MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in XXXX .

@entity308 @entity20214 @entity19 @entity1316 @entity969 @entity148 @entity777 @entity4207 @entity637
UNASSIGNED: @entity308 have complex and multi-faceted underlying mechanisms, rendering these disorders difficult to treat consistently and effectively. One under-explored therapeutic strategy for alleviating @entity1316 is the targeting of microRNAs (miRs). miRs are small non-coding RNAs that cause sequestration/degradation of specific mRNAs, thereby preventing protein translation and downstream functions. @entity20214 has validated and predicted neurotrophic factor and inflammatory mRNA targets, which led to our hypothesis that @entity20214 deletion would modulate affective behaviors. To evaluate @entity148 -like behavior, wildtype (wt) and @entity20214 knockout (ko) @entity19 (littermates; both male and female) were assessed in the open field and on an elevated plus maze. In both tests, @entity20214 ko @entity19 spent more time in open areas, suggesting they had reduced @entity148 -like behavior. @entity308 -like behaviors were assessed using the forced swim test. Compared to wt @entity19 , @entity20214 ko @entity19 exhibited reduced float duration and increased latency to float. Further, although all @entity19 exhibited a strong preference for a @entity969 solution over water, this preference was enhanced in @entity20214 ko @entity19 . @entity20214 ko @entity19 had no @entity4207 (Barnes maze) or social preference/novelty suggesting that changes in mood were specific. Finally, compared to wt hippocampi, @entity20214 ko hippocampi had a reduced inflammatory signature (e.g., decreased @entity777 , @entity637 ) and female @entity20214 ko @entity19 increased ciliary neurotrophic factor expression. Together, these data highlight the importance of studying microRNAs in the context of @entity148 and @entity308 and identify @entity20214 as a novel potential therapeutic target for improving @entity1316 .
