Radiofrequency Ablation Using a Multiple-Electrode Switching System for XXXX with 2.0-5.0-cm Maximum Diameter: Phase II Clinical Study.

@entity1 @entity1143 @entity548 @entity5 @entity2 @entity204 @entity456
UNASSIGNED: Purpose To prospectively evaluate the safety and effectiveness of radiofrequency ablation (RFA) by using a multiple-electrode switching system to treat 2.0-5.0-cm @entity2 . Materials and Methods The institutional review board approved this prospective phase II study. Written informed consent was obtained from all @entity1 . Between September 2009 and July 2011, RFA using two or three radiofrequency (RF) electrodes and a multiple-electrode switching system was performed for @entity2 with a maximum @entity5 diameter of 2.0-5.0 cm in nonsurgical candidates. The primary endpoint was safety, as evaluated using the Common Terminology Criteria for Adverse Events. @entity1 were observed for at least 1 year. Local @entity5 progression and overall survival were analyzed with the Kaplan-Meier method. Results Thirty-three @entity1 (26 @entity1 , seven @entity1 ; mean age, 70.5 years    10.0; age range, 46-87 years) with 35 @entity2 with a mean maximum diameter of 3.0 cm    0.7 (standard deviation; range, 2.0-4.4 cm) underwent treatment in 35 sessions. No procedure-related @entity204 or grade 4 adverse events (AEs) occurred. Grade 3 AEs occurred in four @entity1 (12%), with @entity1143 requiring chest tube placement in two @entity1 , pneumothorax requiring @entity456 in one @entity1 , and @entity548 requiring pulmonary artery coil embolization in one @entity1 . Grade 2 AEs were detected in 13 @entity1 (39%). The 1-year local @entity5 progression and overall survival rates were 12.7% (95% confidence interval [CI]: 1.0, 25.5) and 81.2% (95% CI: 67.6, 94.8). Conclusion RFA with a multiple-electrode switching system may be a safe therapeutic option with which to treat 2.0-5.0-cm lung cancer @entity5 . (  ) RSNA, 2015.
