Cryptococcus neoformans: a central nervous system isolate from an @entity791 XXXX that is rhinotropic in a normal @entity19 model.

@entity1 @entity738 @entity39 @entity19 @entity75 @entity1327 @entity1328 @entity375 @entity791
A strain of @entity1327 that was isolated from the cerebrospinal fluid of a @entity1 diagnosed as having @entity791 ( @entity791 ), and that produced cutaneous lesions in experimentally infected, normal @entity19 is described. Although no unusual cutaneous manifestations were noted in the @entity1 's records, this isolate of @entity1327 proved to be dermotropic when injected intravenously into CD-1 @entity19 . The LD50 at 28 days post infection ranged from 3.6-7.5 X 10(5) cells per @entity19 , and in vitro growth rate studies demonstrated that this isolate grew well at 35 degrees C and at 37 degrees C, but did not grow at 40 degrees C and higher. This isolate was rhinotropic producing large @entity75 in the nasal tissues. Other cutaneous tissues affected were the periocular tissues, ears, feet and tail, although the @entity738 were nodular in structure and less @entity39 than the nasal lesions. The brain, lungs, liver, kidneys and spleen also were culture positive for @entity1327 . Histopathologically, each affected tissue examined had large densities of @entity375 cells and a chronic, granulomatous host response. Animals surviving the infection appeared to develop a commensal-type relationship with the infective @entity375 . This is the first report of an isolate of @entity1327 from an @entity791 @entity1 that has caused cutaneous manifestations in an animal model. The model described in this report may be useful for elucidating pathogenic mechanisms of @entity1328 , particularly cutaneous manifestations of the disease.
