Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel XXXX -rich berry extract formula.

@entity1 @entity137 @entity274 @entity7 @entity5 @entity310 @entity26 @entity2695 @entity2842 @entity4211
Edible berry @entity4211 possess a broad spectrum of therapeutic and anti-carcinogenic properties. Berries are rich in @entity4211 , compounds that provide pigmentation to fruits and serve as natural antioxidants. @entity4211 repair and protect genomic DNA integrity. Earlier studies have shown that berry @entity4211 are beneficial in reducing age-associated oxidative stress, as well as in improving neuronal and cognitive brain function. Six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry) were studied for antioxidant efficacy, cytotoxic potential, cellular uptake, and anti-angiogenic (the ability to reduce unwanted growth of blood vessels, which can lead to varicose veins and @entity5 formation) properties. We evaluated various combinations of edible berry extracts and developed a synergistic formula, OptiBerry IH141, which exhibited high ORAC ( @entity26 -Radical Absorbing Capacity) value, low @entity137 , and superior anti-angiogenic properties compared to the other combinations tested. @entity5 represent a priority area in @entity5 biology. OptiBerry significantly inhibited both @entity274 - and @entity310 -induced @entity7 ( @entity7 ) expression by @entity1 keratinocytes. @entity7 is a key regulator of @entity5 angiogenesis. Matrigel assay using @entity1 microvascular endothelial cells showed that OptiBerry impaired angiogenesis. In an in vivo model of angiogenesis, OptiBerry significantly inhibited basal @entity2842 and inducible NF-kappaB transcriptions. Endothelioma cells pretreated with OptiBerry showed a diminished ability to form @entity2695 and markedly decreased @entity5 growth by more than 50%. In essence, these studies highlight the novel anti-angiogenic, antioxidant, and anti-carcinogenic potential of a novel @entity4211 -rich berry extract formula, OptiBerry.
