Hirsutella sinensis mycelium attenuates XXXX -induced @entity55 and @entity82 in vivo.

@entity1 @entity82 @entity1356 @entity19 @entity5704 @entity26 @entity55 @entity1970 @entity651 @entity8923 @entity2533 @entity1732 @entity224
UNASSIGNED: Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses @entity1356 and @entity8923 secretion by inhibiting both canonical and non-canonical inflammasomes in @entity1 macrophages. However, whether HSM may be used to prevent @entity82 and the mechanism underlying this activity remain unclear. Our results show that pretreatment with HSM inhibits @entity2533 -induced expression of fibronectin and @entity1970 in lung fibroblasts. HSM also restores @entity224 dismutase expression in @entity2533 -treated lung fibroblasts and inhibits reactive @entity26 species production in lung epithelial cells. Furthermore, HSM pretreatment markedly reduces @entity1732 -induced @entity651 and @entity82 in @entity19 . Accordingly, HSM reduces inflammatory cell accumulation in bronchoalveolar lavage fluid and proinflammatory cytokines levels in lung tissues. The HSM extract also significantly reduces @entity2533 in lung tissues, and this effect is accompanied by decreased collagen 3a1 and @entity1970 levels. Moreover, HSM reduces expression of the @entity5704 inflammasome and P2X7R in lung tissues, whereas it enhances expression of @entity224 dismutase. These findings suggest that HSM may be used for the treatment of @entity55 and @entity82 .
