Hemodynamic effects of @entity460 channel blockers at rest and during exercise in essential XXXX .

@entity1 @entity64 @entity101 @entity1855 @entity460 @entity594 @entity551
The main hemodynamic disturbance occurring in @entity1 with essential @entity101 is an increase in the total peripheral resistance. In young @entity1 with @entity101 , this disturbance is clearly seen during muscular exercise, even though the calculated resistance might be normal during rest. This article reports results of studies on the long-term hemodynamic effects of two @entity460 channel blockers, @entity1855 and @entity594 , in @entity1 with mild to moderate @entity101 . Twenty-five @entity1 , aged 20 to 64 years, with diastolic blood pressures between 100 and 120 mm Hg before treatment were studied at rest and during exercise on ergometer bicycles. Blood pressure was recorded intra-arterially, and cardiac output was measured. After this initial study, 10 @entity1 were treated with @entity1855 (from 40 to 80 mg, three times daily) and 15 @entity1 with @entity594 (long-acting form, from 40 to 80 mg daily). After one year, the hemodynamic study was repeated. Both drugs induced a @entity551 and in the total peripheral resistance without any reduction in the cardiac index. @entity1855 reduced heart rate, particularly during exercise, but this effect was compensated by an increase in the @entity64 volume. The hemodynamic profile of these two @entity460 channel blockers clearly differs from the hemodynamic effects of beta blockers.
