Prognostic Role of Serum Levels of XXXX in Amyotrophic Lateral Sclerosis.

@entity1 @entity414 @entity746
BACKGROUND AND PURPOSE: It has been suggested that oxidative stress is one of the pathomechanisms underlying @entity746 ( @entity746 ), and thus antioxidants such as @entity414 (UA) that could reduce oxidative stress might be beneficial in the prevention or treatment of this disease. The objective of this study was to prospectively investigate serum UA levels in Korean @entity746 @entity1 and to relate them to disease progression. METHODS: @entity746 @entity1 and healthy controls who were individually well-matched for sex, age, and body mass index (BMI) underwent blood testing for serum UA levels, and analyzed whether UA levels were correlated with the disease status of the @entity1 , as defined by the @entity746 Functional Rating Scale-Revised (ALSFRS-R). RESULTS: The study included 136 @entity746 @entity1 and 136 matched controls. The UA level was lower in the @entity746 @entity1 (4.50  1.17 mg/dL, mean  SD) than in the controls (5.51  1.22 mg/dL; p<0.001). Among the @entity746 @entity1 , the level of UA acid was inversely correlated with the rate of disease progression (decrease in ALSFRS-R score). Kaplan-Meier analysis revealed that a better survival rate was more strongly correlated with top-tertile levels of serum UA than with bottom-tertile levels (log-rank test: p=0.035). CONCLUSIONS: @entity746 @entity1 had lower serum UA levels than did healthy individuals. UA levels in @entity746 were negatively correlated with the rate of disease progression and positively associated with survival, suggesting that UA levels contribute to the progression of @entity746 . UA levels could be considered a biomarker of disease progression in the early phase in @entity746 @entity1 .
