Mortality and XXXX morbidity in a cohort of Canadian petroleum workers.

@entity3958 @entity5 @entity2 @entity7294 @entity2615 @entity1086 @entity15494
AIMS: To assess mortality and @entity5 morbidity in Canadian petroleum workers and explore exposure-response relations for specific petroleum agents. METHODS: A total of 25 292 employees hired between 1964 and 1994 were linked to the Canadian @entity5 registry and national mortality database. Exposure-response trends were assessed for @entity7294 solvents/fuels, @entity7294 lubricants, petroleum coke/spent catalyst, and @entity15494 ( @entity3958 ). RESULTS: External comparison analyses (mortality and incidence) showed deficits for all causes and all @entity5 combined and were consistent with expectation for most malignant and non-malignant sites analysed. @entity1086 mortality was increased among males based on four deaths, but cases had no common job assignments and the increase was focused in workers employed <10 years. Mesothelioma incidence was increased. Most exposure-specific analyses were compromised by small numbers. Statistically significant increases were observed for @entity3958 exposure and a subgroup of accidental deaths as well as for petroleum coke/spent catalyst exposure and @entity2 . While both findings have a degree of biologic plausibility, the @entity3958 association, which exhibited a clearer exposure-response pattern, could be subject to unmeasured confounders. Additionally, interpretation was complicated by the high correlation between @entity7294 and @entity3958 exposures. With @entity2 , the analysis could not adequately control for smoking, was based on small numbers, and exhibited a tenuous exposure-response pattern. CONCLUSION: The findings for @entity2615 suggest the need for continued attention to asbestos in the petroleum industry. The relation between accidental deaths and @entity3958 exposure deserves closer scrutiny in similarly exposed populations. Further analyses of @entity2 are underway and will be reported separately.
