The rovA mutant of XXXX displays differential degrees of virulence depending on the route of @entity281 .

@entity32 @entity19 @entity262 @entity281 @entity2820
@entity2820 is an invasive enteric pathogen that causes significant @entity32 . Recently, we identified and characterized a global regulator of virulence (rovA). When @entity19 are infected orally with the rovA mutant they are attenuated by 50% lethal dose (LD(50)) analysis and have altered kinetics of @entity281 . Most significantly, @entity19 orally infected with the rovA mutant have greatly reduced @entity32 in the Peyer's patches compared to those infected with wild-type @entity2820 . However, we present data here indicating that when the rovA mutant bacteria are delivered intraperitoneally (i.p.), they are significantly more virulent than when delivered orally. The i.p. LD(50) for the rovA mutant is only 10-fold higher than that of the wild-type @entity2820 , and there are significant @entity32 responses to the rovA mutant that are evident in the liver and spleen. Altogether, these data suggest that the RovA regulon may be required for the early events of the @entity281 that occur in the Peyer's patches. Furthermore, these data suggest that the RovA regulon may be dispensable for @entity2820 @entity262 and @entity32 responses if the Peyer's patches are bypassed.
