The Prognostic Value of the XXXX 's Nodal Status after Surgery for Colorectal Liver Metastases in the @entity7971 of Effective Systemic Therapy.

@entity1 @entity7971 @entity5 @entity14 @entity694
BACKGROUND: The nodal status of primary @entity14 is of prognostic value for survival after the resection for colorectal liver metastases (CRLM). However, in the past decade, effective adjuvant chemotherapy for lymph node positive primary @entity694 was introduced. This study evaluated the prognostic value of primary lymph node status in @entity1 with resectable metachronous CRLM in the @entity7971 of effective systemic therapy. METHODS: Between January 2000 and December 2011, all consecutive @entity1 undergoing curative liver resection for CRLM were retrospectively analyzed. Overall survival (OS) was analyzed by the localization of the @entity5 (colon vs. rectum) and by lymph node status (positive vs. negative) of the @entity5 . RESULTS: A total of 286 @entity1 with metachronous CRLM's were selected. Five-year OS was similar for colon and rectal primaries (42 and 40%, p = 0.62). Lymph node positivity was only a prognostic factor in rectal primaries (N+ 32% vs. N0 49%, p = 0.04) and not in colon primaries (N+ 42% vs. N0 41%, p = 0.99). In multivariate analysis, these results were confirmed. CONCLUSION: The current study demonstrates that the nodal status of primary @entity694 does not have prognostic value in @entity1 undergoing resection for metachronous CRLM. A possible explanation might be the administration of effective adjuvant chemotherapy in node positive @entity694 .    2015 S. Karger AG, Basel.
