Epidemiological and pathobiological profiles of XXXX infections: review of consecutive series of 33 cases over a 13-year period.

@entity1 @entity295 @entity82 @entity66 @entity5 @entity3168 @entity281 @entity2142 @entity2259
BACKGROUND: Although @entity3168 ( @entity3168 ) is well known as the causative agent of several forms of @entity66 , precise epidemiological and pathobiological aspects are still unknown. METHODS: We retrospectively reviewed the culture results of samples collected in our hospital from 2001 through 2013. In addition, for the detection and toxinogenic typing of @entity3168 , polymerase-chain-reaction amplification (PCR)-based rapid analysis was performed in 6 cases using DNA extracted from paraffin-embedded tissues. RESULTS: A total of 35 samples from 33 cases were positive for @entity3168 , representing an incidence of 0.017% (35/205, 114). Among 33 @entity1 , 21 @entity1 manifested @entity295 and 7 @entity1 had @entity2259 . One of the septic cases was complicated by fatal @entity2142 and thus, the prevalence was estimated at 3.0% among @entity3168 infections (1/33). The direct causative disease or state for @entity3168 @entity281 was identified in 18 @entity1 : surgery or intervention for @entity5 , 8 @entity1 ; chemotherapy for @entity5 , 2 @entity1 ; surgery or intervention for @entity5 , 6 @entity1 ; liver @entity82 , 3 @entity1 , etc. PCR-based toxinogenic typing of @entity3168 detected the alpha-toxin gene only in tissue from a @entity1 who died of massive @entity2142 ; none of the toxin genes could be amplified in the other 5 cases examined. CONCLUSIONS: The prevalence of overt @entity3168 @entity281 is low, but upon detection, infected @entity1 should be carefully monitored for fatal acute @entity2142 caused by type A @entity3168 . Furthermore, PCR-based rapid detection of @entity3168 and toxinogenic typing by archival pathological material is applicable as a diagnostic tool.
