Inhalation exposure to @entity1324 induces selective damage on olfactory neuroepithelium in XXXX .

@entity19 @entity1324 @entity22261 @entity4698
Due to their specific position in the nasal cavity, the cells of olfactory neuroepithelium can be damaged by exposure to environmental airborne chemicals. However, few studies have been focused on selective damage, i.e. olfactory sensory neurons, basal cells, supporting and duct cells. As solvents are known to induce critical effects on olfactory neuroepithelium (OE), this study was designed to characterize histological and immunohistological effects induced by @entity1324 exposure on OE in @entity19 . Behavioral tests were conducted to evaluate olfactory sensitivity. Moreover, olfactory neuroepithelium was examined to evaluate the thickness and the total number of cells. Finally, different markers, @entity22261 ( @entity22261 ) and @entity4698 ( @entity4698 ), were used to characterize respectively olfactory sensory neurons and basal cells, and secondly to evaluate the dynamic of the tissue turnover. Results showed structural modifications, since the thickness and the number of cells in the OE were modified according to the time course of the exposure. Additionally, no changes for @entity22261 -positive cells were observed whereas significant differences appeared for the density of @entity4698 -positive cells in relation to their location (main-body or basal layer of OE). These findings indicate that @entity1324 exposure induces selective damage in olfactory neuroepithelium.
