Continuous Positive Airway Pressure Treatment Reduces Mortality in Elderly XXXX with Moderate to Severe Obstructive Severe Sleep Apnea: A Cohort Study.

@entity1 @entity6 @entity27 @entity204 @entity65
@entity27 ( @entity27 ) is much more prevalent in older @entity1 than in middle-aged or young populations, and has been associated with @entity65 . Continuous positive airway pressure (CPAP) is the first-line therapy for @entity27 , but its long-term clinical benefit in the elderly is unclear. Here, we carried out a prospective cohort study to explore the survival rate and incidence of cardiovascular events in elderly @entity1 with moderate to severe @entity27 who did or did not receive CPAP treatment. The study included 130 @entity1 (104 male, 26 female; mean age: 77.8    6.2 years) who were followed up for a mean of 5    2.54 years (range, 1-8 years). Thirty-six @entity1 received CPAP and 88 had no CPAP. The results showed that mortality in the untreated group (21.6%) was significantly higher than in the CPAP group (5.6%). Kaplan-Meier survival analysis showed that the survival rate in the CPAP group was 94.4%, which was markedly higher than the rate of 78.4% in the untreated group. The incidence of cardiovascular events was 13.9% in the CPAP group and 55.7% in the untreated group. The present study provides evidence that CPAP can reduce mortality in older @entity1 with moderate to severe @entity27 , and lead to a good long-term prognosis. The study also indicates that @entity204 in older @entity27 @entity1 is associated with @entity65 and @entity6 .
