Pretreatment with @entity2399 protects against hypoxic-ischemic brain injury but postasphyxial treatment worsens XXXX in seven-day-old @entity35 .

@entity1568 @entity2399 @entity353 @entity63 @entity75 @entity26 @entity1711 @entity1010 @entity519 @entity1710 @entity35 @entity528 @entity1760
OBJECTIVE: Our purpose was to study the neuroprotective effect of @entity2399 on hypoxicischemic @entity75 and how the timing of @entity1760 administration changes its effect in the newborn @entity35 . STUDY DESIGN: Seven-day-old @entity35 (n = 91) were exposed to unilateral carotid artery ligation followed by 2 hours of @entity519 (8% @entity26 in 92% @entity1568 ). @entity2399 (270 mg/kg) was intraperitoneally administered 30 minutes before (pretreatment) or 30 minutes after (posttreatment) the 2 hours of @entity519 . In each experiment equivalent amounts of saline solution were administered as controls. Seven days after the injury the @entity35 were killed and the brains were removed for histologic study with @entity1710 and @entity1711 staining. The severity of @entity1010 and @entity528 was evaluated in the cerebral cortex and hippocampus and compared by chi2 test between the @entity1760 group and the controls. RESULTS: Ionized @entity1760 concentrations were significantly increased from 0.52 +/- 0.02 mmol/L to 1.38 +/- 0.07 mmol/L at 0.5 hour after injection and thereafter gradually decreased to 0.73 +/- 0.07 mmol/L at 3.5 hours. @entity1760 significantly reduced the incidence of @entity353 (0% in @entity1760 vs 29% in controls) and protected the cerebral cortex from @entity528 (the incidence of normal, mild, moderate, and severe @entity528 was 48%, 29%, 5%, and 19% in @entity1760 and 30%, 5%, 25%, and 40% in controls, respectively) in the pretreatment group. In the posttreatment group @entity1760 caused increased @entity528 compared with the controls. CONCLUSION: @entity2399 has neuroprotective effects against @entity519 - @entity63 . This effect is restricted to the pretreatment group in which @entity2399 is administered before the insult.
