Initiation of salvage therapy for XXXX .

@entity1 @entity263 @entity5 @entity4623 @entity1486
Physicians and @entity1 have variable and individual levels of comfort regarding when to begin salvage therapy for rising @entity1486 ( @entity1486 ) after definitive treatment of @entity263 . The decision to start salvage therapy is a multifactorial process for which few rigorous data or guidelines exist. A questionnaire survey of urologists of the Department of Defense (DoD) Center for @entity4623 Research (CPDR) was undertaken to obtain current perspectives on when to begin salvage therapy for biochemical failure after definitive therapy. Variables of age, grade, @entity5 , nodal status, performance status, latency since prior therapy, @entity1486 velocity, and ploidy were prioritized in four clinical situations; subsequent questions assessed consensus @entity1486 cut-offs for beginning adjuvant therapy in 84 clinical scenarios. Consensus on @entity1486 cut-off points was limited to postoperative radiotherapy (RT), where values of 1.0-1.5 were the mean cut-off points. CPDR urologists consider salvage prostatectomy post-RT only for @entity1 <70-y-old with node negative, grade 2-7 disease and excellent performance status. Ploidy was not generally considered useful in any scenario. Many variables in addition to @entity1486 level are involved in the decision of when to commence adjuvant therapy for initial biochemical failure. These are strikingly interdependent, and few clear absolutes are evident from this questionnaire. This is a point of necessary further research and continued discussion among physicians caring for these @entity1 .
