Factors associated with the timing of diagnosis of XXXX : results from the MASTER registry.

@entity1 @entity49 @entity1151 @entity1150 @entity158 @entity1211
INTRODUCTION: @entity1211 ( @entity1211 ) are non-specific and thus can make diagnosis difficult, even for an experienced clinician. We aimed to evaluate the timing of diagnosis of @entity1150 ( @entity1150 ) and @entity1151 ( @entity1151 ) in Italian hospitals and to identify individual and clinical predictors of timely or delayed diagnosis. MATERIAL AND METHODS: MASTER is a multicenter prospective registry of @entity1 with acute @entity1150 and @entity1151 . Information on clinical presentation and diagnostic methods, temporary and permanent risk factors, were captured by an electronic data network at the time of the index event. RESULTS: Data on 2047 @entity1 (1024 males), 1505 with @entity1150 and 542 with @entity1151 , were analysed. Delayed diagnosis (i.e. more than 10 days from onset of symptoms) was observed in 340 (22.6%) @entity1 with @entity1150 and in 88 (16.2%) with @entity1151 , respectively. In @entity1150 @entity1 , factors associated with earlier diagnosis were the presence of multiple signs or symptoms (p=0.014), the presence of @entity158 (p=0.049), and previous @entity49 (p=0.016). Neither the presence of other known risk factors nor ongoing prophylaxis influenced the timing of diagnosis. In @entity1151 @entity1 , only multiple signs or symptoms at presentation (p=0.014) and the presence of transient risk factors (p=0.001) were significantly associated with earlier diagnosis. CONCLUSIONS: Substantial delays occur when diagnosing both @entity1150 and @entity1151 . The severity of presentation, but not @entity1 risk profile are associated with earlier diagnosis, even in @entity1 with signs or symptoms of @entity1151 .
