XXXX -induced human antral injury is reduced by vodka pretreatment.

@entity1819 @entity117 @entity16 @entity344 @entity523 @entity35 @entity1281 @entity1068 @entity3137
Mild irritants have been shown to protect the @entity35 gastric mucosa against noxious agents. This study was designed to test the protective potential of low-dose @entity1068 against @entity117 ( @entity1281 ) -induced @entity1819 . Ten healthy volunteers who were nondrinkers and had normal baseline upper @entity344 participated in a randomized double-blind crossover study. Thirty minutes after either vodka (37.5 ml) in @entity523 juice or @entity523 juice alone, each subject took 975 mg ASA and then underwent endoscopy 1 hr later. The degree of @entity3137 was scored, and blood was taken for @entity1068 and salicylate levels. There was a washout interval of seven days between the two treatments. Endoscopic scores were analyzed using the sign test. After a single dose of ASA, @entity3137 was confined to the fundus and antrum, while the duodenum was minimally affected. A significant @entity16 was seen with @entity1068 pretreatment (P less than 0.05). The same trend was evident in the fundus but did not achieve statistical significance. Serum salicylate levels averaged 13.2 +/- 0.8 mg/100 ml and were not different between the two treatments. @entity1068 concentration ranged from 1.1 to 6.2 mmol/liter following the vodka drink and was 0 after the placebo.
