[Treatment of XXXX in the @entity1 using @entity3524 ].

@entity1 @entity1276 @entity693 @entity3524 @entity6932 @entity526
@entity3524 has a good meningeal diffusion and is effective at low concentrations on many bacteria, especially ampicillin resistant Enterobacteriaceae and @entity6932 . We have therefore used @entity3524 (150 mg/kg/24 h, continuous infusions lasting 30 minutes q. 6 h.) in @entity693 due to gram negative bacilli. Twenty eight @entity1 and @entity1 have been treated within 4 years. The 13 @entity6932 (including 2 beta-lactamase producers) have been cured without immediate sequelae. The duration of treatment could be reduced from 3 weeks to 2 weeks. The 7 @entity1 with Enterobacteria @entity693 (6 @entity526 and 1 Serratia) have been cured of their infection with a 21 to 28 days treatment. The C.S.F. was sterile 2-3 days after treatment except a case of @entity526 persisting during 7 days in C.S.F. contrasting with a normal ventricular fluid. A case of relapse with @entity526 remaining sensitive was cured with a new course of the same treatment. Five @entity693 complicated with @entity1276 needed external drainage: the fluid was sterile 1 day after treatment in 4 of them. Two superinfections of ventriculo-peritoneal shunt due to Enterobacteriaceae have been cured. To obtain a good result, the need for a careful drug monitoring must be emphasized.
