Studies on an animal model of XXXX .

@entity7956 @entity167 @entity988 @entity750 @entity35 @entity1068
Past and ongoing studies indicate that the selectively bred P line of @entity35 satisfies virtually all the suggested criteria for an animal model of @entity988 . They attain pharmacologically active levels of BAC and develop tolerance and physical dependence with voluntary oral @entity1068 ingestion, while in the free-feeding state. @entity1068 is positively reinforcing to the @entity7956 and consumption appears to be directed by the post-ingestive, pharmacological effects of @entity1068 , as revealed by the intragastric self-administration studies. Some interesting differences between the P and the NP lines have been uncovered. They differ in the content of @entity750 in several brain regions and they respond differently to @entity1068 . The @entity7956 develop acute tolerance to sedative-hypnotic doses of @entity1068 more rapidly than do the NP @entity35 , and they exhibit stimulation with low doses of @entity1068 . These differences suggest hypotheses on mechanisms underlying @entity167 -seeking behavior which can now be tested experimentally. It should be emphasized, however, that the described findings are the product of but a single genetic experiment. Clearly, replication is needed, and we are currently doing this, using a better defined, heterogeneous stock of @entity35 . This one experiment, however, has demonstrated the feasibility of developing animal models of @entity988 and offers hope that the genetic and biological basis of @entity167 -seeking behavior can be explored in the laboratory. The screening and testing of pharmacological agents able to deter @entity167 -seeking behavior is an obvious practical application of this model.
