XXXX homeostasis disorder during and after neonatal extracorporeal membrane oxygenation.

@entity1 @entity2741 @entity326 @entity3873 @entity519 @entity460 @entity461 @entity1760
BACKGROUND AND AIMS: Extracorporeal membrane oxygenation (ECMO) is used during pediatric resuscitation in case of refractory @entity519 or @entity326 under maximum therapy. Previous studies describe @entity460 homeostasis dysregulation. The aim of this study was to confirmed of @entity460 homeostasis dysregulation in neonates under ECMO and supposed news explanation. SUBJECTS AND METHODS: From November 2012 to July 2013, we performed a prospective single center observational study. Eleven neonatal @entity1 were included. Blood was obtained before and during ECMO (day 7, 14 and 21) for @entity461 ( @entity461 ), protein adjusted serum @entity460 , ionized @entity460 , @entity1760 , and @entity3873 levels. All surviving @entity1 underwent a consultation up to 6 months after ECMO weaning. RESULTS: During ECMO @entity461 was inadequately high with normal serum @entity460 on day 7 ( @entity461 : 73.54    40 ng/l; calcemia: 2.33    0.21 mmol/l), day 14 ( @entity461 : 57.63    29.57 ng/l; calcemia: 2.44    0.43 mmol/l) and day 21 ( @entity461 : 54.93    8.43 ng/l; calcemia: 2.13    0.09 mmol/l). The absence of correlation between serum @entity460 and @entity461 levels seem to confirm the dysregulation of @entity461 - serum @entity460 metabolism during ECMO. Six months after ECMO weaning, we noticed @entity2741 with normal @entity461 . CONCLUSIONS: We confirmed the existence of severe disturbances of @entity460 homeostasis in neonates on ECMO and supposed the possible damage of @entity460 regulation. We did not succeed in finding clear explanations of these disturbances.
