Prenatal diagnosis of clubfoot: XXXX associated with fetal defects and outcome in a tertiary center.

@entity2008 @entity5149 @entity2007 @entity85
PURPOSE: Our aim was to evaluate the rate of occurrence of @entity2008 , associated findings, and outcome in a series of cases of prenatally diagnosed clubfoot. METHODS: We conducted a retrospective study of all cases of clubfoot diagnosed prenatally in the ultrasound unit of a French tertiary center from January 2004 through December 2011. Clubfoot was scored as complex or isolated depending on the presence or absence of another structural abnormality observed on sonographic examination. RESULTS: Data from 90 fetuses prenatally diagnosed with clubfoot were included in this study. Thirty-four cases were considered complex (38%) and 56 were considered isolated (62%). A @entity2008 was identified in 10 of 33 of the fetuses with complex clubfoot and in 1 of 45 of those with @entity5149 (p   <   0.001). Clubfoot was associated with a poor outcome in 5 of 52 cases of @entity5149 and in 31 of 34 cases associated with other structural defects (p   <   0.001). The @entity85 was bilateral in 62 cases (69%) and unilateral in 28 (31%). No statistically significantly higher rate of poor outcome was identified when the @entity85 occurred bilaterally nor was a significantly higher rate of @entity2008 noted in this condition. CONCLUSIONS: @entity2007 and adverse pregnancy outcomes occur more commonly in prenatally diagnosed cases of complex clubfoot than in those of @entity5149 . Fetal karyotyping is required in cases of complex clubfoot, but the need for that procedure in @entity5149 remains controversial.    2015 Wiley Periodicals, Inc. J Clin Ultrasound, 2015.
