Intestinal colonization of neonatal animals by Campylobacter fetus subsp. XXXX .

@entity1 @entity19 @entity95 @entity1017 @entity35 @entity204 @entity5363
Neonatal @entity19 (2.3 to 2.8 g) were inoculated intragastrically with different @entity1 isolates of @entity5363 . At weekly intervals thereafter, @entity19 were sacrificed and dilution plate counts were performed on segments of the gastrointestinal tract. @entity19 were uniformly colonized by some strains for 2 weeks, whereas other strains were being cleared at that time. One strain (BO216) persisted in some @entity19 for 3 weeks. The greatest number of organisms (10(7)) was recovered from the cecum and large intestine. The small intestine had from 10(2) to 10(5) colony-forming units. Colonization of the stomach was not found consistently. One strain killed 13% of the infected @entity19 . @entity204 occurred between 1 and 5 days postinfection. Two other strains killed a smaller percentage of challenged animals, and two additional strains killed none. Retarded @entity1017 was noticed in some, but not all, of the infected @entity19 . The intestines of neonatal @entity35 and @entity95 were colonized much the same as those of @entity19 , whereas hamsters were resistant to colonization. Preweanling @entity19 , up to about 6.5 to 7.0 g, could be colonized with @entity5363 after intragastric challenge, but weanling @entity19 of larger weight (9.8 g) and young adult @entity19 (18.3 g) could not. Scanning electron photomicrographs of the lower ileum showed campylobacters in and below the dried mucous gel that lines the intestines. The use of this model for additional studies is discussed.
