Long-Term Analysis of Ab-2 (Clone SN3b) Immunoreactivity as a Prognostic Factor in XXXX .

@entity1 @entity0 @entity5 @entity189 @entity11707 @entity1735
BACKGROUND: @entity11707 expression has been described as a significant prognostic factor in multiple solid @entity5 . Most of these studies have, however, been undertaken using the Ab-2 antibody (clone SN3b), which detects a @entity11707 -associated @entity1735 , and not the @entity11707 protein itself. Although its biological identity remains unclear, its prognostic significance means that detection of this @entity1735 may, nonetheless, be clinically relevant. METHODS: 133 @entity0 were selected (pT1-2 pN0-2 M0, no secondary @entity189 , no @entity189 ) from a previous SN3b expression study on a larger cohort of @entity0 . After updating data on follow-up observations, we carried out univariate and multivariate analysis of the prognostic significance of SN3b for total and @entity0 -specific survival. RESULTS: A statistically significant correlation between cytoplasmic SN3b immunoreactivity and positive node status was found. Cytoplasmic SN3b also has node status-independent prognostic significance. Total survival exhibits a statistically significant dependency on cytoplasmic SN3b even for pN0 cases. CONCLUSION: The independent prognostic value of @entity11707 as detected by Ab-2/clone SN3b could replace the diagnostic axillary dissection in @entity0 @entity1 if this was confirmed in further studies. Also, clarifying the exact epitope of this interesting antibody is more than warranted.
