XXXX and the pill--a further report from the Royal College of General Practitioners' oral contraception study.

@entity1 @entity3942 @entity0 @entity2931
An analysis of the occurrence of @entity0 in this long-term prospective cohort study shows a significant relative risk (RR) in @entity1 who have ever used oral contraceptives (OC) of 3.33 in @entity1 age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in @entity1 who were parity 1 at the time of diagnosis. In @entity1 below the age of 35 years the RR of 2.38 was not significant. There was no increased risk in @entity1 over the age of 35 years. A significant trend relating to duration of use was demonstrable in @entity1 who were parity 1 in the analysis of both current and ever-users. An analysis by time since stopping OC use revealed a significant trend in all ever-users, but the trends were much steeper in @entity1 of parity 1 or aged 30 to 34 years at diagnosis. There was no evidence that the increased rates in OC users were related to the @entity2931 or @entity3942 dose. The 5 year survival rate in users diagnosed under the age of 35 years was significantly poorer than in comparable non-users. It is possible that the increased rates in younger OC users might be due to an accelerated presentation of @entity0 in those @entity1 who would otherwise have been diagnosed at a later time. The non-significant excess risk in users under 35 years of age was approximately 1 in 7,000 users per year. The unresolved discrepancies between the results of the published studies make it impossible at the present time to decide whether or not OC use is associated with an increased risk of @entity0 .
