Accuracy of pepsinogens for early diagnosis of XXXX and @entity356 in Iranian population.

@entity1 @entity4726 @entity7598 @entity1534 @entity356 @entity7597
BACKGROUND: Currently, non-invasive methods for screening @entity4726 and @entity356 are lacking. The purpose of this study was to evaluate the value of serological parameters including serum @entity7597 ( @entity7597 ), @entity7598 ( @entity7598 ) and @entity7597 : II ratio for the screening @entity4726 and @entity356 . METHODS: The study population consisted of 132 dyspeptic @entity1 who had undergone upper endoscopy with biopsy. Blood samples for ELISA assays of serum @entity7597 , @entity7598 and IgG antibodies against @entity1534 were drawn. Comparison between the two groups was done by Student's t- test, and Mann Whitney test. Cut-off points were calculated using receiver operating curves (ROC). RESULTS: Mean (  SD) age of the study population was 51.4 (  15.5) years. Values of @entity7597 and PG ratio decreased significantly in the @entity4726 as compared with the control group (p<0.05). Values of PG and PG ratio didn't show any significant difference between the @entity356 and control group (p>0.05). For @entity1 with @entity4726 , the area under the ROC for @entity7597 was 0.639 (95% CI:0.538-0.741, p=0.008) in which the best cut-off value was 40 g/L (sensitivity 90%, specificity 67%, accuracy 69%, negative predictive value 92%, YI : 0.429). The area under the ROC for PG ratio was 0.711 (95% CI: 0.617-0.806, p=0.0001) and the best cut-off value was 8 (sensitivity 71%, specificity 71%, accuracy 71%, negative predictive value 86%,YI : 0.431). CONCLUSION: It seems that @entity7597 , @entity7597 : @entity7598 ratio is potential biomarkers for screening @entity4726 with high sensitivity, specificity, accuracy and negative predictive value. Serology could be used as a screening method for the detection of precancerous states due to its convenience, relative low cost and safety.
