Immunoreactivity against tau, XXXX , and beta-amyloid in the @entity1 retina.

@entity1 @entity2000 @entity989 @entity6391 @entity477 @entity179 @entity195 @entity1020
PURPOSE: Increased immunoreactivity (IR) of beta-amyloid and the amyloid-associated proteins tau and @entity477 ( @entity477 ) in the brain have been linked to the pathogenesis of @entity179 such as @entity195 . However, the expression of these proteins has not been investigated in the normal or diseased @entity1 retina. METHODS: Using immunohistochemical techniques, we examined the distribution and age-related changes of anti-tau-1, anti-tau-2, anti- @entity477 , and anti-beta-amyloid IR in the @entity1 retina at various ages (n = 24), in @entity6391 ( @entity6391 , n = 6), and in @entity1020 ( @entity1020 , n = 10). RESULTS: Tau-1 immunoreactivity was intense in the inner retinal layers and did not change with age or in @entity6391 . Eyes with @entity1020 showed less intense staining but exhibited a similar distribution. Tau-2 IR was faint and did not change with age but was mildly increased in the @entity989 ( @entity989 ) of eyes with @entity6391 with @entity1020 . @entity477 IR was most prominent in the ganglion cell and nerve fiber layer, and it appeared to increase in ganglion cells of older @entity1 and in @entity989 cells of eyes with @entity6391 and @entity1020 . Beta-amyloid IR was only detected focally in sub- @entity989 deposits in eyes from older @entity1 . CONCLUSIONS: The proteins investigated in this study are present in the @entity1 retina. The staining pattern of tau is different from the brain, but it shows no age-related changes. The increased immunoreactivity of @entity477 in @entity989 and in @entity989 cells of eyes with @entity6391 and @entity1020 , as well as the patchy staining of beta-amyloid within sub- @entity989 deposits, might indicate a relationship of these proteins to retinal aging and possibly to @entity2000 in @entity6391 .
