Multiply recurrent @entity189 with @entity3 and XXXX positivity.

@entity5 @entity189 @entity8844 @entity3 @entity9531 @entity1722
BACKGROUND: @entity189 is an uncommon @entity5 that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, @entity189 is often described as having a rather benign clinical course. Cases of @entity5 recurrence after therapy are uncommon, and @entity5 neurotropism has never been described. OBJECTIVE: A case of multiply recurrent @entity189 with @entity3 is described. The outer root sheath differentiation of this @entity5 is confirmed with the use of novel antibodies directed toward cytokeratins that are expressed in this area of the hair follicle. METHODS: The @entity189 was excised using the Mohs surgical technique. Tissue obtained during the extirpation of the @entity5 was subjected to immunohistochemical staining for @entity8844 , @entity9531 , and @entity1722 . RESULTS: Tumor neurotropism was noted. The @entity189 demonstrated abundant cytoplasmic staining for @entity9531 and @entity1722 . CONCLUSIONS: In distinction to previous reports, this case reveals that @entity189 can demonstrate significant biological aggression, as reflected by @entity5 neurotropism and by failure to respond to multiple surgical excisions. The purported outer root sheath differentiation of this @entity5 is confirmed with the use of novel immunohistochemical staining. This immunohistochemical staining may be useful in differentiating @entity189 from other clear cell neoplasms.
