Weight-bearing asymmetry and vertical activity differences in a @entity35 model of post-traumatic XXXX .

@entity35 @entity626 @entity571 @entity158
OBJECTIVE: This study used a @entity35 model of post-traumatic @entity626 ( @entity571 ) created by anterior cruciate ligament transection with partial medial meniscectomy (ACLT  +  pMMx). In this model, mild to moderate structural changes that are typical of knee @entity571 have been observed within 2 and 8  weeks post-surgery. We aimed to determine whether @entity158 can distinguish between an ACLT  +  pMMx and a sham surgery group. DESIGN: Three-month old male @entity35 underwent ACLT  +  pMMx on their right hindlimb within two groups of n  =  6 each, and sham surgery within two groups of n  =  5 each. Assessments evaluated percent ipsilateral weight-bearing for static weight-bearing and 18 different variables of exploratory motor behaviour at multiple time points between 1 and 8  weeks post-surgery. Histology was performed on the right hindlimbs at 4 and 8  weeks post-surgery. RESULTS: Histology confirmed mild to moderate knee @entity571 changes in the ACLT  +  pMMx group and the absence of knee @entity571 changes in the sham group. Compared to the sham group, the ACLT  +  pMMx group had significantly lower percent ipsilateral weight-bearing from 1 through 8  weeks post-surgery. Compared to the sham group, the ACLT  +  pMMx group had significantly lower vertical activity (episode count, time, and count) values. CONCLUSIONS: These findings suggest that ipsilateral weight-bearing deficit and vertical activity limitations resulted from the presence of knee @entity571 -like changes in this model. When using the ACLT  +  pMMx-induced @entity35 model of knee @entity571 , percent ipsilateral weight-bearing and vertical activity distinguished between @entity35 with and without knee @entity571 changes. These variables may be useful outcome measures in preclinical research performed with this experimental post-traumatic knee @entity571 model.
