Continuous intra-arterial infusion of @entity3931 during embolization of cerebral aneurysms associated with XXXX .

@entity1 @entity510 @entity3931 @entity439 @entity2473 @entity2553 @entity1756
BACKGROUND AND PURPOSE: Despite rigorous efforts, @entity2553 remains an important cause of morbidity and mortality in @entity1 who survive their initial @entity510 . In cases of @entity1756 associated with @entity2553 , we evaluated the effectiveness of combined embolization of an @entity439 and intra-arterial infusion of @entity3931 , which continued during the entire procedure. MATERIALS AND METHODS: Ten @entity1 with @entity1756 associated with @entity2553 who were treated in a single session were reviewed retrospectively. After initial intra-arterial infusion of @entity3931 (1-2 mg within 10-15 minutes), they underwent occlusion of the @entity439 with coils under continuous intra-arterial infusion of @entity3931 at a dose of 1 mg per hour. RESULTS: Angiography showed severe proximal @entity2553 in 1 @entity1 , proximal and distal in 3 @entity1 , and distal in 3 @entity1 . There was also moderate proximal @entity2553 in 4 @entity1 , proximal and distal in 1 @entity1 , and distal in 1 @entity1 . Complete occlusion of the @entity439 was achieved in 5 @entity1 , incomplete occlusion in 3 @entity1 , and a small neck remnant in 2 @entity1 . Final angiograms also demonstrated complete clearance of a proximal @entity2473 in 4 @entity1 , and complete clearance of proximal and distal spasms in another 4 @entity1 . Mean initial dose of @entity3931 was 1.375 mg, and mean continuous infusion dose was 1.275 mg (mean total dose, 2.65 mg). No medical complications related to extended infusion of @entity3931 occurred. CONCLUSION: In this small series, extended intra-arterial infusion of @entity3931 up to the end of the embolization procedure was effective and safe in @entity1 with a ruptured @entity439 and associated @entity2553 . This technique seems to increase the security of the procedure as well as force further vasorelaxation when the endovascular route is used to treat both the @entity439 and @entity2553 in a single step.
