XXXX mutation in interdigitating @entity8790 : a case report and review of the literature.

@entity1 @entity5 @entity8790 @entity1259 @entity8554 @entity1583 @entity1260 @entity817 @entity320 @entity5457
UNASSIGNED: Interdigitating @entity8790 is an extremely rare @entity5 . The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes @entity320 , mesenchymal and @entity1583 . The mainstay of treatment is surgery for limited disease and different chemotherapy combinations have been tested for advanced disease. No evidence from prospective trials is currently available. We report the case of a 59  year-old male @entity1 who experienced axillary lymphadenopathy with initial diagnosis of large-cell lung cancer on tumor biopsy. He underwent surgical resection with radical intent. Pathological diagnosis of interdigitating dendritic cell sarcoma was obtained on surgical samples. Nine months after radical surgery, he experienced systemic recurrence of disease and underwent chemotherapy with @entity1259 and @entity1260 for 4 courses. During chemotherapy, he developed brain disease progression and underwent whole-brain radiotherapy. Systemic progression was then observed and molecular characterization was performed. @entity817 evaluation resulted positive for @entity8554 mutation and the @entity1 was treated with @entity5457 according to molecular findings. He thus obtained initial clinical benefit but eventually died of brain hemorrhage. In conclusion, we report a case of @entity817 mutation detected in an interdigitating dendritic cell sarcoma @entity1 treated with targeted therapy. @entity817 pathway could have a role in pathogenesis and evolution of this rare disease and could open new perspectives of treatment.
