Role of @entity10815 activation in major adverse cardiovascular events and new-onset @entity712 after XXXX .

@entity1 @entity10815 @entity712 @entity299 @entity583 @entity65
AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity10815 ( @entity10815 ) have been found in @entity1 with @entity583 ( @entity583 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity712 . This study aimed to evaluate the role of serum @entity10815 activity in the development of @entity712 in @entity1 with @entity583 ( @entity583 ). @entity1 AND METHODS: Eighty-eight consecutive @entity1 (79.5   % @entity1 , mean age 57.4        10.2  years) with @entity583 were included in this study. Serum @entity10815 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity1 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity583 , unplanned PCI, new-onset @entity712 , and @entity65 . RESULTS: Serum @entity10815 activity was significantly higher in @entity1 with @entity583 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity10815 activity in these @entity1 was inversely related to new-onset @entity299 compared with @entity1 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity1 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity10815 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity10815 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity1 with new-onset @entity299 , and lower levels of serum @entity10815 were associated with MACE at the 6-month post-MI follow-up.
