[Histological observation of the effects of tangential excision within twenty-four postburn hours on the progressive injury of the progression of deep partial XXXX burn wound].

@entity1 @entity227 @entity39 @entity3145 @entity2277 @entity121
OBJECTIVE: To evaluate the effects of early tangential excision on the prevention of the progression of deep partial @entity121 burn wound. METHODS: Twelve burn @entity1 with deep partial @entity121 burn wound were enrolled and received tangential excision of the burn wound within 24 postburn hours (PBHs). The histological samples were harvested from the wound before and 5 - 7 postoperative days (PODs) after the operation and the wound without operation 5 - 7 @entity227 ( @entity227 ). The samples were observed by means of HE staining, Masson's staining and the labelling of @entity2277 antigen positive cells by immunohistological skill. RESULTS: The inflammatory reaction of the burn wound without operation aggravated progressively along with that of disease and the tissue @entity39 area enlarged. And the residual skin appendages disappeared due to the enhanced inflammatory reaction. The brown area expanded and light green area shrinked by Masson's staining. The @entity2277 antigen positive cell count decreased significantly. But in the burn wound being performed tangential excision within 24 PBHs, focal inflammatory reaction exhibited evident ligher than that in burn wound without operation. Moreover, there appeared fresh granulation formation and partial epithelial coverage with no enlarged @entity39 tissue area in the operated wound when compared with that in non-operated wound (P < 0.05). Furthermore, the light green area exhibited no obvious shrinking by Masson's staining and the @entity2277 antigen positive cell count was much more in the operation area than that in non-operative area (P < 0.05). CONCLUSION: It might be beneficial to the host to perform tangential excision within 24 PBHs, which could remove burn wound @entity39 tissue in time and hamper the progression of @entity3145 . The healing process of deep partial @entity121 burn wound was therefore accelerated.
