@entity19 XXXX decreases hemopoietic stem cells.

@entity14190 @entity21552 @entity308 @entity417 @entity19 @entity281 @entity5895 @entity311 @entity2637
The causes of @entity417 and immunosuppression, major outcomes of @entity311 , are not well established. This study was undertaken to investigate whether @entity14190 ( @entity14190 ) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of @entity281 . Groups of female Balb/c @entity19 infected with @entity21552 vinckei vinckei, @entity2637 , or @entity21552 adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. Plasma samples were collected for @entity14190 bioassay and radioimmunoassay (RIA). Using radioiron incorporation as an index of erythropoiesis, differences in response to @entity281 with different species of plasmodia were observed. In general, decreases in erythropoietic activity were observed in bone marrow and spleen as the @entity281 progressed and continued to be @entity308 after apparent resolution of a nonlethal @entity281 with @entity21552 adami. Marrow from infected and control femurs were tested for CFU-S content using the spleen colony assay. The cellularity and CFU-S content of the femoral marrow decrease as the @entity5895 increases. All three species of plasmodia stimulate @entity14190 production during peak @entity5895 , indicating that adequate amounts of @entity14190 are available to the erythron during @entity281 . Depletion of CFU-S and probable lack of compensatory turnover of CFU-S may contribute to the disease characteristics of @entity311 .
