XXXX and paranasal sinuses.

@entity1 @entity4153 @entity146 @entity5 @entity1179 @entity6881 @entity420 @entity3270
INTRODUCTION: @entity4153 ( @entity4153 ) of the sinonasal tract is a rare disease. OBJECTIVE: Report a descriptive study of a relatively large cohort of @entity4153 of the nasal cavity and paranasal sinuses. METHOD: The medical records of 21 @entity1 presenting with nasal and paranasal @entity4153 to various French hospitals, from 1989 to 2003, were analysed to determine the clinical features and current treatment of the disease. RESULTS: @entity1 data were obtained from eight French hospitals. Twelve of the @entity1 were male and nine were female, with a mean age at presentation of 55 years (range: 27 to 79 years). @entity1 ' staging for nasal cavity malignancy was: T1, four; T2, three; T3, one; T4, 13; N0, 18; N2, three; M0, 20; and M1, one. None of the @entity1 suffered from @entity4153 of the sinonasal tract with ectopic hormone production. Immunohistochemistry proved useful for diagnosis in 20 cases. Twelve cases were positive for @entity6881 for chromogranin, eight for neuron-specific enolase and 11 for neuron-specific synaptophysin. One @entity1 had an @entity420 and an @entity1179 associated with @entity3270 . @entity1 underwent surgery (11 cases), radiotherapy (14 cases) and chemotherapy (12 cases). Recurrence occurred in 10 cases. Five @entity1 had visceral metastases or cervical lymph node involvement. Nine of the @entity1 died within four years of onset of the disease. CONCLUSION: @entity4153 of the sinonasal tract is an uncommon @entity5 with @entity146 clinical behaviour. Recurrence is frequent and the prognosis is poor. However, the current treatment of these neuroendocrine @entity5 varies widely.
