The effect of pH versus base deficit on organ failure in @entity130 XXXX .

@entity1 @entity51 @entity130
BACKGROUND: @entity51 ( @entity51 ) calculations are affected by @entity130 -related changes in circulating concentrations of anions after injury. In contrast, pH is a direct measurement that corresponds to hypoperfusion. We hypothesized that changes in pH would more closely correspond to organ dysfunction compared with changes in @entity51 . MATERIALS AND METHODS: @entity51 and pH values were collected for the first 48  h after injury from a retrospective cohort of 74 multiply injured adult @entity1 who were admitted to the surgical intensive care unit for a minimum of 1  wk. Mean and extreme (minimum pH and maximum @entity51 ) values of pH and @entity51 were determined for day 1 (0-24  h) and for day 2 (24-48  h) after injury. Organ dysfunction was measured by averaging daily sequential organ failure assessment scores over the entire duration of intensive care unit admission. @entity51 and pH values were compared with mean modified sequential organ failure assessment scores by univariate and multivariate linear regression. RESULTS: Organ dysfunction corresponded more closely with changes in pH compared with those in @entity51 . Minimum pH and maximum @entity51 showed better correspondence to organ dysfunction compared with mean values. Minimum pH values at 24-48 h had the highest univariate (r(2)  =  0.43) correspondence to organ dysfunction. In contrast, mean @entity51 values at 24-48 h showed no correspondence (r(2)  =  0.07) to organ dysfunction. Multivariate analysis demonstrated that 24-48  h of minimum pH had the highest numerical effect on organ dysfunction. CONCLUSIONS: Correspondence between organ dysfunction and @entity51 deteriorated in contrast to increasing correspondence between organ dysfunction and pH measured within 48  h after injury.
