Supervised oral protein supplementation during dialysis in XXXX with elevated @entity1851 levels: a two phase, longitudinal, single center, open labeled study.

@entity1 @entity32 @entity29726 @entity1568 @entity22 @entity1851
BACKGROUND: @entity32 is considered one of the major causes of protein-energy wasting in @entity22 ( @entity22 ) @entity1 . It is unclear whether dietary interventions can impact nutritional status and quality of life in @entity22 @entity1 with elevated @entity1851 ( @entity1851 ) levels. Therefore, we examined the hypothesis that supervised intra-dialysis protein supplementation in @entity22 @entity1 with elevated plasma @entity1851 will improve protein stores and quality of life. METHODS: A 24  week, two phase, longitudinal, single center, open labeled study of 50 @entity22 @entity1 with plasma @entity29726  mg/L was conducted. During the 12-week observation phase dietary advice was provided to increase protein intake to 1.2  g/kg/day. In the 12-week treatment phase 45  g of liquid protein supplement was provided at each dialysis treatment. Protein @entity1568 appearance (PNA), mid-arm muscle circumference (MAMC), serum albumin, body mass index (BMI) and quality of life (assessed by Short Form-12 questionnaire) were measured at baseline, 12 and 24  weeks. RESULTS: Median plasma @entity1851 at baseline was 16.0 (IQR 7.7 to 25.1) mg/L. The mean MAMC was 26.5        3.9  cm, BMI 29.2        6.9  kg/m(2) and plasma albumin 3.8        0.3  g/dl. During the intervention period, mean PNA increased by 0.13  g/kg/d (p   =   0.01) under a mixed effects model. However, there were no clinically or statistically significant effects on MAMC (p   =   0.87), plasma albumin (p   =   0.70), BMI (p   =   0.09), physical (p   =   0.32) or mental (p   =   0.96) composite scores. CONCLUSIONS: In @entity22 @entity1 with elevated plasma @entity1851 but otherwise mostly normal nutritional parameters, intra-dialytic oral protein supplement was effective in increasing protein intake but did not provide a detectable impact on nutritional status or quality of life.
