Pathology of late-onset XXXX @entity296 .

@entity1 @entity32 @entity296 @entity82 @entity8253 @entity4349 @entity39 @entity384 @entity1711 @entity1283 @entity1710 @entity204 @entity1370
INTRODUCTION: @entity8253 are known to have acute @entity1370 . @entity4349 -induced @entity384 may have late onset and present years after administration of the drug. Several studies have described the clinical findings in @entity1 with late-onset @entity296 , including electrocardiography, exercise testing, echocardiography, and histological findings in endomyocardial biopsies; however, there is little information on the pathological changes that are found in explanted or autopsy hearts. METHODS: We reviewed the medical records and microscopic slides of heart tissue from one @entity1 who had an autopsy and from nine @entity1 who had cardiac transplants between 2001 and 2008. Heart weights were compared to historic controls (heart weights normalized for the @entity1 's heights). @entity1710 and @entity1711 (H_E)-stained slides were semiquantitated for evidence of @entity39 , myocytolysis, @entity82 , replacement @entity82 , and the presence of @entity32 . RESULTS: The average heart weight ranged from 231 to 470 g (mean=317    65 g, median=303 g). Review of the histological sections revealed no evidence of significant @entity39 or myocytolysis. Interstitial @entity82 was identified in all 10 @entity1 , with six @entity1 showing multifocal @entity82 , three @entity1 showing diffuse @entity82 , and only one @entity1 showing focal @entity82 . Replacement @entity82 was identified in six @entity1 , with two @entity1 displaying multifocal and four @entity1 displaying focal replacement @entity82 . CONCLUSION: Late-onset @entity296 is a serious consequence of @entity4349 therapy resulting in @entity204 or the need for cardiac transplantation in some @entity1 . Unlike most other forms of @entity384 , the major pathological changes appear to be interstitial and/or replacement @entity82 without significant @entity1283 .
