The effect of topically applied salicylic compounds on @entity750 -induced scratching behaviour in hairless XXXX .

@entity1 @entity3785 @entity39593 @entity70576 @entity117 @entity70577 @entity22743 @entity111 @entity750 @entity112 @entity35
There is a strong need for antipruritic substances for treating itch in clinical dermatology. In one recent @entity1 study, topically applied @entity117 has been described to rapidly decrease @entity112 -induced itch. We have established a model for periferally elicited @entity111 by injecting @entity750 into the rostral back area (neck) in @entity35 . Using this model, we aimed to investigate the antipruritic potential of four different salicylic compounds, which all possess different skin penetration characteristics. Eighteen @entity35 were studied for 6 weeks. Prior to @entity750 injections (2 mg/ml, 50 micro l), 10 micro l of test substances was applied to a circular area 18 mm in diameter. The four substances were @entity3785 , @entity70576 , @entity70577 and @entity22743 , all solubilized in @entity39593 to a concentration of 5% w/w. @entity70577 and @entity22743 were previously shown to be slowly absorbed through @entity35 skin in contrast to @entity3785 and @entity70576 . After @entity750 injections, scratching was monitored by video recording for 1.5 h. Compared with the vehicle, a lower number of scratch sequences were seen when @entity70577 (P < 0.001) and @entity22743 (P = 0.005) had been applied. The numbers of scratch sequences were lower with @entity70577 and @entity22743 than with the vehicle throughout the 1.5-h study period. We conclude that topical application of @entity70577 and @entity22743 could suppress @entity750 -induced scratching in rats. The antipruritic effect seems to be related to the slow drug release of the two substances. The results may be clinically relevant as @entity750 induces itch in @entity1 .
