A @entity1 early response gene homologous to @entity19 XXXX and @entity35 @entity27803 , and related to the nuclear receptor superfamily.

@entity1 @entity1522 @entity19 @entity27803 @entity35635 @entity134 @entity35 @entity857 @entity5282 @entity39769
When a @entity1 fetal muscle cDNA library was screened with the @entity1 thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA. The sequence of the insert was 2498 basepairs, with an open reading frame of 1794 basepairs encoding a protein of 598 @entity1522 and a predicted molecular mass of 64 kDa. The DNA-binding domain and the ligand-binding domain are similar to those of @entity134 and thyroid hormone receptors. Moreover, this cDNA is highly homologous to @entity19 @entity39769 and @entity35 @entity27803 , which are early response genes induced by nerve growth factor and other serum growth factors. We designated this gene @entity5282 . The modulation of expression of @entity5282 during stimulation of cell growth was studied. The mRNA of @entity5282 was induced rapidly and transiently by growth-stimulating agents, such as @entity857 , in monkey kidney cells ( @entity35635 ), by phytohemagglutinin in @entity1 lymphocytes, and by serum stimulation of arrested fibroblasts. It is expressed in @entity1 fetal muscle and adult liver, brain, and thyroid. @entity5282 could be a nuclear receptor. It will be of great interest to determine the ligand for @entity5282 and the genes that are regulated by it.
