Subsequent mortality after XXXX crisis episode in the non-elderly: a national population-based cohort study.

@entity1 @entity64 @entity2749 @entity712 @entity6 @entity5 @entity409 @entity1030 @entity1602
UNASSIGNED: @entity2749 ( @entity2749 )- @entity6 and the @entity1602 state-are the most serious acute metabolic complications of @entity6 . We aimed to investigate the subsequent mortality after HCE in the non-elderly @entity6 which is still unclear. This retrospective national population-based cohort study reviewed, in Taiwan's National Health Insurance Research Database, data from 23,079 non-elder @entity1 ( <=65  years) with new-onset @entity6 between 2000 and 2002: 7693 @entity1 with HCE and 15,386 @entity1 without HCE (1:2). Both groups were compared, and follow-up prognoses were done until 2011. One thousand eighty-five (14.1  %) @entity1 with HCE and 725 (4.71  %) @entity1 without HCE died (P  <  0.0001) during follow-up. Incidence rate ratios (IRR) of mortality were 3.24 times higher in @entity1 with HCE than in @entity1 without HCE (P  <  0.0001). Individual analysis of @entity6 and @entity1602 state also showed the similar result with combination of both. After stratification by age, mortality was significant higher in the middle age (40-64  years) [IRR 3.29; 95  % confidence interval (CI) 2.98-3.64] and young adult (18-39  years) (IRR 3.91; 95  % CI 3.28-4.66), but not in the pediatric subgroup (<18  years) (IRR 1.28; 95  % CI 0.21-7.64). The mortality risk was highest in the first month (IRR 54.43; 95  % CI 27.98-105.89), and still high after 8  years (IRR 2.05; 95  % CI 1.55-2.71). After adjusting for age, gender, and selected comorbidities, the mortality hazard ratio for @entity1 with HCE was still four times higher than for @entity1 without HCE. Moreover, older age, male gender, @entity64 , @entity5 , @entity1030 , @entity712 , and @entity409 were independent mortality predictors. HCE significantly increases the subsequent mortality risk in the non-elderly with @entity6 . Strategies for prevention and control of comorbidities are needed as soon as possible.
