Circulating hyaluronate: concentration in different vascular beds in XXXX .

@entity1 @entity15773 @entity4023 @entity17540
The plasma concentration of @entity17540 ( @entity4023 ; @entity15773 ) was measured in different vascular beds in order to determine regional kinetics of endogenous @entity15773 in fasting, supine subjects with normal (n = 6) or moderately decreased kidney function (n = 9). In both groups hepatic venous @entity15773 was significantly below the value obtained in plasma from pulmonary artery, inferior vena cava, and renal veins (P less than 0.001), giving a net hepato-splanchnic extraction ratio of @entity15773 about 33%. The concentration of @entity15773 in renal veins was significantly below that of the pulmonary artery and inferior vena cava (P less than 0.05). Average net renal extraction ratio of @entity15773 in normal kidneys was approximately 20%. Unilateral kidney function was assessed by 131I-hippuran renography, and the kidney with better function had a significantly higher extraction ratio when compared with the kidney with the lower function (P less than 0.025). @entity15773 was inversely correlated to glomerular filtration rate (r = -0.59, P less than 0.02). Assuming a plasma flow of 800 and 600 ml/min in normal liver and kidneys, respectively, the average normal plasma clearances of @entity15773 in these organs in the resting subject may be estimated to be 250 and 120 ml/min, respectively. The results indicate that the hepato-splanchnic region normally plays a major role in the biodegradation of endogenous circulating @entity15773 . The kidneys also eliminate the compound, presumably the low-molecular-weight fraction of the material. The results may explain abnormally high values of circulating @entity15773 in @entity1 with diseases in these organs.
