Elimination of @entity1522 in XXXX .

@entity1 @entity1522 @entity2574 @entity2228 @entity3793 @entity5507 @entity2033 @entity1853 @entity177 @entity2340 @entity6778 @entity376 @entity367 @entity563 @entity1521 @entity815 @entity493 @entity369 @entity1889
Elimination of parenterally administered @entity1522 was investigated in @entity1 with @entity177 ( @entity177 ) (10 on conservative treatment = CT, 13 on regular hemodialysis therapy = @entity2033 ). In a bolus injection protocol 0.1 g @entity1522 as a 10% solution containing essential and nonessential @entity1522 were infused and pharmacokinetic parameters of 17 @entity1522 were calculated. The mean elimination half life was increased by 40% in CT and 87% in @entity2033 (p less than 0.001 CT and @entity2033 versus controls). Total clearance was reduced in CT (p less than 0.001 versus @entity2033 and controls). In CT clearance of @entity815 , @entity1521 , @entity493 , @entity3793 and @entity369 was reduced, of none of the @entity1522 elevated. In @entity2033 clearance of @entity1853 , @entity376 , @entity2574 and @entity563 was increased, of @entity1521 decreased. The total transfer rate was reduced in CT (p less than 0.025 versus controls) and transfer of @entity1889 , @entity2574 , @entity367 , @entity493 , @entity3793 and @entity369 was reduced in these @entity1 . Mainly due to elevated basal plasma concentration transfer of @entity1853 was elevated in CT and @entity2033 . In dialysis @entity1 transfer of @entity6778 , @entity2340 , @entity2228 and @entity563 was increased. Despite variations of absolute values of clearance between the two groups investigated relative clearance rates of @entity1522 were similar because of a uniform increase of clearance of about 37% in @entity2033 compared to CT (p less than 0.001). Results indicate that the elimination of parenterally administered @entity1522 is grossly altered in @entity5507 and that in @entity1 on CT and @entity2033 a uniform elimination pattern can be observed.
