Polymorphisms in the Promoters of the @entity1476 and XXXX Genes Are Associated with Spontaneous @entity1779 in the Taiwan Population.

@entity1552 @entity1 @entity72510 @entity64 @entity72511 @entity101 @entity6 @entity1476 @entity548 @entity37057 @entity3628 @entity1410 @entity11414 @entity285 @entity1779
BACKGROUND: Spontaneous @entity1779 ( @entity1779 ) is a devastating @entity64 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity1476 and @entity1552 to @entity1779 ( @entity1779 ) susceptibility and @entity1410 size. METHODS: Associations were tested by logistic regression and @entity3628 ( @entity3628 ) where appropriate, adjusting with covariables of age, sex, @entity101 , @entity6 , smoking, and @entity285 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity1779 @entity1 and 376 control subjects in this study. In the elder group, @entity72510 @entity11414 variant in @entity1552 was associated with @entity1779 in male and overall @entity1 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity37057 TT genotype in @entity1476 was correlated to @entity1779 in male @entity1 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity72511 AA genotype in @entity1552 was associated with @entity1779 in female @entity1 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity1 , @entity1779 @entity1 who had @entity548 had significantly lower frequency of AA genotypes in @entity72511 than those with @entity548 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity548 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity72510 variant in the elder female @entity1 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity1 . In younger @entity1 , the @entity548 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity1 . CONCLUSIONS: This study showed a significant association between the variants of @entity1476 and @entity1552 promoters and @entity1779 susceptibility with significant age and gender differences. @entity548 location and size might be affected by @entity1552 promoter variants in the @entity1779 @entity1 .
