Radiation therapy, @entity299 , and XXXX in @entity0 @entity1 .

@entity1 @entity0 @entity63 @entity1161 @entity5 @entity299 @entity583 @entity1370
PURPOSE: The benefits of adjuvant @entity1161 ( @entity1161 ) for @entity0 may be counterbalanced by the risk of @entity1370 . We studied the cardiac effects of @entity1161 and the impact of pre-existing @entity299 ( @entity299 ) in a population-based sample of older @entity1 with @entity0 . METHODS AND MATERIALS: In the Surveillance, Epidemiology and End-Results (SEER)-Medicare database of @entity1 > or = 65 years diagnosed with Stages I to III @entity0 from January 1, 1992 to December 31, 2000, we used multivariable logistic regression to model the associations of demographic and clinical variables with postmastectomy and postlumpectomy @entity1161 . Using Cox proportional hazards regression, we then modeled the association between treatment and @entity583 ( @entity583 ) and @entity63 in the 10 or more years after diagnosis, taking the predictors of treatment into account. RESULTS: Among 48,353 @entity1 with @entity0 ; 19,897 (42%) were treated with lumpectomy and 26,534 (55%) with mastectomy; the remainder had unknown surgery type (3%). Receipt of @entity1161 was associated with later year of diagnosis, younger age, fewer comorbidities, nonrural residence, and chemotherapy. Postlumpectomy @entity1161 was also associated with white ethnicity and no prior history of @entity299 ( @entity299 ). The @entity1161 did not increase the risk of @entity583 . Presence of @entity583 was associated with age, African American ethnicity, advanced stage, nonrural residence, more than one comorbid condition, a hormone receptor-negative @entity5 , @entity299 and @entity299 . Among @entity1 who received @entity1161 , @entity5 laterality was not associated with @entity583 outcome. The effect of @entity1161 on the heart was not influenced by @entity299 or @entity299 . CONCLUSION: It appears unlikely that @entity1161 would increase the risk of @entity583 in elderly @entity1 with @entity0 , regardless of type of surgery, @entity5 laterality, or history of @entity299 or @entity299 , for at least 10 years.
