Prospective study of XXXX and adverse birth outcomes.

@entity1 @entity4736 @entity548 @entity63 @entity5028 @entity1468 @entity8455 @entity1054 @entity16071
OBJECTIVE: To investigate the association between @entity1054 ( @entity1054 ) and adverse birth outcomes. DESIGN: Prospective cohort study. SETTING: Not applicable. @entity1 (S): A total of 3,521 singletons born to @entity1 aged 18-40 years at cohort entry. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Selected birth outcomes, including preterm birth (PTB, <37 weeks' gestation), low birth weight (<2,500 g), small for gestational age, large for gestational age, and @entity5028 , ascertained from the Danish Medical Birth Registry and Danish National Registry of @entity1 . Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression, with adjustment for potential confounders and fertility treatment. RESULT(S): Multivariable RRs for PTB in relation to @entity1054 of 3-5, 6-11, and >= 12 vs. <3 cycles were 1.59 (95% CI 0.94-2.69), 0.85 (95% CI 0.48-1.50), and 1.57 (95% CI 0.93-2.65). The association was slightly stronger for spontaneous PTB ( @entity1054 >= 12 vs. <3 cycles: @entity4736 .69, 95% CI 0.84-3.42) than for medically indicated PTB ( @entity4736 .39, 95% CI 0.62-3.12). Longer TTPs (>= 12 cycles) were associated with increased risks of low birth weight ( @entity4736 .80, 95% CI 0.97-3.35), cesarean delivery ( @entity4736 .64, 95% CI 1.27-2.12), @entity5028 ( @entity16071 .21, 95% CI 1.07-4.56), @entity63 ( @entity4736 .56, 95% CI 0.99-2.44), @entity1468 ( @entity4736 .45, 95% CI 0.79-2.65), and postpartum @entity548 ( @entity4736 .58, CI 1.14-2.19), and decreased risks of @entity8455 (>= 4,500 g; RR 0.63, 95% CI 0.35-1.13) and large for gestational age (RR 0.76, 95% CI 0.58-1.00). Longer @entity1054 showed little association with small for gestational age. CONCLUSION(S): In a prospective cohort study of Danish pregnancy planners, delayed conception was a marker for adverse birth outcomes, after accounting for fertility treatment.
