Blunted XXXX Activity in Suicide Attempters Compared to those at High Risk for Suicidal Behavior.

@entity308 @entity146 @entity1316 @entity2339 @entity701 @entity734
UNASSIGNED: Studies looking at the relationship of the @entity2339 to suicidal behavior and its risk factors, such as @entity308 , @entity734 , and @entity146 , report inconsistent results. These studies also do not always differentiate between subjects who go on to attempt suicide, suicidal subjects who never attempted suicide, and non-suicidal subjects with @entity146 . In this study, we examined @entity701 responses to an experimental stressor, the Trier Social Stress Test (TSST), in 208 offspring of parents with @entity1316 . Offspring suicide attempters showed lower total @entity701 output (b=-0.47, 95% CI (-0.83, -0.11), p=0.01) compared with offspring with suicide-related behavior (SRB) but never attempted, non-suicidal offspring, and a healthy control group. The result remained significant even after controlling for sex, age, race, ethnicity, site, socio-economic status, and hour of the day when the TSST was conducted. Suicide attempters also showed lower baseline @entity701 before the TSST (b=-0.45, 95% CI (-0.74, -0.17), p=0.002). However, there were no significant differences between the groups on @entity701 reactivity to stress (b=4.5, 95% CI (-12.9, 22), p=0.61). Although subjects with suicide attempt and SRB have similar clinical and psychosocial characteristics, this is the first study to differentiate them biologically on @entity2339 indices. Blunted @entity2339 activity may increase risk for suicide attempt among individuals with psychopathology by reducing their ability to respond adaptively to ongoing stressors. These results may help better identify subjects at high risk for suicidal behavior for targeted prevention and intervention efforts.Neuropsychopharmacology advance online publication, 4 November 2015; doi:10.1038/npp.2015.309.
