Therapeutic effects of a ketogenic diet in XXXX .

@entity1 @entity410 @entity2749 @entity3265 @entity6694 @entity1092 @entity1735 @entity412 @entity880 @entity302 @entity413 @entity2388
Seven @entity1 (age 5 to 10 years) with @entity6694 were investigated extensively. In 6 @entity1 elevations of blood @entity2388 were found. Blood @entity880 levels were marginally elevated. Two @entity1 had variably elevated blood @entity413 levels. Metabolic studies were otherwise normal apart from minimally elevated blood @entity3265 levels in 3 of 5 @entity1 tested, 2 of whom were on @entity1092 . All 7 patients had anticonvulsant resistant @entity410 . EEG changes included generalized slowing and multifocal spike wave discharges, and pseudo-periodic burst-suppression patterns during sleep. Respiratory monitoring revealed @entity2749 only during the waking record. Six @entity1 were below the 5th centile for weight despite normal caloric intake. Treatment with ketogenic diets, using medium chain @entity412 (MCT) oil when possible, has improved @entity410 control in the 5 @entity1 who could tolerate the diet. Slight behavioral and motor improvement has occurred in these 5 @entity1 and 6 of 7 @entity1 on high fat diets have gained weight. With a possible defect in @entity1735 metabolism and a @entity302 , use of a ketogenic diet is logical and appears to produce clinical benefit in @entity1 with Rett Syndrome.
