Prognostic significance of @entity2355 , @entity5091 and XXXX expressions in @entity356 .

@entity1 @entity5 @entity5091 @entity2580 @entity189 @entity4056 @entity5089 @entity3 @entity2355 @entity356
BACKGROUND/AIMS: The aim of this study was to investigate the expressions of some of the Mucus Core Proteins (MUC) @entity2355 , @entity5091 and @entity5089 in @entity356 , to assess their prognostic values and their relations with the clinicopathological characteristics. METHODS: @entity2355 , @entity5091 and @entity5089 expressions were investigated immunohistochemically in 257 @entity1 with @entity356 . RESULTS: @entity2355 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity5 differentiation (92.6% in well differentiated @entity5 , 83.7% in poorly differentiated @entity5 ), with an increase in the number of metastatic lymph nodes (98.4% in @entity5 with no metastatic lymph nodes, 67.9% in @entity5 with lymph node metastasis-pN3), and with the progression in the @entity5 stage (100% in stage 1 @entity5 , 75.6% in stage 4 @entity5 ). @entity2355 expression was lower in distant @entity3 (83.3% in distant @entity3 and 90.8% in @entity5 ). There was no staining with @entity5091 in normal gastric epithelium; however, de novo expressions appeared in tumoral tissues. In @entity356 ( @entity2580 ), @entity5091 expression was higher (97.5% in diffuse type and 89.4% in intestinal type). All of the @entity189 were @entity5091 -positive. The expression rate decreased with an increase in the number of metastatic lymph nodes and with the progression in the TNM stages of the cases. All of the @entity5 with intestinal metaplasia were @entity5091 -positive. @entity5089 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity5 differentiation, with an increase in the @entity5 invasion depth, and with an increase in the number of metastatic lymph nodes. @entity5089 expression was higher in @entity4056 (48.4%) than in the diffuse type (10%). The lowest expression rate was in the diffuse type according to the Borrmann's macroscopic classification. All of these results were statistically significant (p<0.05). CONCLUSIONS: When each of these three markers is evaluated, in the light of clinical and pathological parameters, @entity2355 and @entity5089 may be accepted as significant prognostic parameters and may be useful in showing the progression of the @entity5 ; @entity5091 may be used in determining the @entity189 .
