Prognostic and Biological Significance of MicroRNA-127 Expression in @entity1 XXXX .

@entity1 @entity0 @entity26605 @entity4042 @entity3
The purpose of this study was to determine the expression of @entity26605 and analyze its prognostic and biological significance in @entity0 ( @entity0 ). A quantitative reverse transcription PCR assay was performed to detect the expression of @entity26605 in 15 pairs of @entity0 and corresponding noncancerous tissues. The expression of @entity26605 was detected in another 110 @entity0 tissues and its correlations with clinicopathological factors of @entity1 were examined. Univariate and multivariate analyses were performed to analyze the prognostic significance of @entity26605 expression. The effects of @entity26605 expression on malignant phenotypes of @entity0 cells and its possible molecular mechanisms were further determined. @entity26605 was significantly downregulated in @entity0 tissues, and low @entity26605 expression was significantly correlated with lymph node @entity3 and advanced clinical stage. @entity1 with low @entity26605 showed poorer overall survival than those with high @entity26605 . Multivariate analyses indicated that status of @entity26605 was an independent prognostic factor for @entity1 . Functional analyses showed that upregulation of @entity26605 significantly inhibited growth, enhanced apoptosis, and reduced migration and invasion in @entity0 cells by targeting the protooncogene @entity4042 . Therefore, @entity26605 may be a potential biomarker for predicting the survival of @entity0 @entity1 and might be a molecular target for treatment of @entity1 BCs.
