Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in XXXX .

@entity3825 @entity9808 @entity158 @entity35 @entity1509
UNASSIGNED: The rodent anterior cingulate cortex (ACC) is critical for @entity3825 and @entity158 -related aversive response in chronic visceral hypersensitive (VH) state. Long-term potentiation (LTP), induced by @entity9808 ( @entity9808 ) in the medial thalamus (MT)-ACC pathway, is blocked in VH @entity35 . However, the neuronal intrinsic firing characteristics and the MT-ACC connectivity have not been investigated in @entity3825 . Using repetitive distension of the colon and rectum (rCRD) as a sensitization paradigm, we have identified that the spontaneous firing rates of ACC neurons and the @entity1509 -stimulated neuronal firings were increased after repetitive visceral noxious stimulation. This correlates with @entity3825 responses (visceromotor responses, VMRs). Two multichannel arrays of electrodes were implanted in the MT and ACC. Recordings were performed in free-moving @entity35 before and after repeated @entity1509 treatment. Power spectral density analysis showed that the local field potential (LFP) recorded in the ACC displayed increases in theta band power (4-10Hz) that were modulated by rCRD. Neural spike activity in the ACC becomes synchronized with ongoing theta oscillations of LFP. Furthermore, cross correlation analysis showed augmented synchronization of thalamo-ACC theta band LFPs, which was consistent with an increase of neuronal communication between the two regions. In conclusion, these results reveal theta oscillations and theta-frequency phase-locking as prominent features of neural activity in the ACC and a candidate neural mechanism underlying acute @entity3825 .
