Genetic polymorphisms in XXXX , -P1, -T1, and @entity5321 and the risk of @entity1313 .

@entity1 @entity5513 @entity23747 @entity1313 @entity5 @entity11 @entity1653 @entity4192 @entity29875 @entity4191 @entity2596 @entity74 @entity9164 @entity5321
GST and @entity5321 genes are involved in metabolism of several compounds (e.g., solvents) that may play a role in @entity1313 etiology. We evaluated associations between polymorphisms in these genes and adult brain @entity5 incidence. Cases were 782 @entity1 with @entity1313 diagnosed from 1994 to 1998 at three United States hospitals. Controls were 799 @entity1 admitted to the same hospitals for nonmalignant conditions. DNA was extracted from blood samples that had been collected from 1277 subjects (80% of all subjects; 604 controls; 422 @entity11 , 172 @entity1653 , and 79 @entity5513 ), and genotyping was successfully conducted for @entity9164 null, @entity4192 null, @entity4191 @entity29875 , @entity4191 @entity23747 , @entity5321 RsaI, and @entity5321 Ins96. The @entity4191 105 @entity2596 / @entity2596 genotype was associated with increased @entity11 incidence [odds ratio (OR), 1.8; 95% confidence limits (CLs), 1.2, 2.7], with the estimated effect following a trend of increasing magnitude by number of variant alleles (Ile/Ile: OR, 1.0; Ile/ @entity2596 : OR, 1.3; @entity2596 / @entity2596 : OR, 2.1). The @entity5321 RsaI variant was weakly associated with @entity11 (OR, 1.4; 95% CL, 0.9, 2.4) and @entity5513 (OR, 2.3; 95% CL, 1.0, 5.3), with some indication of stronger associations among younger subjects. Estimated effects of the gene variants differed by @entity11 subtype. There was evidence of supermultiplicativity of the joint effect of @entity4191 @entity29875 and @entity5321 RsaI variants on both @entity11 and @entity5513 , even following adjustment of estimates toward a common prior distribution using hierarchical regression models. Previously reported associations between the @entity4192 null genotype and overall @entity11 incidence were not replicated, but an association with @entity1653 was observed (OR, 1.5; 95% CL, 1.0, 2.3). These findings may provide clues to both @entity74 .
