Study of the XXXX content of mucus glycoproteins from normal and diseased colons.

@entity1 @entity9928 @entity31 @entity1735 @entity1960 @entity3913 @entity30
1. Mucus samples obtained from colectomy colons from 10 @entity1 with @entity31 and four @entity1 with @entity30 of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated from mucosal scrapings by gel-permeation chromatography. The high-molecular-weight fraction consisted largely of mucus glycoproteins and was further purified to the glycopolypeptides. The low-molecular-weight fraction contained a glycoprotein with a high @entity3913 content. The @entity1735 content of both the mucus glycoprotein and glycopolypeptide fractions were significantly reduced in active @entity1960 . 3. Oligosaccharides were prepared from the mucus glycoprotein material. In the normal material more than half the units contained eight or more @entity9928 residues, whereas in the disease material the bulk of the units were smaller than this.
