@entity5402 promotes gastrointestinal function during oral resuscitation of XXXX .

@entity235 @entity1457 @entity3158 @entity5402 @entity413 @entity130
AIM: To investigate the effect of @entity5402 on gastrointestinal function in a @entity235 model of oral resuscitation for @entity1457 . METHODS: Twenty @entity235 with intubation of the carotid artery, jugular vein and jejunum for 24 h were subjected to 35% total body surface area full-thickness burns, and were divided into three groups: no fluid resuscitation (NR, n = 10), in which animals did not receive fluid by any means in the first 24 h post-burn; oral fluid resuscitation (OR, n = 8), in which @entity235 were gavaged with @entity413 -electrolyte solution (GES) with volume and rate consistent with the Parkland formula; and oral fluid with @entity5402 group (OR/CAR, n = 8), in which @entity235 were gavaged with GES containing @entity5402 (20  g/kg), with the same volume and rate as the OR group. Twenty-four hours after burns, all animals were given intravenous fluid replacement, and 72 h after injury, they received nutritional support. Hemodynamic and gastrointestinal parameters were measured serially with animals in conscious and cooperative state. RESULTS: The mean arterial pressure, cardiac output and plasma volume dropped markedly, and gastrointestinal tissue perfusion was reduced obviously after the @entity130 in all the three groups. Hemodynamic parameters and gastrointestinal tissue perfusion in the OR and OR/CAR groups were promoted to pre-injury level at 48 and 72 h, respectively, while hemodynamic parameters in the NR group did not return to pre-injury level till 72 h, and gastrointestinal tissue perfusion remained lower than pre-injury level until 120 h post-burn. @entity3158 of the gastric mucosa and intestinal mucosa blood flow of OR/CAR groups were 56.4    4.7 mmHg and 157.7    17.7 blood perfusion units (BPU) at 24 h post-burn, respectively, which were significantly superior to those in the OR group (65.8    5.8 mmHg and 127.7    11.9 BPU, respectively, all P < 0.05). Gastric emptying and intestinal absorption rates of GES were significantly reduced to the lowest level (52.8% and 23.7% of pre-injury levels) in the OR group at about 2 and 4 h post-burn, and did not return to 80% of pre-injury level until 24 h. In the first 24 h post-burn, the rate of gastric emptying and intestinal water absorption were elevated by a mean 15.7% and 11.5%, respectively, in the OR/CAR group compared with the OR group. At 5 days, the mortality in the NR group was 30% (3/10), 12.5% in the OR group (1/8), and none in the OR/CAR group. CONCLUSION: @entity5402 had a beneficial effect on oral resuscitation of @entity1457 by promoting gastric emptying and intestinal absorption in our @entity235 model.
