Endothelial microRNA-150 is an intrinsic suppressor of pathologic XXXX .

@entity32366 @entity2194 @entity1940 @entity2479 @entity19 @entity4222 @entity26 @entity9843 @entity1939 @entity38408 @entity989 @entity16110 @entity5237
@entity16110 commonly causes @entity1939 . It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics. MicroRNAs regulate both physiological and pathological angiogenesis through modulating expression of gene targets at the posttranscriptional level. However, it is not completely understood if specific microRNAs are altered in pathologic ocular blood vessels, influencing @entity2194 . Here we investigated the potential role of a specific microRNA, @entity38408 , in regulating @entity2194 . We found that @entity38408 was highly expressed in normal quiescent retinal blood vessels and significantly suppressed in pathologic neovessels in a @entity19 model of @entity26 -induced @entity989 . @entity38408 substantially decreased endothelial cell function including cell proliferation, @entity4222 , and tubular formation and specifically suppressed the expression of multiple angiogenic regulators, @entity9843 , @entity5237 , and @entity32366 , in endothelial cells. Intravitreal injection of @entity38408 mimic significantly decreased pathologic @entity2479 in vivo in both wild-type and @entity38408 knockout @entity19 . Loss of @entity38408 significantly promoted angiogenesis in aortic rings and choroidal explants ex vivo and laser-induced @entity1940 in vivo. In conclusion, @entity38408 is specifically enriched in quiescent normal vessels and functions as an endothelium-specific endogenous inhibitor of pathologic @entity2194 .
