Existence of @entity43883 )- and XXXX subtypes in @entity235 mandibular alveolar arteries.

@entity3160 @entity70673 @entity13397 @entity20399 @entity235 @entity43883 @entity19170 @entity4763 @entity2647 @entity3159 @entity1063
1. The present study attempted to pharmacologically characterize the alpha-adrenoceptor subtypes mediating vasoconstriction in @entity235 isolated and perfused mandibular alveolar artery (MAA). 2. @entity1063 (NA) and @entity2647 (PE) induced a strong vasoconstriction in a dose-dependent manner. The PE-induced vascular constriction was significantly inhibited by treatment with @entity3159 . @entity4763 evoked a moderate vascular constriction and the @entity4763 -induced response was suppressed by @entity3160 . The NA-induced response was partially inhibited by @entity3160 and the remaining response to NA was abolished by subsequent administration of @entity3159 . 3. Treatment of MAA with @entity13397 produced a dose-dependent inhibition of NA-induced vasoconstriction. Pretreatment of tissues with 10 micromol/L @entity19170 produced a slight and statistically significant inhibition of NA-induced responses. @entity20399 , a selective alpha(1D)-adrenoceptor antagonist, failed to significantly affect vasoconstrictor responses to NA. 4. The present results suggests that: (i) both alpha(1)- and alpha(2)-adrenoceptors are involved in vasoconstrictor responses in the @entity235 MAA; and (ii) the alpha(1)-adrenoceptors involved in the vasoconstrictor responses in the MAA are characterized as mainly of the @entity43883 )- and partially of the @entity70673 subtype.
