XXXX : effect of glandular cell type on prognosis, treatment, and survival.

@entity5 @entity957 @entity1544 @entity1962 @entity420
OBJECTIVE: To investigate survivals from cervical @entity5 , with special reference to effects of glandular histology and its influence on prognostic characteristics and management decisions. METHODS: Data on cervical @entity5 , diagnosed in 1984-2000, were obtained from the gynecologic oncology registry of hospitals of the University of Adelaide. Comparisons were made of disease-specific survival, age at diagnosis, diagnostic period, stage, grade, and primary course of treatment. RESULTS: The study included 544 @entity957 , 43 @entity1962 , @entity5 , 136 other @entity420 , and 19 @entity5 of "other" histological type. Overall survival was 72.2% at 5 years from diagnosis, decreasing to 67.5% at 15 years. Survival was lower for older ages, higher grades, and higher International Federation of Gynecology and Obstetrics stages, although equivalent for stages IIA and IIB. Unadjusted survivals varied by histological type (P =.001), with lower survivals suggested for adenosquamous and clear cell lesions and "other" histological types than for @entity957 and other @entity420 . After adjusting for age, stage, grade, and diagnostic period, @entity420 had a higher case fatality than squamous cell lesions (relative risk 2.08, 95% confidence limit 1.35, 3.21), whereas the elevation in relative risk was lower and not statistically significant for a combined adenosquamous and clear cell category at 1.25 (0.69, 2.24). For stage II, both @entity420 and the adenosquamous and clear cell group had lower survivals than @entity1544 . CONCLUSION: Relative to @entity957 , @entity420 and potentially @entity5 are becoming more common. This has implications for screening, treatment, and prognosis.
