Diagnostic Performance of Contrast-Enhanced MRI With XXXX -Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology.

@entity1 @entity82 @entity11384 @entity348 @entity16581 @entity490 @entity285 @entity2723
OBJECTIVES: Diagnosis of @entity16581 ( @entity16581 ) in @entity1 presenting with chronic @entity490 is challenging and controversial. Contrast-enhanced magnetic resonance imaging (MRI) with @entity11384 -stimulated MRCP (sMRCP) offers a safe and noninvasive modality to diagnose mild @entity2723 , but its findings have not been correlated with histopathology. We aimed to assess the correlation of a spectrum of MRI/sMRCP findings with surgical histopathology in a cohort of @entity16581 @entity1 undergoing @entity348 ( @entity348 ). METHODS: Adult @entity1 undergoing @entity348 for @entity16581 between 2008 and 2013 were identified from our institution's surgery database and were included if they had MRI/sMRCP within a year before surgery. Histology was obtained from resected pancreas at the time of @entity348 by wedge biopsy of head, body, and tail, and was graded by a gastrointestinal pathologist who was blinded to the imaging features. A @entity82 score (FS) of 2 or more was considered as abnormal, with FS >= 6 as severe @entity82 . A multivariate regression analysis was performed for MRI features predicting @entity82 , after taking age, sex, smoking, @entity285 , and body mass index (BMI) into consideration. A quantitative receiver operating characteristic (ROC) curve analysis was performed and Spearman rank correlation coefficient (r) was calculated. RESULTS: Fifty-seven @entity1 (females=49, males=8) with @entity16581 and MRI/sMRCP were identified. ROC curve analysis showed that two or more MRI/sMRCP features provided the best balance of sensitivity (65%), specificity (89%), and accuracy (68%) to differentiate abnormal (FS>= 2) from normal pancreatic tissue. Two or more features provided the best cutoff (sensitivity 88%, specificity 78%) for predicting severe @entity82 (FS>= 6). There was a significant correlation between the number of features and severity of @entity82 (r=0.6, P<0.0001). A linear regression after taking age, smoking, and BMI into consideration showed that main pancreatic duct irregularity, T1-weighted signal intensity ratio between pancreas and paraspinal muscle, and duodenal filling after @entity11384 injection to be significant independent predictors of @entity82 . CONCLUSIONS: A strong correlation exists between MRI/sMRCP findings and histopathology of @entity16581 .
