Characterisation of cell functions and receptors in @entity5815 / XXXX (CFS/ME).

@entity1 @entity404 @entity16143 @entity804 @entity2940 @entity3222 @entity3138 @entity1200 @entity1454 @entity4071 @entity5815 @entity2935 @entity32882 @entity405
BACKGROUND: Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of @entity5815 / @entity5815 (CFS/ME). The objective of this study was to investigate the functional ability of innate and adaptive immune cells in moderate and severe CFS/ME @entity1 . The 1994 Fukuda criteria for CFS/ME were used to define CFS/ME @entity1 . CFS/ME @entity1 were grouped based on illness severity with 15 moderately affected (moderate) and 12 severely affected (severe) CFS/ME @entity1 who were age and sex matched with 18 healthy controls. Flow cytometric protocols were used for immunological analysis of dendritic cells, monocytes and neutrophil function as well as measures of lytic proteins and T, natural killer (NK) and B cell receptors. RESULTS: CFS/ME @entity1 exhibited alterations in NK receptors and adhesion markers and receptors on @entity404 (+)T and @entity405 (+)T cells. Moderate CFS/ME @entity1 had increased @entity405 (+) CD45RA effector memory T cells, @entity804 expression on NK cells, @entity32882 (+) on @entity404 (+)T cells and BTLA4(+) on @entity404 (+)T central memory cells. Moderate CFS/ME @entity1 also had reduced @entity405 (+)T central memory @entity1454 , total @entity405 (+)T @entity16143 , na  ve @entity404 (+)T @entity16143 and @entity2940 (dim) @entity4071 (-) NK cell @entity3138 (+) and @entity1454 (+) @entity3138 (+). Severe CFS/ME @entity1 had increased @entity1454 (+) @entity2935 (-) in the @entity2940 (dim) @entity4071 (-) NK cell phenotype and reduced @entity3222 in @entity2940 (bright) @entity4071 (dim) NK cells. CONCLUSIONS: This research accentuated the presence of @entity1200 in CFS/ME and highlighted the importance of assessing functional parameters of both innate and adaptive immune systems in the illness.
