Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced XXXX : a randomized preliminary study.

@entity1 @entity650 @entity137 @entity3136 @entity1356 @entity310 @entity1476 @entity2533 @entity236 @entity688 @entity20294
@entity1 undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. @entity3136 ( @entity3136 ) is a common and debilitating @entity137 side effect of autologous and allogeneic HSCT. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the severity of @entity3136 and inflammatory mediator ( @entity310 , @entity650 , @entity1356 , @entity688 , @entity2533 , metalloproteinases, and growth factors) levels in saliva and blood of HSCT @entity1 . Thirty @entity1 were randomly assigned to two groups: control (n   =   15) and laser (n   =   15). LLLT was applied from the first day of the conditioning regimen until day 7 post-HSCT (D   +   7). Saliva and blood were collected from @entity1 on admission (AD), @entity20294 , D   +   7, and on @entity236 ( @entity236 ). Clinical results showed less severe @entity3136 in the laser group (p   <   0.05). The LLLT group showed increased @entity1476 ( @entity1476 ) levels in saliva on D   +   7 (p   =   0.04). Significant differences were also observed for @entity688 on D   +   7 and on @entity236 in blood plasma, when compared to the control group (p   <   0.05). No significant differences were seen in saliva or blood for the other inflammatory mediators investigated. LLLT was clinically effective in reducing the severity of chemotherapy-induced @entity3136 in HSCT @entity1 , and its mechanism of action does not seem to be completely linked to the modulation of pro- or anti-inflammatory cytokines, growth factors or matrix metalloproteinases.
