XXXX Promotes the Inflammatory Response and Stemness Features in Visceral Fat Stem Cells from Obese Subjects.

@entity1 @entity32 @entity28 @entity1144 @entity519 @entity1386
UNASSIGNED: Low-grade chronic @entity32 is a salient feature of @entity28 and many associated disorders. This condition frequently occurs in @entity1144 and is connected to alterations of the visceral @entity1386 ( @entity1386 ) microenvironment. Understanding how @entity28 is related to @entity32 may allow the development of therapeutics aimed at improving metabolic parameters in @entity28 @entity1 . To achieve this aim, we compared the features of 2 subpopulations of adipose-derived stem cells (ASC) isolated from both @entity1386 of @entity28 @entity1 with the features of 2 subpopulations of ASC from the same isolation sites of @entity28 individuals. In particular, the behavior of ASC of @entity28 subjects during @entity519 , which occurs in @entity28 and is an inducer of the inflammatory response, was evaluated. @entity28 deeply influenced ASC from visceral @entity1386 (obV-ASC); these cells appeared to exhibit clearly distinguishable morphology and ultrastructure as well as reduced proliferation, clonogenicity and expression of stemness, differentiation and @entity32 -related genes. These cells also exhibited a deregulated response to @entity519 , which induced strong tissue-specific NF-kB activation and an NF-kB-mediated increase in inflammatory and fibrogenic responses. Moreover, obV-ASC, which showed a less stem-like phenotype, recovered stemness features after @entity519 . Our findings demonstrated the peculiar behavior of obV-ASC, their influence on the @entity1144 microenvironment and the therapeutic potential of NF-kB inhibitors. These novel findings suggest that the deregulated hyper-responsiveness to @entity519 stimulus of ASC from visceral @entity1386 of @entity28 subjects may contribute via paracrine mechanisms to low-grade chronic @entity32 , which has been implicated in @entity28 -related morbidity. This article is protected by copyright. All rights reserved.
