XXXX polymorphism and severity of @entity402 in asthmatics.

@entity6306 @entity565 @entity4022 @entity402 @entity19825 @entity2939 @entity2710 @entity2574
Endotoxin exposure may have a protective effect against @entity565 and @entity402 . An @entity19825 polymorphism in the @entity2939 ( @entity2939 ) gene reduces responsiveness to endotoxin. This study determined the effect of @entity2939 polymorphism on the risk and severity of @entity565 and @entity402 . In all, 336 UK Caucasian families with > or = 2 affected sibs (physician's diagnosis of @entity565 and current medication use) and 179 Caucasians without @entity565 or a family history of @entity565 were genotyped using ARMS-PCR. No association of the @entity2939 polymorphism was found with the risk of developing @entity565 , either in parent-affected sibling trios, or in case-control analyses (P>0.05). In the first affected asthmatic siblings, the @entity402 score (based on size and number of positive skin-prick tests and specific IgE) was higher in those with the @entity2574 /Gly or @entity4022 /Gly genotypes (mean 1.8, s.d. 1.1, n=39) compared to those with the @entity2574 / @entity2574 genotype (mean 1.2, s.d. 1.0, n=279) (P=0.003, t-test). No associations were found with total IgE, FEV(1) % predicted, slope of FEV(1) response to @entity2710 or @entity565 severity score (P>0.05). This study confirms the previously observed lack of association of @entity2939 polymorphisms with @entity565 . In contrast, the findings suggest that genetically determined @entity6306 to endotoxin may increase @entity402 .
