Overexpression of @entity13525 in XXXX .

@entity5438 @entity986 @entity24113 @entity13525 @entity994
BACKGROUND: The pathogenesis of @entity24113 ( @entity24113 ) is not well understood. SKs are slow growing, but the details of cell cycle control in these lesions are not known. We hypothesized that cyclin-dependent kinase inhibitors would be strongly expressed in SKs and that the proliferation rate would be low. OBJECTIVES: To quantify the expression of Ki67, @entity986 ( @entity986 ), @entity994 ( @entity994 ), and @entity5438 ( @entity13525 )in @entity24113 . METHODS: We assessed acanthotic SKs (n=10) and irritated SKs (n=10) for Ki67, @entity986 ( @entity986 ), @entity994 ( @entity994 ), and @entity5438 ( @entity13525 )expression using immunohistochemistry. RESULTS: For nonirritated acanthotic pattern SKs, the Ki67 index was 3.4% (range 0.6-6.5%), confirming a low proliferation rate. The @entity986 ( @entity986 ) index was 6.0% (range 0-16%), and the @entity994 ( @entity994 ) index was 4.8% (range 0-25%). @entity5438 ( @entity13525 ) was strongly and diffusely expressed in all SKs, with a labeling index of 78% (range 75-85%). The labeling indices were similar in irritated @entity24113 lesions with a slightly increased proliferation rate and corresponding decrease in @entity5438 ( @entity13525 ) expression. CONCLUSIONS: We conclude that in SKs, strong expression of the cyclin-dependent kinase inhibitor @entity5438 ( @entity13525 ) appears to be a major mechanism controlling keratinocyte proliferation.
