Critical involvement of @entity630 -related cytokines in XXXX induced by ischemia and reperfusion.

@entity8 @entity10183 @entity5721 @entity19 @entity73 @entity60 @entity777 @entity1011 @entity630
@entity8 and @entity5721 (IRI) is considered an inflammatory syndrome. To move forward in its pathogenesis, we exploited the role of several cytokines on @entity8 triggered by IRI. Specifically to evaluate the role of @entity630 immune profile in this system, IL-12, @entity60 , and @entity60 /IL-12 deficient (KO) @entity19 on C57BL/6 background and their controls were subjected to IRI. In each group, blood and kidney samples were harvested. Renal function was evaluated by serum @entity1011 and renal morphometric analyses. Gene expression of @entity777 and @entity10183 were also investigated by Q-PCR. @entity60 KO animals presented the @entity73 in renal function compared to controls. Conversely, IL-12 KO animals were absolutely protected and, in a lesser extent, @entity60 /IL-12 KO double knockout was also protected from IRI. Gene expression analyses showed higher expression of @entity10183 , a cytoprotective gene, and @entity777 , a pro-inflammatory cytokine, in @entity60 deficient animals subjected to IRI. Our results confirm that @entity630 related cytokines such as IL-12 and @entity60 are critically involved in @entity8 and @entity5721 .
