Systematic Review and Meta-Analysis of XXXX Analogues in the Prevention of Postoperative Complication after Pancreaticoduodenectomy.

@entity1 @entity548 @entity22798 @entity3472 @entity2390 @entity1943
BACKGROUND: The use of @entity1943 analogues (SAs) following pancreaticoduodenectomy (PD) is controversial. METHOD: Literature databases were searched systematically for relevant articles. A meta-analysis of all randomized controlled trials (RCTs) evaluating prophylactic SAs in PD was performed. RESULTS: Fifteen RCTs involving 1,352 @entity1 were included. There was a towards reduced incidences of @entity3472 (p = 0.26), clinically significant @entity3472 (p = 0.08), and @entity548 (p = 0.05) in prophylactic SAs group. In subgroup analyses, prophylactic @entity1943 significantly reduced the incidence of @entity3472 (p = 0.02), with a nonsignificant trend toward reduced incidence of clinically significantly @entity3472 (p = 0.06). @entity22798 significantly reduced the incidence of clinically significantly @entity3472 (p = 0.03). @entity2390 had no influence on the incidence of @entity3472 . CONCLUSION: The current best evidence suggests prophylactic treatment with @entity1943 or @entity22798 has a potential role in reducing the incidence of @entity3472 , while @entity2390 had no influence on the incidence of @entity3472 . High-quality RCTs assessing the role of @entity1943 and @entity22798 are required for further verification.    2015 S. Karger AG, Basel.
