The association between XXXX in maternal circulation and pathological intrauterine fetal growth restriction.

@entity1 @entity40590 @entity1503
OBJECTIVE: To assess the diagnostic accuracy of maternal serum @entity40590 ( @entity40590 ) in identifying pathological intrauterine fetal growth restriction (IUFGR) among @entity1 presented in the third trimester of pregnancy with a small for gestational age (SGA) fetus. STUDY DESIGN: This case control study was conducted in Ain-Shams University Maternity Hospital, Abbasiya Square, Cairo, Egypt and included @entity1 diagnosed at the third trimester of pregnancy as having a SGA fetus. Cases included pregnant @entity1 with pathological IUFGR, while @entity1 with physiologically SGA fetus were included in the control group. Diagnosis of antenatal SGA fetus was based on the presence of abdominal circumference <10th percentile. Pathological IUFGR was provisionally diagnosed antenatally by the presence of falling percentiles on serial ultrasound scans and then the definitive diagnosis was established postnatally after comprehensive neonatal evaluation. @entity1503 were collected from the eligible @entity1 , once at the time of enrollment, to assess serum @entity40590 levels using enzyme-linked immunosorbent assay (ELISA). Both groups were then followed up till delivery to confirm the diagnosis. RESULTS: Among the 68 pregnant included in the study, @entity40590 was found to be significantly elevated in @entity1 with SGA fetus due to pathological IUFGR (n=34) than those with physiologically SGA fetus (n=34) [6.5ng/ml (2.5-11.0) versus 1.2ng/ml (0.8-2.5) respectively], with a best cutoff value of >= 1.3ng/ml [sensitivity of 85.3% (95% confidence interval (CI), 68.9-95.0) and a specificity of 73.5% (95% CI, 55.6-87.1)]. Using multivariable binary logistic regression model, amniotic fluid index (AFI) (P=0.010), estimated fetal weight (EFW) (P=0.016), @entity40590 level (P=0.041), and umbilical artery pulsatility index (UA-PI) (P=0.027) were all found to be independent diagnostic markers for pathological IUFGR. CONCLUSION: @entity40590 is a promising marker that deserves further evaluation as it may differentiate normal and abnormal fetal growth among @entity1 presenting at third trimester of pregnancy with a SGA fetus.
