Development of a CT-based weighted rating scale for subcortical XXXX sensitive to mild clinical symptoms.

@entity1 @entity6480 @entity455 @entity66 @entity101 @entity73 @entity2845
OBJECTIVE: To devise and validate a CT-based visual rating scale sensitive to subcortical @entity66 (sCVD) in @entity1 with @entity73 . METHODS: Three types of @entity455 were rated separately in 16 brain regions. A unique vascular score was computed weighing the regression coefficients of the three scores in linear models. Thereafter, subcortical vascular classes ( @entity6480 ) of increasing severity (0-3) were created. Known-group and convergent validity of the @entity6480 was tested in 122 @entity73 @entity1 with MMSE of 18 and higher. These @entity1 were grouped according to clinical diagnosis in degenerative, mixed, and vascular. RESULTS: Intraclass correlation coefficients were between 0.86 and 0.94. The subcortical vascular score was 8.0+/-9.4 in the degenerative, 33.0+/-17.2 in the mixed, and 36.8+/-14.8 in the vascular @entity1 (p=0.0001). In particular, none of the degenerative @entity1 had @entity6480 =3, and only 14% had @entity6480 =2. On the contrary, none of the mixed and vascular @entity1 had @entity6480 =0, while about 50% had @entity6480 =3 in both groups. The prevalence of @entity101 was increasing with increasing @entity6480 (p for trend=0.02). The performance on tasks evaluating balance, gait, and @entity2845 decreased with increasing @entity6480 severity (p for trend=0.006, 0.01, 0.001, respectively). CONCLUSION: The scale is a valid tool to estimate the vascular component in @entity1 with @entity73 .
