Symptom clusters in XXXX .

@entity1 @entity135 @entity308 @entity322 @entity353 @entity390 @entity5 @entity73 @entity391 @entity3085 @entity148 @entity911 @entity2146 @entity22
CONTEXT: @entity1 with @entity5 often experience multiple concurrent symptoms. Few studies have explored symptom clusters (SCs) in this population. OBJECTIVES: The aim of the present study was to explore SCs in @entity5 , evaluate the characteristics associated with various clusters, and determine their relationship to survival. METHODS: This study included @entity1 in the palliative care program of the Hospital Universitario La Paz from 2003 to 2005. The Edmonton Symptom Assessment System and a supplement including 13 other symptoms were used to detect symptoms. Principal component analysis was performed to determine symptom relationships and compare SCs with associated parameters. RESULTS: In total, 406 @entity1 were included, 61% @entity1 and 39% @entity1 . The median age was 66.4 (range 18-95). The most common primaries were gastrointestinal (35%), lung (25%), genitourinary (8%), breast (5%), and @entity135 . The following clusters were identified: @entity911 ( @entity73 , @entity2146 , @entity322 ), neuropsychological ( @entity148 , @entity308 , and @entity22 ), @entity3085 ( @entity3085 , @entity353 , and tiredness), and gastrointestinal ( @entity390 and @entity391 ). The presence of these SCs was influenced by primary @entity5 site, gender, age, and performance status. Survival was related to the number of SCs present in a given @entity1 : zero SC, 52 days; one SC, 38 days; two SCs, 23 days; and three to four SCs, 19 days; P < 0.001. CONCLUSION: Different SCs can be identified in @entity1 with @entity5 . These SCs are influenced by primary @entity5 site, gender, age, and Eastern Cooperative Oncology Group performance status, and they can have prognostic value.
