Decreased XXXX -glycoprotein-induced lymphocyte proliferation in vitro in @entity5930 .

@entity1 @entity286 @entity650 @entity5930 @entity79 @entity1192 @entity1199
@entity5930 is a disorder caused by localized collections of proliferating histiocytes in the lung. Little is known about its etiology except that the majority (58 to 97%) of @entity1 are current or ex-smokers, making the potential etiologic role of @entity286 products an important area for research. @entity286 glycoprotein (TGP) is a potent immunostimulator that has been isolated from cigarette smoke. TGP-specific lymphocyte proliferation, and cytokine production in vitro, were measured in three @entity1 with @entity5930 in remission and in three closely matched normal subjects with similar smoking histories. One @entity1 with @entity79 and a matched control subject were also studied. Peripheral blood mononuclear cells were cultured with TGP, the recall antigen streptokinase (SK), and the mitogen concanavalin A (Con A). All three of the @entity1 with @entity5930 exhibited significant decreases in lymphocyte stimulation to TGP, despite normal responses to SK and Con A. In contrast, the response of the @entity1 with @entity79 was higher than her matched control. The mean responses of the @entity1 with @entity5930 to TGP was significantly lower than the mean of nondiseased smokers or of normal nonsmokers. Twenty-four-hour culture supernatants were collected and assayed for cytokine levels ( @entity1192 , @entity1199 , and @entity650 ). TGP-stimulated @entity1199 production was significantly lower in the @entity1 with @entity5930 than in the normal subjects, confirming the reduced T-cell proliferative response.(ABSTRACT TRUNCATED AT 250 WORDS)
