Metabolic risks identified by the combination of enlarged waist and elevated XXXX concentration.

@entity1 @entity6 @entity2299 @entity5710 @entity1674 @entity755 @entity3190 @entity5052 @entity209 @entity4854 @entity413 @entity165 @entity414
BACKGROUND: Abdominal fat and circulating @entity1674 increase with age, which indicates lipid overaccumulation. Enlarged waist (EW) with elevated @entity1674 (ET) could identify adults at metabolic risk. OBJECTIVE: Using thresholds for EW and ET observed among the youngest adults, we estimated for all adults the prevalence of combined EW and ET (EWET) and described the metabolic risks associated with EWET. DESIGN: In a cross-sectional, weighted sample of 9183 adults, we used two-dimensional displays to provide thresholds for EW ( @entity1 : > or = 95 cm; @entity1 : > or = 88 cm) and fasting ET (> or = 1.45 mmol/L) and estimated the characteristics of EWET among adults of all ages. RESULTS: The population prevalence of EWET in 18-24-y-olds was 6%; it rose with age until age 55-74 y (prevalence: 43%) and then was lower among the elderly. @entity1 with EWET were more likely (P < 0.0001) to have adverse mean (+/- SEE) concentrations of risk variables in adjusted analyses (fasting insulin: 43 +/- 3 pmol/L; HDL @entity165 : -0.27 +/- 0.02 mmol/L; @entity755 : 0.20 +/- 0.01 g/L; fasting @entity413 : 0.71 +/- 0.07 mmol/L; @entity414 : 50 +/- 2 micromol/L) and to have @entity6 (relative risk: 3.2) than were @entity1 without EWET. Compared with a similar-size subpopulation with high body mass index, @entity1 with EWET were older and had more @entity2299 , @entity4854 , and @entity5052 . Compared with " @entity209 ," EWET identified more @entity1 who were younger and had greater LDL- @entity165 and @entity755 concentrations. Compared with " @entity5710 ," EWET identified more @entity1 with @entity3190 , @entity2299 , and @entity5052 . CONCLUSIONS: EWET identifies a syndrome of lipid overaccumulation associated with metabolic risk and accelerated mortality after middle age. Prospective studies should evaluate this simple indicator.
