Prognostic factors in XXXX of the salivary gland: correlation of immunohistochemical markers with histologic classification.

@entity1 @entity5 @entity5962 @entity406 @entity3909 @entity876 @entity3905 @entity3
@entity3905 of salivary glands is a rare @entity5 whose variable behavior and prognosis are related for the most part to the clinical stage and histologic grade of the @entity3909 component. The purpose of this study is to predict prognosis by comparing the histologic grading and subclassification of the @entity3909 component with the immunohistochemical reactivity for @entity5962 , @entity876 mutation protein, and cellular proliferation (Ki67). Stains were performed on @entity406 -fixed paraffin-embedded tissue sections from 18 cases of @entity3905 . Clinical follow-up was obtained for each @entity1 . Regional lymph node and distant organ metastases were the criteria for poor prognosis. Of seven cases with lymph nodes @entity3 , five were high-grade @entity5 (with one subsequent death from brain @entity3 ) and two were low-grade. Of the eight high-grade @entity5 , positivity for Ki67, @entity876 , and @entity5962 were noted in six, four, and two cases, respectively. In contrast, of the 10 low-grade @entity5 , two stained with Ki67, five with @entity876 , and none with @entity5962 . Most notably, all seven metastatic cases (as opposed to only one of 11 nonmetastatic @entity5 ) had Ki67 reactivity of more than 10%. We conclude that @entity3905 represents a spectrum of @entity5 in which the clinical behavior is closely related to the @entity3909 element. In addition to histologic grading, Ki67 is a useful prognostic marker in the evaluation of @entity3905 while @entity876 and @entity5962 appear to be of limited value.
