High-Resolution Magnetic Resonance Imaging  Can Reliably Detect Orbital Tumor  Recurrence after Enucleation in  XXXX with @entity995 .

@entity1 @entity5 @entity2287 @entity3 @entity204 @entity995
PURPOSE: @entity5 recurrence is a rare but serious complication in @entity1 with @entity995 , leading to a high risk of @entity3 and @entity204 . Therefore, we assume that these recurrences have to be detected and treated as early as possible. Preliminary studies used magnetic resonance imaging (MRI) to evaluate postsurgical findings in the orbit. In this study, we assessed the diagnostic accuracy of high-resolution MRI to detect @entity5 recurrence in @entity1 with @entity995 in a large study cohort. DESIGN: Consecutive retrospective study (2007-2013) assessing MRI findings after enucleation. @entity1 : A total of 103 MRI examinations of 55 orbits (50 @entity1 , 27 male/23 female, mean age 16.3  12.4 months) with a median time of 8 months (range, 0-93) after enucleation for @entity995 . METHODS: High-resolution MRI using orbital surface coils was performed on 1.5 Tesla MRI systems to assess abnormal orbital findings. MAIN OUTCOME MEASURES: Five European experts in @entity995 imaging evaluated the MRI examinations regarding the presence of abnormal orbital @entity2287 enhancement and judged them as " @entity5 ," "suspicious of @entity5 ," "postsurgical condition/scar formation," or "without pathologic findings." The findings were correlated to histopathology (if available), MRI, and clinical follow-up. RESULTS: Abnormal orbital enhancement was a common finding after enucleation (100% in the first 3 months after enucleation, 64.3% >3 years after enucleation). All histopathologically confirmed @entity5 recurrences (3 of 55 orbits, 5.5%) were correctly judged as " @entity5 " in MRI. Two orbits from 2 @entity1 rated as "suspicious of @entity5 " received intravenous chemotherapy without histopathologic confirmation; further follow-up (67  and 47 months) revealed no sign of @entity5 recurrence. In 90.2%, no @entity5 was suspected on MRI, which was clinically confirmed during follow-up (median follow-up after enucleation, 45 months; range, 8-126). CONCLUSIONS: High-resolution MRI with orbital surface coils may reliably distinguish between common postsurgical contrast enhancement and @entity5 recurrence, and therefore may be a useful tool to evaluate @entity5 recurrence after enucleation in @entity1 with @entity995 . We recommend high-resolution MRI as a potential screening tool for the orbit in @entity1 with @entity995 to exclude @entity5 recurrence, especially in high-risk @entity1 within the critical first 2 years after enucleation.
