Coexistence of @entity444 and XXXX with two mosaic cell lines 45,X/46,X,del(X)(p22.2).

@entity1 @entity14258 @entity172 @entity170 @entity53 @entity444 @entity2588 @entity65
@entity444 and @entity14258 both are common causes of primary @entity2588 . Coexistence of @entity444 and @entity14258 has been previously described as a rare event. The karyotypes, 45,XO,45,X/46,XX,45,X/46,X,dic(X),46,XX, and 46,XY, have been reported in the literature. A 22-year-old @entity1 presented with primary @entity2588 and normal intelligence. Her physical examination confirmed the absence of breast development and axillary hair. The @entity1 weighed 43 kg and was 150 cm tall. Scoliosis of the thoracic spine was noted on a chest X-ray film. Also, her pelvic examination revealed a vaginal introitus with a vaginal depth of 7 cm, measured by sounding. Her external genitalia were female but lacked pubic hair. The rectal examination failed to reveal a uterus. Pelvic ultrasound disclosed the absence of uterus and ovaries, and her serum gonadotropin levels were in the menopausal range (FSH, 118.59 IU/L; LH, 38.94 IU/L). @entity53 was less than 10 pg/ml. Two mosaic cell lines, 45,X (50%) and 46,X,del(X)(p22.2X50%), were found in the chromosomal study. Laparoscopic evaluation confirmed the absence of uterus and ovaries with normal fallopian tubes. Coexistence of @entity444 and @entity14258 is a rare event. The two mosaic cell lines 45,X/46,X,del(X)(p22.2) in this combination have not been reported before. In @entity1 with this condition, @entity172 will initiate and sustain maturation and function of secondary sexual characteristics, and lifelong hormone therapy will protect against @entity170 and @entity65 .
