Effects of central @entity935 depletion on the XXXX discriminative stimulus in @entity35 .

@entity2254 @entity5829 @entity935 @entity3826 @entity2072 @entity9956 @entity750 @entity35 @entity1063 @entity2955
The discriminative stimulus properties of @entity2254 , @entity2072 , and @entity3826 were assessed in @entity35 trained in a two-lever, food-reinforced drug discrimination paradigm to discriminate 1.0 mg/kg @entity2254 from saline. After determination of these dose-response relationships, the @entity35 were divided into two groups. One group ( @entity2955 ) was given injections of @entity5829 ( @entity9956 , 30 mg/kg, IP) and @entity2955 ( @entity2955 , 100 micrograms/10 microliters each ventricle), while the other group (sham) was given the same dose of @entity9956 and @entity2955 vehicle (intraventricularly). Beginning approximately 45 days after intraventricular injections, dose-response relationships were redetermined for all three drugs. Larger doses of @entity2254 were required to elicit the same response in the @entity2955 group (i.e. the dose-response relationship was shifted to the right), while no change was observed in the sham group. Any changes in the dose-response relationships for @entity2072 and @entity3826 were comparable in the @entity2955 and sham group. The rate-decreasing effects were not altered in either group for any of the drugs. Upon sacrifice, @entity935 (DA) was found to be significantly depleted in the accumbens, caudate and rest of brain of the @entity2955 group. Levels of @entity1063 and @entity750 were unaltered. These data suggest that central DA-containing neurons play a role in the discriminative stimulus properties of psychomotor stimulants in @entity35 .
