Acute XXXX : a long-term follow-up study.

@entity1 @entity227 @entity308 @entity697 @entity2621 @entity602 @entity1939 @entity792 @entity14930
PURPOSE: To report the long-term follow-up of @entity1 with acute @entity14930 (AZOOR). DESIGN: Observational consecutive case series. METHODS: Prospective and retrospective review of medical records of @entity1 with AZOOR. RESULTS: Fifty-one @entity1 (37 @entity1 and 14 @entity1 ) with a median age of 33 years (mean, age 36 years; range, 13-63 years) were followed for a median of 96 months (mean 100 months; range, 36-420 months). At presentation, AZOOR was present in one eye of 31 @entity1 (61%) and both eyes in 20 @entity1 (39%). All @entity1 presented with an acute loss of one or more zones of visual field, and 45 (88%) @entity1 presented with photopsia. Corrected visual acuity was 20/40 or better in 68 (76%) of 90 affected eyes. Funduscopic examination was normal in 82 eyes and revealed signs of AZOOR in 8 eyes. Electroretinographic amplitudes were @entity308 in all affected eyes. The median delay in diagnosis of AZOOR was 17 months. During follow-up, AZOOR developed in 19 fellow eyes. At final follow-up AZOOR was present in one eye of 12 (24%) @entity1 and both eyes of 39 (76%) @entity1 . Sixteen @entity1 had 23 recurrences of AZOOR. Visual field loss stabilized within 6 months in 37 @entity1 (72%), progressed stepwise in 2 @entity1 (4%), and partly improved in 12 @entity1 (24%). Fourteen @entity1 (28%) had @entity792 , including @entity2621 in 6 @entity1 and relapsing transverse @entity602 in 4 @entity1 . At last follow-up all @entity1 had residual @entity227 . Final visual acuity was 20/40 or better in 61 (68%) affected eyes. Nine @entity1 (18%) were @entity1939 . The fundi of 90 affected eyes revealed no changes of AZOOR in 47 eyes (52%) and changes in the pigment epithelium and retina caused by AZOOR in 43 eyes (48%). CONCLUSIONS: @entity227 in AZOOR is characterized by one or more episodes of @entity697 , and in some cases, death of retinal receptor cells in one or more zones of one or both eyes. Central vision is often spared, but recovery of visual field occurs infrequently. The etiology of AZOOR is unknown. Electroretinography is essential for early diagnosis. The value of treatment is uncertain.
