Staphylococcal enterotoxin IgE sensitization in late-onset severe XXXX in the elderly.

@entity1 @entity1712 @entity565 @entity102 @entity1793
BACKGROUND: @entity565 in the elderly (aged >=   65  years old) is a significant concern with high morbidity, but the pathophysiology remains unclear particularly in late-onset @entity565 . Recent studies suggest staphylococcal enterotoxin IgE (SE-IgE) sensitization to be a risk factor for @entity565 in general populations; however, the associations have not been examined in late-onset elderly @entity565 . OBJECTIVE: We aimed to examine the associations of @entity1793 with late-onset @entity565 in the elderly, using a database of elderly @entity565 cohort study. METHODS: A total of 249 elderly @entity1 with @entity565 and 98 controls were analysed. At baseline, @entity1 were assessed for demographics, atopy, induced sputum profiles and comorbidities including @entity102 ( @entity102 ). Serum total IgE and SE-IgE levels were measured. @entity565 severity was assessed on the basis of @entity565 outcomes during a 12-month follow-up period. RESULTS: At baseline, serum SE-IgE concentrations were significantly higher in @entity1 with @entity565 than in controls [median 0.16 (interquartile range 0.04-0.53) vs. 0.10 (0.01-0.19), P  <  0.001]. Elderly @entity565 @entity1 with high SE-IgE levels had specific characteristics of having more severe @entity565 , sputum @entity1712 and @entity102 , compared to those with lower SE-IgE levels. In multivariate logistic regression analyses, the associations between serum SE-IgE concentrations and severe @entity565 were significant, independently of covariables [SE-IgE-high (>=   0.35  kU/L) vs. negative (<  0.10  kU/L) group: odds ratio 7.47, 95% confidence interval 1.86-30.03, P  =  0.005]. Multiple correspondence analyses also showed that high serum SE-IgE level had close relationships with severe @entity565 , @entity102 and sputum @entity1712 together. CONCLUSIONS AND CLINICAL RELEVANCE: This is the first report on the significant associations of @entity1793 with late-onset @entity565 in the elderly, particularly severe @entity1712 with @entity102 comorbidity. Our findings indicate a potential implication of SE in the high morbidity burden of elderly @entity565 and suggest clues to the pathogenesis of severe late-onset @entity1712 in the elderly.
