Intestinal inflammation and tissue injury in response to heat stress and cooling treatment in XXXX .

@entity2304 @entity1944 @entity12427 @entity64 @entity12782 @entity66 @entity8929 @entity2047 @entity19 @entity635 @entity1618 @entity777 @entity58 @entity637
Gut-derived endotoxin and pathogenic bacteria have been proposed to be important causative factors of morbidity and mortality due to @entity64 . However, the molecular mechanisms underlying the small @entity1944 caused by @entity64 have yet to be well characterized. In order to verify the possible inflammatory pathogenesis of intestinal tissue injury, a @entity19 @entity64 model was established. Cooling treatment was applied, mimicking the clinical therapy. Morphologic changes in intestinal tissue and 10 cytokines and chemokines produced from ileum tissue were detected, and their correlation was analyzed. As a result, @entity1944 in @entity19 worsened with the increase in rectal core temperature (Tc) during heat stress. When heat stress was halted at a Tc of no more than 41  C followed by cooling treatment, pathological recovery from the @entity66 was observed. However, when cooling treatment was applied after the Tc reached 42  C, the lesions continuously deteriorated until the animals succumbed. The levels of pro-inflammatory ( @entity635 , @entity2047 , @entity777 and @entity637 ) and anti-inflammatory ( @entity1618 , @entity12782 ) cytokines showed significant changes at different time points during the heat stress and cooling treatment, but no changes in @entity2304 , @entity8929 , @entity12427 and @entity58 were observed. Levels of @entity635 , @entity1618 and @entity12782 were moreover significantly correlated with @entity1944 scores. A significant inverse linear correlation was observed between @entity1944 and @entity12782 levels. In conclusion, this study provided insight into the inflammatory pathogenesis of intestinal tissue injury after heat stress and cooling treatment in a @entity19 model, and presented a potential biomarker for the evaluation of @entity1944 during @entity64 .
