Transdifferentiation of Clara cell 10-kDa protein secreting cells in experimental XXXX .

@entity2023 @entity19 @entity1711 @entity28840 @entity619 @entity1710 @entity32123
BACKGROUND: The reasons for the down-regulated Clara cell 10-kDa protein ( @entity32123 ) expression in @entity2023 ( @entity2023 ) are unclear and the airway remodeling in @entity2023 has received little attention. This study explores epithelium remodeling and the change of @entity32123 secreting cells in @entity2023 by using a @entity19 model. METHODS: @entity2023 @entity19 models were established by ovalbumin sensitization and challenge. In some @entity19 , @entity619 was given before each challenge. Histological changes of nasal mucosa were examined by means of @entity1710 and @entity1711 and periodic acid-Schiff staining. @entity32123 and @entity28840 expression were evaluated by immunohistochemistry. RESULTS: In @entity2023 @entity19 , both in turbinate and in septal mucosa, total cell number and the number of basal cells did not change; however, the number of dome-shaped cells decreased and the number of ciliated and goblet cells increased in turbinate mucosa, and the number of ciliated cells decreased and the number of goblet cells increased in septal mucosa. In turbinate mucosa, the number of @entity32123 (+) cells (mainly dome-shaped cells) decreased whereas the number of @entity28840 (+) cells (mainly ciliated cells) increased. In septal mucosa, the number of @entity32123 (+) and @entity28840 (+) cells (mainly ciliated cells) decreased simultaneously. Intermediate phenotypic goblet cells could express @entity32123 and @entity28840 . @entity32123 and @entity28840 could be localized in the same cells. @entity619 reversed the changes of epithelium significantly. CONCLUSION: Allergen exposure leads to a possible transdifferentiation of @entity32123 secreting cells into @entity28840 secreting cells and/or goblet cells in upper airways. Nasal turbinate and septal epithelium display different patterns of transdifferentiation.
