Response of cortical metabolic deficits to serotonergic challenge in XXXX .

@entity4899 @entity1 @entity162 @entity308 @entity419 @entity1316 @entity209 @entity221 @entity413
OBJECTIVE: In subjects with @entity1316 , positron emission tomography (PET) with @entity419 has shown prefrontal cortical @entity209 , including in a subgenual region in subjects with @entity221 . The authors applied a dl- @entity4899 challenge method to study metabolic response in this region to serotonergic challenge in @entity308 . METHOD: The study group consisted of 19 @entity308 subjects with major @entity308 or @entity162 , all of whom had at least one first-degree relative with history of @entity308 , and 10 healthy volunteers with similar age and gender distributions. PET images were acquired under placebo and challenge conditions, and volumetric MRI scans were also obtained. Group comparisons of metabolic and volumetric data were performed. Ratings of acute mood change during serotonergic challenge were compared with the imaging data. RESULTS: Within Brodmann's area 32, a @entity413 metabolism deficit in the @entity308 subjects on placebo day was observed by voxel-level analysis, but no volumetric deficit was found in the subgenual regions examined. Under challenge, both groups suppressed metabolism similarly. Within the @entity1 group, the correlation between acute mood improvement during challenge and greater metabolic suppression approached significance. CONCLUSIONS: In @entity1316 , a ventromedial prefrontal cortical @entity209 is not due to altered structural volume, and the response to serotonergic challenge appears predictive of acute mood response. The potential to predict treatment response can be tested by a combined challenge and treatment study.
