Caregiver burden in atypical @entity303 : comparing frontotemporal @entity303 , Creutzfeldt-Jakob disease, and XXXX .

@entity1 @entity146 @entity303 @entity13895 @entity195 @entity4943
BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity303 and a known contributor to institutionalization of @entity1 with @entity303 . Published data have documented increased caregiver burden in @entity146 ( @entity146 ) compared to @entity195 ( @entity195 ). Another atypical @entity303 with high-perceived caregiver burden is @entity13895 ( @entity13895 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity303 etiologies. METHODS: 76 adults with atypical @entity303 (young-onset @entity195 [YOAD], @entity146 , language variant @entity4943 [lvFTD], and @entity13895 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity146 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity303 etiologies, with @entity146 and @entity13895 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity146 and @entity13895 (p = 0.002), with @entity13895 and @entity146 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity13895 and @entity146 . CONCLUSIONS: This study demonstrates that @entity146 and @entity13895 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity146 and @entity13895 are disease specific and possibly related to @entity146 .
