Reductions in 28-day mortality following hospital admission for XXXX .

@entity1 @entity204 @entity360 @entity548
BACKGROUND _ AIMS: It is unclear whether mortality from @entity360 is changing: any differences observed might result from changes in age or comorbidity of @entity1 populations. We estimated trends in 28-day mortality in England following hospital admission for @entity360 . METHODS: We used a case-control study design to analyze data from all adults administered to a National Health Service hospital, for @entity360 , from 1999 to 2007 (n=516,153). Cases were @entity204 within 28 days of admission (n=74,992), and controls were survivors to 28 days. The 28-day mortality was derived from the linked national @entity204 register. A logistic regression model was used to adjust trends in nonvariceal and @entity548 mortality for age, sex, and comorbidities and to investigate potential interactions. RESULTS: During the study period, the unadjusted, overall, 28-day mortality following nonvariceal @entity548 was reduced from 14.7% to 13.1% (unadjusted odds ratio, 0.87; 95% confidence interval: 0.84-0.90). The mortality following @entity548 was reduced from 24.6% to 20.9% (unadjusted odds ratio, 0.8; 95% confidence interval: 0.69-0.95). Adjustments for age and comorbidity partly accounted for the observed trends in mortality. Different mortality trends were identified for different age groups following nonvariceal @entity548 . CONCLUSIONS: The 28-day mortality in England following both nonvariceal and variceal @entity360 decreased from 1999 to 2007, and the reduction had been partly obscured by changes in @entity1 age and comorbidities. Our findings indicate that the overall management of @entity548 has improved within the first 4 weeks of admission.
