[Relation between paraoxonase activity, other HDL components and inflammatory state in hemodialyzed XXXX ].

@entity1 @entity533 @entity72004 @entity1674 @entity740 @entity412 @entity1675 @entity1938 @entity165
Advanced @entity740 (CKD) is closely associated with a pro-inflammatory condition, with an increase in @entity412 -rich lipoproteins and decrease in HDL level. HDL contains antioxidant enzymes such as paraoxonase ( @entity533 ), whose activity is diminished in CKD. The aim of our study was to evaluate the relationship between @entity533 activity with HDL @entity165 , @entity1675 and hs-CRP levels, which are known to be inflammatory markers in hemodialyzed @entity1 . Forty-two @entity1 were studied; age, median (range) = 50 (25-67) years old, gender M/F = 22/20, duration of hemodialysis = 4.4    0.5 years, BMI: 23    0.5 kg/m2. After a 12 h fast, a blood sample was obtained and classic components of lipid profile were determined, as well as apoproteins @entity1938 , @entity533 by means of its arylsterase activity and hs-CRP levels. On the basis of the latter, @entity1 were divided into two groups: hs- @entity72004 (low risk, range: 0.1 to 1.0 mg/l) and > 1 mg/l (moderate and high risk, 1.1 to 10.7 mg/l). No difference was found in @entity1674 , LDL @entity165 and apo B in the groups. @entity1 with hs- @entity72004 showed lower HDL @entity165 (40    2 mg/dl) and @entity1675 (118    4 mg/dl) than @entity1 with hs- @entity72004 (50    4 and 133    5, respectively); p < 0.05. @entity533 was lower in hs- @entity72004 = 90.5    24.0   mol/ml.min than in hs- @entity72004 = 105.2    18.0. Consequently, inverse correlations were obtained between @entity1675 and hs-CRP, r = -0.381, p = 0.013 and between @entity533 and hs-CRP, r = -0.32, p = 0.042. Furthermore, increase in hs-CRP correlated positively with BMI r = 0.318, p = 0.042. Since @entity1675 has an anti-inflammatory role and @entity533 an antioxidant activity, the decrease in HDL and its components, @entity165 , @entity1675 and @entity533 , in subjects with higher chronic inflammatory condition might explain, in part, the increased cardiovascular risk in these @entity1 .
