Early and late B cell immune responses in lethal and self-cured rodent XXXX .

@entity19 @entity281 @entity5895 @entity501 @entity311
ICR @entity19 have heterogeneous susceptibility to lethal @entity501 yoelii 17XL from the first days of experimental @entity281 as evidenced by the different @entity5895 levels and clinical outcomes. This @entity19 model has revealed specific immune responses on peripheral blood correlating with the @entity281 fate of the animals. To search for immune-markers linked to @entity5895 we examined B lymphocytes in organs of the immune system as key effectors of rodent immunity against @entity311 . To determine changes in immune cellularity fostered by the different @entity5895 we examined B cell subsets in low (<15%) and high (>50%) parasitized @entity19 during the first days of the @entity281 . In the case of surviving @entity19 , we studied the preservation of memory immune response 500 days after the primary @entity501 challenge. Correlating with the @entity5895 level, it was observed an increase in total cellularity of spleen during the first week of @entity281 which remained after 16 months of the @entity281 in surviving animals. B cell subsets were also modified across the different @entity281 fates. Subpopulation as follicular B cells and B-1 cells proportions behaved differently depending on the @entity5895 kinetics. In addition, peritoneal cavity cells proliferated in response to high @entity5895 . More significantly, @entity501 -specific memory B cells remained in the spleen 500 days after the primo- @entity281 . This study demonstrates that B cell kinetics is influenced by the different @entity5895 courses which are naturally developed within a same strain of untreated @entity19 . We show that high levels of @entity5895 at the beginning of @entity281 promote an extremely fast and exacerbate response of several cell populations in spleen and peritoneal cavity that, in addition, do not follow the kinetics observed in peripheral blood. Furthermore, our results describe the longest persistence of memory B cells long time upon a single @entity281 in @entity19 .
