The association between the XXXX and peripheral, but not coronary, artery disease is partly mediated by @entity409 : the CODAM study.

@entity1 @entity32 @entity650 @entity3657 @entity6 @entity2104 @entity409 @entity4105 @entity71129 @entity209 @entity453 @entity2071 @entity65 @entity1851
BACKGROUND: The @entity209 is associated with @entity453 ( @entity453 ) and with @entity3657 ( @entity3657 ), but the underlying mechanisms explaining these associations have not yet been completely clarified. The aim was to investigate (i) whether @entity409 can explain the association between the @entity209 and @entity453 and/or the severity of @entity3657 , as measured by the ankle-arm index (AAIx); and (ii) whether any such mediation is independent of that from low-grade @entity32 . MATERIALS AND METHODS: We studied 539 subjects (232 @entity1 ) aged 59  4    6  9 years, with an increased risk of type 2 @entity6 and @entity65 . @entity409 and @entity32 scores were calculated from three markers of @entity409 (soluble @entity4105 , soluble @entity71129 ) and six of @entity32 ( @entity1851 , @entity650 , soluble @entity2071 , serum amyloid A, ceruloplasmin and @entity2104 ). The association between the @entity209 and @entity453 and/or @entity3657 , and the mediating role of @entity409 herein was examined with logistic and linear regression analyses, all adjusted for age, sex and smoking. RESULTS: Subjects with the @entity209 (n = 289; 54%) had higher prevalence of @entity453 [OR (95%CI) = 1  75 (1  14; 2  69)] and lower AAIx [b (95% CI) = -0  036 (-0  056; -0  016)]. @entity409 explained 6% of the association between the @entity209 and @entity453 , and 19% of the association with AAIx, whereas low-grade @entity32 explained 26% and 28% of these associations, respectively. Together, the two scores explained 24% and 36% of the association between the @entity209 and @entity453 and AAIx, respectively. CONCLUSIONS: @entity409 explains part of the association between the @entity209 and the severity of @entity3657 , but is not involved in the association between the @entity209 and @entity453 . This indicates that the pathophysiologies of coronary and @entity3657 are essentially distinct.
