Reduction in @entity715 extension and clinical end points in XXXX after initial treatment for @entity1150 with the fixed-dose body weight-independent low molecular weight heparin certoparin.

@entity1 @entity37484 @entity548 @entity49 @entity1150 @entity1031 @entity715 @entity1211
Low molecular weight heparin (LMWH) is effective in the treatment of acute @entity1150 ( @entity1150 ) in adults. This has not been demonstrated for one LMWH alone. The relationship between venographic changes due to LMWH therapy and clinical outcome in the initial treatment period has not been reported. A pooled analysis of two clinical trials was performed. The trials compared a fixed-dose, body weight-independent, subcutaneous LMWH, @entity37484 (8000 antifactor Xa [aXa] U twice a day [b.i.d.]), with an adjusted-dose intravenous unfractionated heparin (UFH) with respect to venographic changes expressed as Marder score and occurrence of recurrent @entity1211 , major @entity548 , and mortality. The Marder score was 23.2 +/- 8.4 in @entity1 randomized to LMWH (n = 299 paired phlebograms) and 23.9 +/- 8.9 in @entity1 allocated to UFH (n = 297 paired phlebograms) at entry (2p = 0.23) and 18.9 +/- 9.7 and 20.5 +/- 9.9 at the end of the initial therapy (2p = 0.04), respectively. The composite outcome of recurrent @entity1211 , major @entity548 , and mortality occurred less frequently during treatment with LMWH (n = 393) than it did with UFH (n = 404, 1.3% versus 5.0%, risk reduction [RR] 0.26, 95% confidence interval [CI] 0.11 to 0.63, 2p = 0.004). Single events of recurrent @entity1031 (2p = 0.12), major @entity548 (2p = 0.03), and mortality (2p = 0.12) were observed less frequently with LMWH. A trend toward a lack of regression of @entity715 size was observed in recurrent @entity1211 (2p = 0.08). Body weight-independent LMWH significantly reduces @entity715 size and the incidence of composite outcome during the initial treatment of acute proximal @entity49 compared with adjusted dose intravenous UFH. The data indicate a relation between an unimproved Marder score and a recurrent @entity1211 .
