Correlates of XXXX resistance in older individuals with and without kidney disease.

@entity650 @entity6 @entity1674 @entity2690 @entity740 @entity1254
BACKGROUND: @entity740 ( @entity740 ) is associated with @entity2690 resistance (IR). Prior studies have found that in individuals with @entity740 , leptin is associated with fat mass but resistin is not and the associations with @entity1254 are conflicting. This suggests that the mechanism and factors associated with IR in @entity740 may differ. METHODS: Of the 2418 individuals without reported @entity6 at baseline, participating in the Health, Aging and Body Composition study, a study in older individuals aged 70-79 years, 15.6% had @entity740 defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) based on cystatin C. IR was defined as the upper quartile of the homeostasis model assessment. The association of visceral and subcutaneous abdominal fat, percent body fat, muscle fat, lipids, inflammatory markers and @entity1254 were tested with logistic regression. Interactions were checked to assess whether the factors associated with IR were different in those with and without @entity740 . RESULTS: Individuals with IR had a lower eGFR (80.7    20.9 versus 75.6    19.6, P < 0.001). After multivariable adjustment, eGFR (odds ratio per 10 mL/min/1.73 m(2) 0.92, 95% confidence interval 0.87-0.98) and @entity740 (1.41, 1.04-1.92) remained independently associated with IR. In individuals with and without @entity740 , the significant predictors of IR were male sex, black race, higher visceral fat, abdominal subcutaneous fat and @entity1674 . In individuals without @entity740 , IR was associated with lower high-density lipoprotein and current nonsmoking status in multivariate analysis. In contrast, among individuals with @entity740 , @entity650 ( @entity650 ) was independently associated with IR. There was a significant interaction of eGFR with race and @entity650 with a trend for adionectin but no significant interactions with @entity740 (P > 0.1). In the fully adjusted model, there was a trend for an interaction with @entity1254 for eGFR (P = 0.08) and significant for @entity740 (P = 0.04 ), where @entity1254 was associated with IR in those without @entity740 but not in those with @entity740 . CONCLUSIONS: In mainly Stage 3 @entity740 , kidney function is associated with IR; except for @entity1254 , the correlates of IR are similar in those with and without @entity740 .
