Surgical Outcomes of High-Grade Spinal XXXX .

@entity1 @entity5 @entity602 @entity11 @entity463
STUDY DESIGN: A retrospective study. PURPOSE: The purpose of this study was to obtain useful information for establishing the guidelines for treating high-grade spinal @entity11 . OVERVIEW OF LITERATURE: The optimal management of high-grade spinal @entity11 remains controversial. We report the outcomes of the surgical management of 14 high-grade spinal @entity11 . METHODS: We analyzed the outcomes of 14 @entity1 with high-grade spinal @entity11 who were surgically treated between 1989 and 2012. Survival was charted with the Kaplan-Meier plots and comparisons were made with the log-rank test. RESULTS: None of the @entity1 with high-grade spinal @entity11 underwent total resection. Subtotal resection was performed in two @entity1 , partial resection was performed in nine @entity1 , and open biopsy was performed in three @entity1 . All @entity1 underwent postoperative radiotherapy and six @entity1 further underwent radiation cordotomy. The median survival time for @entity1 with high-grade spinal @entity11 was 15 months, with a 5-year survival rate of 22.2%. The median survival time for @entity1 with World Health Organization grade III @entity5 was 25.5 months, whereas the median survival time for @entity1 with @entity463 multiforme was 12.5 months. Both univariate and multivariate Cox proportional hazards models demonstrated a significant effect only in the group that did not include cervical @entity602 as a factor associated with survival (p=0.04 and 0.03). CONCLUSIONS: The surgical outcome of @entity1 diagnosed with high-grade spinal @entity11 remains poor. Notably, only the model which excluded cervical @entity602 as a factor significantly predicted survival.
