The effect of chronic emotional stress on the humoral immune response to XXXX in @entity19 .

@entity1642 @entity32 @entity630 @entity19 @entity6527 @entity281 @entity702 @entity166 @entity9749 @entity2523
Previous studies have shown that @entity1642 plays a significant role in the outcome of @entity166 , but data related to the effect of stress on periodontal @entity281 is limited. The present study was designed to test the impact of emotional stress on the humoral immune response to the periodontal pathogen @entity2523 in a @entity19 model of @entity32 . Chambers constructed from @entity702 wire were implanted in the subcutaneous dorsolumbar region of @entity19 . All @entity19 were immunized with @entity2523 followed by an intrachamber challenge with the bacteria. One group of @entity19 was used as control, while the other two experienced experimental stress conditions (isolation/restraint stress). Stress-1 group was stressed during the immunization period, while Stress-2 group was stressed during the local challenge period. Chamber exudates and serum were collected and analyzed for levels of anti-P. gingivalis antibodies (IgG, @entity6527 and @entity9749 ). The levels of serum antibodies to @entity2523 were not different between the three tested groups, excluding increased levels of @entity9749 in Stress-1 group at baseline. The levels of antibodies in the chamber exudates were significantly lower in the stressed groups at baseline, but higher at d 7. The @entity6527 to @entity9749 ratio was significantly higher in the control group compared with the two stressed groups. The findings of the present study suggest that chronic @entity1642 had a marked impact on the localized response to @entity2523 challenge. The lower @entity6527 / @entity9749 ratio observed in the stress groups suggests elevated @entity630 response during stress.
