Early diagnosis of XXXX in non-neutropenic critically ill @entity1 .

@entity1 @entity7408 @entity4963 @entity7553 @entity5132 @entity3 @entity375
OBJECTIVE: To determine a method for the early diagnosis of @entity7553 in non-neutropenic critically ill @entity1 in order to reduce mortality. METHODS: A prospective study in non-neutropenic critically @entity1 in whom Candida spp. were detected, was made in an intensive care unit (ICU) during an 8-year period from 3389 @entity1 admitted. A diagnostic and therapeutic protocol was designed. @entity3 was defined according to dissemination and multifocality. RESULTS: Candida spp. were found in 145 cases (4.3%): 120 (83%) were considered as @entity3 and 25 as colonisation (17%). The hospital mortality was 46% (67/145). A post-mortem study was carried out in 54% (36/67) of hospital deaths. @entity5132 was the most frequently isolated species (87%), followed by @entity7408 (18%). There were 24 @entity4963 and three cases of endophtalmitis. Digestive and respiratory samples and non- @entity5132 @entity375 were risk factors for @entity3 . The mortality rate was related statistically to @entity3 and inversely to the appropriate antifungal treatment. CONCLUSIONS: @entity3 is related to digestive and respiratory samples and to the presence of non- @entity5132 species. A simpler definition of @entity3 in non-neutropenic critically ill @entity1 will permit more rapid and accurate specific antifungal therapy.
