Antisense XXXX in Cancer.

@entity7286 @entity9135 @entity1472 @entity2451 @entity23436 @entity20927 @entity63604 @entity4632
NFKB: is a pleiotropic transcription factor that participates in the induction of various cellular and viral genes (for a review, see refs. 1 and 2). The principal form of this active complex is composed of two polypeptides, @entity9135 (recently renamed @entity9135 ) and @entity2451 (recently renamed @entity2451 ) (3, 4). Both of these sub-units belong to the rel famtly of transcription factors with homology in the @entity1472 terminus (5, 6). Since the original identification of these factors, several others have been identified in this family of transcription factors: @entity63604 , @entity4632 , @entity7286 , @entity23436 , dorsal, @entity20927 , and @entity2451 (1). The NF-kheterodimer is associated in the cytoplasm with the IkB subunit, which sequesters this factor in an inactive state (7). On activation by various stimuli, the IkB subunit separates from the active NFheterodimer, and the active complex is translocated to the nucleus where it binds to its nuclear DNA target sequence (Fig. 1). The principal cause for disassociation of IkB from NFis phosphorylation (8), but it may involve proteolysis of IkB (9) Several autoregulatory loops have been proposed for the involvement of NF-kB in the regulation of the inhibitor IkB. Furthermore, NF-kB has been shown to regulate the transcription of IkB and @entity2451 (10-12). Fig. 1. NF-K: B transcription factor. This figure depicts the basis for the function of the NF-K: B transcription factor. The principal form of the NF-K: B transcription complex is as a heterodimer composed of the two subunits: @entity9135 and @entity2451 . The inactive complex is sequestered in the cytoplasm associated with the inhibitor protein, IK: B. On activation, the IK: B protein separates from the active complex through a mechanism involving the phosphorylation and proteolysis Of IK: B. The active NF-K: B complex is then translocated to the nucleus where it binds DNA in a sequence-specific manner and interacts with the transcriptional machinery to modulate the rate of transcription of target genes.
