Alterations in XXXX metabolism in cirrhotic @entity1 before and after liver transplant.

@entity1 @entity82 @entity6 @entity2690 @entity1735 @entity413
AIM: The main objective of this study is to demonstrate whether @entity1735 metabolism alterations identified in @entity1 with advanced @entity82 show any improvement after liver transplant. METHODS: The study included 86 @entity1 who underwent liver transplant between March 2010 and February 2011. An oral @entity413 tolerance test was performed before the liver transplant, and 6 and 12 months after. Beta cell function and @entity2690 resistance were also calculated, applying formulae that use basal plasma glycaemia and @entity2690 , and plasma glycaemia and @entity2690 during an oral @entity413 tolerance test. Risk factors for pre- and post-transplant @entity6 were also studied. The diagnosis of @entity6 was based on an OGTT. RESULTS: The proportion of @entity1 with @entity6 before transplant, and at month 6 and 12 after transplant were 70.9%, 48.8% and 39.2%, respectively. Compared to baseline, at month 6 the odds ratio of having @entity6 was 0.39 (IC 95% [0.21, 0.73]) and at month 12 it was 0.26 (IC 95% [0.14, 0.50]). The composite @entity2690 sensitivity index values at 6 and 12 months were 1.72 units higher (IC 95% [0.84, 2.58]) and 1.58 units higher (IC 95% [0.68, 2.44)] than baseline. A statistically significant association was found between high MELD values and high body mass index, and risk of pre-transplant @entity6 (p=0.001 and p=0.033, respectively). @entity82 aetiology did not influence the risk of @entity6 . CONCLUSIONS: In this study, we were able to ascertain that alterations in @entity1735 metabolism typical of advanced @entity82 improve after liver transplant. This improvement is mainly due to an improvement in @entity2690 resistance.
