Significant relationships of plasma lipids and body mass index with polymorphisms at the linked XXXX gene and @entity8277 gene loci (19p13.2) in essential @entity101 @entity1 .

@entity754 @entity1 @entity101 @entity28 @entity1674 @entity8277 @entity165
1. Recent molecular genetic studies have implicated the @entity754 gene locus ( @entity754 , at chromosome 19p13.2) in @entity28 in essential @entity101 @entity1 and in the atherogenic lipoprotein phenotype. The present study examined genotypes for the @entity28 -associated ApaLI restriction fragment length polymorphism of @entity754 , and genotypes for a @entity101 -associated RsaI restriction fragment length polymorphism at the @entity8277 gene ( @entity8277 ) locus, which is linked to @entity754 , in relation to plasma lipids, body mass index and blood pressure in 27 @entity28 and 57 @entity28 Caucasians with severe essential @entity101 , selected on the basis of having parents who were both @entity101 , and in 25 @entity28 and 45 @entity28 normotensive subjects selected on the basis of having parents who were both normotensive after the age of 50 years. 2. Plasma @entity1674 and low-density-lipoprotein- @entity165 were elevated in @entity101 @entity1 , but did not differ between the @entity28 and @entity28 @entity101 groups. Significant positive correlations were seen between body mass index and @entity1674 and low-density-lipoprotein- @entity165 in the @entity28 and @entity28 @entity101 @entity1 , respectively. In addition, @entity28 @entity101 @entity1 had significantly higher diastolic blood pressure than @entity28 @entity101 @entity1 . 3. The eight @entity28 @entity101 @entity1 who were homozygous for the @entity28 -associated 6.6 kb allele of the ApaLI restriction fragment length polymorphism of @entity754 ('6.6. kb homozygotes') had a significantly higher body mass index [34 +/- 6.0 (SD) kg/m2] than the 18 heterozygotes (29 +/- 2.7 kg/m2) and the single subject who was homozygous for the 9.4 kb allele (29 kg/m2) (P = 0.012 by one-way analysis of variance). The body mass index of the eight @entity101 6.6 kb homozygotes was also greater than the body mass index of 29 +/- 2.4 kg/m2 observed for the eight @entity28 normotensive 6.6 kb homozygotes. In addition, the eight @entity28 @entity101 6.6 kb homozygotes had a higher plasma @entity1674 [4.2 +/- 0.77 (SEM) mmol/l] than the 18 @entity28 @entity101 heterozygotes (2.4 +/- 0.33 mmol/l; P = 0.045). Non- @entity28 @entity101 @entity1 showed no significant genotypic differences in relation to the @entity754 restriction fragment length polymorphism. 4. In the normotensive group, however, the frequency of the 6.6 kb allele of the @entity754 ApaLI restriction fragment length polymorphism in @entity28 subjects (0.54) was not significantly greater than in @entity28 subjects (0.48) [cf. the significantly (P = 0.004( different values of 0.63 and 0.39, respectively, in @entity28 and @entity28 @entity101 @entity1 .(ABSTRACT TRUNCATED AT 400 WORDS)
