Cardiovascular and biochemical risk factors for incident XXXX in the @entity101 in the Very Elderly Trial.

@entity1 @entity8 @entity712 @entity64 @entity101 @entity6 @entity303 @entity73 @entity4121 @entity955 @entity1011 @entity413 @entity165
OBJECTIVES: Several cardiovascular and biochemical factors including @entity101 have been associated with @entity73 and @entity303 , although both epidemiological and intervention evidence is mixed with the majority of studies examining those in midlife or younger elderly and the recent @entity101 in the Very Elderly Trial showing no significant association between blood pressure lowering and incident @entity303 . It has also been suggested that risk factors may differ in the very elderly. The aim of these analyses was to examine the impact of baseline cardiovascular and biochemical factors upon incident @entity303 and @entity73 in a very elderly @entity101 group. METHODS: @entity1 of the @entity101 in the Very Elderly Trial were aged at least 80 years and @entity101 . Cognitive function was assessed at baseline and annually with diagnostic information collected for @entity303 and relationships between baseline total and high-density lipoprotein @entity165 , @entity1011 , @entity413 , haemoglobin, @entity712 , @entity955 , @entity6 , previous @entity64 and later @entity303 / @entity73 were examined. RESULTS: There were 3336 @entity1 with @entity73 data. In multivariate analyses higher @entity1011 was associated with a lower risk of incident @entity303 and @entity73 . Higher total and lower high-density lipoprotein @entity165 were associated with lower risk of @entity73 . Other variables were not significant. CONCLUSIONS: In very elderly @entity101 @entity1 @entity712 , @entity6 , @entity955 , prior @entity64 , @entity413 and @entity4121 levels did not demonstrate a relationship with @entity73 or @entity303 . Higher @entity1011 (excluding moderate @entity8 ) was associated with a lower risk of @entity303 and @entity73 . The findings for total and high-density lipoprotein @entity165 add to the varied literature in this area and together these findings may add weight to the suggestion that risk factor profiles differ in the very elderly.
