Is the XXXX proto-oncogene involved in the pathogenesis of @entity528 type B?

@entity8958 @entity1 @entity3002 @entity1963 @entity600 @entity528
@entity1963 ( @entity1963 ) is defined by the absence of intramural ganglia of Meissner and Auerbach along variable lengths of the gastrointestinal tract. @entity528 ( @entity528 ) type B is characterized by the @entity600 of the parasympathetic submucous plexus of the gut. A connection appears to exist between these two @entity3002 . Due to the major role played by the @entity8958 proto-oncogene in @entity1963 , we sought to determine whether this gene was also related to INDB. dHPLC techniques were employed to screen the @entity8958 coding region in 23 @entity1 presenting with INDB and 30 @entity1 with a combined @entity1963 +INDB phenotype. In addition, eight @entity8958 single nucleotide polymorphisms (SNPs) were strategically selected and genotyped by TaqMan technology. The distribution of SNPs and haplotypes was compared among the different groups of @entity1 (INDB, @entity1963 +INDB, @entity1963 ) and the controls. We found several @entity8958 mutations in our @entity1 and some differences in the distribution of the @entity8958 SNPs among the groups of study. Our results suggest an involvement of @entity8958 in the pathogenesis of intestinal INDB, although by different molecular mechanisms than those leading to @entity1963 . Further investigation is warranted to elucidate these precise mechanisms and to clarify the genetic nature of INDB.
