Moderation of the association between childhood maltreatment and XXXX by the @entity20583 gene.

@entity20583 @entity31245 @entity1 @entity308 @entity31244 @entity148 @entity663 @entity31243
BACKGROUND: @entity663 is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially @entity308 and @entity148 . Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the @entity20583 gene has been found to moderate the association of childhood maltreatment with @entity308 , and we hypothesized that it would also be linked to @entity663 . METHODS: Variation in three @entity20583 SNPs ( @entity31244 , @entity31245 , @entity31243 ) was assessed in 339 maltreated and 275 demographically similar nonmaltreated @entity1 , who participated in a day camp research program. Maltreated @entity1 were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with @entity1 . RESULTS:     @entity20583 genotype significantly moderated the association of maltreatment with @entity663 but none of the other traits. Having two copies of the TAT haplotype of @entity20583 was associated with higher levels of @entity663 among maltreated @entity1 relative to nonmaltreated @entity1 , with the exception of sexually abused @entity1 and @entity1 who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from   2=.01 (p=.02) to   2=.03 (p=.006). CONCLUSIONS: Variation in @entity20583 moderates the association of maltreatment with @entity663 . The effects of specific types of maltreatment on @entity663 are differentially moderated by @entity20583 genotype, as are the effects of experiencing more or fewer types of maltreatment.
