[Results of whole lung irradiation and chemotherapy in comparison with partial lung irradiation in metastasizing, undifferentiated soft tissue XXXX ].

@entity1 @entity1665 @entity82 @entity242 @entity900 @entity358 @entity1576 @entity1260 @entity236
The poor prognosis of @entity1 with unresectable pulmonary metastases of soft @entity242 is well known. In order to evaluate the beneficial effect of radiotherapy, we have treated 44 @entity1 with pulmonary metastases of grade 3 soft @entity242 from 1980 to 1986. In 36 @entity1 the treatment volume was restricted to the single metastases up to a dose of 50 to 60 (9 to 10 Gy/week). The survival rate at one year was 18% and at two years 6%. Eight @entity1 were treated with a combined regimen, consisting of @entity900 and @entity1260 with simultaneous whole lung irradiation. Irradiation was performed with 8 or 16 MV photons at a hyperfractionation of 2 x 0.8 Gy/day (8 Gy/week). After a dose of 12 Gy, the single metastases were boosted up to 50 to 60 Gy, with a second course of chemotherapy. In six of eight @entity1 complete remissions were achieved, one @entity1 showed a partial remission. The survival rate at 27 months was 50%. The @entity1 with partial remission died from pulmonary progression at 23 months. One @entity1 died after twelve months from a loco-regional recurrence in the tonsillar fossa without evidence of @entity358 . Side effects included @entity1665 and moderate @entity236 approximately twelve days after each chemotherapy cycle. Pulmonary @entity82 was observed only at the high dose volume without @entity1576 . From these observations the conclusion is drawn that whole lung irradiation simultaneously with @entity900 and @entity1260 chemotherapy provides good palliative results without relevant morbidity in @entity1 with high grade unresectable pulmonary metastases of soft tissue @entity242 .
