Comparison of 7.5% XXXX /6% dextran-70 resuscitation of @entity548 between euhydrated and dehydrated @entity742 .

@entity22945 @entity64 @entity742 @entity548 @entity1219 @entity1372 @entity4372 @entity551
7.5% @entity1219 /6% dextran-70 ( @entity22945 ) has been shown to be an effective, small volume resuscitation fluid following @entity548 ( @entity548 ) in euhydrated (E) @entity742 . However, there is controversy whether @entity4372 solutions would be effective in dehydrated (D) animals. Therefore, we used two groups (E and 4 days D) of chronically instrumented ewes to evaluate the responses to @entity22945 following @entity548 . All @entity742 were bled and maintained at 50 mmHg @entity551 ( @entity551 ) for 2 h, then resuscitated with a 4 mL/kg bolus of @entity22945 . Dehydration did not affect baseline @entity551 , heart rate (HR), or total peripheral resistance (TPR), whereas cardiac output (CO: E, 5.28 +/- .31; D, 4.00 +/- .31 L/min), @entity64 volume (SV: E, 61 +/- 4; D, 44 +/- 4 mL/beat), urine flow rate (V: E, .51 +/- .11; D, .34 +/- .07 mL/min), and @entity1372 excretion (UNa V: E, 22 +/- 8; D, 6 +/- 2 microEq/min) were reduced and plasma @entity1372 (PNa: E, 150 +/- 3; D, 157 +/- 2 mEq/L) and protein (PTP E, 7.8 +/- .1; D, 8.8 +/- .6 g/dL) were elevated. The only difference between groups during @entity548 were HR (E, 98 +/- 8; D, 150 +/- 17 bpm), SV (E, 31 +/- 3; D, 14 +/- 2), and TPR (E, 23 +/- 2; D, 32 +/- 3). Resuscitation with @entity22945 restored @entity551 (E, 92 +/- 3; D, 92 +/- 2), CO (E, 6.2 +/- .3; D, 4.2 +/- .2), and TPR (E, 15 +/- 1; D, 23 +/- 1) to baseline values. SV was increased above @entity548 values but was not restored to baseline values in either group (E, 50 +/- 7; D, 27 +/- 3). HR increased further following @entity22945 (E, 143 +/- 11; D, 158 +/- 5). PNa was raised 10 and 16 mEq/L in the E and @entity742 , respectively, following @entity22945 infusion, but no adverse effects associated with elevated PNa were observed in either group. Thus, @entity22945 was effective in restoring @entity551 , CO, and TPR to baseline values in @entity742 but it was at the expense of a lower SV and a higher HR than in E @entity742 .
