Analysis of T2 signal intensity helps in the differentiation between high and low-grade @entity1313 in paediatric XXXX .

@entity5 @entity1 @entity1313
PURPOSE: Previous studies hypothesized that the analysis of magnetic resonance intensity of the solid portion in paediatric @entity5 can provide pre-surgical information about the histopathology. Classically, high signal-intensity in T2weighted (T2w) images identifies low-grade @entity5 , while anaplasia is characterized by T2 hypointensity. We aimed to investigate if T2w signal intensities can pre-operatively distinguish between low-grade and high-grade @entity1313 in paediatric @entity1 . METHODS: Two raters, blinded to the histological diagnosis, rated the signal intensity of MR images (T2w) from 36 @entity1 with newly diagnosed @entity1313 , 17 @entity1 with low-grade @entity1313 and 19 @entity1 with high-grade @entity1313 were included in this study. Relative T2 values were obtained by dividing the T2w values of the solid portion of the @entity5 by the T2w values of the vitreous humour. RESULTS: The best cut-off point to distinguish low and high-grade paediatric @entity1313 was 0.8. If the signal intensity was less than or equal to 0.8 the @entity5 was expected to be a high-grade @entity5 with a sensitivity of 100%. Prediction of a low-grade @entity5 was more uncertain with a sensitivity of 70.5%. Overall, 86% of the @entity5 would have been predicted correctly. CONCLUSION: Our data suggest that T2w signal intensities of the solid portion of @entity1313 in paediatrics can pre-operatively differentiate between low-grade and high-grade @entity5 . In addition, T2 hypointensity may be helpful in targeting stereotactic biopsy.
