Cyclin E expression in XXXX : relation to staging.

@entity1 @entity3557 @entity5 @entity3 @entity7172
Cyclin E plays a pivotal role in the regulation of G1-S transition and relates to malignant transformation of the cells. However, the clinical significance of cyclin E expression in @entity1 with @entity3557 ( @entity3557 ) remains unknown. We examined by immunohistochemistry the expression of cyclin E in 41 resected PTCs in pathologic stages from pT1a to pT4 and analyzed its relation to clinicohistopathologic factors. The positive staining was divided into 3 grades: no expression if less than 10%, expression if 11-50% and overexpression if more than 50% of the nuclei of @entity5 cells were stained positively. Cylin E expressions were observed in 75.6% of analyzed PTCs but only 60% of @entity7172 ( @entity7172 ) were immunopositive for cyclin E expression. However, cyclin E staining was observed in 90.4% of PTCs in a group with TNM higher than pT1a. The staining index was significantly different between the @entity7172 and the rest of the @entity5 investigated (14.91% +/- 14.4% vs. 34.03% +/- 23.44%, respectively; p < 0.005) and we observed positive relation between the staining index and factor T of staging of PTCs. All the lymph node @entity3 coexisted with cyclin E expression and most, but not all, of them coexisted with cyclin E overexpression. These findings indicate that cyclin E may play a key role for the oncogenesis and biologic behavior of @entity3557 . If our results are confirmed in a larger study, a high level of cyclin E expression may become a new prognostic marker for PTCs.
