Actions of XXXX and @entity38857 in a simple model of anxiety in @entity19 .

@entity38857 @entity3175 @entity5756 @entity19 @entity3216 @entity1767 @entity4944
A two-compartment activity box is described in which the actions of anxiolytic compounds may be readily detected. The box is designed with a partition which divides a dimly-lit black area and a brightly-illuminated white area. Free access to each section is enabled by means of a small opening in the partition. Measures of locomotion and rearing are recorded as well as transitions from black to white and vice versa. Time spent in each section is also measured. In this situation @entity19 demonstrated a clear preference for the dim black section, a finding not inconsistent with the nocturnal nature of this species. By contrast, treatment with @entity3175 (0.125-5 mg/kg) or @entity5756 (0.01-0.1 mg/kg) produced a significant increase in activity in the white section. Locomotion and rearing in the black section showed a corresponding decrease. @entity3216 (0.5-20 mg/kg) and @entity38857 (0.5-40 mg/kg) had similar effects. These actions would appear to be independent of their effects on general activity, as @entity4944 (1.25-2.5 mg/kg) increased and @entity1767 (0.05-0.2 mg/kg) decreased overall exploratory behaviour in a non-selective manner. These data suggest the "two-compartment activity box" to be a model sensitive to the actions of clinically-active anxiolytics.
