Association of orexin receptor polymorphisms with antipsychotic-induced XXXX .

@entity1 @entity1088 @entity36260 @entity71207 @entity71206 @entity914 @entity14610 @entity1017 @entity161 @entity1037 @entity1090
OBJECTIVES: Antipsychotic-induced @entity1017 (AIWG) is a common side effect of treatment with antipsychotics such as @entity1088 and @entity1037 . The orexin gene and its receptors are expressed in the hypothalamus and have been associated with maintenance of energy homeostasis. In this study, we have analysed tagging single nucleotide polymorphisms (SNPs) in @entity14610 ( @entity14610 and @entity36260 ) for association with AIWG. METHODS: @entity161 or @entity914 subjects (n   =   218), treated mostly with @entity1088 and @entity1037 for up to 14 weeks, were included. Replication was conducted in a subset of CATIE samples (n   =   122) treated with either @entity1037 or @entity1090 for up to 190 days. Association between SNPs and AIWG was assessed using analysis of covariance (ANCOVA) with baseline weight and duration of treatment as covariates. RESULTS: Several SNPs in @entity36260 were nominally associated with AIWG in @entity1 of European ancestry treated with either @entity1088 or @entity1037 (P<0.05). In the replication analysis two SNPs @entity71206 (P   =   0.043) and @entity71207 (P   =   0.012) were nominally associated with AIWG. None of the SNPs in @entity14610 were associated with AIWG. CONCLUSION: This study provides preliminary evidence supporting the role of @entity36260 in AIWG. However, these results need to be confirmed in large study samples.
