Ferrous-salt-promoted damage to @entity39531 and @entity10555 . The increased effectiveness of XXXX -radical scavengers in the presence of @entity1098 .

@entity3884 @entity68 @entity1098 @entity3787 @entity39531 @entity2145 @entity10555
@entity3787 radicals ( @entity2145 .) in free solution react with scavengers at rates predictable from their known second-order rate constants. However, when @entity2145 . radicals are produced in biological systems by metal-ion-dependent Fenton-type reactions scavengers do not always appear to conform to these established rate constants. The detector molecules @entity39531 and @entity10555 were used to study damage by @entity2145 . involving a @entity3884 -abstraction reaction and an aromatic hydroxylation. In the presence of @entity1098 the rate constant for the reaction of scavengers with @entity2145 . was generally higher than in the absence of @entity1098 . This radiomimetic effect of @entity1098 can be explained by the removal of @entity68 from the detector molecule, where it brings about a site-specific reaction, by @entity1098 allowing more @entity2145 . radicals to escape into free solution to react with added scavengers. The @entity39531 assay, although chemically complex, in the presence of @entity1098 appears to give a simple and cheap method of obtaining rate constants for @entity2145 . reactions that compare well with those obtained by using pulse radiolysis.
