Plasma and erythrocyte concentrations of free @entity1522 in adult @entity1 administered abuse doses of XXXX .

@entity1 @entity1522 @entity2227 @entity492 @entity815 @entity14006
Plasma and erythrocyte concentrations of @entity1522 were measured in 18 fasting adult subjects (9 male, 9 female) administered abuse doses of @entity14006 (100, 150, and 200 mg/kg body weight) dissolved in 500 ml orange juice. Six subjects were studied at each dose. Plasma @entity492 concentrations increased significantly (p less than or equal to 0.05) over baseline values after ingestion of each dose. However, the increase was small in each case, and maximal levels observed were below those noted postprandially in formula-fed @entity1 . No significant changes (p greater than 0.05) were noted in erythrocyte @entity2227 , or erythrocyte @entity492 concentrations after any dose. Plasma @entity815 concentrations increased significantly over fasting concentrations (p less than 0.01) from 15 min to 6 h after each dose, and the increase was proportional to dose. Mean (+/- SD) peak plasma @entity815 concentrations were 20.3 +/- 2.03, 35.1 +/- 11.3, and 48.7 +/- 15.5 mumol/dl, respectively, after @entity14006 doses of 100, 150, and 200 mg/kg. Erythrocyte @entity815 concentrations showed similar changes. Although these @entity815 concentrations are considerably above the normal postprandial range (12 +/- 3 mumol/dl), they are below values associated with toxic findings. These data indicate little risk to normal subjects from excessive @entity492 or @entity815 levels after ingestion of single abuse loads of @entity14006 .
