XXXX delineation using multiparametric magnetic resonance imaging: Inter-observer variability and pathology validation.

@entity5 @entity1 @entity263
BACKGROUND AND PURPOSE: Boosting the dose to the largest (dominant) lesion in radiotherapy of @entity263 may improve treatment outcome. The success of this approach relies on the detection and delineation of @entity5 . The agreement among teams of radiation oncologists and radiologists delineating lesions on multiparametric magnetic resonance imaging (mp-MRI) was assessed by measuring the distances between observer contours. The accuracy of detection and delineation was determined using whole-mount histopathology specimens as reference. MATERIAL AND METHODS: Six observer teams delineated @entity5 on mp-MRI of 20 @entity263 @entity1 who underwent a prostatectomy. To assess the inter-observer agreement, the inter-observer standard deviation (SD) of the contours was calculated for @entity5 sites which were identified by all teams. RESULTS: Eighteen of 89 lesions were identified by all teams, all were dominant lesions. The median histological volume of these was 2.4cm(3). The median inter-observer SD of the delineations was 0.23cm. Sixty-six of 69 satellites were missed by all teams. CONCLUSION: Since all teams identify most dominant lesions, dose escalation to the dominant lesion is feasible. Sufficient dose to the whole prostate may need to be maintained to prevent under treatment of smaller lesions and undetected parts of larger lesions.
