Inhibition of @entity1110 oxidase activation reduces XXXX -induced white matter damage in @entity19 .

@entity6504 @entity17 @entity3026 @entity12824 @entity19 @entity26 @entity1110 @entity1961 @entity25234 @entity6503 @entity15
BACKGROUND: To evaluate the role of @entity1110 oxidase-mediated reactive @entity26 species (ROS) production in @entity15 pathogenesis, we examined the effects of @entity12824 , an @entity1110 oxidase assembly inhibitor, on @entity6503 ( @entity6503 ). METHODS: @entity6503 was induced by immunization with @entity6504 ( @entity6504 (35-55)) in C57BL/6 female @entity19 . Three weeks after initial immunization, the @entity19 were analyzed for @entity17 , immune cell infiltration, and ROS production. @entity12824 (30  mg/kg) was given orally once daily for the entire experimental course or after the typical onset of clinical symptom (15  days after first @entity6504 injection). RESULTS: Clinical signs of @entity6503 first appeared on day 11 and reached a peak level on day 19 after the initial immunization. The daily clinical symptoms of @entity6503 @entity19 were profoundly reduced by @entity12824 . The @entity12824 -mediated inhibition of the clinical course of @entity6503 was accompanied by @entity17 , reduced infiltration by encephalitogenic immune cells including @entity1961 , CD8, @entity25234 , and @entity19 -positive cells. @entity12824 reduced @entity6504 -induced pro-inflammatory cytokines in cultured microglia. @entity12824 also remarkably inhibited @entity6503 -associated ROS production and blood-brain barrier (BBB) disruption. Furthermore, the present study found that post-treatment with @entity12824 also reduced the clinical course of @entity6503 and @entity3026 . CONCLUSIONS: These results demonstrate that @entity12824 inhibits the clinical features and neuropathological changes associated with @entity6503 . Therefore, the present study suggests that inhibition of @entity1110 oxidase activation by @entity12824 may have a high therapeutic potential for treatment of @entity15 pathogenesis.
