Quantification of brain gray matter damage in different XXXX phenotypes by use of diffusion tensor MR imaging.

@entity1 @entity15
BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from @entity1 with @entity15 ( @entity15 ) is not spared. This study was performed to quantify in vivo the extent of cerebral GM pathologic abnormality in @entity1 with relapsing-remitting (RR), secondary progressive (SP), and primary progressive @entity15 , by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo and DT MR imaging of the brain were performed in 102 @entity1 with @entity15 and 30 healthy volunteers. After GM segmentation using a technique based on diffusion anisotropy thresholding, average diffusivity (D) histograms of the cerebral GM were produced for all @entity1 . RESULTS: All D histogram-derived metrics of the GM were significantly different between control volunteers and the whole @entity15 population. No significant difference was found for any of the D histogram-derived metrics between control volunteers and @entity1 with RRMS, whereas significant differences were found for D and D histogram peak location between control volunteers and @entity1 with PPMS. All the D histogram-derived metrics differed significantly between @entity1 with RRMS and @entity1 with SPMS. @entity1 with SPMS also had significantly lower D than did @entity1 with PPMS. All D histogram-derived metrics of the GM were strongly correlated with the T2 lesion volume. CONCLUSIONS: This study confirms the presence of brain GM changes in @entity1 with @entity15 . It also shows that the extent of such changes is greater during the progressive forms of the disease.
