Oxidized low-density lipoprotein and beta2-glycoprotein I in @entity1 with XXXX and increased carotid @entity121 : implications in autoimmune-mediated @entity731 .

@entity1 @entity731 @entity9500 @entity1252 @entity1701 @entity715 @entity121 @entity65
Oxidative stress and LDL modification (oxLDL) are early pro-atherogenic events. OxLDL binds @entity9500 producing immunogenic oxLDL/ @entity9500 complexes. Antibodies to these complexes have been associated with arterial @entity715 in @entity1 with @entity1252 ( @entity1252 ) and @entity1701 ( @entity1701 ). Circulating oxLDL/ @entity9500 complexes, IgG and IgM antibodies to these complexes were measured by ELISA in 30 @entity1252 @entity1 asymptomatic for @entity65 (mean age 31 years) and 27 age/sex matched healthy controls. Carotid @entity121 ( @entity121 ) was measured by ultrasound in all @entity1 and controls. Forty-seven percent of @entity1252 presented plaques (median @entity121 of 0.65 +/- 0.12 mm) while only 7% of the controls had plaques (median @entity121 of 0.50 +/- 0.04 mm, P < 0.001). Median optical density (OD450nm) for oxLDL/ @entity9500 complexes in @entity1252 was 0.244 +/- 0.07, higher than controls (0.174 +/- 0.09, P < 0.001). Median OD for IgG anti-oxLDL/ @entity9500 antibodies was also higher in @entity1252 (0.297 +/- 0.26) compared to controls (0.194 +/- 0.07, P < 0.001) while the median OD for IgM antibodies in @entity1252 (0.444 +/- 0.46) was not different than controls (0.326 +/- 0.22, P = 0.267). There was no correlation between @entity121 and oxLDL/ @entity9500 complexes, IgG or IgM antibodies, possibly reflecting the complex interrelationship between these serologic elements and tissue factors in the arterial wall. These results support the hypothesis that oxLDL/ @entity9500 complexes and IgG (not IgM) anti-oxLDL/ @entity9500 antibodies contribute to the development of autoimmune-mediated @entity731 .
