[Analysis of lymph node metastases of 217 cases of XXXX and its impact on prognosis].

@entity1 @entity5 @entity189 @entity418 @entity3
BACKGROUND _ OBJECTIVE: At present, the range of lymph node dissection in treatment of thoracic @entity418 is still controversial. This study was designed to explore the status of lymph node metastases of @entity418 and its influence on the prognosis and to seek reasonable dissecting range of lymph nodes. METHODS: A retrospective study was performed on the clinical data of 217 @entity1 who had underwent radical operation through three-field lymphadenectomy. Nine distinguishing clinicopathological factors possibly influencing survival rate were chosen. A multivariate analysis of these factors was performed by the computerized Cox proportional hazards model. RESULTS: The 1-, 3-, and 5-year survival rates of all @entity1 were 82.6%, 59.8%, and 48.8%, respectively. The lymph node @entity3 rate was 62.6% and the leaping @entity3 rate of lymph nodes was 5.5%. In 3989 lymph nodes dissected, metastases were detected in 454 (11.38%). The lymph node @entity3 rates present in neck, thoracic mediastinum, and abdominal cavity were 31.7%, 21.2%, and 12.1% in @entity418 , 21.9%, 30.5%, and 15.6% in @entity189 , 9.75%, 12.7%, and 34.5% in @entity189 , respectively. Degree of @entity5 differentiation, depth of @entity5 invasion, and lymphatic vessels invasion were the factors influencing lymph nodes metastases, but the length of @entity5 was not. According to multivariate analysis, depth of @entity5 invasion, @entity5 differentiation, the number of lymph nodes metastatic field, and @entity5 location were of prognostic significance. With the increasing of the number of lymph nodes metastatic field, the survival rate of the @entity1 dropped gradually(P = 0.0284). CONCLUSION: Lymph node @entity3 especially the number of lymph node metastatic field is one of key factors affecting the prognosis of @entity1 . Because of the upward, downward, and leaping spreading of @entity418 cells to the lymph nodes, the @entity1 with @entity418 should be given radical operation through three-field lymphadenectomy to promote the 5-years survival rate.
