HLA- DR Alleles in Pakistani @entity1 of XXXX .

@entity1 @entity7271 @entity1098 @entity1533 @entity1345
OBJECTIVE: To determine frequency of HLA-DR alleles in Pakistani @entity1 of @entity7271 in comparison with local healthy controls. STUDY DESIGN: Cross-sectional, comparative study. PLACE AND DURATION OF STUDY: Department of Immunology, @entity1345 ( @entity1345 ), Rawalpindi, from January 2011 to January 2014. METHODOLOGY: Twenty eight @entity1 with biopsy proven diagnosis of @entity7271 referred from Department of Dermatology, Military Hospital, Rawalpindi were included. @entity1 were compared with a group of 150 unrelated local healthy subjects. DNA was extracted from peripheral blood collected in Tri- @entity1098 . @entity1533 typing was carried out on allele level ( @entity1533 *01 - @entity1533 *16) using SSP (sequence specific primers). HLA type was determined by agarose gel electrophoresis and results recorded. Phenotype frequency of various alleles among @entity1 group and control group was calculated by direct counting and significance of their association was determined by Fisher's exact test/ Chi square test. RESULTS: A total of 12 male and 16 female @entity1 , with age ranging from 21 to 34 (mean 23.4 years) were genotyped for @entity1533 loci. A statistically significant association of the disease with @entity1533 *04 was observed (50% versus 20.7% in controls, p < 0.05). CONCLUSION: There is a strong association of @entity1533 *04 with @entity7271 in Pakistani population.
