Plasma levels of amyloid beta and other proinflammatory mediators in XXXX with age-related macular degeneration.

@entity1 @entity10691 @entity471 @entity13785
PURPOSE: To investigate the plasma levels of amyloid beta (Ab) and select inflammatory mediators in @entity1 with various stages of @entity13785 compared to that of age-matched controls, and discern a relationship to disease severity. METHODS: Plasma samples were obtained from @entity13785 subjects at various stages of disease-early (drusen only), @entity10691 ( @entity10691 ), @entity13785 ( @entity471 )-and from controls of similar age without @entity13785 . Samples were analyzed using a commercially available ELISA kit (sixteen cytokines) or LC/MS/MS (Ab isotypes). Descriptive statistics were compiled on all analytes. Analysis of covariance (ANCOVA) was conducted to compare each analyte across @entity13785 groups while adjusting for sex and age of the @entity1 , and in comparison to the control group. Receiver operating characteristics plots were generated for the strongest predictor variables. RESULTS: Levels of alternative spliced CC3 proteins were significantly different between controls and @entity471 groups (p   <   0.05), with median levels almost twice higher in @entity471 than in controls. There was an increasing trend for plasma levels of  -b isotypes across @entity13785 progressive stages (p values ranged from 0.052 to 0.0012) (ANCOVA). When adjusted for multiple comparisons analysis, plasma Ab 1-42 levels, and its ratio with Ab 1-40 were the most significantly associated with late @entity13785 stages. Consistently with the ANCOVA results for  -b isotypes, the ROC curve showed a moderate prediction (AUC   =   -   ~   0.78) of @entity13785 vs control using the Ab 1-42 isotype. CONCLUSION: Plasma Ab 1-42 may have utility as a systemic biomarker for @entity13785 .
