The higher the number of daily doses of antibiotic treatment in XXXX the worse the compliance.

@entity1 @entity3405 @entity5176 @entity7187 @entity56 @entity1729
BACKGROUND: To assess the drug compliance observed among @entity1 with @entity1729 treated with once-daily, twice-daily and thrice-daily antibiotic regimens. METHODS: We performed a prospective study in the primary care setting including @entity1 with suspected @entity1729 , not @entity56 to @entity3405 antimicrobials, @entity7187 or @entity5176 , treated with several antibiotic regimens. @entity1 compliance was assessed by electronic monitoring. RESULTS: A total of 251 @entity1 were enrolled (136 in the thrice-daily group, 70 in the twice-daily group and 45 in the once-daily group). The mean container openings ranged from 94.3 +/- 12.6% with once-daily antibiotics to 74.8 +/- 17.7% with thrice-daily drugs (P < 0.001). Seventy-five @entity1 in the thrice-daily group took at least 80% of the medications (55.1%), being significantly less than those receiving twice-daily (71.4%) or once-daily (86.7%; P < 0.001) drugs. Only 20.6% of the @entity1 assigned to the thrice-daily regimens opened the container every 8 +/- 4 h during at least 80% of the course. Among the @entity1 assigned the same number of doses daily, compliance was better with the shortest antibiotic courses, being worse with schedules of 7 days or more. The percentage of @entity1 who opened the MEMS container the satisfactory number of times a day was lower among the thrice-daily regimens. Moreover, the thrice-daily group more frequently forgot the afternoon dose. CONCLUSIONS: The rate of compliance was very low, mainly when antibiotics were administered thrice daily and in regimens of 7 days or more. New strategies addressed to improve antibiotic drug compliance are, therefore, necessary.
