@entity32 is more closely related to airway hyperresponsiveness to hypertonic saline than to XXXX .

@entity1 @entity32 @entity225 @entity565 @entity379 @entity2710 @entity1224
BACKGROUND: Airway hyperresponsiveness (AHR) to direct stimuli, such as @entity2710 (MCh), is observed not only in @entity565 but other diseases. AHR to indirect stimuli is suggested to be more specific for @entity565 . The purpose of this study was to determine whether @entity32 is more closely related to @entity1224 (HS), an indirect stimulus, than to MCh. METHODS: Sixty-four consecutive adult @entity1 with suspected @entity565 (45 @entity565 and 19 non- @entity565 ) performed a combined bronchial challenge and sputum induction with 4.5% saline, and MCh challenge on the next day. RESULTS: Both HS-PD15 and MCh-PC20 were significantly lower in @entity565 @entity1 than in non- @entity565 @entity1 . However, the sensitivity/specificity for @entity565 was 48.9%/100%, respectively, in the HS test and 82.2%/84.2%, respectively, in the MCh test. There was a significant relationship between HS-PD15 and MCh-PC20 and only 52.9% of @entity1 with MCh-PC20 < or = 4 mg/mL showed HS-AHR, but 4 @entity1 with HS-AHR showed MCh-PC20 > 4 mg/mL. There were significant correlations between both HS-PD15 and MCh-PC20 and FEV1, or sputum eosinophils, but FEV1 was more closely related to MCh-PC20 (r = 0.478, p < 0.01) than to HS-PD15 (r = 0.278, p < 0.05), and sputum eosinophils were more closely related to HS-PD15 (r = -0.324, p < 0.01) than to MCh-PC20 (r = -0.317, p < 0.05). Moreover, the @entity225 level (r = 0.285, p < 0.05) and @entity379 / @entity225 ratio (r = 0.293, p < 0.05) in sputum were significantly related to HS-PD15, but not to MCh-PC20. CONCLUSION: HS-AHR may reflect allergic @entity32 more closely than MCh-AHR.
