@entity5822 negative invasive XXXX : clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.

@entity1 @entity0 @entity5473 @entity7273 @entity189 @entity513 @entity5822 @entity3 @entity1722
@entity5822 ( @entity5822 ) negative @entity0 are reported to occur rarely. We studied 14 @entity5822 negative cases of @entity513 ( @entity513 ) detected during sentinel lymph node @entity3 work-up and immunohistochemistry panel in the work-up of metastatic @entity189 . Axillary lymph node @entity3 were present in seven @entity1 (50%). Oestrogen receptor (ER) was strongly positive in all cases: @entity7273 in 78%, @entity1722 in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases. @entity3 and/or recurrence were found in 8 of 14 @entity1 (57%) with the mean clinical follow-up of 55   months. @entity3 sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 @entity1 received adjuvant chemotherapy. All 14 @entity1 received hormonal therapy and radiation therapy. Morphologically, @entity513 with neuroendocrine features was noted in 57%. @entity5473 stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these @entity5822 negative @entity0 were ER positive, mostly @entity1722 negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.
