CSF in XXXX . Studies on blood-brain barrier function and intrathecal protein synthesis.

@entity1 @entity2104 @entity69 @entity195
Serum and cerebrospinal fluid (CSF) from 22 ambulatory and 10 institutionalised @entity1 with @entity195 ( @entity195 ) and 22 age-matched controls were assayed nephelometrically for concentrations of IgG, IgA, IgM, @entity2104 , @entity69 , prealbumin and albumin. The CSF/serum ratio and index were calculated for each protein. In the CSF of ambulatory patients IgG, @entity69 and albumin were elevated while the institutionalised @entity1 had higher IgG and IgA levels compared to the controls. The CSF @entity2104 was elevated in institutionalised @entity195 @entity1 compared to those who were ambulatory. The CSF/serum ratio for albumin was elevated in both groups. An increase in the IgG ratio was also found in both groups. The ratios for @entity2104 and prealbumin were markedly increased in the institutionalised @entity1 . CSF indices gave no evidence for increased intrathecal synthesis of any of the proteins investigated. The increased CSF/serum ratios for IgG and albumin and also the higher CSF albumin in @entity1 with @entity195 suggest an increased blood-brain barrier permeability in this disease. The high prealbumin ratio may be related to amyloidogenesis often present in @entity195 .
