The response of isolated XXXX aorta to @entity11073 .

@entity859 @entity2515 @entity840 @entity14922 @entity11073 @entity5126 @entity3352 @entity1063
1. In helically cut strips of aorta from @entity2515 -treated @entity840 , cumulative concentrations (30 microM, 0.3 mM and 3 mM) of @entity11073 progressively reduced the basal tone of the preparations and relaxed the smooth muscle contracted by 1 microM @entity1063 or by 20 mM K+. 2. The relaxing effect was completely suppressed by tissue pretreatment with @entity859 deaminase (1 U ml-1). 3. Relaxation induced by @entity11073 was not affected by 50 microM @entity3352 or by 0.1 mM @entity14922 and was potentiated by 5 microM @entity5126 . 4. Like @entity11073 , exogenous @entity859 reduced the basal tone of the @entity840 aorta strips and relaxed the preparations contracted by 1 microM @entity1063 or by 20 mM k+ in a concentration-dependent manner. 5. The relaxing activity of exogenous @entity859 was not affected by 50 microM @entity3352 , was potentiated by 5 microM @entity5126 and was partially antagonized by 0.1 mM @entity14922 . 6. These results indicate the involvement of endogenous @entity859 in the relaxing effect of @entity11073 on @entity840 aorta strips, but the specific mechanism of @entity11073 - @entity859 interaction remains to be elucidated.
