Airway stenting and tracheobronchoplasty improve respiratory symptoms in XXXX .

@entity1 @entity37796 @entity10485 @entity194 @entity4595 @entity401 @entity204
BACKGROUND: @entity37796 ( @entity37796 ) is a condition characterized by @entity37796 resulting from the loss or @entity194 of musculoelastic fibers within the airway wall. Concomitant @entity10485 is seen in most @entity1 with @entity37796 , often leading to significant respiratory compromise due to @entity4595 , increased dead space, and impaired secretion clearance. METHODS: We report a series of 12 @entity1 with @entity37796 and @entity10485 who were evaluated at our institution for significant respiratory problems. Stent trials were conducted in 10 @entity1 , with seven proceeding to operative tracheobronchoplasty (TBP) and one continuing with long-term stent placement. One @entity1 underwent TBP without prior stent placement. Of the remaining three @entity1 , two had no improvement with trials of stent placement, and a stent could not be placed in the third because of a large tracheal diameter. RESULTS: Compared with baseline values, clinically significant improvements in health-related quality-of-life measures and pulmonary function testing were seen in @entity1 who underwent central airway stabilization (n = 9). Complications of both stent placement and TBP were generally mild. However, one @entity204 was reported in the surgical group secondary to an exacerbation of preexisting @entity401 . CONCLUSIONS: An aggressive approach that targets central airway stabilization may improve outcomes for @entity1 with @entity37796 . TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00550602; URL: www.clinicaltrials.gov.
