The @entity71676 inflammasome attenuates @entity1960 and @entity1960 -associated XXXX .

@entity1 @entity32 @entity6026 @entity368 @entity5 @entity19 @entity635 @entity71676 @entity694 @entity71677 @entity29 @entity344 @entity1960 @entity105
Nucleotide-binding domain and @entity368 -rich repeat (NLR) proteins are a diverse family of pattern recognition receptors that are essential mediators of @entity32 and host defense in the gastrointestinal system. Recent studies have identified a subgroup of inflammasome forming NLRs that modulate the mucosal immune response during @entity29 ( @entity29 ) and @entity1960 associated @entity105 . To better elucidate the contribution of NLR family members in @entity29 and @entity5 , we conducted a retrospective analysis of gene expression metadata from @entity1 @entity1 . These data revealed that @entity71676 , an inflammasome forming NLR, was significantly dysregulated in @entity29 and @entity694 . To better characterize the function of @entity71676 in disease pathogenesis, we used @entity71677 (-/-) @entity19 in @entity1960 and @entity1960 -associated @entity5 models. In this paper, we report that @entity71676 attenuates @entity344 and @entity105 . @entity71677 (-/-) @entity19 demonstrated significant increases in morbidity, @entity32 , and @entity105 compared with wild-type animals. Similar to data previously reported for related inflammasome forming NLRs, the increased @entity32 and @entity5 burden was correlated with attenuated levels of @entity635 and @entity6026 . Further mechanistic studies using bone marrow reconstitution experiments revealed that the increased disease pathogenesis in the @entity71677 (-/-) @entity19 was associated with nonhematopoietic-derived cells and suggests that @entity71676 functions in the colon epithelial cell compartment to attenuate @entity105 . Taken together, these data identify @entity71676 as an essential mediator of the host immune response during @entity29 and @entity5 . These findings are consistent with a model whereby multiple NLR inflammasomes attenuate disease pathobiology through modulating @entity635 and @entity6026 levels in the colon.
