Outcomes Following Extended Surgery for XXXX : Results From a UK Referral Centre.

@entity1 @entity242 @entity5 @entity260 @entity204
BACKGROUND: Primary extended resection has been proposed as the initial treatment for @entity1 with @entity242 . This approach comprises an extended en-bloc resection of the directly infiltrated organs and adjacent uninvolved organs. The results of such radical surgery have yet to be validated. This retrospective study aims to investigate this practice in a contemporary series from a referral center in the UK. METHODS: We extracted data from consecutive @entity1 who underwent extended resectional surgery between 2009 and 2013, and investigated the type of resection performed, the effectiveness of extended surgery in providing negative microscopic margins, and the occurrence of post-surgical adverse events. RESULTS: A total of 69 @entity1 were included. Fifty-two @entity1 had a primary @entity5 (75.4  %), and in 55 @entity1 (79.7  %) the @entity5 was resected en bloc with adjacent organs or structures. Colonic resection (N  =  35, 50.7  %) and nephrectomy (N  =  28, 40.6  %) were the most frequently performed organ resections. Organs were infiltrated in 22 @entity1 (32  %), and there was no association between organ infiltration and @entity1 variables and staging characteristics. Negative microscopic margins were achieved in 88.6  % of @entity1 in this series. @entity260 occurred in 21 @entity1 (30  %) and a reoperation was required in ten cases (14.5  %). No independent predictors of morbidity were identified and no 30-day postoperative @entity204 occurred. CONCLUSIONS: Four-fifths of @entity1 in this series had organs removed in association with the @entity242 . This approach in a specialist sarcoma unit results in negative microscopic @entity5 margins in up to 90  % of cases and can be performed safely.
