Cerebral blood flow and tissue metabolism in experimental @entity2806 of spontaneously XXXX @entity35 with hyper-, normo-, and @entity4053 .

@entity4372 @entity3884 @entity101 @entity2806 @entity63 @entity4053 @entity855 @entity880 @entity35 @entity4854 @entity413 @entity2388
The present study was designed to clarify the effect of blood @entity413 level on cerebral blood flow and metabolism during and after @entity2806 induced by bilateral carotid ligation (BCL) in spontaneously @entity101 @entity35 (SHR). Blood @entity413 levels were varied by intraperitoneal infusion of 50% of @entity413 ( @entity4854 ), insulin with @entity4372 saline ( @entity4053 ) or @entity4372 saline (normoglycemia). Cerebral blood flow (CBF) in the parietal cortex and thalamus was measured by @entity3884 clearance technique, and the supratentorial metabolites of the brain frozen in situ were determined by the enzymatic method. In non- @entity63 animals, blood @entity413 levels had no influence on the supratentorial @entity880 , @entity2388 or @entity855 ( @entity855 ) concentrations. In @entity63 animals, however, cortical CBF was reduced to less than 1% of the resting value at 3 hours after BCL. However, there were no substantial differences of CBF during and after @entity63 among 3 glycemic groups. Cerebral lactate in the @entity63 brain greatly increased in @entity4854 (34.97 +/- 1.29 mmol/kg), moderately in normoglycemia (23.43 +/- 3.13 mmol/kg) and less in @entity4053 (7.20 +/- 1.54 mmol/kg). In contrast, cerebral @entity855 decreased in @entity4854 (0.93 +/- 0.19 mmol/kg) as much as it did in normoglycemia (1.04 +/- 0.25 mmol/kg), while @entity855 reduction was much greater in @entity4053 (0.45 +/- 0.05 mmol/kg). At 1-hour recirculation after 3-hour @entity63 , @entity855 tended to increase in all groups of animals, indicating the recovery of energy metabolism. Such metabolic recovery after recirculation was good in hypo- and normoglycemia, and was also evident in @entity4854 . Our results suggest that @entity4854 is not necessarily an unfavorable condition in acute incomplete @entity2806 .
