Association Between XXXX and Risk of Cancer in Taiwan.

@entity1 @entity3484 @entity5344 @entity706 @entity1313 @entity5 @entity1489 @entity2 @entity191 @entity150 @entity1820 @entity157 @entity320
Importance: @entity191 ( @entity191 ) has been reported to be associated with a general reduced risk of @entity5 . These studies were mainly carried out in Western populations and little was known about associations in East Asians. Objective: To analyze the association between @entity191 and risk of @entity5 . Design, Setting, and @entity1 : In this cohort study, the data were obtained from the Taiwan National Health Insurance Research Database, which contained information on approximately 24.7 million insured individuals. The cohort included individuals with newly diagnosed as having @entity191 between 2004 and 2010. An age- and sex-matched systematic random-sampling method was used for subject selection in the reference non- @entity191 cohort. Multivariate Cox proportional hazard regression analysis was used to determine the effects of @entity191 on the risks of @entity5 , as shown by hazard ratios (HRs) with 95% CIs. Main Outcomes and Measures: The Taiwan Population Census and National Cancer Registry Databases were used to identify @entity1 with @entity5 . The last follow-up date was December 31, 2012. Results: In 62   023 @entity1 with @entity191 , the HR for all subsequent @entity5 combined was 1.58 (95% CI, 1.50-1.65). Of the 19 types of @entity5 , @entity191 was not associated with @entity5344 . Increased HRs were found in the remaining 16 @entity5 , including malignant @entity1313 (HR, 3.42; 95% CI, 1.84-6.38), @entity1820 (esophageal [HR, 1.81; 95% CI, 1.28-2.57], stomach [HR, 1.59; 95% CI, 1.30-1.94], colorectal [HR, 1.47; 95% CI, 1.31-1.65], liver [HR, 1.89; 95% CI, 1.67-2.14]; gallbladder [HR, 1.73; 95% CI, 1.16-2.57], and pancreas [HR, 1.48; 95% CI, 1.09-2.02]) (P   <   .05 for all comparisons), @entity2 (HR, 1.56; 95% CI, 1.38-1.76), some hormone-related @entity5 (uterine [HR, 1.83; 95% CI, 1.12-3.01], cervical [HR, 1.36; 95% CI, 1.05-1.76], and prostate [HR, 1.80; 95% CI, 1.52-2.13; P   <   .05 for all comparisons), @entity3484 (kidney and @entity150 ; HRs, 1.59 and 1.99, respectively; P   <   .001 for both comparisons), @entity706 (HR, 1.62; 95% CI, 1.31-2.01), @entity320 (HR, 2.75; 95% CI, 1.35-5.59), and other @entity1489 (HR, 1.81; 95% CI, 1.46-2.23). For @entity157 , the highest HR resided in the 50- to 59-year-old group (HR, 2.57; 95% CI, 1.7-3.89). Conclusions and Relevance: Our study concludes that @entity191 is is associated with most @entity5 in Taiwan. Further studies are needed to clarify whether our findings can be applied to other East Asian populations. The differences between our study and most previous cohorts suggest the importance of ethnicity and environmental exposures in disease pathogenesis.
