Prediction of XXXX clearance using condition correction factors.

@entity1 @entity2544 @entity3416
The predictive ability of different mathematical manipulations of condition correction factors in estimating total body clearance of @entity2544 in acutely ill hospitalized @entity1 was evaluated. Fifty acutely ill @entity1 who were treated with constant @entity3416 infusions were evaluated. Twenty-one @entity1 were evaluated prospectively. Initial serum @entity2544 concentrations were ordered, and second concentrations were obtained at steady state. Twenty-nine @entity1 were evaluated retrospectively and were included if two steady-state serum @entity2544 concentrations had been obtained. Each condition correction factor was determined by calculating the predicted normal clearance using a literature-derived clearance value and dividing it into the actual clearance obtained. The FDA condition correction factors were obtained by dividing the @entity2544 dose recommended for @entity1 with a particular disease by the dose recommended for a normal @entity1 . Pearson correlation coefficients for 15 mathematical manipulations were used to examine the relationship between the predicted clearance and actual clearance. The predictability of @entity2544 clearance using the mathematical manipulations decreased as the number of condition correction factors increased. The mean actual clearance for four @entity1 with no condition correction factors was only 2% greater than the mean standard clearance found in a previous study. The use of 0.041 L/hr/kg as a standard clearance appears justified for calculating initial @entity2544 dosages in all @entity1 . @entity1 with only one condition correction factor may use this factor to adjust dosage, but when more than one factor is present, the use of the other manipulations studied may result in either subtherapeutic or toxic serum concentrations.
