Benefit assessment of salt reduction in @entity1 with XXXX : systematic overview.

@entity1 @entity11559 @entity101 @entity13519 @entity177 @entity23 @entity204 @entity65
OBJECTIVE: We assessed the benefits and harm of reduced salt intake in @entity1 with essential @entity101 focusing on @entity1 -relevant outcomes and blood pressure. METHODS: A systematic search of five electronic databases was performed to identify high-quality secondary literature based on @entity23 ( @entity23 ). An update primary literature search ( @entity23 ) was performed for the time period up to 2010 that was not covered by secondary literature. Major outcomes were @entity204 , @entity65 /mortality, hospital stays, @entity177 , quality of life, and adverse events. Change in blood pressure was defined as surrogate parameter. RESULTS: Four different systematic reviews and two @entity23 met the inclusion criteria. Only one review reported limited data on @entity1 -relevant outcomes. Over an intervention period of up to 12 months, mean @entity13519 was reduced by 3.6-8.0 mmHg in all reviews. For the same intervention period, a statistically significant advantage with regard to mean @entity11559 reduction ranging from 1.9 to 2.8 mmHg was found in three reviews. The fourth publication reported a nonsignificant reduction ( @entity11559 reduction of 4.7 mmHg). None of the @entity23 identified in the primary literature search update reported data on @entity1 -relevant outcomes. However, both @entity23 found blood pressure improvements with salt reduction. CONCLUSION: A benefit from a salt-reduced diet in @entity1 with high blood pressure is not proven with regard to @entity1 -relevant outcomes based on systematic reviews and @entity23 published up to 2010. The results indicate a blood pressure-lowering effect through reduced salt intake in @entity101 @entity1 .
