Hormone receptor-independent @entity371 production is associated with the regulation of cellular factors linked to XXXX progression and @entity3 .

@entity1 @entity3334 @entity0 @entity5 @entity3963 @entity584 @entity7952 @entity3546 @entity98 @entity14520 @entity3 @entity373 @entity371 @entity372 @entity436
UNASSIGNED: @entity0 ( @entity0 ) is a major health problem for @entity1 around the world. Although advances in the field of molecular therapy have been achieved, the successful therapeutic management of @entity0 , particularly metastatic disease, remains a challenge for @entity1 and clinicians. One of the areas of current investigation is the circulating @entity5 cells (CTCs), which have a determinant role in the development of distant @entity3 . At the present, many of the available treatment strategies for metastatic disease are of limited benefit. However, the elucidation of the mechanisms of @entity5 progression and @entity3 may help to identify key molecules/components that may function as therapeutic targets in the future. In the present study, the functional analysis of CTCs revealed their ability to grow and proliferate to form colonies. Immunofluorescence staining of the CTCs' colonies exhibits elevated expression of cell growth and survival associated proteins such as, survivin, @entity3963 and @entity584 . More importantly, the functional screening of the chemokine profile in @entity0 @entity1 ' sera revealed an HR-independent elevation of the chemokine @entity371 when compared to healthy controls. The analysis of chemokines @entity373 and @entity372 demonstrated an HR-dependent production pattern. The levels of both @entity373 and @entity372 were markedly high in HR+ @entity1 ' sera when compared to HR- @entity1 and healthy controls. The functional analysis of HR+ and HR- @entity0 derived cell lines when cultivated in media supplemented with @entity1 ' sera demonstrated the alteration of @entity5 progression and @entity3 related proteins. We noted the induction of survivin, @entity3546 , @entity14520 , @entity7952 , @entity436 and @entity3334 both at the protein and mRNA levels. The induction of those proteins was in keeping with @entity1 ' sera induced cell proliferation as measured by the @entity98 assay. In conclusion, our data emphasizes the role of chemokines, especially @entity371 , in @entity0 progression and @entity3 via the induction of signaling pathways, which mainly involve survivin, @entity3546 , @entity14520 and @entity3334 .
