Microdialysis assessment of percutaneous penetration of XXXX after transdermal administration to hairless @entity35 and domestic pigs.

@entity1 @entity1707 @entity7988 @entity1421 @entity35
The study was performed to evaluate the percutaneous penetration of @entity7988 after transdermal administration using a microdialysis technique in @entity1707 , in comparison with @entity35 . @entity7988 release from patches was determined by analysis of the remaining drug content after application to hairless @entity35 and @entity1707 . Skin and knee joint penetration of @entity7988 was tested by microdialysis, and recovery was determined by retrodialysis. Residual rates in hairless @entity35 and @entity1707 were 68.1    1.6% and 81.7    4.4%, respectively, at 10h. The average recoveries of @entity7988 over 480 min in the skin and knee joint cases were 72.0    3.4% and 9.8    6.2% in @entity35 and 72.3    2.5% and 57.6    3.1% in @entity1707 , respectively. In @entity35 , @entity7988 was rapidly absorbed with transdermal administration, with C(max) values of 191.7    76.2 and 35.5    21.7 ng/mL and AUC(0-8h) values of 918.2    577.5 and 195.9    137.1 ngh/mL, respectively, for the skin and knee joint. The C(max) values for the @entity1707 were 20.9    18.5 and 3.7    3.0 ng/mL, with AUC(0-8h) values of 73.1    69.2 and 16.1    16.1 ngh/mL. @entity7988 concentrations within skin and knee joint of non-application sites in @entity35 and @entity1707 were less than 0.8 ng/mL. Transdermal administration of @entity7988 significantly reduced @entity1421 levels in the skin of the application site and showed a tendency for inhibition in the knee joint. We thus demonstrated that topical patches containing @entity7988 can deliver the drug through the skin and knee joint of @entity1707 and @entity35 via direct diffusion, and microdialysis data with the @entity1707 may be useful for the prediction of @entity1 tissue penetration of drugs with transdermal administration.
