Effect of XXXX on bone metabolism in @entity1 with @entity6 _ occurrence of @entity170 .

@entity1 @entity1697 @entity6 @entity170 @entity79 @entity12721 @entity2331
BACKGROUND _ OBJECTIVES: @entity6 ( @entity6 ) is considered to be a protective factor against development of @entity170 . But @entity1697 ( @entity1697 ) are likely to increase the risk of @entity170 . This study was carried out to evaluate the effect of various @entity1697 on @entity79 ( @entity79 ) in @entity1 with @entity6 . METHODS: Forty one @entity1 (study group) with @entity6 (mean age 51.9  5.5 yr; 31 females) receiving treatment with @entity1697 ( @entity1697 ) [ @entity12721 alone (n=14) or in combination with other @entity1697 (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51.4  5.1 yr) were included in the study. A detailed clinical history was taken and all were subjected to physical examination and recording of anthropometric data. @entity79 was assessed for both @entity1 and controls. RESULTS: The mean body mass index (kg/m [2] ) (26.5  4.90 vs 27.3   5.33) and median [inter-quartile range (IQR)] duration of menopause (yr) among @entity1 [6(2-12) vs 6(1-13)] were comparable between both groups. The @entity79 ( @entity79 ; g/cm [2] ) at the level of neck of femur (NOF) (0.761  0.112 vs 0.762  0.110), lumbar spine antero-posterior view (LSAP) (0.849  0.127 vs 0.854  0.135); median Z-score NOF {0.100[(-0.850)-(0.550)] vs -0.200[(-0.800)-(0.600)]}, LSAP {-1.200[(-1.700)-(-0.200)] vs -1.300 [(-1.85)-(-0.400)]} were also similar in study and control groups. Presence of normal @entity79 (9/41 vs 8/41), @entity2331 (16/41 vs 18/41) and @entity170 (16/41 vs 15/41) were comparable between the study and control groups. No significant difference was observed in the @entity79 , T-scores and Z-scores at NOF and LSAP among @entity6 @entity1 treated with @entity12721 ; those treated with other @entity1697 and controls. INTERPRETATION _ CONCLUSIONS: The present findings show that the use of @entity1697 for a period of three years or more does not significantly affect the @entity79 in @entity1 with @entity6 .
