Fas-related apoptosis in XXXX .

@entity1 @entity353 @entity5 @entity1195 @entity12 @entity356
The aims of this study were to determine whether @entity1 @entity356 express @entity12 or Fas, whether @entity12 expression is associated with increased apoptotic induction, especially, @entity5 -infiltrating lymphocyte (TIL) and whether apoptotic induction is associated with the @entity5 stage and histologic type. Early @entity356 (EGC) (n=38) and advanced @entity356 (AGC) (n=61) cases were analyzed in @entity1 who received gastric resection from 1997 to 1998. There were 38 diffuse type and 61 intestinal type cases. Immunohistochemical staining for Fas, @entity12 and @entity1195 , TACS trade mark in situ apoptosis detection kit, and double staining with the observation under a confocal scanning laser microscope were employed. @entity12 was localized to neoplastic cells in 23 cases (61%) of EGC group and 40 cases (66%) of AGC group. The extent of @entity12 expression was variable, with both @entity12 -positive and -negative neoplastic regions occurring within @entity5 . TILs were detected by @entity1195 , and apoptosis of TILs as detected by co-expression of @entity1195 and TACS on serial histologic sections. TILs adjacent to @entity12 expressing @entity5 regions were decreased in number and TILs adjacent to @entity12 -negative @entity5 regions were increased in number; apoptotic induction of TIL showed the opposite pattern (p<0.05). Fas was expressed homogeneously throughout the @entity5 masses independent of the @entity5 stage. Fas expression in 39 cases (64%) was intestinal type and in 26 cases (68%), diffuse type. Labeling indices for tumoral apoptosis in EGC and AGC were 6.72% and 7.13%, respectively. Co-expression of @entity12 and Fas, which occurrs over large areas of the @entity5 , did not result in an enhanced rate of @entity5 cell apoptosis. In addition, @entity5 stage and other prognostic factors were not associated with Fas and @entity12 expressions, number of TIL and apoptotic induction. A statistically significant @entity353 concomitant with significantly increased TIL apoptosis adjacent to @entity12 -expressing regions of @entity356 were demonstrated. This finding suggests Fas-mediated apoptotic depletion of TIL in response to @entity12 expression in @entity5 , and provides evidence to support the Fas counterattack theory as a mechanism of immune escape in @entity356 . Furthermore, @entity356 cells of the intestinal and the diffuse type did not differ in their expression of the Fas-apoptotic system.
