@entity0 in a prospective cohort of overweight and @entity28 US XXXX .

@entity1 @entity353 @entity0 @entity28 @entity5
Overweight and @entity28 are associated with increased @entity0 risk; however, it is unclear whether losing excess weight will lower risk. Therefore, we examined the relationship between @entity0 among 13,055 overweight and @entity28 , @entity5 -free @entity1 who enrolled in the @entity5 Prevention Study-II (CPS-II) Nutrition Cohort in 1992. During the 15 year follow-up, 816 @entity0 cases were diagnosed. Self-reported weight was collected before diagnosis at baseline and 10 years prior to baseline. The median @entity353 was 11 lbs, but only 58% of the @entity1 maintained this @entity353 through the first 5 year follow-up interval (1992-1997). Using both restricted cubic splines and multivariate Cox proportional hazards modeling, we observed no association between @entity0 . The hazard ratio for 30+ pounds of @entity353 compared to stable weight was 0.95 (95%: CI 0.47-1.95). An inverse association was, however, suggested among @entity1 who maintained ten or more pounds of @entity353 through the next interval. There was no evidence of effect modification by postmenopausal hormone use, initial BMI, or other factors examined. In summary, @entity353 was not associated with @entity0 in this study. Future studies should focus on sustained @entity353 and whether the timing of @entity353 is important.
