Association of @entity15787 Cytokine With Severity of Primary Sj  gren XXXX .

@entity1 @entity2194 @entity15787 @entity936 @entity751
PURPOSE:: @entity15787 plays an important role in primary @entity751 ( @entity751 ) pathogenesis. The purpose of this study was to evaluate @entity15787 expression in tears and the conjunctiva and to analyze the impact of @entity15787 on primary @entity751 dry eyes. METHODS:: Eighty subjects were enrolled in this study: 30 @entity1 with @entity936 (30 eyes); 30 @entity1 with non- @entity751 dry eye (30 eyes), and 20 normal controls. Tear @entity15787 levels were measured by flow cytometry, and @entity15787 gene expression in the conjunctiva from impression cytology was evaluated by quantitative polymerase chain reaction. @entity2194 Index, tear film breakup time, Schirmer I test, and ocular surface staining scores were obtained for all @entity1 . RESULTS:: Primary @entity751 dry eyes had significantly higher tear @entity15787 levels than non- @entity751 dry eyes and normal controls (P < 0.01). In addition, @entity15787 gene expression in the conjunctiva was also higher in primary @entity751 dry eyes than in non- @entity751 dry eyes and normal controls (P < 0.01). However, there were no significant differences in @entity15787 expression in tears and the conjunctiva between non- @entity751 dry eyes and controls. The tear @entity15787 level was significantly correlated with ocular surface stain scores (r = 0.54, P < 0.01) and Schirmer I test values (r = -0.23, P < 0.05) in primary @entity751 dry eyes. CONCLUSIONS:: Our findings suggest that severity of @entity936 is associated with @entity15787 .
