Slight improvement in mood and XXXX after antiepileptic drug withdrawal: a controlled study in @entity1 on monotherapy.

@entity1 @entity410 @entity308 @entity146 @entity1316 @entity2049 @entity302 @entity734
OBJECTIVE: Most @entity734 ( @entity734 ) are considered to have effects on mood and to be effective in a number of @entity1316 . There are, however, conflicting reports in the literature with respect to the psychotropic properties of @entity734 . Many of the studies have a number of methodological problems, and much uncertainty still exists regarding the behavioral and mood effects of @entity734 . The aim of this study was to assess, in a randomized, double-blind, placebo-controlled study of @entity410 -free @entity1 with @entity302 , the effect of withdrawal of @entity734 in @entity1 on monotherapy on measures of mood and behavior. METHODS: One hundred fifteen subjects who had been @entity410 -free >2 years on drug monotherapy went through a randomized, double-blind, placebo-controlled study. Each @entity1 was included for 12 months or until @entity410 relapse. Behavioral function was assessed with the Minnesota Multiphasic Personality Inventory 2 (MMPI-2) at baseline and 7 months after withdrawal. RESULTS: Discontinuation of @entity734 resulted, to a greater extent than continued treatment, in a slight improvement in symptoms of @entity308 and @entity146 . Comparable results were achieved in the subgroup taking @entity2049 . For @entity1 with a high degree of @entity308 and somatic symptoms at baseline, no significant differences in symptoms emerged in the withdrawal group compared with the non-withdrawal group. CONCLUSION: The results suggest that @entity410 -free @entity1 with @entity302 on monotherapy can obtain a slight improvement in symptoms characteristic of @entity308 and @entity146 if they discontinue treatment with @entity734 . The described changes are limited, and the functional impact is of uncertain significance.
