@entity3920 inhibitor improves survival in hamsters with XXXX .

@entity1 @entity3920 @entity2178 @entity1283 @entity1188 @entity329 @entity916 @entity583 @entity72480
The purpose of the present study was to assess the effects of chronic treatment with an orally active @entity3920 inhibitor, @entity72480 ( @entity72480 ), in a hamster @entity583 model. In the first experiment, after confirming the biochemical inhibitory action of @entity72480 on @entity1 and hamster chymases (Ki = 6.2 and 30.6 nM, respectively), the biological action of @entity72480 in vivo was assessed by the inhibition of hamster @entity3920 -induced microvascular leakage. In the second experiment, @entity583 was produced by coronary artery ligation in male @entity329 . @entity72480 (0.1% containing chow) was given 24 h after surgery and continued for 3 or 5 weeks, while the control and sham-operated groups were fed a standard chow. The survival rate was assessed in each group. At the end of each study period, blood pressure was measured at the left hind-limb, the heart rate and cardiac function were measured by echocardiography, the end-diastolic pressure by a direct catheterization, and organ weights and biochemical parameters, including plasma @entity916 and angiotensin-converting enzyme activities and plasma @entity2178 and @entity2178 concentrations, were measured. In the first experiment, a standard chow containing 0.1% @entity72480 completely inhibited the hamster @entity3920 -induced microvascular leakage. In the second experiment, @entity72480 treatment significantly increased the survival rate (37% versus control), and attenuated @entity1283 (13% versus control) and end-diastolic left ventricular pressure (34% versus control), but it did not decrease the @entity1188 size nor improve the ejection fraction. The plasma @entity2178 concentration post- @entity583 was significantly suppressed by @entity72480 throughout the study period. We conclude that @entity72480 is an orally active useful @entity3920 inhibitor and improves survival and @entity1283 of the post- @entity583 hamster.
