CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in @entity356 XXXX .

@entity1 @entity12711 @entity5 @entity12710 @entity3 @entity356
BACKGROUND: Impaired or reduced @entity12711 ( @entity12711 ) expression in T cells has been identified in various @entity5 and may be associated with an ineffective immune response. The clinical significance of @entity12711 chain expression in @entity5 -infiltrating lymphocytes (TILs) in @entity356 remains unclear. METHODS: The authors immunohistochemically investigated @entity12711 expression in TILs in 185 @entity1 who had undergone curative gastrectomy. @entity12710 ( @entity12710 ) ratios were calculated. @entity1 were divided into two groups: a normal @entity12711 group (n = 121) and a reduced @entity12711 group (n = 64). @entity1 with a zeta per epsilon ratio of greater than 66% were placed in the normal @entity12711 group. RESULTS: @entity1 in the normal @entity12711 group had fewer lymph node @entity3 (P < 0.01) and a shallower depth of invasion (P < 0.05) than those in the reduced @entity12711 group. The 5-year survival rate was 72% in the normal @entity12711 group, which was significantly better than that in the reduced @entity12711 group (55%; P < 0.01). When stratified according to clinical stage, the prognostic value was significantly different only in Stage IV @entity1 . Multivariate analysis showed that @entity12711 expression was an independent prognostic factor (P = 0.03) next to depth of invasion and lymph node involvement. CONCLUSIONS: Reduced @entity12711 expression in TILs was strongly correlated with @entity356 . @entity12711 expression in TILs is considered an immunologic, independent prognostic marker in @entity356 @entity1 . @entity12711 normalization with cytokine treatment may lead to prolonged survival in advanced @entity356 @entity1 .
