Leukocytosis of exercise: role of cardiac output and XXXX .

@entity1169 @entity1425 @entity2661 @entity1063 @entity1168
The effect of @entity1169 (5 mg iv) on the leukocytosis of exercise was studied in seven normal young males. Leukocyte counts, plasma @entity1063 (NE), @entity1425 (E), and cardiac output were measured at rest and in the steady state of several submaximal work loads when subjects exercised on a cycle ergometer. The results in control experiments were compared with those obtained on a different day with @entity1169 . @entity1169 @entity1168 at all work loads (P less than 0.001) but had no effect on the increase in cardiac output at increasing work loads. Plasma NE and E levels were similar at rest and in exercise in control and @entity1169 studies. There was no effect of @entity1169 on the increase in leukocyte counts with increasing work loads. Although @entity1169 did not affect the increase in total leukocyte count, the increase in lymphocyte count at higher work loads was less with @entity1169 . We conclude that the demargination of leukocytes from the pulmonary circulation in exercise is probably a mechanical effect of the increase in cardiac output. However, we have not excluded a contribution from a humoral event that would decrease the adherence of leukocytes to endothelium during exercise. The smaller increase in lymphocytes at higher work loads in the presence of @entity1169 suggests that @entity2661 affect the lymphocyte count over and above their effect on cardiac output.
