Immunohistochemical Evaluation of XXXX Role in Skin Tags.

@entity1243 @entity28 @entity272
UNASSIGNED: @entity272 ( @entity272 ) are common benign dermal connective tissue neoplasms that are mainly composed of loose fibrous tissue. However, their exact etiology is not fully understood. @entity1243 is a major player in the biology and pathology of the skin and its appendages. It is linked to cell differentiation, proliferation, migration, and survival with pronounced effects on angiogenesis, blood flow, and tissue perfusion. This study aimed at investigating the possible role of @entity1243 in @entity272 pathogenesis and correlating its expression with different clinical and histopathological parameters. Using immunohistochemical techniques, we examined 90 subjects. These included 60 @entity28 cases with @entity272 and 30 age-, gender- and Body Mass Index-matched normal subjects as a control group. @entity1243 was overexpressed in @entity272 compared with normal skin (p   <   .001). Nuclear and nucleocytoplasmic patterns were significantly associated with cases both in epidermis (p   <   .04) and dermis (p   <   .001). Higher epidermal @entity1243 H score was significantly associated with female gender (p   =   .004) and haphazard collagen arrangement (p   <   .03). Higher dermal @entity1243 H score was significantly associated with smooth @entity272 (p   =   .01), dilated blood vessels (p   =   .04), presence of mast cells (MCs) (p   =   .002), presence of inflammatory cells (p   =   .004), and haphazard collagen arrangement (p   <   .001). In conclusion, @entity1243 may play a role in @entity272 pathogenesis through its effects on keratinocytes, fibroblasts and vascular endothelium. Further studies are recommended to clarify the molecular interplay between @entity1243 and MCs in ST pathogenesis. Further studies are also needed to determine the significance of its nuclear expression.
