Association of adenovirus 36 infection with XXXX -related gene variants in adolescents.

@entity1 @entity18957 @entity9504 @entity20903 @entity72843 @entity28 @entity21944 @entity72842 @entity1628 @entity23158 @entity2252 @entity11620 @entity23157 @entity22320 @entity23156
Both, common gene variants and @entity1 adenovirus 36 (Adv36) are involved in the pathogenesis of @entity28 . The potential relationship between these two pathogenic factors has not yet been investigated. The aim of our study was to examine the association of @entity28 susceptibility loci with Adv36 status. Genotyping of ten gene variants (in/near @entity20903 , @entity21944 , @entity23157 , @entity11620 , @entity2252 , @entity23156 , @entity1628 , @entity18957 ) and analysis of Adv36 antibodies was performed in 1,027 Czech adolescents aged 13.0-17.9 years. Variants of two genes ( @entity11620 and @entity2252 ) were associated with Adv36 seropositivity. A higher prevalence of Adv36 antibody positivity was observed in @entity28 risk allele carriers of @entity11620 @entity72842 , @entity22320 and @entity2252 @entity72843 vs. non-carriers (chi(2)=6.59, p=0.010; chi(2)=7.56, p=0.023 and chi(2)=6.84, p=0.033, respectively). The increased risk of Adv36 positivity was also found in @entity11620 variants: @entity72842 (OR=1.67, 95 % CI 1.11-2.49, p=0.016) and @entity22320 (OR=1.34, 95 % CI 1.08-1.67, p=0.010). @entity11620 @entity72842 and @entity2252 @entity23158 variants were closely associated with Adv36 status in @entity1 and @entity1 , respectively (chi(2)=5.09, p=0.024; chi(2)=7.29, p=0.026). Furthermore, @entity11620 @entity22320 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/ @entity28 subgroup. In conclusion, our results suggest that @entity28 risk variants of @entity11620 and @entity2252 genes may be related to @entity9504 .
