The alkalinizing effects of metabolizable bases in the healthy XXXX .

@entity3747 @entity4388 @entity4958 @entity1792 @entity4919 @entity598 @entity1372 @entity3157 @entity6853 @entity880 @entity460 @entity12742 @entity2827 @entity291 @entity5097
The alkalinizing effect of @entity1792 , @entity598 , @entity4919 , @entity12742 , L and DL- @entity880 were compared in healthy neonatal @entity291 . The @entity291 were infused for a 3.5 hour period with 150 mmol/L solutions of the @entity1372 salts of the various bases. Blood pH, base excess, and metabolite concentrations were measured and the responses compared with @entity4388 and @entity2827 infusion. @entity12742 and @entity6853 had poor alkalinizing abilities and accumulated in blood during infusion suggesting that they are poorly metabolized by the @entity291 . @entity598 , @entity5097 and @entity4919 had alkalinizing effects similar to @entity3157 , although those of @entity598 had a slightly better alkalinizing effect than @entity5097 . @entity598 was more effectively metabolized because blood @entity598 concentrations were lower than @entity5097 concentrations. There was a tendency for a small improvement in metabolism of @entity598 and @entity880 with age. @entity4958 infusion produced signs of @entity3747 , presumably because it removed ionized @entity460 from the circulation. @entity12742 , @entity6853 and @entity1792 are unsuitable for use as alkalinizing agents in intravenous fluids. @entity4919 , @entity598 and @entity5097 are all good alkalinizing agents in healthy @entity291 but will not be as effective in situations where tissue metabolism is impaired.
