Global patterns of large XXXX in the @entity1 genome reveal complexity in chromosome organization.

@entity853 @entity1 @entity471
UNASSIGNED: Global patterns of @entity853 ( @entity853 ) in chromosomes are required to understand the dynamics of genome organization and complexity. For this study, analysis was performed using the Affymetrix Genome-Wide @entity1 SNP Array 6.0 chip and CytoScan High-Density arrays. We identified a total of 44 109 @entity853 from 1715 genomes with a mean of 25 @entity853 in an individual, which established the first drafts of population-specific @entity471 maps providing a rationale for prioritizing chromosomal regions. About 19 905 ancient @entity853 were identified across all chromosomes and populations at varying frequencies. @entity471 count, and sometimes @entity471 size, contributed to the bulk @entity471 size of the chromosome. Population specific lengthening and shortening of chromosomal length was observed. Sex bias for @entity471 presence was largely dependent on ethnicity. Lower @entity471 inheritance rate was observed for India, compared to YRI and CEU. A total of 33 candidate @entity471 hotspots from 5382 copy number (CN) variable region (CNVR) clusters were identified. Population specific @entity471 distribution patterns in p and q arms disturbed the assumption that @entity471 counts in the p arm are less common compared to long arms, and the @entity471 occurrence and distribution in chromosomes is length independent. This study unraveled the force of independent evolutionary dynamics on genome organization and complexity across chromosomes and populations.
