Prostaglandin F2 alpha and XXXX in experimental hypogalactia in sows.

@entity18314 @entity1496 @entity1420 @entity1021 @entity4090 @entity7042
Peripheral plasma concentrations of @entity18314 (PGFM), @entity1420 , @entity4090 and @entity7042 were determined in 20 sows for two days before and three weeks after parturition. Groups of four sows each received one of the following five treatments post partum: 30 ml sterile 0.9 per cent saline solution intrauterinely; ovariectomy and 30 ml saline solution intrauterinely; 10 ml Lugol's @entity1496 plus 20 ml saline solution intrauterinely; ovariectomy and 10 ml Lugol's @entity1496 plus 20 ml saline solution intrauterinely, or @entity1420 (0.5 mg [kg bodyweight]-1 intramuscularly). Saline solution and @entity1496 were administered every 48 hours, @entity1021 immediately after parturition, for one week. Ovariectomy was performed within eight hours of delivery. @entity1420 was given every third day for 12 days. Piglet weight gains were used as a reflection of milk yield. In all sows, @entity7042 values were elevated before parturition, but fell by the end of delivery and were very low during lactation. PGFM concentrations rose during the last two days of pregnancy to reach maximal values at the time of delivery. Plasma @entity1420 levels declined concomitantly with the rise in PGFM values before parturition. Basal values of @entity1420 were achieved within 24 hours after delivery in control sows receiving saline treatment. @entity1420 values fell immediately after ovariectomy in sows receiving saline or @entity1496 treatment but were slightly elevated for one week in sows that received only intrauterine @entity1496 treatment, suggesting that complete regression of corpora lutea is prevented by suppression of post parturient uterine prostaglandin production. Sows injected with @entity1420 maintained plasma values of about 5 to 15 nmol litre-1.(ABSTRACT TRUNCATED AT 250 WORDS)
