A strong correlation between glomerular filtration rate and filtration surface in XXXX .

@entity1 @entity6 @entity4295 @entity2316 @entity1184 @entity633
Quantitative structural studies were performed in kidney biopsy specimens from 24 long-term Type 1 (insulin-dependent) @entity6 @entity1 with persistent @entity633 due to @entity2316 . Ten @entity1 were receiving antihypertensive treatment, and among the remaining @entity1 the mean blood pressure was 142/91 mm Hg (SD = 11/9). The urinary albumin excretion rate showed a range from 100 to 5494 micrograms/min (geometric mean 688 micrograms/min.) Glomerular filtration rate also showed a wide range, from supranormal to markedly decreased values (128 to 28 ml.min-1. (1.73 m2)-1, mean 75). The filtration surface (interface between capillary and urinary space) per total number of @entity4295 (open + occluded) was estimated by combined light-and electron microscopy. The percentage occluded glomeruli as well as structural quantities in the open glomeruli were taken into account in this estimate. A highly significant correlation was seen between glomerular filtration rate and filtration surface per nephron (r = 0.77, p less than 10(-4). The percentage occluded glomeruli contributed significantly to the variation in glomerular filtration rate (for this relationship tested separately r = -0.78, p less than 10(-5). The volume of open glomeruli was even larger than that seen in early @entity2316 and tended to increase with the percentage of glomerular closure, indicating that a @entity1184 might have taken place. In the open glomeruli the filtration surface constituted a smaller percent of total capillary surface (the remaining part facing the mesangial regions) than in early @entity6 @entity1 and control subjects. Our study has demonstrated that reduced glomerular filtration surface is closely associated with reduced glomerular filtration rate in Type 1 @entity6 @entity1 with @entity2316 .
