XXXX and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold.

@entity2289 @entity556 @entity1003 @entity2786 @entity2106
For rehabilitation training it is recommended that the intensity of exercise should be clearly below the individual anaerobic threshold (IAT). We investigated @entity1003 , particularly endogenous @entity556 potential (ETP) and fibrinolysis following a standardized treadmill (TR) ergometer test at 90% IAT for 60-120 min. Sixteen healthy male non-smokers underwent the TR test. Blood samples were taken after a 30-min rest, immediately after exercise, and 2 h after exercise completion. Extrinsic and intrinsic total ( @entity2106 (ex+in)) and endogenous (ETP(ex+in)) @entity556 potential, prothrombin fragment 1+2 (F1+2), @entity556 -antithrombin complex (TAT), plasmin-alpha2-antiplasmin complex (PAP), D-dimer, tissue plasminogen activator antigen and activity (tPA-AG and tPA-ACT) and plasminogen activator inhibitor type 1 antigen and activity ( @entity2289 -AG and @entity2289 -ACT) were measured. Immediately after TR, F1+2, TAT and @entity2106 (ex+in) were increased ( P<0.05) while ETP(ex+in) remained unchanged. In contrast, @entity2786 , D-dimer, tPA-AG, tPA-ACT ( P<0.05) were distinctly enhanced while @entity2289 -ACT was decreased ( P<0.05) immediately after exercise. The changes in tPA-AG, tPA-ACT, and @entity2289 -ACT were reversed to nearly baseline while the enhancement in PAP and D-dimer was prolonged by more than 2 h after exercise. Long-duration exercise between 60 and 120 min controlled by IAT (90%) on a TR ergometer only implicates a small increase in @entity556 generation markers and total (free and alpha(2)-macroglubulin-bound @entity556 ), but not in endogenous (free) @entity556 potential alone. In contrast, fibrinolysis is distinctly increased after this type of exercise. Endurance exercise with an intensity below 90% IAT and a duration below 2 h generates a more favourable condition for fibrinolysis than for @entity1003 in healthy young subjects. Data are given as mean (SD).
