Immune microenvironment as a factor of XXXX progression.

@entity31653 @entity7571 @entity172 @entity1782 @entity4041 @entity0 @entity588 @entity1420 @entity5 @entity1457 @entity5962 @entity2281 @entity1722 @entity479
BACKGROUND: The rate of progression of the disease depends on various factors and the @entity5 microenvironment takes not the last place among them. One part of researchers argues that the presence of @entity5 -infiltrating leukocytes serves as a favorable marker of the disease. There exists a completely different point of view on the matter. The investigation of the effects of the inflammatory infiltration on the course of @entity0 process. METHODS: We found a pronounced inflammatory infiltration in the @entity5 microenvironment in 24 cases. Nineteen cases of IDC without inflammatory infiltration were used as a control group. Immunohistochemical reaction showed expression of @entity1782 , PR, @entity1722 / @entity1722 , @entity5962 , @entity31653 , @entity588 , CD3, @entity7571 , @entity2281 and Myeloperoxidase receptors. Mathematical calculations were done using Microsoft Excel 2010 with 12.0.5 Attestat option. RESULTS: We have determined five variants of immune microenvironment: interstitial, trabecular, nodular, diffuse and mixed. We have established a direct correlation between the expression of @entity1782 and PR and indirect correlation between the receptors of @entity479 hormones and @entity1722 /neo in both groups of @entity0 . @entity1722 /neo positive @entity5 in 100% of cases were accompanied by the presence of @entity1457 proteins. There was a combination of @entity588 presence with the @entity479 receptors expression in 90 % of cases. There was found the indirect correlation between the presence of B lymphocytes and expression of @entity479 receptors. CONCLUSIONS: The presence of B lymphocytes in an inflammatory infiltrate leads to the disappearance of @entity172 receptors and @entity1420 receptors. It provokes the accumulation of @entity4041 in a cell. It contributes to the stabilization of @entity1722 / @entity1722 receptors and most proteins that promote @entity5 progression. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1362330168161694.
