Acute and chronic leptin reduces food intake and body weight in @entity2083 ( XXXX ).

@entity2661 @entity1017 @entity1735 @entity2083
The purpose of the present study was to elucidate the possible role of leptin in food intake and body weight regulation in @entity2083 . We examined the effects of i.c.v. or i.p. acute leptin administration on food intake in food-deprived @entity2083 at different time intervals post-injection (0-2, 2-8 and 0-8 h). Food intake was reduced by i.p. administered leptin (1 microg) at 8 h post-injection, without statistically significant differences after i.c.v. treatment. The present study shows for the first time in a teleost that chronic (10 days) leptin treatment (i.p.) reduces food intake, body @entity1017 , specific growth rate and food efficiency ratio. Moreover, lipid and @entity1735 metabolism seems to be regulated by leptin in fish. Chronic leptin treatment increased lipid mobilization and @entity1735 storage as hepatic and muscle glycogen. Finally, leptin could mediate its actions on energy homeostasis in fish, at least in part, through interactions with hypothalamic @entity2661 , since chronic leptin treatment reduced both hypothalamic noradrenergic and dopaminergic turnover without significant modifications in hypothalamic serotoninergic and neuropeptide Y (NPY) systems. In summary, our results suggest that leptin can regulate feeding behaviour and body weight homeostasis in fish.
