Selective transport between heterogeneous hyphal compartments via the plasma membrane lining septal walls of XXXX .

@entity11150 @entity413 @entity25803
UNASSIGNED: Hyphae of ascomycetes are compartmentalized by septa. The central pore in these septa allows for cytoplasmic streaming. However, many of these pores are closed by Woronin bodies in @entity11150 , which prevents cytoplasmic mixing and thus maintains hyphal heterogeneity. Here, @entity413 uptake and transport was studied in @entity11150 . @entity413 uptake was higher in the hyphal population with high transcriptional activity when compared to the population with low transcriptional activity. @entity413 was transported from the colony center to the periphery, but not vice versa. This unidirectional flow was similar in the wild-type and the   hexA strain that does not form Woronin bodies. This indicated that septal plugging by Woronin bodies does not impact long distance @entity413 transport. Indeed, the @entity413 analogue @entity25803 ( @entity25803 ) translocated to neighboring hyphal compartments despite Woronin body mediated plugging of the septum that separated these compartments. Notably, @entity25803 accumulated in septal cross walls, indicating that intercompartmental @entity413 transport is mediated by transporters that reside in the plasma membrane lining the septal cross-wall. The presence of such transporters would thus enable selective transport between heterogeneous compartments.
