XXXX and cytosolic phospholipase A2a form a positive loop in @entity263 cells.

@entity263 @entity22704 @entity19 @entity1426 @entity2370 @entity1994 @entity4357
UNASSIGNED: Aberrant increase in protein kinase B ( @entity1994 ) phosphorylation (pAKT), due to a gain-of-function mutation of @entity4357 -3-kinase (PI3K) or loss-of-function mutation or deletion of phosphatase and tensin homolog ( @entity2370 ), is a common alteration in @entity263 and associated with poor prognosis. Cytosolic phospholipase A2a ( @entity22704 ) is a lipid modifying enzyme by catalyzing the hydrolysis of @entity1426 from membrane phospholipid. The released @entity1426 and its metabolites contribute to survival and proliferation of @entity263 cells. In this mini-review, we summarize the relationship between pAKT and @entity22704 in @entity263 cells. There was a concordant increase in pAKT and @entity22704 levels in prostate tissue of prostate epithelial-specific @entity2370 -knockout @entity19 compared to @entity2370 -wild type @entity19 . Restoration of @entity2370 expression or inhibition of PI3K action decreased @entity22704 expression in @entity2370 -mutated or deleted @entity263 cells. An increase in @entity1994 phosphorylation elevated, whereas inhibition of @entity1994 phosphorylation diminished, @entity22704 protein levels. pAKT had no influence on @entity22704 a expression at mRNA levels but stabilized @entity22704 at protein levels by protecting it from degradation. Conversely, an induction of @entity22704 expression led to an increase in pAKT levels in @entity2370 -mutated or deleted @entity263 cells, while silencing of @entity22704 expression or pharmacological blocking @entity22704 a action decreased pAKT levels. The diminishment of pAKT by either genetic silencing or pharmacological blocking of @entity22704 was mitigated by the addition of @entity1426 . The stimulatory effect of @entity1426 on pAKT levels was lessened by inhibiting the production of @entity1426 metabolites. These studies have revealed a link between oncogenic pathway and lipid metabolism and provided potential molecular targets for treating @entity263 .
