Hyaluronic acid-tagged XXXX nanoparticles in @entity694 therapy: therapeutic efficacy evaluation.

@entity137 @entity5 @entity1759 @entity3440 @entity694 @entity1445 @entity1487 @entity4023
@entity694 is one of the leading causes of @entity5 worldwide, and the therapeutic application of @entity1487 ( @entity1487 ) is limited due to its nonspecificity, low bioavailability, and @entity1445 . The present study is an attempt to improve the chemotherapeutic efficacy of @entity1487 in @entity694 . Therefore, we have prepared @entity1487 -loaded hyaluronic acid (HA)-conjugated @entity3440 nanoparticles (SiNPs) to target to @entity694 cells. In this study, we have showed the specific binding and intracellular accumulation of targeted nanoparticles based on HA surface modifications in @entity694 cells. The particles had spherical shapes with sizes of approximately 130 nm. HA-conjugated nanoparticles showed a sustained release pattern for @entity1487 and continuously released for 120 hours. We have further investigated the @entity137 potential of targeted and nontargeted nanoparticles in colo-205 @entity5 cells. IC50 value of @entity1487 / @entity4023 -conjugated @entity3440 nanoparticles (HSNP) was 0.65   g/mL compared with ~2.8   g/mL for @entity1487 /SNP after 24 hours of incubation. The result clearly showed that HA-conjugated NP was more effective in inducing apoptosis in @entity5 cells than nontargeted NP. The @entity1487 /HSNP showed ~45% of cell apoptosis (early and late apoptosis stage) compared with only 20% for @entity1487 / @entity3440 nanoparticles (SNP)-treated group. The HA-conjugated nanoparticles provide the possibility of efficient drug transport into @entity5 that could effectively reduce the side effects in the normal tissues. @entity1487 /HSNP was highly efficient in suppressing the @entity5 growth in xenograft @entity5 model. The proportion of Ki67 in @entity1487 /HSNP-treated group was significantly lower than that of either free drug or nontargeted SiNPs. Altogether, we have showed that conjugation of HA to SiNPs could result in enhanced uptake of @entity1487 through @entity1759 -mediated endocytosis uptake and could result in significant antitumor efficacy. Thus, @entity1487 /HSNP could be a promising drug delivery system for @entity694 therapy.
