Severity of XXXX as a risk factor for ileo-anal anastomotic leak after a pouch procedure in @entity31 .

@entity530 @entity1 @entity32 @entity31
PURPOSE: The @entity530 ( @entity530 ) carries significant post-operative complication risks including a 4-14  % risk of ileo-anal anastomotic (IAA) leak [1-4]. The aim of this study is to evaluate the severity of disease at the distal resection margin as an independent risk factor for an IAA leak following the @entity530 for @entity1 with @entity31 ( @entity31 ). METHODS: A retrospective matched case-control study was undertaken. The distal margin of each subject's specimen was reviewed by a blinded pathologist and the degree of @entity32 was scored using a modified histological activity index (mHAI)-a 0 to 5 graded scale with HAI of 5 representing ulcerations >25  % the depth of bowel wall. RESULTS: Forty-nine @entity1 with perioperative IAA leaks (mean 11  days   0.92) were identified and matched for gender, age and year of surgery. The case cohort had 33 males (67  %) of mean age at time of surgery of 36.3  years (  1.42). The severity of @entity32 did not increase the risk of IAA leak. The presence of a diverting ileostomy was associated with a decreased incidence of an IAA leak (p   =   0.01). CONCLUSION: Studies with greater power will be required to evaluate the association (if any) between histological severity of @entity31 at the distal margin of a @entity530 procedure and IAA leak rate. This risk factor could influence preoperative management and post-operative outcome in @entity1 requiring the @entity530 .
