@entity1866 and hormonal changes in XXXX workers exposed to a mixture of organic solvents in a pharmaceutical company.

@entity1 @entity172 @entity1045 @entity132 @entity548 @entity1420 @entity406 @entity3636 @entity3971 @entity1866
BACKGROUND: Chemicals are among risk factors that can affect @entity1 's reproductive system. This study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with @entity132 and hormonal changes among female workers. METHODS: Female workers of a pharmaceutical company were divided into three groups of non-exposed, lowexposed and highly-exposed to a mixture of organic solvents ( @entity406 , @entity3971 , @entity1045 , and @entity3636 ) based on workplace measurements. @entity1866 (in terms of short cycles, long cycles, irregular cycles, and @entity548 or spotting between periods) and mean of hormone levels (including follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, prolactin, @entity172 and @entity1420 levels) were compared between these three groups. For investigating associations, logistic regression was performed. RESULTS: Our study showed that mean length of cycles, duration of @entity548 , and amount of flow and also prevalence of long cycles, irregular cycles, and @entity548 or spotting between periods were higher in exposed groups (p <=0.05). Odds ratio for prevalence of @entity1866 in the low exposure group and high exposure group were 9.69 (p=0.001) and 3.40 (p=0.002) respectively compared to the reference group. @entity172 and @entity1420 levels were not affected (p> 0.05), but other hormones levels were significantly disturbed in the exposed groups compared with the non-exposed group (p=0.001). CONCLUSION: Occupational exposure to the mixture of organic solvents may be associated with the increase of @entity1866 and hormonal changes in female workers. Based on our findings, periodic evaluation of reproductive system of female workers in pharmaceutical companies is recommended.
