Allergies and Disease Severity in XXXX : Preliminary Findings.

@entity1 @entity483 @entity2725 @entity2023 @entity565 @entity2490 @entity2724 @entity56 @entity25
INTRODUCTION: @entity2724 frequently begins in childhood, and is characterized by excessive @entity25 , with the presence of @entity2725 reflecting a more severe phenotype. @entity2724 may result from genetic predisposition involving deregulation of immune pathways, particularly involving T helper 2 cells (Th2). Increased activation of Th2 cells is usually manifested as @entity56 such as @entity2490 , @entity483 , and @entity565 . We hypothesized that the presence of @entity56 indicative of increased Th2 balance may dampen the severity of the phenotype in @entity1 with @entity2724 . METHODS: A retrospective chart review of childhood @entity2724 @entity1 was conducted at three major pediatric sleep centers. @entity1 were divided into those with @entity2724 without @entity2725 (NC-) and @entity2724 with @entity2725 (NC+). Demographics, polysomnographic and Multiple Sleep Latency Test data, and extraction of information on the presence of @entity56 such @entity2023 , @entity483 , and @entity565 was performed. RESULTS: There were 468 @entity1 identified, with 193 @entity1 in NC- group and 275 @entity1 in the NC+ group. Overall, NC+ @entity1 were significantly younger, had higher body mass index, and had shorter mean sleep latencies and increased sleep onset rapid eye movement events. The frequency of @entity56 , particularly @entity565 and @entity2023 , was markedly lower in NC+ (58/275) compared to NC- @entity1 (94/193; P < 0.0001). CONCLUSION: Involvement of the immune system plays an important role in the pathophysiology of @entity2724 . Current findings further suggest that an increased shift toward Th2, as indicated by the presence of @entity56 , may modulate the severity of the phenotype in childhood @entity2724 , and reduce the prevalence of @entity2725 in these @entity1 .
