'Pseudomesotheliomatous' XXXX of the pleura: a 10-year analysis of cases from the Environmental Lung Disease Research Group, Cardiff.

@entity1 @entity788 @entity263 @entity8174 @entity5 @entity957 @entity2 @entity189 @entity3909 @entity2615 @entity3620 @entity1358 @entity1606 @entity11534 @entity4205 @entity9820 @entity420
AIMS: To undertake a clinicopathological study of @entity11534 of epithelial histogenesis which clinically and pathologically mimic @entity3620 . METHODS AND RESULTS: Over a 10-year (1990-2000) study period 53 @entity189 mimicking @entity2615 ('pseudomesotheliomatous' @entity189 ) were identified. The study group comprised 50 @entity1 and three females, age range 33-77 (median 68) years. In 46 (87%) cases there was a history of smoking and in 40 (76%) cases a history of asbestos exposure. Histologically the @entity189 could be divided into two broad groups: primary @entity2 with florid pleurotropic growth (n = 47), of which 34 (70%) were @entity420 ; and diffuse @entity3909 involvement of the pleura by @entity5 (n = 6). This latter group comprised two @entity1606 of @entity1358 , one ductal @entity788 , one @entity263 and one @entity957 of @entity8174 gland origin. Follow-up data were available in 35 cases. @entity5 type, survival was poor (median 8 months) and comparable to @entity2615 . CONCLUSIONS: @entity189 are uncommon (comprising 6% of referrals), pathologically heterogeneous @entity5 with poor prognosis. Tissue diagnosis should be obtained in all cases of suspected @entity5 . By light microscopy and immunophenotype many of the @entity5 mimicked @entity3620 . In particular, an awareness that all @entity5 exhibiting squamous differentiation may express @entity4205 and @entity9820 is important to prevent misinterpretation. In this respect, calretinin is regarded as the most specific and sensitive mesothelial marker. Misdiagnosis may have medico-legal implications in asbestos-related compensation claims.
