Epidemiological and histopathological data and XXXX -like prognostic factors in early carcinomas of the tongue and floor of mouth.

@entity1 @entity13389 @entity167 @entity5 @entity957 @entity5962
Despite recent advances in diagnosis and treatment, overall survival of @entity1 with @entity957 floor continues to be low. Prognostic information is essential for improved evaluation and treatment. A molecular approach is necessary for a better understanding of @entity5 . We analyzed 50 @entity1 with early @entity957 (stages I and II - AJCC, 1997), who were surgically treated in head and neck departments at Heliopolis Hospital and Santa @entity13389 in S  o Paulo, Brazil. We searched for epidemiological and pathological behaviors that could be involved in @entity5 recurrence and the influence of cellular adhesion loss in @entity1 outcome. We established two groups: @entity1 with disease recurrence within 3 years of follow-up and @entity1 with no @entity5 recurrence in this period. Significant prognostic variables included age, daily @entity167 intake, neural invasion and maximum @entity5 thickness. Our findings are similar to other published data in which younger @entity1 have a better prognosis. The odds ratio for neural invasion was low but was significant for thickness. No significant difference was observed among groups in @entity5962 expression. Our data suggest that 3 and 5mm are the prognostic determinants of thickness. @entity5962 mutation was not related to recurrences but was associated with locally aggressive invasion patterns.
