[Differentiated XXXX : survival and prognostic factors].

@entity1 @entity9856 @entity8703 @entity5 @entity2802 @entity259 @entity204
BACKGROUND AND AIMS: Differentiated @entity259 (DTC) is the most common @entity8703 . @entity9856 has a good prognosis and survival rates higher than 85%. The aim of our study was to assess our current survival rate and to analyze prognostic factors. @entity1 AND METHODS: A retrospective analysis was conducted of 308 @entity1 with DTC (93.5% with @entity5 , 78.8% @entity1 ). Mean age at diagnosis was 45.4  15.8years, and mean follow-up time was 8.9  6.8years. The whole group was treated and followed up using the same protocol at our hospital. The following data were collected: age at diagnosis, sex, histology, @entity2802 stage, treatments, and date and cause of @entity204 . Survival probability was calculated using Kaplan-Meier analyses. Prognostic factors were analyzed using a univariate log rank test and a multivariate Cox regression analysis model. RESULTS: Twenty-six @entity1 died during follow-up, 15 of them (4.9%) from DTC. @entity259 -related survival was 92.7% for the whole group. In multivariate analyses, the following parameters were associated to a significantly increased risk of @entity204 from DTC: presence of distant metastases, follicular histology, age at diagnosis older than 60years, and extrathyroid invasion. DISCUSSION: Our survival rate is similar to that reported in literature. Assessment of prognostic factors related to an increased risk of @entity204 in our @entity1 group, is essential to establish active therapeutic approaches in high risk @entity1 .
