Central nervous system complications by XXXX : radiation schedule and treatment results.

@entity1 @entity706 @entity16 @entity615 @entity51 @entity1745 @entity978
During a 10-year period, 28 @entity1 with @entity1745 due to epidural @entity706 and 47 @entity1 with cerebral involvement of @entity706 were treated with radiation at our institution. Fifty-four percent of the @entity1 with @entity1745 had this complication at the time of initial presentation of the disease, whereas only 4% with cerebral involvement presented with CNS symptoms. Only one @entity1 had primary @entity706 solely located in the brain. Characteristically, a majority of the @entity1 with @entity615 several months before developing @entity16 . Because only one-third of the @entity1 had positive spine roentgenograms at the time of @entity1745 , a CT scan is suggested in @entity1 with @entity615 in order to verify a @entity706 . Thus @entity1745 may be avoided by early diagnosis and treatment. Among the @entity1 with @entity1745 , Hodgkin's and non-Hodgkin's histology were equally represented, whereas only 6% had @entity978 among the @entity1 with cerebral involvement of @entity706 . The response to treatment defined as improvement in @entity51 in the @entity1 with @entity1745 was approximately 90% in both the Hodgkin's and the non-Hodgkin's group. No difference in response was found among @entity1 who had laminectomy compared to @entity1 who did not. @entity1 receiving high dose, short-term treatment (5 Gy X 5-6) responded equally to @entity1 receiving low dose, long-term treatment (2 Gy X 18-20). The median survival from initiation of radiation therapy in @entity1 developing @entity1745 or cerebral involvement during relapse was 30 months. In @entity1 with @entity1745 at initial presentation of the disease, median survival had not been reached after 5 years. Among @entity1 with cerebral involvement 50% had improvement of @entity16 with no difference between @entity1 receiving high dose, short-term and @entity1 receiving low dose, long-term treatment. It is concluded that high dose, short-term irradiation is as effective as low dose treatment. Especially in @entity1 with @entity16 at relapse, this treatment schedule is preferred because of the extremely short survival of these @entity1 .
