Changing views on @entity66 : impact of aging, XXXX , diet, and microbiota.

@entity1 @entity697 @entity4436 @entity66 @entity28 @entity6522 @entity7261 @entity490 @entity158 @entity850 @entity1142 @entity1049
The development of @entity6522 is a common aging change in industrialized nations. While most @entity1 have asymptomatic @entity7261 , around one in five develops symptomatic @entity66 . This is characterized by recurrent @entity490 and disturbed bowel habit. Some of the @entity158 episodes are prolonged and are due to @entity697 , which itself may be complicated by abscess, perforation, fistulation, or @entity850 formation. Risk factors favouring the development of symptomatic @entity66 include @entity28 , smoking and diets low in fiber but high in red meat and animal fat. What determines the transition from asymptomatic @entity7261 to symptomatic @entity66 is unclear but neuromuscular changes following @entity697 may be responsible in some cases. The severity of symptoms generated depends on @entity158 processing which is influenced by psychosocial factors. These are important considerations in deciding optimal @entity1 management. Prior theories of the cause of @entity7261 suggested that @entity1142 was an important cause, but new data challenge this and has provoked new ideas. Underlying mechanisms causing @entity7261 include weakening of the @entity1049 . Dietary induced changes in microbiota and the host inflammatory response may underlie the subsequent development of acute/chronic @entity4436 and its sequela.
