@entity479 treatment in the prevention of XXXX episodes in @entity3458 .

@entity1 @entity251 @entity1087 @entity1420 @entity19 @entity3458 @entity158 @entity2827 @entity479
16 male and 28 female @entity1 experiencing moderately severe @entity158 during episodes of @entity3458 at least once in 3 months with little or no fever or exacerbations of @entity1087 were selected for a cross-over trial of low doses of steriods against saline solution. The @entity1 each completed 4-6 months of treatment. All @entity1 were on regular folates and had high or normal serum-iron values. Weights ranged from 24-134 pounds and ages from 2-35 years. Male @entity1 were randomly assigned to either @entity251 in oil (10 mg in 1 ml) or physiological @entity2827 solution (1 ml). Females were randomly assigned to @entity1420 in oil (10 mg in 1 ml) or physiological saline solution. A score was computed each month reflecting the severity, duration, and frequency of episodes of @entity158 . About 80% of the individuals on steriods had good responses and about the same proportion of the @entity2827 group had very poor responses. 22 of the original 31 @entity1 stopped taking saline injections after the 1 @entity19 weeks. The packed-cell volumes in the @entity479 group rose during the period of @entity479 injections, while there was no appreciable change in the @entity2827 group. There were no sex differences in the pattern of response and no deleterious side effects were noted.
