Plasma Levels of Interleukin-17, Interleukin-23, and Transforming Growth Factor-b in Sudanese XXXX with @entity1694 : A Case-Control Study.

@entity1 @entity1694 @entity4155 @entity2533 @entity272 @entity4452
BACKGROUND: @entity1694 is the most common @entity272 . It is a multifactorial polygenic disease with epidermal melanocyte destruction. The cytokines profile found in vitiliginous @entity1 was not fully elucidated. AIMS: We sought to assess the autoimmune nature of @entity1694 by comparing plasma levels of @entity4155 , @entity4452 , and @entity2533 ( @entity2533 ) in adult Sudanese @entity1694 @entity1 with matched control individuals. SUBJECTS AND METHODS: Case-control study was conducted in Khartoum Dermatologic Teaching Hospital, in the period between July and December 2013. The cases were 42 adult Sudanese @entity1694 @entity1 matched with 43 control individuals. The cytokines were measured in the plasma by the quantitative "sandwich" ELISA. RESULTS: @entity1 showed a significant lower median (25-75(th) inter-quartile) of @entity2533 than control (0.042 [0.041-0.044] vs. 0.047 [0.042-0.049]; P  <= 0.001). Both @entity4155 and @entity4452 showed no significant difference between cases and controls. @entity4155 showed a significant inverse relationship when correlated with @entity2533 (r = -0.24; P = 0.026) while showing direct relationship when correlated with age (r = 0.28; P = 0.009). CONCLUSION: The positive findings detected in this study coincide with the important immunoregulatory role of the @entity2533 , and support the autoimmune nature of the disease.
