@entity1860 in The Netherlands: a Population-Based Study on Incidence, Treatment and Survival in 3,585 XXXX from 1989-2012.

@entity1 @entity204 @entity1860 @entity1349
OBJECTIVE: To assess the impact and results of treatment of @entity1860 in the general population, we conducted a population-based, nation-wide study on 3,585 @entity1860 @entity1 diagnosed between 1989 and 2012 in the Netherlands. METHODS: @entity1 demographics were obtained from the Netherlands Cancer Registry. Information on age, gender, year of diagnosis, first treatment and date of @entity204 were recorded. @entity1349 ( @entity1349 ) was adjusted for @entity204 rates in the normal population. RESULTS: Incidence in males decreased slightly from 1.2 per 100.000 @entity1 years (PY) in 1989-2000 to 0.9 in 2001-2012. For females, incidence remained stable with 0.7 per 100.000 PY in both periods. Incidence was age dependent and highest in males in the last decades of life. Treatment before 2000 mainly consisted of chemotherapy, while after 2007 TKI use was 88%. Five-year relative survival was only 36% before the introduction of TKIs but significantly increased to79% after the introduction of TKI. CONCLUSIONS: This study gives insight in @entity1860 incidence, treatment and survival in routine care in the Netherlands. Although @entity1349 improved since the introduction of TKIs, there is still room for further improvement. This article is protected by copyright. All rights reserved.
