Effects of XXXX inhibition versus conventional antihypertensive therapy on the glomerular filtration rate.

@entity1 @entity8 @entity1289 @entity101 @entity6 @entity2316 @entity21261 @entity15157 @entity2165 @entity1098
Antihypertensive treatment has been shown to slow down the decline in glomerular filtration rate (GFR) with time. This has been most extensively studied in @entity1 with @entity2316 and, to some extent, with other forms of @entity8 . @entity1289 ( @entity1289 ) inhibition has been shown to be more effective in this regard than conventional antihypertensive therapy. This important aspect of antihypertensive treatment has not been studied previously in @entity1 with essential @entity101 . Preliminary results regarding the effects of two different antihypertensive therapies on the loss of GFR with time, determined with 51Cr- @entity1098 clearance after 6, 12, and 24 months of treatment, are presented here. The GFR was assessed in a prospective, randomized, double-blind trial in 257 @entity1 with essential @entity101 . All had a normal renal function, and none had @entity6 or @entity15157 . The two therapeutic modalities were the @entity1289 inhibitor @entity21261 and the beta-adrenoceptor blocking agent @entity2165 . Both therapies were equally effective in lowering the systolic blood pressure. However, @entity2165 was slightly but significantly more effective in lowering the diastolic blood pressure after 6, 12, and 24 months. The decline in GFR with time was significantly smaller with @entity21261 than with @entity2165 . After 6 months, the reduction in GFR was 1.0 ( @entity21261 ) vs. 4.0 ( @entity2165 ) ml/min x 1.73 m2 (p < 0.01). After 12 months the corresponding changes were 2.0 vs. 4.5 ml/min x 1.73 m2 (p < 0.05) and after 24 months 3.0 vs. 4.0 ml/min x 1.73 m2 (n.s.).(ABSTRACT TRUNCATED AT 250 WORDS)
