Evaluation of antinociceptive activity of XXXX extract of bark ofPolyalthia longifolia.

@entity627 @entity3264 @entity174 @entity19 @entity406 @entity1510 @entity158 @entity1068 @entity1543 @entity2275
ETHNOPHARMACOLOGICAL RELEVANCE: Polyalthia longifolia var. pendula is a very popular herb in Bangladesh due to its traditional uses in treatment of @entity627 , @entity174 and @entity2275 . The present study was conducted to investigate the antinociceptive activity of @entity1068 extract of Polyalthia longifolia (EEPL) bark. MATERIALS AND METHODS: Hot plate and tail immersion tests, @entity1543 -induced writhing test, @entity3264 and @entity406 -induced paw licking tests in @entity19 were employed in this study. In all the experiments EEPL was administered orally at the doses of 50, 100 and 200mg/kg body weight. To investigate the possible participation of opioid system in EEPL-mediated effects, @entity1510 was used to antagonize the action. RESULTS: EEPL showed a significant antinociceptive activity against both heat and chemical-induced nociception. The effects were dose-dependent and significant at the doses of 100 and 200mg/kg of EEPL. Besides, pretreatment with @entity1510 caused significant inhibition of the antinociceptive activity induced by EEPL, revealing the possible involvement of the opioid receptors. CONCLUSION: These results indicate the antinociceptive activity of the bark of P. longifolia and support the ethnomedical use of this plant in treatment of different @entity158 .
