Early markers of XXXX after liver transplantation: association with primary dysfunction.

@entity1 @entity14305 @entity3851 @entity5721
BACKGROUND: In @entity1 with @entity3851 , liver transplantation is the only available curative treatment. Although the outcome and quality of life in the @entity1 have improved over the past decades, primary dys- or nonfunction ( @entity14305 /PNF) can occur. Early detection of @entity14305 is crucial and could lead to individual therapies. This study was designed to identify early markers of @entity5721 and @entity14305 in liver biopsies taken during the first hour after reperfusion. METHODS: Biopsies from donor livers were prospectively taken as a routine during the first hour after reperfusion. Recipient data, transaminases and outcome were routinely monitored. In total, 10 biopsy specimens taken from @entity1 with 90-day mortality and @entity14305 , and @entity1 with long-term survival but without @entity14305 were used for DNA microarrays. Markers that were significantly up- or down-regulated in the microarray were verified using quantitative real-time PCR. RESULTS: Age, indications and labMELD score were similar in both groups. Peak-transaminases during the first week after transplantation were significantly different in the two groups. In total, 20 differentially regulated markers that correlated to @entity14305 were identified using microarray analysis and verified with quantitative real-time PCR. CONCLUSIONS: The markers identified in this study could predict @entity14305 at a very early time point and might point to interventions that ameliorate @entity5721 and thus prevent @entity14305 . Identification of @entity1 and organs at risk might lead to individualized therapies and could ultimately improve outcome.
