Radio-frequency tissue ablation of the liver: effects of @entity432 on lesion diameter and biliary and portal damages in a XXXX model.

@entity1707 @entity75 @entity887 @entity432 @entity715
The aim of this study was to assess the effect of @entity432 on radio-frequency (RF) lesion size and on potential associated biliary and portal lesions. Radio-frequency lesions using a 1-cm exposed-tip cooled electrode were created in @entity1707 liver. Liver perfusion was modified by arterial @entity887 (n=2), left portal clamping (n=2), and both (n=2). Two @entity1707 were used as controls. Two weeks after, control portography was performed, animals were killed, and ex-vivo cholangiography was carried out. Pathological studies evaluated the lesion surface and associated portal and biliary damages. A mathematical regression model showed that portal occlusion increased by 43 mm2 (+40%) the surface of @entity75 , @entity432 by 135 mm2 (+126%), and associated occlusion by 466 mm2 (+435%). Biliary stenoses were found in 4 cases (two @entity432 , one portal occlusion, and one associated occlusion). One case of partial portal vein @entity715 was found in one case of portal occlusion and resolved at 2 weeks. Ischemic damages adjacent to @entity75 were found in cases of combined occlusions. The reduction of liver perfusion increases significantly the size of @entity75 but is associated with a risk of biliary, portal, or parenchymal complications.
