Trends in timing of prenatal diagnosis and abortion for fetal XXXX .

@entity1 @entity5852 @entity1467 @entity2008 @entity7440
OBJECTIVE: Our objective was to evaluate changes in the timing of prenatal diagnosis and abortion for @entity2008 over the past 10 years. STUDY DESIGN: This retrospective review identified singleton pregnancies with fetal @entity2008 that were diagnosed from 2005-2014 and included @entity1467 , @entity7440 . The study period was divided into 3 intervals: 2005-2006; 2007-2011; and 2012-2014. Gestational ages at prenatal diagnosis and abortion were compared over these intervals. RESULTS: The 213 cases included 142 cases of @entity1467 (66.7%), 47 cases of Trisomy 18 (22.1%), and 24 cases of Trisomy 13  (11.3%). Two hundred one @entity1 (94.4%) chose to undergo abortion. The median gestational ages at prenatal diagnosis and @entity5852 or 13 were 12 weeks (interquartile range, 12-13 weeks) and 13 weeks (interquartile range, 12-15.5 weeks) and did not change over the study period. In contrast, in pregnancies with @entity1467 , the median gestational age at prenatal diagnosis (16, 13, and 12 weeks; P < .001) and abortion (17, 14, and 13 weeks; P  <  .001) both decreased significantly over the study intervals. In @entity1467 pregnancies, the proportion of @entity1 who underwent chorionic villus sampling significantly increased over the 3 study intervals (36%, 63%, and 86%; P < .001). CONCLUSION: Since 2005, the gestational ages at prenatal diagnosis and abortion for @entity1467 have declined significantly. These changes are likely attributable to improvements in early screening that leads to higher rates of chorionic villus sampling.
