Statins are independently associated with increased HbA1c in @entity164 1 XXXX - The Thousand _ 1 Study.

@entity1 @entity8 @entity1289 @entity6 @entity989 @entity470 @entity1674 @entity117 @entity633 @entity164 @entity65 @entity299 @entity460 @entity6817 @entity165
AIMS: @entity6817 use has been associated with increased risk of developing @entity164 2 @entity6 (T2DM), and with impaired glycemic control in T2DM @entity1 . The association between @entity6817 use and glycemic control in @entity164 1 @entity6 (T1DM) is unknown. The association between use of statins and glycemic control in T1DM @entity1 without known @entity299 was examined. METHODS: Cross-sectional study of 1093 T1DM @entity1 from the outpatient clinic at Steno @entity6 Center. Physical examination, questionnaires, and echocardiography were performed in all @entity1 . Investigators were blinded to all laboratory measurements. Data were analyzed in uni-and multivariable models. RESULTS: Mean age 49.6 years, 53% @entity1 , mean @entity6 duration 25.5 years, 475 (43.5%) received @entity6817 . In baseline analyses @entity6817 users tended to be older, have longer @entity6 duration, and have more severe @entity8 . Left ventricular ejection fraction was not associated with @entity6817 use. In multivariable models including age, gender, @entity6 duration, BMI, blood pressure, physical activity, family history of @entity65 , physical activity, @entity633 , @entity470 , @entity989 , smoking, @entity165 , ejection fraction, @entity1674 , and use of @entity1289 /ATII-antagonists, @entity117 , @entity460 -antagonists, betablockers or diuretics, @entity6817 use was independently and significantly associated with higher HbA1c (0.2% (95%CI: 0.1; 0.4) (2.0mmol/mol (0.2; 3.8)), p=0.029). CONCLUSIONS: In T1DM, use of statins is independently associated with impaired glycemic control. A causal relationship cannot be determined from this study. Given the benefit on cardiovascular outcome, this should not cause @entity1 to stop @entity6817 treatment, but may indicate a need to revisit dose of insulin when starting @entity6817 treatment.
