[The dynamic changes of XXXX related cytokines during disease progression].

@entity1 @entity310 @entity1198 @entity1906 @entity4155 @entity379 @entity2533 @entity3646 @entity378 @entity688
OBJECTIVE: To study the dynamic changes of @entity378 related cytokines among @entity1 during the different courses of treatment, and to analyze their influences on the development and prognoses of @entity378 . METHODS: All @entity1 with active @entity378 were enrolled from Guangzhou, Shenzhen and Foshan @entity1906 control institutes. There were a total of 68 cases, 36 males and 32 females, aged 19 to 50 years [ average (30  9) years]. All the @entity1906 @entity1 received standard chemotherapy regimen of anti- @entity378 , and were divided into 2 groups: one completed treatment group (cured or clinically cured 38 cases) and 1 uncompleted treatment group (treatment failure or need to extend treatment, 30 cases). Peripheral blood serum at 0, 2, 6 month during the treatment from 68 @entity378 @entity1 were collected, and the concentration of @entity379 , @entity3646 , @entity4155 , @entity2533 , @entity310 and @entity688 were detected by ELISA tests. RESULTS: The concentration of @entity379 , @entity2533 and @entity3646 in all enrolled @entity1 showed significant decrease (from 23.2 ng/L to 22.3 ng/L, from 169.1 ng/L to 123.2 ng/L; 65.0 ng/L to 31.9 ng/L) (t=2.67, 2.35 and 3.41, P<0.05) along with the extension of treatment. @entity688 increased significantly (12.9 ng/L) in the uncompleted treatment group but declined significantly (5.38 ng/L) (P<0.05) in the completed treatment group at the end of 6 month. Meanwhile, @entity3646 decreased significantly (P<0.05) in the completed treatment group but no significant changes were observed in the uncompleted treatment group. @entity1198 /Th2 ( @entity379 / @entity3646 ) raised gradually in the completed treatment group (0 month <2 month <6 month, t=6.32, 6.03 and 5.85, P<0.05), while it was only at 6 month in the uncompleted treatment group (0 month <6 month, t=3.7, P<0.05). And the ratio of @entity1198 /Th2 in the completed treatment group was significantly higher than that in the uncompleted group treatment (P<0.05). CONCLUSION: It suggests that the changes of @entity1198 cytokines ( @entity379 , @entity2533 ) and the @entity1198 /Th2 balance play an important role in the pathogenesis, development and prognosis of @entity1906 . The suppression of @entity379 , @entity2533 or @entity1198 /Th2 balance may be an important factor influencing the prognosis of @entity1906 .
