Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and Neuron Remodeling in Target Atrial Tissues in a XXXX Model.

@entity235 @entity22104 @entity528 @entity955
BACKGROUND: The long-term effects of ganglionated plexi ablation on electrophysiological characteristics and neuron remodeling in target atrial tissues remain unclear. METHODS AND RESULTS: @entity235 in group 1 (control, n=8) were not subjected to ganglionated plexi ablation and observed for 1 month, and @entity235 in groups 2 to 4 (ablation groups, n=8 each) underwent ablation of the right-sided ganglionated plexi and observed for 1, 6, and 12 months, respectively. Atrial electrophysiological characteristics were examined before ablation, immediately and continuously after ablation. Target atrial tissues were subjected to immunohistochemical staining and Western blot analysis. Atrial effective refractory period was significantly prolonged immediately after ablation (P<0.001), and persisted for 1 month (P<0.05). Nerve densities decreased 1 month after ablation (P<0.001). These parameters reverted to preablation levels after 6 and 12 months. In the ablation groups, @entity955 was induced in 5 of 8 @entity235 after 1 month and in all animals after 6 and 12 months. @entity955 was not observed in the control group and in the experimental groups immediately after ablation. Moreover, the expression of the @entity22104 was upregulated after ablation. CONCLUSIONS: Ganglionated plexi ablation effectively prolonged atrial effective refractory period for a short period, but the long-term effects on atrial effective refractory period and the suppression of @entity955 induction were not persistent. Targeted @entity528 may be an important mechanism underlying the observed electrophysiological changes.
