[The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein ( @entity2301 ) during the maintenance therapy and after remissionof @entity981 ( XXXX )].

@entity1 @entity981 @entity2301 @entity442 @entity209 @entity1499 @entity214
INTRODUCTION: Antineoplastic therapy may cause @entity209 , which result in e.g. abnormal growth rate. The aim of the study was the assessment of @entity442 and @entity2301 plasma concentrations in @entity1 after intensive therapy of @entity981 completed according to age, weight, height and therapy protocols ( @entity1499 dose, Central Nervous System - CNS prophylaxis). MATERIALS AND METHODS: 63 @entity1 (43 @entity1 ) were involved in this study with mean age 10.95+/-4.73 years after @entity981 therapy according to BFM protocols. 35 @entity1 were in maintenance therapy and 28 completely finished the therapy. 20 @entity1 had cranial irradiation as CNS prophylaxis (12 Gy). We assessed plasma levels of @entity442 and @entity2301 in radioimmunoassay method and the obtained results were related to mean age values ( @entity214 core). RESULTS: 1. A) @entity442 mean plasma levels in @entity1 (n=30) before puberty (Tanner I) was 151.48+/-75.75 ng/ml and was lower than compared to value in the puberty group (n=16, Tanner II-IV) - 222.06+/-96.61 ng/ml p=0.000008. After puberty (Tanner V) @entity442 was 332.03+/-75.66 ng/ml. b) @entity2301 was highest after puberty (3837.4 ng/ml +/-598.49); before puberty it was 2899.68+/-656.57 ng/ml, and in puberty it was 3593.14+/-598,49 ng/ml. 2. @entity442 @entity214 values were lower than mean age values. 3. @entity2301 @entity214 were insignificantly higher than mean age values. 4. There were no differences between @entity442 @entity214 and @entity2301 @entity214 according to gender, prior CNS prophylaxis, @entity1499 dose and phase of maintenance therapy and completed therapy. 5. @entity442 and @entity2301 correlated to each other and to body mass index, height but @entity442 @entity214 and @entity2301 @entity214 was independent on age, CNS prophylaxis, BMI @entity214 and height @entity214 . CONCLUSIONS: 1. @entity442 and @entity2301 values are dependent on puberty degree, body mass index and height. 2. @entity442 @entity214 are lower and @entity2301 values higher, independent on gender, therapy protocol and CNS prophylaxis (12 Gy).
