XXXX : proctocolectomy and mucosectomy do not necessarily eliminate pouch-related @entity5 incidences.

@entity1 @entity4256 @entity10664 @entity5 @entity5042 @entity31 @entity189 @entity29 @entity14 @entity1162 @entity255 @entity1141
BACKGROUND: @entity14 ( @entity14 ), the most lethal long-term complication of @entity29 ( @entity29 ), is the culmination of a complex sequence of molecular and histologic derangements of the colon epithelium that are initiated and at least partially sustained by @entity1162 . @entity1141 , the earliest histologic manifestation of this process, plays an important role in @entity5 prevention by providing the first clinical alert that this sequence is under way and by serving as an endpoint in colonoscopic surveillance of @entity1 at high risk for @entity14 . @entity4256 ( @entity4256 ) is indicated for @entity1 with @entity29 , specifically for @entity31 that is refractory to medical treatment, emergency conditions, and/or in case of @entity5 . Even after @entity4256 with mucosectomy, pouch-related @entity189 have recently been reported with increasing frequency since the first report in 1984. We review @entity29 -associated @entity14 and pouch-related @entity5 prevalence, adverse events, risk factors, and surveillances. METHODS: Literature of @entity29 -associated @entity14 @entity1 and those undergoing @entity4256 surgeries through 2010 were prospectively reviewed. RESULTS: We found 12 studies from retrospective series and 15 case reports. To date, there are 43 reported cases of pouch-related @entity5 . Thirty-two @entity1 had @entity5 in the anal transit zone ( @entity10664 ); of these, 28 @entity1 had mucosectomy. Eleven @entity1 had @entity5 found in the pouch body. CONCLUSION: @entity4256 with mucosectomy does not necessarily eliminate risks. There is little evidence to support routine surveillance of pouch mucosa and the ATZ except for @entity1 associated with histological type C changes, sclerosing @entity255 , and unremitting @entity5042 .
