Blood @entity112 is associated with @entity453 , cardiac events and severity of inflammation and XXXX .

@entity1 @entity1187 @entity731 @entity620 @entity10329 @entity112 @entity1856 @entity453 @entity9050
BACKGROUND: Mast cells are prevalent in the shoulder of unstable @entity1856 ; cardiac mast cells secrete proteases capable of activating matrix metalloproteinases. @entity112 is essential in the inflammatory cascade of the unstable plaque. @entity9050 depletion has been correlated with histaminemia which has been shown to impair endothelial-dependent vasodilation. This study evaluates whether oxidative stress as measured by @entity10329 (PGF(2alpha)) coupled with an inflammatory state characterized by histaminemia predisposes @entity1 to @entity1187 ( @entity1187 ). METHODS: Whole blood @entity112 , serum @entity620 , and serum PGF(2alpha) levels were drawn on 50 @entity1 with @entity1187 as determined by standard diagnostic criteria, 50 @entity1 with @entity453 ( @entity453 ), and 50 age and sex matched normal controls (C). RESULTS: Data were analyzed by stepwise discriminant and Spearman's rank correlation coefficient. A significant relationship exists between @entity112 and PGF(2alpha). As PGF(2alpha) rises above 60 pg/mL, an increase in @entity112 occurs in both the @entity1187 and @entity453 groups. A significant inverse relationship exists between @entity9050 and @entity112 in the @entity1187 versus C groups (P < 0.01) and the @entity453 versus C groups (P < 0.01). CONCLUSION: @entity112 and @entity10329 levels increase in @entity453 and @entity1187 @entity1 . Mast cell activation and lipid oxidation generated during @entity731 manifest this inflammatory response. Accelerated @entity10329 formation and depleted @entity9050 paired with histaminemia is active in CAD and predispose @entity1 to @entity1187 . Blood @entity112 alone may be a better risk factor for coronary events, and a better prognostic indicator than CRP even when combined with lipid indexes.
