Influence of treatment with gum acacia on renal vascular responses in a XXXX model of @entity740 .

@entity8 @entity1133 @entity3542 @entity1854 @entity1507 @entity740 @entity5536 @entity2647 @entity1011 @entity35 @entity414 @entity6634 @entity934
OBJECTIVE: This study was conducted in order to investigate the effects of @entity5536 -induced @entity740 ( @entity740 ) on renal blood flow and biochemical changes in @entity35 , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: @entity740 was induced by feeding @entity35 with @entity5536 (0.25% w/w, five weeks). Concomitantly, some of these @entity35 were also given gum acacia (GA) (15% w/v in the drinking water).   Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized @entity35 preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: @entity5536 -induced @entity740 significantly impaired the vasopressor actions of @entity934 , @entity1854 and @entity2647 and concomitant treatment with GA abated these responses. Additionally,   plasma concentrations of @entity1133 , @entity1011 , @entity414 , @entity6634 , @entity3542 and @entity1507 and urinary excretion of protein were all significantly increased by @entity5536 . GA significantly mitigated the severity of @entity5536 - induced changes. CONCLUSIONS: @entity5536 -induced @entity740 in @entity35 significantly @entity8 responses to @entity934 , @entity1854 and @entity2647 and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of @entity740 .
