Synergistic activity of @entity18943 and cytotoxic drugs against XXXX cell lines.

@entity9984 @entity788 @entity5 @entity98 @entity18943 @entity136 @entity1487
BACKGROUND: @entity18943 ( @entity9984 ) is growth inhibitory both in vitro and in vivo, at doses non-toxic to non- @entity5 cells. Chemotherapeutic agents have limited activity in @entity788 . Interactions between @entity9984 and cytotoxic drugs have not previously been investigated; any synergy might improve the therapeutic effect of these agents. AIM: To investigate possible interactions between @entity9984 and @entity1487 ( @entity1487 ) or @entity136 against @entity788 cell lines in vitro. METHODS: Two @entity788 cell lines were exposed to @entity9984 alone and in combination with @entity1487 or @entity136 . Residual viable biomass was measured using the @entity98 assay and the results analysed by the median effect method of Chou and Talalay [Adv Enzyme Regul 1984;22:27-55]. RESULTS: @entity9984 concentrations of 3.9- 125 microg/ml had a synergistic or additive growth inhibitory effect on all tested concentrations of @entity136 . Synergism was demonstrated between @entity9984 and @entity1487 only at concentrations of 62.5-125 microg/ml of @entity1487 . CONCLUSION: @entity9984 has a synergistic effect with @entity136 at concentrations that correspond to in vivo therapeutic doses. @entity9984 with @entity1487 is synergistic only at a tight range of high concentrations of @entity1487 . @entity9984 lacks toxic side effects and may be useful in combination with @entity136 .
