Linac radiosurgery for brain XXXX of @entity320 .

@entity1 @entity137 @entity5 @entity75 @entity3 @entity320
PURPOSE: To evaluate the efficacy and @entity137 of stereotactic radiotherapy in the treatment of brain metastases of @entity320 . @entity1 AND METHODS: From 1994 to 2001, 25 @entity1 presenting with 61 metastases of cutaneous @entity320 were treated with radiosurgery. Median age was 47 years (range: 25-73 years) and median Karnofski performance status 80 (range: 50-100). Twenty @entity1 had one radiosurgery, 5 had two or three. Median @entity3 diameter was 21 mm (range: 6-54.4 mm), and median @entity3 volume was 1.7 cm(3) (range: 0.4-25.6 cm(3)). Irradiation was delivered by a linear accelerator. Median minimal dose was 14.1 Gy (range: 10-19.4 Gy), and median maximal dose was 20.5 Gy (range: 16-48 Gy). RESULTS: Mean follow-up was 12.6 months (range: 1-85 months). Five metastases progressed (9.8%), 2-12 months after radiosurgery. Three-, 6- and 12-month local control rates were 95 +/- 3, 90 +/- 5 and 84 +/- 7%, respectively. By univariate analysis, only absence of extracranial @entity5 was a prognostic factor of local control. Three-, 6- and 12-month @entity75 -free survival rates were 75 +/- 9, 68 +/- 11 and 38 +/- 13%, respectively. According to univariate analysis, only the Score Index for Radiosurgery in brain metastases (SIR) was a prognostic factor of brain-event-free survival (p = 0.03). Median survival was 8 months. Three-, 6- and 12-month overall survival rates were 75 +/- 9, 53 +/- 10, and 29 +/- 10%, respectively. According to univariate analysis, extracranial controlled disease status (p = 0.03), and SIR (p = 0.04) were prognostic factors for overall survival. According to multivariate analysis, none was an independent prognosticator for overall survival. Complications were minimal. CONCLUSION: Radiosurgical treatment of brain metastases of @entity320 is effective and accurate. The use of radiosurgery alone is an appropriate management strategy for many @entity1 with brain metastases of @entity320 .
