Leukocyte functions in 2 cases of XXXX .

@entity1 @entity5038 @entity73088 @entity281 @entity687 @entity6409
AIM: To investigate the r  le of leukocytes in the pathogenesis of @entity6409 ( @entity6409 ). METHODS: Peripheral blood polymorphonuclear neutrophils (PMNs), monocytes (MNs) and gingival crevicular fluid (GCF) were obtained from 2 cases of @entity6409 with typical features. The chemotaxis of PMNs and MNs were evaluated using a modified Boyden chamber. The adherence of PMNs was determined by adherence of PMNs to petri dishes. @entity687 ( @entity687 ) in GCF was detected by sandwich ELISA. Elastase activity in GCF was measured with a low molecular weight substrate ( @entity73088 ) specific for granulocyte elastase. RESULTS: PMNs from both @entity1 showed depressed chemotactic response to @entity5038 and @entity687 . Total amounts of @entity687 in GCF from the 2 @entity1 were much higher than those of the normal controls. Elastase activity was not significantly different from that of the controls. The adherence of PMN and the chemotaxis of MN in the 2 @entity1 were normal. CONCLUSION: The depressed chemotactic response of PMN leads to decreased recruitment of PMN and/or release of lysozyme from PMN in the diseased gingival tissue, increasing the susceptibility of @entity6409 @entity1 to periodontal @entity281 .
