Dietary method for reducing fluctuations in XXXX .

@entity1 @entity1522 @entity535 @entity191
Motor fluctuations and non-response to carbidopa-levodopa (Sinemet) therapy are major problems in the long-term management of @entity191 . Levodopa manipulation, addition of adjuvants, and drug holidays are often unsuccessful. Others have shown that the clinical state of stabilized Parkinsonians can be reversed with intravenous administration of large neutral @entity1522 . Reasoning that dietary protein might precipitate motor oscillations and non-response, a low-protein daytime diet (7 g) was offered to fifteen @entity1 . Eighty-six percent of this sample demonstrated immediate sensitivity to Sinemet. While on a low-protein diet, @entity1 ' clinical function was predominantly choreatic. Eight @entity1 required a 10-60 percent reduction in their daily levodopa dose in order to minimize this choreatic tendency. Discontinuation of adjuvants did not compromise motor independence. Conversely, while on a high-protein diet (160 g), @entity1 were predominantly immobile with markedly elevated plasma @entity535 and levodopa levels. Consequently, elimination of dietary protein from breakfast and lunch can offer an effective and easily modified method for the amelioration of motor fluctuations and non-response to Sinemet in @entity191 during working hours.
