Laparoscopic extended pelvic @entity1600 ( @entity1600 ) dissection as validation of the performance of XXXX positron emission tomography/computer tomography in the detection of @entity1600 metastasis in intermediate- and high-risk prostate cancer.

@entity1 @entity18808 @entity1600 @entity598
OBJECTIVES: To evaluate the accuracy of the radiopharmaceutical @entity18808 combined with positron emission tomography/computer tomography ( @entity598 -PET/CT) in @entity1600 ( @entity1600 ) staging in newly diagnosed prostate cancer cases. A second aim was to evaluate the potential discriminative properties of @entity598 -PET/CT in clinical routine. @entity1 AND METHODS: In a prospective comparative study, from July 2010 to June 2013, 53 @entity1 with newly histologically diagnosed intermediate- or high-risk prostate cancer underwent @entity598 -PET/CT investigation at one regional centre before laparoscopic extended pelvic @entity1600 dissection (ePLND) at one referral centre. The sensitivity, specificity and accuracy of @entity598 -PET/CT were calculated. Comparisons were made between true-positive and false-negative PET/CT cases to identify differences in the clinical parameters: PSA level, Gleason status, lymph metastasis burden and size, calculated risk of @entity1600 involvement, and curative treatment decisions. RESULTS: In all, 26 @entity1 had surgically/histologically confirmed @entity1600 metastasis ( @entity1600 +). @entity598 -PET/CT was true positive in 10 @entity1 , false positive in one, false negative in 16, and true negative in 26. The individual sensitivity was 38%, specificity 96%, and accuracy 68%. The @entity598 -PET/CT positive cases had significantly more involved LNs (mean 7.9 vs 2.4, P < 0.001) with larger cancer diameters (14.1 vs 4.9  mm, P = 0.001) and fewer eventually had treatment with curative intent (40% vs 94%, P <0.005), although we lack long-term outcome data. CONCLUSION: @entity598 -PET/CT has too low a sensitivity for routine @entity1600 staging but the specificity is high. The @entity598 -PET/CT positive cases have a very high burden of @entity1600 spread.
