Can @entity5 regression grade influence survival outcome in ypT3 XXXX ?

@entity1 @entity82 @entity22576 @entity66 @entity17199 @entity5 @entity17198 @entity1349
PURPOSE: Locally advanced @entity5 (LARC) @entity1 achieving ypT3 status following neoadjuvant chemoradiation are considered to have poor response with minimal downstaging. However, @entity5 cell amounts vary in the subserosa/perirectal fat. Tumor regression grading (TRG) is an evaluation method based on the proportion of @entity82 and @entity5 cells. The aim of this study is to assess the influence of TRG in ypT3 @entity5 @entity1 who received neoadjuvant chemoradiation. METHODS: We retrospectively reviewed 325 LARC @entity1 who received neoadjuvant chemoradiation and surgery. TRG scores were recorded by two independent pathologists. Among these @entity1 , 143 were staged as ypT3. We analyzed TRG and other clinicopathological factors and their relationship with survival outcome including @entity1349 ( @entity1349 ) and @entity66 ( @entity66 ). RESULTS: Among 143 ypT3 @entity1 , 44 (30.8  %) were @entity17198 , 84 (58.7  %) were @entity17199 and 15 (10.5  %) were @entity22576 . Seventy-nine (55.3  %) of these @entity1 had metastatic lymph nodes. In univariate analysis, TRG was not associated with @entity66 ( @entity17199 vs @entity17198 , P  =  0.852; @entity22576 vs @entity17198 , P  =  0.593) or @entity1349 ( @entity17199 vs @entity17198 , P  =  0.977; @entity22576 vs @entity17198 , P  =  0.665). Palliative surgery (HR 3.845; 95  % CI 1.670-8.857; P  =  0.002) and metastatic lymph nodes after surgery (HR 5.894; 95  % CI 1.142-3.48; P  =  0.015) were significantly associated with decreased @entity66 , while palliative surgery was the only factor associated with worse @entity1349 (HR 6.011; 95  % CI 2.150-16.810; P  =  0.001). Palliative surgery (HR 3.923; 95  % CI 1.696-9.073; P  =  0.001) and metastatic lymph nodes (HR 2.011; 95  % CI 1.152-3.512; P  =  0.014) also showed prognostic significance for @entity66 in multivariate analysis. CONCLUSIONS: @entity5 cells evaluated by TRG score after neoadjuvant chemoradiation do not influence survival outcome in ypT3 @entity5 @entity1 . However, lymph node status is a significant prognostic factor in ypT3 @entity1 .
