Catheter-directed thrombolysis of proximal lower extremity XXXX : a prospective trial with venographic and clinical follow-up.

@entity1150 @entity1 @entity715
PURPOSE: To prospectively evaluate the primary and long-term venographic and clinical results of catheter-directed thrombolysis in the treatment of proximal @entity1150 ( @entity1150 ) of lower extremity. MATERIALS AND METHODS: Fifty-six @entity1 with mean age of 48 (range 15-81) years with acute @entity1150 (symptom duration of less than 2 weeks), extending to high femoral (16 @entity1 ) or iliac vein (40 @entity1 ) were treated with selective catheter-directed thrombolysis. The mean total dose of 3.8 (range 1.0-8.1) million units of urokinase was administered during a mean of 39 (range 6-72) hours. Endovascular stenting was performed in 9 of the iliac @entity1150 @entity1 . RESULTS: Complete procedural venographic success was achieved in 79% of @entity1 . Major complications were noted in 7% of @entity1 and the total rate of complications was 13%. Mean venographic follow-up was 3.5 years (range 3 months to 9.6 years); well preserved femoral vein valves and fully recanalized deep crural veins were observed in 83% and 57% of @entity1 . Normal clinical findings in the affected limb were noted during the latest follow-up visit in 67% of @entity1 . Clinical @entity715 occurred in 9% of @entity1 . CONCLUSION: Catheter-directed thrombolysis achieves good primary success with acceptable complication rate and effectively reduces prevalence of @entity715 .
