Prevention of lipopolysaccharide-induced intussusception in @entity19 by the @entity10178 inhibitor XXXX .

@entity2491 @entity13586 @entity10178 @entity19 @entity3473 @entity637
@entity3473 ( @entity3473 ), an invagination of a portion of the intestine into itself, has recently attracted considerable interest after the withdrawal of a rotavirus vaccine because of reports on increased risk of @entity3473 shortly after vaccination. The present study was designed to shed further light on the mechanism of @entity3473 formation and its prevention. @entity3473 was induced in adult @entity19 by intraperitoneal injection of lipopolysaccharide (LPS; 8 mg/kg) from @entity2491 . The presence of @entity3473 was confirmed at laparotomy. The serum levels @entity637 were measured with ELISA. Six hours after LPS injection, 14.5% of the animals demonstrated @entity3473 . A total of 65 animals received @entity13586 (20 mg/kg), a selective @entity10178 inhibitor, 15-30 min before intraperitoneal injection of LPS, and only two (3%) in this group demonstrated @entity3473 6 h later (P < 0.05 vs. control). We confirmed the well-known increase in serum @entity637 levels in response to LPS; however, this increase was not blocked by @entity13586 pretreatment. Notably, there was no correlation between the serum @entity637 levels and the development of @entity3473 . The results show that the occurrence of @entity3473 can be significantly decreased by pretreatment with a selective @entity10178 inhibitor.
