Antifibrillatory properties of @entity6231 after coronary artery occlusion in XXXX .

@entity6231 @entity1165 @entity26 @entity2683 @entity2224 @entity35 @entity943 @entity204
Ligation of the left anterior descending coronary artery was performed in open-chest anaesthetized @entity35 and mortality as well as changes in ECG were evaluated for 30 min thereafter. Saline or drugs were administered 15 min prior to ligation. In the control group, following a 4 min lag period @entity943 as single ectopic beats, @entity1165 and @entity2224 ( @entity2224 ) appeared, reaching a maximum between 10 and 20 min and disappearing after 30 min. Mortality (40% in the control group) coincided with the period of maximal @entity943 , with @entity2224 more common in animals that died than in those surviving. @entity6231 , a drug which reduces sino-atrial rate specifically but has no conventional antiarrhythmic properties, reduced mortality and @entity2224 . By means of order statistics the quantity 'risk of @entity204 ' was used for evaluation of drug effects, considering incidence of @entity204 and @entity2224 as well as duration of @entity2224 . This quantity was reduced in correlation with the dose of @entity6231 (1-6 mg/kg i.v.) and in correlation with the reduction of heart rate. @entity2683 , an antiarrhythmic drug with membrane-depressant properties, also reduced the 'risk of @entity204 ' dose dependently (1-10 mg/kg i.v.), but there was no correlation with a decrease in heart rate. It is suggested that @entity6231 reduced 'risk of @entity204 ' by means of a reduced @entity26 demand due to a decrease in heart rate.
