Properties and biosynthesis of a XXXX protein of the venoms of s snakes Laticauda laticaudata and Laticauda colubrina.

@entity5808 @entity1522 @entity535 @entity19 @entity2359 @entity934
1. A @entity2359 protein similar to erabutoxins a and b of Laticauda semifasciata was isolated in crystalline form from the venoms of Laticauda laticaudata and Laticauda colubrina. The name ;laticotoxin a' is proposed. 2. Laticotoxin a is homogeneous by CM-cellulose column chromatography, disc electrophoresis and ultracentrifugation and by terminal @entity535 analyses. 3. Laticotoxin a consists of 62 @entity535 residues. The molecular weight by ultracentrifuging is 6520. 4. The minimal 50% lethal dose of laticotoxin a by intramuscular injection to @entity19 is 0.13mug./g. body wt. The toxin attacks the postsynaptic membrane, competing with @entity934 . 5. Radioactive @entity1522 are incorporated into laticotoxin a in vivo. The incorporation is inhibited by @entity5808 , suggesting that the biosynthesis of the toxin follows the mechanism of protein biosynthesis, although the toxin molecule is rather small as a protein.
