Oral XXXX among HIV-positive intravenous drug abusers: a clinicopathologic and ultrastructural study.

@entity1 @entity16888 @entity7553 @entity5132 @entity465 @entity1082 @entity42912 @entity791 @entity4092
During a prospective investigation of oral lesions of 120 consecutive @entity1 positive for @entity1 @entity465 virus, belonging to the intravenous drug abuser risk group and other risk categories, we observed @entity42912 ( @entity42912 ) in 23 cases (19%). The median age of the @entity1 was 27 years (range, 20 to 50 years). Twenty @entity1 were @entity1 and three were @entity1 . All but two of the twenty three @entity1 used intravenous drugs for a median period of 6 years (range, 5 to 18 years) and were involved in several episodes of needle sharing. Eight @entity1 were also bisexual, one @entity1 was homosexual, and one @entity1 was hemophiliac and bisexual. Eleven @entity1 had @entity4092 , five had @entity16888 , six had @entity16888 , and one had @entity791 . In all @entity1 , @entity42912 lesions were localized on the lateral borders of the tongue. In twelve @entity1 , the lesion was unilateral, and in eleven @entity1 , it was bilateral. Microscopically, hyperparakeratosis and the presence of koilocytes were observed in all cases. Surface @entity7553 could be detected with staining with periodic acid-Schiff in two thirds of the cases. In four cases, electron microscopy showed the presence of intracellular and extracellular hyphae of @entity5132 in the parakeratin layer associated with coccobacilli in the spaces between surface epithelial cells. The spinous layer included koilocytes, which had a clear cytoplasmic matrix, sparse organelles and tonofilaments, and dispersed chromatin. These cells were found to be infected by a herpes-type virus in all cases examined. There was no ultrastructural evidence of @entity1082 in the nuclei of the epithelial cells.(ABSTRACT TRUNCATED AT 250 WORDS)
