Angiogenesis in XXXX : is it associated with parameters of prognostic significance?

@entity5 @entity1 @entity0 @entity3
Recent experimental and clinical studies suggest that @entity5 -induced angiogenesis may be an important step in the evolution of @entity5 , and may be related to prognosis. In our study we examined 42 cases of @entity0 (mean age: 56.76 +/- 13.5), 21 with lymph node @entity3 and 21 without. Angiogenesis was evaluated after immunohistochemical staining of @entity5 vessels, using polyclonal antibody to factor VIII related antigen (VIIIR-Ag) and counting of the three most active areas of neovascularization. In the same manner we counted the microvessels in lymph node @entity3 . The mean vessel count of node-negative cases (51.16 +/- 19.32) did not differ significantly from node-positive cases (45.66 +/- 17.44). In contrast @entity1 younger than 50 years had much higher mean vessel counts (54.04 +/- 16.47) than did @entity1 older than 70 years (38.03 +/- 16.73) producing a P value of < or = 0.05. No association was found between @entity5 size and mean vessel count, nor was there any significant difference between grade I (45.94 +/- 16.54), grade II (53.13 +/- 23.22) and @entity5 (51.71 +/- 20.64). When we compared the mean vessel count of primary @entity5 with those of node @entity3 , we found much lower counts in the latter (P < or = 0.01). The differences in our results from previous studies, probably reflect the heterogeneity which exists between different @entity5 in their ability to induce angiogenesis. Additionally, there is some evidence in our study that angiogenesis is possibly related to @entity1 age and probably depends on differences in the @entity5 stroma.
