Comparison between the efficacy and safety of platelet-rich plasma vs. microdermabrasion in the treatment of XXXX : clinical and histopathological study.

@entity1 @entity1711 @entity1710 @entity29694
UNASSIGNED: Striae distensae is a challenging cosmetic problem for which various treatment modalities have been applied. To compare between the efficacy and tolerability of intradermal injection of autologous platelet-rich plasma (PRP) vs. microdermabrasion in the treatment of @entity29694 . Sixty-eight @entity1 with @entity29694 were randomly assigned to three groups according to therapeutic modalities. @entity1 of group I were treated by intradermal injection of PRP alone, @entity1 of group II were treated with microdermabrasion alone, and @entity1 of group III were treated with combination of intradermal PRP and microdermabrasion in the same session. Each @entity1 underwent maximum of six sessions at 2-week interval. Skin biopsies were taken from some @entity1 at baseline, and 3  months after the last sessions stained with @entity1710 and @entity1711 stain, Masson trichrome, orceun, and Van Gieson stains to study of histopathological changes and efficacy of treatment. There was significant clinical improvement of @entity29694 in @entity1 treated with PRP injection and @entity1 treated with combination of PRP and microdermabrasion when compared with @entity1 treated with microdermabrasion. However, combination of PRP and microdermabrasion in the same session showed better results in short duration. Collagen and elastic fibers were markedly increased in the dermis at the end of treatment sessions. Platelet-rich plasma alone is more effective than microdermabrasion alone in the treatment of @entity29694 , but it is better to use the combination of both for more and rapid efficacy. However, each one of them is well tolerated by the @entity1 , safe and cost effective.
