A cross-sectional study of 'yaws' in districts of ghana which have previously undertaken @entity4580 mass drug administration for XXXX control.

@entity1 @entity36381 @entity11738 @entity1066 @entity4580 @entity272 @entity14329 @entity1865
Yaws, caused by @entity14329 ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of @entity4580 is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of @entity4580 at a lower target dose was previously undertaken in two regions of Ghana for the control of @entity11738 . Ongoing reporting of yaws raises the possibility that resistance may have emerged in @entity14329 pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for @entity11738 had previously been conducted. @entity1 aged 5-17 years with @entity1066 compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all @entity1 . 90 @entity1 with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for @entity14329 ssp pertenue was negative in all @entity1 , but @entity36381 DNA was detected in 9 lesions. In these communities, previously treated for @entity11738 , we found no evidence of ongoing transmission of yaws. @entity36381 was associated with a proportion of @entity272 , but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post- @entity1865 surveillance systems is required to better inform yaws control programmes.
