Improvement in treatment and outcome of XXXX in north China.

@entity1 @entity788 @entity1124 @entity5 @entity3
BACKGROUND: The incidence of @entity788 has increased in China in the last decade, though efforts have been made in early detection and multimodality treatment. The aim of this study is to describe the decade-based development in early diagnosis and treatment modalities, as well as outcome for @entity1 with @entity1124 ( @entity1124 ) in a high-volume facility. METHODS: All the @entity1124 @entity1 underwent surgery between 1991 and 2009 and were selected from the database of TianJin @entity5 Institute and Hospital. Decade-based changes in early diagnosis, treatment modalities, and outcome of the @entity1 were retrospectively analyzed. RESULTS: Of the 565 @entity1 with @entity1124 , @entity1 in this decade (n   =   460) had better overall survival than those in the last decade (n   =   105), median survival was 10 months and 3 months, respectively. @entity1 in this decade had significantly improved in (P   <   0.001) 2-year (14.7%) and 5-year survival rates (3.5%) as compared to those in the last decade (6.7% and 3.4%, respectively). @entity1 with @entity3 at diagnosis in the last decade and this decade were 54% and 26% (P   <   0.001), respectively. More @entity1 in this decade had underwent R0/R1 resection (33% vs 20%, P   =   0.010), chemotherapy (37% vs 12%, P   <   0.001), and radical resection (34% vs 21%, P   =   0.014) than those in the last decade. CONCLUSION: @entity1 operated on for @entity1124 in this decade had a better outcome than those in the last decade. Early detection, improved resection margin, and development in multimodality treatment contribute to this improvement.
