Multi-parametric MRI findings of transitional XXXX : correlation with 3-dimensional transperineal mapping biopsy.

@entity1 @entity263 @entity75 @entity1067 @entity2286
UNASSIGNED: Purpose A preliminary project to correlate MR findings with mapping prostate biopsy to help differentiate malignant transitional zone lesions form @entity1067 ( @entity1067 ) nodules. Materials and Methods Institutional IRB approved retrospective study with 14 @entity1 suspected of having @entity263 who underwent both prostate 3T MRI using endorectal coil and 3D transperineal mapping prostate biopsy. MR exams were independently reviewed by two abdominal radiologists blinded to pathology with disagreement resolved by consensus. An @entity75 was defined as having hypointense T2 signal subjectively without corresponding T1 high signal intensity and low signal on ADC maps in the central gland. Mapping biopsy consisted of systematic transperineal US guided biopsy with 55-108 cores per @entity1 . Results Twenty-nine lesions were detected on MRI. Of these, 13 correlated with Gleason 6 or higher biopsy samples. 16 were biopsy negative. Among the various MRI characteristics assessed, lack of T2 hypointense rim demonstrated the highest specificity (93%) and positive predictive value (89%). Highest sensitivity (85%) and negative predictive value (78%) were seen with ill-defined nodules. When suspicious MR characteristics were combined, the specificity and @entity2286 rose to 100% while sensitivity decreased to 45% and NPV decreased to 73%. Conclusions Preliminary study indicates MR findings which can help differentiate a @entity1067 nodule from transitional @entity263 which could help direct biopsy in the large and growing number of @entity1 suspected of having @entity263 . Further work will be needed for validation.
