Administration of XXXX accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in @entity19 .

@entity82 @entity28 @entity6 @entity13088 @entity19 @entity24778 @entity998 @entity1386 @entity854 @entity164 @entity299 @entity413 @entity2729 @entity1168 @entity65
BACKGROUND/OBJECTIVES: @entity1386 ( @entity1386 ) is a major contributor to the development of @entity28 and @entity65 due to the induction of cardiac structural and @entity854 . We used a model of @entity13088 in C57Bl/6 @entity19 fed with a @entity1386 to investigate the effects of @entity24778 ( @entity24778 ), a cytokine known for its beneficial effects in the heart, on cardiac anatomical and functional abnormalities associated with @entity28 and @entity164 2 @entity6 . METHODS: Groups of C57Bl/6 @entity19 were fed with standard diet (n   =   8) or @entity1386 (n   =   16). After 36  weeks, @entity1386 animals were divided into a group treated with @entity24778   +   standard diet (n   =   8) and a vehicle control group + standard diet (n   =   8). Cardiac structure and function were assessed by electrocardiography, echocardiography and treadmill tests, in addition to the evaluation of body weight, fasting glicemia, insulin and @entity413 tolerance at different time points. Histological analyses were performed in the heart tissue. RESULTS: @entity1386 consumption induced metabolic alterations characteristic of @entity164 2 @entity6 and @entity28 , as well as @entity299 and reduced exercise capacity. Upon returning to a standard diet, @entity28 @entity19 body weight returned to non- @entity28 levels. @entity24778 administration accelerated the reduction in of body weight in @entity28 @entity19 . Additionally, @entity24778 treatment reduced insulin levels, diminished heart @entity82 , increased exercise capacity and reversed cardiac alterations, including @entity1168 , elevated QRS amplitude, @entity2729 , increased septal wall thickness, @entity998 . CONCLUSION: Our results indicate that @entity24778 administration caused beneficial effects on @entity28 -associated @entity299 .
