Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in @entity1 with Hodgkin's or XXXX ?

@entity1 @entity978 @entity706 @entity1893
INTRODUCTION: Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of @entity706 . We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in @entity1 with @entity978 ( @entity978 ) and aggressive @entity1893 (aNHL). METHODS: The medical files of a total of 297 @entity1 diagnosed with @entity978 or aNHL and followed at the hematology clinics of 3 major hospitals in   stanbul between 2008 and 2012 were screened retrospectively and 161 @entity1 with classical @entity978 and aNHL were included in the study. The @entity1 were referred for PET/CT and BMB at the initial staging. BMB was performed as the reference standard for the evaluation of BMI. RESULTS: There were 61 (38%) @entity978 and 100 (62%) aNHL @entity1 . Concordant results were revealed between PET/CT and BMB in 126 @entity1 (78%) (52 @entity978 , 74 aNHL), 20 with positive PET/CT and BMB results and 106 with negative PET/CT and BMB results. There were discordant results in 35 @entity1 (9 @entity978 , 26 aNHL), 16 of them with positive BMB and negative PET/ CT results and 19 of them with negative BMB and positive PET/CT results. DISCUSSION AND CONCLUSION: We observed that PET/CT is effective to detect BMI, despite it alone not being sufficient to evaluate BMI in @entity978 and aNHL. Bone marrow trephine biopsy and PET/CT should be considered as mutually complementary methods for detection of BMI in @entity1 with @entity706 . In suspected focal involvement, combining biopsy and PET/CT might improve staging results.
