Photodynamic therapy in XXXX .

@entity355 @entity1372 @entity189 @entity850 @entity6349 @entity1141
Photodynamic therapy (PDT) was one of the earliest ablative techniques applied to @entity355 . The rationale for this use was the ability to treat large amounts of esophageal mucosa in a single rapid application. Additionally, PDT has the ability to treat @entity189 and @entity6349 tissue. Because a small @entity189 in @entity355 cannot not be excluded, PDT therapy is a reasonable treatment in this setting. The treatment involves the use of a light and drug combination that must be administered with close attention to dosimetry, since tissue effects of the therapy are delayed and cannot be observed at the time of treatment. Drug administration of @entity1372 porfimer should precede photoradiation by 48 hours. Overall results with this treatment have been good. Case series have established a success rate of 88% to 100% in elimination of high-grade @entity1141 . The only randomized multi-center prospective trial in the treatment of @entity355 with high-grade @entity1141 has established that the treatment eliminates high-grade @entity1141 better than administration of proton pump inhibitors alone. Unfortunately, there are significant adverse events, including cutaneous photosensitivity, odynophagia, @entity850 formation, and lack of response.
