Predictors of recurrence in XXXX subtypes with negative lymph node in a Chinese population.

@entity1 @entity1377 @entity0 @entity7 @entity5 @entity2347 @entity189 @entity876 @entity513 @entity3 @entity204 @entity420 @entity1722
To establish a series of objective parameters to predict the risk of relapse from axillary lymph node-negative (ANN) @entity0 , and evaluate the patterns of recurrence according to molecular subtypes, we collected information on 2126 consecutive @entity0 @entity1 operated between 2002 and 2006. In this case-control study, 212 @entity1 experiencing recurrence or @entity0 related @entity204 were defined as 'poor group'. Another 212 @entity1 were selected from the remaining cases with stratified sampling method to comprise the 'good group'. Significant differences were found in vascular invasion, grade and molecular subtype between the two groups. Expression of ER and PR in the 'poor group' was lower (P < 0.05). However, positive rates of Ki67, @entity876 and @entity7 in the 'poor group' were higher (P < 0.05). Multivariate analysis revealed that molecular subtype, expression of @entity7 , @entity5 grade, and vascular invasion were closely correlated with bad outcome. Analysis of the 'poor group' demonstrated that ' @entity1722 positive' and 'triple negative' subtypes more commonly suffered from distant metastases and @entity204 . No @entity3 was found in @entity1 with pure invasive @entity1377 , invasive @entity420 or @entity2347 , whereas the diagnoses of invasive @entity189 , invasive @entity189 , invasive @entity1377 mixed @entity513 , or @entity189 were correlated with distant @entity3 and @entity204 . In conclusion, molecular subtype and expression of @entity7 are useful markers for predicting prognosis of ANN @entity0 @entity1 . 'Luminal A-like' subtype has better outcome than others. Moreover, molecular subtypes have different recurrence patterns.
