XXXX manifested in childhood with special reference to various types of reversible @entity1375 .

@entity1 @entity1375 @entity1496 @entity851 @entity1032 @entity10972 @entity71198 @entity1374
The clinical course of 15 @entity1 with overt @entity1375 manifested in childhood were studied. Nine female @entity1 with @entity1375 due to @entity10972 showed almost normal height and became euthyroid spontaneously during @entity1496 restriction. The other 6 nongoitrous @entity1 (3M and 3F) ( @entity1374 in 2, @entity71198 in 2 and probable hypoplastic thyroid in 2) showed physical @entity851 and remained irreversibly @entity1375 requiring replacement therapy. In the reversible group, the characteristic findings were high thyroidal radioactive @entity1496 uptake (58 +/- 19%/24 h, N = 8) and positive perchlorate discharge test. Serum nonhormonal @entity1496 levels were high in 4 of 6 @entity1 measured. During the long-term follow-up period of 6 years in 6 @entity1 , 2 @entity1 remained euthyroid with normal growth and regular menstrual cycle and 4 @entity1 became @entity1375 again (after eating seaweed in 1, despite @entity1496 restriction in 2 and after the episode of @entity1374 in 1). @entity1032 of growth was observed during the second episode of @entity1375 . In the irreversible group, one @entity1 with blocking type TSH binding inhibitor immunoglobulin (TBII) became thyrotoxic 4 years later with the decrease in activity of blocking type TBII. These results suggested that reversible recovery of the thyroid function could be expected in @entity1 with @entity1375 due to @entity10972 after (1) @entity1496 restriction, (2) improvement of immunological perturbation, or (3) disappearance of blocking type TBII. However, careful follow-up is necessary, because @entity1375 would recur again with transient retardation of growth in @entity1 .
