A histopathological analysis of the epidemiology of XXXX : an autopsy study.

@entity1164 @entity1 @entity844 @entity1187 @entity39 @entity75 @entity406 @entity730 @entity453 @entity731 @entity165
BACKGROUND: @entity731 accounts for a large proportion of cardiovascular system associated morbidity and mortality. We studied the possible association between the histopathological changes of the @entity453 and the risk of @entity1164 ( @entity1164 ) using autopsy cases. METHODS: We performed an autopsy analysis (n   =   13, 4 @entity1 , 9 @entity1 mean age 67.5 years; age range 56-93 years) of @entity1164 which occurred in @entity1 aged over 50 years during March 2010 to December 2013. The following variables were considered: sex, age, medical history, autopsy findings to macroscopic and histological evaluation of the heart. The autopsies were performed according to standard techniques. In all subjects, the heart was dissected following standard autopsy protocol and a 5 cm section of the right coronary artery (RCA) in the atrio-ventricular groove from its origin, a 5 cm segment of the left anterior descending artery (LADA) distal to the origin of the circumflex artery, but including the region of origin of the circumflex branch and left coronary artery (LCA) from its origin till the circumflex branch were excised, dissected out, fixed in 10  % @entity406 , marked for identification and sent for histopathological analysis. RESULTS: @entity731 were identified in 6.5  % of specimens, 69.34  % of males and 30.66  % of female. Such plaques were typically concentric and more represented with @entity39 , @entity730 , @entity165 crystals, and giant cells, as well as had a higher inflammatory cell count. Furthermore, intima and media thickness of coronary arteries were significantly higher in studied specimens with visualize the connective tissue layers of the adventitia and the @entity844 containing adipose cells in the periadventitial tissue. Furthermore, the degree of @entity75 of @entity731 increased proportionally with the increase in the intensity of lipid deposition and with the percentage of collagen in the @entity731 . CONCLUSION: In this study, age estimate to be a risk factor for @entity453 in individuals more than 50 years old and may be used to predict @entity1164 . Altogether, an enhanced understanding of the pathobiologic processes responsible for @entity731 changes might allow for early identification of a high-risk coronary plaque and thereby provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary @entity1 and prevention of @entity1187 .
