The regulation of luteinizing hormone secretion by @entity172 : relationships among negative feedback, surge potential, and male stimulation in juvenile, peripubertal, and adult female XXXX .

@entity19 @entity134 @entity172 @entity53
These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to @entity53 . Serum LH levels were compared in juvenile, peripubertal, and adult female @entity19 after ovariectomy and challenge with a variety of 4-day @entity134 treatments. Since male stimuli accelerate the attainment of puberty in this species, comparisons also were made between age- and weight-matched groups of pre- vs. postpubertal females, obtained by housing them in either the presence or absence of males. The following conclusions were derived from eight experiments. 1) Progressively more @entity53 is required to suppress the postovariectomy rise in serum LH as the female @entity19 develops the juvenile stage to full adulthood. 2) This slow, progressive change is due in part to a steadily increasing capacity to secrete LH when unhindered by any negative feedback regulation by the ovary; it is not due to developmental changes in @entity53 metabolism. 3) The LH surging mechanism is functional and already coupled to its circadian oscillator in the juvenile @entity19 , but surges of adult magnitude could not be induced with exogenous @entity134 until the peripubertal period. 4) The @entity53 requirements for preovulatory LH surging change markedly after the peripubertal stage of development; a wide range of temporal changes in blood @entity53 levels will elicit LH surging in the adult @entity19 , but the immature female requires a rigid pattern of change involving only a narrow range of blood levels of this @entity134 . 5) Exposure of peripubertal females to male stimuli alters neither their negative feedback sensitivity to @entity53 nor their @entity172 requirements for LH surging. These conclusions are integrated into two working models that focus first on the @entity172 requirements for LH surging in the adult @entity19 , and second on the maturation of this process and the attainment of pubertal ovulation. (Endocrinology 108: 506, 1981)
