Changes in lysosomal enzymes in acute experimental XXXX .

@entity7008 @entity4314 @entity39 @entity35 @entity1232 @entity99
1. An investigation has been made of the changes occurring in lysosomal enzyme activities during the early development of experimentally produced @entity99 in the @entity35 . Three enzymes have been studied: acid phosphatase, acid ribonuclease and beta-glucuronidase. Four different methods of inducing @entity99 have been used: administration of @entity4314 , @entity7008 , @entity1232 and the fungal toxin sporidesmin. 2. The majority of the data presented concern alterations produced by @entity4314 . Despite the extensive central @entity39 and accompanying fat accumulation which this poison produced in the liver, only small changes in the activity and latency of lysosomal enzymes could be detected. In the early (pre-necrotic) period of injury these changes were insignificant. At a late stage of injury, when @entity39 was present, there were indications of lysosomal rupture. 3. The results obtained with the other three hepatotoxins were similar to those described for @entity4314 in that no evidence of early lysosomal rupture was obtained during the pre-necrotic period. It is concluded that lysosomes probably play no role in the early development of the four types of @entity99 studied but, instead, are involved in later scavenging processes.
