Total, Dietary, and Supplemental XXXX Intake and Risk of  Incident @entity1290 .

@entity620 @entity1 @entity1290 @entity6662
BACKGROUND: Previous studies of @entity620 and @entity1290 were conducted mostly in @entity1 and either reported disparate results for supplemental and dietary @entity620 or did not examine dietary @entity620 . STUDY DESIGN: Prospective cohort analysis. SETTING _ @entity1 : 156,735 @entity1 in the Nurses' Health Study (NHS) I and II and 40,536 @entity1 in the Health Professionals Follow-up Study (HPFS). PREDICTOR: Total, dietary, and supplemental @entity620 intake, adjusted for age, body mass index, @entity6662 use, and dietary factors. OUTCOMES: Incident @entity1290 . RESULTS: During a median follow-up of 11.3 to 11.7 years, 6,245 incident @entity1290 were identified. After multivariable adjustment, total @entity620 intake (<90 [reference], 90-249, 250-499, 500-999, and  >= 1,000mg/d) was not significantly associated with risk for @entity1290 among @entity1 , but was among @entity1 (HRs of 1.00 [reference], 1.19 [95% CI, 0.99-1.46], 1.15 [95% CI, 0.93-1.42], 1.29 [95% CI, 1.04-1.60], and 1.43 [95% CI, 1.15-1.79], respectively; P for trend  = 0.005). Median total @entity620 intake for the 500- to 999-mg/d category was    700mg/d. Supplemental @entity620 intake (no use [reference],  <500, 500-999, and  >= 1,000mg/d) was not significantly associated with risk for @entity1290 among @entity1 , but was among @entity1 (HR, 1.19 [95% CI, 1.01-1.40] for  >= 1,000mg/d; P for trend  = 0.001). Dietary @entity620 intake was not associated with stones among @entity1 or @entity1 , although few @entity1 had dietary intakes > 700mg/d. LIMITATIONS: Nutrient intakes derived from food-frequency questionnaires, lack of data on stone composition for all cases. CONCLUSIONS: Total and supplemental @entity620 intake was significantly associated with higher risk for incident @entity1290 in @entity1 , but not in @entity1 .
