Natural history of XXXX during active surveillance with follow-up longer than 5 years.

@entity1 @entity5 @entity1358 @entity148 @entity3 @entity204 @entity65 @entity703
OBJECTIVES: To present our experience with @entity1 who elected active surveillance for @entity703 ( @entity703 ) with >= 5 years of follow-up. Few data are available regarding the long-term natural history of @entity703 during surveillance. METHODS: We retrospectively reviewed our urologic oncology database and identified 44 @entity1 with 51 @entity703 who had received active surveillance for >5 years of follow-up. The @entity1 and @entity5 characteristics and @entity5 growth rate and overall survival data were evaluated. RESULTS: The median @entity1 age was 71.7 years (range 55-92), with 32 @entity1 (72.7%) having a Charlson comorbidity index of >= 2. The median @entity5 size was 2.67 cm (range 0.9-8.6) at diagnosis. Biopsy was performed in 17 @entity1 (38.6%). Of these 17 @entity1 , @entity1358 was diagnosed in 15 and @entity1358 in 2 @entity1 . The median follow-up was 77.1 months (range 60-137), and the median growth rate was 0.15 cm/y. Of these @entity1 , 2 (4.5%) required delayed intervention. One underwent laparoscopic radical nephrectomy because of a high @entity5 growth rate, and one elected to withdraw from active surveillance because of personal @entity148 , despite having a stable @entity5 size for 72 months. The latter @entity1 underwent laparoscopic renal cryoablation. Histopathologic examination revealed @entity1358 in both cases. No @entity3 or @entity5 -related @entity204 occurred in our cohort; 1 @entity1 died of @entity65 . CONCLUSIONS: Most @entity703 undergoing surveillance for >5 years grew slowly. The metastatic potential appeared minimal in @entity1 who demonstrated low or @entity5 growth for a long period.
