XXXX and @entity2227 control area-restricted search behavior in @entity2199 .

@entity7303 @entity2199 @entity2227 @entity935 @entity70968 @entity70969 @entity70970 @entity11641
Area-restricted search (ARS) is a foraging strategy used by many animals to locate resources. The behavior is characterized by a time-dependent reduction in turning frequency after the last resource encounter. This maximizes the time spent in areas in which resources are abundant and extends the search to a larger area when resources become scarce. We demonstrate that dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the @entity2199 @entity2199 . Ablation of dopaminergic neurons eliminated ARS behavior, as did application of the @entity935 receptor antagonist @entity11641 . Furthermore, ARS was affected by mutations in the @entity2227 receptor subunits @entity70968 and @entity70969 and the @entity70970 @entity2227 vesicular transporter. Interestingly, preincubation on @entity935 restored the behavior in worms with @entity7303 , but not in @entity70968 , @entity70969 , or @entity70970 mutants. This suggests that dopaminergic and glutamatergic signaling function in the same pathway to regulate turn frequency. Both @entity70968 and @entity70969 are expressed in the locomotory control circuit that modulates the direction of locomotion in response to sensory stimuli and the duration of forward movement during foraging. We propose a mechanism for ARS in @entity2199 in which @entity935 , released in response to food, modulates glutamatergic signaling in the locomotory control circuit, thus resulting in an increased turn frequency.
