Effect of urinary tract @entity281 on ureteropelvic junction obstruction in a XXXX model.

@entity32 @entity8 @entity1494 @entity3885 @entity3041 @entity793 @entity281 @entity35 @entity526
OBJECTIVES: When a partially obstructed kidney becomes infected, more rapid and extreme renal parenchymal damage appears to occur than might result from either @entity281 alone. Previously, we showed that either @entity793 or @entity3885 in congenital unilateral @entity3041 causes @entity8 in a @entity35 model. In this same model, we examined the combined effects of partial upper tract obstruction and @entity1494 . METHODS: Female @entity35 from an inbred colony in which more than one half are born with unilateral obstructive @entity3041 were studied. Type 1 piliated @entity526 was instilled into the bladder. Two to 6 days later, the @entity1494 were measured during varying urinary flows (less than 2 to more than 30 mL/kg/hr). All animals were killed and the kidneys and bladder grossly and histologically assessed. @entity3041 was determined at pathologic examination. RESULTS: Eight @entity35 had congenital unilateral @entity3041 ; five were normal. Acute @entity32 was found in all bladder and renal specimens. In @entity8 exceeded those in nonhydronephrotic, infected kidneys at all urinary flow rates. Bladder capacity and pressures did not differ between the two groups. CONCLUSIONS: This model demonstrates that the combination of @entity281 and obstructive @entity3041 in this model causes renal pelvic pressure elevation that is higher than that associated with either @entity281 or obstructive @entity3041 alone. These data demonstrate the compound effect that @entity281 may have on the kidney and offers an explanation for why this clinical situation is more likely to be associated with greater renal parenchymal injury than either alone.
