Efficacy of mesenchymal stem cells injection for the management of XXXX : a systematic review and meta-analysis.

@entity1 @entity626 @entity353 @entity571 @entity158
OBJECTIVE: The purpose of this study was to access the efficacy of mesenchymal stem cells (MSCs) injection in the treatment of @entity626 ( @entity571 ). METHODS: Studies were identified from databases (Pubmed, Embase, Cochrane Library, Biosis Previews, ClincalTrials.gov, CBMdisc) searched to December 2014 using a battery of keywords. We included randomized controlled and controlled clinical trials of @entity1 with knee @entity571 comparing the outcomes of @entity158 and function for those receiving MSCs injection with those receiving no MSCs injection. Two reviewers independently selected studies, extracted relevant data and assessed study quality. Data were pooled and meta-analyses were performed. RESULTS: Seven randomized controlled and controlled clinical trials, studying a total of 314 @entity1 with a diagnosis of knee @entity571 were included. Overall, MSCs injection has no significant effect on @entity158 [ @entity353 ( @entity353 ) (95 % confidence interval (CI)) [-1.33(-3.08, 0.41), P = 0.13], and tends to improve self-reported physical function [standardized mean difference (SMD) (CI) = 2.35(0.92, 3.77), P = 0.001] at the last follow-up. But results from two high quality trials (94 @entity1 ) show a positive effect of MSCs injection on @entity158 [ @entity353 (CI)   =   -0.49 (-0.79, -0.19), P = 0.001]. Heterogeneity observed between studies regarding the effect of MSCs injection on @entity158 and function was explained by the difference of follow-up time, outcome measures, control group, the source and dose of MSCs. The quality of evidence supporting these effect estimates was rated as low. CONCLUSION: MSCs injection could be potentially efficacious for decreasing @entity158 and may improve physical function in @entity1 with knee @entity571 . The findings of this review should be confirmed using methodologically rigorous and adequately powered clinical trials.
