Selective efferent chemical sympathectomy of XXXX kidneys.

@entity8 @entity2955 @entity1812 @entity35 @entity1063
Surgical denervation of kidneys results in interruption of both afferent and efferent @entity8 . We attempted selective efferent renal denervation in @entity35 by slow infusions of @entity2955 ( @entity2955 ) into the right renal artery. Integrity of efferent @entity8 was assessed by chemical and physiological methods and by measuring responses of mean arterial blood pressure (MAP) and heart rate (HR) to intrarenal (ir) infusion of @entity1812 in conscious @entity35 . Results were compared with those in surgically denervated and ir saline-infused @entity35 . Surgical denervation of left kidney reduced renal @entity1063 (NE) to 58 and 14% of control levels at 1 and 7 days, respectively, after surgery. Increase in left renal resistance during posterior hypothalamus (PH) stimulation was only 70 +/- 28% (n = 5) compared with 289 +/- 69% (n = 6) in control animals. Response in opposite kidney was unchanged. Although 0.1 mg @entity2955 ir caused considerable reduction of NE levels in both kidneys, responses to PH stimulation were unchanged. @entity2955 (1 mg) reduced NE levels in infused and control kidney and atria. Functional evidence for denervation was only obtained in the kidney infused with @entity2955 . Responses of MAP and HR to ir @entity1812 were unchanged 7 days after 1 mg @entity2955 . The data suggest that ir @entity2955 results in functional efferent sympathectomy without affecting afferent @entity8 .
