Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for XXXX .

@entity1 @entity22489 @entity1819 @entity3 @entity356
OBJECTIVE: The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 ( @entity22489 -35) in cancerous tissues and clinicopathological characteristics and prognosis of the @entity1 with @entity356 ( @entity356 ). METHODS: The @entity356 samples from 157 @entity1 in a discovery cohort and 148 @entity1 in a testing cohort with follow-up data were used to validate the feasibility of expression of @entity22489 -35 protein in predicting @entity356 prognosis. Immunohistochemical staining was used to determine the expression of @entity22489 -35 protein in precancerous @entity356 . The correlation between the expression of @entity22489 -35 and clinicopathologic characteristics of @entity1 with @entity356 was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between @entity22489 -35 expression and prognosis. RESULTS: @entity22489 -35 expression was increased steadily in sequential stages of precancerous @entity1819 . Positive @entity22489 -35 expression was more frequently detected in @entity1 with distant @entity3 (P = 0.023) and III+IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of @entity22489 -35 had a significant impact on overall survival of @entity1 with @entity356 in discovery cohort (P<0.001) and testing cohort (P = 0.001). @entity22489 -35 expression was an independent prognostic indicator for the overall survival of @entity1 with @entity356 in both cohorts. CONCLUSIONS: The present research demonstrated that @entity22489 -35 over-expression was an independent factor in @entity356 prognosis. @entity22489 gene may be a useful target of interventions slowing the progression of precancerous @entity1819 and a new therapy method to improve the prognosis of @entity356 .
