Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to XXXX .

@entity652 @entity11559 @entity10523 @entity3930 @entity4336 @entity245 @entity600 @entity35 @entity393 @entity528 @entity15523
In utero exposure of male @entity35 to the antiandrogen @entity15523 ( @entity11559 ) leads to @entity393 (AGD) on postnatal day (PND) 1, increased areolae retention on PND 13, @entity600 in the male reproductive tract, and histologic testicular lesions including marked @entity528 and a low incidence of Leydig cell (LC) @entity652 on PND 90. One objective of this study was to determine the incidence and persistence of decreased AGD, increased areolae retention, and LC @entity652 in adult @entity35 following in utero @entity11559 exposure. A second objective was to determine whether AGD and areolae retention during the early postnatal period are associated with lesions in the male reproductive tract. Pregnant Crl:CD(SD)BR @entity35 were gavaged with @entity4336 oil or @entity11559 at 100 or 500 mg/kg/day, 10 dams per group. Three replicates of @entity35 (n = 30 @entity35 per replicate) were exposed from gestation day 12 to 21 and the male offspring allowed to mature to 6, 12, or 18 months of age. Gross @entity600 in the male reproductive tract and histologic lesions in the testes were similar to those previously described. However, @entity10523 , a lesion of proliferating LCs and aberrant tubules that has not been previously described in @entity11559 -exposed testes, was diagnosed. The incidence of this lesion was approximately 20% unilateral and 7-18% bilateral in the high-dose group and was similar among all ages examined, implicating a developmental alteration rather than an age-related change. AGD and areolae retention were found to be permanent changes following in utero exposure to 500 mg/kg/day of @entity11559 . Decreased AGD was a sensitive predictor of lesions in the male reproductive tract, relatively small changes in AGD were associated with a significant incidence of @entity3930 . In utero @entity11559 exposure induced @entity245 , some of which would have been diagnosed as LC @entity652 by the morphological criteria set forth by the Society of Toxicologic Pathology. However, these lesions were dissimilar to traditional LC @entity652 as the LCs were poorly differentiated and the lesions contained aberrant seminiferous tubules. While the morphology and incidence of this @entity11559 -induced @entity245 has been fully characterized by this study, the detailed pathogenesis warrants further investigation.
