[Lipoprotein(a): risk factor for XXXX important to take into account in practice].

@entity1 @entity101 @entity66 @entity731 @entity2299 @entity3452 @entity453
@entity453 is a leading cause of death in France. Some of its risk factors are well identified such as age, smoking, @entity101 and @entity2299 , but some others such as lipoprotein (a) ( @entity3452 )) are still under investigation. @entity3452 ) is an LDL-like particle to which is linked an apolipoprotein (a). The latter shows a high sequence homology with plasminogen that gives @entity3452 ) thrombogenic properties in addition to its atherogenic capacity. Many epidemiological studies have shown that a high plasma level of @entity3452 ) is a risk factor for coronary, cerebral and peripheral @entity731 . Out of thirteen prospective studies, ten have confirmed this result. The negative results from the three remaining studies were probably due to either the inadequate storage of the samples or the preventive drug treatment given to the @entity1 during the studies and to the lack of standardization of @entity3452 ) assays. More over it has been shown that beside high plasma @entity3452 ) level, the presence of a low molecular weight Apo(a) isoform is also related to a higher incidence of @entity453 . This review of the literature clearly demonstrates the relationship between @entity3452 ) and @entity731 , and the need to measure @entity3452 ) in order to better evaluate the risk of @entity731 especially in @entity1 with a hyper LDLemia an early cardio- or @entity66 or a family history of @entity731 . Management of @entity1 with high @entity3452 ) concentrations should be directed at minimizing all other risk factors for @entity731 .
