ASSOCIATION OF THE XXXX SNP @entity44305 WITH SYSTEMIC SCLEROSIS IN HAN CHINESE.

@entity1 @entity44305 @entity3794 @entity74 @entity22367 @entity785
@entity785 ( @entity785 ) is a complex disease involving @entity74 . An association of the @entity22367 polymorphism with @entity785 was reported in Caucasian populations of Europe and North America, as well as in Japanese populations. The present study aimed to examine whether the @entity785 -associated SNP @entity44305 of @entity22367 gene confer susceptibility to @entity785 and clinical features of @entity785 in a Han Chinese population. A Han Chinese cohort consisting of 424 @entity785 @entity1 and 502 healthy controls were examined in the study. TaqMan assays were carried out to examine the SNP. Exact p-values were obtained (Fisher  s test) from 2x2 tables of allele counts and disease status. @entity785 @entity1 of Han Chinese showed increased homozygous TT genotype of the @entity44305 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with @entity3794 of @entity785 and ATA-positive @entity785 of Han Chinese. The lcSSc and ACA-positive @entity785 of Han Chinese appeared also in association with the increased T allele frequency. However, the Chinese dcSSc did not show any association with the @entity44305 . The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of @entity22367 may play an important role in susceptibility to @entity785 .
