Addition of XXXX versus increasing diuretics in moderate but deteriorating @entity712 : a double-blind comparative trial.

@entity1 @entity3371 @entity712 @entity1483
In 15 @entity1 with moderate @entity712 not completely controlled on digoxin (0.25 mg o.d.) and @entity1483 (25 mg o.d.), we compared the addition of @entity3371 (12.5 to 50 mg b.i.d.) with increasing doses of @entity1483 (25 to 100 mg o.d.), in a randomized double-blind, double-dummy, comparative trial. Thirteen @entity1 completed the 3 months study: two dropped-out in the @entity1483 group. Statistically significant clinical improvement occurred in both treatment groups. Exercise tolerance also significantly improved in both groups in a parallel fashion. Echocardiographic cardiac function data showed a significantly better pattern of changes in the @entity3371 group. The addition of low doses of @entity3371 to basal therapy seems to be as effective as the addition of high doses of @entity1483 in uncontrolled moderate @entity712 . This approach with @entity3371 also appears to be more physiological and safe.
