Contribution of XXXX Polymorphisms to Risk of @entity410 : a Multicenter Cohort Study and Meta-analysis.

@entity1 @entity410 @entity1246 @entity71186 @entity71184 @entity71185 @entity71188 @entity302 @entity71187 @entity71189 @entity65316
UNASSIGNED: @entity1246 receptor ( @entity1246 -A) is the most common receptor of fast synaptic inhibition in the @entity1 brain. Gamma protein encoded by the @entity65316 gene is one of the subunits of the @entity1246 -A receptor, which plays an essential role in the function of this receptor. Several studies have identified various @entity410 ( @entity410 ) and @entity302 risk variants of @entity65316 gene in different populations, but some others did not support these results. The aim of this case-control study is to investigate whether @entity65316 polymorphisms contribute to susceptibility for @entity410 and @entity302 in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea. Furthermore, the pooled dataset of these cohorts with previous reports were meta-analyzed for determining the risk effect size of the @entity71184 polymorphism on @entity410 and @entity302 ( @entity302 ). The @entity71184 , @entity71185 , @entity71186 , @entity71187 , @entity71188 , and @entity71189 polymorphisms were genotyped in the 6442 subjects (1729 @entity302 and 4713 controls). Results of the case-control study showed associations between @entity71184 and the risk of @entity302 in the pooled data from all cohorts (T vs. C, p   =   3   *   10(-5), and TT vs. CC, p   =   2   *   10(-5)) and the risk of partial @entity410 in the combined data of Malaysia and Hong Kong (both T vs. C and TT vs. CC, p   =   2   *   10(-6)). The @entity71184 - @entity71185 and @entity71187 - @entity71188 - @entity71189 haplotypes were also associated with susceptibility to @entity302 in Chinese. Meta-analysis of all Asians identified association between @entity71184 and @entity410 and @entity302 (T vs. C, p   =   4   *   10(-4), and p   =   4   *   10(-3), respectively). In conclusion, @entity71184 alone may be a risk factor for @entity410 , partial @entity410 , and @entity302 , and in linkage disequilibrium with @entity71185 can contribute to @entity410 and @entity302 in Asians, particularly in Chinese.
