Change of walking distance in XXXX : impact on inflammation, oxidative stress and mononuclear cells: a pilot study.

@entity1 @entity15054 @entity2002 @entity42036 @entity2937 @entity5750 @entity26 @entity2936 @entity6931 @entity2935 @entity4621 @entity613 @entity4071 @entity9536 @entity731
BACKGROUND: @entity731 is a chronic inflammatory process involving the immune system and formation of reactive @entity26 species (ROS). We investigated changes of mononuclear blood cells and ROS production in relation to the walking distance of @entity1 with @entity613 during home-based exercise training. METHODS: Forty @entity1 with @entity613 were asked to perform a home-based exercise training for a mean time of 12  months. ROS formation was measured using the @entity6931 analogue @entity42036 . Peripheral blood leucocytes [monocytes, polymorphonuclear neutrophils (PMN) and dendritic cells (DC)] were analysed by flow cytometry and analysed for the expression of major inflammatory surface molecules. RESULTS: At follow-up, @entity1 showed an increased walking distance and reduced ROS production upon stimulation with a @entity4621 derivative (PDBu) (p  <  0.01). Monocytes changed their inflammatory phenotype towards an increased anti-inflammatory @entity5750 (++) @entity4071 (-) subpopulation (p  <  0.0001). Adhesion molecules @entity9536 , @entity2935 and @entity15054 on monocytes and PMN decreased (all p  <  0.01). On DC expression of HLA-DR, @entity2937 or @entity2936 decreased at follow-up. Inflammatory markers like @entity2002 , C-reactive protein or soluble @entity15054 (sTREM-1) decreased over the observation period. Finally, we found a close relation of sTREM-1 with the walking distance, @entity2002 and ROS production. CONCLUSIONS: We observed an amelioration of the proinflammatory phenotype on monocytes, DC and PMN, as well as a reduced ROS production in PAD @entity1 under home-based exercise, paralleled by an increased walking distance. Our data suggest that a reduced inflammatory state might be achieved by regular walking exercise, possibly in a dimension proportionately to changes in walking distance.
