Studies on South African cardiac glycosides. II. Observations on the clinical and haemodynamic effects of XXXX .

@entity712 @entity71904 @entity101 @entity742 @entity4785 @entity988 @entity840 @entity551 @entity3685 @entity400 @entity1277 @entity299 @entity943 @entity848
In @entity840 , the oral and subcutaneous LD50 values were very similar (cf. 0,173 mg/kg over 48 h with 0,116 mg/kg over 24 and 48 h). When dosed subcutaneously, a cumulative effect was observed. Intravenous administration of @entity71904 to anaesthetized @entity840 resulted in: dyspnoea, @entity101 , and electrocardiagraphic changes typical of @entity299 . A positive cardiac inotropic effect was succeeded by a positive chronotropic one. In @entity742 , acute and subacute intoxication resulted in ruminal, respiratory and cardiac changes. The signs included @entity3685 , @entity848 , @entity943 , @entity4785 , followed by @entity551 and progressive respiratory and @entity712 . The skeletal muscles were affected in only 1 @entity742 vide infra. In chronically intoxicated @entity742 typical clinical signs of "krimpsiekte" developed, e.g. weakness, reluctance to stand, unsteadiness on feet, @entity400 and paresis of hindquarter muscles, paresis of the neck, arching of the back and standing with the feet close together. Respiratory function was affected in all 3 cases; @entity3685 , with concomitant @entity1277 occurring in one, and a transient change in heart function in another. The syndrome induced by acute @entity71904 poisoning is similar to that of other cardiac glycosides, but the paretic signs of @entity988 resemble "krimpsiekte", a disease associated only with intoxication with the plants of the family Crassulaceae.
