Subjective Responses to XXXX Are Influenced by @entity5834 Dose, Sex, and Pubertal Stage.

@entity1 @entity5834
UNASSIGNED: Background: Our previous work has shown that there are sex differences in subjective responses to acute @entity5834 administration in adolescents. The purpose of this study was to determine if these sex differences are dependent on pubertal development. Materials and Methods: We examined subjective responses before and after administration of 0, 1, and 2   mg/kg of @entity5834 in pre- and postpubertal @entity1 and @entity1 (n   =   112). In addition, we examined differences in subjective responses to acute @entity5834 in both the luteal and follicular phases of the menstrual cycle in postpubertal @entity1 . Results: @entity5834 at both doses resulted in greater changes in responses on the Addiction Research Center Inventory and the Brief Assessment of Mood States compared with placebo. @entity1 reported greater increases from baseline to peak in feeling different and liking the feeling than @entity1 after 2   mg/kg of @entity5834 regardless of pubertal stage. Postpubertal @entity1 also had a greater decrease from baseline in reports of feeling high and greater increases from baseline in reports of wanting more than postpubertal males. Finally, @entity1 had greater changes (both increases and decreases) in responses on the Brief Mood Questionnaire when in the follicular phase compared with the luteal phase. This was also true for reports of feeling high and feeling different on the Drug Effects Questionnaire. None of these effects varied as a function of usual @entity5834 use, suggesting that differences are not the result of tolerance or sensitization. Conclusions: These results suggest that subjective responses to @entity5834 emerge before puberty, but sex differences may be strengthened after pubertal development.
