Impact of @entity13983 on XXXX -induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages.

@entity632 @entity251 @entity137 @entity1976 @entity39 @entity2310 @entity2041 @entity194 @entity35 @entity13983
The aim of the present study was to investigate whether @entity13983 (EA) has protective effect on @entity632 (ADR)-induced testicular and spermatozoal @entity137 associated with the oxidative stress in male @entity35 . Thirthy-two healthy 8-week-old male @entity35 were equally divided into four groups. The first (EA) group was treated with EA (2 mg/kg/every other day) by gavage. The second (ADR) group received ADR (2 mg/kg/once a week) intraperitoneally, while the combination of ADR and EA was given to the third (ADR+EA) group. The forth (control) group was treated with placebo. At the end of the 8-week treatment period, reproductive organ weights, epididymal sperm parameters, histopathological changes and apoptosis via @entity2310 and @entity1976 proteins, testicular tissue lipid peroxidation, and antioxidant enzyme activities, were investigated. ADR administration was determined to cause significant decreases in reproductive organ weights, epididymal sperm concentration and motility, plasma @entity251 concentration, diameter of seminiferous tubules, germinal cell layer thickness, Johnsen's testicular score and @entity1976 positive antiapoptotic cell rate, wherease it caused significant increases in level of lipid peroxidation and @entity2041 , catalase activity, abnormal sperm rates and @entity2310 positive apoptotic cell rates along with degeneration, @entity39 , immature germ cells, congestion and @entity194 in testicular tissue when compared with the control group. EA administration to ADR-treated @entity35 provided significant improvements in ADR-induced disturbed oxidant/antioxidant balance, decreased @entity251 concentration, testicular apoptosis and mild improvements in the histopathological view of the testicular tissue. However, EA failed to improve decreased reproductive organ weights and deteriorated sperm parameters due to ADR administration. It is concluded that while ADR has direct or indirect (lipid peroxidation) negative effects on sperm structure and testicular apoptosis in @entity35 , EA has protective effects on ADR-induced testicular lipid peroxidation and apoptosis.
