XXXX induced by hemodynamic cardiac stress: Differential release of cardiac biomarkers.

@entity1 @entity662 @entity3876 @entity6949 @entity10020 @entity5632 @entity583 @entity130
OBJECTIVE: We explored whether hemodynamic cardiac stress leads to a differential release of @entity130 biomarkers, used in the diagnosis of @entity583 ( @entity583 ). METHODS: In an observational international multicenter study, we enrolled 831 unselected @entity1 presenting with symptoms suggestive of @entity583 to the emergency department. The final diagnosis was adjudicated by two independent cardiologists. Hemodynamic cardiac stress was quantified by levels of @entity3876 ( @entity3876 ). Spearman's rho correlation was used to analyze the correlations between @entity3876 and high-sensitivity cardiac troponin T (hs- @entity10020 ), Siemens @entity6949 -Ultra ( @entity6949 -ultra), CK-MB and @entity5632 . @entity1 were categorized according to the extent of hemodynamic cardiac stress as quantified by @entity3876 tertiles. RESULTS: Among all @entity1 , the positive pair-wise correlation with @entity3876 was strongest with hs- @entity10020 and @entity6949 -ultra (r=0.58 and 0.50, respectively), moderate for @entity5632 (r=0.43), and weakest with CK-MB (r=0.25; p<0.001 for each). Similar pattern of correlations was also observed among @entity583 @entity1 . Among @entity1 diagnosed with non-cardiac cause of @entity662 (n=385, 46%) and cardiac but non-coronary (n=109, 13%), @entity3876 had significant positive correlations with hs- @entity10020 , @entity6949 -ultra and @entity5632 (p<0.05), but not with CK-MB (p=NS). A similar pattern of stronger correlation between @entity3876 and hs- @entity10020 , @entity6949 -ultra and @entity5632 as compared to that with CK-MB was also observed within the higher @entity3876 tertile range. There was no correlation between @entity3876 and other biomarkers within the 1st @entity3876 tertile group. CONCLUSION: Hemodynamic cardiac stress, as quantified by @entity3876 , as a likely cause of @entity130 , is more closely reflected by concentrations of hs- @entity10020 , @entity6949 -ultra and @entity5632 than CK-MB.
