Acquired XXXX : An Underestimated and Potentially Important Laboratory Finding.

@entity1 @entity712 @entity295 @entity2067 @entity5 @entity114 @entity17454 @entity5630 @entity281 @entity1985
OBJECTIVE: To investigate all cases of isolated factor VII (FVII) deficiency as gathered from personal files or by a PubMed search. @entity1 AND METHODS: Personal files dealing with @entity1 studied in Padua during the years 1970 to 2010 were reevaluated. The PubMed search was time unlimited and was carried on 2 occasions during 2014. Cross-checking of the references, listed in every article, was also carried out to avoid omissions. Inclusion criteria were isolated FVII defect of less than 40% of normal, negative coagulation pattern in the family, normal level of other @entity2067 -dependent clotting factors, and normalization of the clotting factor after the therapeutic procedures, unless the @entity1 died. RESULTS: Twenty-nine @entity1 met the inclusion criteria (18 male and 9 female, in 2 cases gender was unreported). This number included 1 personal case. Mean age was 37.9 (range 3-80). Underlying diseases were the following: @entity5 , @entity281 , polytrauma, @entity114 administration, @entity1985 Wiskott @entity17454 , and @entity712 (1 case, each); 2 @entity1 had no underlying disease. Bleeding was variable but usually mild. There were 11 fatalities. CONCLUSIONS: Isolated @entity5630 is a rare defect, which appears to be a finding associated with several morbid conditions, especially @entity295 and @entity5 . This indicates the need for a careful investigation of even a mild prolongation of prothrombin time, especially when fibrinogen and partial thromboplastin time are normal.
