Analysis of results of radiation therapy for stage IB XXXX .

@entity1 @entity189 @entity3
From April of 1969 through December of 1980, 197 @entity1 with Stage IB, invasive, epidermoid @entity189 received radical radiation therapy. The treatment consisted of external beam and intracavitary therapy designed to deliver 7000 to 8000 rad to Point A and 5000 to 5500 rad to the pelvic lymph nodes. The 2-, 5-, and 10-year, disease-free survival rates were 87%, 83%, and 81%, respectively. Thirty-six @entity1 developed recurrent and/or metastatic disease. The sites that failed to remain disease-free were: locoregional in five @entity1 (3%), locoregional with distant @entity3 in 15 @entity1 (8%), and distant @entity3 only in 14 @entity1 (7%). In addition, there were two @entity1 (1%) who are considered to have died of disease but the site or sites of recurrence could not be determined. Thirty-nine @entity1 developed complications. The complications were mild and self-limiting--Grade I--in 24 @entity1 (12%) and of moderate severity--Grade II--in eight @entity1 (4%). Seven @entity1 (4%) developed severe--Grade III--complications. A correlation was found between the dose to Point A, the bladder, and the rectum and the complications. The mean dose to Point A for @entity1 without and with complications were 7453 rad (SE +/- 91) and 7737 (SE +/- 124), respectively, with a P value of .05. The mean dose to the bladder for @entity1 without and with urinary complications was 5590 rad (SE +/- 103) and 6335 rad (SE +/- 411), respectively, with a P value of 0.14. The mean dose to the rectum for @entity1 without and with intestinal complications was 5837 rad (SE +/- 103) and 6810 rad (SE +/- 236), respectively, with a P value of 0.001. No correlation was found between the dose to Point A and locoregional recurrences.
