Time trends in incidence, case fatality, and mortality of XXXX .

@entity1 @entity71240 @entity1779 @entity204 @entity19136
OBJECTIVE: To assess age- and sex-specific trends in incidence and 30-day and 1-year case fatality of @entity1779 ( @entity1779 ) in the Netherlands. METHODS: @entity1 hospitalized for first @entity1779 were identified through linkage of the national hospital discharge register and population register using ICD-9 code 431. We identified out-of-hospital deaths in the national cause of @entity204 register. Incidence, 30-day and 1-year case fatality, and total mortality rate were calculated by age and sex. We identified time trends by joinpoint regression analysis and Mann-Kendall tests. RESULTS: We identified 41,068 cases of @entity1779 (51% @entity1 ) between 1998 and 2010, of which 6% were out-of-hospital deaths. @entity1779 incidence declined in @entity1 and @entity1 younger than 75 years (p  <= 0.01, not significantly in @entity1 35-54 years) but remained stable in @entity1 75 years and older. Thirty-day and 1-year case fatality declined in @entity1 younger than 75 years (not significantly in @entity1 35-54 years). In @entity1 aged 35 to 54 years, @entity1779 mortality remained stable until 2003 and then declined slightly (annual percentage change [APC] @entity1 : -7.09%; 95% confidence interval [CI] -11.39 to -2.59; @entity1 : -8.67%; 95% CI -15.18 to -1.66). In @entity1 55 to 74 years, mortality declined in @entity1 between 1995 and 2010 ( @entity71240 .55%; 95% CI -5.49 to -3.59) and in @entity1 between 1992 and 2010 ( @entity19136 .51%; 95% CI -4.16 to -2.85). Mortality did not decline in @entity1 aged 75 years and older. CONCLUSION: In the Netherlands, @entity1779 incidence, case fatality, and mortality rates have declined significantly in @entity1 and @entity1 younger than 75 years but remained stable in @entity1 75 years and older. The observed time trends may be explained by better prevention and treatment during the previous 2 decades of which the elderly do not seem to benefit.
