Measurement of nasal @entity842 is useful for the diagnosis of XXXX -induced prolonged cough.

@entity1244 @entity33223 @entity1 @entity2023 @entity842
Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of @entity842 in nasal cavity air ( @entity33223 ) is influenced by @entity2023 and/or @entity1244 , both of which are common causes of UACS. We measured @entity33223 levels in @entity1 with UACS and those with other causes. We also examined the usefulness of measuring @entity33223 for differentiating @entity1 with @entity1244 from those without @entity1244 . The study included 93 adult @entity1 with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and @entity33223 was measured at the initial investigation. UACS was diagnosed in 58 @entity1 (62.4%), and @entity1244 was identified in 11 (19.0%) of the 58 @entity1 with UACS. Levels of @entity33223 in UACS did not differ from non-UACS etiologies (316.2  129.2 vs. 334.9  88.2 ppb; p=0.452), suggesting that the measurement of @entity33223 could not discriminate UACS from other etiologies of prolonged cough. However, @entity1 with @entity1244 showed significantly decreased @entity33223 levels (190.1  114.8ppb) compared with @entity1 with UACS without @entity1244 (345.7  114.6ppb; p<0.001) and non-UACS @entity1 (334.9  88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of @entity1244 in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a @entity33223 cutoff value of 279.0 ppb. These findings imply that the measurement of @entity33223 could be useful for diagnosis of prolonged cough associated with @entity1244 .
