Palatal development and the XXXX cascade.

@entity230 @entity2871 @entity19 @entity1426 @entity3009 @entity3174 @entity35 @entity3352 @entity2419
The production of @entity2419 by glucocorticoids and @entity3174 is a complicated interference of a complex developmental program involving many genetic and biochemical processes. The H-2 histocompatibility region includes genes which affect susceptibility to glucocorticoid- and @entity3174 -induced @entity2419 ; glucocorticoid receptor level in a variety of tissues including @entity2419 , adult thymuses and lungs; and the degree of inhibition of @entity3009 and @entity2871 production by glucocorticoids and @entity3174 in thymocytes. A gene linked to a minor histocompatibility locus (H-3) on the second chromosome also influences susceptibility to glucocorticoid and @entity3174 -induced @entity2419 . @entity3174 is an alternate ligand for the glucocorticoid receptor affecting @entity3009 and/or @entity2871 production. The capacity of glucocorticoids to induce @entity2419 is correlated with their anti-inflammatory potency. At least some of the anti-inflammatory effects of glucocorticoids can be explained by the inhibition of @entity3009 and/or @entity2871 release, which in turn could be caused by inhibition of @entity1426 release from phospholipids. Similar mechanisms may be involved in @entity2419 induction, as exogenous @entity1426 injected into pregnant @entity35 and @entity19 at the same time as glucocorticoids reduces the teratogenic potency of the @entity230 and @entity3352 , and inhibitor of cyclooxygenase, blocks the corrective action of @entity1426 . Glucocorticoids and @entity3174 cause a delay in shelf elevation, and this delay is promoted by fetal membranes and the tongue. However, the cells of the medial edge epithelium are programmed to die whether contact is made with the apposing shelf or not. Glucocorticoids and @entity3174 interfere with this programmed cell death, and this interference by both drugs seems to be a glucocorticoid receptor mediated event, to require protein synthesis and to be related to @entity1426 release.
