HYPERCALCEMIA AND METASTATIC MINERALIZATION INVOLVING FOOTPADS IN ROCK HYRAXES ( XXXX ).

@entity32 @entity8 @entity1273 @entity2741 @entity48237 @entity2629 @entity460 @entity1986 @entity1663
Three rock hyraxes ( @entity48237 ) maintained in a zoological collection had chronic @entity2741 and @entity2629 . In addition, all animals displayed signs of @entity1273 due to footpad lesions that were histologically characterized as marked metastatic mineralization with @entity32 , reminiscent of @entity1663 . Although the animals were managed with aggressive fluid therapy, calciuresis, and dietary modification, all were eventually humanely euthanized due to the severity of their footpad lesions and/or progression of @entity8 . Metastatic mineralization was also noted in other soft tissues among the three cases, including the stomach, colon, lung, vascular wall, ovary, and kidney. Varying degrees of @entity1986 were confirmed on postmortem examination, and in the absence of other causes for @entity2741 , metastatic mineralization was presumably the consequence @entity8 . The renal pathway is the primary mode of @entity460 excretion in the @entity48237 . In @entity8 , @entity2741 may develop secondary to decreased @entity460 excretion. Footpad mineralization is an uncommon sequel to @entity8 in domestic animals but has not been reported in rock hyraxes. A retrospective review of mortality data in this collection revealed a notable prevalence of @entity8 , including two additional animals with metastatic mineralization and @entity8 . Expanding knowledge of @entity8 will further guide preventative and clinical measures, including screening for metastatic mineralization and therapeutic trials for management of @entity2741 and @entity460 mineral deposition in the footpads and other soft tissues.
