XXXX as a novel downstream target of @entity319 in @entity11 -tropic neural stem cells.

@entity7 @entity5 @entity1313 @entity1050 @entity1551 @entity319 @entity11 @entity4178 @entity3818
UNASSIGNED: Neural stem cell (NSC)-based carriers have been presented as promising therapeutic tools for the treatment of infiltrative @entity1313 due to their intrinsic @entity5 homing property. They have demonstrated the ability to migrate towards distant @entity5 microsatellites and effectively deliver the therapeutic payload, thus significantly improving survival in experimental animal models for @entity1313 . Despite such optimistic results, the efficacy of NSC-based anti- @entity5 therapy has been limited due to the restricted @entity5 homing ability of NSCs. To examine this issue, we investigated the mechanisms of @entity5 -tropic migration of an FDA-approved NSC line, @entity4178 .F3. @entity1050 , by performing a gene expression analysis. We identified @entity7 ( @entity7 ) and membrane-bound matrix metalloproteinase ( @entity1551 ) as molecules whose expression are significantly elevated in migratory NSCs. We observed increased expression of @entity319 ( @entity319 ) in the focal adhesion complexes of migratory NSCs, with downstream activation of @entity319 -dependent kinases such as p-PLCy, p- @entity3818 , and p-Akt, a signaling cascade reported to be required for cellular migration. In an in vivo @entity11 xenograft model, analysis of the migratory trail showed that NSCs maintained expression of @entity319 and preferentially migrated within the perivascular space. Knockdown of @entity319 via shRNAs led to significant downregulation of @entity1551 expression, which resulted in inhibited @entity5 -tropic migration. Overall, our results suggest, the involvement of @entity319 -regulated @entity1551 in the @entity5 -tropic migratory behavior of NSCs. Our data warrant investigation of @entity1551 as a target for enhancing the migratory properties of NSC carriers and optimizing the delivery of therapeutic payloads to disseminated @entity5 burdens.
