99mTc-Pertechnetate imaging for detection of XXXX : a systematic review and meta-analysis of the pertinent literature..

@entity1 @entity360 @entity356
BACKGROUND AND AIMS: 99mTc-pertechnetate scintigraphy has long been used for detection of @entity356 ( @entity356 ) in the medical practice and evaluation of @entity1 with lower @entity360 . In the current study, we reviewed the available medical literature in this regard. METHODS: Medline and SCOPUS were searched for relevant studies. Studies with sample size of at least 5 @entity1 which provided enough numerical data to calculate the sensitivity and/or specificity of 99mTc-pertechnetate for detection of @entity356 were includ ed in the systematic review. RESULTS: Overall 40 studies were included in our systematic review. Overall diagnostic indices of the 99mTc-pertechnetate scintigraphy for @entity356 diagnosis were: sensitivity 92.1% [95% CI: 90.2-93.8], specificity 95.4% [943-963], positive likelihood ratio 16.5 [9.9-27.], negative likelihood ratio 0.15 [0.1-0.2], diagnostic odds ratio 120.7 [73-199]. The pooled sensitivity was higher for studies using H2 blockers as a premedication (92.4% vs. 86.4%), studies using delayed imaging (943% vs. 88.4%), @entity1 (92.3% vs. 81.8%), and @entity1 with @entity360 (953% vs. 75.3%). CONCLUSIONS: 99mTc-pertechnetate imaging is a highly accurate diagnostic modality for detection of @entity356 . This imaging is more accurate in @entity1 and @entity1 presenting with @entity360 . Premedication with H2 blockers and delayed imaging can increase the diagnostic accuracy and should be routinely included in the imaging protocol.
