Functional connectivity of brain regions for self- and other-evaluation in XXXX , adolescents and adults with autism.

@entity1 @entity72604 @entity72
UNASSIGNED: Developing strong ties between oneself and others lays the foundation for developing social competence. Neuroimaging studies have consistently identified specific cortical midline regions activated during evaluative judgments about the self and others. Individuals with @entity72 ( @entity72 ) process self-relevant information differently from their peers, both behaviorally and at the neural level. We compared resting-state functional connectivity (rsFC) of regions involved in self-referential (e.g. medial prefrontal cortex; mPFC) and other-referential (e.g. posterior cingulate cortex; @entity72604 ) processing between neurotypical individuals and individuals with @entity72 in three age cohorts using regions of interest (ROIs) identified through an activation likelihood estimation meta-analysis. Typically developing @entity1 demonstrated greater connectivity within the midline self- and other-referential networks compared with age-matched @entity1 with @entity72 . No group differences in rsFC of mPFC or @entity72604 emerged between typically developing adolescents and adolescents with @entity72 . Neurotypical adults exhibited stronger rsFC of the @entity72604 with orbitofrontal cortex compared with adults with @entity72 . Developmental differences in functional connectivity between areas underlying self- and other-referential thought may explain altered developmental trajectories in the understanding of self and others in individuals with @entity72 .
