Intensity modulated radiotherapy with simultaneous integrated boost vs. conventional radiotherapy with sequential boost for XXXX - A preliminary result.

@entity1 @entity137 @entity0 @entity5 @entity1909 @entity6937
PURPOSE: This study was aimed to assess the acute dermatological adverse effect from two distinct RT techniques for @entity0 @entity1 . We compared intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and conventional radiotherapy followed by sequential boost (CRT-SB). METHODS: The study population was composed of 126 consecutive @entity0 @entity1 treated with breast conserving surgery. Sixty-six @entity1 received IMRT-SIB to 2 dose levels simultaneously. They received 50.4  Gy at 1.8  Gy per fraction to the whole breast and 60.2  Gy at 2.15  Gy per fraction to the @entity5 bed by integral boost. Sixty @entity1 in the CRT-SB group received 50  Gy in 25 fractions to the whole breast followed by a boost irradiation to @entity5 bed in 5-7 fractions to a total dose of 60-64  Gy. Acute @entity137 were documented in agreement with the Common Terminology Criteria for Adverse Events version 3 (CTCAE v.3.0). RESULTS: Ninety-eight @entity1 had grade 1 radiation @entity1909 while 14 @entity1 had grade 2. Among those with grade 2, there were 3 @entity1 in IMRT-SIB group (4.5%) while 11 in CRT-SB group (18.3%). (P  =  0.048) There was no @entity1 with higher than grade 2 @entity137 . Three year local control was 99.2%, 3-year disease free survival was 97.5% and 3-year overall survival was 99.2%. CONCLUSIONS: A significant reduction in the severity of @entity6937 from IMRT-SIB comparing with CRT-SB is demonstrated.
