Abnormal blood monocytes in XXXX .

@entity1 @entity465 @entity1072
Blood monocytes were analyzed in 28 @entity1 with @entity1072 without previous cytotoxic therapy and without recent infection. Using monoclonal antibodies and flow cytometry, monocytes identified by LeuM3 or My4 were low in percentage (2.3%), but absolute numbers were increased in many @entity1 with values exceeding the normal range (120 to 510/microliter) in seven of 28 @entity1 . Monocytosis was more prominent in @entity1 with high leukemic counts, but there was no correlation to clinical stages. Monocytopenia was evident with less than 50 LeuM3+ cells/microliter in three @entity1 . Two-color fluorescence was used for the analysis of cell surface expression of major histocompatibility complex (MHC) Class II molecules, complement receptors, and Fc receptors on the LeuM3+ monocytes. Compared to cells from control donors, there was an increase for MHC class II antigens, complement receptors, and Fc receptors on the monocytes in @entity1072 , in terms of both the percentage of positive cells among the LeuM3+ monocytes and of fluorescence intensity. This increase was not restricted to @entity1 with monocytosis nor were the molecules always upregulated concomitantly. The increase of antigen expression on LeuM3+ monocytes was more than 50% (1.5-fold) in seven of 22 @entity1 for MHC Class II antigens, in seven of 16 @entity1 for complement receptor and in six of 12 @entity1 for Fc receptor. A similar decrease of antigen expression was observed only in one @entity1 for MHC Class II and in one @entity1 for complement receptor expression. Monocytosis and increased expression of monocyte cell surface antigens described for a large portion of @entity1 might be causally involved in the @entity465 in @entity1072 .
