Histologic study of peritoneal adhesions in @entity1 and in a XXXX model.

@entity1 @entity2708 @entity1711 @entity1661 @entity5744 @entity1710 @entity35 @entity298
@entity298 ( @entity298 ) represent a major cause of morbidity in pediatric surgical @entity1 . The pathogenesis is still largely unknown. A possible role could be played by @entity5744 ( @entity5744 ) accidentally contaminating the operative field during surgery. We report a histologic study of @entity298 in a @entity35 model and in @entity1 , investigating the role of @entity5744 in their formation. @entity1661 were studied in 18 @entity35 . In 6 (group A) we performed a laparotomy and rubbed the visceral and parietal peritoneum with a @entity2708 bud. In 6 (group B) we performed a minimal laparotomy and injected powdered autologous and heterologous material into the peritoneal cavity, avoiding any peritoneal abrasions. In 6 (group C) we performed a laparotomy and applied both treatment methods, i.e., rubbing and injection of @entity5744 . After 1 month, at autopsy @entity35 were classified according to the presence and grade of surgical adhesions. Twenty-two @entity298 were also collected from seven @entity1 undergoing abdominal surgery in whom one or more procedures had been previously performed. The adhesions were stained with @entity1710 - @entity1711 and Giemsa stains for histologic examination. Adhesions were found in 4 @entity35 of group A and all 6 @entity35 of group C. None were identified in group B. Group C @entity35 showed a higher grade of adhesions with respect to group A. In both @entity1 and animals @entity298 were always found to coexist with microscopic particles of solid substances, which were incorporated inside the connective tissue. However, after simple injection of @entity5744 into the abdominal cavity we did not observe any @entity298 . These data suggest that two different stimuli are necessary for adhesion formation: a direct lesion of the mesothelial layers and a solid substrate ( @entity5744 ). We underline the importance of reducing contamination with @entity5744 during surgery. On the basis of these considerations, the laparoscopic approach seems to be particularly pertinent.
