Highly Significant Association between Two Common Single XXXX Polymorphisms in @entity13381 Gene and Preeclampsia in Caucasian @entity1 .

@entity1 @entity71780 @entity71781 @entity377 @entity1592 @entity1468 @entity563 @entity13381
Preeclampsia is a frequent medical complication during pregnancy. @entity13381 , a @entity563 protease which activates pro-atrial natriuretic peptide, has recently been shown to be involved in the pathophysiology of @entity1468 . The aim of this study was to search for @entity13381 gene variations and their association to @entity1468 in Caucasian and African @entity1 . Our study population was composed of 571 pregnant @entity1 (295 with @entity1468 and 276 normotensive controls) matched for maternal and gestational age, and ethnic origin. The 22 exons of the @entity13381 gene were sequenced in a discovery sample (n=260), where 31 single @entity377 polymorphisms were identified. In a replication sample (n=311), 4 single @entity377 polymorphisms were tested. Two minor alleles (C for @entity71780 and G for @entity71781 ) were significantly associated to @entity1468 . Adjusted odds ratios [95% confidence interval] were 2.5 [1.2-3.8] (p=0.007) and 2.3 [1.5-3.5] (p=1.3*10-4), respectively. These associations were ethnic-specific, as only found in the Caucasian of subjects (odds ratio=3.5 [1.8-6.6], p=1.1*10-4; odds ratio=3.1 [1.7-5.8], p=2.1*10-4, for each single @entity377 polymorphism, respectively). The two single @entity377 polymorphisms are in almost perfect linkage disequilibrium (r2=0.93). No specific association was found with severe @entity1468 , early-onset @entity1468 nor @entity1592 . In conclusion, this is the first report of a highly significant association between these two single @entity377 polymorphisms in @entity13381 gene and @entity1468 . Our findings further support the probability of a critical role of @entity13381 in preeclamspia pathophysiology at the uteroplacental interface.
