Inhibition of vascular response in XXXX by crude aqueous extract of the root bark of zanthoxylum xanthoxyloides.

@entity32 @entity11574 @entity19 @entity2647 @entity35 @entity3352
BACKGROUND: The root bark extract of Zanthoxylum xanthozyloides is used in folklore medicine in Ghana and Nigeria to treat @entity32 . A previous pharmacological study confirmed the anti-inflammatory activity of the extract. OBJECTIVE: To study the effect of the extract on vascular response in @entity32 . METHOD: The extract was obtained by Soxhlet extraction and rotatory evaporation, followed by freeze-drying. Groups of @entity35 (with carrageenin-induced paw @entity32 ) and @entity19 (with @entity11574 -induced @entity32 ) were, respectively, assigned randomly to treatment groups. The animals were given three different treatments orally: 0.9% saline (control), the extract (400mg/kg and 800mg/kg for @entity19 ; 1000mg/kg, 2000 mg/kg, and 4000mg/kg for @entity35 ), and @entity3352 (5mg/kg and 10mg/kg for @entity19 ; 10mg/kg, 20mg/kg, and 40mg/kg for @entity35 ). In another set of experiment, each treatment group received @entity2647 subcutaneously (30  g/kg for @entity35 and 20  g/kg for @entity19 ) in addition to the specified treatment aforementioned. In both sets of experiments, each group of @entity35 was rotated through the entire treatment groups such that each animal served as control as well as received all the treatments. Analysis of variance was used as the statistical test. RESULTS: The extract and @entity3352 both caused dose-dependent reduction in the carrageenin-induced increase in paw volume in @entity35 and also reduced @entity11574 -induced increase in blood flow in @entity19 pinna arteries. @entity2647 enhanced the decrease in capillary permeability and vasodilatation caused by low dose extract but not that caused by high dose extract or both low and high dose @entity3352 . CONCLUSION: The extract reduced vasodilatation and decreased capillary permeability in @entity32 .
