Pulmonary prostacyclin is associated with less severe XXXX in preterm @entity1 .

@entity1 @entity2404 @entity649 @entity26 @entity95 @entity7489 @entity651 @entity4770 @entity2107 @entity3352 @entity9077
BACKGROUND: Prostacyclin (PGI(2)) and @entity2404 (TxA(2)) may take part in lung pathology; high concentrations of PGI(2) may protect newborn @entity95 against @entity651 , and TxA(2) may participate in the development of @entity2107 ( @entity2107 ). AIMS: To examine in small preterm @entity1 , the relationship between pulmonary PGI(2) and TxA(2) and @entity649 during the early postnatal period. METHODS: The stable metabolite of @entity4770 , @entity9077 , and that of @entity2404 , @entity7489 , were quantified by radioimmunoassays in 284 samples of tracheal aspirates from 48 @entity1 (GA: 27.4+/-2.1 week, BW 959+/-334 g) during the first 12 postnatal days. RESULTS: Mean concentration of @entity9077 was 414+/-31 pg/ml (mean+/-S.E.M.), and of @entity7489 was 418+/-37 pg/ml. Correlations existed between @entity9077 and gestational age, birth weight, and the initial arterial-alveolar oxygenation ratio. Negative correlations existed between @entity9077 and both mean inspiratory @entity26 and duration of mechanical ventilation. @entity3352 treatment was associated with lower pulmonary @entity9077 , but not with lower TxB(2). @entity7489 correlated positively with gestational age, birth weight, and initial arterial-alveolar oxygenation ratio, and inversely with duration of mechanical ventilation. CONCLUSIONS: In preterm @entity1 , higher pulmonary @entity9077 was associated with less severe @entity649 and with maturity, whereas @entity7489 was associated more strongly with maturity than with @entity649 .
