Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis XXXX : A Comparison between Plaque and Guttate Psoriasis.

@entity1 @entity1569 @entity13236 @entity1193 @entity4155 @entity379 @entity1199 @entity4452
BACKGROUND: The phenotypic heterogeneity of @entity1569 could be explained by the alternate activation of either T-helper (Th)-1- or Th-17-related cytokines. However, evidence directly supporting this hypothesis is scarce. OBJECTIVE: To characterize the expression of Th-1- and Th-17-related cytokines according to the morphological @entity1569 phenotype: guttate vs. plaque. METHODS: In this study, we enrolled 68 @entity1 exhibiting either guttate or @entity1569 , and 10 healthy controls. To avoid age-related bias, age matching was performed for each group. Circulating levels of @entity379 , @entity1193 , @entity1199 , IL-12p40, @entity4155 , @entity13236 , and @entity4452 were measured with an enzyme-linked immunosorbent assay (ELISA). Psoriasis-affected tissue was obtained through biopsy sampling from the eight @entity1 who exhibited the most typical morphology. Levels of @entity1193 , IL-12p40, @entity4155 , @entity13236 , and @entity4452 in the @entity1569 tissue samples were measured with western blot analysis. RESULTS: ELISAs of the serum samples showed higher levels of inflammatory cytokines such as @entity1193 , @entity1199 , @entity4452 , and @entity379 in @entity1 with @entity1569 than in healthy controls. However, the inflammatory cytokine levels did not differ significantly between guttate and @entity1569 @entity1 . Western blot analysis of psoriatic tissue revealed higher protein levels of Th-1- and Th-17-related cytokines in @entity1 than in healthy controls. The levels of IL-12p40 and @entity4452 were unexpectedly higher in plaque tissue than in guttate tissue. CONCLUSION: The morphological phenotype of @entity1569 does not appear to be determined by a specific activation of either the Th-1 or Th-17 pathway. Rather, the cytokine profile influences disease activity and is altered according to the status of the lesion (early or chronic).
