Association analysis between the @entity23970 @entity63517 polymorphism and nonsyndromic XXXX and/or @entity2419 in a Chinese population.

@entity1 @entity63517 @entity2419 @entity3384 @entity23970
OBJECTIVE: To investigate whether an association occurred between the @entity23970 @entity63517 polymorphism and nonsyndromic @entity3384 with or without @entity2419 ( @entity2419 ) or @entity2419 only (CPO) in Chinese @entity1 . DESIGN AND SETTING: Case-controlled study at the West China Hospital of Stomatology, Sichuan University, China. SUBJECTS: A total of 91 @entity1 with @entity3384 ( @entity3384 ) and 96 unrelated, healthy individuals with no family history of @entity3384 were genotyped. METHODS: The @entity23970 @entity63517 polymorphism was genotyped by restriction digestion of polymerase chain reaction products with BseLI. Chi-square statistics were used to make case-controlled comparisons. RESULTS: The frequency of the A allele was significantly increased and the frequency of the G allele was reduced in CPO @entity1 in comparison with control subjects. The 820GG genotype had a significantly lower frequency in @entity1 with CPO than in controls, with an odds ratio of 0.25 (95% confidence interval, -0.061 to 0.57). No difference in the distribution of genotypes was noted between @entity2419 @entity1 and the total group of @entity3384 @entity1 compared with controls. CONCLUSIONS: The present findings indicate that the 820A allele is more frequent in the Chinese CPO population and may confer an increased risk for CPO in these individuals. The @entity63517 variant may be in linkage disequilibrium with other disorder-causing mutations. @entity2419 or CPO results should be analyzed separately and stratified in future studies.
