XXXX , a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge.

@entity19 @entity14523 @entity526
UNASSIGNED: There is a growing consensus that long-term deficits in the brain are due to dynamic interactions between multiple neural and immune cell types. Specifically, radiation induces an inflammatory response, including changes in neuromodulatory pro- and anti-inflammatory cytokine secretion. The purpose of this study was to establish that there is sympathetic involvement in radiation-induced decrements early in in vivo immune function host defense. Female, 8-9 week-old C57BL/6J @entity19 were exposed to whole-body irradiation (WBI). There were 8 groups with radiation (0 vs. 3Gy protons), immune challenge ( @entity526 ) and exposure to the sympathetic ganglionic blocker, @entity14523 (1mg/kg weight, i.p.), as independent variables. Ten days post-irradiation, @entity19 were inoculated with @entity526 intraperitoneally and sacrificed 90-120min later. The data suggest that radiation-induced changes in immune function may in part be mediated by the sympathetic nervous system. Briefly, we found that radiation augments the bacteria-induced inflammatory cytokine response, particularly those cytokines involved in innate immunity. However, this augmentation can be reduced by the ganglionic blockade.
