High-density lipoprotein particle concentration and subclinical XXXX of the carotid arteries in Japanese @entity1 .

@entity1 @entity6 @entity301 @entity2998 @entity731 @entity65 @entity165
OBJECTIVE: The association of high-density lipoprotein particle (HDL-P) with @entity731 may be stronger than that of HDL- @entity165 (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of @entity301 ( @entity301 ) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese @entity1 , who characteristically have higher HDL-C levels and a lower @entity301 burden than those in @entity1 of Western populations. METHODS: We cross-sectionally examined a community-based sample of 870 Japanese @entity1 aged 40-79 years, free of known clinical @entity65 ( @entity65 ) and not on lipid-lowering medication. @entity1 were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. RESULTS: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional @entity301 risk factors, including low-density lipoprotein @entity165 (LDL-C) and @entity6 . HDL-P maintained an association with cIMT after further adjustment for HDL-C (P  <  0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. CONCLUSION: HDL-P, in comparison to HDL-C, is more strongly associated with measures of @entity2998 in a cross-sectional study of Japanese @entity1 . Findings demonstrate that, HDL-P is a strong correlate of subclinical @entity731 even in a population at low risk for @entity301 .
