@entity2242 -regulated CCAAT/enhancer-binding proteins b and    are essential in Fcy receptor-mediated XXXX cytokine and chemokine production in macrophages.

@entity32 @entity310 @entity2242 @entity10149 @entity9322 @entity6863 @entity10557 @entity1366
CCAAT/enhancer-binding protein b @entity9322 ) and @entity6863   are known to participate in the regulation of many genes associated with @entity32 . However, little is known about the activation and function of @entity9322 and -   in @entity32 responses elicited by Fcy receptor (FcyR) activation. Here we show that @entity9322 and -   activation are induced in IgG immune complex (IC)-treated macrophages. The increased expression of @entity9322 and -   occurred at both mRNA and protein levels. Furthermore, induction of @entity9322 and -   was mediated, to a large extent, by activating FcyRs. Using siRNA-mediated knockdown as well as macrophages deficient for @entity9322 and/or -  , we demonstrate that @entity9322 and -   play a critical role in the production of @entity310 , @entity10149 , and @entity10557 in IgG IC-stimulated macrophages. Moreover, both @entity1366 and p38 MAPK are involved in @entity6863 induction and @entity310 , @entity10149 , and @entity10557 production induced by IgG IC. We provide the evidence that @entity2242 regulates IgG IC-induced @entity32 responses by enhancing @entity1366 and p38 MAPK activities as well as @entity9322 and -   activities. Collectively, these data suggest that @entity9322 and -   are key regulators for FcyR-mediated induction of cytokines and chemokines in macrophages. Furthermore, C/EBPs may play an important regulatory role in IC-associated @entity32 responses.
