XXXX --experience of a standardized diagnostic programme in the Swedish prospective study.

@entity1 @entity1369 @entity1911 @entity5 @entity700 @entity701 @entity652 @entity1063 @entity4304
OBJECTIVE: To report the 5-year experience of a diagnostic programme for @entity700 with special emphasis to diagnose hormonally active and @entity5 . DESIGN: A prospective study in which new cases of @entity700 in Sweden have been evaluated by a standardized diagnostic protocol between January 1996 and July 2001. SETTING: Thirty-three different Swedish hospitals have contributed with cases. SUBJECTS: A total of 381 @entity1 (217 females, 164 males) with @entity700 were studied. INTERVENTIONS: Diagnostic procedures were undertaken according to a standardized programme. Operation was recommended if the incidentaloma had a size of more than 3-4 cm or if there was a suspicion of a hypersecreting @entity5 . MAIN OUTCOME MEASURES: The size of the incidentaloma, clinical characteristics of the @entity1 and results of biochemical diagnostic tests were registered. RESULTS: The median age of the @entity1 was 64 years (18-84 years), and the median size of the incidentalomas was 3 cm (1-20 cm). A total of 85(22%) @entity1 were operated. Twenty of these @entity1 were diagnosed with a benign hypersecreting @entity5 and 14 with a @entity5 . Fourteen of 15 operated @entity1 with diagnosed @entity1911 had elevated 24-h urinary @entity1063 and all of the @entity1 operated because of a biochemical suspicion of @entity1369 or @entity701 hypersecretion (n = 6) were found to have @entity652 . Of the 14 operated @entity1 with @entity5 , 10 were @entity4304 (median size 10 cm; range 4-16 cm). In a multiple logistic regression model, incidentaloma size was significantly associated with the risk of a @entity5 (P = 0.009), and there was a tendency of an association between age/male sex and the risk of a @entity5 (both, P = 0.07). CONCLUSION: In this Swedish multicentre study of 381 cases with @entity700 , 5% had benign hypersecreting @entity5 and nearly 4% had @entity5 . The results of the biochemical diagnostic tests used had a high compatibility with the histological diagnosis found at operation in the @entity1 with hypersecreting @entity5 . @entity5 size, male gender and high age were predictive for the risk of a @entity5 . A follow-up of the @entity1 is warranted in order to establish whether there are undiscovered cases of malignant or hypersecreting @entity5 amongst the nonoperated @entity1 .
