Comparative study of @entity2756 monotherapy versus a combination regimen of XXXX plus @entity801 for treatment of serious @entity2348 : the efficacy, safety and effect on fecal flora.

@entity1 @entity801 @entity2756 @entity2261 @entity2348 @entity375 @entity204 @entity526
To assess the efficacy of once daily monotherapy relative to standard combination antibiotic therapy for the initial management of @entity1 suspected of serious @entity2348 , we conducted a randomized trial comparing @entity2756 ( @entity2756 ) with a combination of @entity2261 plus @entity801 . Of 105 @entity1 , 53 were treated with @entity2756 alone and 52 with the combination; 13 @entity1 were considered not evaluable. 42 of 53 @entity1 given @entity2756 and 33 of 52 given @entity2261 plus @entity801 responded to treatment (p = 0.07). Three @entity1 given @entity2756 and 6 who received @entity801 plus @entity2261 died (p = 0.28). Definite @entity2348 were identified in 67 @entity1 ; of the evaluable @entity1 with a definite infection 27 of 29 who received @entity2756 and 21 of 31 who were treated with the combination were cured (p = 0.01). No difference was found in the number of side effects. However, therapy had to be discontinued due to treatment failure, an adverse effect or @entity204 in 1 of 33 @entity1 given @entity2756 and in 11 of 34 given the combination (p = 0.002). @entity2756 was found to have an impact on the count of @entity526 in intestinal microflora. Changes in normal bacterial composition did not lead to the overgrowth with resistant Enterobacteriaceae or Pseudomonas, however, colonization by @entity375 was observed. Using @entity2756 reduced the cost of antimicrobial therapy per @entity1 by 107 pounds (US  183). Moreover, the total time save per @entity1 due to decreased nursing and drug administration time per day was 40 min.(ABSTRACT TRUNCATED AT 250 WORDS)
