Involvement of CD56brightCD11c+ cells in XXXX -mediated expansion of human y   T cells.

@entity5921 @entity137 @entity2937 @entity2940 @entity5750 @entity5 @entity7938 @entity8730 @entity310 @entity2935 @entity3646 @entity281 @entity8923 @entity1453 @entity1454 @entity379 @entity2902 @entity1199 @entity4381 @entity2841
y   T cells are considered to be innate lymphocytes that play an important role in host defense against @entity5 and @entity281 . We recently reported that @entity8923 markedly amplified y   T cell responses to @entity4381 ( @entity5921 )/ @entity1199 . In an extension of this finding, we analyzed the mechanism underlying the @entity8923 -mediated expansion of y   T cells. After incubation of PBMCs with ZOL/ @entity1199 / @entity8923 , the majority of the cells expressed y   TCR, and the rest mostly exhibited @entity2940 (bright) @entity2935 (+) under the conditions used in this study. @entity2940 (bright) @entity2935 (+) cells were derived from a culture of @entity2940 (int) @entity2935 (+) cells and @entity5750 (+) cells in the presence of @entity1199 and @entity8923 without the addition of ZOL. They expressed IL-18Rs, HLA-DR, @entity2902 , @entity7938 , @entity8730 , @entity2937 , and @entity1453 / @entity1454 . In addition, they produced @entity379 , @entity310 , but not IL-12, when treated with @entity1199 / @entity8923 , and they exerted @entity137 against K562 cells, thus exhibiting characteristics of both NK cells and dendritic cells. Incubation of purified y   T cells with @entity2940 (bright) @entity2935 (+) cells in the presence of ZOL/ @entity1199 / @entity8923 resulted in the formation of massive cell clusters and led to the marked expansion of y   T cells. However, both conventional @entity2940 (-/int) @entity2935 (high) dendritic cells induced by @entity2841 / @entity3646 and @entity2940 (+) @entity2935 (-) NK cells failed to support the expansion of y   T cells. These results strongly suggest that @entity2940 (bright) @entity2935 (+) cells play a key role in the @entity8923 -mediated proliferation of y   T cells.
