Genetic and environmental influences on XXXX in an Australian twin sample.

@entity308 @entity1109 @entity74 @entity158 @entity663 @entity3010
BACKGROUND: We aimed to explore the prevalence and factor structure of @entity1109 in a sample of Australian twins; to investigate phenotypic associations between reported @entity1109 , personality and reproductive dimensions; and to identify the relative contributions of genes and environment to @entity1109 and the extent of genetic and environmental covariation with the personality trait Neuroticism and lifetime major @entity308 . METHOD: Seven hundred and twenty female twin pairs (454 monozygotic and 266 dizygotic) from the Australian National Health and Medical Research Council Twin Register reported on experience of 17 @entity1109 during the previous 12 months. In the same questionnaire twins also responded to questions on symptom states, and personality dimensions including @entity663 . Interview data enabling diagnosis of lifetime history of DSM-IV major @entity308 were also available. We fitted univariate and multivariate genetic models to the data. RESULTS: Most frequently reported symptoms were breast tenderness/ @entity158 and bloating/weight gain, followed by affective symptoms. Twelve-month prevalence was 24% for the combination of symptoms and functional interference meeting a very rough approximation of DSM-III-R criteria for late @entity74 . Principal factor analysis identified a single @entity3010 ( @entity3010 ) factor. @entity74 (44% of total variance) were identified for @entity3010 . Although we found genetic correlations of 0.62 between reported @entity3010 and @entity663 , and 0 70 with lifetime major @entity308 , 39 % of the genetic variance of @entity3010 was not explained by these factors. CONCLUSIONS: Our findings support the existence of genetic influences on @entity1109 , but we were unable to distinguish between liability to symptom experience and symptom reporting. Retrospective reporting may have contributed to our finding that @entity3010 genes were shared in part with @entity663 and liability to lifetime major @entity308 .
