Two Phenotypes of Traditional Serrated XXXX Nationwide Survey in Iceland.

@entity1 @entity1127 @entity10319 @entity189 @entity652 @entity1141 @entity2513
Iceland has a total population of 300,000 inhabitants. All @entity1 consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all @entity1127 were endoscopically removed. Out of the total 3,037 @entity2513 ( @entity2513 ), 308 (10.2%) were @entity652 ( @entity652 ). @entity652 were divided according the predominant histological phenotype (>50%) into those with ectopic crypt formations (ECF), and those with unlocked serrations (US). ECF- @entity10319 accounted for 5.9% (178/3037) and US- @entity10319 for 4.3% (130/3037). The majority of @entity1 with ECF- @entity10319 and US- @entity10319 were >= 60 years of age (74.1% and 76.2%, respectively). Notwithstanding, when @entity1 having advanced @entity652 (with high-grade @entity1141 , with or without @entity189 ) were listed by age, those with ECF- @entity10319 were significantly younger than those with US- @entity10319 (p<0.05). ECF- @entity10319 were more frequently left-sided (71.8%), whereas US- @entity10319 were more frequently right-sided (60.0%). @entity189 evolved more frequently in ECF- @entity10319 (7.8%) and in US- @entity10319 (7.7%) than in tubular @entity652 and in villous/tubulovillous adenonas (0.1% and 4.4%, respectively). Comparative studies indicated that the incidence rates/year of ECF- @entity10319 and US- @entity10319 were significantly higher in Iceland than in Sweden or in Italy (p<0.05). Genetic and putative epigenetic (environmental) factor(s) might account for the high incidence rate/year of ECF- @entity10319 and US- @entity10319 in this country.
