Inflammatory Factor Alterations in the Gastrointestinal Tract of Cocks Overexposed to XXXX .

@entity1 @entity4447 @entity9188 @entity47626 @entity310 @entity3623 @entity3494 @entity2247
UNASSIGNED: Exposure of @entity1 and animals to @entity3494 (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and @entity4447 ( @entity9188 ) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of the gastrointestinal tract in birds exposed to @entity9188 . To investigate the possible correlation of @entity9188 with inflammatory injury induced by an @entity3494 -supplemented diet in birds, 72 1-day-old male Hy-line cocks were selected and randomly divided into four groups. They were fed with either a commercial diet or an @entity3494 -supplemented diet containing 7.5, 15, and 30  mg/kg @entity9188 . The experiment lasted for 90  days, and samples of gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum were collected at days 30, 60, and 90 of the experiment period. The inflammation-related genes were determined, including NF-kB, @entity3623 , @entity2247 , @entity47626 , and @entity310 . The connection between @entity3494 dosage and inflammation-related genes was assessed. The content of @entity3623 ( @entity3623 ) was measured by Western blot of the samples. The results showed that @entity3494 supplementation increased the mRNA expression levels of inflammation-related genes in the gastrointestinal tract of cocks at different time points (p   <   0.05). Moreover, the expression of the tissue and organ injury-related gene @entity3623 was upregulated (p   <   0.05). These data suggest that As induces the inflammatory response and may trigger digestive function regression of the gastrointestinal tract by affecting inflammation-related genes and @entity3623 in cocks. This study offers some information on the mechanism of gastrointestinal tract inflammatory injury and @entity3623 expression level alterations induced by arseniasis.
