Ultrastructure of acute @entity3265 XXXX in the @entity1 lung.

@entity1 @entity137 @entity548 @entity3265 @entity4 @entity384 @entity133 @entity1129 @entity3655 @entity130
@entity1129 carrying anhydrous @entity3265 ( @entity3655 ) fell off a freeway, releasing a dense cloud of @entity3655 gas, killing several @entity1 . The driver was dead upon impact. To our knowledge, pulmonary @entity3655 @entity137 in @entity1 has not been studied previously by electron microscopy (EM). Therefore, in two cases, the paraffin-embedded tissue blocks of lung were deparaffinized and reembedded in plastic for 1-mu sections and EM examination. The lung tissue of a third case, the truck driver, was similarly processed as a control. Light-microscopic pulmonary findings in the acute @entity3655 deaths included denudation of the tracheobronchial epithelium, @entity4 , and marked @entity4 , @entity384 , and @entity548 . In contrast, in the truck driver's lungs, the bronchial epithelium was intact, and there was no gross odor of @entity3655 . Massive @entity548 in his lungs were attributed to @entity130 rather than @entity3655 inhalation. EM examination of the lungs of the truck driver showed no discernible toxic alterations in either the capillary endothelial cells or the Type I or II alveolar epithelial cells, and alveolar and capillary basement membranes were intact. In contrast, EM study of the lungs from two individuals dying acutely of @entity3655 inhalation showed marked swelling and imbitional @entity4 of Type I alveolar epithelial cells; however, @entity133 membranes and capillary endothelial cells appeared as usual. These electron-microscopic findings demonstrate the Type I epithelial cell to be the target cell of acute alveolar wall injury in @entity3655 inhalation.
