Neurogenic regulation of proximal XXXX and @entity2865 reabsorption.

@entity972 @entity308 @entity1219 @entity1372 @entity3157 @entity5993 @entity2865 @entity35
Although a change in renal nerve activity is known to alter proximal reabsorption, it is unclear whether reabsorption of @entity5993 or @entity1219 or both are affected. @entity35 (n = 10) were studied using free-flow micropuncture techniques during euvolemia and following acute ipsilateral denervation. Glomerular filtration rate and single nephron glomerular filtration rate were stable. Absolute proximal @entity3157 reabsorption fell following denervation (933 +/- 40 to 817 +/- 30 pmol/min) with a parallel reduction in @entity2865 reabsorption (1,643 +/- 116 to 1,341 +/- 129 peq/min). Urinary @entity1372 , @entity972 , @entity3157 , and @entity2865 excretion all increased significantly. To further assess the physiological significance of neurogenic modulation of proximal transport, other @entity35 (n = 6) were subjected to acute unilateral nephrectomy (AUN). There is evidence that AUN induces a contralateral natriuresis (renorenal reflex) at least partially by causing inhibition of efferent renal nerve traffic. AUN caused significant changes in proximal @entity5993 and @entity1219 reabsorption as well as in whole kidney electrolyte excretion in the same pattern as had denervation. Prior denervation of the remaining kidney prevented the proximal and whole kidney response to AUN (n = 6). In conclusion, @entity308 of renal nerve activity inhibits both @entity5993 and @entity1219 reabsorption in the @entity35 superficial proximal convoluted tubule. The data are consistent with the hypothesis that changes in renal nerve activity modify whole kidney electrolyte excretion under physiological conditions at least partially by regulating proximal transport.
