Cognitive and @entity146 among @entity15 XXXX from Latin America: Results of the RELACCEM study.

@entity1 @entity308 @entity146 @entity73 @entity16 @entity717 @entity15
BACKGROUND: @entity73 and @entity146 symptoms impact many aspects of the lives of @entity1 with @entity15 [ @entity15 ]. This literature is based largely on North American and Western European samples, and little is known about these aspects of @entity717 in Latin America. OBJECTIVE: RELACCEM is a longitudinal, multicenter study including @entity15 centers in Argentina, Chile, Columbia, Venezuela, Uruguay and Mexico. The goal is to determine the prevalence of @entity73 (two or more cognitive domains under the 5th percentile of healthy controls performance) and the full range of @entity146 in these regions, and how these symptoms relate to caregiver burden and employment. METHODS: @entity1 were 110 @entity1 with relapsing-remitting [RR] course and less than five years of disease duration. Thirty-four healthy controls were also recruited. All @entity1 were evaluated in one of 14 specialized centers. RESULTS: In additional to overall @entity16 , both cognition and @entity146 distinguished @entity1 and controls. The prevalence of @entity73 was 34.5% and 20.9% presented with clinically significant neuropsychiatric symptomatology. @entity73 was a significant predictor of employment status. CONCLUSIONS: This is the first multicenter epidemiological study of @entity15 -associated cognitive and @entity146 in Latin America. Results indicate that @entity73 and @entity308 and caregiver burden are already apparent at an early stage of the disease. The presence of @entity146 indicates the need for appropriate interventions as early as possible to mitigate psychosocial consequences of caregiver burden.
