A case of XXXX associated with IgG4-related disease.

@entity1 @entity2347 @entity5 @entity7841
INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. We present a case of @entity2347 ( @entity2347 ) of the submandibular gland with possible involvement of IgG4-RD. PRESENTATION OF CASE: The @entity1 was a 59-year-old @entity1 presenting with a swollen right submandibular gland. Laboratory tests revealed IgG4 levels of 176mg/dl (reference range: 4.8-105). An initial open biopsy for histological diagnosis showed @entity7841 . The region was monitored on an outpatient basis, and finally the right submandibular was totally resected because @entity5 could not be excluded. Histological examination of the submandibular gland showed an @entity2347 with lymphocytic infiltration containing many IgG4-positive plasma cells in the @entity5 stroma. DISCUSSION: We have described a case that indicated a possible involvement of @entity2347 with IgG4-RD. This allows us to speculate that longstanding IgG4-RD may progress to @entity5 or infiltration of IgG4-positive plasma cells through the signals of @entity5 stimuli. Further investigations are required to determine the potential pathogenic mechanism underlying this unique @entity5 . CONCLUSION: This case underscores that caution is needed in the diagnosis of masses with high serum IgG4 levels, as the differential diagnosis includes @entity5 .
