The course of social cognitive and metacognitive ability in XXXX : Deficit are only partially normalized after full remission of first episode major @entity308 .

@entity1 @entity73 @entity308
OBJECTIVES: Research has suggested that @entity1 suffering from @entity308 ( @entity308 ) experience deficits in the related domains of social cognition and metacognition. Most research has focused on detecting deficits among @entity1 who are acutely symptomatic. Thus, little is known about whether these deficits persist after symptoms have remitted. As a first, this study investigated social @entity73 in @entity1 with @entity308 in the acute and remitted state. DESIGN: Longitudinal case-control. METHODS: Forty-four drug-na  ve @entity308 @entity1 and an equal number of matched healthy controls were assessed in multiple domains of social cognition including theory of mind, social perception, and metacognition. Additionally, a comprehensive neurocognitive (non-social) test battery was utilized. Following baseline assessment, @entity1 were enrolled in an outpatient treatment programme. @entity1 reaching remission within 6  months (n  =  29) were reassessed 6  months post-remission. Included for analysis were only @entity1 who followed a course of remission (n  =  29) and their paired healthy controls (n  =  29). RESULTS: Analyses of variance revealed that remitted @entity1 performed significantly better at retest than at baseline on nearly all measures. These effects withstood adjusting for test-retest effects. Moreover, remitted @entity1 performed up to level of healthy controls on some but not all social cognitive tasks and metacognition at retest. CONCLUSIONS: Overall, results suggests that social cognitive and metacognitive ability may improve with symptom remission in major @entity308 although it may not reach a level equal to @entity1 who have never experienced @entity308 . PRACTITIONER POINTS: Many with @entity308 experience @entity73 . When @entity308 remits, social cognition may improve. After remission, first-episode @entity308 @entity1 may still experience @entity73 . We have yet to determine whether social @entity73 existed prior to the onset of @entity308 . Longer-term longitudinal studies of social cognition in @entity308 are needed. Treatment was pharmacological and non-manualized psychotherapy, the effects of which were not controlled for. Sample sizes were modest, which must caution against generalization of the results.
