High Incidence of @entity1289 / XXXX in Association to a Spectrum of Other Polymorphic Cardiovascular Genes Involving PBMCs Proinflammatory Cytokines in Hypertensive Hypercholesterolemic Patients: Reversibility with a Combination of @entity1289 Inhibitor and Statin.

@entity5337 @entity3372 @entity1289 @entity101 @entity2289 @entity9769 @entity310 @entity22653 @entity6817 @entity2993 @entity49 @entity3646 @entity24038 @entity379 @entity731 @entity688 @entity65
UNASSIGNED: @entity65 ( @entity65 ) are significantly high in the Lebanese population with the two most predominant forms being @entity731 and @entity49 . The purpose of our study was to assess the association of a spectrum of CVD related genes and combined state of @entity101 ( @entity101 ) in unrelated Lebanese. Twelve polymorphisms were studied by multiplex PCR and reverse hybridization of DNA from 171 healthy individuals and 144 @entity101 subjects. Two genes were significantly associated with @entity101 : @entity1289 (OR: 9.20, P<0.0001) and @entity2289 (OR: 2.29, P = 0.007), respectively with the occurrence of the risky alleles "Del" and "4G". The frequencies of the Del and 4G alleles were found to be 0.98 and 0.90 in the @entity101 group versus 0.84 and 0.79 in the healthy group, respectively. Serum @entity1289 activity and PAI-I increased significantly with Del/Del and 4G/5G genotypes. The co-expression of Del/4G(+/+) was detected in 113 out of 171 (66.0%) controls and 125 out of 144 (86.8%) @entity101 subjects. Del/4G(-/-) was detected in only 6 (3.5%) controls and undetected in the @entity101 group. Three @entity49 related genes [FV(Leiden), @entity9769 ( @entity24038 ) and FXIII( @entity22653 )] were significantly related to the prominence of the co-expression of Del/4G(+/+). A range of 2 to 8 combined polymorphisms co-expressed per subject where 5 mutations were the most detected. In Del/4G(+/+) subjects, peripheral blood mononuclear cells (PBMCs) produced significant elevated levels of @entity379 and @entity310 contrary to @entity688 , and no variations occurred for @entity3646 . @entity1289 inhibitor ( @entity3372 ) in combination with @entity6817 ( @entity2993 ) and not alone reversed significantly the situation. This first report from Lebanon sheds light on an additional genetic predisposition of a complex spectrum of genes involved in CVD and suggests that the most requested gene @entity5337 by physicians may not be sufficient to diagnose eventual future problems that can occur in the cardiovascular system. Subjects expressing the double mutations (Del/4G) are at high risk for the onset of @entity65 .
