Relationship between fibroblastic foci profusion and high resolution CT morphology in XXXX .

@entity1 @entity2415 @entity2416 @entity358 @entity56 @entity4595 @entity401
BACKGROUND: Fibroblastic foci profusion on histopathology and severity of traction @entity4595 on highresolution computed tomography (HRCT) have been shown to be predictors of mortality in @entity1 with @entity2416 ( @entity2416 ). The aim of this study was to investigate the relationship between fibroblastic foci (FF) profusion and HRCT patterns in @entity1 with a histopathologic diagnosis of @entity2416 ( @entity2416 ), fibrotic @entity401 ( @entity401 ) and @entity56 ( @entity56 ). METHODS: The HRCT scans of 162 @entity1 with a histopathologic diagnosis of @entity2416 or @entity401 (n   =   162) were scored on extent of groundglass opacification, reticulation, honeycombing, @entity2415 and severity of traction @entity4595 . For each @entity1 , a fibroblastic foci profusion score based on histopathologic appearances was assigned. Relationships between extent of fibroblastic foci and individual HRCT patterns were investigated using univariate correlation analysis and multivariate linear regression. RESULTS: Increasing extent of reticulation (P   <   0.0001) and increasing severity of traction @entity4595 (P   <   0.0001) were independently associated with increasing FF score within the entire cohort. Within individual multidisciplinary team diagnosis subgroups, the only significant independent association with FF score was severity of traction @entity4595 in @entity1 with @entity2416 ( @entity2416 )/ @entity2416 (n   =   66, r(2)   =   0.19, P   <   0.0001) and @entity1 with @entity56 ( @entity56 ) (n   =   49, r(2)   =   0.45, P   <   0.0001). Furthermore, FF score had the strongest association with severity of traction @entity4595 in @entity1 with @entity2416 (r(2)   =   0.34, P   <   0.0001) and @entity56 (r(2)   =   0.35, P   <   0.0001). There was no correlation between FF score and severity of traction @entity4595 in @entity1 with @entity401 . Global disease extent had the strongest association with severity of traction @entity4595 in @entity1 with @entity401 (r(2)   =   0.58, P   <   0.0001). CONCLUSION: In @entity1 with @entity358 , profusion of fibroblastic foci is strikingly related to the severity of traction @entity4595 , particularly in @entity2416 and @entity56 . This may explain the growing evidence that traction @entity4595 is a predictor of mortality in several @entity358 .
