@entity10353 of the XXXX : clinical and histologic characteristics and their impact on disease progression.

@entity1 @entity135 @entity5 @entity957 @entity1491 @entity3 @entity10353 @entity942
OBJECTIVES: @entity10353 ( @entity10353 ) is a rare @entity5 entity, and the most common onset is in the @entity135 region ( @entity10353 -HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are @entity942 . This study aimed to evaluate risk factors for local relapse (LR) and lymph node @entity3 (LNM) and their impact on progression-free survival (PFS). MATERIALS AND METHODS: In a retrospective monocentric study, @entity1 with @entity10353 -HN treated between 1999 and 2011 were analyzed regarding clinical and histologic characteristics. Prognostic parameters for LR, LNM, and PFS were evaluated. In total, 89 @entity1 (55 male, 34 female, mean age of 71.8 years) with a mean follow-up time of 47.7 months (range 12-112) were included. RESULTS: LR occurred in four @entity1 (4.5%), LNM occurred in five @entity1 (5.6%). @entity1 with LNM had a significantly shorter PFS time (16.1 months) compared with @entity1 without LNM (154.2 months; P < .001). @entity5 depth and size (T classification), incomplete resection, localization at the ear, deep maximal vertical infiltration, muscle and vessel invasion all showed significant (P < .05) associations with LR, LNM, and shorter PFS time. @entity10353 showed more histologic features of @entity1491 ( @entity1491 ), especially with regard to BerEP4 expression. CONCLUSION: While histology shows some typical characteristics of @entity1491 , the biologic behavior and aggressiveness of @entity10353 are similar to those of @entity957 . This is the first study to show that LR and, especially, LNM indicate a higher risk of an unfavorable outcome.
