The correlation of protein peroxidation with morphological changes in experimental @entity53 -induced XXXX .

@entity1 @entity0 @entity5 @entity1373 @entity189 @entity53 @entity329 @entity105 @entity6349
@entity53 -induced male @entity329 @entity105 is a well-known experimental model of @entity1 @entity0 . The pathomechanism postulated in this model is 4-hydroxylation of @entity53 and further free radical formation. The same process is suspected in @entity1 @entity0 . Dynamic changes in protein peroxidation were reported during the @entity5 induction. In this paper we try to correlate the protein peroxidation markers with the histopathological progression of the changes. The biochemical and histopathological evaluations were performed after 1, 3, 6 and 9 months of the hormone exposition. Significant protein peroxidation was observed as soon as after 1 month and increased further until the 6th month. After 9 months however, it was not significantly different from the control. The discrete histopathological changes after 1 month, progressed into tubular and @entity1373 after 3 and 6 months. After 9 months several @entity6349 , sometimes with features of @entity189 in situ, were observed. The severe 9-month histopathological changes did not correlate with the protein peroxidation.
