CORRELATION OF INCREASED INTRAVITREOUS @entity13020 WITH XXXX IN PROLIFERATIVE DIABETIC RETINOPATHY.

@entity1 @entity2194 @entity6 @entity7 @entity2479 @entity13020 @entity1020
PURPOSE: To investigate @entity13020 and @entity7 ( @entity7 ) levels in the vitreous fluid of @entity1 with @entity6 ( @entity6 ) and to examine their correlation with @entity6 activity. METHODS: Vitreous samples from 45 eyes with @entity6 and 28 eyes with @entity1020 were collected. Active @entity6 was present in 24 @entity1 and inactive @entity6 in 21 @entity1 , according to @entity2479 . The @entity13020 and @entity7 level of vitreous fluid samples were measured by enzyme-linked immunosorbent assay. RESULTS: Comparison revealed that mean intravitreal levels of @entity13020 increased significantly in @entity2194 compared with control eyes (13.55 ng/mL vs. 1.57 ng/mL, P < 0.001). The mean @entity7 concentrations in the vitreous fluid of @entity1 with @entity6 were also higher than those in nondiabetic controls, with the values being 723.21 pg/mL and 20.81 pg/mL, respectively (P < 0.001). In addition, vitreous concentrations of @entity13020 and @entity7 were significantly higher in active @entity6 than in eyes with inactive @entity6 (P = 0.016 and P = 0.008, respectively). Furthermore, a significant positive correlation was detected between @entity13020 and @entity7 levels in the vitreous. CONCLUSION: Intravitreous levels of @entity13020 and @entity7 in @entity1 with @entity6 are increased and correlated mutually. @entity13020 may be an important player in the development of @entity6 and its activity in vitreous fluid can be biomarker of @entity6 .
