Association of @entity7116 @entity38302 polymorphism with susceptibility to XXXX : A systematic review and meta-analysis.

@entity38302 @entity31 @entity29 @entity7116 @entity30
OBJECTIVE: Association of @entity7116 ( @entity7116 ) gene polymorphism with susceptibility to @entity29 have been investigated in a number of epidemiological studies, but the results are inclusive. The aim of this meta-analysis was to more precisely estimate the relationship. METHODS: The databases of Pubmed and CBM updated to October, 2014 were retrieved. Random- or fixed-effect model was used to estimate odd radio (OR) and corresponding 95% confidence interval (95%CI) on the basis of heterogeneity. RESULTS: Seven articles containing 2196 @entity30 ( @entity30 ) cases, 1588 @entity31 ( @entity31 ) cases and 4126 controls were identified. We detected a significant association between @entity7116 @entity38302 polymorphism and IBD susceptibility in overall population (GG vs. GT+TT, OR=0.855, 95%  CI=0.760-0.962, P=0.009), but not in Caucasian and Asian population, respectively. No association was detected between @entity38302 polymorphism and @entity30 susceptibility in overall, Asian and Caucasian population, respectively. Interestingly, a significant association was detected between @entity38302 with @entity31 susceptibility in overall population (G vs. T, OR=0.881, 95%  CI=0.798-0.972, P=0.012; GG vs. GT+TT, OR=0.788, 95%  CI=0.679-0.914, P=0.002; GG vs. TT, OR=0.683, 95%  CI=0.498-0.937, P=0.018) and Caucasians (GG vs. GT+TT, OR=0.833, 95%  CI=0.701-0.990, P=0.038; GG+GT vs. TT, OR=0.667, 95%  CI=0.456-0.975, P=0.037; GG vs. TT, OR=0.636, 95%  CI=0.433-0.934, P=0.021), respectively, and a possible association was found in Asian population (GG vs. GT+TT, OR=0.709, 95%  CI=0.503-0.998, P=0.049). CONCLUSIONS: @entity7116 @entity38302 gene is IBD risk factor, and this gene polymorphism is associated with @entity31 susceptibility, especially in Caucasians. To confirm these findings, further studies with more sample size are required for a definitive conclusion.
