Allergic airway @entity32 disrupts interleukin-17 mediated host defense against XXXX @entity281 .

@entity748 @entity1 @entity32 @entity7940 @entity66 @entity14293 @entity19 @entity2260 @entity2348 @entity281 @entity9701 @entity358 @entity56 @entity2258 @entity636 @entity328
UNASSIGNED: Despite decreasing rates of invasive @entity66 caused by vaccine serotypes, the prevalence of invasive @entity2258 in @entity748 @entity1 remains high. However, little is known about the mechanisms underlying the susceptibility of the @entity748 airway to @entity2348 . In this study, we used a combined model of @entity56 airway @entity32 and @entity328 @entity358 to investigate the association between persistent @entity32 in the airway and antibacterial host defenses against @entity2260 . When challenged with @entity2260 , @entity56 @entity19 exhibited higher airway bacterial burdens, greater eosinophil infiltration, lower neutrophil infiltration, and more severe structural damage than non- @entity56 @entity19 . In sensitized @entity19 , @entity2260 @entity281 elicited higher IL-4 but lower IFN-y, @entity636 and defensin-b2 expression than in control @entity19 . These results indicate that persistent @entity32 impaired airway host defense against @entity2260 is associated with the insufficient @entity636 responses. To elicit @entity636 induced-anti-bacterial immune responses, @entity19 were intranasally immunized with @entity7940 . Immunized @entity19 exhibited fewer bacterial colonies in the respiratory tract and less severe lung pathology than unimmunized @entity19 . @entity7940 contributed to airway host defense enhancement and innate immune response promotion, which was associated with increased @entity14293 , @entity9701 and defensin-b2 expression. Administration of exogenous @entity636 (2 g/ @entity19 ) suppressed eosinophil-related immune responses. The results demonstrate @entity636 plays a key role in host defenses against @entity2348 and suggest that exogenous @entity636 administration promotes the anti-becterial immune responses and attenuates the existed @entity32 .
