The XXXX : clinical aspects.

@entity1 @entity296 @entity712 @entity5122 @entity944 @entity384 @entity409 @entity999 @entity2554 @entity338 @entity1800 @entity18249 @entity943
The @entity384 are characterized by an increase in left ventricular internal dimensions without an appropriate increase in ventricular wall thickness. The @entity296 often goes unrecognized until the offending cause is no longer apparent. Although specific diagnoses and treatment can sometimes be established, the majority of cases are designated idiopathic but are believed to result from previous @entity1800 , @entity18249 , or abnormalities of the coronary microvasculature. Despite impaired contractility and @entity2554 , @entity409 may prevail for some time. Excessive fluid retention, neurohumoral activation, systemic vasoconstriction, and @entity338 promote progressive @entity5122 . The meticulous matching of diuretic and vasodilator therapy to specific hemodynamic goals, particularly the normalization of ventricular filling pressure, frequently allows restoration and maintenance of reasonable functional capacity even in @entity1 with severe @entity712 . Nevertheless, @entity944 due to @entity943 and occasionally to @entity999 remains a major threat. Prophylactic use of antiarrhythmic agents and anticoagulant therapy is not of proven efficacy. Cardiac transplantation results in significant improvement in life expectancy for @entity1 with dilated @entity712 but is available only to a relatively small number of @entity1 because of the limited donor supply. Accordingly, programs providing cardiac transplantation should be equally committed to providing optimal medical management that is the only option for the majority of @entity1 with @entity384 .
