Multimodal imaging does not delay intravenous thrombolytic therapy in XXXX .

@entity1 @entity10921 @entity64 @entity548 @entity385
BACKGROUND AND PURPOSE: @entity1 with acute @entity385 require immediate medical treatment, and a CT to rule out @entity548 is required before tPA. We adapted our protocol to include multimodal CT: unenhanced CT, CTA, and @entity10921 . The purpose of this study was to determine whether multimodal CT imaging delays initiation of IV tPA beyond 60 minutes from hospital arrival. MATERIALS AND METHODS: All @entity1 admitted during 3 years through the ED with a @entity64 alert and time from symptom onset to hospital arrival <2.5 hours were included. We examined 2 subgroups (multimodal CT versus unenhanced CT) to determine whether multimodal CT delayed tPA administration. Logistic regression was used to identify variables that predicted tPA within 60 minutes. RESULTS: There were 123 @entity1 in the analysis, including 108 @entity1 who were examined with multimodal CT. The median time from arrival to tPA was 56 minutes and was shorter for @entity1 examined with multimodal CT (55 versus 78 minutes, P = .02). After adjustment, variables that were associated with tPA administration within 60 minutes included prehospital @entity64 alert (OR = 3.47, P = .03), time to CT (OR = 0.94, P = .01), and onset-to-arrival time (OR = 1.02, P = .04). There was no statistically significant difference in the odds of receiving timely tPA for multimodal versus unenhanced CT (OR = 3.99, P = .07). CONCLUSIONS: In our single-center experience, the use of multimodal imaging in @entity1 with @entity64 did not delay IV tPA beyond 60 minutes. Further study is needed to assess the feasibility of the routine use of multimodal imaging in the @entity64 .
