XXXX : pathologic spectrum and clinical implications.

@entity1 @entity353 @entity548 @entity66 @entity5 @entity189 @entity3546 @entity490 @entity14 @entity3 @entity2513 @entity204 @entity1744
@entity14 is an uncommon entity with ill-defined clinicopathologic characteristics. We describe the clinicopathology of 23 new cases and review 67 previously reported cases. Clinically, @entity1 (mean age, 61.9 y; male: female, 1.0:1.1) presented with a positive fecal occult blood test or visible @entity548 (44%), @entity490 or change in bowel movement pattern (25%), @entity1744 (19%), or @entity353 (19%). Endoscopically, the @entity5 presented as a polypoid lesion (57%), a @entity66 (30%), or an ulcerating lesion (9%). @entity5 were located in the right colon (56%), transverse colon (3%), and left colon (41%). Surgical resection was the treatment of choice in 83% of cases. After follow-up for an average of 20 months, the @entity5 -related @entity204 rate was 68%. Histologically, 42% were classified as composite @entity5 and 58% were classified as collision @entity5 . An @entity2513 , and then @entity189 to @entity5 progression through the APC/ @entity3546 pathway was seen in a majority of cases. Both the glandular and the neuroendocrine components of the @entity5 can show a spectrum of differentiation, and each component can @entity3 separately regardless of its percentage volume. On the basis of the combined analysis of the pathologic spectrum and the clinical behavior of our series and previously reported cases, we propose a new classification system that reflects the differentiation of each component in @entity14 to facilitate uniform reporting and to better predict its clinical behavior.
