Morphometric evaluation of post- XXXX capillary perfusion in selectively vulnerable areas of gerbil brain.

@entity1400 @entity63 @entity1399
In gerbils the hemispheric blood flow was interrupted for 5 min by bilateral carotid artery occlusion to produce delayed selective destruction of the @entity1399 sector of hippocampus. The influence of hemodynamic factors was studied by evaluating the microcirculation before and at two times after @entity63 (3 min and 7 days), using Evans blue as an intravital vascular tracer. The density of perfused capillaries and the fractional volume of circulating blood were determined by quantitative morphometry and the values for the vulnerable @entity1399 sector compared with those for the resistant @entity1400 sector and cerebral cortex. In control animals the number of perfused capillaries in the @entity1399 sector was about 20% lower, and the volume of circulating blood about 30% lower, than in the @entity1400 sector or cerebral cortex. This difference was markedly enhanced after 5-min @entity63 . During the early recirculation phase, capillary perfusion improved in the cortex, whereas in the @entity1399 sector (and to a lesser degree also in the @entity1400 sector) it declined. After 7 days, the density of perfused capillaries and the volume of circulating blood had returned to control levels in the cerebral cortex and @entity1400 sector of hippocampus. In the @entity1399 sector, in contrast, the microcirculation had further deteriorated. The density of perfused capillaries was less than 30%, and the circulating blood volume even less than 50%, of that in the cerebral cortex.(ABSTRACT TRUNCATED AT 250 WORDS)
