Life-course social position, obesity and XXXX risk in the EPIC-Spain Cohort.

@entity1 @entity6
BACKGROUND: The literature has consistently shown that extreme social-economic groups predicted @entity6 ( @entity6 ), rather than summarising the social gradient throughout all society stratification. Body mass index (BMI) was established as the principal mediator, with little support for other anthropometries. Our aim was to investigate an individual life-course social position (LiSoP) gradient and its mediators with @entity6 risk in the EPIC-Spain cohort. METHODS: 36 296 @entity1 (62% @entity1 ), mostly aged 30-65 years, and free of @entity6 at baseline (1992-1996) were followed up for a mean of 12.1 years. A combined score of paternal occupation in childhood and own adult education assessed individual life-course social risk accumulation. Hazard ratios of @entity6 were estimated using Cox regression, stratifying by centre and age, and adjusting for different explanatory models, including anthropometric indices; dietary history; smoking and physical activity lifestyles; and clinical information. RESULTS: Final models evidenced significant risks in excess of 63% for middle and 90% for lower classes of LiSoP in @entity1 ; and of 104 and 126%, respectively, in @entity1 . Concurrently, LiSoP presented significant social gradients for @entity6 risk (P < 0.01) in both sexes. Waist circumference (WC) accounted for most of the risk excess in @entity1 , and BMI and WC in @entity1 . CONCLUSIONS: LiSoP gradient was related to @entity6 risk in Spanish @entity1 and @entity1 . WC mostly explained the relationship in both genders, together with BMI in @entity1 , yet LiSoP retained an independent effect in final models.
