Use of dextran-primed extracorporeal circuit in the XXXX model for venous return: with special references to the effects of two dihydropyridine-type Ca2+ channel blockers.

@entity1242 @entity235 @entity1405 @entity10129 @entity594 @entity1063 @entity551
1. A successful @entity235 "venous return (VR)" model is described, in which all hemodynamic parameters were stable for about an hour, by minimizing extracorporeal circuit primed with dextran (DX) so that the dilution of the blood was kept about 33%. 2. Increases in VR by @entity1063 (1 micrograms/kg) and dose-dependent decreases in VR by @entity1242 (1-30 micrograms/kg) were clearly observed. 3. While 1 microgram/kg of @entity594 produced a small, but significant decrease in VR, only a tendency for decrease was observed with higher doses which produced a @entity551 . 4. @entity10129 (1 microgram/kg) caused a small decrease in VR. However, higher doses that produced a large and persistent @entity551 produced an increase in VR due probably to intense reflex translocation of the blood. The increase in VR was reversed with @entity1405 , a beta-blocker with alpha-blocking activity.
