Dietary salt restriction activates mineralocorticoid receptor signaling in volume-overloaded XXXX .

@entity712 @entity1369 @entity296 @entity1219 @entity292 @entity299 @entity35 @entity551 @entity1482
Whether a high plasma @entity1369 concentration induced by strict salt restriction promotes @entity299 remains controversial. Male @entity35 at 10weeks of age were given normal salt (NS) (1.5% @entity1219 ) or low salt (LS) (0.05% @entity1219 ) diets. Each animal underwent aortocaval @entity292 creation for volume-overloaded @entity712 or sham surgery. All @entity35 with a @entity292 received either vehicle or a non- @entity551 dose of @entity1482 (200mg/kg/day) by gavage. Two weeks later, the LS diet significantly increased the plasma @entity1369 level in the sham-operated and @entity292 -created @entity35 (2677+/-662pg/ml and 2406+/-422pg/ml) compared with that in @entity35 given the NS diet (518+/-18pg/ml and 362+/-45pg/ml, respectively). In sham-operated @entity35 , the difference in plasma @entity1369 level did not affect the extent of @entity296 (1.8+/-0.1% with LS diet vs. 1.5+/-0.3% with NS diet). However, the increase in @entity296 in @entity292 -created @entity35 was more prominent with the LS diet than with the NS diet (4.7+/-0.3% vs. 3.4+/-0.1%). In addition, the @entity292 -created @entity35 on the LS diet expressed significantly increased oxidative stress and transforming growth factor-beta compared with those on the NS diets (P<0.05). These increases in the @entity292 -created @entity35 on the LS diet were significantly suppressed by the non- @entity551 dose of @entity1482 (P<0.05). These results suggest that increased plasma @entity1369 level with strict salt restriction activated the mineralocorticoid receptor signaling in volume-overloaded condition, resulting in @entity296 .
