Efficacy of XXXX in hearing preservation after radiosurgery for @entity5513 : a prospective study.

@entity1 @entity5513 @entity5 @entity228 @entity393 @entity288
OBJECTIVES: We prospectively investigated the efficacy of corticosteroid medication in salvaging acute @entity393 after radiosurgery for @entity5513 ( @entity5513 ) and analyzed prognostic factors for hearing preservation. METHODS: Forty-one @entity1 with serviceable hearing treated with gamma knife radiosurgery between 2004 and 2006 were included. Nineteen @entity1 who suffered acute @entity393 after radiosurgery were treated with oral @entity288 . The efficacy of @entity288 was compared with the results of a historical observation group of 15 @entity1 who had experienced @entity393 but who had not taken @entity288 . RESULTS: The @entity5 control rate and serviceable hearing preservation rate at the last follow-up were 97.6 and 61%, respectively. There was no significant difference in the actuarial serviceable hearing preservation rates between the @entity228 treatment group and the historical observation group (p = 0.519). However, the mean pure-tone averages were significantly different between the 2 groups (51.5 vs. 63.7 dB; p = 0.025). Multivariate analysis revealed that preradiosurgery hearing status and transient volume expansion were prognostic factors for hearing preservation (p = 0.013 and p = 0.029, respectively). CONCLUSIONS: This study demonstrates the possibility that corticosteroid medication may improve acute @entity393 after radiosurgery in @entity5513 @entity1 . Further studies on optimal corticosteroid medication for managing acute @entity393 after radiosurgery are mandatory.
