Technical considerations related to the minute ventilation/ @entity544 output slope in patients with XXXX .

@entity712 @entity1576 @entity544
BACKGROUND: The minute ventilation (VE)- @entity544 output (VCO(2)) relationship has recently been demonstrated to have prognostic significance in the @entity712 ( @entity712 ) population. However, the method by which the VE/VCO(2) slope is expressed has been inconsistent. METHODS: One hundred eighty-eight subjects, who had received diagnoses of @entity712 , underwent exercise testing. Two VE/VCO(2) slope calculations were made, one using exercise data prior to the @entity1576 ( @entity1576 ), and one using all data points from rest to peak exercise. Four separate peak exercise VE/VCO(2) slope calculations also were derived with unaveraged, 10-s, 30-s, and 60-s ventilatory expired gas sampling intervals. RESULTS: Although univariate Cox regression analysis demonstrated pre- @entity1576 and peak VE/VCO(2) slope calculations to both be significant predictors of cardiac-related mortality and hospitalization (p < 0.001), the peak classification scheme was significantly better (p < 0.01). The ventilatory expired gas-sampling interval that was used did not impact the predictive ability of the peak VE/VCO(2) slope. CONCLUSION: Although both the pre- @entity1576 and peak VE/VCO(2) slope calculations were prognostically significant, the peak expression was superior. The sampling interval did not appear to have a significant impact on prognostic utility. We hope that the results of the present study will contribute to the standardization of the VE/VCO(2) slope and will enhance its clinical application.
