XXXX , @entity2690 Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging: @entity731 Risk in Communities Study.

@entity1 @entity66 @entity28 @entity2690 @entity1144 @entity209 @entity731
BACKGROUND AND PURPOSE: The term @entity209 describes the clustering of risk factors found in many individuals with @entity28 . Because of their pathophysiology, we hypothesized that 2 features of @entity209 , @entity1144 and @entity2690 resistance (IR), would be associated with cerebrovascular changes on magnetic resonance imaging, and specifically with incident @entity66 and not white matter hyperintensity (WMH) progression. METHODS: Risk factors were defined at study baseline in 934 @entity1 in the @entity731 Risk in Communities (ARIC) study, who completed 2 brain magnetic resonance imagings   10 years apart. WMH progression and incident lacunes between the 2 magnetic resonance imagings were determined. An IR score for each @entity1 was created using principal component analysis of 11 risk factors, including (among others): @entity2690 , homeostatic model assessment-IR, body mass index, and waist circumference. @entity209 (presence/absence), using standard clinical definitions, and IR score at the first magnetic resonance imaging, were independent variables, evaluated in multivariate logistic regression to determine odds of WMH progression (Q5 versus Q1-Q4) and incident lacunes. RESULTS: @entity209 (adjusted odds ratio, 1.98; 95% confidence interval, 1.28-3.05) and IR score (adjusted odds ratio per 1-SD increase, 1.33; 95% confidence interval, 1.05-1.68) were associated with incident lacunes but not with WMH progression. @entity2690 , homeostatic model assessment-IR, and body mass index were not associated with incident lacunes or WMH progression in separate models. CONCLUSIONS: The IR score and @entity1144 are associated with incident @entity66 but not WMH progression in individuals. @entity1144 and IR may be important risk factors to target to prevent @entity66 .
