The effects of @entity19642 on the cardiovascular system of the XXXX .

@entity1169 @entity19642 @entity935 @entity235 @entity1897 @entity1767 @entity16917 @entity551
The cardiovascular effects of @entity19642 and @entity935 were compared in the anaesthetized and conscious @entity235 by the use of intravenous infusions over the dose range 3 X 10(-9) - 10(-7)mol kg-1 min-1. In the anaesthetized @entity235 , @entity19642 produced a dose-related @entity551 due to @entity1897 and a small rise in heart rate and contractility. By contrast, @entity935 did not significantly reduce blood pressure but produced a larger dose-related increase in contractility. At the highest infusion rate (10(-7)mol kg-1 min-1) blood pressure and heart rate were increased by @entity935 . @entity19642 dilated the renal and mesenteric vascular beds with a potency similar to that of @entity935 . Femoral vascular responses produced by both agents were inconsistent but the highest infusion rate of @entity935 did produce vasoconstriction. With the aid of selective receptor antagonists ( @entity1767 , @entity1169 and @entity16917 ) the vasodepressor activity of @entity19642 was shown to be mediated by stimulation of DA2-, beta- and DA1-receptors. The cardiac stimulation and renal vasodilatation produced by both compounds were due to stimulation of beta-adrenoceptors and DA1-receptors respectively. In the conscious @entity235 , intravenous infusion of @entity19642 caused a dose-related @entity551 , renal vasodilatation and an increase in cardiac contractility and heart rate. @entity935 also increased cardiac contractility, and renal blood flow due to renal vasodilatation but without affecting heart rate. At the highest infusion rate, blood pressure was increased. @entity19642 and @entity935 produced a similar incidence of panting and repetitive licking at 3 X 10(-8)mol kg-1 min-1 and emesis at 10(-7)mol kg-1 min-1, due to stimulation of @entity935 receptors in the chemoreceptor trigger zone. @entity19642 produces a different cardiovascular profile from @entity935 in the anaesthetized and conscious @entity235 . Both compounds reduce renal vascular resistance, but in contrast to @entity935 , @entity19642 reduces afterload and produces only mild inotropic stimulation. These differences reflect contrasting activity at adrenoceptors.
