Influence of dietary factors on XXXX survival.

@entity1 @entity5 @entity1735 @entity14 @entity204
BACKGROUND: Diet has been identified as a major determinant of @entity14 ( @entity14 ) but little is known of its influence on @entity14 survival. AIMS: To study the influence of dietary factors on survival in @entity1 who had undergone potentially curative @entity14 surgery. @entity1 : Among 171 @entity1 included in a case control study of @entity14 aetiological factors, 10 year survival data on 148 @entity1 who underwent resection of the @entity5 for potential cure were obtained from a Registry of Digestive Tumours. METHODS: Tertiles of food and nutrient intakes were entered into Cox proportional hazards survival models, controlling for age, sex, @entity5 stage, and @entity5 location. RESULTS: Only five year survival was influenced by the pre-diagnosis diet. High energy intake, as a result of high @entity1735 , protein, and lipid intake, was strongly related to increased survival. Five year relative risk of @entity204 for the highest versus the two lowest tertiles of energy intake was 0.18 (95% confidence interval 0.07; 0.44). This effect was similar in both sexes, for the colon and for the rectum. It was stronger in @entity1 with N+/M+ @entity5 (relative risk 0.06) than in those with less advanced @entity5 (relative risk 0.37; stage-energy interaction term non-significant). No specific food or nutrient could be identified as having prognostic significance. CONCLUSIONS: Whether high energy intake selects less severe tumoral clones or modifies antitumoral immunity remains unclear. Larger series need to be investigated before conducting intervention studies but our findings should prompt nutritional follow up in @entity14 @entity1 .
