XXXX , @entity227 , and medical risk indicators: a continuous 10-year follow-up study in Type 1 @entity6 @entity1 under routine care.

@entity1 @entity227 @entity6 @entity4 @entity1939 @entity1723 @entity989 @entity1011
The objective of this study was to describe incidence and progression of @entity6 in relation to medical risk indicators as well as @entity227 outcome after a continuous follow-up period of 10 years in a Type 1 @entity6 population treated under routine care. The incidence and progression of @entity989 and their association to HbA(1c), blood pressure, urinary albumin, serum @entity1011 levels, and insulin dosage were studied prospectively in 452 Type 1 @entity6 @entity1 . The degree of @entity989 was classified as no @entity989 , background, or sight-threatening @entity989 , i.e. clinically significant macular @entity4 , severe nonproliferative, or @entity989 . @entity227 was defined as a @entity227 <0.5 and @entity1939 as a @entity227 < or =0.1 in the best eye. In @entity1 still alive at follow-up (n=344), 61% (69/114) developed any @entity989 , 45% (51/114) background @entity989 , and 16% (18/114) sight-threatening @entity989 . Progression from background to sight-threatening @entity989 occurred in 56% (73/131). In 2% (6/335), @entity227 dropped to <0.5 and in less than 1% (3/340) to < or =0.1. @entity1 who developed any @entity989 and @entity1 who progressed to sight-threatening @entity989 had higher mean HbA(1c) levels over time compared to those who remained stable (P<.001 in both cases). @entity1 who developed any @entity989 had higher levels of mean diastolic blood pressure (P=.036), whereas no differences were seen in systolic blood pressure levels between the groups. Cox regression analysis, including all @entity1 , showed mean HbA(1c) to be an independent risk indicator for both development and progression of @entity989 , whereas mean diastolic blood pressure was only a risk indicator for the incidence of @entity989 . Metabolic control is an important risk indicator for both development and progression of @entity989 , whereas diastolic blood pressure is important for the development of @entity1723 . The number of @entity1 who became blind during 10 years of follow-up was low.
