Prognostic factors of reirradiation for recurrent XXXX .

@entity1 @entity135 @entity957 @entity5
We analyzed outcomes and prognostic factors to assess the value of reirradiation for recurrent @entity135 . Forty-four @entity1 with recurrent @entity957 had undergone external beam reirradiation with cumulative dosing of more than 80 Gy. Six and 38 cases exhibited recurrent stage III and stage IV @entity5 , respectively. The complete response rate was 32%. Median relapse-free survival time was 4 months, and the 5-year survival was 6%. The major prognostic factor was anatomical location (p < 0.0001). Favorable sites were the nasopharynx, larynx, or oropharynx; unfavorable sites were the oral cavity, nasal cavity, or hypopharynx. Poorly differentiated @entity5 , no prior surgery, cumulative dose more than 125 Gy, and overlapping field less than 40 cm2 between the initial and reirradiation fields were also favorable factors. Multivariate analysis revealed that anatomical location and overlapping field were significant (0.001 and 0.019, respectively) in relapse-free survival. On exclusion of anatomical location from the analysis, history of prior surgery, and cumulative dose were significant (p = 0.002 and p = 0.023, respectively). Severe late complications occurred in only 1 of 14 (7%) @entity1 followed up for longer than 1 year. Reirradiation would be indicative for nasopharyngeal, oropharyngeal, or @entity5 with small overlapping field, or @entity5 receiving a cumulative dose more than 125 Gy without prior surgery.
