Risk factors for reduced corneal endothelial cell density before XXXX surgery.

@entity1 @entity231 @entity358 @entity2687 @entity2747 @entity130
PURPOSE: To assess the prevalence and risk factors for reduced endothelial cell density before @entity231 surgery. SETTING: Ohtsuki Eye Clinic, Sendai, Japan. METHODS: The records of 1304 eyes of 700 consecutive Japanese @entity1 who had @entity231 surgery from 1995 through 2000 were retrospectively reviewed. The incidence of reduced endothelial cell density to less than 2000 cells/mm(2) was calculated, and potential risk factors for the reduced density were analyzed using logistic regression analysis. RESULTS: The mean preoperative endothelial cell density was 2561.4 cells/mm(2) +/- 375.2 (SD). Reduced endothelial cell density was observed preoperatively in 123 eyes (9%) of 85 @entity1 (12%). In these @entity1 , factors responsible for the decrease were identified in 37 eyes (30%) of 28 (33%) @entity1 . Logistic regression analysis revealed that @entity2687 (P =.003), @entity2747 (P =.004), pseudoexfoliation (P =.031), and a history of @entity130 (P <.001) were significantly associated with reduced endothelial cell density. @entity231 and @entity358 were also significant risk factors (both P <.001). A subset quantitative comparison study showed that the mean endothelial cell densities in the subgroups of eyes with these risk factors were significantly less than those in a control group (P <.05, analysis of variance). CONCLUSIONS: Approximately 10% of @entity1 had reduced endothelial cell density before @entity231 surgery; the reason for the reduction was unknown in two thirds. @entity231 and @entity358 were significant risk factors for reduced density. Although the mechanisms are unknown, @entity231 surgeons should recognize that @entity1 with these risk factors may have a poor endothelial reserve.
