[The change of adrenergic receptor-adenyl cyclase system on myocardial ischemic preconditioning in XXXX ].

@entity268 @entity573 @entity39 @entity1563 @entity1188 @entity35
AIM: To study the varies and effects of ischemic preconditioning of myocardium on every part of adrenergic receptor-adenyl cyclase system in @entity35 in vivo. METHODS: SD @entity35 were randomly divided into three groups: CON group (n = 6), IP group (n = 12) and I/R group (n = 12). Surgical procedure included intermittent @entity1563 and reperfusion. After the procedure, the hearts were extracted. We analyzed the @entity1188 size by TTC staining, measured serum myocardial enzymes, studied the beta-AR Bmax and @entity573 by radioligand binding assay of receptors (RAB), and checked the activity of AC and the content of @entity268 by radioimmunoassay (RIA). RESULTS: @entity1188 area were much smaller in IP group than in I/R group (P < 0.05). CK, CK-MB, LDH were significantly higher in I/R group (P < 0.01). The Bmax of beta-AR in IP group were much higher than in I/R group (P < 0.01). No difference of @entity573 could be seen between IP and I/R group. In IP group, the activity of AC and the content of @entity268 were higher than I/R group (P < 0.05). CONCLUSION: Ischemic preconditioning can protect the heart from @entity39 and reduce endo-enzyme leakage. Ischemic preconditioning can increase the density of beta-AR, the activity of AC and the content of @entity268 , which shows that the system of adrenergic receptor-adenyl cyclase system probably takes part in the protection of IP.
