Temporal evolution of regional energy metabolism following focal @entity2806 in the XXXX .

@entity1734 @entity308 @entity2806 @entity63 @entity2500 @entity209 @entity1188 @entity880 @entity35 @entity413 @entity855
Focal @entity2806 in the @entity35 was induced by occlusion of the left middle cerebral artery. The temporal evolution of regional energy metabolism was studied over the 14 days consequent to the induction of @entity63 in the frontal, cingulate, parietal, and occipital cortices as well as in the striatum. Regional concentrations of @entity855 ( @entity855 ), @entity1734 , and @entity880 and, in addition, @entity413 and the cerebral/plasma @entity413 ratio (C/P) were measured in the hemispheres both ipsilateral and contralateral to the occlusion. Two hours after @entity2500 , the biochemical changes were severe in the striatum and moderate in cortical regions. Later on (at 24 and 48 h), an overall aggravated metabolic status was noted while @entity880 declined and @entity413 markedly increased. These latter biochemical changes likely indicate a marked inhibition of the rate of @entity413 utilization. At 48 h, the energy reserves ( @entity855 , @entity1734 ) of parietal cortex no longer equaled those of other cortical regions, but abruptly fell to the levels found in the striatum without any increase in @entity880 level. Finally, at 7 and 14 days, the levels of the various metabolites in most cortical regions returned toward control values, although signs of a @entity308 @entity413 metabolism remained. However, in both striatum and parietal cortex, @entity855 and @entity1734 concentrations, although higher than those observed at 48 h, remained significantly decreased. Our present biochemical study permits the classification of these selected brain regions into three categories. First there are those that are outside the area of @entity1188 : the frontal, cingulate, and occipital cortices. These regions show little temporal evolution of brain energy metabolism but, notwithstanding, they are regions in which @entity413 use would appear to be greatly @entity308 . Second is a region considered to be the focus of @entity1188 : the striatum. The caudate-putamen is a region with early and profound @entity209 with no final restitution. Last is the region of metabolic penumbra--the parietal cortex, in which there is a time-related exacerbation of the consequences of middle @entity2500 in the @entity35 .
