Screening in pregnancy with unconjugated XXXX compared with total @entity11111 .

@entity1 @entity11111
An obstetric population was screened 'blind' by measuring unconjugated @entity11111 (ucE3) and total @entity11111 (tE3) in serum. The purpose was firstly to ascertain the predictive values of ucE3 for the prediction of low birth weight and distressed neonates (perinatal deaths included), and secondly to compare the predictive values of ucE3 and tE3. The main material consisted of 1018 singleton pregnancies with known term, who would not have undergone @entity11111 (E3) measurement had it not been for this investigation. The study was carried out prospectively, and the obstetricians had no knowledge of the E3 values in the screened pregnancies. When at least one of the ucE3 values was low, the risk of having a small for gestational age (SGA) @entity1 was 22%. Low tE3 implied a 27% risk. When both were low, the risk of a SGA @entity1 was 54%. The percentages of SGA @entity1 found were 18, 19, and 12%, when ucE3, tE3, or both respectively, were low. ucE3 does not appear to be superior to tE3. From the predictive values found in this study, screening of a total obstetric population with ucE3 and/or tE3 cannot be recommended.
