Nuclear receptor variants in XXXX .

@entity1 @entity2538 @entity6 @entity2299 @entity409 @entity16566 @entity5990 @entity4961 @entity19454 @entity1561 @entity201 @entity99 @entity9744
This snapshot reviews the current state of knowledge on genetic variants of nuclear receptors (NRs) involved in regulating various aspects of liver metabolism. Interindividual differences in responses to diet and other 'in-' and environmental stressors can be caused by variants in components of the NR regulatory gene network. We recapitulate recent evidence for the application of NRs in genetic diagnosis of monogenic @entity409 . Genetic analysis of multifactorial @entity409 , such as @entity1561 and @entity6 , pinpoints key players in disease predisposition and progression. In particular, @entity4961 variants have been associated with @entity9744 of pregnancy and @entity5990 . Other examples include studies of @entity16566 and @entity19454 polymorphisms in @entity1 with @entity99 and @entity2538 variation in @entity201 . Associations of NR gene variants have been identified in @entity1 with @entity2299 and other metabolic syndrome-associated traits by genome-wide studies. Evidence from these analyses confirms a role for NR variation in common diseases, linking regulatory networks to complex and variable phenotypes. These new insights into the impact of NR variants offer perspectives for their future use in diagnosis and treatment of common diseases.    2015 S. Karger AG, Basel.
