Stability of XXXX in intravenous solutions.

@entity4388 @entity2634 @entity4337 @entity7368 @entity2827 @entity413
The stability of @entity7368 in a variety of i.v. solutions was studied. Solutions of @entity7368 10 mg/mL were prepared separately in 0.45% @entity2827 injection, 0.9% @entity2827 injection, 5% @entity413 injection, 5% @entity413 and 0.45% @entity2827 injection, 5% @entity413 and 0.9% @entity2827 injection, 5% @entity413 with lactated Ringer's injection, lactated Ringer's injection, 5% @entity4388 injection, and 5% @entity413 injection with @entity4337 40 meq/L. One glass and one @entity2634 container of each solution (except glass only in the case of the solution in 5% @entity4388 injection) were stored in the dark at 5 degrees C, under ambient room light at 23-27 degrees C, in the dark at 40 degrees C, and under intense light at 25-30 degrees C. At storage intervals up to 168 hours, samples were tested for @entity7368 concentration by high-performance liquid chromatography. Optical density and pH were also measured. @entity7368 was stable in the various i.v. fluids for at least 168 hours when stored at 5 degrees C or 23-27 degrees C, for at least 24 hours when stored under intense light, and, with one exception, for at least 48 hours when stored at 40 degrees C. When mixed with 5% @entity4388 injection, the drug was stable for only about 24 hours at 40 degrees C. There were no substantial changes in optical density or pH. The type of container had no effect on stability. With one exception, @entity7368 was stable in all the i.v. solutions under all the conditions tested.
