Preadministration of @entity8726 suppresses prostaglandin production and XXXX in orthopedic @entity1 undergoing tourniquet inflation.

@entity1 @entity63 @entity1421 @entity4783 @entity158 @entity282 @entity8726
STUDY OBJECTIVES: To evaluate the effect of preadministration of @entity8726 on the plasma concentrations of @entity1421 ( @entity1421 ) and @entity282 . DESIGN: Prospective, randomized, controlled and double-blind study. SETTING: Inpatient surgery at Nagasaki Rosai Hospital. @entity1 : 32 ASA physical status I to II @entity1 scheduled for total knee arthroplasty or open anterior cruciate ligament reconstruction. INTERVENTIONS: @entity1 were randomly assigned to two groups. Five minutes before tourniquet inflation (350 mmHg), group A (n = 16) received placebo (intralipid, one mL . kg(-1)), and group B (n = 16) received @entity8726 one mg . kg(-1) IV. Catheters were placed in the ipsilateral femoral vein for collection of local blood and in a cubital vein for sampling of systemic blood. MEASUREMENTS: @entity1421 (femoral vein and cubital vein) was measured before tourniquet inflation (T1), before tourniquet deflation (T2), and immediately after tourniquet deflation (T3). Postoperative analgesia was provided with intravenous @entity4783 , 0.1 mg, on @entity1 demand. @entity158 (Visual Analog Scale) was assessed at 0.5, one, two, 4, 6, 12 and 24 hours after surgery. MAIN RESULTS: Visual Analog Scale and @entity4783 consumptions in group B were significantly lower than those in group A during the first 4 postoperative hours. In group A, @entity1421 in femoral vein increased significantly at T2 (359 +/- 105 pg mL(-1), P < 0.0001), compared with T1 (211 +/- 61 pg mL(-1)) and returned to control values at T3 (252 +/- 77 pg mL(-1)), whereas @entity1421 in the cubital vein showed no change. In group B, @entity1421 in either the femoral vein or cubital vein showed no change throughout the time course. CONCLUSIONS: Preadministration of @entity8726 suppresses the local production of @entity1421 during tourniquet @entity63 , resulting in reduced early @entity282 in @entity1 undergoing knee surgery.
