Tracheal intubating conditions using XXXX and @entity1937 target-controlled infusions.

@entity1 @entity1875 @entity1937
Using target-controlled infusions (TCI) we aimed to determine the most appropriate dose of @entity1937 required for intubation, using a steady effect-site concentration of @entity1875 and without the use of neuromuscular blocking drugs. Sixty ASA III @entity1 presenting for elective surgery were randomly allocated to one of three groups. Anaesthesia was induced in all @entity1 using a target-controlled infusion of @entity1875 6.5 microg x ml(-1). This was reduced to 3 microg x ml(-1) after 1 min. Each group received a different TCI of @entity1937 , 19, 15 or 11 ng x ml(-1), which was reduced to 10, 8 or 6 ng x ml(-1), respectively, after 1 min. Laryngoscopy and intubation were attempted at 4 min. Laryngoscopy and ease of intubation were assessed using a standard scoring system. Intubation was considered satisfactory in 75% of @entity1 in groups 1 and 2 and 35% of @entity1 in group 3. Intubation was successful in 20/20, 19/20 and 15/20 @entity1 in groups 1, 2 and 3, respectively. Pulse oximetry, heart rate and noninvasive arterial pressure were measured pre-induction, and at intervals until after laryngoscopy and intubation. Mean arterial pressure (MAP) and heart rate decreased following induction of anaesthesia in all groups, which was statistically significant. Following laryngoscopy, MAP and heart rate increased, but were significantly less than the corresponding baseline values.
