XXXX in a chronically immunosuppressed renal transplant recipient: report of a case and review of the literature.

@entity1 @entity9058 @entity5 @entity5426 @entity16102 @entity204
@entity5426 are rare malignant @entity5 of endothelial origin that occur predominantly in the adult population. To date, only 12 cases have been described after renal transplantation. We review the literature and present an additional case of a 59-year-old @entity1 in whom lower-extremity lesions of cutaneous @entity5426 developed several years after transplantation. Of the 13 @entity1 , clinical details were available in only 12 cases. There were 10 male and 2 female @entity1 . The mean age at diagnosis was 47.6 years (age range, 28-71 years). Almost all @entity1 were on a combination immunosuppressive regimen, and the interval between transplantation and the development of the @entity5 was variable in the range of 8 months to 12 years. In five @entity1 , the @entity5 arose within or adjacent to an arteriovenous fistula site. Cutaneous involvement was observed in only four cases. The histologic spectrum consisted of both well-differentiated and poorly differentiated @entity5 . In one @entity1 , features of the @entity9058 were clinically present and the @entity5 morphologically displayed prominent erythrophagocytosis. In two of the cases, including the @entity1 described in the current report, polymerase chain reaction was performed on lesional tissue for @entity16102 and the result was negative for the presence of viral DNA. Despite the use of multimodal aggressive therapy in most @entity1 , @entity204 as a result of disease dissemination occurred over variable time periods (range, 1-15 months).
