@entity189 arising in XXXX of the pancreas: a matched control study with conventional @entity1124 .

@entity1 @entity788 @entity4929 @entity3079 @entity1124 @entity189 @entity30946 @entity420
OBJECTIVE: The purpose of this study was to characterize the clinicopathological features of invasive @entity189 arising in @entity4929 of the pancreas (IPMN) by histological subtype of the invasive component and to compare the outcomes of these @entity1 to a cohort of matched @entity1 with conventional ductal @entity788 . BACKGROUND: Two distinct histological subtypes of invasive @entity189 arising in IPMNs have been described, @entity3079 and @entity420 . Previous reports have suggested prognostic differences between these 2 subtypes but a matched comparison of @entity3079 , @entity420 , and conventional @entity788 has not been reported. METHODS: The clinicopathological variables of 59 @entity1 resected for an invasive component of IPMN were analyzed with detailed pathologic review of histopathologic subtype ( @entity3079 and @entity420 ). Using a postresection @entity788 nomogram, @entity1 with either @entity420 were matched on a 1:1 basis with @entity1 resected for conventional ductal @entity788 . Clinicopathological factors and overall outcome was analyzed between the matched groups. RESULTS: Fifty-nine @entity1 underwent resection for IPMN with an associated @entity189 ( @entity30946 ). The estimated 3- and 5-year survival rates were 76% and 68%, respectively. @entity420 was present in 35 @entity1 (59%) and 24 @entity1 (41%) had @entity3079 . @entity420 subtype [hazard ratio (HR) 3.7, 95% confidence interval (CI) 1.2-11.6] and the presence of positive regional lymph nodes (HR 3.2 95% CI 1.2-8.2) were clinicopathological factors predictive of decreased survival by multivariate analysis. The 5-year estimated survival rates for @entity420 and @entity3079 were 55% and 87%, respectively (P = 0.01). When compared with @entity1 with @entity1124 resected during the same time period matched by a prognostic nomogram, @entity1 with @entity3079 had a significantly longer survival outcome compared with @entity1 with conventional @entity420 (P = 0.0001). By contrast, survival after resection between @entity1 with the tubular subtype (3-year estimated survival, 61%) and the matched group with conventional @entity420 (3-year estimated survival, 21%) (P = 0.87) was not statistically different. CONCLUSIONS: In this study, the @entity3079 histological subtype of invasive IPMN had a more statistically favorable survival outcome than the tubular subtype. @entity1 with invasive tubular IPMN had no statistically significant difference in survival as matched @entity1 with @entity1124 .
