Predictive value of post-transplant bone marrow plasma cell percent in @entity1582 XXXX undergone autologous transplantation.

@entity1 @entity632 @entity19 @entity262 @entity1582 @entity619 @entity1891 @entity1349
BACKGROUND/AIMS: Autologous stem cell transplantation (ASCT) has become the treatment of choice for @entity1 with @entity1582 ( @entity1582 ). Studies have shown that maintenance treatment with interferon-alpha is associated with improved survival rates following ASCT. However, despite these recent advances in regimes, relapses are inevitable; thus, the prediction of relapse following ASCT requires assessment. METHODS: We retrospectively analyzed 39 @entity1 who received ASCT between 2003 and 2008. All @entity1 received chemotherapy with @entity1891 , @entity632 , and @entity619 (VAD), and ASCT was performed following high-dose melphalan conditioning therapy. We evaluated the influence of the post-transplant day +14 ( @entity19 ) bone marrow plasma cell percent (BMPCp) (>=  2 vs. < 2%), @entity262 ( @entity262 ) stage (II vs. III), response after 3 cycles of VAD therapy (complete response [CR] vs. non-CR), deletion of chromosome 13q (del[13q]) (presence of the abnormality vs. absence), and BMPCp at diagnosis (>=  50 vs. < 50%) on progression-free survival (PFS) and @entity1349 ( @entity1349 ). RESULTS: During the median follow-up of 28.0 months, the median PFS and @entity1349 were 29.1 and 42.1 months, respectively. By univariate analysis, @entity262 stage III at diagnosis, BMPCp >=  50% at diagnosis, CR after 3 cycles of VAD therapy, del (13q) by fluorescence in situ hybridization, and BMPCp >=  2% at post-transplant D+14 were correlated with PFS and @entity1349 . A multivariate analysis revealed that a post-transplant D+14 BMPCp >=  2% (PFS, hazard ratio [HR] = 4.426, p = 0.008; @entity1349 , HR = 3.545, p = 0.038) and CR after 3 cycles of VAD therapy (PFS, HR = 0.072, p = 0.014; @entity1349 , HR = 0.055, p = 0.015) were independent prognostic parameters. CONCLUSIONS: Post-transplant D+14 BMPCp is a useful parameter for predicting the outcome for @entity1 with @entity1582 receiving ASCT.
