XXXX : a clinicopathologic review of 60 cases.

@entity1 @entity39 @entity5 @entity1911 @entity1425 @entity3 @entity1063
The clinical and pathologic features of 60 @entity1911 were reviewed in an attempt to evaluate the utility of histopathologic evaluation in predicting the prognosis for these @entity5 . Fifty-five @entity5 were benign, and five were malignant, characterized either by histologically proved @entity3 or by extensive local invasion. The prevalence of all parameters studied was compared between the benign and malignant groups. Three differences were observed between the benign and @entity5 . The @entity5 were usually larger, had extensive areas of @entity39 , and were composed of small cells. In agreement with the results of previous investigations, the morphologic criteria generally used to predict the behavior of @entity5 , i.e., nuclear atypia, capsular and vascular invasion, and mitotic activity, were of little value in predicting the behavior of @entity1911 . @entity5 , all of which had membrane-bound, cytoplasmic granules, were examined electron microscopically. A minority of these @entity5 fit the classic descriptions of " @entity1063 " and "epinephrine" granules reported in the literature, while the majority of the granules had features of both types, precluding definitive classification. As a result of these observations, the currently accepted criteria of @entity1063 and @entity1425 granules were questioned. A review of the literature cast further doubt on the existence of a correlation between granule content and morphology. Both of the @entity1 with locally invasive @entity5 were alive and well eight and 28 years following diagnosis and radical surgery. In contrast, the @entity1 with histologically proved distant @entity3 died within one year of diagnosis. These observations suggest that locally invasive @entity5 may not have the same dismal prognosis as @entity1911 that have metastasized.
