A rapid XXXX bedside test for the identification of @entity32 in @entity3152 with intact membranes.

@entity1 @entity650 @entity32 @entity2907 @entity3152 @entity281 @entity6703 @entity790
OBJECTIVE: Preterm birth is associated with 5-18% of pregnancies and is the leading cause of neonatal morbidity and mortality. @entity6703 ( @entity6703 ) @entity650 ( @entity650 ) is a key cytokine for the identification of @entity32 , and @entity1 with an elevated @entity6703 @entity650 are at risk for impending @entity3152 . However, results of the conventional method of measurement (enzyme-linked immunosorbent assay; ELISA) are usually not available in time to inform care. The objective of this study was to determine whether a point of care (POC) test or lateral-flow-based immunoassay for measurement of @entity6703 @entity650 concentrations can identify @entity1 with @entity32 and/or @entity281 and those destined to deliver spontaneously before term among @entity1 with @entity3152 and intact membranes. METHODS: One-hundred thirty-six @entity1 with singleton pregnancies who presented with symptoms of @entity3152 and underwent amniocentesis were included in this study. Amniocentesis was performed at the time of diagnosis of @entity3152 . @entity6703 Gram stain and @entity6703 white blood cell counts were determined. Microbial invasion of the @entity2907 (MIAC) was defined according to the results of @entity6703 culture (aerobic and anaerobic as well as @entity790 ). @entity6703 @entity650 concentrations were determined by both lateral flow-based immunoassay and ELISA. The primary outcome was @entity32 , defined as @entity6703 ELISA @entity650   >=    2600   pg/ml. RESULTS: (1) @entity6703 @entity650 concentrations determined by a POC test have high sensitivity (93%), specificity (91%) and a positive likelihood ratio of 10 for the identification of @entity32 by using a threshold of 745   pg/ml; (2) the POC test and ELISA for @entity650 perform similarly in the identification of MIAC, acute inflammatory lesions of placenta and @entity1 at risk of impending spontaneous @entity3152 . CONCLUSION: A POC @entity6703 @entity650 test can identify @entity32 in @entity1 who present with @entity3152 and intact membranes and those who will subsequently deliver spontaneously before 34 weeks of gestation. Results can be available within 20   min - this has important clinical implications and opens avenues for early diagnosis as well as treatment of @entity32 / @entity281 .
