Exogenous hydrogen sulfide exhibits anti- XXXX effects though @entity1435 MAPK signaling pathway in C6 @entity11 cells.

@entity3958 @entity522 @entity588 @entity589 @entity5 @entity36 @entity1441 @entity11 @entity8835 @entity98 @entity876 @entity1435
UNASSIGNED: It has been documented that @entity3958 , in some types of @entity5 , promotes @entity5 proliferation, whereas, in the other types, it inhibits the @entity5 cell growth. In the present study, we investigated the anti- @entity5 effects and relevant mechanisms of @entity8835 in C6 @entity11 cells. C6 cells were subjected to different concentrations of @entity8835 , then cell viability and morphological changes were examined by @entity98 assay and Hoechst staining. The protein expression of @entity522 , @entity588 , @entity589 , @entity1435 MAPK (mitogen-activated protein kinase), and @entity876 was measured by Western blotting. This work demonstrated that @entity8835 could reduce cell number and induce apoptosis of @entity36 cells. The protein expression of @entity522 and @entity589 was up-regulated, while the protein expression of @entity588 was down-regulated. Additionally, @entity1435 MAPK and @entity876 were activated in response to @entity8835 . Moreover, @entity1435 MAPK inhibitor, @entity1441 , counteracted the inhibitory effect of @entity8835 on C6 @entity11 cells. These data suggest that @entity8835 can effectively reduce cell number of C6 cells by triggering the apoptosis via Caspase-dependent pathway. @entity1435 MAPK and @entity876 play an important role in @entity8835 -induced apoptosis in C6 cells. These findings imply that administration of @entity8835 may represent a new strategy for the treatment of @entity11 .
