XXXX in @entity1358 variants detected by Urovysion fluorescence in situ hybridization on paraffin-embedded tissue.

@entity1 @entity1637 @entity5 @entity189 @entity1358 @entity982 @entity2008 @entity703
Urovysion fluorescence in situ hybridization (UVFISH) identifies malignant cells in urine by detecting specific @entity189 -related @entity2008 . Some @entity703 ( @entity703 ) share overlapping chromosomal aberrations with @entity189 . Malignant renal cells that are shed in urine can potentially cause a positive UVFISH result. We evaluated UVFISH in @entity703 to determine its potential applicability to the diagnosis and grading of @entity703 . @entity982 blocks from 39 @entity703 (25 clear cell, 9 papillary, 2 chromophobe, and 3 sarcomatoid) and 15 controls (5 renal @entity1637 and 10 @entity189 ) were tested. Of the @entity703 , 15 (40%) were UVFISH-positive (9/25 [40%] clear cell, 3/9 [30%] papillary, 1/2 [50%] chromophobe, and 2/3 [67%] @entity189 ) and 24 (60%) were negative. Of the 15 controls, 8 (   50%) were UVFISH-positive (2/5 [40%] @entity1637 and 6/10 [60%] @entity189 ) and 7 (   50%) were UVFISH-negative. Polysomy of chromosome 17 showed a statistically significant correlation with @entity1358 subtype, being absent in most of the clear cell @entity703 (P = .0096) compared with other @entity703 . Polysomy of chromosome 7 was more frequent in high-grade than low-grade @entity1358 (P = .0197) and more likely in high-grade clear cell than low-grade clear cell @entity1358 (P = .0120). In conclusion, we showed that @entity1358 has overlapping @entity2008 with @entity189 and can cause a positive UVFISH result. This has implications for the interpretation of Urovysion in @entity1 whose urine contains malignant cells but who have negative cystoscopy and a concomitant renal mass. The @entity2008 observed in @entity1358 are not distinct from those in @entity189 ; therefore, UVFISH cannot distinguish these @entity5 types, nor can it type or grade @entity1358 .
