Blood lipid and lipoprotein concentrations and XXXX risk in the European Prospective Investigation into @entity5 and Nutrition.

@entity1 @entity32 @entity5 @entity167 @entity1674 @entity755 @entity1675 @entity14 @entity694 @entity165
OBJECTIVE: To examine the association between serum concentrations of total @entity165 , high density lipoprotein @entity165 (HDL), low density lipoprotein @entity165 , @entity1674 , @entity1675 (apoA), @entity755 and the incidence of @entity14 ( @entity14 ). DESIGN: Nested case-control study. SETTING: The study was conducted within the European Prospective Investigation into @entity5 and Nutrition (EPIC), a cohort of more than 520,000 @entity1 from 10 western European countries. @entity1 : 1238 cases of incident @entity14 , which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status. MAIN OUTCOME MEASURES: Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, @entity167 , fibre and energy. RESULTS: After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of @entity694 (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of @entity5 . Additional adjustment for biomarkers of systemic @entity32 , insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of @entity694 . CONCLUSIONS: These findings show that high concentrations of serum HDL are associated with a decreased risk of @entity694 . The mechanism behind this association needs further elucidation.
