Determinants and estimation of healing times in XXXX .

@entity1 @entity1095 @entity6 @entity1066 @entity1109 @entity1411 @entity413 @entity4760
AIMS: To assess the wound size reduction and time course for healing and to establish equations to predict the time course of wound healing in @entity1109 , and ischemic @entity4760 . METHODS: This prospective study evaluates wound healing over at least a 10-week period in 31 Type 1 or Type 2 @entity6 @entity1 with @entity1411 . Thirteen consecutive @entity6 @entity1 with @entity1411 , 10 consecutive @entity6 @entity1 with neuroischemic ulceration, and 8 @entity6 @entity1 with @entity1095 were selected for the study. All @entity1 received identical @entity1066 wound care including use of proper footwear, non-weight-bearing limb support, use of appropriate antibiotics, debridement, tight control of serum @entity413 levels, and careful monitoring of the @entity1066 . @entity1066 was assessed by planimetric measurement of the wound area every second week until wound healing. The time course of wound healing was calculated by the daily wound radius reduction. RESULTS: The wound area (mean+/-S.E.) in the @entity1 with @entity1411 was 61.2+/-17.1 at the beginning and 3.2+/-1.5 mm(2) after 70 days (P=.005). The wound radius decreased by 0.045 mm (95% confidence interval [CI] 0.039-0.055) per day, with most of the wound healing being achieved between the first and seventh week of @entity1066 care. The average healing time was 77.7 (95% CI 62-93) days. In the neuroischemic group, the initial average wound area was 26.6+/-7.0 mm(2), and 6.25+/-1.7 mm(2) after 10 weeks (P=.007). The wound radius reduction was 0.019 mm/day (95% CI 0.017-0.023) with an average healing time of 123.4 (95% CI 101-145) days. The @entity6 @entity1 with @entity1095 had an average wound size of 32.6+/-13.1 at the beginning and 23.9+/-10.7 mm(2) after 70 days of @entity1066 care (P=.06). The daily wound radius reduction was 0.0065 mm (95% CI 0.0039-0.0091). Average @entity1066 duration was 133 (95% CI 116-149) days, but three of eight @entity1 achieved no wound healing. CONCLUSIONS: Providing standard care, the time course of wound healing in @entity4760 is predominantly determined by etiologic factors, and less by wound size. Taking wound etiology and wound radius into account, the expected healing time can reliably be estimated in @entity1066 .
