Cortical cholinergic function is more severely affected in @entity191 than in XXXX : an in vivo positron emission tomographic study.

@entity1 @entity303 @entity191 @entity51 @entity195 @entity10810 @entity528
BACKGROUND: Pathology reports have shown that @entity528 in @entity191 ( @entity191 ) are equal to or greater than those in @entity195 ( @entity195 ). We hypothesized that @entity1 with @entity191 would have @entity51 that were similar to or greater than those of @entity1 with @entity195 . OBJECTIVE: To determine in vivo cortical @entity10810 ( @entity10810 ) activity in healthy control subjects and in @entity1 with mild @entity195 , @entity191 , and @entity191 without @entity303 using @entity10810 positron emission tomography. SETTING: University and Veterans' Administration medical center. Design and @entity1 Group comparison design of @entity1 with @entity195 (n = 12), @entity191 (n = 14), and @entity191 without @entity303 (n = 11), and controls (n = 10) who underwent @entity10810 imaging between July 1, 2000, and January 31, 2003. @entity1 with @entity195 and @entity191 had approximately equal @entity303 severity. MAIN OUTCOME MEASURES: Cerebral @entity10810 activity. RESULTS: Compared with controls, mean cortical @entity10810 activity was lowest in @entity1 with @entity191 (-20.0%), followed by @entity1 with @entity191 without @entity303 (-12.9%; P<.001). Mean cortical @entity10810 activity was relatively preserved in @entity1 with @entity195 (-9.1%), except for regionally selective involvement of the lateral temporal cortex (-15%; P<.001). CONCLUSION: Reduced cortical @entity10810 activity is more characteristic of @entity1 with @entity191 than of @entity1 with mild @entity195 .
