Effect of Food Status on the Gastrointestinal Transit of XXXX -Containing Solid Lipid Nanoparticles in @entity35 .

@entity2379 @entity5 @entity237 @entity35 @entity1443 @entity6353 @entity3378 @entity27009
UNASSIGNED: @entity2379 ( @entity237 ) is poorly absorbed from the gastrointestinal tract. Recent studies have suggested enhanced drug absorption from @entity5 ( @entity5 ). Little is known of the fate of @entity237 absorption within the gastrointestinal tract, and no gastrointestinal transit study has yet been performed on @entity237 -containing nano-formulations. We aimed to investigate the effect of food on the gastrointestinal transit properties of an @entity237 -containing @entity5 in @entity35 . Three SLNs containing @entity237 , @entity1443 , or @entity3378 were formulated using @entity6353 butter and beeswax as lipid matrices and simultaneously administered orally to @entity35 . @entity1443 and @entity27009 were used as marker drugs for estimating gastric emptying and cecal arrival, respectively. The pharmacokinetic data generated for @entity1443 and @entity27009 were used in estimating the absorption of the @entity237 SLNs in the small and large intestines, respectively. A delayed rate of @entity237 absorption was observed in the fed state; however, the extent of absorption was not affected by food. Specifically, the percentages of @entity237 absorption during the fasted state in the stomach, small intestine, and colon were not significantly different from absorption within the respective regions in the fed state. In both states, however, absorption was highest in the colon and appeared to be a combination of absorption from the small intestine plus absorption proper within the colon. The study suggests that @entity237 @entity5 , irrespective of food status, is slowly but predominantly taken up by the lymph, making the small intestine the most favorable site for the delivery of the @entity237 SLNs.
