@entity101 in middle-aged @entity1 . Management, morbidity and prognostic factors during long-term XXXX care.

@entity1 @entity644 @entity712 @entity64 @entity101 @entity633 @entity951 @entity613 @entity299 @entity1011 @entity65 @entity165
The effects of long-term (10 years) management at a special out- @entity1 @entity101 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity65 have been studied in 686 middle-aged male @entity101 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity101 @entity1 were derived from a random sample of @entity1 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity1 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity1 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity633 , serum @entity1011 ) involvement remained unchanged or increased slightly during follow-up. @entity951 ( @entity951 ), @entity613 ( @entity613 ) and @entity712 ( @entity712 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity951 ), 0.6% ( @entity613 ) and 0.6% ( @entity712 ). ECG signs indicating subclinical @entity299 were risk factor for @entity951 and @entity712 . Smoking was an independent risk factor for any one of these @entity65 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity64 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity165 , @entity951 and @entity644 . A previous @entity64 , smoking and @entity644 were independently associated with @entity64 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)
