Preoperative radiotherapy in combination with @entity868 for resectable XXXX : long-term results of a phase 2 study.

@entity1 @entity137 @entity868 @entity5 @entity189 @entity356
AIM: Surgery remains the main treatment of @entity189 . Poor long-term survival mandates the study of other techniques. An original treatment scheme with preoperative radiotherapy and @entity868 as a radiosensitizer is reported here. METHODS: Between 1982 and 1988, MRRC RAMS carried out a prospective clinical trial of preoperative radiotherapy (20 Gy/5 days) in combination with @entity868 (given orally, 3 times, 5 gms per metre(2)). Of 91 @entity1 who received preoperative radiotherapy, 67 @entity1 were operated on with curative intent and were eligible for further analysis. RESULTS: Acute gastro-intestinal @entity137 was significant but manageable without surgery delay in most cases. There were 4 postoperative deaths. Overall 5-year, 10-year survival and median survival were 46%, 36% and 46 months. Serosal and nodal involvement were the most significant adverse prognostic factors. Tumours confined to the gastric wall, node negative cases, middle and distal location, differentiated @entity5 , female sex and age more than 50 years were associated with relatively good long-term results: overall 5-year survival was 50% or better, overall 10-year survival was 40% or better. CONCLUSION: The combined treatment showed significant but manageable acute @entity137 . The long-term results seem encouraging and support further investigations in multimodal treatment of @entity356 .
