XXXX -resistant @entity3964 @entity311 in Ilorin, Nigeria: prevalence and risk factors for treatment failure.

@entity1 @entity3147 @entity3964 @entity311 @entity503
Presumptive treatment of fever with @entity503 (CQ) remains the major strategy for @entity311 control in Nigeria. Efficacy surveillance of CQ must therefore be continuous for this strategy to remain valid. In this study we determined the efficacy of CQ in 120 @entity1 aged 6m to 34yr who presented with acute uncomplicated @entity3964 @entity311 . Clinical success was 86.6%. Parasitological cure was 56.7%. Mean fever and parasite clearance times were 2.5 +/- 1.2D and 4.2 +/- 1.6D, respectively. Recrudescence rate was 24.45%. Twenty-four @entity1 (20%) showed R11 response while 6 @entity1 (5%) showed R111 response. Risk of treatment failure was significantly higher among @entity1 (< or = 15 yr) [P = 0.02, RR = 2.35 ] and among @entity1 whose level of parasitaemia on day 2 was higher than day zero value. [P = 0.04; RR = 6.54]. Although @entity3147 was not associated with higher risk of parasitological failure (P = 0.52), the proportion of @entity1 with R11/R111 response compared to R1 response was significantly higher among malnourished @entity1 compared to @entity1 with satisfactory nutritional status (OR 2.92; p = 0.001). The findings suggests the need for extra vigilance of CQ-Resistant @entity3964 (CRPF) @entity311 in @entity1 in general, and malnourished @entity1 in particular if potentially serious complications are to be averted.
