[Electrophysiologic effects of intravenous XXXX ].

@entity1 @entity3798 @entity8942 @entity591 @entity956 @entity70987 @entity955 @entity943
The electrophysiological properties of @entity70987 a new Class I antiarrhythmic agent (Delalande Research Centre) were studied after intravenous injection of 3.5 mg/kg in 5 minutes in 16 @entity1 aged 24 to 66 years. Five minutes after the injection there was a significant increase (p less than 0.01) in the HV (+/- 12.8 +/- 10.5 msec), @entity3798 (+ 21.8 +/- 14 msec) and PR intervals (+ 43.8 +/- 24.2 msec) and in the duration of QRS (+ 20.6 +/- 9.9 msec). The anterograde and retrograde Wenckebach points were decreased (-42 +/- 43 bpm and - 52 +/- 36 bpm respectively, p less than 0.05). All these effects reverted progressively 20 minutes after injection and disappeared by the 40th minute, which corresponds to the pharmaco-kinetic profile of the @entity1 . There were no changes in blood pressure, sinus node function or refractory periods except for the retrograde refractory periods which were prolonged (+ 87 +/- 41 msec). @entity955 was induced in 2 @entity1 and @entity956 in 2 others by the extrastimulus technique. These @entity943 could not be reproduced in these 4 @entity1 during the 40 minutes after injection of @entity70987 . Five other @entity1 with reciprocating @entity591 induced by atrial extrastimuli had their @entity943 interrupted by the @entity70987 injection. We conclude that @entity70987 acts mainly on atrio-ventricular and intra-ventricular conduction. The results obtained in @entity1 with @entity591 suggest that the product is effective in @entity943 and @entity8942 .
