Combined application of @entity900 , @entity7324 , hyaluronidase and radiation for treatment of advanced @entity957 of the XXXX .

@entity1 @entity135 @entity137 @entity7324 @entity957 @entity900 @entity33 @entity1544
In a prospective pilot study, 32 @entity1 with advanced inoperable @entity957 of the @entity135 were treated with polychemotherapy and hyaluronidase combined with radiation therapy. Polychemotherapy consisted of 5 mg @entity7324 on day 1 and 80 mg/m2 @entity900 on day 2. The @entity1 were given 200,000 IU hyaluronidase intravenously 20 minutes prior to @entity7324 and @entity900 . Radiation in fractions of 2 Gy per day was administered on the following days (days 3-5, 8-12, 15-18), that is, 12 times. This regimen was repeated twice starting with day 22 and 43. Side effects were mainly of local character: moderate to severe @entity33 in 10 @entity1 and mild @entity33 in 22 @entity1 . No severe systemic @entity137 was observed. Complete remission was achieved in 27 of 32 @entity1 . At present, 16 @entity1 are alive and without relapse. The average time of follow-up is 47 months (range: 26-75 months). These preliminary results suggest that combined therapy with @entity7324 , @entity900 , hyaluronidase, and radiation are well tolerated by most @entity1 and highly effective against advanced @entity1544 and the neck.
