Expression of growth factors and structural proteins in XXXX : basic fibroblast growth factor, @entity310 , and fibronectin are correlated with recurrence.

@entity1 @entity7 @entity310 @entity5 @entity3580
OBJECTIVE: To test the hypothesis that the expression of certain growth factors and/or structural proteins is correlated with the biological behavior of cranial base @entity3580 . METHODS: The study investigated 14 pathological specimens of cranial base @entity3580 from @entity1 who were monitored for at least 2 years after their initial operations. Some cases involved @entity5 recurrences and multiple operations. For those @entity1 , the time to recurrence after each operation was recorded and a mean value was calculated. Nine @entity1 with mean times to recurrence of 24 months or more or with 24 months of follow-up monitoring without recurrence after single operations were designated the "good-prognosis" group. Five @entity1 with mean times to recurrence of less than 24 months were designated the "poor-prognosis" group. In each case, only the specimen from the initial operation was studied. Multiple sequential sections were cut from paraffin-embedded blocks of tissue and immunohistochemically prepared for detection of three growth factors and three structural proteins, i.e., basic fibroblast growth factor, @entity310 , @entity7 , fibronectin, collagen III, and collagen IV. Intensity of expression was graded by using a four-tier system (Grades 0, 1, 2, and 3). Levels of expression of the molecules in the two groups were evaluated and compared. RESULTS: The mean @entity310 expression intensity grades for the good- and poor-prognosis groups were 0.8 and 2.6, respectively, and the corresponding mean basic fibroblast growth factor grades were 1.4 and 2.6. For both groups, the mean grade for @entity7 expression was 0.6. For fibronectin, the mean staining grades for the good- and poor-prognosis groups were 2.2 and 3.0, respectively. The corresponding mean intensities for collagen III were 1.1 and 0.8, and those for collagen IV were 2.5 and 2.6. CONCLUSION: Our descriptive data from immunohistochemical analyses of @entity3580 suggest that high levels of @entity310 and basic fibroblast growth factor expression are linked to higher rates of recurrence. Strong fibronectin expression may also be a marker of aggressive biological behavior.
