The gut microbiome as a target for regulatory T cell-based immunotherapy: induction of regulatory lymphocytes by oral administration of anti- XXXX enriched colostrum alleviates immune mediated @entity1960 .

@entity32 @entity558 @entity19 @entity1618 @entity1959 @entity3783 @entity1960 @entity1961 @entity8787 @entity3744 @entity10776 @entity291 @entity526
BACKGROUND: Gut-derived bacterial endotoxin is an important cofactor in the pathogenesis of @entity8787 . Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance and can prevent and alleviate @entity8787 . To determine the immune modulatory effect of anti- @entity558 enriched hyperimmune colostrum, its ability to induce Tregs and alleviate immune mediated @entity1960 . METHODS: Immune-mediated @entity1960 was induced in @entity19 by intra-colonic instillation of @entity1959 ( @entity10776 ). Four groups of @entity19 were orally administered with two dosages of IgG-enriched colostrum fractions. The fractions were harvested from @entity291 immunized against @entity558 derived from intestinal @entity526 bacteria (Imm124E). Control @entity19 received non-immunized colostrum or vehicle (PBS). Treatment was administered one day following sensitization and four additional days following the administration of @entity10776 . The following parameters in the @entity19 were tracked: body weight, bowel histology, serum cytokine levels and regulatory T cells. RESULTS: Oral administration of Imm124E hyperimmune colostrum ameliorated immune-mediated @entity1960 . Significant amelioration of weight reduction was noted in treated @entity19 . Oral administration of Imm124E improved bowel histology. Both the extent of the disease, @entity32 score, and @entity1960 damage and regeneration scores decreased in Imm-124E treated animals. These effects were associated with an increase in serum @entity1618 anti inflammatory cytokine levels, and an increase in @entity1961   +   @entity3783 + and @entity1961   +   @entity3744 + Tregs. CONCLUSIONS: Oral administration of Imm124E promoted Tregs and @entity32 in immune mediated @entity1960 . The present data suggests that the microbiome may serve as a target for Tregs-based immunotherapy.
