[Severe and acute XXXX admitted in intensive care: a prospective epidemiological multiple centre study using CClin network database].

@entity1 @entity788 @entity1212 @entity55 @entity281 @entity2259
OBJECTIVES: To describe the demographic characteristics, incidence of extra-abdominal hospital-acquired @entity281 and outcome of @entity1 admitted to intensive care unit (ICU) with severe acute @entity788 . STUDY DESIGN: A retrospective, observational multiple center (65 centers) analysis of prospectively acquired data. @entity1 AND METHODS: During 2 years, all consecutive admitted @entity1 to ICU for severe acute @entity788 in the centers participating in the nosocomial @entity281 surveillance network CClin Sud-Est were included. @entity1 whose ICU stay was less than 48 hours were not included. Demographic characteristics, extra-abdominal hospital-acquired @entity281 and clinical course were described. RESULTS: During the study period, 510 @entity1 were included which represented 2 % of @entity1 with a length of stay longer than 48 hours in the 65 participating ICUs. The global attack rate of extra-abdominal hospital-acquired @entity281 ( @entity55 , @entity2259 , urinary tract or central @entity1212 ) was 23 % in overall @entity1 and it was 33 % in the 294 mechanically ventilated @entity1 . ICU mortality was 20 % in overall @entity1 and it was 34 % in mechanically ventilated @entity1 . CONCLUSION: Severe acute @entity788 represents 2 % of ICU stay longer than 48 hours. Its clinical course is frequently complicated by hospital-acquired @entity281 and is associated with an high ICU mortality rate. This epidemiological observational study may be used for calculating sample size for future multicenter interventional therapeutic studies.
