Relation of @entity880 production to postischaemic reduction in function and myocardial @entity26 consumption after partial coronary occlusion in XXXX .

@entity1707 @entity296 @entity308 @entity26 @entity1563 @entity450 @entity880
Postischaemic @entity296 (stunning) induced by partial occlusion of the left anterior descending coronary artery and its relation to @entity880 production during reperfusion were studied in nine @entity1707 . A 40% reduction in regional left ventricular wall thickening, as measured by ultrasonic crystals, was prospectively defined as stunning. A perfusion pressure of 20 mmHg was maintained with a hydraulic occluder for each ischaemic period and was monitored by a distal arterial catheter. To achieve a 40% reduction in function, four animals required three ischaemic periods (mean ischaemic @entity450 73%), four two (86% @entity450 ), and one one (93% @entity450 ). At 25 min of reperfusion transmural flow was slightly reduced from 0.67 ml.g-1.min-1 at control to 0.58 ml.g-1.min-1 (p less than 0.05), whereas regional flow endocardial to epicardial flow ratio was unchanged. At 60 min reperfusion, percentage systolic wall thickening was reduced to 25% from a control of 39% (p less than 0.01) and parallel reductions in regional myocardial @entity26 consumption from 4.3 ml.min-1 to 2.7 ml.min-1 occurred (p less than 0.01). @entity880 extraction was @entity308 at 15 min reperfusion (-4.0% compared with control +18.0% (p less than 0.05)) but returned to control values by 30 min. It is concluded that postischaemic @entity296 (stunning) can be induced by partial @entity1563 and that the extent of dysfunction depends on the degree of @entity450 . The reductions in myocardial @entity26 consumption parallel those of wall thickening during reperfusion after stunning. Finally, @entity880 production occurs during early reperfusion but does not persist with the postischaemic reductions in function and myocardial @entity26 consumption.
