Effects of XXXX priming on cortical high beta and high gamma oscillatory activity in a rodent model of @entity191 .

@entity2194 @entity3034 @entity11640 @entity935 @entity10432 @entity10097 @entity910 @entity191 @entity750 @entity10098 @entity35
UNASSIGNED: Prolonged @entity3034 treatment in @entity191 ( @entity191 ) often leads to the expression of @entity910 known as @entity3034 -induced @entity910 . Recently, dramatic 80Hz oscillatory @entity2194 ( @entity2194 ) activity within the primary motor cortex has been linked to @entity910 in a rodent model of @entity191 and attributed to stimulation of cortical @entity935 D1 receptors. To characterize the relationship between high gamma (70-110Hz) cortical activity and the development of @entity3034 -induced @entity910 , cortical @entity2194 and spike signals were recorded in hemiparkinsonian @entity35 treated with @entity3034 for 7days, and @entity910 was quantified using the @entity910 ( @entity910 ) scale. The relationship between high gamma and @entity910 was further probed by assessment of the effects of pharmacological agents known to induce or modulate @entity910 expression. Findings demonstrate that @entity910 and high gamma @entity2194 power increase between days 1 and 7 of @entity3034 priming. Notably, high beta (25-35Hz) power associated with @entity191 decreased as @entity910 and high gamma @entity2194 power increased during priming. After priming, @entity35 were treated with the D1 agonist @entity10432 and the D2 agonist @entity11640 . Both @entity935 agonists independently induced @entity910 and high gamma cortical activity that were similar to that induced by @entity3034 , showing that this @entity2194 activity is neither D1 nor D2 receptor specific. The @entity750 1A receptor agonist @entity10097 reduced @entity3034 - and DA agonist-induced @entity910 and high gamma power to varying degrees, while the @entity750 1A antagonist @entity10098 reversed these effects. Unexpectedly, as cortical high gamma power increased, phase locking of cortical pyramidal spiking to high gamma oscillations decreased, raising questions regarding the neural substrate(s) responsible for high gamma generation and the functional correlation between high gamma and @entity910 .
