Clinicopathological Factors and XXXX Prognosis in the Iranian Population: a Meta-analysis.

@entity5 @entity1 @entity356 @entity3
BACKGROUND: @entity356 is the most common @entity5 in the Iranian population. The aim of this study was to determine the effect of clinicopathological factors on prognosis by meta-analysis. MATERIALS AND METHODS: A literature search was conducted using MEDLINE, EMBASE and Cochrane library and extensive literature search using the Persian databases until February 2011. Prospective follow up studies with multivariate analysis of overall survival of the @entity1 with @entity356 were included in this review. The data were analyzed by CMA.2. Publication bias are checked by funnel plot and data are shown as Forest plots. RESULTS: From a total of 63 articles, 14 retrospective studies which examined 5 prognostic factors and involving 10,500 @entity1 were included. @entity5 size (>35mm) was the main significant factor predicting an unfavorable prognosis for the @entity1 with @entity356 (RR=1.829 , p<0.001) followed by presence of distant @entity3 (RR=1.607 , p<0.001), poor differentiation (RR=1.408 , p<0.001) and male sex (RR=1.194, p<0.001). Lymph node @entity3 (RR=1.058, p=0.698) and moderate differentiation (RR=0.836, p=0.043) were not statistically significant as prognostic factors. CONCLUSIONS: This meta-analysis suggests that @entity5 size>35mm, poor differentiation, presence of distant @entity3 and male gender are strongly associated with a poor prognosis in Iranian @entity1 with @entity356 .
