Tissue factor-dependent pathway in severe XXXX revisited: a Brazilian cohort study.

@entity1 @entity11524 @entity1468
UNASSIGNED: Previously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white @entity1 with @entity1468 ( @entity1468 ) and suggested that plasma factor VII (FVII) levels can differentiate @entity1 with @entity1468 from healthy nonpregnant @entity1 or normal pregnant @entity1 , at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian @entity1 . A total of 240 @entity1 were studied. These included healthy nonpregnant @entity1 (n=79), normotensive pregnant @entity1 (n=80) and @entity1 with severe @entity1468 (n=81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and @entity11524 ( @entity11524 ). All study @entity1 were matched for age. Pregnant @entity1 (with/without @entity1468 ) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and @entity11524 were significantly increased in @entity1 with severe @entity1468 compared with healthy nonpregnant @entity1 (P<0.01) or normotensive pregnant @entity1 (P<0.01). FVIIa was also higher in normotensive pregnant @entity1 compared with nonpregnant @entity1 (P<0.01). However, no such significant trends were observed for plasma TF levels (P=0.074). In conclusion, circulating FVII, FVIIa and @entity11524 were significantly elevated in @entity1 with severe @entity1468 in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white @entity1 with @entity1468 . Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for @entity1468 , irrespective of ethnicity.
