XXXX : a retrospective analysis.

@entity3557 @entity1 @entity1496 @entity146 @entity3 @entity204
Background. Whether or not the familial form of @entity3557 is more @entity146 than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased @entity146 is more apparent in families with multiple affected members, we performed a chi square by trend analysis on our @entity1 clinical and pathologic data comparing: first degree families with three or more affected members versus first degree families with two affected members versus sporadic cases of @entity3557 . Results. No statistically significant trends were seen for any presenting surgical pathology parameter, age at presentation, length of follow-up or gender distribution. The familial groups exhibited significant trends for higher rates of reoperation (P = 0.05) and/or requiring additional radioactive @entity1496 therapy (P = 0.03), distant @entity3 (P = 0.003) and @entity204 (P = 0.01). These @entity146 features were most apparent in certain families with three or more affected members. Conclusions. Using the chi square by trend analysis, a significant trend was seen for the familial form of @entity3557 to possess more @entity146 features than the sporadic disease. Prompt recognition of the familial nature of the disease may provide earlier diagnosis and treatment in similarly affected family members.
