Confocal laser endomicroscopy: a novel method for prediction of relapse in XXXX .

@entity1 @entity31 @entity30 @entity941
UNASSIGNED: Background and study aims: Confocal laser endomicroscopy (CLE) has been shown to predict relapse in @entity31 in remission, but little is currently known about its role in @entity30 . The aim of this study was to identify reproducible CLE features in @entity1 with @entity30 and to examine whether these are risk factors for relapse. @entity1 and methods: This was a single-center prospective feasibility study of CLE imaging in @entity1 with @entity30 . CLE imaging was performed in the terminal ileum and four colorectal sites, and was correlated with histopathology and macroscopic appearance. Clinical relapse, defined as the need for treatment escalation or surgical intervention, was recorded during follow-up. Results: The study included 50 @entity1 : 39 with @entity30 (20 in remission), and 11 controls. Ileal @entity941 leakage and microerosions were significantly more frequent in @entity1 with endoscopically active @entity30 compared with @entity1 with inactive @entity30 and controls (P=0.005 and (P=0.006, respectively). The same applied to colorectal @entity941 leakage and vascular alterations ((P=0.043 and (P=0.034, respectively). During a 12-month follow-up period, ileal @entity941 leakage and microerosions were significant risk factors for relapse in the subgroup of @entity1 in remission (log rank (P=0.009 and (P=0.007, respectively) as well as in the entire group of @entity1 with @entity30 (log rank (P=0.006 and (P=0.01, respectively). Inter- and intraobserver reproducibility was almost perfect (k>0.80) or substantial (k>0.60) for the majority of CLE parameters. Conclusions: CLE can identify reproducible microscopic changes in the terminal ileum that are risk factors for relapse in @entity1 with otherwise inactive @entity30 . TRIAL REGISTRATION: ClinicalTrials.gov (NCT01738529).
