XXXX -induced @entity2224 : protection afforded by the @entity460 antagonist verapamil.

@entity63 @entity235 @entity2072 @entity5828 @entity2224 @entity460 @entity299 @entity741 @entity943
There is increasing evidence that the use of @entity2072 can trigger lethal @entity299 , including @entity2224 . The mechanism responsible for these lethal @entity943 remains to be determined. Therefore, 13 mongrel @entity235 were instrumented so that heart rate, left ventricular pressure (LVP), and d(LVP)/dt could be measured. After a 3- to 4-wk recovery period, the left circumflex coronary artery was occluded for 2 min, beginning with the last minute of an exercise stress test and continuing for 1 min after the cessation of exercise. None of the @entity235 developed @entity943 during the control exercise plus @entity63 test. On a subsequent day, the test was repeated after the injection of @entity2072 @entity5828 (1.0 mg/kg). @entity2072 significantly (P less than 0.01) elevated heart rate, systolic LVP, and d(LVP)/dt, and it elicited @entity943 in 12 of the 13 animals during the exercise plus test. In fact, 11 animals developed @entity2224 . Verapamil, a @entity460 channel antagonist (250 micrograms/kg), attenuated the hemodynamic effects of @entity2072 and prevented the development of @entity943 . These data suggest that @entity2072 can induce @entity2224 during @entity741 and that these lethal @entity943 may be prevented by a @entity460 channel antagonist.
