Distribution and burden of newly detected coronary artery @entity460 : Results from the Multi-Ethnic Study of XXXX .

@entity1 @entity101 @entity28 @entity6 @entity460 @entity731
BACKGROUND: The transition from no coronary artery @entity460 (CAC) to detectable CAC is important, as even mild CAC is associated with increased cardiovascular events. We sought to characterize the anatomic distribution and burden of newly detectable CAC over 10-year follow-up. METHODS: We evaluated 3112 @entity1 (mean age, 58  years; 64% female) with baseline CAC  = 0 from the Multi-Ethnic Study of @entity731 . @entity1 underwent repeat CAC testing at different time intervals (between 2-10  years after baseline) per the Multi-Ethnic Study of @entity731 protocol. Among @entity1 who developed CAC on a follow-up scan, we used logistic regression and marginal probability modeling to describe the coronary distribution and burden of new CAC by age, sex, and race after adjustment for cardiovascular risk factors and time to detection. RESULTS: A total of 1125 @entity1 developed detectable CAC during follow-up with a mean time to detection of 6.1    3  years. New CAC was most commonly isolated to 1 vessel (72% of @entity1 ), with the left anterior descending artery (44% of total) most commonly affected followed by the right coronary (12%), left circumflex (10%), and left main (6%). These patterns were similar across age, sex, and race. In multivariate models, residual predictors of multivessel CAC (28% of total) included male sex, African American or Hispanic race, @entity101 , @entity28 , and @entity6 . At the first detection of CAC >0, burden was usually low with median Agatston CAC score of 7.1 and <5% with CAC scores >100. CONCLUSION: New-onset CAC most commonly involves just 1 vessel, occurs in the left anterior descending artery, and has low CAC burden. New CAC can be detected at an early stage when aggressive preventive strategies may provide benefit.
