Regular exercise (3x45 min/wk) decreases plasma viscosity in sedentary XXXX , insulin resistant @entity1 parallel to an improvement in fitness and a shift in substrate oxidation balance.

@entity1 @entity2003 @entity28 @entity209 @entity1720 @entity258 @entity3363 @entity2231
Exercise training decreases blood viscosity in athletes parallel with metabolic improvements mostly characterized by an @entity1720 . @entity1 with @entity258 exhibit a host of @entity209 that may also benefit from regular training. However, the hemorheologic aspects of training in such subjects are not known and we aimed at characterizing them. SUBJECTS: Thirty-two @entity28 insulin resistant subjects were tested before and after 2 months. Twenty-one of them were trained (3x45 min/wk) at a level defined by exercise calorimetry and corresponding to the power at which lipid oxidation reaches a maximum (LIPOX(max )) and eleven served as controls. The two groups were matched for age and body mass index. There was no weight change in controls while the 2 months training period decreased weight by 2.5 kg (p<0.02). This change was totally explained by a loss in fat mass (-2.7 kg, p<0.02) while fat free mass remained unchanged. Blood rheology was unchanged in the control group while training improved plasma viscosity @entity2231 (pl) (before: 1.43+/-0.03 mPa.s; after: 1.35+/-0.03 mPa.s, p<0.02). There was no change in either hematocrit, @entity2003 or red cell aggregation. The balance of substrates oxidation shifted towards a higher use of lipids (point of crossover where subjects oxidize 70% @entity3363 30% lipids: before 39.3+/-6.9 watts; after 70.8+/-6 watts, p<0.001; point where lipid oxidation is maximal (LIPOX(max )) before: 16.5+/-1.4 watts; after: 21.4+/-1.3 watts, p<0.001) and V(O(2max )) increased by 74% (p<0.01). Consistent with observations in athletes, the metabolic and ergometric improvements induced by training reduces @entity2231 (pl) in sedentary, insulin resistant @entity1 , but at those low levels training does not appear to induce "autohemodilution" (as reflected by hematocrit) neither it improves red cell deformability or aggregation. The reliability of @entity2231 (pl) as simple and unexpensive marker of efficiency of training in insulin resistant @entity1 should be further evaluated.
