Stachys sieboldii (Labiatae, Chorogi) Protects against @entity4207 Associated with XXXX .

@entity5591 @entity2414 @entity2806 @entity19 @entity1294 @entity73 @entity273 @entity4207 @entity195 @entity432 @entity4044 @entity528 @entity413 @entity2359
Stachys sieboldii (Labiatae; Chinese artichoke, a tuber), "chorogi" in Japanese, has been extensively used in folk medicine, and has a number of pharmacological properties, including antioxidative activity. However, few studies have examined the neuroprotective effects of S. sieboldii tuber extract (chorogi extract), and it remains unknown whether the extract can alleviate @entity4207 associated with @entity1294 or @entity195 . Therefore, in this study, we investigated the neuroprotective effects of chorogi extract, and examined its protection against @entity4207 using @entity4044 leaf extract ( @entity4044 extract) as a positive control. @entity19 were subjected to bilateral carotid @entity432 (BCAO) for 30 min. Oral administration of chorogi extract or @entity4044 extract significantly reduced post-ischemic @entity413 intolerance on day 1 and @entity528 including @entity2414 on day 3 after BCAO, compared with the vehicle-treated group. Neither herbal medicine affected locomotor activity. Furthermore, neither significantly alleviated @entity5591 -induced @entity73 . In primary neurons, neuronal survival rate was significantly reduced by @entity273 treatment. This @entity273 -induced @entity2359 was significantly suppressed by chorogi extract and @entity4044 extract. Taken together, our findings suggest that chorogi extract as well as @entity4044 extract can protect against @entity4207 associated with @entity2806 through an antioxidative mechanism.
