Evidence for distinct cytokine expression in @entity56 versus nonallergic chronic XXXX .

@entity1244 @entity1 @entity1712 @entity225 @entity32 @entity566 @entity117 @entity13277 @entity379 @entity56 @entity2772 @entity1199 @entity3646 @entity1412 @entity2841
BACKGROUND: The purpose of this study was to characterize the relationship between tissue cytokine expression and the cellular infiltrate present in chronic @entity1244 with @entity1412 ( @entity13277 /NP) and to compare the immunopathology and cytokine profile of @entity1 with @entity566 versus @entity1 without @entity566 . METHODS: Nasal polyp tissue samples from 12 @entity1 with @entity13277 /NP and nasal turbinate biopsy specimens from 10 normal control @entity1 were examined for the expression of @entity3646 , @entity1199 , and @entity379 cytokine messenger RNA (mRNA) species by in situ hybridization. These data were analyzed in conjunction with data previously reported for the cytokine mRNA species @entity2841 ( @entity2841 ), @entity2772 , and @entity225 and the immunocytochemical profile of the inflammatory cell infiltrate. @entity1 with @entity566 were distinguished from those without @entity566 on the basis of @entity566 skin tests. RESULTS: Tissue @entity1712 was a prominent feature of both @entity56 and nonallergic @entity13277 /NP and correlated in both subgroups with the density of @entity2841 and @entity2772 mRNA+ cells. In comparison with normal controls, @entity1 with @entity56 @entity13277 /NP had significantly higher @entity13277 /NP had significantly higher tissue densities of @entity2841 , @entity2772 , @entity3646 , and @entity225 (p < or = 0.025). In contrast, @entity1 with nonallergic @entity13277 /NP had significantly higher tissue densities of @entity2841 , @entity2772 , and @entity379 (p < or = 0.001). The @entity56 and nonallergic subgroups showed distinct cytokine profiles with the most distinguishing cytokines of the @entity56 subgroup being @entity3646 (p = 0.001) and @entity225 (p = 0.017) and of the nonallergic subgroup being @entity379 (p = 0.004). Furthermore, @entity1 with @entity56 @entity13277 /NP showed an increased density of CD3+ T lymphocytes compared with either controls or @entity1 with nonallergic @entity13277 /NP (p = 0.03). The density of CD3+ T lymphocytes was the only significant difference between @entity1 with @entity56 and nonallergic @entity13277 /NP. A clinical history of @entity117 sensitivity was strongly correlated with nonallergic @entity13277 /NP, as well as the nonallergic @entity13277 /NP profile of cytokines, including @entity379 . CONCLUSION: We conclude that distinct mechanisms of @entity1712 exist in @entity1 with @entity56 versus nonallergic @entity13277 /NP. The @entity56 mechanism involves production of TH2-type cytokines, including @entity2841 , @entity2772 , @entity3646 , and @entity225 , by infiltrating T lymphocytes. The nonallergic mechanism remains unknown but does involve production of @entity2841 , @entity2772 , and @entity379 . However, nonallergic @entity1712 is independent of @entity3646 and @entity225 , cytokines that contribute to tissue @entity1712 in @entity32 . Aspirin sensitivity is strongly correlated with nonallergic @entity13277 /NP and production of the nonallergic @entity13277 /NP profile of cytokines, including @entity379 .
