Head-to-Head Comparison of the Neuropsychiatric Effect of Dopamine Agonists in XXXX : A Prospective, Cross-Sectional Study in Non-demented @entity1 .

@entity1 @entity3034 @entity25049 @entity146 @entity191 @entity399
INTRODUCTION: Dopaminergic agonists (DAs) are widely used to treat motor symptoms in @entity191 ( @entity191 ). The differential effect of DAs on neuropsychiatric symptoms of @entity191 has not been accurately studied. MATERIALS AND METHODS: We performed a prospective cross-sectional study of 515 non-demented @entity191 @entity1 receiving treatment with @entity399 [n = 250, monotherapy or with @entity3034 ( @entity3034 )], @entity25049 (n = 150, monotherapy or with @entity3034 ), or @entity3034 (n = 115, monotherapy); all formulations were immediate release. Neuropsychiatric disturbances were assessed through the Neuropsychiatric Inventory (NPI). Groups were matched in terms of age, education, sex, disease severity (Hoehn and Yahr), disease duration, executive function, total @entity3034 daily equivalent dose, and concomitant psychotropic medications (antidepressants, anxiolytics and antipsychotic agents). RESULTS: @entity1 on @entity399 showed significantly lower total NPI scores than @entity1 on @entity25049 (17.2    11 vs. 20.9    13, p = 0.015). Regarding the spectrum of neuropsychiatric symptoms, @entity399 was associated with significantly lower apathy scores than the @entity3034 group (1.01    1.7 vs. 1.87    2.93, p = 0.02). The frequency of @entity1 with clinically meaningful symptoms of apathy (NPI apathy scores >=  4) was significantly lower in the @entity399 group (11.2 %) than in the @entity25049 (20.3 %) and @entity3034 (23.8 %) groups (   (2) 12.49, p = 0.002). No other significant differences were found in NPI subscores between groups. CONCLUSIONS: This is the first head-to-head comparative study of the effect of DAs on @entity146 in @entity191 that has controlled the sample for the most important confounding factors. In comparable groups of @entity1 , the use of @entity399 seems to be associated with a lower frequency and severity of apathetic symptoms.
