[Significance of the functional activity of antibodies in XXXX immunity].

@entity1 @entity683 @entity3457 @entity281
A simple and inexpensive test for mass examination of the functional activity of serum antibodies was developed. The test is based on a kinetic serologic reaction that reflects the time course of changes in antibody titers depending on the time of contact of the tested material with antigen. The curves of serum kinetic titration were processed on a computer by the special programme. As a result, an integral factor, an @entity3457 ( @entity3457 ) was calculated for each serum sample under study. The titers and @entity3457 were determined in more than 2,000 healthy @entity1 , @entity1 with @entity683 A and B, and those immunized with different @entity683 vaccines. The @entity1 having similar antibody titers were demonstrated to greatly differ in @entity3457 . The functional activity of antibodies is a more precise marker of protection from @entity683 than the routine quantitative characteristics of antibodies, i.e. titers. The high baseline @entity3457 decreased the severity of @entity281 . Live @entity683 vaccines stimulated the production of antibodies having higher @entity3457 than inactivated ones. The live @entity683 strains (candidates for vaccine ones) significantly differed in their ability to stimulate the production of antibodies having a high functional activity.
