Potential of dietary XXXX in angiogenesis.

@entity63 @entity2772 @entity26 @entity409 @entity3542 @entity1507 @entity519 @entity842 @entity453 @entity731 @entity65
@entity409 with impaired bioavailability of @entity842 (NO) is the hallmark in the development of @entity65 . @entity409 leads to @entity731 , characterized by chronic inflammation of the arterial wall and stepwise narrowing of the vessel lumen. @entity731 causes deprivation of adequate tissue blood flow with compromised @entity26 supply. To overcome this undersupply, remodeling of the vascular network is necessary to reconstitute and sustain tissue viability. This physiological response is often not sufficient and therapeutic angiogenesis remains an unmet medical need in @entity63 or @entity453 . Feasible approaches to promote blood vessel formation are sparse. Administration of pro-angiogenic factors, gene therapy, or targeting of microRNAs has not yet entered the daily practice. @entity842 is an important mediator of angiogenesis that becomes limited under @entity63 conditions and the maintenance of NO availability might constitute an attractive therapeutic target. Until recently it was unknown how the organism provides NO under @entity63 . In recent years it could be demonstrated that NO can be formed independently of its enzymatic synthesis in the endothelium by reduction of inorganic @entity3542 under @entity519 conditions. Circulating @entity3542 derives from oxidation of NO or reduction of inorganic @entity1507 by commensal bacteria in the oral cavity. Intriguingly, @entity1507 is a common constituent of our everyday diet and particularly high concentrations are found in leafy green vegetables such as @entity2772 , lettuce, or beetroot. Evidence suggests that dietary @entity1507 supplementation increases the regenerative capacity of @entity63 tissue and that this effect may offer an attractive nutrition-based strategy to improve @entity63 -induced revascularization. We here summarize and discuss the regenerative capacity of dietary @entity1507 on the vascular system.
