Allergic sensitization, XXXX , and @entity286 smoke exposure in U.S. @entity1 and adolescents.

@entity1 @entity286 @entity6766 @entity4874 @entity2490 @entity56 @entity6765
BACKGROUND: Childhood @entity286 exposure has been linked with sinonasal pathology, and may be associated with @entity56 sensitization. This study evaluates the association between exposure to active smoking or secondhand smoke (SHS) and the prevalence of @entity2490 and @entity56 sensitization in the U.S. pediatric population. METHODS: Cross-sectional study in 2714 @entity1 and adolescents aged 6 to 19 in the National Health and Nutrition Examination Survey (NHANES), 2005-2006. Active smoking was defined as self-reported smoking or serum @entity4874 concentrations >10 ng/mL. SHS was defined as nonactive smokers who reported living with >= 1 smokers or had serum @entity4874 >= 0.011 ng/mL. Self-reported @entity2490 was based on symptoms during the past 12 months, and allergen sensitization was defined as a positive response to any of the 19 specific immunoglobulin E (IgE) antigens tested. RESULTS: About half of the population (54%) had detectable levels of IgE specific to at least 1 of the tested allergens, and 25% reported a history of @entity2490 . After multivariate adjustment, an increased prevalence rate ratio (PRR) of self-reported @entity2490 was seen in individuals in the highest @entity4874 tertile among active smokers ( @entity6765 .73; 95% confidence interval [CI], 1.23 to 2.43), with a significant trend between increasing @entity4874 levels in individuals exposed to either secondhand smoke or active smoking (p = 0.05 for both analyses). Significantly less @entity6766 was observed in @entity1 in the highest @entity4874 tertile of secondhand smoke (PRR, 0.61; 95% CI, 0.43 to 0.85). CONCLUSION: @entity286 smoke exposure was associated with increased prevalence of @entity2490 symptoms, but decreased prevalence of @entity56 sensitization. The results highlight the complex relationship between @entity286 exposure and sinonasal pathology.
