Serum @entity461 and ionized XXXX levels as predictors of symptomatic hypocalcemia after parathyroidectomy.

@entity1 @entity459 @entity461 @entity460
OBJECTIVE: To evaluate whether perioperative @entity461 levels or ionized @entity460 levels are associated with symptomatic hypocalcaemia, in @entity1 undergoing parathyroidectomy for @entity459 . STUDY DESIGN: Prospective noncontrolled study of a cohort of 100 @entity1 , undergoing parathyroidectomy at a single tertiary care medical centre. METHODS: Prospectively collected data from January 2002 to April 2008 on 100 unique @entity1 undergoing parathyroidectomy for @entity459 were evaluated for age, sex, preoperative and intraoperative @entity461 levels, and preoperative and postoperative ionized @entity460 levels, extent of operation, final pathology, and postoperative symptomatic hypocalcaemia. Comparisons of those with and without symptomatic hypocalcaemia were made with Fisher's exact test for binary characteristics and with the Wilcoxon test for continuous characteristics. Results were deemed statistically significant at the 5% level (p < 0.05) with no correction for multiple comparisons. RESULTS: Twelve @entity1 (12%) developed symptomatic hypocalcaemia in the post operative period. Neither, initial levels nor subsequent changes in @entity461 or ionized @entity460 were found to be associated with symptomatic postoperative hypocalcaemia. @entity1 developing hypocalcaemia tended to be younger (p = 0.057) and showed a significantly higher percentage when multiple glands were removed (p = 0.026). CONCLUSION: Initial levels or subsequent changes in @entity461 or ionized @entity460 were not found to be associated with symptomatic hypocalcaemia. The removal of more than one gland did correlate with symptomatic post operative hypocalcaemia.
