Evaluation of pulmonary nodules and XXXX on chest CT with radiation dose equivalent to chest radiography: Prospective intra-individual comparison study to standard dose CT.

@entity1 @entity281 @entity11721 @entity358
PURPOSE: To compare prospectively, in @entity1 undergoing chest computed tomography (CT) for pulmonary-nodules or @entity281 , image-quality and accuracy of standard dose (SD) and reduced dose (RD) CT with @entity11721 -filtration. MATERIAL AND METHODS: This IRB-approved study included 100 consecutive @entity1 (36 female;median age 56 years) referred for follow-up of pulmonary-nodules (n=43) or suspicion of @entity281 (n=57) undergoing single-energy CT with SD and RD using tin-filtration at 100kVp (CTDIvol 2.47mGy and 0.07mGy, respectively). Images were reconstructed with advanced modeled iterative reconstruction (ADMIRE) at strength 3 and 5. Image-noise was measured. Two independent readers evaluated nodules and @entity358 . SD CT served as reference standard. RESULTS: No significant difference was found in noise between RD with ADMIRE5 and SD with ADMIRE3 (118HU  14 vs. 120HU  17; p=0.08). Sensitivity for detection of atelectasis and interstitial lung changes was higher in images reconstructed with ADMIRE5 (93% and 88%; respectively) than in those reconstructed with ADIMRE3 (77% and 78%; respectively). Sensitivity for detection of consolidations was 90% for ADMIRE3 and 89% for ADMIRE5. Sensitivity for nodule detection was 71% for ADMIRE3 and 81% for ADMIRE5. Specificity for detection of atelectasis and interstitial lung changes was 99% and 96% with ADMIRE5 and 99% and 96% with ADMIRE3. Specificity for detection of consolidations was 99% for ADMIRE3 and 5. Specificity for detection of nodules was 87% for both ADMIRE3 and 5. CONCLUSION: Chest CT with a radiation dose equivalent to conventional radiography is feasible and allows for detection of @entity358 with high sensitivity, whereas the accuracy for detecting nodules is only moderate.
