Smoking is a predictor of adverse pathological features at radical prostatectomy: Results from the Shared Equal Access Regional XXXX Hospital database.

@entity1 @entity263 @entity5
OBJECTIVE: To test the relationship of smoking and @entity263 in @entity1 undergoing radical prostatectomy. METHODS: A retrospective analysis of 2290 @entity1 who underwent radical prostatectomy from the Shared Equal Access Regional @entity5 Hospital database from 2000 to 2013 was carried out. There were 1592 (70%) non-smokers and 698 (30%) smokers at radical prostatectomy. Logistic regression was used to examine whether smoking predicted Gleason score (>= 4   +   3), margin status, extracapsular extension or seminal vesicle invasion. Linear regression was used to test the relationship between smoking and @entity5 volume. RESULTS: Smokers were younger, more likely to be black, had lower body mass index, higher pathological Gleason score, more positive margins and extracapsular extension (all P   <   0.05) versus non-smokers. On crude analysis, smoking was associated with positive margins (odds ratio 1.32; P   =   0.003) and extracapsular extension (odds ratio 1.26; P   =   0.036). After adjusting for multiple clinical factors, smoking remained associated with a 19-35% increased risk of every adverse feature studied, though only the association with extracapsular extension reached significance. On multivariable analysis, a trend for smokers to have larger @entity5 volumes (geometric mean 5.8 vs 5.3   g; P   =   0.062) was found. CONCLUSIONS: In @entity1 undergoing radical prostatectomy, there seems to be a trend for smokers to have worse pathological features compared with non-/former smokers. If confirmed in future studies, smoking should be considered a modifiable risk factor for @entity263 .
