Interleukin-6 suppression reduces @entity5 self-seeding by circulating @entity5 cells in a human XXXX nude @entity19 model.

@entity5 @entity19 @entity10433 @entity777 @entity421 @entity3 @entity8837
Tumour self-seeding by circulating @entity5 cells (CTCs) enhances @entity5 progression and recurrence. Previously, we demonstrated that @entity5 self-seeding by CTCs occurs in @entity421 and revealed that @entity777 ( @entity777 ) may promote CTC attraction. Here, we investigated the underlying mechanisms of @entity777 in @entity5 self-seeding by CTCs. @entity777 suppression inhibited in vitro cell proliferation, migration, and invasion. In addition, rhIL-6 activated the Janus-activated kinase/signal transducers and activators of transcription 3 (JAK/ @entity10433 ) and mitogen-activated protein kinase/extracellular-signal regulated kinase1/2 (MAPK/ @entity8837 ) pathways in vitro. Both pathways increased cell proliferation, but only the JAK/ @entity10433 pathway promoted migration. Suppressing @entity777 inhibited in vivo @entity5 growth and @entity3 . @entity777 suppression or JAK/ @entity10433 pathway inhibition reduced CTC seeding in primary @entity5 . Collectively, @entity777 promotes @entity5 self-seeding by CTCs in a nude @entity19 model. This finding may provide a novel strategy for future therapeutic interventions to prevent @entity421 progression and recurrence.
