The Association of Polymorphisms in Leptin/Leptin Receptor Genes and Ghrelin/ XXXX Genes With Overweight/Obesity and the Related Metabolic Disturbances: A Review.

@entity13156 @entity6 @entity28 @entity13159 @entity1243 @entity59126 @entity5739 @entity29425 @entity209 @entity4334 @entity14950
CONTEXT: Leptin and ghrelin are two important appetite and energy balance-regulating peptides. Common polymorphisms in the genes coding these peptides and their related receptors are shown to be associated with body weight, different markers of @entity28 and @entity209 . This review article aims to investigate the association of common polymorphisms of these genes with overweight/ @entity28 and the @entity209 related to it. EVIDENCE ACQUISITION: The keywords leptin, ghrelin, polymorphism, single-nucleotide polymorphism (SNP), @entity28 , overweight, Body Mass Index, @entity209 , and @entity6 ( @entity6 ) (MeSH headings) were used to search in the following databases: Pubmed, Sciencedirect (Elsevier), and Google scholar. Overall, 24 case-control studies, relevant to our topic, met the criteria and were included in the review. RESULTS: The most prevalent leptin/leptin receptor genes ( @entity1243 / @entity13156 ) and ghrelin/ @entity14950 genes ( @entity5739 / @entity14950 ) single @entity4334 polymorphisms studied were @entity1243 @entity29425 , @entity13156 @entity13159 , and @entity59126 , respectively. Nine studies of the 17 studies on @entity1243 / @entity13156 , and three studies of the seven studies on @entity5739 / @entity14950 showed significant relationships. CONCLUSIONS: In general, our study suggests that the association between @entity1243 / @entity13156 and @entity5739 / @entity14950 with overweight/ @entity28 and the related @entity209 is inconclusive. These results may be due to unidentified gene-environment interactions. More investigations are needed to further clarify this association.
