Changes in the proliferative activities of cells in experimental XXXX plaques during remodeling.

@entity95 @entity12914 @entity3960 @entity1856 @entity731 @entity165
To investigate the relationship between cytologic alterations and cellular proliferation during @entity731 remodeling, we examined experimental @entity1856 by immunohistochemistry. Plaques were formed on @entity95 aortas by @entity165 -enriched diets and mechanical stimulation over a period of 2 months. Plaques were examined 1 month and 6 months after induction. We used antibodies RAM-11, HHF-35, and monoclonal anti-proliferating cell nuclear antigen ( @entity12914 ) antibody for detection of macrophages (Mphi), @entity3960 ( @entity3960 ), and @entity12914 , respectively. One month after induction, the plaques revealed a thickened intima with a fibrofatty histologic pattern or accumulation of foam cells. With either histologic pattern, foam cells were found to be Mphi and proliferative activity was mainly observed in Mphi. Six months after induction, calcification and organization were seen on the induced plaques, suggesting progression of remodeling. There were fewer Mphi and more @entity3960 compared with plaques examined 1 month after induction. Proliferative activity was observed mainly in @entity3960 . We have demonstrated that the proliferative activity of cell types changes during remodeling of @entity1856 . Our results suggest an important relationship between the proliferative activity of @entity3960 and remodeling.
