Central nervous system side effects of first- and second-generation antihistamines in school XXXX with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study.

@entity1 @entity2023 @entity8610 @entity3493 @entity14746 @entity17567
OBJECTIVE: @entity2023 is common and on the rise. @entity8610 are the mainstay of treatment and are the most commonly prescribed drugs in Singapore. Treatment-related sedation and its effect on cognition are a major concern. First- and second-generation antihistamines show varying degrees of sedation, but to date, objective studies in @entity1 are lacking. The objective of this study was to assess the sedating effect of @entity14746 (second-generation antihistamine) and @entity17567 (first-generation antihistamine) compared with placebo using an objective neurophysiological test. METHODS: This was a prospective, double-blind, placebo-controlled, randomized, single-dose, 3-way crossover study. Twenty-four @entity1 aged 7 to 14 years with @entity2023 completed the study. All @entity1 were randomly allocated to medication sequences and received 3 different drugs on 3 different days, at least 1 week apart. The @entity3493 event-related potential was used as an objective test of sedation. Subjective assessment was by a visual analog scale. RESULTS: @entity17567 and @entity14746 increased @entity3493 latency when compared with baseline. No significant increase was obtained with placebo. The significant increase in @entity3493 latency was not accompanied by significant change in subjective somnolence as measured by the visual analog scale. CONCLUSION: We have shown that @entity14746 has sedative properties in @entity1 . The lack of correlation between @entity3493 latency and the visual analog scale indicates that sedation induced by these drugs may not be subjectively noted.
