XXXX involving the gastrointestinal and the urinary tracts in primary Sj  gren's syndrome.

@entity1 @entity16 @entity4148 @entity5433 @entity934
OBJECTIVE: Antibodies reacting with the m3 subtype muscarinic @entity934 receptor appear to be an important pathogenic factor in primary Sj  gren's syndrome (pSS). As this receptor subtype is functionally important in the gastrointestinal and urinary tracts, and very little is known about the autonomic nervous system function in these organs in pSS @entity1 , the occurrence and clinical significance of an @entity16 involving the gastrointestinal and urinary tracts were investigated. METHODS: Data on clinical symptoms attributable to an @entity5433 were collected from 51 pSS @entity1 . Gastric emptying scintigraphy and urodynamic studies were performed on 30 and 16 @entity1 , respectively, and the results were correlated with @entity1 characteristics and with the presence of @entity4148 . RESULTS: Gastric emptying was abnormally slow in 21 of the 30 examined @entity1 (70%). Urodynamic findings, compatible with a decreased detrusor muscle tone or contractility were found in 9 of the 16 @entity1 tested (56%). Various symptoms of an @entity16 were reported by 2-16% of the @entity1 . CONCLUSION: Signs of an @entity16 involving the gastrointestinal and the urinary systems can be observed in the majority of pSS @entity1 . This high occurrence is rarely associated with clinically significant symptoms. The authors presume a role of autoantibodies reacting with the m3 muscarinic @entity934 receptor in the elicitation of the @entity5433 .
