Clinicopathologic and immunohistochemical study of surgically treated primary XXXX .

@entity1 @entity588 @entity706 @entity6595 @entity5 @entity1074 @entity876 @entity1534 @entity13639
BACKGROUND AND OBJECTIVES: B-cell @entity1074 is a well-recognized entity and its characterization as low-grade (LG) and high-grade (HG) @entity706 has been widely accepted. In the present study we reviewed a series of 95 surgical specimens of primary @entity6595 selected between 1979 and 1998. Immunohistochemical expression of @entity876 , @entity588 , and Ki67 and @entity1534 (Hp) infection was evaluated, along with a correlation with clinical outcome. METHODS: A morphologic and immunohistochemical analysis, including @entity876 , @entity588 , and Ki67 expression, was carried out in all cases. A complete follow-up was obtained in 49 @entity1 and in these cases a survival analysis was performed. RESULTS: @entity588 protein was highly expressed in 25 of 25 assessed @entity5 and in 20 of 24 assessed @entity5 . @entity876 protein was expressed in 13 of 25 assessed @entity5 and in 21 of 24 assessed @entity5 . High proliferation rate as expressed by Ki67 was detected in 15 of 25 assessed @entity5 and in 23 of 24 assessed @entity5 . @entity13639 was detected in 11 of 16 assessed @entity5 and 2 of 10 assessed @entity5 . Median survival rates were 72 months for @entity5 and 24 months for @entity5 . CONCLUSIONS: A significant inverse relationship between @entity13639 and histological grade was found. High @entity876 expression and high-proliferation rate correlated with @entity5 . However, a correlation between @entity876 , @entity588 , and Ki67 expression with clinical outcome was not found.
