Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of XXXX .

@entity32 @entity4315 @entity137 @entity2951 @entity1042 @entity19 @entity4 @entity635 @entity1426 @entity3971 @entity112 @entity777 @entity40065 @entity272 @entity35 @entity5068 @entity3927 @entity637 @entity1909
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Pereskia aculeata Miller (Cactaceae), known as Barbados gooseberry, are used in Brazilian traditional medicine as emollients and to treat @entity272 and @entity32 . This study investigated the topical anti-inflammatory activity of the @entity4315 fraction (HF) obtained from the @entity1042 extract of the leaves of this species in models of @entity1909 in @entity19 . MATERIAL AND METHODS: @entity19 ear @entity4 was induced by topical application of croton oil, @entity1426 , @entity2951 , @entity40065 and @entity3971 ; and by subcutaneous injection of @entity112 . Ear biopsies were obtained to determine the levels of @entity635 , @entity777 and @entity637 cytokines by ELISA assay. Histopathological analysis was also performed to evaluate the HF activity in croton oil multiple application test. In addition, acute dermal irritation/corrosion test in @entity35 was accomplished. HF chemical characterization was performed by GC-MS analysis. RESULTS: HF intensively reduced the inflammatory process induced by all irritant agents used, except for @entity1426 . This activity is related, at least in part, to the reduction of @entity777 and @entity637 cytokines levels. Moreover, when the glucocorticoid receptor antagonist @entity3927 was used, HF failed to respond to the croton oil application.The results strongly suggested a glucocorticoid-like effect, which was reinforced by the presence of considerable amounts of @entity5068 compounds identified in HF. The acute dermal irritaton/corrosion test showed no signs of @entity137 . CONCLUSIONS: This study showed that the acute and chronic anti-inflammatory activity of P. aculeata leaves is very promising, and corroborates to better understand their ethnopharmacological applications.
