b-3AR @entity25731 Polymorphism and 30-Minute Post-Challenge Plasma XXXX Levels in Obese @entity1 .

@entity1 @entity71289 @entity28 @entity2690 @entity534 @entity25731 @entity71288 @entity413
OBJECTIVE: In this study, we aimed to investigate the association of @entity25731 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity28 and related pathologies. METHODS: b-3AR gene @entity25731 genotyping was carried out in 251 @entity1 aged 6-18 years. Of these subjects, 130 were @entity28 (62 @entity1 ) and 121 were normal-weight (53 @entity1 ). In the @entity28 group, fasting lipids, @entity413 and @entity2690 levels were measured. Oral @entity413 tolerance test (OGTT) was performed in 75 of the @entity28 @entity1 . RESULTS: The frequency of @entity25731 genotype was similar in @entity28 and @entity28 @entity1 . In @entity28 @entity1 , relative body mass index, waist-to-hip ratio, serum lipid, @entity413 and @entity2690 levels, as well as homeostasis model assessment of @entity2690 resistance (HOMA-IR) scores were not different between @entity534 allele carriers ( @entity25731 and @entity71288 ) and noncarriers ( @entity71289 ). In 75 @entity28 @entity1 , OGTT results showed that @entity534 allele carriers had significantly higher 30-minute @entity413 levels (p=0.027). CONCLUSION: @entity25731 polymorphism of the b-3AR gene is not associated with @entity28 and waist-to-hip ratio in Turkish @entity1 . Although there were no relationships between the genotypes and lipid, @entity413 / @entity2690 levels or HOMA-IR, the presence of @entity25731 variant seemed to have an unfavorable influence on early @entity413 excursion after @entity413 loading.
