XXXX of the lower lip. Review of the literature and report of five cases.

@entity1 @entity10212 @entity27866 @entity9335 @entity2024 @entity18550
@entity27866 ( @entity27866 ) is a chronic, familial, @entity9335 that primarily affects American Indians. It is more prevalent in young females and may be evident clinically as a pruritic lower lip @entity10212 that typically does not respond to conventional therapy. Other clinical features associated with @entity27866 include @entity2024 , alopecia of the eyebrows, and formation of @entity18550 . The histologic features of @entity27866 have been described as nonspecific. We are presenting five cases of @entity27866 in which the major clinical manifestation was a pruritic, unsightly lower lip @entity10212 . All of our @entity1 were American Indians. Three @entity1 were from the same family. The youngest @entity1 was 10 years old and the oldest was 69 years old. All five cases were characterized histologically by numerous germinal centers within the lamina propria and a dense perivascular plasma cell infiltrate. In four of the five cases, there was a moderate to dense infiltrate of eosinophils. All five @entity1 had been generally unresponsive to conventional therapy. With the exception of the youngest @entity1 , all had had the disease for at least several years. One @entity1 , now deceased, had the lower lip lesion surgically removed for cosmetic reasons. To our knowledge, this is the first report in the dental literature that describes the clinical and histologic features of @entity27866 of lower lip.
