Vascular risk factors in XXXX , adolescents, and young adults with @entity1723 complicated by celiac disease: results from the DPV initiative.

@entity1 @entity1723 @entity1593 @entity6
OBJECTIVE: @entity1593 ( @entity1593 ) is a common comorbidity of @entity1723 ( @entity1723 ). Long-term consequences of @entity1593 are not completely understood, and adhering to a gluten-free diet is a burden for many @entity1 . We investigated the effect of @entity1593 on vascular risk factors in a large cohort of @entity1723 @entity1 aged <20   yr. RESEARCH DESIGN AND METHODS: Within the @entity6 (DPV)- @entity6 registry, data were analyzed from 59   909   <   20-yr-old @entity1723 @entity1 treated at 392 centers in Germany and Austria. A total of 974 @entity1 with @entity1593 ( @entity1593 ) were compared with 28   398 @entity1 without @entity1593 with respect to blood pressure (BP), lipids, glycohemoglobin (HbA1c ), body mass index (BMI), and reported smoking behavior. RESULTS: @entity1 with @entity1723 and @entity1593 showed significantly lower high-density lipoprotein (HDL) cholesterol levels [median (interquartile range): 53.0 (43.0-62.6)   mg/dL] than @entity1 without @entity1593 [55.0 (45.0-66.0)   mg/dL; p   <   0.01; p   <   0.001 after adjustment for confounding variables]. Systolic BP was lower in @entity1 with @entity1593 [105.5 (100.0-112.5) mmHg] than in @entity1 without @entity1593 [110.0 (102.0-117.0) mmHg; p   <   0.0001; p   <   0.001 after adjustment]. There were no significant differences regarding smoking behavior, BMI, or HbA1c . In a subgroup of 335 @entity1 with @entity1593 , HDL cholesterol was measured 1 yr after diagnosis of @entity1593 :HDL increased by 8% (p   <   0.01). CONCLUSION: Young @entity1 with @entity1723 and @entity1593 have lower HDL cholesterol values than @entity1 without @entity1593 . As low HDL cholesterol is associated with vascular risk, our findings support screening for @entity1593 and monitoring of HDL cholesterol in young @entity1 with @entity1723 .
