Cognitive enhancing effect of XXXX -converting enzyme inhibitors and @entity7774 receptor blockers on learning and memory.

@entity917 @entity1314 @entity3372 @entity2475 @entity7774 @entity2730 @entity9886 @entity4833 @entity1062 @entity71128 @entity35 @entity5591 @entity4687
OBJECTIVE: The present study was designed to investigate cognitive enhancing property of @entity7774 -converting enzymes inhibitors (ACEI) and @entity7774 receptor blockers (ARBs) in @entity35 . MATERIALS AND METHODS: The elevated plus maze (EPM), @entity1314 ( @entity1314 ), and @entity1062 ( @entity1062 ) were used to assess cognitive enhancing activity in young and aged @entity35 . @entity3372 (10 mg/kg, p.o.), @entity4687 (10 mg/kg, i.p), @entity9886 (20 mg/kg, i.p), and @entity917 (20 mg/kg, p.o) were administered to assess their effect on learning and memory. @entity5591 (1 mg/kg, i.p) was used to impair cognitive function. @entity2475 (200 mg/kg, i.p) was used as reference drug. RESULTS: All the treatments significantly attenuated @entity2730 induced by aging and @entity5591 . In EPM, aged and @entity5591 -treated @entity35 showed an increase in transfer latency (TL) whereas, ACEI and ARBs showed a significant decrease in TL. Treatment with ACEI and ARBs significantly increased step down latencies and decreased latency to reach the platform in target quadrant in young, aged and @entity5591 -treated animals in @entity1314 and @entity1062 , respectively. The treatments inhibited @entity4833 ( @entity4833 ) enzyme in the brain. Similarly, all the treatments attenuated @entity5591 -induced lipid peroxidation and normalize antioxidant enzymes. CONCLUSION: The results suggest that the cognitive enhancing effect of ACEI and ARBs may be due to inhibition of @entity4833 or by regulation of antioxidant system or increase in formation of @entity71128 .
