Survivin expression and targeting in XXXX .

@entity1 @entity2289 @entity0 @entity7 @entity5 @entity470 @entity7895 @entity2290 @entity1722
INTRODUCTION: Survivin a multifunctional protein that controls cell division, inhibition of apoptosis and promotion of angiogenesis. It is expressed in most @entity1 @entity5 , but is absent in normal and differentiated tissues. The purpose of this article is to overview the expression of survivin, effect of its expression in response to treatment, correlation with other markers and newer advancement in targeting survivin. METHODS: A detailed search of Medline was carried out using the following search strategy: "((survivin) OR ((apoptosis) AND (inhibitor OR inhibitors))) AND ((breast) AND ( @entity5 OR @entity5 ))". Abstract of all articles thus identified were reviewed to identify the relevant studies, full articles of studies thus identified were then obtained and reviewed. All relevant data was extracted and tabulated. RESULTS: Survivin expression by Immunohistochemistry was identified in 65.3% (55.2-90.0%) of the @entity0 @entity1 among the identified studies while survivin mRNA by RT-PCR was identified in 93.6% (90-97%). Survivin expression has been reported to be associated with over expression of @entity1722 , @entity7 ( @entity7 ), @entity2290 ( @entity2290 )/ @entity2289 . CONCLUSION: Survivin is over expressed in majority of @entity0 . The over expression of survivin is found to correlate with @entity1722 and @entity470 expression. Survivin expression has been found to confer resistance to chemotherapy and radiation. Targeting survivin in experimental models improves survival. More studies are needed on the role of survivin in multi drug resistance (MDR) in the presence of @entity7895 / @entity2290 / @entity2289 and the impact of survivin over expression in triple negative @entity0 .
