A retrospective analysis of forty-six cases of herpes simplex XXXX seen in Glasgow between 1962 and 1985.

@entity1 @entity778 @entity410 @entity198 @entity428 @entity772 @entity693 @entity683 @entity2026 @entity854 @entity911 @entity1315 @entity7592 @entity10 @entity2798
The clinical features, investigative profiles and outcome of 46 @entity1 with biopsy or autopsy-proven herpes simplex @entity198 admitted to the Institute of Neurological Sciences, Glasgow between 1962 and 1985 were analysed retrospectively. The protean presenting symptoms and signs included a history of a @entity683 (48 per cent), rapid onset of @entity10 , clouding of consciousness and @entity911 (52 per cent), @entity693 (65 per cent), @entity428 (33 per cent), deep @entity772 (35 per cent), @entity2798 or @entity2026 (46 per cent), focal neurological signs (89 per cent), and @entity410 (61 per cent). When @entity410 occurred they were almost always focal. The electroencephalogram was the most useful diagnostic test being abnormal in all cases, the majority showing focal changes in one or other hemisphere. Of the neuroradiological procedures employed, computerized tomographic and isotope brain scanning most frequently demonstrated @entity854 in one or both @entity1315 . Midline shift was seen in half the cases. The cerebrospinal fluid was abnormal in every case but was not diagnostic. Cerebral biopsy of one temporal lobe was performed in 40 cases and a positive diagnosis of @entity7592 was made in 37 of these. Herpes simplex virus was isolated from the brains of 29 of the 40 cases in which the procedure was attempted, but immunofluorescence assays for antigens to @entity778 were only positive in 11 out of 25 cases. Serological assays showed a greater than four-fold rise in the anti- @entity778 antibody titre in 13 out of 22 @entity1 tested.(ABSTRACT TRUNCATED AT 250 WORDS)
