Control of regional @entity3 after induction chemotherapy and radiotherapy for XXXX .

@entity1 @entity900 @entity1259 @entity189 @entity177 @entity3
BACKGROUND: To study the impact of adding induction chemotherapy to radiotherapy on the long-term control of regional @entity3 and survival in @entity1 with @entity189 ( @entity189 ). METHODS: Between February 1988 and August 1993, 240 @entity189 @entity1 with Ho's T3 stage, N2-3 stage, or nodal size >/=3 cm were recruited onto two randomized trials comparing induction chemotherapy followed by radiotherapy (CT + RT) and radiotherapy alone (RT) using a similar treatment protocol. Of these, 210 @entity1 (105 in each treatment arm) had cervical nodal @entity3 and were included in the analysis. @entity1 in the CT + RT arm received two to three cycles of @entity900 , 60 mg/m(2) day 1, + @entity1259 , 110 mg/m(2) day 1, followed by radiotherapy. Radiotherapy technique and dose were similar in both arms. The median follow-up time was 71 months (range, 5-152 months). RESULTS: The overall response rate of nodal disease to chemotherapy was 86%, and the complete response (CR) rate was 44%. At the end of radiotherapy, 92% of @entity1 in the CT + RT arm and 86% in the RT arm achieved CR in the neck (p =.12). The 5-year nodal relapse-free survival rates in the CT + RT and RT arm were 83% and 75%, respectively (p =.13). @entity177 (81%) occurred during the first 36 months of follow-up. Radical neck dissection successfully salvaged 41% of neck failures in the CT + RT arm and 46% in the RT arm. The 5-year distant metastases-free survival rates were 70% in the CT + RT arm and 68% in the RT arm (p =.56), and the corresponding 5-year disease-specific survival rates were 66% and 68%, respectively (p =.55). In subgroup analysis, no significant differences in regional control and survival could be found in @entity1 with Ho's N2-3 stage, AJCC N2-3 stage, or nodal size >6 cm. CONCLUSIONS: Induction chemotherapy does not seem to improve the regional control and survival in @entity189 @entity1 with regional @entity3 compared with radiotherapy alone and is not recommended as a routine treatment outside the context of a clinical trial.
