Ovarian function following marrow transplantation for XXXX or @entity1778 .

@entity1 @entity49844 @entity2150 @entity786 @entity1778 @entity348 @entity2670
One hundred eighty-seven @entity1 between 13 and 49 years of age had ovarian function evaluated from 1 to 15 years (median, 4) after marrow transplant for @entity2150 or @entity1778 . Among 43 @entity1 transplanted for @entity2150 following 200 mg/kg @entity786 ( @entity49844 ), all 27 less than 26 years of age, but only five of 16 greater than 26 years of age recovered normal ovarian function. Nine of the 43 have had 12 pregnancies, resulting in eight live births, and two elective and two spontaneous abortions. All eight @entity1 are normal. Nine of 144 @entity1 transplanted for @entity1778 following 120 mg/kg @entity49844 and 9.20 to 15.75 Gy @entity348 ( @entity348 ) recovered ovarian function. Two of these nine have had three pregnancies, resulting in two spontaneous and one elective abortion. The probability of having @entity2670 was 0.35 by 7 years for @entity1 receiving @entity49844 alone and was 1.00 at 1 year for @entity1 receiving @entity49844 plus @entity348 (P less than .0001). By 7 years after transplant the probabilities of having normal ovarian function were 0.92 after @entity49844 alone and 0.24 after @entity49844 plus @entity348 (P less than .0001). Multivariate analysis showed that @entity348 was the only factor significantly influencing @entity2670 and that both @entity348 and greater @entity1 age at transplant were significantly associated with a decreased probability of recovering normal ovarian function. These data demonstrate that after high-dose @entity49844 , recovery of ovarian function occurs in younger @entity1 and in a minority of older @entity1 , but after @entity49844 and @entity348 , recovery occurs in only a few younger @entity1 and none of the older @entity1 .
