[Meta-analysis of application value of sentinel lymph node biopsy in early-stage XXXX ].

@entity1 @entity5 @entity957 @entity1600 @entity189
OBJECTIVE: To systematically review the clinical value of sentinel lymph node biopsy (SLNB) in diagnosis of @entity1600 in early-stage squamous cell @entity189 . METHODS: Cochrane library, biomedical database (EMbase), PubMed, China national knowledge internet (CNKI), Wang Fang database,   Gynecologic Oncology  ,   National Medical Journal of China   and   Chinese Journal of Obstetrics and Gynecology   were searched for literatures from 1990 to 2014 concerning SLNB application in early-stage @entity957 . Literatures were filtrated according to inclusive and exclusive criteria. Meta Disc 1.4 software was used for meta-analysis. RESULTS: A total of 2 459 literatures were obtained, out of which 29 were eligible for analysis, including 28 in English and 1 in Chinese. Twenty-three studies were prospective and 6 were retrospective, including 1 371 @entity1 with early-stage squamous cell @entity189 . The sensitivity of SLNB for diagnosis of @entity1600 in early-stage @entity5 ranged from 66.7% to 100%, and the specificity were 100% in all studies. No significant heterogeneity was found among the results of enrolled studies (I(2)=12.8%, P=0.270). The data were pooled by fixed effect model, and the pooled sensitivity and specificity were 0.94 (95%CI: 0.91-0.96) and 1.00 (95%CI: 0.99-1.00), respectively. The calculated area under curve (AUC) of summarized Receiver Operating Characteristic (ROC) was 0.987 0. Subgroup analysis showed that the pooled sensitivity of SLNB were 0.92 (95%CI: 0.85-0.97) and 0.94 (95%CI: 0.91-0.97) in studies using single and combined tracers, respectively, and that they were 0.93 (95%CI: 0.90-0.96) and 0.97 (95%CI: 0.90-1.00) in studies with and without ultra-staging techniques, respectively. CONCLUSIONS: SLNB is a highly accurate technique for diagnosis of @entity1600 in early-stage squamous cell @entity189 . The sensitivity and specificity are similar in SLNBs using different techniques.
