Young age as favorable prognostic factor for XXXX -specific survival in @entity1358 .

@entity1 @entity1358 @entity5 @entity19409
OBJECTIVES: To evaluate the prognostic effect of age in @entity1 with @entity1358 ( @entity1358 ) and investigate the incidence of Xp11 translocation @entity1358 in young @entity1 who developed recurrence. METHODS: From 1990 to 2007, 2403 Japanese @entity1 underwent nephrectomy for presumed @entity1358 at 9 institutions. Of those, 1143 @entity1 had localized @entity1358 (Stage pT1-2N0M0). Their clinical data were retrospectively reviewed. In the present study, 131 @entity1 (11%) were considered young ( <=45 years at diagnosis). In the young @entity1 with recurrence, the nephrectomy specimens were immunostained with @entity19409 to determine the incidence of Xp11 translocation @entity1358 . RESULTS: During the median follow-up of 47 months, 3 @entity5 deaths (2.2%) occurred among young @entity1 and 51 (5.0%) among older @entity1 . The 5-year @entity5 -specific survival (CSS) rate was significantly better for the younger @entity1 than for the older @entity1 (P = .049). Multivariate analysis showed that age was significantly associated with CSS, as were the pathologic T stage, @entity5 grade, and symptoms at diagnosis. The hazard ratio of young age was 0.31 (95% confidence interval 0.077-0.87). The recurrence-free survival curves revealed no difference between these 2 groups. Of the 74 @entity1 with recurrence, the CSS after recurrence was significantly better in the younger @entity1 than in the older @entity1 (P = .0010). Of the 8 young @entity1 with recurrence, 4 had Xp11 translocation @entity1358 , and 3 survived for >5 years after recurrence. CONCLUSIONS: Compared with the older @entity1 , the young @entity1 with @entity1358 had similar recurrence-free survival rates but better CSS rates. This might have been because significant numbers of the young @entity1 had Xp11 translocation @entity1358 .
