Effects of acute @entity6635 depletion on raph   functional connectivity in XXXX .

@entity1 @entity308 @entity6635 @entity3756 @entity750
UNASSIGNED: Depression remains a great societal burden and a major treatment challenge. Most antidepressant medications target serotonergic raph   nuclei. Acute @entity6635 depletion (ATD) modulates @entity750 function. To better understand the raph  's role in mood networks, we studied raph   functional connectivity in @entity308 . Fifteen @entity308 @entity1 were treated with @entity3756 for 12 weeks and scanned during ATD and sham conditions. Based on our previous findings in a separate cohort, resting state MRI functional connectivity between raph   and other @entity308 -related regions (ROIs) was analyzed in narrow frequency bands. ATD decreased raph   functional connectivity with the bilateral thalamus within 0.025-0.05Hz, and also decreased raph   functional connectivity with the right pregenual anterior cingulate cortex within 0.05-0.1Hz. Using the control broadband filter 0.01-0.1Hz, no significant differences in raph  -ROI functional connectivity were observed. Post-hoc analysis by remission status suggested increased raph   functional connectivity with left pregenual anterior cingulate cortex in remitters (n=10) and decreased raph   functional connectivity with left thalamus in non-remitters (n=5), both within 0.025-0.05Hz. Reducing @entity750 function appears to alter coordination of these mood-related networks in specific, low frequency ranges. For examination of effects of reduced @entity750 function on mood-related networks, specific low frequency BOLD fMRI signals can identify regions implicated in neural circuitry and may enable clinically-relevant interpretation of functional connectivity measures. The biological significance of these low frequency signals detected in the raph   merits further study.
