Interest in genetic testing for modest changes in XXXX risk: implications for SNP testing.

@entity1 @entity5 @entity0 @entity5344
BACKGROUND: Advances in genomics may eventually lead to 'personalized genetic medicine,' yet the clinical utility of predictive testing for modest changes in risk is unclear. We explored interest in genetic testing for genes related to modest changes in @entity0 risk in @entity1 at moderate to high risk for @entity0 . METHODS: @entity1 (n = 105) with a negative breast biopsy and >= 1 relative with @entity5344 completed telephone surveys. We measured demographic and psychosocial variables and, following presentation of hypothetical scenarios of genetic tests for lower-penetrance @entity0 gene mutations, assessed interest in willingness to pay for and comprehension of test results. We used logistic regression models with generalized estimating equations to evaluate combinations of risk level, cost and behavioral modifiers. RESULTS: Many @entity1 (77%) reported 'definite' interest in genetic testing, with greater interest in tests that conveyed more risk and cost less. Behavioral modifiers of risk (taking a vitamin; diet/exercise), having a regular physician, greater perceived benefits of genetic testing, and greater @entity5 worry also influenced interest. Most @entity1 (63%) did not understand relative vs. absolute risk. @entity1 with less understanding reported more @entity5 worry and greater willingness to pay for testing. CONCLUSION: Interest in genetic testing for mutations related to modest changes in risk was high, modified by both test and psychosocial factors. Findings highlight the need for education about benefits and risks of testing for mutations that convey modest changes in risk, particularly given the current lack of clinical validity/utility and availability of direct-to-consumer genetic testing.
