Comparison of relative cerebral blood volume and proton spectroscopy in @entity1 with treated XXXX .

@entity1 @entity1313 @entity5 @entity11 @entity1877
BACKGROUND AND PURPOSE: Elevated relative regional cerebral blood volume (rCBV) reflects the increased microvascularity that is associated with @entity1313 . The purpose of this study was to investigate the potential role of rCBV in the determination of recurrent/residual disease in @entity1 with treated @entity11 . METHODS: Thirty-one rCBV studies were performed in 19 @entity1 with treated @entity11 . All @entity1 also had proton MR spectroscopy and conventional MR imaging. Regions of abnormality were identified on conventional MR images by two neuroradiologists and compared with rCBV and MR spectroscopic data. Metabolites and rCBV were quantified and compared in abnormal regions. RESULTS: In high-grade @entity5 , rCBV values were proportional to @entity1877 in regions of @entity5 and nonviable tissue. Although the presence of residual/recurrent disease was often ambiguous on conventional MR images, the rCBV maps indicated regions of elevated vascularity in all low-grade @entity5 and in 12 of 17 grade IV lesions. Regions of elevated and low rCBV corresponded well with spectra, indicating @entity5 and nonviable tissue, respectively. CONCLUSION: This study suggests that rCBV maps and MR spectroscopy are complementary techniques that may improve the detection of residual/recurrent @entity5 in @entity1 with treated @entity11 . Compared with the spectra, the rCBV maps may better reflect the heterogeneity of the @entity5 regions because of their higher resolution. The multiple markers of MR spectroscopy enable better discrimination between normal and abnormal tissue than do the rCBV maps.
