Effect of low-dose XXXX on D-dimer levels during sickle cell @entity432 : a brief report.

@entity1 @entity2002 @entity1862 @entity3458 @entity158 @entity432 @entity1229
OBJECTIVE: To evaluate the activation of clotting systems in @entity1 with @entity3458 ( @entity3458 ) by measuring the plasma D-dimer level and to determine the effect of low-dose @entity1229 on D-dimer level during @entity432 . METHODS: Plasma D-dimer level was measured in 65 blood samples of 37 adult @entity1 with @entity3458 who were hospitalized for vaso-occlusive @entity158 . D-dimer level of @entity1 who were on low-dose @entity1229 was compared with those @entity1 who were not on any anticoagulation treatment. Analysis of variance (anova) was carried out to determine factors significantly associated with low D-dimer level in @entity1 with @entity3458 . The following factors were included in the anova model; @entity1229 , homozygous hemoglobin S, history of blood transfusion in past 3 months, @entity1862 , hemoglobin S%, hemoglobin F%, white blood cell counts, hemoglobin level, platelet count, and plasma @entity2002 level. RESULTS: Overall median D-dimer level in 65 samples was 2.7 microg @entity2002 equivalent units (FEU)/mL (0.34-4). @entity1 who were on low-dose @entity1229 had a median D-dimer level of 0.81 microg FEU/mL (0.34-1.8) compared with 3.1 microg FEU/mL (0.94-4) in those @entity1 who were not on anticoagulation treatment. Using anova to model D-dimer levels, only @entity1229 was significantly correlated with low D-dimer levels after controlling for other variables. CONCLUSIONS: @entity1 with @entity3458 during vaso-occulsive @entity158 have an elevated D-dimer level. Low-dose anticoagulation treatment is associated with a significant reduction in the D-dimer levels.
