Combination therapy of XXXX with interferon alpha-2a and photochemotherapy.

@entity1 @entity978 @entity784
The efficacy of a combination treatment with interferon alpha-2a and photochemotherapy was investigated in 16 @entity1 with @entity784 . During the initial treatment, interferon alpha-2a was given subcutaneously at maximum dose of 9 million IU. Simultaneously, photo-chemotherapy with a maximum single dose of 3.0 J/cm2 was applied. After a complete or partial remission had been achieved, the dose of interferon was continued as permanent treatment at 3-9 million IU a week. Photochemotherapy was maintained twice a week for a minimum of 2 months and then stopped depending on the course of the disease. The combination treatment was well tolerated and all @entity1 responded to the initial therapy. Three @entity1 were withdrawn at an early stage of therapy, as they developed erythrodermia after photochemotherapy. The permanent treatment led to a complete remission in ten out of 13 @entity1 and to a partial remission in three @entity1 . During the follow-up period (now 10-40 months), therapy was stopped in four @entity1 because of progression and in one @entity1 because of newly diagnosed @entity978 . In another three @entity1 , who developed local recurrences, a repetition of the initial treatment schedule was necessary to keep them in remission.
