XXXX ( @entity1476 ) gene polymorphism and cardiovascular comorbidity in type 2 @entity6 @entity1 .

@entity1 @entity455 @entity64 @entity6 @entity1476 @entity731 @entity393 @entity65
OBJECTIVE: Matrix metalloproteinases (MMPs) play an important role in pathogenesis of @entity731 and @entity455 . We hypothesized that @entity1476 might be a susceptibility gene for @entity65 ( @entity65 ) in @entity6 . The aim of this study was to evaluate the association between C(-1306)T functional polymorphism in the @entity1476 gene and risk of @entity65 in type 2 @entity6 @entity1 . METHODS: We examined 1090 @entity1 with T2DM and 612 controls. All subjects were genotyped for the C(-1306)T polymorphism by polymerase chain reaction (PCR) and restriction analysis. RESULTS: A significant @entity393 allele frequency was observed in @entity1 with @entity65 versus those with no @entity65 (OR 0.44, 95% CI 0.36-0.52, p<0.0001). In contrast, OR for CC genotype was 2.19 (1.79-2.68, p<0.0001), conferring 2-fold greater odds for @entity65 . When the distribution of C(-1306)T was compared in subgroups with different clinical phenotypes of @entity65 , @entity1 with @entity64 had the lowest frequency of T allele (6% vs. 11%), compared to entire @entity65 + group (p<0.05). CONCLUSIONS: T2DM @entity1 carrying the T allele of @entity1476 C(-1306)T polymorphism have a significantly reduced risk of @entity65 . The C(-1306)T polymorphism is associated with susceptibility to @entity64 in T2DM @entity1 .
