Predictors and patterns of recurrence after curative liver resection in XXXX , for application of postoperative radiotherapy: a retrospective study.

@entity1 @entity5 @entity1161 @entity1419 @entity3
BACKGROUND: The majority of @entity1 with @entity1419 ( @entity1419 ) who undergo complete @entity5 resection subsequently develop @entity5 recurrence. The objectives of this study were to determine the risk factors for @entity1419 recurrence after curative (R0) liver resection and to identify the feasibility about postoperative adjuvant @entity1161 ( @entity1161 ). METHODS: We retrospectively reviewed @entity1 who underwent liver resection for @entity1419 between April 1995 and December 2012 at Samsung Medical Center. Cox regression analysis was performed to determine risk factors of recurrence. @entity1 with a recurrence in remnant liver within 2  cm from the resection margin, with or without locoregional lymph node (LN) @entity3 , were considered as potential @entity1161 candidates. Center-of-mass (COM) distances between the recurrent @entity5 and the cut surface were measured with MATLAB. RESULTS: We included 153 out of 198 @entity1 who underwent partial liver resection for @entity1419 . About two thirds (n   =   93, 60.8  %) of @entity1 developed recurrent disease. The median recurrence-free survival (RFS) was 14  months (range, 0-204). @entity5 size >= 4.0  cm, LN @entity3 and @entity5 were significant predictors of @entity1419 recurrence on multivariate analysis. @entity5 size >= 5.0  cm was the only factor associated with recurrence beyond the @entity1161 field in @entity1 with recurrence. Among 93 @entity1 with recurrence, 16 (17.2  %) @entity1 were recurred in the @entity1161 field. CONCLUSION: After curative resection in @entity1419 , more than 60  % of @entity1 recurred, and among recurred @entity1 , 17.2  % were recurred within the @entity1161 field. Consequently, for control of locoregional recurrence, adjuvant @entity1161 could be carefully considered in @entity1 with recurrence factors. Especially, @entity1 with a @entity5 size larger than 5  cm should be judiciously selected for adjuvant @entity1161 .
