[Lymphocyte apoptosis in XXXX treated with transfer factor].

@entity1 @entity483 @entity1197
BACKGROUND: @entity483 is an inflammatory dysfunction in whose physiopathology the lymphocytes T play an important role in the regulation of the inflammatory process. OBJECTIVE: To determine and to characterize the role of apoptosis of lymphocytes in @entity1 with moderate to severe @entity483 before and after treatment with transfer factor. MATERIAL AND METHODS: Fifteen @entity1 with moderate to severe @entity483 in a range of age from 5 to 45 were included in the study. Fifteen healthy subjects were taken as a control group. In all subjects it was determined the apoptosis of the lymphocytes by means of annexin and TUNEL techniques, as well as the expression of @entity1197 cells. The 15 @entity1 with @entity483 received treatment with transfer factor in stepped dose as follows: 1 U/day/5 doses, 1 U/week/3 doses, 1 U/15 days/2 doses, 1 U/30 days, until completing three months. At the end of this period new determinations were done to measure apoptosis of lymphocytes and PMN. At the beginning and at the end assessments of the severity in relation to the scale SCORAD were made. RESULTS: By means of both techniques no significant difference was found in the percentage of apoptotic lymphocytes between @entity1 and control subjects. Differences of the expression of @entity1197 between @entity1 and control subjects before and after treatment were not significant. There was a significant difference (p < 0.01) of severity from the beginning to the end of treatment with transfer factor in @entity1 with @entity483 . CONCLUSION: No significant differences of apoptosis of lymphocytes were found in @entity1 with @entity483 who received treatment and control subjects, neither before not after the treatment with transfer factor. It was verified the decrease in the severity of the symptoms related to the treatment with transfer factor.
