Loss of telomerase activity may be a potential favorable prognostic marker in XXXX .

@entity1 @entity2215 @entity5 @entity1149 @entity2 @entity876 @entity105
Many @entity5 and immortal cells exhibit telomerase activity that stabilizes telomere lengths, possibly contributing to cell immortality and @entity105 . The aim of this study was to elucidate the clinicopathological relationship between telomerase activity and telomerase reverse transcriptase subunit ( @entity2215 ) status in @entity1149 . @entity2215 status in @entity1149 using telomeric repeat amplification protocol (TRAP) and RT-PCR assay, respectively. Telomerase activity and @entity2215 were detected in 85.7 and 80.3% of cancerous tissues, respectively. Telomerase activity does not correlate with clinicopathological variables. However, there was an association between @entity876 -correlated expression and @entity2215 negative status. @entity2 @entity1 without telomerase activity survived for a significantly longer period than those with telomerase activity. In addition, @entity2215 was not associated with the prognosis. @entity2215 expression did not correlate well with any clinical parameter. Reactivated telomerase activity may be a poor prognostic factor in NSCLCs.
