Low-Dose (10-Gy) Total Skin Electron Beam Therapy for XXXX : An Open Clinical Study and Pooled Data Analysis.

@entity4888 @entity1 @entity137 @entity4889 @entity784 @entity272
PURPOSE: @entity784 ( @entity784 ) are dominated by @entity4888 ( @entity4888 ) and @entity4889 ( @entity4889 ), and durable disease control is a therapeutic challenge. Standard @entity272 ( @entity272 ) is an effective skin-directed therapy, but the possibility of retreatments is limited to 2 to 3 courses in a lifetime due to @entity137 . This study aimed to determine the clinical effect of low-dose @entity272 in @entity1 with @entity4888 and @entity4889 . METHODS AND MATERIALS: In an open clinical study, 21 @entity1 with @entity4888 / @entity4889 stages IB to  IV were treated with low-dose @entity272 over <2.5 weeks, receiving a total dose of 10  Gy in 10 fractions. Data from 10 of these @entity1 were published previously but were included in the current pooled data analysis. Outcome measures were response rate, duration of response, and @entity137 . RESULTS: The overall response rate was 95% with a complete cutaneous response or a very good partial response rate (<1% skin involvement with patches or plaques) documented in 57% of the @entity1 . Median duration of overall cutaneous response was 174  days (5.8  months; range: 60-675  days). @entity272 -related acute adverse events (grade 1 or 2) were observed in 60% of @entity1 . CONCLUSIONS: Low-dose (10-Gy) @entity272 offers a high overall response rate and is relatively safe. With this approach, reirradiation at times of relapse or progression is likely to be less toxic than standard dose @entity272 . It remains to be established whether adjuvant and combination treatments can prolong the beneficial effects of low-dose @entity272 .
