Evaluation of periodontitis in hospital outpatients with XXXX . A focus on gingival and circulating cytokines.

@entity1 @entity650 @entity558 @entity308 @entity66 @entity2520 @entity1356
UNASSIGNED: An imbalance in stimulated cytokine production is associated with the etiopathogenesis of @entity66 such as @entity308 ( @entity308 ) and @entity2520 . Increased cytokine levels have been reported in the gingival crevicular fluid (GCF) of @entity1 with @entity308 . Thirty-six outpatients with @entity308 participated in this study. Each outpatient was age-matched (  3years) with a healthy control (n=36). The @entity1 were controlled for race and smoking habits. Unstimulated and stimulated @entity650 ( @entity650 ), @entity1356 ( @entity1356 ), and interferon-y (INF-y) production in whole blood culture (WBC) and @entity650 and @entity1356 levels in the GCF were evaluated. Circulating levels of @entity650 and @entity1356 (unstimulated) as well as GCF @entity1356 were modestly lower in @entity308 @entity1 , compared to the levels in age-matched controls (Mann-Whitney, p=0.002, 0.0075, ANCOVA, p=0.025, respectively). In the unstimulated group, there was no correlation between the levels of circulating @entity650 and GCF @entity650 (r=0.07, p=0.67), and between the levels of circulating @entity1356 and the @entity1356 level in the CGF (r=-0.08, p=0.63). In the @entity558 stimulation group, there was no correlation between the levels of circulating levels of @entity650 and GCF @entity650 (r=0. 02, p=0.91) or between the circulating @entity1356 and GCF @entity1356 (r=0.13, p=0.42). We observed modest immunosuppression in @entity308 @entity1 (evaluated by no stimulation whole blood culture [WBC]), especially in @entity1 with @entity308 , @entity308 , and severe @entity308 .
