Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in XXXX with Polymicrobial Sepsis.

@entity8 @entity1619 @entity19 @entity61 @entity630 @entity130
Background. This study evaluated the impact of different doses of Astragalus polysaccharides (APS) on the functional status and phenotype of T cells during polymicrobial sepsis. Methods. On day 1 after cecal ligation and puncture, @entity19 were treated with either saline, 100 (A100), 200 (A200), or 400   mg APS/kg body weight (BW) (A400) by an intraperitoneal injection daily for 4 days. All @entity19 were sacrificed 5 days after the operation. Results. APS treatment reversed the sepsis-induced @entity1619 helper (Th) cell population, and the percentage of activated Th cells also increased in the spleen and Peyer's patches. APS administration downregulated the percentages of circulating @entity61 cells and regulatory T cells (Treg), and the percentage of Th17 cells in blood was upregulated in the A400 group. @entity8 were attenuated in the A100 and A200 groups but not in the A400 group at the end of the study. Conclusions. Treatments with 100 and 200   mg APS/kg BW reduced Treg populations and elicited a more-balanced @entity630 / @entity61 response that consequently attenuated immunosuppression in polymicrobial sepsis. High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced @entity130 .
