Maternal @entity844 status in pregnancy and childhood @entity1097 : XXXX Birth Cohort Study.

@entity1 @entity483 @entity844 @entity565 @entity1097 @entity1426 @entity1474 @entity34075 @entity56 @entity74 @entity1718 @entity484
BACKGROUND: Prevalence of @entity74 has increased rapidly, but aetiological factors responsible for this increase are still largely unknown. Prenatal exposure to a pro-inflammatory @entity844 status is hypothesized although little research has been carried out. OBJECTIVE: To investigate whether prenatal @entity844 exposures are associated with atopy in childhood. METHODS: In the @entity34075 Birth Cohort Study, maternal blood samples (n=1275) at 34-36 weeks of pregnancy were assayed for n-6 and n-3 long-chain @entity1474 (LCPs). The full spectrum of offspring @entity1097 (wheeze, @entity565 , @entity56 , @entity484 , @entity483 , @entity56 sensitization, and high total IgE) until the age of 6-7 years was assessed by repeated parental questionnaires and measurements of total and specific IgE. Associations of maternal @entity844 status with @entity1 atopic outcomes were analysed using multivariable logistic regression and generalized estimating equations for repeated measurements. RESULTS: High ratio of maternal n-6 vs. n-3 LCPs was associated with a lower risk of @entity484 in the @entity1 (P for trend 0.012). More specifically, we found a decreased risk of @entity484 in the first 7 months of life with increasing @entity1426 levels (P for trend 0.013). No associations were found between maternal @entity1718 and offspring airway-related @entity1097 , sensitization, or high total IgE. CONCLUSION AND CLINICAL RELEVANCE: The development of @entity74 in early childhood is associated with prenatal exposure to n-6 vs. n-3 @entity1718 , but with inconsistencies between different manifestations. Further exploration of associations with maternal diet and genetic variants in genes regulating @entity844 metabolism are required. This study shows that the influence of prenatal exposure to @entity1718 on the risk of @entity484 in the @entity1 is limited to the first year of life.
