Immunoglobulin G1 (IgG1) and @entity3172 antibodies are markers of progressive disease in XXXX .

@entity1 @entity1203 @entity3172 @entity4430 @entity4544 @entity1201
@entity4430 -specific and polyclonal immunoglobulin G (IgG) subclass and IgE antibodies in @entity1201 @entity1 across the histopathological spectrum were determined by using a quantitative enzyme-linked immunosorbent assay. Antibody responses to @entity4430 sonicates were detected only in IgG1, -2, and -3 subclasses. Even at 100-times-lower dilutions, very little IgG4 and IgE antibody activity against @entity4430 was detected in any group of @entity1201 @entity1 . Quantitatively, antibody responses were highest at the lepromatous pole and decreased towards the tuberculoid pole. The greatest quantitative difference in antibodies between the lepromatous and tuberculoid poles was observed with IgG1 (140-fold), this was followed by the difference with @entity3172 antibodies (32-fold). Polyclonal antibodies, on the other hand, were elevated for all four IgG subclasses as well as IgE in both @entity4544 @entity1 compared with healthy controls from a @entity1201 . Selective elevation of M. leprae-specific antibody responses in IgG1 and @entity3172 subclasses, therefore, could not be attributed to selective polyclonal activation in these particular subclasses. Furthermore, polyclonal activation for IgE was observed in both @entity4544 @entity1 , with higher levels in the tuberculoid group, which does not support selective TH2 activation in @entity1203 patients. IgG1 and @entity3172 antibodies also showed the highest Spearman rank correlation with the bacterial index in these @entity1 (rho = 0.748 and P < 0.001 for IgG1; rho = 0.721 and and P < 0.001 for @entity3172 ). Thus, disease progression in @entity1201 showed a significant correlation with selective increases in IgG1 and @entity3172 responses.
