[Sonographic changes in the size of the kidneys in type I diabetes as a method of early detection of XXXX ].

@entity1 @entity8 @entity6 @entity2316 @entity2262 @entity177 @entity1011
We carried out sonographic examination of 160 type I @entity6 measuring the renal volume, the parenchyma/renal pelvis index and the brightness of the parenchyma. @entity1011 and @entity2262 in the serum, @entity1011 clearance and albumin excretion by urine were determined as functional parameters. In contrast to existing results, we were unable to find significant changes in kidney size or function in newly diagnosed @entity6 (duration of @entity6 up to 6 months). Both the @entity8 were unchanged compared to control @entity1 of the same age. It was only if @entity6 lasted from 6 months to 5 years, that the renal volume was 19% larger (192 +/- 37 cm3/1.73 m2) than that of recently diagnosed @entity1 (p less than 0.01). The index had increased by 15%, whereas the @entity1011 clearance had increased by 18% to 121 +/- 27 ml/min as a result of increased perfusion. The renal volume decreased continuously over a five-year period of duration of @entity6 . Initially, microalbuminuria became manifest, followed some time later by a decrease in @entity1011 clearance and a corresponding increase in @entity1011 and @entity2262 in serum. No change in parenchyma brightness was noted. @entity6 with moderate @entity177 ( @entity1011 1.2 to 2 mg/dl) compared to @entity6 without insufficiency developed larger kidneys (207 cm3/1.73 m2; p less than 0.01). Only in case of severe insufficiency ( @entity1011 greater than 2 mg/dl) did the kidneys did shrink significantly (121 cm3/1,73 m2, n = 8, p less than 0.01). The temporary enlargement of the kidneys could be a prognostically unfavourable sign pointing towards a developing @entity2316 .
