Vasoreactivity and @entity256 after coronary angioplasty in the XXXX @entity1707 model.

@entity1707 @entity39 @entity3361 @entity256 @entity750 @entity112 @entity731
BACKGROUND: The effect of coronary angioplasty on @entity3361 remains unknown. We examined the effects of balloon angioplasty, using an oversized balloon, on coronary hypercontraction and eventual @entity256 in a @entity1707 model of @entity3361 . METHODS: We performed balloon angioplasty, using an oversized balloon at the site of @entity3361 superimposed on @entity731 with 6 (group A, n = 14) or 1 (group B, n = 14) atmospheres of inflation pressure in miniature @entity1707 . Using coronary angiography we assessed the coronary basal diameter and diameter change in response to @entity112 and @entity750 before, immediately after, and 4 weeks after angioplasty. Histological examinations were performed immediately after and 4 weeks after the angioplasty. RESULTS: Before angioplasty, @entity112 - and @entity750 -induced hypercontraction was reproducibly noted at the @entity731 site. Immediately after angioplasty, the coronary diameter became larger (P < 0.01) than before angioplasty in group A, but there was no significant difference in group B. The hypercontraction in group A was abolished immediately after and 4 weeks after angioplasty, whereas the hypercontraction in group B was unchanged. Histological examination revealed medial @entity39 immediately after and medial fibrosis 4 weeks after angioplasty, which were more prominent in group A. Four weeks after angioplasty, the magnitude of @entity256 was greater in group A than in group B. CONCLUSIONS: Angioplasty using an oversized balloon with the higher atmosphere of inflation pressure abolished coronary hypercontraction immediately after and 4 weeks after angioplasty, which probably resulted from the irreversible damage to medial smooth muscles; however, this did not prevent @entity256 .
