Renal vascular reactivity in the bile duct-ligated XXXX .

@entity8 @entity409 @entity1808 @entity2918 @entity3009 @entity177 @entity35 @entity3352 @entity2661 @entity1063
The @entity8 associated with @entity409 appears to be caused by decreased renal perfusion. Altered renal vascular reactivity (RVR) may contribute to the development of @entity177 . This study was undertaken to assess the effect of bile duct ligation (BDL) on RVR to @entity1063 and @entity1808 in the @entity35 and to evaluate the role of @entity2918 in the modulation of altered RVR. Male @entity35 underwent either sham operation (SO) or BDL. Four days later, isolated kidney perfusions were established. Dose-response curves to @entity1063 (SO, n = 9; BDL, n = 10) and @entity1808 (SO, n = 7; BDL, n = 9) were obtained. The perfusate was modified to contain @entity3352 , 10(-6) mol/L, and dose-response curves to @entity1063 (SO, n = 10; BDL, n = 8) and @entity1808 (SO, n = 4; BDL, n = 8) were obtained as well. Baseline resistances did not differ between any of the groups. RVR to @entity1063 did not appear to be altered by BDL; however, increased RVR to @entity1063 was unmasked by inhibition of @entity3009 synthesis. BDL did not affect the RVR to @entity1808 with or without @entity3352 . BDL is associated with an increase in renal vascular sensitivity to @entity1063 , which is balanced by a compensatory increase in renal @entity3009 activity in response to @entity1063 stimulation. These findings are consistent with theories that decreased renal perfusion associated with @entity409 may be mediated by @entity2661 .
