Feasibility of a concanavalin A-peroxidase labeling method to detect cancerous and XXXX of the uterine cervix.

@entity1 @entity5 @entity168 @entity957 @entity189 @entity1613 @entity1141
For the detection of cancerous and @entity1613 in cervical cytopathology, the feasibility of a concanavalin A-peroxidase labeling procedure was tested and compared with the Papanicolaou method. To this end, the percentage of labeled flattened epithelial cells with a morphologically normal appearance present in cervical cell suspensions was determined. It was found that the mean labeling percentage of the control group was 71% ( @entity168 , 11%). The means for mild, moderate, and severe @entity1141 groups were, respectively, 54% ( @entity168 , 19%), 48% ( @entity168 , 13%), and 44% ( @entity168 , 16%). The mean for the @entity189 in situ group was 32% ( @entity168 ,11%), and for the @entity957 group 16% ( @entity168 , 5%). It appeared that the labeling percentage gradually decreases with increasing atypia of the epithelium as confirmed by histological observation. A complete dissimilarity was found between healthy individuals and @entity5 @entity1 . In a follow-up study it was found that the mean labeling percentage did not alter in cases of an unchanged stage of disease. A reestablishment of the normal concanavalin A-peroxidase labeling percentage often appeared once the @entity5 was treated. In conclusion, the concanavalin A-peroxidase labeling method can be considered as a supplementary technique to the Papanicolaou method for the early detection of cervical @entity5 . It reduces the effect of sampling and screening errors of the Papanicolaou method, and it allows a more objective cytological diagnosis. In addition, it may possess prognostic significance.
