Canine XXXX : a morphologic description of the natural disease.

@entity296 @entity712 @entity39 @entity944 @entity4 @entity358 @entity204 @entity2401
Naturally occurring acute @entity2401 in puppies 3 to 8 weeks of age was characterised clinically by @entity944 or @entity204 following a brief period of dyspnoea. Mortality within litters varied from 20% to 100%. The principal lesion was in the myocardium, which in most cases was mottled by pale patches and bands. Moderate to severe @entity4 with marked peribronchial and perivascular @entity4 was present. In some cases, the wall of the gall bladder was oedematous. Microscopically the ventricular myocardium had myofibre loss, multifocal myofibre @entity39 , a mononuclear cell infiltrate of variable intensity and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, intranuclear inclusion bodies in myocardial nuclei. Ultrastructurally the inclusions were composed of dense granular material and particles resembling parvovirions. @entity358 were thickened by fibroblasts. Peribronchial and perivascular lymphatics were distended with @entity4 fluid and occasionally erythrocytes. The @entity358 were considered secondary to the @entity296 . Some of the puppies that survived the acute disease developed @entity296 and died in @entity712 .
