[Chemosensitivity of @entity1 gastrointestinal and breast cancer xenografts in XXXX ].

@entity1 @entity72491 @entity19 @entity5 @entity1139 @entity16229
Experimental chemotherapies for 15 @entity1 @entity5 xenografted into @entity19 were performed using 14 anticancer agents including 6 drugs in clinical use. Treatment with each single agent was performed for every @entity5 line using the maximum tolerated dose through continuous daily (antimetabolites) or intermittent (cytocidal agents) schedules. Effectiveness of each drug was evaluated by inhibition rate (IR) calculated from mean @entity5 weights of both treated and untreated groups. Response to a treatment was judged as effective when the IR was higher than 58%. Response rate of each drug was as follows; @entity1139 was 67%, UFT 67%, CPA 47%, @entity16229 40%, ACNU 33%, ADR 27%, SOAz 87%, 5'-DFUR 80%, MXT 20%, @entity72491 17%, M-83 17%, CAM 0% and GANU 0%. Generally, the experimental results for each drug on the xenografts was in good accordance with the known clinical effect of each drug on the same type of @entity5 . On the other hand, individual @entity5 xenografts showed considerable differences in chemosensitivity. Some @entity5 were sensitive to a majority of the drugs, whereas some were resistant to many of them. Each @entity5 line seemed to retain individuality in its spectrum of chemosensitivity irrespective of whether it originated from the same organ or whether it was of similar histologic type. This fact suggests the necessity of selecting drugs effective to the individual @entity5 when considering a @entity1 chemotherapy regime.
