Comparison between magnesium sulfate and dexmedetomidine in controlled XXXX during functional endoscopic sinus surgery.

@entity1 @entity551 @entity548
BACKGROUND AND OBJECTIVES: It is crucial to decrease @entity548 during functional endoscopic sinus surgery. Our primary goal was to investigate the effects of magnesium sulfate and dexmedetomidine used for controlled @entity551 on the visibility of the surgical site. METHODS: 60 @entity1 aged between 18 and 65 years were enrolled. In the magnesium sulfate group (Group M), @entity1 were administered 40mg/kg magnesium sulfate in 100mL saline solution over 10min as the intravenous loading dose 10min before induction, with a subsequent 10-15 g/kg/h infusion during surgery. In the dexmedetomidine group (Group D), @entity1 were administered 1 g/kg dexmedetomidine in 100mL saline solution as the loading dose 10min before surgery and 0.5-1 g/kg/h dexmedetomidine during surgery. Deliberate @entity551 was defined as a mean arterial pressure of 60-70mmHg. RESULTS: Bleeding score was significantly decreased in Group D (p=0.002). Mean arterial pressure values were significantly decreased in Group D compared to that in Group M, except for the initial stage, after induction and 5min after intubation (p<0.05). The number of @entity1 who required nitroglycerine was significantly lower in Group D (p=0.01) and surgeon satisfaction was significantly increased in the same group (p=0.001). Aldrete recovery score >= 9 duration was significantly shorter in Group D (p=0.001). There was no difference between the two groups in terms of recovery room verbal numerical rating scale. CONCLUSIONS: Dexmedetomidine can provide more effective controlled @entity551 and thus contribute to improved visibility of the surgical site.
