Colonic dysplasia and @entity5 in XXXX .

@entity1 @entity5 @entity29 @entity14 @entity30
@entity5 are a relatively rare complication of @entity29 . In contrast, @entity14 remains a major concern for @entity1 with long-standing UC. The best available evidence suggests that @entity1 with long-standing @entity30 are at similar risk for @entity14 as those @entity1 with long-standing UC. In @entity1 with UC, the magnitude of this increased risk appears to be greater in @entity1 with more extensive colonic involvement. It appears that the magnitude of this risk increases with increasing duration of disease, at least in UC. Whether this reflects the increased risk of @entity5 that occurs with the aging process or a separate phenomena distinct to UC is unclear. To date, the methods available to reduce the risk of @entity5 are less than optimal. Although surgical procedures eliminate the risk, the mental and physical sequelae of these procedures can be substantial. Surveillance with colonoscopic biopsies is likely effective in reducing although not eliminating the risk of @entity14 . Efforts to develop chemopreventative agents and improved surveillance methods remain areas of active investigation.
