Decreased arterial elasticity in formerly early-onset preeclamptic XXXX .

@entity1 @entity455 @entity1255 @entity1674 @entity1468 @entity731 @entity65
OBJECTIVE: Preeclampsia is associated with cardiovascular @entity731 events later in life. Impaired arterial elasticity is considered to be a marker of @entity455 and to be involved in the @entity731 process. We investigated whether previously preeclamptic @entity1 have lower arterial elasticity indices in comparison with controls. DESIGN: Case-control study. SETTING: University Medical Center Groningen, the Netherlands. SAMPLE: 14 non-pregnant @entity1 with a history of early-onset @entity1468 (cases) and 16 non-pregnant @entity1 (controls) with an uncomplicated pregnancy in 2003-2004. METHODS: Measurement of radial artery elasticity indices combined with the brachial blood pressure using pulse wave contour analysis. The assessment of traditional risk factors for @entity65 ( @entity65 ) including body mass index, serum high-sensitivity C-reactive protein (hsCRP), serum insulin and plasma @entity1255 . MEAN OUTCOME MEASURES: Arterial elasticity indices and traditional risk factors for @entity65 in cases and controls. RESULTS: Arterial elasticity was impaired in cases as compared with controls. Body mass index, blood pressure, pulse pressure, hsCRP and @entity1674 were significantly higher in cases. CONCLUSION: Arterial elasticity indices are reduced in formerly preeclamptic @entity1 , indicating @entity455 . This and the more established risk factors for @entity65 are likely to contribute to a higher risk of @entity65 in @entity1 with a history of early-onset @entity1468 .
