Lipid metabolism in pregnancy. VIII. Effects of dietary fat versus carbohydrate on lipoprotein and hepatic lipids and tissue XXXX lipases.

@entity2298 @entity52927 @entity1674 @entity969 @entity412 @entity35 @entity413 @entity165
We have asked, is @entity2298 in the fed state in pregnancy due to intolerance to exogenous fat, accumulation of endogenous @entity1674 , or accumulation of remnants of d < 1.006 lipoprotein metabolism? To answer these questions, we fed fat-free diets high in starch or @entity969 , or diets containing fat or fat plus @entity165 to pregnant and nonpregnant @entity35 for 12 days until gestational day 21 (term = 22 days). Blood was obtained 0, 4, or 8 hr after removal of food from the cages. Lipid concentrations were determined in chylomicrons and very low, low, and high density lipoproteins. @entity2298 in pregnancy exists on both starch and @entity969 containing fat-free diets and is exaggerated 4 and 8 hr after food is removed from the cage. The @entity412 rise occurs in d < 1.006 lipoproteins. With fat feeding, chylomicron @entity412 concentrations are not significantly elevated in pregnant @entity35 , 0 or 8 hr postabsorptively despite greater food intake in pregnancy. In contrast, very low density lipoprotein (VLDL) @entity412 concentrations are elevated at all times following fat feeding in pregnant compared to nonpregnant animals. A significant contribution of lipoprotein remnants to the @entity412 rise in d < 1.006 lipoproteins seems unlikely since an isolated increase in VLDL @entity165 is not observed. No statistically significant accumulation of hepatic @entity1674 occurs on any diet in pregnancy. Diet induced shifts in adipose tissue and muscle lipoprotein lipase activity are exaggerated in pregnancy while @entity52927 is unaffected. Fetal weight is similar on all diets except @entity969 where weight is reduced. CONCLUSIONS: @entity2298 in fed pregnant @entity35 is due to an increase in endogenous @entity1674 . Remnant lipid accumulation does not appear to contribute to the endogenous @entity2298 . There is no intolerance to exogenous (dietary) fat. The results are compatible with an unimpaired delivery of exogenous fat to fat oxidizing tissues thereby maximizing @entity413 availability for fetal growth.
