Intravenous versus intracoronary streptokinase in XXXX .

@entity1 @entity662 @entity1188 @entity453 @entity583
One hundred sixty-four consecutive @entity1 with @entity583 were enrolled in a prospective trial of coronary thrombolysis with streptokinase (STK). The first 98 @entity1 received intracoronary (i.c.) STK after coronary angiography and the next 66 received a high-dose rapid infusion of STK (900,000 IU) intravenously (i.v.) before angiography. First-pass radionuclide ejection fraction (EF) was performed early (within 24 hours of admission) and late (10 to 14 days after admission) to evaluate left ventricular function. In the i.v. group, 42 of 66 (64%) of @entity1188 were patent at the initial angiogram and 6 (9%) opened with subsequent i.c. STK. In the i.c. group, 13 of 98 (13%) of @entity1188 were patent at the initial angiogram and 50 of 85 (59%) opened with the i.c. STK. The i.v. and i.c. groups did not differ in time from onset of @entity662 to presentation, type of @entity1188 or underlying severity of @entity453 . In the i.v. group, STK was begun 67 minutes earlier than in the i.c. group. In 62 @entity1 in whom reperfusion was successful, mean EF increased from 39 +/- 11% early to 48 +/- 13% late. In 30 in whom it was not, the mean EF increased from 36 +/- 10% to 40 +/- 12%. The increase in EF was significantly greater in @entity1 in the reperfused group (p less than 0.03). In 18 @entity1 who underwent reperfusion by i.v. STK, the mean EF increased 11 +/- 12%, whereas in 44 @entity1 who had reperfusion by i.c. STK, the mean EF increased 9 +/- 10% (difference not significant).(ABSTRACT TRUNCATED AT 250 WORDS)
