Cerebrospinal fluid involvement in XXXX .

@entity1 @entity5 @entity2617 @entity854 @entity1073
@entity1073 ( @entity1073 ) is an aggressive @entity5 that is incurable by standard therapy. @entity1 often present with high-stage disease (Stages III-IV) and frequently have involvement at multiple extranodal sites. Although the gastrointestinal tract, spleen, lung, pleura, bone marrow, and peripheral blood are among the most commonly involved tissues, @entity1073 may also disseminate to so-called sanctuary sites including the central nervous system. Despite this, current clinical evaluations do not routinely include assessment of the cerebrospinal fluid (CSF) for @entity2617 at presentation, and moreover, only few authors have specifically examined CSF involvement in @entity1073 . In this study, we reviewed the medical records of 108 @entity1 with @entity1073 seen at three centers over a 5-year period to determine the rate of CSF sampling and the frequency of CSF involvement by @entity1073 . The clinical and cytologic characteristics associated with CSF involvement were also studied. Central nervous system (CNS) signs and/or symptoms prompted CSF sampling in 25/108 @entity1 (23%). Specific @entity854 were present in 9/25 @entity1 (36%). CSF involvement by @entity1073 was identified in 10 of the 25 CSF-sampled @entity1 (40%) by morphology (3 @entity1 ), flow cytometry alone (1 @entity1 ), or both (6 @entity1 ). The CSF-positive cases included two blastoid variants. The CSF cytology of the nine morphologically positive cases was pleomorphic, and prominent cytoplasmic granules were observed in two cases. The overall rate of CSF involvement by @entity1073 among the cohort was 9%, which is comparable to that reported in other selected studies examining this issue.
