Efficacy and Safety of Exercise Training in XXXX : A Systematic Review and Meta-Analysis.

@entity1 @entity410 @entity712 @entity26 @entity120 @entity1030
BACKGROUND: -Exercise training has been shown to improve @entity410 , physical capacity and quality of life in @entity1 with cardiopulmonary conditions such as @entity712 and @entity1030 . However, its role in management of @entity120 is not well defined. In this study, we aim to evaluate the efficacy and safety of exercise training in @entity1 with @entity120 . METHODS AND RESULTS: -We included all prospective intervention studies that evaluated the efficacy and safety of exercise training in @entity1 with @entity120 . Primary outcome of this meta-analysis was a change in six-minute walk distance (6MWD). We also assessed the effect of exercise on peak @entity26 uptake (VO2peak), resting pulmonary arterial systolic pressure (PASP), peak exercise heart rate (HRpeak), and quality of life. A total of 16 studies with 434 exercise-training @entity1 were included. In the pooled analysis, exercise training was associated with significant improvement in 6MWD [Weighted mean difference (WMD): 57.7 meters (95% CI: 42.5 to 72.8)], VO2peak [WMD = 1.7 ml/kg/min (95% CI: 1.3 to 2.0)], PASP [WMD = -3.6 mmHg (95% CI = -5.8 to -1.4)], HRpeak [WMD = 10.4 beats per min (95% CI: 5.5 to 15.3)], and quality of life as measured on SF-36 questionnaire subscale scores. Furthermore, exercise training was well tolerated with a low dropout rate and no major adverse events related to exercise training. CONCLUSIONS: -Exercise training in @entity1 with @entity120 appears safe and is associated with a significant improvement in exercise capacity, pulmonary arterial pressure and quality of life.
