Pregnancy outcome of intensive therapy in severe XXXX in first trimester.

@entity1 @entity1143 @entity101 @entity75 @entity177 @entity1468 @entity204
The purpose of the present clinical investigation was to determine the maternal and perinatal outcome associated with continuing pregnancy in 44 consecutive @entity1 with severe chronic @entity101 in the first trimester. Each @entity1 was observed closely throughout pregnancy with frequent prenatal visits and intensive monitoring of the clinical status of both mother and fetus. There were no maternal deaths, but morbidity was very significant. Most @entity1 required repeated hospitalizations and on many occasions parenteral medications were used to reduce blood pressure. Nineteen had transient and one permanent @entity177 . These results confirm that pregnancy in @entity1 with severe @entity101 is beset with considerable morbidity, but with expert intensive care, gestations can be concluded successfully in those @entity1 who refuse termination. Twenty-three @entity1 (52%) developed superimposed @entity1468 , one @entity1 developed @entity1143 , and one @entity1 had postpartum hypertensive @entity75 . In addition, there was no evidence of late puerperal maternal cardiovascular or renal damage on long-term follow-up. There were ten stillbirths and one @entity204 for an overall perinatal mortality of 25%. Seventy percent of the @entity1 were delivered before 37 weeks' gestation, and 19 @entity1 (43%) were small for gestational age. However, all the perinatal deaths and most of the neonatal morbidity occurred among the 23 @entity1 with superimposed @entity1468 .
