@entity1735 intake and glycemic index affect substrate oxidation during a controlled weight cycle in healthy XXXX .

@entity1 @entity413 @entity435 @entity1735
BACKGROUND/OBJECTIVES: Because both, glycemic index (GI) and @entity1735 content of the diet increase insulin levels and could thus impair fat oxidation, we hypothesized that refeeding a low GI, moderate- @entity1735 diet facilitates weight maintenance. SUBJECTS/METHODS: Healthy @entity1 (n=32, age 26.0  3.9 years; BMI 23.4  2.0   kg/m(2)) followed 1 week of controlled overfeeding, 3 weeks of caloric restriction and 2 weeks of hypercaloric refeeding (+50, -50 and +50% energy requirement) with low vs high GI (41 vs 74) and moderate vs high @entity435 intake (50% vs 65% energy). We measured adaptation of fasting macronutrient oxidation and the capacity to supress fat oxidation during an oral @entity413 tolerance test. Changes in fat mass were measured by quantitative magnetic resonance. RESULTS: During overfeeding, @entity1 gained 1.9  1.2   kg body weight, followed by a weight loss of -6.3  0.6   kg and weight regain of 2.8  1.0   kg. Subjects with 65% @entity435 gained more body weight compared with 50% @entity435 diet (P<0.05) particularly with HGI meals (P<0.01). Refeeding a high-GI diet led to an impaired basal fat oxidation when compared with a low-GI diet (P<0.02), especially at 65% @entity435 intake. Postprandial metabolic flexibility was unaffected by refeeding at 50% @entity435 but clearly impaired by 65% @entity435 diet (P<0.05). Impairment in fasting fat oxidation was associated with regain in fat mass (r=0.43, P<0.05) and body weight (r=0.35; P=0.051). CONCLUSIONS: Both higher GI and higher @entity1735 content affect substrate oxidation and thus the regain in body weight in healthy @entity1 . These results argue in favor of a lower glycemic load diet for weight maintenance after weight loss.
