A study of the potential for a herbicide formulation containing XXXX and picloram to cause male-mediated developmental toxicity in @entity35 .

@entity14462 @entity4642 @entity786 @entity600 @entity35
Male Vietnam veterans have repeatedly expressed concern that exposure to herbicides in Vietnam may have caused @entity600 in their offspring. The second most used herbicide was a mixture of @entity14462 and picloram called Agent White. This study is an investigation into the possible male-mediated reproductive toxicology of this herbicide. Male @entity35 were gavaged for 5 days per week for 9 weeks with a mixture of @entity14462 and picloram called Tordon 75D(R) (the Australian derivative of Agent White). Three doses were tested; the high dose was considered the maximum tolerated dose. Each male was mated with two untreated females during weeks 2 and 3, 4 and 5, and 8 and 9 of treatment, and with four untreated females after an 11-week recovery period. Negative controls were males dosed with distilled water, and positive controls were males dosed with @entity786 at 5.1 mg/kg/day. All mated females were killed on day 20 of gestation, and the fetuses were weighed and examined for either structural @entity600 or skeletal development. Litter size, fetal weight, and @entity600 rate were all unaffected by treatment. The @entity786 positive controls showed the expected large increase in postimplantation loss. In general, within the limitations of the power of the study, the results did not show any evidence that exposure to a herbicide formulation containing @entity14462 and @entity4642 is likely to cause male-mediated @entity600 or other adverse reproductive outcomes.
