Prolonged XXXX duration from prodromal onset predicts outcome in first @entity914 .

@entity1 @entity914 @entity51 @entity161 @entity716 @entity2414 @entity221
Several, although not all, studies suggest that prolonged duration of @entity221 (DUI) predicts poor outcome in @entity914 such as @entity161 . It is unclear whether this association can be explained by factors such as @entity51 or poor premorbid adjustment. First @entity716 @entity1 were evaluated at 1 and 2 years following baseline evaluations. Predictive measures showing significant correlations with outcome were entered in multiple regression analyses with Strauss-Carpenter scale (SC) and Global Assessment of Functioning scale (GAF) outcome scores as dependent variables. Illness duration computed from the onset of the prodrome (DUI-pro), used both as a dichotomous and as a continuous measure, highly significantly predicted both GAF and SC scores at 2 years. On the other hand, baseline functioning significantly predicted the 1-year but not the 2-year outcome. When Premorbid Adjustment Scale (PAS) scores were additionally entered into the analyses in a smaller subset, the relation between DUI-pro and the 2-year outcome scores remained significant. Significant associations were also seen between outcome and baseline neuropsychological @entity2414 . Further research is needed to examine whether prolonged @entity221 is simply associated with poor outcome or plays a causal role in relation to outcome. The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early @entity716 phases of @entity161 .
