The role of XXXX gene polymorphism in childhood immune thrombocytopenic purpura.

@entity1 @entity1423 @entity43873 @entity3039 @entity5812 @entity669 @entity792
@entity3039 is an @entity792 characterized by antibody-mediated @entity1423 . A protein @entity669 phosphatase ( @entity5812 ) present in lymphocytes is an important negative regulator of signal transduction for the T-cell receptor-MHC complex and has been associated with @entity792 that produce autoantibodies. The present study investigated the frequency of the @entity43873 single-nucleotide polymorphism (SNP) in the @entity5812 gene in @entity3039 ( @entity3039 ) @entity1 . This case series study included 50 @entity1 with @entity3039 , 24 acute and 26 chronic cases, and 50 normal @entity1 as a control group. All were subjected to clinical history and laboratory investigations including complete blood count, genotyping of @entity5812 @entity43873 SNP by polymerase chain reaction-restriction fragment length polymorphism and platelet antibodies using platelets suspension immunofluorescence test for the cases. Thirteen @entity1 (26%) were positive for the @entity5812 @entity43873 SNP. Three @entity1 were homozygous for the mutation and 10 were heterozygous. Comparison of the 26% of the @entity3039 @entity1 who were positive for the @entity5812 @entity43873 mutation with the 6% positive in the control group yielded a P value of 0.006. Antiplatelet antibodies were detected in five @entity1 (20.8%) with @entity3039 and in three @entity1 (11.5%) with chronic @entity3039 ; no significant association between the presence of @entity5812 @entity43873 mutation and the presence of antiplatelet antibodies was detected. The prevalence of @entity5812 gene mutation was higher in @entity3039 @entity1 , thus it may be considered as a genetic risk factor in the development of @entity3039 in Egyptian @entity1 .
