Three XXXX Polymorphisms and Cancer Risk: A Meta-Analysis of Case-Control Studies.

@entity6344 @entity15443 @entity5 @entity43645 @entity6993 @entity70706 @entity14 @entity13284 @entity70705
BACKGROUND: Studies have come to conflicting conclusions about whether polymorphisms in the @entity15443 gene ( @entity15443 ) are associated with @entity5 risk. To help resolve this question, we meta-analyzed case-control studies in the literature. METHODS: PubMed, EMBASE, Cochrane Library, the Chinese Biological Medical Database and the Chinese National Knowledge Infrastructure Database were systematically searched to identify all case-control studies published through February 2015 examining any @entity15443 polymorphisms and risk of any type of @entity5 . Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. RESULTS: A total of 13 case-control studies involving 5,750 cases and 6,762 controls were analyzed. Analysis of the entire study population revealed a significant association between @entity70705 ( @entity13284 ) and overall @entity5 risk using a homozygous model (OR 0.82, 95%CI 0.72 to 0.94), heterozygous model (OR 0.84, 95%CI 0.76 to 0.93), dominant model (OR 0.85, 95%CI 0.75 to 0.97) and allele contrast model (OR 0.88, 95%CI 0.80 to 0.97). However, subgroup analysis showed that this association was significant only for Asians in the case of @entity14 . No significant associations were found between @entity70706 ( @entity6344 ) or @entity43645 ( @entity6993 ) and @entity5 risk, either in analyses of the entire study population or in analyses of subgroups. CONCLUSIONS: Our meta-analysis suggests that the @entity15443 @entity70705 ( @entity13284 ) polymorphism, but not @entity70706 ( @entity6344 ) or @entity43645 ( @entity6993 ), may be associated with @entity5 risk, especially risk of @entity14 in Asians. Large, well-designed studies are needed to verify our findings.
