Antidepressant-related XXXX : management via avoidance, switching antidepressants, antidotes, and adaptation.

@entity1 @entity323 @entity308 @entity935 @entity9021 @entity409 @entity13332 @entity458 @entity750 @entity752 @entity1063 @entity250
The ideal antidepressant would control @entity308 with no adverse effect on sexual function. @entity323 and other @entity250 associated with antidepressant medication treatment are problems with many antidepressants and can lead to @entity1 dissatisfaction and decreased compliance with treatment. A computerized MEDLINE search (English language, 1966-2003) was performed using the terms antidepressive agents, @entity323 , and @entity250 . Emphasis was placed on studies with specific sexual function measurements taken before and after treatment and placebo control. Mixed mediator, nonserotonergic antidepressants that block postsynaptic serotonin type 2 receptors ( @entity9021 , @entity13332 ) or that primarily increase @entity935 or @entity1063 levels ( @entity752 ) were thought to be good choices for avoiding antidepressant-associated @entity250 or for switching @entity1 in whom antidepressant-associated @entity250 emerged. Comparisons with @entity750 reuptake inhibitors (SRIs) have revealed @entity458 with nonserotonergic @entity752 , less @entity409 with @entity9021 , and superior overall satisfaction with sexual functioning with @entity752 or @entity9021 . However, most of these studies have design flaws that make evidence-based claims of efficacy difficult to substantiate. Agents proposed for antidote use in antidepressant-associated @entity250 have either not been studied in @entity1 or not proved efficacious in randomized placebo-controlled trials. Switching to and augmentation with @entity752 or @entity9021 have also not clearly shown efficacy in controlled trials and require care and monitoring to avoid SRI discontinuation symptoms and loss of antidepressant efficacy. Few proposed treatment options, apart from avoidance, have proved effective for antidepressant-associated @entity250 , which can have negative consequences on @entity308 management.
