Cone biopsy and pathologic findings at radical hysterectomy in XXXX .

@entity5 @entity1 @entity1350
OBJECTIVE: To examine the association between cone biopsy and pathologic findings at radical hysterectomy in @entity5 . METHODS: Fifty-four @entity1 diagnosed by cone biopsy with @entity5 and treated with radical hysterectomy comprised the study group. The association between the depth of invasion on conization, @entity1350 , positive cone margins, positive endocervical curettage (ECC), and the depth of residual invasion in the radical hysterectomy specimen was examined using Pearson r and point biserial correlation. Independent predictors of the depth of residual invasion were determined by multiple regression. RESULTS: The depth of residual invasion correlated significantly with the depth of invasion (r =.374) and presence of @entity1350 (r(pb)=.372) in the conization specimen, post-cone ECC status (r(pb) =.669), and age at diagnosis (r =.347). The same factors were jointly assessed using multiple regression (R(2) =.636, P<.001). Depth of invasion on conization, @entity1350 , and ECC status were identified as independent predictors of the depth of residual invasion. @entity1 with deep (5 mm or greater) stromal invasion and @entity1350 on conization had significantly higher rates of positive parametrial margins (22% compared with zero, P =.001) and adjuvant radiation (66.7% compared with 20%, P =.004) compared with all other @entity1 . CONCLUSION: Depth of invasion, presence of @entity1350 , and age at diagnosis were independent predictors of the depth of residual invasion in the subsequent hysterectomy specimen. These factors should be considered in treatment planning. @entity1 with a combination of these factors may have increased risk for deep residual invasion, positive hysterectomy margins, and adjuvant radiation.
