Interaction between periodontal disease and systemic secondary amyloidosis: from @entity32 to XXXX .

@entity1 @entity32 @entity827 @entity2783 @entity233 @entity5 @entity548 @entity2521
BACKGROUND: It has become increasingly clear in recent years that periodontal disease can cause a dramatic increase in the levels of markers of systemic @entity32 , and that periodontal treatment can result in reduction in the levels of these markers. We have previously shown that the prevalence of moderate to severe @entity2521 was significantly higher in @entity1 with @entity827 ( @entity827 ) with @entity2783 than in @entity1 with @entity827 without @entity2783 . Thus, the aim of this study is to investigate if chronic @entity2521 is associated with secondary @entity2783 in the Black Sea region of @entity233 . METHODS: A total of 112 @entity1 with biopsy-proven secondary @entity2783 (59 @entity1 with @entity827 , 40 @entity1 who were either chronically infected or had @entity5 , 13 @entity1 with @entity2521 ) and 22 healthy subjects, were included in this study. Periodontal health and disease were evaluated using gingival index (GI), @entity548 index (PBI), plaque index (PI), and periodontal disease index (PDI). The concentrations of serum acute phase reactants (APRs) were measured at baseline and at 4 to 6 weeks after completion of the non-surgical periodontal therapy. RESULTS: The prevalence of moderate to severe @entity2521 was 47.5% in @entity1 with @entity827 , 72.5% in @entity1 who were either chronically infected or had @entity5 , and 84.6% in @entity1 with @entity2521 . Serum levels of APRs in @entity1 with @entity2783 were reduced significantly after non-surgical periodontal therapy (P <0.01). CONCLUSIONS: Periodontitis can increase the levels of APRs and potentiate the development of @entity2783 either by themselves or association with traditional factors, such as @entity827 and other chronic inflammatory diseases. Thus, preventing or treating @entity2521 might prevent or at least alleviate the progression of @entity2783 . Periodontal evaluation should be performed as part of a medical assessment and considered as an etiologic factor for secondary @entity2783 .
