Association Between XXXX .

@entity1 @entity1757 @entity3036 @entity1468 @entity299 @entity4297
Importance: The risk of @entity4297 in @entity1 of @entity1 who had @entity1468 during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions. Objective: To determine the prevalence of @entity4297 in offspring of @entity1 with @entity1468 . Design, Setting, and @entity1 : Population-level analysis of live births before discharge, 1989-2012, was conducted for the entire province of Quebec, comprising a quarter of Canada's population. All @entity1 who delivered an @entity1 with or without @entity299 in any Quebec hospital were included (N   =   1   942   072 neonates). Exposures: @entity1468 or @entity3036 with onset before or after 34 weeks of gestation. Main Outcomes and Measures: Presence of any critical or noncritical @entity4297 detected in @entity1 at birth, comparing prevalence in those exposed and not exposed to @entity1468 . Results: The absolute prevalence of @entity4297 was higher for @entity1 of @entity1 with @entity1468 (16.7 per 1000 [1219/72   782]) than without it (8.6 per 1000 [16   077/1   869   290]; prevalence ratio [PR], 1.57; 95% CI, 1.48 to 1.67). @entity1 of preeclamptic @entity1 had no increased prevalence of critical @entity299 (123.7 vs 75.6 per 100   000 [90/72   782 vs 1414/1   869   290]; PR, 1.25; 95% CI, 1.00 to 1.57; prevalence difference [PD], 23.6 per 100   000; 95% CI, -1.0 to 48.2) but did have an increased prevalence of noncritical @entity299 (1538.8 vs 789.2 per 100   000 [1120/72   782 vs 14   752/1   869   290]; PR, 1.56; 95% CI, 1.47 to 1.67; PD, 521.1 per 100   000; 95% CI, 431.1 to 611.0) compared with @entity1 of nonpreeclamptic @entity1 . Among specific defects, prevalence was greatest for @entity1757 . When stratified by variant of @entity1468 , @entity1 of @entity1 with early onset (<34 weeks) @entity1468 had greater prevalence of critical @entity299 (364.4 per 100   000 [20/5488]; PR, 2.78; 95% CI, 1.71-4.50; PD, 249.6 per 100   000; 95% CI, 89.7-409.6) and noncritical @entity299 (7306.9 per 100   000 [401/5488]; PR, 5.55; 95% CI, 4.98-6.19; PD, 6089.2 per 100   000; 95% CI, 5350.0-6828.3), whereas @entity1 of @entity1 with late onset (>= 34 weeks) did not. Conclusions and Relevance: In this population-based study, @entity1468 was significantly associated with noncritical @entity299 in offspring, and @entity1468 before 34 weeks was associated with critical @entity299 . However, the absolute risk of @entity4297 was low.
