Adrenal Function Testing Following Hormone Therapy for XXXX : Case Series and Review of Literature.

@entity1 @entity4545 @entity1887 @entity739 @entity701 @entity617 @entity774
@entity617 and @entity4545 ( @entity4545 ) are "hormone" therapies for @entity739 . There is limited data on the occurrence of decreased adrenal reserve or signs of clinical @entity1887 after hormone therapy. This is a retrospective medical record review of @entity1 referred to our @entity739 Program. Our standardized @entity739 management guideline began in September 2012 and initially included a post-hormone laboratory assessment of adrenal function. Medical records were assessed for hormone treatments, adrenal function testing, and signs of @entity1887 . Forty-two @entity1 who received one or both hormone therapies met inclusion criteria. A post-hormone laboratory assessment of adrenal function was done in 14 @entity1 . Of these 14 @entity1 , 2 had an abnormal laboratory assessment of adrenal function, both by adrenal stimulation testing   -   one after @entity4545 and one after @entity617 . One @entity1 received @entity701 replacement and the other received stress dose @entity701 as needed; neither @entity1 developed signs of @entity1887 . Another @entity1 treated with both types of hormone therapy in tandem, who did not have a post-hormone laboratory assessment, developed signs of mild @entity1887 and required replacement @entity701 . Our study suggests that adrenal suppression can occur after modern hormone therapy regimens. We found two @entity1 with abnormal adrenal function testing after hormone therapy and another @entity1 with signs @entity1887 . Given the seriousness of @entity774 , caregiver education on the signs of @entity1887 is critical. Greater vigilance may be indicated in @entity1 receiving both types of hormone therapy in tandem. Although a routine post-hormone laboratory assessment of adrenal function may not be feasible in all @entity1 , replacement or stress dose @entity701 is necessary for all @entity1 with suspected @entity1887 .
