XXXX (>3cm) in young adulthood: Pathologic and proliferative characteristics.

@entity1 @entity2013 @entity5 @entity876 @entity4611 @entity2124 @entity977 @entity652
BACKGROUND: There are scarce data regarding the significance of the @entity5 size, hormonal activity and size of the @entity977 of the young; therefore, the study was designed to define the relation of the hormonal status of the large @entity977 . OBJECTIVE: We compared those features with @entity5 of the elderly (>40) with the young @entity1 , and analyzed the clinicopathologic and proliferative features of @entity4611 in young adulthood ( <=40). METHODS: 20-year archives of @entity977 in our clinics were reviewed and macroadenomas with diameter >= 3cm were included in the study. We identified 46 @entity977 and immunohistochemically stained them with pituitary hormones, @entity876 and Ki-67. Twenty-four cases were  <=40-year with an age range of 11-40 years (mean 28.0). Twenty-two cases were >40 with an age range of 44-78 years (mean 58.8). RESULTS: In the young @entity1 group, 15 (62.5%) were functional @entity652 (6 @entity2013 , six @entity2124 [ @entity2124 ], one adrenocorticotrophic hormone [ACTH] @entity652 , two multihormonal [ @entity2124 +ACTH]) and nine (37.5%) were either gonadotrophic or null cell @entity652 . In the elderly group, five (22.7%) were functional @entity652 (two adrenocorticotrophic hormone [ACTH] @entity652 , one @entity2013 , one @entity2124 [ @entity2124 ], one multihormonal [ @entity2124 +ACTH]) and 17 (77.3%) were either gonadotrophic or null cell @entity652 . Ki-67 proliferation index in @entity652 of the young was approximately two-folds higher than the elderly (2.7% vs. 1.2%). CONCLUSION: In both groups, rare @entity876 positivity was identified. In conclusion, @entity4611 of the young show hormonal expression frequently with relatively high Ki-67 proliferation indices.
