Idiopathic XXXX in childhood: a multicenter retrospective study.

@entity1 @entity32 @entity82 @entity1560 @entity28 @entity492 @entity490 @entity382 @entity493 @entity978 @entity99 @entity792
OBJECTIVE: To describe the clinical, laboratory, and histopathologic features of idiopathic @entity1560 in @entity1 . STUDY DESIGN: Retrospective review of all liver biopsies performed at Boston @entity1 's Hospital, Massachusetts General Hospital, and the University of Massachusetts Medical Center from 1991 to 1994. Chart review was performed when biopsies demonstrated @entity1560 . RESULTS: Eighty-two @entity1 had biopsy-proven @entity1560 . Fourteen @entity1 had @entity1560 without evidence of inherited, infectious, @entity792 . All 14 @entity1 were @entity28 , averaging 159% of ideal body weight (range, 121% to 222%). Nine @entity1 initially had transient @entity490 , two had @entity382 , and one was identified by incidental laboratory evaluation. These 12 @entity1 had biopsies because of persistent elevations of aminotransferase levels. Two other @entity1 without risk factors for @entity1560 were identified at staging laparotomy for @entity978 . The 10 @entity1 and 4 @entity1 had an average age of 13.5 years (range, 10 to 18 years). Aminotransferase elevations were modest, with @entity492 aminotransferase and @entity493 aminotransferase values averaging 77 +/- 38 IU and 129 +/- 73 IU, respectively. All had imaging studies demonstrating @entity1560 . Histologic examination of biopsy specimens revealed varying degrees of @entity1560 with @entity32 and @entity82 . CONCLUSION: Idiopathic @entity1560 occurs predominantly or exclusively in @entity28 peripubertal @entity1 . This entity represents a frequent reason for liver biopsy in this age group. The degree of @entity1560 , @entity82 , and @entity32 does not correlate with symptoms or signs, and significant @entity99 with bridging @entity82 may be present.
