Evaluation of the hormonal function and histological features of heterotopic isogenic ovarian transplantation in XXXX .

@entity43 @entity254 @entity53 @entity2670 @entity35
The purpose of the study was to determine the feasibility of preserving ovarian function after heterotopic transplantation by means of microvascular @entity254 of the transplanted vascular pedicles to a set of preselected vessels. Six groups of 10 Sprague-Dawley inbred @entity35 were used in this study. Group I underwent bilateral ovariectomy operation and served as the ovariectomy control. Group II underwent bilateral ovariectomy followed by @entity43 . Group III underwent bilateral ovariectomy and isogenic heterotopic ovarian transplantation by means of microvascular @entity254 . Group IV served as the laparotomy sham-operated control. Group V served as the ovarian donor for group II. Group VI served as the donor of the @entity2670 pedicle complex for group III. Postoperative ovarian @entity53 levels were measured, and histological characteristics were elucidated in groups I, II, III, and IV. The results demonstrated that the @entity53 level of the transplantation group was comparable to that of the sham operation group and was significantly higher than that of the implantation group. Histologically normal ovarian architecture was observed in the sham group (IV) and also in the transplantation group (III). Altered architecture was observed in the implantation group (II). These findings indicate that extraabdominal heterotopic ovarian transplantation with microvascular @entity254 led to normal ovarian hormonal function and was effective in preserving oocyte production capacity.
