XXXX prominent intracytoplasmic lumina.

@entity8880 @entity8 @entity1637 @entity39 @entity5 @entity703
@entity1637 is a histologically distinctive @entity703 , with a well-recognized cytoarchitectural appearance. On occasion, however, @entity8880 are known to exhibit unusual morphologic features that may pose diagnostic difficulties. We present the clinical and pathologic details of an @entity8 with an unusual histologic appearance imparted by the presence of large numbers of prominent intracytoplasmic lumens. Morphologically, the @entity5 was composed of uniform polygonal cells with copious amounts of granular, eosinophilic cytoplasm, round nuclei, and prominent nucleoli, exhibiting an organoid pattern of growth. Intracytoplasmic lumina of varying size were present throughout the @entity5 . There were no mitotic figures or areas of @entity39 present. The diagnosis of @entity1637 was supported by immunohistochemical and ultrastructural studies. By electron microscopy, the intracytoplasmic lumens appeared as membrane bound spaces with associated microvilli. The presence of intracytoplasmic lumina in a significant proportion of cells is an uncommon feature of @entity8880 which can generate problems in diagnosis. Awareness of this phenomenon should allow for improved recognition of @entity1637 exhibiting this type of unusual morphology.
