Immunoreactive gastric inhibitory polypeptide response to a meal during the first eighteen months after diagnosis of type 1 (insulin dependent) XXXX mellitus.

@entity1 @entity8242 @entity6
The changes in plasma concentrations of immunoreactive gastric inhibitory polypeptide (IR- @entity8242 ) in response to a standard meal were examined in 21 normal subjects and 15 Type 1 (insulin dependent) @entity6 @entity1 7 days, 14 days, and 3, 6, 9, 12, and 18 months after time of diagnosis. During the first 4 tests significantly lower plasma IR- @entity8242 concentrations were found in the @entity6 @entity1 after the standard meal. At 9 months and during the remaining tests there was no difference in IR- @entity8242 concentrations between the @entity6 and the normal subjects. The IR- @entity8242 response was normalized faster if the @entity6 @entity1 were treated with initial short term intensive insulin therapy than if they were treated conventionally with 1 or 2 daily injections of insulin. beta-Cell function, evaluated by the C-peptide response to the meal, increased significantly during the first 3 months. After 3 months maximal beta-cell function was found while the corresponding IR- @entity8242 responses were significantly lower than those of the normal subjects. Thereafter beta-cell function declined gradually and significantly, coinciding with the normalization of the IR- @entity8242 response. No individual covariation between IR- @entity8242 and beta-cell function during the 18 months was found in any @entity1 . The IR- @entity8242 response to a meal was diminished at the onset of Type 1 (insulin dependent) @entity6 mellitus. After the start of insulin therapy the response improved, perhaps as a function of the quality of metabolic control, and within a year it was comparable to that of normal subjects. Lack of endogenous @entity8242 therefore does not explain the diminished beta-cell function in Type 1 @entity6 a few months after onset of the disease. No causal relationship between the changes in beta-cell function and IR- @entity8242 during the first 18 months after the onset of the disease seems to exist.
