Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin XXXX in C57BL/6 @entity19 .

@entity5212 @entity32 @entity9327 @entity19 @entity935 @entity26 @entity16 @entity191 @entity179 @entity27014 @entity4149 @entity15475
UNASSIGNED: Oxidative stress and @entity32 are some of the contributing factors for @entity179 in @entity191 ( @entity191 ). Though Valeriana wallichii D.C. is known for its nervine activities its effect against @entity191 is yet to be studied. This is the first report on the antioxidant and anti-inflammatory effect of V. wallichii rhizome extract (VWE) in @entity5212 induced @entity191 @entity19 . GC-MS analysis of VWE indicated the presence of phytoconstituents like @entity27014 and @entity15475 . @entity191 induced @entity19 were treated orally with three different doses (50, 100 and 200mg/kg body weight (BW)) of VWE for 14 days and their behavioural changes were studied on days 0, 8, 13 and 21. The levels of striatal @entity935 , mid brain @entity4149 hydroxylase positive (TH(+)) cell count, TH protein expression, reactive @entity26 species (ROS), lipid peroxidation (LPO), antioxidants and inflammatory cytokines were analysed. Mid brain @entity9327 ( @entity9327 ) expression was assessed by immunohistochemistry and western blotting. Also mid brain histopathological analysis was performed. VWE treatment significantly recuperated the altered behavioural test scores, striatal @entity935 levels, mid brain TH(+) cell count and TH protein levels, increased @entity9327 expression and the histopathological changes observed in @entity191 @entity19 . Similarly, diminished levels of antioxidants, elevated levels of ROS, LPO and inflammatory cytokines were also significantly ameliorated following VWE treatment. The effective dose of VWE was found to be 200mg/kg BW. Conclusively, V. wallichii rhizome extract has the potential to mitigate oxidative stress and @entity16 in @entity191 .
