Thyroid hormone regulation of XXXX receptor subunit mRNA expression in adult brain.

@entity1 @entity1375 @entity1024 @entity2227 @entity4319 @entity8036 @entity73 @entity4476 @entity4860 @entity4474 @entity1378 @entity4176 @entity143 @entity140 @entity35 @entity6145
Thyroid hormone is an essential modulator of brain development, but little is known about its actions in the adult brain. @entity1375 is associated with gene expression changes in both central and peripheral nervous tissue. Functional consequences of adult-onset @entity1375 include an inability to produce long-term potentiation in @entity35 hippocampus and @entity73 in both @entity35 and @entity1 . Long-term potentiation is a form of learning that is dependent on functional @entity1024 ( @entity143 )-preferring ionotropic @entity2227 receptors. This work examines the expression of ionotropic @entity2227 receptor subunit mRNA following surgical thyroidectomy with or without @entity6145 replacement. In situ hybridization histochemistry was used to determine the mRNA levels of the @entity143 receptor subunits @entity4474 , @entity4476 , @entity4319 , the @entity140 receptor subunit @entity4860 , and the @entity4176 receptor subunit @entity8036 . Reducing circulating concentrations of thyroid hormone by surgical removal of the thyroid gland 2 weeks before sacrifice decreased the expression of @entity4474 mRNA exclusively in the hippocampus. Conversely, @entity1378 selectively reduced @entity4319 mRNA expression in the dorsal hippocampus. Altering thyroid hormone status had no effect on the expression of @entity8036 or @entity4860 subunit mRNA. The regulation of expression of @entity4474 and @entity4319 mRNA by thyroid hormone is a novel mechanism for explaining the relationship between thyroid hormone and cognitive function.
