Prognostic significance of positive peritoneal cytology in XXXX confined to the uterus.

@entity1 @entity3 @entity1204
A retrospective analysis was performed to evaluate the prognostic significance of peritoneal cytology in @entity1 with @entity1204 limited to the uterus. A total of 280 @entity1 with surgically staged @entity1204 that was histologically confined to the uterus were examined clinicopathologically. The median length of follow-up was 62 (range, 12-135) months. All @entity1 underwent hysterectomy and salpingo-oophorectomy with selective lymphadenectomy, and only three @entity1 received adjuvant postoperative therapy. No preoperative adjuvant therapy was employed. In all, 48 @entity1 (17%) had positive peritoneal cytology. The 5-year survival rate among @entity1 with positive or negative peritoneal cytology was 91 or 95%, respectively, showing no significant difference (log-rank, P=0.42). The disease-free survival rate at 36 months was 90% among @entity1 with positive cytology, compared with that of 94% among @entity1 with negative cytology, and the difference was not significant (log-rank, P=0.52). Multivariate proportional hazards model revealed only histologic grade to be an independent prognostic factor of survival (P=0.0003, 95% CI 3.02 - 40.27) among the factors analysed (age, peritoneal cytology, and depth of @entity3 ). Multivariate analysis revealed that histologic grade (P=0.02, 95% CI 1.21-9.92) was also the only independent prognostic factor of disease-free survival. We concluded that the presence of positive peritoneal cytology is not an independent prognostic factor in @entity1 with @entity1204 confined to the uterus, and adjuvant therapy does not appear to be beneficial in these @entity1 .
