Effects on cognitive and clinical insight with the use of Guided Self-Determination in outpatients with XXXX : A randomized open trial.

@entity1 @entity161 @entity5624 @entity6
UNASSIGNED: Poor insight has a negative impact on the outcome in @entity161 ; consequently, poor insight is a logical target for treatment. However, neither medication nor psychosocial interventions have been demonstrated to improve poor insight. A method originally designed for @entity6 @entity1 to improve their illness management, Guided Self-Determination (GSD), has been adapted for use in @entity1 with @entity161 (GSD-SZ). The purpose of this study was to investigate the effect on insight of GSD-SZ as a supplement to treatment as usual ( @entity5624 ) as compared to @entity5624 alone in outpatients diagnosed with @entity161 . The design was an open randomized trial. The primary hypothesis was cognitive insight would improve in those @entity1 who received GSD-SZ+ @entity5624 as assessed by the BCIS. We additionally explored whether the intervention led to changes in clinical insight, self-perceived recovery, self-esteem, social functioning and symptom severity. Assessments were conducted at baseline, and at 3-, 6- and 12-month follow-up. Analysis was based on the principles of intention to treat and potential confounders were taken into account through applying a multivariate approach. A total of 101 @entity1 were randomized to GSD-SZ+ @entity5624 (n=50) or to @entity5624 alone (n=51). No statistically significant differences were found on the cognitive insight. However, at 12-month follow-up, clinical insight (measured by G12 from the Positive and Negative Syndrome Scale), symptom severity, and social functioning had statistically significantly improved in the intervention group as compared to the control group. "Improving insight in @entity1 diagnosed with @entity161 ", NCT01282307, http://clinicaltrials.gov/.
