XXXX Incidence in the United States, 1977-2011: Distinct Patterns by Histology and Behavior.

@entity1 @entity6461 @entity2735 @entity5 @entity957 @entity420
BACKGROUND: Although @entity957 ( @entity6461 ) and @entity420 ( @entity420 ) are generally combined in @entity5 surveillance, their etiologies likely differ. Here, we describe demographic characteristics and trends in incidence rates (IR) of @entity5 by histology ( @entity6461 , @entity420 ) and behavior (invasive, in situ) in the United States. METHODS: With data from the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated age-adjusted @entity5 IRs across behavior/histology by demographic and @entity5 characteristics for 2000-2011. Trends in IRs and annual percent changes during 1977-2011 were also estimated and compared with @entity5 . RESULTS: @entity1 had higher rates of @entity6461 [rate ratio (RR), 1.45; 95% confidence interval (CI), 1.40-1.50] and lower rates of @entity420 (RR, 0.68; 95% CI, 0.62-0.74) and @entity957 in situ ( @entity2735 ; RR, 0.36; 95% CI, 0.34-0.38) than @entity1 . Blacks had lower rates of @entity6461 (RR, 0.82; 95% CI, 0.77-0.87) and @entity2735 (RR, 0.90; 95% CI, 0.83-0.98) than non-Hispanic whites, but higher rates of @entity420 (RR, 1.48; 95% CI, 1.29-1.70). @entity5 IRs were higher in @entity1 and blacks aged <40 years. During 1992-2011, @entity6461 IRs increased 2.9%/year, @entity420 IRs declined nonsignificantly, and @entity2735 IRs increased 14.2%/year. @entity6461 and @entity420 IR patterns and trends were similar across anal and @entity5 . CONCLUSIONS: Rates of anal @entity6461 and @entity2735 have increased strongly over time, in contrast to rates of anal @entity420 , similar to trends observed for rectal @entity6461 and @entity420 . IMPACT: Anal @entity6461 and @entity420 likely have different etiologies, but may have similar etiologies to rectal @entity6461 and @entity420 , respectively. Strong increases in @entity2735 IRs over time may reflect @entity5 screening patterns. Cancer Epidemiol Biomarkers Prev; 24(10); 1-9.   2015 AACR.
