Predictive value of @entity6949 and T for subsequent XXXX in @entity454 .

@entity1 @entity6949 @entity10020 @entity453 @entity204 @entity454
BACKGROUND: This study determined the prevalence of increased @entity6949 ( @entity6949 ) and T ( @entity10020 ) in @entity454 ( @entity454 ) @entity1 and whether an increased troponin was predictive of @entity204 . METHODS AND RESULTS: Serum was obtained from 733 @entity454 @entity1 and measured for @entity6949 and @entity10020 . Relative risks were estimated using Cox proportional hazards regressions univariately and adjusted for age, time on dialysis, and @entity453 . Kaplan-Meier curves compared time to event data between groups. Greater percentages of @entity1 had an increased @entity10020 versus @entity6949 at each cutoff, as follows: 99th percentile, 82% versus 6%; 10% coefficient of variation, 53% versus 1.0%; and receiver operator characteristic, 20% versus 0.4%. Increased versus normal @entity10020 was predictive of increased mortality using all cutoffs and only above the 99th percentile for @entity6949 . Two-year cumulative mortality rates increased (P<0.001) with changes in @entity10020 from normal (<0.01 microg/L, 8.4%) to small (> or =0.01 to <0.04 microg/L, 26%), moderate (> or =0.04 to <0.1 microg/L, 39%), and large (> or =0.1 microg/L, 47%) increases. Two-year mortalities were 30% for @entity6949 <0.1 microg/L and 52% if > or =0.1 microg/L. Univariate and adjusted relative risks of @entity204 associated with elevated (>99th percentile) @entity10020 were 5.0 (CI, 2.5 to 10; P<0.001) and 3.9 (CI, 1.9 to7.9; P<0.001) and @entity6949 were 2.0 (CI, 1.3 to 3.3; P=0.008) and 2.1 (CI, 1.3 to 3.3; P=0.007). Age, @entity453 , and time on dialysis were also independent predictors of mortality. CONCLUSIONS: Increases in @entity10020 and @entity6949 in @entity454 @entity1 show a 2- to 5-fold increase in mortality, with a greater number of @entity1 having an increased @entity10020 .
