The superparamagnetic XXXX is equivalent to the Tc99 radiotracer method for identifying the sentinel lymph node in @entity0 .

@entity1 @entity1933 @entity0
BACKGROUND: Preoperative injection of Tc99 is standardly performed before sentinel lymph node biopsy (SLN) for @entity0 . Multiple questions have arisen concerning appropriate technique for SLNBs including site of injection, timing and injection material. The aim of this study was to assess the concordance between a new method, superparamagnetic @entity1933 (SPIO) and the Tc99 radiotracer to identify the SLN in early @entity0 . MATERIAL AND METHODS: Between July 2013 and March 2014, 120 @entity1 with clinically node negative early @entity0 were included in the study. @entity1 were injected the day before the radiotracer for lymphoscintigraphy and injected the SPIO subareolar intraoperatively. SLN was excised if it was radioactive, magnetic or palpable. @entity1 signed an inform consent. RESULTS: There was no drainage by either technique in 2 @entity1 , so this leaves 118 @entity1 for further analysis. Detection rate by Tc 99 was successful in 113 (95.7%%) @entity1 and by SPIO in 116 (98.3%). Concordance rates per @entity1 between techniques was 98.2%. The SLN was positive in 36 (30%) @entity1 . Of this, SLN positivity was detected by both techniques in 32 @entity1 . Mean number of SLNs by 99Tc and SPIO were 1.9 and 2.21 respectively (p  =  0.001). DISCUSSION: Detection of SLNs with SPIO allows for easy identification of axillary nodes, at a frequency not inferior to the radiotracer. It is an oncologically safe procedure, facilitates @entity1 and operative room management and can be used to reliably identify SLNs in @entity0 .
