A novel hypothesis for XXXX as a @entity4554 deficiency syndrome.

@entity32 @entity4554 @entity583 @entity101 @entity63 @entity1255 @entity26 @entity715 @entity842 @entity599 @entity1856 @entity731 @entity224 @entity65 @entity165 @entity597
BACKGROUND: Despite a vast literature, @entity731 and the associated @entity63 /reperfusion injuries remain today in many ways a mystery. Why do @entity1856 make and store a supply of @entity165 and @entity597 within the major arteries supplying the heart? Why are treatment programs aimed to suppress certain @entity583 risk factors, such as elevated serum @entity1255 and @entity32 , generally counterproductive? METHODS: Our methods are based on an extensive search of the literature in @entity65 as well as in the area of the unique properties of water, the role of biosulfates in the vascular wall, and the role of electromagnetic fields in vascular flow. Our investigation reveals a novel pathology linked to @entity731 that better explains the observed facts than the currently held popular view. RESULTS: We propose a novel theory that @entity731 can best be explained as being due to @entity4554 deficiency. Furthermore, @entity1856 replenish the supply of @entity165 and @entity597 to the microvasculature, by exploiting the inflammatory agent @entity224 to derive @entity597 from @entity1255 and other @entity599 sources. We argue that the @entity597 anions attached to the glycosaminoglycans in the glycocalyx are essential in maintaining the structured water that is crucial for vascular endothelial health and erythrocyte mobility through capillaries. @entity597 depletion leads to @entity165 accumulation in @entity1856 , because its transport through water-based media depends on sulfurylation. We show that streaming potential induces @entity842 (NO) release, and NO derivatives break down the extracellular matrix, redistributing @entity597 to the microvasculature. We argue that low (less negative) zeta potential due to insufficient @entity597 anions leads to @entity101 and @entity715 , because these responses can increase streaming potential and induce @entity842 mediated vascular relaxation, promoting @entity26 delivery. Our hypothesis is a parsimonious explanation of multiple features of @entity65 . CONCLUSIONS: If our interpretation is correct, then it would have a significant impact on how @entity731 is treated. We recommend a high intake of @entity599 -containing foods as well as an avoidance of exposure to toxicants that may impair @entity597 synthesis.
