Lipid metabolic effect of Korean red @entity9052 extract in XXXX fed on a high-fat diet.

@entity28 @entity19 @entity13885 @entity3857 @entity1674 @entity9052 @entity413 @entity165
BACKGROUND: @entity9052 @entity3857 and @entity13885 exert anti- @entity28 effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti- @entity28 effects of @entity9052 and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti- @entity28 effects of Korean red @entity9052 extract (KRGE) and hepatic gene expression profiles in @entity19 fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of @entity165 , low-density lipoprotein- @entity165 (LDL-C), serum @entity1674 , and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate @entity413 and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down-regulate genes associated with lipid metabolism or @entity165 metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up-regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing @entity28 .
