Single lung transplantation for end stage XXXX .

@entity1 @entity3794 @entity2415 @entity454
BACKGROUND: The first successful single lung transplantation was carried out in 1983 for @entity3794 . Because of the inherent advantages of single lung transplantation, a transplantation programme has been started for @entity1 with @entity454 due to @entity2415 . METHODS: Between October 1990 and August 1993 25 @entity1 with severe @entity2415 (15 @entity1 , mean age 51 years) received a single lung transplant at our institution. All @entity1 were severely disabled with a mean (SD) 12 minute walking distance of 281 (165) metres. There were five deaths in the series, four in the first 20 days and one on day 503. Two @entity1 suffered graft compression by air trapping in the native lung. Bronchial narrowing requiring insertion of endobronchial stenting occurred in four @entity1 . RESULTS: Mean (SD) FEV1 improved from a preoperative value of 17.8(13%) predicted to a six month value of 53.6(13)%, and FEV1/FVC from 23.8(12)% to 68.6(15)%. After the transplant 12 @entity1 are in New York Heart Association (NYHA) class I and the rest of the survivors are in NYHA II. Actuarial survival was 82% at one year and 74% at three years. CONCLUSIONS: Single lung transplantation is an effective treatment for @entity454 due to @entity2415 and carries an acceptable mortality and morbidity.
