XXXX enhances the activity of antimicrobial agents against pathogens of clinical relevance.

@entity796 @entity11150 @entity794 @entity11792 @entity3756 @entity54 @entity750 @entity3456 @entity526 @entity65543
BACKGROUND: @entity750 reuptake inhibitors were recently reported to possess antimicrobial potentials, potentiate activity of several antibiotics, reverse multidrug resistant phenotypes of bacteria and make them susceptible to previously resistant drugs. We investigated antimicrobial potentials of @entity3756 (SR) against ATCC strains, clinical isolates of @entity794 , @entity526 and @entity796 alone and in-combination with seven antibiotics. Antifungal activity was investigated against four fungal strains including @entity11150 , @entity54 , @entity11792 , and Fusarium solani. Intrinsic antibacterial action and Minimum Inhibitory Concentrations (MICs) were determined using well assay, nutrient broth and agar dilution techniques. Disk diffusion and nutrient broth methods were used to study bacterial susceptibility to SR. Minimum Fungicidal Concentrations (MFCs) of SR were determined using Sabouraud dextrose Agar (SDA). RESULTS: @entity3756 possesses strong intrinsic antibacterial, antifungal activities and has augmented the antibacterial activities of antibiotics. For @entity794 ATCC 6538, @entity65543 and @entity796 ATCC 9027, the MICs of SR were 20, 40 and 60   g  ml(-1), respectively, whereas 55.5% clinical isolates of @entity794 and 50% of @entity526 strains were inhibited at 20 and 60   g  ml(-1) of SR, respectively. Among the tested fungi, 60% of A. @entity3456 and A. fumigatus were inhibited at 40 and 80   g  ml(-1), respectively. MFCs were 60 and 80   g  ml(-1) for A. flavus and F. solani, respectively. Antibacterial activities of all antibiotics were significantly increased (p   <   0.001) with the addition of SR 100   g  ml(-1) against all tested bacteria. CONCLUSION: Combination study revealed that SR had significantly increased the activity of antibiotics, and some previously resistant strains were made susceptible. Thus antidepressants are potential sources of resistance modifying agents when used in combination.
