Prognostic significance of stromal metalloproteinase-2 in XXXX and its relation to @entity189 progression.

@entity43 @entity1 @entity1552 @entity1476 @entity5 @entity189 @entity420 @entity1551 @entity204 @entity4348
OBJECTIVES: @entity1476 expression in @entity43 cells has been correlated with poor prognosis. This study attempts to assess the prognostic importance of stromal @entity1476 in @entity1 with @entity43 . METHODS: @entity1476 , @entity1476 activator, @entity1551 , and its inhibitor ( @entity1552 ) were immunostained in 84 @entity43 (EOCs) (35 @entity4348 [ @entity4348 ] and 49 @entity420 [ @entity420 ]). Results were correlated to pathological subtypes, @entity5 stage, grade, size, and to recurrence-free and @entity5 -specific survival. RESULTS: @entity1476 and stromal @entity1476 were detected in all @entity189 cells of 22.2% of EC and 77.8% of SC @entity5 . @entity1551 co-localized with @entity1476 . @entity1552 staining was weak and cytoplasmically distributed in all @entity5 . Univariant analysis showed expression of stromal @entity1476 significantly associated with advanced stage (P = 0.018), higher grade (P = 0.005), serous subtype (P = 0.02), smaller @entity5 size at operation (P = 0.001), and higher incidence of recurrence (P = 0.042), but not with the rate of @entity204 due to @entity5 . By multiple Cox proportional hazard regression analysis, @entity1 survival and disease-free survival were significantly related to the presence of stromal @entity1476 in EC but not SC @entity1 (P < 0.05). However, after multivariant analysis, the associations with @entity1 age, @entity5 stage, grade, and size no longer existed. In stepwise selection, @entity5 stage remained the most important predictor of @entity1 survival and disease-free survival in ovarian EC and SC, but stromal @entity1476 remained the most important predictor of recurrence-free survival in @entity1 with EC. CONCLUSIONS: Stromal @entity1476 occurs early and may play a role early in EOC invasion. @entity5 stage and stromal @entity1476 are important predictors of disease-free survival.
