Kinase regulation by @entity599 and XXXX containing compounds.

@entity1 @entity32 @entity10610 @entity0 @entity6 @entity5 @entity4259 @entity8189 @entity584 @entity10609 @entity4675 @entity599
Kinases are enzymes that are involved in a wide-range of cellular targets such as cell proliferation, metabolism, survival and apoptosis. Aberrations in the activity of the kinases have been linked to many @entity1 diseases such as @entity6 , @entity32 and @entity5 . The discovery of more than 518 kinases encoded by the @entity1 genome has spurred the development of rapid screening techniques for potential drugs against these enzymes and these have been identified as interesting targets for medicinal chemistry programs, especially in @entity5 therapy. On the other hand, @entity599 and @entity4259 have been increasingly recognized as essential elements in biology and medicine. Converging data from epidemiological and clinical studies have highlighted these elements as effective chemopreventive agents, particularly against various types of @entity5 (prostate, lung, @entity0 , colon, skin, lymphome, thyroid, pancreas, liver). These elements act through a wide range of potential mechanisms where one identified signal pathway event is kinase modulation, which is common for the two elements and emerges as a valid target. The kinases modulated by @entity599 and @entity4259 derivatives include MAP, ERK, @entity4675 , @entity584 , @entity10610 , @entity8189 and @entity10609 amongst others. Although both of the elements in question are in the same group in the periodic table and have similar biochemistries, there are relevant differences related to redox potentials, stabilities, oxidation states and anticancer activity. Literature data suggest that the replacement of @entity599 by @entity4259 in established @entity5 chemopreventive agents results in more effective chemopreventive analogs. In view of the multi-target kinase mechanisms in preventing cellular transformation, as well as the differences and similarities between them, in this review we focus on the development of new structures that contain @entity4259 and/or @entity599 and discuss our understanding of the regulation of antitumoral effects with emphasis on kinase modulation activity and its implications in @entity5 .
