Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae XXXX on @entity344 .

@entity9135 @entity2928 @entity344 @entity112 @entity13575 @entity33689 @entity18307 @entity35085
Fructus Aurantii Immaturus and Radix Paeoniae @entity2928 Powder ( @entity18307 ) is a popular Chinese herbal prescription. The combination of Fructus Aurantii Immaturus and Radix Paeoniae @entity2928 has been used to treat @entity344 for hundreds of years. To our interest, this combination shows a bilateral effect on gastrointestinal peristalsis. Our present study was focused on the bilateral role of this combination on the gastrointestinal tract. The effective constituents and mechanisms were explored. Six monomer constituents from Radix Paeoniae @entity2928 and Fructus Aurantii Immaturus were screened by intestinal transit assay. The bilateral roles of three effective constituents were authenticated by gastric emptying assay, and the combination of three constituents showed a bilateral effect. Then, the mediating receptors and the role of NO and @entity9135 were examined to determine the mechanism involved. The overall results suggest that the major effective constituents of this combination are @entity33689 , @entity35085 and @entity13575 . @entity33689 inhibits the @entity344 , while @entity35085 stimulates it. @entity13575 shows different effects on intestinal and gastric activity. The effect of @entity33689 relies on the alpha-adrenergic receptor, and the effect of @entity35085 is mediated via the H1 @entity112 receptor. The regulation of @entity35085 and @entity33689 on NF- kappaB @entity9135 translocation and NO production through the alpha-receptor and the H1 receptor, respectively, is involved in the bilateral effect of the Fructus Aurantii Immaturus-Radix Paeoniae @entity2928 combination.
