Body fat percentage is associated with XXXX in BMI-defined normal weight subjects.

@entity1 @entity101 @entity28 @entity66 @entity10204 @entity854 @entity412 @entity413 @entity165
BACKGROUND AND AIMS: Nearly 25% of normal weight individuals display abnormal metabolic profiles associated with @entity28 . As a wide range in body fat percentage (%BF) exists for BMI-defined normal weight individuals, we investigated whether elevated %BF (determined using DXA) was associated with @entity10204 among 977 normal weight subjects (192 @entity1 , 785 @entity1 ) from the Canadian province of Newfoundland and Labrador. METHODS AND RESULTS: BMI and %BF were measured after a 12-h fasting period. @entity854 considered included elevated @entity412 , @entity413 and hsCRP levels, decreased HDL @entity165 , insulin resistance, and @entity101 . Subjects were classified as metabolically healthy (0 or 1 @entity854 ) or abnormal (>= 2 @entity854 ) and divided into sex-specific %BF tertiles as follows: low ( <=15.2% @entity1 ,  <=29.7% @entity1 ), medium (15.3-20.7%% @entity1 , 29.8-34.9%% @entity1 ) and high (>= 20.8% @entity1 , >= 35.0% @entity1 ). The prevalence of the metabolically abnormal phenotype was higher among medium and high %BF subjects (12.0% and 19.5%, respectively) compared to the low group (7.4%; p  <  0.05). Furthermore, the odds of being metabolically abnormal were 1.61 (95% CI 0.94-2.77) for medium %BF subjects compared to the low group and nearly tripled for high %BF subjects (OR 2.73, 95% CI 1.63-4.86). ORs remained significant after further adjustment for waist circumference. CONCLUSION: Our findings indicate that those with elevated %BF are at increased risk of developing @entity66 despite having a normal BMI. Future development of adequate screening tools to identify these individuals is crucial to the prevention of @entity28 .
