XXXX in anti-synthetase syndrome: Initial and follow-up CT findings.

@entity1 @entity5427 @entity82 @entity55 @entity3616 @entity854 @entity4595 @entity401
PURPOSE: To describe the initial and follow-up CT features of @entity401 associated with anti-synthetase syndrome ( @entity5427 ). MATERIALS AND METHODS: Two independent thoracic radiologists retrospectively analysed thin-section CT images obtained at diagnosis of @entity5427 in 33 @entity1 (17 positive for anti-Jo1, 13 for anti-PL12, and three for anti-PL7 antibodies). They evaluated the pattern, distribution and extent of the @entity854 . They also evaluated the change in findings during follow-up (median 27 months; range 13-167 months) in 26 @entity1 . RESULTS: At diagnosis, ground-glass opacities (100%), reticulations (87%) and traction @entity4595 (76%) were the most common CT findings. Consolidations were present in 45% of @entity1 . A @entity401 ( @entity401 ), @entity3616 ( @entity3616 ) or mixed @entity55 pattern were observed in 15 out of 33 (45%), seven out of 33 (21%) and eight out of 33 (24%) @entity1 , respectively, whereas the CT pattern was indeterminate in three @entity1 . During follow-up, consolidations decreased or disappeared in 11 out of 12 @entity1 (92%), among which seven within the first 6 months, but honeycombing progressed or appeared in ten out of 26 @entity1 (38%) and overall disease extent increased in nine out of 26 @entity1 (35%). CONCLUSION: CT features at diagnosis of @entity5427 mainly suggest @entity401 and @entity3616 , isolated or in combination. Consolidations decrease or disappear in most cases but the disease may progress to @entity82 in more than one third of @entity1 .
