Intramyocardial adrenergic activation in chagasic @entity296 and XXXX .

@entity1 @entity296 @entity453 @entity67 @entity1063
BACKGROUND: Myocardial @entity1063 is altered in left @entity67 . In @entity1 with @entity296 ( @entity296 ), this issue has not been addressed. OBJECTIVE: To determine the level of myocardial @entity1063 in @entity1 with @entity296 and compare it in @entity1 with @entity453 , and to relate myocardial @entity1063 to left ventricular ejection fraction (LVEF). METHODS: We studied 39 @entity1 with @entity296 , divided into group 1: 21 individuals with normal LVEF and group 2: 18 individuals with decreased LVEF. Seventeen @entity1 with @entity453 were divided into group 3: 12 individuals with normal LVEF and group 4: 5 individuals with decreased LVEF. Two-dimensional echocardiography was used to measure LVEF. Myocardial @entity1063 was determined by high-performance liquid chromatography. RESULTS: Myocardial @entity1063 in @entity296 with and without @entity67 was 1.3  1.3 and 6.1  4.2 pg/ g noncollagen protein, respectively (p<0.0001); in @entity453 with and without @entity67 , it was 3.3  3.0 and 9.8  4.2 pg/ g noncollagen protein, respectively (p<0.0001). A positive correlation was found between LVEF and myocardial @entity1063 concentration in the @entity1 with @entity296 (p<0.01, r = 0.57) and also in those with @entity453 (p<0.01, r=0.69). A significant difference was demonstrated between @entity1063 concentrations in @entity1 with normal LVEF (groups 1 and 3; p = 0.0182), but no difference was found in @entity1 with decreased LVEF (groups 2 and 4; p = 0.1467). CONCLUSION: In @entity1 with @entity296 and normal global ejection fraction there is an early cardiac denervation, when compared to @entity453 @entity1 .
