XXXX mediates the pro-inflammatory effect of latex of Calotropis procera in @entity35 .

@entity32 @entity12698 @entity7782 @entity11464 @entity4 @entity5526 @entity4478 @entity619 @entity112 @entity35 @entity17567
INTRODUCTION: Calotropis procera is known to produce @entity5526 and the latex of this plant produces intense @entity32 when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the @entity32 induced by latex of C. procera in a @entity35 paw @entity4 model and determined the role of @entity112 in latex-induced @entity32 . METHODS: Inflammation was induced in the hind paw of @entity35 by injecting different doses of dried latex (DL) of C. procera. The inhibitory effect of @entity11464 , @entity619 , @entity12698 , @entity7782 , @entity17567 and compound 48/80 on @entity4 volume was evaluated and compared with that against carrageenan. The @entity112 content of DL was measured fluorometrically. RESULTS: DL produced dose-dependent @entity32 of the @entity35 paw. @entity7782 and @entity17567 effectively inhibited DL-induced @entity32 (90%; p < 0.01), while anti-inflammatory drugs @entity11464 , @entity619 and @entity12698 were more effective against carrageenan-induced @entity32 . Depletion of mast cell @entity112 by compound 48/80 produced a significant decrease in DL-induced @entity32 as compared with carrageenan (500% versus 25%). DL was also found to contain about 6 microg/g of @entity112 . CONCLUSIONS: Thus, our study shows that the biogenic @entity4478 play a significant role in C. procera latex-induced @entity32 and antihistaminic drugs could be effectively used to inhibit inflammatory response elicited by exposure to latex.
