Association between lung capacity and abnormal XXXX metabolism: Findings from China and Australia.

@entity1 @entity230 @entity6 @entity3885 @entity209 @entity413
OBJECTIVE: Restricted pulmonary function is found among @entity1 with @entity6 . This study aimed to investigate the dose-response relationship between pulmonary function measurements (forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)) and risk of @entity209 ( @entity209 ) /type 2 @entity6 . METHODS: 1,454 adults in rural Victoria, Australia and 5,824 adults in Nanjing, China from randomly selected households provided clinical history, oral @entity413 tolerance test, lipids, anthropometric, blood pressure and spirometric measurements. @entity209 was defined by International @entity6 Federation criteria. Adjusted odds ratios for @entity209 and type 2 @entity6 with lung capacity measurements were estimated using logistic regression. Dose-response relationships were explored using restricted cubic spline models. RESULTS: There was a non-linear relationship between FEV1 and the risk of type 2 @entity6 and @entity209 (both P<0.0001) both in Australian and Chinese populations. The FEV1 associated with the lowest risk of type 2 @entity6 and @entity209 was above 2.70L (95%CI: 2.68 to 2.72L and 2.65 to 2.76L in Chinese and Australian populations respectively). The discrimination of the model could be significantly improved using the FEV1 threshold both in the Australian and Chinese populations. CONCLUSIONS: In both Australian and Chinese populations, the risk of type 2 @entity6 and @entity209 is lowest with a FEV1 of 2.65-2.76 L. This might be used in clinical practice in different countries as a prompt to screen for type 2 @entity6 and @entity209 in @entity1 with @entity3885 and to ensure there was no abnormal @entity413 metabolism before the commencement of @entity230 if indicated. This article is protected by copyright. All rights reserved.
