Longitudinal Change in Mammographic Density among ER-Positive @entity0 XXXX Using @entity440 .

@entity1 @entity172 @entity0 @entity440 @entity14220
UNASSIGNED: @entity440 -associated @entity14220 ( @entity14220 ) reductions are linked to improved @entity0 survival. We evaluated @entity14220 at six time points to determine the timing of greatest reduction following @entity440 initiation. We sampled 40 Kaiser Permanente Northwest @entity172 receptor (ER)-positive @entity0 @entity1 from a prior study of @entity14220 change, according to @entity440 use duration and age at diagnosis: <4 years @entity440 and  <=50 years (N = 6) or >50 years (N = 10) old; >= 4 years @entity440 and  <=50 years (N = 13) or >50 years (N = 11) old. A single reader evaluated percent @entity14220 in the contralateral breast on baseline (pre-diagnosis) and five approximately yearly post-diagnostic (T1 to T5) mammograms. Mean @entity14220 change was calculated. Interactions with age ( <=50 and >50 years), @entity440 duration (<4 and >= 4 years), and baseline @entity14220 (tertiles) were tested in linear regression models. Overall, the largest @entity14220 decline occurred by T1 (mean 4.5%) with little additional decline by T5. Declines differed by tertile of baseline @entity14220 (P interaction < 0.01). In the highest tertile, the largest reduction occurred by T1 (mean 14.9%), with an additional reduction of 3.6% by T5. Changes were smaller in the middle and lowest baseline @entity14220 tertiles, with cumulative reductions of 3.0% and 0.4% from baseline to T5, respectively. There were no differences by age (P interaction = 0.36) or @entity440 duration (P interaction = 0.42). Among ER-positive @entity1 treated with @entity440 and surviving >= 5 years, most of the @entity14220 reduction occurred within approximately 12 months of @entity440 initiation, suggesting that @entity14220 measurement at a single time point following @entity440 initiation can identify @entity1 with substantial density declines. Cancer Epidemiol Biomarkers Prev; 25(1); 1-5.   2015 AACR.
