The treatment of penile @entity2735 ( XXXX ) within a UK supra-regional network.

@entity5 @entity1 @entity1487 @entity2735
OBJECTIVES: To review outcomes of the treatment of @entity2735 ( @entity2735 ) of the penis at a large supra-regional @entity5 network, where centralisation has permitted greater experience with treatment outcomes, and suggest treatment strategies. @entity1 AND METHODS: The network @entity5 database, which details presentation, treatment and complications was analysed from 2003 to 2010, identifying @entity1 with @entity2735 , with a minimum follow-up of 2 years, looking at treatments administered and outcomes. RESULTS: In all, 57 @entity1 with mean (range) age of 61 (34-91) years were identified. In all, 18 were treated by circumcision only, 20 by circumcision and local excision (LE) and 19 by circumcision and 5-flurouracil ( @entity1487 ). The mean (range) follow-up was 3.5 (2-8) years. Of those treated by circumcision none subsequently developed @entity2735 on the glans. For those who underwent circumcision + LE, five of 20 (25%) developed recurrence requiring further treatment. Of those treated by circumcision + @entity1487 , 14/19 (73.7%) completely responded. Of the five incomplete responders, two had focal invasive @entity5 at repeat biopsy. One incomplete responder underwent glansectomy and four grafting. No complete responders relapsed. Complications of @entity1487 included significant inflammatory response in seven (36.8%), with two requiring hospital admission and one neo-phimosis (5.3%). CONCLUSION: This study suggests that @entity1 undergoing circumcision for isolated @entity2735 and complete responders to @entity1487 may require only short-term follow-up, as recurrence is unlikely, whereas longer follow up is required for all other @entity1 . However, numbers in this study are small and larger studies are needed to support this. An incomplete response to @entity1487 dictates immediate re-biopsy, as it carries a significant chance of previously undetected invasive disease.
