XXXX suppository for transrectal ultrasound-guided biopsy of the prostate: a prospective, double-blind, randomized study.

@entity1 @entity5 @entity653 @entity3303 @entity158 @entity1486
AIMS: To investigate analgesia using @entity3303 suppositories for prostate biopsy. METHODS: From 2007 to 2009, 160 @entity1 underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 @entity1 received a 60-mg @entity3303 suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 @entity1 received a glycerin suppository as placebo. The @entity158 level was evaluated using a visual analogue scale (VAS). RESULTS: There were no statistically significant differences between the groups, i.e. they were similar regarding @entity1 ' age, @entity1486 levels, prostate volume and the incidence of diagnosis of @entity5 on biopsy. The mean @entity158 score in the @entity3303 group (3    1) was significantly lower than the mean @entity158 score in the @entity653 group (4.1    1.3) (p < 0.001). A noticeable trend towards lower @entity158 scores in the @entity3303 group was observed with more time elapsing from placing the suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository. CONCLUSIONS: @entity3303 suppositories are an easy-to-use, self-applicable (by the @entity1 ) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant.
