Radiofrequency catheter ablation for management of symptomatic XXXX .

@entity1 @entity1165 @entity1540 @entity299 @entity943
OBJECTIVES: This study assessed the useful role of intracardiac mapping and radiofrequency catheter ablation in eliminating drug-refractory monomorphic @entity1540 in severely symptomatic @entity1 . BACKGROUND: @entity1540 is commonly encountered in clinical practice. Usually, it is not associated with life-threatening consequences in the absence of significant structural @entity299 . However, frequent @entity1540 can be extremely symptomatic and even incapacitating in some @entity1 . Currently, reassurance and pharmacologic therapy are the mainstays of treatment. There has been little information on the use of catheter ablation in such @entity1 . METHODS: Ten @entity1 with frequent and severely symptomatic monomorphic @entity1540 were selected from three tertiary care centers. The mean frequency +/- SD of @entity1540 was 1,065 +/- 631 beats/h (range 280 to 2,094) as documented by baseline 24-h ambulatory electrocardiographic (ECG) monitoring. No other spontaneous @entity943 were documented. These @entity1 had previously been unable to tolerate or had been unsuccessfully treated with a mean of 5 +/- 3 antiarrhythmic drugs. The site of origin of @entity1540 was accurately mapped by using earliest endocardial activation time during ectopic activity or pace mapping, or both. RESULTS: During electrophysiologic study, no @entity1 had inducible @entity1165 . The ectopic focus was located in the right ventricular outflow tract in nine @entity1 and in the left ventricular posteroseptal region in one @entity1 . Frequent @entity1540 were successfully eliminated by catheter-delivered radiofrequency energy in all 10 @entity1 . The mean number of radiofrequency applications was 2.6 +/- 1.3 (range 1 to 5). No complications were encountered. During a mean follow-up period of 10 +/- 4 months, no @entity1 had a recurrence of symptomatic ectopic activity, and 24-h ambulatory ECG monitoring showed that the frequency of @entity1540 was 0 beat/h in seven @entity1 , 1 beat/h in two @entity1 and 2 beats/h in one @entity1 . CONCLUSIONS: Radiofrequency catheter ablation can be successfully used to eliminate monomorphic @entity1540 . It may therefore be a reasonable alternative for the treatment of severely symptomatic, drug-resistant monomorphic @entity1540 in @entity1 without significant structural @entity299 .
