Changes in Bone Mineral Density in the Year after XXXX .

@entity1 @entity174 @entity3124 @entity170 @entity604 @entity79 @entity173
RATIONALE: @entity3124 may be associated with @entity79 and loss of @entity79 ( @entity79 ). Prospective evidence describing long-term changes in @entity79 after @entity3124 is needed to further define this relationship. OBJECTIVES: To measure the change in @entity79 and bone turnover markers (BTMs) in subjects 1 year after @entity3124 compared with population-based control subjects. METHODS: We studied adult @entity1 admitted to a tertiary intensive care unit (ICU) who required mechanical ventilation for at least 24 hours. We measured clinical characteristics, BTMs, and @entity79 during admission and 1 year after ICU discharge. We compared change in @entity79 to age- and sex-matched control subjects from the Geelong @entity170 Study. MEASUREMENTS AND MAIN RESULTS: Sixty-six @entity1 completed @entity79 testing. @entity79 decreased significantly in the year after @entity3124 at both femoral neck and anterior-posterior spine sites. The annual decrease was significantly greater in the ICU cohort compared with matched control subjects (anterior-posterior spine, -1.59%; 95% confidence interval, -2.18 to -1.01; P   <   0.001; femoral neck, -1.20%; 95% confidence interval, -1.69 to -0.70; P   <   0.001). There was a significant increase in 10-year fracture risk for major @entity174 (4.85        5.25 vs. 5.50        5.52; P   <   0.001) and @entity173 (1.57        2.40 vs. 1.79        2.69; P   =   0.001). The pattern of bone resorption markers was consistent with accelerated bone turnover. CONCLUSIONS: @entity3124 individuals experience a significantly greater decrease in @entity79 in the year after admission compared with population-based control subjects. Their bone turnover biomarker pattern is consistent with an increased rate of @entity604 .
