Burden of Norovirus and Rotavirus in XXXX after Rotavirus Vaccine Introduction, Cochabamba, Bolivia.

@entity1 @entity294 @entity697 @entity5163
UNASSIGNED: The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of @entity5163 affecting @entity1 worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes the prevalence of norovirus and rotavirus 2 years after widespread rotavirus vaccination in Cochabamba, Bolivia. Stool samples from hospitalized @entity1 with @entity697 ( @entity697 ) and outpatients aged 5-24 months without @entity697 were recruited from an urban hospital serving Bolivia's third largest city. Both viruses were genotyped, and norovirus GII.4 was further sequenced. Norovirus was found much more frequently than rotavirus. Norovirus was detected in 69/201 (34.3%) of specimens from @entity1 with @entity697 and 13/71 (18.3%) of those without @entity294 . Rotavirus was detected in 38/201 (18.9%) of diarrheal specimens and 3/71 (4.2%) of non-diarrheal specimens. Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P[8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P[4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in @entity1 after widespread vaccination against rotavirus.
