Alkaline phosphatase normalization is associated with better prognosis in XXXX .

@entity1 @entity991 @entity409 @entity201 @entity10055
BACKGROUND: @entity991 results in elevated but fluctuating serum alkaline phosphatase levels that occasionally return to normal. AIMS: To investigate the frequency of normalization of alkaline phosphatase in newly diagnosed @entity991 @entity1 and the subsequent clinical outcomes. METHODS: Records of newly diagnosed @entity991 @entity1 were examined retrospectively for laboratory values and clinical end points ( @entity201 , @entity409 ) within 10 years of diagnosis. Data from a recent prospective @entity10055 treatment trial were also studied. RESULTS: Eighty-seven @entity1 met the inclusion criteria. Normalization of alkaline phosphatase was seen in 35 (40%) @entity1 . Five (14%) @entity1 with normalization reached an end point whereas 17 (33%) of the @entity1 with persistent elevation reached an end point (P = 0.02). @entity10055 was used similarly by both groups. When the investigative criteria were applied to a prospective trial, there was again a significant relationship between normalization of alkaline phosphatase and survival in @entity1 receiving @entity10055 (P < 0.01) and the placebo group (P = 0.02). CONCLUSIONS: Serum alkaline phosphatase was found to normalize in a high proportion of newly diagnosed @entity991 @entity1 . This was significantly associated with a better prognosis in a retrospective cohort and when data from a prospective treatment trial was evaluated.
