Proficient motor impulse control in @entity191 XXXX with @entity23 and compulsive behaviors.

@entity1 @entity23 @entity935 @entity191
BACKGROUND: @entity191 ( @entity191 ) @entity1 treated with @entity935 agonist therapy can develop maladaptive reward-driven behaviors, known as @entity23 ( @entity23 ). In this study, we assessed if @entity23 @entity1 have evidence of motor-impulsivity. METHODS: We used the stop-signal task in a cohort of @entity1 with and without active symptoms of @entity23 to evaluate motor-impulsivity. Of those with @entity191 , 12 were diagnosed with @entity23 symptoms ( @entity191 ) and were assessed before clinical reduction of @entity935 agonist medication; 12 were without symptoms of @entity23 [ @entity191 -control] and taking equivalent dosages of @entity935 agonist. Levodopa, if present, was maintained in both settings. Groups were similar in age, duration, and severity of motor symptoms, levodopa co-therapy, and total levodopa daily dose. All were tested in the @entity935 agonist medicated and acutely withdrawn (24h) state, in a counterbalanced manner. Primary outcome measures were mean reaction time to correct go trials (go reaction time), and mean stop-signal reaction time (SSRT). RESULTS: @entity23 @entity1 produce faster SSRT than both Healthy Controls, and @entity191 -Controls. Faster SSRT in @entity23 @entity1 is apparent in both @entity935 agonist medication states. Also, we show unique @entity935 medication effects on Go Reaction time (GoRT). In @entity935 agonist monotherapy @entity1 , @entity935 agonist administration speeds GoRT. Conversely, in those with levodopa co-therapy, @entity935 agonist administration slows. DISCUSSION: @entity191 @entity1 with active @entity23 symptoms are significantly faster at stopping initiated motor actions, and this is not altered by acute @entity935 agonist withdrawal. In addition, the effect of @entity935 agonist on GoRT is strongly influenced by the presence or absence of levodopa, even though levodopa co-therapy does not appear to influence SSRT. We discuss these findings as they pertain to the multifaceted definition of 'impulsivity,' the lack of evidence for motor-impulsivity in @entity191 , and @entity935 effects on motor-control in @entity191 .
