Age-associated brain regions in XXXX : a volumetric analysis.

@entity1 @entity11 @entity463 @entity5
Both age of @entity1 and @entity5 location are associated with @entity5 origin, genetic characteristics, and prognosis. The objective of this study was to investigate the relationship between @entity5 location and age at diagnosis in a large cohort of @entity1 with a primary diagnosis of @entity11 . We consecutively enrolled a cohort of 200 adults with @entity463 and another cohort of 200 adults with diffuse low-grade @entity11 . The magnetic resonance images of all @entity5 were manually segmented and then registered to a standard brain space. By using voxel-by-voxel regression analysis, specific brains regions associated with advanced age at @entity5 diagnosis were localized. In the low-grade @entity11 cohort, the brain regions associated with advanced age at @entity5 diagnosis were mainly located in the right middle frontal region, while a region in the left temporal lobe, particularly at the subgranular zone, was associated with lower age at @entity5 diagnosis. In the @entity463 cohort, the brain regions associated with advanced age at @entity5 diagnosis were mainly located in the temporal lobe, particularly at the posterior region of the subventricular zones. A region in the left inferior frontal region was associated with lower age at @entity5 diagnosis. Significant differences in the age of @entity1 were found between @entity5 located in the identified regions and those located elsewhere in both cohorts. The current study demonstrated the correlation between @entity5 location and age at diagnosis, which implies differences in the origin of @entity11 in young and older @entity1 .
