Antineutrophil cytoplasmic antibodies in XXXX --potential for misdiagnosis?

@entity1 @entity625 @entity1333 @entity2883 @entity7134 @entity309
Antineutrophil cytoplasmic antibodies (ANCA) are well described in @entity2883 and some forms of @entity1333 . They have also been described in @entity1 with @entity625 , but the specificity of these ANCA and their relationship to the presence of @entity1333 , antinuclear antibodies (ANA) and granulocyte-specific ANA (GS-ANA), and to disease activity are uncertain. We studied 101 @entity1 with forms of @entity625 and detected four cytoplasmic ANCA, eight perinuclear ANCA and 16 atypical ANCA. There was no association between the presence of ANCA and ANA or rheumatoid factor. No anti- @entity7134 antibodies were found and no strong anti-myeloperoxidase antibodies were detected. Four GS-ANA were detected and were distinct from ANCA. There was no association between @entity309 and ANCA status. ANCA did not predict @entity1333 over a 3 yr follow-up. These ANCA appear to be epiphenomena. Their importance lies in their potential to mislead physicians towards a misdiagnosis of @entity1333 .
