Hippocampal Malrotation Is Associated With XXXX : Results of the FEBSTAT Study.

@entity1 @entity131 @entity410 @entity600 @entity159
OBJECTIVE: @entity131 is characterized by incomplete hippocampal inversion with a rounded shape and blurred internal architecture. There is still debate about whether @entity131 has pathologic significance. We present findings from the Consequences of @entity410 in Childhood (FEBSTAT) study on the frequency of and risk factors for @entity131 . SUBJECTS AND METHODS: FEBSTAT is a prospective multicenter study investigating the consequences of @entity159 in childhood. MRI studies of 226 @entity1 with @entity159 were analyzed visually by two board-certified neuroradiologists blinded to clinical details and were compared with MRI studies of 96 subjects with first @entity410 . Quantitative analysis of hippocampal volume was performed by two independent observers. RESULTS: @entity131 was present in 20 of 226 (8.8%) @entity1 with @entity159 compared with two of 96 (2.1%) control subjects (odds ratio [OR], 4.56; 95% CI, 1.05-19.92). @entity131 was exclusively left-sided in 18 of 22 (81.8%) @entity1 and bilateral in the remaining four @entity1 (18.2%). There was no case of exclusively right-sided @entity131 . @entity131 was more common in @entity1 than in @entity1 (OR, 6.1; 95% CI, 1.7-21.5). On quantitative volumetric MRI analysis, the left hippocampal volume was smaller in @entity1 with @entity131 than in control subjects with @entity410 (p = 0.004), and the right-to-left hippocampal volume ratio was higher in the @entity131 group than in the @entity410 group (p < 0.001). CONCLUSION: @entity131 is a developmental @entity600 that predominantly affects the left hippocampus in male @entity1 and is more frequently found in @entity1 with prolonged @entity159 than in control subjects. These data provide further evidence that @entity131 represents a pathologic error in brain development rather than a normal variant.
