Mapping common deleted regions on 5p15 in XXXX and their occurrence in @entity1613 .

@entity5 @entity2622 @entity1799 @entity1613 @entity105 @entity3146
BACKGROUND: Previous studies have shown that the short arm of chromosome 5 (5p) exhibit frequent genetic changes in invasive @entity2622 ( @entity2622 ), and that these changes arise early during the @entity105 , in @entity1613 . These data therefore suggest that @entity5 suppressor genes located on 5p is associated with the development of @entity2622 . However, the precise location of 5p deletions is not known. RESULTS: We performed a detailed deletion mapping of 5p in 60 cases of invasive @entity2622 . We found that 60% of the @entity5 exhibit a 5p loss of heterozygosity (LOH). The patterns of LOH allowed us to identify two minimal regions of deletions, one at 5p15.3 spanning a 5.5 cM genetic distance and a second site of 7 cM at 5p15.2-15.3. In addition, we also identified 5p deletions in 16% lesions of high-grade @entity3146 ( @entity3146 ). 5p LOH was found in 63% of @entity1799 positive @entity5 , while only 33% @entity5 with other HPV-types had 5p LOH. The differences in frequency of 5p LOH between @entity5 harboring @entity1799 in combination with other @entity5 harboring @entity1799 DNA alone were significantly higher, suggesting a synergistic effect of high-risk types in causing genomic instability. CONCLUSION: These findings implicate the presence of @entity5 suppressor gene(s) on 5p relevant to @entity2622 tumorigenesis.
