@entity102 with @entity480 : elevated serum immunoglobulin E is associated with XXXX on culture.

@entity1 @entity480 @entity794 @entity102
BACKGROUND: Recent data has implicated @entity794 (SA) superantigen as a potential disease modifier in @entity1 with @entity102 ( @entity102 ) with @entity480 (CRSwNP). The objective of this work was to compare total serum immunoglobulin E (IgE) and serum eosinophils in @entity1 with CRSwNP and @entity102 without @entity480 (CRSsNP) based on culture results of the 3 most commonly isolated bacteria. METHODS: Retrospective review at a tertiary rhinology referral center of @entity1 with @entity102 over a 4-year period. RESULTS: Bacterial cultures and immunologic data were obtained from 62 @entity1 with CRSwNP and 34 @entity1 with CRSsNP. SA was the most prevalent bacteria in the CRSwNP group, isolated in 19 @entity1 (31%). @entity1 with elevated total serum IgE (>114 IU/mL) were more likely to have SA on culture (p = 0.04) in this population. The percent serum eosinophil levels in the SA+ group compared with the SA- group was not significant (6.0 vs 5.1, p = 0.17). Lund-Mackay computed tomography (CT) scores, but not Sino-Nasal Outcome Test 20 (SNOT-20) scores were significantly higher in the SA+ vs SA- group (p = 0.03) in @entity1 with CRSwNP. The CRSsNP group demonstrated no difference in IgE or serum eosinophils between different bacterial groups. CONCLUSION: Our findings suggest that there is an association between SA sinonasal presence and elevated total serum IgE in @entity1 with CRSwNP. In addition, SA+ @entity1 had higher Lund-Mackay CT scores, indicating a higher objective burden of disease in this group of @entity1 .
