Deficits in functional connectivity of hippocampal and frontal lobe circuits after XXXX .

@entity1 @entity1545 @entity131 @entity62 @entity130
OBJECTIVE: To examine the functional connectivity of hippocampal and selected frontal lobe circuits in @entity1 with @entity130 ( @entity130 ). DESIGN: Observational study. SETTING: An inpatient @entity131 unit. Imaging and neurocognitive assessments were conducted in an outpatient research facility. @entity1 : Twenty-five consecutive @entity1 with @entity1545 consistent with @entity130 and acute subcortical @entity62 were studied as well as 16 healthy volunteers of similar age and sex. INTERVENTIONS: Echo-planar and high-resolution T1-weighted images were acquired using 3-T scanners. Regions of interest (ROI) were drawn bilaterally for the hippocampus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex and were used to extract time series data. Blood oxygenation level-dependent data from each ROI were used as reference functions for correlating with all other brain voxels. Interhemispheric functional connectivity was assessed for each @entity1 by correlating homologous regions using a Pearson correlation coefficient. @entity1 functional and neurocognitive outcomes were assessed approximately 6 months after injury. MAIN OUTCOME MEASURES: Interhemispheric functional connectivity, spatial patterns of functional connectivity, and associations of connectivity measures with functional and neurocognitive outcomes. RESULTS: @entity1 showed significantly lower interhemispheric functional connectivity for the hippocampus and ACC. Controls demonstrated stronger and more focused functional connectivity for the hippocampi and ACC, and a more focused recruitment of the default mode network for the dorsolateral prefrontal cortex ROI. The interhemispheric functional connectivity for the hippocampus was correlated with delayed recall of verbal information. CONCLUSIONS: @entity130 may affect interhemispheric neural activity, as @entity1 with @entity130 show disrupted interhemispheric functional connectivity. More careful investigation of interhemispheric connectivity is warranted, as it demonstrated a modest association with outcome in chronic @entity131 .
