Near-infrared Fluorescence Optical Imaging in Early XXXX : A Comparison to Magnetic Resonance Imaging and Ultrasonography.

@entity1 @entity627 @entity603 @entity4668 @entity2720 @entity309
OBJECTIVE: Near-infrared fluorescence optical imaging (FOI) is a novel imaging technology in the detection and evaluation of different arthritides. FOI was validated in comparison to magnetic resonance imaging (MRI), greyscale ultrasonography (GSUS), and power Doppler ultrasonography (PDUS) in @entity1 with early @entity309 ( @entity309 ). METHODS: Hands of 31 @entity1 with early @entity309 were examined by FOI, MRI, and US. In each modality, @entity603 of the wrist, @entity2720 ( @entity2720 ) 2-5, and proximal interphalangeal joints (PIP) 2-5 were scored on a 4-point scale (0-3). Sensitivity and specificity of FOI were analyzed in comparison to MRI and US as reference methods, differentiating between 3 phases of FOI enhancement ( @entity4668 ). Intraclass correlation coefficients (ICC) were calculated to evaluate the agreement of FOI with MRI and US. RESULTS: A total of 279 joints (31 wrists, 124 @entity2720 and 124 @entity2720 ) were evaluated. With MRI as the reference method, overall sensitivity/specificity of FOI was 0.81/0.00, 0.49/0.84, and 0.86/0.38 for wrist, @entity2720 , and @entity2720 , respectively. Under application of PDUS as reference, sensitivity was even higher, while specificity turned out to be low, except for @entity2720 joints (0.88/0.15, 0.81/0.76, and 1.00/0.27, respectively). P2 appears to be the most sensitive FOI phase, while P1 showed the highest specificity. The best agreement of FOI was shown for PDUS, especially with @entity2720 (ICC of 0.57 and 0.53, respectively), while correlation with MRI was slightly lower. CONCLUSION: FOI remains an interesting diagnostic tool for @entity1 with early @entity309 , although this study revealed limitations concerning the detection of @entity603 . Further research is needed to evaluate its full diagnostic potential in @entity627 .
