@entity1792 for regional anticoagulation. Effects on blood @entity4095 , XXXX , and @entity3775 .

@entity1 @entity3775 @entity455 @entity548 @entity3265 @entity1792 @entity598 @entity460 @entity8608 @entity4095
Infusion of @entity1792 into the arterial line, followed by infusion of @entity460 into the venous line, has been used for regional anticoagulation during hemodialysis of @entity1 with @entity548 diatheses or heparin-induced antiplatelet antibodies. These @entity1 are often hospitalized in intensive care units where the use of a sorbent regeneration dialysis system is convenient. In this study, the use of regional @entity1792 anticoagulation during dialysis with a @entity8608 dialyzer on a REDY dialysis machine was investigated in eight @entity1 . The white blood cell count, arterial @entity4095 , arterial and venous @entity3265 , and arterial, venous and dialysate @entity3775 were measured. Similar studies were carried out on four other @entity1 undergoing dialysis with standard systemic heparin anticoagulation and cellulose @entity598 dialyzers. The white blood cell count was observed to decline moderately, reaching a nadir of 83.2% of control at 15 minutes. The @entity4095 was unchanged or increased. However, blood @entity3265 rose in four of five @entity1 , with the venous value always exceeding the arterial value. In two @entity1 , @entity3775 levels in blood increased as well, and in one @entity1 , a marked increase was observed in dialysate, and @entity455 , with the concentrations being highest in the dialysate. No such changes were observed in the patients anticoagulated with heparin. It was concluded that although @entity1792 is a useful agent for regional anticoagulation, it should not be used in sorbent regeneration systems.
