Neurophysiological follow-up in two XXXX with @entity3605 after @entity1 growth hormone treatment.

@entity1 @entity9493 @entity989 @entity3605
A serial neurophysiological study has been performed of 2 @entity1 during the clinical course of @entity3605 after @entity1 growth hormone (hGH) treatment. Evolution of the EEG pattern was typical: slow waves, periodic sharp wave complexes, then extinction. VEP components were moderately altered. BAERs performed in only 1 @entity1 were normal. The blink reflex (BR) showed an early alteration of the R1 component. The @entity9493 exhibited early and profound anomalies. Pathological changes were obvious at the first recording, at the beginning of the second month after clinical onset: increase in peak latencies, morphological changes and important reduction of b wave amplitude (a/b amplitude ratio > or = 0.70; normal range 0.27-0.41). The @entity9493 was completely absent a few months later. These results are compared with the similar @entity989 described in @entity3605 - or scrapie-infected rodents. In the 2 @entity1 , pathological changes in @entity9493 and in BR were obvious several months before the development of the typical EEG pattern. Therefore, early @entity9493 and BR recording can be helpful in the diagnosis of @entity3605 , especially in this ataxic form following hGH treatment.
