Gene expression of the IGF binding proteins during post-implantation embryogenesis of the XXXX ; comparison with the expression of IGF-I and -II and their receptors in rodent and @entity1 .

@entity38878 @entity1 @entity19 @entity36628 @entity71370 @entity10251 @entity10511 @entity10248 @entity10509 @entity10250
The IGF binding proteins (IGFBPs) comprise at least six distinct species which may modulate the action of IGFs. IGFs are important regulators of fetal growth and differentiation. We have studied the mRNA expression of the six IGFBPs during post-implantation embryogenesis (day 11-18) by in situ hybridization techniques. Expression of @entity36628 was detected in @entity19 conceptuses after day 12 of gestation and seemed restricted to the liver. Transcripts for @entity10509 were detected in various tissues and were found in all stages tested. In contrast, expression of @entity71370 could be detected only weakly in late gestational embryos. Comparison of the expression pattern of @entity10509 , which were found widely distributed in @entity19 conceptuses, revealed that @entity10248 was expressed mainly in the ectodermal layer and also in the mesoderm derived part of the tongue (day 13.5). Transcripts for @entity10250 however, only were detected in the mesoderm derived tissues, whereas expression of @entity10251 was restricted to the ectodermal layer. A similar distribution pattern was observed in the lung. In general, expression of @entity38878 was detected in the same cells, whereas @entity10511 were expressed mainly in different cell types. In rodents as in the @entity1 there is widespread expression of the genes coding IGFs, the IGFBPs and the receptors during pre- and postimplantation embryogenesis. These data support the assumption that the IGFs play an important role during embryogenesis.
