Biomechanical and histological evaluation of muscle after controlled XXXX .

@entity32 @entity82 @entity548 @entity39 @entity4 @entity95 @entity158 @entity130
This study correlates force generation and healing in muscle after controlled @entity130 . Right tibialis anterior (TA) muscles from 30 @entity95 were strained to approximately 80% of failure while the left TA muscles served as control. Both injured and control muscles were then tested for ability to generate force. Seven animals were sacrificed immediately after testing and the muscles were examined grossly and histologically. Remaining animals were retested at 24 hours (N = 7), 48 hours (N = 8), and 7 days (N = 8). Contractile ability following injury was 70.5% of control immediately, 51.1% at 24 hours, 74.5% at 48 hours, and 92.5% at 7 days. Immediate histology showed limited distal fiber rupture and @entity548 . By 24 hours, histology showed fiber @entity39 , infiltration of inflammatory cells, @entity4 , and @entity548 . At 48 hours there was complete fiber breakdown and intense inflammatory cell proliferation. At 7 days @entity32 was reduced and collagen @entity82 more advanced. Our findings demonstrate that injured muscle begins functional recovery by 48 hours despite @entity32 and active healing. This suggests that decreasing muscle function seen clinically between 24 and 48 hours following @entity130 may result from @entity158 due to @entity32 . Scarring and @entity82 seen at 7 days may explain the frequent recurrence of injury to strained muscles.
