[Evaluation of the antihypertensive effect of capsule and tablet forms of XXXX in moderate @entity101 ].

@entity1 @entity101 @entity3371 @entity460 @entity594 @entity551
The antihypertensive effect of @entity594 which has a preferential antagonistic action in the @entity460 channels of vascular smooth muscle was studied in several series of @entity1 . A preliminary double-blind placebo study in 7 moderate @entity101 @entity1 showed that a 10 mg capsule of @entity594 induced a significant @entity551 (max. - 14%) which persisted for 3 hours in ambulatory @entity1 . A crossover trial against @entity3371 (1 mg/kg) in 12 moderately @entity101 @entity1 illustrated the antihypertensive effects of 2 capsules (20 mg) of @entity594 . The onset of action was faster and the effects, which were more intense than those of @entity3371 , lasted several hours. A double-blind crossover trial against placebo was performed with 3 doses (20, 40, 60 mg) of a tablet form of @entity594 in 8 @entity101 @entity1 . The degree and duration of the fall in blood pressure depended on the dosage: - 11% and 7 hours with 20 mg; - 14% and 10 hours with 40 mg and - 18% and 12 hours with 60 mg. This study demonstrated a direct relationship between the plasma concentration of @entity594 and the associated fall in mean blood pressure. Finally, in a chronic study of 20 @entity101 @entity1 receiving 2 X 20 mg daily of the tablet form of @entity594 alone for 3 weeks, an 8% fall in blood pressure was observed, normalising the values in 50% of cases. @entity1 who remained @entity101 were given 2 X 40 mg of the @entity594 tablets for another 3 weeks and an additional 7% fall in blood pressure was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
