Myocardial protection through cold cardioplegia with potassium or XXXX . Experimental evidence that @entity3988 provides better protection even when coronary flow is impaired by a critical @entity850 .

@entity64 @entity235 @entity4337 @entity3988 @entity850 @entity4338
Intermittent aortic root infusion of a cold solution containing either @entity4337 ( @entity4338 ) or @entity3988 was performed in 32 @entity235 during a 2-hour aortic clamping. Half of the @entity235 in each group had a critical @entity850 created on the circumflex artery before cardiopulmonary bypass. Global left ventricular (LV) function was determined 1 hour after bypass by means of LV pressure, peak dP/dt, LV end-diastolic pressure, cardiac and @entity64 work indexes. Regional function was assessed through microcrystals in the areas of the circumflex and left anterior descending coronary arteries. LV pressure decreased in all @entity235 , but more so with the @entity4338 solution (p = 0.02). The @entity850 had no specific effect on LV pressure, but affected peak positive dP/dt (p = 0.007) and LV end-diastolic pressure (p less than 0.0001). Cardiac and @entity64 work indexes decreased more in the @entity4338 group than in the @entity3988 group (p less than 0.002) with or without @entity850 . Both positive and negative dP/dt were affected by the type of solution (a greater decrease with @entity4338 ), but the narrowing affected only the positive dP/dt. Regional LV function remained unchanged in the absence of a narrowing and was depressed equally in @entity235 with a narrowing whether they received @entity4338 or @entity3988 . Overall LV function appeared to be better preserved with @entity3988 , with or without impairment of circumflex flow.
