Increased level of soluble interleukin-2 receptor in advanced XXXX : a preliminary study.

@entity1 @entity0 @entity706 @entity5 @entity3 @entity2902
Both activated normal and transformed lymphocytes produce not only cell-associated but also cell-free @entity2902 . Evidence of high serum concentrations of @entity2902 appears to serve as a @entity5 marker in @entity1 with @entity706 On the contrary, the role of soluble @entity2902 in solid @entity5 has still to be defined. This investigation was carried out to analyze soluble @entity2902 production in @entity1 @entity5 . The study included 35 @entity1 with @entity5 (12 without and 23 with @entity3 ), 58 healthy subjects and 6 @entity706 @entity1 . Among @entity5 @entity1 , lung and @entity0 were the two most frequent @entity5 . In each subject or patient, serum levels of @entity2902 were measured by using an enzyme immunoassay. Moreover, in 14/23 @entity1 with metastatic @entity5 , lymphocyte subpopulations were also evaluated. Serum levels of @entity2902 were significantly higher in the @entity5 @entity1 than in the normal subjects. The @entity1 with metastatic @entity5 showed significantly higher mean levels than those without @entity3 , and similar to those observed in the @entity706 @entity1 . Finally, there was no correlation between serum levels of @entity2902 and the T4/T8 ratio, which was reduced in 5/14 @entity5 @entity1 . Further studies will be needed to establish if elevated concentrations of @entity2902 in the serum can contribute to the immunoincompetence of @entity1 with disseminated solid @entity5 .
