7B.07: CIGARETTE SMOKING REDUCES BLOOD PRESSURE RESPONSE TO ANTIHYPERTENSIVE TREATMENT IN NEWLY DIAGNOSED HYPERTENSIVE XXXX .

@entity1 @entity101 @entity65
OBJECTIVE: Smoking and @entity101 are important risk factors in the development of @entity65 ( @entity65 ). Control rates of @entity101 are quite poor with only <50% of @entity1 achieving target blood pressure (BP) after antihypertensive monotherapy. Smokers may have a blunted response to antihypertensive drugs but this has not been properly investigated. Therefore we studied the interaction between smoking status and BP response in never-treated @entity101 @entity1 . DESIGN AND METHOD: We studied 305 untreated @entity101 subjects (mean age 51  1, mean  SEM, F=124) classified according to their smoking status; non- smoker (n=134), smoker (n=64) and ex- smoker (n=104). Haemodynamic measurements including systolic and diastolic BP and heart rate (HR) were measured before and 1 month after monotherapy with commonly used antihypertensive agents;Data were analyzed using with JMP version 7.1 (SAS) for Windows. Results were expressed as mean  SEM, with p<0.05 considered significant. RESULTS: There was a significant relationship between smoking status and fall in BP; smokers and ex- smokers showed lower reduction than non- smokers for systolic BP (4  1.7 vs. 13.6  1 vs. 17.6  1) and diastolic BP (6.5  1.0 vs. 8.7  0.8 vs. 10  0.7, p<0.01) respectively. In a stepwise regression analysis, baseline systolic BP, smoking status and female gender were the only significant predictors of fall in systolic BP (R2=0.19, p<0.0001) with smokers exhibiting 2mm Hg less fall than smokers and ex-smokers. For reduction in diastolic BP, baseline diastolic BP and smoking status were the only significant predictors R2=0.19, p<0.0001) with smokers showing 2 mmHg less reduction in diastolic BP compared with non- smokers. CONCLUSIONS: Smoking is not only an important @entity65 factor in @entity101 @entity1 but also reduces the response to anti- @entity101 treatment, independent of age, gender and body mass index. Therefore, smoking cessation can achieve not only reduced @entity65 but may also improve BP control in @entity101 @entity1 .
