@entity2355 expression as a predictor of the curative endoscopic treatment of submucosally invasive XXXX .

@entity3079 @entity2355 @entity189 @entity3 @entity14 @entity420
PURPOSE: This study was undertaken to clarify the clinical significance of @entity2355 expression in the endoscopic treatment of @entity14 with @entity3 . METHODS: One hundred eighty-four @entity14 with @entity3 were examined. The depth of @entity3 was classified as scanty or massive. The histologic subclassification at the deepest invasive portion was defined as well-differentiated, moderately well-differentiated, moderately to poorly differentiated, poorly differentiated, or @entity3079 . @entity2355 expression was examined immunohistochemically at the deepest invasive portion. In addition, the Ki67 labeling index was also examined immunohistochemically. RESULTS: Lymph node @entity3 were detected in 28 (15.2 percent) of 184 lesions. Lesions with both scanty @entity3 and well-differentiated or moderately well-differentiated @entity420 had no lymph node @entity3 . @entity2355 expression was detected in 88 (47.8 percent) of 184 lesions and correlated significantly with the presence of lymph node @entity3 . The Ki67 labeling index also correlated significantly with lymph node @entity3 . Furthermore, lesions with both @entity2355 -negative and low Ki67 labeling index showed no lymph node @entity3 , even in lesions with @entity3 . Multivariate analysis indicated that @entity2355 expression was one of the most important risk factors for lymph node @entity3 and histologic grade among the clinicopathologic factors usually examined. CONCLUSION: @entity2355 expression is one of the accurate predictors of the presence of lymph node @entity3 among the clinicopathologic factors commonly used. Combined analysis of @entity2355 expression and Ki67 labeling index may be a useful indicator of lymph node @entity3 and may broaden the indications for the curative endoscopic treatment of @entity189 with @entity3 .
