Neonatal XXXX status and neurodevelopmental outcome at 9years.

@entity1 @entity844 @entity4600 @entity1426 @entity1474 @entity51 @entity4601
BACKGROUND: Long-chain @entity1474 (LCPUFA) are important for prenatal brain development. Previous studies of others assessed outcome until 7years. The associations between neonatal LCPUFA status and long-term developmental outcome are debated. AIM: To investigate the relationship between @entity844 status at birth and neurodevelopment at 9years. Age 9 is a unique age after a significant neurodevelopmental transition. STUDY DESIGN: Correlation study. Multivariable analyses were carried out to adjust for potential confounders. SUBJECTS: 317 @entity1 who participated in a trial on effects of postnatal LCPUFA supplementation were eligible. 235 @entity1 (74%) were reassessed at age 9. OUTCOME MEASURES: At birth, @entity4600 ( @entity4601 ) and @entity1426 (AA) were determined in the wall of the umbilical vein. We primarily studied the correlation between @entity4601 and AA with the complex form of minor @entity51 (cMND). Secondary correlations that were studied were @entity4601 and AA levels with cognitive development in terms of full IQ, and with behavioural development in terms of a total problem score. RESULTS: @entity1 with cMND showed lower @entity4601 values in the umbilical vein than @entity1 with better neurological condition (p=0.033). A similar association was absent in @entity1 . Neonatal AA values were not associated with neurological outcome. Neither neonatal @entity4601 nor AA values were associated with cognition and behaviour at 9. CONCLUSIONS: Higher umbilical @entity4601 levels in @entity1 are associated with better neurological development at 9years. AA status at birth was not associated with neurodevelopment at 9years.
