XXXX and pregnancy.

@entity1 @entity5 @entity1066 @entity911 @entity204 @entity320
@entity911 exists concerning the influence of pregnancy on survival in @entity1 with @entity320 . To evaluate this problem a retrospective computer-aided study was performed of @entity1 in the @entity1 -bearing years treated for Stage I cutaneous @entity320 at the Duke University Comprehensive @entity5 Center. Fifty-eight @entity1 were identified who had @entity320 arise during pregnancy (Group 1) and 43 @entity1 were noted who became pregnant within 5 years of diagnosis of their @entity320 (Group 2). Appropriate control groups matched for the clinical variables of age, primary site, and stage of disease and the pathologic variables of Clark's Level, @entity5 thickness, @entity1066 , and histologic type were selected from the cohort of 2938 @entity320 @entity1 seen at Duke. Actuarial survivals for Group 1 and 2 @entity1 did not differ from their respective controls, although the small number of @entity204 in each group resulted in wide confidence intervals. When actuarial disease-free intervals were plotted, there was a significant difference between @entity1 who had @entity320 develop during pregnancy when compared to their controls (P = 0.04). In a multivariate regression analysis, after adjustment for the influence of the more significant prognostic factors for Stage 1 @entity320 , including Clark's Level, @entity1066 and @entity5 thickness, the effect of pregnancy on disease-free interval became more apparent (P = 0.02). No difference in actuarial disease-free interval was noted in the @entity320 @entity1 who elected to become pregnant within 5 years of diagnosis (P = 0.31). A multivariate regression analysis confirmed this finding. These data indicate that although an intercurrent @entity320 during pregnancy has a worse prognosis than the control groups, once a @entity1 has been diagnosed as having a cutaneous @entity320 , a subsequent pregnancy has no effect on recurrence rate or survival.
