Changes of retina are not involved in the genesis of @entity1833 in XXXX .

@entity1833 @entity1 @entity29530 @entity191
@entity191 ( @entity191 ) is characterized by motor and nonmotor symptoms. Nonmotor symptoms include primarily @entity1833 ( @entity1833 ). The aim of our study was to establish whether @entity1 with @entity191 and @entity1833 ( @entity29530 +) have structural changes of retina detected by an optical coherence tomography (OCT) in comparison with @entity191 @entity1 without @entity1833 ( @entity29530 -). We examined 52 @entity191 @entity1 (18 with @entity1833 , 34 without @entity1833 ) and 15 age and sex matched healthy controls. Retinal nerve fiber layer (RNFL) thickness and macular thickness and volume were assessed by OCT. Functional impairment of retina was assessed using 2.5% contrast sensitivity test. For OCT outcomes we analyzed 15 @entity29530 + and 15 @entity29530 - subjects matched for age, gender, and @entity191 duration. For contrast sensitivity we analyzed 8 pairs of @entity1 matched for age, gender, and visual acuity. There was no significant difference in RNFL thickness and macular thickness and macular volume between 15 @entity29530 + and 15 @entity29530 - subjects, and also between a group of 44 @entity191 @entity1 (both @entity29530 + and @entity29530 -) and 15 age and gender matched healthy controls. No significant difference was found for 2.5% contrast sensitivity test values between @entity29530 + and @entity29530 - subjects. Therefore we conclude that functional and structural changes in retina play no role in genesis of @entity1833 in @entity191 .
