Long term results and morbidity of paraaortic compared with paraaortic and iliac adjuvant radiation in clinical XXXX .

@entity1 @entity137 @entity5 @entity4797 @entity8682
BACKGROUND: Radiotherapy is accepted as standard adjuvant treatment for @entity5 and results in excellent survival rates. The optimal radiation field for @entity5 , however, is still being discussed. @entity1 AND METHODS: In a retrospective study we evaluated long-term results concerning survival, relapse-pattern, and acute and chronic @entity137 in @entity1 receiving adjuvant radiotherapy of the paraaortic and ipsilateral iliac lymph nodes (hockey-stick, @entity8682 ) versus radiotherapy of the paraaortic lymph nodes only (PA). From 1979-1997, 129 @entity1 (median age 32 years) in clinical stage I received adjuvant radiotherapy. Eighty-seven @entity1 were treated with 36 Gy to the @entity8682 field and 42 @entity1 were treated with a median of 28 Gy to the PA field. RESULTS: With a median follow-up of 7.7 years ( @entity8682 ) and 5.2 years (PA) the relapse rate was 3.4% and 2.4%, respectively. There was no abdominal or pelvic recurrence in either group. Radiotherapy was well tolerated in both groups. No significant difference in acute or chronic @entity137 was noted. However, lower gastrointestinal tract @entity137 and myelotoxicities appeared less frequent in the PA group. Second @entity5 only occurred in the @entity8682 group. Overall survival in the @entity8682 and PA group was 96.6% and 100%, respectively. No @entity1 died of @entity4797 . CONCLUSION: With paraaortic radiotherapy only, long-term disease-specific survival was excellent. Decreased risk of acute @entity137 and of second @entity5 are potential benefits of the reduced radiation field.
