Irritable Bowel Syndrome and XXXX : A Systematic Review and Meta-analysis.

@entity1 @entity294 @entity1744 @entity3178
BACKGROUND _ AIMS: @entity1 with @entity3178 and @entity1 with @entity1744 ( @entity1744 ) present with similar symptoms. We examined the association between @entity1744 and @entity3178 in a systematic review and meta-analysis. METHODS: We searched the medical literature to identify cross-sectional surveys or case-control studies reporting the association between @entity3178 and @entity1744 in 50 or more unselected adult @entity1 . We recorded the prevalence of @entity1744 symptoms in @entity1 with histologically confirmed @entity3178 , or the prevalence of histologically confirmed @entity3178 in @entity1 with @entity1744 . Data were pooled using a random-effects model; the association between @entity3178 and @entity1744 was summarized using an odds ratio (OR) with a 95% confidence interval (CI). RESULTS: The search strategy identified 3926 citations, of which 10 were eligible for our analysis. The pooled prevalence of @entity1744 in @entity1 with @entity3178 was 33.4% (95% CI, 31.5%-40.6%), but was not significantly higher in @entity1 with @entity3178 than in @entity1 with @entity294 (OR, 1.39; 95% CI, 0.43-4.47). In 3 cross-sectional surveys, the pooled OR for @entity3178 in @entity1 with @entity1744 , compared with other @entity1 with @entity294 , was 0.68 (95% CI, 0.44-1.04). In 4 case-control studies the prevalence of @entity1744 in @entity1 with @entity3178 was significantly higher than in asymptomatic controls (OR, 5.16; 95% CI, 1.32-20.2). CONCLUSIONS: Based on a meta-analysis, one third of @entity1 with @entity3178 reported symptoms compatible with @entity1744 , but the prevalence of @entity1744 was no higher than in other @entity1 with @entity294 . The odds of @entity3178 were no higher in @entity1 with @entity1744 compared with other @entity1 with @entity294 . The value of routine colonoscopy and biopsy to exclude @entity3178 in @entity1 with typical @entity1744 symptoms, unless other risk factors or alarm symptoms are present, remains uncertain.
