Effect of standard doses of XXXX on myocardial @entity26 delivery and utilization during cardiopulmonary resuscitation.

@entity1707 @entity296 @entity1425 @entity26 @entity2224 @entity1167
This preliminary study was conducted to evaluate the effects of 0.02 mg/kg of @entity1425 (E) on @entity296 ( @entity296 ), myocardial @entity26 consumption (MVO2), and delivery (MDO2) when administered during CPR after 10-min @entity1167 . Five miniature @entity1707 were instrumented for @entity296 measurements using tracer microspheres. @entity2224 was induced. After 10 min, CPR was begun with a pneumatic compressor. Measurements of @entity296 , arterial, and coronary sinus blood gases were made. After 3 min of CPR, each animal received 0.02 mg/kg of E. The measurements were repeated and defibrillation was attempted. During CPR, MDO2 and MVO2 were 0.2 +/- 0.3 and 0.2 +/- 0.3 ml/min/100 g tissue, respectively. The myocardial @entity26 extraction ratio (ER) was 94.2 +/- 3.0%. After 0.02 mg/kg of E, MDO2 was 1.1 +/- 1.4, MVO2 was 1.0 +/- 1.3, and ER was 93.9 +/- 0.7% (p greater than .05). There were no successful defibrillations. These data indicate that MDO2 improves slightly during CPR after 0.02 mg/kg of E, but it does not meet the @entity26 demands of the fibrillating heart.
