Hormonal control of haemostasis during hypoglycaemia in XXXX .

@entity2801 @entity1 @entity3548 @entity455 @entity6 @entity2880 @entity1425 @entity3880 @entity8325 @entity2881 @entity413
@entity2801 ( @entity2801 ) and plasminogen activator activity ( @entity3880 ) rise during hypoglycaemia, and this might contribute to the @entity455 of @entity6 . Similar changes in haemostasis accompany raised plasma levels of vasopressin (aVP) and adrenaline. To investigate the effects of these hormones on haemostasis during hypoglycaemia and the role of plasma insulin concentrations, eight insulin-dependent @entity6 @entity1 underwent controlled hypoglycaemia for 20 min and 13 @entity6 @entity1 were investigated during hyperinsulinaemia with blood @entity413 maintained at 8.0 mmol/l. During hypoglycaemia, insulin levels increased to median values of 114 mU/l, a @entity3548 rose from 0.5 to 4.4 (p less than 0.005) pg/ml and @entity1425 from 0.4 to 4.4 nmol/l (p less than 0.005). @entity2801 coagulant activity ( @entity2801 :C) rose from 0.75 to 1.09 IU/ml (p less than 0.01) and the @entity8325 co-factor (FVIIIR:Co) and @entity2880 factor antigen ( @entity2881 :Ag) showed similar responses. @entity3880 increased from 156 to 745 units (p less than 0.005). During hyperinsulinaemia, insulin rose following infusion from 24 to 52 and 118 mU/l, maintained for an hour at each level. Despite this, plasma aVP, @entity2801 :C, FVIIIR:Co, @entity2881 :Ag and @entity3880 remained unchanged. This study indicates that the marked changes in @entity2801 , @entity2881 and @entity3880 concentrations which accompany hypoglycaemia depend on low blood @entity413 and not raised plasma insulin. The response in probably mediated by increases in adrenaline and aVP, which are part of the physiological response to hypoglycaemia.
