Mesenteric lymph duct ligation prevents shock-induced XXXX and shape changes.

@entity548 @entity16 @entity881 @entity35 @entity85 @entity8682 @entity130
OBJECTIVES: The exact mechanisms that lead to @entity85 and shape changes after @entity130 / @entity548 remain unknown. We hypothesize that @entity130 is caused in part by gut injury and is mediated by gut-derived factors carried in the intestinal lymph. MATERIALS AND METHODS: @entity85 was measured by a laser-assisted ektacytometer before and after @entity130 / @entity548 (T/ @entity8682 ) in 6 @entity35 whose mesenteric lymph duct had been ligated and in 10 @entity35 subjected to T/ @entity8682 without duct ligation. In this assay a decrease in the elongation index is a marker of @entity85 . RBC shape was examined by scanning electron microscopy. RESULTS: In the T/ @entity8682 @entity35 , the RBC elongation index decreased after T/ @entity8682 from a preshock value of 0.064 +/- 0.011 to 0.052 +/- 0.009 (P < 0.01) and remained low (0.049 +/- 0.010) even at 3 h after resuscitation. In contrast, the elongation index did not decrease after T/ @entity8682 in the lymph duct-ligated @entity35 (0.062 +/- 0.004 vs. 0.056 +/- 0.005, P = NS). Likewise, the T/ @entity8682 @entity35 , but not the duct-ligated T/ @entity8682 @entity35 , had a significant increase in the percentage of abnormally shaped RBCs when studied by electron microscopy. CONCLUSIONS: Interruption of lymph flow from the gut into the bloodstream by lymph duct ligation prevents T/ @entity8682 -induced @entity16 . Because @entity85 contributes to impaired perfusion of the microcirculation, preservation of @entity85 may decrease the incidence of T/ @entity8682 -induced @entity881 .
