Hearing impairment after XXXX -based chemotherapy in childhood.

@entity1 @entity5 @entity392 @entity393 @entity902
BACKGROUND: Chemotherapy is used in the treatment of @entity1 and adolescents with @entity5 . Some of the chemotherapeutic agents are highly toxic and may cause a number of side effects. The primary objective of this study was to evaluate the long-term effects on hearing in @entity5 survivors who had received @entity902 -based chemotherapy in childhood or adolescence. PROCEDURE: Medical records of 297 @entity1 , who had received treatment for @entity5 at the @entity1 's Hospital, Landspitali University Hospital in Iceland between 1981 and 2006, were retrospectively reviewed. Fifteen subjects fulfilled the eligibility criteria for the study and underwent an extended audiometric evaluation. RESULTS: The results showed that three of the subjects had a high frequency @entity393 . In one subject, we observed a hearing recovery just after the completion of chemotherapy, but the hearing deteriorated again some years later. Nine of the 15 subjects (60%) had @entity392 after the @entity5 treatment. An evaluation of subjective @entity393 and handicap (The Hearing Measurements Scale) revealed that some subjects had great difficulties with hearing in certain situations. The Hearing Measurement Scale showed that the pure-tone audiogram findings were only partly associated with the apparent hearing difficulties. CONCLUSION: Regular follow-up hearing examinations, which include both pure-tone audiogram investigations and subjective @entity393 assessments, should be performed during and after chemotherapy to identify subjects who require particular attention. This will ensure that @entity393 individuals are provided with the most suitable listening devices, to promote good speech and social development.
