Deposition in the Thalamus after XXXX .

@entity1 @entity64 @entity2806 @entity1188 @entity528 @entity68 @entity385
BACKGROUND: @entity68 accumulation has been linked to @entity528 following @entity2806 . In animals, a hypointense signal on T2*-weighted (T2*-w) MRI correlated with @entity68 deposits in remote brain regions following @entity385 . We aim to assess whether such signal changes are present in remote brain structures following @entity385 in @entity1 . METHODS: We analyzed T2*-w images of 36 @entity1 with unilateral @entity385 and 36 healthy controls. Regions of interest (ROIs) consisted of the thalamus, putamen, globus pallidus, caudate nucleus and white matter. To quantify signal intensity in ROIs ipsilateral to the @entity1188 , signal intensity was measured in the ROIs in both hemispheres and a ratio of signal intensity was calculated. Signal asymmetry was compared between @entity1 and controls and its relation with time after @entity64 onset was assessed. RESULTS: In 34 (94%) @entity1 , the thalamus ipsilateral to the @entity1188 was hypointense compared to the contralateral thalamus. Ipsilateral thalamic signal hypointensity was significantly different between @entity1 and controls (p < 0.001) and was present as early as 1 day after @entity64 onset. In other ROIs, no difference was found between @entity1 and controls. No association was found between intensity asymmetry and time. CONCLUSION: We demonstrated that, as early as days after @entity385 , T2*-w signal intensity was decreased in the ipsilateral thalamus. This finding might indicate pathophysiologic changes in regions outside the infarcted area, possibly reflecting toxic @entity68 accumulation.
