9A.03: XXXX AND @entity2159 ACTIVATE MONOCYTES INTO ANTI-INFLAMMATORY PROPERTIES IN THE @entity1 WITH HYPERTENSION-RELATED VASCULAR CALCIFICATION.

@entity1 @entity101 @entity5750 @entity11772 @entity1096 @entity729 @entity2935 @entity543 @entity2159
OBJECTIVE: Monocytes/macrophages are believed to play roles in @entity729 (VC). Here, we analyzed whether @entity1096 ( @entity1096 ) and @entity2159 ( @entity2159 ) might exert effects by promoting macrophage polarization into an anti-inflammatory phenotype in the @entity1 with @entity101 ( @entity101 )-related VC.(Figure is included in full-text article.) DESIGN AND METHOD:: In this study, 412 @entity101 @entity1 with or without VC were identified by using artery electronic calculators tomography(fig 1). Histological analysis was performed in the samples of aortic blood vessel from calcified vessels. @entity1 peripheral blood @entity5750 + monocytes including M1   like @entity2935 + and M2   like @entity11772 + cells were analysised by flow cytometery. The effects on M1 and M2 macrophages corrlated with cytokines and chemokines were assessed by qPCR. RESULTS: We show that in @entity101 @entity1 ,VC was correlated with higher systolic pressure,the higher incidence and more intima-media thickness of the @entity543 and was associated with arterial stiffness(including higher carotid-femoral pulse wave velocity, aortic systolic pressure, augment pressure, augment index(P<0.05)). Furthermore, The phenotype of M1   like monocyte/macrophages was significantly increasesd in @entity101 @entity1 with VC (P<0.05)(Fig 3). Although both Serum @entity1096 and @entity2159 levels increased in @entity101 @entity1 with VC, they significantly upregulated anti-inflammatory M2 macrophages marks (P<0.05) and only @entity1096 downregulated pro-inflammatory M1 macrophages marks. CONCLUSIONS: The phenotype of M1 macrophages and M2 macrophages is promoted by VC(fig 2). The ability of @entity1096 and @entity2159 to promote differentiation of macrophages into an alternative, anti-inflammatory phenotype may explain their protective effects in VC of @entity101 @entity1 . These data provide novel insight into the link between inflammtion and VC diseases.
