Minimal Clinically Important Difference on XXXX Sleep Scale 2nd Version.

@entity1 @entity1726 @entity303 @entity191
Background and Aims. The aim of the present study was to determine the estimates of minimal clinically important difference for @entity191 Sleep Scale 2nd version (PDSS-2) total score and dimensions. Methods. The subject population consisted of 413 @entity1726 @entity1 . At baseline, MDS-UPDRS, Hoehn-Yahr Scale, Mattis @entity303 Rating Scale, and PDSS-2 were assessed. Nine months later the PDSS-2 was reevaluated with the @entity1 -Reported Global Impression Improvement Scale. Both anchor-based techniques (within @entity1 ' score change method and sensitivity- and specificity-based method by receiver operating characteristic analysis) and distribution-based approaches (effect size calculations) were utilized to determine the magnitude of minimal clinically important difference. Results. According to our results, any improvements larger than -3.44 points or worsening larger than 2.07 points can represent clinically important changes for the @entity1 . These thresholds have the effect size of 0.21 and -0.21, respectively. Conclusions. Minimal clinically important differences are the smallest change of scores that are subjectively meaningful to @entity1 . Studies using the PDSS-2 as outcome measure should utilize the threshold of -3.44 points for detecting improvement or the threshold of 2.07 points for observing worsening.
