A persistently high body mass index increases the risk of XXXX at  school age.

@entity1 @entity565 @entity12131 @entity56
AIM: Being overweight has been associated with the risk of developing @entity565 , but studies have produced conflicting results, for example with regard to possible links to @entity56 . This study aimed to explore the relationship between body mass index (BMI) and school-age @entity565 . METHODS: Data were obtained from a prospective, longitudinal study of 5044 @entity1 born in western Sweden. The parents answered questionnaires at six months and one, four-and-a-half and eight years of age. The response rate to the final questionnaire at the age of eight was just over 80%. BMI was adjusted for age and gender, and a high BMI was defined as the 85th percentile and above. RESULTS: A multivariate analysis showed an independently increased risk of doctor-diagnosed @entity565 among @entity1 with a persistently high BMI, both in infancy and at school age, with an adjusted odds ratio (aOR) of 2.9 and a 95% confidence interval (CI) of 1.3-6.4. In addition, persistently high BMI was associated with an increased risk of @entity12131 (aOR 4.7, 95% CI 2.0-11.0). CONCLUSION: A persistently high BMI during childhood increased the risk of doctor-diagnosed @entity565 at school age. The increased risk of @entity12131 suggests an effect mediated via the immune system.
