Participation, yield, and interval carcinomas in three rounds of biennial FIT-based XXXX screening.

@entity5 @entity1 @entity14
BACKGROUND: The effectiveness of @entity14 screening programs based on the fecal immunochemical test (FIT) is influenced by program adherence during consecutive screening rounds. We aimed to evaluate the participation rate, yield, and @entity5 in a third round of biennial @entity14 screening using FIT and to compare those with the first and the second screening round. METHODS: A total of 3566 average-risk individuals aged 50-75 years were invited to participate in a third round of biennial FIT-based @entity14 screening. All FIT positives were recommended to undergo colonoscopy. We merged our data with the national @entity5 registry in the Netherlands to identify all non-screen-detected @entity5 in our cohort. RESULTS: Of the invitees, 2142 (60%) returned the FIT in this third screening round, compared to 56% in the second round and 57% in the first round. Overall, 153 of the third-round @entity1 (7.1%) had a positive FIT result, versus 7.9% in the second round and 8.1% in the first round (P=0.05). Of all FIT positives, 123 (80%) underwent colonoscopy. Within this group, 33 @entity1 had advanced @entity5 . The predictive value of FIT positivity for advanced @entity5 was 27% (33/123), compared to 42% in the second round and 54% in the first round - a significant decline (P<0.01). CONCLUSION: In an FIT-based screening program, participation rates remained stable over consecutive biennial screening rounds, while the FIT positivity rate and positive predictive value for advanced @entity5 gradually declined. @entity5 in non- @entity1 are significantly more advanced in staging than @entity5 in @entity1 in the first round of screening.
