@entity788 : A single-center 20-year experience with 100 XXXX .

@entity1 @entity788 @entity5 @entity3508 @entity880 @entity3270
BACKGROUND/OBJECTIVES: @entity788 (NENs) are rare @entity5 , exhibiting several morphological, functional, and behavioral characteristics. However, only few reports have evaluated large case series of pancreatic NEN. METHODS: We conducted a retrospective review of 100 consecutive @entity1 with pancreatic NEN diagnosed pathologically and treated at the National @entity5 Center Hospital between 1991 and 2010. RESULTS: The study included 48 males and 52 females (median age: 55 years). Fourteen @entity1 had clinical symptoms caused by excess hormone secretion at diagnosis. Twelve @entity1 were diagnosed with @entity5 ( @entity5 ) G1, 54 with @entity5 G2, and 32 with @entity3270 ( @entity3270 ) as per the 2010 World Health Organization classification. Distant metastases were observed in 25%, 43%, and 84% of the @entity1 with @entity5 G1, @entity5 G2, and @entity3270 , respectively. Serum levels of @entity3508 and @entity880 dehydrogenase significantly increased in @entity1 with @entity3270 compared with those in @entity1 with @entity5 G1/G2. The 5-year survival rates of @entity1 with @entity5 G1, @entity5 G2, and @entity3270 were 91%, 69%, and 10%, respectively. Good performance status (PS), lower stage, and histopathological grade were identified as independent favorable prognostic factors. CONCLUSIONS: @entity1 with @entity5 G1/G2 treated with surgical resection had a good prognosis. Most @entity1 with @entity3270 exhibited distant metastases and had a poor prognosis. Staging classification and the WHO 2010 grading are important factors for selecting the appropriate treatment strategy and predicting prognosis for @entity1 with pancreatic NEN.
