Intra- and postoperative low-dose @entity3652 for adolescent XXXX surgery: a randomized controlled trial.

@entity1 @entity13295 @entity1937 @entity1635 @entity3652 @entity2112 @entity1875 @entity1286 @entity158 @entity1209
BACKGROUND: In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose @entity3652 decreased postoperative @entity1286 requirement and @entity1286 -related adverse effects as @entity1209 after @entity1635 surgery. METHODS: After IRB approval and informed consent, 36 @entity1 , aged 10-19  years, undergoing posterior correction surgery for adolescent @entity2112 , were randomly allocated into two groups: intra- and postoperative @entity3652 infusion at a rate of 2   g/kg/min until 48  h after surgery ( @entity3652 group, n  =  17) or infusion of an equal volume of saline (placebo group, n  =  19). All @entity1 were administered total intravenous anesthesia with @entity1875 and @entity1937 during surgery and intravenous @entity1286 using a @entity1 -controlled analgesia device after surgery. The primary outcome was cumulative @entity1286 consumption in the initial 48  h after surgery. @entity158 scores (Numerical Rating Scale, @entity13295 , 0-10), sedation scales, incidence of @entity1209 ( @entity1209 ), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48  h after surgery. RESULTS: @entity1 characteristics did not differ between the two groups. Cumulative @entity1286 consumption for 48  h after surgery was significantly lower in the @entity3652 group compared to the placebo group (0.89      0.08  mg/kg vs. 1.16      0.07  mg/kg, 95% confidence interval for difference between the means, 0.03-0.48  mg/kg, P  =  0.019). @entity13295 @entity158 , sedation scales, and incidence of @entity1209 did not differ between the two groups. Antiemetic consumption was significantly smaller in @entity3652 group. CONCLUSIONS: Intra- and postoperative infusion of low-dose @entity3652 reduced cumulative @entity1286 consumption and antiemetic requirement for 48  h after surgery.
