Metastasis-Free Interval Is Closely Related to Tumor Characteristics and Has Prognostic Value in XXXX @entity1 with Distant Relapse.

@entity1 @entity0 @entity5 @entity86 @entity3
PURPOSE: We investigated the relationships between @entity3 -free interval (MFI) and @entity5 characteristics, and assessed the prognostic value of MFI for survival after @entity3 in @entity1 with metastatic @entity0 . Furthermore, we compared MFI among the subtypes. METHODS: We identified 335 @entity1 with @entity86 recurrence at distant site(s). All @entity1 underwent curative resection and had a MFI of at least 6 months. MFI was categorized as short (<2 years), intermediate (>= 2 years and <5 years), or long (>= 5 years). Overall survival after @entity3 (OSM) was estimated. RESULTS: @entity1 with a shorter MFI were younger, more likely to have initial @entity3 to visceral organs, and had a larger @entity5 with a higher stage and grade as well as a higher rate of nodal involvement at initial diagnosis. Among 136 @entity1 with known disease subtypes, shorter MFI was associated with the triple-negative subtype while longer MFI was associated with the hormone receptor-positive/ @entity1 epidermal growth factor receptor 2 negative subtype. Mortality after @entity3 declined sharply with increasing MFI up to approximately 2 years, and continued gradually declining between 2 and 5 years. An MFI longer than 5 years did not add any survival benefit. MFI was a significant prognostic factor for OSM independent of nodal status, stage, metastatic site, and hormone receptor status of the metastasized @entity5 . CONCLUSION: MFI is closely related to biological characteristics of both @entity5 and their metastases, and has a prognostic value for survival after @entity3 . We therefore suggest investigation into treatments targeting improvement of MFI as a potential novel strategy.
