The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in @entity191 XXXX .

@entity1 @entity23 @entity146 @entity191
BACKGROUND: At least 14% of @entity191 ( @entity191 ) @entity1 develop @entity23 ( @entity23 ). The pathophysiology behind these behaviors and the impact of deep brain stimulation in a real-life setting remain unclear. OBJECTIVES: We prospectively examined the impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on @entity23 in @entity191 @entity1 , as well as the relationship between impaired sensorimotor gaiting and impulsivity. METHODS: @entity1 undergoing bilateral STN-DBS were assessed for @entity23 preoperatively and 1-year postoperatively using a validated questionnaire (QUIP-RS). A subset of @entity1 completed the Balloon Analogue Risk Task (BART) and auditory prepulse inhibition (PPI) testing. RESULTS: Analysis revealed 12 @entity1 had an improvement in score assessing @entity23 ('good responders'; p = 0.006) while 4 had a worse or stable score ('poor responders'; p > 0.05). Good responders further exemplified a significant decrease in @entity146 (p = 0.005) and binge eating (p = 0.01). Impaired PPI responses also significantly correlated with impulsivity in BART (r = -0.72, p = 0.044). DISCUSSION: Following bilateral STN-DBS, 75% of our cohort had a reduction in @entity23 , thus suggesting deep brain stimulation effectively manages @entity23 in @entity191 . The role of impaired PPI in predisposition to @entity23 in @entity191 warrants further investigation.    2015 S. Karger AG, Basel.
