XXXX in a rural Wisconsin population from 1992 to 2008: narrowing of the male-to-female ratio.

@entity1 @entity1791
PURPOSE: @entity1791 is a common disease with multiple etiologies and risk factors. Studies suggest an increased incidence in developed nations in recent decades as well as differential geographic incidence and prevalence rates, and differences between the genders. We updated @entity1791 epidemiological data by examining the incidence and prevalence rates in a stable rural Wisconsin population. MATERIALS AND METHODS: Data were obtained from the Marshfield Epidemiologic Study Area database, a surveillance tool created in 1991 to track disease in residents of an area of 24 ZIP Codes including approximately 85,000 individuals, of whom most receive care at Marshfield Clinic and affiliates. @entity1791 cases were identified using ICD-9 codes. Incidence, prevalence and recurrence rates were determined. RESULTS: The mean age adjusted incidence of new onset @entity1791 per 100,000 @entity1 -years was 202 (95% CL 168-235) in 1992 and 289 (95% CL 253-325) in 2008. In @entity1 the increase per 100,000 @entity1 -years was higher than in @entity1 , that is 171 (95% CL 129-213) and 289 (95% CL 238-340) vs 238 (95% CL 184-290) and 296 (95% CL 244-348), respectively. The male-to-female incidence ratio decreased from 1.4 to 1.0. The age adjusted prevalence per 100,000 individuals was 1,968 (2%) and 3,554 (3.5%) in 1992 and 2008, respectively. The increase in @entity1 was higher than in @entity1 (52% vs 26%). The age adjusted recurrence rate per 100,000 individuals was 553 (0.72%) and 676 (1.0%) in 1992 and 2008, respectively. The increase in @entity1 was higher than in @entity1 (88% vs 20%). CONCLUSIONS: Since 1992, @entity1791 incidence, prevalence and recurrence rates in this rural Wisconsin population have increased with higher increases noted in @entity1 . While prevalence increased, it was lower than reported in other geographic areas in the United States.
