Preoperative administration of intravenous XXXX axetil reduces postoperative pain for spinal fusion surgery.

@entity1 @entity86 @entity158 @entity1286 @entity8726
PURPOSE: The aim of the study was to investigate @entity86 and the opioid-sparing effect of the preoperative administration of intravenous @entity8726 axetil in @entity1 undergoing spinal fusion surgery. METHODS: Thirty-six @entity1 were randomly allocated into one of three groups. Group A received preoperative @entity8726 axetil, 1 mg x kg(-1). Group B received postoperative @entity8726 axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous @entity1286 via a @entity1 -controlled analgesia device for @entity86 . The @entity158 score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the @entity1286 requirement was recorded during the study period. RESULTS: VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative @entity1286 consumption in group A was significantly lower than that in groups B and C at T(0) to T(3). CONCLUSION: As compared with postoperative administration, preoperative administration of intravenous @entity8726 axetil provides better @entity86 and an opioid-sparing effect in @entity1 undergoing spinal fusion surgery under general anesthesia.
