Genetic aberrations common in gastric high-grade large XXXX .

@entity1 @entity124 @entity706 @entity986 @entity5 @entity9288 @entity11626 @entity876 @entity4042 @entity1892 @entity74
Genetic aberrations associated with the development of extranodal high-grade large @entity1892 originating in the stomach have not been fully identified yet. We analyzed 31 such @entity706 using 73 microsatellite markers for @entity74 and @entity124 . The highest frequency (42%) of loss of heterozygosity (LOH) was found on the long arm of chromosome 6. We identified 2 LOH hot spots on 6q21-22.1 and 6q23.3-25, flanked by markers D6S246-D6S261 and D6S310-D6S441, respectively, containing putative @entity5 ( @entity5 ). These 6q aberrations were found to be the sole @entity74 in 1 @entity1 only; they were mostly accompanied by additional abnormalities. Several known @entity5 , namely, the APC, @entity9288 / @entity986 , @entity876 , and DCC genes, were found to suffer frequent LOH during lymphomagenesis. LOH was also detected in regions containing putative @entity5 on 7q and 13q14. Frequent amplification of genomic material was found in the 2p, 3q27 at the @entity4042 gene locus, 6p, 7q, 11q23-24 at the @entity11626 gene locus, and 18q regions. Analysis of the pattern of occurrence of these aberrations revealed an association of the amplification of the @entity11626 gene region with LOH at the @entity876 locus (P =.02). Only low frequency of @entity124 ( @entity124 ) was detected in these @entity706 and @entity124 incidence increased with age (P =.01). Karyotypic instability thus plays the main role in the development of gastric high-grade large @entity1892 . Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of @entity876 , and amplification of the 3q27 and the @entity11626 gene regions. (Blood. 2000;95:1180-1187)
