@entity37462 Polymorphism and its Relations to Bone Mineral Density in XXXX .

@entity1 @entity5066 @entity170 @entity37462 @entity71835 @entity1555 @entity2331
BACKGROUND AND AIMS: Recognition of different genetic variants underlying development of @entity170 would make it possible to administer individual symptomatic treatment as well as early prophylactics of @entity170 . The aim of the study was to evaluate frequency of polymorphism 326A/T of gene @entity37462 and assessment of its relations with the clinical parameters of osseous turnover and degree of @entity170 . METHODS: The study included 800 @entity1 at the postmenopausal (505) and reproductive (295) age throughout Wielkopolska region in Poland. The postmenopausal group included @entity1 with @entity170 and @entity2331 and the healthy ones. @entity1 at the reproductive age were healthy. Frequency of the tested gene polymorphism was evaluated in the group where @entity1555 was marked and in the control group. RESULTS: The analysis of the polymorphism @entity71835 of gene @entity37462 showed that in healthy postmenopausal female with genotype @entity5066 birth weight, @entity1555 L2-L4 YA (%) and @entity1555 L2-L4 AM (%) were significantly higher ( @entity1555 -bone mineral density; L2-L4-- lumbar vertebrae no 2, 4; YA--peak adult bone mass; AM--age-matched bone mass). In @entity1 with @entity1555 L2-L4 YA (%) and @entity1555 L2-L4 AM (%) were significantly higher in @entity1 with genotype @entity5066 , but @entity1555 L2-L4 was significantly higher in @entity1 with genotype TT. In @entity1 with @entity170 with genotype @entity5066 T-score was significantly higher, but @entity1555 L2-L4 and @entity1555 L2-L4 YA (%) were significantly lower in this group. @entity1555 L2-L4 AM (%) was significantly higher in @entity1 with @entity5066 genotype. CONCLUSION: In @entity1 with @entity170 and @entity2331 homozygous @entity5066 genotype may predispose to lower @entity1555 in the lumbar spine.
