Association between @entity1192 polymorphism and XXXX .

@entity1 @entity1192 @entity1779 @entity195
BACKGROUND AND PURPOSE: It has been suggested that the @entity1192 ( @entity1192 ) allele 2 is a risk factor for @entity195 ( @entity195 ). Because @entity1779 ( @entity1779 ) often coexists with @entity195 , we examined the @entity1192 polymorphism in @entity1779 . METHODS: In a case-control study, @entity1 with pathologically verified @entity1779 , @entity195 @entity1 without @entity1779 , and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and @entity1192 was genotyped. Logistic regression was used to examine the @entity1192 polymorphism in @entity1779 @entity1 with and without @entity195 compared with @entity195 and non- @entity195 control subjects. RESULTS: There were 42 @entity1 with @entity1779 , 232 @entity195 @entity1 , and 167 non- @entity195 control subjects. In age-adjusted analyses, there was no association between possession of @entity1192 allele 2 and risk of @entity1779 compared with @entity195 control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non- @entity195 control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E epsilon2 or epsilon4 demonstrated the known increased risk of @entity1779 from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the @entity1192 2,2 genotype in @entity1 with @entity1779 and @entity195 compared with those @entity1779 @entity1 who did not have histological evidence indicating @entity195 (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between @entity1779 @entity1 with @entity195 and @entity195 control subjects and between @entity1779 @entity1 without @entity195 and non- @entity195 control subjects did not demonstrate an association between @entity1779 and possession of either the @entity1192 allele 2 or the 2,2 genotype. CONCLUSIONS: The @entity1192 allele 2 or 2,2 genotype does not appear to be a major risk factor for @entity1779 .
