Sequential observation of liver cell regeneration after @entity11659 in XXXX transplantation.

@entity1 @entity82 @entity4166 @entity39 @entity409 @entity99 @entity11659
The morphogenesis of hepatocytes after @entity11659 to recovery through liver cell regeneration has not been fully understood. Sequential biopsies were performed on the native liver of a 22-year-old @entity1 who underwent @entity409 transplantation 1 month after fulminant @entity99 . Auxiliary partial orthotopic liver transplantation was successful, and the biopsy samples permitted us to examine the regenerating process of hepatocytes after massive @entity39 . At the time of @entity409 transplantation (postoperative day 0), 95% of hepatocytes were lost and a few ductules were found in the portal areas. The ductules stained with @entity4166 . At postoperative day 7, the ductules began to increase in size and number and became dilated over a period of 1 month, when individual hepatocytes with clear cytoplasm appeared from the ductules. As the differentiation of hepatocytes increased, the expression of @entity4166 was found to decrease. From 2 to 3 months, all of the ductules were transformed into hepatocytes, and they began to form round cell clusters. From 3 to 6 months, the round cell clusters became organized into trabecula with @entity82 . From 6 to 12 months, a lobular architecture was established, and by 14 months, the necrotic liver was fully recovered to normal. This study by examination of sequential biopsies demonstrates the progression of the regenerating process from total @entity99 to complete recovery.
