Enhancement of colonic motor response to feeding by central endogenous opiates in the XXXX .

@entity235 @entity836 @entity12064 @entity5171
The role of endogenous opiates in the colonic motor response to feeding has been investigated in four @entity235 chronically fitted with two strain gages on the proximal and distal colon and a cannula in cerebral lateral ventricle. A daily meal stimulated the colonic motility during 8-10 hrs. The colonic motility index was significantly higher during this period when an enkephalinase inhibitor, @entity12064 , was intracerebroventricularly (i.c.v.) administered at a dose of 0.1 mg/kg before the meal. This effect was blocked by a previous i.c.v. administration of @entity836 (0.1 mg/kg) and reproduced by (D-Ala2, Met5) enkephalinamide ( @entity5171 ) at a dose of 50 mg/kg. I.c.v. administration of @entity12064 or @entity5171 did not modify the colonic motility in @entity235 fasted for 48 hrs. The postprandial motility index remained unchanged after intravenous administration of @entity12064 or @entity5171 at the same dosages. These results provide evidence for a central control of the colonic motor response to feeding by endogenous enkephalins in @entity235 .
