Intracranial traumatic and non-traumatic @entity548 complications of XXXX treatment.

@entity1 @entity101 @entity548 @entity510 @entity130 @entity66 @entity1229
An increased referral of patients with anticoagulation related @entity548 necessitated an analysis of causes and outcome of these complications in a @entity1 group that reflected Swedish therapeutic traditions of anticoagulation treatment. Prospectively, all @entity1 from Stockholm evaluated for @entity1229 related intracranial @entity548 occurring during 1987 were analysed and their 6 month outcome recorded. Sixty-eight @entity1 were included. The results of @entity548 were catastrophic with a 77% mortality rate. Their incidence was much higher than expected. Forty-one @entity1 had non-traumatic intracerebral haematomas, 1 had a non-traumatic @entity510 and 26 had @entity130 . In the 42 @entity1 with non-traumatic @entity548 , the indications for anticoagulation were cerebral ischaemic events in a majority (27/42). The remaining 15 @entity1 had different indications for anticoagulation. They also had an increased frequency of @entity101 (p < 0.05). In the 26 @entity1 with traumatic haematomas, only 6/26 @entity1 had previous cerebral @entity130 (p < 0.01). Valvular heart prosthesis was their most common indication (11/26) for anticoagulation. Caution in instituting anticoagulation therapy in @entity1 with @entity101 or @entity66 , which is an important indication for anticoagulation in Sweden, is mandatory. Adherence to strict treatment regimens and their continuous reevaluation may help to avoid complications. The finding of more @entity1 than expected with @entity548 complications is not compatible with the risk evaluations used to justify anticoagulation therapy in the @entity1 groups studied. Clinical practice must have changed with time, showing that risk evaluations from controlled trials or retrospectively collected clinical data from selected @entity1 are not necessarily applicable for long-term clinical practice.
