Relevance of host-derived and bacterial factors in @entity796 XXXX .

@entity796 @entity16 @entity95 @entity2348 @entity57144 @entity281 @entity3283
Two pathogenic mechanisms of @entity796 @entity281 are discussed, one involving bacterial exoenzymes, the other involving polymorphonuclear leukocyte (PMN)-derived lysosomal enzymes. The objective of the present study was (1) to show the relative importance of the two mechanisms and (2) to evaluate the effect of active immunization against @entity796 exoenzymes on @entity16 . @entity95 were immunized against @entity796 alkaline protease (AP) or elastase ( @entity57144 ) and challenged with the respective enzymes. @entity16 was studied by light photography (LP). In another group, @entity95 were immunized against AP, @entity57144 and exotoxin A (ExoA) and challenged with @entity796 strains PA01 or PA103. @entity16 was studied with LP, light microscopy, and electron microscopy. Immunized animals were totally protected against intracorneal inoculation of @entity796 proteases. Twelve hr and 24 hr after challenge with whole bacteria, immunized @entity95 revealed less @entity16 than non-immunized animals. However, after 48 hr @entity16 (ie severe @entity3283 ) was comparable in both groups. The study suggests that @entity16 involving lysosomal enzymes from stimulated PMN is more important after @entity2348 than direct damage by @entity796 exoenzymes.
