@entity842 contributes to learning and @entity2414 observed in XXXX @entity35 during neonatal and juvenile growth.

@entity1375 @entity8326 @entity3937 @entity73 @entity1955 @entity842 @entity6836 @entity35 @entity2414 @entity1374
INTRODUCTION: Severe @entity73 follows @entity1374 during the neonatal period. The role of @entity842 (NO) in learning and memory has been widely investigated. METHODS: This study aimed to investigate the effect of @entity1375 during neonatal and juvenile periods on NO metabolites in the hippocampi of @entity35 and on learning and memory. Animals were divided into two groups and treated for 60 days from the first day of lactation. The control group received regular water, whereas animals in a separate group were given water supplemented with 0.03% @entity3937 to induce @entity1375 . Male offspring were selected and tested in the Morris water maze. Samples of blood were collected to measure the metabolites of NO, @entity6836 , @entity8326 and @entity1955 . The animals were then sacrificed, and their hippocampi were removed to measure the tissue concentrations of @entity6836 and @entity8326 . DISCUSSION: Compared to the control group's offspring, serum @entity1955 levels in the @entity3937 group's offspring were significantly lower (P<0.01). In addition, the swim distance and time latency were significantly higher in the @entity3937 group (P<0.001), and the time spent by this group in the target quadrant (Q1) during the probe trial was significantly lower (P<0.001). There was no significant difference in the plasma levels of NO metabolites between the two groups; however, significantly higher NO metabolite levels in the hippocampi of the @entity3937 group were observed compared to controls (P<0.05). CONCLUSION: These results suggest that the increased NO level in the hippocampus may play a role in the learning and @entity2414 observed in childhood @entity1375 ; however, the precise underlying mechanism(s) remains to be elucidated.
