Polymorphisms in @entity32 associated genes @entity13695 and @entity650 are associated with bone properties in young @entity1 and XXXX in elderly.

@entity1 @entity650 @entity51698 @entity32 @entity174 @entity70599 @entity604 @entity13695 @entity79 @entity10327 @entity3899 @entity6864 @entity1851
PURPOSE: @entity10327 and @entity13695 encode @entity3899 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity10327 and @entity13695 can activate the expression of the potent pro-inflammatory cytokine @entity650 , and produce endogenous ligands for @entity6864 . In this study, polymorphisms in @entity10327 , @entity13695 , @entity650 and @entity6864 were investigated for association with bone properties in young and elderly Swedish @entity1 . METHODS: Three SNPs in @entity10327 , five in @entity13695 , one each in @entity650 and @entity6864 were genotyped in the cohorts PEAK-25 (n=1061 @entity1 ; all 25y) and OPRA (n=1044 @entity1 ; all 75y). @entity79 ( @entity79 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity79 ( @entity79 ) in PEAK-25; @entity604 , @entity174 incidence and serum @entity1851 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity1 @entity13695 ( @entity51698 ) was associated with CRP levels (p=0.004) and incident @entity174 of any type (p=0.014), although not with @entity79 or ultrasound. In young @entity1 , carrying the common T allele (ALOX 15 @entity70599 ) was associated with lower QUS values (p=0.002-0.006). The @entity650 SNP was associated with lower @entity79 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity79 was not associated with variation in any gene. Variants in the @entity10327 and PPARy were not associated with @entity79 in either cohort. CONCLUSIONS: This study suggests that variation in @entity32 related genes @entity13695 and @entity650 was associated with bone microarchitecture and density in young adult @entity1 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity32 and incident @entity174 .
