Effect of desmopressin on XXXX and @entity190 in @entity1 undergoing valvular heart surgery.

@entity1 @entity7062 @entity1423 @entity190 @entity2880
BACKGROUND: @entity190 after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or @entity7062 ( @entity7062 ) is a synthetic analog of vasopressin. @entity7062 can increase the level of @entity2880 factor VIII, thus it may enhance PLT function and improve coagulation. In this study, we assessed the effects of @entity7062 on @entity1423 and @entity190 in @entity1 undergoing cardiac surgery. METHODS: A total of 102 @entity1 undergoing valvular heart surgery (from October 2010 to June 2011) were divided into @entity7062 group (n = 52) and control group (n = 50). A dose of @entity7062 (0.3  g/kg) was administered to the @entity1 intravenously when they were being re-warmed. At the same time, an equal volume of saline was given to the @entity1 in the control group. @entity1423 rate was measured with the AggRAM four-way @entity1423 measurement instrument. The @entity190 and transfusion, hemoglobin levels, PLT counts, and urine outputs at different time were recorded and compared. RESULTS: The postoperative @entity190 in the first 6 h was significantly reduced in @entity7062 group (202    119 ml vs. 258    143 ml, P = 0.023). The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in @entity7062 group (3.8% vs. 12%, P = 0.015). There was no significant difference in the @entity1423 , urine volumes, red blood cell transfusions and @entity190 after 24 h between two groups. CONCLUSIONS: A single dose of @entity7062 can reduce the first 6 h @entity190 and FFP transfusion postoperatively in @entity1 undergoing valvular heart surgery, but has no effect on @entity1423 .
