Gamma knife radiosurgery for @entity699 and XXXX .

@entity1 @entity5 @entity699 @entity4614 @entity652 @entity2014
PURPOSE: This paper presents our 18  years of experience in treating ACTH secreting @entity652 ( @entity699 and @entity2014 ) using the Leksell gamma knife (LGK) irradiation. METHODS: Twenty-six @entity1 with @entity699 were followed-up after LGK irradiation for 48-216  months (median 78  months). Seventeen @entity1 had undergone previous surgery, in nine @entity1 LGK irradiation was the primary therapy. Furthermore, 14 @entity1 with @entity2014 were followed-up for 30-204  months (median 144  months). RESULTS: LGK treatment resulted in hormonal normalization in 80.7  % of @entity1 with @entity699 . Time to normalization was 6-54  months (median 30  months). The volume of the @entity652 decreased in 92.3  % (in 30.7  % disappeared completely). There was no recurrence of the disease. In all 14 @entity1 with @entity2014 ACTH levels decreased (in two @entity1 fully normalized) their ACTH levels. When checked up 5-10  years after irradiation regrowth of the @entity652 was only detected in one @entity1 (9.1  %), in 27.3  % @entity652 volume remained unchanged, in 45.4  % @entity652 volume decreased and in 18.2  % @entity652 completely disappeared. @entity4614 did not develop in any @entity1 where the critical dose to the pituitary and distal infundibulum was respected. CONCLUSION: LGK radiation represents an effective and well-tolerated option for the treatment of @entity1 with @entity699 after unsuccessful surgery and may be valuable even as a primary treatment in @entity1 who are not suitable for, or refuse, surgery. In the case of @entity2014 it is possible to impede @entity5 growth and control the size of the @entity652 in almost all @entity1 .
