Group B streptococci elicit leukotriene B4 and XXXX from @entity1 monocytes: neonates exhibit a diminished response.

@entity1 @entity1892 @entity687
Neonatal monocytes have diminished function compared with adult cells. The ability to recruit neutrophils through elaboration of chemoattractants has not been evaluated in @entity1 . The pattern of chemoattractant release induced by @entity1892 ( @entity1892 ) also is unknown. Adult and cord blood monocytes were stimulated with @entity1892 . Supernatants were used as the attractant in blind well chambers; migration to neonatal supernatants was diminished. @entity687 ( @entity687 ) and leukotriene B4 (LTB4) were released in greater quantities by adult monocytes in response to either @entity1892 or lipopolysaccharide. Opsonization of @entity1892 was not required for @entity687 release. Adult monocytes released more LTB4 when stimulated with unopsonized @entity1892 than with opsonized @entity1892 ; the neonate's LTB4 production did not increase. @entity687 and LTB4 accounted for the majority of chemoattractant activity released in response to @entity1892 . Decreased production of LTB4 and @entity687 may contribute to the neonate's poor host response to @entity1892 .
