Long-term outcomes after treatment for pedunculated-type T1 XXXX : a multicenter retrospective cohort study.

@entity1 @entity1600 @entity189 @entity14 @entity3 @entity694
BACKGROUND: The risk for @entity1600 and the prognostic significance of pedunculated-type T1 @entity14 ( @entity189 ) require further study. We aimed to assess the validity of the 2014 Japanese Society for @entity694 (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1 @entity189 . METHODS: In this multicenter retrospective cohort study, we examined 176 @entity1 who underwent resection endoscopically or surgically at 14 institutions between January 1990 and December 2010. @entity1 meeting the JSCCR curative criteria were defined as "endoscopically curable (e-curable)" and those who did not were "non-e-curable". We evaluated the prognosis of 116 @entity1 (58 e-curable, 58 non-e-curable) who were observed for  >5  years after treatment. RESULTS: Overall incidence of @entity1600 was 5  % (4/81; 95  % confidence interval 1.4-12  %: three cases of submucosal invasion depth  >= 1000   m [stalk invasion] and lymphatic invasion, one case of head invasion and budding grade 2/3). There was no local or metastatic recurrence in the e-curable @entity1 , but six of them died of another cause (observation period, 80  months). There was no local recurrence in the non-e-curable @entity1 ; however, distant @entity3 was observed in one @entity1 . Death due to the primary disease was not observed in non-e-curable @entity1 , but six of them died of another cause (observation period, 72  months). CONCLUSIONS: Our data support the validity of the JSCCR curative criteria for pedunculated-type T1 @entity189 . Endoscopic resection cannot be considered curative for pedunculated-type T1 CRC with head invasion alone.
