45, XXXX : contrast of prenatal and postnatal diagnosis.

@entity1 @entity31370 @entity1032 @entity4998 @entity2650 @entity851 @entity2008 @entity2588 @entity790
The process of prenatal diagnosis is unique in that the diagnosis and prognosis are made without seeing the @entity1 . 45, @entity31370 presents a special problem in this regard. The phenotype of 45,X/46,XY postnatally diagnosed @entity1 (pediatric group) was compared to that of 6 fetuses who were diagnosed from 7,000 amniocenteses (prenatal group). These amniocenteses were performed primarily because of an increased risk of @entity2008 . The pediatric group (age birth-18 yr) were all phenotypically abnormal, although none were @entity1032 . Seven @entity1 presented with @entity4998 , while 2 had primary @entity2588 . Sexual assignment was changed in 2. Abnormalities included @entity790 , @entity2650 , undescended testes, and @entity851 . All 9 @entity1 required at least one surgical procedure. In contrast, the prenatally diagnosed fetuses (ages 3 months to 3 1/2 yr) were all phenotypically normal males. Four were noted to have male genitalia on ultrasonography. Thus, the phenotype of 45, @entity31370 in prenatally diagnosed fetuses can be markedly different from that of individuals diagnosed postnatally. This must be considered when counseling @entity1 .
