[Clinical study of the effectiveness and tolerance of @entity4258 in the therapy of complicated XXXX and in long-term prevention of recurrent @entity293 ].

@entity1 @entity4258 @entity281 @entity56 @entity293
The efficacy and tolerance of @entity4258 in the treatment of complicated @entity293 and in low dose long-term prophylaxis over six months for recurrent UTI were investigated in 60 and 27 @entity1 , respectively. In the prophylaxis group, compliance with medication was controlled weekly using Mecur BT. Five to nine days after treatment, the urine was sterile in 50 out of the 60 @entity1 treated (83.3%); relapse occurred in six @entity1 and was associated with development of resistance in two. Four @entity1 suffered re- @entity281 within the study period. Failure of treatment was closely related to persisting complicating factors in the urinary tract. The overall tolerance of @entity4258 was satisfactory. However, there was one severe @entity56 . During the total 391 weeks of low dose long-term prophylaxis given to 27 @entity1 , only one break-through @entity281 occurred. Yet compliance studies proved that antimicrobial activity was present in the urines of less than 50% of the @entity1 . During prophylaxis, the rate of @entity281 was reduced from three to four to 0.13 to 0.05 @entity281 / @entity1 /year. There was no development of resistance in the isolates from these @entity1 . Only two adverse reactions were observed.
