The association between leptin and XXXX is lost with @entity1144 .

@entity1 @entity28 @entity2270 @entity2690 @entity1386 @entity1144 @entity413 @entity1720 @entity65
OBJECTIVE: Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the @entity1720 that are linked to the prospective risk of @entity65 . Whether the association between leptin and @entity2690 is different between groups displaying different degrees of risk for @entity65 is not known. We therefore examined this association in @entity1 versus @entity1 and in pre- versus postmenopausal @entity1 from a population-based sample. DESIGN AND SUBJECTS: Healthy subjects (n = 158; 85 @entity1 and 73 pre- and postmenopausal @entity1 ) from the Northern Sweden Monitoring of Trends and Determinants in @entity65 population were studied with a cross-sectional design. METHODS: Anthropometric measurements (body mass index and waist circumference) and oral @entity413 tolerance tests were performed. Enzyme-linked immunosorbent assays were used for the analyses of specific insulin and @entity2690 , and radioimmunoassay for leptin. Insulin resistance and beta-cell function were calculated according to the homeostasis assessment model. Partial correlation coefficients adjusted for age and measures of @entity1386 were calculated and multiple linear regression analyses were performed with leptin as dependent variable. RESULTS: In nonobese @entity1 and premenopausal @entity1 and in @entity28 postmenopausal @entity1 , leptin was significantly associated with @entity2690 after stratification for waist circumference. Furthermore, a multivariate analyses taking age and measures of @entity1386 into account, showed that high fasting @entity2690 was a significant predictor of high leptin in these groups. In contrast, this association was lost with @entity1144 in @entity1 and premenopausal @entity1 . CONCLUSIONS: This study shows that both the degree of @entity1386 and the hormonal milieu influence the association between circulating leptin and @entity2690 in a normal population. Therefore, the @entity1720 seems to be characterized by lost association between leptin and @entity2690 , which may be explained by dysfunction in the @entity2270 .
