Impact of @entity6 duration on the extent and severity of coronary atheroma burden and long-term clinical outcome in asymptomatic type 2 @entity6 XXXX : evaluation by Coronary CT angiography.

@entity1 @entity64 @entity583 @entity6 @entity460 @entity1856 @entity453 @entity850
AIMS: We investigated the association between @entity6 duration and the extent and severity of @entity453 ( @entity453 ) as well as long-term clinical outcomes using coronary computed tomography angiography (CCTA) in asymptomatic type 2 @entity6 @entity1 . METHODS AND RESULTS: We analysed 933 asymptomatic type 2 @entity6 @entity1 without known @entity453 who underwent CCTA. @entity1 were divided into three groups according to the duration of @entity6 : <5 years, 5-10 years, and >= 10 years. Stenosis by CCTA was scored as none (0%), non-obstructive (1-49%), or obstructive (>= 50%) for each coronary artery segment. For these @entity1 , we compared the prevalence, extent, and severity of @entity453 , including coronary artery @entity460 score (CACS), @entity1856 burden obstructive score (ABOS), segment involvement score (SIS), and segment @entity850 score (SSS). Major adverse cardiac and cerebrovascular events (MACCE), including all-cause mortality, non-fatal @entity583 , and @entity64 , within a follow-up period were also compared. @entity1 with longer duration of @entity6 possessed higher rates of obstructive @entity453 (P < 0.001). @entity1 with longer duration of @entity6 also manifested greater degree of CACS, ABOS, SIS, and SSS (P < 0.001 for all) with associated higher rate of MACCE (P = 0.025). Presence of obstructive @entity453 as assessed by CCTA was an independent predictor of MACCE after adjusting for confounding risk factors (hazard ratio: 1.979, confidence interval: 1.178-3.327, P = 0.010). CONCLUSION: In asymptomatic @entity6 @entity1 , longer @entity6 duration is associated with a higher prevalence, extent, and severity of @entity453 as well as risk of MACCE. Moreover, greater @entity453 burden increases the risk of MACCE independent of co-existing @entity453 risk factors.
