Correlation between local vascular and sensory changes following tissue @entity32 induced by repetitive application of topical XXXX .

@entity32 @entity1931 @entity158 @entity2951
The aim of the present study was to investigate local vascular and sensory changes and their correlation in order to obtain a better understanding of the mechanisms of @entity1931 , @entity1931 and vascular changes following tissue @entity32 induced by repetitive application of @entity2951 cream. This type of application was utilized as a controlled model of @entity32 which was altered in intensity due to its repetitive applicability. Ten healthy volunteers participated in two experiments separated by at least five days. Each experiment consisted of a baseline session followed by five additional sessions. Before these sessions either 1.5 g @entity2951 (1%) or placebo cream was applied to the volar site of the forearm for 15 min. The areas of stroking @entity1931 and pin-prick @entity1931 were mapped and the intensity of spontaneous @entity158 (VAS) was assessed after each application of the cream. In addition, the visible flare, temperature (IR-Thermography), and blood- flow (Laser-Doppler) were measured. The first application of @entity2951 was perceived as painful; it induced both @entity1931 and @entity1931 . Compared to placebo, the first application of @entity2951 cream also resulted in an increased blood-flow, elevated temperature and visible flare. The highest values of these sensory and vascular parameters were reached after the third application. A direct correlation between visible flare, secondary @entity1931 and @entity1931 following repetitive application of @entity2951 indicates that both common central and peripheral mechanisms were involved in these changes.
