[Autoimmune reaction component in chronic XXXX : clinical and experimental study].

@entity1 @entity788 @entity1689 @entity4306 @entity730 @entity792 @entity2723
The study was undertaken to identify the relationship between inflammatory and autoimmune processes in chronic @entity788 and to determine the prognostic significance of autoantibodies to antigens of acinar cells and hepatocytes, immunoglobulin G1-4. MATERIALS AND METHODS: In 85 @entity1 with @entity2723 (43 @entity1 , 42 @entity1 ) were studied autoantibodies to antigens of acinar and liver cells, IgG1-4. Of these, 43 @entity1 @entity4306 was characterized by complications (cysts, @entity730 , pseudotumoral form), 40 @entity1 -- @entity4306 without complications, 2 @entity1 were diagnosed @entity1689 ( @entity1689 ), confirmed histologically. 20 @entity1 -- the control group. Experimental studies on animals, reproduction of @entity1689 . RESULTS: Maximize the level of autoantibodies--32.4 +/- 5.6 U / ml (control--10.5 +/- 2.5 U / ml) (p < or = 0.01), as well as IgG4--24 mg/ml in normal (0.8 +/- 0.08 mg/ml)--was recorded in @entity1 with @entity788 . The average value of autoantibodies--in @entity1 with @entity2723 complications: 24.2 +/- 3.8 U/ml (p < or = 0.01). The minimum value of autoantibodies--in @entity1 with @entity2723 without complications: 18.6 +/- 2.6 U/ml (p < or = 0.05). CONCLUSION: The course of @entity788 accompanied by an increase of autoantibodies to antigens of acinar and liver cells, as well as serum IgG1-4, especially IgG4, which reflects the intensity of the autoimmune responses in this disease. In addition, the exacerbation of chronic @entity788 with complications is clearly defined @entity792 . Experimental studies with preimmunization of animals allogeneic tissues have convincingly demonstrated that the formation of antibodies is not only to the antigens, reflecting the specific characteristics of these tissues, but also to general cell structures of other tissues.
