Serum XXXX values in erythrocytoses and in primary thrombocythaemia.

@entity1 @entity6582 @entity548 @entity1307 @entity4406 @entity715
Serum @entity1307 ( @entity1307 ) values were estimated in samples from 125 @entity1 with @entity6582 to examine the specificity and sensitivity of reduced and raised values in the diagnosis of @entity4406 ( @entity4406 ) and @entity6582 ( @entity6582 ) respectively. Additionally, @entity1307 values were estimated in samples from 49 @entity1 with primary thrombocythaemia (PT) to determine whether @entity1307 values were altered. We found high specificity (92%) and moderate sensitivity (64%) of low serum @entity1307 values (below the reference range) in the diagnosis of @entity4406 , and also poor sensitivity (47%) of raised @entity1307 values in the diagnosis of @entity6582 . Raised @entity1307 values were not observed in @entity4406 @entity1 with Hb > 14.0 g/dl and were only observed in one @entity4406 @entity1 with a relatively low Hb recovering from a gastro-intestinal @entity548 . Raised @entity1307 values occurred in some @entity1 with @entity6582 ( @entity6582 ) and @entity6582 ( @entity6582 ), mainly at normal (rather than raised) Hb values (< 16 g/dl). Low @entity1307 values occurred in a few @entity6582 , @entity6582 and @entity6582 @entity1 at higher Hb values (> 16 g/dl). Low @entity1307 values were less specific for @entity4406 when the Hb was raised, while raised @entity1307 values were less specific for @entity6582 when the Hb was not raised. Approximately one third of @entity1 with PT had a low (below the reference range) @entity1307 value, this being associated with a high normal Hb (> 14 g/dl, P < 0.001) and showing a trend towards association with absence of treatment. The high normal Hb values were in turn associated with an increased incidence of @entity715 events (P < 0.05). These findings could influence the future investigation and management of PT @entity1 .
