A comparison of the muscarinic antagonist actions of @entity6305 and XXXX .

@entity1169 @entity2515 @entity8651 @entity6305 @entity591 @entity3897 @entity4140 @entity35 @entity1168
1 In the pithed @entity35 , muscarine (2.5-10 microgram/kg i.v.) normally produced @entity1168 , but @entity591 were seen in the presence of @entity6305 (0.1-1.0 mg/kg i.v.) and @entity8651 (0.1-5.0 mg/kg i.v.). 2 The @entity591 was probably a result of muscarinic receptor stimulation, because it was antagonized by @entity3897 (10 microgram/kg i.v.) and @entity4140 (10-30 microgram/kg i.v.). The location of these muscarinic receptors is probably within the sympathetic ganglia since the @entity591 were inhibited by pretreatment with @entity1169 (1 mg/kg i.v.) or @entity2515 (5 mg/kg i.p. 24 h prior to study). 3 In the @entity35 isolated atria preparation, @entity6305 was 86 times more potent as an antagonist of the effects of muscarine than in the @entity35 isolated superior cervical ganglion. The mechanism of action in both tissues may be non-competitive. 4 @entity6305 selectivity antagonized atrial inhibitory muscarinic responses compared to excitatory muscarinic responses in sympathetic ganglia in the @entity35 .
