Cytogenetic characteristics of therapy-related acute nonlymphocytic leukaemia, preleukaemia and XXXX : correlation with clinical data for 61 consecutive cases.

@entity1 @entity981 @entity697 @entity854 @entity393
Cytogenetic studies were performed on a new series of 23 @entity1 with therapy-related @entity981 , preleukaemia or an @entity697 . In our total series of now 61 cases studied by chromosome banding techniques, at least one of the abnormalities -7, 5q-, 7q- or -5 or some related unbalanced translocations, primarily -7, +t(1q7p), was observed in 40 @entity1 . The critical region for the deletions of chromosome no. 5 comprises bands 5q22 to 5q33 and of chromosome no. 7 bands distal to 7q22. The third most frequently involved chromosome was no. 21, rearranged at band 21q22 in the three @entity1 with 21q+ and in one @entity1 with 21q-. An i(21q) was observed in two @entity1 , a -21 in four @entity1 and a -22, +t(21q22q) and a -5, -21, +t(5p21q) in one @entity1 each. Other @entity854 included @entity393 or rearrangements of the short arm of chromosome no. 17, observed in nine @entity1 . One @entity1 had a -12, three others had rearrangements resulting in a partial or @entity393 of the short arm of chromosome no. 12. A 19q+ with translocation to band 19q13 was observed in three cases, a -18 in three cases and a 3p- in four cases. Thirty-one @entity1 with multiple chromosome aberrations experienced a significantly shorter survival as compared to 13 @entity1 with a normal karyotype (P = 0.02) and 17 @entity1 with one single chromosome aberration (P less than 0.01).
