Value of Neutrophil-Lymphocyte Ratio in Predicting Outcomes in XXXX .

@entity1 @entity573 @entity439 @entity453 @entity574
UNASSIGNED: Total and differential leukocyte counts are useful inflammatory biomarkers. The ability of the neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in @entity1 with @entity573 ( @entity573 ) was assessed in this study. All @entity1 with @entity573 who underwent consecutive complete blood count analyses during the acute febrile phase before intravenous immunoglobulin (IVIG), 2  days after IVIG regardless of defervescence, and 3 to 4  weeks after defervescence were enrolled. NLR was calculated by dividing the neutrophil count by the lymphocyte count. NLR values that best predicted IVIG resistance and the development of @entity453 were determined by receiver-operating characteristic curve and multivariate analyses. Of the 587 @entity1 with @entity573 , 222 were IVIG resistant. IVIG-resistant @entity1 had higher NLRs than IVIG-responsive @entity1 . The best NLR cut-off values during the acute febrile phase and 2  days after IVIG for predicting IVIG resistance were 5.49 (p <0.001) and 1.26 (p <0.001), respectively. Sixty-two @entity1 developed @entity453 ; 47 had coronary dilatation, and 15 had @entity439 . @entity1 with @entity439 , but not @entity1 with dilatation, had higher NLRs than @entity1 without @entity453 . The best NLR cut-off value 2  days after IVIG for predicting @entity439 development was 1.01 (p  <0.001). Multivariate analysis revealed that the NLR 2  days after IVIG independently predicted @entity574 development (p  = 0.03) and IVIG resistance (p <0.001). In conclusion, the NLR can be used for risk stratification in @entity1 with @entity573 . An NLR 2  days after IVIG that exceeded 1 was predictive of @entity574 development and IVIG resistance.
