Effect of @entity1718 on @entity53 and XXXX binding to whole DU-145 prostate cells.

@entity1 @entity172 @entity5204 @entity251 @entity263 @entity1718 @entity7784 @entity8393 @entity5 @entity4785 @entity1474 @entity53 @entity134 @entity1068 @entity342 @entity105 @entity7461 @entity204 @entity3800
@entity263 is one of the leading causes of @entity5 related @entity204 in @entity1 . An important role in the development of @entity263 is played by @entity3800 and @entity342 ablation is therefore currently used in @entity5 treatment. In the past, @entity172 were widely used in treatment of @entity263 , but there are indications that @entity172 could also be involved in @entity105 . Lately, much research has been done on the modulation of the binding of @entity134 hormones to their receptors by @entity1474 ( @entity5204 ), which could interfere with the @entity134 hormone's message. Therefore, the aim of this study was to determine in whole DU-145 @entity1 prostate cells the effect of EFAs and their metabolites on the binding and affinity of the @entity172 receptor (ER) and @entity342 receptor (AR) to @entity53 (E(2)) and @entity251 (T), respectively. @entity1718 were dissolved in @entity1068 and added to the cell culture in a final @entity1068 concentration of 0.2% on the fourth day of incubation. The results showed that the @entity5204 under investigation inhibited the AR's capacity, in contrast to the ER's capacity which was stimulated. However, the dissociation constants (K(d)) of the AR and ER complexes in the presence of the @entity5204 , were as follows. Except for @entity7784 ( @entity8393 ) which decreased the @entity4785 constant and EPA and @entity7461 (ALA) which increased the ER dissociation constant, the remaining FAs had no significant effect on the K(d) values of both the AR and ER complexes. According to these priliminary results it is postulated that @entity1 should benefit with a diet rich in certain essential @entity1474 although its function remains to be clarified.
