Therapeutic keratoplasty for advanced XXXX .

@entity1 @entity796 @entity1036 @entity8963 @entity281 @entity364
PURPOSE: To determine indications, therapeutic success, and corneal transplantation techniques for advanced medically uncontrolled @entity1036 . DESIGN: Retrospective, interventional case series. METHODS: A review of 92 consecutive @entity1 (1991 to 2002) who underwent therapeutic keratoplasty for @entity8963 performed at Singapore National Eye Centre. Causative organism(s) were identified and outcomes were evaluated in terms of infectious cure (therapeutic success), graft clarity, and visual acuity. RESULTS: @entity796 (58.7%) and Fusarium species (32.3%) were the predominant organisms for @entity364 , respectively. Keratoplasty types included penetrating keratoplasty (PK; n = 80) and lamellar keratoplasty (n = 12). Mean graft diameter was 9.5 mm (range, 5.5 to 14 mm). Seventy-four @entity1 (80.4%) achieved therapeutic success after one keratoplasty procedure, three @entity1 were cured after a second keratoplasty. Life-table survival analysis computed the one-year therapeutic survival for @entity364 as 76.6% and 72.4%, respectively (P = .76). The Kaplan-Meier one-year survival rate for PK optical clarity was 72%. Twenty-two @entity1 underwent repeat keratoplasty for various reasons (optical, n = 8; recurrent @entity281 , n = 7; perforation or subsequent new @entity281 , n = 7). Of the 15 @entity1 for whom therapy failed, 11 had @entity364 . Infection recurrence time was four days to one year. Most recurrences (n = 11) appeared within six weeks after surgery. CONCLUSIONS: Therapeutic keratoplasty may treat severe, refractory @entity1036 effectively. High cure rates are achievable, although infection recurrence despite prolonged treatment remains a significant problem in @entity364 .
