Effects of @entity2647 induced increase in arterial pressure and closure of the ductus arteriosus on the secretion of @entity27120 (ANP) and XXXX in the ovine fetus.

@entity17955 @entity27120 @entity742 @entity2647
Although @entity27120 (ANP) has been detected in the plasma of late gestation fetal @entity742 , stimuli that control its secretion and its function in regulating fluid volume are unclear. To determine stimuli that increase ANP secretion and to ascertain whether the response is a function of gestation we studied 20 chronically cannulated fetal @entity742 . The fetuses were divided into 3 groups; Group I (age range 118-129 days), Group II (age range 129-141 days) and Group III (age range 127-137 days) gestation. Arterial pressure was increased to within a physiologic range by infusing @entity2647 at 6 micrograms/min at 0.1 ml/min into the inferior vena cava of the fetus (Groups I and II). Corrected for body weight fetuses in Group I received 2 micrograms/kg/min whereas fetuses in Group II received 1.66 micrograms/kg/min. In the fetuses in Group III preload to the right side of the heart was increased by inflating an occluder cuff was placed around the ductus arteriosus. Systemic mean arterial pressure (MAP) increased significantly in fetuses in Groups I and II. Plasma ANP concentrations increased significantly in all fetuses. Plasma @entity17955 Activity (PRA) decreased significantly in the fetuses in Group II. These results suggest that @entity2647 infusion and closure of the ductus arteriosus in utero increase circulating ANP in fetal @entity742 .
