XXXX after liver transplantation as a consequence of immunosuppression: univariate and multivariate analysis of risk factors.

@entity1 @entity3470 @entity16 @entity2239
BACKGROUND: @entity16 ( @entity16 ) can frequently and significantly affect morbidity and mortality of liver transplant (LT) recipients. AIMS: We analysed incidence, risk factors, outcome and impact of the immunosuppressive therapy on NC development after LT. METHODS: We analyzed 478 LT in 440 @entity1 , 93 (19.5%) were followed by @entity16 . RESULTS: The average LOS was longer in @entity1 experiencing @entity16 . The 1-, 3- and 5-year graft and @entity1 survival was similar in @entity1 with or without a NC. Multivariate analysis showed the following as independent risk factors for NC: a MELD-score>= 20 (OR=1.934 CI=1.186-3.153) and an immunosuppressive regimen based on calcineurin inhibitors (CNIs) (OR=1.669 CI=1.009-2.760). Among @entity1 receiving an @entity2239 -based immunosuppression the 7.1% developed @entity16 , versus the 16.9% in those receiving a CNI(p=0.039). There was a 1-, 3- and 5-year NC-free survival of 81.7%, 81.1% and 77.7% in @entity1 receiving a CNI-based regimen and 95.1%, 93.6% and 92.7% in those not receiving a CNI-based regimen (p<0.001). CONCLUSIONS: In @entity1 undergoing a LT and presenting with non-modifiable risk factors for developing @entity16 an immunosuppressive regimen based on CNIs is likely to result in a higher rate of @entity16 compared to @entity3470 inhibitors. This article is protected by copyright. All rights reserved.
