Effect of XXXX on in vitro fertilization.

@entity1 @entity249 @entity66 @entity46 @entity4207
OBJECTIVE: To investigate the IVF outcome for @entity1 with @entity46 . DESIGN: Meta-analysis. SETTING: @entity4207 . @entity1 (S): A MEDLINE search and review of the literature were performed. @entity1 were classified by level of @entity46 , and controls were classified according to the indication for IVF. INTERVENTION(S): Bivariate analysis and multivariate logistic regression was used to estimate overall effect and control for confounding. MAIN OUTCOME MEASURE(S): Pregnancy rates, fertilization rate, implantation rates, and numbers of oocytes retrieved. RESULT(S): Twenty-two published studies were included in the overall analysis. The chance of achieving pregnancy was significantly lower for @entity46 @entity1 (odds ratio, 0.56; 95% confidence interval, 0.44-0.70) when compared with tubal factor controls. Multivariate analysis also demonstrated a decrease in fertilization and implantation rates, and a significant decrease in the number of oocytes retrieved for @entity46 @entity1 . Pregnancy rates for @entity1 with severe @entity46 were significantly lower than for @entity1 with @entity66 (odds ratio, 0.60; 95% confidence interval, 0.42-0.87). CONCLUSION(S): @entity1 with @entity46 -associated @entity249 undergoing IVF respond with significantly decreased levels of all markers of reproductive process, resulting in a pregnancy rate that is almost one half that of @entity1 with other indications for IVF. These data suggest that the effect of @entity46 is not exclusively on the receptivity of the endometrium but also on the development of the oocyte and embryo.
