Positron Emission Tomography for Nine XXXX (Bladder, Brain, Cervical, Kidney, Ovarian, Pancreatic, Prostate, Small Cell Lung, Testicular)

@entity1 @entity43 @entity788 @entity419 @entity4153 @entity5
OBJECTIVE: To review and synthesize the evidence on the use of @entity419 -PET in the assessment and treatment of nine types of @entity5 with respect to the following clinical situations: diagnosis, @entity5 , restaging, and monitoring response to treatment. DATA SOURCES: Comprehensive searches were conducted in four relevant electronic databases for the time period from 2003 to March 2008. REVIEW METHODS: Studies should be published in English, with more than 12 adult @entity1 with primary @entity5 of the following type: bladder, brain, cervical, kidney, ovarian, pancreatic, prostate, small cell lung, and testicular. Restrictions regarding study design were not imposed. Two independent reviewers assessed study relevance, extracted the data and assessed the methodological quality of the studies. A combination of qualitative and quantitative approaches was used to synthesize the data. RESULTS: One hundred and nine articles were included in this report. The strongest evidence for the diagnostic accuracy of @entity419 -PET or @entity419 -PET/CT has been produced for @entity5 of locally advanced cervical @entity5 and the detection and restaging of recurrent disease, the detection of @entity43 recurrences following treatment, and the diagnosing and initial @entity5 of @entity788 . These and other indications require further research to show the impact of @entity419 -PET or @entity419 -PET/CT on @entity1 management or added value in the diagnostic and therapeutic process. CONCLUSION: For some type of @entity5 (e.g., cervical, ovarian, and @entity788 ), there is some evidence of the utility of @entity419 -PET or @entity419 -PET/CT for diagnosing, @entity5 , or detecting recurrences, but they may still require more studies to augment the evidence base. Further studies are needed to reach firm conclusions about the clinical effectiveness of @entity419 -PET and @entity419 -PET/CT in terms of the impact on diagnosis and treatment options, @entity1 -centered outcomes, and economic costs. It is still unclear how @entity419 -PET and @entity419 -PET/CT affects @entity1 treatment and ultimately their outcome. For other types of @entity5 examined in the review (e.g., bladder, kidney, prostate, @entity4153 , and testicular) the answers are still inconclusive and require more careful study.
