[Smoking and chronic XXXX ].

@entity1669 @entity1
INTRODUCTION: The chronic @entity1669 are heterogeneous entities by the functional, lesional and evolutive point of view. Ethiopathogenic factors involved in chronic @entity1669 are genetical factors, combines with environmental factors, hormonal factors, infectious factors etc. The exact role of smoking on the autoimmune mechanism is unclear, but smoking is known to have an antithyroid effect. AIM: Our study tries to estimate the influence of smoking on serum levels of antithyroid peroxidase antibodies and antithyroglobulin antibodies, in a group of @entity1 with various clinical forms of chronic @entity1669 . MATERIALS AND METHODS: We studied a group consists of 310 @entity1 with chronic @entity1669 , hospitalised in the Endocrinology Department of Constanta County Hospital, between January 2006 - December 2009. We detected serum values of antithyroidperoxidase antibodies and antithyroglobulin antibodies of our @entity1 . We also followed the age, sex and presence of smoking in our study group. For statistical processing of the data we use Student's t-test. RESULTS AND DISCUSSIONS: In our study group 24.28% of @entity1 were smokers. Serum levels of antithyroid peroxidase antibodies were significantly increased (p < 0.001) in the smokers @entity1 , compared with the nonsmokers patients. Serum levels of antithyroglobulin antibodies were significantly increased (p < 0.01) in smokers @entity1 , compared with those who were nonsmokers. CONCLUSIONS: Smoking increased the serum levels of antithyroid antibodies in @entity1 with chronic @entity1669 .
