Insulin-like growth factor (IGF)-I and -II and @entity12068 in @entity1 and adolescents with XXXX : correlation with metabolic control and height attainment.

@entity1 @entity6 @entity2301 @entity442 @entity10513 @entity5100 @entity1723 @entity12068 @entity214
The putative effects of @entity6 and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial. In the present study, serum levels of @entity442 and @entity5100 and @entity12068 were measured in 58 @entity1 (age, 0.8-17 yr) with treated (51 subjects) or untreated (7 subjects) @entity1723 ( @entity1723 ) and were compared with the levels in normal subjects. In the untreated @entity1 @entity442 and @entity5100 were decreased as compared with the healthy controls. In the treated diabetics @entity442 and @entity5100 were reduced; @entity10513 (only in prepubertal subjects) and @entity2301 were increased. Furthermore, age-adjusted values of @entity442 , @entity5100 , and @entity2301 were lower in prepubertal than in pubertal @entity1 . Regression analysis revealed a negative correlation between hemoglobin (Hb)A1c and standard deviation scores ( @entity214 ) of @entity442 and a positive association between HbA1c and IGFBP-1 @entity214 or @entity10513 @entity214 . In the treated @entity1 HbA1c was positively related to IGFBP-1 @entity214 and @entity10513 @entity214 when applying simple regression analysis and to @entity10513 @entity214 when using a multiple regression model. Strong correlations were observed between height @entity214 and @entity442 @entity214 , @entity5100 @entity214 , and @entity2301 @entity214 in prepubertal subjects who had had @entity1723 for at least 2 yr, but not in adolescents. Such correlations have also been found in healthy @entity1 and adolescents. In conclusion; 1) @entity1723 is associated with alterations of the IGF-IGFBP system, which are partially accounted for by differences in metabolic control and pubertal status; 2) the lower plasma concentrations of serum @entity442 may play a role in the pathogenesis of growth impairment of poorly controlled prepubertal, but not pubertal, @entity1 and adolescents with @entity1723 ; and 3) in addition, a potential role of the altered IGF-IGFBP system for the development of @entity6 late complications is hypothesized.
