Modulatory influence of XXXX receptors on consolidation of object recognition memory.

@entity11640 @entity10095 @entity935 @entity3826 @entity35 @entity2344 @entity11641
The role of @entity935 receptors in regulating the formation of recognition memory remains poorly understood. Here we show the effects of systemic administration of @entity935 receptor agonists and antagonists on the formation of memory for novel object recognition in @entity35 . In Experiment I, @entity35 received an intraperitoneal (i.p.) injection of vehicle, the selective D1 receptor agonist @entity2344 (1.0 and 5.0mg/kg), or the D2 receptor agonist @entity11640 (1.0 and 5.0mg/kg) immediately after training. In Experiment II, @entity35 received an injection of vehicle, the @entity935 receptor antagonist @entity10095 (0.1 and 0.05 mg/kg), or the D2 receptor antagonist @entity11641 (0.5 and 0.1mg/kg) before training, followed by an injection of vehicle or the nonselective @entity935 receptor agonist @entity3826 (0.05 mg/kg) immediately after training. @entity2344 at 5mg/kg produced an enhancement of novel object recognition memory measured at both 24 and 72 h after training, whereas the dose of 10mg/kg impaired 24-h retention. Posttraining administration of @entity11640 did not affect 24-h retention. @entity3826 enhanced memory in @entity35 given pretraining raclopride, suggesting that the effect was mediated by selective activation of D1 receptors. The results indicate that activation of D1 receptors can enhance recognition memory consolidation. Importantly, pharmacological activation of D1 receptors enhanced novel object recognition memory even under conditions in which control @entity35 showed significant retention.
