Down-regulation of microRNA-124 is correlated with @entity5 metastasis and poor prognosis in XXXX with @entity2 .

@entity1 @entity5 @entity1149 @entity2 @entity1349
INTRODUCTION: MicroRNA-124 (miR-124) has been proven dysregulated in several @entity1 @entity5 and correlated with @entity5 progression. However, its expression and clinical significance in @entity1149 ( @entity1149 ) is still unclear. Thus, the aim of this study was to investigate the clinical significance of miR-124 expression in @entity1149 . METHODS: Expression levels of miR-124 in 92 pairs of @entity1149 and adjacent non- @entity5 tissues were detected by quantitative real-time PCR (qRT-PCR). In order to determine its prognostic value, overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis. RESULTS: miR-124 expression level was significantly lower in @entity1149 tissues compared with adjacent non- @entity5 tissues (P < 0.05). The 5-year OS of low miR-124 expression group was significantly shorter than that of high miR-124 expression group (P < 0.05). Moreover, the 5-year DFS of low miR-124 expression group was also significantly shorter than that of high miR-124 expression group (P < 0.05). In a multivariate Cox model, we found that miR-124 expression was an independent prognostic factor for both 5-year OS and 5-year DFS in @entity1149 (P < 0.05). CONCLUSIONS: Our results offer the convincing evidence that miR-124 may play key roles in the progression of @entity2 and that the down-regulated expression of miR-124 may be independently associated with @entity1349 and DFS of @entity1 , suggesting that miR-124 might be a potential marker for further risk stratification in the treatment of @entity2 .
