@entity1 XXXX : a distinct pathological entity resulting from impaired fluid handling.

@entity1 @entity39 @entity4 @entity5719 @entity45 @entity62 @entity130
BACKGROUND: In the first months of life the subcortical @entity62 appears prone to fluid accumulation and cystic change. This condition has generally been considered to be due to @entity130 ( @entity130 ) and is grouped with other forms of @entity62 including @entity5719 ( @entity5719 ). AIMS: Our aim was to describe the sequential tissue changes in the formation of @entity5719 in the @entity1 brain and to delineate this from other forms of @entity62 in order to better understand its pathogenesis and aetiology. STUDY DESIGN: Standard samples of the frontal lobe, including subcortical @entity62 , were stained to demonstrate the cellular processes responsible for subcortical cyst formation in @entity1 who had died from @entity130 ( @entity130 ) and @entity4 . Cases were of @entity1 who had survived for known periods after collapse in order to determine the time course of the pathological changes. SUBJECTS: 20 @entity1 under 5 months of age with global @entity130 and no other primary brain pathology, and who had survived for between 2h and 13 days after collapse. OUTCOME MEASURES: The description of the sequential changes leading to subcortical cyst formation in @entity1 after severe global @entity130 . RESULTS: With increasing time of survival after global @entity130 the subcortical @entity62 became more oedematous. @entity45 were seen after one day but were most common in @entity1 surviving more than 5 days. Cysts were not associated with cellular responses and seemed to be the result of fluid accumulation. The pathology was quite distinct from @entity5719 which is due to tissue @entity39 . CONCLUSIONS: @entity5719 results from fluid accumulation and not @entity39 . Predisposition to fluid accumulation may be age-related and due to impairment of fluid handling pathways which remain immature in this age group. Potential mechanisms are discussed.
