[ @entity170 therapy and thyroid function. Influence of 6 months of XXXX treatment on thyroid function and bone density].

@entity1 @entity3163 @entity170 @entity2862 @entity1388
26 @entity1 were treated for @entity170 with 40 mg of @entity3163 twice a day (equivalent 36 mg of @entity2862 ) for a longer period. Mostly by reason of incompatibility, a reduction to half of the dose was necessary in six of these @entity1 . The control of plasma @entity1388 concentration indicated that only 10 @entity1 took their medicine regularly. Before treatment as well as three and six months after beginning of treatment the @entity1 were examined. In these examinations bone density was measured across the middle phalanx of the middle finger with a I-125-profile scanner. Size and function of the thyroid gland were evaluated by clinical aspects and with in vivo- and in vitro-methods for thyroid diagnostic. The program includes also a check up with a 12 canal-serum-autoanalyzer. In 10 @entity1 with warranted regular intake of the drug the increase of bone density was significant after three months already. In all 26 @entity1 a considerable increase of the alkaline phosphatase after three months was evident. Under the influence of @entity3163 no change was seen in function and size of thyroid gland. This result verifies the efficiency of @entity3163 in @entity170 -therapy without any measurable influence on thyroid function.
