Association of @entity31 with TNF-related apoptosis inducing ligand ( XXXX ) gene polymorphisms and plasma soluble @entity2205 levels in Chinese Han population.

@entity1 @entity71157 @entity2205 @entity33 @entity31 @entity29 @entity71692 @entity71693
OBJECTIVE: The precise etiology of @entity29 ( @entity29 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity33 -cell apoptosis in @entity31 ( @entity31 ) is unclear. In the present work we investigated the role of @entity2205 ( @entity2205 ), which is implicated in various @entity1 disorders. @entity1 AND METHODS: Results from a total of 393 @entity31 @entity1 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity2205 in 3' untranslated regions (UTR), and examined the plasma soluble @entity2205 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity2205 ( @entity71692 / @entity71693 / @entity71157 and @entity71692 and @entity71693 ) were much lower in @entity31 @entity1 compared to the controls. Furthermore, mutant allele and genotype of @entity2205 @entity71157 were more prevalent in severe @entity31 @entity1 than in other @entity1 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity31 @entity1 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity31 @entity1 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity2205 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity31 attack in Chinese @entity1 .
