[Optimum choice of antibiotic treatment in XXXX due to group B streptococci].

@entity801 @entity883 @entity114 @entity3401 @entity2348 @entity4509 @entity281 @entity581 @entity869
Morbidity and mortality among neonates with group B @entity883 remain high. As delays in @entity2348 may be responsible for these poor results, there is a need for studies into killing kinetics. We investigated antimicrobial sensitivity and killing effect time lags for @entity114 , @entity869 and @entity3401 , alone and in combination with @entity801 or @entity4509 , against 20 strains of group B streptococci isolated in cultures of blood and cerebrospinal fluid from neonates. A culture of each strain (10(5) germs/ml) was exposed to the antibiotics individually or in combination. Antibiotics were used in the concentrations achieved clinically. Surviving bacteria were counted after 2 h 30, 4 h 30 and 24 h. incubation. Mean killing curves showed that the time interval until onset of a killing effect was 24 hours with either @entity114 or @entity869 alone, against 4 h 30 with @entity114 - @entity4509 or @entity869 - @entity801 . The most rapid killing effect (2 h 30) was observed with @entity3401 alone and @entity869 - @entity4509 . No antagonism was found between @entity3401 and @entity581 . Choice of the best antibiotic treatment for group B @entity883 should be based on both the rapidity of the in vitro killing effect and the antibiotic's diffusion into the site of the @entity281 .
