Prognostic value of Chinese race in XXXX .

@entity1 @entity286 @entity5 @entity189
PURPOSE: @entity189 is rare in the United States and common in southern China. Evaluating American @entity1 treated using a uniform technique and staged with CT scanning, we determined whether Chinese and non-Chinese @entity1 differ in presentation and outcome. METHODS AND MATERIALS: Between 1979 and 1996, 172 @entity1 treated at Massachusetts General Hospital received primary radiotherapy with curative intent for @entity189 . Forty-one @entity1 (24%) were of Chinese descent, and 41% of @entity5 were classified as having lymphoepithelioma histologic features. Most @entity1 received twice-daily radiotherapy and a brachytherapy boost, receiving a median dose of 72 Gy to the nasopharynx. RESULTS: At the initial presentation, the Chinese @entity1 were significantly younger, less likely to smoke, more likely to have Stage IV disease, and more likely to have @entity5 with lymphoepithelioma histologic features. After controlling for stage, age, histologic type, and treatment variables, Chinese @entity1 were significantly more likely to develop distant metastases (p <0.05). Although Chinese race does not predict for local control or overall survival, a younger age, continued @entity286 use, total radiation dose, and lymphoepithelioma histologic features do. CONCLUSION: In a large retrospective analysis of @entity189 , Chinese and non-Chinese @entity1 differed significantly in presentation-age, stage, and histologic features-and outcome. We suggest as an explanation differences in intrinsic @entity5 biology rather than differences in treatment techniques or staging systems. Additional trials in endemic countries are needed to confirm the optimal treatment of Chinese and Chinese-American @entity1 .
