XXXX other than @entity4888 in Singapore: a clinicopathological analysis using recent classification systems.

@entity4888 @entity1 @entity404 @entity2940 @entity706 @entity5 @entity469 @entity2225 @entity784 @entity5893 @entity40934 @entity262 @entity12910 @entity5823 @entity982 @entity1892 @entity8548 @entity405
BACKGROUND: @entity706 other than @entity4888 ( @entity4888 ) are a heterogeneous group with wide variations in clinical presentation, biological behaviour and prognosis. New classification systems have been designed or proposed in recent years, with well-defined disease entities and emphasis on the importance of site. OBJECTIVES: This study aims to analyse a series of @entity706 in an institution-based dermatological setting in Singapore, based on the European Organization for Research and Treatment of @entity5 (EORTC) classification and the World Health Organization (WHO) classification. A secondary objective is to highlight the clinical utility of both classification systems. @entity1 AND METHODS: Forty cases diagnosed over a 12-year period were examined by immunohistochemistry with antibodies targeting CD3, @entity404 , @entity5893 , @entity405 , @entity2225 , @entity5823 , @entity12910 , CD45RO, @entity2940 and @entity469 in @entity982 -embedded specimens. The immunohistological diagnosis was correlated with the clinical presentation and staging investigations for the final diagnosis and the course of disease recorded. RESULTS: Non- @entity4888 @entity784 presenting in the skin comprised 31 cases (78%) and were 3(1/2) times more common than @entity1892 , which comprised nine cases (22%). The common subtypes were @entity8548 , @entity5823 + large cell @entity784 and @entity40934 -like @entity784 . The commonly ascribed B-cell pattern with infiltrates in the mid and deep dermis and perivascular spaces was seen in 60% of @entity784 . Overall, there were equal numbers of primary @entity784 and those due to concurrent or secondary @entity706 . Five of six cases of @entity40934 -like @entity784 had concurrent cutaneous and @entity262 involvement and their median survival was 7 months. CONCLUSIONS: The predominance of @entity784 in this case series closely matched that reported from east Asia; cutaneous @entity1892 are much less common than in Europe. The EORTC classification, which is designed only for primary @entity706 , should be used in conjunction with the WHO classification because of the high prevalence of @entity706 as the secondary site of disease from @entity706 . In addition, @entity40934 -like @entity784 is a primary @entity706 where @entity262 involvement is common at initial presentation. We propose full immunophenotyping and complete clinical evaluation with staging investigations for all @entity1 presenting with @entity706 other than @entity4888 .
