Sonographic maturation of the placenta at 30 to 34 weeks is not associated with second trimester markers of XXXX in low-risk pregnancies.

@entity1 @entity548 @entity5028 @entity600 @entity1592 @entity1468 @entity7310 @entity2431
OBJECTIVE: Advanced placental maturation (Grannum [G] grade 3) before term is associated with adverse perinatal outcomes associated with @entity2431 . The nature and timing of the underlying pathology of this process is presently unclear. We hypothesized that advanced placental maturation at 30 to 34 weeks' gestation is not associated with established second trimester markers of severe @entity5028 . METHODS: In a cohort study of 1238 low-risk Caucasian @entity1 with singleton pregnancies who had sonographic assessment of placental maturation and fetal growth at 34 weeks, the results of @entity7310 ( @entity7310 ) and uterine artery Doppler (UtAD) flow studies at 16 weeks were related to adverse perinatal outcomes associated with @entity2431 : antepartum @entity548 , @entity1468 , @entity600 < 37 weeks, small for gestational age (< 10th percentile), or postnatal evidence of @entity1592 ( @entity1592 ; ponderal index < 5th percentile). RESULTS: G1 was found in 127 @entity1 (10.3%), G2 was found in 18 @entity1 (1.5%), and no cases of G3 were observed. Advanced Grannum grading was significantly associated with @entity1592 (48 [4.4%] in G0, 9 [7.1%] in G1, 5 [27.8%] in G2; P < 0.001), but was dependent on smoking status. @entity1592 was not predicted by abnormal @entity7310 or abnormal UtAD findings at either the second or third trimester ultrasounds. CONCLUSION: G2 maturation at 30 to 34 weeks' gestation is associated with mild @entity1592 at delivery in low-risk @entity1 and with smoking. @entity1592 was not predicted by either second or third trimester markers of severe @entity5028 . Future studies directly observing the placenta in the late third trimester may aid the elusive diagnosis of "late-onset" mild @entity1592 .
