Effects of XXXX on renal function following orthotopic heart transplantation.

@entity1 @entity1458 @entity177 @entity205 @entity1011
The early and late nephrotoxicity of @entity205 was examined in 23 orthotopic heart transplant recipients and two heart-lung transplant recipients up to four years after the operation. @entity205 was given orally pre-operatively and intravenously for the first two to five days after the operation. Subsequent daily oral therapy, in two divided doses, was adjusted to maintain serum trough levels in the range of 150 vg/ml to 200 vg/ml. By six months after the transplantation, the trough level was reduced to approximately 100 vg/ml. The mean pre-operative @entity1011 was 119 +/- 27 microM/L. After the operation there was transient @entity1458 in all @entity1 , the mean peak @entity1011 (251 +/- 104 microM/L) occurring on days two to five. By day eight, @entity1011 (138 +/- 68 microM/L) was not significantly different from the pre-operative value. The maximal @entity205 trough level (479 +/- 216 vg/ml) was also seen on days two to five and declined (195 +/- 53 vg/ml) on day ten. Despite the temporal association, linear regression analysis demonstrated no correlation between the early increase in @entity1011 and the @entity205 level. There was, however, a correlation between the pre-operative @entity1011 and the peak post-operative @entity1011 . Two @entity1 required dialysis but no death could be attributed to @entity177 . By six months after the operation, serum @entity1011 had increased to 145 +/- 53 microM/ml and thereafter, with gradual reduction in @entity205 dosage serum @entity1011 levels stabilized at 197 +/- 97 mu/mL at two years.(ABSTRACT TRUNCATED AT 250 WORDS)
