Heat stress-induced hepatotoxicity and its prevention by @entity4025 in XXXX .

@entity3978 @entity99 @entity66 @entity39 @entity221 @entity409 @entity2041 @entity8291 @entity492 @entity12609 @entity35 @entity4025 @entity224 @entity493
The high ambient temperature beyond the range of comfort zone or thermoneutral zone causes environmental @entity8291 ( @entity8291 ). It causes serious physiological dysfunction that may result in @entity66 and even death. The underlying mechanism in the pathogenesis of @entity409 following hyperthermic challenge and the possible involvement of oxidative stress to induce oxidative deterioration of liver functions in adult @entity35 are investigated in this study. Cellular damage was assessed in terms of serum @entity493 aminotransferase (ALT) and @entity492 aminotransferase (AST) activities and histology of liver. The effect of @entity221 in altering the oxidative stress was evaluated on the basis of its influence on hepatic lipid peroxidation and antioxidant status- @entity224 dismutase (SOD), @entity12609 ( @entity12609 ) and @entity2041 peroxidase (GPx) activity. The current study demonstrated that @entity8291 is associated with a complex set of integrated alterations in liver, time-dependent rise in oxidative stress followed by distinct pattern of @entity99 in animals. Heat-induced hepatotoxicity was assessed by increased lipid peroxidation, depletion of antioxidant enzyme activities such as SOD, @entity12609 , GPx and tissue damages revealed by hepatic vacuolization, and widespread @entity39 . The study also revealed that pretreatment with @entity4025 resulted in normalizing these parameters appreciably, emphasizing the therapeutic potentials of this @entity3978 . Taken together, the results suggest that an increase in free radical formation relative to loss of the antioxidant defense system during @entity8291 may render liver more susceptible to oxidative damage, leading to their functional inactivation. However, @entity4025 supplementation can be an effective antidote in the treatment of @entity8291 -induced malfunction.
