XXXX and radiation therapy for inoperable or recurrent parotid carcinoma. A phase I/II study.

@entity1 @entity137 @entity39 @entity5 @entity221
BACKGROUND: The treatment of advanced, inoperable, or recurrent @entity5 represents a clinical challenge. The results obtained with conventional radiotherapy are disappointing. To improve the early response and local control of @entity5 , local microwave @entity221 was used in combination with ionizing radiation in a biinstitutional Phase I/II study. METHODS: From 1984 to 1991, 13 @entity1 (20 lesions) with advanced (10 lesions) or recurrent (10 lesions) @entity5 (15 primaries and the remaining 5 nodal metastases), were treated with 300-915 MHz of external @entity221 after external irradiation. Heat was applied twice weekly at a minimum desired temperature of 42.0 degrees C for 30 minutes at steady state. Ionizing radiation was delivered using photon, electron, or mixed electron-photon beams; the prescribed total dose was 70 Gy and 30 Gy for untreated and previously treated lesions, respectively; the median computed total dose was 66 Gy for previously untreated @entity1 (range, 56-70 Gy) and 30 Gy for previously irradiated @entity1 (range, 28-32 Gy). RESULTS: Acute side effects were limited. Major acute @entity137 included three @entity1 (15%) with superficial @entity39 , two of three who healed spontaneously in 4 and 6 months. Clinical response evaluated during the third month after the completion of therapy found that 16/20 @entity1 (80%) had a complete response (CR), and 4 (20%) had a partial response. Four out of 16 @entity1 who had CRs (20%) had a local recurrence, resulting in an actuarial local control at 5 years of 62.3 +/- 13.2%. CONCLUSIONS: The combined treatment of local microwave @entity221 and ionizing radiation proved to be feasible and moderately toxic for @entity1 with advanced, inoperable, or recurrent @entity5 . Even if clinical result evaluation was not the study endpoint, early response, and 5-year local control rates were encouraging.
