A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism @entity64795 in @entity6800 and XXXX .

@entity73167 @entity6800 @entity69307 @entity1 @entity4557 @entity0 @entity5 @entity41643 @entity281 @entity11709 @entity64795 @entity1722
BACKGROUND: Toll-like receptors (TLRs) regulate the balance between the innate and adaptive immune responses. Missense single nucleotide polymorphisms (SNPs) in TLRs might be functional and thus influence the risks of @entity281 and @entity5 development. Here, we investigated the association of two missense SNPs, @entity64795 ( @entity73167 ) in the @entity6800 gene and @entity41643 ( @entity69307 ) in the @entity11709 gene, with @entity4557 ( @entity4557 ) in a cohort of prospectively observed @entity0 @entity1 . METHODS: In this prospective observational study, @entity64795 in @entity6800 and @entity41643 in @entity11709 were genotyped in 715 @entity1 with primary @entity0 in a Chinese population. RESULTS: Univariate analysis revealed that the @entity1 with the AA genotype of @entity64795 had a shorter @entity4557 compared with those carrying the G allele in the recessive model (P<0.01), but this finding was not observed with the dominant model (P = 0.31). The results remained significant after adjusting for the clinical parameters in the recessive model (HR = 3.53, 95% confidence interval [CI]: 1.98-6.31, P<0.01). Further survival analysis indicated that this SNP was significant in the luminal-B, @entity0 ( @entity0 ), and @entity1 @entity1722 -positive (HER2+) @entity1 using the recessive model but that it was not significant in the luminal-A @entity1 . The SNP @entity41643 showed a non-significant tendency toward an increased @entity4557 rate in the @entity1 with the TT genotype. CONCLUSION: Our results suggest that the SNP @entity64795 in @entity6800 may influence @entity1 outcome. Further studies with larger sample sizes should be conducted to validate our findings.
