@entity1640 following cranial irradiation for XXXX .

@entity1 @entity2338 @entity7704 @entity1640 @entity189 @entity4614 @entity1218 @entity701 @entity30345 @entity2010
Eight @entity1 , one male and seven females, with no pre-existing @entity1640 , who developed symptoms of @entity4614 following cranial irradiation for @entity189 were studied 5 years or more after radiotherapy. All were @entity2338 . Four of the @entity1 with no GH response during insulin tolerance tests (ITT) showed increased GH in response to synthetic @entity1 @entity7704 (GRF-44). Four @entity1 had impaired @entity701 responses to ITT, and gradual but diminished @entity701 responses to ovine corticotrophin releasing factor ( @entity30345 ). There was no significant difference between mean peak increments in response to ITT and those in response to @entity30345 . TSH responses to @entity1218 were delayed in five and absent in two @entity1 ; four of these had low free T4 index. Prolactin was raised in all seven @entity1 and increased further in response to @entity1218 . Two @entity1 had impaired gonadotrophin responses to LHRH. None of the @entity1 had clinical or biochemical evidence of @entity2010 . These data suggest that post-irradiation @entity4614 in these @entity1 results from radiation damage to the hypothalamus leading to varying degrees of @entity1640 releasing or inhibitory factors.
