Update on antibiotics in XXXX .

@entity5517 @entity2930 @entity114 @entity13135 @entity2886 @entity281 @entity581 @entity378 @entity288
Each year, new antimicrobials are found or synthesized in an effort to improve the chance of overcoming @entity281 . In the early 1950s, the only antibiotic available for ocular use was @entity114 . Today, ophthalmologists can make a choice from a large selection of antibiotics for @entity5517 . The majority of antibiotics have been literally unearthed, since worldwide soil surveys may have been the means of their discovery. In addition, synthetic derivatives of @entity114 , @entity2886 , @entity581 , and @entity2930 , as well as drugs against @entity378 and fungi, have become available, and new names have been added to the already bewildering list of less frequently used @entity13135 . However, it takes several years to appreciate the impact of new agents and the continued contribution of older ones. Constant reevaluation is mandatory. The real benefits as well as the untoward effects of a new antimicrobial agent may not be known until several years after the clinical introduction. In addition to approaching infection from the viewpoint of the offending organism and a specific antibiotic to address this organism, one may also approach this problem from the host's immunity. Until now, we have relied largely on the @entity288 , but one must also consider various nonsteroidal anti-inflammatory agents and, even more importantly, the development of drugs to enhance the host's natural immunity.
