A new approach to delineating lymph node target volumes for post-operative radiotherapy in XXXX : A phase II trial.

@entity1 @entity4181 @entity137 @entity390 @entity417 @entity5 @entity254 @entity1398 @entity204 @entity356 @entity1487
PURPOSE: In the context of @entity356 , lymph node target volume delineation for post-operative radiotherapy is currently built on the traditional system of dividing the stomach and 2-D treatment methods. Here, we have proposed a new delineation approach with irradiation indications for lymph node stations. Its safety and efficacy were evaluated in a phase II clinical trial. MATERIALS AND METHODS: Fifty-four @entity356 @entity1 with D2 lymph node dissection received 2 cycles of FOLFOX4. They subsequently received concurrent chemoradiotherapy (45Gy at 1.8Gy per fraction, 5 fractions per week for 5weeks) with a @entity1487 / @entity4181 regimen, followed by 4 additional FOLFOX4 cycles. The target volume included the remnant stomach, @entity254 site, @entity5 bed, and regional lymph nodes selected through our new approach by taking gastric arteries as references. RESULTS: The most common grade 3-4 adverse event was @entity1398 (14.8%). @entity1398 , @entity417 , and @entity390 were common grade 1-2 @entity137 . No treatment-related @entity204 occurred during treatment. The 3-year overall, disease-free, and locoregional recurrence-free survival rates were 81.6%, 70.2%, and 91.1%, respectively. Eight @entity1 developed peritoneal or distant metastases. CONCLUSIONS: Using our new approach and irradiation indications, delineation of the target volume of post-operative lymph node stations was feasible and well tolerated after D2 resection in @entity1 with @entity356 .
