Prognostic evaluation of @entity2440 , @entity4729 , XXXX , @entity1364 , Ki67 and @entity5962 expression in @entity356 .

@entity1 @entity1364 @entity4729 @entity2440 @entity3012 @entity5962 @entity4731 @entity3 @entity356
The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .
