Paraoxonase and arylesterase activities in stent XXXX in bare metal stent.

@entity1 @entity407 @entity101 @entity75 @entity256 @entity453 @entity165
BACKGROUND AND OBJECTIVE: The serum paraoxonase and arylesterase activities are related to @entity453 . However, there are a few data about the association of paraoxonase and arylesterase activities with in-stent @entity256 (ISR). The aim of this study was to evaluate the relationship between paraoxonase and arylesterase activities and ISR in @entity1 with bare metal stent (BMS). MATERIALS AND METHODS: Thirty-one @entity1 with normal coronary artery (group 1) and 60 with BMS were enrolled in this observational study. According to the ISR, the @entity1 were classified as group 2, without the ISR (n=29) and group 3, with the ISR (n=31). Serum paraoxonase and arylesterase activities were measured spectrophotometrically. RESULTS: The paraoxonase and arylesterase activities were lower in @entity1 with BMS than in the individuals with normal coronary artery (P < 0.001 and P = 0.001, respectively). The enzyme activities were also higher in @entity1 without ISR than with ISR (both of P < 0.001). In bivariate correlation analyses in @entity1 with BMS, ISR shows significant positive correlations with the presence of @entity101 and @entity407 , @entity75 , and stent length, but shows negative correlations with @entity75 stent diameter, high-density lipoprotein @entity165 , and paraoxonase and arylesterase activities. In regression analysis, ISR is independently associated with paraoxonase and arylesterase activities (b = -0.216, P = 0.038 and b = -0.452, P < 0.001, respectively), @entity75 (b = -0.251, P = 0.013), and stent diameter (b = -0.192, P = 0.024) in @entity1 with BMS. CONCLUSION: Our study shows that decreased paraoxonase and arylesterase activities play a significant role in ethiopathogenesis ISR in @entity1 with BMS.
