@entity36233 -dependent function of XXXX is involved in the hepatoprotective effects of betaine on adolescent @entity19 .

@entity1 @entity50593 @entity28 @entity28985 @entity19 @entity409 @entity36233 @entity5498 @entity1561 @entity7727 @entity65068 @entity33726
UNASSIGNED: @entity1561 ( @entity1561 ) is now the most common cause of chronic @entity409 among @entity1 and adolescents in the developed world. @entity7727 , as a @entity5498 donor, recently has been demonstrated to exert its hepatoprotective effects through rectifying the genomic DNA hypomethylation state. However, whether betaine supplementation affects @entity33726 (m(6)A) mRNA methylation in @entity1561 is still unknown. We conducted the current study to investigate the effects of betaine supplementation during adolescence on high-fat diet-induced pathological changes in liver of @entity19 , and we further identified the effects of betaine supplementation on expression of the fat mass and @entity28 -associated gene ( @entity36233 ) and hepatic m(6)A mRNA methylation. Our results showed that betaine supplementation across adolescence significantly alleviated high-fat-induced @entity409 and morphology as well as ectopic fat accumulation. Surprisingly, no significant effects on serum TG and NEFA level, as well as fat mass, were observed in @entity19 supplemented with betaine. We also found that high-fat diet upregulated @entity50593 and FAS gene expression and downregulated @entity28985 and @entity65068 gene expression. However, these alterations were rectified by betaine supplementation. Moreover, an m(6)A hypomethylation state and increased @entity36233 expression were detected in @entity19 fed with high-fat diet, while betaine supplementation prevented these changes. Our results suggested that betaine supplementation during adolescence could protect @entity19 from high-fat-induced @entity1561 by decreasing de novo lipogenesis and increasing lipolysis. Furthermore, a novel @entity36233 -dependent function of m(6)A may involve in the hepatoprotective effects of betaine.
