[Proceedings: Influence of @entity2340 on the XXXX effect of @entity1426 ].

@entity1792 @entity95 @entity1426 @entity2918 @entity2340 @entity551
When @entity1426 (AA) was given to a @entity95 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity2918 . Thus, it seems to depend on the biosynthesis of the @entity2918 . This @entity551 action is used as an indication of natural factors which modify the biosynthesis of @entity2918 in living subjects. @entity2340 was used on 8 male @entity95 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity1792 . With 5 others, after injection of AA, the isotonic liquid with @entity1792 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity1792 during @entity551 ). Several injections of AA were given until a constant @entity551 action resulted; then 4 mg/kg of @entity2340 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity551 effect in the @entity95 without heparin. 2) A previous treatment with 4 mg/kg of @entity2340 achieved a fall of 5-15%. 3) In heparinized @entity95 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity2340 obtained @entity551 of 45-50% in 5 @entity95 . It is concluded that in @entity95 @entity2340 is an activator of the biosynthesis of @entity2918 .
