Decreased NK cell functions in XXXX can be reactivated by fat mass reduction.

@entity1 @entity379 @entity5 @entity28
OBJECTIVE: Natural killer (NK) cells are the first defense against malignant cells, and their functions are severely impaired in individuals with @entity28 . However, it is not known whether functions can be re-activated after weight loss. The alterations of NK cell functions after fat mass reduction were investigated. METHODS: Thirty-two healthy adults with @entity28 were divided into control and experimental groups. @entity1 of the experimental group performed a 3-month program of exercise training and nutrition. Anthropometric, physiological, and metabolic parameters and plasma adipocytokines were determined. Peripheral blood mononuclear cells were analyzed by means of flow cytometry and Western blot assay for various NK cell-specific functional parameters and leptin signaling components. NK cell-mediated cytotoxicity assay with leptin stimulation was performed. RESULTS: Male @entity1 significantly decreased their body fat mass (P   <   0.05) and increased physical fitness (P   <   0.05). Plasma leptin levels were significantly reduced (P   <   0.05) and intracellular @entity379 ) expression in CD56(dim) NK cells was significantly increased (P   <   0.001) 3 months after study end. Stimulation of @entity1 cells with different leptin dosages revealed a significant dose-dependent decrease of specific @entity5 cell lysis. CONCLUSIONS: The present study demonstrates a reactivation of NK cell functionality after body fat mass reduction in @entity1 with @entity28 .
