XXXX of the duodenum is a distinct @entity706 : a retrospective study of 63 cases.

@entity1 @entity1944 @entity66 @entity706 @entity75 @entity5 @entity2225
PURPOSE: Small series with limited follow-up have suggested primary @entity706 of the duodenum (FL-D) to be an indolent disease. We report our experience on a large series of @entity1 followed for a median time period of longer than 6 years. @entity1 AND METHODS: The study comprised 63 @entity1 with primary FL-D defined as stage I disease. Endoscopy and detailed pathologic work-up was performed at diagnosis and at restaging to monitor the behavior of the @entity5 . RESULTS: Histologically, all 63 @entity1 had FL, low grade (1 to 2). @entity75 confined to mucosa/submucosa in 19 of 20 @entity1 . At an overall median follow-up of 77 months (range, 12 to 177 months), only two untreated @entity1 had developed @entity66 , the remaining 61 @entity1 never experienced extrasmall @entity1944 and large cell transformation did not occur at all. Among 24 @entity1 followed by watch and wait strategy, seven showed spontaneous complete regression and 17 had stable disease; radiotherapy resulted in complete regression in all 19 patients; anti- @entity2225 antibody monotherapy achieved complete regression in four @entity1 and stable disease in one @entity1 . Various chemotherapy protocols in eight @entity1 caused complete regression in all of them, but local relapses occurred in three. No @entity1 required surgery or died of disease. CONCLUSION: These findings characterize primary FL-D as a remarkably indolent FL variant, which, even left untreated, does not develop @entity5 growth, very rarely disseminates (two of 63 @entity1 ) and does not transform to high grade disease. A watch and wait approach appears to be the most sensible strategy.
