Effects of XXXX and @entity1443 on postoperative sleep.

@entity37656 @entity1 @entity28999 @entity30061 @entity158 @entity1443
The separate and combined effects of @entity37656 (25 mg) and @entity1443 (1 gm) on sleep were studied by interview procedures and information from medical records of 2,931 postoperative @entity1 . The sample contained 1,617 @entity1 with mild or moderate @entity158 and 1,314 who were free of @entity158 . Each received either @entity28999 alone (S), @entity1443 alone (A), a combination of both drugs (C), or placebo (P). Drug treatment was double blind and randomized separately for the @entity158 and @entity158 -free subsamples. Twelve measures of sleep were determined. C was more beneficial than S or A, and S and A were each superior to P. For all 12 sleep measures, the effect of the combination (C - P) approximated or exceeded the sum of the two separate effects ( @entity30061 ). The presence of either drug tended to enhance the sleep benefit of the other. The sedative and analgesic benefits to sleep were at least additive, and some outcome measures suggested synergism. In the total sample, the contributions of sedative and analgesic similar. Among @entity1 with @entity158 , contributions of the analgesic surpassed those of the sedative. For @entity1 free of @entity158 , the sedative was better, but even @entity158 -free @entity1 had enhanced sleep after the analgesic. The analgesic, but not the sedative, reduced @entity158 ; the analgesic induced the feeling of being well rested and not tired; the sedative induced a feeling of being drugged. Nondrug variables (e.g., @entity158 , sex, age, and sleep expectations) influenced sleep outcome at least as much as drugs, but randomization and the large sample prevented those extraneous variables from biasing drug comparisons.
