The XXXX complex: aortic valve, atherosclerosis, aortopathy.

@entity1 @entity4503 @entity449 @entity2334 @entity439 @entity453 @entity472
BACKGROUND: @entity472 may be related to @entity453 in @entity1 with tricuspid aortic valve, while aortic dilatation often is present in @entity1 with @entity4503 . We sought to define associations among @entity472 , @entity453 , and @entity2334 in @entity1 with tricuspid or @entity4503 undergoing surgery for @entity472 in a large referral medical center. METHODS: Two hundred seventy @entity1 with severe @entity472 (tricuspid 175, bicuspid 95) undergoing surgical aortic valve replacement (AVR) were studied. RESULTS: Coronary artery bypass grafting (CABG) surgery plus AVR was required more often in tricuspid compared to @entity4503 [62.2% versus 26.3%; p<0.0001; odds ratio 4.5, confidence interval (CI) 2.5-8.3]. The incidence of @entity453 requiring CABG in @entity4503 (26.3%) was greater than that expected in the general population for similar age. Thoracic aorta surgery due to @entity449 plus AVR was performed more often in bicuspid compared to tricuspid aortic valve (27.3% versus 3.4%; p<0.0001; odds ratio 7.7, CI 3.0-22.1). The incidence of ascending @entity439 requiring surgery, however, was not more common in tricuspid aortic valve (3.4%) to that expected in the general population for similar age. CONCLUSION: Incidence of @entity453 is high in @entity1 with @entity472 , both in those with tricuspid and @entity4503 . Incidence of ascending @entity449 is high in @entity1 with bicuspid, but not those with tricuspid aortic valve. These findings should be taken into consideration in the evaluation and management of @entity1 with the @entity472 complex.
