Distinctive clinical characteristics of malignant mesothelioma in young XXXX .

@entity1 @entity456 @entity298 @entity2615
Although considered a disease of the elderly, a subset of @entity1 with @entity2615 are young (<40 years). The goal of this study was to understand their characteristics and outcomes. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract @entity2615 cases (1990-2010). We modeled Kaplan-Meyer survival curves stratified by site of disease, and age of presentation. 2% (207 of 12345) of @entity2615 @entity1 are young. Sex distribution is comparable among the young (51% males, 49% females); males predominated (78%, 22%) in the older cohort. Frequency of @entity298 are similar in the young (47%, 48% respectively); @entity456 predominated in the old (90%, 9%). Cancer-directed surgeries are more frequent in the young. Regardless of histologic subtype, young @entity1 with pleural (11 vs. 8 months) and peritoneal (not reached vs. 10 months) @entity2615 had significantly improved overall survival. In multivariate analysis, younger age was an independent prognostic factor. Although rare, @entity2615 do occur in the young; their characteristics are distinct from those of older @entity1 . Further studies are needed to understand the interplay between genetic susceptibility and mineral fiber carcinogenesis in the pathogenesis of @entity2615 in the young.
