New aspects in shear-wave elastography of XXXX .

@entity1 @entity263 @entity5 @entity11179
AIM: This study was designed to evaluate the performance of shear-wave elastography as a diagnostic tool for @entity263 in a larger cohort of @entity1 than previously reported. @entity1 AND METHODS: Seventy-three @entity1 with suspected @entity263 were investigated by ultrasound elastography followed by directed biopsy. The elastographic and histological results for all biopsies were compared. RESULTS: After exclusion of invalid and non-assessable results, 794 samples were obtained for which both a histological assessment and an elastometric result (tissue stiffness in kPa) were available: according to the histology 589 were benign and 205 were malignant. Tissue elasticity was found to be weakly correlated with @entity1 's age, @entity11179 level and gland volume. ROC analysis showed that, for the set of results acquired, elastometry did not fulfil literature claims that it could identify malignant @entity5 with high sensitivity and specificity. However, it did show promise in distinguishing between Gleason scores  <=6 and >6 when @entity5 had already been identified. Unexpected observations were the finding of a smaller proportion of @entity5 in the lateral regions of the prostate than generally expected, and also the observation that the elasticity of benign prostate tissue is region-sensitive, the tissue being stiffest in the basal region and more elastic at the apex. CONCLUSIONS: Shear-wave elastography was found to be a poor predictor of @entity5 , but for malignant lesions an elasticity cut-off of 80 kPa allowed a fairly reliable distinction between lesions with Gleason  <=6 and those with Gleason >6. We demonstrate an increase in elasticity of benign prostate tissue from the basal to the apical region.
