Aggressive surgical resection for hilar-invasive and peripheral XXXX .

@entity1 @entity1263 @entity1419 @entity3
The clinicopathology and surgical outcome of @entity1419 are not fully understood. The objective of this study was to clarify the clinicopathologic features of @entity1419 and evaluate prognostic factors influencing survival. Forty consecutive @entity1 with @entity1419 undergoing surgical resection at Chiba University Hospital between October 1981 and October 1997 were analyzed retrospectively. @entity1419 were classified as hilar-invasive type ( n = 26) or peripheral type ( n = 14). @entity1 with @entity1263 had a significantly ( p = 0.005) better 5-year survival rate (43%) than those with the hilar-invasive type (4%). @entity3 had perineural invasion (100%) and nodal involvement (85%) more frequently than did @entity1263 . Despite aggressive surgical resection, the surgical margin was positive in 88% of @entity1 with @entity3 (23/26) and 29% of @entity1 with @entity1263 (4/14). There was no evidence of a survival benefit of vascular resection for @entity1 with a hilar-invasive @entity1419 . @entity1 with lymph node @entity3 had a significantly worse prognosis ( p = 0.0004). No @entity1 with nodal involvement survived more than 38 months. Negative perineural invasion ( p = 0.008) and a negative microscopic margin ( p = 0.008) were significantly associated with improved survival. Better survival results could be achieved by curative resection with a free margin for hilar-invasive and peripheral @entity1419 .
