Prenatal Risk Factors and Outcomes in XXXX : A Meta-Analysis.

@entity154 @entity2978 @entity6675 @entity1146 @entity204 @entity6676
BACKGROUND AND OBJECTIVE: @entity6675 is a @entity154 with increasing incidence, easy prenatal diagnosis and extremely variable postnatal outcomes. Our objective was to systematically review the evidence regarding the association between prenatal ultrasound signs (intraabdominal bowel dilatation [IABD], extraabdominal bowel dilatation, @entity6676 [ @entity6676 ], bowel wall thickness, @entity2978 , and small for gestational age) and perinatal outcomes in @entity6675 (bowel @entity1146 , intra uterine @entity204 , @entity204 , time to full enteral feeding, length of total parenteral nutrition and length of in hospital stay). METHODS: Medline, Embase, and Cochrane databases were searched electronically. Studies exploring the association between antenatal ultrasound signs and outcomes in @entity6675 were considered suitable for inclusion. Two reviewers independently extracted relevant data regarding study characteristics and pregnancy outcome. All meta-analyses were computed using individual data random-effect logistic regression, with single study as the cluster unit. RESULTS: Twenty-six studies, including 2023 fetuses, were included. We found significant positive associations between IABD and bowel @entity1146 (odds ratio [OR]: 5.48, 95% confidence interval [CI] 3.1-9.8), @entity2978 and bowel @entity1146 (OR: 3.76, 95% CI 1.7-8.3), and @entity6676 (OR: 5.58, 95% CI 1.3-24.1). No other ultrasound sign was significantly related to any other outcome. CONCLUSIONS: IABD, @entity2978 , and @entity6676 can be used to an extent to identify a subgroup of neonates with a prenatal diagnosis of @entity6675 at higher risk to develop postnatal complications. Data are still inconclusive on the predictive ability of several signs combined, and large prospective studies are needed to improve the quality of prenatal counseling and the neonatal care for this condition.
