Quantitative assessment of XXXX + lymphocytes and eosinophils for the histopathological differential diagnosis of @entity29 .

@entity1 @entity31 @entity29 @entity5823 @entity8787 @entity30
BACKGROUND AND AIMS: The histopathological discrimination of @entity30 [ @entity30 ] and @entity31 [ @entity31 ] can be challenging. The aim of this study was to evaluate if quantification of @entity5823 (+) lymphocytes and eosinophils in histopathological material improves the accuracy of diagnosis of @entity29 . METHODS: A total of 156 @entity1 were diagnosed with @entity8787 by a gastroenterologist and corroborated by 5 years of follow-up. @entity1 were treatment na  ve at the time of biopsy. Samples were taken from diseased areas of the colon and examined by a gastrointestinal pathologist. RESULTS: The median number of eosinophils in biopsies from affected segments was 42/high power field [hpf] [25.5-63.5] in @entity30 and 98/hpf [67-123] in @entity31 [p < 0.001]. Biopsies containing >=  70 eosinophils/hpf field had a sensitivity of 78.3% and a specificity of 71% for the diagnosis of @entity31 ({area under the receiver operating characteristic (ROC) curve 0.767 (95% confidence interval [CI] 0.696-0.838)}. There was a median of three @entity5823 (+) cells/hpf [range 2-6] in diseased @entity30 biopsies and 33 cells/hpf [24-52] in diseased @entity31 biopsies [p < 0.001]. The cut-off determined by the ROC curve was 15 (sensitivity 97.4%, specificity 97.4%, positive likelihood ratio (PLR) 17.1, Negative likelihood ratio (NLR) 0.03, area under the curve [AUC]: 0.978; 95% CI 0.95310.999). CONCLUSIONS: Routine histopathological assessment with quantification of @entity5823 + cells is highly accurate at discriminating @entity30 and @entity31 . All the measured parameters are easy to perform, low-cost, and available in most pathological laboratories.
