The distribution of XXXX regulating enzymes in the @entity235 eye.

@entity2627 @entity235 @entity7227 @entity7669 @entity2625 @entity2041 @entity273 @entity989 @entity224 @entity10155
The retina and rod outer segments (ROS), rich in unsaturated lipids, are highly susceptible to autoxidation via free radical mechanisms. In the @entity235 eye, four enzymes, i.e.; @entity7227 ( @entity10155 ) peroxidase, @entity2041 peroxidases, @entity7669 and @entity224 dismutase which are involved in the production or degradation of @entity2627 , were measured. All enzymes were present in the retina, ciliary body and iris, but differed in concentration. @entity224 dismutase showed high activity in the ROS. In the @entity989 ( @entity989 ) a peroxidase utilizing @entity10155 as cosubstrate and @entity224 dismutase were both present. The former enzyme was found equally distributed between soluble and insoluble forms. A pigment granule fraction from the @entity989 only contained @entity10155 -peroxidase. The compartmentalization of @entity2625 regulating enzymes in the eye is striking. Whereas the retina seems well protected against @entity224 free radicals and @entity273 by virtue of @entity224 dismutase, peroxidases and @entity7669 activities, the ROS are only protected by @entity224 dismutase. Therefore, after phagocytosis of the ROS, any peroxidized lipids, organic @entity2627 , or unconverted @entity224 radicals contained within the ROS, must be detoxified by a specific @entity989 peroxidase and @entity224 dismutase. @entity273 or other peroxidized compounds apparently are not degraded by @entity2041 peroxidases or @entity7669 , since these enzymes were not measurable in our @entity989 preparations. The role of antioxidative enzymes in the eye, which retard @entity2625 and free radical information, appears to be specific and regional.
