The Effect of Changes in @entity410 and Weight on Obstructive Sleep Apnea Severity in Overweight Adults with Type 2 XXXX .

@entity1 @entity410 @entity6 @entity27 @entity209
STUDY OBJECTIVES: To examine the effect of changes in @entity27 ( @entity27 ) severity prior to and following adjustment for changes in weight over the course of a 4-y weight loss intervention. DESIGN: Prospective analysis of baseline, 1- and 4-y follow-up data from a randomized controlled trial. SETTING: Four Look AHEAD clinical centers. @entity1 : Two hundred sixty-three overweight/obese adults with type 2 @entity6 and @entity27 . INTERVENTIONS: Intensive lifestyle intervention or education control condition. MEASUREMENTS: Change in the @entity27 ( @entity27 ) served as the primary outcome. The percentage change in @entity410 (submaximal @entity209 ( @entity209 )) and change in weight (kg) were the primary independent variables. Primary analyses collapsed intervention conditions with statistical adjustment for treatment group and baseline @entity209 , weight, and @entity27 among other relevant covariates. RESULTS: At baseline, greater @entity209 were associated with lower @entity27 (B(SE) = -1.48(0.71), P = 0.038), but this relationship no longer existed (B(SE) = -0.24(0.73), P = 0.75) after adjustment for weight (B(SE) = 0.31(0.07), P < 0.0001). Fitness significantly increased at year 1 (+16.53    28.71% relative to baseline), but returned to near-baseline levels by year 4 (+1.81    24.48%). In mixed-model analyses of @entity27 change over time without consideration of weight change, increased @entity410 at year 1 (B(SE) = -0.15(0.04), P < 0.0001), but not at year 4 (B(SE) = 0.04(0.05), P = 0.48), was associated with @entity27 . However, with weight change in the model, greater weight loss was associated with @entity27 at years 1 and 4 (B(SE) = 0.81(0.16) and 0.60(0.16), both P < 0.0001), rendering the association between @entity410 and @entity27 change at year 1 nonsignificant (B(SE) = -0.04(0.04), P = 0.31). CONCLUSIONS: Among overweight/obese adults with type 2 @entity6 , @entity410 change did not influence @entity27 severity change when weight change was taken into account. TRIAL REGISTRATION: ClinicalTrials.gov identification number NCT00194259.
