Reliability of magnetic resonance imaging performed after intratympanic administration of XXXX in the identification of endolymphatic hydrops in @entity1 with @entity195 .

@entity1 @entity2288 @entity601 @entity74 @entity195 @entity2287
OBJECTIVE: To evaluate the reliability of magnetic resonance imaging performed after intratympanic @entity2287 administration in evidencing endolymphatic hydrops in @entity1 with @entity195 ( @entity601 ). @entity1 : A total of 26 @entity1 (18 male and 8 female subjects, aged 25-78 yr; median age, 56 yr) with definite @entity601 and 12 subjects (8 male and 4 female subjects, aged 31-75 yr; median age, 51 yr) with various unilateral @entity74 of the inner ear were examined. INTERVENTION: A 0.6-ml solution of @entity2288 (1 mmol/ml), diluted 1:7 in saline, was injected in the affected ear through the inferior-posterior quadrant of the tympanic membrane, using a 22-gauge spinal needle. In 9 @entity601 @entity1 , the contralateral ear also was injected. The @entity1 was kept with the head rotated 45 degrees contralaterally for 30 minutes after each injection. Twenty-four hours later, a 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging using a 3 Tesla unit was performed. MAIN OUTCOME MEASURE: Perilymphatic enhancement was evaluated in different portions of the labyrinth in @entity601 ears and compared with the outcomes obtained in the non- @entity601 ears. RESULTS: All @entity601 ears showed impaired perilymphatic enhancement of variable degrees. No enhancement defects could be observed in all examined contralateral unaffected ear of the @entity1 with @entity601 , as well as in 11 of the 12 ears of the subjects with various unilateral @entity74 . CONCLUSION: Perilymphatic enhancement defect of variable degrees is observed in the pathologic ear of every @entity1 with @entity601 . The consistency of this phenomenon in @entity601 ears and the complete enhancement in most of the ears without @entity601 safely enable to attribute these findings to endolymphatic hydrops. It is likely in the near future that imaging may be used to achieve a certain diagnosis of @entity601 in life.
