The effect of intraurethral XXXX on healing and @entity82 in @entity35 with experimentally induced @entity130 .

@entity32 @entity82 @entity22785 @entity35 @entity130
OBJECTIVE: To determine the efficacy of @entity22785 applied early after @entity130 for preventing @entity32 and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven @entity35 were randomized and divided into 3 groups, with 9 @entity35 in each group. The urethras of all @entity35 were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14  days, group I was given 0.9% saline twice a day (control group), group II was given @entity22785 500  mg/kg ampules once a day and 0.9% saline once a day, and group III was given @entity22785 500  mg/kg ampules twice a day intraurethrally using a 22  ga catheter sheath. On day 15, the penises of the @entity35 were degloved to perform penectomy. RESULTS: The mean @entity82 scores were 2.4, 2.2, and 1.4, and mean @entity32 scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for @entity32 (P  = .011); however, the difference for @entity82 was not significant (P  = .331). The differences between groups I and III were statistically significantly different both for @entity32 and @entity82 (P  = .004 and P  = .003, respectively). Groups II and III were not different significantly for @entity32 (P  = .638); however, there was less @entity82 in group III, in which high-dose @entity22785 was administered. CONCLUSION: We showed that @entity22785 applied early after @entity130 significantly decreased @entity32 and spongiofibrosis. We hope that our study will help to decrease strictures after @entity130 and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.
