XXXX genes have different expression patterns in healthy and diseased upper airway mucosa.

@entity480 @entity1 @entity1127 @entity5090 @entity565 @entity26080 @entity5091 @entity26484 @entity5089 @entity3558 @entity2355 @entity21826 @entity5088 @entity1577
BACKGROUND: Mucus hyper-secretion is a feature of several airways diseases such as chronic rhinosinusitis, @entity565 , and @entity1577 ( @entity1577 ). Since mucins are major components of mucus, the knowledge of their distribution and regulation in nasal tissues is likely to improve mucus hyper-secretion therapy. OBJECTIVE: The aim of this study was to evaluate and compare @entity3558 gene expression at epithelial and glandular levels, and to identify potential @entity3558 expression patterns for specific upper airways pathologies. METHODS: Immunohistochemistry for @entity2355 , @entity5091 , and @entity5088 - @entity26080 mucins was performed on healthy nasal mucosa (NM; n=12), bilateral @entity480 ( @entity480 ; n=38), @entity480 from @entity1577 @entity1 (n=10), and antrochoanal (AC) @entity1127 (n=11). @entity5091 , @entity5088 , @entity5089 , and @entity21826 mRNA expression were also analysed by in situ hybridization. RESULTS: @entity2355 , @entity5088 , and @entity5089 mucins were highly expressed in the epithelium and their expression pattern was similar in all @entity480 types, @entity2355 and @entity5088 being increased and @entity5089 decreased compared with NM. @entity26080 was highly detected at both epithelial and glandular levels with marked variability between groups. @entity5090 was mainly detected in glands and the expression in all polyp types was higher than in NM. Moreover, @entity5090 expression was higher in @entity480 epithelia from @entity1577 @entity1 than in bilateral @entity480 and healthy NM. Although @entity5091 expression was low, especially in AC @entity1127 , it was detected in most samples. In NM, @entity21826 and @entity26484 were scarcely detected and @entity26484 expression was restricted to glands. CONCLUSIONS: These results suggest that @entity480 have a different pattern of @entity3558 expression than healthy NM and that @entity1127 (increased @entity5090 ) and AC @entity1127 (decreased @entity5091 ) have a different @entity3558 expression pattern than bilateral @entity480 .
