Biochemical alterations in cerebrospinal fluid during thoracoabdominal aortic cross-clamping in XXXX .

@entity63 @entity235 @entity602 @entity2759 @entity880 @entity451 @entity413
@entity602 during and after thoracoabdominal aortic cross-clamping continues to be a major problem. Somatosensory and motor evoked potentials have been used to monitor spinal cord function but their value for predicting @entity451 has been controversial. The aim of this study was to measure biochemical markers in the cerebrospinal fluid (CSF) and correlate changes with @entity2759 . Since neural tissue utilizes only @entity413 as substrate for its metabolism and energy supply, we measured changes of metabolites of anaerobe glycolysis. In a @entity235 model in which general anesthesia was used, the thoracoabdominal aorta was cross-clamped proximally and distally for 60 min. Hemodynamic parameters, blood gases, and @entity413 level were monitored continuously. Blood and CSF sampling were performed at baseline, at 15, 30, and 55 min during cross-clamping, and at 5 and 15 min after aortic declamping. Levels of @entity880 (1.7 +/- 0.1 to 3.2 +/- 0.3 mmol/L), pCO2 (43 +/- 2 to 35 +/- 1.6 mmHg), and neuron-specific enolase (NSE) (5.17 +/- 0.5 to 13.0 +/- 3.5 mg/L) in CSF showed significant changes (p < 0.05) during clamping and reperfusion. Changes in CSF @entity880 and NSE levels correlate with the duration of @entity2759 . These markers of @entity63 metabolism appear suitable to monitor the degree of @entity2759 during thoracoabdominal cross-clamping and may be useful to predict the efficacy of preventive methods.
