@entity632 -Loaded Alginate-g- XXXX Micelles for Cancer Imaging and Therapy.

@entity632 @entity1 @entity26408 @entity5 @entity19 @entity1683
Chemotherapy is a widely adopted method for the treatment of @entity5 . However, its use is often limited due to side effects produced by anti- @entity5 drugs. Therefore, various drug carriers, including polymeric micelles, have been investigated to find a method to overcome this limitation. In this study, alginate-based, self-assembled polymeric micelles were designed and prepared using alginate-g- @entity1683 ( @entity1683 ). Amino-PNIPAAm was chemically introduced to the alginate backbone via @entity26408 chemistry. The resulting polymer was dissolved in distilled water at room temperature and formed self-assembled micelles at 37   C. Characteristics of alginate-g- @entity1683 micelles were dependent on the molecular weight of @entity1683 , the degree of substitution, and the polymer concentration. @entity632 (DOX), a model anti- @entity5 drug, was efficiently encapsulated in alginate-g- @entity1683 micelles, and sustained release of DOX from the micelles was achieved at 37   C in vitro. These micelles accumulated at the @entity5 site of a @entity5 -bearing @entity19 model as a result of the enhanced permeability and retention effect. Interestingly, DOX-loaded alginate-g- @entity1683 micelles showed excellent anti- @entity5 therapeutic efficacy in a @entity19 model without any significant side effects. This approach to designing and tailoring natural polymer-based systems to fabricate nanoparticles at @entity1 body temperature may provide a useful means for @entity5 imaging and therapy.
