Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of XXXX .

@entity7333 @entity70704 @entity5764 @entity1435 @entity356
Aims. To optimize and verify the regulatory pathway of @entity70704 in the pathogenesis of @entity356 ( @entity356 ) by intelligent algorithm. Methods. Bioinformatics methods were used to analyze the features of structural domain in @entity70704 protein. Proteins with the same domains and similar functions to @entity70704 were screened out for reference. The possible regulatory pathway of @entity70704 was established by integrating the acting pathways of these proteins. Then, the similarity between the reference proteins and @entity70704 protein was figured out by multiparameter weighted summation method. The calculation result was taken as the prior probability of the initial node in Bayesian network. Besides, the probability of occurrence in different pathways was calculated by conditional probability formula, and the one with the maximum probability was regarded as the most possible pathway of @entity70704 . Finally, molecular biological experiments were conducted to prove it. Results. In Bayesian network of @entity70704 , probability of the acting pathway "S100A11 > @entity5764 > @entity1435 > MAPK > @entity7333 > Spindle protein > Centromere protein > Cell proliferation" was the biggest, and it was also validated by biological experiments. Conclusions. The possibly important role of @entity70704 in the occurrence of @entity356 was verified by theoretical analysis and preliminary test, helping in studying the relationship between @entity70704 and @entity356 .
