[Involvement of serotoninergic mechanisms in the circling behaviour induced by XXXX and @entity10105 in @entity35 (author's transl)].

@entity935 @entity3826 @entity750 @entity35 @entity10105
Studies with selective lesions of cerebral structures have revealed the involvement of @entity750 in sleep and wakefulness. However, the mechanisms underlying the role of @entity750 remain obscure. An appreciation of the interrelationships between @entity750 and other transmitter systems might lead to a better understanding of the functions subserved by @entity750 . A serotoninergic projection from the median raph   nucleus to @entity935 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity935 pathway in the @entity35 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3826 administration to @entity35 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity10105 to the median raph   nucleus of normal @entity35 also provokes contralateral turning. On the other hand, unilateral injection of @entity10105 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3826 or @entity10105 was applied systematically, suggest that @entity750 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.
