Evaluation of the individual 50% inhibitory area under the concentration curve of XXXX based on the collagen gel droplet embedded culture drug sensitivity test in @entity14 .

@entity1 @entity5 @entity4620 @entity14 @entity1487
We have previously reported the @entity1487 ( @entity1487 ) sensitivity of @entity5 cells from @entity14 ( @entity14 ) @entity1 using the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) under multiple drug concentrations and contact durations. Moreover, the area under the concentration curve (AUC) and growth inhibition rate (IR) were combined, resulting in the AUC-IR curve, which was approximated to the logarithmic curve. In the present study, we used the AUC-IR curve to calculate the individualized AUCIR50, the AUC value that imparts 50% growth inhibition. Individual AUCIR50 was calculated in @entity14 @entity1 , and its distribution was evaluated. The cumulative distribution of individual AUCIR50 was regressed over two lines (logarithmic scale). Among the 45 resectable @entity14 @entity1 , those who achieved more than the individual AUCIR50 during post-operative @entity1487 -based chemotherapy demonstrated a trend towards better disease-free survival compared to those who did not achieve AUCIR50. Of the @entity4620 @entity1 (n=10), those who achieved more than twice the individual AUCIR50 during post-operative @entity1487 -based chemotherapy demonstrated significantly better survival rates (p=0.05) than those who did not. In this study, the distribution of the individual AUCIR50 suggested that approximately 6% of @entity1 demonstrated very low @entity1487 sensitivity. Therefore, the individual AUCIR50 was useful in classifying good, intermediate and poor @entity1487 response. Achievement of the individual AUCIR50 may be a prerequisite for individualized @entity1487 -based adjuvant chemotherapy. As well, the early achievement of twice the individual AUCIR50 may indicate an improved prognosis in @entity4620 @entity1 . The individual AUCIR50 using CD-DST is useful in determining the individualized chemotherapy of @entity14 @entity1 , thus CD-DST has the potential to facilitate the establishment of individualized chemotherapy for @entity14 .
