Basic pharmacodynamics of antibacterials with clinical applications to the use of XXXX , glycopeptides, and linezolid.

@entity2176 @entity115 @entity3405 @entity7660 @entity798 @entity11248 @entity1729 @entity5136
Time above MIC for free drug concentrations is the important PK-PD parameter correlating with the efficacy of @entity3405 antibiotics. The duration of time plasma concentrations needed to exceed the MIC is relatively similar for most organisms except staphylococci. Neutrophils contribute very little to the overall activity of @entity7660 . The appearance of increasing antimicrobial resistance can challenge the efficacy of these drugs when concentrations do not exceed the MIC for 40% to 50% of the dosing interval. Time above MIC with oral @entity115 and @entity115 - @entity798 can be enhanced with high-dose formulations. Time above MIC with parenteral preparations can be enhanced by longer intravenous infusions or even continuous infusion. The 24-hour AUC-MIC is probably the important PK-PD parameter correlating with the efficacy of @entity2176 and @entity11248 . It clearly is the important parameter for the efficacy of @entity5136 . Usual doses of these drugs generally provide adequate plasma concentrations to treat effectively infections in which plasma concentrations are predictive of tissue concentrations. Penetration of these drugs into respiratory secretions, such as ELF, is enhanced for linezolid and reduced for @entity2176 . This may give linezolid an advantage over @entity2176 in certain @entity1729 .
