Tea drinking as a risk factor for XXXX in northern China.

@entity1501 @entity73061 @entity1 @entity3570 @entity73060 @entity3976 @entity10413 @entity600 @entity601 @entity9796
BACKGROUND: Tea catechins inhibit the activity of the enzyme @entity9796 reductase, which catalyzes the inactive form of @entity1501 @entity73060 to the active form of @entity1501 @entity73061 . This inhibition leads to disturbance of the @entity1501 metabolic pathway and to lower bioavailability of @entity1501 to cells; therefore, it may increase the risk of @entity601 ( @entity601 ) in a developing embryo. We examined the association between tea drinking during the periconceptional period and the risk of @entity601 . METHODS: Cases were fetuses or neonates with an NTD as ascertained through a population-based surveillance system in 4 rural counties of Shanxi Province in northern China during 2002 through 2007. Controls were term @entity1 without @entity600 . Demographic, reproductive, and exposure data were obtained through a face-to-face interview. RESULTS: A total of 631 NTD cases and 857 controls were included in the analysis. Compared with @entity1 who did not drink tea during the periconceptional period (487 cases and 688 controls), @entity1 who drank tea daily (20 cases and 9 controls) had a 3-fold increased risk (odds ratio = 3.1 [95% confidence interval = 1.4-7.0]) of having an NTD-affected pregnancy. The elevated risk associated with daily tea drinking remained after adjusting for maternal age, educational level, occupation, and periconceptional @entity1501 supplementation (3.4 [1.4-8.3]). The association was present for all 3 major subtypes of @entity601 (ie, @entity10413 , @entity3570 , and @entity3976 ). CONCLUSIONS: Daily tea drinking during the periconceptional period was associated with an elevated risk of @entity601 in this Chinese population.
