Effects of delayed administration of low-dose XXXX on transient focal @entity2806 in @entity35 .

@entity353 @entity2806 @entity63 @entity75 @entity1711 @entity3303 @entity1710 @entity1188 @entity35
BACKGROUND: The authors' previous study demonstrated that a clinical antiarrhythmic dose of @entity3303 , when given before @entity63 , is neuroprotective in a @entity35 model of transient focal @entity2806 . In this study, the authors investigated whether the administration of this dose of @entity3303 , when delayed until 45 min after the onset of @entity63 , also reduces @entity2806 . METHODS: @entity3303 was administered as an intravenous bolus (1.5 mg/kg) followed by an intravenous infusion (2 mg. kg(-1).h(-1)) for 165 min, beginning 45 min after the onset of a 90-min period of transient focal @entity2806 . Control animals were given the same volume of saline. Focal @entity2806 was induced by occluding the right middle cerebral artery using an intraluminal suture. Neurologic outcome and body @entity353 were quantified 7 days later. The brain was fixed 7 days after @entity63 and brain sections were stained with @entity1710 and @entity1711 for assessment of infarct size and the number of intact neurons. In separate experiments, local cerebral blood flow and the electroencephalogram were measured during @entity63 and 180 min into the reperfusion period. @entity1188 size was assessed after 24 h. RESULTS: @entity1188 size, at either 24 h or 7 days after @entity63 , was not significantly reduced in the @entity3303 group. However, the number of intact neurons was significantly increased in both the @entity63 penumbra and core of the @entity3303 group 7 days after @entity63 , compared with the vehicle group. @entity35 treated with @entity3303 demonstrated better neurologic outcome and less @entity353 (P < 0.05). @entity3303 treatment had no significant influence on local cerebral blood flow and electroencephalogram during @entity63 and reperfusion. CONCLUSIONS: Administration of a clinical antiarrhythmic dose of @entity3303 , beginning 45 min after the onset of @entity63 , reduces @entity2806 after transient focal @entity2806 in the @entity35 . This indicates that delayed administration of neuroprotective agents may reduce @entity75 resulting from @entity63 .
