Controlled, comparative study of @entity3399 and XXXX for prophylaxis of abdominal hysterectomy.

@entity1 @entity7048 @entity114 @entity5898 @entity281 @entity3399
@entity3399 was compared with @entity7048 and a control group to determine the efficacy and value of a third generation @entity5898 in abdominal hysterectomy antibiotic prophylaxis. One hundred @entity1 were prospectively randomized in a double-blind manner between @entity3399 and @entity7048 . An additional 50 @entity1 who were either allergic to @entity114 or refused participation in this study were simultaneously observed to establish a base line level of @entity281 on our service during this time period. Dosage for both antibiotic groups was 1 gram given intravenously or intramuscularly on call to the operating room followed by two 1 gram doses at six and 12 hours after the first dose. Standard febrile morbidity was 36, 30 and 42 per cent for @entity3399 , @entity7048 and control groups, respectively. Postoperative surgical @entity281 requiring antibiotic treatment occurred in 8, 6 and 4 per cent, respectively; urinary tract @entity281 or symptomatic findings, or both, requiring treatment occurred in 8, 10 and 10 per cent, respectively. No pelvic abscesses occurred in this series. In every statistical evaluation of postoperative morbidity, there were no differences noted among the three groups. Our results suggest no benefit from the use of prophylactic antibiotics in abdominal hysterectomy in terms of standard febrile or infectious morbidity or urinary tract pathologic findings. In addition, there was no difference between the two antibiotic groups.
