Clinical significance of IgG antibody titer against XXXX .

@entity1 @entity5 @entity3202 @entity194 @entity1534 @entity356
BACKGROUND: We clarified the clinical significance of measurement of IgG antibody titers against @entity1534 using data from a nested case-control study from a large-scale cohort study in Japan. METHOD: @entity1 included 36,745 subjects from the Japan Health Center-based Prospective Study who responded to the baseline questionnaire and provided a blood sample. Subjects were aged 40-69 years and were followed over 15 years after initial sampling. Controls were matched to 511 @entity356 @entity1 . Plasma surface antigen (Hp)-IgG titer was measured using ELISA, and @entity194 was determined by measuring pepsinogen I and II levels. RESULTS: Seropositive subjects with low Hp-IgG titer and @entity194 showed a higher risk for @entity356 than high-titer subjects. Odds ratio (OR) referred to cases with true negative IgG titers and no @entity194 . In moderately @entity3202 subjects, the low titer OR was 19.0, with a 95% confidence interval (CI) of 7.7-46.9, and 12.5 for high titer, with a 95% CI of 5.2-30.0. In severely @entity3202 subjects, the low titer OR was almost double that of high-titer subjects (OR = 30.2, 95% CI = 12.4-73.7 and OR = 15.9, 95% CI = 6.3-40.3, respectively). These associations were observed more frequently for differentiated than undifferentiated @entity356 . CONCLUSION: Combination assay with Hp-IgG titer and pepsinogens may help identify groups at high risk for @entity356 . Subjects with low Hp-IgG titer and @entity194 were at extremely high risk for @entity356 , particularly differentiated @entity5 . Subjects with this background may require ongoing observation and periodic endoscopic examination for early @entity5 detection.
