@entity3575 blood concentration-analgesic response relationship in the treatment of XXXX .

@entity1 @entity26 @entity3810 @entity6251 @entity282 @entity3575
The inter- and intrasubject variability in blood concentration-analgesic response relationship for @entity3575 were investigated using the technique of @entity1 -controlled analgesia (PCA) in 30 consenting @entity1 scheduled for surgical procedures involving an abdominal incision (15 upper and 15 lower abdominal incisions). All @entity1 had a thiopental, @entity3810 / @entity26 , pancuronium anesthetic with 200 microgram @entity3575 intraoperatively. @entity282 relief was provided with @entity3575 from a Janssen On-Demand Analgesic Computer (ODAC) set to provide a basal infusion rate of 20 microgram/hr, a bolus "demand" dose of 20 microgram, and a lockout period of 5 minutes. Frequent blood samples were collected immediately before @entity1 demanded doses, and these were taken as an estimate of the @entity6251 ( @entity6251 ). A mean of 22 samples (range 12 to 45) were collected per @entity1 over a mean study duration of 50 hours (range 24 to 72). The @entity1 required larger hourly @entity3575 doses in the first 6-hour period (83.9 +/- 30.1 microgram/hr) than in any other 6-hour period (mean values varied from 37.3 to 63 microgram/hr). The mean (+/- SD) hourly @entity3575 dose rate and total cumulative dose were 55.8 +/- 22 microgram/hr (range 28.8 to 136 microgram/hr) and 2739 +/- 1191 microgram (range 900 to 6260 microgram), respectively. The mean (+/- SD) @entity6251 was 0.63 +/- 0.25 ng/ml (five-fold range from 0.23 to 1.18) and the mean intrapatient coefficient of variation in @entity6251 was 30.2% (range 16 to 46%). The @entity6251 values remained relatively constant in all @entity1 over the 48-hour study period.(ABSTRACT TRUNCATED AT 250 WORDS)
