[Serum concentration of soluble XXXX ( @entity4725 ) and expression of its receptor VLA-4 on the surface of peripheral blood and decidual lymphocytes of preeclamptic @entity1 ].

@entity1 @entity644 @entity2627 @entity26 @entity1468 @entity4725 @entity5690
INTRODUCTION: @entity4725 ( @entity4725 ) overexpression on the cells' surface is stimulated by pro-inflammatory cytokines, bacterial endotoxins, reactive @entity26 species and lipid @entity2627 . In the serum also the soluble form of @entity4725 (sVCAM-1) is present. The beta 1-integrin family molecule VLA-4 ( @entity5690 ) is natural ligand for @entity4725 . Increased concentrations of sVCAM-1 as well as overexpression of VLA-4 were observed during inflammatory reaction. THE AIM: To study sVCAM-1 serum concentrations and @entity5690 + subpopulations of peripheral blood and decidual lymphocytes of the 3rd trimester healthy and preeclamptic @entity1 . MATERIALS AND METHODS: The study groups: n = 21 healthy pregnant @entity1 , n = 33 preeclamptic @entity1 ( @entity1468 defined as blood pressure > 140/90 mmHg with @entity644 > 0.3 g/24 h). Clinical states of known pathogenesis which could possibly interfere with values of studied parameters were excluded. Exclusion criteria were also uterine contractions and premature rupture of amniotic membranes. Decidua was collected exclusively during elective caesarean sections. The sVCAM-1 concentration (ng/ml) was estimated using ELISA procedure, while percentage (%) of @entity5690 + lymphocytes in the whole blood and homogenized decidual tissue, using flow cytometry. The results were presented as median value with 25% and 75% cut off values. Statistical analysis was performed with U-Mann-Whitney test (p < 0.05). RESULTS: Preeclamptic @entity1 presented with increased sVCAM-1 serum concentrations (532.5 (400.0/605.0) ng/ml vs. 387.0 (320.0/416.5) ng/ml, p < 0.0005), increased (%) of @entity5690 + peripheral blood (92.0 (88.0/96.0)% vs. 52.9 (47.5/55.8)%, p < 0.0000001) and @entity5690 + decidual lymphocytes (88.0 (84.0/90.0)% vs. 80.5 (74.0/85.6)%, p < 0.05). CONCLUSION: Described change suggest that immunological mechanisms similar to inflammatory reaction could be involved in pathogenesis of @entity1468 in peripheral blood as well as locally inside maternal-fetal interface.
