MicroRNA-338 inhibits migration and proliferation by targeting XXXX -induced factor 1a in nasopharyngeal carcinoma.

@entity135 @entity7738 @entity5 @entity900 @entity519 @entity3
UNASSIGNED: @entity5 ( @entity5 ) is an endemic type of @entity135 with a high rate of cervical lymph node @entity3 . An increasing number of studies have shown that microRNAs (miRNAs) play a key role in the development and progression of @entity5 . miR-338-3p has been demonstrated as an anti-oncogene in different @entity5 . The aim of the present study was to investigate the potential role of miR  -338-3p in the development and progression of @entity5 . Compared with normal samples, our data showed that miR-338-3p were downregulated in @entity5 tissues and cells. The luciferase assay demonstrated that @entity7738 was a direct target of miR-338-3p. We also found that miR-338-3p regulated the expression levels of @entity7738 , respectively. Overexpression of miR-338-3p in @entity5 cells significantly inhibited cell proliferation, and migration. Conversely, miR-338-3p knockdown in cells with lower endogenous expression levels significantly reduced antitumor behavior. Furthermore, enforced expression of miR-338-3p led to a decline in ERK phosphorylation as well as inhibited the @entity519 induced epithelial to mesenchymal transition. Cells pre-transfected with miR-338-3p can overcome @entity519 -mediated @entity900 resistance. Taken together, we found that miR-338-3p directly targeted @entity7738 , and we provide insight into @entity5 initiation and progression, possibly representing a novel therapeutic target.
