XXXX : a clinicopathological study of 76 cases.

@entity1 @entity5 @entity979
PURPOSE: The aim of this study was to identify factors that could lead to optimization of the management of @entity979 ( @entity979 ) which remains equivocal and controversial. METHODS AND MATERIALS: In order to determine factors that influence @entity979 prognosis, a series of 76 consecutive @entity1 from 12 European centers with histologically proven @entity5 was retrospectively reviewed. The clinical records and material for histologic review were available in all cases. Follow-up was achieved in 90% of cases. RESULTS: According to WHO classification, there were 19 @entity979 , 28 intermediate and mixed @entity979 , and 29 @entity979 . According to a four-grade institutional classification, there were 11 Grade 1, 27 Grade 2, 20 Grade 3, and 18 Grade 4. Surgical resection was attempted in 44 @entity1 , whereas 30 had biopsy only. In one case, diagnosis was made at autopsy and in another on spinal deposits. Forty-four @entity1 were irradiated following surgery, 15 @entity1 received chemotherapy. Forty-one @entity1 were alive (median follow-up: 85 months); 9 @entity1 died perioperatively; 26 @entity1 relapsed. Univariate analysis showed a good outcome correlated with age above 20 years, @entity5 diameter less than 25 mm, and low-grade histology. Multivariate analysis confirmed histology and @entity5 volume to be significant independent prognostic factors. The extent of surgery and radiotherapy had no clear influence on survival. CONCLUSIONS: This review highlights the prognostic features of @entity979 and may help to determine treatment strategies based on radiologic and pathologic characteristics.
