[Effect of @entity251 on the expression of CMTM family of the male spermatogenesis suppression XXXX ].

@entity3033 @entity251 @entity72957 @entity6319 @entity56045 @entity786 @entity72956 @entity72952 @entity72955 @entity72954 @entity35 @entity44770 @entity72953 @entity10145
This study is to investigate the influence and the expression of CMTM family of @entity251 on spermatogenesis suppression in the male @entity35 treated by @entity6319 and @entity786 . @entity6319 (50 mg kg(-1)) and @entity786 (20 mg kg(-1)) were administered to male @entity35 to induce spermatogenesis suppression. @entity3033 was administrated at the dose of 5 mg kg(-1) every other day for 6 times. Sperm was collected from the left @entity10145 , the count and motility of sperm were analyzed by @entity44770 . Morphological change of testis tissue was observed with HE staining. The expression of CMTM family was examined by Western blotting assay. @entity6319 (50 mg kg(-1)) and @entity786 (20 mg kg(-1)) decreased the count and motility of sperm, and the pathological change of testis tissue was also observed. But, @entity251 (5 mg kg(-1)) had positive effect. Furthermore, @entity72952 down-expressed remarkably in the @entity6319 and @entity786 treated @entity35 , the expression of the @entity72952 was up-expressed after @entity251 administration. On the contrary, the expression of CMTM2 increased significantly only in @entity6319 treated male @entity35 , but not in @entity786 treated male @entity35 . The expression of CMTM2 was down-expressed after @entity251 administration. However, no obvious change of CMTM2 was observed in @entity786 treated @entity35 . @entity251 did not influence the expression of @entity56045 , @entity72953 and @entity72954 , the @entity72955 , @entity72956 and @entity72957 of CMTM family were not detected in testis tissue. These demonstrated that the spermatogenesis effect of @entity251 (5 mg kg(-1)) was associated with the expression of CMTM family, and CMTM2 and @entity72952 may take part in the spermatogenesis process.
