Mechanism of @entity7051 activation of XXXX cyclase.

@entity3007 @entity6370 @entity1920 @entity12831 @entity7051 @entity35 @entity1388
@entity7051 activation of @entity35 liver plasma membrane @entity1920 cyclase has been examined and compared with the effect of glucagon, Gpp(NH)p and @entity1388 . Glucagon does not stimulate the detergent solubilized enzyme though @entity7051 , @entity1388 , and @entity12831 are effective in this regard. The stimulatory effects of either @entity1388 or @entity7051 are additive with those of @entity3007 and do not require @entity6370 to evoke their activation. Neither @entity1388 nor @entity7051 can substitute for @entity3007 when glucagon is the activator of @entity35 liver adenyl cyclase. The stimulatory effects of either ion on @entity1920 cyclase are additive with that produced by glucagon. Activation of @entity1920 cyclase by either @entity7051 or @entity1388 occurs by a mechanism distinct from that of glucagon or @entity6370 . The data presented her suggest that @entity1388 and @entity7051 may act via in a similar mechanism of action. Neither ion displays a lag in activation of @entity1920 cyclase. The pH profiles of @entity1388 and @entity7051 -stimulated @entity1920 cyclase activity are similar, and distinct from @entity6370 -stimulated activity. Cholera toxin treatment of @entity1920 cyclase blocks @entity1388 and @entity7051 stimulation of the enzyme to the same extent, while enhancing the activation obtained with @entity3007 and hormones.
