Ultrastructure of the kidney in XXXX .

@entity1 @entity8668 @entity39 @entity1372 @entity810 @entity1986 @entity616
Fifteen percutaneous renal biopsies from @entity1 with @entity810 due to @entity1986 ( @entity1986 ), in almost all cases due to drugs, were studied by electron microscopy. Differential counting of interstitial cells showed an average of 69% lymphocytes (small and large) and 11% macrophages. Plasma cells and eosinophils were comparatively rare. The infiltrate resembled that of acute rejection, suggesting a cellular hypersensitivity reaction. Proximal and distal tubules were severely affected focally. Migration of lymphocytes through the tubular basement membrane of otherwise well-preserved tubules was considered to be the first phase. Other tubules showed extreme thinning of the tubular basement membrane, with still intact cellular walls. Rupture of the tubular basement membrane and @entity39 of tubular epithelial cells are probably late phenomena. The non-necrotic tubules displayed severe @entity8668 and proximal as well as distal tubular basolateral infoldings. Focal tubular disintegration leading to @entity616 and/or backleak as well as decrease of proximal tubular @entity1372 resorption leading to a decreased glomerular filtration (a mechanism probably also acting in ischemic @entity810 ) may all be factors responsible for the @entity810 in @entity1986 .
