The prognostic value of standardized reference values for speckle-tracking global longitudinal strain in XXXX .

@entity1 @entity712 @entity943 @entity67 @entity1121 @entity204
UNASSIGNED: Speckle-tracking left @entity67 (GLS) assessment may provide substantial prognostic information for @entity1121 ( @entity1121 ) @entity1 . Reference values for GLS have been recently published. We aimed to evaluate the prognostic value of standardized reference values for GLS in @entity1121 @entity1 . An analysis of @entity1121 clinic @entity1 who underwent GLS was performed. GLS was defined as normal (more negative or equal to -16  %) and abnormal (less negative than -16  %) based on recently published reference values. @entity1 were followed for a composite of events including @entity712 hospitalization, sustained @entity943 , and all-cause @entity204 . The power of GLS to predict outcomes was assessed relative to traditional clinical and echocardiographic variables present in @entity1121 . 79 @entity1121 @entity1 were followed for a median of 22  months (interquartile range 9-30  months) after imaging. During follow-up, 15 @entity1 (19  %) met the primary outcome. Abnormal GLS was the only echocardiographic variable independently predictive of the primary outcome [multivariate Hazard ratio 5.05 (95  % confidence interval 1.09-23.4, p = 0.038)]. When combined with traditional clinical variables, abnormal GLS remained independently predictive of the primary outcome [multivariate Hazard ratio 5.31 (95  % confidence interval 1.18-24, p = 0.030)]. In a model including the strongest clinical and echocardiographic predictors of the primary outcome, abnormal GLS demonstrated significant incremental benefit for risk stratification [net reclassification improvement 0.75 (95  % confidence interval 0.21-1.23, p < 0.0001)]. Abnormal GLS is an independent predictor of adverse outcomes in @entity1121 @entity1 . Standardized use of GLS may provide significant incremental value over traditional variables for risk stratification.
