Apoptosis and cell proliferation in the development of @entity356 : associations with @entity517 and XXXX protein expression.

@entity1 @entity5 @entity517 @entity1977 @entity876 @entity356
BACKGROUND AND AIM: @entity1 with @entity356 have a poor prognosis and low survival rates. The aim of the present paper was to characterize cellular and molecular properties to provide insight into aspects of @entity5 progression in early compared with advanced @entity356 . METHODS: One hundred and nine graded @entity356 (early or advanced stage, undifferentiated or differentiated type) with paired non- @entity5 tissue were studied to define the correlation between apoptosis (morphology, terminal deoxyribonucleotidyl transferase-mediated @entity1977 -digoxigenin nick end-labeling), cell proliferation (Ki-67 expression, morphology) and expression and localization of two proteins frequently having altered expression in @entity5 , namely @entity876 and @entity517 . RESULTS: Overall, apoptosis was lower in early stage, differentiated and undifferentiated @entity356 compared with @entity5 . Cell proliferation was comparatively high in all stages. There was a high level of @entity876 positivity in all stages. Only the early- and @entity5 that were @entity876 positive had a significantly higher level of apoptosis (P < 0.05). Cell proliferation was significantly greater (P < 0.05) only in the early undifferentiated @entity5 that had either @entity517 or @entity876 -positivity. CONCLUSIONS: The results indicate that low apoptosis and high cell proliferation combine to drive @entity356 development. The molecular controls for high cell proliferation of the early stage undifferentiated @entity356 involve overexpression of both @entity876 and @entity517 . Overexpression of @entity876 may also control @entity5 development in that its expression is associated with higher levels of apoptosis in early and late-stage undifferentiated, @entity5 .
