Echocardiographic and Hemodynamic Predictors of Survival in XXXX : Seven-Year Follow-Up.

@entity1 @entity101 @entity2294 @entity120 @entity997 @entity1031 @entity67 @entity204 @entity65
BACKGROUND: In this study, we looked at the prognostic value of echocardiographic and hemodynamic measures in a large cohort of @entity1 with @entity120 before and after initiation of treatment. METHODS AND RESULTS: Data were collected prospectively in a cohort of consecutive @entity1 with @entity120 referred between 2002 and 2011. A range of clinical and echocardiographic variables were collected and stored on a database to assess predictors of survival. Invasive hemodynamic data including pulmonary artery pressure, pulmonary vascular resistance, capillary wedge pressure, and cardiac index were also obtained at baseline in all @entity1 . Outcome was defined as mortality because of @entity65 . The study cohort comprised 777 @entity1 (514 @entity1 ) with @entity120 . A total of 195 (25%) died. In multivariable analysis, moderate or severe @entity997 (hazard ratio [HR], 26.537; 95% confidence interval, 11.536-61.044; P<0.001), right ventricular myocardial performance index (HR, 3.421; 95% confidence interval, 1.777-6.584; P<0.001), and the presence of @entity2294 (HR, 1.38; 95% confidence interval, 1.023-1.862; P=0.035) were independent predictors of mortality. High pulmonary vascular resistance and right atrial pressure by invasive hemodynamic measurements were independent predictors of mortality (HR, 1.084; 95% confidence interval, 1.041-1.130, and 1.079, respectively; 95% confidence interval, 1.049-1.111; P<0.001 for both), whereas @entity1 with a higher cardiac index had better survival overall (HR, 0.384; 95% confidence interval, 0.307-0.481; P<0.001). CONCLUSIONS: Right @entity67 , moderate-severe @entity997 , low cardiac index, and raised right atrial pressure were associated with poor survival for both @entity120 and chronic @entity1031 pulmonary @entity101 @entity1 . The severity of @entity997 , myocardial performance index, presence of @entity2294 , pulmonary vascular resistance, cardiac index, and right atrial pressure may be used to stratify risk of @entity204 .
