The burden of illness of XXXX .

@entity1 @entity393 @entity309 @entity65
It is necessary to understand the full burden of illness of a disease before the value of interventions can be assessed. @entity309 ( @entity309 ) has an impact on a variety of stakeholders, including @entity1 , healthcare systems, and society as a whole. This overview discusses the societal and @entity1 perspectives, distinguishing several domains of impact. Epidemiology is important from a societal perspective, as it affects the total impact on health and costs related to @entity309 and influences healthcare organization priorities. Co-morbidities, such as @entity65 , are important factors contributing to the impact of @entity309 . The impact on health is, naturally, relevant to both @entity1 and society as a whole, and is summarized by health-related quality-of-life measures from the point of view of the @entity1 and by utilities from the societal perspective. Similarly, work participation is important for both @entity1 and society. Withdrawal from the labor force and short- and long-term sick leave are extensively studied in @entity309 and lead to substantial productivity costs at the societal level and to @entity393 for @entity1 . In addition, the recent concept of presenteeism, which reflects the problems that @entity1 experience while at work, is considered. Finally, the costs of illness of @entity309 are summarized. Societal costs are mainly driven by the costs of drug treatment and inpatient care, including surgery. @entity1 and family costs are mainly driven by the need for formal and informal care. Overall, @entity309 has a significant impact on the health of and costs to @entity1 and society, suggesting that effective interventions to reduce the impact are of value.
