XXXX Emulsion Infusion Into the Carotid Artery Increases Brain Permeability to Anticancer Agents.

@entity632 @entity1313 @entity900 @entity95 @entity35 @entity18050
BACKGROUND: @entity18050 emulsion infusion into the carotid artery has been reported to induce temporary and reversible opening of the blood-brain barrier by increasing vascular permeability. OBJECTIVE: To evaluate the effect of @entity18050 emulsion infusion on brain permeance by anticancer agents. METHODS: In the @entity632 study. 2.4 mg/kg @entity632 was injected immediately after @entity18050 emulsion (1%, 1.5%, and 2%) infusion into @entity95 carotid arteries. Two hours later, bilateral hemispheres and eyeballs were harvested, and @entity632 concentrations were measured fluorometrically. @entity632 ratios of ipsilateral/contralateral hemispheres were compared with those of @entity632 controls by use of the Kruskal-Wallis test followed by the Dunn test. In the @entity900 study, 10 mg/kg @entity900 was injected immediately after 2% @entity18050 emulsion infusion into @entity35 carotid arteries. Ipsilateral hemispheres were harvested 2, 6, 12, 24, and 36 hours after treatment. Time-dependent @entity900 concentrations were determined by liquid chromatography/electrospray ionization-tandem mass spectrometry/mass spectrometry. RESULTS: @entity632 concentrations were significantly higher in ipsilateral hemispheres and eyeballs in all 3 @entity18050 treatment groups than in @entity632 controls. In the @entity900 study, @entity900 concentrations in the ipsilateral hemispheres peaked at 6 hours after infusion of @entity900 . CONCLUSION: Brain permeance to anticancer agents was increased by @entity18050 emulsion infusion, which suggests that @entity18050 infusion might be a useful adjuvant treatment for @entity1313 . ABBREVIATIONS: BBB, blood-brain barrierHPLC, high-performance liquid chromatographyLC/ESI-MS/MS, liquid chromatography/electrospray ionization-tandem mass spectrometry/mass spectrometry.
