[Electrophysiologic and hemodynamic effects of the new XXXX -inducing substance AQ-A 39].

@entity1 @entity341 @entity1817 @entity741 @entity299 @entity1168
AQ-A 39 is a new agent with specific bradycardic action on the sinus node. In this study the electrophysiologic and hemodynamic effects of this compound were investigated in 24 @entity1 with various @entity299 . The results show: AQ-A 39 causes a significant decrease in enhanced sinus rate. The bradycardic action is more profound at higher sinus rates. In sinus rhythm of normal frequency or, in sinus @entity1168 , sinus rate remains unchanged or increases even in the case of @entity1817 . Conductivity of the AV-node is significantly improved. QT- and QTc-interval increase dose dependently. Other cardiac conduction times and refractory intervals are not significantly changed. In exercise-induced @entity741 increased left ventricular filling pressures are diminished. The extent of this decrease parallels the reduction in heart rate. AQ-A 39 appears to be suitable to reduce inadaequate increases in sinus rate, and seems to be of particular interest in surgical cases or intensive @entity341 as well as in @entity741 .
