Longitudinal CT study of parenchymal brain changes in XXXX survivors.

@entity1 @entity67 @entity5 @entity11 @entity194 @entity62
We reviewed the serial CT studies obtained between 1974 and 1986 of 31 @entity1 with @entity11 who survived for 2 to 11 years after surgical @entity5 . In all cases surgery was followed by radiation therapy to the head (6000 rad) and chemotherapy. @entity1 were divided into two age groups: those under age 40 (n = 13) and those over age 40 (n = 18). By 2 years all @entity1 in the older group developed evidence of @entity62 characterized by periventricular zones of decreased attenuation. Only 58% of the younger group showed evidence of white matter changes at this point. All @entity1 from both age groups who survived for 4 years developed @entity62 . The severity of @entity62 from 6 months after surgery and beyond was always greater in the older group. All @entity1 developed @entity194 as evidenced by sulcal dilatation and @entity67 . @entity194 was progressive beginning with the first postirradiation scan, and was always more severe in the older @entity1 . A significant difference was found in the clinical status of the two age groups as determined by the mental status score and the Karnofsky scale. Despite progressive brain changes, survivors under age 40 maintained a nearly normal mental status and Karnofsky scores until their death, whereas survivors over age 40 showed progressive clinical decline.
