XXXX of the skin. A clinicopathologic study of nine @entity1 .

@entity1 @entity5 @entity189 @entity13152 @entity1358 @entity3
BACKGROUND: Sweat @entity189 with clear cell features are extremely rare @entity5 , with few well documented cases reported in the literature. METHODS: Data on nine @entity1 with @entity5 characterized by a prominent clear cell neoplastic component were studied. Immunohistochemical stains with a panel of antibodies against epithelial, stromal, and neural antigens were performed on five @entity5 and electron microscopic examination of one. RESULTS: The @entity5 showed a spectrum of histologic features and growth patterns that ranged from well differentiated, low grade @entity5 to poorly differentiated, highly aggressive, recurrent, and metastasizing @entity5 . All @entity5 contained a varied proportion of cells with abundant clear cytoplasm, similar to those seen in a group of @entity5 that have been variously designated as clear cell hidradenoma, @entity13152 , @entity1358 , and eccrine @entity13152 . Immunohistochemical stains on five @entity5 and ultrastructural examination in one were consistent with eccrine differentiation. Clinical follow-up of eight @entity1 showed local recurrence in six, followed by metastases in three, despite local excision, radiation, and chemotherapy. Criteria for differentiating these @entity5 from their benign counterparts and from other types of @entity5 and metastatic lesions are presented. CONCLUSIONS: The findings indicate that @entity1358 comprise a heterogeneous group of lesions that may range from locally recurring, low grade well differentiated @entity5 to highly aggressive, high grade @entity5 with a definite potential for uncontrollable local recurrence and @entity3 . Wide surgical excision is recommended as the primary treatment for such @entity5 .
