[Effects of defibrinogenase on photochemically induced @entity2500 in @entity64 -prone renovascular hypertensive XXXX ].

@entity5045 @entity64 @entity548 @entity2500 @entity2792 @entity1188 @entity35 @entity715 @entity385
OBJECTIVE: To investigate the effects of intravenous injection of defibrinogenase on dissoliving dissolve @entity715 and salvaging @entity385 in @entity64 -prone @entity2792 @entity35 (RHRSP) with @entity2500 (MCAO). METHODS: The MCAO in RHRSP was induced by administration in photosensitive dye, rose bengal, and irradiation of the main MCA with a focus laser beam. The @entity715 in MCA and @entity385 were examined microscopically in HE stained sections. @entity1188 size was determined in @entity5045 stained sections. Defibrinogenase was injected intravenously at 3, 6, 9, 12 hours and 3, 7 days after MCAO, meanwhile the control group received normal saline. All @entity35 were killed at 72 hours and evaluated by pathological methods after treatment. RESULTS: In the treatment group, the thrombi were dissolved totally at 3 hours after MCAO, 75% at 6 hours, 13% at 9 hours. Defibrinogenase failed to dissolve @entity715 beyond 12 hours after MCAO, just as control group. In comparison with the control group, defibrinogenase significantly reduced @entity1188 size. There was no evidence of @entity548 . CONCLUSIONS: Defibrinogenase can reduce @entity1188 size and dissolve @entity715 in 6 hours after MCAO without the side effect of @entity548 .
