Assessment of bone marrow histology in XXXX : correlation with clinical factors.

@entity1 @entity2617 @entity4383 @entity236 @entity978
Bone marrow biopsies of 491 untreated and 170 treated @entity1 with @entity978 ( @entity978 ) were investigated. Marrow involvement was found in 10% and 25% respectively. Positive biopsies were rare in clinical stages I and II (1% and 2%), but the incidence rose to 25% and 45% in stages III and IV. @entity978 @entity1 with @entity4383 in lymph node histology had a low incidence of bone marrow involvement (4%), while those with lymphocytic depletion had a high incidence (22%). Of nine clinical and six histological parameters tested, bone marrow involvement proved to be the most significant predictive factor indicating an unfavourable course. Moreover, classification of the bone marrow manifestations according to the degree of @entity2617 , proved to be simple, reproducible and prognostically significant. Normal haematopoietic tissue was found in only 20% of the negative biopsies of untreated @entity1 . The remaining 80% were characterized by a variety of non-specific reactions. These included @entity236 and leukaemoid and exudative reactions each of which indicated a poor prognosis; and epithelioid-cell granulomas and lymphoid nodules which predicted favourable survival curves. Adequate bone marrow biopsy is a valuable part of the investigation of @entity1 with @entity978 , as both positive and negative biopsies provide information of prognostic significance.
