Mitochondrial @entity4975 dehydrogenase in XXXX -reperfusion injury: from bench to bedside.

@entity296 @entity5721 @entity301 @entity1188 @entity3125 @entity453 @entity741 @entity299 @entity583 @entity943 @entity4975 @entity6921 @entity3094
Acute @entity583 is one of the major causes of mortality worldwide. Reperfusion in a timely fashion is the most effective way to limit @entity1188 size. However, reperfusion can itself prompt further @entity296 . This phenomenon is commonly known as @entity741 -reperfusion (IR) injury. Mitochondrial @entity4975 dehydrogenase ( @entity6921 ) is an enzyme metabolizing @entity3094 and toxic @entity3125 . Increasing evidence has revealed a cardioprotective role of @entity6921 in @entity741 . Evidence from animal studies has shown that @entity6921 diminishes acute @entity583 size, ameliorates @entity299 and prevents reperfusion @entity943 . The activity of @entity6921 is severely compromised if it is encoded by the mutant @entity6921 *2 gene, with an incidence of approximately 40% in Asian populations. Epidemiological surveys in the Asian population have depicted that @entity6921 polymorphism is closely associated with higher prevalence of @entity583 and @entity453 . Therefore, targeting @entity6921 may represent a promising avenue to protect against @entity5721 . This review recapitulates the underlying mechanisms involved in the protective effect of @entity6921 in @entity5721 . Translational potential of @entity6921 in the management of @entity301 is also discussed.
