Heat shock modulates the expression of the @entity3 associated gene MTS1 and proliferation of XXXX and @entity1 @entity5 cells.

@entity1 @entity2284 @entity19 @entity5 @entity18402 @entity876 @entity3 @entity141 @entity221 @entity320
@entity18402 is a @entity3 -associated gene of the S-100 gene family and codes for a @entity141 -binding protein. It is highly expressed in @entity19 and @entity1 @entity5 of high invasive and metastatic potential. Recent work has shown that the @entity18402 protein might be involved in cell cycle regulation. An upregulation of its expression drives cells into the S phase, together with an enhanced expression of @entity876 phosphoprotein, which has led to the suggestion that mtsl protein might be sequestering @entity876 thereby abrogating the G1-S checkpoint control normally exerted by @entity876 . Preliminary studies showed that expression of @entity18402 is downregulated by @entity221 . We present evidence that in @entity19 BL6 @entity320 cells and @entity1 HUT cells that @entity221 downregulates the @entity18402 gene. It is also downregulated in heat-resistant variants of the B16 @entity320 and HUT cells. In parallel, there is a decrease in the size of the S phase fraction and an increase in the doubling time of cells. Cell subjected to @entity221 show an 2- to 3.5-fold increase in the expression of @entity2284 which has been shown to possess a proliferation inhibitory action. It is postulated that a complete regulatory loop involving mtsl, @entity876 , and @entity2284 might be involved in cell proliferation.
