@entity1089 XXXX : a case series.

@entity1 @entity410 @entity149 @entity4968 @entity772 @entity204 @entity551 @entity1370 @entity591 @entity1576 @entity7129 @entity933 @entity943 @entity1445 @entity1089
STUDY OBJECTIVE: We describe the effects of @entity1089 in @entity1445 . METHODS: @entity1089 poisonings were identified from a prospective database of @entity4968 admissions to a regional toxicology service. Data extracted included details of ingestion, clinical features, investigations (including ECG), and other outcomes (length of stay and ICU admission rate). RESULTS: There were 45 cases of @entity1089 @entity1445 , of which 18 @entity1 with @entity1089 assay results were included. Median length of stay was 35 hours (interquartile range [IQR] 14 to 42 hours) for the 18 @entity1 , and 9 were admitted to the ICU. The median ingested dose was 3.5 g (IQR 1.7 to 6.2 g), and reported ingested dose was highly correlated with estimated peak drug concentration (r(2)=0.84; P<.0001), confirming @entity1 -provided history of ingestion. @entity410 occurred in 2 @entity1 , @entity933 occurred in 3 @entity1 , and mechanical ventilation was required in 4 @entity1 . No @entity943 or @entity204 occurred. Six of the 18 @entity1 ingested @entity1089 alone, with a median length of stay of 35 hours, and 3 were admitted to the ICU. In 1 @entity1 who ingested 24 g, @entity551 and @entity410 occurred. For 10 @entity1 for whom ECGs were available and who had ingested no @entity1370 drugs, @entity591 occurred in 8 @entity1 . For these 10 @entity1 , the mean corrected QT (QTc) interval was increased at 487 ms, but the mean uncorrected QT interval was 349 ms. Reported dose and peak @entity1089 concentrations were significantly associated with ICU admission and length of stay more than 24 hours. A reported dose less than 3 g and a Glasgow @entity772 Scale score not less than 15 predicted @entity1 not requiring ICU admission or length of stay more than 24 hours. CONCLUSION: @entity1089 @entity1445 causes @entity149 and @entity7129 . In large @entity1445 , @entity1 may require intubation and ventilation for associated @entity1576 . Although a prolonged QTc occurs, its clinical significance is unclear because it is most likely caused by an overcorrection caused by the @entity591 . In our experience, a reported dose of less than 3 g for @entity1 who are not drowsy (with a Glasgow @entity772 Scale score of 15) at least 4 hours after ingestion and who did not coingest another toxic agent defined a group not requiring ICU admission or inpatient admission greater than 24 hours.
