Reduced rate of copy number aberrations in mucinous XXXX .

@entity1 @entity5 @entity189 @entity1017 @entity14 @entity393 @entity420
BACKGROUND: @entity189 ( @entity189 ) is found in 10%-15% of @entity14 ( @entity14 ) @entity1 . It differs from the common @entity420 ( @entity420 ) in histopathological appearance and clinical behavior. METHODS: Genome-wide DNA copy number and survival data from @entity189 and @entity420 primary @entity14 samples from @entity1 from two phase III trials (CAIRO and CAIRO2) was compared. Chromosomal copy number data from The @entity5 (TCGA) was used for validation. Altogether, 470 ACs were compared to 57 MCs. RESULTS: @entity189 showed a reduced amount of copy number aberrations (CNAs) compared with @entity420 for the CAIRO/CAIRO2 cohort, with a median amount of CNAs that was 1.5-fold lower (P = 0.002). Data from TCGA also showed a reduced amount of CNAs for @entity189 . @entity189 samples in both cohorts displayed @entity1017 at chromosome 20q and less @entity393 . A high rate of chromosomal instability was a strong negative prognostic marker for survival in @entity189 @entity1 from the CAIRO cohorts (hazard ratio 15.60, 95% CI 3.24-75.05). CONCLUSIONS: Results from this study indicate that the distinct @entity189 phenotype is accompanied by a different genetic basis when compared with @entity420 and show a strong association between the rate of chromosomal instability and survival in @entity189 @entity1 .
