Preoperative and postoperative analgesic techniques in the treatment of XXXX undergoing transabdominal hysterectomy: a preliminary randomized trial.

@entity1 @entity650 @entity310 @entity1337 @entity3652 @entity18907 @entity158 @entity701 @entity413 @entity282 @entity3575 @entity8726
BACKGROUND: Although pre-emptive @entity1337 is commonly used for the management of @entity282 in developed countries, no defined protocol has been carried out and widely practiced, especially in transabdominal hysterectomy. Keeping this in mind the present study aimed to investigate the effects of multimodal pre-emptive @entity1337 on @entity158 management, stress response and inflammatory factors of @entity1 undergoing transabdominal hysterectomy to find an optimized way of pre-emptive @entity1337 . METHODS: One hundred @entity1 undergoing abdominal hysterectomy were randomly divided into four groups (Trial registration: ChiCTR-IPR-15005848). Group P1 was given intravenous @entity8726 and epidural @entity3575 + @entity3652 before surgery; Group P2 received intravenous @entity8726 before surgery and epidural @entity3575 + @entity3652 after surgery; Group P3 was given epidural @entity3575 + @entity3652 before surgery and intravenous @entity8726 after surgery; @entity1 in Group C received normal saline treatment. RESULTS: Compared with control group, the first time to request additional analgesics after surgery were significantly later (P < 0.05), 24 h dosage of @entity1337 were significantly less (P < 0.05), VAS score at all time periods after surgery were significantly lower (P < 0.05) in Group P1, P2, or P3. At 12 h or 24 h after surgery, VAS score in Group P1 was significantly lower than that in group @entity18907 (P < 0.05, P < 0.05). No significant adverse effects were found among the groups (P > 0.05). At 1 or 2 days after surgery, the levels of @entity701 , @entity413 , and @entity650 , @entity310 in group P1, P2, and P3 were significantly lower than those in group C (P < 0.05); while, the levels in group P2, P3 were significantly lower than those in group P1 (P < 0.05). CONCLUSION: Multimodal pre-emptive @entity1337 could significantly lower VAS score, inhibit stress response, and reduce inflammatory response in @entity1 undergoing transabdominal hysterectomy, which can be a rational strategy for @entity158 control in future. TRIAL REGISTRATION: ChiCTR-IPR-15005848 on January 17, 2015.
