XXXX is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Troms   Study.

@entity1 @entity8 @entity470 @entity1009 @entity1011 @entity414
BACKGROUND: The role of @entity414 in development of @entity8 ( @entity8 ) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in @entity414 on renal outcome has not been assessed previously. We aimed to study the impact of change in serum @entity414 (SUA) as well as baseline SUA on the development of @entity8 . METHODS: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and @entity8 (defined as albumin- @entity1011 -ratio (ACR) >= 1.13  mg albumin/mmol @entity1011 and/or @entity470   <   60  ml/ @entity1009 .73  m(2)) in a large cohort from a general population participating in the Troms   Study (n   =   2637). @entity1 were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13  years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with @entity8 and each component of @entity8 after 7 and 13  years as the dependent variables. Adjustments were made for baseline @entity470 , cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. RESULTS: After excluding @entity1 with @entity8 at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of @entity8 after 7  years (odds ratio 2.00, (95  % CI 1.45, 2.75)). Odds ratio for @entity8 in SUA increasers after 13  years was 2.18 (95  % CI 1.71, 2.79). The risk of developing ACR >= 1.13  mg/mmol alone was not significantly increased after 7  years (odds ratio 1.30 (95  % CI 0.90, 1.89), but after 13  years (odds ratio 1.43 (95  % CI 1.09, 1.86)). An increase in baseline SUA of 59   mol/L (1  mg/dL) gave an odds ratio for @entity8 after 13  years of 1.16 (95  % CI 1.04, 1.29). CONCLUSION: An increase in SUA during follow-up was associated with an increased risk of developing @entity8 after 7 and 13  years.
