@entity23150 and XXXX in @entity191 : a single-blind crossover study.

@entity1 @entity2847 @entity390 @entity304 @entity935 @entity191 @entity1833 @entity25 @entity23150
INTRODUCTION: Clinicians switch from one @entity935 agonist to another for various reasons. However, each change may inadvertently result in certain potential risks such as decreased medication efficacy or new side-effects. OBJECTIVE: We evaluated the tolerability of a switch of @entity2847 to @entity23150 using two conversion ratios as a primary outcome measure, with motor function as a secondary outcome measure, in @entity1 with mild to moderate @entity191 ( @entity191 ). METHODS: Twenty consecutive @entity1 with mild to moderate @entity191 (Hoehn and Yahr, stage II-III) on treatment with stable doses of @entity2847 and levodopa were randomized to two groups of 10 @entity1 each, to receive @entity23150 based on 1:5 or 1:10 conversion ratios. Blinded evaluations were performed: 1) @entity304 's Diseased Rating Scale (UPDRS) scores both in 'on' and 'off', 2) Open-ended interviews for adverse events, 3) Epworth Sleepiness Scale, 4) Purdue Pegboard assessment during 'on' and 'off', 5) Hand-arm movement test during 'on' and 'off', and 6) Walking test during 'on' and 'off'. RESULTS: Major adverse events included ' @entity25 ' in one @entity1 and minor side-effects included giddiness, @entity390 , @entity1833 , sleepiness and lethargy. However, these were mild and 19 (95%) of the 20 @entity1 completed the study. There was a significant improvement in both the UPDRS 'off' total and motor scores at 1 month compared with baseline for the group on 1:10 ratio. The walking times during the 'off' state at 1 and 2 months were significantly better compared with baseline in the 1:5 group. There were otherwise no significant differences in the rating tests during both 'off' and 'on' states before and after the @entity2847 switch. CONCLUSIONS: We demonstrated that @entity1 with mild to moderate @entity191 who were on relatively low doses of @entity2847 can be safely switched to @entity23150 based on a conversion ratio of either 1:5 or 1:10. However, the higher conversion ratio has to be carried out with caution in @entity1 with daytime somnolence.
