Soluble adhesion molecules XXXX and @entity4105 in @entity625 : clinical and laboratory correlations.

@entity1 @entity66 @entity625 @entity1333 @entity146 @entity4932 @entity4105 @entity2071 @entity1851
OBJECTIVE: To determine serum and synovial fluid (SF) concentrations of soluble @entity2071 ( @entity2071 ) and @entity4105 ( @entity4105 ) in @entity1 with active @entity4932 ( @entity4932 ) and in paediatric controls and correlate them with clinical and laboratory variables. METHODS: Total of'30 @entity4932 @entity1 were evaluated: 15 with @entity66 ( @entity4932 -poly) and 15 with @entity4932 ( @entity4932 ). Paediatric age-matched control groups consisted of 11 Henoch-Sch  nlein purpura (HSP) and 10 febrile @entity1 (FC) and 28 healthy @entity1 (HC). Current medication, the erythrocyte sedimentation rate (ESR), @entity1851 (CRP) and full blood count (FBC) were recorded. Soluble @entity2071 and @entity4105 in serum and SF were measured by a sandwich ELISA kit. RESULTS: In the @entity4932 -poly group the concentration of @entity2071 was significantly higher than in healthy (p < 0.01), but notfebrile controls. Both @entity2071 and @entity4105 correlated with the active joint count (p < 0.01). In 13 @entity4932 @entity1 no correlanon was found between SF @entity2071 and @entity4105 levels and the SF leucocyte counts. No significant differences were seen in the disease control and @entity4932 groups compared to HC. A significant negative correlation with age was observed for the group as a whole ( @entity2071 : p < 0.05, @entity4105 : p < 0.01); @entity4105 correlated with the leucocyte and thrombocyte counts (p < 0.01), and both molecules with CRP (p < 0.05) and with each other (p < 0.01). CONCLUSION: A high concentration of soluble @entity2071 in @entity4932 @entity1 with @entity625 is reported here for the first time. None of the @entity1 showed signs of injection or @entity1333 , where generalised endothelial activation could be its main source. Our finding of correlations between both @entity2071 and @entity4105 levels and joint counts supports the hypothesis of their synovial origin. ICAM- I and @entity4105 could serve as a marker of @entity146 , but their predictive value needs to be further studied.
