Expression of XXXX protein product in triple negative @entity0 and relation with clinical and histopathological parameters.

@entity1 @entity0 @entity5 @entity5345 @entity876 @entity4205 @entity5282 @entity1722
(Full text is available at http://www.manu.edu.mk/prilozi). INTRODUCTION: "Triple" negative @entity0 is a subgroup of so-called basal-like @entity0 . They are represented with 15% of all @entity0 , characterized with lack of @entity5282 as well as with negative expression of @entity1722 test. These @entity5 are more frequent in Afro-Americans and Latin-Americans, in @entity1 with @entity5345 mutations and in @entity1 with recent delivery. The aim of this study is to present the immunohistochemical and clinico-pathological characteristics of the @entity0 and their correlation with expression of the protein product of the @entity5 suppressor gene @entity876 . METHODS: A retrospective analyses of 24 @entity1 with @entity0 was performed. All of the @entity1 were evaluated in the Histopathological Laboratory of the Clinical Hospital Sistina, during the period from June 2009, until June 2011. The standard immunohistochemical procedures, including the @entity5282 status, @entity1722 status, proliferative index - Ki67 and @entity876 gene protein product were performed, as well as additional immunohistochemical staining for so-called basal keratins ( @entity4205 and high molecular weight cytokeratin 34BE12). RESULTS: The age of the @entity1 ranged from 29-77 years. Positive lymph nodes were found in 14 (59%) @entity1 . The @entity5 was poorly differentiated in 19 @entity1 (79%). Overexpression of the @entity876 protein product was evaluated in 19 (79%) of the cases. All @entity876 negative @entity1 (5/5) had poorly differentiated @entity5 (G3), associated with positive regional lymph nodes. The @entity876 positive group expressed quite opposite correlation, only 9/19 (47%) were with positive lymph nodes (p = 0.03). The expression of @entity876 protein product was also associated with the nuclear grade (p = 0.005), the mitotic index (p = 0.001), lymph-vascular invasion (p = 0.005) and with the proliferation index Ki67 (p = 0.003). There was a trend for association with the @entity5 size - pT (p = 0.05). CONCLUSION: According to the results, the triple negative @entity0 are subgroup of the poorly differentiated @entity5 frequently associated in the younger age groups. The majority of these have overexpression of the @entity876 protein product, which in other hand, are inversely correlated with lymph nodes metastases. Hence, the necessity of enriching the immunohistochemical protocol of these @entity1 with new antibodies, in order to evaluate their expression, which would be helpful for prediction the outcome of different therapeutical modalities. Key words: @entity0 , triple negative, @entity876 protein product.
