The iron-binding and XXXX radical scavenging action of anti-inflammatory drugs.

@entity32 @entity8798 @entity274 @entity5230 @entity3522 @entity500 @entity2361 @entity6383 @entity3787 @entity12433 @entity503 @entity2145
1. @entity3787 radicals (. @entity2145 ) are thought to be generated at sites of @entity32 and to contribute to tissue damage. All anti-inflammatory drugs tested were able to scavenge . @entity2145 generated in free solution at almost diffusion-controlled rates (rate constants about 10(10)M-1s-1). 2. Much . @entity2145 generation in vivo occurs at specific sites, where bound metal ions (such as @entity8798 ) react with @entity274 to produce . @entity2145 that immediately attacks the site. Only . @entity2145 scavengers that have sufficient metal-binding ability to withdraw metal ions from this site can protect against site-specific damage. 3. All anti-inflammatory drugs tested were able to protect against site-specific damage by . @entity2145 in a simple model system in vitro. @entity2361 , @entity3522 , @entity5230 , @entity500 , @entity12433 , @entity503 and @entity6383 were especially effective. 4. The ability of an anti-inflammatory drug to protect against . @entity2145 formation in vivo depends not only on its rate constant for reaction with @entity2145 , but also on its metal-binding ability and on the geometry and redox potential of any metal complex formed.
