XXXX gene mutations are not involved in @entity2946 in @entity1 .

@entity1 @entity6196 @entity706 @entity1313 @entity5 @entity16 @entity1221 @entity14050 @entity70911 @entity816 @entity70910 @entity1129 @entity2946
@entity6196 ( @entity6196 )- @entity2946 account for approximately 20% of all @entity1313 in @entity1 . @entity1129 is an @entity16 with predisposition to @entity5 . The most common @entity5 are @entity706 and @entity5 , including @entity1221 , @entity816 , and @entity2946 . To investigate the potential role of the @entity14050 gene in the pathogenesis of @entity2946 , 13 @entity5 were screened for @entity14050 mutations and 9 for loss of heterozygosity (LOH) of the @entity14050 locus and flanking regions. In none of the @entity5 were mutations identified. In five of them, the well-known polymorphisms @entity70910 and @entity70911 were identified and in all 22 @entity5 , the wild-type allele was preserved. The frequency of the polymorphisms was similar to that reported in our and other normal populations. The LOH of the 11q region (including the @entity14050 gene), detected in 25% of informative cases, is consistent with the molecular and cytogenetic reports of deletion of chromosome 11 in 13%-41% of @entity2946 . These results indicate that mutations in the @entity14050 gene do not play a role in the pathogenesis of @entity2946 in @entity1 . The LOH in the 11q region may suggest hidden unidentified @entity5 suppressor genes that may be involved in the malignant transformation.
