Comparative effects of four XXXX synthesis inhibitors on the obstructed kidney in the @entity235 .

@entity8 @entity235 @entity1695 @entity4358 @entity5018 @entity3009 @entity5274
Comparative effects of four @entity3009 synthesis inhibitors (PGSI) on the acutely obstructed kidney were studied using an intact @entity235 model. Trigonal vesicostomies were @entity5274 were @entity8 . After recovery, experiments were run at weekly intervals with one drug administered each week in a random fashion. @entity1695 was obtained using a Fogarty balloon catheter passed retrogradely into the distal ureter and inflated. When renal pelvic pressure reached 80 cm./ @entity4358 the designated PGSI was given and a repeat dose was given 30 minutes later. Mean blood pressure was also monitored during several experiments. With the first dose significant decreases in renal pelvic pressure were obtained with all drugs tested. Only @entity5018 showed a significant further decrease with the second dose. @entity5018 showed the greatest decrease in pressure with the first dose, which was significantly greater than the other drugs tested. There was no association between mean blood pressure changes and the nadir of renal pelvic pressure.
