Monthly rifampicin, ofloxacin, and minocycline therapy for generalized and localized XXXX annulare.

@entity1 @entity16395 @entity6 @entity738
BACKGROUND: The localized form of @entity738 annulare is usually self-limiting, resolving within 2 years. Generalized @entity738 annulare, on the other hand, runs a protracted course, with spontaneous resolution being rare. It is also characterized by a later age of onset, an increased incidence of @entity6 , poor response to therapy, and an increased prevalence of HLA @entity16395 . OBJECTIVE: To assess the efficacy of monthly pulsed rifampicin, ofloxacin, and minocycline (ROM) therapy in the management of @entity738 annulare. Methods : Six biopsy proven @entity1 of @entity738 annulare were included in the study, five of the generalized variety, and one localized. Three of these @entity1 were resistant to standard modalities of treatment. All six @entity1 were treated with pulses of once monthly ROM till complete resolution of all lesions. RESULTs were analyzed in terms of complete resolution of lesions and side effects. Presence of comorbid conditions was noted. RESULT: All six @entity1 were successfully treated with 4-8 pulses of monthly ROM. None of the @entity1 reported any adverse effects. LIMITATIONS: Small sample size and the lack of a control group are limitations. CONCLUSION: Treatment with pulses of once monthly ROM caused complete resolution of lesions in both localized and generalized @entity738 annulare, even in cases recalcitrant to conventional therapy. There were no side effects in any of the @entity1 . Larger trials are needed to substantiate the efficacy of monthly ROM in @entity738 annulare.
