XXXX and @entity7 serum levels in Tunisian Arab @entity1 with suspected @entity1468 .

@entity1 @entity7309 @entity7 @entity7500 @entity1468
UNASSIGNED: The angiogenic factors @entity7 ( @entity7 ) and @entity7309 ( @entity7500 ) play a central role in the process of angiogenesis. We evaluated the association of free @entity7500 and free @entity7 levels and the risk of @entity1468 ( @entity1468 ) among Tunisian Arab @entity1 , and established the range of @entity7 and @entity7500 in normal healthy pregnancies, between 24 and 42weeks of gestation. This retrospective case-control study included 345 @entity1 with @entity1468 , and 289 @entity1 with uncomplicated pregnancies. @entity7500 and @entity7 plasma levels were quantitated by commercially-available ELISA. Compared to control @entity1 , plasma @entity7500 concentrations were lower in @entity1 with @entity1468 at all gestation age intervals (P<0.0001), compared to @entity7 levels which were significantly lower in @entity1 with @entity1468 but only during early gestation age intervals ([29-32[ and [32-35[). High odds for developing @entity1468 , and correspondingly higher associations, were associated with low @entity7500 values (less than the 5(th) percentile), at all gestation age intervals. The only exception was recorded for the [29-32 [interval, which was not statistically significant. @entity7500 testing, recorded at 29-37weeks of gestation, had a higher specificity (93-100%) than sensitivity, and the positive predictive values ranged from 90% to 100% for 24-37weeks of gestation. This indicates that it mainly detects non- @entity1468 healthy @entity1 as well, and thus may be useful as a screening test, though currently unreliable for diagnostic purposes. Reduced @entity7500 levels during different gestation age intervals, and reduced @entity7 levels during early gestation age intervals are also associated with subsequent development of @entity1468 in our population; the gestational age interval adjusted-5(th) percentiles of @entity7500 provide reference ranges for this marker in normal pregnancy.
