The XXXX independent flow is reduced in the transplanted liver.

@entity1 @entity205 @entity6741 @entity970 @entity968 @entity10055
Bile secretion is an important indicator of liver graft function. Reports on bile formation by the transplanted liver with stable function some months after operation are scarce. In this study bile flow, @entity6741 secretion rate (BSSR) and biliary clearance of @entity968 ( @entity970 ) 900, a marker of canalicular bile flow, were studied in a group of liver-transplanted (LTX) @entity1 (n = 8) 3-6 months after transplantation. A group of cholecystectomized @entity1 with indwelling T-tubes (n = 6) served as a control group. Both groups were treated with oral @entity10055 (500 mg/day). On the day of the study bile was drained for 6 h by gravity and four-hourly samples were used in the calculations. The relation between bile flow and BSSR analysed with linear regression showed a reduced @entity6741 independent flow in the liver-transplanted group (0.11 ml/min) compared with the control group (0.20 ml/min). The relation between biliary clearance of @entity970 900 and BSSR showed a significantly steeper slope for the cholecystectomized control @entity1 (1.40 ml/micromol) compared with the liver-transplanted @entity1 (0.30 ml/micromol). We conclude, that in spite of stable graft function with normal liver enzmyes, the transplanted liver has a reduced @entity6741 independent bile flow. The transplanted liver also has a reduced biliary clearance of @entity970 900 indicating a reduced canalicular bile flow. The cause of this impaired bile formation could be due to the influence of the immunosuppressive drug @entity205 , the result of damage to the liver during preservation and reperfusion or the continuous immunological challenge to the graft.
