Meta-analysis of immunohistochemical prognostic markers in resected XXXX .

@entity1 @entity788 @entity589 @entity588 @entity986 @entity7 @entity470 @entity876 @entity1594
BACKGROUND: The potential prognostic value of several commonly investigated immunohistochemical markers in resected @entity788 is variably reported. The objective of this study was to conduct a systematic review of literature evaluating @entity876 , @entity986 , @entity1594 , @entity588 , @entity589 , @entity7 ( @entity7 ) and @entity470 ( @entity470 ) expression as prognostic factors in resected @entity788 and to conduct a subsequent meta-analysis to quantify the overall prognostic effect. METHODS: Relevant literature was identified using Medline, EMBASE and ISI Web of Science. The primary end point was overall survival assessed on univariate analysis. Only studies analysing resected @entity788 were eligible for inclusion and the summary log(e) hazard ratio (logHR) and variance were pooled using an inverse variance approach. Evidence of heterogeneity was evaluated using the   (2) test for heterogeneity and its impact on the meta-analysis was assessed by the I(2) statisic. Hazard ratios greater than one reflect adverse survival associated with positive immunostaining. RESULTS: @entity7 emerged as the most potentially informative prognostic marker (11 eligible studies, n=767, HR=1.51 (95% confidence interval, CI=1.18-1.92)) with no evidence of any significant publication bias (Egger's test, P=0.269). @entity588 (5 eligible studies, n=314, HR=0.51 (95% CI=0.38-0.68)), @entity589 (5 studies, n=274, HR=0.63 (95% CI=0.48-0.83)) and @entity986 (3 studies, n=229, HR=0.63 (95% CI=0.43-0.92)) also returned significant overall survival differences, but in smaller @entity1 series due to a lack of evaluable literature. Neither @entity876 (17 studies, n=925, HR=1.22 (95% CI=0.96-1.56)), @entity1594 (5 studies, n=540, HR=0.88 (95% CI=0.61-1.27)) nor @entity470 (4 studies, n=250, HR=1.35 (95% CI=0.80-2.27)) was found to represent significant prognostic factors when analysing the pooled @entity1 data. There was evidence of significant heterogeneity in four of the seven study groups. CONCLUSION: These results support the case for immunohistochemical expression of @entity7 representing a significant and reproducible marker of adverse prognosis in resected @entity788 .
