Re-irradiation of locally recurrent XXXX with fast neutrons.

@entity1 @entity957 @entity5
Forty-six @entity1 with locally recurrent disease were re-irradiated with fast neutrons at Fermilab. All had received prior radical radiation therapy either with or without surgery. Six were palliative. Forty @entity1 treated with curative intent were analyzed for local response, survival, and complications. The overall response rate was 78% (31/40); 50% (20/40) had a complete local response. Ten of 16 @entity1 (63%) with @entity957 in the head and neck regions had complete response, whereas only nine of twenty @entity1 (45%) with @entity957 were complete responders. In a subset of 12 @entity1 with @entity5 , 10 had a complete response (83%). Two of these 10 @entity1 are alive beyond 5 years. Observed median survival for the forty @entity1 was 9.3 months, and for complete responders 14.4 months. Observed median survival for partial responders was only 7.5 months. Four of six @entity1 treated for palliation had significant subjective improvement. Significant morbidity, Grade III or greater (EORTC/RTOG scale), was seen in only 10 @entity1 (25%), and this was found to depend directly on the total dose delivered. We conclude that neutron beam therapy can be used as a therapeutic modality for @entity1 with recurrent @entity5 with an acceptable degree of morbidity.
