Predictive value of quantitative contrast-enhanced ultrasound in XXXX recurrence after ablation.

@entity1 @entity2232 @entity5 @entity540 @entity3 @entity157
AIM: To investigate the relationship between contrast-enhanced ultrasound (CEUS), @entity540 ( @entity540 ), @entity2232 ( @entity2232 ), and @entity157 ( @entity157 ) recurrence after ablation. METHODS: A total of 51 @entity157 @entity1 (38 males and 13 females) who received radiofrequency ablation in our hospital from June 2012 to July 2014 were enrolled in this study. The @entity1 were divided into two groups: recurrence group and non-recurrence group. Routine abdominal examination was first performed in the horizontal position. Then the @entity1 underwent CEUS and immunohistochemical staining before receiving radiofrequency ablation. All @entity1 were followed-up every three months for one year. The results of CEUS and serum @entity5 marker levels were evaluated and combined together to estimate @entity157 recurrence and @entity3 . @entity1 were divided into two groups: recurrence group and non-recurrence group. Quantitative parameters of CEUS and @entity5 expression levels of @entity540 and @entity2232 were compared between the two groups, respectively. Binary logistic regression analysis was used to analyze the relationship between CEUS quantitative parameters, expression levels of @entity2232 and @entity540 , and @entity157 recurrence after ablation. RESULTS: Based on the quantitative parameters of CEUS before @entity1 received radiofrequency ablation, the levels of @entity5 rise time (tRT), @entity5 time to peak (tTTP), @entity5 peak intensity (tPI) and @entity5 -parenchymal peak intensity (t-pPI) in the recurrence group were significantly lower than those in the non-recurrence group (16.6    6.1 vs 23.2    7.0, P = 0.000; 41.2    10.2 vs 59.6    14.2, P = 0.000; 23.8    6.7 vs 31.4    6.4, P = 0.000; 7.1    3.4 vs 14.6    7.4, P = 0.000; respectively). The expression levels of @entity540 in the recurrence group were significantly higher than those in the non-recurrence group (P < 0.05). Levels of tTTP showed a significant inverse correlation with the level of @entity540 in @entity5 (r = -0.312, P = 0.037). The Binary logistic regression analysis results revealed that the levels of tRT, tTTP, tPI and the level of @entity540 were associated with @entity157 recurrence after radiofrequency ablation (P < 0.05). CONCLUSION: CEUS is a noninvasive and effective method for evaluating the angiogenesis of @entity157 , and predicting its recurrence and prognosis.
