Prognostic factors and outcomes in primary @entity5 : results from the international collaboration on primary XXXX .

@entity1 @entity5 @entity957 @entity189 @entity4434 @entity420 @entity204 @entity1349
PURPOSE: To evaluate risk factors for survival in a large international cohort of @entity1 with primary @entity5 (PUC). METHODS: A series of 154 @entity1 (109 @entity1 , 45 @entity1 ) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free ( @entity4434 ) and @entity1349 ( @entity1349 ). Multivariate models were constructed to evaluate independent risk factors for recurrence and @entity204 . RESULTS: Median age at definitive treatment was 66  years (IQR 58-76). Histology was @entity189 in 72 (47  %), @entity957 in 46 (30  %), @entity420 in 17 (11  %), and mixed and other histology in 11 (7  %) and nine (6  %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p  <  0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4  %, respectively. In multivariable Cox-regression analysis for @entity1 staged cM0 at initial diagnosis, @entity4434 was significantly associated with clinical nodal stage (p  <  0.001), @entity5 location (p  <  0.001), and age (p  =  0.001), whereas clinical nodal stage was the only independent predictor for @entity1349 (p  =  0.026). CONCLUSIONS: These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
