Prognostic Value of Total Lesion Glycolysis by @entity419 PET/CT in Surgically Resected Stage IA XXXX .

@entity1 @entity419 @entity75 @entity5 @entity1149 @entity1349
UNASSIGNED: Despite the favorable prognosis of stage IA @entity1149 ( @entity1149 ), the disease recurs after complete surgical resection in 20%-30% of @entity1 . This study determined the prognostic value of various metabolic parameters of @entity419 PET/CT in surgically resected stage IA @entity1149 . METHODS: We retrospectively reviewed 248 @entity1 with stage IA @entity1149 who underwent lobectomy and complete lymph node dissection after PET/CT. A region of interest was drawn on the @entity75 , and metabolic indices such as @entity5 volume, maximum standardized uptake value (SUVmax), and total lesion glycolysis (TLG) were measured using an SUV cutoff of 2.5. RESULTS: The @entity1 included 134 @entity1 and 114 @entity1 , and the mean age was 63.03    10.01 y; 129 were stage T1a ( <=2 cm) and 119 were T1b (>2 cm). The median follow-up period was 36.6 mo. Recurrence took place in 15 @entity1 . The mean (  SD) SUVmax, @entity5 volume, and TLG were 4.55    3.75, 5.92    5.57, and 14.42    17.35, respectively. The cutoffs of SUVmax and TLG were 3.7 and 13.76, respectively. The 5-y @entity1349 ( @entity1349 ) was 95.1% in low-SUVmax @entity1 and 82.2% in high-SUVmax @entity1 (P = 0.02). The 5-y @entity1349 was 93.7% in low-TLG @entity1 and 78.3% in high-TLG @entity1 (P = 0.01). On multivariate analysis, TLG was a risk factor for @entity1349 (hazard ratio, 3.159; P = 0.040), but SUVmax showed marginal significance (P = 0.064). The concordance index of the TLG model was 0.676 (95% CI, 0.541-0.812). CONCLUSION: TLG was a significant prognostic factor for @entity1349 in @entity1 with stage IA @entity1149 .
