The measurement of corneal epithelial thickness in response to XXXX using optical coherence tomography.

@entity2687 @entity519 @entity3279 @entity8650
PURPOSE: To determine if corneal epithelial thickness increases in association with @entity3279 induced by wearing soft contact lenses during eye closure. DESIGN: Experimental study. METHODS: One eye (randomly selected) of twenty noncontact lens wearers (10 males and 10 females, age 35.6 +/- 9.6 years) was patched during 3 hours of @entity8650 ( @entity8650 ) wear and the contralateral eye acted as a control. Corneal and epithelial thickness of both eyes was measured before and after @entity8650 wear using optical coherence tomography (OCT). RESULTS: Immediately after contact lens @entity2687 was increased significantly by 13.8 +/- 2.3% (mean +/- SD) compared with baseline (P <.0001, paired t test) and after 100 minutes was still 4.5 +/- 2.3% thicker than baseline (P <.0001, paired t test). The control eyes showed no change in total corneal thickness (P >.05, paired t test). Immediately after contact lens removal, corneal epithelial thickness was increased by 1.7 +/- 4.8%, but this change was not statistically significant (P >.05, paired t test). Following contact lens removal, epithelial thickness changed significantly (Repeated measure analysis of variance [Re-ANOVA]: F((7,133)) = 4.91, p(H-F) < 0.001) over the next 100 minutes with thinning recorded at 60, 80, and 100 minutes (P <.05, paired t test). There was no significant change over time in epithelial thickness of the control eyes (Re-ANOVA: F(4, 76) = 0.91, p(H-F) = 0.464). CONCLUSION: OCT demonstrated that corneal epithelial thickness does not increase in response to @entity519 from @entity8650 wear and eye closure, in contrast to a significant @entity2687 .
