Morphological effects of @entity4742 on neonatal XXXX uterus and vagina.

@entity1 @entity19 @entity4743 @entity3923 @entity4742 @entity5420
Administration of @entity4742 ( @entity4743 ) to neonatal @entity19 causes a high incidence of @entity3923 comparable to @entity3923 in @entity1 who were exposed to @entity4743 in utero. In the present study, scanning electron microscopy was used to investigate morphological events that might be involved in the development of @entity3923 . The effects of @entity4743 on luminal epithelia of neonatal @entity19 uterus, vaginal canal, and vaginal fornix were compared with the effects of the drug on those tissues of the adult @entity19 . BALB/c @entity19 were given five s.c. injections of 2 micrograms @entity4743 in @entity5420 oil or of @entity5420 oil alone (controls) on postnatal Days 1 through 5 and were killed on Day 7. Ovariectomized adult BALB/c @entity19 were given s.c. injections of 2 or 20 micrograms @entity4743 or of oil on 5 consecutive days and were killed 2 days after the last injections. In neonatal and adult uteri, @entity4743 stimulated the growth of microvilli on epithelial cells. The numbers of long and intermediate-length microvilli were markedly increased relative to those in control uteri. @entity4743 caused epithelial cornification in all samples of adult vaginal canal and fornix and in three of eleven Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4743 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4743 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4743 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, the response of neonatal fornicovaginal epithelium to @entity4743 resembled that of neonatal and adult uterine epithelium more than it resembled the response of adult fornicovaginal epithelium; the uterine-like response might be causally related to the development of @entity3923 .
