Real-time monitoring of spatial and temporal metabolic changes during focal XXXX in rats.

@entity2125 @entity2806 @entity63 @entity2500 @entity16 @entity26 @entity519
Focal @entity2806 creates a gradual injury, ranging from severe injury in the core towards moderate @entity16 . Disruption of blood supply leads to shortage in @entity26 supply, resulting in mitochondrial disruption in the @entity63 area. The present work study the mitochondrial function and microcirculatory blood supply in the core and penumbra of the @entity63 tissue following different @entity63 durations. Focal @entity63 was obtained by @entity2500 ( @entity2500 ). Monitoring of the brain was conducted using a unique multi-site-multi-parametric (MSMP) monitoring system, which enables real-time, in vivo, simultaneous and continuous monitoring of mitochondrial @entity2125 and CBF. Short sessions of @entity519 before @entity63 and following reperfusion were used to test the ability of the tissue to respond to such metabolic challenges. Following focal @entity63 , CBF levels decreased and @entity2125 levels increased and recovered at reperfusion. These changes were more severe in the core compared to the penumbra. Longer @entity63 duration led to an increase in @entity26 demand following reperfusion and to vast disruption of blood supply, as seen during short anoxic exposures. In conclusion, the ability of mitochondrial activity and blood supply to recuperate following @entity63 , as well as the ability of the tissue to cope with metabolic challenges, varies in the core and the penumbra and depends on @entity63 duration. The MSMP monitoring system, used in the current study, can add valuable information regarding the metabolic state of the brain during focal @entity63 .
