XXXX gene in high functioning @entity2438 : no association according to family and meta-analysis approaches.

@entity1 @entity2198 @entity72476 @entity245 @entity2438 @entity72477 @entity72 @entity32274
UNASSIGNED: The @entity32274 ( @entity32274 ) gene has been discussed to be associated with different symptoms of @entity72 ( @entity72 ) and other @entity245 . We aimed to elucidate the genetic association of @entity32274 within @entity2198 ( @entity2198 ), focusing on @entity2438 specific symptoms and reducing intelligence related factors. Furthermore, we compared our findings conducting a meta-analysis in @entity1 with @entity2438 and @entity2198 only. A case-control association study was performed for @entity2198 ( @entity2198 , n  =  105; controls, n  =  133). Moreover, we performed a family-based association study (DFAM) analysis ( @entity2198 , n  =  44; siblings, n  =  57). Individuals were genotyped for the two most frequently reported single nucleotide polymorphisms (SNPs) in the @entity32274 gene ( @entity72476 , @entity72477 ). Furthermore, a meta-analysis using the MIX2 software integrated our results with previously published data. A significant association for the carriers of the T-allele of the @entity72477 with @entity2198 was found in the case-control sample [OR  =  1.547; (95  % CI 1.056-2.266); p  =  0.025]. No association could be found by DFAM with any of the @entity32274 SNPs with @entity2198 . The meta-analysis of both SNPs did not show a significant association with either @entity2438 or with @entity2198 . Overall, including case-control, sibs, and meta-analysis, we could not detect any significant association with the @entity32274 gene and @entity2198 . Our results point in the direction that @entity32274 may not play a major role in @entity2198 , but rather seems to have a significance in @entity245 or in individuals displaying @entity245 .
