XXXX screening in asymptomatic adults: the role of FDG PET scan.

@entity1 @entity419 @entity5 @entity189 @entity14 @entity652 @entity694 @entity1586
The aim of this study was to evaluate the potential application of @entity419 (FDG) Positron Emission Tomography (PET) for @entity14 screening in asymptomatic individuals. The subjects consisted of 3210 physical check-up examinees (1736 @entity1 , 1474 @entity1 ; mean age +/- SD, 53.2 +/- 8 y) with non-specific medical history. In the control group, 12 @entity1 who had gastrointestinal symptoms with biopsy-proved @entity694 were recruited. Whole-body FDG PET was performed on all @entity1 . Focal hypermetabolic areas with an intensity equal to or exceeding the level of FDG uptake in the brain and bladder were considered abnormal and interpreted as intraluminal @entity5 . Among the 3210 FDG PET examinations, advanced @entity5 was present in 20 examinations, including 2 tubular adenomas larger than 1 cm, 12 @entity5 . Of 6 examinees diagnosed with @entity5 , one had a Dukes stage A lesion, four had Dukes stage B lesion and one had a Dukes stage C lesion. In the control group, of 12 @entity1 with biopsy-proved @entity189 followed by FDG PET scan, six had a Dukes stage B lesion, four had Dukes stage C lesion and two had a Dukes stage D lesion. The mean and standard deviation of standard uptake value (SUV) in @entity1586 and @entity189 is 3.56 +/- 0.68 and 5.74 +/- 2.26, respectively. The sensitivity of using FDG PET in the detection of primary @entity14 is high. Primary @entity14 can be detected with FDG PET in a resectable stage. FDG PET could detect large size (> 0.7 cm) and pre-malignant change of @entity1586 . It is possible to differentiate @entity652 from @entity694 by an increased rate of glycolysis (SUV) in @entity189 .
