XXXX Mutilans: Clinical and Radiographic Criteria. A Systematic Review.

@entity1 @entity66 @entity3947 @entity5144 @entity4932 @entity2720
OBJECTIVE: Research on @entity5144 mutilans (PAM), the most severe form of @entity5144 , is impeded by the lack of an accepted classification criteria. We performed a systematic review of the literature to identify and synthesize clinical and radiographic features associated with the definition of PAM. METHODS: A systematic literature search limited to @entity1 studies was conducted without language restriction. Abstracts were independently screened by 2 investigators and studies that reported information on @entity1 with PAM were included. A standardized form was used to independently collect clinical and radiographic items defining PAM, @entity1 's demographics, disease characteristics, and outcomes. RESULTS: There were 8570 citations searched to identify 112 articles for full review and 58 articles for data abstraction. We identified 8 definitions of PAM that were used in 283 subjects with a mean age    SD at diagnosis of PsA of 33.9    8.2 years. Disease manifestations (prevalence) included dactylitis (29-64%), @entity4932 (29-32%), @entity66 (14-27%), and nail lesions (47%). PAM definitions include 1 (n = 2 studies) or more (n = 14 studies) joints involving interphalangeal, metacarpophalangeal, or @entity2720 . The most prevalent PAM clinical features were digital telescoping (34%), digital shortening (33%), and @entity2720 (22%). The most prevalent PAM radiographic items were bone resorption (41%), pencil-in-cup change (16%), @entity2720 (14%), @entity3947 (21%), and subluxation (7%). CONCLUSION: We have identified 8 definitions of PAM, and synthesized the clinical and radiographic items that are important for the classification of PAM. We have established the groundwork for future development classification criteria for PAM.
