[Loss of fragile @entity3793 triad expression and @entity3 in XXXX ].

@entity1 @entity3821 @entity0 @entity3793 @entity5 @entity1792 @entity406 @entity189 @entity513 @entity982 @entity3 @entity21900
BACKGROUND _ OBJECTIVE: Fragile @entity3793 triad( @entity21900 ), a @entity5 suppressor candidate gene, encompasses @entity21900 , a common region with the highest fragility in the @entity1 genome, and is altered in a large number of @entity1 @entity5 , particularly those of epithelial cell origin and associated with known carcinogenic agents. The aim of this study was to investigate the expression of @entity21900 protein, @entity21900 and the possible relationship between @entity21900 expression and clinicopathological indices in @entity0 . METHODS: @entity21900 protein expression in 66 cases of @entity406 -fixed, @entity982 -embedded @entity0 composed of 6 in situ and 60 @entity513 were detected with @entity1792 -microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to @entity1 @entity21900 gene protein and relationships to invasion and lymphatic @entity3 were analyzed. RESULTS: Thirty-eight (57.6%) cases of @entity189 showed a marked loss or absence of @entity21900 expression compared with the adjacent non-cancerous breast tissues, in which 22 cases were negative. The remain 18 (27.3%) showed stronger than, and 10 (15.2%) equal to the @entity21900 expression of the adjacent non-cancerous tissue. The lower expression of @entity21900 was found in 20/24(83.3%) cases with local or axillary lymphatic @entity3 , and in 18/36 (50%) cases without @entity3 in the @entity513 . @entity21900 expression was determined in all 6 cases of @entity3821 did not show lower than non-cancerous tissue. There was a significant difference in the expression of @entity21900 between the @entity0 with and without lymphatic @entity3 , both in @entity513 (P < 0.01) and in @entity513 (P < 0.01). CONCLUSIONS: The expression of @entity21900 is associated with invasion and @entity3 of @entity5 in @entity0 . It is suggested that decreased @entity21900 expression may play an important role in the development and progression of the @entity5 , and thus may become a new prognostic marker for @entity0 .
