XXXX and decline in cognitive function: The ONTARGET/TRANSCEND studies.

@entity1 @entity1032 @entity455 @entity6 @entity73 @entity633
BACKGROUND: Microvascular disease of the kidney (manifesting as @entity633 ) and of the brain (manifesting as @entity73 ) may share a common pathogenesis. Gaining an understanding of the concomitant history of these 2 conditions may inform clinical practice and lead to novel prevention and treatment approaches. METHODS: A total of 28 384 @entity1 with @entity455 or @entity6 were examined. At baseline and year 5, @entity1 underwent a @entity1032 ( @entity1032 ) and urine testing for albumin excretion. Multivariable logistic regression was used to determine the association between albumin excretion and @entity1032 score, cross-sectionally and prospectively, and whether angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker use modified the association. RESULTS: Compared with @entity1 with normoalbuminuria, those with microalbuminuria (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.11-1.44]) and macroalbuminuria (1.49; 1.20-1.85) were more likely to have a reduced @entity1032 score (<24). On follow-up, @entity1 with baseline @entity633 had increased odds of @entity73 (decrease in @entity1032 score >= 3 points) compared with those with normoalbuminuria (microalbuminuria: OR, 1.22; 95% CI, 1.07-1.38; macroalbuminuria: 1.21; 0.94-1.55). @entity1 who developed new @entity633 had increased odds of @entity73 during follow-up compared with those who remained normoalbuminuric (new microalbuminuria: OR, 1.30; 95% CI, 1.12-1.52; new macroalbuminuria: 1.77; 1.24-2.54). @entity1 with baseline macroalbuminuria treated with an angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker had lower odds of @entity1032 decline than @entity1 treated with placebo. CONCLUSION: Factors that contribute to @entity633 may contribute to @entity73 , supporting the notion that both conditions share a common microvascular pathogenesis. Trial Registration clinicaltrials.gov Identifier: NCT00153101.
