Genome-wide transcriptome analyses reveal XXXX inactivation mediated loss of @entity7762 expression in malignant @entity1263 .

@entity1 @entity808 @entity1263 @entity8650 @entity5 @entity3292 @entity7762 @entity1264 @entity876 @entity3 @entity1265
@entity1263 ( @entity1263 ) are @entity8650 that occur either sporadically or in @entity1 with @entity1264 . The malignant transformation of the benign neurofibroma to @entity808 is incompletely understood at the molecular level. We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in @entity5 to @entity808 consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression. Relatively few genes are expressed at higher levels in @entity1263 and these include genes involved in cell proliferation and genes implicated in tumour @entity3 . In addition, a gene expression signature indicating @entity876 inactivation is seen in the majority of @entity1263 . Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of @entity7762 in most @entity1263 compared to @entity3292 . In vitro studies using the cell lines @entity808 -14 ( @entity1265 mutant) and @entity808 -724 (from a non- @entity1265 individual) show that exogenous expression of @entity876 or @entity7762 promotes apoptotic cell death. In addition, exogenous expression of @entity876 in @entity808 cells induces @entity7762 and other miRNAs. Our data show that @entity876 inactivation and subsequent loss of expression of @entity7762 may significantly contribute to the @entity808 development. Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in @entity1263 .
