4C.02: PROLONGED @entity11502 -INDUCED HYPERTENSION IMPAIRS SHORT-TERM MEMORY IN ADULT XXXX .

@entity64 @entity101 @entity19 @entity73 @entity15395 @entity11502
OBJECTIVE: @entity73 is a major disability increasing due to population ageing. @entity101 is a major risk factor for the development of vascular @entity73 . However the contribution of @entity101 in the pathological cascade of vascular @entity73 remains elusive. Although few cardiovascular models have shown to be relevant for the study of vascular @entity73 , chronic @entity101 models with established @entity73 are lacking. In particular working and short-term memories have never been investigated. The aim of this study was therefore to evaluate the impact of prolonged @entity11502 -induced @entity101 on working and short-term memories in adult @entity19 . DESIGN AND METHOD: 3-4 months old male C57BL/6 @entity19 were infused during 3 months with @entity11502 at a dose of 2000ng/kg/min ( @entity15395 , n=10) or saline (Control, n=10) via osmotic minipumps. Blood pressure was measured weekly by the tail-cuff method. Garcia neurological test was used to assess motor and behavioural functions to detect eventual @entity64 signs. Working memory was assessed in a Y-maze during an alternation task over 3 months. Finally, evaluation of short-term memory was performed during an object location task (1h intertrial). The resulting discrimination index d2 calculated is an indication of recognition of the novel location of the objects. RESULTS: Systolic blood pressure increased and reached a plateau after 4 weeks (Figure, panel A). Neurological score was unchanged in both groups, suggesting absence of @entity64 . The percentage of alternations was significantly higher in both groups than the chance level of 50% (p<0.05) indicating a functional working memory in both groups. While the alternation rate did not differ between @entity15395 and Control (pint 0.14, pAngII 0.93, ptime 0.51), the discrimination index d2 was different from zero (no discrimination) in Control (p<0.001) but not in @entity15395 (p=0.48) and tended to differ between both groups (p=0.06) (Figure, panel B).(Figure is included in full-text article.) CONCLUSIONS:: In conclusion, we show for the first time that prolonged @entity11502 -induced @entity101 impairs short-term memory in adult @entity19 . Immunohistochemical investigations of brain sections are being done to identify the structural damage involved in this @entity101 model of @entity73 .
