Effect of the XXXX on the concentration of serum complement components.

@entity1 @entity7676 @entity4988 @entity6300 @entity4 @entity628 @entity19459 @entity134 @entity1985 @entity631 @entity1660
The concentration of 12 component and four control proteins of the complement system was measured in serum from 43 @entity1 with a @entity1985 , which subsequently proved to be @entity134 -responsive, and from 13 @entity1 with @entity628 ( @entity628 ) and was compared with values from 197 normal subjects. Of classical pathway complement components, 40% of @entity1 had low @entity6300 levels and 20%, low C2 levels. Mean serum levels of @entity1660 , C4, @entity19459 , and @entity7676 were elevated. Of alternative pathway components, factors B and I were low in one third, while levels of C3 and H were commonly elevated. Of the terminal components, only C8 and C9 were low. In five @entity1 with @entity628 with @entity4988 without @entity4 , all component levels were normal. With the exception of @entity6300 , @entity1660 , and C8, high molecular weight (mol wt) components were in high concentration and low mol wt components in low concentration. The three exceptions may be explained by the subunit structure of C1 and C8. From a practical standpoint, the study indicates that @entity4 @entity1 with a @entity1985 may have low serum levels of @entity6300 and C2, simulating classical pathway complement activation such as commonly occurs in @entity631 . However, low levels of C4, and possibly @entity1660 , can be used as indicators of classical pathway activation since their levels are not reduced by a @entity1985 .
