Serial measurement of static and dynamic cerebrovascular autoregulation after XXXX .

@entity1 @entity1545 @entity131 @entity932 @entity72359 @entity528
BACKGROUND: In @entity1 with @entity528 , the knowledge of the status of cerebrovascular autoregulation can help to optimize the management of the cerebral perfusion pressure. This study characterizes dynamic and static cerebrovascular autoregulation during the first 7 days after severe @entity131 or @entity932 . METHODS: After approval from the IRB, 16 @entity1 were studied. Cerebral blood flow velocity (CBFV) was measured daily for the assessment of dynamic (10 @entity1 ) and static (16 @entity1 ) cerebrovascular autoregulation in both the middle cerebral arteries using the transcranial Doppler sonography. Dynamic cerebrovascular autoregulation ( @entity72359 ) was measured using the cuff-deflation method and was expressed by the index of the @entity72359 . The index of the static cerebrovascular autoregulation (sAR) was calculated from changes in the CBFV in relation to drug-induced alterations of the arterial blood pressure. For statistical analyses, t test and mixed effect model were used. RESULTS: Both @entity72359 and sAR after @entity1545 were impaired in most of the @entity1 . The chronologic sequence of the @entity72359 at the ipsilateral injured hemisphere showed a significant decrease until day 4 followed by an incomplete recovery (P < 0.002). Changes in sAR were similar, however, they did not gain statistical significance. CBFV was lower at day 1-2 after injury in comparison with day 4 to 7 (P < 0.02). CONCLUSION: Daily measured @entity72359 and sAR were impaired after @entity1545 with a nadir on day 4 and consecutive incomplete recovery over time.
