Trends in Antiepileptic Drug Prescriptions for Childhood @entity302 at a Tertiary XXXX 's Hospital in Korea, 2001-2012.

@entity1 @entity4677 @entity2812 @entity5762 @entity2682 @entity2051 @entity5305 @entity1092 @entity10315 @entity4481 @entity109 @entity302 @entity3174 @entity1771 @entity13876 @entity17979 @entity2049 @entity734
OBJECTIVES: Longitudinal prescription patterns of @entity734 ( @entity734 ) have not been described to date in Korea. Here we aimed to describe AED prescribing trends over a 12-year period and assess age differences in AED prescribing patterns in a @entity302 . METHODS: We retrieved and analyzed all AED prescribing and dispensing data in 2001-2012 in @entity1 aged 0-18  years with an established diagnosis of @entity302 at the largest tertiary @entity1 's hospital in Korea. @entity734 included for analysis were classified as older (i.e., @entity2049 , @entity17979 , @entity109 , @entity3174 , and @entity1092 ) and newer (i.e., @entity2682 , @entity2812 , @entity4677 , @entity2051 , @entity4481 , @entity1771 , @entity5305 , @entity10315 , @entity13876 , and @entity5762 ) on the basis of market availability before versus after 1991. RESULTS: A total of 5593 @entity1 with @entity302 were prescribed an AED during the 12-year period. The proportion of newer AED prescriptions was 52.6  % in 2001 and continuously increased to 74.3  % in 2012. @entity2051 was most widely used, followed by @entity1092 . While @entity2049 and @entity5305 use progressively decreased over the 12-year period, those of @entity2812 and @entity1771 rapidly increased. Age differences in prescribing patterns were observed. Polytherapy was observed in 49.7  % of the total population, while 83.9  % of new users were prescribed monotherapy. CONCLUSION: This study provided updated information on AED prescription trends for childhood @entity302 . We found a progressive increase in the use of newer @entity734 . However, @entity1092 , the only prevalent older AED, continued to be widely prescribed. A high rate of polytherapy among the prescriptions overall raises some safety concerns.
