Surgical versus medical treatment for XXXX with @entity302 in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study).

@entity1 @entity410 @entity302
OBJECTIVE: To compare the @entity410 and developmental outcomes in @entity1 and young @entity1 with @entity302 who have undergone surgical and medical treatments. METHODS: An international, multicenter, observational cohort study was undertaken. A total of 317 @entity1 aged <6years, who had frequent disabling @entity410 despite intensive medical treatments, were registered. Among the enrolled @entity1 , 250 were treated medically (medical group), 31 underwent resective surgery (resective group), and 36 underwent palliative surgery [callosotomy (n=30) or vagal nerve stimulation (n=6); palliative group] on admission. @entity410 and developmental outcomes were obtained for 230 @entity1 during the 3-year follow-up period. Cox proportional hazard model was used to adjust for clinical backgrounds among treatment groups when comparing the @entity410 -free survival rates. RESULTS: At the 3-year follow-up, @entity410 -free survival was 15.7%, 32.1%, and 52.4% in the medical, palliative, and resective groups, respectively. The adjusted hazard ratios for @entity410 recurrence in the resective and palliative groups versus the medical group were 0.43 (95% CI, 0.21-0.87, P=0.019) and 0.82 (95% CI, 0.46-1.46, P=0.50), respectively; the former was statistically significant. Regarding the developmental outcome, the mean DQs in the resective group increased significantly compared to those in the medical group during the follow-up (P<0.01). As for subgroup analysis, better @entity410 and development outcomes were demonstrated in the resective group compared to the medical group in @entity1 with @entity302 (those to which no known @entity302 syndromes were applicable). SIGNIFICANCE: These results suggest that surgical treatments, particularly resective surgeries, are associated with better @entity410 and developmental outcomes compared with successive medical treatment. The present observations may facilitate the identification of @entity1 and young @entity1 with @entity302 who could benefit from surgery.
