Radioactive treatment of a @entity19 @entity320 using a XXXX -patch.

@entity7263 @entity19 @entity5 @entity1711 @entity1710 @entity320
OBJECTIVE: To evaluate the therapeutic effects of a @entity7263 -patch in the treatment of a @entity19 @entity320 . MATERIALS AND METHODS: Thirty male C57BL6 @entity19 were divided into two groups: treated and control. Superficial @entity5 were induced in both groups by injecting B16F1 @entity320 at about 10 cells/ @entity19 subcutaneously. @entity5 developed 10-15 days after transplantation and the @entity7263 -patch was applied on palpable @entity5 of the treated group. @entity5 growth was followed up in both groups by measuring @entity5 size with a caliper. After the follow-up period, the animals were killed and @entity5 samples of the treated and control groups were collected for histological study by preparing paraffin sections stained with @entity1710 - @entity1711 . RESULTS: The @entity7263 -patch showed the absence of radioactivity leakage in vitro and the homogeneous distribution of the radionuclide. The skin surface at the application site of the @entity7263 -patch appeared hairless, and erythema developed, but reversed to normal after a few days in the treated group. Control of @entity5 growth was achieved in the treated group compared with the control group, although complete remission did not occur. CONCLUSION: The @entity7263 -patch tested for the treatment of a @entity19 @entity320 model showed its efficacy, as @entity5 growth was retarded after application of the patch Nevertheless, adjustment of some therapeutic parameters and/or combining the patch with other treatment modalities may be necessary to achieve complete regression. The P-patch represents a powerful tool to individualize the treatment of @entity320 .
