Association of Hemodynamic Factors With XXXX Formation and Rupture: Systematic Review and Meta-analysis.

@entity1756 @entity439 @entity1642 @entity438
BACKGROUND: Recent evidence suggests a link between the magnitude and distribution of hemodynamic factors and the formation and rupture of @entity438 . However, there are many conflicting results. OBJECTIVE: To quantify the effect of hemodynamic factors on @entity439 formation and their association with @entity1756 . METHODS: We performed a systematic review and meta-analysis through October 2014. Analysis of the effects of hemodynamic factors on @entity439 formation was performed by pooling the results of studies that compared geometrical models of @entity438 " models where the @entity439 was artificially removed. Furthermore, we calculated pooled standardized mean differences between ruptured and unruptured @entity439 to quantify the association of hemodynamic factors with @entity1756 . Standard PRISMA guidelines were followed. RESULTS: The hemodynamic factors that showed high positive correlations with location of @entity439 formation were high @entity1642 ( @entity1642 ) and high gradient oscillatory number, with pooled proportions of 78.8% and 85.7%, respectively. Positive correlations were largely seen in bifurcation @entity439 , whereas negative correlations were seen in sidewall @entity439 . Mean and normalized @entity1642 were significantly lower and low shear area significantly higher in @entity1756 . CONCLUSION: Pooled analyses of computational fluid dynamics models suggest that an increase in @entity1642 and gradient oscillatory number may contribute to @entity439 formation, whereas low @entity1642 is associated with @entity1756 . The location of the @entity439 at the bifurcation or sidewall may influence the correlation of these hemodynamic factors. ABBREVIATIONS: AFI, @entity439 formation indexCFD, computational fluid dynamicsGON, gradient oscillatory numberIA, intracranial aneurysmLSA, low shear indexOSI, oscillatory shear indexSD, standard deviationSMD, standardized mean differenceSWSSG, spatial @entity1642 gradientWSS, @entity1642 .
