Effects of preoperative nutritional support on colonic anastomotic healing in malnourished XXXX .

@entity35 @entity720 @entity3147
OBJECTIVE: It has been proven that @entity3147 increases postoperative morbidity and mortality, and it may also negatively affect wound healing in the gastrointestinal tract. In the literature, there is only one study evaluating the effects of preoperative nutritional support on colonic anastomotic healing under malnourished conditions. In order to improve the data on this topic, an experimental study was planned to evaluate the effects of preoperative nutritional support on colonic anastomotic healing in malnourished @entity35 . MATERIAL AND METHODS: The study included 18 male @entity35 albino @entity35 divided into 3 groups. The control (C) group was fed ad libitum for 21 days. The @entity3147 ( @entity3147 ) group and preoperative nutrition (P) group were given 50% of the daily food consumed by the @entity35 in Group C for 21 days to induce @entity3147 . At the end of 21 days, Group P was fed ad libitum for 7 days (preoperative nutritional support). Colonic transection and end-to-end anastomosis was performed at 21 days in Group C and Group @entity3147 and at 28 days in Group P. The @entity35 were sacrificed at postoperative 4 days, anastomotic bursting pressure was measured, and samples were taken to analyze tissue @entity720 levels. RESULTS: Anastomotic bursting pressure was significantly higher in Group C than in Group @entity3147 and Group P (p<0.05), and it was significantly higher in Group P than in Group @entity3147 (p<0.05). Tissue @entity720 levels in Group P were found to be significantly higher than those in Group @entity3147 and Group C (p<0.05). CONCLUSION: One week of preoperative nutritional support increases collagen synthesis in the colon and positively affects anastomotic healing under malnourished conditions.
