XXXX -Based Chemotherapy for Testicular Germ Cell Tumors: Complication Rates of Peripheral versus Central Venous Administration.

@entity1 @entity137 @entity900 @entity532 @entity2969 @entity1211
OBJECTIVE: Despite the low local @entity137 of the used agents, @entity900 -based chemotherapy (CBP) for @entity1 with @entity2969 ( @entity2969 ) is mostly delivered via a @entity1211 ( @entity1211 ). Since 2008, CBP is given peripherally in our hospital. METHODS: Medical reports of @entity2969 @entity1 who received CBP between September 1991 and August 2014 were evaluated. Complications regarding the way of administration ( @entity1211 vs. peripheral venous catheter [PVC]) were classified according to the Common Terminology Criteria of Adverse Events. The complication rates were compared using chi square test and propensity score matching. RESULTS: During 288 cycles in 109 @entity1 , 85 complications (29.5%) were observed with similar rates for overall (PVC 31.3%, @entity1211 29.9%; p = 0.820) and grade I complications (21.3%, 25.4%; p = 0.470). More grade II complications were observed in the PVC group (10.0 vs. 1.5%; p < 0.001). @entity532 requiring invasive treatment were found only in the @entity1211 group (3.0%; p = 0.120). Using propensity score matching, no differences in overall (p = 0.950), grade I (p = 0.540) and grades II/III (p = 0.590) complications were seen. CONCLUSION: The peripheral and central administration of CBP has similar overall complication rates. Despite more grade II complications, the peripheral administration of CBP is a safe alternative for @entity2969 @entity1 . Additionally, no severe @entity532 occurred.
