Transforming growth factor-12 polymorphism and XXXX .

@entity1 @entity32 @entity233 @entity1252 @entity2533 @entity6474 @entity1199 @entity792
OBJECTIVE: To determine whether @entity6474 ( @entity6474 ) gene polymorphism is associated with @entity1252 ( @entity1252 ) susceptibility. @entity2533 is a multifunctional family of cytokines important in tissue repair, @entity32 and immunoregulation. @entity1252 is thought to be a T cell dependent @entity792 with T cell dysfunction. Due to its known suppressive effects on @entity1199 dependent T cell growth, @entity6474 is considered to be a candidate @entity1252 susceptibility gene. Furthermore, @entity1252 has been linked with a region to which the @entity6474 gene has been mapped. METHODS: Association studies were performed in 3 case-control populations, from Spain. @entity233 , and UK, using a @entity6474 5'-untranslated region (5'-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in @entity6474 5'-UTR polymorphism allele frequencies between @entity1252 @entity1 and matched controls in the 3 populations studied. CONCLUSION: The 4 bp insertion polymorphism within the @entity6474 gene does not appear to be associated with @entity1252 . However, this does not rule out the possible involvement of @entity6474 in the disease pathogenesis.
