[The clinical and muscular pathological features of statin-induced XXXX ].

@entity1 @entity2125 @entity5442 @entity1560 @entity39 @entity908 @entity16 @entity4 @entity194 @entity925 @entity121 @entity6817
OBJECTIVE: To explore clinical and muscular pathological features of statin-induced @entity121 . METHODS: Nine @entity1 were enrolled in this study, who were diagnosed as statin-induced @entity121 by muscle biopsy in Peking University First Hospital from April, 2012 to October, 2014. The clinical data and pathological findings were analyzed. RESULTS: The exposure time to statins varied from 4 days to 4 years in the total of 9 @entity1 , 6 males and 3 females, with the average age of 63    6 (55 to 74) years old. Three @entity1 suffered from @entity925 and 6 @entity1 complained of weakness mainly at the proximal limbs, while no symptoms occured in 3 patients. Serum @entity908 kinase (CK) increased in all @entity1 with the maximum value varied from 468 to 8 000 U/L. Serum @entity5442 antibodies were tested in 7 @entity1 and all were negative. Electromyogram was performed in six @entity1 with @entity16 found in 2 @entity1 . MRI of bilateral thigh muscle was carried out in six @entity1 with @entity4 and mild @entity1560 found in 2 @entity1 . All @entity1 underwent skeletal muscle biopsy with histochemical and immunohistochemical staining. The main muscular pathological features were muscle fiber @entity194 , @entity39 , regeneration and increased lipid droplets. Ragged blue fiber, cytochrome C oxidase-negative muscle fibers and decreased @entity2125 activity were observed in some @entity1 . MHC-I expressed in the sarcolemma of muscle fibers at various levels. Mild C5b-9 staining was found in the endomysium, capillary and cytoplasm. Symptoms and the level of CK were improved in 7 @entity1 after discontinuing @entity6817 or changing to another statin, while the immunosuppressive therapy were used in 2 @entity1 and shown to be effective. CONCLUSIONS: @entity6817 induced @entity121 is self-limiting in most @entity1 , with improvement after discontinuation of statins. Few @entity1 with @entity39 need immunosuppressive therapy.
