[Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal XXXX /reperfusion injury in @entity35 ].

@entity22943 @entity2806 @entity2500 @entity16 @entity14455 @entity3733 @entity1188 @entity35
OBJECTIVE: To investigate the neuroprotective effects and dose-response relation by combining JAK-STAT signal pathway inhibitor ( @entity22943 ) with free radical scavenger @entity14455 ( @entity14455 ) in @entity35 subjected to focal @entity2806 /reperfusion (I/R) injury. METHODS: In all @entity35 , the @entity2500 ( @entity2500 ) was produced by occlusion of right internal carotid artery with a nylon monofilament. One hundred male Sprague-Dawley (SD) @entity35 were divided into ten groups according to random digits table, 10 @entity35 were in each group. The first experiment involved I/R model control, @entity3733 ( @entity3733 ) control, normal saline (NS) control, @entity22943 , @entity14455 and combination of @entity22943 and @entity14455 (A+D) groups. The second experiment involved model group and three experimental groups in which various doses of @entity14455 and @entity22943 were administered. The @entity16 ( @entity16 ) were assessed at 24, 48 and 72 hours after reperfusion respectively in both experiments, and all the animals were then decapitated to determine the brain @entity1188 volume after 72 hours. RESULTS: The values of @entity16 in A+D group, @entity22943 group and @entity14455 group were higher than those in model group at 24, 48 and 72 hours after I/R, and their brain @entity1188 volumes were obviously smaller than model group as well (all P<0.05). The brain @entity1188 volume in A+D group was obviously smaller compared with @entity22943 and @entity14455 alone (all P<0.05). The values of @entity16 were higher and the brain @entity1188 volumes were smaller in both high dose and medium dose combination groups than those in low dose combination and model groups respectively (all P<0.05). In addition, brain @entity1188 volumes in high dose group were smaller than medium dose group (P<0.05), but there was no statistically significant difference between low dose and model groups. CONCLUSION: The combined application of @entity22943 and @entity14455 produces a dose-dependent synergistic neuroprotective effect.
