[Primary @entity706 with CD3- and XXXX + phenotype].

@entity1 @entity2940 @entity548 @entity706 @entity5 @entity1489 @entity11112 @entity381 @entity1893
A 73-year-old @entity1 was admitted to our hospital with @entity548 and high grade fever on Aug, 1992. Physical examination revealed a @entity5 in the nasopharyngeal cavity, generalized skin eruptions and three @entity5 on different subcutaneous lesions, @entity381 2 cm below the costal margin, and the enlargement of the right cervical and axillary lymph nodes. Biopsy of the nasopharyngeal and cutaneous @entity5 disclosed @entity1893 (WF: Diffuse small cleaved). Peripheral blood examination showed a WBC of 4,800/microliters with 10% blastoid cells. Bone marrow examination showed 60% blastoid cells which frequently appeared a hand mirror configuration had no azurophilic granules in the cytoplasm. Flow cytometic analysis of these cells in the bone marrow showed that they expressed @entity2940 (NKH-1) and Ia but not expressed T-cell antigens as well as B-cell antigens and myeloid cell antigens. Phenotype of subcutaneous @entity5 biopsy cells was similar to that of blastoid cells in the bone marrow. T-cell receptor gene ( @entity11112 and gamma) rearrangements in blastoid cells were not found. The @entity1 was treated with local radiotherapy to nasopharyngeal and @entity1489 , followed by chemotherapy. The @entity1 died of complication with @entity548 due to DIC. These results suggested that this @entity706 derived from NK cell.
