Amplification and overexpression of @entity1722 in XXXX of the salivary gland: correlation with poor prognosis.

@entity1 @entity135 @entity66 @entity3975 @entity5 @entity146 @entity189 @entity74 @entity1722
There are few reliable prognostic markers of biological @entity146 for @entity135 in general. For @entity189 , anatomic location, @entity5 size, histological grade, and extent of disease involvement are considered to be clinically important risk factors for recurrent disease. Molecular genetic alterations in @entity189 have not been characterized, and @entity5 cell proteins have not been shown to be prognostically significant. Here a cohort of @entity3975 of the major (parotid and submandibular) salivary glands are analyzed for a molecular @entity74 , @entity1722 gene amplification, and gene amplification and expression results are compared with long-term clinical follow-up information. Archival tissues resected from 58 @entity1 with @entity3975 of salivary glands were evaluated for @entity1722 gene amplification by fluorescence in situ hybridization and for gene expression by immunohistochemistry in a blinded fashion. Clinical follow-up information was compared with the results of these analyses to determine whether there were significant associations. Overexpression, identified as membrane immunostaining by immunohistochemistry, was observed in 22 of 58 (38%) @entity3975 . Gene amplification, characterized by fluorescence in situ hybridization, was observed in 12 (21%) cases. Eleven of the 12 cases with gene amplification were also immunostained for @entity1722 . Both gene amplification (P = 0.0001, P < 0.0001) and immunostaining (P < 0.0001, P < 0.0001) were correlated with @entity66 and poorer overall @entity1 survival, respectively. Multivariate analysis showed that @entity1722 immunostaining and amplification were markers of poor prognosis independent of histopathological grade, @entity5 size, and involvement of regional lymph nodes. @entity1722 is amplified and/or overexpressed in approximately one-third of @entity3975 of salivary glands. Amplification and/or overexpression appears to be an independent marker of poor prognosis in @entity3975 of the salivary glands as it is in @entity189 of the breast, ovary, and endometrium.
