The Value of Proton Magnetic Resonance Spectroscopy in High-Intensity Focused Ultrasound Treatment of Experimental XXXX .

@entity41 @entity96 @entity5 @entity39 @entity95 @entity1877 @entity435
High-intensity focused ultrasound (HIFU) is a rapidly developing, non-invasive technique for local treatment of solid @entity5 that produce coagulative @entity5 @entity39 . This study is aimed to investigate the feasibility of proton magnetic resonance spectroscopy (MRS) on early assessing treatment of HIFU ablation in @entity95 with VX2 @entity96 . HIFU ablation was performed on normal liver and VX2 @entity5 in @entity95 , and MRS was performed on normal liver and VX2 @entity5 before and 2 days after 100% HIFU ablation or 80% ablation in @entity5 volume. @entity1877 ( @entity435 ) and @entity1877 /lipid ( @entity435 /Lip) ratios between complete and partial HIFU ablation of @entity5 were compared. Tissues were harvested and sequentially sliced to confirm the @entity39 . In normal liver, the @entity435 value liver was not obviously changed after HIFU (P > .05), but the @entity435 /Lip ratio was decreased (P < .05). @entity435 in liver VX2 @entity5 was much higher than that in normal liver (P < .001). @entity435 and @entity435 /Lip ratio were significantly decreased in @entity5 after complete HIFU ablation and partial HIFU ablation, and the @entity435 value in complete HIFU @entity5 ablation did not show any difference from that in normal liver after HIFU (P > .05); however, the @entity435 value in partial ablation was still higher than that in normal liver before or in @entity5 after complete HIFU treatment due to the residual part of @entity5 , and @entity435 /Lip ratio is lower than that in complete HIFU treatment (P < .001). The changes in MRS parameters were consistent with histopathologic changes of the @entity5 tissues after treatment. MRS could differentiate the complete @entity5 @entity39 from @entity41 tissue, when combined with magnetic resonance imaging. We conclude that MRS may be applied as an important, non-invasive biomarker for monitoring the thoroughness of HIFU ablation.
