[Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of XXXX and @entity1483 ].

@entity1 @entity101 @entity7690 @entity2514 @entity1483 @entity12921 @entity177
Increasing dosages of two potent diuretic agents (5, 10, 20 mg @entity12921 or 40, 80, 160 mg @entity1483 ) were compared in 35 @entity1 with @entity101 and @entity177 . In cases with insufficient blood pressure control, 10 mg @entity7690 was given as a second drug. Finally, @entity1 not responding to a betablocker-diuretic combination received 100 mg @entity2514 as a third drug. Both diuretics had comparable antihypertensive potency during a treatment period of up to 12 weeks. Maximal antihypertensive response was observed under 10 mg @entity12921 or 160 mg @entity1483 . However, only in 25% of our @entity1 blood pressure was normalized with diuretic monotherapy ( @entity12921 or @entity1483 ). The remaining cases needed either an additional betablocker or a combination of three different antihypertensive agents. Under these conditions a substantial proportion of our @entity1 (20%) did not reach the therapeutic goal (diastolic blood pressure less than 95 mm Hg). These results document the difficulties of @entity101 management in @entity177 . An early change to the stepped-care approach should be made in all cases with insufficient blood pressure response to potent diuretics.
