Effects of subchronic intermittent exposure to XXXX in Swiss Webster @entity19 .

@entity11961 @entity137 @entity3727 @entity1388 @entity19 @entity7677 @entity4488 @entity3810 @entity99
Swiss Webster @entity19 were treated to determine whether the inhalational anesthetic, @entity3810 ( @entity3727 ), causes @entity137 and enhances anesthetic defluorination. Two-hundred and sixteen young adult male and female @entity19 were exposed to room air or to 5,000 (.5%), 50,000 (5%) or 500,000 (50%) @entity3727 for four hours per day, five days per week for periods up to fourteen weeks. Body weight was measured twice weekly throughout the experiment. Liver, kidney, spleen and testis were weighed and examined histologically along with brain, stomach, seminal vesicle, and ovary for evidence of @entity99 . Blood smears were examined microscopically and complete blood count, differential white cell count, and reticulocyte and platelet counts were performed. In addition, liver microsomal @entity7677 content and the rates of defluorination of @entity4488 and @entity11961 were determined. The maximum tolerated concentration of @entity3727 was approximately 5000,000 ppm. Even at this high dose, there was no evidence of organ damage. Following @entity3727 exposure, neither the hepatic microsomal @entity7677 content nor the rates of anesthetic defluorination were increased; the rate of in vitro inorganic @entity1388 production was greater for @entity11961 than for @entity4488 . Since there was no evidence of specific @entity137 or of enzyme induction or inhibition, it was concluded that @entity3727 is a comparatively nontoxic inhalational anesthetic under the conditions of this study.
