[Effect of atherogenic diet on the liver lipid level and development of aortic sclerosis in XXXX ].

@entity407 @entity3937 @entity235 @entity1674 @entity6742 @entity731 @entity1718 @entity8557 @entity165
Metabolic efficiency of the liver of 16 @entity235 , mixed breed, sexually mature, of both sexes was studied in a lasting experiment. The animals were kept in cages without a run, divided into 3 groups - k, A6 and A12. They were fed an atherogenic diet for 6 and 12 months. Beside @entity165 pork fat and @entity6742 , the diet contained @entity3937 . Hepatic lipids were analysed by the method of thin-layer chromatography and densitometric measurements. The numerical results statistically verified have been given in mg/g of wet liver tissue taken from the right lobe, homogenized and extracted after the method of Folch et al. Pathomorphological changes in the abdominal aorta were evaluated macro- and microscopically. The magnitude of aortosclerotic changes was compared with mean values of hepatic lipids. The numerical values and the image of chromatographic distribution are shown in Table 1 and Figs 1, 2 and 3. After 6 month feeding, in group A6 the authors observed a considerable increase of hepatic lipids, preserved capability of @entity165 esterification and the occurrence of early atherosclerotic changes in the aorta. After 12 months, the level of lipids such as phospholipids, free @entity1718 , @entity1674 and free @entity165 increased. However, a turning point in the capability of @entity165 esterification was observed, which was expressed by a decrease of @entity8557 . In the abdominal aorta developed @entity731 marked with 2 and 3 pluses was found. It is concluded that beside @entity3937 and overloading highcaloric diet, lack of movement contributed to metabolic disturbances expressed by hepatopathy, @entity407 and aortosclerosis, which has a great influence in @entity235 on preservation of homeostasis of the organism.
