XXXX and @entity1701 .

@entity1 @entity533 @entity75 @entity1457 @entity9500 @entity1252 @entity1701 @entity166 @entity2263 @entity731 @entity792 @entity65
@entity731 is an @entity792 associated with @entity166 , inflammatory, and autoimmune factors. Both humoral and cellular immune mechanisms have been proposed to participate in the onset and/or progression of @entity75 . @entity1457 protein (hsp), oxidized low-density lipoprotein (LDL), and @entity9500 have been reported to elicit humoral and cellular immune response in both experimental animals and @entity1 . These autoantigens are expressed within @entity731 . Immunization with the given autoantigens elicits an immune response that influences lesion progression. @entity731 susceptibility can be transferred by autoantigen-sensitized lymphocytes from immunized animals. @entity1 with @entity1252 ( @entity1252 ) and @entity1701 ( @entity1701 ) have a high risk for @entity65 events. The traditional risk factors fail to fully account for accelerated @entity731 in @entity1252 and @entity1701 . Immunological alterations, such as antibodies to oxidized LDL, antiphospholipid antibodies (aPL), antibodies to beta-2 Glycoprotein (anti- @entity2263 -GPL), anti-prothrombin antibodies, may play a role in premature @entity731 in @entity1252 and @entity1701 . Paraoxonase ( @entity533 ) is an enzyme with antioxidant activity attached to the circulating high-density lipoprotein (HDL) in plasma. Its function is to prevent oxidation of LDL, thereby accounting for the antioxidant properties and the atherosclerotic protective effects of HDL. The relationship between @entity533 and aPL has been recently suggested. IgG anti-HDL and IgG anti- @entity9500 antibodies were associated with reduced @entity533 activity in @entity1 with @entity1252 and primary @entity1701 . The determination of classic and new factors, together with specific autoantibody titers and the use of Doppler carotid ultrasound, are useful methods to detect early @entity731 in @entity1252 and PAPS. Therapeutic strategies, including early control of disease and other risk factors, are essential to reduce morbidity and mortality.
