Comparison of trough effect of XXXX vs @entity4687 using self blood pressure measurement: EVERESTE study.

@entity1 @entity11559 @entity101 @entity9887 @entity4687
This multicentre study was aimed at comparing the trough effect of @entity9887 and @entity4687 on diastolic blood pressure ( @entity11559 ), using self blood pressure measurement (SBPM). A second objective was to compare the data obtained from SBPM with those provided by automatic office BP measurement. A total of 441 mild-to-moderate @entity101 @entity1 were randomised to receive either @entity9887 40 mg or @entity4687 4 mg for a period of 12 weeks. @entity1 whose clinic @entity11559 remained higher than or equal to 90 mmHg at the end of the 6th week (W6) were given a double-dose regimen. Office BP and SBPM were performed at baseline (W0), at W6 and at week 12 (W12), both with the same automatic device. A greater diminution of trough @entity11559 was obtained with @entity9887 (-6.6+/-6.7 mmHg) than with @entity4687 (-5.1+/-7.0 mmHg; P=0.018). Regarding clinic BP, the same results were observed. Doubling dose was significantly less frequent with @entity9887 (41%; n=85) than with @entity4687 (55%; n=115, P=0.005). Mean values of SBPM were lower than office BP values, with a difference of a greater importance at W0 than at W12: 6.6 vs 4.7 mmHg for systolic blood pressure (P<0.005) and 3.2 vs 1.4 mmHg for @entity11559 (P<0.0001). At W12, isolated office @entity101 was found in 9% of the @entity1 (n=37), while there were 14% of the @entity1 (n=55) with isolated home @entity101 . In conclusion, the trough effect on @entity11559 was statistically higher with @entity9887 than with @entity4687 . SBPM values were lower than office BP values, with greater differences before than after treatment. About a quarter of the @entity1 were found to be controlled with a method but not with the other one.
