Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for XXXX .

@entity1 @entity26407 @entity101 @entity117 @entity1592 @entity2431
INTRODUCTION: @entity1592 ( @entity1592 ) is associated with poor perinatal outcomes. Screening and prevention tools for @entity1592 , such as uterine artery Doppler imaging and @entity117 , underperform in high-risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early prediction of @entity1592 in high-risk pregnancies. MATERIALS AND METHODS: This was a prospective observational study based in a dedicated antenatal @entity101 clinic at a tertiary UK hospital. We assessed maternal demographic and central hemodynamic variables as predictors for @entity1592 in a group of @entity1 at high risk for @entity2431 due to chronic @entity101 (n = 55) or a history of @entity101 in a previous pregnancy (n = 71). Outcome variables were birthweight z-score as well as development of @entity1592 (defined as birthweight below the 5th or 3rd centile). Maternal hemodynamics were assessed using a noninvasive transthoracic bioreactance monitor ( @entity26407 NICOM). RESULTS: The mean gestation at presentation was 13.6 (range: 8.5-19.5) weeks. Sixteen @entity1 delivered babies below the 5th centile. Ten of these were below the 3rd centile. Independent predictors of birthweight z-score were body surface area, peripheral vascular resistance and white ethnicity (R(2) = 0.26, p < 0.0001). Independent predictors of @entity1592 were maternal height and cardiac output. The area under the receiver operator characteristic curve for prediction of @entity1592 was 0.915 (95% CI 0.859-0.972) and 0.9079 (95% CI 0.823-0.990) for @entity1592 below the 5th and 3rd centiles, respectively. CONCLUSION: In @entity1 with chronic @entity101 or a history of @entity101 in a previous pregnancy, maternal size and cardiac output at booking provide a sensitive screening tool for @entity1592 .
