Effect of Single Preoperative Dose of XXXX on @entity190 and Transfusion in Hip Arthroplasty.

@entity1 @entity190 @entity1031 @entity86 @entity927
BACKGROUND: The aim of the study was to assess the effect of a single intravenous dose of @entity927 administered before surgery in @entity1 undergoing total cementless hip arthroplasty on: intra-, post-, and perioperative blood lost, the number of @entity1 requiring transfusion, the incidence of @entity1031 Material and methods. The study enrolled 124 @entity1 , who were randomly divided into two groups. The experimental group (61 @entity1 ) received an intravenous dose of 15 mg/kg of @entity927 20 minutes before the skin incision, while the control group (63 @entity1 ) did not receive this drug. We analysed intraoperative @entity190 (volume of blood in the aspirator), @entity86 (volume of blood drained), total perioperative @entity190 , and the number of @entity1 requiring transfusion as well as the number of @entity1031 in both groups. RESULTS: In the experimental group, mean intraoperative @entity190 was significantly lower at 216 ml compared to 408.5 ml in the control group (p=0.00421). Postoperative @entity190 on the first postoperative day was also lower in the experimental group (246.3 ml) as compared with the control group (358 ml, p=0.000097). Estimated perioperative @entity190 in the experimental group was lower as well, reaching 779 ml, vs. 1315.5 ml in the control group (p=0.00567). The percentage of @entity1 requiring transfusion in the experimental group (3.27%) was significantly lower than in the control group (22.22%) (p=0.00166). The use of @entity927 did not influence the number of @entity1031 (p=0.3075). CONCLUSIONS: 1. The administration of 15 mg/kg of @entity927 20 minutes before surgery decreases the need for postoperative transfusion of allogeneic blood due to a significant reduction in intra-, post-, and perioperative @entity190 . 2. Seeing that this method does not increase the number of @entity1031 and is simple and inexpensive, it should be considered worthy of recommendation in total cementless hip arthroplasty.
