@entity3884 -rich water attenuates amyloid b-induced @entity137 through upregulation of @entity4093 - @entity16389 by stimulation of XXXX -activated protein kinase in SK-N-MC cells.

@entity137 @entity3884 @entity4093 @entity16389 @entity26 @entity179 @entity8582 @entity195 @entity528 @entity2359
UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity179 such as @entity195 ( @entity195 ). Previous evidence suggests Ab-induced @entity2359 is linked to the stimulation of reactive @entity26 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity195 . Recently, @entity3884 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity528 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity137 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8582 -activated protein kinase (AMPK) in a @entity4093 ( @entity4093 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity16389 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity2359 .
