Intraperitoneal application of XXXX plus @entity1286 for @entity158 relief after laparoscopic cholecystectomy.

@entity1 @entity10964 @entity1341 @entity1286 @entity158 @entity282
BACKGROUND AND OBJECTIVE: Intraperitoneal administration of a local anaesthetic in combination with an opioid, for the relief of @entity282 , has already been reported except after laparoscopic cholecystectomy. This study was aimed at assessing the analgesic effect of the intraperitoneal administration of @entity1341 and @entity1286 in @entity1 undergoing laparoscopic cholecystectomy. METHODS: At the end of laparoscopic cholecystectomy, in a double-blind, randomized manner, one of the following injections was given intraperitoneally. There were 30 @entity1 in each group: Group 1, physiological saline 30 mL; Group 2, @entity1341 0.25% 30 mL; Group 3, @entity1341 0.25% 30 mL plus @entity1286 2 mg. In addition, Group 2 received 2 mg intravenous (i.v.) @entity1286 in 2 mL saline, and Groups 1 and 3, 2 mL saline intravenously. @entity1 ' @entity282 was evaluated using a visual analogue scale and a verbal rating score. The postoperative analgesic requirement was assessed by the total dose of @entity10964 administered by an i.v. @entity1 -controlled analgesia (PCA) device. @entity158 , vital signs, supplemental analgesic consumption and side-effects were recorded for all @entity1 for 24 h. RESULTS: There were no differences between the three groups regarding @entity158 scores (at rest and coughing) during the study except in the first 2 h, when scores were lower for @entity1 receiving intraperitoneal @entity1341 plus i.v. @entity1286 (P < 0.05). Supplemental consumption of @entity10964 was significantly lower (P < 0.05) in Group 3 than in Group 1 during the first 6 h after surgery. However, the cumulative doses of @entity10964 were also lower in Group 2 than in Groups 1 and 3 over the entire study (2025 +/- 1044 mg vs. 4925 +/- 1238 and 4125 +/- 1276mg; P < 0.05). CONCLUSIONS: In @entity1 undergoing laparoscopic cholecystectomy, the intraperitoneal administration of @entity1286 plus @entity1341 0.25% reduced the analgesic requirements during the first 6 postoperative hours compared with the control group. However, the combination of intraperitoneal @entity1341 0.25% and i.v. @entity1286 was more effective for treatment of @entity158 after laparoscopic cholecystectomy.
