Prenatal exposure to maternal psychosocial @entity1642 and XXXX regulation in young adults.

@entity1 @entity6100 @entity2339 @entity701 @entity1642
Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the @entity2339 in response to prenatal @entity1642 has been proposed as one underlying mechanism. The present study investigated in @entity1 the association of prenatal psychosocial @entity1642 exposure with subsequent @entity2339 regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe @entity1642 during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal @entity1642 (PS) group, n=31) and an age-matched comparison group (CG, n=30) underwent the @entity6100 ( @entity6100 ) and a 1 microg ACTH(1-24) stimulation test. In addition, a diurnal @entity701 profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm ( @entity6100 ) were marginally significantly higher in PS subjects than in CG subjects (p=.06). Pre- @entity6100 adrenocortical ( @entity701 ) levels were lower (p=.007), whereas the increase in @entity701 in response to the @entity6100 was higher (p=.03) in PS subjects compared to CG subjects. @entity701 concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH(1-24) test) were significantly lower in PS than in CG subjects (p=.006). No differences emerged between the two groups in basal diurnal @entity701 levels. This study provides first evidence in @entity1 of an association between prenatal psychosocial @entity1642 exposure and subsequent alterations in the regulation of the @entity2339 .
