Chemotherapy-related XXXX in childhood @entity5 .

@entity1 @entity1665 @entity137 @entity5253 @entity5 @entity294 @entity391 @entity10701 @entity33 @entity699 @entity1583 @entity751 @entity99
PURPOSE: To evaluate the incidence and time of occurrence of chemotherapy-related toxic events in 100 @entity1 admitted to the Hematology-Oncology Ward of "Sfanta Maria" @entity1 's Emergency Hospital in Iasi, Romania, over a 4-year period. METHODS: An analytical, descriptive and comparative, retrospective and prospective study covering a 4-year period on the incidence of chemotherapy side effects, was performed on 100 @entity1 admitted for solid @entity5 or @entity1583 . The probability of each adverse event to appear and the time period from chemotherapy initiation to the moment of side effect appearance were assessed. RESULTS: The most frequent @entity137 was @entity1665 (79.5%), followed by medullary aplasia (71.1%), @entity5253 (65.3%), @entity294 and @entity391 (64% each), @entity99 (61%), and @entity699 (21.5%). @entity10701 and @entity5253 were less frequent (13.2% and 12.2%, respectively). Remissions of the underlying disease were achieved in 69.9% of the cases. Alopecia, medullary aplasia and @entity5253 developed during the first 14 months of treatment. @entity33 , @entity751 and @entity99 were diagnosed within the first 12 months of treatment. @entity294 or @entity5253 appeared during the first 15 months, while @entity699 developed during the first 6 months. All remissions were obtained during the first 4 months of treatment. CONCLUSIONS: While @entity1665 and medullary aplasia were the most frequent side effects of chemotherapy in our study group, the earliest were @entity699 , @entity751 and @entity99 .
