Diagnostic accuracy of circulating thyrotropin receptor messenger RNA  combined with neck ultrasonography in XXXX with Bethesda III-V thyroid cytology.

@entity1 @entity66 @entity5 @entity2286 @entity5010
BACKGROUND: The aim of this study was to analyze the usefulness of thyrotropin receptor messenger RNA ( @entity5010 -mRNA) combined with neck ultrasonography (US) in the management of thyroid nodules with Bethesda III-V cytology. METHODS: Cytology slides of @entity1 with a preoperative fine needle aspiration (FNA) and @entity5010 -mRNA who underwent thyroidectomy between 2002 and 2011 were recategorized based on the Bethesda classification. Results of thyroid FNA, @entity5010 -mRNA, and US were compared with the final pathology. Sensitivity, specificity, positive predictive value ( @entity2286 ), and negative predictive value (NPV) were calculated. RESULTS: There were 12 @entity1 with Bethesda III, 112 with Bethesda IV, and 58 with Bethesda V cytology. The sensitivity of @entity5010 -mRNA in predicting @entity5 was 33%, 65%, and 79 %, and specificity was 67%, 66%, and 71%, for Bethesda III, IV, and V categories, respectively. For the same categories, the @entity2286 of @entity5010 -mRNA was 25%, 33%, and 79%, respectively; whereas the NPV was 75%, 88%, and 71%, respectively. The addition of neck US to @entity5010 -mRNA increased the NPV to 100% for Bethesda III, and 86%, for Bethesda IV, and 82% for Bethesda V disease. CONCLUSION: This study documents the potential usefulness of @entity5010 -mRNA for thyroid nodules with Bethesda III-V FNA categories. @entity5010 -mRNA may be used to exclude @entity66 . A large sample analysis is needed to determine its accuracy for Bethesda category III nodules.
