Weight-based hypoglycaemia treatment protocol for adults with Type 1 XXXX : a randomized crossover clinical trial.

@entity1 @entity2749 @entity413 @entity6
AIM: To determine whether a weight-based hypoglycaemia treatment using 0.3  g/kg (or 0.2  g/kg) @entity413 effectively treats adults with @entity6 compared with an internationally recommended 15-g treatment. METHODS: @entity1 with frequent hypoglycaemia were recruited from hospital-based @entity6 clinics. The treatment for each @entity2749 , defined as capillary @entity413 <4.0  mmol/l, was randomly assigned to one of three protocols: 0.2  g/kg, 0.3  g/kg, or 15  g, using Dextro(TM) @entity413 tablets (Dextro Energy, Krefeld, Germany). Each @entity1 received each treatment in random order for up to 15 hypoglycaemic episodes. Capillary @entity413 was re-tested 10  min after treatment, with a repeat dose if still < 4  mmol/l. RESULTS: The study recruited 34 @entity1 aged 22-71  years, whose mean (sd) BMI was 25.2 (3.1) kg/m(2) and HbA1c 63 (10.4) mmol/mol [7.9 (0.9)%]. Two @entity1 withdrew because they did not like the taste of the Dextro tablets and one was excluded because they used their own @entity413 preparation. Unadjusted for clustering within @entity1 , the mean (sd) capillary @entity413 after 10  min was 4.67 (1.25) mmol/l for 0.3  g/kg (141 episodes), 4.29 (0.94) mmol/l for 0.2  g/kg (132 episodes), and 4.37(0.99) mmol/l for 15  g (136 episodes). Capillary @entity413 , adjusted for clusters and baseline, was higher after 10  min for 0.3  g/kg @entity413 compared with 15  g @entity413 ; a difference of 0.26 (95% CI 0.04-0.48) mmol/l (P  =  0.02), but not for 0.2  g/kg; -0.07 (95% CI -0.29-0.16) mmol/l (P  =  0.56). Capillary @entity413 for only three hypoglycaemic episodes rose above 8  mmol/l. CONCLUSIONS: A weight-based protocol of 0.3  g/kg @entity413 appears more effective for treating symptomatic hypoglycaemia in adults with Type 1 @entity6 than either the most common current recommendation of 15  g @entity413 or a 0.2  g/kg @entity413 dose.
