CSF biochemistries, XXXX metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers.

@entity251 @entity10420 @entity146 @entity988 @entity5581 @entity23 @entity750 @entity1130 @entity413 @entity14006
BACKGROUND: There is an extensive literature describing a central @entity750 deficit in @entity988 and fire setters. In the present study, we investigated biochemical concomitants of @entity23 and @entity146 , and the physiological consequences of reduced central serotonin turnover. METHODS: Forty-three impulsive and 15 nonimpulsive alcoholic offenders and 21 healthy volunteers were studied in the forensic psychiatry ward of a university psychiatric department. The subjects underwent lumbar punctures and oral @entity413 and @entity14006 challenges, and their diurnal activity rhythm was measured with physical activity monitors. Discriminant function analyses were used to investigate psychophysiological and biochemical concomitants of aggressive and @entity146 . RESULTS: Alcoholic, impulsive offenders with @entity10420 had low mean cerebrospinal fluid (CSF) @entity1130 ( @entity5581 ) and corticotropin levels and high mean CSF @entity251 concentrations. Compared with healthy volunteers, they showed increased physical activity during the daytime. Alcoholic, impulsive offenders with @entity23 had a low mean CSF @entity5581 concentration and blood @entity413 nadir after an oral @entity413 challenge, and desynchronized diurnal activity rhythm. Healthy volunteers had mean CSF @entity5581 concentrations that were intermediate between those of alcoholic, impulsive and nonimpulsive offenders. Alcoholic, nonimpulsive offenders had a significantly higher mean CSF @entity5581 concentration than all the other groups, including healthy volunteers. CONCLUSIONS: In the present sample, a low CSF @entity5581 concentration was primarily associated with @entity23 and high CSF @entity251 concentration, with @entity146 or interpersonal violence.
