[Approach to the XXXX research].

@entity1 @entity40320 @entity303 @entity1294 @entity477 @entity195 @entity10334 @entity204 @entity528 @entity2333 @entity934
Main causes of @entity303 in the elderly are @entity1294 and @entity195 . @entity1294 is related to both amounts and localization of lesions. Recently incidence of @entity40320 ( @entity10334 ) and @entity2333 are increasing. In Alzheimer's protein chemistry of amyloid (beta protein, A4 protein) revealed its precursor @entity477 and its gene (chromosome 21), which produces protease inhibitor in the brain of @entity195 . @entity477 is considered as an membrane protein (receptor) and appears abundantly in the cerebral cortex. Immunohistochemical study showed that beta protein is observed also in normal aged brain. On the other hand, tau protein (main component of @entity195 tangle, PHF) appeared as abnormal sprouting of neurites in @entity195 . The latter may related to @entity303 and @entity204 . In @entity195 , several neurotransmitters, including @entity934 , are reduced in the brain and related structural changes are observed. Recently olfactory bulb and mucosal changes are remarked as one of pathogenesis of this disease. Delayed @entity528 is a new phenomenon of nerve cell death of vascular origin and should be studied in @entity1 @entity1294 .
