Electrocardiographic changes at the onset of XXXX .

@entity1 @entity410 @entity1625 @entity591 @entity1315 @entity302 @entity1168
PURPOSE: We studied heart-rate (HR) changes at the transition from the preictal to the ictal state in @entity1 with @entity1625 to gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. METHODS: We assessed ECG changes during 145 @entity410 recorded with scalp EEG in 58 @entity1 who underwent video-EEG monitoring. Consecutive RR intervals were analyzed with a newly developed mathematical method for a total of 90 s. RESULTS: Ictal-onset @entity591 occurred in 86.9% of all @entity410 , whereas @entity1168 was documented only in 1.4%. The incidence as well as the amount of ictal HR increase was significantly more pronounced in @entity1 with mesial @entity1315 ( @entity1315 ) as compared with those with non-lesional @entity1315 or @entity302 . Moreover, right hemispheric @entity410 were associated with ictal-onset @entity591 . On average, ictal HR increase preceded EEG @entity410 onset by 13.7 s in @entity1315 @entity1 and 8.2 s in @entity1 with @entity302 . This difference was significant. Ictal HR changes could be classified according to their temporal evolution into two different patterns. These two patterns differed significantly between the temporal lobe and the @entity302 @entity1 group. CONCLUSIONS: @entity302 directly influence areas of the central autonomic network, thus regulating HR and rhythm. Such changes occur before ictal discharges appear on surface electrodes. Our newly developed method may be of potential use for clinical applications such as @entity410 systems. Moreover, our method might help to clarify further the basic mechanisms of interactions between heart and brain.
