XXXX influences insula and amygdala activation during anticipation of emotional images.

@entity11974 @entity1246 @entity1245 @entity148 @entity460 @entity750 @entity4481
@entity4481 ( @entity11974 ) has shown potential as an anxiolytic for treatment of generalized and @entity148 . @entity11974 binds to voltage-dependent @entity460 channels, leading to upregulation of @entity1246 inhibitory activity and reduction in the release of various neurotransmitters. Previous functional magnetic resonance imaging (fMRI) studies indicate that selective @entity750 reuptake inhibitors and @entity1245 attenuate amygdala, insula, and medial prefrontal cortex activation during anticipation and emotional processing in healthy controls. The aim of this study was to examine whether acute @entity11974 administration would attenuate activation in these regions during emotional anticipation. In this double-blind, placebo-controlled, randomized crossover study, 16 healthy controls completed a paradigm involving anticipation of negative and positive affective images during fMRI approximately 1   h after administration of placebo, 50, or 200   mg @entity11974 . Linear mixed model analysis revealed that @entity11974 was associated with (1) decreases in left amygdala and anterior insula activation and (2) increases in anterior cingulate (ACC) activation, during anticipation of positive and negative stimuli. There was also a region of the anterior amygdala in which @entity11974 dose was associated with increased activation during anticipation of negative and decreased activation during anticipation of positive stimuli. Attenuation of amygdala and insula activation during anticipatory or emotional processing may represent a common regional brain mechanism for anxiolytics across drug classes. @entity11974 induced increases in ACC activation could be a unique effect related to top-down modulation of affective processing. These results provide further support for the viability of using pharmaco-fMRI to determine the anxiolytic potential of pharmacologic agents.
