Yiqihuoxuejiedu Formula Restrains Vascular Remodeling by Reducing the Inflammation Reaction and XXXX Expression in the Adventitia after @entity130 .

@entity32 @entity4647 @entity101 @entity35 @entity1373 @entity6980 @entity10277 @entity22519 @entity1317 @entity731 @entity130
Vascular remodeling is closely related to @entity101 , @entity731 , and restenosis after PCI. Considerable evidence indicates that the activation and proliferation of adventitial fibroblasts play key roles in @entity130 . The inflammatory response and high expression of connexins contribute to adventitial remodeling. Therefore, reducing @entity32 reaction and connexins expression in adventitia may become a new target to prevent @entity6980 . Yiqihuoxuejiedu formula, composed of TCM therapeutic principle of supplementing qi, activating blood and detoxification, can inhibit restenosis after @entity130 . To further investigate the effect of Yiqihuoxuejiedu formula on @entity32 and connexins, we established a carotid @entity1317 model. In model @entity35 , @entity1373 in the intima was mild but obvious in the adventitia; CRP heightened; expressions of @entity4647 , @entity22519 , and @entity10277 increased. Yiqihuoxuejiedu formula relieved intimal @entity1373 and adventitial area, obviously diminished the expressions of @entity22519 and @entity10277 in the adventitia, and reduced CRP but did not lower @entity4647 . These results indicated that Yiqihuoxuejiedu formula inhibited @entity6980 especially @entity1373 by reducing the @entity32 reaction including lowering macrophages infiltration and systemic nonspecific inflammatory response and also restraining gap junction connexins leading to less communication among cells. This study provides new ideas and methods for the prevention and treatment of @entity6980 .
