Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in @entity35 with salt-induced XXXX .

@entity1 @entity101 @entity918 @entity2515 @entity1219 @entity2514 @entity1372 @entity1854 @entity1424 @entity7102 @entity35 @entity65 @entity934
Endothelium-dependent responses are impaired in various models of @entity101 . The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant @entity35 (DR) on a high or low @entity1372 diet. The @entity35 were given either a diet containing 8% @entity1219 or 0.1% @entity1219 for 8 weeks or a diet containing 8% @entity1219 and a combination of @entity2515 , @entity918 , and @entity2514 for 8 or 2 weeks. DS on the 8% @entity1219 diet developed @entity101 , while the other @entity35 did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed @entity101 in DS and lowered blood pressure in DR on the 8% @entity1219 diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, @entity934 , @entity1424 , and @entity7102 caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% @entity1219 compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, @entity1854 . These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of @entity65 in @entity1 with @entity101 .
