The effects of @entity4082 on the hypothalamic-pituitary-gonadal axis in XXXX .

@entity1 @entity548 @entity1640 @entity4082 @entity1278
Serum luteinizing hormone (LH) responses to a course of @entity4082 were studied in eleven @entity1 with @entity1278 at different stages of the illness. In malnourished @entity1 basal levels of LH were invariably low. With the resumption of a normal weight a small but definite rise in LH levels was observed but this spontaneous response to weight gain was variable in that many @entity1 continued to exhibit abnormally low LH levels. The response to @entity4082 in terms of a rise in basal LH levels after administration of the drug, followed by a second peak of LH and subsequent @entity548 , was clearly dependent in part on the @entity1 's nutritional state. In the malnourished state the response to @entity4082 was usually either absent or incomplete. After the resumption of a more normal weight, the @entity1 invariably showed an initial rise in LH after the @entity4082 , but the second LH peak and subsequent menstruation were frequently not demonstrated. Six @entity1 maintained a normal body weight for at least six months after a course of @entity4082 , but only three of them resumed cyclical @entity548 . It was concluded that factors additional to the nutritional state contribute to the prolonged @entity1278 and that @entity4082 appears to have only a limited role in the treatment and management of @entity1 with the disorder. Some aspects of current knowledge of the endocrine mechanisms that regulate normal menstruation and of the mode of action of @entity4082 are outlined. The results of the present study are discussed against this background in an attempt to elucidate further the @entity1640 underlying the @entity1278 .
