Early blunted XXXX response to insulin induced hypoglycaemia in familial Mediterranian fever.

@entity1 @entity4545 @entity32 @entity827 @entity1691 @entity701 @entity1851
OBJECTIVE: To study @entity701 , @entity4545 and @entity1851 responses to specific stimuli in @entity827 ( @entity827 ). METHODS: For the purpose of measuring @entity701 , ACTH, and @entity1851 responses to insulin induced hypoglycaemia during attack-free periods, 14 @entity827 @entity1 , 11 @entity1 with @entity1691 or Beh  et's disease as disease controls (DC), and a further 10 healthy control subjects (HC) were involved in this study. None of the subjects had ever received corticosteroids before this study. @entity701 and ACTH levels were measured by chemiluminescence enzyme immunoassay. RESULTS: No attack was observed among @entity827 @entity1 during the test. No significant difference in the mean @entity701 values after insulin induced hypoglycaemia was observed between the groups involved at any stage of the test. The integral @entity701 response to hypoglycaemia expressed as the AUC (0-90 min) was found not to differ among the study groups (1827 +/- 115.6 in @entity827 ; 2196 +/- 205.4 in DC, p = 0.12; 1771 +/- 98.4 in HC, p = 0.9). The delta response of @entity701 to insulin induced hypoglycaemia wasfound to be statistically lower (-4 +/- 0.8 mg/dl vs. -1.9 +/- 0.7 microg/dl; p<0.03) only for the 0 to 30 min interval in @entity1 with @entity827 compared to HC respectively. Similar results, though of no statistical significance, were also found for the 0 to 45 min interval (1.17 +/- 2.2 microg/dl in @entity827 @entity1 vs. 3.3 +/- 2 microg/dl in HC; p = 0.6). The mean basal @entity1851 level of @entity1 with @entity827 was remarkably higher than that in HC. Although the mean @entity1851 level at 90 min for @entity827 cases with @entity701 levels under 12 microg/dl at 30 min was found to be higher than those with @entity701 levels over 12 microg/dl at 30 min, no significant difference was observed. CONCLUSION: An early blunted @entity701 response observed in a stressful situation in @entity827 @entity1 may well account for the curious relationship between stress and an @entity32 . Furthermore, the fact that the @entity1851 level was relatively higher in @entity827 @entity1 with lower @entity701 levels might also highlight the importance of endogen @entity701 in the inflammatory feature of this disease.
