Prevalence of XXXX @entity1353 in the general population: the HypnoLaus study.

@entity1 @entity308 @entity101 @entity6 @entity1353 @entity74 @entity65 @entity209 @entity25
BACKGROUND: @entity25 @entity1353 is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for @entity65 . Taking into account improvements in recording techniques and new criteria used to define respiratory events, we aimed to assess the prevalence of @entity25 @entity1353 and associated clinical features in a large population-based sample. METHODS: Between Sept 1, 2009, and June 30, 2013, we did a population-based study (HypnoLaus) in Lausanne, Switzerland. We invited a cohort of 3043 consecutive @entity1 of the CoLaus/PsyCoLaus study to take part. Polysomnography data from 2121 @entity1 were included in the final analysis. 1024 (48%) @entity1 were @entity1 , with a median age of 57 years (IQR 49-68, range 40-85) and mean body-mass index (BMI) of 25  6 kg/m(2) (SD 4  1). @entity1 underwent complete polysomnographic recordings at home and had extensive phenotyping for @entity6 , @entity101 , @entity209 , and @entity308 . The primary outcome was prevalence of @entity25 @entity1353 , assessed by the apnoea-hypopnoea index. FINDINGS: The median apnoea-hypopnoea index was 6  9 events per h (IQR 2  7-14  1) in @entity1 and 14  9 per h (7  2-27  1) in @entity1 . The prevalence of moderate-to-severe @entity25 @entity1353 (>= 15 events per h) was 23  4% (95% CI 20  9-26  0) in @entity1 and 49  7% (46  6-52  8) in @entity1 . After multivariable adjustment, the upper quartile for the apnoea-hypopnoea index (>20  6 events per h) was associated independently with the presence of @entity101 (odds ratio 1  60, 95% CI 1  14-2  26; p=0  0292 for trend across severity quartiles), @entity6 (2  00, 1  05-3  99; p=0  0467), @entity209 (2  80, 1  86-4  29; p<0  0001), and @entity308 (1  92, 1  01-3  64; p=0  0292). INTERPRETATION: The high prevalence of @entity25 @entity1353 recorded in our population-based sample might be attributable to the increased sensitivity of current recording techniques and scoring criteria. These results suggest that @entity25 @entity1353 is highly prevalent, with important public health outcomes, and that the @entity74 should be revised. FUNDING: Faculty of Biology and Medicine of Lausanne, Lausanne University Hospital, Swiss National Science Foundation, Leenaards Foundation, GlaxoSmithKline, Ligue Pulmonaire Vaudoise.
