Evaluation of weight-adjusted doses of XXXX for prevention of @entity1209 in day care laparoscopic gynaecological surgery: A dose ranging, randomised controlled trial.

@entity1 @entity390 @entity7274 @entity1209
BACKGROUND: @entity7274 75mcg is being used for the prevention of @entity1209 . However, weight-adjusted doses in laparoscopic surgery are unevaluated. AIM: To determine the response to three doses of @entity7274 (0.5, 1.0, or 1.5mcgkg) over 72h in the postoperative period in @entity1 undergoing laparoscopic gynaecological procedures. DESIGN: A randomised dose-response study. SETTING: A tertiary care hospital and research institute in north India from July to December 2014. @entity1 : American society of Anesthesiologists physical status I and II @entity1 , from 18 to 60 years old, undergoing laparoscopic gynaecological procedures on a day care basis. METHODS: @entity1 were randomised to receive @entity7274 0.5, 1 and 1.5mcgkg intravenously before induction of anaesthesia. MAIN OUTCOMES MEASURES: The primary outcome was the proportion of @entity1 with a complete response (i.e. who neither vomited nor required additional antiemetic drugs for @entity390 during the first 72 postoperative hours). The proportion of @entity1 having @entity390 or emetic episodes and the requirement for rescue antiemetics and analgesics during the 72-h period were recorded as secondary outcomes. RESULTS: With @entity7274 , there was a significant dose-dependent increase (37.5 vs. 67.5 vs. 75%, P<0.001) in proportion of @entity1 with a complete response during the 72h. This was associated with a significant dose-dependent decrease in the proportion of @entity1 with @entity390 (77.5 vs. 47.5 vs. 35%, P<0.001) and vomiting (47.5 vs. 32.5 vs. 12.5%, P=0.003). CONCLUSION: Following laparoscopic gynaecological surgery, intravenous @entity7274 has a dose-dependent prophylactic effect against @entity1209 during the first 72 postoperative hours. TRIAL REGISTRATION: The trial was registered with Clinical trial registry of India(CTRI/2014/09/004987).
