A @entity12069 -comparative proteomic approach identifies regulatory changes triggered by XXXX .

@entity1568 @entity3505 @entity14472 @entity281 @entity1892 @entity12069 @entity5261 @entity367 @entity4664
UNASSIGNED: Plant pathogens face different environmental clues depending on the stage of the @entity281 cycle they are in. @entity12069 infects small grain cereals producing @entity14472 @entity1892 ( @entity1892 ) that act as virulence factor in the interaction with the plant and have important food safety implications. This study addresses at the proteomic level the effect of an environmental stimulus (such as the presence of a @entity4664 like @entity5261 ) possibly encountered by the fungus when it is already within the plant. Because biological diversity affects the proteome significantly, a multistrain (n=3) comparative approach was used to identify consistent effects caused on the fungus by the @entity1568 source ( @entity5261 or @entity367 ). Proteomics analyses were performed by the use of 2D-DIGE. Results showed that @entity5261 augmented @entity1892 production but not equally in all strains. The @entity4664 reshaped drastically the proteome of the fungus activating specific pathways linked to the translational control within the cell. Chromatin restructuring, ribosomal regulations, protein and mRNA processing enzymes were modulated by the @entity5261 stimulus as well as metabolic, structural and virulence-related proteins, suggesting the need to reshape specifically the fungal cell for @entity1892 production, a key step for the pathogen spread within the spike. BIOLOGICAL SIGNIFICANCE: Induction of toxin synthesis by plant compounds plays a crucial role in toxin contamination of food and feed, in particular @entity14472 @entity1892 produced mainly by @entity12069 on @entity3505 . This work describes the level of diversity of 3 strains facing 2 toxin inducing plant derived compounds. This knowledge is of use for the research community on toxigenic Fusarium strains in cereals for understanding the role of fungal diversity in toxin inducibility. This work also suggests that environmental clues that can be found within the plant during @entity281 (like different @entity1568 compounds) are crucial stimuli for reshaping the proteome profile and consequently the specialization profiling of the fungus, ultimately leading to very different toxin contamination levels in the plant.
