Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in XXXX .

@entity1 @entity66 @entity303 @entity2045 @entity75 @entity1579 @entity3605 @entity51
OBJECTIVE: @entity3605 ( @entity3605 ) is a rapidly progressive @entity1579 with typical clinical findings of @entity303 , @entity66 , and @entity2045 and characteristic electroencephalographic (EEG) findings of bilateral synchronous periodic sharp waves. Advances in neuroimaging capabilities with diffusion-weighted and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) techniques have shown promise in the non-invasive diagnosis of @entity3605 . This series illustrates the correlation between the lateralized and focal clinical, EEG, and MRI FLAIR sequence abnormalities in 8 @entity1 (7 @entity1 and one @entity1 55-73 years old) with @entity3605 . METHODS: A case series of 8 @entity1 , evaluated at Mayo Clinic, who had a history of rapidly progressive lateralized or focal @entity51 and laboratory findings consistent with @entity3605 between 1996 and 1999 were identified. EEG, MRI of the head with FLAIR sequence, and cerebrospinal fluid studies were performed in all @entity1 . RESULTS: Mean time to death from symptom onset was 4 months. Symptoms were lateralized to the left hemisphere in 5 @entity1 and to the right hemisphere in two. One @entity1 showed bilateral occipital lobe involvement. In all @entity1 , the EEG showed lateralized or focal periodic sharp waves that colocalized with clinical @entity75 . FLAIR MRI images revealed increased signal in the cortical ribbon and deep gray matter corresponding to the lateralized clinical and EEG findings in 7 @entity1 . The other @entity1 had bilateral occipital increased signal on FLAIR MRI. CONCLUSIONS: @entity3605 may present with lateralized or focal cortical syndromes with colocalizing EEG and MRI findings. With the appropriate clinical history and laboratory evaluation, the corresponding areas of increased signal on FLAIR MRI provide supportive evidence of the disease. SIGNIFICANCE: @entity3605 can sometimes present with more focal or lateralized clinical findings, and the colocalizing EEG and MRI findings can help make or confirm the diagnosis of @entity3605 .
