Surgical resection of multifocal XXXX is associated with prolonged survival.

@entity5 @entity1 @entity2 @entity1149
BACKGROUND: Revisions in the international system for the staging of @entity2 , adopted in 1997, assigned the T4 descriptor to separate @entity5 nodules in the same lobe and the M1 descriptor to @entity5 nodules in a different lobe. Consequently, these changes shifted the stage of @entity1 with these lesions to stage IIIB or stage IV. The goal of this review was to determine the impact of multifocal @entity1149 on survival. METHODS: A database analysis of our cardiothoracic surgery @entity5 registry was performed to identify all @entity1 who underwent surgical resection of @entity1149 ( @entity1149 ), who were ultimately determined to have pathologically node-negative disease from 1994 to 1999. All pathology reports were individually reviewed. Survival data were collected on each @entity1 from the date of surgery with a mean duration of follow-up of 46.3 months. Kaplan Meier actuarial survival was determined for all @entity1 . RESULTS: Forty-four @entity1 were identified who underwent complete resection of multiple @entity1149 . During this same period, 504 @entity1 underwent complete resection of stage I @entity1149 . The 3-year actuarial survival for @entity1 with T1/N0/M0 @entity5 was 79.6%. In comparison with @entity1 with T1/N0/M0 @entity5 , the 3-year actuarial survival rates of @entity1 with T2/N0/M0 @entity5 (72.3%, p = 0.056), T4/N0/M0 @entity5 (66.5%, p = 0.058), and T1 to T2/N0/M1 @entity5 (63.6%, p = 0.201) were lower. However, these differences did not achieve statistical significance. CONCLUSIONS: Although there was a trend toward decreased survival in @entity1 with multifocal @entity1149 compared with @entity1 with stage I @entity1149 , this did not achieve statistical significance. Importantly, survival in these subgroups of @entity1 with stage IIIB or stage IV disease (stage determined solely on the basis of multifocal @entity1149 ) is better than the survival reported in the series that formed the foundation for these staging changes. These data support complete surgical resection of multifocal @entity2 in @entity1 with node-negative @entity1149 .
