Effect of the angiotensin II receptor blocker XXXX on fibrinolysis in @entity1 with mild @entity101 .

@entity1 @entity2289 @entity101 @entity1564 @entity209 @entity22666 @entity3479
AIM: Impaired fibrinolysis is frequently observed in @entity1 with the @entity209 . Aim of the study was to examine the short-term effect of angiotensin II receptor blockade on the fibrinolytic system. METHODS: Seventy-four @entity1 with mild @entity101 were randomly assigned to a 7-day treatment period with either 16 mg @entity22666 or placebo. Several variables of the fibrinolytic system such as @entity2289 ( @entity2289 ) antigen and activity, @entity3479 ) antigen and activity as well as circulating @entity3479 / @entity2289 complexes were determined. RESULTS: At baseline, the body mass index but not blood pressure was positively associated with @entity2289 antigen (r=0.314, p<0.01) and @entity2289 activity (r=0.425, p<0.01) but negatively with @entity3479 activity (r=-0.187, p < 0.05). A 7-day treatment with 16 mg @entity22666 resulted in a significant greater reduction of diastolic blood pressure (-10.3 +/- 10.8 mmHg vs.-5.8 +/- 8.5 mmHg, p=0.03). However, there was no significant effect of @entity1564 on all parameters of the fibrinolytic system under investigation, i.e. circulating @entity2289 antigen, @entity2289 activity, @entity3479 antigen, @entity3479 activity and @entity3479 / @entity2289 complexes. Furthermore, @entity1564 did not affect the characteristic circadian pattern of the variables of the fibrinolytic system. CONCLUSION: We conclude that short-term blockade of the angiotensin II receptor subtype 1 with @entity1564 does not have an impact on fibrinolysis in @entity1 with mild @entity101 .
