Effects of alpha 1-acid glycoprotein in different rodent models of XXXX .

@entity1 @entity64 @entity548 @entity19 @entity1457 @entity35 @entity298 @entity130
It was the aim of the present study to investigate the effects of the acute phase protein alpha 1-acid glycoprotein in different models of @entity1457 . The @entity1 plasma preparation used was without effect on mortality in lipopolysaccharide-injected @entity19 when administered in two different doses (1 or 0.33 g/kg i.v.) and according to different treatment schedules. The same preparation significantly increased survival rate (48 h) in @entity35 with @entity298 . This effect was seen when alpha 1-acid glycoprotein (200 mg/kg i.v.) was given 15 min prior to and 24 h after cecal puncture. All other dose regimes tested were without significant effect on survival rate. A @entity548 / @entity1457 model (including a defined @entity130 ) in @entity35 resuscitated with 200 mg/kg alpha 1-acid glycoprotein resulted in significantly higher values of mean arterial blood pressure, cardiac output and @entity64 volume when compared to corresponding values obtained after resuscitation with Ringer's solution or 200 mg/kg albumin i.v. (free of alpha 1-acid glycoprotein; placebo formulation). Taking all other possible mechanisms of alpha 1-acid glycoprotein into consideration, the partially protective effects of the preparation are explained by enhancing the capillary barrier function and thereby maintaining perfusion of vital organs.
