Serial volumetric assessment of the natural history and growth pattern of incidentally discovered XXXX .

@entity1 @entity75 @entity5 @entity10094 @entity1653
OBJECT: Due to advances in neuroimaging and the increasing use of imaging to screen for @entity75 ("brain checkups"), @entity1653 are now often detected as an incidental finding. The natural history of these @entity10094 remains unclear, however. In this study, the authors investigated the natural history and growth pattern of incidentally detected @entity1653 using serial volumetric assessment and regression analysis. METHODS: In 70 @entity1 with incidentally discovered @entity1653 who underwent follow-up for longer than 1 year, @entity5 volumes were calculated volumetrically at each follow-up visit, and @entity5 growth was determined. In @entity1 with @entity5 growth, regression analysis was performed to determine the pattern of growth. RESULTS: Forty-four @entity5 exhibited growth and 26 did not. In a regression analysis, 16 of the @entity5 that grew followed an exponential growth pattern and 15 exhibited linear growth patterns. The presence of calcification was the only imaging characteristic that significantly distinguished the group with @entity5 growth from that without, although no radiological characteristics significantly distinguished the exponential growth group from the linear growth group. Two @entity1 with obvious @entity5 growth underwent surgical removal and the pathological specimens extracted showed a high proliferative potential. CONCLUSIONS: The authors found that incidentally discovered @entity1653 did not always follow an exponential growth pattern but often exhibited more complex patterns of growth. Serial monitoring of @entity5 volumes and regression analysis may reveal the growth pattern of incidental @entity1653 and provide information useful for determining treatment strategy.
