XXXX : correlation of histologic grade, Ki67 and @entity876 expression with @entity1 survival.

@entity1 @entity66 @entity1313 @entity5 @entity11 @entity876 @entity1758
BACKGROUND: @entity11 are grouped into grades 1 to 4 on the basis of morphologic criteria. Grade is the most significant prognostic factor determining survival, but various proliferation markers are being increasingly employed by histopathologists as adjuncts to conventional morphologic variables to determine prognostic behavior of @entity1313 . The most widely used and useful of these are @entity1758 (Ki67) and @entity876 . OBJECTIVE: To correlate World Health Organization (WHO) grades of @entity66 and expression of @entity1758 and @entity876 by these @entity5 with @entity1 survival at the end of one year. MATERIAL AND METHODS: 50 consecutive cases with confirmed diagnosis of various histologic types of @entity66 were included. Grading was done according to the WHO grading system for CNS @entity5 . Immunohistochemical staining of @entity876 and @entity1758 (Ki67) was performed and scores were calculated. RESULTS: A significant correlation was shown between WHO histologic grade and @entity1 survival (p value:0.004) and a marginal correlation was seen between @entity1758 score and @entity1 survival (p value: 0.233). CONCLUSION: Histologic grade is the most important prognostic factor with respect to @entity1 survival in @entity66 . Immunohistochemical staining with @entity1758 and @entity876 may serve as an additional useful toolin determining the clinical course in combination with and as an adjunct to @entity5 grade. However, the fact that follow-up was available in only twenty out of the fifty cases is a limitation of the present study.
