Hepatic resection for XXXX in the elderly: a systematic review and meta-analysis.

@entity1 @entity55 @entity5 @entity96 @entity409 @entity177 @entity281
BACKGROUND: The number of elderly @entity1 undergoing hepatic resection for surgical treatment of benign and malignant @entity5 is increasing. However, there is limited clinical data on the complications and long-term survival rates associated with liver surgery in the elderly @entity1 (>= 70 years) versus younger @entity1 for @entity409 . METHODS: Six electronic databases were searched for original published studies comparing elderly (>= 70) versus younger (<70) cohorts for @entity96 . Data were extracted and analysed according to predefined clinical endpoints. RESULTS: Twenty-seven comparative studies were identified, including 4769 elderly @entity1 versus 15   855 younger @entity1 (n = 20   624). There was significantly higher 30-day mortality in the elderly colorectal liver metastasis group (P < 0.00002) and significant difference between elderly and young in terms of overall survival (hazard ration (HR), 1.10; P = 0.02). However, there was no difference in disease-free survival (HR, 1.05; P = 0.27). @entity55 , @entity177 and @entity281 were more frequent in the elderly group. CONCLUSIONS: Liver resection for @entity5 in the elderly is associated with a greater 30-day mortality and overall mortality when compared with younger cohorts, but similar disease-free survival. Length of stay and transfusions were not significantly different @entity55 , @entity177 and @entity281 were more frequent in the elderly group.
