Photochemically induced cortical @entity1188 in the XXXX . 1. Time course of hemodynamic consequences.

@entity1 @entity308 @entity64 @entity63 @entity450 @entity854 @entity1188 @entity35 @entity717
Alterations in local CBF (LCBF) were assessed autoradiographically in the @entity35 at several time points following photochemically induced cortical @entity1188 . Cortical @entity1188 of consistent size and location was produced by irradiating the brain with green light through the intact skull for 20 min following the systemic injection of rose bengal. A consistent pattern of altered LCBF was recorded in both @entity717 regions over the course of the study. At 30 min, a severely @entity63 zone surrounded by regions of cortical @entity450 was apparent. LCBF was also @entity308 relative to control values in ipsilateral cortical regions remote from the irradiated area, while contralateral cortical structures were mildly hyperemic. By 4 h, the zone of severe @entity63 had enlarged and its margins were no longer hyperemic. Ipsilateral cortical and some subcortical structures demonstrated significantly @entity308 levels of LCBF. At 5 days, LCBF throughout both ipsilateral and contralateral cortices was @entity308 compared with control values. By 15 days, LCBF had returned to control levels in most brain structures shown histopathologically not to be irreversibly damaged. The temporal sequence and magnitude of these hemodynamic alterations are consistent with findings in clinical studies in which repeated measurements of CBF have been carried out in @entity1 with @entity64 . The ability to produce a cortical @entity1188 that results in a consistent pattern of altered CBF should facilitate the investigation of @entity64 mechanisms responsible for these @entity854 .
