Cerebellar stimulation for XXXX --double blind study.

@entity1 @entity508 @entity306
Twenty @entity306 ( @entity306 ) @entity1 undergoing chronic cerebellar stimulation (CCS) for reduction of @entity508 and improvement in function have participated in a double-blind study. Seven US centers involving 9 neurosurgeons (1984-6) have replaced the depleted Neurolith 601 fully implantable pulse generator (Pacesetter Systems Incorp.-Neurodyne Corp., Sylmar, CA) with new units in 19 @entity306 @entity1 , 1 @entity1 entered the study following his initial implant. A magnetically controllable switch was placed in line between the Neurolith stimulator and the cerebellar lead, so allowing switching sequences for the study. Physical therapists, living in the vicinity of the @entity1 's home, carried out two quantitative evaluations: 1. Joint angle motion measurements (passive and active). 2. Motor performance testing was done when possible and included: reaction time, hand dynamonetry, grooved peg board placement, hand/foot tapping, and rotary pursuit testing. Testing was done presurgery, at 2 weeks postimplant, then the switch was activated either "on" or "off" to a schedule, with testing and reswitching at 1, 2 and 4 months, then the switch was left turned "on". Of the 20 @entity1 , 16 finished the tests, 2 @entity1 failed to finish and 2 had switch problems and were deleted from the study. Two of the 16 @entity1 were "off" through the entire testing. Of the 14 that had periods of the stimulator being "on", 10 @entity1 (72%) had quantitative improvements of over 20%, (1 pt: 50+% improvements; 4 pts: 30-50%, 5 pts: 20-30%); while 1 @entity1 (7%) had improvements in the 10-20% level, whereas 3 @entity1 (21%) showed no improvement.
