3D.04: BLUNTED NIGHTLY BLOOD PRESSURE REDUCTION IS ASSOCIATED WITH INCREASED ARTERIAL STIFFNESS IN ISCHEMIC STROKE XXXX : A NORWEGIAN STROKE IN THE YOUNG STUDY.

@entity1 @entity64 @entity101 @entity6 @entity3257 @entity1011 @entity551 @entity122 @entity385
OBJECTIVE: Lack of nightly blood pressure (BP) reduction is associated with increased cardiovascular risk. The aim of this study was to assess the association of @entity551 with arterial stiffness in young and middle-aged @entity385 @entity1 .(Figure is included in full-text article.) DESIGN AND METHOD:: Clinic and ambulatory BP measurements were performed 3  1 month after the @entity64 in 261 @entity1 (aged 15-60 years) included in the prospective Norwegian @entity64 in the Young Study. The percent reduction in nocturnal BP was calculated from mean BP and defined as dipping if>=10%. Arterial stiffness was derived from carotid-femoral pulse wave velocity ( @entity122 ) using applanation tonometry with a Sphygmocor device. RESULTS: @entity3257 pattern was found in 38%. @entity3257 @entity1 had higher @entity122 (8.2  2.2 vs. 7.5  1.7m/s) and lower renal function, and included more @entity1 with @entity101 (51 vs. 26%) or @entity6 (16 vs. 8%, all p<0.05). Furthermore, 26% of the non-dippers had high for age @entity122 , reflecting early arterial stiffening. Age, anthropometric variables and the level of serum lipids did not differ significantly between the groups. In multivariate logistic regression analysis, non-dipping BP pattern was associated with high for age @entity122 (OR 2.22 [95% CI 1.05-4.70], p<0.05) independent of higher @entity1011 , known @entity101 , mean day BP or @entity6 (Table 1). In multivariate linear regression analysis, non-dipping pattern was also associated with higher @entity122 (Beta=0.18, p=0.01). CONCLUSIONS: In the Norwegian @entity64 in the Young Study, blunted @entity551 was common and associated with premature arterial stiffness.
