The role of @entity22 in physical inactivity and its relationship to XXXX .

@entity27 @entity25 @entity28 @entity22
Natural selection defined our genotype as athletes who sleep 8-9 h each night. Physical activity and sleep exhibit positive synergy, whereby each optimizes quality of and capability for the other. Our sedentary, sleep-restricted lifestyle conflicts with our genotype to generate pathophysiologic phenotypes, especially @entity28 . Insufficient sleep is pandemic, and other @entity25 are increasingly common. @entity22 promotes @entity28 due to inactivity from sleepiness and to metabolic changes. Obesity is the primary risk factor for @entity27 , which commonly disrupts sleep. This represents one of many pathophysiologic vicious cycles involving inactivity, @entity25 , and @entity28 . Solutions include better education of the medical community, which remains surprisingly ignorant about these disease processes and therapeutic advantages of exercise and sleep repletion. Doctors commonly prescribe medications with @entity25 or weight-gain side effects instead of lifestyle modifications. Lifestyle improvements often provide superior treatment to medications and impose no side effects.
