Sequential serum complement (C3) and immunoglobulin levels in shock/ @entity130 XXXX developing @entity15 .

@entity1 @entity295 @entity326 @entity551 @entity204 @entity15 @entity130
The complement system has been implicated in the physiopathology of @entity326 . Since infection is a major cause of @entity204 in @entity130 @entity1 , we examined daily serum C3 and immunoglobulin levels in all victims of major @entity130 during a 3-month interval. Sixteen @entity1 developed acute systemic @entity295 3-15 days after admission. For all variables the lowest values occurred shortly after hospital admission, during or just after fluid resuscitation. Thereafter, the serum C3 and immunoglobulin concentrations gradually returned to the normal ranges, despite the onset of fulminant systemic @entity295 . Except for IgM, the occurrence of @entity551 during @entity295 did not affect the recovery patterns of the measured variables. In the five @entity1 experiencing @entity551 , serum IgM dropped transiently but resumed its normalization trend after the restoration of adequate perfusion pressure. In the three nonsurvivors there was no reduction in the serum C3 or immunoglobulin levels prior to @entity204 . These data do not support a role for C3 or the immunoglobulins in the pathogenesis of @entity15 . On the contrary, the behavior of these substances during severe @entity295 is more consistent with protective host defense functions.
