Generation of tissue factor by @entity1 monocytes: correlation to XXXX complications.

@entity1 @entity49 @entity1003 @entity854 @entity1031 @entity130
@entity1031 complications are often a common pathological consequence of severe soft tissue @entity130 . Recent demonstration that monocytes (M0) produce tissue factor (TF) has led to the suggestion that these TF producing M0 might play a role in @entity1003 . We have previously demonstrated that @entity130 @entity1 with splenectomy develop aberrant monocyte function and this @entity1 group is also known to be at high risk of @entity49 episodes. This paper is an initial report on the use of M0 TF as an indicator of and/or correlated to clotting episodes. Monocytes isolated form the Ficoll-Hypaque purified mononuclear cells of 46 normal individuals, 17 @entity130 @entity1 and 6 surgical controls were assayed at 3 day post-injury intervals for their levels of TF activity. Changes in monocyte TF activity were correlated to increases in the fractional catabolic rate (FCR) of 125 I-fibrinogen. @entity130 @entity1 were retrospectively divided into those whose FcR was elevated to a level indicative of @entity1003 and those whose FCR levels were not associated with @entity854 . All @entity130 @entity1 who exhibited significantly increased FCR experienced @entity1031 episodes and had monocytes whose TF activity was increased an average of 300% (mean = 47 units vs mean = 12 units) over surgical controls. These increase in monocyte TF activity occurred at 6-13 days post injury and preceded clinical manifestation of @entity1003 by 4-6 days. The increased monocyte TF activity demonstrated in this study was significantly correlated to detection of pathologically increased FCR (R = 0.850) and compared to other indices of @entity49 .
