Bioassay of XXXX for possible carcinogenicity.

@entity706 @entity19 @entity5 @entity35 @entity157 @entity72284
A bioassay of @entity72284 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity72284 was administered in the feed, at either of two concentrations (except for female @entity35 ), to groups of 50 male and 50 female animals of each species. The time-weighted average dietary concentrations used in the chronic bioassay were 0.69 and 0.35 percent for high and low dose male @entity35 , respectively, 0.2 percent for the treated female @entity35 , and 1.0 and 0.5 percent, respectively, for high and low dose @entity19 of both sexes. After a 78-week period of chemical administration (80 weeks for high dose @entity19 ), observation of the @entity35 continued for up to an additional 32, weeks and observation of the @entity19 continued for up to an additional 16 weeks. In both species adequate numbers of animals in all groups, except the treated female @entity35 , survived sufficiently long to be at risk from late-developing @entity5 . The survival among treated female @entity35 was poor and, as a result, no conclusions could be made regarding the carcinogenicity of the compound in these animals. When male @entity35 having either @entity157 or neoplastic nodules of the liver were combined and the resulting @entity5 incidences were analyzed statistically, there was a significant positive association between dosage and the incidences of these combined @entity5 . @entity157 were observed at significantly higher incidences when dosed @entity19 were compared to controls. There was a significantly higher incidence of malignant @entity706 in high dose female @entity19 when compared to controls. Under the conditions of this bioassay, dietary administration of @entity72284 was carcinogenic in male Fischer 344 @entity35 , causing a @entity157 and neoplastic nodules of the liver. The compound was also carcinogenic in B6C3F1 @entity19 , causing @entity157 in both sexes and malignant @entity706 in females.
