Inflamma-miRs in Aging and XXXX : Are They Reliable Players?

@entity1 @entity32 @entity0 @entity66 @entity5
@entity1 aging is characterized by chronic low-grade @entity32 known as "inflammaging." Persistent low-level @entity32 also plays a key role in all stages of @entity0 since "inflammaging" is the potential link between @entity5 and aging through NF-kB pathways highly influenced by specific miRs. Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at a posttranscriptional level. Inflamma-miRs have been implicated in the regulation of immune and inflammatory responses. Their abnormal expression contributes to the chronic pro-inflammatory status documented in normal aging and major @entity66 ( @entity66 ), inflammaging being a significant mortality risk factor in both cases. Nevertheless, the correct diagnosis of inflammaging is difficult to make and its hidden contribution to negative health outcomes remains unknown. This methodological work flow was aimed at defining crucial unanswered questions about inflammaging that can be used to clarify aging-related miRNAs in serum and cell lines as well as their targets, thus confirming their role in aging and @entity0 . Moreover, we aim to highlight the links between the pro-inflammatory mechanism underlying the @entity5 and aging processes and the precise function of certain miRNAs in cellular senescence (CS). In addition, miRNAs and @entity5 genes represent the basis for new therapeutic findings indicating that both @entity5 and @entity66 genes are possible candidates involved in CS and vice versa. Our goal is to obtain a focused review that could facilitate future approaches in the investigation of the mechanisms by which miRNAs control the aging process by acting as efficient @entity66 inflammatory biomarkers. An understanding of the sources and modulation of inflamma-miRs along with the identification of their specific target genes could enhance their therapeutic potential.
