Loop electrosurgical excision procedure and risk of XXXX during pregnancy: an observational study.

@entity1 @entity600 @entity281 @entity6124 @entity1047
OBJECTIVE: To investigate the risk for @entity600 associated with @entity281 in pregnancies after a @entity6124 ( @entity6124 ), compared with @entity1 with no prior @entity6124 . DESIGN: Multicentre retrospective cohort study. SETTING USA POPULATION: @entity1 with @entity6124 between 1996 and 2006 were compared with two unexposed groups who had cervical biopsy or Pap test, without any other cervical procedure, in the same calendar year. METHODS: The first pregnancy progressing beyond 20  weeks of gestation in @entity1 with prior @entity6124 was compared with pregnancy in @entity1 without @entity6124 . Stratified analysis according to the presence or the absence of @entity281 during pregnancy was used to investigate whether the risk for @entity600 differed according to the presence or the absence of @entity281 . The interaction between @entity6124 and @entity281 was investigated using multivariable logistic regression with interaction terms, as well as the Mantel-Haenszel test for homogeneity. MAIN OUTCOME MEASURES: Spontaneous @entity600 (<37 and <34  weeks of gestation). RESULTS: Of 1727 @entity1 who met the inclusion criteria, 34.4% (n  =  598) underwent @entity6124 prior to an index pregnancy. There was no increased risk for @entity281 among @entity1 with @entity6124 compared with @entity1 without @entity6124 . @entity1047 and @entity6124 demonstrated significant interaction, suggesting that the presence of @entity1047 in @entity1 with a history of @entity6124 augments the risk for @entity600 , compared with @entity1 with no history of @entity6124 . CONCLUSIONS: @entity281 during pregnancy in @entity1 with a history of @entity6124 may be associated with an increased risk for @entity600 , compared with @entity1 with no history of @entity6124 .
