Abnormal mitochondrial cristae were experimentally generated by high doses of XXXX venom in the @entity35 adrenal cortex.

@entity137 @entity9624 @entity4968 @entity35 @entity5157
In the present study, @entity5157 venom ( @entity9624 ) was tested for its ability to cause ultrastructural changes in mitochondria of @entity35 adrenal cortex in vivo. In order to achieve this goal, different @entity9624 treatments were performed and the effects were quantified on transmission electron micrographs. In a first experimental group, @entity9624 injected for 30 days in low daily doses (700  g/kg) generated important ultrastructural changes in zona fasciculata. The mitochondrial ultrastructure was not affected, but the diameters of mitochondrial cristae (MC) were reduced (57.066    7.795 nm) as compared to the MC diameters in the corresponding control groups (58.596    6.603 nm, and 58.503    5.708 nm). In adrenal glands collected from @entity35 injected with a single, high dose of @entity9624 (62 mg/kg), many ultrastructural changes were described. Mitochondria with normal, tubular MC (with diameter of 58.711    5.907 nm) were observed in many cells, very close to the values calculated for the corresponding control group (58.639    6.117 nm). However, the striking data reported herein concerned the ability of @entity9624 high doses to promote dramatic alterations in the ultrastructure of these particular mitochondria, similar to those described in certain severe diseases. Thus, several types of abnormal mitochondria were observed, including mitochondria displaying lamellar and/or circular, concentric cristae and mitochondria devoid of cristae. The abnormal circular, concentric MC, with large inner (281.904    158.588 nm) and outer (432.076    230.372 nm) diameters, appeared to be the most stable form of MC in the adrenal cortex after the acute treatment with @entity9624 . Among other ultrastructural aspects, these important changes indicated a high level of @entity137 of @entity9624 in adrenocortical cells following in vivo experimental @entity4968 .
