[Tumor profiling of XXXX : relevance for diagnostics and therapy].

@entity1 @entity5 @entity12728 @entity1358 @entity3
Molecular biological @entity5 markers and prognostic parameters are necessary for differential diagnosis, individual prognosis, and therapy in @entity1 with @entity1358 . By using high throughput technologies, it is possible to characterize @entity5 samples comprehensively. Based on specific genetic alterations, histopathological subtypes were defined as independent @entity5 entities. Genetic characteristics can be used for diagnosis of @entity5 samples and also of biopsies. Furthermore, specific molecular patterns of @entity3 are known, allowing the determination of the @entity5 's metastatic potential. The specific protein patterns of serum samples of @entity5 @entity1 were analyzed, and several candidate proteins have been identified. One of these is @entity12728 , which is elevated in @entity1 with @entity1358 ( @entity1358 ). New therapeutic options are now available for @entity1 with metastatic @entity1358 . Therefore, it is necessary to select the best therapy for each @entity1 and to detect therapy resistance very early. Biomarkers in @entity5 tissue and serum were found to correlate with therapy response.
