Treatment of asphyxiated newborns with moderate XXXX in routine clinical practice: how cooling is managed in the UK outside a clinical trial.

@entity1 @entity558 @entity75 @entity519 @entity1763 @entity2332
BACKGROUND: This is a phase 4 study of @entity1 registered with the UK TOBY Cooling Register from December 2006 to February 2008. The registry was established on completion of enrolLment to the TOBY randomised trial of treatment with whole body @entity2332 following perinatal @entity1763 at the end of November 2006. METHODS: We collected information about @entity1 characteristics, @entity558 at birth, resuscitation details, severity of @entity75 , hourly temperature record, clinical complications and outcomes before hospital discharge. RESULTS: 120 @entity1 born at a median of 40 (IQR 38-41) weeks' gestation and weighing a median of 3287 (IQR 2895-3710) g at birth were studied. Cooling was started at a median of 3 h 54 min (IQR 2 h-5 h 32 min) after birth. All but three @entity1 underwent whole body cooling. The mean (SD) rectal temperature from 6 to 72 h of the cooling period was 33.57 degrees C (0.51 degrees C). The daily @entity75 score fell: median (IQR) 11 (6-15), 9.7 (5-14), 8 (5-13) and 7 (2-12) on days 1-4 after birth, respectively. 51% of the @entity1 established full oral feeding at a median (range) of 9 (4-24) days. 26% of the study @entity1 died. MRI was consistent with @entity519 -ischaemia in most cases. Clinical complications were not considered to be due to @entity2332 . CONCLUSION: In the UK, therapeutic @entity2332 following perinatal @entity1763 is increasingly being provided. The target body temperature is successfully achieved and the clinical complications observed were not attributed to @entity2332 . Treatment with @entity2332 may have prevented the worsening of the @entity75 that is commonly observed following @entity1763 .
