[Effect of hepatic resection on development of liver XXXX ].

@entity5 @entity35 @entity19 @entity3
In the early stages of @entity3 , development of the disease is dependent on growth factors produced by the host. There are clinical situations associated with an increase in these factors, such as partial resection of metastasized liver. Given the important role of hepatotrophic factors in liver regeneration, we have studied the effect of partial hepatectomy on the development of residual micrometastases in the liver, and on the @entity5 as a whole. We used a @entity19 model in which a rabdomiosarcoma was established by subcutaneous inoculation of syngeneic @entity5 cells in male Wag @entity35 . Subsequently, the @entity5 was resected and/or a 40% hepatectomy was performed. The effect of these two surgical procedures on the @entity5 process was analyzed on the 25th and 35th days post-inoculation, and the percentage of regenerating hepatocytes was assessed. Both the tumorectomy and liver resection, when not combined, produced an increase in regional adenopathies without modifying the evolution of @entity3 in the liver. However, when @entity5 excision and partial hepatectomy were performed simultaneously, there was a net increase in the metastatic process. In addition to a rapid spread of the disease (lung, mediastinum, retroperitoneum), the number of liver metastases increased by 300%. This development coincided with a steep rise in the percentage of regenerating hepatocytes, which nearly doubled that of the group subjected only to liver resection. We conclude that liver resection, alone or combined with excision of the @entity5 , may enhance @entity5 progression, both locally and at the metastasic level.
