Globe conserving treatment of the only eye in XXXX .

@entity1 @entity548 @entity231 @entity5 @entity1713 @entity204 @entity995
AIMS: To quantify the rates of eye preservation and @entity1 survival, @entity5 relapse and recurrence, and development of new @entity5 in the remaining eye of @entity1 with @entity995 with one eye already enucleated. Also, in the same @entity1 , to describe the types of primary and secondary treatment procedures, and to define the anatomical outcome. METHODS: This is a retrospective observational case series report. The study @entity1 consisted of 107 @entity1 with @entity995 with one eye enucleated within 1 month of baseline examination and had their remaining eye treated conservatively. The main outcome measure were: primary treatment failures, new @entity5 , enucleation of the only eye, @entity204 , remission, and anatomical outcomes ( @entity1713 , @entity548 , and @entity231 ). RESULTS: The median age at diagnosis was 8.4 (range 0.2-44, SD 10.1) months with a median ophthalmic follow up of 44.3 (8.1-114, SD 10.1) months. In 22 of the 107 @entity1 (21%) the treated eye was in Reese Ellsworth groups I or II and in the remaining 85 (79%) in groups III-V at diagnosis. The primary treatment was cryotherapy in 14% (15/107) of eyes, radioactive plaque brachytherapy in 3.7% (4/107), and chemotherapy in 10% (11/107). It was lens sparing radiotherapy in 37% (40/107), whole eye radiotherapy in 29% (31/107), combined radiotherapy and chemotherapy in 2.8% (3/107), chemothermotherapy in 0.9% (1/107), and combined focal therapy in 1.8% (2/107). The primary treatment failed to achieve @entity5 control during the follow up period in 37% (40/107) of eyes. In 17 eyes failure was due to inadequate control of the presenting @entity5 , in 16 to development of a new @entity5 , and in eight eyes to a combination of both. 35 (88%) of the 40 failures were managed by secondary conservative treatment and the remaining five were treated by enucleation of the only eye. There were eight (7.4%) deaths and the 3 year survival rate was 93% (100/108). Anatomical results included @entity548 in four cases, tractional @entity1713 also in four cases, and 24 @entity1 required @entity231 surgery. CONCLUSIONS: Aggressive conservative treatment achieved a good rate of globe salvage without impairing survival.
