@entity419 PET-CT as a supplement to CT/MRI for detection of nodal @entity3 in hypopharyngeal SCC with XXXX .

@entity1 @entity135 @entity419 @entity5 @entity957 @entity3
OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity419 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity3 in @entity1 with @entity957 (SCC) with @entity135 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity1 with @entity135 (36 @entity1 and 3 @entity1 ; average age 65.4 years) underwent @entity5 resection and neck dissection as primary treatment. All @entity1 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity1 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity1 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity3 in @entity1 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.
