The Influence of Intraoperative Factors and Histopathological Staging on the Performance of Sentinel Node Biopsy in XXXX .

@entity5 @entity1 @entity694
BACKGROUND: The aim of this study was to assess sentinel node biopsy (SNB) results in @entity694 ( @entity694 ) regarding intraoperative staging of the disease and pathological @entity5 features. MATERIAL AND METHODS: The study was conducted on the basis of 132 SNBs in @entity694 . The elements of intraoperative staging of the disease and pathological @entity5 features were compared with accur--acy, sensitivity and false negative results of SNB in @entity694 by means of ROC curves and the tests for population proportions. RESULTS: ROC curve analysis did not reveal any statistical significance for @entity5 measurements (all p > 0.05). Statistically significantly worse results in sensitivity (not in accuracy) were achieved for @entity5 in comparison with T2 @entity5 (83% vs 89%, p = 0.0066). Statistically significantly worse results in accuracy (not in sensitivity) of the method were obtained in the cases of involved lymph nodes (78% vs 100%, p < 0.0001), infiltration of the lymph node capsule (80% vs 97%, p = 0.0023) and infiltration of the perinodal tissue (73% vs 97%, p = 0.0002). The analyses of SNB sensitivity and accuracy in combination with other features showed no statistical significance (all p > 0.05). CONCLUSIONS: The sensitivity of the method is significantly worse for @entity5 with deeper infiltration of intestinal wall. The presence of nodal metastases, lymph node capsule and perinodal invasion significantly affects the accuracy results of SNB in @entity694 . The problem of qualifying @entity1 for the procedure in regard to the other analysed features, however, remains open and requires further analysis.
