@entity4381 results in better health-related quality of life following hip XXXX : the HORIZON-Recurrent @entity174 Trial.

@entity1 @entity4381 @entity173 @entity174
This study evaluated the benefits of ZOL versus placebo on health-related quality of life (HRQoL) among @entity1 from HORIZON-RFT. At month 24 and end of the study visit, ZOL significantly improved @entity1 ' overall health state compared to placebo as assessed by the EQ-5D VAS. INTRODUCTION: To evaluate the benefits of @entity4381 (ZOL) versus placebo on health-related quality of life (HRQoL) among @entity1 from The Health Outcomes and Reduced Incidence With @entity4381 Once Yearly Recurrent @entity174 Trial (HORIZON-RFT). METHODS: In this randomized, double-blind, placebo-controlled trial, 2,127 @entity1 were randomized to receive annual infusion of ZOL 5 mg (n = 1,065) or placebo (n = 1,062) within 90 days after surgical repair of @entity173 . HRQoL was measured using EQ-5D Visual Analogue Scale (VAS) and utility scores (EuroQol instrument) at months 6, 12, 24, 36, and end of the study visit. Analysis of covariance model included baseline EQ-5D value, region, and treatment as explanatory variables. RESULTS: At baseline, @entity1 (mean age 75 years; 24% @entity1 and 76% @entity1 ) were well matched between treatment groups with mean EQ-5D VAS of 65.82 in ZOL and 65.70 in placebo group. At the end of the study, mean change from baseline in EQ-5D VAS was greater for ZOL vs. placebo in all @entity1 (7.67    0.56 vs. 5.42    0.56), and in subgroups of @entity1 experiencing clinical @entity174 (8.86    4.91 vs. -1.69    3.42), @entity174 (5.03    2.48 vs. -1.07    2.16), and clinical @entity174 (5.19    2.25 vs. -0.72    1.82) with treatment difference significantly in favor of ZOL. EQ-5D utility scores were comparable for ZOL and placebo groups, but more @entity1 on placebo consistently had extreme difficulty in mobility (1.74% for ZOL vs. 2.13% for placebo; p = 0.6238), self-care (4.92% vs. 6.69%; p = 0.1013), and usual activities (10.28% vs. 12.91%; p = 0.0775). CONCLUSION: ZOL significantly improves HRQoL in @entity1 with @entity173 .
