Short term fat feeding rapidly increases plasma XXXX but does not result in dyslipidaemia.

@entity101 @entity28 @entity95 @entity591 @entity2367 @entity8446 @entity8557 @entity413
Although the association between @entity28 and @entity101 is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in @entity95 produces greater visceral adiposity, @entity101 , @entity591 and elevated renal sympathetic nerve activity (RSNA) compared to @entity95 on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with @entity101 we compared plasma @entity8446 , leptin, and lipid profiles in male New Zealand White @entity95 fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), @entity2367 and @entity8557 (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma @entity8446 and @entity413 increased within the first 3 days of the diet in HFD @entity95 (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and @entity2367 at week 3 did not differ between groups (P > 0.05). Our data show plasma @entity8446 increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the @entity101 in this animal model.
