LB01.03: INCIDENCE AND PROGNOSIS OF CANCER ASSOCIATED WITH XXXX AND COMMON ANTIHYPERTENSIVE DRUGS.

@entity1 @entity5066 @entity0 @entity5 @entity797 @entity6838 @entity7206 @entity460
OBJECTIVE: Recent observational studies have shown varied association between antihypertensive drugs and @entity6838 with either @entity5 risk or prognosis. We studied the time to incident @entity5 in two large @entity1 cohorts in relation to four antihypertensive drugs and @entity6838 . DESIGN AND METHOD: We studied a hospital admission based cohort of 525,046 @entity1 admitted at least once to the Western Infirmary and Gartnavel hospitals between 1980 and March 2013. @entity1 were classified into 6 mutually exclusive groups based on monotherapy with either ACEI/ARB( @entity5066 ), beta-blockers(BB), @entity460 antagonist(CCB), @entity7206 , @entity6838 and a control group without exposure to these drugs. All control subjects were included if they were not on the any of the above drugs and were aged 60-80 years at 1/4/2004. The inclusion criteria for the drug groups included new prescription of the drug after 1/4/2004, no previous prescription of any of the study drug, at least 90 days of prescription, discontinuation of the drug no later than 1 year before onset of @entity5 . Each of the 4 antihypertensive drug groups were mutually exclusive for any prescription for the other drugs while the @entity6838 group included all subjects exposed to @entity6838 . Age and sex adjusted time to first @entity5 diagnosis and time to death from @entity5 diagnosis were performed. RESULTS: 34,634 subjects fulfilled the inclusion criteria and of them 6,153 had a new diagnosis of @entity5 after 1/4/2004. During 8-year period follow-up 6,557 @entity1 were diagnosed with @entity5 in the hospital cohort (2,313 gastrointestinal, 2,439 lung, 464 prostate, 321 @entity0 ). The results of the multivariate adjusted @entity797 model for incident @entity5 are presented in Figure 1.(Figure is included in full-text article.) CONCLUSIONS:: Exposure to @entity6838 or beta-blocker therapy appears to be protective against incident @entity5 while CCB increased risk. Thiazides are associated with @entity5 . CCB use at diagnosis of @entity0 improved survival.
