@entity137 of Thymus vulgaris essential oil towards @entity1 XXXX .

@entity1 @entity137 @entity5 @entity1544 @entity6976 @entity213
BACKGROUND: Oral @entity1544 (OCSCC) accounts for 2% to 3% of all @entity5 and has a high mortality rate. The majority of anticancer drugs are of natural origin. However, it is unknown whether the medicinal plant Thymus vulgaris L. (thyme) is cytotoxic towards @entity213 ( @entity213 ). MATERIALS AND METHODS: @entity137 of thyme essential oil was investigated on the @entity213 cell line, UMSCC1. The IC       of thyme essential oil extract was 369  g/ml. Moreover, we performed pharmacogenomics analyses. RESULTS: Genes involved in the cell cycle, cell death and @entity5 were involved in the cytotoxic activity of thyme essential oil at the transcriptional level. The three most significantly regulated pathways by thyme essential oil were interferon signaling, N-glycan biosynthesis and @entity6976 ( @entity6976 ) signaling. CONCLUSION: Thyme essential oil inhibits @entity1 @entity213 cell growth. Based on pharmacogenomic approaches, novel insights into the molecular mode of anticancer activity of thyme are presented.
