@entity412 , but not total @entity165 or low-density lipoprotein @entity165 levels, predict development of XXXX .

@entity1 @entity644 @entity8 @entity2299 @entity1674 @entity412 @entity165
BACKGROUND: Epidemiological data about the relationship between @entity2299 and @entity644 are sparse. We conducted a retrospective and longitudinal study in a large screened cohort to evaluate whether @entity412 , high-density lipoprotein (HDL) @entity165 , total @entity165 , and low-density lipoprotein (LDL) @entity165 levels increase the risk of development of @entity644 and loss of renal function. METHODS: Post hoc analysis was performed for 4326 subjects who were free from @entity644 (dipstick 1+ or higher) at baseline (1997) with a follow-up period through 2000. Outcome measures were the development of @entity644 (1+ or higher) and change in glomerular filtration rate (GFR). Multiple logistic analysis and multiple regression analysis were used to analyze baseline characteristics related to the outcome measures. RESULTS: During the observational period, 505 (11.7%) of subjects had one or more episodes of @entity644 (>/=1+). Adjusted relative risk of @entity1674 for one or more incidences of @entity644 was 1.007 (95% CI 1.000 to 1.105, P = 0.04) in @entity1 and 1.032 (95% CI 1.004 to 1.061, P = 0.02) in @entity1 . Total @entity165 , HDL @entity165 , and LDL @entity165 were not significant predictors of @entity644 . The mean change in GFR between 1997 and 2000 was -6.3 (SD = 9.0) mL/min/1.73 m2 in @entity1 , and -7.8 (SD = 10.7) mL/min/1.73 m2 in @entity1 . HDL @entity165 (beta = 0.04, t = 3.7, P = 0.0002) in @entity1 and @entity1674 (per 10 mg/dL, beta = -0.09, t = -2.2, P = 0.02) in @entity1 were correlated with the change in GFR. CONCLUSIONS: High @entity412 levels predicted a risk of developing @entity644 in both @entity1 and @entity1 , but not total @entity165 nor LDL @entity165 . High @entity412 in @entity1 and low HDL @entity165 in @entity1 predicted the decline of renal function. It remains to be determined whether prospective treatment of @entity2299 will protect against @entity8 .
