SNPs in the XXXX gene region show no association with @entity2023 in a Han Chinese population.

@entity1 @entity2023 @entity402 @entity56 @entity9416 @entity220
BACKGROUND: @entity9416 ( @entity9416 ) is a central player in the @entity56 response, and raised total @entity9416 levels are considered as an indicator of @entity402 or potential development of @entity402 . A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for @entity9416 ( @entity220 ) as a susceptibility locus influencing total serum @entity9416 levels. The aim of this study was to investigate whether the polymorphisms in the @entity220 gene are associated with @entity2023 ( @entity2023 ) in a Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: A population of 378 @entity1 with @entity2023 and 288 healthy controls was studied. Precise phenotyping of @entity1 was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum @entity9416 ( @entity9416 ) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in @entity220 were selected and individually genotyped. None of the SNPs in the @entity220 showed an association with @entity2023 . Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in @entity220 was associated with total @entity9416 level. CONCLUSIONS: Although @entity220 presents itself as a good candidate for contributing to total serum @entity9416 , this study failed to find an association between SNPs in the @entity220 gene region and @entity9416 level or @entity2023 susceptibility.
