The effect of chronic XXXX on left ventricular size, function, and interventricular septal motion.

@entity1 @entity101 @entity120 @entity519 @entity453
The effect of right ventricular pressure overload secondary to chronic @entity120 on left ventricular size and function and on interventricular septal motion was studied in 13 @entity1 in whom @entity453 , @entity101 , and @entity519 were excluded. Regional and global left ventricular function were assessed by computer-assisted analysis of two-dimensional directed M-mode echocardiograms obtained within 24 hours of a hemodynamic study. Septal position and motion were further analyzed by delineating seven points along the right and left sides of the septum during a single cardiac cycle. All echocardiographic data were compared to those of 10 normal subjects. Mean values for right ventricular systolic, mean pulmonary artery and pulmonary capillary wedge pressures were: 71 +/- 26 mm Hg, 46 +/- 16 mm Hg, and 7 +/- 1 mm Hg, respectively. Septal motion was interpreted from the M-mode echocardiograms as normal in seven @entity1 (group I) and abnormal in the remaining six @entity1 (group II). The only hemodynamic parameter which distinguished these two patterns was delta P, the transseptal systolic pressure gradient across the interventricular septum, which was significantly different (p less than 0.02) in group I (delta P = 65 +/- 16 mm Hg) from that of group II (delta P = 21 +/- 24 mm Hg). As a result of abnormal septal position, the septal-free wall dimensions of the left ventricle were reduced, but there was no evidence of depressed left ventricular performance in these @entity1 . We conclude that resting left ventricular function is well preserved in @entity1 with @entity120 , despite significant alterations in septal position and left ventricular size.(ABSTRACT TRUNCATED AT 250 WORDS)
