Observations and outcomes of urethroplasty for @entity850 after radiation therapy for XXXX .

@entity1 @entity323 @entity263 @entity322 @entity3832 @entity850
PURPOSE: @entity850 is a significant complication of radiotherapy for @entity263 . Our purpose is to report outcomes of urethroplasty for radiation-induced @entity3832 . METHODS: Thirty-five @entity1 underwent urethroplasty for refractory radiation-induced @entity850 from January 2004 to November 2013. @entity1 had a minimum follow-up of 12  months with routine cystoscopy at 6 and 12  months. Primary outcome was urethral patency, and secondary outcomes were 90-day complications, de novo @entity322 , de novo @entity323 and bothersome LUTS. Outcomes were compared using Fisher's exact test. RESULTS: Of the 35 @entity1 , 20 and 15 had @entity850 related to external beam radiation therapy and brachytherapy, respectively. Mean stricture length was 3.5  cm. Reconstruction was performed using anastomotic urethroplasty in 23 @entity1 (65.7  %), while 12 required tissue transfer as a buccal mucosa graft (20.0  %) or penile island flap (14.3  %). With 50.5  months of follow-up, thirty @entity1 (85.7  %) achieved cystoscopic patency with no significant difference between techniques (p  =  0.32). A 90-day complication rate of 31.4  % was observed (all Clavien 1-2) with no difference between techniques (p  =  1.00). Adverse change in continence occurred in 25.7  % of @entity1 (13.3  % in those without previous TURP). Postoperatively, persisting storage LUTS occurred in 40.0 and 30.4  % described adverse change in erectile function (exclusively in the anastomotic urethroplasty group). CONCLUSIONS: Reconstruction of radiation-induced @entity850 yields satisfying patency rates. However, radiation-induced @entity3832 is not an isolated problem as many @entity1 suffer from storage symptoms, @entity323 or @entity322 as a consequence of treatment either before or after urethroplasty.
