Association of serum XXXX levels with gait speed and quadriceps strength in older adults.

@entity1 @entity1568 @entity6 @entity1009 @entity3157 @entity520
BACKGROUND: @entity520 is associated with skeletal muscle proteolysis, and alkali supplementation has shown improvements in lean body mass and urinary @entity1568 wasting in several studies. However, the association of @entity520 with functional outcomes has not been examined on a population-based level. STUDY DESIGN: Cross-sectional study. SETTING _ @entity1 : 2,675 nationally representative adults 50 years or older in the National Health and Nutrition Examination Survey 1999-2002. FACTOR: Serum @entity3157 level. OUTCOMES: Low gait speed and low peak torque were defined as being in the lowest sex-specific quartile of gait speed and peak torque, respectively. MEASUREMENTS: Serum @entity3157 was measured in all @entity1 . Gait speed was determined from a 20-foot timed walk. Peak torque was calculated using peak isokinetic knee extensor force. RESULTS: Serum @entity3157 level <23 mEq/L was present in 22.7% of the cohort. Compared with @entity1 with @entity3157 levels >= 23 mEq/L, those with @entity3157 levels <23 mEq/L had higher body mass index and serum albumin levels; were more likely to have low socioeconomic status, a diagnosis of @entity6 , or glomerular filtration rate <60 mL/ @entity1009 .73 m(2); and were less likely to use diuretics. Serum @entity3157 level <23 mEq/L compared with >= 23 mEq/L was associated with low gait speed (OR, 1.43; 95% CI, 1.04-1.95) and low peak torque (OR, 1.36; 95% CI, 1.07-1.74) after multivariable adjustment. The association with low peak torque was modified by race/ethnicity in @entity1 , but not @entity1 (ORs, 1.52 [95% CI, 1.08-2.13] for @entity1 , 2.33 [95% CI, 1.23-4.44] for nonwhite @entity1 , and 0.93 [95% CI, 0.47-1.82] for white @entity1 ). LIMITATIONS: Cross-sectional study using a single @entity3157 measurement. CONCLUSIONS: Lower serum @entity3157 levels are associated with slower gait speed and decreased quadriceps strength in older adults. Further studies should examine the effect of alkali therapy on functional outcomes.
