P-170 Glycoprotein (MDR) and @entity876 Expression in XXXX .

@entity1 @entity0 @entity5 @entity2802 @entity876 @entity7895
An immunohistochemical comparative analysis of P-170 glycoprotein and @entity876 was performed in 37 @entity0 @entity1 who underwent curative resection without preoperative chemotherapy. The antibodies utilized were C-219 and JSB-1 for @entity7895 and DO-7 for @entity876 . Positive cytoplasmic and membrance positivity for @entity7895 was found in 22 (59.45%) of the 37 @entity5 specimens. In comparing tissue immunoreactivity by the specific antibodies, 15 (40.54%) samples showed immunostaining for C-219, 12 (32.43%) for JSB-1, and 5 (23%) for both. @entity7895 expression was not statistically related with the clinicopathological variables analyzed, that is, age, @entity2802 stage, histologic type, lymph node involvement, @entity5 diameter, and hormone receptor status. @entity876 overexpression was observed in 22 (59.45%) of the 37 @entity5 samples analyzed. There was a significant correlation between @entity876 overexpression and @entity7895 positive immunostaining (p = .007). @entity876 was also significantly correlated with @entity2802 stage (p < .05) and lymph node involvement (p < .02). Our results demonstrated that the three distinct patterns of reactivity with the two antibodies result from the combined expression of each of the three @entity7895 isoforms. An immunohistochemical analysis with different antibodies may be used to determine and correlate the expression pattern of @entity7895 isoforms with response to chemotherapy.
