Clinicopathological evaluation of @entity4536 in the mediterranean region of XXXX .

@entity1 @entity233 @entity738 @entity75 @entity1711 @entity232 @entity3594 @entity8286 @entity4536 @entity194 @entity6175 @entity272
OBJECTIVE: @entity232 , a chronic self-limited disease of the skin, is usually caused by Leishmania Tropica. It is endemic in Southeastern Anatolia. The definitive diagnosis depends on demonstration of the parasites by smear and culture or its identification in tissue section. This study aimed to evaluate clinical and histopathological @entity272 in @entity4536 cases in Antalya, @entity233 . MATERIAL AND METHOD: Our study included 28 @entity1 diagnosed with @entity4536 at the Pathology Department of Akdeniz University Medical Faculty. Histopathological sections were stained with @entity6175 - @entity1711 , Giemsa or Leishman for visual examination of cellular components by two dermatopathologists. The epidermal ( @entity3594 , @entity8286 , @entity194 , lymphocytic exocytosis) and dermal changes that may indicate lymphohistiocytic infiltration and @entity738 formation were investigated. The parasitic load was classified according to the modified Ridley's parasitic index. RESULTS: Out of 28 cases, 11 had hyperparakeratosis, 17 had orthokeratosis, 20 had @entity3594 , 4 had epidermal @entity194 , and 7 had exocytosis. Typical epithelioid cell @entity738 with giant cells and a rim of lymphocytes were present in 16 cases. Leishman-Donovan bodies were extremely rare in typical @entity75 . The other 12 cases showed lymphohistiositic infiltration, giant cells and prominent plasma cells. There were numerous Leishman-Donovan bodies in these lesions. CONCLUSION: We investigated the epidermal and dermal changes that would facilitate the histopathological diagnosis of @entity4536 in this study. We found that @entity194 , @entity3594 , and orthokeratosis were early stage indicators, while exocytosis, hyperparakeratosis, and @entity194 were indicative of late stage disease.
