Effects of acute, subacute, and chronic @entity6 on carbohydrate and energy metabolism in XXXX sciatic nerve. Relation to mechanisms of peripheral neuropathy.

@entity1734 @entity8371 @entity8580 @entity6 @entity10835 @entity63 @entity5121 @entity948 @entity19721 @entity3949 @entity413 @entity4567 @entity519 @entity880 @entity6178 @entity35 @entity2388 @entity3363 @entity855 @entity3776
To address the problem of the pathogenesis of @entity3949 , @entity35 were made @entity6 by @entity10835 administration, and sciatic nerves were sampled for electrolyte and water content and levels of selected @entity3363 and intermediates in energy metabolism at 3, 6, and 26 weeks. Significant increases were seen in the nerve content of @entity413 , @entity5121 , and @entity948 . Decreases of @entity8580 were not statistically significant. @entity3776 was increased at all times; @entity4567 was elevated at 6 and 26 weeks. Nerve @entity855 and @entity1734 levels were both increased concomitantly, as was the energy charge. Nerve @entity880 levels increased only at 26 weeks when plasma @entity880 levels were also high. Plasma @entity6178 bodies were elevated throughout the 26-week experimental interval. It is postulated that @entity6178 bodies were being used as alternative metabolic fuels in @entity6 , thereby causing inhibition of @entity2388 oxidation and increased aerobic production of @entity880 . Increased plasma @entity6178 body levels could also inhibit hepatic @entity880 uptake. There was no other evidence for @entity519 / @entity63 . @entity880 : @entity2388 ratios did not differ from control values at any time in these @entity19721 animals. Five major hypotheses have been proposed to explain the pathogenesis of @entity3949 : 1) @entity519 / @entity63 , 2) hyperglycemic pseudohypoxia, 3) @entity8580 deficiency, 4) @entity948 and @entity8371 accumulation and osmotic disequilibrium, and 5) nonenzymatic glycation of macromolecules by @entity948 and @entity413 . The data obtained in this study seem to fit best with hypotheses 4 and perhaps 5.
