High-Grade Cervical Dysplasia following Radiation Therapy for Invasive XXXX : A Report of Four Cases.

@entity5 @entity1 @entity1141
INTRODUCTION: The standard treatment for locally advanced cervical @entity5 is chemoradiation, with the majority of @entity1 having a complete response to the therapy. The current surveillance recommendations from the Society of Gynecologic Oncology include annual cytology, with a small proportion of @entity1 subsequently diagnosed with high-grade cervical @entity1141 (CIN 2/3). To date, there is limited information regarding the optimal treatment and outcome for @entity1 diagnosed with CIN 2/3. The current report describes the diagnosis, management and outcome of 4 @entity1 diagnosed with CIN 2/3 following chemoradiation. CASE DESCRIPTION: We describe 4 @entity1 who developed CIN 2/3 seven months to 8 years following radiation therapy for locally advanced cervical @entity5 . All 4 @entity1 were asymptomatic and the abnormalities were first detected by a Pap test. Three of the @entity1 were managed conservatively with observation, and the CIN 2/3 resolved without intervention. One @entity1 underwent 2 cervical conizations followed by a hysterectomy with no residual @entity1141 noted on the hysterectomy specimen. CONCLUSION: The majority of @entity1 with recurrent cervical @entity5 after chemoradiation are symptomatic, and most cases are detected by a physical examination. The role of cytology, colposcopy and biopsies may be of limited value. Furthermore, the significance of the diagnosis of CIN 2/3 in @entity1 previously treated with radiation therapy was not associated with recurrent disease in the 4 @entity1 described. Our results suggest that cytology may be of limited value in detecting recurrence in @entity1 following radiation therapy, even when CIN 2/3 is detected.
