@entity7723 and the variability of hematological values in @entity1 with XXXX .

@entity1 @entity7723 @entity5427 @entity27127 @entity3458
Seventy @entity1 homozygous for Hb S (SS) and their 111 heterozygous ( @entity5427 ) parents were evaluated through their erythrocytic indices, hemoglobin composition, and occasionally through in vitro Hb chain synthesis values. Three groups of SS @entity1 and of @entity5427 parents were identified based on differences in degree of microcytosis (MCV) and (degree of hypochromia ( @entity27127 ) values. The level of Hb S in the Hb S heterozygotes showed a trimodal distribution. Five SS @entity1 had an @entity7723 homozygosity (alpha(0) alpha/alpha(0) alpha; beta(s)/beta(s) which was characterized by a distinct microcytosis and hypochromia (MCV), less than or equal to 70 fl; @entity27127 , less than or equal to 22 pp). Nine SS @entity1 had an @entity7723 heterozygosity (alpha(0)/alpha/alpha alpha; beta(s)/beta(s)) with an MCV value of 71 to 78 fl, and an @entity27127 value of 21.3 to 26.5 pg. Four @entity5427 parents had an @entity7723 homozygosity with values of MCV less than or equal to 71 fl and @entity27127 less than or equal to 23.5. The level of Hb S was less than 31%. Thirty-nine @entity5427 parents had an @entity7723 heterozygosity characterized by an MCV value of 72 to 79 fl, an @entity27127 value of 23.6 to 26.5, and a level of Hb S ranging between 31.0 and 36.8%. The Hb A2 level in SS @entity1 was significantly correlated with the RBC counts and the MCV and @entity27127 (r = 0.38, -0.52, and -0.47, respectively). Significant correlations in @entity5427 parents were also noted between the MCV, @entity27127 , RBC, and Hb S percentages (r = 0.62, 0.68, and -0.49, respectively). Although the data are limited, the simultaneous occurrence of an alpha-thal-2 homozygosity seems to decrease the level of Hb F in @entity3458 . The presence of an alpha-thal-2 heterozygosity or homozygosity together with an SS or @entity5427 condition resulted in identifiable hematologic phenotypes.
