Stereotactic body radiation therapy in XXXX : Optimal treatment strategies based on @entity409 .

@entity1 @entity16679 @entity82 @entity137 @entity5 @entity409 @entity157
AIM: To discuss current dosage for stereotactic body radiation therapy (SBRT) in @entity157 ( @entity157 ) @entity1 and suggest alternative treatment strategies according to @entity409 as defined by the Couinaud classification. BACKGROUND: SBRT is a safe and effective alternative treatment for @entity157 @entity1 who are unable to undergo liver ablation/resection. However, the SBRT fractionation schemes and treatment planning strategies are not well established. MATERIALS AND METHODS: In this article, the latest developments and key findings from research studies exploring the efficacy of SBRT fractionation schemes for treatment of @entity157 are reviewed. @entity1 ' characteristics, fractionation schemes, treatment outcomes and @entity137 were compiled. Special attention was focused on SBRT fractionation approaches that take into consideration @entity409 according to the Couinaud classification and functional hepatic reserve based on @entity1 -Pugh (CP) liver @entity82 classification. RESULTS: The most common SBRT fractionation schemes for @entity157 were 3  *  10-20  Gy, 4-6  *  8-10  Gy, and 10  *  5-5.5  Gy. Based on previous SBRT studies, and in consideration of @entity5 size and CP classification, we proposed 3  *  15-25  Gy for @entity1 with @entity5 size <3  cm and adequate liver reserve (CP-A score 5), 5  *  10-12  Gy for @entity1 with @entity5 sizes between 3 and 5  cm or inadequate liver reserve (CP-A score 6), and 10  *  5-5.5  Gy for @entity1 with @entity5 size >5  cm or @entity16679 score. CONCLUSIONS: Treatment schemes in SBRT for @entity157 vary according to @entity409 . Further prospective studies may be necessary to identify the optimal dose of SBRT for @entity157 .
