Biological behavior and cell properties of new AKR XXXX variants.

@entity1 @entity1619 @entity706 @entity5 @entity405
The AKR @entity706 is a T lymphocyte @entity5 , most suitable as a model for @entity1 T cell @entity5 . We have been interested in the process of @entity5 progression in the @entity706 system. In the present study, two newly isolated variants, the TAU-42 and TAU-44, were characterized with respect to their biological behavior, by comparing them to a previously studied low-malignancy variant, the TAU-39. While the TAU-44 variant formed large s.c. local @entity5 , the TAU-42 variant formed only small growths or none at all. The TAU-42 @entity706 was found to have the highest malignant potential: it displayed very marked dissemination to spleen, lymph nodes, liver and lungs. The TAU-44 variant had an intermediate degree of metastatic potential but presented a predilection for spread to lymph nodes and spleen and was sometimes found to metastasize to peculiar organs, such as heart and pancreas. Cells derived from the @entity706 variants varied in their immunophenotype: the highly malignant variant cells expressed more CD4 antigen than the low-malignancy one. The opposite was observed with regard to @entity405 . The variant cells also differed in their migrating capacity, the more malignant one exhibiting a higher motile activity. Studies on the @entity5 progression model of @entity706 might contribute to the elucidation of the features determining the aggressiveness of @entity1619 .
