[Diffuse large B-cell XXXX initially manifesting in bone marrow. A case report].

@entity1 @entity706 @entity75 @entity2225 @entity2590 @entity1358 @entity236 @entity221
We presented the case of diffuse large B-cell @entity706 initially manifesting in bone marrow without lymph nodes' swelling and other @entity75 . A 68-year-old @entity1 was suffering from general fatigue and @entity221 . Because @entity1358 were identified in the peripheral blood, a @entity236 and random skin biopsy were performed. In myelogram, it was suspicious for @entity2590 because @entity706 cells resembled other atypical hematopoietic cell. In biopsy specimen of bone marrow, @entity1358 diffusely infiltrated, which could be called "paced bone marrow". On the other hand no atypical cell identified in the vessels of dermis and subcutaneous tissue by random skin biopsy. Immunohistochemically, @entity1358 in bone marrow were diffusely positive for B-cell marker ( @entity2225 ). These results lead this case to be diagnosed as diffuse large B-cell @entity706 initially manifesting in the bone marrow. In this case, it was very useful that bone marrow biopsy and myelogram were evaluated simultaneously. Quick and accurate diagnosis is possible by combining immunohistochemical analysis using both myelogram and biopsy specimen.
