Benign childhood @entity302 with centrotemporal spikes and electroencephalography trait are not linked to @entity15748 and @entity15749 of XXXX .

@entity11529 @entity410 @entity15749 @entity15748 @entity1654 @entity302 @entity74 @entity923 @entity734
PURPOSE: The electroencephalographic hallmark of benign childhood @entity302 with centrotemporal spikes (BECTS, or @entity1654 ) are characteristically shaped centrotemporal spikes and sharp waves ( @entity923 ). This EEG trait, but not BECTS itself, has been reported to follow an autosomal dominant mode of inheritance with incomplete penetrance and age @entity734 . @entity923 therefore represents a neurobiologic marker for the increased risk of developing BECTS. @entity11529 ( @entity11529 ) like BECTS is an idiopathic age-dependent @entity302 with a benign course. Observations of @entity410 and BECTS in the same individual are well documented. @entity410 with benign course were found in increased numbers in a series of @entity923 carriers. Two genetic loci, @entity15748 and @entity15749 , have been mapped in families with @entity11529 , making these two loci strong candidates for the @entity923 trait underlying BECTS. The aim of this study was to determine whether these two @entity302 are @entity74 . METHODS: Linkage analysis was performed in 12 families with probands with BECTS and one or more relatives with @entity923 in the EEG with or without BECTS by using polymorphic DNA markers. RESULTS: Assuming an autosomal mode of inheritance with penetrances of 0.9 and 0.45, respectively, both loci were consistently excluded. CONCLUSIONS: The @entity923 trait and @entity15748 and @entity15749 segregate independently. BECTS and @entity11529 therefore appear to be genetically distinct entities. @entity410 may be a underrecognized symptom of the @entity923 trait itself.
