[Study of polymorphism @entity71916 of @entity8166 gene in XXXX ].

@entity1 @entity6 @entity71916 @entity8166 @entity1017 @entity41599
Objective To assess the association of the @entity71916 ( @entity41599 ) polymorphism of the gene @entity8166 in the @entity6 with the need for additional treatment and the occurrence of large newborns for the gestational age. Subjects and methods One hundred and five @entity1 recruited in Joinville - Brazil were evaluated between November 2010 and October 2012. Pregnant @entity1 were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism @entity71916 were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes. Results Thirty-five point two percent of the evaluated @entity1 carried at least one mutated allele of @entity71916 polymorphism. There were no significant differences in @entity1017 , parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of @entity1 with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%). Conclusion Our data showed that the polymorphism @entity71916 of the gene @entity8166 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population. Arq Bras Endocrinol Metab. 2014;58(9):900-5.
