Evidence against cholinergic mediation of the effect of angiotensin II on the XXXX ileum.

@entity840 @entity1239 @entity12947 @entity3897 @entity112 @entity2607 @entity11348 @entity1812 @entity934
The belief that the smooth muscle contracting activity of angiotensin II (angiotensin) in the @entity840 ileum is partly mediated by release of @entity934 was reexamined, with the following results. 1. @entity3897 did not reduce the maximum contraction produced by angiotensin, although it caused a shift to the right of the log dose-response curve (dose ratio = 2.2). A similar shift was observed with @entity112 , @entity1812 and @entity12947 . 2. A moderate potentiation of angiotensin by @entity2607 was also observed, which was similarly found for the other agonists. 3. A previous report that @entity3897 blocks the fast (phasic) component of the isometric response of the ileum to angiotensin was not confirmed. The disappearance of the phasic component was found to be due to a tachyphylactic change in the response. 4. Depolarization by high doses of @entity1239 , and inhibition of @entity934 synthesis by @entity11348 , did not affect the response to angiotensin. 5. Ilei in which the intramural ganglia had been destroyed by incubation at 4 degrees 48-56 h responed maximally to angiotensin, without loss of the phasic component of the response. It is concluded that the available evidence does not support the participation of a cholinergic mechanism in the effect of angiotensin upon the @entity840 ileum.
