Genomic abnormalities in XXXX .

@entity1 @entity19602 @entity8058 @entity2557 @entity4910 @entity27204 @entity1582 @entity2008 @entity7513
Translocations involving immunoglobulin (Ig) loci and chromosome 13 monosomy ( @entity27204 ) are frequent cytogenetic findings in @entity1582 ( @entity1582 ). Similar @entity2008 have been identified in the @entity8058 ( @entity8058 ), but their prevalence and significance remain uncertain. Bone marrow from 72 @entity1 with @entity8058 (n = 62) and smoldering @entity1582 (n = 10) was evaluated for translocations between the @entity7513 ( @entity7513 ) and chromosomes 4, 11, and 16, translocations involving Ig light chain-lambda ( @entity19602 -lambda, and Delta 13. Fluorescence in situ hybridization (FISH) analysis was done on clonal plasma cells (PCs) detected by immunofluorescence (cIg-FISH) of the cytoplasmic light chain. We also studied cells for @entity4910 and @entity2557 up-regulation by immunohistochemistry and immunofluorescence, respectively. Twenty-seven (46%) of 59 @entity1 had @entity7513 translocations, and 4 (11%) of 37 had an @entity19602 -lambda translocation. A t(11;14)(q13;q32) was found in 15 (25%) of 59 @entity1 , a t(4;14)(p16.3;q32) in 9% of @entity1 , and a t(14;16)(q32;q23) in 5% of @entity1 . All @entity1 with t(4;14)(p16.3;q32) tested (n = 3) had intense cytoplasmic fluorescence with an anti- @entity2557 antibody. PC nuclear staining of @entity4910 was only observed in @entity1 with t(11;14)(q13;q32); Delta 13 was detected in the clonal PCs in 50% of @entity1 . The percentage of abnormal PCs varied with any given abnormality. No obvious clinical or biologic correlations were associated with these @entity2008 . Similar translocations are found in both @entity8058 and @entity1582 , including t(4;14)(p16.3;q32) and t(14;16)(q32;q23). Moreover, Delta 13 is common in @entity8058 and unlikely to play a predominant role in the evolution of @entity8058 to @entity1582 .
