Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in @entity5093 -induced @entity410 in XXXX .

@entity17202 @entity410 @entity1865 @entity1432 @entity1234 @entity302 @entity35 @entity2195 @entity5093
BACKGROUND: An important role for oxidative stress, as a consequence of @entity302 , has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following @entity410 induced by @entity5093 ( @entity17202 ) was investigated in @entity35 . METHODS: The @entity35 were divided into five groups and treated: (1) Control (saline), (2) @entity17202 (90 mg/kg, i.p.), (3-5) three doses (100, 500 and 1000 mg/kg of @entity2195 ( @entity2195 ) before @entity17202 . Latencies to the first @entity410 ( @entity410 ) and the first generalized @entity410 (GTCS) were recorded. The cortical and hippocampal tissues were then removed for biochemical measurements. RESULTS: The extract significantly increased the @entity410 and GTCS latencies (P < 0.01, P < 0.001) following @entity17202 -induced @entity410 . The @entity1234 ( @entity1865 ) levels in both cortical and hippocampal tissues of @entity17202 group were significantly higher than those of the control animals (P < 0.001). Pretreatment with the extract prevented elevation of the @entity1865 levels (P < 0.010-P < 0.001). Following @entity17202 administration, a significant reduction in total @entity1432 groups was observed in both cortical and hippocampal tissues (P < 0.050). Pre-treatment with the 500 mg/kg of the extract caused a significant prevention of decreased in total @entity1432 concentration in the cortical tissues (P < 0.010). CONCLUSION: The present study showed that the hydroalcoholic extract of the aerial parts of C. sativum possess significant antioxidant and anticonvulsant activities.
