Increased familial risk for @entity2 among relatives of XXXX @entity1 .

@entity1 @entity825 @entity1423 @entity5 @entity2
Reports of two or more anatomically distinct @entity5 types clustering in families suggest the possible existence of a susceptibility-to- @entity5 gene. To determine whether a genetic predisposition accounts for such @entity1423 , a retrospective case-control study was conducted in 1976-1979 of 337 southern Louisiana families in each of which a @entity2 @entity1 was used as the proband. A comparison of first-degree relatives of proband families with spouse (control) families revealed a significantly greater overall risk of @entity5 (odds ratio (OR) = 2.0, p less than 0.0001) in the proband group. Using logistic regression techniques to control for the confounding effects of age, sex, cigarette smoking, and occupational/industrial exposures, relatives of @entity2 probands maintained an increased risk of @entity2 (p less than 0.05). The crude odds ratio of a proband family having one family member with @entity5 was 1.67 compared with control families. Proband families were 2.16 times more likely to have two other family members with @entity5 . For three @entity5 and four or more @entity5 , the risk increased to 3.66 and 5.04, respectively. Each risk estimate was significant at the 0.01 level. The most striking differences in @entity5 prevalence between proband and control families were noted for @entity5 /sinus, mid-ear, and larynx (OR = 4.6); @entity825 , bronchus and lung (OR = 3.0); skin (OR = 2.8); and uterus, placenta, ovary, and other female organs (OR = 2.1). These data support the hypothesis of a genetic susceptibility to @entity5 in families with @entity2 .
