XXXX coating of stents has no effect on inflammatory response to primary stent deployment.

@entity1 @entity650 @entity2002 @entity39 @entity5 @entity3979 @entity951 @entity505 @entity687 @entity1851
The aim of this study was to investigate the effects of stent @entity505 coating on inflammatory response. The authors serially measured plasma concentrations of @entity1851 ( @entity1851 ), @entity2002 , and several cytokines ( @entity5 @entity39 factor, interleukin [IL]-1-beta, @entity650 , and @entity687 ) in @entity1 with single-vessel @entity3979 who underwent primary stent implantation. None of the subjects had inflammatory or infectious disease at the time of the procedure. Forty-six @entity1 (38 males; mean age 55 +/-9 years) were studied. Blood samples were collected before and at 2, 4, 6, 24, and 48 hours after stent implantation. @entity1 were randomly assigned 1 of 2 different stent types, an uncoated MAC (AMG Raesfeld-Erle, Germany) (UC-MAC) or a @entity505 -coated MAC (CC-MAC) stent. Implantations were performed without predilatation, and stents were deployed at a maximum pressure of 6 atmospheres for 90 seconds. Of the 46 @entity1 , 14 had stable, 27 had unstable, and 5 had @entity951 . According to ACC/AHA classification, 35 lesions (76.1%) were type A, 10 (21.7%) were type B, and 1 (2.2%) was type C. Single stenosis of 28 left anterior descending, 12 circumflex, and 6 right coronary arteries were treated. Serum @entity650 increased in both the UC-MAC and CC-MAC groups, with concentrations significantly elevated above baseline at 6 hours, and then decreasing after 24 hours (baseline, 6-hour, and 24-hour values = 3.1 +/-2.3, 5.7 +/-3.8, and 6.3 +/-4.6 pg/mL, respectively, in UC-MAC; 3.7 +/-2.6, 6.2 +/-6.0, and 4.6 +/-3.7 pg/mL, respectively, in CC-MAC [p=0.002]). Plasma @entity2002 , @entity1851 , and leukocyte concentrations also increased in both groups over the 24 hours (p < 0.05). The elevations of @entity650 , @entity1851 , and @entity2002 were similar in the 2 groups. The percent increases in @entity650 , @entity2002 , and @entity1851 were not associated with stent length, size, or clinical presentation (all p > 0.05). The results showed that stent implantation increases plasma @entity650 , @entity2002 , and @entity1851 concentrations, but @entity505 coating of the stent does not seem to affect this inflammatory response.
