The antithrombotic effects of @entity10786 filtrates in rats and XXXX .

@entity2066 @entity19 @entity2077 @entity620 @entity1881 @entity10786 @entity715
The prevention of arterial @entity715 has a high priority in developed countries. An inappropriate diet is known to enhance the risk for acute @entity715 events and a regular diet with proven antithrombotic effects might be a beneficial way to prevent disease. The present study was undertaken as a part of a series of investigations to examine vegetables and fruits for antithrombotic activity. A shear-induced in vitro platelet reactivity/thrombolysis method [Global @entity715 Test, formerly Gorog @entity715 Test] was used to screen 15 different varieties of carrot for antiplatelet and thrombolytic activities. Effective varieties were further investigated using an in vivo, laser-induced @entity715 model in @entity19 . The different @entity10786 varieties demonstrated a variable effect on @entity715 in vitro and in vivo. In particular, a variety designated SAKATA-0421 exerted an antithrombotic effect in vivo independent from heat treatment of the filtrate at 100 degrees C for 10 min. There was no significant correlation between antithrombotic activity and the levels of polyphenolics and any other biochemical parameter, including antioxidant activity, @entity2077 and @entity2066 , @entity1881 and @entity620 . Different varieties of @entity10786 demonstrated a range of antithrombotic and prothrombotic activities. After oral intake, the particular heat resistant variety (SAKATA-0421) showed antithrombotic effect in vivo possibly due to antiplatelet reactivity and/or spontaneous thrombolytic activity. The present study added a new variety to the list of antithrombotic fruits and vegetables.
