Intracellular signaling in @entity6824 -induced microglia activation: role of XXXX .

@entity75 @entity4222 @entity584 @entity11654 @entity460 @entity6824 @entity669
Microglia are reactively activated by various environmental stimulations caused by @entity75 . Activated microglia exhibit morphological transformation, proliferation, @entity4222 , phagocytosis, and the production of bioactive molecules. Various molecules are reported and suggested to activate microglia. Among them, @entity6824 ( @entity6824 ) is considered one of the most convincing candidates responsible for maintaining activation properties of microglia. Therefore, the focus of the present study is on intracellular molecular events that arise downstream of @entity6824 stimulation. @entity6824 activates its receptor, Fms @entity669 kinase, and Fms sequentially activates a number of signaling molecules, including PI3K or phospholipase Cgamma (PLCgamma). Stimulation of continuing signaling cascades results in the activation of a small GTPase, @entity584 , the key molecule in microglia activation. @entity584 is known to be activated downstream of receptor @entity669 kinases and to regulate reorganization of the actin cytoskeleton, which profoundly underlies the above-mentioned properties of activated microglia. @entity11654 , a macrophage/microglia-specific @entity460 -binding protein, was identified by our group and was shown to be involved in the @entity584 signaling pathway. Further, we introduce a novel signaling pathway in which @entity584 is activated, dependent on PLCgamma and @entity11654 . However, to understand the molecular details of microglia activation, future work is required.
