@entity272 with IgE hyperproduction and pruritus in KFRS4/Kyo XXXX .

@entity1 @entity483 @entity5935 @entity272 @entity35 @entity1909
BACKGROUND: @entity35 showing spontaneous @entity483 ( @entity483 )-like @entity272 were observed in the Kyoto Fancy @entity35 Stock 4 (KFRS4) strain breeding colony. OBJECTIVE: To establish the KFRS4 @entity35 as a model of @entity483 . METHODS: The clinical symptoms of @entity483 -like @entity272 were assessed by scoring the degree of @entity1909 and examining scratching behavior. The transepidermal water loss was measured to evaluate skin barrier function. Cells infiltrating the @entity272 were identified using histological and immunohistological analyses. IgE and cytokine levels were measured to examine immune status. An ointment treatment experiment was carried out to characterize @entity1909 in the KFRS4 @entity35 . RESULTS: @entity1909 initially appeared around 4 months of age and rapidly worsened from 6 to 8 months of age. The @entity272 accompanied scratching behavior and were predominantly observed in females. The increased transepidermal water loss indicated @entity272 . Extensive infiltration of eosinophils, mast cells and lymphocytes was observed in the @entity272 . The plasma IgE level increased in accord with increasing severity of @entity1909 . The Th2 and Th17 cytokine mRNA levels were significantly higher in the skin-draining lymph nodes than those in the non-skin-draining lymph nodes. It was demonstrated that @entity5935 improved the symptoms of @entity1909 . These findings demonstrated that @entity1909 in the KFRS4 @entity35 closely resembled that seen in @entity1 @entity483 . CONCLUSION: Female KFRS4 @entity35 have the potential to serve as an animal model of @entity1 @entity483 .
