Increase of a urokinase receptor-related low-molecular-weight molecule in XXXX .

@entity1 @entity1472 @entity5 @entity14 @entity3 @entity2290
Proteolytic activity is important for @entity5 growth and @entity3 . Plasminogen and @entity2290 ( @entity2290 ) constitute one of the most extensively studied proteolytic systems believed to participate in these processes. @entity2290 cleaves plasminogen to plasmin, which in turn degrades surrounding extracellular matrix and allows @entity5 cells to migrate to other areas. The specific receptor for @entity2290 ( @entity2290 ) has also been implicated as an essential modulator in this pathway. Eleven paired samples of @entity14 and normal mucosal tissues from the same @entity1 were removed at surgery. The tissues were homogenized and the supernatants assayed for @entity2290 immunoreactivity, @entity2290 antigen concentration, @entity2290 binding activity and @entity2290 activity. Immunoblot analysis showed that a major @entity2290 species of approximately 55 kDa was present in all tissues. In addition, a protein band of approximately 41 kDa, which crossreacted with anti- @entity2290 antibodies, was also found in the @entity5 . This protein band was either absent, or present in relatively small amounts in the normal colorectal tissues. Cross-linking experiments showed that the approximately 55 kDa band only, and not the approximately 41 kDa band, was able to bind either single chain @entity2290 (scu-PA) or the @entity1472 terminal fragment of urokinase (ATF). The @entity5 samples also exhibited highly elevated @entity2290 activity and @entity2290 antigen relative to the corresponding normal tissues. Elevated @entity2290 activity appeared to correlate with elevated @entity2290 antigen in @entity14 , but not in the normal tissues. These increases were also associated with increase of the @entity2290 -related, low-molecular-weight protein in the @entity5 samples. The measurement of @entity2290 and the @entity2290 -related protein, in addition to @entity2290 activity, could have diagnostic or prognostic value in this type of @entity5 .
