Nodal immune reactivity in FIGO (International Federation of Gyn-Ob) @entity1204 : relationship with XXXX .

@entity1 @entity1204 @entity404 @entity2940 @entity4071 @entity3 @entity405
BACKGROUND: To evaluate T lymphocyte subsets in pelvic and paraortic lymph nodes, in @entity1 with FIGO @entity1204 at different degrees of @entity3 and with lymphovascular space invasion. The aim was to define an eventual modulation of regional immune reactivity useful in the therapeutic approach of the disease. METHODS: Twenty-two @entity1 with FIGO stage I endometroid adenocarcinoma were consecutively recruited and selected for immunological study. All the @entity1 underwent primary surgery characterized by radical hysterectomy (Piver's type III) with bilateral salpingo-oophorectomy and systematic pelvic plus paraaortic lymphadenectomy. Lymphocyte tipization was performed by Beckton Dickinson monoclonal antibodies ( @entity404 , @entity405 , @entity2940 and @entity4071 ) immunohistochemically in frozen-sections (immune assay on lymph nodes). For statistical evaluations. Student's t test and one way analysis of variance were used. RESULTS: Significantly higher percentages of @entity404 + lymphocytes were found in pelvic than in paraaortic lymph nodes; however, by analyzing T lymphocyte content in the different pelvic nodal groups, we also observed significantly higher percentages of @entity4071 + and @entity2940 + cells in obturator nodes when compared to iliac stations. A significant increase of @entity4071 + and @entity2940 + cell percentages was then defined with respect to myometrial involvement and lymphovascular space invasion, in pelvic nodes. CONCLUSIONS: From our results, we could not define any clinical importance of nodal lymphocyte distribution in @entity1 with early stage @entity1204 ; however, the observed nodal immune reactivity in presence of @entity3 seems interesting, with or without lymph vascular space involvement as possible expression of neoplastic systemic diffusion.
