The role of lung inflation in airway hyperresponsiveness and in XXXX .

@entity1 @entity565 @entity2490 @entity1224
@entity1224 ( @entity1224 ) is a fundamental phenomenon in @entity565 that can explain many aspects of the clinical manifestations of the disease. Several theories on the mechanisms of @entity1224 have been proposed, but the true nature of this problem is yet to be defined. During the past decade, the role of lung inflation in airway physiology and its relationship to @entity1224 have attracted major attention. Deep inspirations are known to exert strong beneficial effects on the airways of healthy @entity1 . These effects appear to be of dual nature: bronchoprotective and bronchodilatory. The bronchoprotective effect of deep inspiration is lost in @entity565 , even in mild disease. It is also lost in individuals with @entity2490 and @entity1224 , but no @entity565 . Therefore, the loss of bronchoprotection is related to @entity1224 . The bronchodilatory effect of deep inspiration is somewhat reduced in mild @entity565 and is only lost in severe disease, in the presence of significant @entity1224 . Current research is focused on the elucidation of the physiologic mechanisms behind lung inflation-induced bronchoprotection and bronchodilation and on the causes of their loss. This information could open new horizons in @entity565 therapy and prevention.
