The effect of intraoperative XXXX on postoperative catheter-related bladder discomfort in @entity1 undergoing transurethral @entity150 resection: A prospective, double-blind, randomised study.

@entity1 @entity1340 @entity1494 @entity150 @entity10233 @entity6948 @entity282
BACKGROUND: @entity1494 ( @entity1494 ) due to an indwelling urinary catheter causes postoperative distress. @entity6948 is used as an anaesthetic adjuvant during general anaesthesia and has an antimuscarinic effect, which may be beneficial for the prevention and treatment of @entity1494 . OBJECTIVE: To determine the effect of intraoperative @entity6948 administration on the incidence of @entity1494 . DESIGN: A prospective double-blind, placebo-controlled, randomised study. SETTING: A tertiary care teaching hospital. @entity1 : One-hundred and nine @entity1 undergoing transurethral @entity150 excision (TURB). INTERVENTIONS: @entity1 were randomly allocated to two groups: control group (n=55) received placebo and @entity6948 group (n=54) received intraoperative @entity6948 (1 gkg loading dose followed by 0.5 gkghcontinuous infusion). MAIN OUTCOME MEASURES: The incidence and severity (mild, moderate, severe) of @entity1494 assessed at 0, 1, 6 and 24h postoperatively. RESULTS: The incidence of @entity1494 was significantly higher in the control group at 0 (78 vs. 50%; P=0.004), 1 (86 vs. 57%; P=0.002) and 6h (82 vs. 63%; P=0.047) postoperatively. The incidence of moderate to severe @entity1494 was higher in the control group at 0 (38 vs. 11%; P=0.002) and 1h (29 vs. 7%; P=0.006) postoperatively. The number of @entity1 having @entity1494 treated with @entity1340 was higher in the control group (24 vs. 12; P=0.006). The mean end-tidal desflurane concentration during the surgery was higher in the control group (4.5 vs. 3.9%; P=0.04). The @entity282 score (numerical rating scale: 0 to 10) was higher in the control group at 0 (4.6 vs. 2.7; P=0.002), and 1h (3.8 vs. 2.7; P=0.041). The number of @entity1 treated with opioids was higher in the control group (21 vs. 8; P=0.011). CONCLUSION: Intraoperative @entity6948 administration decreased the incidence and severity of early postoperative @entity1494 as well as intraoperative @entity10233 and postoperative opioid requirements in @entity1 undergoing TURB. TRIAL REGISTRATION IDENTIFIER: NCT01991223 (www.clinicaltrials.gov).
