Assessment of Prognostic Value of "Neutrophil to Lymphocyte Ratio" and "Prognostic Nutritional Index" as a Sytemic Inflammatory Marker in XXXX .

@entity5 @entity1 @entity1149
BACKGROUND: Systemic inflammatory response was shown to play an important role in development and progression of many @entity5 types and different inflammation-based indices were used for determining prognosis. We aimed to investigate the prognostic effects of neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in @entity1 with @entity1149 ( @entity1149 ). MATERIALS AND METHODS: @entity1149 @entity1 diagnosed in our institution were retrospectively reviewed. Demographic and clinicopathologic characteristics were recorded. NLR and PNI was calculated before the application of any treatment. RESULTS: A total of 138 @entity1 were included in the study. @entity1 were divided into two groups according to NLR (<3.24 or >= 3.24) and PNI (<49.5 or >= 49.5). While median overall survival was 37.0 (95% CI 17.5-56.5) months in the group with low NLR, it was calculated as 10.0 (95%CI 5.0-15.0) months in the group with high NLR (p<0.0001). While median overall survival was 7.0 (95%CI 3.5-10.5) months in the group with low PNI, it was calculated as 33.0 (95% CI 15.5-50.4) months in the group with high PNI (p<0.0001). Stage, NLR and PNI levels were evaluated as independent risk factors for overall survival for all @entity1 in multivariate analysis (p<0.0001, p=0.04 and p<0.001, respectively). CONCLUSIONS: NLR (>= 3.24) and PNI (<49.5) at diagnosis is an independent marker of poor outcome in @entity1 with @entity1149 . NLR and PNI is an easily measured, reproducible prognostic tests that could be considered in @entity1149 @entity1 .
