High early case @entity3329 after @entity64 in Poland: exploration of possible explanations in the International XXXX Trial.

@entity1 @entity3329 @entity64 @entity301 @entity117 @entity1151 @entity51 @entity955 @entity8987 @entity204 @entity65
PURPOSE: To determine why Polish @entity1 included in the International @entity64 Trial (IST) had a higher early case @entity3329 than @entity1 from other countries. METHODS: Of 19,435 @entity1 randomised to IST, 17,370 had CT or autopsy-confirmed @entity64 . We compared the baseline clinical state and 14-day case @entity3329 of @entity1 randomised in Polish centres with those from all other IST countries. We examined: age, gender, presence of @entity955 ( @entity955 ), conscious level, @entity51 , cause of @entity204 and @entity117 use in the 3 days before @entity64 . RESULTS: In Poland, the 14-day case @entity3329 rate was significantly higher than in other IST countries (13% vs. 9.6%; odds ratio, OR, 1.5, 95% confidence interval, CI, 1.2-1.9). In Poland, a significantly higher proportion of @entity204 was attributed to @entity301 (2.5% vs. 0.7%) and @entity1151 (1.0% vs. 0.4%). Polish @entity1 had higher percentage of @entity955 and drowsiness, but were younger. When these factors were adjusted for, Polish @entity1 still had approximately a 57% higher risk of @entity204 within 14 days compared with other countries. A logistic regression analysis revealed that an increased risk of @entity204 within 14 days in Poland compared to other IST @entity1 was present among @entity1 younger than 75 years (OR 1.7; 95% CI 1.3-2.4), females (OR 1.8; 95% CI 1.3-2.5), @entity1 who were alert at onset (OR 2.4; 95% CI 1.7-3.4), with partial anterior circulation syndrome (PACS) (OR 2.0; 95% CI 1.4-2.8) or @entity8987 ( @entity8987 ) (OR 2.4; 95% CI 1.1-5.0) and without @entity955 (OR 1.8; 95% CI 1.3-2.4). Polish @entity1 were less likely to have been on @entity117 before their @entity64 than other countries (7.6% vs. 20.8%). CONCLUSION: The 14-day case @entity3329 was significantly higher in Poland than in other countries in IST. Part of the increase was due to greater @entity64 severity in the Polish @entity1 . However, differences persisted even after adjustment for baseline @entity64 severity. Several factors may have contributed the excess: poor attention to treatment of @entity65 , less attention to treatment of secondary complications of @entity64 and some other--as yet unidentified--factor specific to Poland.
