Orthotopic transplantation during early infancy as therapy for incurable XXXX .

@entity1 @entity8 @entity500 @entity55 @entity205 @entity281 @entity299 @entity230 @entity204
Since November 1985, 14 neonates and young @entity1 have undergone orthotopic heart transplantation at Loma Linda University Medical Center (LLUMC) as therapy for hypoplastic aortic tract complex. Eleven (78%) survived surgery and are living and well today. Three perioperative @entity204 resulted: one due to perforated peptic ulcer, one due to necrotizing @entity55 , and one due to graft failure unrelated to rejection. No late @entity204 occurred in the 1-29 months of follow-up, during which time noninvasive surveillance techniques were used. Immunosuppression was accomplished using @entity205 and @entity500 . @entity230 and antithymocyte globulin were used for identified rejection episodes only. @entity281 were tolerated well. All survivors were normotensive. There was no late @entity8 . Although inadequate donor resources remain a significant limiting factor for transplantation therapy during early life, these results suggest that cardiac transplantation is effective therapy for selected neonates and young @entity1 with incurable @entity299 .
