The Vasodilator Effect of a Cream Containing 10% @entity4746 and 15% XXXX on Random-Pattern Skin Flaps in @entity35 .

@entity4746 @entity27178 @entity35 @entity39
BACKGROUND: It is still difficult to prevent partial or full-thickness flap @entity39 . In this study, the effects of a cream containing @entity4746 and @entity27178 on the viability of randompattern skin flaps were studied. METHODS: Forty female @entity35 were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing @entity4746 and @entity27178 was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap @entity39 was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. RESULTS: According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). CONCLUSIONS: Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.
