The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in @entity308 XXXX with insufficient response to treatment - a European multicentre study.

@entity1 @entity308 @entity7601 @entity72431 @entity33834 @entity72430 @entity1873 @entity42266 @entity72432 @entity41512 @entity4334
UNASSIGNED: So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5- @entity1873 and the 5- @entity7601 gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major @entity308 @entity1 , adequately treated with antidepressants for at least 4 weeks, were collected in the context of a European multicentre study on treatment-resistant @entity308 . We assessed suicidality using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for @entity308 (HAM-D). Treatment response was defined as HAM-D <=17 and remission as HAM-D <=7 after 4 weeks of adequate antidepressant treatment. The 5- @entity1873 @entity41512 ( @entity72430 ) single @entity4334 polymorphism (SNP) and the 5- @entity7601 @entity42266 , @entity33834 , @entity72431 and @entity72432 SNPs were selected for genotyping. Using logistic regression analyses, no association (P<0.05) could be found between any SNP and neither suicide risk nor personal history of suicide attempts. Interactions between 5HTR1A @entity41512 and 5HTR2A @entity33834 in suicide risk, and 5 @entity1873 @entity41512 and 5 @entity7601 @entity72431 in a personal history of suicide attempts have been reported (P=0.027 and 0.036, respectively); however, the results did not survive multiple testing correction. In conclusion, our study shows no association between 5HTR1A or 5 @entity7601 gene polymorphisms and both current suicide risk and personal history of suicide attempts. In addition, epistatic effects of 5HTR1A and 5 @entity7601 genes on suicidal behaviour were not significant, although sample size limitations do not allow definitive conclusions.
