XXXX in Infancy Is a Risk Factor for Chronic @entity490 in Childhood.

@entity1 @entity19 @entity2371 @entity344 @entity490 @entity158 @entity293 @entity526
OBJECTIVE:: Adverse early life events are key factors for development of @entity344 ( @entity344 ). @entity293 ( @entity293 ) is associated with chronic @entity2371 in adults, a finding that has been recapitulated in @entity19 models, but the relation between @entity490 has not been studied in @entity1 . We hypothesized that @entity293 in infancy increases the risk of @entity344 and @entity490 ( @entity490 ) in childhood. METHODS:: The present study included @entity1 , ages 4 to 18 years, with a single @entity293 in the first year of life and their siblings with no history of @entity293 . Parents completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) by telephone. @entity1 meeting QPGS-III criteria for @entity344 but with @entity158 less than once weekly were considered to have @entity490 . RESULTS:: A total of 57 @entity1 with @entity293 and 58 sibling controls were identified. Mean age at @entity293 was 4.8 months, and mean time since @entity293 was 9.3 years. At the time of survey, mean age of @entity1 was 9.7 years (5-16 years, 40% @entity1 ) and that of controls was 9.6 years (range 4-17 years, 57% @entity1 ). @entity344 were diagnosed in 6 of 57 (11%) @entity1 , and 1 of 58 (2%) controls (P=0.06). @entity490 was identified in 10 of 57 (18%) @entity1 and 2 of 58 (3%) controls (P=0.02). Predominant sex (female), infecting organism ( @entity526 ), and treatment (third-generation cephalosporin) were similar in @entity1 with @entity293 with and without @entity490 . CONCLUSIONS:: We show for the first time that @entity293 is associated with @entity490 in childhood. We speculate that pelvic organ sensory convergence explains our findings.
