Intensity modulated radiation therapy for XXXX of the extremity: preliminary results.

@entity1 @entity174 @entity242 @entity5 @entity4 @entity16 @entity20787 @entity2693
PURPOSE: To report preliminary results on using intensity modulated radiation therapy (IMRT) as an adjuvant treatment in @entity242 (STS) of the extremity. METHODS AND MATERIALS: Between February 2002 and March 2005, 31 adult @entity1 with primary STS of the extremity were treated with surgery and adjuvant IMRT. @entity5 size was >10 cm in 74% of @entity1 and grade was high in 77%. Preoperative IMRT was given to 7 @entity1 (50 Gy) and postoperative IMRT (median dose, 63 Gy) was given to 24 @entity1 . Complete gross resection including periosteal stripping or bone resection was required in 10, and neurolysis or nerve resection in 20. The margins were positive or within 1 mm in 17. Complications from surgery and radiation therapy (RT) were assessed using the Common Terminology Criteria for Adverse Events grading system. RESULTS: Median follow-up time was 23 months. Grade 1 @entity20787 developed in 71% of @entity1 , Grade 2 in 16%, and Grade 3 in 10%. Infectious wound complications developed in 13% and noninfectious complications in 10%. Two @entity1 (6.4%) developed @entity174 . Grade 1 @entity16 developed in 28% of @entity1 and Grade 2 in 5%. The rates of Grade 1 and 2 joint @entity2693 were each 19%. Grade 1 @entity4 was observed in 19% of @entity1 and Grade 2 in 13%. The 2-year local control, distant control, and overall survival were 95%, 65%, and 81%, respectively. CONCLUSION: Intensity modulated RT appears to provide excellent local control in a difficult group of high-risk @entity1 . The morbidity profile is also favorable, but longer follow-up is needed to confirm the results from this study.
