Calretinin expression in XXXX of adipose tissue.

@entity808 @entity242 @entity5 @entity362 @entity2615 @entity1822 @entity980 @entity1821
Although well established as a marker of mesothelial cells, calretinin is also expressed in several other tissue types, including adipose tissue. Accordingly, immunohistochemical staining for calretinin has been described in an increasing number of @entity5 other than @entity2615 . A detailed analysis of calretinin expression in lipogenic @entity5 has not yet been reported, however. Given the known expression patterns of calretinin in normal tissues, we predicted that calretinin immunoreactivity would be detected in @entity362 and the various histologic subtypes of @entity1821 , and that this marker might be of use in the differential diagnosis of selected @entity362 . A variety of pleomorphic and small round cell @entity242 were studied for comparison. Calretinin immunoreactivity was detected, at least focally, in all 10 samples of normal adipose tissue and in 22 of 23 @entity362 or @entity362 variants. Staining for calretinin was also positive within the lipogenic component of 28 of 29 @entity1821 variants. Of the 7 dedifferentiated @entity1821 , 3 were focally positive for calretinin. Pleomorphic variants of other @entity242 , including undifferentiated high-grade @entity242 , @entity980 , @entity1822 , and @entity808 also exhibited focal calretinin immunoreactivity in a minority of cases, as did some small round cell @entity242 . These results suggest that calretinin immunoreactivity in normal and neoplastic adipose tissue is more ubiquitous than previously reported and may be a useful, albeit nonspecific marker of lipogenic differentiation. However, its utility in the differential diagnosis of @entity362 appears limited.
