Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined XXXX : Consecutive survivors and population-based controls.

@entity1 @entity64 @entity301 @entity41263 @entity887 @entity41264 @entity432 @entity731 @entity385
OBJECTIVE: Due to contradictory results of previous studies evaluating the association between @entity385 ( @entity385 ) and thrombophilic polymorphisms, their routine screening in @entity385 @entity1 , particularly those older than 60 years, is not recommended. We evaluated the differences in the distribution of @entity41263 and @entity41264 polymorphisms according to @entity385 subtypes and their interaction with smoking. METHODS: We conducted a case-control study of 423 hospital-based consecutive survivors of their first-ever @entity385 and 614 population-based controls. Survivors (18-81 years) with @entity385 documented by brain imagining were examined at a median of 16 months after the index event. The @entity64 subtype was categorized using the Causative Classification of @entity64 System. Controls (50-75 years) were free of a history of @entity64 /TIA, @entity301 . RESULTS: Age- and gender-adjusted prevalence of individuals carrying at least one copy of the rs1799963A minor allele was 5.3% among @entity64 survivors (by subtypes: 3.1% in large artery @entity731 , 2.0% in @entity887 , 2.4% in small @entity432 , and 10.3% in undetermined @entity64 ) vs. 2.4% among controls. In multinomial multivariate adjusted analysis, @entity41264 was exclusively associated with undetermined @entity64 (OR: 3.67; 95% CI: 1.52-8.85; p  =  0.004). There was strong evidence of @entity41264  *  smoking synergistic interaction (OR: 5.14; 95% CI: 1.65-16.01; p  =  0.005). There was no association of @entity41263 with @entity385 in general, or with any subtype. CONCLUSIONS: In our consecutive @entity385 survivors, carriage of the rs1799963A allele is associated with undetermined @entity64 . This effect appears to be confined to smokers.
