No evidence of association between subclinical XXXX and common carotid intima medial thickness or @entity731 plaque.

@entity1 @entity1375 @entity101 @entity6 @entity1955 @entity2998 @entity1378 @entity74 @entity731 @entity543 @entity121 @entity65 @entity165 @entity1374
BACKGROUND AND AIMS: Increased carotid artery @entity121 ( @entity121 ) and the presence of plaques have been shown to be predictors of @entity65 . The cardiovascular risk in @entity1 with overt @entity1374 is related to increased risk of @entity731 , but there has been no clear evidence about @entity74 . We have assessed whether subclinical @entity1374 is associated with arterial thickening and plaque. METHODS AND RESULTS: The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14-102 years), none of whom had overt @entity1378 or @entity1375 or was taking thyroid medication. Serum thyrotropin (TSH), free @entity1955 , together with carotid ultrasound @entity121 and the presence of common carotid plaques were analysed in all subjects. Possible association of @entity121 and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. @entity121 was significantly associated with age, sex, smoking, low density lipoprotein @entity165 (LDL), high density lipoprotein @entity165 , pulse pressure (PP), history of arterial @entity101 , @entity6 , and previous @entity65 (p  =  0.001 or lower, R(2)  =  0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of @entity6 , previous @entity65 , and the use of statins (p  =  0.029 or lower). Thyroid hormone was not predictive of @entity2998 when adjusted for confounders. CONCLUSION: Thyroid hormone is not associated with increased @entity121 or with the presence of @entity543 . Our data do not support the idea that treating @entity74 might help to prevent arterial remodelling or @entity2998 .
