Use of fast fourier transform analysis of atrial electrograms for rapid characterization of atrial activation-implications for delineating possible mechanisms of XXXX .

@entity712 @entity235 @entity2396 @entity591 @entity956 @entity955 @entity4710 @entity943
INTRODUCTION: Different analysis techniques have been developed to help understand and characterize the mechanisms responsible for @entity943 . We tested the hypothesis that Fast Fourier Transform (FFT) analysis of recorded atrial electrograms (AEGs) will rapidly and accurately identify regular and irregular patterns of atrial activation, and, thereby, may provide evidence suggestive of underlying mechanisms of @entity4710 . METHODS AND RESULTS: During induced @entity4710 in both the @entity235 sterile @entity2396 model and @entity235 rapid ventricular pacing-induced @entity712 model; 380-404 AEGs were recorded simultaneously from epicardial electrodes on both atria. From AEGs, atrial activation sequences were determined during @entity956 ( @entity956 ), focal @entity591 ( @entity591 ), and @entity955 ( @entity955 ). Four-second recording segments of each AEG were subjected to FFT analysis. Frequencies found during FFT analyses in all studies precisely corresponded to the cycle lengths of the AEGs. In @entity956 and @entity591 , one dominant frequency peak was found throughout both atria. In @entity955 due to multiple unstable reentry circuits, multiple and broad frequency peaks were found in both atria. In @entity955 due to a stable rapid rhythm (driver) in the left atrium with fibrillatory conduction to the rest of the atria, one dominant frequency peak in areas with 1:1 conduction from the driver, and multiple and/or broad frequency peaks in areas with fibrillatory conduction produced by the driver were found. Computation time for all FFT analyses took <5 minutes. CONCLUSION: FFT analysis accurately and rapidly identifies global atrial activation patterns during @entity956 , @entity591 , and @entity955 , thereby assisting in determining @entity943 mechanisms.
