Relation of latex-specific IgE titer and symptoms in XXXX allergic to latex.

@entity1 @entity7370 @entity566 @entity565 @entity5526 @entity110
BACKGROUND: The relation between latex-specific IgE titer and the type or total number of latex-induced symptoms has not been previously investigated. OBJECTIVE: We sought to determine the association of latex-IgE in vitro assay results with the type, number, or severity of symptoms in @entity1 allergic to latex. METHODS: Ninety-one @entity1 with positive histories and positive skin test responses were identified as having type I @entity566 . Data was collected for reported symptoms after latex exposure. Symptom severity was quantitated by 2 scores: (1) the total number of symptoms to latex exposure and (2) a symptom severity score (3 = anaphylaxis, 2 = @entity565 , and 1 = @entity7370 , @entity110 , or both). All subjects underwent AlaSTAT and CAP tests. RESULTS: AlaSTAT class was associated with total number of symptoms (r = 0.32, P <.001) and severity score (r = 0.33, P <.002). Similarly, CAP class was associated with both number of symptoms (r = 0.32, P <. 0001) and severity score (r = 0.31, P <.001). Among the symptoms reported, @entity565 had the strongest association with a positive in vitro IgE assay (odds ratio = 6.7 [95% confidence interval = 1.9, 25. 6]), followed by @entity110 (odds ratio = 1.9 [95% confidence interval = 0.8, 4.6]). @entity5526 had no statistical association with in vitro assays in this study. AlaSTAT and CAP class correlated together significantly (r = 0.58, P <.001). CONCLUSION: @entity1 allergic to latex with higher AlaSTAT or CAP class were more symptomatic. Increasing class or titer also predicted more severe symptoms. Higher class of either the AlaSTAT or CAP assay to latex was strongly associated with latex-related @entity565 and @entity110 and marginally associated with latex-related @entity7370 .
