Treg responses are associated with PM2.5-induced exacerbation of XXXX .

@entity32 @entity308 @entity19 @entity641 @entity777 @entity2401 @entity299 @entity3744 @entity637
UNASSIGNED: The adverse cardiovascular events induced by ambient fine particles (PM2.5) are paid more attention in the world. The current study was conducted to explore the mechanisms of T regulatory cells (Treg) responses in PM2.5-induced exacerbation of @entity2401 . The male BALB/c @entity19 were administered an intratracheal (i.t.) instillation of 10   mg/kg b.w. PM2.5 suspension. Twenty-four hours later, the @entity19 were injected intraperitoneally (i.p.) with 100    l of coxsackievirus B3 (CVB3) diluted in Eagle's minimal essential medium (EMEM). Seven days after the treatment, serum, splenetic, and cardiac tissues were examined. The results showed that pre-exposure to PM2.5 aggravated the @entity299 in the CVB3-infected @entity19 along with an increase of Treg cells in the spleen. The mRNA expressions of @entity777 ( @entity777 ), @entity637 , @entity641 ( @entity641 ), and @entity3744 were up-regulated in the PM2.5-pretreated @entity19 than that in the CVB3-treated @entity19 . Similar results were found in the sera. In addition, compared with the CVB3-treated @entity19 , the cardiac protein expression of @entity641 increased in the PM2.5-pretreated @entity19 . These results demonstrated that preexposure to PM2.5 exacerbated virus-induced @entity2401 possibly through the @entity308 of the immune response and increase of @entity32 in myocardium through the Treg responses.
