Neoadjuvant chemotherapy with a combination of pegylated liposomal @entity632 (Caelyx) and XXXX in locally advanced @entity0 : a phase II study by the Hellenic Cooperative Oncology Group.

@entity632 @entity1 @entity137 @entity0 @entity1311 @entity1398 @entity1431 @entity204 @entity5515 @entity2359
BACKGROUND: To determine the activity and safety of the combination of @entity1311 and pegylated liposomal @entity632 (Caelyx) in @entity1 with locally advanced @entity0 . @entity1 AND METHODS: This was a multicenter phase II study. Thirty-five newly diagnosed @entity1 with locally advanced @entity0 were included in the study. Histological or cytological diagnosis was necessary for inclusion. Median age was 54 years (range 26-73 years). Fifteen @entity1 were premenopausal and 20 postmenopausal. @entity1311 was administered at a dose of 175 mg/m(2) and pegylated liposomal @entity632 35 mg/m(2) every 3 weeks for six cycles. RESULTS: Twenty-five @entity1 (71%) responded. Six (17%) had a complete response, 19 (54%) had a partial response, four remained stable, two progressed and four were not evaluated for response due to discontinuation of chemotherapy. Three @entity1 had a pathologically complete response. A total of 173 cycles were administered. The primary @entity137 observed was @entity137 . Grade 3 @entity137 was noted in four @entity1 (11%). @entity5515 ( @entity5515 ) grade 3 was experienced by three (9%). Two @entity1 presented with @entity5515 and @entity137 . Hematological @entity137 included grade 3 @entity1431 in four @entity1 (3%). Other grade 3 @entity137 were uncommon and included only alopecia in 29 @entity1 (83%). Grade 3 or 4 @entity2359 was not observed in any @entity1 . Dose reduction was necessary in seven @entity1 ; in six due to @entity137 and in one due to @entity1398 . Four @entity1 discontinued treatment due to @entity137 . There were no treatment-related @entity204 . CONCLUSIONS: The combination of pegylated liposomal @entity632 and @entity1311 was active in locally advanced @entity0 . The primary @entity137 was cutaneous @entity137 and it was manageable.
