Clinical impact of pregnancy in XXXX : a study of the Spanish Network on @entity5310 (REMA) in 45 cases.

@entity1 @entity20145 @entity5310 @entity649 @entity262 @entity272
BACKGROUND: The impact of pregnancy on mast cell (MC)-related symptoms and newborn outcome in @entity1 with @entity5310 is not well described. We report a series of 30 @entity1 who had 45 pregnancies. METHODS: @entity1 completed a specific questionnaire concerning MC mediator release symptoms graded according to their frequency to detect clinical changes occurring during pregestation and pregnancy as well as postpartum. Information about the medications received during pregnancy and labor and about newborn medical complications was also recorded. RESULTS: Worsening of MC-related symptoms during pregnancy was observed in 10 cases (22%); additionally, 1 @entity1 developed @entity272 as a manifestation of @entity262 ( @entity262 ) within the third trimester of pregnancy. Conversely, 15 cases (33%) experienced clinical improvement during pregnancy, with a complete resolution of pregestational symptoms in 7 cases. MC mediator release symptoms intrapartum were observed in 5 cases (11%) without any fatal outcome. Newborn medical complications (e.g. prematurity, low birth weight, and @entity649 ) were detected in 7 @entity1 (16%) who were all successfully managed with conservative measures. One @entity1 developed @entity20145 several years after birth. CONCLUSIONS: @entity5310 has a heterogeneous clinical behavior during pregnancy: the profile of MC-related symptoms remained unchanged in half of the cases, while in the other half pregnant @entity1 experienced either an improvement or an exacerbation of the symptoms, with the manifestation of @entity262 during pregnancy in 1 case. To prevent potential life-threatening MC-related symptoms, adequate prophylactic antimediator therapy intrapartum should be systematically administered. The absence of both maternal and @entity1 severe complications suggests that @entity1 with nonaggressive categories of @entity5310 should not be advised against pregnancy.
