Glycogen depletion and XXXX and responsiveness in muscle after exercise.

@entity13080 @entity19037 @entity101 @entity35 @entity1720 @entity413
As judged by its ability to stimulate @entity413 uptake and @entity13080 ( @entity19037 ) transport, the sensitivity and the responsiveness of perfused @entity35 muscle to insulin are enhanced after moderately intense treadmill exercise. In fed @entity35 , these enhanced effects of insulin are predominantly restricted to muscles that performed work as evidenced by glycogen depletion. The present study was designed to examine the relationship between glycogen depletion per se and the postexercise changes in insulin action. Toward this end, fed and 48-h starved @entity35 were run on a treadmill for 45 min at moderate intensity, and @entity413 and @entity19037 uptake were then assessed using the isolated perfused hindquarter preparation. Glycogen is depleted in red muscles such as the soleus and red fibers of the gastrocnemius in fed @entity35 immediately after such exercise, whereas, in starved @entity35 , muscle glycogen is unchanged. As previously shown, the stimulation by insulin of @entity413 utilization by the hindquarter and @entity19037 transport into red muscles was substantially increased in fed @entity35 after the treadmill run. This was due to @entity1720 and responsiveness. In starved @entity35 , the treadmill run also enhanced the ability of insulin to stimulate these processes; however, this was solely due to an @entity1720 . No change in insulin responsiveness was observed. The results indicate that the enhanced sensitivity of muscle to insulin after exercise is not dependent on glycogen depletion, whereas @entity101 not occur in its absence. They also suggest that the mechanisms by which prior exercise acts to @entity1720 and responsiveness are different.
