The Influence of Repeat Surgery and Residual Disease on Recurrence After Breast-Conserving Surgery: A Danish XXXX Cooperative Group Study.

@entity1 @entity3821 @entity0 @entity66 @entity5 @entity189
BACKGROUND: A significant proportion of @entity1 who have breast-conserving surgery (BCS) subsequently undergo re-excision or proceed to mastectomy. This study aimed to identify factors associated with @entity66 after repeat surgery and to determine their effect on ipsilateral @entity0 recurrence (IBTR) and survival. METHODS: The study cohort was identified within the national population-based registry of the Danish @entity0 Cooperative Group, including @entity1 who underwent BCS for unilateral invasive @entity0 between 2000 and 2009. RESULTS: The study investigated 12,656 @entity1 . Within 2 months after initial BCS, 1342 (11 %) of these @entity1 had a re-excision, and 756 (6 %) of the @entity1 had a mastectomy. @entity66 was found in 20 % of re-excisions and 59 % of mastectomies. In adjusted analysis, @entity3821 ( @entity3821 ) outside the invasive @entity5 , positive initial margin, and age younger than 50 years were associated with increased risk of @entity66 . In the adjusted analysis, @entity1 with @entity66 after re-excision had an increased risk of IBTR regardless whether residual findings were @entity189 [hazard ratio (HR), 2.97; 95 % confidence interval (CI) 1.57-5.62] or @entity3821 (HR, 2.58; 95 % CI 1.50-4.45). However, no difference was seen in overall survival comparing @entity1 receiving one excision with those having repeat surgery with or without @entity66 (p = 0.96). CONCLUSION: A higher risk of IBTR seen after re-excision was associated with @entity66 . Overall survival was similar regardless of repeat surgery and residual findings.
