XXXX and creativity: mechanisms and treatment risks.

@entity1 @entity162 @entity308 @entity75 @entity167 @entity935 @entity2438 @entity191 @entity1091 @entity1245 @entity1315 @entity716 @entity750 @entity4943 @entity752 @entity1063
@entity75 and their treatment may help or hurt creativity in ways that shape quality of life. Increased creative drive is associated with @entity162 , @entity308 , @entity716 , @entity1315 , @entity4943 , @entity191 treatments, and @entity2438 . Creativity depends on goal-driven approach motivation from midbrain dopaminergic systems. Fear-driven avoidance motivation is of less aid to creativity. When @entity750 and @entity1063 lower motivation and flexible behaviour, they can inhibit creativity. Hemispheric lateralization and frontotemporal connections must interact to create new ideas and conceptual schemes. The right brain and temporal lobe contribute skill in novelty detection, while the left @entity75 and more easily generate new patterns of action from the novel perceptions. Genes and phenotypes that increase plasticity and creativity in tolerant environments with relaxed selection pressure may confer risk in rigorous environments. Few papers substantively address this important but fraught topic. Antidepressants (ADs) that inhibit fear-driven motivation, such as selective @entity750 reuptake inhibitors, sometimes inhibit goal-oriented motivation as well. ADs that boost goal-directed motivation, such as @entity752 , may remediate this effect. @entity1245 and @entity167 may be counterproductive. Although dopaminergic agonists sometimes stimulate creativity, their doing so may inappropriately disinhibit behaviour. @entity935 antagonists may suppress creative motivation; @entity1091 and anticonvulsant mood stabilizers may do so less. Physical exercise and REM sleep may help creativity. Art therapy and psychotherapy are not well studied. Preserving creative motivation can help creativity and other aspects of well-being in all @entity1 , not just artists or researchers.
