Epidemiology of physician-diagnosed XXXX in childhood.

@entity1 @entity2023 @entity235 @entity565 @entity566 @entity2490 @entity56 @entity18249
OBJECTIVE: To investigate the natural history of and risk factors for @entity2023 in the first 6 years of life. METHODS: Parents of 747 healthy @entity1 followed from birth completed a questionnaire when the @entity1 was 6 years old. Data were obtained regarding physician-diagnosed @entity2023 (PDAR), associated symptoms, and age at onset. Risk-factor data were taken from earlier questionnaires, and data regarding immunoglobulin E (IgE) and skin-test reactivity were obtained at age 6. RESULTS: By the age of 6, 42% of @entity1 had PDAR. @entity1 whose @entity2490 began in the first year of life had more respiratory symptoms at age 6 and were more likely to have a diagnosis of @entity565 . Early introduction of foods or formula, heavy maternal cigarette smoking in the first year of life, and higher IgE, as well as @entity56 , were associated with early development of @entity2490 . Risk factors for PDAR that remained significant in a multivariate model included maternal history of physician-diagnosed @entity566 (odds ratio: 2.2, 95% confidence interval: 1.35-3.54), @entity565 in the @entity1 (4.06, 2.06-7.99), and IgE greater than 100 IU/mL at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were significantly higher only among those with high IgE and those who had @entity235 . CONCLUSION: @entity2023 developing in the first years of life is an early manifestation of an @entity18249 , which may be triggered by early environmental mental exposures.
