Resting activity in visual and corticostriatal pathways in XXXX with @entity1833 .

@entity1 @entity227 @entity191 @entity1833 @entity4365
BACKGROUND: @entity1833 are an important non-motor complication of @entity191 ( @entity191 ) and carry a negative prognosis. Their biological basis is uncertain, but may relate to the activity of resting state networks in brain. We therefore aimed to investigate functional activity of brain in @entity1 with @entity1833 (PDVH) in resting state compared to @entity1 without @entity1833 (PDnonVH) and a healthy control group (HC). METHODS: Resting state functional MRI was acquired and the primary analysis compared the @entity4365 ( @entity4365 ) across groups. This informed a secondary analysis, in the @entity191 groups only, comparing functional connectivity between a 'seed' region in the occipital lobe and the rest of the brain. RESULTS: Individuals with PDVH showed lower @entity4365 in bilateral lingual gyrus and cuneus and greater @entity4365 in temporo-parietal regions, medial temporal gyrus and cerebellum than PDnonVH and HC. PDnonVH also had lower @entity4365 in occipitoparietal region and greater @entity4365 in medial temporal gyrus, temporo-parietal and cerebellum regions than HC. Functional connectivity analysis revealed that, although both @entity191 groups had lower occipital functional connectivity relative to the HC group, occipital - corticostriatal connectivity was significantly higher in those with PDVH compared with PDnonVH. CONCLUSION: Our study reveals widespread hemodynamic alterations in @entity191 . However, within a functionally abnormal occipital lobe, those with PDVH have even lower @entity4365 than non-hallucinators, but have higher occipital functional connectivity with cortical-striatal regions. These findings suggest disruption of pathways underpinning both primary @entity227 may contribute to @entity1833 in @entity191 .
