Thermochemotherapy (combined XXXX and hyperthermia) with or without hyperglycemia as an adjuvant to radiotherapy.

@entity5 @entity786 @entity1492 @entity519 @entity413
Our previous study demonstrated the presence of a thermochemotherapy-resistant cell fraction in a @entity5 . The present study investigated whether thermochemotherapy-resistant cells are radioresistant and whether thermochemotherapy changes the size of @entity519 cell fraction in the @entity5 . Early generation isotransplants of a spontaneous @entity1492 , @entity5 , were used. A radiation dose that yields 50% @entity5 control rate in 150 days after local irradiation, TCD50, was determined. @entity786 (CY) was the test agent. TCD50 values of the 4 mm @entity5 following gamma-ray alone given under @entity519 conditions or in air were 80.9 or 65.8 Gy, respectively. Thermochemotherapy reduced TCD50 values congruent to 20 Gy, suggesting that thermochemotherapy resistant cells are not identical to the radioresistant cells. @entity413 administered 60 min before thermochemotherapy further reduced TCD50 values. Foot-reaction scored in the @entity5 -controlled animals was significantly less severe following combined thermochemo- and radiotherapy compared to that following radiotherapy alone. Acute foot reaction studies also supported this observation. These results indicated that thermochemotherapy could be an excellent adjuvant to radiotherapy. Further studies using a 6 mm @entity5 indicated that thermochemotherapy was less effective on the large @entity5 than on the small @entity5 . Indirect analysis showed no significant changes in the size of @entity519 cell fraction following thermochemotherapy.
