Sentinel node biopsy using @entity3194 in XXXX .

@entity1697 @entity5 @entity3194 @entity6693 @entity3
BACKGROUNDS: Radioactive tracer-based detection has been proposed as a standard procedure in identifying sentinel nodes for cN0 @entity1697 . However, access to radioactive isotopes may be limited in some surgical centers, and there is potential risk of the radioactive tracers to the operators. This study was designed to evaluate the feasibility of near-infrared fluorescence imaging with @entity3194 combined with blue dye mapping in sentinel node biopsy for cN0 @entity1697 . METHODS: Twenty-six cases of previously untreated @entity1697 staged cT1-2N0M0 were enrolled in this study. One milliliter of @entity3194 (5 mg/ml) and 1.5 ml of @entity6693 (1 mg/ml) were injected sequentially around the primary @entity5 in a four-quadrant pattern before skin incision. After elevation of the platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with a near-infrared detector, with special attention paid to any blue-dyed lymph nodes. Lymph nodes identified first with fluorescent hot spots with or without blue dye were defined as sentinel nodes, and they were harvested and sent for pathologic study. RESULTS: Sentinel nodes were successfully harvested in all 26 cases. The number of sentinel nodes (SNs) per case varied from 1 to 9, with an average of 3.4. Routine pathology demonstrated occult @entity3 exclusively in SNs in four cases (15.4 %). No tracer-associated side effects occurred in this series. CONCLUSIONS: Near-infrared imaging using @entity3194 combined with @entity6693 mapping is a feasible and reliable new method for SN biopsy in cN0 @entity1697 .
