Induction chemotherapy before operation for multiple XXXX .

@entity1 @entity7324 @entity41 @entity957 @entity900 @entity1138 @entity2415
BACKGROUND: @entity957 is sometimes difficult to resect due to poor pulmonary function. Although various therapeutic modalities are available, there is no consensus on the effectiveness of chemotherapy in such rare cases. In this study, we evaluated the efficacy of preoperative induction chemotherapy for @entity1 with otherwise unresectable @entity957 and poor pulmonary function. METHODS: Six @entity1 with @entity957 were enrolled in the study. They had a total of 15 foci that were in clinical stage I or II. Due to severe @entity2415 and poor pulmonary function, all 6 @entity1 were considered unsuitable for complete surgical excision if either bilateral thoracotomy or pneumonectomy was required. The @entity1 received two courses (at 3- to 4-week intervals) of induction chemotherapy, beginning on day 1 with @entity900 (80 mg/m2), @entity7324 (3 mg/m2), and @entity1138 (8 mg/m2). After induction chemotherapy, surgical resection was performed on all 6 @entity1 as bilateral thoracotomy and pneumonectomy were avoided due to the effectiveness of induction chemotherapy. RESULTS: Postoperative pathologic examination revealed a complete response in eight foci. Four nonresected foci have not recurred so far. Although three @entity41 were observed in resected specimens, they all showed moderate responses to chemotherapy. The possible complete response rate is 80%. All @entity1 have survived for 2 to 10 years without apparent recurrence. CONCLUSIONS: Induction chemotherapy can be added to treatment options for @entity1 with rare @entity957 that cannot be resected because of poor pulmonary function.
