Acquired @entity1422 associated with XXXX : a case report and review of the literature.

@entity1 @entity1071 @entity548 @entity882 @entity1423 @entity706 @entity1427 @entity1422 @entity978
BACKGROUND: Acquired @entity1422 is a rare @entity548 resulting from impaired adhesive function of the platelet receptor @entity1427 /IIIa (alpha(IIb)beta3). Typically, this disorder develops during adulthood, with @entity1 manifesting fluctuating clinical and laboratory findings. To date, the underlying defect of most if not all cases of acquired @entity1422 results from an autoantibody or plasma protein inhibitor directed toward a demonstrably normal @entity1427 /IIIa glycoprotein. METHODS: In this report, a @entity1 with a history of treated @entity978 presented with a severe @entity548 characterized by mild @entity882 , a prolonged bleeding time, and defective @entity1423 . RESULTS: Examination of the @entity1 's platelet @entity1427 /IIIa by Western blot analysis revealed no abnormality. Mixing studies demonstrated a non-immunoglobulin G plasma inhibitory factor, whereas flow cytometry analysis revealed elevated platelet-associated immunoglobulin (Ig) M. After an emergency colectomy for severe @entity548 , the @entity1 's qualitative and quantitative platelet parameters significantly improved. Pathology of the resected colonic segment demonstrated atypical @entity706 . CONCLUSIONS: To the authors' knowledge, this is the first reported case of acquired @entity1422 associated with a putative IgM autoantibody. Furthermore, this report verifies the association of acquired @entity1422 with @entity1071 . Although rare, awareness of this @entity548 as a possible sequelae of active or treated @entity706 should encourage clinical vigilance of these @entity1 .
