Effectiveness of preoperative autologous blood donation for protection against allogeneic blood exposure in XXXX surgeries: a propensity-matched cohort analysis.

@entity1 @entity2737 @entity299 @entity85 @entity166
UNASSIGNED: OBJECT The goal of this study was to examine the effectiveness of preoperative autologous blood donation (PABD) in @entity85 ( @entity85 ) surgery. METHODS @entity1 undergoing single-stay @entity85 reconstructions were identified in a multicenter database. @entity1 were divided into groups according to PABD (either PABD or NoPABD). Propensity weighting was used to create matched cohorts of PABD and NoPABD @entity1 . Allogeneic (ALLO) exposure, autologous (AUTO) wastage (unused AUTO), and complication rates were compared between groups. RESULTS Four hundred twenty-eight @entity1 were identified as meeting eligibility criteria. Sixty @entity1 were treated with PABD, of whom 50 were matched to 50 @entity1 who were not treated with PABD (NoPABD). Nearly one-third of @entity1 in the PABD group (18/60, 30%) did not receive any autologous transfusion and donated blood was wasted. In 6 of these cases (6/60, 10%), @entity1 received ALLO blood transfusions without AUTO. In 9 cases (9/60, 15%), @entity1 received ALLO and AUTO blood transfusions. Overall rates of transfusion of any type were similar between groups (PABD 70% [42/60], NoPABD 75% [275/368], p = 0.438). Major and minor in-hospital complications were similar between groups (Major PABD 10% [6/60], NoPABD 12% [43/368], p = 0.537; Minor PABD 30% [18/60], NoPABD 24% [87/368], p = 0.499). When controlling for potential confounders, PABD @entity1 were more likely to receive some transfusion (OR 15.1, 95% CI 2.1-106.7). No relationship between PABD and ALLO blood exposure was observed, however, refuting the concept that PABD is protective against ALLO blood exposure. In the matched cohorts, PABD @entity1 were more likely to sustain a major perioperative @entity299 (PABD 8/50 [16%], NoPABD 1/50 [2%], p = 0.046). No differences in rates of @entity2737 were observed between cohorts. CONCLUSIONS Preoperative autologous blood donation was associated with a higher probability of perioperative transfusions of any type in @entity1 with @entity85 . No protective effect of PABD against ALLO blood exposure was observed, and no risk of perioperative @entity166 complications was observed in @entity1 exposed to ALLO blood only. The benefit of PABD in @entity1 with @entity85 remains undefined.
