Relationship between @entity9667 Genetic Polymorphism and Essential XXXX in a Chinese Population.

@entity1 @entity101 @entity9667 @entity8107 @entity71599 @entity71601 @entity71600 @entity71598 @entity71597
UNASSIGNED: The relationship between @entity9667 genetic polymorphisms and essential @entity101 (EH) remains unclear. The aim of this study was to investigate the association of @entity9667 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 @entity1 (270 EH @entity1 and 288 controls) and a Uighur population including 473 @entity1 (181 EH @entity1 and 292 controls) were selected. Five single-nucleotide polymorphisms (SNPs) ( @entity71597 , @entity71598 , @entity71599 , @entity71600 , and @entity71601 ) were genotyped using real-time PCR (TaqMan). In the Uighur population, for the total and the @entity1 , @entity71597 , @entity71599 and @entity71600 were found to be associated with EH ( @entity71597 : P <=0.02, @entity71599 : P <=0.002, @entity71600 : P <=0.004, respectively). The difference remained statistically significant after the multivariate adjustment (all P<0.05). The overall distributions of the haplotypes established by @entity8107 -SNP3, @entity8107 -SNP4, @entity8107 -SNP3-SNP5 and @entity8107 -SNP4-SNP5 were significantly different between the EH @entity1 and the control subjects (for the total: P=0.013, P=0.008, P=0.032, P=0.010, for @entity1 : P<0.001, P=0.001, P=0.010, P=0.00). In the Han population, for @entity1 , @entity71601 was found to be associated with EH in a recessive model (P=0.007); the significant difference was not retained after the adjustment for the covariates (date not shown). The A allele of @entity71597 could be a susceptible genetic marker, and the T allele of @entity71600 could be a protective genetic marker of EH. The AC genotype of @entity71597 , the AG genotype of @entity71599 and the TT genotype of @entity71600 could be protective genetic markers of EH.
