Clinical importance of obesity versus the metabolic syndrome in XXXX in @entity1 : a report from the @entity1 's Ischemia Syndrome Evaluation (WISE) study.

@entity1 @entity64 @entity712 @entity583 @entity28 @entity6 @entity353 @entity741 @entity209 @entity453 @entity204 @entity65 @entity1851
BACKGROUND: Obesity and the @entity209 frequently coexist. Both are associated with @entity65 ( @entity65 ). However, the contribution of @entity28 to @entity65 , independent of the presence of the @entity209 , remains controversial. METHODS AND RESULTS: From the WISE study, 780 @entity1 referred for coronary angiography to evaluate suspected @entity741 were classified by body mass index (BMI; <24.9=normal, n=184; > or =25.0 to < or =29.9=overweight, n=269; > or =30.0= @entity28 , n=327) and presence (n=451) or absence (n=329) of the @entity209 , further classified by @entity6 status. Prevalence of significant angiographic @entity453 ( @entity453 ; > or =50% stenosis) and 3-year risk of @entity65 were compared by BMI and metabolic status. The @entity209 and BMI were strongly associated, but only @entity209 was associated with significant @entity453 . Similarly, unit increases in BMI (normal to overweight to @entity28 ) were not associated with 3-year risk of @entity204 (adjusted hazard ratio [HR] 0.92, 95% CI 0.59 to 1.51) or major adverse cardiovascular event (MACE: @entity204 , nonfatal @entity583 , @entity64 , @entity712 ; adjusted HR 0.95, 95% CI 0.71 to 1.27), whereas metabolic status (normal to @entity209 to @entity6 ) conferred an approximate 2-fold adjusted risk of @entity204 (HR 2.01, 95% CI 1.26 to 3.20) and MACE (HR 1.88, 95% CI 1.38 to 2.57). Levels of @entity1851 (hs-CRP) were more strongly associated with @entity209 than BMI but were not independently associated with 3-year risk of @entity204 or MACE. CONCLUSIONS: The @entity209 but not BMI predicts future @entity65 in @entity1 . Although it remains prudent to recommend @entity353 in overweight and @entity28 @entity1 , control of all modifiable risk factors in both normal and overweight @entity1 to prevent transition to the @entity209 should be considered the ultimate goal.
