Prevalence rates and clinical implications of XXXX "with mixed features" as defined by @entity4987 .

@entity1 @entity162 @entity4987 @entity308
BACKGROUND: We investigated the increase in the prevalence of @entity162 with mixed features following the replacement of DSM-IV-TR criteria with @entity4987 criteria. Additionally, we examined the clinical implications of the use of "with mixed features" as a specifier with @entity162 . METHOD: We retrospectively reviewed medical charts from 2003 to 2013. A total of 331 @entity1 diagnosed with @entity162 using the DSM-IV TR were enrolled and categorized into four groups: @entity162 /hypomanic with mixed features, @entity162 /hypomanic without mixed features, @entity308 with mixed features, and @entity308 without mixed features. These classifications were made in accordance with the @entity4987 definition of @entity162 "with mixed features." Changes in the prevalence, demographic and clinical characteristics were compared among the groups. RESULTS: The prevalence rates of mixed features were significantly different when using the @entity4987 criteria vs. the DSM-IV-TR criteria. @entity1 with mixed features had a younger age of onset, younger age at hospitalization, more frequent hospitalizations for mixed episodes, and greater suicide risk compared with @entity1 without mixed features. LIMITATIONS: Retrospective study may have resulted in under diagnosis of mixed states. CONCLUSIONS: An approximately three-fold greater risk for mixed features was observed in @entity1 with @entity162 when using the @entity4987 criteria than when using the DSM-IV-TR criteria. The additional @entity1 may represent @entity1 with sub-syndromal mixed features and could indicate that @entity1 with mixed features are underdiagnosed.
