OFF midget bipolar cells in the retina of the marmoset, @entity7533 , express XXXX receptors.

@entity162 @entity2227 @entity1735 @entity4176 @entity140 @entity7533
Recent studies suggested that different types of OFF bipolar cells express specific types of ionotropic ( @entity140 or @entity4176 ) @entity2227 receptors (GluRs) at their contacts with cone pedicles. However, the question of which GluR type is expressed by which type of OFF bipolar cell in primate retina is still open. In this study, the expression of @entity140 and @entity4176 receptor subunits at the @entity162 (FMB) cells was analyzed in the retina of the @entity7533 , @entity7533 . We used preembedding electron microscopy and double immunofluorescence with subunit-specific antibodies. The FMB cells were labeled with antibodies against the @entity1735 epitope CD15. Cone pedicles were identified with peanut agglutinin. Immunoreactivity for the GluR1 subunit and for CD15 is preferentially located at triad-associated flat contacts. Furthermore, the large majority of GluR1 immunoreactive puncta is localized at the dendritic tips of FMB cells. These results suggest that FMB cells express the @entity140 receptor subunit GluR1. In contrast, the @entity4176 receptor subunit GluR5 is not colocalized with the dendritic tips of FMB cells or with the GluR1 subunit. Immunoreactive puncta for the GluR1 subunit are found at all M/L-cone pedicles but are only rarely associated with S-cone pedicles. This is consistent with our recent findings in marmoset retina that FMB cells do not contact S-cone pedicles. The presence of GluR5 clusters at S-cone pedicles indicates that in primate retinas OFF bipolar cells expressing @entity4176 receptor subunits receive some S-cone input.
