Long-term effects of @entity353 on pharmaceutical costs in XXXX subjects. A report from the SOS intervention study.

@entity1 @entity353 @entity28 @entity6 @entity65
BACKGROUND: Although intentional weight reduction improves obesity-related comorbidities, the associations between weight reduction, medication and related costs are rarely studied. This study investigates the long-term effects of weight change on medication for @entity6 and @entity65 ( @entity65 ) in severely @entity28 subjects. METHODS: In the intervention study Swedish Obese Subjects, 510 surgically and 455 conventionally treated @entity28 @entity1 have so far been followed for 6 y. Changes in the use and costs of medication were analyzed in relation to treatment and weight change. RESULTS: In comparison with controls, larger fraction of surgically treated @entity1 discontinued the use of medication for @entity65 and @entity6 at 2 and 6 y (risk ratios 0.56-0.77). Among subjects not initially on medication, surgery reduced the frequency of started treatments (risk ratios 0.08-0.80). Relative @entity353 >or=10% was necessary to reduce costs of medication for @entity65 and @entity6 among subjects with such treatment at baseline. To reduce initiation of new treatment against the two conditions, @entity353 >or=15% was required. Over 6 y, the average annual cost for @entity6 and @entity65 medication increased by 463 SEK (96%) in subjects with @entity353 <5%, and decreased by 39 SEK(8%) in the @entity353 group >or=15%. CONCLUSION: Long-term intentional @entity353 is associated with reduced medication and medication costs for @entity6 and @entity65 . The effects appear to be more marked among subjects who are initially on medication for these conditions, whereas greater weight reduction is needed to prevent new subjects from starting on medication.
