Estimated glomerular filtration rate changes in XXXX with @entity1860 treated with @entity4149 kinase inhibitors.

@entity1 @entity2212 @entity8947 @entity8 @entity101 @entity6 @entity5 @entity740 @entity810 @entity1011 @entity4149 @entity1860 @entity10542 @entity2213
BACKGROUND: Chronic use of @entity4149 kinase inhibitors (TKIs) may lead to previously unrecognized adverse events. This study evaluated the incidence of @entity810 ( @entity810 ) and @entity740 ( @entity740 ) in chronic-phase (CP) @entity1860 ( @entity1860 ) @entity1 treated with @entity2213 , @entity8947 , and @entity10542 . METHODS: Four hundred sixty-eight newly diagnosed @entity2212 @entity1 treated with TKIs were analyzed. The molecular and cytogenetic response data, @entity1011 , and glomerular filtration rate (GFR) were followed from the start of therapy to the last follow-up (median, 52 months). GFR was estimated with the Modification of Diet in @entity8 equation. RESULTS: Nineteen @entity1 (4%) had TKI-associated @entity810 . @entity2213 was associated with a higher incidence of @entity810 in comparison with @entity8947 and @entity10542 (P   =   .014). Fifty-eight @entity1 (14%) developed @entity740 while they were receiving a TKI; 49 of these @entity1 (84%) did so while they were being treated with @entity2213 (P   <   .001). Besides @entity2213 , age, a history of @entity101 , and @entity6 were also associated with the development of @entity740 . In @entity1 with no @entity740 at the baseline, @entity2213 was shown to reduce GFR over time. Interestingly, @entity2213 did not cause a significant decline in the GFRs of @entity1 with a history of @entity740 . @entity2213 , @entity8947 , and @entity10542 increased the mean GFR after 3 months of treatment, and @entity10542 led with the most significant increase (P   <   .001). @entity810 or @entity740 had no significant impact on overall cytogenetic and molecular response rates or survival. CONCLUSIONS: The administration of TKIs may be safe in the setting of @entity740 in @entity2212 @entity1 , but close monitoring is still warranted. @entity5 2015;121:3894-3904.    2015 American @entity5 Society.
