A case of XXXX : simultaneous expression of several aberrant hormone receptors in the adrenal gland.

@entity1 @entity1831 @entity2661 @entity21087 @entity699 @entity29587 @entity701 @entity1176 @entity3044 @entity2419
@entity29587 ( @entity29587 ) is a rare cause of @entity699 . Recently, aberrant expression of adrenal receptors for various hormones and/or cytokines has been identified in several cases with @entity29587 , which may act as a pathogenetic factor for the disorder. We report here an @entity29587 @entity1 with a Rathke's @entity2419 . Endocrinological examinations revealed that the pituitary cyst had no hormonal secretion. Administrations of either AVP or @entity3044 provoked @entity701 production in the @entity1 , whereas DDAVP, @entity21087 or endogenous LH induced by @entity1176 did not. Reverse transcriptional-PCR analysis of total RNA obtained from the @entity1 's adrenal tissue revealed the expression of mRNA of receptors for V1a, V1b, V2, and LH/hCG. Three of these receptors except for V1a receptor were not expressed in normal adrenal tissue. Hyperosmolar saline infusion promoted the @entity1 's @entity701 secretion through the increase in endogenous AVP (peak plasma @entity1831 level reached 90.4 pg/ml during the test). These results suggest that endogenous AVP and @entity2661 are involved in the pathophysiology of the @entity1 . Further study will be necessary to clarify the molecular mechanisms that regulate tissue-specific expression of these receptors and their role in the overgrowth of adrenal in @entity29587 .
