DNA and S-phase representation in XXXX @entity2124 producing @entity977 .

@entity1 @entity2007 @entity5 @entity2124 @entity2012 @entity977
The DNA contents of 33 @entity977 from @entity1 with @entity2012 were analysed with flow-cytofluorometry. Degrees of ploidy and the proliferation rate, expressed as percentage of cells in S-phase, were determined. The aim was to compare these morphological and functional @entity5 properties with clinical and laboratory parameters to establish a possible relation and to further elucidate the characteristics of these @entity5 . In 15 @entity5 (45%) diploid DNA pattern were found, while 18 (55%) showed varying degrees of @entity2007 . The frequency of cells in S-phase showed wide variations and were equally distributed in diploid and @entity5 . Duration of symptoms, age at diagnosis, preoperative @entity2124 ( @entity2124 )- and prolactin (Prl)-levels, @entity5 size and grade of invasive @entity5 growth as determined by radiological estimations, did not correlate to ploidy or grade of proliferation. The lack of correlation between DNA pattern and proliferation rate in relation to clinical, laboratory and radiological parameters in @entity5 causing @entity2012 contrasts to the documented relation between the degree of ploidy, cells in proliferation and grade of @entity5 reported in @entity5 of other sites. The 55% aneuploid @entity2124 producing @entity5 indicate a certain malignant transformation. The high frequency of cells in S-phase in several @entity2124 secreting @entity5 completes the malignant morphological and functional cell properties. The benign character of @entity5 causing @entity2012 is therefore in contrast to these findings. The lack of clinical significance of the DNA pattern and the frequency of cells in proliferation in @entity2124 producing @entity5 and the benign character despite malignant cell properties in most of these @entity5 are difficult to explain.(ABSTRACT TRUNCATED AT 250 WORDS)
