The severity of inflammation at onset of XXXX is not associated with IBS-like symptoms during clinical remission.

@entity1 @entity31 @entity344
BACKGROUND AND AIMS: Symptoms compatible with irritable bowel syndrome (IBS) are common in @entity1 with @entity31 (UC) in clinical remission. It has been suggested that these symptoms might arise due to post-inflammatory changes comparable with post-infectious IBS. The aim was to study factors at new onset of UC that predict development of IBS-like symptoms during clinical remission. METHODS: In total, 98 @entity1 with new onset of UC were followed prospectively for 3 years with yearly follow-up visits. Data from the first visit at the onset of UC were compared between a group of @entity1 who fulfilled the criteria for IBS while in remission (UCR+IBS) during follow-up and a group who did not (UCR-IBS). RESULTS: Among the UC @entity1 , 87 met the criteria for clinical remission and 25 (29%) of these reported IBS-like symptoms in remission during follow-up. There was no difference in inflammatory disease activity at the initial flare or in the prevalence of previous IBS symptoms when comparing UCR+IBS and UCR-IBS @entity1 . The UCR+IBS @entity1 reported more severe @entity344 , including abdominal pain, during their primary flare. CONCLUSION: The severity and extent of inflammation at onset of UC do not seem to affect the development of IBS-like symptoms in UC @entity1 during clinical remission. The high prevalence of IBS-like symptoms is not explained by pre-existing IBS. UCR+IBS @entity1 reported more severe @entity344 at disease onset, which might indicate a more sensitive gastrointestinal tract in this category of @entity1 .
