[Can proton magnetic resonance spectroscopy be of any value as a prognostic factor in XXXX ?].

@entity1 @entity90 @entity1313 @entity5 @entity38574 @entity2946 @entity4740
Proton @entity90 ( @entity90 ) is a noninvasive chemical analysis of metabolites in brain tissue. Metabolite ratios are useful because age dependant normal values are known and differ significantly from the values obtained in various diseases of brain tissues. AIM: The aim of our study was to evaluate whether @entity90 correlates with magnetic resonance imaging (MRI), course of disease, pathology of resected @entity5 after preoperative chemotherapy and can be of prognostic value in @entity1 with @entity2946 ( @entity2946 ). MATERIALS AND METHODS: Eight @entity1 with histologically proven @entity2946 were studied. All @entity1 underwent @entity90 and MRI at diagnosis and after neoadjuvant chemotherapy consisting of VCR,VP, @entity4740 ,CBCA. Preoperative chemotherapy was followed by surgery, radiotherapy and maintenance chemotherapy. Assessment whether MRI correlates with @entity90 after preoperative chemotherapy was performed. Additionally @entity90 was correlated with the course of disease and pathology results. RESULTS: Out of 8 @entity1 5 had partial remission of their @entity5 on MRI. Two of them had favorable reaction on @entity90 defined as elevation of NAA and Cr decrease in Cho,Lac/ @entity38574 . Both are alive and disease free. In 2 @entity1 no changes, compared with @entity90 at diagnosis were found. Both died of the disease. One had an indistinct positive change and died. Stabilization on MRI was observed in 1 @entity1 , who also had a good reaction on @entity90 . He is alive, disease free. Two @entity1 had disease progression on MRI. Both had poor reaction on @entity90 , one died, one is alive with disease. It was noticed that good response on @entity90 correlated with chemotherapy induced @entity5 changes observed in pathology specimens from resected @entity5 . Small number of @entity1 does not allow to draw conclusions but our results signal that @entity90 might be of prognostic value in @entity1313 .
