Massive XXXX in the reconstruction of extremities following resection of @entity5 not requiring chemotherapy and radiation.

@entity1 @entity1568 @entity2003 @entity174 @entity3084 @entity5 @entity653 @entity281
Since 1976, 70 @entity3084 have been used to reconstruct extremities from which @entity5 not requiring chemotherapy or radiotherapy have been resected. Allografts excised from cadavers were stored in the vapor phase of liquid @entity1568 in liquid @entity1568 freezers (-150 degrees) after exposure to 15% @entity653 . Prior to their use, the allografts were thawed rapidly in either tissue culture or balanced salt solutions. Following resection of the @entity5 , the excised bone was replaced with allografts that were rigidly internally fixed with plates and screws or, occasionally, with intramedullary rods. @entity1 were observed carefully for complications and were subjected to functional evaluations. Complications did not include alterations suggestive of a pronounced immunologic response to the graft. Five @entity1 developed either local recurrences or distal metastasis. Of the remaining 65 @entity1 , followed for one year or longer, osteochondral allografts performed satisfactorily in 55 (84.6%). This group included eight @entity1 with initial complications that were successfully treated. The group of ten @entity1 with unsatisfactory results included four @entity1 with @entity174 of the grafts, one with fragmentation of the humeral head, three with @entity281 , and two with joint instabilities. Since all @entity1 had either hemi-joint or quarter joint replacements, the overall results achieved so far have been rewarding. However, continued long-term observations of @entity1 with allografts are indicated, as are studies that would allow for the improvement of cartilage preservation, decrease the incidence of @entity174 , and improve @entity2003 of internal fixation. The incidence of infection can be reduced by the improvement in surgical technique, particularly with reference to the wound closure.
