Effects of @entity230 on thrombogenic markers in XXXX undergoing unilateral total knee arthroplasty: A prospective, double-blind, randomized controlled trial.

@entity1 @entity32 @entity650 @entity701 @entity230 @entity1211
UNASSIGNED: @entity1211 ( @entity1211 ) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. @entity32 , characterized by a rise in @entity650 ( @entity650 ), initiates the coagulation cascade, but low-dose @entity230 can reduce post-TKA @entity650 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 @entity1 undergoing unilateral TKA to assess the effect of perioperative @entity230 on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study @entity1 received 100   mg of intravenous @entity701 2   h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4   h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4   h compared to controls (616        358   pMol/L vs. 936        332   pMol/L, p   =   0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672        173   pMol/L vs. 350        211   pMol/L, p   <   0.001). Mean PAP was higher in the study group at 4   h (1639        823     g/L vs. 1087        536     g/L), but did not reach statistical significance (p   =   0.07). These results may have clinical implications in terms of postoperative @entity1211 risk and management.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
