XXXX nanotubes and nanoplatelets as reinforcing agents of polymeric matrices for bone tissue engineering.

@entity8240 @entity852 @entity137 @entity49474 @entity19 @entity71921 @entity2848
UNASSIGNED: This study investigates the mechanical properties and in vitro @entity137 of one- and two-dimensional @entity8240 nanomaterials-reinforced biodegradable polymeric nanocomposites. @entity49474 ( @entity2848 ) nanocomposites were fabricated using crosslinking agent @entity71921 and inorganic nanomaterials: @entity8240 nanotubes (BNNTs) and @entity8240 nanoplatelets (BNNPs) dispersed at 0.2 wt % in the polymeric matrix. The incorporation of BNNPs and BNNTs resulted in a    38 and    15% increase in compressive (Young's) modulus, and    31 and    6% increase in compressive yield strength compared to @entity2848 control, respectively. The nanocomposites showed a time-dependent increased protein adsorption for collagen I protein. The @entity137 evaluation of aqueous BNNT and BNNP dispersions (at 1-100  g/mL concentrations) using @entity19 MC3T3 preosteoblast cells showed    73-99% viability. The @entity137 evaluation of media extracts of nanocomposites before crosslinking, after crosslinking, and upon degradation (using 1*-100* dilutions) showed dose-dependent @entity137 responses. Crosslinked nanocomposites showed excellent (   79-100%) cell viability, cellular attachment (   57-67%), and spreading similar to cells grown on the surface of tissue culture @entity852 control. The media extracts of degradation products showed a dose-dependent @entity137 . The favorable cytocompatibility results in combination with improved mechanical properties of BNNT and BNNP nanocomposites opens new avenues for further in vitro and in vivo safety and efficacy studies towards bone tissue engineering applications.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.
