Hormonal contraceptives and XXXX tolerance. II. Influence of medroxyprogesterone acetate and chronic oral contraceptives.

@entity1 @entity8097 @entity2690 @entity1735 @entity2124 @entity413
@entity413 tolerance in a group of @entity1 using injection of a depot progestogen (Depo Provera 150) for 7 months and in a group who had used various types of oral contraceptives (OCs) for at least 3 years were done to help understand the clinical significance of the reported changes. After 4 months of Depo Provera treatment there was no significant change in @entity413 or @entity2690 levels from protreatment levels. After 7 months, the mean basal @entity413 level was significantly higher than pretreatment (p.01). OGTT glycemia levels were not significantly higher (p.01) than pretreatment and fasting serum triglycerioles were decreased. @entity2124 levels were significantly lowered (p.01) from pretreatment levels. In the group using oral contraceptives, early @entity2690 levels after a @entity413 load were lower (p.01) in @entity1 treated with OCs than in controls. Borderline abnormal mean @entity413 assimilation levels (K) were seen in 11 @entity1 of the 80 studied. This was not significantly different from the control group. The group using Neogynon showed the highest @entity2690 levels of all subgroups. It is suggested that the @entity8097 derivatives may play a role in the impairment of @entity1735 metabolism.
