Effect of an angiotensin II receptor antagonist, @entity22666 , on XXXX @entity1373 after balloon injury.

@entity4688 @entity235 @entity2814 @entity1373 @entity1564 @entity22666 @entity1122
The roles of angiotensin (Ang) II as produced by two different enzymes, @entity2814 ( @entity2814 ) and chymase, were investigated in a @entity235 experimental model where @entity1373 was induced by balloon catheterization in the common carotid and femoral arteries. The animals received oral @entity22666 (3 mg/kg) or @entity4688 (10 mg/kg) twice a day for 5 weeks. After 1 week of active drug therapy, the common carotid and femoral arteries were unilaterally injured by balloon catheterization. In the common carotid arteries, both @entity2814 and chymase activities were increased by the injury, with the increase in chymase activities being greater than that in @entity2814 activities. In the femoral arteries, @entity2814 , but not chymase, activities were significantly increased by the injury. Both @entity22666 and @entity4688 reduced blood pressure almost equally. @entity4688 increased plasma @entity1122 activity more strongly than did @entity22666 , and significantly decreased vascular and plasma @entity2814 activities. @entity22666 significantly suppressed the formation of @entity1373 in both the carotid and femoral arteries, while @entity4688 significantly suppressed @entity1373 in the femoral, but not in the carotid arteries. These results indicate that local Ang II production by @entity2814 and chymase is involved in the @entity1373 seen in injured intima, and the difference in the inhibitory action of @entity1564 and @entity4688 reflects the extent of contribution of each enzyme. The effect of the @entity2814 inhibitor, @entity4688 , depended on the activity of @entity2814 , whereas that of the Ang II receptor antagonist, @entity1564 , was independent of @entity2814 activity.
