Change of maternal thyroid function in XXXX .

@entity1 @entity1955 @entity1378 @entity3566 @entity14244 @entity1954
@entity1 chorionic gonadotropin ( @entity3566 ) has weak thyroid-stimulating activity because of its homology with thyroid stimulating hormone (TSH). In @entity14244 ( @entity14244 ), which is a severe complication of monochorionic twin pregnancies, a close association between maternal serum @entity3566 concentration and @entity14244 has been reported. And, @entity14244 can be treated by fetoscopic laser coagulation of the communicating vessels. To clarify the relationship between maternal serum @entity3566 and maternal thyroid function in @entity14244 , the present study investigated the change in thyroid hormone and @entity3566 levels after laser therapy. The protocol included collection of serial maternal blood samples in @entity14244 before laser therapy, and at two and four weeks after laser therapy. For 131 cases of @entity14244 , the following parameters were determined at each point: @entity3566 , TSH, free @entity1954 (fT3), and free @entity1955 (fT4). The multiple of the median (MoM) of pre-operative @entity3566 concentration in @entity14244 was 5.39 MoM (interquartile range, 2.83 - 8.64). There was a moderate positive correlation between @entity3566 and fT3 in @entity14244 pre-operatively (R = 0.22, P = 0.030). fT4 was also positively correlated with @entity3566 (R = 0.33, P < 0.001). Some cases showed very high concentration in fT3. When laser therapy for @entity14244 was effective, the @entity3566 concentration significantly decreased, and fT3 and fT4 decreased progressively in concert with the decrease in @entity3566 . The relationship between @entity3566 and thyroid function in @entity14244 supports the finding of @entity14244 as a novel etiology of @entity3566 -mediated @entity1378 during pregnancy.
