Maternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female XXXX offspring.

@entity1 @entity2194 @entity35
UNASSIGNED: Large numbers of @entity1 are unknowingly exposed to @entity2194 ( @entity2194 ) from wireless devices. Evidence exists for altered cerebellar development in association with prenatal exposure to @entity2194 . However, insufficient information is still available regarding the effects of exposure to 900 megahertz (MHz) @entity2194 during the prenatal period on subsequent postnatal cerebellar development. This study was planned to investigate the 32-day-old female @entity35 pup cerebellum following exposure to 900MHz @entity2194 during the prenatal period using stereological and histopathological evaluation methods. Pregnant @entity35 were divided into control, sham and @entity2194 groups. Pregnant @entity2194 group (PEMFG) @entity35 were exposed to 900MHz @entity2194 for 1h inside an @entity2194 cage during days 13-21 of pregnancy. Pregnant sham group (PSG) @entity35 were also placed inside the @entity2194 cage during days 13-21 of pregnancy for 1h, but were not exposed to any @entity2194 . No procedure was performed on the pregnant control group (PCG) @entity35 . Newborn control group (CG) @entity35 were obtained from the PCG mothers, newborn sham group (SG) @entity35 from the PSG and newborn @entity2194 group (EMFG) @entity35 from the PEMFG @entity35 . The cerebellums of the newborn female @entity35 were extracted on postnatal day 32. The number of Purkinje cells was estimated stereologically, and histopathological evaluations were also performed on cerebellar sections. Total Purkinje cell numbers calculated using stereological analysis were significantly lower in EMFG compared to CG (p<0.05) and SG (p<0.05). Additionally, some pathological changes such as pyknotic neurons with dark cytoplasm were observed in EMFG sections under light microscopy. In conclusion, our study results show that prenatal exposure to @entity2194 affects the development of Purkinje cells in the female @entity35 cerebellum and that the consequences of this pathological effect persist after the postnatal period.
