Role of cross- XXXX to latex in clinical routine of anesthesia.

@entity1 @entity566 @entity2023 @entity2144
STUDY OBJECTIVE: To determine the applicability and reliability of a screening questionnaire to detect @entity1 at high-risk of @entity2144 ; to assess the importance of other @entity566 such as profilin @entity566 ( @entity2023 ) for presence of latex sensitization; and to determine the clinical effectiveness of preemptive avoidance of latex exposure in high-risk @entity1 . DESIGN: Prospective, clinical trial. SETTING: Operative theater of a university hospital. @entity1 : 95 adult @entity1 . INTERVENTIONS: @entity1 were preoperatively screened and classified for present @entity2144 (high-risk and low-risk group) according to a specially designed screening questionnaire. Anesthesia and surgery in the high-risk group were performed strictly avoiding latex-containing materials. The low-risk group (other @entity566 including @entity2023 ) received routine treatment, without latex-avoidance. Effects of latex avoidance or exposure were evaluated by measuring specific IgE titers perioperatively. MEASUREMENTS AND MAIN RESULTS: According to the questionnaire, 45 @entity1 at high risk were defined. Validity of classification of high-risk @entity1 is supported by significantly higher total IgE and latex and grass profilin specific IgE compared to the low-risk group. There were no significant differences in other profilin-specific IgEs. In one case of severe anaphylactic reaction a drop of latex-specific IgE during surgery could be observed. CONCLUSION: The questionnaire allowed the identification of most @entity1 at high risk for @entity2144 . In @entity2023 no changes in any specific IgE levels were detectable. Strict avoidance of perioperative latex exposure in high-risk @entity1 increases safety during anesthesia and surgery.
