The role of submucosal @entity4 in increased peripheral airway resistance by intravenous volume loading in XXXX .

@entity455 @entity235 @entity4 @entity891 @entity2647
@entity891 leads to an increase in airway resistance. It is still unknown whether this is due to @entity455 or to submucosal @entity4 . The present study was designed to determine the relative contribution of these two potential mechanisms. We examined the effect of intravenous volume loading on @entity235 peripheral airway resistance (Rp). Bronchoscopes were wedged in contralateral sublobar segments and used to record Rp during rapid infusion of normal saline. Volume loading with normal saline increased pulmonary capillary wedge pressure (PCWP) and Rp. Unlike normal saline, dextran 70 did not increase Rp when infused at a rate that produced similar changes in PCWP. During infusion of normal saline, delta Rp was significantly enhanced in lung segments previously challenged with dry air when compared to contralateral control lungs, unexposed to dry air, and the use of dextran 70 significantly reduced this effect. Vasoconstriction with @entity2647 significantly decreased baseline Rp, but did not completely reverse the effect of fluid infusion. In addition, in lung segments exposed to dry air, delta Rp was significantly greater after volume loading and treatment with @entity2647 when compared to contralateral control lung. Finally, muscarinic receptor blockade was ineffective in preventing Rp from increasing during infusion of normal saline. Our results suggest that volume loading-induced increases in Rp are not caused by either @entity455 or the stimulation of muscarinic receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
