T cell receptor gene therapy for XXXX .

@entity1310 @entity625 @entity19 @entity17796 @entity1753 @entity79 @entity3744 @entity792
The current quality of @entity792 treatments is not satisfactory in regard to efficacy and safety. Antigen-specific immunotherapy is a future therapy that could achieve maximal efficacy with minimal adverse effects. T cells are essential components in antigen-specific immunity. However, we do not have a sufficient strategy for manipulating antigen-specific T cells. We propose that T cell receptor (TCR) gene transfer is a hopeful approach for antigen-specific immunotherapy. We confirmed the efficacy of TCR gene therapy in animal models of @entity792 and @entity625 . In lupus-prone NZB/W F1 @entity19 , nucleosome-specific TCR and @entity17796 Ig transduced cells suppressed autoantibody production and @entity1310 development. In the therapeutic experiment of @entity1753 ( @entity1753 ), @entity625 -related TCRs were isolated from single T cells accumulating in the @entity625 site. @entity625 -related TCR and TNFRIg transduced cells or TCR and @entity3744 transduced cells suppressed @entity625 progression and @entity79 . Therefore, engineered antigen-specific cells manipulated to express appropriate functional genes could be applied to specific immunotherapy.
