Pulmonary manifestations of vinyl and XXXX (interstitial lung disease). Newer aspects.

@entity1 @entity286 @entity7398 @entity2634 @entity1887 @entity2 @entity5244 @entity358
Newer varieties of occupational @entity358 primarily due to the vast increase in industrial technology have been reported recently. Preeminent among such newer agents are @entity7398 (VC) and @entity2634 . Very few cases have been reported, in Europe only, with descriptive histopathologic changes. To our knowledge, no pathologic studies of VC exposure have been described in the American literature. The biopsy abnormalities in our @entity1 disclosed desquamation of alveolar macrophages into the alveolar lumina and minor interstitial and alveolar inflammatory changes. Pulmonary function abnormalities included @entity1887 . Preventive therapy consists of the avoidance of further exposures, frequent industrial hygiene monitoring, and total avoidance of @entity286 smoke, as well as associated atmospheric pollutants. Thus far, none of these @entity1 has exhibited evidence of @entity2 . All three @entity1 survived their occupational injuries, and two are still disabled to varying degrees. Urine and blood levels of @entity5244 derivatives were elevated in two @entity1 , the exact significance of which is not fully known. It probably represents a toxicologic response, but must be further pursued before conclusions can be reached.
