Epithelial-Mesenchymal Transition Protein Expression in Basal Cell XXXX .

@entity5 @entity5962 @entity3546 @entity2277 @entity8945 @entity652 @entity420
UNASSIGNED: Basal cell @entity652 and @entity420 show marked histomorphologic similarity and are separated microscopically primarily by the invasive characteristics of the @entity420 . We wished to explore potential differences in the expression of epithelial-mesenchymal transition associated proteins in these two @entity5 types. A tissue microarray was constructed utilizing 29 basal cell @entity652 and 16 @entity420 . Immunohistochemical expression of @entity5962 , @entity3546 , @entity8945 and @entity2277 were investigated. Both @entity5 expressed all proteins in a relatively similar manner. Nuclear @entity3546 was essentially limited to the abluminal cell populations in both @entity5 types. @entity5962 was limited largely to luminal locations but was more prevalent in the @entity420 as compared to the @entity652 . Primarily abluminal expression for @entity2277 was seen, sometimes present in an apical dot-like pattern. Distinct populations of cellular expression of these four markers of epithelial mesenchymal transition were present but were similar in locations in both @entity5 with no patterns discerned to separate basal cell adenoma from @entity420 . Given these findings, the mechanisms by which @entity420 is able to invade while its counterpart, basal cell adenoma can not, may be more complex than in other @entity5 types.
