@entity4538 @entity688 promotes proliferation and XXXX cells.

@entity1 @entity10772 @entity12791 @entity0 @entity5 @entity4538 @entity3 @entity688
UNASSIGNED: @entity0 is the most common @entity5 affecting @entity1 worldwide. While a small fraction of @entity0 have a hereditary component, environmental and behavioral factors also impact the development of @entity5 . @entity4538 ) is a member of the Herpesviridae family that is widespread in the general population and has been linked to several forms of @entity5 . While HCMV DNA has been found in some @entity0 tissue specimens, we wanted to investigate whether a secreted viral cytokine might have an effect on cancerous or even pre-cancerous cells. HCMV encodes an ortholog of the @entity1 cellular cytokine @entity688 ( @entity688 ). The HCMV UL111A gene product is cmvIL-10, which has 27% sequence identity to @entity688 and binds the cellular @entity10772 ( @entity10772 ) to induce downstream cell signaling. We found that MCF-7 @entity1 @entity0 cells express @entity10772 and that exposure to cmvIL-10 results in enhanced proliferation and increased chemotaxis of MCF-7 cells. PCR arrays revealed that treatment with cmvIL-10 alters expression of cell adhesion molecules and increases MMP gene expression. In particular, @entity12791 gene expression was found to be significantly up-regulated and this correlated with an increase in cell-associated @entity12791 protein produced by MCF-7 cells exposed to cmvIL-10. These results suggest that the presence of cmvIL-10 in the @entity5 microenvironment could contribute to the development of more @entity3 .
