Multiparametric magnetic resonance in the assessment of the gender differences in a high-grade XXXX @entity35 model.

@entity1 @entity32 @entity39 @entity5 @entity4 @entity146 @entity1313 @entity11 @entity816 @entity35 @entity463
BACKGROUND: @entity463 , the most frequent and aggressive of all @entity816 , presents a clear predominance in male @entity1 , but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal model of this @entity5 by means of magnetic resonance (MR) imaging and biochemical and behavioural studies. METHODS: A high-grade @entity11 model developed in male and female @entity35 was used. Multiparametric magnetic resonance images and localized spectra were acquired. The MR parameters linked to tumoural features were quantified. Motor and metabolic activity was also assessed. Postmortem analyses were carried out to measure indicators of @entity5 and viability of the blood-brain barrier (BBB). RESULTS: Statistically significant differences dependent on the animal sex were found in the study of pathological indicators like @entity4 , @entity32 , cellularity and microvasculature. Results suggest higher cell proliferative rate, @entity32 and vasogenic @entity4 and or @entity39 in @entity11 -bearing male @entity35 . Haemodynamic parameters measured indicated a major disruption of the BBB, postmortem confirmed, in this sex. Metabolomic and energetic metabolism activity data are in agreement with a major @entity5 and @entity146 of this @entity5 model on males. CONCLUSIONS: Gender differences should be taken into account in preclinical studies of @entity463 models, in the characterization of the tumoural behaviour and consequently in the development and validation of new therapeutic approaches. MR imaging and spectroscopy allow to non-invasively monitor this sexual dimorphism in the diagnosis and prognosis of @entity1313 .
