Ternary systems of @entity1623 with @entity26239 and XXXX .

@entity1522 @entity535 @entity6779 @entity26239 @entity534 @entity9108 @entity1623 @entity376 @entity2596 @entity369
The purpose of the present study was to investigate the combined effect of @entity26239 and different @entity1522 ( @entity9108 , LYS; @entity2596 , @entity2596 ; @entity6779 , LEU; and @entity534 , @entity534 ) on the solubility of @entity1623 , a poorly water-soluble anti-inflammatory drug. Aqueous solubilities of @entity1623 in binary and ternary systems with @entity26239 and each @entity535 were determined. The pH was measured in all solubility studies and its role on drug solubility variation was evaluated. @entity369 was the most effective @entity535 in improving drug solubility and the only one which showed a synergistic effect when used in combination with @entity26239 . In contrast, some reduction with respect to the theoretical drug solubility (i.e. the sum of the solubilities in the presence of cyclodextrin and @entity535 separately) was observed in ternary combinations with the other @entity1522 . This occurred also in the case of @entity376 , despite the higher solubility of its ternary system in comparison with the binary cyclodextrin complex at pH 7. Phase-solubility experiments showed that the ternary system with @entity369 (pH approximately 7) exhibited a stability constant 3.6 times higher and was about 5.5 times more effective in improving drug solubility than the binary complex in buffered (pH approximately 7) aqueous solutions. These results demonstrated that the high increase in the drug solubility shown by ternary systems with @entity369 was not simply due to a favorable pH change but to multicomponent complex formation. Solid products of @entity1623 with @entity26239 , and/or @entity369 , prepared by different methods, were characterized by Differential Scanning Calorimetry (DSC), Hot Stage Microscopy (HSM) and Scanning Electron Microscopy (SEM).
