Altered @entity2671 and @entity1815 dynamics associated with abnormal hormonal profiles in amenorrheic subjects with XXXX or @entity28 .

@entity1 @entity4089 @entity3610 @entity43 @entity353 @entity28 @entity2671 @entity53 @entity3800 @entity1815 @entity2588 @entity1386
The present study was designed for exploration of hormonal disturbances underlying common forms of @entity2588 . @entity3610 ( @entity3610 ) @entity1 and @entity28 amenorrheic subjects had significantly elevated @entity1815 (E1) levels, elevated luteinizing hormone/follicle-stimulating hormone ratios, and an exaggerated luteinizing hormone response to luteinizing hormone-releasing hormone. However, @entity2671 (delta 4A), the precursor of E1, was elevated only in @entity3610 . Thus, the E1/delta 4A ratio, which provides an indirect index of aromatase activity in extraglandular sites, was raised in @entity28 subjects as a group but not in @entity3610 subjects. These findings suggest that elevated E1 levels, which give rise to abnormal gonadotropin secretion, arise from increased available @entity3800 in @entity3610 but from an increased effect of aromatase (present in adipose tissue) in @entity28 subjects. Measurement of @entity3800 and the E1/delta 4A ratio provides insights into the relative contributions of @entity3610 and enhanced aromatase activity to the genesis of @entity2588 in these groups. In @entity1 with suppressed @entity53 levels associated with @entity4089 or @entity353 , follicle-stimulating hormone levels were suppressed, while luteinizing hormone was not elevated. Prolactin excess explains these findings in @entity4089 . Plasma E1 levels and the E1/delta 4A ratio were suppressed in @entity1 with @entity353 , possibly as a consequence of reduced @entity1386 . This finding suggests that hypothesis that a minimum level of E1, dependent upon adequate @entity1386 , is critical for the normal mature function of the @entity43 . Abnormal E1/delta 4A ratios, high in @entity28 -associated @entity2588 and suppressed in @entity353 -associated @entity2588 , may provide specific markers for these groups of @entity1 .
