T cell XXXX receptor governs antigen-elicited @entity60 production.

@entity59 @entity738 @entity19 @entity409 @entity60 @entity10501 @entity58 @entity13306 @entity9749
@entity10501 (SP) enhances antigen-dependent T cell @entity60 production. It was determined if a T cell @entity13306 ( @entity13306 ) was critical for @entity60 regulation. T cells from schistosome-infected @entity19 were mixed with splenocytes from uninfected @entity13306 knockout (KO) animals. Thus only the schistosome egg antigen-specific T cells expressed @entity13306 . The cells were cultured 18 h with or without SP. SP enhanced antigen-induced @entity60 production fourfold without affecting @entity58 or @entity59 secretion. @entity13306 inhibitor blocked this stimulation. Neither purified T cells nor naive KO splenocytes cultured alone responded to antigen. To further define the importance of T cell @entity13306 , we developed a T cell-selective @entity13306 KO @entity19 by reconstituting T cell-deficient Rag @entity19 with @entity13306 KO T cells. These @entity19 challanged with @entity409 . @entity738 size was smaller in T cell-selective @entity13306 KO @entity19 compared with @entity738 in Rag reconstituted with normal T cells. Splenocytes and @entity738 cells from @entity13306 KO @entity19 made less @entity60 . The @entity19 also made less @entity9749 . Thus T cell @entity13306 is important for @entity60 regulation.
