Adrenal autoantibodies and XXXX in @entity1723 .

@entity1 @entity1375 @entity3935 @entity5343 @entity1723 @entity792
Stored sera from 466 @entity1 with @entity1723 and from 144 controls were examined for organ-specific antibodies to @entity1 adrenal cortex. Adrenal antibodies were found in seven of the @entity1 with @entity1723 (1.5%) and in one control (0.7%). None of 91 black @entity1 with @entity1723 had adrenal antibodies. All of the seven @entity1 with adrenal antibodies had other organ-specific antibodies. Three had clinical @entity1375 and one was @entity3935 . All of these seven @entity1 had a HLA-B8-bearing haplotype, suggesting that the B8-bearing haplotype confers an extremely high "relative risk" for adrenal autoimmunity in @entity1723 . Organ-specific @entity792 and/or organ-specific antibodies were found in 30% of the first-degree relatives of these eight probands with the adrenal antibodies (seven with @entity1723 and one control). We conclude that screening @entity1 with @entity1723 for adrenal antibodies of low yield (1.9% among white @entity1 ). Further, adrenal antibodies may be present for at least two years without the development of @entity5343 . Antibodies reactive only to the zona glomerulosa of the adrenal cortex may be benign. @entity1 with @entity1723 and thyroid microsomal antibodies are more likely to have adrenal antibodies (6.5%), as are @entity1 with @entity1723 and a B8-bearing haplotype and those with @entity1723 and family histories of organ-specific autoimmunity.
