Intestinal Microbiota Signatures Associated With XXXX in @entity177 .

@entity1 @entity32 @entity82 @entity1560 @entity409 @entity177 @entity6741 @entity1495 @entity3147 @entity1336 @entity99
BACKGROUND: @entity177 ( @entity177 )-associated @entity409 (IFALD) is the major cause of mortality in @entity177 . The link between intestinal microbiota and IFALD is unclear. METHODS: We compared intestinal microbiota of @entity1 with @entity177 (n = 23) with healthy controls (n = 58) using culture-independent phylogenetic microarray analysis. The microbiota was related to histological @entity99 , fecal markers of @entity32 , @entity1495 and calprotectin, and disease characteristics. RESULTS: Overabundance of Lactobacilli, Proteobacteria, and Actinobacteria was observed in @entity177 , whereas bacteria related to Clostridium clusters III, IV, and XIVa along with overall diversity and richness were reduced. @entity1 were segregated into 3 subgroups based on dominating bacteria: Clostridium cluster XIVa, Proteobacteria, and bacteria related to @entity1336 . In addition to @entity1560 and @entity82 , Proteobacteria were associated with prolonged current @entity3147 ( @entity3147 ) as well as liver and @entity32 . Lactobacilli were related to advanced @entity1560 and @entity82 mostly after weaning off @entity3147 without associated @entity32 . In multivariate permutational analysis of variance, @entity1560 , bowel length, @entity3147 calories, and antibiotic treatment best explained the microbiota variation among @entity1 with @entity177 . CONCLUSIONS: Intestinal microbiota composition was associated with @entity1560 in @entity177 and better predicted @entity1560 than duration of @entity3147 or length of the remaining intestine. Our results may be explained by a model in which @entity1560 is initiated during @entity3147 in response to proinflammatory lipopolysaccharides produced by Proteobacteria and progresses after weaning off @entity3147 , as the @entity1336 group Lactobacilli becomes dominant and affects lipid metabolism by altering @entity6741 signaling.
