Assessing long-term effects of XXXX on lipid metabolism profile, @entity1372 values and liver function tests.

@entity1 @entity2051 @entity2299 @entity16098 @entity1674 @entity1372 @entity71518 @entity165 @entity302 @entity13953 @entity2049 @entity2753 @entity23100
INTRODUCTION: Older @entity71518 with a @entity16098 substitution have been demonstrated to cause deleterious effects on lipid metabolism profile, as well as frequent @entity2753 . The aim of our study is to assess the effects of @entity13953 , a novel AED, on lipid metabolism profile, @entity1372 values and liver function tests, as well as to compare them with previous effects of @entity2049 and @entity2051 . METHODS: This report describes a retrospective cohort study of 108 @entity1 who were treated with @entity23100 . Of these @entity1 , 52% had switched to @entity23100 from prior treatment with @entity2049 or @entity2051 . Laboratory values concerning lipid metabolism profile, liver function tests and @entity1372 were assessed before and after beginning/switching treatment. @entity1 who began treatment or whose treatment for @entity2299 was modified during the study period were excluded from the analysis. Co-medications that could impact lipid metabolism profile, @entity1372 or hepatic function were kept stable during the study period. RESULTS: The mean total @entity165 of the entire group decreased significantly from prior pathological to normal values after beginning/switching treatment. The percentage of @entity1 with pathological values decreased. @entity1 switching from prior @entity16098 also showed significant reductions in mean LDL and @entity1674 . @entity1 beginning treatment without prior @entity16098 did not develop @entity2299 after titration. A tendency for an increased percentage of @entity1 with @entity2753 was detected in both groups. CONCLUSIONS: Compared with older @entity16098 , @entity13953 exhibits a safer profile related to lipid metabolism. No relevant changes were detected in liver function tests. Consequently, a vascular risk factor could be avoided in @entity1 with @entity302 , while @entity2753 still needs to be ruled out. Prospective studies are still needed.
