Treating chronic @entity2701 not responding to XXXX with @entity903 : a pilot evaluation.

@entity1 @entity3659 @entity903 @entity158 @entity2701 @entity10
CONTEXT: In some individuals, chronic @entity2701 fails to respond to tricyclic antidepressant medications that often serve as first-line therapy. OBJECTIVE: To evaluate the clinical efficacy of @entity903 for chronic @entity2701 not responding to @entity3659 . DESIGN AND SETTING: Open-label trial of @entity903 conducted at 2 outpatient sites in Ohio. @entity1 AND INTERVENTION: Thirty-one adults (mean age, 37 years; 20 @entity1 ) with chronic @entity2701 (mean, 25 @entity10 days per month) who had failed to respond (less than 30% improvement) to treatment with either @entity3659 (n = 13) or matched placebo (n = 18). All @entity1 were treated with @entity903 (up to 40 mg per day) in a 9-month protocol. OUTCOME MEASURES: Monthly @entity10 index calculated as the mean of @entity158 ratings (0 to 10 scale) recorded by @entity1 in a diary 4 times per day, number of days per month with at least moderate @entity158 ( @entity158 rating of 5 or greater), and analgesic medication use. RESULTS: In @entity1 who had not responded to @entity3659 , @entity903 failed to reduce chronic @entity2701 or analgesic medication use. In @entity1 who had not responded to placebo, @entity903 produced modest reductions in chronic @entity2701 and analgesic use. CONCLUSIONS: We found no evidence that chronic @entity2701 that failed to respond to tricyclic antidepressant therapy with @entity3659 improved when subsequently treated with @entity903 . More support was found for the efficacy of @entity903 in @entity1 with chronic @entity2701 who had failed to respond to placebo.
