Focusing on delayed clearance for identifying small-sized metastatic XXXX using synchrotron radiation angiography with a highly sensitive receiver.

@entity35 @entity11 @entity2 @entity5
OBJECTIVES: To detect metastatic @entity2 of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensitivity receiver. METHODS: C6 cells, derived from @entity35 @entity11 cells, were injected to the @entity35 tail vein. Two weeks after injection, the @entity35 underwent SR angiography using a high-gain avalanche rushing amorphous photoconductor (HARP) receiver of extra-high sensitivity with high contrast resolution. The 256-grayscale value was employed in the analysis of images. RESULTS: 19 nodules were identified in images. The @entity5 were confirmed histopathologically. The average @entity5 size was 621  193   m. The clearance curve of the densities was expressed as a logarithm function. @entity5 showed delayed clearance of contrast material, taking up to 28 s, compared with arteries, which cleared rapidly at 8 s. In 256 grayscale, the distance was 50. This gap in density clearance made it possible to identify @entity5 . CONCLUSIONS: SR angiography with a HARP receiver provides high sensitivity and spatial resolution and makes it possible to diagnose metastatic @entity2 of less than 1 mm in size by focusing on differences in the clearance times of contrast material.
