Assessing cutoff values for XXXX to predict incident @entity101 in a general population.

@entity1 @entity101 @entity13519 @entity2708
OBJECTIVE: Cutoff values for @entity101 (BP) are not established in @entity101 guidelines. The aim of the study was to assess optimal cutoff values for increased exercise BP to predict incident @entity101 . METHODS: Data of 661 normotensive @entity1 (386 @entity1 ) aged 25-77 years from the Study of Health in Pomerania ( @entity2708 ) with a 5-year follow-up were used. Exercise BP was measured at a submaximal level of 100W and at maximum level of a symptom-limited cycle ergometry test. Cutoff values for increased exercise BP were defined at the maximum sum of sensitivity and specificity for the prediction of incident @entity101 . The area under the receiver-operating characteristic curve (AUC) and net reclassification index (NRI) were calculated to investigate whether increased exercise BP adds predictive value for incident @entity101 beyond established cardiovascular risk factors. RESULTS: In @entity1 , values of 160mmHg (100W level; AUC=0.7837; NRI=0.534, P<0.001) and 210mmHg (maximum level; AUC=0.7677; NRI=0.340, P=0.003) were detected as optimal cutoff values for the definition of increased exercise @entity13519 . A value of 190mmHg (AUC=0.8347; NRI=0.519, P<0.001) showed relevance for the definition of increased exercise @entity13519 in @entity1 at the maximum level. CONCLUSION: According to our analyses, 190 and 210mmHg are clinically relevant cutoff values for increased exercise @entity13519 at the maximum exercise level of cycle ergometry test for @entity1 and @entity1 , respectively. In addition, for @entity1 , our analyses provided a cutoff value of 160mmHg for increased exercise @entity13519 at the 100W level.
