Prognostic Value of Fat Mass and Skeletal Muscle Mass Determined by Computed Tomography in XXXX Who Underwent Transcatheter Aortic Valve Implantation.

@entity1 @entity28 @entity6288
UNASSIGNED: Body composition (fat mass [FM] and skeletal muscle mass [SMM]) predicts clinical outcomes. In particular, loss of SMM ( @entity6288 ) is associated with frailty and mortality. There are no data on the prevalence and impact of FM and SMM in @entity1 undergoing transcatheter aortic valve implantation (TAVI). The objective of this study is to determine body composition from pre-TAVI computed tomography (CT) and evaluate its association with clinical outcomes in @entity1 who underwent TAVI. A total of 460 @entity1 (mean age 81    8  years, @entity1 : 51%) were included. Pre-TAVI CTs of the aorto-ilio-femoral axis were analyzed for FM and SMM cross-sectional area at the level of the third lumbar vertebrae (L3). Regression equations correlating cross-sectional area at L3 to total body FM and SMM were used to determine prevalence of @entity6288 , @entity28 , and @entity28 in @entity1 (64%, 65%, and 46%, respectively). Most TAVI procedures were performed through a transfemoral approach (59%) using a balloon-expandable valve (94%). The 30-day and mid-term (median 12 months [interquartile range 6 to 27]) mortality rates were 6.1% and  29.6%, respectively. FM had no association with clinical outcomes, but @entity6288 predicted cumulative mortality (hazard ratio 1.55, 95% confidence interval 1.02 to 2.36, p  = 0.04). In  conclusion, body composition analysis from pre-TAVI CT is feasible. @entity6288 , @entity28 , and @entity28 are prevalent in the TAVI population, with @entity6288 predictive of cumulative mortality.
