[Experience with gamma globulins per os in the therapy and prevention of XXXX ].

@entity1 @entity3082 @entity294 @entity7491 @entity7414 @entity6425
The efficacy of oral gammaglobulin in the treatment of acute @entity294 in immunocompetent @entity1 has been evaluated in an open placebo controlled trial. Moreover the efficacy of oral gammaglobulin has been tested also for treatment of chronic @entity294 in @entity7491 @entity1 and for prevention of @entity6425 during an @entity3082 in the ward. 54 @entity1 (aged 1-36 months) with acute @entity294 (30 rotavirus +) were enrolled in the study. 24 out of 54 were assigned with randomised method to group a receiving gammaglobulin 150 mg/kg x 2 in the first day of admission to hospital and the remaining 30 @entity1 were assigned to group b receiving placebo. @entity294 cleared up in 2.57 +/- 1.4 days without a significant difference between group a and b (2.6 +/- 1.6 and 2.46 +/- 1.1 days respectively). The @entity294 's duration in Rotavirus+ @entity1 was 2.78 +/- 1.4 days in group a and 3 +/- 1.4 days in group b again without a significant difference. The excretion time of rotavirus in the stools was significantly shorter in @entity7414 (2.6 +/- 1.3) than in rotavirus group b (3.9 +/- 1.6) with p < 0.04. Three @entity1 (4.9 months) with chronic post- @entity294 and @entity7491 (< 5 mg%ml) received gammaglobulin 300 mg/kg/die for 3 days. The @entity294 recovered in 2-3 days. Out of 16 @entity1 hospitalized during an @entity3082 rotavirus @entity294 6 @entity1 received oral gammaglobulin at the dose of 150 mg/kg/die during the hospitalization period (that was at least 5 days). No one became ill.(ABSTRACT TRUNCATED AT 250 WORDS)
