XXXX is associated with an increased risk of @entity263 recurrence after prostatectomy in the PSA era.

@entity1 @entity1017 @entity263 @entity28
Although @entity28 at the time of prostatectomy has been associated with @entity263 recurrence, it is unknown whether @entity28 before or after surgery, or weight change from the years prior to surgery to after surgery is associated with recurrence. Thus, we examined the influence of @entity28 and weight change on recurrence after prostatectomy. We conducted a retrospective cohort study of 1,337 @entity1 with clinically localized @entity263 who underwent prostatectomy performed during 1993-2006 by the same surgeon. @entity1 self-reported weight and physical activity at 5 years before and 1 year after surgery on a survey during follow-up. Mean follow-up was 7.3 years. We estimated multivariable-adjusted HRs of @entity263 recurrence comparing @entity28 at 5 years before and at 1 year after surgery with normal weight, and a gain of more than 2.2 kg from 5 years before to 1 year after surgery with stable weight. During 9,797 @entity1 years of follow-up, 102 @entity1 recurred. Compared with @entity1 who had stable weight, those whose weight increased by more than 2.2 kg had twice the recurrence risk (HR = 1.94; 95% CI, 1.14-3.32) after taking into account age, pathologic stage and grade, and other characteristics. The HR of recurrence was 1.20 (95% CI, 0.64-2.23) and 1.72 (95% CI, 0.94-3.14) comparing @entity28 at 5 years before and at 1 year after surgery, respectively, with normal weight. Physical activity (>=  5 h/wk) did not attenuate risk in @entity1 who gained more than 2.2 kg. By avoiding @entity1017 , @entity1 with @entity263 may both prevent recurrence and improve overall well-being.
