Inflammatory markers and physical performance in middle-aged and older XXXX in Indonesia.

@entity1 @entity32 @entity308 @entity1851
BACKGROUND: although recent studies have suggested that @entity32 may play an important role in the process of ageing and in the development of disabilities, knowledge about the role of @entity32 in physical performance decline among middle-aged and older @entity1 in the context of developing countries is limited. OBJECTIVES: to examine the association between @entity1851 ( @entity1851 ) and the activities of daily living (ADL) among middle-aged (40-54 years old) and older (55-96 years old) @entity1 in Indonesia. DATA: data from a population-based sample, the Indonesia Family Life Survey (IFLS) 2007, were analysed. The data consist of 1,702 respondents of middle age (40-54 years old) and 2,017 older respondents who had completed information on ADL and @entity1851 . METHODS: @entity1851 concentrations in Dried Blood Spot (DBS) specimens were measured, using the validated enzyme-linked immunosorbent assay (ELISA) method. Thirteen items of ADL were used to measure physical performance. A three-level linear model was applied to take advantage of the nested structure of data at the individual level within the household and community levels. RESULTS: high levels of @entity1851 were significantly associated with lower ADL for middle-aged and older @entity1 (P < 0.001). The model was adjusted for co-morbid conditions, health risk factors, medications, @entity308 and sociodemographic characteristics. CONCLUSION: the significant association between the high level of @entity1851 and lower ADL among older @entity1 in Indonesia is in line with earlier studies in the context of developed countries. This study provides an extension in which the significant association was also found in middle-aged @entity1 (40-54 years old).
