Complication-Effectiveness Analysis for Unruptured XXXX Surgery: A Prospective Cohort Study.

@entity397 @entity1 @entity439 @entity438
BACKGROUND: The aim of intervention for unruptured @entity438 (UIAs) is safe, effective treatment. OBJECTIVE: To analyze a prospective database for variables influencing the risk of surgery to produce a risk model adjusting this risk for effectively treated @entity439 . METHODS: First, we identified variables to create a model from multiple logistic regression for complications of surgery leading to a 12-month modified Rankin Scale score >1. Second, we established the long-term cumulative incidence of freedom from retreatment or @entity397 (treated @entity439 ) from Kaplan-Meier analysis. Third, we combined these analyses to establish a model of risk of surgery per effective treatment. RESULTS: One thousand twelve @entity1 with 1440 UIA underwent 1080 craniotomies. We found that 10.1% (95% confidence interval [CI], 8.4-12.0) of craniotomies resulted in a complication leading to a modified Rankin Scale score >1 at 12 months. Logistic regression found age (odds ratio, 1.04; 95% CI, 1.02-1.06), size (odds ratio, 1.12; 95% CI, 1.09-1.15), and posterior circulation location (odds ratio, 2.95; 95% CI, 1.82-4.78) to be significant. Cumulative 10-year risk of retreatment or @entity397 was 3.0% (95% CI, 1.3-7.0). The complication-effectiveness model was derived by dividing the complication risk by the 10-year cumulative freedom from retreatment or @entity397 proportion. Risk per effective treatment ranged from 1% for a 5-mm anterior circulation UIA in a 20-year-old @entity1 to 70% for a giant posterior circulation UIA in a 70-year-old @entity1 . CONCLUSION: Complication-effectiveness analyses increase the information available with regard to outcome for the management of UIAs. ABBREVIATIONS: CE, complication-effectivenessCI, confidence intervalCTA, computed tomographic angiographyDSA, digital subtraction angiographyISUIA, International Study of Unruptured Intracranial AneurysmsMRA, magnetic resonance angiographymRS, modified Rankin ScaleUIA, unruptured @entity438 .
