Age at first XXXX and risk of recurrence: a prospective cohort study.

@entity1 @entity5 @entity1151 @entity1150 @entity4555 @entity1211
Risk of first @entity1211 ( @entity1211 ) increases with age. We investigated whether age is related to the risk of recurrent @entity1211 . We followed 694 @entity1 for a mean of 40 months after first unprovoked proximal @entity1150 ( @entity1150 ) and/or @entity1151 ( @entity1151 ) and withdrawal of anticoagulants. We excluded @entity1 with natural inhibitor deficiency, @entity4555 , or @entity5 ; @entity1 who required indefinite anticoagulation; pregnant @entity1 ; and @entity1 who had @entity1211 related to female hormone use. The endpoint was symptomatic recurrent @entity1211 . @entity1211 recurred in 152 @entity1 (22%). The adjusted hazard ratio (HR) of recurrence for a 10-year increase in age was 0.94 (95% confidence interval [CI], 0.82-1.08; p = 0.4). Compared with @entity1 aged younger than 47 years (1st tercile of @entity1 population) no significant increase in the risk of recurrent @entity1211 was found among @entity1 47-61 years old (2nd tercile) or @entity1 older than 61 years (3rd tercile) ([HR, 1.25; 95% CI, 0.78-2.01] and [HR, 0.93l; 95% CI, 0.56-1.53], respectively). Compared to @entity1 older than 80 years, the HR of recurrence among @entity1 younger than 50 years was 1.11 (95% CI, 0.11-10.3; p = 0.9). After 5 years, probability of recurrence was 32% (95% CI, 24%-40%) among @entity1 aged less than 47 years; 21% (95% CI, 15%-28%) among @entity1 47-61 years old; and 33% (95% CI, 24%-42%) among @entity1 older than 61 years (p = 0.5).Our results show that in @entity1 with first unprovoked proximal @entity1150 and/or @entity1151 , risk of recurrence is not related to age at first @entity1211 . Regardless of age, these @entity1 have a high risk of recurrence.
