Meta-analysis comparing XXXX total dose intensity and survival.

@entity43 @entity1 @entity5 @entity3003 @entity900 @entity1349
OBJECTIVE: To determine the relationship between total dose intensity (TDI) of @entity900 / @entity3003 , total dose intensity of all chemotherapy drugs (GDI) and @entity1349 ( @entity1349 ) in @entity43 @entity1 . METHODS: Over 700 studies from the English literature were reviewed. Prospective clinical trials that had at least one arm treating @entity1 with @entity900 / @entity3003 and provided data on both @entity1349 and dose and schedule of chemotherapy were included. Dose intensity (DI), TDI, and GDI were calculated for each study arm. To explore possible relationships, several linear regression models were fitted with @entity1349 as the dependent variable and DI, TDI, GDI, and other known prognostic factors as the independent variables. RESULTS: Sixty-one study arms were analyzed including 4118 @entity1 . No significant correlation was found between DI and TDI of @entity900 and @entity1349 (P = 0.90 and P = 0.11 respectively). Of the 10 variables tested, proportion of @entity1 optimally debulked (%OD), proportion of @entity5 , and GDI were found to have a significant correlation to @entity1349 . All studies with a GDI less than 20 and %OD < 20 had a @entity1349 less than 20 months. On the other hand 77% of studies have a @entity1349 greater than 20 months when GDI is > 20 and %OD > 20%. We found single-agent chemotherapy had the worst outcome and there was very little difference between two or more drugs for percentage of studies with > 20 months @entity1349 , (56.5% vs 63.3% respectively). CONCLUSIONS: From this meta-analysis we believe that both GDI and %OD are important factors that determine outcome in terms of @entity1349 .
