An Increased Risk of Second @entity5 After XXXX : Population-Based Evidence for a @entity5 ?

@entity1 @entity8357 @entity5 @entity2875 @entity980
BACKGROUND: @entity980 survivors have an increased risk of developing @entity5 ( @entity5 ); this risk is traditionally attributed to the effects of multidisciplinary management required for cure. However, the impact of constitutional predisposition has not been properly analyzed. METHODS: We analyzed the risk of @entity5 among 1,151 @entity1 diagnosed with @entity980 and reported to the Surveillance, Epidemiology, and End Results registries (SEER-9) from 1973 to 2010. Standardized incidence ratios (SIR) and corresponding 95% confidence intervals (CI) were calculated using SEERStat 8.1.2. RESULTS: @entity1 with @entity2875 had an increased risk of developing a @entity5 (SIR = 15.77, 95%CI 1.91-56.96 and SIR = 5.6, 95%CI 3.32-8.85, respectively). The risk was age-dependent; the highest was among @entity1 <2 years (SIR = 13.38, 95%CI 4.34-31.22) and the lowest was in @entity1 >10 years (SIR = 3.35, 95%CI 1.53-6.35). The risk for the youngest @entity1 was higher for those with @entity2875 (SIR = 14.72, 95%CI 4.01-37.70) compared to other histiotypes. Additionally, the risk of @entity5 was independent of the use of radiation to the primary (SIR = 6.50, 95%CI 3.97-10.03 and SIR = 4.57, 95%CI 2.09-8.68, for @entity1 receiving and not receiving radiation, respectively). The pattern of @entity5 observed was consistent with the @entity8357 -Fraumeni spectrum. CONCLUSIONS: @entity1 with @entity980 are at high risk of developing @entity5 . This risk is higher for a subgroup of young @entity1 with pleomorphic and embryonal histologies, and is independent of the use of radiation. This suggests that a subgroup of @entity1 with @entity2875 may have a constitutional @entity5 predisposition.
