XXXX : do HRCT criteria established by ATS/ERS/JRS/ALAT in 2011 predict disease progression and prognosis?

@entity1 @entity2416 @entity4595 @entity16058
PURPOSE: The objective of the study was to determine whether HRCT criteria for @entity2416 ( @entity2416 ), possible @entity2416 or no- @entity2416 pattern recommended by ATS/ERS/JRS/ALAT guidelines 2011 are able to predict progression and prognosis of the disease in a group of @entity1 with fibrotic @entity16058 ( @entity16058 ). MATERIALS AND METHODS: This was a retrospective study conducted with the approval of the ethics committee. Two radiologists at baseline HRCT distributed 70 @entity1 with fibrotic @entity16058 into three groups on the basis of the 2011 guidelines: @entity2416 pattern (group 1), possible @entity2416 pattern (group 2), inconsistent with @entity2416 pattern (group 3). The different abnormalities (honeycombing, reticulation, ground-glass and traction @entity4595 ), fibrotic score (reticulation  +  honeycombing) and overall CT score were visually scored at baseline and during the follow-up (total HRCT 178). The mortality rate of the three groups was compared. The baseline abnormalities were then correlated with the mortality rate in the @entity2416 group. RESULTS: The inter-observer agreement in the classification of the abnormalities in the three groups was almost perfect (k  =  0.92). After consensus, 44 @entity1 were classified into group 1, 13 into group 2 and 13 into group 3. During a mean follow-up of 1386  days, overall CT score, fibrotic score, honeycombing and traction @entity4595 showed a significant progression in group 1. The mortality rate was significantly higher in group 1 (18 deaths) versus group 2 and 3 (1 death each). In group 1, baseline honeycombing rate higher than 25  %, fibrotic score higher than 30, overall CT score greater than 45 and traction @entity4595 in more than 4 lobes defined the worst prognosis. CONCLUSION: HRCT classification based on 2011 guidelines showed high accuracy in stratifying fibrotic changes because in our study @entity2416 , possible @entity2416 and inconsistent with @entity2416 pattern seem to be correlated with different disease progression and mortality rate.
