Proliferation to apoptosis ratio as a prognostic marker in XXXX .

@entity10730 @entity1 @entity5 @entity1711 @entity1977 @entity189 @entity6578 @entity1710 @entity15709 @entity420
OBJECTIVES: To determine the @entity6578 ( @entity6578 ), Apoptotic Index (AI), the ratio of the two indices ( @entity6578 /AI) in normal endocervical glands, @entity15709 ( @entity15709 ) and invasive @entity420 , and to evaluate the relationship among these indices with various clinicopathological features. METHODS: The @entity6578 , AI and @entity6578 /AI ratio in cervical @entity420 were evaluated based on: (1) cell morphology in @entity1710 and @entity1711 -stained sections; (2) immunohistochemical study for Ki67 antigen and @entity10730 ( @entity10730 )-mediated @entity1977 nick end labeling (TUNEL). Eighty cases of invasive @entity420 and eighteen cases of @entity15709 ( @entity15709 ) adjacent to invasive @entity420 were included. Adjacent normal endocervical epithelium in 26 cases of @entity420 was included as control. RESULTS: The @entity6578 , AI and @entity6578 /AI in normal endocervical glands, @entity15709 and invasive @entity189 showed statistically significant differences (P<0.001). A significant positive correlation was found between AI and @entity6578 , as assessed by morphological features (P<0.001) and immunohistochemistry (P=0.006). The @entity6578 /AI ratio, determined by morphology, significantly correlated with staging (P=0.023) and survival (P=0.0045). Multivariate survival analysis showed that both @entity6578 /AI ratio determined by morphology (P<0.001) and stage of @entity5 (P=0.03) had independent prognostic value in invasive @entity420 . CONCLUSIONS: Tumor proliferation significantly correlated with apoptotic activity in cervical @entity420 . The @entity6578 /AI ratio was an independent prognostic factor associated with @entity1 survival. Histological determination of @entity6578 /AI ratio proved to be an economical and potentially useful adjunct in predicting clinical outcome of @entity1 with cervical @entity420 .
