Effect of treatment on the prognostic value of S-phase fraction in XXXX .

@entity1 @entity632 @entity9107 @entity706 @entity5 @entity229 @entity3726 @entity786 @entity10359 @entity1891 @entity1893
PURPOSE: To investigate the prognostic value of cell proliferation rate in @entity1893 , study its association with histologic classification, and investigate whether its predictive value is influenced by the type of treatment given. @entity1 AND METHODS: The S-phase fraction ( @entity10359 ) size was determined by DNA flow cytometry from paraffin-embedded tissue obtained at diagnosis from 490 @entity1 with @entity1893 , diagnosed in a defined geographic area from 1970 to 1991. Clinical data were collected from hospital records and the files of the Finnish @entity5 Registry. RESULTS: @entity10359 size correlated well with histologic grading performed either according to the Working Formulation or Kiel classification (P < .0001 for both). The mean SPFs of low-, intermediate-, and high-grade @entity706 were 4.9% (95% confidence interval [CI], 4.2% to 5.5%), 10.3% (95% CI, 9.3% to 11.4%), and 15.5% (95% CI, 14.0% to 16.9%), respectively. Lymphomas with an @entity10359 lower than the median (7.9%) had a 58% 5-year and 44% 15-year survival rate, whereas those with an @entity10359 larger than the median had a 44% 5-year and 40% 15-year survival rate (P < .0001). @entity10359 size was not significantly associated with prognosis in some subgroups, such as among @entity1 treated primarily with @entity786 , @entity632 , @entity1891 , and @entity229 ( @entity3726 ) (n = 114) or @entity786 , @entity1891 , and @entity229 ( @entity9107 ) (n = 124) with or without radiotherapy (P > .05), whereas a stronger association was found among @entity1 with stage I or @entity706 treated with radiotherapy only (n = 100; P = .003) and among @entity1 with stage III or IV @entity706 who did not receive chemotherapy (n = 44; P < .0001). In multivariate analyses that included the factors used to construct the International Prognostic Index, @entity10359 had independent prognostic value both in low-grade and intermediate- or high-grade @entity706 , but not in the subset of @entity1 treated with combination chemotherapy with or without radiotherapy. CONCLUSION: Cell proliferation rate measured as @entity10359 is closely associated with histologic grading in @entity1893 , and it has independent prognostic value. The treatment given influences considerably the prognostic value of @entity10359 .
