Comparative histopathologic analysis of cutaneous extranodal natural killer/ XXXX according to their clinical morphology.

@entity5 @entity75 @entity4 @entity784 @entity2688 @entity4125 @entity733 @entity272 @entity3139
BACKGROUND: Few studies have evaluated the histopathologic features of cutaneous extranodal natural killer (NK)/ @entity784 (ENKTL), and the histopathologic spectrum of this disease according to its clinical morphology remains unclear. OBJECTIVE: This study investigated the differences in pathologic findings of cutaneous ENKTL depending on clinical morphology. METHODS: A total of 41 cases of cutaneous ENKTL were included. @entity272 were classified according to clinical morphology as: (i) nodular lesions, (ii) @entity2688 or @entity733 -like swellings and (iii) erythematous to @entity4125 patches. Histopathologic variables were compared between groups. RESULTS: Perivascular infiltration of @entity5 cells and vasculopathy in the dermis and subcutaneous layer were common microscopic findings irrespective of clinical morphology. @entity4125 patches were mainly composed of small-sized @entity5 cells, whereas medium- to large- @entity5 cells were predominant in lesions of other clinical morphologies. The density of @entity5 cell infiltration was significantly higher in @entity2688 or @entity75 or nodular lesions compared with erythematous to @entity4125 patches. A @entity3139 -like pattern and angiocentricity were less common in patch lesions than in @entity2688 -like @entity4 . CONCLUSION: There is a histopathologic spectrum of cutaneous ENKTL that is dependent on the clinical morphology.
