Familial chronic B-cell malignancy. XXXX in mother and daughter.

@entity1 @entity1619 @entity1579 @entity1778 @entity1800 @entity1199
Two familial cases of @entity1619 are reported: a daughter, 44-years-old, with a very unusual ultrastructural pattern found in hairy cells, the "tubuloreticular inclusions", and her mother, 71-years-old, who was affected six years later. Routine laboratory investigations, cytochemical and cytogenetic studies including HLA typing, as well as in vitro proliferative response of peripheral blood mononuclear cells (PBMC) to polyclonal mitogens and to exogenous @entity1199 , were performed. The immunological characterization by assessing the cell surface phenotypic markers with monoclonal antibodies and @entity1579 ( @entity1579 ) investigations were also carried out. In case 2 all tests were performed both on PBMC and on the bone marrow cells. To the best of our knowledge this is one of the first reports of such familial association. The possibility that genetic factors might play a role in the etiology of @entity1778 in @entity1 is discussed: in our two cases, however, cytogenetic studies did not support this, while HLA typing revealed a non-significant association of HCL with DQw3 allele. Alternatively, an environmental factor has been considered, and a @entity1800 -perhaps by a retrovirus of the HTLV family has been suggested as tubuloreticular inclusions have been found in both @entity1619 , as reported, by us, and AIDS-LAS. However, a long time elapsed between the manifestation of HCL in the daughter and in the mother, and as the two @entity1 had not been living together at that time, the possibility of a viral transmission seems minimal. The results of @entity1579 and of immunological investigations are presented and discussed. Both, but particularly the latter, support the B cell nature of the hairy cell.
