PEGylated thermo-sensitive XXXX dendritic drug delivery systems.

@entity23207 @entity137 @entity21454 @entity3352 @entity1683 @entity21455 @entity970
Thermo-sensitive dendrimers hold promise in various biomedical and pharmaceutical applications due to their stimuli-responsive properties. However, for such systems there are still certain unaddressed issues e.g. the undesired @entity137 , immunogenicity and short blood circulation time. PEGylation is a potential approach to solve these above problems. The aims of this study were to engineer PEGylated thermo-sensitive dendritic derivatives and to investigate their temperature sensitivity and drug release behaviour therein. Linear @entity1683 ( @entity1683 ) and @entity23207 ( @entity23207 ) were attached to the surface of @entity21454 ( @entity21455 ) dendrimers to generate @entity21455 -g- @entity1683 and @entity21455 -g- @entity1683 -co- @entity970 . @entity21455 -g- @entity1683 exhibited the lowest critical solution temperature (LCST) of ca. 32  C, whereas @entity21455 -g- @entity1683 -co- @entity970 showed a LCST of ca. 35  C. @entity3352 was used as a model molecule to examine the drug release profiles from both types of dendritic polymers. Results showed that such thermo-sensitive @entity21455 derivatives could manipulate drug release simply by controlling the temperature above or below the LCST. At 37  C a prolonged drug release was obtained for both systems with less than 30% of drug was released over 12 h, whilst the release rate is much faster at 30  C and ca. 90% of drug was released over 12 h. The results obtained suggest that these thermo-sensitive @entity21455 derivatives could be potential drug delivery systems to achieve controlled drug release.
