Functional recovery in spinal cord injured XXXX using @entity25213 / @entity1496 implants and treadmill training.

@entity1688 @entity1496 @entity35 @entity25213 @entity25214 @entity1566 @entity451
Currently, there is no universally accepted treatment for @entity1566 ( @entity1566 ), a pathology that can cause @entity451 or @entity1688 . Due to the complexity of @entity1566 , more than one therapeutic strategy may be necessary to regain lost functions. Therefore, the present study proposes the use of implants of mesoparticles (MPs) of @entity25213 / @entity1496 (PPy/I) synthesized by plasma for neuroprotection promotion and functional recovery in combination with treadmill training (TT) for neuroplasticity promotion and maintenance of muscle tone. PPy/I films were synthesized by plasma and pulverized to obtain MPs. @entity35 with a @entity1566 produced by the NYU impactor were divided into four groups: Vehicle (saline solution); MPs ( @entity25214 /I implant); Vehicle-TT (saline solution  +  TT); and MPs-TT (PPy/I implant  +  TT). The vehicle or MPs (30   L) were injected into the lesion site 48  h after a @entity1566 . Four days later, TT was carried out 5  days a week for 2  months. Functional recovery was evaluated weekly using the BBB motor scale for 9  weeks and tissue protection using histological and morphometric analysis thereafter. Although the MPs of PPy/I increased nerve tissue preservation (P  =  0.03) and promoted functional recovery (P  =  0.015), combination with TT did not produce better neuroprotection, but significantly improved functional results (P  =  0.000) when comparing with the vehicle group. So, use these therapeutic strategies by separately could stimulate specific mechanisms of neuroprotection and neuroregeneration, but when using together they could mainly potentiate different mechanisms of neuronal plasticity in the preserved spinal cord tissue after a @entity1566 and produce a significant functional recovery. The implant of mesoparticles of @entity25213 / @entity1496 into the injured spinal cord displayed good integration into the nervous tissue without a response of rejection, as well as an increased in the amount of preserved tissue and a better functional recovery than the group without transplant after a @entity1566 by contusion in @entity35 . The relevance of the present results is that @entity25213 / @entity1496 implants were synthesized by plasma instead by conventional chemical or electrochemical methods. Synthesis by plasma modifies physicochemical properties of @entity25213 / @entity1496 implants, which can be responsible of the histological response and functional results. Furthermore, no additional molecules or trophic factors or cells were added to the implant for obtain such results. Even more, when the implant was used together with physical rehabilitation, better functional recovery was obtained than that observed when these strategies were used by separately.
