A superantigen hypothesis for the pathogenesis of chronic @entity1244 with XXXX .

@entity1244 @entity32 @entity1 @entity137 @entity1127 @entity794 @entity364 @entity1412 @entity480 @entity130
BACKGROUND: The pathogenesis of chronic @entity1244 with @entity1412 is still an enigma; however, the molecular biology of this disease is beginning to become unraveled and the proinflammatory cytokines and the message and the product of these cytokines have all been identified in @entity480 . However, the initial trigger that causes @entity32 of the lateral wall of the nose to up-regulate lymphocytes and eosinophils is still unknown. METHODS: Thirteen @entity1 with massive @entity1412 were studied. The mucus of the nasal cavities surrounding the @entity480 was studied for both @entity364 . The lymphocytes of the @entity480 were extracted and evaluated for the T-cell receptor, particularly, the variable beta region of this receptor. Enterotoxins (superantigens) of the bacteria were studied. Finally, the histopathology of @entity480 was studied. RESULTS: Fifty-five percent of the @entity1 had toxin-producing @entity794 in the nasal mucus adjacent to the @entity1127 . Three different enterotoxins were isolated, including @entity794 enterotoxin A, @entity794 enterotoxin B, and @entity137 toxin 1. The variable B specificity for these superantigens was identified also in the polyp lymphocyte T-cell receptor. CONCLUSION: A superantigen hypothesis for massive @entity1412 is suggested because the most common bacterial species found in the nasal mucus is @entity794 . These bacteria produce enterotoxins in all of the cases studied and the corresponding variable beta region of the T-cell receptor also was up-regulated in the polyp lymphocytes in cases studied thus far. These data taken together suggest that the @entity130 to the lateral wall of the nose may be the result of toxin-producing Staphylococci. Superantigens (enterotoxins) may up-regulate lymphocytes to produce cytokines that are responsible for the massive up-regulation of lymphocytes, eosinophils, and macrophages, the three most common inflammatory cells found in @entity1412 .
