Effect of menopause hormone therapy on disease progression in XXXX : A systematic review.

@entity1 @entity1252
OBJECTIVE: To review the literature pertaining to the effect of postmenopausal hormone therapy on disease progression in @entity1 with @entity1252 . METHODS: We performed a systematic review using PubMed, Embase, and the Cochrane Central Register of Controlled Trials from January 1990 to December 2013 for observational studies and randomized clinical trials that study the effect of hormone therapy on the occurrence of flares in menopausal @entity1 with @entity1252 . The screenings of titles and abstracts, full text review, and risk of bias assessments were done by two independent reviewers. RESULTS: A total of 12,548 articles were identified. After title and abstract screening and removal of duplicates, 692 articles were retrieved for full text review. Five studies were deemed eligible for inclusion in the analysis, and the methodological quality was assessed. Two of the studies were randomized controlled trials and three were observational studies. One randomized controlled trial found that menopausal @entity1 who received hormone therapy were at a higher risk for developing minor to moderate flares of @entity1252 . In the other four studies, there was no significant difference in @entity1252 activity between hormone therapy and non-hormone therapy users. CONCLUSIONS: Hormone therapy in menopausal @entity1 with @entity1252 appears to be well tolerated. While there is some evidence supporting an increase in risk of mild to moderate flares among hormone therapy users, no association was identified between hormone therapy use and severe disease flares. In addition, hormone therapy was associated with significant improvement in menopausal symptoms and quality of life. Larger trials are required to assess the long-term effects of hormone therapy on the course of @entity1252 in menopausal @entity1 and to identify @entity1 characteristics associated with an increased risk of flares in the setting of hormone therapy exposure.
