Effects of XXXX on cardiac repolarization, PR interval, and heart rate in @entity1 with @entity1566 .

@entity1 @entity1688 @entity451 @entity974 @entity1566 @entity973 @entity1162 @entity67
STUDY OBJECTIVE: To determine the effects of @entity973 ( @entity974 ) on heart rate and PR, @entity1162 in @entity1 with longstanding @entity1566 ( @entity1566 ). DESIGN: Randomized, active-treatment-controlled, dose level-blinded study, with allocation concealed. SETTING: University-affiliated, tertiary care medical center. @entity1 : Sixty otherwise healthy male and female outpatients with traumatic @entity1566 of more than 1 year's duration. Intervention. Oral administration and dose titration to tolerance of an immediate-release formulation of @entity974 . MEASUREMENTS AND MAIN RESULTS: The PR interval, heart rate, QT interval, and QTc interval obtained from standard 12-lead electrocardiograms (ECGs) at baseline (before administration of @entity974 ) and after 1 month of treatment were compared. The QTc intervals were derived by using Bazett's formula (equation) incorporated into standard computerized analyses of 12-lead ECG printouts. The paired t test was performed to test for the significance of differences between means and variances. No statistically significant differences were noted in heart rate or between ECG time intervals measured at baseline and after 1 month of treatment with @entity974 among all @entity1 with @entity1566 or between subgroups stratified by injury level ( @entity1688 , @entity451 ) or sex. CONCLUSION: During the 1-month period that @entity974 was administered, the heart rate and PR, @entity1162 all remained unchanged and stayed well within normal range in comparison to literature-derived control values. @entity973 does not appear to influence the length of cardiac time intervals or heart rate and, hence, is unlikely to cause potentially life-threatening @entity67 when administered long-term and taken orally in dosages of up to 30 mg/day. Specifically, cardiac repolarization (QTc interval) is unaffected in @entity1 with @entity1566 who continuously receive @entity974 for up to 1 month.
