Lymphocyte predominance XXXX . A clinicopathologic reassessment.

@entity1 @entity978 @entity5
A clinicopathologic analysis of 35 cases of @entity978 ( @entity978 ) was performed, and the relationship between various histologic features and stage at presentation was examined. The series comprised 31 male and 4 female @entity1 with a median age of 32 years. Twenty @entity1 had Ann Arbor Stage I disease; 5, Stage II; 8, Stage III; and 2, Stage IV. Eight cases showed a multifocal epithelioid histiocytic reaction; six of these had @entity5 (P = 0.003). Five cases contained relatively frequent atypical mononuclear cells; four of these were Stage III or IV (P = 0.017). A purely diffuse growth pattern was also associated with high stage (P = 0.031). Presence of nodularity correlated with low stage (P = 0.031). During follow-up (median, 4 years; range, 2.5 months-18 years) there was a high incidence of second @entity5 (2 large cell lymphomas, 3 non-hematologic @entity5 ). @entity978 manifests greater diversity of stage at presentation than originally thought. A high content of epithelioid histiocytes, relatively frequent atypical mononuclear cells, and diffuse histology appear to define subsets associated with @entity5 . The correlation of nodular growth pattern with low-stage disease is consistent with the distinctive behavior and derivation of nodular @entity978 .
