Effect of XXXX on airway responsiveness in ovalbumin sensitized @entity840 .

@entity32 @entity620 @entity565 @entity840 @entity2710
OBJECTIVE: The most important pathological feature of @entity565 is @entity32 , which results in airway hyper-responsiveness. We hypothesized that excessive oxidation is likely to contribute to @entity32 in @entity565 . The aim of this study was to evaluate the effects of both acute exposure and a 30-day administration of @entity620 (AA), which has an antioxidant effect, on airway responsiveness in sensitized @entity840 . METHODOLOGY: @entity840 sensitized to ovalbumin (OA), were given drinking water without AA (group 2) or with AA (group 3). The responses of tracheal chains of control animals (group 1) and both groups of sensitized @entity840 (n = 10, for all groups) to cumulative concentrations of @entity2710 were measured, and the effective concentrations of @entity2710 causing 50% of maximum response (EC50 M) were obtained. The response of tracheal chains to 0.1% OA, relative to contraction obtained with 10 micro mol/L @entity2710 , was also measured. The tracheal responses to @entity2710 and OA were measured on tissues both incubated and not incubated with AA. RESULTS: The tracheal responses of group 2 tissues were significantly greater than those of groups 1 and 3 to both OA and @entity2710 (P < 0.05). There were no significant differences in tracheal responses to OA and @entity2710 between groups 1 and 3. Acute incubation of tissues caused a reduction of tracheal response to @entity2710 in all groups, but this was only significantly differ-ent for group 3 (P < 0.05). Acute incubation of tissues did not change tracheal response to OA significantly. CONCLUSION: These results showed that although short-term administration of AA had no major effect on tracheal responsiveness among sensitized animals, 30-day administration of AA could lead to a decrease in airway responsiveness of sensitized @entity840 to both OA and @entity2710 .
