Self-reported cognitive functioning in postmenopausal @entity0 XXXX before and during endocrine treatment: findings from the neuropsychological TEAM side-study.

@entity1 @entity308 @entity0 @entity440 @entity73 @entity1295 @entity17082 @entity148
OBJECTIVE: This study aimed to evaluate self-reported cognitive functioning of postmenopausal @entity0 @entity1 before and during endocrine treatment compared with healthy female controls, and to investigate associations between self-reported cognitive functioning, cognitive test performance and @entity148 / @entity308 , @entity1295 , and menopausal complaints. METHODS: Self-reported cognitive functioning, @entity148 / @entity308 , @entity1295 , menopausal complaints, and cognitive tests performance were assessed before (T1) and after 1 year (T2) of adjuvant endocrine treatment in postmenopausal chemotherapy-na  ve @entity0 @entity1 . Self-reported cognitive functioning was assessed by the @entity73 questionnaire and interview questions concerning cognitive complaints. @entity1 participated in the TEAM-trial, a prospective randomized study investigating @entity440 versus @entity17082 as adjuvant therapy for hormone-sensitive @entity0 . Identical information was obtained from healthy postmenopausal volunteers. RESULTS: Two measures for self-reported cognitive functioning provided the distinctive results. At T1 and T2, healthy controls reported a higher frequency of @entity73 than @entity1 ; change over time did not differ between groups. The prevalence of cognitive complaints did not differ between the groups at T1, but change over time regarding attention/concentration complaints differed between groups, due to an increased prevalence in @entity440 users. Self-reported cognitive functioning showed moderate associations with @entity148 / @entity308 , @entity1295 , and menopausal complaints. Cognitive test performance was not associated with self-reported cognitive functioning, but weakly with @entity148 / @entity308 and @entity1295 . CONCLUSION: Adjuvant therapy with @entity440 and @entity17082 did not influence the self-reported frequency of @entity73 . Increased attention/concentration complaints were observed in @entity440 users, but not in @entity17082 users. This latter finding should be confirmed with better validated instruments.
