Toxoplasmic XXXX --clinical and serologic profile.

@entity1 @entity1395 @entity281 @entity3252 @entity3298
OBJECTIVE: To study the serologic profile of several types of test for @entity3252 , in order to contribute to the interpretation of antibody kinetics. METHODS: The clinical and serologic features of 120 cases of lymphadenopathy with known time of clinical onset were studied during 18 months postinfection. Antibody kinetics was determined by Sabin-Feldman dye test, complement fixation with light antigen, IgM immunofluorescent antibody test, and IgM immunosorbent agglutination assay (IgM-ISAGA). Cell-mediated immunity was evaluated by the toxoplasmin skin test. RESULTS: Seventy-five female @entity1 aged 11-54 years (median 27 years) and 45 male @entity1 aged 3-59 years (median 17 years) were studied, 85% of whom were under 30 years of age. Cervical lymph nodes were involved throughout, generally on both sides, with more than one affected ganglion group in 88%. The predominant symptom was @entity1395 (69%), which persisted in some cases for several months. A negative Sabin-Feldman dye test in a lymphadenopathy with more than three weeks' evolution excludes a toxoplasma etiology. A positive Sabin-Feldman dye test with negative IgM-ISAGA almost invariably excludes @entity281 . The Sabin-Feldman dye test was positive in 94% of @entity1 with titers higher than 1 : 16 000 within the first three months. The IgM-ISAGA yielded 98% of positive results, of which 94% were high titers. Titers >/= 1 : 160 in the IgM immunofluorescent antibody test and complement fixation were found to be highly indicative of @entity281 , since 87% and 91%, respectively, were found within the first three months. A negative skin test plus positive serology values indicates @entity281 . CONCLUSION: Our results indicate that estimation of time of @entity281 on the basis of serologic results is improved by the simultaneous application of several tests, and correlates closely with the presence of clinical @entity3298 .
