XXXX does not influence @entity1636 during @entity4053 in @entity1 .

@entity1 @entity4089 @entity4545 @entity627 @entity1425 @entity4090 @entity4053 @entity1636 @entity701 @entity2211 @entity1063 @entity413
Elevated plasma @entity4090 and mild hypocortisolemia have been observed in @entity1 with @entity627 . This study was designed to assess the potential inhibitory effect of @entity4089 on @entity1636 . @entity4053 was induced by intravenous insulin injection (0.1 IU/kg) in 10 female volunteers of fertile age during their follicular phase twice: 60 min after either @entity2211 (10 mg orally) or placebo administration. Blood samples were collected from an indwelling catheter inserted into the cubital vein at -60, 0, 30, 45, 60 and 90 min. The concentrations of @entity4090 , @entity4545 ( @entity4545 ), @entity701 , @entity1425 , @entity1063 and @entity413 were measured in plasma. @entity2211 administration significantly increased plasma @entity4090 concentrations (71 +/- 11 ng/ml vs. 14 +/- 6 ng/ml; p <0.001), while basal plasma concentrations of @entity4545 , @entity701 , @entity1063 and @entity1425 were unaffected. Insulin-induced @entity4053 resulted in a significant rise in the mean plasma @entity4545 levels from 10 +/- 1 pg/ml ( @entity2211 ) and 11 +/- 1 pg/ml (controls) to 148 +/- 19 pg/ml ( @entity2211 ) and 139 +/- 12 pg/ml (controls) at 45 min (p < 0.001), in plasma @entity701 from 407 +/- 62 nmol/l ( @entity2211 ) and 391 +/- 42 nmol/l (controls) to 925 +/- 60 nmol/l ( @entity2211 ) and 810 +/- 52 nmol/l (controls) at 60 min (p < 0.001), and in plasma @entity1425 from 40 +/- 26 pg/ml ( @entity2211 ) and 16 +/- 3 pg/ml (controls) to 274 +/- 55 pg/ml ( @entity2211 ) and 352 +/- 61 pg/ml (controls) at 30 min; (p < 0.001). The significant increase in @entity4545 , @entity701 and @entity1425 responses to @entity4053 was similar in both groups. We observed mild @entity1063 response to @entity4053 but this was irrespective of the medication. In conclusion, pharmacologically-induced @entity4089 did not induce significant changes of @entity1636 and did not influence sympathoadrenal activity in healthy young @entity1 .
