Feasibility of concurrent XXXX and extended field radiation therapy (EFRT) using intensity-modulated radiotherapy (IMRT) for carcinoma of the cervix.

@entity1 @entity137 @entity5 @entity900 @entity1398 @entity8376 @entity236
OBJECTIVES: To assess the acute tolerance of delivering concurrent @entity900 and extended field radiotherapy (EFRT) using intensity-modulated radiotherapy technique (IMRT) for @entity5 . METHODS: All @entity1 receiving definitive treatment for cervical @entity5 were treated with EFRT using IMRT technique and concurrent @entity900 . The treatment volume included the cervix, uterus, parametria, presacral space, @entity8376 , pelvic, common iliac, and paraaortic nodes to the top of L1. All regions received 45 Gy (25 fractions) with a simultaneous boost to involved nodes (55 Gy/25 fractions). @entity1 were assessed weekly for @entity137 and response. RESULTS: Twenty-two consecutive @entity1 underwent treatment. All @entity1 completed the prescribed course of EFRT. Median treatment length was 39.5 days (range 36-53). Treatment breaks of 2 and 3 days were required for bone @entity236 in 2 @entity1 . The final week of chemotherapy was held in 2 @entity1 because of @entity1398 . No @entity1 suffered acute or subacute grade 3 or 4 GI or GU @entity137 . CONCLUSION: In this clinical study, an IMRT technique was used to successfully deliver EFRT with concurrent chemosensitization for cervical @entity5 . The technique was associated with an acceptable acute @entity137 without significant treatment protraction. This new role for IMRT merits further evaluation with larger @entity1 numbers and longer follow-up.
