XXXX ileal motor activity after a model of jejunoileal autotransplantation.

@entity235 @entity294 @entity409 @entity22780 @entity1718 @entity356 @entity1319 @entity2472
OBJECTIVE: To determine mechanisms by which extrinsic innervation to the jejunoileum controls ileal motility. SUMMARY BACKGROUND DATA: Small bowel transplantation is complicated by @entity294 and delayed @entity356 , possibly secondary to altered motility. @entity1319 after small bowel transplantation is poorly characterized. METHODS: Motor activity was recorded from four @entity235 during fasting and after feeding small (64 Kcal) or large (256 Kcal) meals. Short-chain @entity1718 known to induce unique ileal motor patterns were administered into the distal ileum during fasting. @entity235 were studied before and after jejunoileal denervation simulating autotransplantation. RESULTS: After jejunoileal denervation, the ileal migrating motor complex (MMC) persisted but was no longer temporally coordinated with duodenal MMCs. Spontaneous giant migrating @entity2472 occurred more frequently after denervation and more commonly originated proximally in the jejunum, but the velocity of migration did not differ. In contrast, the incidence and characteristics of spontaneous discrete clustered @entity2472 (DCCs) did not differ. @entity22780 reproducibly initiated giant migrating @entity2472 and discrete clustered @entity2472 in the distal ileum without differences before and after denervation. Large but not small meals inhibited the ileal MMC after denervation. CONCLUSIONS: Extrinsic innervation and/or intrinsic neural continuity with the duodenum and/or colon control temporal coordination of ileal motility with the duodenum and modulate postprandial inhibition of fasting motility and presence of giant migrating @entity2472 . These changes in motility patterns may prove important in mediating @entity409 after small bowel transplantation.
