Minute flat depressed XXXX of the colon detected by contrast chromoscopy using an indigo carmine capsule.

@entity1 @entity1313 @entity189 @entity20696 @entity652
Thirty-seven diminutive flat depressed @entity1313 of the colon, smaller than 5 mm, were detected by contrast chromoscopy using an indigo carmine capsule and subsequently removed by endoscopic mucosal resection. We investigated the endoscopic, macroscopic, and histologic characteristics of these lesions and also evaluated the usefulness of chromoscopy and the magnifying endoscope for detecting this type of lesion. The lesions were classified into two types according to the measured height of the histologic sections: 28 lesions were truly flat depressed and the remaining 9 lesions were flat elevated. Of the 37 lesions, 18 were @entity652 with mild atypia, 14 with moderate atypia, and 5 with severe atypia. The flat depressed lesions included 12 with mild atypia, 11 with moderate atypia, and 5 with severe atypia. No @entity189 was present in either type, and no @entity652 with severe atypia was identified in any of the flat elevated lesions. The overall rate of severe atypia was 13.5%; the rate of severe atypia for the flat depressed type was 17.9%, which is approximately 14-fold greater than that of ordinary diminutive polypoid @entity652 (1.3%). The detection of these lesions was facilitated by the use of indigo @entity20696 dye, which clearly demonstrated the mucosal irregularities. The frequency of detection of these lesions was increased four to five times with a magnifying endoscope, as occurred in nearly 10% of all of the @entity1 examined. These data suggest that the finding of endoscopically minute flat depressed @entity1313 is not at all uncommon when examination is meticulously performed.(ABSTRACT TRUNCATED AT 250 WORDS)
