Prophylactic surgery and other strategies for reducing the risk of XXXX .

@entity1 @entity43 @entity5 @entity5345 @entity2674 @entity3906 @entity5274 @entity10224
The goal of a @entity5 prevention program is to improve the mortality rates of @entity1 . No risk-reduction strategy is proven to reduce mortality rates of @entity1 at increased risk for @entity43 . Methods of @entity43 surveillance are unproven in high-risk @entity1 . According to some studies, the use of oral contraceptives in high-risk @entity1 reduces @entity43 risk. Prophylactic salpingo-oophorectomy is the most effective method of @entity5 risk reduction in @entity1 at high risk for @entity43 . However, @entity1 who undergo prophylactic salpingo-oophorectomy remain at risk for primary @entity3906 . A minority of @entity1 with @entity5345 and @entity2674 mutations are diagnosed with @entity5 at the time of surgical prophylaxis. Surgical prophylaxis should include complete @entity5274 and ovaries, procurement of peritoneal cytology, and thorough evaluation of the tubes and ovaries by an expert pathologist. Beginning at age 30 years, @entity1 with @entity5345 and @entity2674 germline mutations should have an annual or semiannual screening, consisting of serum @entity10224 measurement and transvaginal ultrasound, until the completion of childbearing. After the completion of childbearing and by age 40 years, @entity1 should undergo prophylactic salpingo-oophorectomy.
