Development of mammalian endocochlear potential: normal ontogeny and effects of XXXX .

@entity18129 @entity519 @entity413 @entity600
The development of the positive endocochlear potential (EP), the negative anoxic EP, and the organ of Corti potential were measured at various postnatal ages in the Mongolian gerbil, beginning at 8 @entity600 ( @entity600 ). The organ of Corti potential (OCP) was present at 8 @entity600 but averaged 21% less than the adult value. OCP increased regularly with age, reaching adult values of -90 mV by 14 @entity600 . The positive EP was first observed at 10 @entity600 , at which age it averaged only 2-3 mV. This potential increased monotonically between 10 and 20 @entity600 , by which time it had reached the adult value of 75 mV. @entity519 did not result in a negative EP until 12 @entity600 , at which age this potential averaged -7 mV. The negative anoxic EP matured more rapidly than the positive EP, achieving the adult value of 40 mV by 18 @entity600 . During development the positive EP appeared to closely parallel the maturation of @entity413 metabolism in the stria vascularis. The negative anoxic EP was more closely related temporally to the development of @entity18129 ( @entity18129 ) thresholds. It is hypothesized that changes which occur between 10 and 16 @entity600 in the apical membranes of the cochlear hair cells contribute to the maturation of both @entity18129 and the negative anoxic EP.
