@entity5019 reduces @entity2819 -mediated effects on neurotrophic factor expression in the XXXX hippocampal @entity1249 region.

@entity2136 @entity664 @entity1249 @entity5019 @entity2819 @entity19505 @entity35
The transcription of neurotrophic factors, i.e., @entity664 ( @entity664 ) and @entity2136 ( @entity2136 ) is regulated by glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) activation despite the lack of a classical glucocorticoid response element in their promoter region. A time course for @entity2819 (10 mg/kg, s.c.) in adrenalectomized @entity35 revealed a peak hormone effect at the 4 hr time interval for @entity664 (110-204% increase), @entity2136 (53-67% decrease), GR (53-64% decrease), and MR (34-56% decrease) mRNA levels in all hippocampal subregions using in situ hybridization. @entity5019 mRNA levels were affected exclusively in the dentate gyrus after 50 min to 2 hr (38-46% decrease). Furthermore, it was evaluated whether @entity2819 regulation of these genes depends on interactions with the transcription factor complex @entity19505 . @entity5019 antisense oligodeoxynucleotides were injected into the dorsal hippocampus of adrenalectomized @entity35 . @entity2819 was given 2 hr later, and the effects on gene expression were measured 4 hr later. In @entity1249 , antisense treatment significantly and selectively enhanced the hormone action on the expression of @entity664 (44% enhanced increase) and @entity2136 (38% enhanced decrease) versus control oligodeoxynucleotide treatment. In addition, an upregulation of @entity5019 expression (89% increase) was found. There were no effects of @entity5019 antisense on hippocampal GR and MR expression. Thus it seems that a tonic @entity5019 mechanism exists within @entity1249 , which reduces GR- and MR-mediated effects on expression of @entity664 and @entity2136 .
