@entity1311 and @entity3003 in neo-adjuvant and concomitant chemoradiotherapy in locally advanced XXXX .

@entity1 @entity1665 @entity137 @entity3480 @entity5 @entity3003 @entity33 @entity1311 @entity1398 @entity221 @entity213
AIM AND BACKGROUND: To evaluate feasibility of neoadjuvant chemotherapy (NA-CT) followed by CT + radiotherapy (RT) in locally advanced or unresectable @entity213 ( @entity213 ). METHODS: 22 @entity213 @entity1 were enrolled (18 males, 4 females; median age, 59.5 years; median ECOG PS, 1). Sites of disease: oral cavity, 18.2%; oropharynx, 40.9%; hypopharynx, 18.2%; larynx, 4.6%, multiple sites, 18.2%. @entity5 ( @entity5 ) category: T2, 13.6%; T3, 31.8%; T4, 54.5%. N (nodes) category: NO, 9.1%; N1, 18.1%; N2, 40.9%; N3, 31.8%. Stage: III, 4.6%; @entity3480 , 63.6%; IVB, 31.8%. Induction @entity3003 (AUC = 6) and @entity1311 (200 mg/m2) x 3 cycles (q21 days) were given. Responders received definitive radiotherapy with concurrent @entity3003 (35 mg/m2/day from days 1 to 5 in weeks 1, 3, 5 and 7) and @entity1311 (50 mg/m2 on days 10, 24 and 38). @entity1 with node involvement were suggested to undergo postradiotherapy neck dissection. RESULTS: NA-CT. 97% of planned chemotherapy cycles were administered. Prevalent @entity137 was hematologic: 50% G4 @entity1398 and 31.8% G3, one @entity221 . All @entity1 had @entity1665 . Complete responses in @entity5 and N were 4 (18.2%) and 3 (15%), respectively. Partial responses were 13(59%) and 9 (45%). There was 1 progressive disease. CT + RT. 79.9% of planned cycles of CT were administered. In 19 @entity1 (86.4%) more than 50% of planned cycles of CT were completed. Median dose of RT was 70.2 Gy on @entity5 /N+ and 54 Gy on NO. Limiting @entity137 was @entity33 in 77.3%, followed by @entity1398 (59.1% G3-G4). Median weight loss was 4.9%.18.2% of @entity1 required hospitalization. Complete responses in @entity5 and N were 15 (68.1%) and 8 (40%), respectively. Partial responses were 5 (22.7%) and 7 (35%). CONCLUSIONS: The preliminary results of this study are encouraging, despite the @entity137 . Adequate follow-up is required to evaluate efficacy in terms of local-regional control and overall survival.
