Different determinants of neovascularization on the optic disc and on the retina in XXXX with severe nonproliferative @entity6 .

@entity1 @entity2175 @entity227 @entity8 @entity6 @entity854 @entity989
Almost all @entity1 with type I and many with @entity2175 develop @entity989 . This entity consists of two components: new blood vessels on the optic disc (NVD), which frequently lead to @entity227 , and new blood vessels elsewhere on the retina (NVE), which do not pose such a serious threat to vision. This study examined determinants of neovascularization specifically on the optic disc in eyes with @entity989 . The study eyes were under surveillance as the untreated control eyes of @entity1 in the @entity6 Study. During the 5-year follow-up period, NVE developed in almost all of the eyes, whereas the cumulative incidence of NVD in these same eyes was 64% and varied according to several factors. The risk of NVD in a study eye was increased if the contralateral treated eye had NVD rather than NVE or @entity989 (odds ratio [OR], 6.1; P < .0001). It was also increased if the study eye had, at the baseline examination, soft exudates and @entity854 (OR, 5.7; P = .002) or soft exudates alone (OR, 4.0; P = .04). @entity8 and poor glycemic control were each associated with a two-fold increase in risk but neither was statistically significant. Eyes of individuals over 40 years of age were protected from the development of NVD (OR, 0.5; P < .05). The findings of this study support the hypothesis that, in @entity1 with @entity6 , the development of NVD is determined by different factors than the development of NVE.
