XXXX recurrence in the remnant urothelium of females undergoing radical cystectomy for transitional cell @entity150 : long-term results from a single center.

@entity1 @entity3484 @entity8214 @entity5 @entity150
PURPOSE: We analyzed the risk factors and incidence of secondary @entity8214 of the remnant urothelium in @entity1 following radical cystectomy for @entity8214 of the bladder. MATERIALS AND METHODS: A total of 85 @entity1 with a mean age of 64.5 years with clinically localized @entity8214 of the bladder underwent radical cystectomy between 1992 and 2004. Orthotopic bladder substitution was performed in 46 females, while 39 underwent nonorthotopic urinary diversion. Of the entire cohort 22 (26%) @entity1 underwent cystectomy for multifocal or recurrent @entity8214 . Followup examinations were performed at 6-month intervals. RESULTS: Mean followup in the entire cohort was 49.8 months (median 42). Intraoperative frozen sections obtained from the urethra and distal ureters were negative for @entity8214 and CIS in all @entity1 . Four @entity1 (4.7%) had @entity8214 in the remnant urothelium at a mean of 56 months postoperatively. These @entity1 had undergone cystectomy for multifocal or recurrent @entity8214 (4 of 22 or 18%). No secondary @entity8214 was seen in the 63 @entity1 with solitary invasive or nonrecurrent @entity150 (p <0.05). Urethral recurrence was found in 2 @entity1 (4.3%) 65 and 36 months after orthotopic neobladder surgery, respectively. In the orthotopic group 1 @entity1 (2.1%) had an @entity3484 76 months after surgery, while in the nonorthotopic group 1 (2.5%) was found to have an @entity3484 48 months postoperatively. CONCLUSIONS: Recurrent or multifocal @entity8214 may represent a risk factor for secondary @entity8214 of the remnant urothelium after cystectomy. In our series all recurrent @entity5 were late recurrences (more than 36 months postoperatively). Because the rate of urethral recurrence in the current series corresponds to that reported in @entity1 (2% to 6%), urethra sparing cystectomy with orthotopic bladder replacement does not appear to compromise the oncological outcome in @entity1 .
