Immunohistochemical evaluation of a XXXX with osteoclastlike giant cells.

@entity1 @entity96 @entity5 @entity409 @entity1419 @entity157
BACKGROUND: Malignant @entity96 with osteoclast-like giant cells are rare. A literature search showed 17 previously reported cases that included the following: (1) 8 undifferentiated @entity157 , (2) 5 @entity5 with osteoclast-like giant cells associated with @entity1419 or @entity409 , and (3) 4 @entity5 with osteoclast-like giant cells associated with areas of a @entity157 . CASE PRESENTATION: A 68-year-old @entity1 presented with a @entity5 of the right lobe of the liver on ultrasonography and computed tomography. Laparoscopy showed a @entity5 (diameter, 4  cm) in segments 7 and 8 of the right liver lobe that adhered to the retroperitoneum. The @entity5 recurred 3  months after liver segmentectomy. Repeat laparoscopy showed diffuse and nodular metastases to the omentum and peritoneum. RESULT: Light microscopy showed that part of the @entity5 had features of classic @entity157 . Another part of the @entity5 had a solid sarcomatous pattern with osteoclast-like giant cells that were irregularly distributed between the smaller undifferentiated @entity5 cells; cells of this part of the @entity5 were positive for heppar-1. CONCLUSION: Light microscopic findings including osteoclast-like giant cells, and the strong reaction of heppar-1 antibody with cells of the sarcomatous part of the @entity5 , confirmed that this sarcomatous element was a metaplastic or transformed portion of @entity157 . VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6000512901462616.
