[First outbreak of botulism caused by XXXX subtype Af].

@entity1 @entity19 @entity6940 @entity4968 @entity204 @entity6938
In December 1982 an @entity6938 presumably produced by the ingestion of home-made pickled trout occurred in San Rafael, province of Mendoza, Argentina. The toxin detected in blood serum and feces samples of the sole affected @entity1 was preliminarily typed as a plain type A. A strain of @entity6940 was isolated from feces which, after culture by the dialysis method, produced 1 x 10(7) LD50/ @entity19 per ml. Quantitative neutralization tests carried out at different levels of toxin concentration, showed that this toxin consists of a major type A antigenic component (about 99% of the complex) and a minor type F component, defining its identity as a subtype Af. A rabbit antiserum obtained from this toxin neutralizes A and F reference toxins. Despite the antitoxic and supportive treatment, the @entity1 died as a consequence of the @entity4968 . The polyvalent antiserum administered contained A, B and E antitoxins. @entity204 could be due to the lethal effect of the A fraction, the F fraction or to a combined effect of both toxic components of the toxin. This is the first detection of an outbreak produced by @entity6940 subtype Af, serotype described in Argentina fifteen years ago, and not detected until now in other parts of the world.(ABSTRACT TRUNCATED AT 250 WORDS)
