Radiation Therapy for Para-Aortic Lymph Node @entity3 from Uterine Cervical XXXX .

@entity1 @entity137 @entity5 @entity1161 @entity957 @entity1960 @entity3 @entity2335
AIM: To evaluate the efficacy of radiation therapy for para-aortic lymph node @entity3 from @entity5 and to identify an optimal radiation regimen. @entity1 AND METHODS: A total of 80 metastatic para-aortic lymph nodes, ranging from 11-50 mm (median=20 mm) on computed tomography, in 22 @entity1 with @entity957 were initially treated with radiation therapy. Total radiation doses for para-aortic lymph node @entity3 were 40-61.2 Gy (median=50.4 Gy) in 1.8-2 Gy fractions. RESULTS: Eight out of the 22 @entity1 remained alive at a median follow-up of 32 months. Seven irradiated lymph nodes, 20-50 mm in diameter, in four @entity1 progressed after irradiation at total doses of 44-50.4 Gy. No metastatic lymph nodes administered >50.4 Gy (median=55.8 Gy) exhibited progression after irradiation. All metastatic lymph nodes  <=25 mm in diameter irradiated with 50 or 50.4 Gy were controlled. The 3-year lymph node progression-free rates were 78% in the cohort of 22 @entity1 and 89% considering all 80 metastatic lymph nodes. Apart from transient hematological reactions, two @entity1 developed grade 3 or more therapy-related @entity137 , including @entity1161 in one and @entity2335 and @entity1960 in another. CONCLUSION: Radiation therapy can effectively control para-aortic lymph node @entity3 in @entity1 with @entity5 . A total dose of 50.4 Gy in 1.8 Gy fractions is sufficient to control metastatic lymph nodes  <=25 mm in diameter, whereas a higher dose (approximately 55.8 Gy) may be required for larger nodes.
