Effects of treatment on the histopathology of XXXX .

@entity1 @entity5117 @entity738 @entity75 @entity406 @entity1202 @entity272 @entity1201
AIMS: To identify the histological changes in @entity272 over the first few weeks after the start of @entity1201 treatment and to examine their relationship to reversal reaction. METHODS: Sequential skin biopsy during treatment with multiple drug therapy. In this study, a series of 28 @entity1 was studied, from whom two or more biopsies were taken at two week intervals. Fourteen @entity1 had @entity5117 ( @entity5117 ) and 14 had @entity1202 ( @entity1202 ). RESULTS: In most cases, @entity738 fraction and bacterial index fell during treatment, the bacterial index being less sensitive than the @entity738 fraction. Since the biopsies were fixed in buffered @entity406 and processed through to paraffin wax, little immunohistochemistry was feasible. However, there was strong evidence of immune activation, with increased expression of HLA-DR in the @entity738 of @entity1202 and @entity5117 cases: the epidermis also expressed HLA-DR in several @entity1 . Such changes may reflect gamma IFN production from @entity738 lymphocytes. @entity1 with reversal reaction often showed HLA-DR expression on admission which decreased with corticosteroid treatment. CONCLUSIONS: The results suggest that activation of cell mediated immunity in @entity75 occurs during treatment with multiple drug therapy and may not be restricted to those with clinical evidence of reversal reaction.
