Treatment Strategy of Intracranial XXXX .

@entity1 @entity932 @entity2698 @entity5 @entity1753 @entity86 @entity3
BACKGROUND: Recent studies suggest aggressive management combining a grossly total resection (GTR) with adjuvant radiotherapy (RT) as a treatment of choice for @entity932 ( @entity2698 ). However, in these papers, the definitions of complete or GTR are equivocal. In the present study, we reviewed the relevant cases from our experience focused on the clinical efficacy of surgical grading of resection, and analyzed the optimal treatment strategies as well. METHODS: From January 1995 through December 2014, 17 @entity1 treated for intracranial @entity2698 were included in this study. We analyzed clinical presentation, radiologic appearance, pathologic diagnosis, extent of resection, and follow-up outcomes. RESULTS: A total of 26 operations were performed including 9 recurrent intracranial HPCs. Every @entity5 was single and had no evidence of @entity3 . Most common area of @entity5 was parasagittal (8 @entity1 , 47.1%), which is adjoined to superior sagittal sinus. For the initial operation, GTR was performed in 16 cases (61.5%), partial resection (PR) in 8 cases (30.8%), and an endoscopic biopsy in 2 @entity1 (7.7%). In Simpson grading system, grade 1 was done in 2 @entity1 (7.7%), grade 2 in 11 @entity1 (42.3%) and grade 3 in 3 @entity1 (11.5%). @entity86 was delivered in 16 @entity1 (94.1%) regardless of the extent of resection. The median 57.57 Gy (range, 50-60 Gy) was delivered in median 33 fractions (range, 30-40). The extent of resection (conventional classification and Simpson grading system) and adjuvant RT were significantly associated with recurrence-free survival. CONCLUSION: Surgical resection of intracranial @entity2698 , in an attempt to reach Simpson grade 1 removal, is necessary for better outcome. @entity1753 should be done as recommended before, to prevent recurrence, regardless of surgical resection and pathological diagnosis.
