@entity189 Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for XXXX .

@entity1 @entity2198 @entity124 @entity5 @entity189
PURPOSE: @entity5 with high microsatellite-instable have clinical and pathological features that differentiate them from microsatellite-stable or @entity189 , which was studied rarely in @entity5 , promoting the present investigation of the usefulness of @entity124 status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in @entity5 . @entity1 AND METHODS: Data of 460 @entity1 who underwent primary anterior resection with a double stapling technique for @entity189 at a single institution from 2008 to 2012 were retrospectively collected. All @entity1 experienced a total mesorectal excision (TME) operation. Survival analysis were analyzed using the Cox regression method. RESULTS: Five-year rate of disease-free survival (DFS) was noted in 390 (84.8%) of 460 @entity1 with @entity5 . Of 460 tissue specimens, 97 (21.1%) exhibited @entity2198 . Median age of the @entity1 was 65 (50-71) and 185 (40.2%) were male. After univariate and multivariate analysis, microsatellite instability (p= 0.001), female sex (p< 0.05) and fluorouracil-based adjuvant chemotherapy (p< 0.001), the 3 factors were attributed to a favorable survival status independently. Among 201 @entity1 who did not receive adjuvant chemotherapy, those @entity5 displaying @entity2198 had a better 5-year rate of DFS than @entity5 exhibiting microsatellite stability or low-frequency instability (HR, 13.61 [95% CI, 1.88 to 99.28]; p= 0.010), while in 259 @entity1 who received adjuvant chemotherapy, there was no DFS difference between the two groups (p= 0.145). Furthermore, @entity1 exhibiting microsatellite stability or low-frequency instability who received adjuvant chemotherapy had a better 5-year rate of DFS than @entity1 did not (HR, 5.16 [95% CI, 2.90 to 9.18]; p< 0.001), while @entity1 exhibiting @entity2198 were not connected with increased DFS (p= 0.696). It was implied that female @entity1 had better survival than male. CONCLUSION: Survival status after anterior resection of @entity189 is related to the microsatellite instability status, adjuvant chemotherapy and gender. Fluorouracil-based adjuvant chemotherapy benefits @entity1 of @entity5 with microsatellite-stable or low microsatellite-instable, but not those with high microsatellite- instable. Additionally, free of adjuvant chemotherapy, @entity189 with high microsatellite-instable have a better 5-year rate of DFS than those with microsatellite-stable or low microsatellite-instable, and female @entity1 have a better survival as well.
