Malnutrition Predicts Clinical Outcome in XXXX with @entity5 .

@entity5 @entity1 @entity74 @entity3147
UNASSIGNED: Malnutrition is a common problem in oncologic diseases influencing treatment outcomes, treatment complications, quality of life and survival. The potential role of @entity3147 has not yet systematically been studied in neuroendocrine @entity5 (NEN), which due to growing prevalence and additional therapeutic options provide an increasing clinical challenge for diagnosis and management. The aim of this cross-sectional observational study, which included a long-term follow-up, was therefore to define the prevalence of @entity3147 in 203 @entity1 with NEN using various methodological approaches and to analyze the short- and long-term outcome of malnourished @entity1 . A detailed subgroup analysis was also performed to define risk factors for poorer outcome. By applying @entity3147 screening scores 21-25% of NEN- @entity1 were at risk of or demonstrated manifest @entity3147 . This was confirmed by anthropometric measurements, determination of serum surrogate parameters such as albumin and bioelectrical impedance analysis particularly phase angle a. Length of hospital stay (LoS) was significantly longer in malnourished NEN- @entity1 while long-term overall survival was highly significantly reduced. @entity1 with high-grade (G3) neuroendocrine carcinomas, @entity74 and undergoing chemotherapy were at particular risk for @entity3147 associated with a poorer outcome. Multivariate analysis confirmed the important and highly significant role of @entity3147 as an independent prognostic factor for NEN besides proliferative capacity (G3-NEC). Malnutrition is therefore an underrecognized problem in NEN- @entity1 , which should systematically be diagnosed by widely available standard methods such Nutritional Risk Screening (NRS) score, serum albumin levels and bioelectrical impedance analysis (BIA) and treated to improve both short- and long-term outcomes.
