The Impact of Systemic and Local Administration of @entity620 on Traumatic Perforation of Tympanic Membrane and XXXX .

@entity32 @entity620 @entity4 @entity1711 @entity14360 @entity1710 @entity35
OBJECTIVE: In the present study, tympanic membranes (TM) harvested from myringotomized @entity35 were analyzed histopathologically to compare the systemic and local effects of @entity620 on the development of @entity14360 . MATERIALS AND METHODS: Forty male @entity35 -Albino @entity35 weighing between 350-400 g were included in this study. Under otomicroscopic examination, a standard 2-mm myringotomy incision was made on the posteroinferior quadrant of the TM of both ears. @entity35 were randomized into five groups as control, topical @entity620 50 mg/kg, systemic @entity620 50, 100, and 200 mg/kg groups, each group containing eight @entity35 . On the 15th day of the study, the @entity35 were decapitated, and bullas of the @entity35 were extracted. Sections were stained with @entity1710 - @entity1711 and examined through light microscopy. @entity32 , distribution width of plaques, @entity4 , and neovascularization were observed on the lamina propria. Thickness of the TM was evaluated under the microscope and scored semiquantitatively. RESULTS: When intergroup comparisons of parameters related to total TM thickness were performed, differences between the control group and topical AA ( @entity620 ) or systemic treatment groups were found to be statistically significant (p<0.005). A statistically significant difference was detected among control, topical and systemic 200 mg/kg @entity620 groups for the @entity4 (p=0.003 and p<0.05, respectively). CONCLUSION: For the total TM thickness, systemic and topical @entity620 use was effective when compared with the control group. It has been concluded that systemic use of higher doses of (200 mg/kg) @entity620 is beneficial in the resolution of the @entity4 .
