Prognostic factors in high-grade XXXX . A multivariate analysis of 76 cases with postoperative radiotherapy.

@entity1 @entity5 @entity11 @entity816 @entity463
PURPOSE: @entity1 with @entity11 have a limited survival prognosis. We retrospectively analyzed data of @entity11 @entity1 with the aim of defining prognostic factors on which individualized treatment strategies might be built on. @entity1 AND METHODS: Seventy-six @entity1 with primary @entity11 (51 @entity463 multiforme, 20 @entity816 , 4 anaplastic oligo- @entity816 , 1 @entity11 ) were postoperatively irradiated with 5 and 8 Me V photons, 2 Gy per fraction to a median total dose of 60 Gy (range 50 to 70 Gy). RESULTS: The youngest quartile of @entity1 (up to 45 years) had the highest 3-year survival rates (mean +/- SE: 15 +/- 8%) and median survival time (17.9 months, 95% confidence interval: 9.2, 24.2 months) as compared to the oldest quartile (> 61 years) with no 3-year survivor and a median survival time of 9.7 months (7.2, 12.3 months). The middle quartiles (46 to 61 years) showed intermediate results. The difference between the youngest and oldest quartile (p = 0.01) and the middle quartile versus the oldest quartile (p = 0.04) was significant. In univariate analysis, @entity5 size (p = 0.04 for -30 mm vs > 50 mm) was of importance. In multivariate analysis only age of the @entity1 reached statistical significance (p = 0.03). As compared to the youngest quartile of @entity1 , the oldest quartile had a relative risk of 2.1 (95% confidence interval: 0.9, 5.1) of dying from the disease; the age group of 46 to 61 years had a relative risk of 2.0 (0.9, 4.3). CONCLUSIONS: Age of the @entity1 is the most important factor for survival prognosis favouring younger age (< or = 45 years). The possible implications for radiation therapy are discussed.
