Choice of anesthetic alters the circulatory shock pattern as gauged by conscious XXXX endotoxemia.

@entity4485 @entity26 @entity3652 @entity35 @entity5161 @entity4488
A standardized @entity35 endotoxin shock model was used to assess the differential effects of four commonly used anesthetics upon hemodynamics before and during endotoxin shock. Forty-nine male @entity35 weighing 307 +/- 4 g were divided into five groups:freely-moving conscious, @entity4488 (2%), @entity5161 (1.4%), @entity4485 (6 mg.kg-1.h-1 i.v.), and @entity3652 (45 mg.kg-1.h-1 i.v.). Anesthetic doses were chosen as 1.0 MAC equivalent. Anesthetized @entity35 were intubated and ventilated with @entity26 . The right carotid artery was cannulated with a thermocouple-catheter for aortic blood pressure, heart rate, and thermodilution cardiac output measurements. The right jugular vein was cannulated for measurement of central venous pressure and for i.v. injections. Data were collected over a 30-min baseline period and for 4 h after an i.v. bolus of endotoxin (40 mg.kg-1, LD100 within 24 h). Gross small intestinal pathology was rated on a 0-4 scale. Anesthetic effects were judged in terms of significant deviations from the awake data on each parameter. Despite differing patterns, total deviations were similar for @entity4488 , @entity3652 , and @entity4485 , although the latter drug was the least preferable due to particularly high systemic vascular resistance. Significantly less hemorrhagic small intestinal pathology occurred with @entity4488 . @entity3652 offered no advantage over the inhalation anesthetics. Among the four anesthetics tested, results were closest to the awake pattern with @entity5161 anesthesia, thus making it the logical choice for hemodynamic studies in experimental shock research.
