Urinary trypsin inhibitor levels are reduced in cerebrospinal fluid of XXXX and @entity1652 @entity1 during relapse.

@entity1 @entity32 @entity17 @entity1494 @entity1652 @entity3878 @entity717 @entity15 @entity413
BACKGROUND: Neutrophil-mediated @entity32 plays an important role in the pathogenesis of @entity15 ( @entity15 ) and @entity1652 ( @entity1652 ). Concentrations of @entity1494 ( @entity1494 ) have attracted attention as a useful index of the status of inflammatory response. Evidence suggests serum @entity1494 levels are increased in some inflammatory diseases, but little attention has been paid to cerebrospinal fluid (CSF) levels of @entity1494 . OBJECTIVE: To measure CSF concentration of @entity1494 and determine its relationship with disease activity in @entity15 and @entity1652 . METHODS: CSF @entity1494 was measured by an enzyme-linked immunosorbent assay in 18 @entity15 @entity1 , 28 @entity1652 @entity1 and eight controls. RESULTS: CSF @entity1494 concentrations in @entity15 and @entity1652 groups were both significantly lower than those in controls. Expanded disability status scale scores of @entity15 and @entity1652 revealed a trend of @entity717 with decreased CSF @entity1494 level. The CSF @entity1494 concentrations were not significantly associated with CSF white blood cell counts, total protein, @entity413 and @entity3878 concentrations in @entity15 and @entity1652 subgroups. CONCLUSIONS: Our results indicate a reduced @entity1494 level in CSF of @entity15 and @entity1652 @entity1 . The levels were associated with the severity of the two @entity17 during relapse.
