Decreased uterine perfusion--a cause of XXXX .

@entity1 @entity249 @entity66
There have been several causes of @entity249 attributed to gamete quality, congenital anatomical @entity66 . Published research into the reasons for failure of implantation of embryos has been confined to histochemical and histological studies of the endometrium. This paper presents preliminary data from an ongoing study to test the hypothesis that poor uterine perfusion is a cause of failure of implantation of embryos. It would follow that poor uterine perfusion is a cause of @entity249 . One-hundred-and-fifty-three @entity1 who had been unsuccessful in conceiving despite three previous in-vitro fertilization attempts have been studied. Doppler ultrasound studies of the ascending branch of the uterine artery, during spontaneous ovarian cycles, revealed a poor mid-secretory uterine response in 48% of @entity1 studied. @entity1 with poor mid-secretory uterine response were treated with orally administered hormone therapy to improve the mid-secretory uterine response prior to subsequent embryo replacement. The results of subsequent in-vitro fertilization therapy in @entity1 with good uterine response and in @entity1 with improved uterine response after hormone therapy are presented. The numbers of @entity1 in each group are insufficient for statistical analyses, but the trends observed support the hypothesis that poor uterine blood flow is a cause of @entity249 . Further evaluation is warranted.
