Predictors of pathologic stage in @entity263 . The role of XXXX .

@entity1 @entity263 @entity5 @entity75 @entity2295 @entity189 @entity3 @entity1486 @entity5436
BACKGROUND: @entity263 is a significant cause of morbidity and mortality in older @entity1 . However, the histologic prevalence far exceeds clinically manifest disease. Increased screening has resulted in the detection of a large number of @entity189 of unknown malignant potential. The authors investigated @entity5 angiogenesis to predict pathologic stage in @entity263 . Angiogenesis in @entity5436 ( @entity5436 ), a putative @entity75 , also was investigated. METHODS: Immunohistochemistry was used to highlight the @entity5 vasculature. Vessels were quantified using computerized image analysis. A minimum of five randomly selected microscopic fields were measured from each @entity5 . To investigate @entity5436 , the authors measured vessels per millimeter of gland perimeter, compared with benign glands in the same @entity1 . RESULTS: Vessel density (vessels per millimeter squared [vv/mm2]) correlated with pathologic stage. The mean vessel density of organ-confined @entity5 was 80.2 vv/mm2 (95% confidence interval [CI], 71.4-91.0), compared with 110.4 vv/mm2 (95% CI, 97.9-122.8) for @entity5 with capsular penetration or positive lymph nodes. Logistic regression analysis and modeling showed vessel density superior to histologic grade and preoperative @entity1486 level in distinguishing organ-confined @entity5 from those having extracapsular extension or pelvic lymph node @entity3 . @entity5436 in acini and ductules had increased microvascularity relative to benign epithelium in 18 of 25 @entity5 (P < 0.05). CONCLUSIONS: @entity2295 has been demonstrated to be a prerequisite for @entity5 progression. These data demonstrate that microvessel density in @entity263 is an independent predictor of pathologic stage and, presumably, malignant potential. Quantification of @entity5 angiogenesis may allow stratification of @entity1 to type of treatment and may allow selection of expectant management for @entity1 with low @entity5 microvessel density.
