Effect of XXXX or Salpingectomy for Ectopic Pregnancy on Subsequent In Vitro Fertilization-Embryo Transfer Outcomes.

@entity1 @entity6822 @entity4207 @entity5849 @entity52 @entity1499
OBJECTIVE: To investigate the effect of @entity1499 ( @entity6822 ) or salpingectomy for ectopic pregnancy on the outcomes of subsequent @entity52 ( @entity52 )-embryo transfer (ET) cycles. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-3). SETTING: @entity4207 center. @entity1 : All @entity1 undergoing fresh @entity52 -ET between January 2004 and July 2013 after treatment of an ectopic pregnancy with @entity6822 or salpingectomy in the preceding @entity52 -ET cycle were analyzed for potential inclusion. INTERVENTION: @entity6822 or laparoscopic salpingectomy for an ectopic pregnancy followed by a subsequent @entity52 -ET cycle. MEASUREMENTS AND MAIN RESULTS: A total of 144 @entity1 with sonographically confirmed @entity5849 were identified during the study period. Of these, 107 (74.3%) @entity1 were treated with @entity6822 and 37 (25.7%) were treated with laparoscopic salpingectomy. Eighty-eight @entity1 (82.2%) in the @entity6822 group and 22 @entity1 (59.4%) @entity1 in the salpingectomy group underwent a subsequent @entity52 -ET cycle. There were no significant differences in demographic data or baseline cycle characteristics between the 2 groups. No difference was observed in basal follicle-stimulating hormone (FSH) level before and after @entity6822 or salpingectomy treatment. Indicators of ovarian responsiveness, including total days of stimulation, total dosage of gonadotropins, and number of mature oocytes before and after either treatment, were comparable in the 2 groups. The number of doses of @entity6822 (1 vs > 1) did not correlate with changes in ovarian response. The pregnancy outcomes, specifically live birth, were equivalent in the 2 groups. Comparing post- @entity6822 cycles and post-salpingectomy cycles, @entity1 in the latter group required higher doses of gonadotropins (+705 IU vs +221.5 IU; p < .01), although the number of mature oocytes remained similar in the 2 groups. CONCLUSION: Treatment of @entity5849 with @entity6822 or salpingectomy might not adversely affect ovarian reserve, ovarian responsiveness, or subsequent @entity52 cycle outcomes. However, in our study cohort, @entity1 treated with @entity6822 , those s treated with laparoscopic salpingectomy required higher gonadotropin doses in a subsequent cycle to attain the same number of mature oocytes.
