Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AbPPswe/ @entity20933 /\E9 XXXX .

@entity15370 @entity20933 @entity527 @entity137 @entity19 @entity3986 @entity17234 @entity1877 @entity195 @entity19447
Amyloid-b (Ab) plaques occur in @entity527 within the neocortex and hippocampus in @entity195 ( @entity195 ). Despite this observation, the effect of Ab deposition upon cholinergic and galaninergic @entity3986 formation remains unclear. Therefore, the purpose of this study was to evaluate the interaction between Ab deposition within the neocortex and hippocampus upon cholinergic and galaninergic @entity3986 formation. Neocortical and hippocampal tissue harvested from 3- and 12-month-old amyloid-b protein precursor ( @entity15370 )swe/ @entity20933 /\E9 transgenic (Tg) @entity19 were dual-immunolabeled with antibodies against either @entity1877 acetyltransferace and Ab (10D5) or @entity17234 ( @entity19447 ) and Ab. Stereology was used to quantify @entity527 . Plaque number was assessed using the optical fractionator; plaque area was calculated with the Cavalieri estimator, and @entity3986 and thickness were manually measured. Neither amyloid nor dystrophic neuritic profiles were seen in the brains of 3-month-old Tg @entity19 . In contrast, quantitative analysis revealed significantly more plaques in neocortex than hippocampus, with no difference in regional plaque size in 12-month-old Tg @entity19 . Significantly more @entity527 occurred in the neocortex and hippocampus. Additionally, cholinergic @entity3986 were @entity3986 in both regions. These data suggest that @entity527 has a greater impact upon cholinergic than galaninergic @entity3986 formation in the neocortex and hippocampus in AbPPswe/ @entity20933 /\E9 Tg @entity19 . These data are also compatible with the hypothesis that @entity17234 is neuroprotective and reduces @entity3986 formation in the face of @entity137 .
