Nicotinic cholinergic receptor expression in the XXXX nasal mucosa.

@entity1 @entity1244 @entity286 @entity825 @entity1127 @entity146 @entity1239 @entity1093 @entity537 @entity6786 @entity2263
Twenty-four nasal mucosa specimens were obtained from the inferior or middle turbinates of 6 normal subjects and 18 @entity1 with chronic @entity1244 , @entity1127 . Reverse transcription-polymerase chain reaction analysis was used to identify the @entity6786 ( @entity6786 ) subunits that were expressed in the nasal mucosa. Collectively, transcripts for @entity2263 , @entity537 ) @entity6786 subunit genes were detected in the respiratory mucosa. The alpha3, alpha7, and @entity2263 subunits were expressed in 92%, 88%, and 75% of the subjects, respectively. There was a high degree of interindividual variation in @entity6786 subunit gene expression among subjects. A significant univariate association was found between tissue type and @entity537 expression and between gender and @entity1093 expression. These data suggest that cells in the nasal mucosa express the necessary messenger RNAs (mRNAs) for numerous @entity6786 combinations. Moreover, our identification of @entity6786 subunit mRNAs in the nasal mucosa extends the findings of other functional studies of nAChRs in nasal epithelial cells and implies that @entity1239 from @entity286 products such as cigarette smoke and @entity1239 nasal spray may have direct cellular effects on nasal mucosa cells through activation of homogeneous or heterogeneous nAChRs. A significant number of @entity1 receiving @entity1239 nasal spray have reported nasal irritation, and there are reports of transient @entity146 and @entity825 with the use of smoke-free @entity1239 cigarettes. These adverse respiratory effects may be due to activation of nAChRs in epithelial cells of the nose and @entity825 .
