The revised German XXXX Questionnaire: validation of a disease-specific health-related quality of life instrument.

@entity1 @entity1577
BACKGROUND: The assessment of health related quality of life (HRQOL) has increasingly been recognized as an important adjunct to medical outcome parameters in the monitoring of @entity1577 ( @entity1577 ) @entity1 and in clinical studies. The @entity1577 Questionnaire (CFQ) is a disease-specific HRQOL instrument for @entity1577 @entity1 developed in France. Translations are currently being validated in four different countries. The aim of the present study was to validate the German adaptation of the CFQ-14+. METHOD: On the basis of results from a first dataset (n = 197 @entity1577 adolescent and adult @entity1 ), revisions were made and retested in a second sample of 103 @entity1 . RESULTS: The final revised version showed good construct validity. The same nine HRQOL domains as in the French original CFQ-14+ emerged from the analyses as structurally robust scales. The internal consistencies of the HRQOL scales ranged from 0.71 to 0.94. The instrument's clinical validity was supported by severely ill @entity1 reporting lower HRQOL than less severely ill @entity1 on most scales. CONCLUSION: We conclude that the evidence supports the validity and reliability of the instrument. An important future area of application is the use in comparative multi-center international studies.
