Long-term effects of myotomy and partial fundoplication for XXXX .

@entity1318 @entity1 @entity16 @entity1282
Controversy persists in the surgical approach to treat @entity1318 . This investigation reports the long-term effects of esophageal myotomy and partial fundoplication in treating this disorder. From 1984 to 1998, 32 @entity1 with @entity1318 underwent myotomy and partial fundoplication (Belsey Mark IV) using a left thoracotomy. The median follow up is 7.2 years. Assessments include clinical evaluation, esophagogram, radionuclide transit, manometry, 24-h pH, and endoscopy. There is no complication and no mortality. Preoperative assessment was compared with that in 0-3, 3-7, and 7-16 postoperative years. Clinically, the prevalence of @entity1282 was decreased from 100% to 6%, 12%, and 13%, respectively (P < 0.001). Heartburn remains unchanged (P > 0.25). On radiology, the prevalence of barium stasis was decreased from 97% to 44%, 48%, and 47%, respectively (P=0.001), whereas a pseudo-diverticulum was observed in two-thirds of @entity1 after operation (P=0.001). Percent radionuclide stasis at 2 min was measured as 70%, 17%, 20%, and 20%, respectively (P=0.001). Manometrically, lower esophageal sphincter (LES) gradient was decreased from 29 to 10, 9, and 9 mmHg, respectively (P=0.001). LES relaxation was improved from 41% preoperatively to 100% postoperatively at each postoperative period (P < 0.001). An abnormal acid exposure was observed in four @entity1 after the operation. Endoscopy documented @entity16 in three @entity1 (P > 0.25). In conclusion, on long-term follow up, myotomy and partial fundoplication for @entity1318 relieve obstructive symptoms and improve esophageal emptying, and reduce LES gradient and improve LES relaxation. Acid reflux is recorded in 13% of @entity1 and esophageal @entity16 is identified in 11% of the @entity1 population. A longer myotomy not covered by the fundoplication results in pseudodiverticulum formation and increased esophageal retention.
