Growth and hormonal content of XXXX fetal pancreas passaged in athymic @entity19 .

@entity1 @entity2690 @entity19 @entity413
While the usefulness of the @entity1 fetal pancreas transplanted into diabetic @entity1 has yet to be realized, its transplantation into @entity19 has revealed some of its potential. In this animal the organ grows in size, during which time differentiation of its endocrine component and maturation of the insulinogenic response to @entity413 occurs. The results reported in this article expand these results by providing data on the weight and both the @entity2690 and glucagon content of these passaged organs. @entity1 fetal pancreata of gestational age 14-19 wk were implanted subcutaneously (s.c.) in @entity19 and maintained in vivo for 5-54 wk (absolute age 19-68 wk). The implants were then removed and their @entity2690 and glucagon content determined. Both the weight of these implants and their @entity2690 content were positively correlated with the absolute age of the tissue (weight: r = 0.61, P less than 0.001; @entity2690 content: r = 0.62, P = 0.0003). The glucagon content bore no relationship to the age. The maximum level of @entity2690 extracted from 30 passaged @entity1 fetal pancreata was 0.8 U, a level far below the daily @entity2690 requirements in adult @entity1 . It is suggested that an explanation for this is the site of transplantation used. To compare the s.c. site with the renal subcapsular space, the explants of four fetal pancreata were evenly divided between these two sites. After 11-13 wk, the implants were removed. Those beneath the renal capsule were larger and contained a greater amount of @entity2690 and glucagon than those transplanted s.c.(ABSTRACT TRUNCATED AT 250 WORDS)
