Influence of smoking behavior in relation to plasma XXXX and @entity1881 on sister chromatid exchanges in @entity1 peripheral blood lymphocytes.

@entity1 @entity1881 @entity904 @entity3731
The present study was undertaken to evaluate the contribution of various individual characteristics and lifestyle factors on @entity3731 ( @entity3731 ) frequencies in @entity1 peripheral blood lymphocytes (PBLs). These also included associations between plasma @entity904 and @entity1881 and @entity3731 frequencies. The study population consisted of 50 healthy, smoking and nonsmoking, male and female volunteers, ages 22-49. @entity3731 frequencies in PBLs were significantly higher in smokers than in nonsmokers. @entity3731 frequencies correlated with variables of smoking habits and history, with the number of pack-years smoked correlating most strongly (r = 0.501; P < 0.001). Inverse but nonsignificant correlations were observed between plasma @entity904 and @entity1881 levels and @entity3731 frequencies in PBLs. In addition, with the use of multiple regression analysis, significant associations were found with age and possible occupational exposure after adjustment for smoking habits (r2 = 0.428; P = 0.0001). For males (n = 20), @entity3731 frequencies were found to be associated significantly with the number of cigarettes smoked per day and possible occupational exposure (r2 = 0.485; P < 0.01). @entity3731 frequencies in PBLs of females (n = 30) were associated positively with the number of pack-years smoked and age, and significantly inversely correlated with plasma @entity1881 concentrations (r2 = 0.586; P = 0.0001). After exclusion of possible occupationally exposed @entity1 (n = 8) from the study population and adjustment for the effects of age and smoking behavior, a weak inverse correlation was found between plasma @entity1881 and @entity3731 frequencies (r = -0.286; P = 0.0732).(ABSTRACT TRUNCATED AT 250 WORDS)
