Critical analysis of the 2010 TNM classification in @entity1 with @entity150 : Influence of XXXX burden.

@entity1 @entity3329 @entity1600 @entity189 @entity150 @entity1349
OBJECTIVES: In 2010, a new TNM staging system was published by American Joint Committee on Cancer, changing the nodal classification to include the presence of common iliac lymph node (LN) involvement as N3 category. The objective of this study was to define the capability of the current TNM nodal classification to separate @entity1 with different prognostic stages and to evaluate the effect of @entity1600 burden. METHODS AND MATERIALS: A total of 93 @entity1 with metastatic LNs after radical cystectomy and extended LN dissection for @entity189 of the bladder between 1999 and 2012 were included. The median follow-up was 21.5 months. The correlation between N3 and indicators of @entity1600 burden was analyzed using the Spearman correlation coefficient. @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) analysis was performed using the Kaplan-Meier and Cox proportional hazards methods. RESULTS: The presence of N3 disease was associated with higher number of metastatic LNs (7 vs. 2, P<0.01); however, this was highly variable and correlation coefficients between common iliac metastatic LNs and other @entity3329 burden indicators demonstrated weak association (0.39-0.63). @entity1 with N1 lesions were found to have a distinct @entity1349 and @entity1349 (P<0.01 and P = 0.01, respectively). A trend toward worse @entity1349 (P = 0.07) and @entity1349 (P = 0.08) was observed in @entity1 with N3 lesions. However, no difference in @entity1349 or @entity1349 was found between @entity1 with N2 and N3 lesions (P = 0.83 and 0.50, respectively). CONCLUSIONS: The N3 category in the current TNM classification defines a group of @entity1 with high but heterogeneous disease burden. This may be the explanation for its lack of prognostic stratification when compared with N2 category @entity150 .
