Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset XXXX : A prospective cohort study.

@entity1 @entity32889 @entity1468
OBJECTIVES: We evaluated the biological interaction between blood pressure (BP) and uterine artery Doppler (UAD) in the second trimester for early-onset @entity1468 (EO-PE) risk. STUDY DESIGN: A prospective cohort study. MAIN OUTCOME MEASURES: In 2410 pregnant @entity1 , mean pulsatility index (mPI) and mean notch depth index (mNDI) were examined by UAD at 16-23weeks' gestation. We defined EO-PE as PE with onset at <34weeks, abnormal UAD as coexistence of mPI   90th percentile and mNDI   90th percentile, and high BP as systolic BP/diastolic BP   120/80mmHg. Abnormal UAD and high BP were combined as a series of dummy variables, and were entered into a logistic regression model. The relative excess risk due to biological interaction (RERI) was calculated using the following equation: RERI=odds ratio (OR) in @entity1 with both high BP and abnormal UAD - OR in @entity1 with high BP alone - OR in @entity1 with abnormal UAD alone +1. RERI   10 was considered as strong. RESULTS: EO-PE and @entity32889 ( @entity32889 ) occurred in 1.1% and 1.2%, respectively. Adjusted odds ratio (95% CI) in @entity1 with abnormal UAD alone, high BP alone, and both high BP and abnormal UAD for predicting EO-PE was 4.3 (0.37-49), 12 (2.6-55) and 85 (17-422), respectively; and that for predicting @entity32889 was 6.3 (1.5-27), 6.1 (2.1-17) and 15 (3.6-61), respectively. The RERI for EO-PE and @entity32889 was 70 and 3.3, respectively. CONCLUSION: High BP and abnormal UAD may have a strong biological interaction for the occurrence of EO-PE.
