Pretreatment swallowing assessment in @entity135 XXXX .

@entity1 @entity135 @entity5
OBJECTIVES/HYPOTHESIS: To discuss @entity1 variables associated with swallowing dysfunction in @entity135 ( @entity135 ) @entity1 prior to intervention. STUDY DESIGN: Prospective, multi-institutional cohort study. METHODS: All @entity1 included had newly diagnosed @entity135 . @entity1 undergoing instrumental swallowing evaluations prior to oncologic management were included for analysis. Pretreatment Penetration Aspiration Scores (PAS) were analyzed by @entity5 site, @entity5 stage, and standard demographic variables. RESULTS: The final study sample was comprised of 204 consecutive individuals with newly diagnosed @entity135 . @entity1 with advanced @entity5 ( @entity5 ) stage laryngeal/hypopharyngeal @entity5 had higher mean PAS scores (5.18) in contrast to early stage larynx/hypopharynx (1.93), advanced stage oral cavity/oropharynx (2.24), and early stage oral cavity/oropharynx (1.54, P < .0001), indicative of poorer function. Age, race, and sex were not associated with PAS scores. Multivariate logistic regression revealed significantly poorer PAS scores in @entity1 with advanced @entity5 (odds ration [OR] = 3.83, 95% confidence interval [CI], 1.84-8.00, P < .0001) and laryngeal/hypopharyngeal primary site disease (OR = 3.04, 95% CI, 1.41-6.54, P = .004), after controlling for all other variables. CONCLUSIONS: This series demonstrates that swallowing dysfunction in high-risk @entity1 may be present in the pretreatment state and should be considered when determining candidacy for organ preservation modalities. These data highlight the importance of instrumental swallowing evaluations prior to intervention, particularly for those individuals with advanced stage and/or laryngeal/hypopharyngeal @entity5 .
