Medicinal clays improve the endurance of loaded inspiratory muscles in XXXX : a randomized clinical trial of nonpharmacological treatment.

@entity1 @entity650 @entity46139 @entity11028 @entity26 @entity1030
BACKGROUND: Inspiratory resistive breathing (IRB) challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an @entity650 ( @entity650 )-dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in @entity1030 ( @entity1030 ) is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET) and plasma @entity650 concentration following an IRB challenge. METHODS: This study was a randomized, parallel-group, unblinded clinical trial in a single-center setting. Forty-two @entity1 (aged 42-76 years) suffering from mild to severe @entity1030 participated in this study. Both groups completed 12 sessions of the @entity46139 ( @entity46139 ) (n=22) or leisure thermal activity (LTA) (n=19) in a thermal @entity11028 center in Italy. Pre- and postintervention spirometry, maximum inspiratory pressure, and plasma mediators were obtained and ET and endurance @entity26 expenditure (VO2Endur) were measured following IRB challenge at 40% of maximum inspiratory pressure. RESULTS: There was no difference in   @entity650 between the intervention groups. But, IRB challenge increased cytokine @entity650 plasma levels systematically. The effect size was small. A statistically significant treatment by IRB challenge effect existed in ET, which significantly increased in the @entity46139 group (P=0.003). In analysis of covariance treatment by IRB challenge analysis with LnVO2Endur as the dependent variable,   @entity650 after intervention predicted LnVO2Endur in the @entity46139 group, but not in the LTA group. Adverse events occurred in two individuals in the @entity46139 group, but they were mainly transient. One @entity1 in the LTA group dropped out. CONCLUSION: @entity46139 model improves ET upon a moderate IRB challenge, indicating the occurrence of a training effect. The LnVO2Endur/  @entity650 suggests a physiologic adaptive mechanism in respiratory muscles of @entity1030 @entity1 allocated to treatment. Both thermal interventions are safe.
