Fate of the catecholamine stores in the XXXX carotid body superfused in vitro.

@entity4925 @entity935 @entity26 @entity95 @entity460 @entity669 @entity1063 @entity4095
In @entity95 carotid bodies (CBs) superfused during 1-5 h, with an air-equilibrated medium containing no @entity669 (TYR), the @entity935 (DA) content decreased by approximately 60% after 1 h and remained constant afterwards. TYR and @entity4925 ( @entity4925 ) decreased with the same time course. @entity1063 (NA) content exhibited a biphasic decrease of lesser magnitude than that of DA. Superfusions with a TYR-containing medium did not prevent the reduction in DA and TYR. Large amounts of DA and @entity4925 were recovered in the effluent during the first hour of superfusion but after 90 min the two substances had declined below the detection limits (i.e. 0.5 and 1 pmol/5 min, respectively). The DA efflux decreased exponentially during the first hour and was not altered by changing the @entity26 partial pressure ( @entity4095 ) of the medium. The @entity4925 efflux declined after 40 min of superfusion and was modulated by @entity4095 . The DA and the @entity4925 effluxes were not suppressed by omitting @entity460 ions from the superfusing medium. In 4 cat CBs equal amounts of DA and NA were recovered from the effluent during the first hour of superfusion.
