The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in XXXX .

@entity1 @entity101 @entity28 @entity1184 @entity1283 @entity13519 @entity4346 @entity299 @entity1556
BACKGROUND: @entity101 and @entity28 in childhood are related to early @entity299 , as @entity4346 . Few studies have analyzed the independent effects of @entity101 and weight excess on diastolic function and left ventricular geometry. OBJECTIVE: We studied the effects of weight, waist circumference (as an index of fat distribution) and blood pressure on left ventricular mass index, the risk of @entity4346 , diastolic function and left ventricular geometry in 526 @entity1 (237 @entity1 , age range 6-15 years). METHODS: @entity1 were divided into normotensive, prehypertensive and @entity101 (US Nomograms) groups, and into normal-weight, overweight, and @entity28 (International @entity28 Task Force classification) groups. Left ventricular mass index, diastolic function and left ventricular geometry were assessed. RESULTS: @entity13519 z-scores and blood pressure categories significantly influenced cardiac mass (P<0.001 and P=0.02, respectively) and the prevalence of @entity4346 (P<0.001 and P<0.05, respectively). @entity28 , BMI, and waist circumference z-scores were significantly associated with an increment in E/Em ratio (P<0.001, P<0.01, and P<0.01, respectively). Increasing blood pressure values and the presence of @entity1556 (P<0.05) and @entity101 (P<0.003), but not weight excess, were associated with @entity299 . In contrast, concentric @entity1184 was associated with @entity101 (P<0.01), @entity28 (P<0.001), and increasing waist circumference (P<001). CONCLUSIONS: Blood pressure values and @entity101 are independently associated with an increase of cardiac mass and the presence of @entity1283 . @entity28 and waist circumference, but not @entity101 , are associated with a worsening of diastolic function, whereas only @entity101 @entity1 show high prevalence of concentric remodeling. Blood pressure and body weight and fat distribution have an independent and different impact on left ventricular structure and function in @entity1 .
