Relation between heavy and binge drinking and all-cause and XXXX in Novosibirsk, Russia: a prospective cohort study.

@entity1 @entity301 @entity285 @entity204 @entity65
BACKGROUND: Moderate @entity285 consumption is associated with reduced @entity65 , but binge drinking is thought to be detrimental. We examined effects of heavy and binge drinking in a population with high rates of binge drinking. METHODS: We did a prospective cohort study in Novosibirsk, Russia, in 6502 @entity1 aged 25-64 years at baseline who were examined in WHO MONICA (monitoring trends and determinants in @entity65 surveys) in 1985/86, 1988/89, and 1994/95, and in a pilot study in 1984. We assessed @entity285 intake and drinking pattern by questionnaire; binge drinking was defined as consumption of 160 g or greater of pure @entity285 on a typical occasion. @entity1 were followed-up for a median of 9.5 years (range 3.1-15.2). FINDINGS: There were 836 @entity204 in the cohort, 395 of which resulted from @entity65 . Prevalence of binge drinking at baseline was 16% (n=1005). Adjusted relative risks for binge drinking at least once a month (compared with consumption of <80 g pure @entity285 ) were 1.05 (95% CI 0.80-1.36) for @entity204 from all causes, 0.99 (0.66-1.50) for @entity204 from @entity65 , 1.27 (0.81-1.99) for @entity204 from @entity301 , and 2.08 (1.08-3.99) for @entity204 from external causes. Risk of total and @entity65 was raised in a small group of frequent heavy drinkers (5% [264] of all drinkers); for this group, adjusted relative risks were 1.61 (1.04-2.50) for total mortality and 2.05 (1.09-3.86) for @entity204 from @entity65 . INTERPRETATION: The risk of @entity204 from @entity65 seems to be increased in frequent heavy drinkers, but is not necessarily associated with episodic binge drinking.
