Expression of tissue inhibitors of metalloproteinases (TIMPs) in XXXX .

@entity1 @entity1552 @entity5 @entity406 @entity2843 @entity982 @entity3 @entity356
Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in @entity5 invasion and @entity3 , being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). Sixty-five @entity1 who underwent surgery for @entity356 in 1992 at Chonnam National University Hospital were selected for this study. The primary selection criteria were the availability of @entity406 -fixed and @entity982 -embedded blocks and sufficient clinical follow-up for @entity5 -specific survival analysis. In this study, we examined the expression of @entity2843 and @entity1552 in @entity1 @entity356 tissue by in situ hybridization and immunohistochemistry, and the correlation between their expression and clinicopathological parameters. @entity2843 and @entity1552 expressions were detected predominantly in the peritumor stromal cells rather than @entity5 cells themselves. Immunohistochemical stainings were concordant with the result obtained by in situ hybridization. The intensity of @entity2843 immunohistochemical stromal staining correlated with @entity5 stage (P = 0.009) and @entity1 survival (P = 0.025). However, the intensity of @entity1552 immunohistochemical stromal staining did not correlate with @entity5 stage (P = 0.339) and @entity1 survival (P = 0.474). The correlation between the increased @entity2843 expression and @entity5 stage noted in this study reflects a role of @entity2843 in predicting the @entity356 . @entity1552 expression did not correlate with clinicopathological parameters. However, expression of @entity2843 and the possible additional value of @entity1552 should be further explored in determining the prognosis of @entity356 .
