Effects of subchronic administration of @entity4835 on acquisition of avoidance-escape behavior by XXXX .

@entity35 @entity4833 @entity4835
Holtzman male @entity35 were given four injections of saline or @entity4835 at 31 micrograms/kg or 46 micrograms/kg. The injections were given every 3 days during a 2-week period. Tail vein blood samples, drawn 24 hr before the first injection and 24 hr after the last injection, were analyzed for @entity4833 ( @entity4833 ) inhibition. For the low and high @entity4835 groups, whole blood @entity4833 was inhibited 20 and 24%, respectively, while plasma @entity4833 was inhibited 17 and 25%, respectively. Parallel saline injections produced a small inhibition of whole blood @entity4833 and an increase in activity (negative inhibition) of plasma @entity4833 . During the second week of @entity4835 administration @entity35 began training on a discriminated shock avoidance task. The seven animals administered 46 micrograms/kg @entity4835 did not learn the lever-pressing avoidance response during a period of 120 days. Five of eight saline @entity35 and four of seven 31 micrograms/kg @entity4835 @entity35 learned the avoidance response. There was no significant difference between learners relative to rate of learning of the avoidance task. All of the @entity35 learned to escape the shocks. These data indicate that subchronic @entity4835 inhibits learning of new behaviors by @entity35 .
