Fatal @entity296 and XXXX associated with complement activation induced by plasma infusion in severe porcine @entity295 .

@entity1707 @entity295 @entity296 @entity1508 @entity39 @entity5 @entity1457 @entity3652 @entity460 @entity526
We have previously reported that fresh frozen plasma (FFP) may induce a rapid irreversible shock when repeatedly infused in @entity1707 challenged with Gram-negative @entity295 . The aims of the present study were to elucidate the cardiovascular nature of the shock and determine the aetiologic role of @entity5 @entity39 factor (TNF), complement activation and @entity1508 anaesthesia. Three groups of anaesthetized piglets were inoculated with a lethal dose of live @entity526 bacteria. Groups I (n = 8) and III (n = 8) were anaesthetized with @entity1508 and group II (n = 8) with @entity3652 . Animals in groups I and II received repeated infusions of FFP, whereas animals in group III received repeated infusions of 7% albumin. Six animals in group I and four animals in group II died during the first plasma infusion. Survival time was significantly longer in group II (P = 0.04) compared to group I. No animals in group III died during the albumin infusions, and no adverse effects were observed during the infusions. In group I the plasma induced shock was characterized by abruptly falling mean arterial pressure, cardiac index, systemic vascular resistance index and left ventricular contractility. Concomitant increases were recorded in left ventricular filling pressure and central venous pressure. Group II demonstrated a similar, but delayed response. Plasma infusion was associated with a significant increase in terminal complement complex (TCC) (P < 0.03 in group I, P < 0.05 in group II) and depletion of serum ionized @entity460 . We conclude that FFP may induce fatal @entity296 and @entity1457 in severe @entity295 . Complement activation may be of aetiologic importance.
