Low XXXX and High OSI Measured by 3D Cine PC MRI Reflect High Pulmonary Artery Pressures in Suspected Secondary Pulmonary Arterial Hypertension.

@entity1 @entity120 @entity299 @entity2786 @entity1642
PURPOSE: Institutional Review Board (IRB)-approved prospective study was conducted to test whether objective and quantitative hemodynamic markers @entity1642 ( @entity1642 ) and oscillatory shear index (OSI) measured by three-dimensional (3D) cine phase-contrast (PC) can reflect @entity120 ( @entity120 ). @entity1 AND METHODS: Seventeen consecutive @entity1 of suspected secondary @entity120 were examined for pulmonary artery pressures (PAPs) with @entity299 ( @entity299 ) and three-dimensional (3D) cine PC MR. Based on the @entity299 data, @entity1 were subdivided into two groups of 12 non- @entity120 (median age of 74.5 years) and 5 @entity120 (median age of 77 years) @entity1 . Based on 3D cine PC magnetic resonance (MR), hemodynamic parameters including spatially averaged systolic @entity1642 (sWSS), diastolic @entity1642 (dWSS), mean @entity1642 (mWSS), OSI and blood vessel section area (BVSA) at the pulmonary arterial trunk were calculated. Streamline images in the pulmonary arteries were also assessed. All the parameters were compared between non- @entity120 and @entity120 groups. RESULTS: sWSS (N/m(2)) and mWSS (N/m(2)) of @entity120 group was lower than that of non- @entity120 group (0.594    0.067 vs. 0.961    0.590, P = 0.001), (0.365    0.035 vs. 0.489    0.132, P = 0.027). OSI of @entity120 group was higher than that of non- @entity120 (0.214    0.026 vs. 0.130    0.046, P = 0.001). sWSS, mWSS, and dWSS were inversely correlated and OSI was positively correlated to mean @entity2786 or systolic PAP with r values of -0.638 (P = 0.005), -0.643 (P = 0.005), -0.485 (P = 0.049), and 0.625 (P = 0.007); or -0.622 (P = 0.008), -0.629 (P = 0.007), -0.484 (P = 0.049), and 0.594 (P = 0.012), respectively. sWSS was also inversely correlated to BVSA with r value of -0.488 (P = 0.049), and OSI was correlated to BVSA with r value of 0.574 (P = 0.016). Vortex or helical flows were observed more frequently in @entity120 @entity1 . CONCLUSIONS: The low sWSS and mWSS as well as high OSI measured with 3D cine PC MR could be potential hemodynamic markers for the increased PAP in suspected secondary @entity120 @entity1 .
