[Impact of visit-to-visit blood pressure variability on vascular function in elderly @entity101 XXXX ].

@entity1 @entity4631 @entity101 @entity1242 @entity450 @entity15882
OBJECTIVE: To assess the relationship between visit-to-visit blood pressure (BP) variability ( @entity15882 ) and vascular endothelial function in a cohort of elderly @entity101 @entity1 . METHODS: A total of 174 elderly @entity1 with essential @entity101 were included in the study. The @entity1 had their office BP measured during the 12-month follow-up. Right brachial artery diameter was assessed at rest, during reactive @entity450 (flow-mediated dilation, @entity4631 ), and after @entity1242 administration ( @entity1242 -mediated dilation, NMD). The @entity1 were divided into two groups according to @entity4631 % or @entity4631 /NMD ratio. The correlations between @entity15882 and endothelial function were analyzed by univariate analysis and multiple linear regression analysis. RESULTS: The @entity1 classified as having a decreased endothelial function according to @entity4631 /NMD ratio had significantly lower @entity4631 % and higher @entity15882 and NMD% (P<0.05). The percentage of CCBs use in normal endothelial function group was significantly higher than that in decreased endothelial function group (79.55% vs 63.95%, P<0.05). Multiple linear regression analysis revealed a significant negative association between @entity4631 /NMD ratio and @entity15882 , and this association remained significant after adjustment for age, body mass index, and mean BP levels. CONCLUSIONS: @entity4631 /NMD ratio is a better marker of endothelial function than @entity4631 , and an increased visit-to-visit variability of BP is associated with a decreased endothelial function.
