Idiotype-specific T cells in XXXX stage I: an evaluation by four different functional tests.

@entity1 @entity665 @entity1582 @entity379 @entity56 @entity1199 @entity405
Idiotype-specific T cells were characterized in @entity1 with @entity1582 stage I by analysing idiotype-induced DNA synthesis ( @entity665 incorporation), @entity1199 and @entity379 production at the single cell level (ELISPOT) (in vitro tests) and @entity56 ( @entity56 ) skin reaction (in vivo test). In seven out of eight @entity1 at least one of the four tests was positive. In five @entity1 three or more tests were positive. One @entity1 was negative in all four tests. Six @entity1 had both @entity1199 and @entity379 -secreting cells and three of them also a @entity56 response. Furthermore, those three @entity1 with a proliferative response also had @entity1199 and @entity379 -secreting cells induced by the idiotype. The data indicate that part of the idiotype-specific T cell fraction belongs to the CD4 Th1 cell population. Whether @entity405 -specific T cells also were present could not be ruled out. The present study provides further support for the existence of idiotype-specific T cells in @entity1582 . Such cells might be an important target for an immune-mediated therapeutic approach.
