Intracranial pressure changes during XXXX development.

@entity19 @entity14819 @entity5796 @entity428
UNASSIGNED: During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. @entity428 ( @entity428 ), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at the sutural edges of calvarial bones, especially shortly after birth when the brain is growing rapidly. The aim of this study was to quantify @entity428 during @entity19 development. A custom pressure monitoring system was developed and calibrated. It was then used to measure @entity428 in a total of seventy three wild type @entity19 at postnatal (P) day 3, 10, 20, 31 and 70. Retrospectively, the sample in each age group with the closest @entity428 to the average value was scanned using micro-computed tomography to estimate cranial growth. @entity428 increased from 1.33  0.87mmHg at P3 to 1.92  0.78mmHg at @entity14819 and 3.60  1.08mmHg at @entity5796 . In older animals, @entity428 plateaued at about 4mmHg. There were statistically significant differences between the @entity428 at the P3 vs. @entity5796 , and @entity14819 vs. @entity5796 . In the samples that were scanned, intracranial volume and skull length followed a similar pattern of increase up to @entity5796 and then plateaued at older ages. These data are consistent with the possibility of @entity428 being a contributing factor to bone formation at the sutures during early stages of development. The data can be further used for development and validation of computational models of skull growth.
