XXXX given intraoperatively reduces @entity190 after total knee replacement: a randomized, controlled study.

@entity190 @entity1 @entity928 @entity927
BACKGROUND: Extensive @entity190 in total knee replacement (TKR) surgery is well known and is associated with a high transfusion rate of allogenic blood. @entity927 ( @entity928 ) has been shown to reduce @entity190 by 50% in this @entity1 group, but only in cases with a perioperative loss of 1400-1800 ml. This study was performed to see if @entity928 offers any advantages in knee replacement surgery with @entity190 at 800 ml. METHODS: Thirty consecutive @entity1 scheduled for TKR in spinal anesthesia with the use of a tourniquet, were randomized to @entity928 or non- @entity928 . @entity927 10 mg kg-1 was given at conclusion of surgery and again 3 h later. @entity190 was registered. RESULTS: @entity190 was at all times significantly lower in the @entity928 group compared to the non- @entity928 group (409.7+/-174.9 ml vs. 761.7+/-313.1 ml; P<0.001). There were no differences in coagulation parameters. No @entity1 in the @entity928 group had a blood transfusion vs. 13% in the non- @entity928 group (NS). No complications were registered in the two groups. CONCLUSION: We conclude that @entity928 significantly reduces @entity190 after total knee replacement surgery.
