Dynamics of serum immunoglobulin G avidity for @entity2523 in XXXX .

@entity1 @entity7278 @entity21677 @entity2523 @entity36978
The purpose of this study was to examine avidity of immunoglobulin G (IgG) antibody for surface antigens of @entity2523 in sera from @entity1 with @entity7278 . The antigens used were whole cell antigens, lipopolysaccharides (LPS), and fimbriae of non-invasive @entity36978 and invasive 16-1. Serum IgG titers for the P. gingivalis antigens were measured by enzyme-linked immunosorbent assay (ELISA) before and after periodontal initial preparation. IgG avidity was measured by @entity21677 dissociation ELISA. IgG titers for the whole cell antigens of 16-1, LPS, and the fimbria antigens from both @entity2523 strains were significantly higher in the @entity1 group than those in the control group, whereas values for avidities were significantly lower in @entity1 sera. Although we found a statistically significant decrease in the IgG titers of @entity1 following initial preparation, avidities against the fimbria antigen of invasive 16-1 strain increased. The present study showed that IgG antibodies elicited in @entity1 were different in their ability to respond to invasive @entity2523 16-1 and to non-invasive 33277. The @entity1 sera with high IgG titers demonstrated low values for avidity, suggesting that IgG responses in @entity1 play a limited role in colonization inhibition or elimination of @entity2523 . The data indicate that periodontally healthy individuals may have highly functional antibodies which may protect against @entity2523 colonization. Our findings suggest that the ability to produce functional antibodies in the @entity1 group is lower than that in the periodontally healthy group, but the functional antibodies can be induced by the initial preparation.
