The influence of bypass temperature on the systemic inflammatory response and XXXX after pediatric open surgery: a randomized trial.

@entity1 @entity32 @entity2332 @entity190 @entity86 @entity1850 @entity299 @entity130
OBJECTIVE: Systemic cooling for cardiopulmonary bypass is widely used to attenuate the @entity1850 and @entity130 in @entity1 after open surgery. We compared the effects of moderate (24   C) and mild (34   C) @entity2332 during bypass on markers of the @entity1850 and @entity130 , and on clinical outcome after corrective surgery for @entity299 . METHODS: Sixty-six @entity1 (mean age, 6.8    5.7 months; mean weight, 6.2    2.3 kg) were randomized to 24   C or 34   C bypass temperature during cardiac surgery. Perfusion strategies were otherwise strictly identical. Clinical data and blood samples were collected before bypass, 5 minutes after aortic crossclamp release, and 4, 24, and 48 hours after bypass. @entity1 were followed up until discharge from the hospital. RESULTS: In the 54 @entity1 with outcome data, bypass temperature did not influence the duration of mechanical ventilation between the 24   C group and the 34   C group (median [interquartile range] 22 [13-40] hours vs 14 [8-40] hours, P = .14), intensive care unit stay (43 [24-49] hours vs 29 [23-47] hours, P = .79), @entity190 (29 [20-38] mL/kg vs 23 [13-38] mL/kg, P = .36), or incidence of @entity86 (9% vs 11%, P = 1.0). There was no evidence of an influence of bypass temperature on the markers of acute @entity32 , innate immune response, @entity130 , coagulation, or hemodynamics. CONCLUSIONS: There is no evidence that the @entity1850 and @entity130 after pediatric open surgery are influenced by bypass temperature. The routine use of hypothermic bypass may not be warranted in the pediatric population.
