Down-regulation of tissue microRNA-126 was associated with poor prognosis in @entity1 with XXXX .

@entity1 @entity320 @entity5 @entity10013 @entity6349
BACKGROUND: @entity10013 is frequently downregulated in a variety of @entity5 and acts as a potential @entity5 suppressor. It also played a @entity5 suppressor role in @entity1 @entity320 through the direct or indirect repression of several key oncogenic molecules. METHODS: qRT-PCR assay was performed to examine the expression of @entity10013 . Associations between @entity10013 expression and various clinicopathological characteristics were analyzed using the   (2) test. Survival rate was determined with Kaplan-Meier and statistically analyzed with the log-rank method between groups. Survival data were evaluated through multivariate Cox regression analysis. RESULTS: Significant differences for @entity10013 expression were shown between @entity6349 and primary @entity320 (P<0.01), between primary @entity320 and metastatic cutaneous @entity320 (P<0.01), and between primary cutaneous @entity320 and metastatic cutaneous @entity320 (P<0.001). The @entity1 with low @entity10013 expression showed shorter 5-year overall survival than those with high @entity10013 expression (P=0.039; log-rank test). Multivariate regression analysis showed that the status of @entity10013 expression was an independent prognostic factor overall survival (HR=3.782, 95% CI: 2.479-16.334, P=0.005). CONCLUSION: The status of @entity10013 might be an independent prognostic factor for @entity1 with @entity320 .
