@entity4101 is a novel XXXX transcriptional target and is essential for head and neck cancer cell survival.

@entity213 @entity5 @entity4101 @entity48205 @entity1366 @entity942
The chromatin-binding @entity48205 protein was recently reported to promote the growth of HPV+ and HPV- @entity213 ( @entity213 ). Relevant cellular and molecular mechanism(s) controlled by @entity48205 in @entity213 remain poorly understood. While @entity48205 is known to regulate specific transcriptional targets, global @entity48205 -dependent gene networks in @entity213 are unknown. To identify @entity48205 transcriptional signatures we performed RNA-Sequencing (RNA-Seq) in @entity213 cell lines that were either @entity942 for @entity48205 . Bioinformatic analyses and subsequent validation revealed that @entity4101 , a regulator of inflammatory signaling, and @entity4101 -dependent regulatory networks were significantly repressed upon @entity48205 knockdown in @entity213 . According to TCGA data, 14% of @entity213 specimens overexpressed @entity4101 , thus supporting possible oncogenic functions. Furthermore, genetic or pharmacologic inhibition of @entity4101 in @entity213 cell lines was sufficient to attenuate downstream signaling such as @entity1366 and to induce @entity213 cell death by apoptosis. Finally, targeting @entity48205 and @entity4101 simultaneously enhanced cell death as compared to targeting either alone. Our findings reveal that @entity4101 promotes cell survival and is an attractive therapeutic target in @entity213 cells. Thus, we propose a model wherein @entity4101 stimulates @entity5 signaling and phenotypes both independently and in conjunction with @entity48205 .
