[Changes in Cerebral Blood Flow and Cognitive Function in XXXX Undergoing Coronary Bypass Surgery With Cardiopulmonary Bypass].

@entity1 @entity227 @entity73 @entity741 @entity1167
PURPOSE: to study effect of coronary artery bypass graft (CABG) surgery with @entity1167 ( @entity1167 ) on regional cerebral blood flow and cognitive function in @entity1 with @entity741 ( @entity741 ). MATERIAL AND METHODS: We included into this study 22 @entity1 with @entity741 subjected to CABG surgery with @entity1167 . All @entity1 underwent brain SPECT scanning and comprehensive neuropsychological testing 1 day before, 10-14 days and 6 months after surgery. RESULTS: Overall CABG with @entity1167 was followed by reduction of regional cerebral blood flow relative to baseline in frontal and parietal cortex (p < 0.01). Substantial reduction (> 5%) of cerebral perfusion in early postoperative period was observed in 15 @entity1 (68%) while seven @entity1 (32%) had no significant changes of regional cerebral blood flow. Changes of cerebral perfusion correlated with dynamics of cognitive status. Mean measures of immediate verbal memory, delayed memory, and learning decreased after surgery by 25.6 (p = 0.002), 43.3 (p = 0.000003), and 23.1% (p = 0.00000), respectively. Moreover after CABG with @entity1167 @entity1 demonstrated slowing of psychomotor speed by 13.6% (p = 0.03). CONCLUSION: CABG with @entity1167 was associated with reduction of cerebral perfusion leading to @entity73 . Immediate and delayed @entity227 , learning and psychomotor speed were most sensitive to the negative effects of surgery.
