A mechanism-based pharmacological evaluation of efficacy of Flacourtia indica in management of @entity2299 and oxidative stress in hyperlipidemic XXXX .

@entity407 @entity69840 @entity137 @entity2299 @entity19 @entity4212 @entity1674 @entity33534 @entity35 @entity922 @entity16287 @entity12218 @entity165
BACKGROUND: Flacourtia indica (Burm. f.) Merr. is a medicinal plant indigenous to India and is broadly used worldwide for the treatment of a variety of health ailments. The present study was experimented on hyperlipidemic Charles Foster @entity35 with the aim to explore the possible mechanism responsible for the antidyslipidemic activity of the hydromethanolic extract from @entity69840 leaves (FIL). METHODS: @entity407 was induced by a single intraperitoneal dose of @entity12218 in Charles Foster @entity35 . The plasma lipid levels were estimated in control and treated groups. The antioxidant potential of @entity69840 was assessed in both enzymatic and non-enzymatic systems. An acute @entity137 study of high-performance liquid chromatography (HPLC)-fingerprinted extract was carried out in Swiss albino @entity19 . RESULTS: The @entity69840 extract at a dose of 150 mg/kg significantly lowers the plasma level of total @entity165 (17%), @entity1674 (13%), and phospholipids (16%) by increasing post-heparin lipolytic activity (19%) and lecithin- @entity165 -acyltransferase activity (20%) in @entity33534 -induced hyperlipidemic @entity35 . In addition, the @entity69840 extract showed significant in vitro antioxidant and anti-adipogenic activity. HPLC analysis indicates the presence of @entity16287 and @entity4212 in the extract, and the extract was found to be non-toxic up to a dose of 2000 mg/kg body weight in the @entity137 study. CONCLUSIONS: These finding suggest that @entity69840 holds significant potential in preventing @entity922 induced by @entity2299 along with oxidative stress.
