XXXX pathway is up regulated in @entity976 .

@entity1 @entity26775 @entity1357 @entity2751 @entity3546 @entity8889 @entity4611 @entity4851 @entity976 @entity25181 @entity2750
UNASSIGNED: Objectives: Pituitary stem cells play a role in the oncogenesis of @entity1 @entity976 ( @entity976 ). We hypothesized that crosstalk between the Wnt/ @entity3546 and @entity4851 ( @entity4851 ) pathways, both of which are important in normal pituitary development, would contribute to the pathogenesis of @entity976 . Design: To explore the mRNA and protein expression of components of the @entity4851 signaling pathway in @entity976 and their relationship with the identification of @entity3546 / @entity3546 mutations and @entity1 outcomes. @entity1 _ Methods: In 18 aCP samples, @entity3546 was sequenced, and the mRNA expression levels of @entity4851 pathway members ( @entity4851 , @entity2750 , @entity2751 , @entity8889 , @entity1357 , @entity26775 and @entity25181 ) and @entity2751 , @entity8889 , @entity26775 , @entity25181 , @entity3546 , and Ki67 proteins were evaluated by qPCR and immunohistochemistry, respectively. Anterior normal @entity4611 were used as controls. Associations between molecular findings and clinical data were analyzed. Results: The @entity976 presented higher mRNA expression of @entity4851 (+400-fold change [FC]; P<0.01), @entity8889 (+102-FC; P<0.001) and @entity26775 (+5.1-FC; P<0.01) than normal anterior @entity4611 . Longer disease-free survival was associated with low @entity2751 and @entity25181 mRNA expression (P<0.01 and P=0.02, respectively). @entity3546 / @entity3546 mutations were found in 47% of the samples. @entity976 with identified mutations presented with higher mRNA expression of @entity2751 and @entity8889 (+4.3-FC; P=0.02 and +10.2-FC; P=0.03, respectively). @entity2751 , @entity8889 , @entity26775 , and @entity25181 staining was found in 85%, 67%, 93%, and 64% of the samples, respectively. Strong @entity8889 and @entity26775 staining was detected in palisade cells, which also labeled Ki67, a marker of cell proliferation. Conclusions: The upregulation of @entity4851 signaling occurs in @entity976 . Thus, activation of Wnt/ @entity3546 and @entity4851 pathways, both of which are important in pituitary embryogenesis, appears to contribute to the pathogenesis of aCP.
