Effects of XXXX on @entity5 susceptibility.

@entity137 @entity19 @entity5 @entity843 @entity409 @entity665 @entity1233 @entity1232 @entity320
@entity1232 ( @entity1233 ) exposure altered the activity of the macrophage and natural killer (NK) cell defense mechanisms against the B16F10 @entity320 in B6C3F1 adult female @entity19 as assessed by several immunologic assays. Following 14 daily exposures (i.p.) to 1.5, 3.0, or 5.0 mg @entity1233 /kg, @entity19 were injected (i.v.) with B16F10 @entity320 . The incidence and number of lung nodules, determined 18 days after challenge, were decreased in the @entity1233 -exposed animals. The initial observation indicated the @entity19 exposed to 3 mg/kg @entity1233 were afforded the greatest protection. However, when @entity19 exposed to the highest dose of @entity1233 were divided into subgroups of @entity19 with or without @entity843 , there was a degree protection seen in the 5-mg/kg-treated @entity19 without @entity843 that was comparable to that of the 3-mg/kg group. The development of @entity843 is an overt toxic effect reflecting @entity409 and was frequently associated with exposure to 5 mg/kg @entity1233 . Exposure to @entity1233 produced only slight changes in the activity of splenic NK cells as determined by the @entity137 of 51Cr-labelled YAC-1 cells. The activity was significantly increased only in @entity19 exposed to 3 mg/kg @entity1233 and only at effector:target (E:T) ratios of 30:1 and 10:1. Interestingly, the activity of the NK cells was significantly decreased at all E:T ratios in @entity19 exposed to 5 mg/kg that developed @entity843 . The number of peritoneal exudate cells was decreased, albeit nonsignificantly, in a dose-related fashion. The phagocytic activity, as measured by the uptake of fluorescent latex beads, was increased in a dose-related fashion with significance noted at the highest dose of @entity1233 . The role of the macrophage in the increased resistance to the @entity5 challenge was assessed with bone marrow derived macrophages. The cytostatic activity versus @entity19 @entity5 cells, as measured by the uptake of @entity665 , was markedly increased in the bone marrow derived macrophages from @entity1233 (5mg/kg) @entity19 when compared to vehicle controls. These results suggest that exposure to @entity1233 alters bone marrow, particularly the differentiation of effector tumoricidal cells, which renders the host more resistant to metastatic @entity5 formation.
