XXXX in patients with antibody deficiency.

@entity1 @entity55 @entity6078 @entity1112 @entity465 @entity358 @entity764 @entity5924
OBJECTIVE: The aim of this study was to evaluate @entity358 in @entity1 with @entity465 ( @entity1112 [ @entity1112 ] and @entity6078 [ @entity6078 ]). METHODS: Thirty @entity1 over six years of age regularly followed in a reference out- @entity1 clinic on @entity465 were studied. All of them have been treated with intravenous immunoglobulin (IVIG) replacement therapy. @entity358 were evaluated analysing clinical data (medical records review), lung function test (spirometry) and pulmonary imaging (chest computed tomography [CCT]). RESULTS: @entity1 with normal CCT (N = 14) and those with abnormal CCT (N = 16) have shown no differences regarding the age at onset of symptoms, age of diagnosis, and duration of IVIG treatment. The mean number of @entity55 episodes before IVIG replacement was significantly higher among @entity1 with abnormal CCT (4 vs 7 episodes, p = 0.008). @entity764 observed in 16 @entity1 were: bronchiectasis (12/16); peribronchial thickening (3/16); air trapping (5/16); lung volume reduction (4/16); atelectasis (2/16), @entity5924 and ground-glass abnormality (2/16) and parenchyma nodule (1/16). Lung function tests showed ventilatory disturbance in 18/30: obstructive pattern in 38.8%, restrictive pattern in 44.4%, and mix pattern in 16.7%. There were no significant differences in lung function between those with and without @entity764 . Negative significant correlations were observed between lung function and number of episodes of @entity55 . Chronic persistent cough was associated with a @entity358 . CONCLUSIONS: @entity358 are not rare in patients with antibody deficiencies and they must be monitored.
