Large bowel XXXX and carcinoma in @entity31 .

@entity154 @entity5 @entity6349 @entity31 @entity5932 @entity33 @entity3909 @entity694 @entity3137 @entity1141
The clinicopathological details of eight cases of @entity31 complicated by @entity694 are described. There was a total of 14 primary @entity694 , six of which were not detected before pathological examination of the resection specimens. The reason for this may be related to atypical @entity5 growth patterns. Three occurred in flat mucosa, one in a @entity3137 , and another in @entity5932 . The occurrence, distribution, and morphology of @entity33 were noted in both resection specimens and biopsies taken at varying stages before resection. @entity5 was associated with normal and adjacent @entity6349 mucosa of varying grades. The extent and grade of @entity1141 were not reliable indicators of @entity5 differentiation or subsequent clinical outcome. Only two @entity5 were poorly differentiated. In five cases a total of 23 mucosal biopsies were taken, all less than 12 months before resection. Three rectal biopsies were graded positive for @entity1141 and three colonic biopsies indefinite for @entity1141 . The subsequent resection specimens showed both @entity3909 changes. Three rectal and 14 colonic biopsies were graded negative for @entity1141 despite positive findings in the subsequent resection specimens. This @entity154 is partly attributed to the patchy nature of @entity1141 in colitic mucosa. Two cases illustrate the possibility of @entity1141 pursuing a rapidly progressive course. The mucosal changes of @entity31 were assessed using a recently introduced and standardised international classification.
