Simultaneous presentation of XXXX involving the ovary and the uterine corpus.

@entity1 @entity43 @entity5 @entity189 @entity3 @entity4348
Twenty-nine @entity1 had simultaneous @entity5 of the uterine corpus and ovary. Three groups were defined on the basis of @entity5 histology: Group A: those with @entity4348 in both the uterus and ovary; Group B: those with special variants of @entity189 (papillary, clear cell, mucinous) and identical @entity5 in the ovary; and Group C: those whose uterine and @entity43 were of dissimilar histologic types. Sixteen @entity1 had @entity4348 in both sites. The median age at diagnosis, 41 years, was younger than is usual for @entity43 . For all 16 @entity1 , the grade of the @entity43 was similar to that of the @entity4348 of the uterine corpus. Seven @entity1 had bilateral @entity43 . Only one @entity1 had myometrial invasion by the @entity189 . No @entity1 with simultaneous ovarian and uterine @entity4348 , regardless of grade, has died of @entity5 although one vaginal relapse was treated successfully. This excellent survival of @entity1 with simultaneous @entity4348 is better than would be expected for either @entity5 of the endometrium or @entity43 . These simultaneously occurring endometrioid @entity5 of ovary and endometrium are considered to be separate @entity5 . The morphologic reasons for this view and therapeutic implications are discussed. In contrast to the @entity1 with @entity4348 , the eleven @entity1 with other histologic types of @entity189 in the ovary and corpus were older (median age, 61 years) and more often postmenopausal (90%). These @entity5 were more aggressive, with frequent deep myometrial involvement (63%), tubal involvement (27%), and extension to other pelvic tissues (36%) at the time of initial diagnosis. Six of these 11 @entity1 succumbed to their @entity5 despite surgical therapy and radiation. The distribution of @entity5 in some of these @entity1 with nonendometrioid types of @entity189 is suggestive of a single primary with @entity3 . The therapeutic implications of these findings are discussed.
