Full-spectrum light phototherapy for XXXX .

@entity1 @entity483 @entity225 @entity1097 @entity272 @entity3646
BACKGROUND: @entity483 ( @entity483 ) is a @entity272 resulting in a profound deterioration in quality of life. The FSL   is a newly developed phototherapy device generating full-spectrum light (FSL) with a continuous wavelength (320-5000 nm). This study aimed to evaluate the efficacy and safety of FSL   phototherapy in @entity483 . METHODS: We enrolled 38 @entity1 with moderate to severe @entity483 in this open, randomized, controlled, prospective study. In the FSL-irradiated group (20 @entity1 ), irradiation was conducted twice per week for 4 consecutive weeks. In the control group (18 @entity1 ), only emollient application was allowed. SCORing @entity1097 (SCORAD) values were obtained at baseline, week 4 and 8. @entity1 were asked to give subjective assessments of improvement and laboratory tests including serum eosinophil counts, ECP levels, IgE levels and 22 cytokine levels were performed. RESULTS: In the FSL-irradiated group, the mean SCORAD value decreased significantly after 4 weeks of phototherapy and remained reduced for a further 4 weeks after the cessation of treatment. In the control group, the mean SCORAD value did not change significantly over the study period. @entity1 ' subjective assessments indicated good to excellent responses in 75% of the FSL-irradiated group, by contrast with 50% of the control group. The mean values for serum eosinophil counts, @entity3646 and @entity225 levels decreased significantly after FLS phototherapy. No serious adverse effects were reported. CONCLUSIONS: In this study, we showed that FSL   phototherapy can be an effective and safe treatment option in @entity483 .
