High Dietary Fat Intake during Lactation Promotes the Development of Social Stress-Induced @entity28 in the Offspring of XXXX .

@entity844 @entity28 @entity19 @entity1184 @entity2819 @entity1386
UNASSIGNED: This study examined how a maternal @entity1386 ( @entity1386 ) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of @entity28 . C57BL/6J @entity19 were fed a commercial diet (CD) during pregnancy and a CD or @entity1386 during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or @entity1386 until 11 weeks of age. Offspring were housed alone (isolation stress) or at six per cage (ordinary circumstances). Thus, offspring were assigned to one of eight groups: dams fed a CD or @entity1386 during lactation and offspring fed a CD or @entity1386 and housed under ordinary circumstances or isolation stress. Serum @entity2819 level was significantly elevated by isolation stress. High-fat feeding of offspring reduced their serum @entity2819 level, which was significantly elevated by a maternal @entity1386 . A maternal @entity1386 and isolation stress had combined effects in elevating the serum @entity2819 level. These findings suggest that a maternal @entity1386 during lactation enhances the stress sensitivity of offspring. White adipose tissue weights were significantly increased by a maternal @entity1386 and isolation stress and by their combination. In addition, significant adipocyte @entity1184 was induced by a maternal @entity1386 and isolation stress and exacerbated by their combination. Thus, a maternal @entity1386 and isolation stress promote visceral fat accumulation and adipocyte @entity1184 , accelerating the progression of @entity28 through their combined effects. The mechanism may involve enhanced @entity844 synthesis and lipid influx from blood into adipose tissue. These findings demonstrate that a maternal @entity1386 during lactation may increase the susceptibility of offspring to the development of stress-induced @entity28 .
