[Influence of inhaled XXXX on the induction doses of @entity1875 and thiopental assessed by auditory evoked potentials].

@entity1 @entity3727 @entity26 @entity4490 @entity1875 @entity3810
OBJECTIVES: To assess the influence of 50% @entity3810 ( @entity3727 ) on the induction doses of @entity1875 and @entity4490 by means of the auditory evoked potentials index (AAI). To evaluate the time to induction of anesthesia. @entity1 AND METHOD: This was a prospective controlled trial in ASA 1-2 @entity1 randomized to 4 groups for administration of @entity1875 in 100% @entity26 (group P1), @entity1875 in a mixture of 50% @entity3727 and 50% @entity26 (group P2), thiopental in 100% @entity26 (group T1) or thiopental in a 50% @entity3727 and 50% @entity26 mixture. An AAI monitor was used. Continuous intravenous infusions of 1% @entity1875 or 2.5% thiopental were administered at a rate of 120 mL h(-1) until an AAI of less than 40 (clinical hypnosis) and then an AAI of less than 20 (surgical hypnosis) were obtained. Vital signs, induction doses required to reach an AAI of 40 and of 20, and induction times were recorded. RESULTS: One hundred sixty @entity1 with a body mass index of less than 30 kg/m2 were enrolled. The biological parameters and vital signs were similar in the 4 groups of 40 @entity1 each. The induction doses of thiopental and @entity1875 and the induction times were significantly reduced in the groups in which the mixture of 50% @entity3727 and 50% @entity26 was used in comparison with the groups breathing 100% @entity26 , in terms of both AAI target values of 20 and 40 (P<.01). There were no complications in any @entity1 . CONCLUSIONS: The doses of both thiopental and @entity1875 are reduced and induction times are shorter when the drugs are administered with a mixture of 50% @entity3727 and 50% @entity26 . Monitoring the AAI facilitates the titration of thiopental and @entity1875 dosing during anesthetic induction.
