Increased DNA methyltransferase 1 protein expression correlates significantly with intestinal histological type and gender in XXXX .

@entity1 @entity20480 @entity5 @entity356 @entity15894 @entity16610
PURPOSE: Promoter hypermethylation and reduced expression of many genes have been found in @entity356 . DNA methyltransferases are enzymes potentially affecting promoter hypermethylation. MATERIAL AND METHODS: We analyzed proteins expression of DNA methyltransferase 1 and 3b by immunohistochemistry in 47 surgically resected @entity356 samples for which clinicopathological characteristics, @entity1 's outcome and methylation status of 11 selected @entity5 -related genes have been determined. Promoter methylation status of genes was assessed by methylation specific PCR. RESULTS: We found that @entity20480 were up-regulated in @entity356 and were detected in 51.1% and 57.4% of cases, respectively. Co-expression of @entity20480 was detected in 44.7%. Correlations analysis have showed that @entity16610 overexpression was significantly correlated with @entity356 of intestinal histological type (P=0.01) and with gender of @entity1 (P=0.01). However, there was no correlation between @entity16610 and @entity15894 overexpression in @entity5 and @entity1 outcome. Moreover, there were no clear relations between the proteins expression of @entity20480 and DNA methylation status of genes. But co-expression of @entity16610 and @entity15894 was significantly associated with promoter hypermethylation of RAR-b2 (P=0.04). CONCLUSIONS: Results from our study indicate that @entity20480 were overexpressed and could be involved in gastric tumorigenesis of intestinal histological type in the case of Tunisian @entity1 .
