Intraperitoneal nutritional support: initial results in a XXXX model.

@entity3534 @entity1568 @entity235 @entity1674 @entity412 @entity3689 @entity413
To evaluate the capacity of the peritoneal membrane to efficiently absorb complex nutritional solutions, five adult mongrel @entity235 were prepared with peritoneal and intravenous catheters. In duplicate studies each @entity235 's peritoneal catheter was rapidly infused with 1 liter of fluid containing 1.25% @entity413 , 5% fat emulsion, 2.5% mixed @entity3534 , and 20 ml of standard electrolyte additive solution. Plasma and peritoneal fluid nutrient and electrolyte concentrations and osmolarities were measured initially, 1/2 hr, and hourly for 5 hr after infusion. Mean peritoneal fluid volume increase was 56 +/- 45 ml at 5 hr (P less than 0.05). Plasma osmolarity remained unchanged as peritoneal fluid osmolarity rapidly declined to plasma level over the initial 2 hr. Peritoneal fluid concentrations of @entity413 , @entity1674 , and @entity3534 all fell precipitously during the first hour (P less than 0.01) while plasma concentrations rose in reciprocal fashion (P less than 0.01). Maximal rises above basal plasma concentrations all occurred at 1/2 hr and amounted to 42.7% for @entity413 , 39.7% for @entity1674 , and 113.2% for @entity3534 . Levels returned to normal or near normal by 5 hr. Net absorption of @entity413 was 91.7% of the total @entity413 load after 5 hr of intraperitoneal dwell time. @entity412 absorption was 65.1% and @entity3689 absorption was 91.9%. Greater than 75% of total nutrient absorption occurred during the initial hour of dwell. It is estimated that both nonprotein energy and @entity1568 requirements could be met with two to three intraperitoneal nutrient solution exchanges per day. Thus, provision of total nutritional needs may be possible with an intraperitoneal support system.
