Renal pathology at autopsy in XXXX who died after hematopoietic stem cell transplantation.

@entity1 @entity9818 @entity8 @entity82 @entity9538 @entity2132 @entity194 @entity810 @entity5501
@entity810 are common after hematopoietic stem cell transplantation (HSCT). Although the pathology of chronic @entity8 is well described, the histologic changes that accompany acute @entity8 after HSCT are less well known because renal biopsies are rarely undertaken in the peritransplantation period. Archival renal tissue from consecutive HSCT recipients who died and underwent autopsy at a single center during an 8-year period was studied. Abnormalities of renal pathology were described, and associations of histologic abnormalities with clinical events were systemically studied. Abnormalities of renal histology were common among the 26 @entity1 in this study. The 3 most common histologic abnormalities were @entity8 (19/26; 73%), tubular epithelial atypia (19/26; 73%), and tubular calcification (18/26; 69%). @entity9538 (16/24; 67%) and @entity82 (16/26; 62%) were also frequently observed. Clinical @entity5501 was not associated with histologic evidence of @entity9818 in the kidney at autopsy. Also, clinical @entity2132 was not associated with @entity8 . Unexpectedly, the proportion of @entity1 with tubular @entity194 (54%) or @entity82 (62%) was high, considering the young age of the @entity1 at transplantation and their normal pretransplantation creatinine clearance. Well-recognized histologic abnormalities are common in the kidneys of @entity1 who die after HSCT. Although we did not demonstrate associations of these histologic changes with clinical variables before death, larger studies with prospectively collected renal tissue are warranted.
