High expression of @entity2940 ( @entity2940 ) in a XXXX with cutaneous @entity404 -positive @entity706 .

@entity1 @entity404 @entity2940 @entity706 @entity5750 @entity146 @entity784 @entity2225 @entity3138 @entity4755 @entity4071 @entity4587 @entity405
@entity706 is a disease characterized with massive skin infiltration of lymphoid malignant cells. They commonly express some T-cell markers, such as @entity3138 , CD3, @entity404 , and @entity4587 , and thus termed as @entity784 ( @entity784 ). Here, we present a case with @entity2940 / @entity2940 -positive @entity706 , which appears lymphocytic morphology and expresses @entity404 , but does not express @entity3138 , CD3, @entity405 , @entity5750 , @entity4071 , @entity4755 , and @entity2225 . The most malignant cells contained no distinctive azurophilic granules in the cytoplasm. Southern blot analysis revealed that T cell receptor-beta, gamma, and immunoglobulin heavy chain genes in the cells were in germ-line configurations. Electron microscopic examination showed characteristics of lymphoid cells with higher nucleocytoplasmic ratio and lacked structures typical of other cell types (i.e., epithelial cells, neuroendocrine cells, and mesenchymal cells). Thus, the cells are likely to be immature lymphoid cells. Histological analysis revealed the cells infiltrate mainly into the dermis with angiocentric growth pattern. The clinical course was @entity146 , with rapid involvement of bone marrow and central nervous system. These striking features of the @entity1 may represent a novel fraction ( @entity3138 -, @entity404 +, and @entity2940 +) of @entity706 .
