Preliminary study of @entity146 using @entity2518 in gastric and XXXX .

@entity1 @entity390 @entity146 @entity5 @entity75 @entity648 @entity409 @entity2518 @entity14 @entity3 @entity551
AIM: To investigate the utility of @entity146 ( @entity146 ) using @entity2518 ( @entity2518 ) to detect @entity14 . METHODS: This prospective single-center study investigated inter-subject variability in @entity1 with early-stage @entity14 indicated for endoscopic resection. Subjects were @entity1 with @entity14 who had undergone endoscopic resection between November 2012 and November 2013. Selection criteria included age 20-80 years, either sex, and provision of informed consent. @entity1 were orally administered 20 mg/kg of @entity2518 enteric-coated capsules (SBI ALApromo Co., Tokyo, Japan). Administration of @entity2518 was followed by endoscopic resection of @entity14 , and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope (SAFE-3000 and EB-1970AK, respectively; Pentax, Tokyo, Japan). The primary endpoint was the presence of fluorescence in @entity5 . Endoscopic, macroscopic, and histopathologic findings of @entity5 were assessed. We also evaluated adverse events of the present procedure as a secondary endpoint and examined each @entity1 for the presence of known adverse effects of @entity2518 , namely, hematocytopenia, @entity409 , @entity551 , @entity390 , and photosensitivity. RESULTS: We enrolled 10 @entity1 (7 @entity1 , 3 @entity1 ) (n = 13 lesions: 10 gastric/3 @entity14 ). Fluorescence was detected in 7/13 (53.8%) lesions. No significant differences in sex (male: 55.6% vs female: 50.5%, P = 1.00), age (67.1    1.9 years vs 65.0    2.0 years, P = 0.45), @entity5 color (reddish: 60.0% vs discolored: 33.3%, P = 0.56), @entity5 diameter (15.0    2.1 mm vs 14.2    2.3 mm, P = 0.80), macroscopic type (protruded: 70.0% vs depressed 0%, P = 0.07), histologic type (differentiated type: 58.3% vs 0%, P = 0.46), invasion depth (mucosal layer: 55.6% vs submucosal layer: 33.3%, P = 1.00), lymphatic invasion (present: 33.3% vs absent: 50.0%, P = 1.00), @entity3 (present: 0% vs absent: 54.5%, P = 1.00) or procedure time of endoscopic resection (36.3    8.3 min vs 36.7    9.0 min, P = 0.98) were observed between the @entity1 with and without fluorescence. Fluorescence detection rate tended to be high for @entity75 . @entity409 developed in 4/10 (40.0%) @entity1 . The extent of the @entity409 was a slight increase in transaminases and total @entity648 levels, which spontaneously improved in the @entity1 . None of the @entity1 developed photosensitivity. CONCLUSION: Results of this preliminary study suggest the utility of @entity146 using @entity2518 for screening of @entity14 .
