CNS Depressant and Antinociceptive Effects of Different Fractions of Pandanus Foetidus Roxb. Leaf Extract in XXXX .

@entity308 @entity137 @entity19 @entity1042 @entity1337 @entity406 @entity3636 @entity8144 @entity1372 @entity2915 @entity158
BACKGROUND: Various parts of Pandanus foetidus Roxb. are used as traditional medicines. However, scientific reports concerning the effect of this plant on central nervous system (CNS) @entity308 and @entity1337 are unavailable. This study investigated the CNS depressant and antinociceptive effects of Pandanus foetidus leaf extracts in a rodent model. METHODS: The sedative and anxiolytic activities of Pandanus foetidus extract (500 g) were tested using behavioural models of Swiss albino @entity19 , and the analgesic activity was assessed by @entity406 -induced @entity158 and tail immersion tests at 200 mg/kg body weight of the @entity19 . The data were analysed by a one-way ANOVA, a repeated measure of ANOVA and a non-parametric test (Kruskal-Wallis test) using the SPSS software. Acute @entity137 was tested using an established method. RESULTS: Compared with the aqueous fraction, the @entity1042 , @entity8144 and @entity3636 fractions of the extract exhibited a more significant (P < 0.001) @entity2915 in the @entity19 in the open field, hole-cross, and elevated plus maze (EPM). The @entity1042 fraction maximized the duration of sleeping time caused by the thiopental @entity1372 induction. The extract produced a significant step-down in @entity158 , as shown by the paw licking time in the early and late phases of the @entity406 test. In the tail immersion test, the @entity3636 fraction maximally reduced the heat-induced @entity1337 . The extract was found to be non toxic. CONCLUSION: The @entity1042 , @entity8144 , and @entity3636 fractions of P. foetidus have strong CNS depressant and antinociceptive effects and thus merit further pharmaceutical studies.
