The effect of @entity4854 on the @entity5 response to irradiation given alone or in combination with XXXX .

@entity19 @entity5 @entity26 @entity1492 @entity519 @entity413 @entity221 @entity4854
The effect of @entity4854 (elevated blood @entity413 level) on the response of a @entity19 @entity5 to irradiation given alone or in combination with @entity221 was studied. @entity5 were early generation isotransplants of a spontaneous C3H/Sed @entity19 @entity1492 , FSa-II. Single-cell suspensions were transplanted into the foot, and irradiation was given when each @entity5 reached an average diameter of 7 mm. Following irradiation, the @entity5 growth time to reach 1000 mm3 was studied and the dose-response curve between the @entity5 growth time and radiation dose was fitted. Preadministration of @entity413 increased the size of the @entity519 and chronically @entity519 cell fractions without altering the slope of the dose-response curve where the chronically @entity519 cell fraction is determined as the fraction of cells which were not oxygenated under hyperbaric @entity26 conditions. @entity221 given prior to irradiation enhanced the @entity5 response to irradiation, but simultaneously increased the size of the @entity519 and chronically @entity519 cell fractions. Similar results were observed following @entity221 given after irradiation. When @entity221 at 43.5 degrees C was given 24 h before irradiation, the size of the @entity519 cell fraction increased with increasing treatment time, while a substantial decrease in the chronically @entity519 cell fraction was observed. Administration of @entity413 60 min before @entity221 further increased the size of the @entity519 cell fraction. Possible mechanisms explaining why @entity413 administration increases the @entity519 cell fractions are discussed.
