Total Knee Replacement as a XXXX Outcome: Predictors Derived from a 4-Year Long-Term Observation following a Randomized Clinical Trial Using Chondroitin Sulfate.

@entity1 @entity626 @entity571 @entity158 @entity236 @entity393 @entity1851
OBJECTIVE: To predict, using clinical and qMRI data, the incidence of total knee replacement (TKR) during the long-term follow-up of @entity626 ( @entity571 ) @entity1 who formerly received chondroitin sulfate (CS) or placebo treatment. DESIGN: A post hoc intention-to-treat analysis to evaluate the incidence of TKR was done on knee @entity571 @entity1 who had participated in a 12-month trial evaluating the impact of CS (800 mg/d) versus placebo for 6 months, followed by a 6-month open-phase in which all @entity1 received CS. Additionally, the clinical and qMRI predictors of TKR were determined. RESULTS: Thirteen TKRs were performed in the population after a 4-year follow-up. More TKRs were performed in the placebo group than in the CS group (69% vs. 31%, P = 0.150, logistic regression). The statistically significant predictors of TKRs were, at baseline, higher WOMAC @entity158 and function scores, presence of @entity236 ( @entity236 ), and higher @entity1851 levels. Loss of medial cartilage volume and increase in WOMAC @entity158 and function at one-year were also predictors of TKR. Multivariate analyses revealed that baseline presence of BML and higher WOMAC @entity158 score were independent predictors. Time to occurrence of the TKR also favored the CS group versus placebo (log-rank, P = 0.094). CONCLUSION: Symptoms such as knee @entity158 and function, presence of BML, and cartilage @entity393 predict the long-term occurrence of a "hard" outcome such as TKR.
