Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of XXXX .

@entity5 @entity2085
OBJECTIVES: This review is to explore whether potential gene interactions in the cell cycles of gametes, zygotes, and @entity2085 ( @entity2085 ) cells are associated with the development of @entity5 . METHODS: MEDPILOT at the Central Library of the University of Cologne, Germany (Zentralbibliothek K  ln) that covers 5,800 international medical journals and 4,300 E-journals was used to collect data. The initial searches were done in December 2012 and additional searches in October 2013-May 2015. The search terms included " @entity5 development," "gene interaction," and " @entity2085 cells," and the time period was between 1998 and 2015. A total of 147 articles in English language only were included in this review. RESULTS: Transgenerational gene translation is implemented in the zygote through interactions of epigenetic isoforms of transcription factors (TFs) from parental gametes, predominantly during the first two zygote cleavages. Pluripotent transcription factors may provide interacting links with mutated genes during zygote-to- @entity2085 cell switches. Translation of post-transcriptional carcinogenic genes is implemented by abnormally spliced, @entity5 -specific isoforms of gene-encoded mRNA/non-coding RNA variants of TFs employing de novo gene synthesis and neofunctionalization. Post-translationally, mutated genes are preserved in pre-neoplastic @entity2085 cell subpopulations that can give rise to overt @entity5 stem cells. Thus, TFs operate as cell/disease-specific epigenetic messengers triggering clinical expression of @entity5 . CONCLUSION: Potential gene interactions in the cell cycle of gametes, zygotes, and @entity2085 cells may play some roles in the development of @entity5 .
