Antibiotic Prophylaxis by @entity11248 and Risk of XXXX in Cardiac Surgery.

@entity1 @entity8 @entity5152 @entity177 @entity11248 @entity810 @entity1011
OBJECTIVE: To investigate the risk of @entity810 ( @entity810 ) associated with antibiotic prophylaxis with @entity11248 in cardiac surgery. DESIGN: Observational cohort study. Data were gathered from @entity1 charts and national registers. SETTING: University hospital. @entity1 : All adult @entity1 who underwent cardiac surgery at the authors' institution between January 1, 2010 and July 31, 2013 were eligible for the study. INTERVENTIONS: The risk for @entity810 associated with @entity11248 prophylaxis was estimated by multivariate logistic regression. MEASUREMENTS AND MAIN RESULTS: The primary endpoint, @entity810 , was defined according to the @entity810 Network criteria stage 1, as an increase of postoperative serum @entity1011 by>= 26  mol/L (>= 0.3 mg/dL) or a relative increase of>= 50% compared to the preoperative value. The authors included 2,809 @entity1 , and 1,056 (38%) received a combination of @entity11248 and @entity5152 for antibiotic prophylaxis. The remaining 1,753 (62%) @entity1 received only @entity5152 and constituted the control group. @entity810 occurred in 32% (n = 343) in the @entity11248 group compared to 29% (n = 517) in the control group. There was a significant association between antibiotic prophylaxis with @entity11248 and @entity810 ; multivariate adjusted odds ratio (OR): 1.41 (95% confidence interval [CI] 1.18-1.70). There was a dose-dependent relationship; 600 mg OR: 1.48 (95% CI 1.17-1.87), and 400 mg OR: 1.34 (95% CI 1.06-1.71). The findings were confirmed in several subgroup analyses; @entity1 (OR: 1.27; 95% CI 1.03-1.56); @entity1 (OR: 1.90; 95% CI 1.30-2.80); normal renal function (OR: 1.31; 95% CI 1.07-1.60), and @entity177 (OR: 1.80; 95% CI 1.13-2.85). CONCLUSIONS: Antibiotic prophylaxis with @entity11248 was associated with an increased risk of @entity810 after cardiac surgery. The relative risk of @entity810 was higher in @entity1 and in @entity1 with @entity8 .
