Mood and XXXX as early manifestations of medical illness: a systematic review.

@entity1375 @entity162 @entity308 @entity788 @entity146 @entity699 @entity148 @entity2360 @entity583 @entity791 @entity2742
BACKGROUND: Affective disturbances involving alterations of mood, @entity148 and @entity146 may be early symptoms of medical illnesses. The aim of this paper was to provide a systematic review of the literature with qualitative data synthesis. METHODS: MEDLINE, PsycINFO, EMBASE, Cochrane, and ISI Web of Science were systematically searched from inception to February 2014. Search terms were 'prodrome/early symptom', combined using the Boolean 'AND' operator with ' @entity148 / @entity308 / @entity162 /hypomania/ @entity146 /irritable mood/hostility', combined with the Boolean 'AND' operator with 'medical illness/medical disorder'. PRISMA guidelines were followed. RESULTS: A total of 21 studies met the inclusion criteria and were analyzed. @entity308 was found to be the most common affective prodrome of medical disorders and was consistently reported in @entity699 , @entity1375 , @entity2742 , @entity788 , @entity583 , @entity2360 , and @entity791 . @entity162 , @entity148 and @entity146 were less frequent. CONCLUSIONS: Physicians may not pursue medical workup of cases that appear to be @entity146 in nature. They should be alerted that disturbances in mood, @entity148 and @entity146 may antedate the appearance of a medical disorder.
