Health risks from increases in XXXX exposure.

@entity1 @entity1032 @entity137 @entity39 @entity349 @entity5219 @entity5434 @entity4968 @entity5165 @entity194 @entity2359 @entity306
Our present knowledge of the @entity1 health effects of @entity5165 exposure is derived from study of major outbreaks of @entity1 @entity4968 in Japan and Iraq and experimental studies on primates. @entity5165 readily passes through such physiological barriers as the blood-brain barrier, blood-testes barrier, and the placenta. Its major pathological effects are on the nervous and reproductive systems and the developing embryo/fetus. The @entity2359 of @entity5165 is well established in both @entity1 and non- @entity1 primates. Lesions in the cerebral and cerebellar gray matter consist of @entity39 and lysis of neurons, phagocytosis and @entity5219 . The changes are most prominent in the deep sulci and may have a vascular component. A late effect is @entity194 . At high dose levels the liver, kidneys, and other organs may also have degenerative changes. Although not yet described in @entity1 , a major effect of exposure of female primates is an adverse effect on pregnancy. Maternal female @entity5434 blood @entity349 levels above 1 ppm are associated with a decreased pregnancy rate and increased abortion rate. To date our experimental data lack sufficient numbers to detect infrequent pregnancy effects below 1 ppm. Preliminary studies also reveal that @entity5165 may also decrease the number and function (swim speed) of sperm. Both @entity1 and primate studies demonstrate deleterious effects of @entity5165 on the developing embryo/fetus. Autopsies on @entity1 and primate @entity1 @entity1032 brain development and the occurrence of a @entity306 -like behavior in the newborns, whereas the mother may be free of signs and symptoms of @entity5165 @entity137 . The fetal blood level of @entity349 is higher than the maternal level.(ABSTRACT TRUNCATED AT 250 WORDS)
