The Emerging Role of Skeletal Muscle Metabolism as a Biological Target and Cellular Regulator of Cancer-Induced XXXX .

@entity5 @entity6126 @entity2057 @entity121 @entity5653 @entity2383
UNASSIGNED: While skeletal muscle mass is an established primary outcome related to understanding @entity5 mechanisms, considerable gaps exist in our understanding of muscle biochemical and functional properties that have recognized roles in systemic health. Skeletal muscle quality is a classification beyond mass, and is aligned with muscle's metabolic capacity and substrate utilization flexibility. This supplies an additional role for the mitochondria in @entity5 -induced @entity2057 . While the historical assessment of mitochondria content and function during @entity5 -induced @entity121 was closely aligned with energy flux and @entity5653 susceptibility, this understanding has expanded to link mitochondria dysfunction to cellular processes regulating myofiber @entity5653 . The primary objective of this article is to highlight muscle mitochondria and oxidative metabolism as a biological target of @entity5 and also as a cellular regulator of @entity5 -induced @entity2057 . Initially, we examine the role of muscle metabolic phenotype and mitochondria content in @entity5 -induced @entity5653 susceptibility. We then assess the evidence for @entity5 -induced regulation of skeletal muscle mitochondrial biogenesis, dynamics, mitophagy, and oxidative stress. In addition, we discuss environments associated with @entity5 that can impact the regulation of skeletal muscle oxidative metabolism. The article also examines the role of cytokine-mediated regulation of mitochondria function regulation, followed by the potential role of @entity5 -induced @entity6126 . Lastly, a role for decreased muscle use in @entity5 -induced @entity2383 is reviewed.
