A study on the cause of XXXX produced by angusticeps-type toxin F7 isolated from eastern green mamba venom.

@entity4033 @entity101 @entity19 @entity1576 @entity3897 @entity35 @entity943 @entity1168 @entity204
The cause of @entity204 due to toxin F7, an angusticeps-type toxin, isolated from the venom of Dendroaspis angusticeps was studied in anesthetized @entity19 . The carotid arterial blood pressure, the ECG and the @entity1576 were recorded. Within a few minutes after i.v. injection of F7 (1 mg/kg), both the rate and amplitude of the @entity1576 decreased and @entity1576 took place within 15 min in most cases. Before @entity1576 , marked @entity1168 with various types of @entity943 and oscillation of blood pressure were observed. Artificial ventilation could abolish these cardiovascular changes and maintain the blood pressure for a long period. Toxin F7 caused a transient and slight @entity101 which could be prevented by @entity4033 . Intracisternal application of F7 (1 mg/kg) caused a long-lasting @entity101 and @entity1168 and the @entity1576 time was significantly longer than after i.v. injection. A large dose (50 mg/kg i.p.) of @entity3897 , but not smaller doses (5-10 mg/kg), protected @entity19 against @entity1576 induced by F7. In @entity35 , the phrenic nerve discharge was prolonged during @entity1576 . Since F7 has a potent anticholinesterase activity, it is concluded that the @entity1576 induced by F7 is peripheral in origin, chiefly, if not entirely, due to its anticholinesterase activity.
