The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the XXXX Expression in the @entity6 .

@entity1552 @entity6 @entity1476 @entity1066 @entity2533
Aim. To investigate the dynamic changes on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in the @entity6 chronic refractory cutaneous @entity1066 after the autologous platelet-rich gel (APG) treatment. Methods. The study was developed at the @entity6 Care Centre, West China Hospital. The granulation tissues from the target wounds were taken before and within 15 days after APG application. The expression of @entity1476 and @entity1552 as well as @entity2533 ( @entity2533 ) in the granulation tissue was detected by q TR-PCR and IHC. The relationship between the expression level of @entity1476 and @entity1552 and their ratio and that of @entity2533 was analyzed. Results. The expression of @entity1476 (P < 0.05) was suppressed, and the expression of @entity1552 (P < 0.05) was promoted, while the ratio of @entity1476 / @entity1552 (P < 0.05) was decreased after APG treatments. The expression of @entity2533 had negative correlation with the ratio of @entity1476 / @entity1552 (P < 0.05) and positive correlation with the expression of @entity1552 (P < 0.05). Conclusions. APG treatment may suppress the expression of @entity1476 , promoting that of the @entity1552 in the @entity6 chronic refractory cutaneous wounds. @entity2533 may be related to these effects.
