Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated XXXX .

@entity1 @entity32 @entity7940 @entity625 @entity1753 @entity35 @entity792 @entity309
UNASSIGNED: The objective of this study was to determine the expression and effects of B-lymphocyte stimulator (BLyS) in T cell-mediated @entity625 , a @entity35 model of @entity1 @entity309 ( @entity309 ). @entity35 @entity1753 ( @entity1753 ) was induced by intradermal injection of 0.1ml complete Freund's adjuvant. @entity625 was evaluated by the histopathological examination of joint ankle. The BLyS expression was detected by immunohistochemical analysis. The level of BLyS and @entity7940 were assayed by enzyme-linked immunosorbent assay. The gene expression of BLyS and its receptors (TACI, BCMA and BAFF-R) were assessed by quantitative reverse-transcription polymerase chain reaction. The effect of BLyS on the function of T cell was investigated by transwell assay. Using an @entity1753 @entity35 model, we detected dysregulated expression and level of BLyS and its receptors in the local joint synovium tissue, peripheral lymphoid organs (spleen) and immune cells (macrophage, dendritic cells (DC) and T cell) at the peak of @entity32 . In vitro, BLyS-treated DC induced @entity7940 producing T cells. Neutralization of BLyS by the TACI-Ig fusion protein attenuated these stimulating effects of BLyS. These data suggest that the overproduction of BLyS may contribute to T cell responses and may be an attractive target for control of @entity792 , such as @entity309 , that involves both T and B cells.
