Intima-media thickness and XXXX in the Helsinki study of very low birth weight adults.

@entity1 @entity384 @entity1017 @entity731 @entity121 @entity65
BACKGROUND: Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for @entity65 , including higher blood pressure and insulin resistance. OBJECTIVE: We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and the relationship of these signs with postnatal growth. METHODS: We compared 92 with a VLBW with 68 who were born at term. At age 18 to 27, we measured stiffness and @entity121 ( @entity121 ) of the right carotid artery and @entity384 ( @entity384 ) of the right brachial artery. RESULTS: Those with a VLBW had 1.1% units higher @entity384 (95% confidence interval [CI]: 0.0-2.2) (P = .06) and 0.5% units higher @entity121 relative to lumen size (95% CI: 0.1-0.9). @entity121 or @entity384 , when analyzed as the absolute change in millimeters, and carotid stiffness in the groups were similar. Among those with a VLBW, each 100-g-greater @entity1017 during the first 2 postnatal weeks predicted 1.1% units higher @entity384 (95% CI: 0.2-2.0) in adulthood. CONCLUSIONS: Although young adults born at VLBWs, compared with those born at term, have higher levels of risk factors for @entity65 , we found no clear evidence for elevated early markers of @entity731 . However, in relation to artery lumen diameter, @entity121 in the @entity1 who had a VLBW was higher than in those who were born at term. In our study, @entity1017 during the first postnatal weeks had no harmful effect on the arteries in young adulthood.
