The influence of XXXX @entity38927 and lifetime sun exposure on the risk of actinic keratoses, @entity4891 , @entity8205 , @entity1489 .

@entity4891 @entity1489 @entity957 @entity8205 @entity38927 @entity7174 @entity158 @entity320 @entity1491
@entity158 are implicated in the pathogenesis of @entity957 , @entity1491 , and @entity320 . Chronic exposure to ultraviolet radiation is known as the most important risk factor for the development of actinic keratoses and @entity957 . The purpose of the study was to assess the effect of @entity158 @entity38927 and lifetime sun exposure on the development of actinic keratoses and @entity4891 in relation to the development of @entity957 and @entity1491 , and on the development of @entity8205 and @entity7174 in relation to the development of @entity320 . We made use of a cohort of 966 individuals who participated in a case-control study to investigate environmental and genetic risk factors for @entity1489 . Exposure measurements for sunlight were collected and actinic keratoses, @entity4891 , @entity8205 , and @entity7174 were counted. Relative risks were estimated using exposure odds ratios from cross-tabulation. Multivariate logistic regression was used to adjust for potential confounders. The recall of @entity158 @entity38927 before the age of 20 y was associated with an increased risk of @entity957 , @entity1491 , and @entity1491 as well as actinic keratoses. Odds ratios with 95% confidence intervals adjusted for age, sex, and skin type were 1.5 (0.97; 2.3); 1.6 (1.1; 2.2); 2.6 (1.7; 3.8); and 1.9 (1.4; 2.6) for the three types of @entity1489 and actinic keratoses, respectively. @entity158 before the age of 20 y were also associated with an increased risk of @entity320 and the development of its precursors, @entity8205 and @entity7174 . Odds ratios with 95% confidence intervals adjusted for age, sex, and skin type were 1.4 (0.86; 2.1); 1.5 (1.1; 2.0); and 1.4 (0.88; 2.3) for @entity320 and the two types of precursors, respectively. Lifetime sun exposure was predominantly associated with an increased risk of @entity957 (p-value for trend=0.03) and actinic keratoses (p-value for trend <0.0001) and to a lesser degree with the two types of @entity1491 . By contrast, lifetime sun exposure appeared to be associated with a lower risk of @entity320 , despite the fact that lifetime sun exposure did not diminish the number of @entity8205 or @entity7174 . Neither @entity158 @entity38927 nor lifetime sun exposure were associated with an increased risk of @entity4891 .
