Relationship between expression of @entity4634 and @entity14797 on XXXX and the antitumor effects of @entity405 + T cells.

@entity1 @entity4634 @entity5 @entity1721 @entity8395 @entity405 @entity14797
UNASSIGNED: The programmed death-1 (PD-1)/programmed death-ligands (PD-Ls) signal pathway has been implicated as a potential immune escape mechanism in several @entity1 @entity5 . However, the studies of @entity8395  -Ls pathway in @entity1721  (ECSS) are not yet sufficient. The current study investigated the expression of @entity4634 , @entity14797 and PD  -1 in ESCC tissues. The correlations between the expression of these proteins and clinical histopathological parameters were analyzed. Then the stable transfected Ec109 cell lines overexpressing @entity4634 / @entity14797 were established by plasmid transfection successfully. Ec109 and @entity405 + T  cells were co  -cultured to analyze the effects of @entity8395  -Ls signal pathway on the function of @entity405 + T  cells including proliferation, apoptosis and interferon  -y production. We found that @entity4634 -positive @entity1 had significantly poorer prognosis than the negative @entity1 , while their prognosis was not related to @entity14797 expression. The count of PD  -1+ TILs  ( @entity5  -infiltrating lymphocytes) was negatively correlated with both @entity4634 and @entity14797 expression. In functional studies, we found that @entity8395  -Ls signal pathway was able to downregulate the function of @entity405 + T  lymphocyte and its function could be restored by blocking the signal pathway. This indicates that @entity8395  -Ls may prevent effective antitumor immunity, which provides important evidence to delineate the cellular immune deficiency mechanism in ESCC. Therefore, @entity8395 are predicted to become novel targets for ESCC immunotherapy.
