Baseline Characteristics and Disease Phenotype In XXXX Results of A Paediatric IBD Cohort.

@entity1 @entity31 @entity30 @entity29
BACKGROUND AND AIMS: Predicting short-term relapses and long-term prognosis is of outmost importance in paediatric @entity29 . Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. METHODS: From January 1, 2008 to December 31, 2010 demographic data and clinical characteristics of newly diagnosed paediatric @entity29 @entity1 younger than 18 years of age were prospectively recorded. RESULTS: A total of 420 @entity1 were identified [ @entity30 : 266; @entity31 124]. Initially, 48% (124/256) of @entity30 @entity1 had moderate to severe disease (PCDAI>31), and this rate decreased to 2.1% at one-year follow-up. Proportion of @entity31 @entity1 with moderate to severe disease (PUCAI>35) at diagnosis declined from 57.5% (69/120) to 6.8% at one-year follow-up. Terminal ileal involvement correlated with higher initial CRP (p=0.021) and initial PCDAI (p=0.026). In @entity31 , elevated CRP (p=0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at one year in @entity1 with @entity30 . Initial CRP was also associated with the need for immunomodulators in @entity1 with @entity31 at one-year follow-up. CONCLUSIONS: At diagnosis half of the @entity1 with @entity29 had moderate to severe disease and this rate decreased to less than 10% after one year. Initial CRP and PCDAI were related to the need for aggressive therapy in @entity30 .
