The responses of adrenocorticotrophic hormone and @entity701 to XXXX -induced hypoglycaemic stress in @entity1 are unimpaired during chronic converting enzyme inhibition.

@entity1 @entity1369 @entity101 @entity2178 @entity2690 @entity3371 @entity701 @entity972 @entity916 @entity413
In vitro and animal studies indicate that circulating @entity2178 ( @entity2178 ) can stimulate adrenocorticotrophic hormone (ACTH) and @entity701 secretion, but it is far from established that @entity2178 has a physiologically relevant influence on steroidogenesis. We studied the effects of hypoglycaemia induced with @entity2690 injection (0.15 IU/kg) in @entity1 with essential @entity101 to answer this question. Hypoglycaemia was induced before and after a short term course of treatment with the converting enzyme inhibitor @entity3371 to obtain a sustained blockade of @entity2178 formation. Alterations in serum @entity413 , plasma @entity972 , plasma ACTH, @entity701 , @entity916 activity and @entity1369 were examined. In control studies there was a profound fall in serum @entity413 and plasma @entity972 after @entity2690 , associated with increments in plasma @entity916 activity, which correlated with those of @entity1369 but not with those of ACTH and @entity701 . Chronic @entity3371 increased baseline plasma @entity916 activity and lowered baseline @entity1369 while leaving ACTH and @entity701 unchanged. During converting enzyme inhibition the @entity2690 -induced decrements in @entity413 and @entity972 , as well as the increments in ACTH, @entity701 and @entity1369 , were similar to those observed in control studies, whereas the increments in plasma @entity916 activity were much greater. From these results it does not appear that @entity2178 has a relevant influence on ACTH and @entity701 production, or on their responses to hypoglycaemic stress. Rather, these findings indicate that even under the present experimental conditions @entity2178 is the primary regulator of @entity1369 secretion. However, this function can be taken over by ACTH when the generation of @entity2178 is blocked.
