Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in @entity1 with XXXX .

@entity1 @entity6688 @entity497
OBJECTIVE: This study aims to investigate whether mean platelet volume ( @entity6688 ) is correlated with the CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, >65 years of age) score, and whether a combination of the CURB-65 score with @entity6688 could better predict the 28-day mortality in @entity1 with @entity497 ( @entity497 ). METHODS: This prospective, observational, single-center, and cross-sectional study was conducted at emergency department (ED) between September 1, 2013, and July 31, 2014. All @entity1 underwent follow-up evaluations 28 days after admission. The end point was defined as all-cause mortality. RESULTS: A total of 174 @entity1 (mean age, 66.7    15.8 years; 66.1% @entity1 ) with @entity497 were enrolled in this study. All-cause mortality at the 28-day follow-up evaluation was 16.1%. A significant and inverse correlation between @entity6688 and CURB-65 score was found (R = -.58, P < .001). We determined that the optimal @entity6688 cutoff for predicting 28-day mortality at the time of ED admission was 8.55 fL, with a 75.0% sensitivity and a 75.3% specificity. For the prediction of 28-day mortality, the area under the receiver operating characteristic curve was 0.819 (95% confidence interval [CI], 0.740-0.898; P < .001) when the CURB-65 score was used alone, whereas it increased to 0.895 (95% CI, 0.819-0.936; P < .001) with the addition of @entity6688 to the score. CONCLUSIONS: Mean platelet volume level is valuable for predicting mortality and the severity of disease among @entity1 with @entity497 at ED admission. Furthermore, a combination of CURB-65 score and @entity6688 can enhance the predictive accuracy of 28-day mortality.
