[A study on the association between the use of oral contraception and XXXX : preliminary findings of a French study].

@entity1 @entity2208 @entity172 @entity0 @entity5 @entity42 @entity3942 @entity3799 @entity81 @entity1558
A case-control study of the relationship between oral contraceptive (OC) use and @entity0 in @entity1 aged 45 and under is currently underway in 4 @entity5 centers, a public assistance hospital, and 3 private clinics in France. The preliminary analysis is presented of 240 cases of @entity0 , 68 controls with @entity5 , and 246 controls with nonmalignant conditions except @entity1558 and moderate or @entity3799 . 46% of controls had benign and 7% had malignant thyroid conditions, 4% had @entity42 , 3% had uterine @entity81 , 6% had other gynecological conditions, 9% had other types of conditions, and 10% were hospital personnel, visitors, or @entity1 having routine examinations. The mean duration of OC use was not significantly different among different groups of controls. 3 factors were found to raise the risk of @entity0 significantly in the study population: a family history of @entity0 raised relative risk to 1.75, having 3 or fewer @entity1 raised it to 2.16, and having 2 or more induced abortions raised it to 1.75. Occupational status, marital status, age at menarche, age at 1st birth, number of @entity2208 , and @entity1558 were not associated with @entity0 . There was no association between @entity0 and duration of OC use or OC use before or after the 1st pregnancy or age 25. @entity1 beginning OC use before age 25 had a relative risk of .55 compared to other @entity1 . No increased risk of @entity0 was seen when various types of OCs, including combined, biphasic, sequential, or low or higher dosed @entity3942 only formulations were analyzed separetely, and users of progestagen only pills had a decreased incidence. There was no relationship between risk of @entity5 and @entity172 dose of combined, sequential, or biphasic pills. 4 factors were related to @entity5 : high occupational status, number of @entity1 , number of induced abortions, and history of @entity1558 . OC use was not significantly related to @entity5 . The relative risk of @entity5 was less than unity through 5 years of use and increased to 1.39 after 9 years, but still failed to attain statistical significance. The risk of @entity5 was found to increase with use of OCs for more than 7 years beginning after age 25. The sample size was too small to permit separate analysis for different types of OCs.
