The urokinase receptor can be induced by XXXX through receptors of the innate immune system.

@entity19 @entity3873 @entity2069 @entity5037 @entity18870 @entity3913 @entity5751 @entity8932
Monocytic cells exposed to @entity2069 , through unknown receptors, overexpress the urokinase receptor ( @entity18870 ), a key mediator of the plasminogen activation system. We show that combined blockade of @entity5751 and @entity8932 causes a significant inhibition of @entity2069 -induced @entity18870 in Mono Mac 6 (MM6) cells. Other pattern recognition receptors tested (CD11b/CD18, the @entity3913 receptor, and the @entity5037 receptor) did not have demonstrated roles in @entity2069 -mediated @entity18870 induction. We dissected the result for @entity5751 andTLR2 by investigating the singular contributions of each. Independent functional blockade of @entity5751 or @entity8932 failed to inhibit @entity2069 -mediated @entity18870 induction. @entity3873 differentiation of MM6 cells increased @entity5751 expression 12-fold but did not augment @entity2069 -mediated @entity18870 expression. Peritoneal exudate macrophages (PEM) from @entity5751 - or @entity8932 -deficient @entity19 were not defective in @entity2069 -mediated synthesis of @entity18870 mRNA and protein. Increased @entity18870 mRNA or protein or both were apparent in PEM from transgenic and control @entity19 , even at a ratio of one Borrelia spirochete per cell. We conclude that signaling for the @entity18870 response, as mediated by @entity2069 , proceeds with @entity5751 and @entity8932 as partial contributors. That part under control of @entity5751 and @entity8932 represents a new link between the host plasminogen activation and innate immunity systems.
