[Gene polymorphism of @entity3335 and genetic susceptibility to XXXX ].

@entity1 @entity3335 @entity5 @entity2 @entity72941 @entity13284
BACKGROUND _ OBJECTIVE: @entity72941 polymorphism is located in the promoter region of @entity3335 ( @entity3335 ) gene was found to be associated with @entity2 susceptibility; however, this association in Chinese population remained unclear. The aim of this study was designed to explore this association in Chinese population. METHODS: @entity3335 genotypes in 98 cases of primary @entity2 and 112 @entity1 of healthy control were detected using PCR-restriction fragment length polymorphism assay(PCR-RFLP) in a case-control molecular epidemiology study. The association between this gene polymorphism and the risk of @entity2 in Chinese population was examined through comparing odds ratio(OR) and 95% confidence interval(CI) between two groups. RESULTS: In healthy control group, the frequencies of @entity1 carrying G/G, @entity13284 , and A/A genotypes were 47.3%, 42.9%, and 9.8%, respectively. In @entity5 group, the frequencies of the @entity1 carrying above three genotypes were 63.3%, 33.7%, and 3.0%, respectively. There was no significant difference of the frequencies of heterozygote @entity13284 between two groups (P >0.05). However, The A/A genotype was found significantly higher in @entity5 group than that in healthy control group(P< 0.025). The risk of @entity2 for @entity1 carrying at least one A allele was only 52% of the @entity1 carrying G/G genotype (95% CI 0.29-0.93). In smoking population, allele A showed to be a significant protective factor (OR=0.41,P< 0.025), while such protective role was not observed in non-smoking group(P >0.25). CONCLUSION: @entity3335 gene polymorphism was associated with susceptibility of @entity2 in Chinese population. The risk of @entity2 was decreased in the @entity1 carrying allele A.
