Reorganization in cognitive networks with progression of XXXX : insights from fMRI.

@entity1 @entity73 @entity3780 @entity23 @entity19383 @entity15 @entity922
OBJECTIVES: @entity73 ( @entity73 ) is frequent in @entity15 ( @entity15 ) and can occur at early stages. Whereas functional reorganization with disease progression has been described for the motor system in @entity15 using fMRI, no such studies exist for cognition. We attempted to assess the concept of functional reorganization concerning cognition using a simple "Go/No-go" fMRI paradigm. METHODS: @entity1 with a @entity922 ( @entity922 , n = 10), @entity3780 ( @entity3780 ) (n = 10), or @entity19383 ( @entity19383 ) (n = 10), and 28 @entity23 ( @entity23 ), underwent a comprehensive neuropsychological test battery, clinical examination, structural imaging, and an fMRI Go/No-go discrimination task at 3 T. RESULTS: @entity1 performed worse than @entity23 regarding memory, sustained attention and concentration, and information processing. These differences were driven by @entity1 with @entity19383 . The fMRI task elicited activation in a widespread network including bilateral mesial and dorsolateral frontal, parietal, insular, basal ganglia, and cerebellar regions. Task performance was similar between phenotypes, but deviation from the activation pattern observed in @entity23 and @entity1 with @entity922 increased with disease progression. @entity1 with @entity3780 showed increased brain activation in the precuneus, both superior parietal lobes, and the right fusiform gyrus, and recruited the hippocampus with increasing demands. @entity1 with @entity19383 demonstrated the most abnormal network function, including recruitment of pre-SMA, bilateral superior and inferior parietal, dorsolateral prefrontal, right precentral, bilateral postcentral, and right temporal brain areas. CONCLUSION: Using a cognitive fMRI paradigm, we were able to confirm adaptive changes of neuronal activation with progressing @entity15 and to provide strong evidence for their compensatory nature, at least partially.
