Clinicopathological XXXX and early @entity5 treatment.

@entity1 @entity5 @entity1066 @entity957 @entity3
OBJECTIVE: To analyze clinicopathological @entity5 and to calculate survival rates (SR) with disease free survival rates (DFSR) and recurrence rates (RR) in different treatment modalities and to compare the results of surgery alone and radiotherapy alone in stage I and stage II disease and to calculate better option of treatment in @entity5 . DESIGN: A longitudinal study. PLACE AND DURATION OF STUDY: Department of Otolaryngology and Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad (PIMS) from January 1987 to June 1998. @entity1 AND METHODS: Case histories of 67 @entity1 were collected from departmental record. Clinical data included age at diagnosis, gender of @entity1 , location of @entity5 , presenting symptoms and their duration, biopsy report, predominant histological pattern of @entity5 , nodal status, stage of @entity5 , treatment modality employed, @entity5 recurrence, @entity3 and survival rates with disease-free survival rates after 2 year s follow-up. RESULTS: Among 67 @entity1 there were 31 males and 36 females. Mean age was 50 years (range 20 to 80 years). Sixtyseven @entity1 with primary @entity5 constituted 38.8% of oral @entity5 during period of 1987 to 1998 in PIMS. Smoking, poor orodental hygiene (PODH) and betel nuts chewing were the main risk factors. Odynophagia and painful @entity1066 on lateral border of tongue were the main clinical symptoms with average duration of 7 months. Regional lymph nodes were palpable in 32.8%, 5.5% was in stage I, 35.8% in stage II, 29.8% in stage III, and 28.3% was in stage IV. No @entity1 was found to have distant @entity3 . Histopathology in 94% of cases was @entity957 ( @entity957 ). Recurrence and survival rates were determined in 49 @entity1 . Average time of recurrence was 12.5 months. Recurrence was 100% loco regional (LR). It was 85.7% in @entity1 treated with radiotherapy (RT) alone, 42.1% in @entity1 treated with surgery alone and 31.2% in @entity1 treated with combination of surgery and radiotherapy (RT). Two years survival was 64.2%, 84.2%, 93.7% and 2 years disease-free survival was 14.2%, 57.8% and 68.7% in @entity1 treated with radiotherapy, surgery and combination of radiotherapy (RT) and surgery respectively. CONCLUSION: In early stages of @entity957 could be used but surgery is better option to decrease the recurrence and to improve the quality of life. In late stages combination of surgery and RT is better than single modality treatment.
