Postoperative whole lung irradiation with or without XXXX in @entity421 .

@entity1 @entity632 @entity421 @entity5
Thirty-six @entity1 with histologically proven @entity421 of the extremities, treated between September 1975 and April 1978, are the subject of this report. The @entity5 was treated with radical surgery. @entity1 received 2000 cGy whole lung irradiation postoperatively in an attempt to control micrometastases to the lung. Twenty-nine of the @entity1 were given @entity632 (60 mg/m2 IV every 6 weeks for a total dose of 550 mg/m2) in addition to the irradiation. The median, disease-free interval was 118 days for the seven @entity1 treated with lung irradiation only. The median overall survival for these @entity1 is 241 days, with one @entity1 alive with disease. All @entity1 developed lung metastasis. For the 29 @entity1 treated with postoperative lung irradiation and @entity632 , the median disease-free interval was 372 days, and the median overall survival is 843 days. Nineteen of the @entity1 recurred (65.5%). The differences are statistically significant (p less than or equal to 0.003, median disease-free survival and p less than or equal to 0.03, median survival). This study supports the role of whole lung irradiation plus @entity632 , in the control of micrometastases in @entity421 of the extremities and suggests that additional clinical trials are warranted.
