Correlation of matrix metalloproteinase levels with the grade of proliferative XXXX in the subretinal fluid and vitreous during @entity1713 .

@entity1 @entity5379 @entity1715 @entity3334 @entity1476 @entity1713 @entity2843 @entity5952
PURPOSE: We investigated the activity of @entity5379 and their latent pro-forms (proMMP-2, -9), and protein levels of @entity3334 and tissue inhibitor of MMPs (TIMP)-1 in the subretinal fluid (SRF) and vitreous of @entity1 with @entity1713 ( @entity1713 ). Potential correlations with proliferative @entity1715 (PVR) grade were determined. METHODS: Thirty-seven SRF and 32 vitreous samples from @entity1713 @entity1 and nine vitreous samples from @entity1 organ donors (controls), were collected and assayed for @entity3334 / @entity2843 levels using enzyme-linked immunosorbent assay (ELISA), and for proMMP-2, -9, @entity1476 , -9 activity employing gelatine zymography. RESULTS: ProMMP-2, -9, @entity3334 , @entity2843 were significantly higher in the SRF and vitreous of @entity1713 @entity1 compared to the vitreous of organ donors. @entity5952 levels were higher in @entity1713 @entity1 ' SRF. Regarding PVR grade, MMPs and @entity2843 were differentially present in SRF and vitreous. PVR grade correlated significantly with the levels of @entity1476 in SRF, while proMMP-2, @entity3334 and @entity2843 levels correlated with PVR grade in the vitreous. CONCLUSION: MMP/ @entity2843 levels are elevated in SRF and vitreous during @entity1713 . Significant correlations between PVR grade and @entity1476 in SRF and proMMP-2, @entity3334 and @entity2843 levels in vitreous were revealed. Investigation of MMP activity in vitreous may provide more valid conclusions compared to SRF pertaining to the role of the MMPs during @entity1713 . The observations of the present study suggest a possible role for MMPs and @entity2843 in PVR pathophysiology.
