Clinical and echocardiographic characteristics for differentiating between @entity20117 -related and light-chain XXXX .

@entity1 @entity2783 @entity67 @entity3876 @entity299 @entity20117 @entity2015
Differential diagnosis between @entity20117 ( @entity20117 ) @entity2015 ( @entity2015 ) @entity299 is essential due to significantly different prognoses and therapeutic options. Therefore, clinical characteristics of @entity1 with biopsy-proven @entity299 were investigated to differentiate @entity20117 from @entity2783 . From September 2006 to May 2014, 46 @entity1 were confirmed to have @entity299 ( @entity20117 , n   =   28; @entity2015 , n   =   18) in our institute. The median age of @entity1 with @entity20117 @entity2783 was 78  years (range 61-90) with 27 (96  %) males, while that of @entity1 with @entity2783 was 66 (range 52-76) with 12 (67  %) males. There were no statistically significant differences in echocardiographic findings regarding left ventricular (LV) systolic function or @entity67 between the two groups. Interestingly, serum @entity3876 ( @entity3876 ) levels in @entity1 with @entity2783 were significantly higher than those in @entity20117 @entity2783 @entity1 . In contrast, the LV wall was significantly thicker in @entity1 with @entity20117 @entity2783 than in those with @entity2783 . Therefore, the ratio of @entity3876 to LV mass index (LVMI) at presentation in @entity2783 @entity1 was significantly higher than that in @entity20117 @entity1 (6.7 vs 2.9, p   =   0.0006). A @entity3876 -LVMI ratio of less than 3.5 had a diagnostic sensitivity and specificity for @entity20117 @entity2783 of 71 and 83  %, respectively. One-year overall survival was 88.7  % in the @entity1 with @entity20117 @entity2783 and 23.7  % in the @entity1 with @entity2783 . Our analysis indicates that the @entity3876 -LVMI ratio, as well as age and sex, may be useful parameters for distinguishing @entity20117 from @entity299 .
