Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a XXXX @entity64 Model.

@entity1 @entity64 @entity548 @entity63 @entity35
BACKGROUND AND PURPOSE: Reperfusion-associated @entity548 ( @entity548 ) is an important complication of recanalization therapy. A method to identify @entity64 victims that may undergo @entity548 will improve the @entity1 selection and safety of this treatment. In this study, we determined the relationship between timing of reperfusion and the frequency and severity of @entity548 , and whether very early dynamic contrast-enhanced (DCE) imaging predicts the occurrence of reperfusion-associated @entity548 in a model of experimental @entity64 . METHODS: Intraluminal suture occlusion of the middle cerebral artery was used to produce transient @entity63 in male @entity35 (n = 50). Reperfusion was performed by withdrawal of the occluding filament after 3 (n = 10), 4 (n = 10), 5 (n = 10), 6 (n = 10), or 7 (n = 10) hours. Magnetic resonance imaging studies were performed before reperfusion using DCE, susceptibility-weighted imaging, diffusion-weighted imaging, and T2- and T1-weighted imaging. Follow-up magnetic resonance imaging and histological studies were performed at 24 hours. RESULTS: Hemorrhagic transformation occurred by 24 hours after injury in 8 of 50 animals. The @entity548 rate increased with prolonged @entity63 duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed @entity548 by 24 hours. Statistically significant differences in the BBB permeability parameters (P < 0.05) between the @entity548 group and non- @entity548 group were detected by DCE imaging. There were also statistically significant differences (P < 0.05) between the @entity548 area and adjacent @entity548 area. Among the permeability parameters, subcortex rK was the most sensitive and specific predictor of @entity548 . CONCLUSIONS: The results suggest that the use of quantitative BBB measurements may further improve early prediction and identification of @entity548 . The DCE parameters were the sensitive early independent predictor of reperfusion-associated @entity548 .
