[The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of XXXX in @entity19 ].

@entity1 @entity410 @entity3175 @entity2050 @entity19 @entity14967 @entity1092 @entity2052 @entity109 @entity3174 @entity6191 @entity32666 @entity8821 @entity17979 @entity2049 @entity2053
The relationship between concentrations of anticonvulsive drugs in the brain and various parameters of @entity410 was investigated in @entity19 . Maximal electroshock seizures were elicited with a current intensity (60 Hz, 50 mA for 0.2 sec) through corneal electrodes. @entity410 movements were detected by an accelerometer, amplified and recorded by a polygraph. Concentrations of anticonvulsive drugs in the whole brain were determined by the method of enzyme immunoassay. With various doses of @entity109 (PB: 5-35 mg/kg, i.p.), duration of @entity6191 ( @entity6191 ) was prolonged, whereas duration of @entity6191 ( @entity6191 ) and clonic @entity410 ( @entity410 ) was shortened in a dose-dependent manner. The correlation coefficient between the PB concentration and the duration of @entity6191 , @entity6191 or @entity410 was 0.680, -0.882 or 0.409, respectively. The correlation coefficient between the PB concentration and the intensity of @entity6191 or @entity410 , measured by the integrated curve of the accelerometer, was -0.847 or 0.440. The correlation coefficient between the PB concentration and the ratio of @entity6191 -duration/ @entity6191 -duration ( @entity6191 / @entity6191 ratio) was -0.901. After administration of @entity3174 (PNT), @entity2049 ( @entity2050 ) or @entity1092 ( @entity2052 ), a highly negative correlation between the drug level in the brain and the @entity6191 / @entity6191 ratio was also obtained. In the case of @entity3175 , @entity2053 , @entity17979 or @entity14967 , the @entity6191 / @entity6191 ratio was decreased dose-dependently, but the slope of the dose-response regression line was less steep than that obtained by the administration of PB, @entity32666 , @entity2050 , @entity2052 or @entity8821 . These results suggest that the @entity6191 / @entity6191 ratio may be the most reliable parameter for drug evaluation of the anticonvulsive efficacy against @entity410 in @entity1 @entity1 .
