Lung fluid and protein exchange in the acute XXXX preparation.

@entity101 @entity1508 @entity742 @entity2507 @entity661 @entity22844
We examined the effect of left atrial @entity101 on lung fluid and protein exchange in acutely prepared anesthetized @entity742 . The results were compared with those reported by Erdmann jet al. (Circ. Res. 37:271-284, 1975) in chronically instrumented conscious @entity742 . Animals were anesthetized with @entity1508 and efferent duct of the caudal mediastinal node was cannulated. Pulmonary microvascular pressure ( @entity22844 ) was elevated by raising left atrial pressure with a left @entity661 . For every elevation in @entity22844 of 1 cm @entity2507 pulmonary lymph flow (Qlym) increased by 0.5 ml/h. Increasing the @entity22844 resulted in a linear decrease (p less than 0.05) in the ratio of lymph to plasma protein concentration as a result of a significant reduction in lymph protein concentration. Transvascular clearance of lymph proteins increased by 39% with a doubling of Qlym. The steady-state changes in pulmonary fluid and protein exchange induced by an increase in @entity22844 in acutely prepared anesthetized @entity742 were the same as those observed by Erdmann et al. in chronically instrumented unanesthetized @entity742 , indicating that the acute preparation is equally reactive to increase in @entity22844 and that the lung endothelial permeability is not increased.
