Complement C4 induces regulatory T cells differentiation through XXXX .

@entity1 @entity1252 @entity2533 @entity792 @entity10287
BACKGROUND: @entity1252 ( @entity1252 ) is a prototypic @entity792 . Complement component 4 ( @entity10287 ) has be proved to play a role in pathogenesis of @entity1252 . In the present study, we investigated the effect of @entity10287 on T cells differentiation. METHODS: Thirty @entity1252 @entity1 were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or @entity1252 @entity1 . @entity10287 was supplemented to co-incubate with T cells and DCs. RESULTS: Serum @entity10287 concentration was positively correlated with regulatory T cell (Treg) percentage (R(2)  =  0.5907, p  <  0.001) and @entity2533 concentration (R(2)  =  0.5641, p  <  0.001) in @entity1252 @entity1 . Different concentrations of @entity10287 had no effect on T cells differentiation. Co-incubated T cells with DCs and @entity10287 for 7  days, the Treg percentage and @entity2533 concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or @entity1252 @entity1 ) with @entity10287 and then co-incubated with T cells, the increases of Treg percentage and @entity2533 concentration were also observed. CONCLUSION: @entity10287 takes part in T cells differentiation to Treg cells via DCs.
