Prognostic Value of @entity26 Kinetics During Recovery From Cardiopulmonary Exercise Testing in @entity1 with XXXX .

@entity1 @entity712 @entity4962 @entity7774 @entity26 @entity544 @entity24716 @entity204
BACKGROUND: Peak @entity26 uptake (V  O2peak) is a well-established prognostic marker in @entity712 ( @entity712 ). Cardiopulmonary exercise testing (CPET) provides physiological parameters other than V  O2peak that might have prognostic value. We aimed at determining whether exercise recovery data kinetics have prognostic implications over V  O2peak and @entity712 Survival Score. METHODS: Exercise data from 200 consecutive @entity712 @entity1 evaluated for possible heart transplantation and received CPET at our institution between 2004 and 2011 were analyzed. The rate of recovery of @entity26 uptake ( @entity4962 ) at 2 minutes after exercise ( @entity4962 - @entity24716 ) was calculated using the difference between V  O2peak and @entity4962 at minute 2 of recovery and expressed as a percentage of V  O2peak. The composite primary end point was the time from CPET to the first event including death, heart transplant, or mechanical heart implantation. RESULTS: Mean follow-up period was 1271    61 days during which there were 108 first events including 35 @entity204 , 66 heart transplants, and 7 mechanical heart implantations. The strongest prognostic factors in the univariate analysis were @entity4962 - @entity24716 , V  O2peak, @entity4962 efficiency slope, and ventilation to @entity544 excretion ratio slope (all P < 0.0001). Multivariate analysis showed that @entity4962 - @entity24716 (P < 0.0001), ventilation to @entity544 excretion ratio slope (P  = 0.0022), use of @entity7774 -converting enzyme inhibitors or angiotensin receptor blockers (P  = 0.0042), presence of a defibrillator (P  = 0.0127), and mean arterial pressure (P  = 0.0151) were independent predictors of event-free survival time. CONCLUSIONS: @entity4962 - @entity24716 was the strongest prognostic marker of death, heart transplantation, and mechanical heart implantation in severe @entity712 . This finding should be confirmed prospectively.
