@entity16340 response to a meal before and after cutting the extrinsic nerves of the stomach in the XXXX .

@entity235 @entity16340 @entity3897
@entity3897 inhibits the post-prandial @entity16340 release after truncal vagotomy in the @entity235 . Whether this action of @entity3897 is due to suppression of stimulatory cholinergic fibres in the sympathetic nerves of the stomach and the upper small intestine or due to blockade of intrinsic gastric cholinergic mechanisms is unknown. Conscious @entity235 were fed a meat meal (35 g/kg body weight) before and after truncal vagotomy and after truncal vagotomy plus coeliac and superior mesenteric ganglionectomy. Experiments were repeated in the presence of @entity3897 (50 micrograms/kg body weight, given as an i.v. bolus 60 min prior to the meal). In another set of @entity235 , only ganglionectomy was performed and the same experiments were done as in the first set of @entity235 . Truncal vagotomy enhanced the post-prandial 120 min integrated plasma @entity16340 response by 2.6 times as compared to the response with the vagus nerves intact. Before truncal vagotomy, @entity3897 enhanced the integrated plasma @entity16340 response by 2.6 times; after truncal vagotomy @entity3897 suppressed this response by 2.3 times. After truncal vagotomy, with or without @entity3897 , additional coeliac and superior mesenteric ganglionectomy did not alter the integrated plasma @entity16340 response. With the vagus nerves intact, ganglionectomy alone had no effect on the integrated plasma @entity16340 response whether or not @entity3897 was given. The finding that @entity3897 suppresses the post-prandial plasma @entity16340 response to a meal after truncal vagotomy and coeliac and superior mesenteric ganglionectomy, i.e. cutting the extrinsic nerves of the stomach and the upper small intestine, suggests the existence of stimulatory cholinergic intrinsic fibres located within the stomach.
