Prognostic importance of Mandard tumour regression grade following pre-operative chemo/radiotherapy for locally advanced XXXX .

@entity1 @entity22576 @entity416 @entity5 @entity49626 @entity17198 @entity17199 @entity55053
PURPOSE: To assess the prognostic value of the Mandard tumour regression score (TRG) following pre-operative chemo/radiotherapy in @entity1 with locally advanced @entity5 . METHODS AND MATERIALS: The study involved 158 @entity1 with locally advanced @entity5 treated with pre-operative long course chemo/radiotherapy at Nottingham University Hospital between April 2001 and December 2008. @entity1 were treated with radiotherapy to a dose of 50 Gy in 25 fractions over 5 weeks with or without concurrent @entity416 chemotherapy at a dose of 1650 mg/m(2)/day. Surgery was normally performed after an interval of 6-10 weeks. The response to pre-operative treatment was carefully graded by a single pathologist using the five point Mandard score. The median follow-up was 40 months (range 3-90 months). RESULTS: Of the 158 @entity1 14% were @entity17198 , 41% were @entity17199 , 31% were @entity22576 , 13% were @entity55053 and 1% were @entity49626 . The groups were combined into @entity17198 , @entity17199 and @entity22576 -5 to simplify further analysis. The Mandard score was clearly related to both disease-free (p < 0.001) and overall survival (p = 0.012). On multivariate analysis perineural invasion, nodal status, TRG and circumferential resection margin status were the most powerful predictors of disease-free survival. CONCLUSIONS: The Mandard tumour regression score is an independent prognostic factor and predicts for long-term outcome following pre-operative chemo/radiotherapy in @entity5 .
