Arizona Study of Aging and XXXX and Brain and Body Donation Program.

@entity64 @entity5 @entity16 @entity191 @entity179 @entity74 @entity195 @entity717 @entity204
UNASSIGNED: The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and @entity179 (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also directed at subjects with @entity195 , @entity191 and @entity5 . The median age at @entity204 is 82. Subjects receive standardized general medical, neurological, neuropsychological and @entity717 assessments during life and more than 90% receive full pathological examinations by medically licensed pathologists after @entity204 . The Program has been funded through a combination of internal, federal and state of Arizona grants as well as user fees and pharmaceutical industry collaborations. Subsets of the Program are utilized by the US National Institute on Aging Arizona @entity195 Core Center and the US National Institute of @entity16 and @entity64 National Brain and Tissue Resource for @entity191 and @entity74 . Substantial funding has also been received from the Michael J. Fox Foundation for @entity191 . The Program has made rapid autopsy a priority, with a 3.0-hour median post-mortem interval for the entire collection. The median RNA Integrity Number (RIN) for frozen brain and body tissue is 8.9 and 7.4, respectively. More than 2500 tissue requests have been served and currently about 200 are served annually. These requests have been made by more than 400 investigators located in 32 US states and 15 countries. Tissue from the BBDP has contributed to more than 350 publications and more than 200 grant-funded projects.
