A retrospective comparison of XXXX dosing regimens for pediatric procedural sedation.

@entity1 @entity8844 @entity7434 @entity3652
OBJECTIVE: @entity3652 is a dissociative agent often used in pediatric emergency departments for procedural sedation. Institutions commonly use either 1.5 mg/kg ( @entity8844 ) or 1 mg/kg ( @entity7434 ) as intravenous dosing. We sought to determine whether @entity1 receiving @entity7434 require more administered doses during sedation than @entity1 receiving @entity8844 . Furthermore, we examined whether differences existed between @entity7434 and @entity8844 in the total dosage, total mg/kg, and time to recovery. @entity1 AND METHODS: A retrospective chart review examining procedural sedations from July 2010 through December 2011 was performed for sedations using @entity7434 or @entity8844 . Cohorts were compared on the basis of the number of doses, mg/kg administered, total dosage (mg), and adverse events. RESULTS: A total of 346 @entity1 were included, with 159 @entity1 in @entity7434 and 187 @entity1 in @entity8844 . No significant differences in demographics were observed between @entity7434 and @entity8844 . @entity1 in @entity8844 required fewer median doses of @entity3652 compared with @entity7434 (1.0 vs. 2.0, P=0.02). @entity7434 had a higher median overall mg/kg dosage (1.71 mg/kg) than @entity8844 (1.60 mg/kg) (P<0.01). @entity8844 showed a decrease in the number of sedations requiring a third dose of @entity3652 to complete sedation as compared with @entity7434 (7.57 vs. 18.47%, P=0.002). No significant difference in adverse events was found between @entity7434 and @entity8844 . CONCLUSION: Sedations using @entity8844 require fewer doses, lower mg/kg administered, but a higher total dose than @entity7434 . No difference was found in the rate of adverse events between the groups. Our findings suggest that @entity3652 sedations can be completed safely with one dose when @entity1 are initially dosed at 1.5 mg/kg.
