Endocrine, cognitive and hippocampal/cortical 5HT 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in XXXX .

@entity73 @entity10463 @entity2730 @entity1005 @entity14919 @entity2819 @entity148 @entity701 @entity750 @entity35 @entity2414 @entity130
@entity1005 ( @entity1005 ) is characterised by hyperarousal, @entity148 and @entity2730 . Deficits in explicit memory recall have been causally related to volume reductions of the hippocampus and prefrontal cortex. While stress-related glucocorticoid secretion appears involved in this apparent atrophy, there is also evidence for low plasma @entity701 in @entity1005 . Prior exposure to @entity130 is an important risk factor for @entity1005 , suggesting a role for sensitisation. Using @entity35 , we studied the effects of a time-dependent sensitisation (TDS) model of stress on spatial @entity2414 , 1 week post-stress, using the Morris water maze. Basal and 7-day post-stress plasma @entity2819 levels were also determined. Due to the putative role of @entity750 in @entity148 and stress, and in the treatment of @entity1005 , hippocampal @entity10463 ) and prefrontal cortex @entity14919 ) radioligand binding studies were performed. TDS stress evoked a marked @entity2414 on day 7 post TDS stress, coupled with significantly depressed plasma @entity2819 levels. Cognitive and endocrine changes at day 7 post stress were associated with a significant increase in receptor density (B(max)) and a significant decrease in receptor affinity (K(d)) for hippocampal @entity10463 ) receptors. The B(max) of prefrontal cortex @entity14919 ) receptors were unaffected, but K(d) was significantly increased. We conclude that TDS stress evokes @entity73 . Moreover, TDS stress induces diverse adaptive 5HT receptor changes in critical brain areas involved in emotion and memory that may underlie the effect of stress on cognitive function.
