Effect of oral @entity2983 on inflammatory response in acute uncomplicated XXXX .

@entity1 @entity32 @entity490 @entity4436 @entity2983 @entity1851
AIM: To evaluate the impact of @entity2983 administration on inflammatory response in acute uncomplicated @entity4436 . METHODS: We conducted a single centre retrospective cohort study on @entity1 admitted to our surgical department between January 2012 and May 2014 with a computed tomography -confirmed diagnosis of acute uncomplicated @entity4436 . A total of 50 @entity1 were included in the analysis, 20 (study group) had received 3.2 g/d of @entity2983 starting from the day of admission in addition to the usual standard treatment, 30 (control group) had received standard therapy alone. Data was retrieved from a prospective database. Our primary study endpoints were: @entity1851 mean levels over time and their variation from baseline (  CRP) over the first three days of treatment. Secondary end points included: mean white blood cell and neutrophile count over time, time before regaining of regular bowel movements (passing of stools), time before reintroduction of food intake, intensity of lower @entity490 over time, analgesic consumption and length of hospital stay. RESULTS: @entity1 characteristics and inflammatory parameters were similar at baseline in the two groups. The evaluation of CRP levels over time showed, in treated @entity1 , a distinct trend towards a faster decrease compared to controls. This difference approached statistical significance on day 2 (mean CRP 6.0 +/- 4.2 mg/dL and 10.0 +/- 6.7 mg/dL respectively in study group vs controls, P = 0.055).   CRP evaluation evidenced a significantly greater increment of this inflammatory marker in the control group on day 1 (P = 0.03). A similar trend towards a faster @entity32 was observed evaluating the total white blood cell count. Neutrophile levels were significantly lower in treated @entity1 on day 2 and on day 3 (P < 0.05 for both comparisons). @entity2983 administration was also associated with an earlier reintroduction of food intake (median 1.5 d and 3 d, study group vs controls respectively, P < 0.001) and with a shorter hospital stay (median 5 d and 5.5 d, study group vs controls respectively, P = 0.03). CONCLUSION: Despite its limitations, this study suggests that @entity2983 may allow for a faster recovery and for a reduction of inflammatory response in acute uncomplicated @entity4436 .
