XXXX in adults: results of intraventricular maintenance chemotherapy for central nervous system prophylaxis and treatment.

@entity1 @entity981 @entity693 @entity1500 @entity1499 @entity2359
The results of intraventricular (i.vt.) chemotherapy in 36 cases of adult @entity981 ( @entity981 ) were analyzed to define a useful and reliable form of central nervous system (CNS) prophylaxis. @entity1 received @entity1499 ( @entity1500 ) via an Ommaya reservoir six times every 4 weeks. This was repeated when bone marrow relapse occurred. Intraventricular maintenance CNS prophylaxis during half a year appeared adequate, since primary CNS relapses were seen in only two @entity1 (5.6%). These @entity1 had failed to follow the prophylaxis schedule. The procedure was implemented and repeated relatively easily and did not lead to @entity2359 . The i.vt. route was also satisfactory for the treatment of initial and recurrent episodes of @entity693 ( @entity693 ). The therapy reduced morbidity caused by @entity693 to a minimum.
