Liver lesions found at colectomy in XXXX : correlation between histological findings and biochemical parameters.

@entity1 @entity1560 @entity31 @entity991 @entity99
AIMS: To classify lesions discovered at colectomy in @entity1 with @entity31 ; to assess the importance of histological findings by correlating them with biochemical parameters. METHODS: Liver tissue specimens taken at colectomy from 59 @entity1 with chronic @entity31 were studied using light microscopy. The findings were compared with results of biochemical liver function tests. RESULTS: Abnormal laboratory findings were found in 12 @entity1 with liver histology consistent with @entity991 . Non-specific reactive @entity99 was observed in six @entity1 , eight had @entity1560 , and three minor non-specific parenchymal changes. Twenty nine @entity1 had normal liver histology. The highest cholestatic serum enzyme activities were seen in two @entity1 with @entity991 . Cholangiography in these @entity1 also revealed changes in the extrahepatic bile ducts. However, identical histological changes were also present in @entity1 with only slightly abnormal or even normal liver enzyme activities. CONCLUSION: Biochemical tests of liver function do not reliably indicate the extent or severity of bile duct damage in @entity31 , the assessment of which requires liver biopsy.
