XXXX virus: pathogenesis, immune responses, potential prevention.

@entity1 @entity2598 @entity548 @entity7593 @entity1003 @entity881 @entity204
UNASSIGNED: Ebola zoonotic RNA filovirus represents @entity1 most virulent and lethal pathogens, which induces @entity7593 and @entity204 within few days in a range of 60-90% of symptomatic individuals. Last outbreak in 2014 in West Africa caused panic that @entity2598 can be spread to other continents. Number of deaths in late December reached almost 8,000 individuals out of more than 20,000 symptomatic @entity1 . It seems that only a coordinated international response could counteract the further spread of Ebola. Major innate immunity mechanisms against Ebola are associated with the production of interferons, that are inhibited by viral proteins. Activation of host NK cells was recognized as a leading immune function responsible for recovery of infected @entity1 . Uncontrolled cell infection by Ebola leads to an impairment of immunity with cytokine storm, @entity1003 , @entity548 , @entity881 and @entity204 . Tested prevention strategies to induce antiviral immunity include: i. recombinant virus formulations (vaccines); ii. cocktail of monoclonal antibodies (serotherapy); iii. alternative RNA-interference-based antiviral methods. Maintaining the highest standards of aseptic and antiseptic precautions is equally important. Present brief review summarizes a current knowledge concerning pathogenesis of @entity548 and the virus interaction with the immune system and discusses recent advances in prevention of @entity2598 by vaccination and serotherapy.
