DNA linkage studies of XXXX .

@entity1 @entity20034 @entity66 @entity15439 @entity1105 @entity6391 @entity1555 @entity74 @entity989 @entity995
DNA linkage studies of @entity1 @entity74 have led to rapid characterization of a number of otherwise intractable disease loci. Detection of a linked DNA marker, the first step in "reverse genetics", has permitted cloning of the genes for @entity1555 , @entity995 and chronic @entity66 , among others. Thus, the case for applying these techniques to @entity6391 and @entity66 , and the urgency in capitalizing on molecular developments, is justified and compelling. The first major success regarding @entity6391 was in demonstrating linkage of the DNA marker DXS7 (L1.28) to XRP. For autosomal forms of the disease, conventional linkage studies have provided tentative evidence for linkage of @entity20034 to the Rh blood group on chromosome lp and for linkage of @entity15439 to Gc and 4q. These provisional assignments are, at least, an important starting point for DNA analysis. The Support Program for DNA Linkage Studies of @entity989 was established to provide access for the scientific community to appropriate families, using the resources of the @entity1 Genetic Mutant Cell Repository to prepare, store and distribute lymphoblast lines. To date, two extensive, well-characterized families are included in the program: the autosomal dominant @entity6391 family UCLA-RP01, and the @entity15439 families LSU-US01. It is highly likely that rapid progress will be made in mapping and characterizing the @entity1105 . We believe the support program will facilitate this progress.
