Renal Function and XXXX Gene Polymorphisms among Uygur and Kazak Populations in Xinjiang, China.

@entity71454 @entity15461 @entity71456 @entity71455 @entity71457
Background The association of genetic polymorphisms of @entity15461 gene with aging has not been thoroughly examined. Previous studies showed that longevity in the Uygurs was considerably greater than in Kazaks in Xinjiang. This study aimed to investigate the difference of renal function and @entity15461 gene polymorphisms between Kazak and Uygur normal populations in Xinjiang, China. Material and Methods A total of 249 Uygur and 386 Kazak clinically normal subjects were included in this study. Four single-nucleotide polymorphisms ( @entity71454 , @entity71455 , @entity71456 , and @entity71457 ) of the @entity15461 gene were genotyped using the ABI SNaPshot method. Estimated glomerular filtration rate (eGFR) was calculated according to the Chinese simplified MDRD equation. Results There were significant differences between Kazak and Uygur healthy populations in both allele frequencies and genotype distributions in @entity71456 and @entity71457 (P<0.05, respectively). When the subjects were divided into 2 groups according to the genotypes of the @entity15461 gene polymorphism, in the GA+AA genotype distributions of the @entity71454 , the differences I serum creatinine and estimated glomerular filtration rate between the Kazak and Uygur groups were statistically significant (P<0.05, respectively). In CC genotype of @entity71455 , serum creatinine was significantly higher in Kazaks compared with Uygurs (P<0.05). In GG genotype of @entity71456 , serum creatinine was significantly higher in the Kazak group compared with the Uygur group (P<0.05), as well as in CG+CC genotype of @entity71456 (P<0.05). Serum creatinine was significantly higher in the Kazak group compared with the Uygur group in TT genotype of @entity71457 (P<0.05), as was GT+GG genotype of @entity71457 . Haplotype analysis indicated that the frequencies of ACGT, GTGT, and GCCG haplotypes were significantly different between Kazak and Uygur healthy populations (P=0.04, P=0.018, P=0.000, respectively). Conclusions Significant differences in @entity15461 gene @entity71456 and @entity71457 polymorphisms were found between the Uygur and Kazak populations.
