Evaluation of Serum XXXX ( @entity4155 ) Levels as a Diagnostic Marker in @entity788 .

@entity1 @entity788 @entity5 @entity4155 @entity3
BACKGROUND: Inflammatory cytokines modulate immune responses in the @entity5 microenvironment during progression. The role of @entity4155 ) in @entity5 is currently under debate. This study was conducted to investigate the serum levels of @entity4155 in @entity1 with @entity788 ( @entity788 ) and the relationship with @entity5 progression and known prognostic parameters. MATERIAL AND METHODS: Thirty-five @entity1 with @entity788 were investigated. Serum samples were obtained on first admission before treatment and follow-up. Both serum @entity4155 levels were determined using enzyme-linked immunosorbent assay (ELISA). Age- and sex-matched 35 healthy controls were included in the analysis. RESULTS: The median age at diagnosis was 61  years, range 38-84  years; 21 (60  %) @entity1 were @entity1 . The @entity5 was located in the head of pancreas in 24 (69  %) @entity1 . The most common metastatic site was liver in 20 @entity1 with @entity3 (n   =   18, 90  %). The median follow-up time was 24.0  weeks (range 1.0-191.0  weeks). At the end of the observation period, 12 (34  %) @entity1 experienced disease progression and 23 @entity1 (66  %) were dead. Forty-four percent of 18 metastatic @entity1 who received palliative chemotherapy (CTx) were CTx-responsive. Median progression-free survival and overall survival of the whole group were 13.7        2.3  weeks [95  % confidence interval (CI)   =   9-18  weeks] and 48.0        12.8  weeks (95  % CI   =   23-73  weeks), respectively. The baseline serum @entity4155 levels were significantly higher in @entity1 with @entity788 than in the control group (p   =   0.001). Moreover, serum @entity4155 levels were significantly higher in the @entity1 with large pathologic @entity5 status and low albumin levels (p   =   0.04 and p   =   0.03, respectively). However, serum @entity4155 assays had no prognostic roles on outcome. CONCLUSION: Although serum levels of @entity4155 assays were found to be diagnostic value, no predictive and prognostic value was determined in @entity788 @entity1 .
