XXXX in @entity1 receiving conventional treatment with insulin.

@entity1 @entity7965 @entity413 @entity6
The prevalence of nocturnal biochemical hypoglycaemia--that is, blood @entity413 concentrations below 3 mmol/l (55 mg/100 ml)--was evaluated in a random sample of 58 insulin dependent @entity6 receiving twice daily insulin. Seventeen @entity1 had at least one blood @entity413 value below 3 mmol/l (55 mg/100 ml) and five a value below 2 mmol/l (36 mg/100 ml) during the night. Both bedtime (2300) and fasting morning (0700) blood @entity413 concentrations were significantly lower in the group with @entity7965 compared with the group without (p less than 0.00001). If the bedtime blood @entity413 concentration was below 6 mmol/l (108 mg/100 ml) the risk of @entity7965 was 80% (95% confidence limits 51-96%). If the bedtime blood @entity413 concentration was above 6 mmol/l the likelihood of hypoglycaemia not occurring during the night was 88% (74-96%). The mean glycosylated haemoglobin A1c (HbA1c) concentration in the group with nocturnal biochemical hypoglycaemia (8.2 (range 5.0-12.4)%) was significantly lower than that in the group without (9.4(7.0-14.2)%) (p less than 0.02). The prevalence of @entity7965 in the @entity1 receiving twice daily insulin (29%) was compared with that in 15 @entity1 receiving thrice daily insulin (47%) and was not found to be significantly different. The likelihood of this risk being greater with thrice daily insulin was, however, 88%. No @entity1 with nocturnal biochemical hypoglycaemia woke up during the night with symptomatic hypoglycaemia. Nocturnal biochemical hypoglycaemia is common during twice daily treatment with insulin, and low values of HbA1c might be associated with a higher risk of such hypoglycaemia. The blood @entity413 concentration at bedtime is a significant predictor of nocturnal biochemical hypoglycaemia, and HbA1c values might be of help in identifying @entity1 at risk.
