Optical coherence tomography accurately identifies XXXX with penile (pre) malignant lesions: A single center prospective study.

@entity1 @entity536 @entity546 @entity121
INTRODUCTION: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which @entity536 ( oct) can be quantified. We hypothesize that qualitative (image assessment) and quantitative ( @entity536 ,  oct) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. MATERIALS AND METHODS: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive @entity1 with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer @entity121 and  oct. Results were grouped according to histopathology reports. RESULTS: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that @entity536 was significantly different between benign and (pre) malignant tissue, respectively, P = 0.001 and P < 0.001. CONCLUSION: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious @entity546 shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.
