Major histocompatibility antigens and antigen-processing molecules in XXXX .

@entity8459 @entity1531 @entity5 @entity2262 @entity10553 @entity2184 @entity3 @entity320
PURPOSE: Malignant transformation of cells is frequently associated with abnormalities in the human leukocyte antigen (HLA) expression. These abnormalities may play a role in the clinical course of the disease, because HLA antigens mediate interactions of @entity5 cells with T cells and natural killer cells. @entity2184 is a highly @entity5 and is characterized by hematogenic spread to liver. Antigen-processing molecules (APMs) are necessary for efficient expression of HLA class I antigens. We studied the expression of HLA antigens and the APM in @entity2184 by immunohistochemistry and correlated clinicopathologically. EXPERIMENTAL DESIGN: @entity1531 , @entity2262 ( @entity2262 ), HLA class II antigens, and the APM comprising proteasomal subunits low molecular mass polypeptide ( @entity10553 , beta-subunit of LMP2-Delta, @entity8459 , transporter associated protein 1 subunit, and chaperone molecules tapasin and calnexin were studied in 41 primary @entity2184 archival specimens by immunohistochemistry. Immunoanalysis was done by a semiquantitative method and correlated with extrascleral extension, cell types, and the @entity5 diameter. RESULTS: @entity1531 , @entity2262 , HLA class II antigen, and the APM were decreased (negative staining in 29 @entity5 and dull staining in 3 @entity5 ) in 100% (32 of 32) @entity2184 with no extrascleral extension. (P = 0.01) and positive (bright staining) in 67% (4 of 9) @entity5 with liver @entity3 . Decreased immunoexpression of HLA antigens and the APM was seen in nonepithelioid cell @entity320 . There was no correlation with @entity5 diameter. CONCLUSIONS: Our data suggest decreased expression of HLA, and APM are seen in @entity2184 with no extrascleral extension and in nonepithelioid cell @entity320 . Decreased expression of APM may contribute to decreased @entity1531 expression.
