Long-term survival after resection of XXXX : a single-center retrospective analysis.

@entity1 @entity788 @entity5 @entity3
AIM: To retrospectively analyze factors affecting the long-term survival of @entity1 with @entity788 who underwent pancreatic resection. METHODS: From January 2000 to December 2011, 195 @entity1 underwent pancreatic resection in our hospital. The prognostic factors after pancreatic resection were analyzed in all 195 @entity1 . After excluding the censored cases within an observational period, the clinicopathological characteristics of 20 @entity1 who survived >=  5 (n = 20) and < 5 (n = 76) years were compared. For this comparison, we analyzed the @entity1 who underwent surgery before June 2008 and were observed for more than 5 years. For statistical analyses, the log-rank test was used to compare the cumulative survival rates, and the    (2) and Mann-Whitney tests were used to compare the two groups. The Cox-Hazard model was used for a multivariate analysis, and P values less than 0.05 were considered significant. A multivariate analysis was conducted on the factors that were significant in the univariate analysis. RESULTS: The median survival for all @entity1 was 27.1 months, and the 5-year actuarial survival rate was 34.5%. The median observational period was 595 d. With the univariate analysis, the UICC stage was significantly associated with survival time, and the CA19-9  <= 200 U/mL, DUPAN-2  <= 180 U/mL, @entity5 size  <= 20 mm, R0 resection, absence of lymph node @entity3 , absence of extrapancreatic @entity3 , and absence of portal invasion were favorable prognostic factors. The multivariate analysis showed that @entity5 size  <= 20 mm (HR = 0.40; 95%CI: 0.17-0.83, P = 0.012) and negative surgical margins (R0 resection) (HR = 0.48; 95%CI: 0.30-0.77, P = 0.003) were independent favorable prognostic factors. Among the 96 @entity1 , 20 @entity1 survived for 5 years or more, and 76 @entity1 died within 5 years after operation. Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2 (79.5 vs 312.5 U/mL, P = 0.032), @entity5 size  <= 20 mm (35% vs 8%, P = 0.008), R0 resection (95% vs 61%, P = 0.004), and absence of lymph node @entity3 (60% vs 18%, P = 0.036) were significantly associated with the 5-year survival. CONCLUSION: Negative surgical margins and a @entity5 size  <= 20 mm were independent favorable prognostic factors. Histologically curative resection and early @entity5 detection are important factors in achieving long-term survival.
