XXXX characterized by t(8;14)(q11.2;q32).

@entity1 @entity981 @entity7513
The t(8;14)(q11.2;q32) is emerging as an uncommon, though recurrent cytogenetic finding. As of yet, too few cases of @entity981 ( @entity981 ) characterized by this translocation have been studied to determine its prognostic significance with confidence. We therefore report three new @entity1 (two male @entity1 and one adult female) and present their hematologic, immunophenotypic, and clinical data. The clinical and laboratory characteristics of 26 other @entity1 with t(8;14)(q11.2;q32) are summarized. The total number of @entity1 now reported in the literature is 29 with a mean age of 14 years. Early relapse, that is, relapse within 6 months, does not appear to be a common feature of this group. The gender distribution is 19 males: 9 females (gender not reported in one case). Twenty-three t(8;14) @entity1 show a pre-B immunophenotype and 24 of 24, on whom information is available, achieved complete remission after induction chemotherapy for B- @entity981 . Approximately one third of @entity1 with t(8;14) have Down syndrome, 19 of 27 have additional acquired cytogenetic abnormalities, 5 of these have the t(9;22), and 4 show duplication of the abnormal chromosome 14, which is derived from the t(8;14). Hemoglobin and platelet counts are low at presentation in 10 of 10 and 8 of 9 @entity1 , respectively, and the average white blood count is 38.9 x 10(9)/L. Of the 7 @entity1 for whom @entity7513 status has been determined, all show rearrangement of the @entity7513 locus. Two of the present three @entity1 are included in this group; their @entity7513 rearrangement was demonstrated by fluorescence in situ hybridization with @entity7513 break-apart probes.
