Quantifying exposure to @entity460 and @entity1391 in @entity454 ; predictive of XXXX on top of @entity4288 ?

@entity1 @entity78 @entity16 @entity1391 @entity460 @entity731 @entity121 @entity4288 @entity454
BACKGROUND: Long-term exposure to hypercalcaemia and hyperphosphataemia leads to media calcification and predicts mortality in @entity1 with @entity454 ( @entity454 ). It is debatable whether this exposure is only a risk factor for @entity4288 , or also for superimposed @entity731 . @entity78 exposure is difficult to quantify, because it is variable in time and exerts its deleterious effects only after prolonged presence. METHODS: In 90 dialysis @entity1 , @entity460 and @entity1391 values from the complete dialysis period were collected. From three-month averages, measures for @entity78 exposure were derived after exclusion of transplant periods. @entity78 exposure was then related to @entity121 ( @entity121 ) and to ankle-brachial index (ABI) as markers of early @entity731 . RESULTS: @entity78 exposure was quantified in three ways using 1670 @entity1 -quarters (i.e. three-months periods) covering 93% of the time on dialysis: averaged @entity78 exposure, percentage of time with above-reference values, and burden of hypercalcaemia/hyperphosphataemia represented by this percentage multiplied by months on dialysis. No association was found with @entity121 . @entity1 with increased, not decreased, ABI had higher @entity78 exposure throughout dialysis treatment: hyperphosphataemia burden was 31 (19 to 43) months for @entity1 with ABI between 0.90 and 1.40 and 79 (58 to 100) months for @entity1 with ABI >1.40 or incompressible ankle arteries (p<0.001). CONCLUSION: These findings do not support the hypothesis that @entity78 exposure leads to atherosclerotic changes on top of @entity4288 in @entity454 , and confirm its role in causing @entity16 leading to increased arterial stiffness and incompressible ankle arteries. The used tool for quantifying @entity78 exposure is easy to apply and can properly weigh the complete exposure during @entity454 .
