Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode XXXX and @entity716 .

@entity1 @entity353 @entity914 @entity1316 @entity161 @entity74 @entity716
CONTEXT: Whether @entity914 associated with @entity161 and @entity1316 represent manifestations of different @entity74 is an important but unresolved question in psychiatry. Results of previous volumetric magnetic resonance imaging investigations indicate that gray matter volume reductions in neocortical regions may be specific to @entity161 . OBJECTIVE: To simultaneously evaluate multiple olfactocentric paralimbic regions, which play crucial roles in @entity1 emotion and motivation, in first-episode @entity1 with @entity161 and @entity716 . DESIGN: A cross-sectional study using high-spatial resolution magnetic resonance imaging in @entity1 with @entity161 and @entity716 at their first hospitalization. SETTING: Inpatient units at a private psychiatric hospital. @entity1 : Fifty-three first-episode @entity1 , 27 with @entity161 and 26 with affective (mainly manic) @entity716 , and 29 control subjects. MAIN OUTCOME MEASURES: Using high-spatial resolution magnetic resonance imaging, the gray matter volumes of 2 olfactocentric paralimbic regions of interest, the insular cortex and the temporal pole, were evaluated. RESULTS: A bilateral @entity353 in insular cortex gray matter was specific to first-episode @entity1 with @entity161 . In contrast, both first-episode @entity716 groups showed a @entity353 in left temporal pole gray matter and an absence of normal left-greater-than-right asymmetry. Region of interest correlations showed that only @entity1 with @entity161 lacked a positive correlation between left temporal pole and left anterior amygdala-hippocampal complex gray matter volumes, whereas both @entity716 groups were similar in lacking normal positive correlations between left temporal pole and left anterior superior temporal gyrus gray matter volumes. CONCLUSIONS: These partially different and partially similar patterns of structural abnormalities in olfactocentric paralimbic regions and their associated abnormalities in other temporolimbic regions may be important factors in the differential and common manifestations of the 2 @entity914 .
