Risk factors for XXXX and differential impact of liver transplantation on renal function.

@entity1 @entity644 @entity8 @entity5428 @entity2299 @entity648 @entity409 @entity740 @entity177 @entity412 @entity1011 @entity493
BACKGROUND: @entity740 ( @entity740 ) is a common problem in long-term survivors after liver transplantation (LT). It is important to identify and correct risk factors that negatively affect kidney function. The purpose of this study was to delineate the risk factors associated with progressive @entity8 after OLT. METHODS: We analyzed 50 recipients (10 female, 40 male) of overall age of 44  13 year who were all >= 18 years old and underwent first LT between 1999 and 2005. @entity1 -related risk factors were evaluated for @entity177 at 3 and 5 years after transplantation. We evaluated parameters of demographic data, laboratory values, daily @entity644 , and renal resistive index (RRI) by Doppler ultrasonography. @entity740 was defined as a sustained decrease in estimated glomerular filtration rate (eGFR). @entity1 were divided into 3 groups according to the change in eGFR from the baseline value: group 1, stable eGFR (no change from baseline); group 2, <50% decreased eGFR; and group 3, >= 50% decrease from baseline. eGFR was calculated by using @entity8 ( @entity8 ) formula. RESULTS: At 3 years after LT, GFR negatively correlated with initial @entity1 -Pugh score (r=-0.42; P<.01); microalbuminuria (r=-0.28; P<.01), and RRI (r=-0.36; P<.01). After 5 years, GFR negatively correlated with initial @entity5428 transferase (r=-0.21; P<.05), PT (r=-0.29; P<.05), and RRI (r=-0.32; P<.01). Pretransplantation direct @entity648 levels were significantly correlated with GFR decrease at 3 years (P=.05). At 5 years of follow-up, smoking (P<.05), baseline @entity493 aminotransferase (P=.03) and serum @entity412 (P<.01) levels significantly correlated with eGFR decrease. Pretransplantation serum @entity1011 levels were stratified into normal versus high groups. @entity1 with increased basal serum @entity1011 levels displayed shorter survivals than those with normal @entity1011 levels, namely, median values of 21  3.9 months versus 14  2.4 months, log rank test: P<.05). CONCLUSION: Renal function after liver transplantation show sustained impairment in certain @entity1 . In the short term the main risk factors for renal detoriation were severity of @entity409 before LT, microalbuminuria, and renal perfusion. In the long term, smoking and @entity2299 were the main predictors of @entity740 . @entity1 with high basal serum @entity1011 values were at increased risk of mortality.
