Expression of mRNAs encoding subunits of the XXXX receptor in developing @entity35 brain.

@entity4477 @entity1024 @entity4319 @entity4476 @entity4474 @entity4320 @entity143 @entity35
Developmental changes in the levels of @entity1024 ( @entity143 ) receptor subunit mRNAs were identified in @entity35 brain using solution hybridization/RNase protection assays. Pronounced increases in the levels of mRNAs encoding @entity4474 and @entity4476 were seen in the cerebral cortex, hippocampus, and cerebellum between postnatal days 7 and 20. In cortex and hippocampus, the expression of @entity4319 mRNA was high in neonatal @entity35 and remained relatively constant over time. In contrast, in cerebellum, the level of @entity4319 mRNA was highest at postnatal day 1 and declined to undetectable levels by postnatal day 28. @entity4477 mRNA was not detectable in cerebellum before postnatal day 11, after which it increased to reach adult levels by postnatal day 28. In cortex, the expression of @entity4476 and @entity4319 mRNAs corresponds to the previously described developmental profile of @entity143 receptor subtypes having low and high affinities for @entity4320 , i.e., a delayed expression of @entity4476 correlating with the late expression of low-affinity @entity4320 sites. In cortex and hippocampus, the predominant splice variants of @entity4474 were those without the 5' insert and with or without both 3' inserts. In cerebellum, however, the major @entity4474 variants were those containing the 5' insert and lacking both 3' inserts. The results show that the expression of @entity4474 splice variants and NR2 subunits is differentially regulated in various brain regions during development. Changes in subunit expression are likely to underlie some of the changes in the functional and pharmacological properties of @entity143 receptors that occur during development.
