Antihypertensive effects of the neutral endopeptidase inhibitor XXXX in essential @entity101 .

@entity73312 @entity1 @entity6708 @entity101 @entity10
The antihypertensive effects and safety of a novel neutral endopeptidase inhibitor, @entity73312 , were investigated in @entity101 @entity1 . A multicenter, open clinical trial was conducted in 27 @entity1 with essential @entity101 , WHO Stage I or II. Mean age was 64 +/- 1 years. After 2 to 4 weeks of a placebo run-in, 50 mg twice daily, was started, with the dose increased to 100 mg twice daily, and 200 mg twice daily, every 2 weeks, if necessary, to achieve a predetermined response. Blood pressure and pulse rate were monitored every 2 weeks. Blood chemistry, plasma atrial natriuretic peptide (ANP), and plasma @entity6708 levels were determined before and after the 8-week treatment period. Blood pressure was significantly reduced, from 171 +/- 1/100 +/- 1 mm Hg to 146 +/- 3/84 +/- 2 mmHg (P < .001) at the end of the 8-week treatment period. No change in pulse rate was noted. Efficacy rate was evaluated in 25 @entity1 treated for 4 weeks or more. Efficacy rate was 44% with 50 mg twice daily, 60% with 100 mg twice daily, and 80% with 200 mg twice daily. Adverse reactions such as @entity10 were observed in six @entity1 (22.2%), with treatment discontinued in five. Significant correlation was observed between increment in plasma ANP levels and blood pressure reductions (r = -0.53, P < .05). Increase in plasma @entity6708 was positively correlated with increments in plasma hANP (r = 0.80, P < .001). @entity73312 has potent antihypertensive effect associated with an enhancement of endogenous hANP and may be clinically useful as a new class of antihypertensive drug.
