Solid-State and Solution Characterization of XXXX .

@entity3091 @entity19 @entity1489 @entity17054 @entity1996
UNASSIGNED: @entity3091 ( @entity17054 ) is a natural compound that has been investigated as a chemopreventative agent. @entity17054 has been shown to suppresses ultraviolet B (UVB)-induced @entity1996 ( @entity1996 ) protein expression and reduce the incidence of UVB-induced @entity1489 in @entity19 . Despite @entity17054 's promise as a therapeutic agent, minimal information is available to guide the progression of formulations designed for future drug development. Here, data is presented describing the solid-state and solution characterization of @entity17054 . Investigation into the solid-state properties of @entity17054 identified four different crystal forms, two hydrates ( @entity17054 I and @entity17054 II) and two metastable forms ( @entity17054 IA and @entity17054 IIA). From solubility studies, it was evident that all forms are very insoluble (<5  g/ml) in pure water. @entity17054 I was found to be the most stable form at 23, 35, and 56  C. Stability determination indicated that @entity17054 undergoes rapid apparent first-order degradation under basic pH conditions, and that degradation was influenced by buffer species. Apparent first-order degradation was also seen when @entity17054 was introduced to an oxidizing solution. Improved stability was achieved after introducing 0.1% antioxidants to the solution. @entity17054 was found to have good stability following exposure to ultraviolet radiation (UVR), which is a consideration for topical applications. Finally, a partitioning study indicated that @entity17054 possess a log P of 2.94 which, along with its solid-state properties, contributes to its poor aqueous solubility. Both the solid-state properties and solution stability of @entity17054 are important to consider when developing future formulations.
