Periprocedural XXXX for the Prevention of Contrast-Induced Acute Kidney Injury: A Systematic Review and Meta-analysis.

@entity1 @entity23191 @entity8
BACKGROUND: @entity23191 provides a protective effect on @entity8 ( @entity8 ) in animal models. However, the reports on the efficacy of @entity23191 for the prevention of @entity8 in @entity1 remain unclear. AIMS: The objective of this meta-analysis was to assess the effect of @entity23191 for the prevention of @entity8 . MATERIALS AND METHODS: Comprehensive literature searches were performed using MEDLINE, EMBASE, and Cochrane Database from inception through February 2015. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of @entity8 in @entity1 who received @entity23191 versus those who did not were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Four studies (2 randomized controlled trials and 2 cohort studies) with 543 @entity1 were included in our analysis to assess the risk of @entity8 and the use of @entity23191 . @entity1 in the @entity23191 group had an overall lower incidence of @entity8 (14.4%) compared to the control group (18.4%). The pooled RR of @entity8 in @entity1 receiving @entity23191 was 0.66 (95% CI: 0.38-1.15, I (2) = 0). When meta-analysis was limited only to randomized control trials (RCTs), the pooled RR of @entity8 in @entity1 receiving @entity23191 was 0.79 (95% CI: 0.35-1.79, I (2) = 0%). CONCLUSIONS: Despite no statistical significance, there was a trend toward reduced @entity8 risk in @entity1 receiving @entity23191 . The findings of our meta-analysis suggest the need of a large RCT with very careful attention to the balance of benefits and harms.
