Neuroendocrine regulation and central dopamine (DA) systems in physical and XXXX .

@entity4545 @entity1642
Physical and @entity1642 cause different patterns of changes in the fluorescence intensity of nigral and tuberoinfundibular DA neurons which point to changes in neuronal activity. In order to investigate possible interactions between @entity4545 (alpha-melanotropin) and DA systems in stress, systemic and intraventricular injections of antiserum against @entity4545 were made. The functional state of DA neurons was assessed by histochemical microfluorimetry and hormone levels were measured by radioimmunossay. Antiserum against @entity4545 was found to affect the functional state of DA neurons, but only thorugh the intravenous route. Under physical stress i.v. injection of antiserum against @entity4545 was accompanied by elevated levels of activity of the DA neurons of the substantia nigra. An intraventricular injection of the same antiserum was ineffective. In @entity1642 , an effect was again seen only after intravenous injection of antiserum against @entity4545 . In this situation, the activity in DA cell groups of the substantia nigra, ventral tegmental area and tubero-infundibular system was increased after antiserum injection. Possible influences from manipulations were checked; certain effects which depended upon experimental situation were noted. Our data suggest a modulatory influence of circulating @entity4545 on the functional state of central DA systems.
