High positive frequency of antibodies to metallothionein and @entity1457 protein 70 in sera of XXXX with @entity566 .

@entity1 @entity483 @entity2285 @entity1457 @entity566 @entity1097 @entity792
Two principal types of stress protein, @entity1457 proteins (hsps) and metallothionein (MT), are induced in cells responding to a variety of stresses. They play an important role in protecting cells from these stresses. However, many reports indicate that antibodies to hsps are present in human serum and are associated with several @entity792 . Metals, which are commonly allergenic to @entity1 , induce both MT and @entity2285 (one of the hsps family). Until now, there has been no report of any antibody to MT in human serum. In the present study, serum samples from healthy controls (Group I), and @entity1 suffering from @entity483 without (Group II) or with (Group III) @entity566 , were measured for antibodies to MT and @entity2285 , using an enzyme-linked immunosorbent assay (ELISA). @entity566 was confirmed by patch testing. We first found that antibody to MT exists in human serum. We also found a high positive frequency of antibody to MT (51.3%) and to @entity2285 (43.6%) in the sera of Group III, compared to those of Group I (3.8% and 5.1%) or Group II (6.4% and 5.1%). Furthermore, there was a strong positive correlation between antibody to MT and antibody to @entity2285 in Group III (P = 0.0013), but not in Group I and Group II. Our results indicate that antibody to MT exists in human serum, as do antibodies to hsps, and suggest that elevated levels of MT and @entity2285 antibodies are associated with @entity566 in @entity1097 @entity1 .
