Enzyme induction and serum and lipoprotein lipids: a study of XXXX in normal subjects.

@entity1674 @entity46229 @entity412 @entity41379 @entity165
1. Serum and lipoprotein @entity165 and @entity1674 were measured before, during and after the administration of @entity46229 (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in @entity41379 excretion and antipyrine clearance. 3. Concentrations of total serum @entity165 , very-low-density-lipoprotein-, low-density-lipoprotein and high-density-lipoprotein- @entity165 rose significantly during treatment. 4. The time course of these changes was delayed in comparison with the rise and fall in @entity41379 excretion. 5. There was no change in the @entity412 content of either whole serum or lipoprotein fractions at any time during the trial. 6. The study provides further evidence that enzyme-inducing agents cause a rise in certain lipid concentrations.
