Histopathology of cortex and white matter in pediatric XXXX : comparison with those of partial @entity410 .

@entity1 @entity854 @entity410 @entity302
@entity302 in older @entity1 have increasingly been recognized as a distinct @entity410 type and subset of these @entity1 are considered for surgical resection. This study compares histopathology and magnetic resonance imaging (MRI), especially focusing the difference between the cortical grey matter and the subcortical white matter to understand the extensive @entity302 in @entity1 with @entity302 . We examined 22 @entity1 consisting of 11 @entity1 with @entity302 and 11 with partial @entity410 . Scalp video electroencephalography (EEG) showed interictal generalized @entity302 (9 @entity1 with @entity302 vs. 1 with partial @entity410 ) and ictal generalized @entity302 (10 vs. 3). We found @entity854 in a single lobe (6 vs. 7) and multiple lobes (2 vs. 1). Surgical resections were performed across multiple lobes (9 vs. 2), comparing within a single lobe (2 vs. 9), (p<0.001). Histopathology showed abnormal cortical organizations as FCD (2 vs. 5) and microdysgenesis (4 vs. 4), normal (4 vs. 1). Two @entity1 with @entity302 showed hyaline proteoplasmic astrocytopathy. There were heterotopic neurons (10 vs. 10), cluster of oligodendroglia (8 vs. 7), balloon cells (2 vs. 5) and blurred myelination (1 vs. 4), in the white matter. @entity410 -free outcomes were seen in seven @entity1 with @entity302 (64%) and four with partial @entity410 (36%). The multilobar epileptogenic zones existed in @entity1 with @entity302 , compared with the focal epileptogenic zone in @entity1 with partial @entity410 . There was no difference of MRI and histopathology findings in cortex and subcortical white matter between two groups.
