Feasibility of induction chemotherapy using bronchial arterial infusion for locally advanced XXXX : a pilot study.

@entity1 @entity66 @entity5 @entity1149 @entity900 @entity204 @entity1349
PURPOSE: We examined the feasibility and effectiveness of bronchial arterial infusion (BAI) as induction chemotherapy before surgery for locally advanced @entity1149 ( @entity1149 ). METHODS: Eighteen @entity1 with locally advanced @entity1149 were given BAI consisting of @entity900 (CDDP) (50-100 mg/m(2)) as induction chemotherapy before surgery (induction BAI). Six @entity1 with clinical stage IIIA @entity5 had bulky N2 metastatic lymph nodes, and 12 @entity1 with clinical stage IIIB @entity5 had @entity66 . RESULTS: Of the 18 @entity1 , 12 (67%) showed a partial response to the BAI therapy. Standard pulmonary resection was performed in 5 @entity1 , pulmonary resection with the combined resection of adjacent organs was performed in 10 @entity1 , and pulmonary resection with carinal resection and reconstruction was performed in 3 @entity1 . Complete resection was possible in 14 @entity1 (78%). There were no serious BAI therapy-related complications or @entity204 . The 5-year survival rate of the 18 @entity1 was 35.7% and the @entity1349 ( @entity1349 ) was 19.4 months. Survival was better when complete resection was achieved after the induction BAI, especially in @entity1 with stage IIIB (T4) disease. CONCLUSION: Based on our preliminary findings, BAI with CDDP as induction chemotherapy is feasible and may be an effective therapeutic modality for locally advanced @entity1149 .
