Uterine XXXX (UPSC): a single institution review of 129 cases.

@entity1 @entity1377 @entity0 @entity5 @entity3
OBJECTIVE: The aim of this study was to identify clinical and pathologic characteristics of @entity1 with uterine @entity1377 (UPSC) who were all surgically managed at a single institution. The identified characteristics were then correlated with overall survival (OS). METHODS: One hundred twenty-nine @entity1 with FIGO stage I-IV UPSC who were surgically staged at the University of Texas M. D. Anderson @entity5 Center between 1989 and 2002 were identified. For each @entity1 , medical records and pathology reports were reviewed. The Kaplan-Meier method was used to generate OS data. Factors predictive of outcome were compared using the log-rank test and Cox regression analysis. RESULTS: There were 52 @entity1 with stage I disease, 5 with stage II, 41 with stage III, and 31 with stage IV. The median age at the time of diagnosis was 68 years (range, 44-93 years). A personal history of @entity0 was reported by 12.4% of the @entity1 , and a family history of @entity0 was reported by 16%. The 5-year OS among all @entity1 was 45.9%. Among the stage I @entity1 (IA, n = 19; IB, n = 26; and IC, n = 7), the 5-year OS was 62.9% (IA, 81.5%; IB, 58.6%; and IC, 34.3%). The 5-year OS for @entity1 with stage III and IV disease was 37.3 and 19.9%, respectively. Pathologic features predictive of OS included lymph node status (P </= 0.01), lymph vascular invasion (P </= 0.05), and depth of uterine invasion (P </= 0.05). Among @entity1 with no uterine invasion (n = 32), surgical staging revealed that 37% had stage III or IV disease. Among stage III @entity1 , those who received chemotherapy had a longer OS than those who did not receive chemotherapy (P = 0.03). CONCLUSION: In this population of nonselected @entity1 with UPSC, approximately 20% had a personal or family history of @entity0 . Stage, lymph node status, lymph vascular invasion, and depth of @entity3 were all risk factors for a worse prognosis. Traditional risk factors, however, did not predict the presence or the absence of @entity3 . Among @entity1 with noninvasive uterine disease, there was a high proportion with abdominal @entity3 . Therefore, complete surgical staging of these @entity1 is vital in determining their prognosis.
