XXXX Causes Cell Death in Neural Progenitor Cells and Impairs Adult Hippocampal Neurogenesis.

@entity9140 @entity14625 @entity6 @entity19 @entity25242 @entity179 @entity1889 @entity204 @entity528
UNASSIGNED: @entity14625 (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and @entity1889 catabolism, and its accumulation is associated with various @entity179 , such as @entity6 and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocampal neurons. However, these effects have not been studied in the context of neurogenesis. Here, we report that MG adversely affects hippocampal neurogenesis and induces neural progenitor cell (NPC) @entity204 . MG significantly reduced C17.2 NPC proliferation, and high concentration of MG (500   M) induced cell @entity204 and elevated oxidative stress. Further, MG was found to activate the ERK signaling pathway, indicating elevated stress response. To determine the effects of MG in vivo, @entity19 were administrated with vehicle or MG (0.5 or 1  % in drinking water) for 4  weeks. The numbers of BrdU-positive cells in hippocampi were significantly lower in MG-treated @entity19 , indicating impaired neurogenesis, but MG did not induce @entity528 or glial activations. Interestingly, MG reduced memory retention when administered to @entity19 at 1  % but not at 0.5  %. In addition, the levels of hippocampal @entity9140 and @entity25242 were significantly lower in the hippocampi of @entity19 treated with MG at 1  %. Collectively, our findings suggest MG could be harmful to NPCs and to hippocampal neurogenesis.
