Spectrum of acute hemodynamic effects of @entity594 in severe XXXX .

@entity1 @entity64 @entity712 @entity594 @entity453
The acute hemodynamic effects of 20 to 50 mg of orally administered @entity594 were evaluated in 31 @entity1 with severe chronic @entity712 ( @entity712 ) and the results were analyzed according to the response of the cardiac index (CI). Although the group mean value of CI increased significantly after @entity594 treatment (from 2.1 +/- 0.5 to 2.4 +/- 0.8 liters/min/m2, p less than 0.001), the individual response was variable. Twenty of the @entity1 had 15% or greater increase in CI (group A) and 11 @entity1 had less than a 15% increase or a decrease in CI (group B). Marked differences were also noted in the effects of @entity594 on other hemodynamic variables. @entity64 volume increased 29 +/- 14% in group A and decreased 11 +/- 18% in group B (p less than 0.001). Systemic vascular resistance decreased 34 +/- 11% in group A (p less than 0.001) and increased slightly, 2 +/- 28%, in group B. Left ventricular (LV) @entity64 work index increased 11 +/- 19% in group A (p less than 0.001) and decreased markedly in Group B (21 +/- 20%). Six group B @entity1 had a substantial worsening (20% or more) of one or more hemodynamic measurements, including CI, @entity64 volume index, @entity64 work index and mean pulmonary artery wedge pressure. A comparison of control hemodynamic values at rest, LV ejection fraction, associated @entity453 , @entity594 dose, and concomitant diuretic therapy revealed no significant differences between the 2 groups. This study confirms, in a large group of @entity1 with severe @entity712 , the variable hemodynamic effects of @entity594 therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
