Two subtypes of XXXX with @entity16 : the roles of eosinophils and ANCA.

@entity1 @entity1333 @entity39 @entity12534 @entity16 @entity384 @entity28068
The aim of this study was to clarify the differences in the pathogenesis of @entity16 between myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-positive and -negative @entity1 with @entity12534 ( @entity12534 ). Eight MPO-ANCA-positive and 14 MPO-ANCA-negative @entity1 were included. In addition to the standard histology, nerve biopsies were examined, employing immunohistochemistry for @entity28068 and electron microscopy. The groups did not differ significantly in clinical profiles, including the peak disability score and number of blood eosinophils. In nerve biopsies, @entity1333 was found in 63% (5/8) of the ANCA-positive and 21% (3/14) of the ANCA-negative @entity1 . Fibrinoid @entity39 of vessel walls was noted in 4 ANCA-positive @entity1 (50%), and in one ANCA-negative @entity1 (p = 0039). In contrast, a large number of eosinophilic infiltrations in the epineurium was shown in 36% (5/14) of the ANCA-negative @entity1 , with no eosinophilic infiltrations shown in ANCA-positive @entity1 . In 3 ANCA-negative @entity1 , endoneurial eosinophils were seen where focal axonal loss and @entity384 were occasionally noted. There may be 2 pathogenetic mechanisms of @entity16 with @entity12534 : ANCA-related vascular fibrinoid @entity39 , and a toxic eosinophilic effect on nerve fibers which is independent of ANCA. Therapy targeting activated eosinophils may be a possible treatment for intractable @entity16 of @entity12534 .
