Potential genotoxicity and risk assessment of a chlorinated flame retardant, XXXX .

@entity21384 @entity137 @entity14825
UNASSIGNED: @entity21384 (DP) is a chlorinated flame retardants that is globally ubiquitous. It is a potentially persistent organic pollutant (POPs) and an environmental toxin. However, the @entity137 data is still limited and cannot provide a comprehensive environmental ecological risk assessment for DP. In this study, luminous bacteria, Vicia faba and @entity14825 were chosen as testing organisms to investigate the acute @entity137 and mutagenicity of DP. The concentration gradient of DP used in this study was chosen based on its environmental levels (experiments of luminous bacteria: 0.591, 2.95, 14.8, 73.8, 369 gL(-1); micronucleus tests: 2.4, 12, 60, 300, 1500 gL(-1); comet assay: 2.4, 12, 60, 300, 1500 gL(-1)). For luminous bacteria, the relative luminosities were around 100% in treated groups, which suggested that there is no acute @entity137 to luminous bacteria under the studied DP concentrations. The micronucleus test showed no significant difference between treatment and control groups, indicating no genotoxicity of DP. However the comet assay conducted with @entity14825 was relatively sensitive as there was a significant increase in DNA damage when the concentrations of DP increased from 300 to 1500 gL(-1), while the lower concentrations failed to show any treatment-related differences. Therefore, DP may pose a potential risk at concentration   300 gL(-1). The results provide scientific information on the ecological risk assessment of DP.
