Effects of supplementation with fish oil-derived n-3 @entity1718 and @entity18943 on circulating plasma lipids and @entity844 profiles in XXXX .

@entity1 @entity7784 @entity8393 @entity9984 @entity844 @entity4600 @entity1674 @entity8534 @entity4601 @entity18943 @entity9539 @entity583 @entity1718 @entity165
BACKGROUND: @entity7784 ( @entity8393 ), @entity4600 ( @entity4601 ), and @entity18943 ( @entity9984 ) have lipid-modifying and antiinflammatory properties. The effects of supplement mixtures of these @entity1718 on plasma lipids and the @entity844 compositions of serum phospholipids have received little attention. OBJECTIVE: The objective was to determine the effects of different levels of @entity9984 supplementation together with a constant intake of @entity8393 plus @entity4601 on the @entity1674 -lowering effect of @entity8393 plus @entity4601 alone and on the @entity844 patterns (eicosanoid precursors) of serum phospholipids. DESIGN: Thirty-one @entity1 were assigned to 1 of 4 groups, equalized on the basis of their fasting @entity1674 concentrations. They received supplements providing 4 g @entity8393 + @entity4601 (4:0, @entity8393 + @entity4601 : @entity9984 ; control group), 4 g @entity8393 + @entity4601 plus 1 g @entity9984 (4:1), 2 g @entity9984 (4:2), or 4 g @entity9984 (4:4) daily for 28 d. Plasma lipids and @entity1718 of serum phospholipids were measured on days 0 and 28. RESULTS: Plasma @entity1674 concentrations were significantly lower on day 28 than on day 0 in the 4:0, 4:1, and 4:2 groups. LDL @entity165 decreased significantly (by 11.3%) in the 4:2 group. @entity8534 increased significantly in serum phospholipids only in the 4:2 and 4:4 groups; however, total @entity9539 increased in all 4 groups. CONCLUSIONS: A mixture of 4 g @entity8393 + @entity4601 and 2 g @entity9984 favorably altered blood lipid and @entity844 profiles in healthy @entity1 . On the basis of calculated PROCAM values, the 4:2 group was estimated to have a 43% reduction in the 10-y risk of @entity583 .
