Adulthood Weight Change and Risk of XXXX in the Nurses' Health Study and Health Professionals Follow-up Study.

@entity1 @entity14
UNASSIGNED: We investigated the association between adulthood weight change and @entity14 risk in a prospective study with 24 to 34 years of follow-up among 90,988 @entity1 and 46,679 @entity1 . The primary exposures included weight change from early adulthood (age = 18 years for @entity1 , 21 years for @entity1 ) to baseline enrollment (median age = 43 years for @entity1 , 52 years for @entity1 ), and from baseline to present. In the secondary analyses, we also assessed 4-year weight change during follow-up, and during premenopausal (from age 18 years to menopause) and postmenopausal (from menopause to present) periods in @entity1 . Compared to @entity1 maintaining their weight from age 21 to baseline, those who gained 20 kg or more were at a higher risk of @entity14 (relative risk [RR], 1.64; 95% confidence interval [CI], 1.15-2.35, P trend < 0.001), whereas those who lost 8 kg or more had a lower risk (RR, 0.61; 95% CI, 0.30-1.22, P trend = 0.003). Similar but weaker associations were found in @entity1 and the corresponding RRs were 1.38 (95% CI, 1.13-1.69, P trend < 0.001) and 0.80 (95% CI, 0.58-1.09, P trend = 0.21). Weight change from baseline to present was not associated with @entity14 risk. Four-year weight change during follow-up was positively associated with @entity14 risk in @entity1 (P trend = 0.03) but not in @entity1 (P trend = 0.42). In addition, in @entity1 , weight change before, but not after, menopause was associated with @entity14 risk. Our findings provide further scientific rationale for recommendations to maintain a healthy body weight during adulthood. A potential differential association according to sex and timing of weight change warrants further investigation. Cancer Prev Res; 8(7); 1-8.   2015 AACR.
