High Dose Radiation Therapy Concurrent with Chemotherapy in Locally Advanced XXXX .

@entity1 @entity326 @entity5 @entity900 @entity3147 @entity1487
PURPOSE: Here, our results from a prospective treatment protocol of concurrent radiochemotherapy (CRCT), which was conducted for locally advanced @entity5 , between April 1994 and May 2001, are reported. MATERIALS AND METHODS: A total of 52 consecutive eligible @entity1 were accumulated for this protocol. The median radiation doses to the primary site, involved nodes and uninvolved neck were 72, 61.2 and 45 Gy, using a serial shrinking field technique. The boost techniques were 3-dimensional conformal radiation therapy in 45, intracavitary brachytherapy in 3 and 2-dimensional radiation therapy, with multiple small fields, in 2 @entity1 . Two chemotherapy regimens were used: the first regimen, used in 8 @entity1 during the earlier part of the study duration, consisted of 2 cycles of @entity900 plus @entity1487 every 4 weeks, with concurrent radiation therapy, and 4 cycles with the same agents every 4 weeks, adjuvantly; the second regimen, used in 44 @entity1 during the later part, consisted of 3 cycles of @entity900 every 3 weeks, with concurrent radiation therapy and 3 cycles of adjuvant @entity900 plus @entity1487 every 3 weeks. RESULTS: The median follow-up period of the survivors was 32 months. The male to female ratio was 36/16, with a median age of 48 years. The stages, according to the new AJCC staging system (1997), were IIb in 6, III in 23, IVa in 14 and IVb in 9 @entity1 . Fifty and 32 @entity1 completed the planned radiation therapy and concurrent chemotherapy, respectively. Two @entity1 died, 1 of @entity326 during the CRCT and the other of @entity3147 during the adjuvant chemotherapy. There were 12 failures in 11 @entity1 : 7 locoregional recurrences, 1 within and 6 outside the radiation target volume, and 5 distant metastases. The locoregional control, disease-free survival and overall survival rates were 84.3, 78.8 and 92.8% at 3 years, respectively. CONCLUSION: High dose radiation therapy, coupled with concurrent chemotherapy, was judged a highly effective treatment for locally advanced @entity5 .
