Pressor effect of electroacupuncture on XXXX .

@entity64 @entity9598 @entity2806 @entity235 @entity548 @entity3369 @entity1211 @entity2661 @entity551
Neiguan (PC-6) is a traditional acupoint in each forearm and overlies the trunk of the median nerve. Previous studies show that electroacupuncture (EA) at the Neiguan acupoint could improve not only myocardial @entity2806 by inducing a @entity9598 response but also recover @entity551 by inducing a pressor response. However, their physiological mechanisms are not yet elucidated. We investigated the pressor effect of Neiguan EA and its mechanism by focusing on left ventricular (LV) performance in a @entity235 @entity551 model. We hemorrhaged 36 anesthetized and thoracotomized mongrel @entity235 and decreased LV end-systolic pressure (ESP) to approximately 70 mmHg (35% decrease). We obtained LV pressure-volume (P-V) data with a micromanometer catheter and a conductance catheter. One-hour Neiguan EA significantly recovered the decreased ESP, end-diastolic volume, and @entity64 volume by 32 +/- 13%, 27 +/- 13%, and 39 +/- 17%, respectively (P < 0.05), without changing heart rate and the slope of the end-systolic P-V relation. Neiguan EA inhibited a @entity548 -induced increase in plasma @entity2661 . However, @entity3369 (neuromuscular blocking agent) administration abolished the antihypotension effect of Neiguan EA. Furthermore, Neiguan EA was much more effective than a nonacupoint thigh EA. We conclude that Neiguan EA achieved the antihypotension effect by improving LV filling of the @entity548 -depressed LV performance despite the inhibition of the @entity548 -increased plasma @entity2661 . This pressor effect seemed to accompany an @entity1211 by Neiguan EA-increased vasomotor tone and muscle pump. This study demonstrated a scientific basis for the therapeutic efficacy of acupuncture in the treatment of @entity551 and shock.
