The association between cardiovascular risk and cardiovascular magnetic resonance measures of @entity82 : the Multi-Ethnic Study of XXXX (MESA).

@entity1 @entity296 @entity82 @entity731 @entity2287 @entity65
BACKGROUND: Risk scores for @entity65 ( @entity65 ) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have T1 mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater @entity296 . METHODS: @entity65 risk scores for 1208 subjects ( @entity1 , 50.8%) ages 55-94 years old were evaluated in the Multiethnic Study of @entity731 (MESA) at six centers. T1 times were determined at 1.5Tesla before and after @entity2287 administration (0.15  mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native T1, 12 and 25  minute post- @entity2287 T1, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. @entity65 risk scores were significantly different for @entity1 and @entity1 (p   <   0.001). RESULTS: 25  minute post @entity2287 T1 time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native T1 (7/14 scores, 50%) and partition coefficient (7/14, 50%) in @entity1 . Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR @entity82 index. CONCLUSIONS: @entity1 with greater @entity65 risk had greater CMR indices of @entity296 . T1 times at greater delay time (25  minutes) showed better agreement with commonly used risk score indices compared to ECV and native T1 time. CLINICAL TRIAL REGISTRATION: http://www.mesa-nhlbi.org/, NCT00005487.
