Total serum @entity165 , atherogenic indices and their longitudinal association with XXXX among US adults.

@entity1 @entity308 @entity165
Serum @entity165 , both total and lipoprotein fractions, has been associated with mid- and late-life @entity308 . Using longitudinal data on a large and ethnically diverse sample of urban adults, the associations of serum lipid profile measured by high or low total @entity165 (TC; >200   mg   dl(-1); <160   mg   dl(-1)) and by atherogenic indices, namely high total @entity165 and low-density lipoprotein @entity165 relative to high-density lipoprotein @entity165 , with change in total and domain-specific @entity308 over time were examined. Findings were compared by sex. (Hypothesis 1) In addition, baseline @entity308 as predictors for longitudinal change in lipid profile trajectory were tested. (Hypothesis 2) Mixed-effects regression analyses stratified by sex was used. Sample sizes of @entity1 (n) and repeated observations (n') were: Hypothesis 1 ( @entity1 : n=826 ; n'=1319; @entity1 : n=1099 ; n'=1817); Hypothesis 2 ( @entity1 : n=738; n'=1230; @entity1 : n=964; n'=1678). As hypothesized, a higher level of atherogenic indices was linked to faster increase in @entity308 symptom scores, particularly @entity308 affect and interpersonal problems, though this relationship was found only among @entity1 . Among @entity1 a U-shaped relationship between baseline TC and longitudinal increase in somatic complaints and a direct link between low TC and longitudinal putative improvement in positive affect was found. On excluding statin users among @entity1 , low TC was associated with slower increase in @entity308 affect over time, whereas high TC was associated with faster increase in interpersonal problems. In summary, atherogenic indices were directly linked to faster increase in @entity308 among @entity1 only. More studies are needed to explain these sex-specific associations.
