XXXX as a modifier of the periodontal microbiome.

@entity1 @entity7278 @entity740 @entity2521 @entity454
BACKGROUND: Evidence supports high prevalence of @entity2521 in @entity1 with @entity740 . Several renal factors have been proposed as possible modifiers of @entity2521 pathogenesis in this population. In this cross sectional study, we investigated whether distinct microbial profiles in renal @entity1 could explain high @entity2521 prevalence. METHODS: We characterized the subgingival microbiome in 14 @entity454 ( @entity454 ) and 13 control individuals with @entity7278 with similar demographic and clinical parameters. Medical, demographic and periodontal parameters were recorded. Subgingival biofilm samples were collected from the deepest pocket in two different quadrants and characterized via 454-pyrosequencing of the 16S rRNA gene. RESULTS: We found 874 species-level operational taxonomic units (OTU) across samples. Renal and control groups did not differ in the individual proportions of @entity2521 -associated taxa. However, in principal coordinate plots of distance among samples based on OTU prevalence, some renal @entity1 clustered apart from controls, with the microbial communities of these outlier subjects showing less diversity. Univariate correlation analysis showed a significant negative correlation between dialysis vintage and community diversity. CONCLUSIONS: Within the study limitations, dialysis vintage was associated with a less diverse periodontal microbial community in @entity454 suggesting the need for further research.
