Autoantibodies to neuronal surface antigens in thyroid antibody-positive and -negative XXXX .

@entity1 @entity1024 @entity198 @entity75 @entity5 @entity14752 @entity972 @entity792 @entity14204
BACKGROUND: Thyroid antibodies (Thy-Abs) are frequently detected in various @entity792 in coexistence with other systemic autoantibodies. In association with an @entity75 , they are often taken as evidence of @entity14752 ( @entity14752 ). However, the presence of Thy-Abs in a cohort of @entity14204 ( @entity14204 ) @entity1 and their association with anti-neuronal autoimmunity has not been explored. @entity1 AND METHODS: We investigated thyroid and anti-neuronal antibodies in the sera of 24 @entity14204 @entity1 without identified @entity5 by cell-based assay and radioimmunoassay and evaluated their clinical features. RESULTS: There was a female predominance in Thy-Ab-positive @entity14204 @entity1 . Five of the eight Thy-Ab-positive @entity1 and six of the 16 Thy-Ab-negative patients had antibodies to voltage-gated @entity972 channel (VGKC), @entity1024 receptor (NMDAR) or undefined surface antigens on cultured hippocampal neurons. There were trends towards fewer VGKC antibodies (1/8 vs. 5/16, P = 0.159) and more NMDAR antibodies (2/8 vs. 1/16, P = 0.095) among the Thy-Ab-positive @entity14204 patients; antibodies to undefined surface antigens were only identified in Thy-Ab-positive @entity1 (2/8 vs. 0/16, P = 0.018). There were no distinguishing clinical features between Thy-Ab-positive @entity1 with and without neuronal antibodies. However, patients with anti-neuronal antibodies showed a better treatment response. CONCLUSION: Thy-Abs can be found in a high proportion of @entity1 with non-paraneoplastic @entity14204 , often in association with antibodies to specific or as yet undefined neuronal surface antigens. These results suggest that acute idiopathic @entity198 @entity1 with Thy-Abs should be closely monitored for ion-channel antibodies and it should not be assumed that they have @entity14752 .
