Low power argon laser-induced thermal therapy for subcutaneous @entity8270 in XXXX using spherical gold nanoparticles.

@entity39 @entity19 @entity5 @entity189 @entity3503 @entity8270
The present study examines the feasibility of a low power argon laser-induced thermal therapy to @entity8270 , employing a direct administration of spherical gold nanoparticles (GNPs). This modality utilizes the advantage of strong surface plasmon resonance exhibited by spherical GNPs in the visible range. @entity8270 were grown in female balb @entity19 by subcutaneous injection of Ehrlich ascites @entity189 cells. GNPs with an average diameter 13 +/- 1.2 nm and optical density (ODlambda:518 nm = 3) were directly injected within the @entity5 interstitium. @entity5 were then illuminated with a continuous-wave (CW) @entity3503 ion laser with irradiance 55 mW cm-2 for 45 min. All laser-GNPs treated @entity5 exhibited a significant suppression in @entity5 growth throughout 15 days. On the contrary, sham-treated group (laser treatment without GNPs injection) and control group (neither laser nor GNPs treatment) showed a progressive increase in @entity5 growth during the same period. Histopathological examination demonstrated extensive @entity39 percentage in laser-GNPs treated group (90%) in comparison with sham (35%) or control group (3-7%). A wide-angle X-ray scattering also revealed detectable changes in @entity5 protein structure exposed to both laser and GNPs. It can be concluded from this study that the intense surface plasmon resonance exhibited by spherical GNPs in the visible range could be very useful as a noninvasive technique for photothermal therapy of skin or near-surface @entity5 that need much less laser energy and lower concentrations of GNPs.
