@entity71594 alleviates @entity99 in a rodent model of XXXX -reperfusion.

@entity32 @entity63 @entity1421 @entity568 @entity5906 @entity71594 @entity2144 @entity1234 @entity3929 @entity842 @entity35 @entity99 @entity1865 @entity4645 @entity17104
OBJECTIVES: @entity63 -reperfusion (I/R) causes remote organ injury (e.g., @entity99 ). Oxidation and @entity32 are crucial mechanisms. We investigated the effects of @entity71594 , a potent antioxidative and anti-inflammatory drug, on alleviating @entity99 induced by limb I/R. METHODS: Twenty-four adult male @entity35 were randomized to receive sham operation (Sham), Sham plus @entity71594 , I/R, or I/R plus @entity71594 and designated as the Sham, Sham+Cep, I/R, or I/R+Cep group, respectively (n  =  6 in each group). I/R was induced by applying @entity2144 high around each hind limb for 3 hours followed by reperfusion for 24 hours. RESULTS: The plasma levels of @entity5906 aminotransferase (AST) and @entity3929 aminotransferase (ALT) of the Sham and Sham+Cep groups were low, and the levels of AST and ALT of the I/R group were significantly higher than those of the Sham group (both p<0.001). By contrast, the AST and ALT of the I/R+Cep group were significantly lower than those of the I/R group (both p<0.001). The hepatic levels of @entity842 (NO), @entity1234 ( @entity1865 ), @entity17104 ( @entity17104 ), @entity568 ( @entity568 ), and @entity4645 ( @entity4645 )/ @entity1421 (PGE2) of the Sham and Sham+Cep groups were also low. As expected, the NO, @entity1865 , @entity17104 , @entity568 , and @entity4645 /PGE2 of the I/R group were significantly higher than those of the Sham group (all p<0.001). By contrast, the NO, @entity1865 , @entity17104 , @entity568 , and @entity4645 /PGE2 of the I/R+Cep group were significantly lower than those of the I/R group (all p<0.05). CONCLUSION: @entity71594 alleviates @entity99 in a rodent model of limb I/R. The mechanisms may involve reducing oxidation and @entity32 .
