Comparative study of cytology and immunocytochemistry with trucut biopsy and immunohistochemistry in diagnosis of XXXX : A prospective study.

@entity1 @entity4153 @entity2940 @entity5 @entity957 @entity4206 @entity2 @entity358 @entity5822 @entity420 @entity7457
BACKGROUND: Percutaneous lung biopsy is now a common procedure in pulmonary medicine, and several different techniques are in use. The most common has been the use of a fine needle under computed tomography (CT) guidance combined with the trucut needle for histology. AIM: To evaluate the efficacy of fine needle aspiration cytology (FNAC) and immunocytochemistry in comparison with trucut biopsy and immunohistochemistry in @entity1 with localized intrathoracic lesions suspicious for @entity5 . MATERIALS AND METHODS: Eighty @entity1 with localized mass lesions in the lung on imaging (chest radiograph/CT) were selected for this study over a period of 1 year. FNAC was carried out by a 22 G spinal needle after localization of the mass in the CT scan followed by guided trucut biopsy. Immunocytochemistry and immunohistochemistry were performed as and when required. RESULTS: The mean age of our study population was 57.6 years and the M:F ratio was 4.2:1. Majority of the lesions were peripheral and in the right lung. @entity420 was most prevalent (49%), followed by @entity957 and @entity4153 . Cyto-histopathological concordance was seen in 60 cases (75%). The highest rate of concordance was seen in @entity4153 (83.3%). The overall sensitivity of FNAC in distinguishing @entity358 from benign lesions was 84.2% and the specificity was 100%. The sensitivity of cytology in diagnosing @entity4153 was 83.3% and of @entity4153 was 65.38%. Immunocytochemistry was carried out in 34 cases, all of which were followed by immunohistochemistry. Cyto-histopathological concordance was noted in 31 of these cases (91.2%). We used the standard panel of four markers ( @entity5822 , @entity7457 , @entity4206 and @entity2940 ) for all selected cases. CONCLUSION: Cytology along with immunocytochemistry is highly effective in diagnosing and categorizing @entity2 , producing comparable results to trucut biopsy and immunohistochemistry.
