Increased @entity5 but uncompromised fertility in the female descendants of XXXX exposed developmentally to @entity4742 .

@entity1 @entity2175 @entity5 @entity19 @entity4743 @entity2659 @entity4742 @entity420
Prenatal exposure to @entity4742 ( @entity4743 ) has been associated with the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and @entity5 , in experimental animals and @entity1 . Experimental animal studies with chemical carcinogens have raised the possibility that adverse effects of @entity4743 may be transmitted to succeeding generations. To evaluate this possibility and to determine if there is a sensitive window of developmental exposure, outbred @entity2659 @entity19 were treated with @entity4743 during three stages of development: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body wt), the time of major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body wt) just prior to birth; group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). Female @entity19 (F1) in each group were raised to sexual @entity2175 and bred to control males. As previously reported, fertility of the F1 @entity4743 -exposed females was decreased in all groups. Female offspring ( @entity4743 lineage or F2) from these matings were raised to @entity2175 and housed with control males for 20 weeks. The fertility of these @entity4743 lineage female @entity19 was not affected by @entity4743 exposure of their 'grandmothers'. @entity4743 lineage @entity19 were killed at 17-19 and 22-24 months of age. An increased incidence of @entity5 , including uterine @entity420 , was seen in @entity4743 lineage @entity19 but not in corresponding controls; the range and prevalence of @entity5 increased with age. Because uterine @entity420 were seen in all three @entity4743 groups, all developmental exposure periods were considered susceptible to the adverse effects of @entity4743 . These data suggest that the reduced fertility observed in the @entity4743 F1 female @entity19 was not transmitted to their descendants; however, increased susceptibility to @entity5 formation is apparently transmitted to subsequent generations.
