Successful induction of ovulation and conception with combined gonadotropin-releasing hormone agonist plus highly purified follicle-stimulating hormone in @entity1 with XXXX .

@entity1 @entity4397 @entity53 @entity2670
Five @entity1 (group A) with @entity2670 ( @entity2670 ) and sterility for at least 3 yr were treated for 1 cycle for ovulation induction with a combined regimen of GnRH agonist ( @entity4397 ) plus highly purified FSH. The @entity1 received @entity4397 (Buserelin; 200 micrograms, sc, twice a day) for 6 weeks and then @entity4397 combined with FSH highly purified (2 ampules a day; 75 IU FSH and less than 0.11 IU LH in each ampule). Ovarian response was evaluated by plasma @entity53 (E2) assay and ultrasound examination, performed daily. Furthermore, plasma FSH and LH levels were assayed 3 times a week. Once a follicle was considered sufficiently developed, the combined regimen was withheld, and 24-48 h later hCG (5000 IU, im) was given. The results are compared with those of 31 ovulatory cycles induced by im FSH highly purified (group B) in @entity2670 @entity1 with the same FSH administration, clinical, and monitoring protocols. Ovulation was achieved in all cycles treated by @entity4397 plus FSH. Two singleton and a twin pregnancy resulted. Multiple follicular development occurred in all cycles. Plasma E2 levels were generally in the normal range. Echographic and endocrine features in the 2 groups were as follows. 1) basal ovarian @entity2670 were similar. 2) Group A had a greater number of follicles than did group B (P less than 0.01), while E2 to number of follicles and E2 to ovarian volume ratios were greater (P less than 0.01) in group B. 3) The linear correlations between plasma E2 levels and ovarian volume were markedly different in groups A and B (P less than 0.01). The regression line for group B had a steeper slope than that for group A. This finding indicates that at a fixed ovarian volume plasma E2 levels were significantly lower in group A than in group B. We conclude that the combined @entity4397 and FSH regimen may constitute an alternative and promising tool for the induction of ovulation in @entity1 with @entity2670 .
