Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with XXXX and @entity1670 .

@entity1 @entity12880 @entity1674 @entity1670 @entity412 @entity583 @entity165
Consecutive survivors of a @entity583 from the Southern Hospital, below 70 years of age, were randomized into a Control group (n = 276) and a Treatment group (n = 279). The latter was openly prescribed the combination of @entity12880 and @entity1670 for serum lipid lowering. Each @entity1 should remain in the study for 5 years and be seen regularly every 4 months at a special IHD outpatient clinic within the hospital. The concentration of serum @entity165 and @entity412 was lowered by 13% and 19%, respectively, in the Treatment group compared to the Control group. Total mortality was 82 cases in the Control group and 61 in the Treatment group, a 26% reduction (p less than 0.05). For @entity1 above 60 years of age in the Treatment group the reduction in mortality was 28% (p less than 0.05). IHD mortality was reduced by 36% (p less than 0.01) in the Treatment group compared to the Control group. The beneficial effect of the serum lipid lowering treatment was related to the serum @entity412 concentration in two ways. First, it only occurred in @entity1 with a @entity412 level greater than 1.5 mmol/l (n = 216). Secondly, it was most pronounced in the 44% of the treated @entity1 who had a lowering of the serum @entity412 by 30% or more, and in this subgroup the reduction of IHD mortality was 60% (p less than 0.01). For serum @entity165 there were no such relations. The difference between serum @entity1674 and @entity165 concerning these relations to the treatment outcome may be due to the fact that hypertriglyceridaemia was the most common hyperlipidaemia among our @entity1 , occurring in 50%, while hypercholesterolaemia only occurred in 13%. Caution should be exercised in the interpretation of the results as the trial was not blind. However, the fact that the decrease in IHD deaths was directly related to the degree of serum @entity412 lowering indicates that it was the drug effect on serum lipids that was responsible for the beneficial effect of the treatment.
