Four-Year Changes in Visceral Fat Mass and the Risk of Developing XXXX in the General Population.

@entity1 @entity644 @entity1144 @entity1011 @entity1386
BACKGROUND: Previous cross-sectional studies demonstrated the close relationship between @entity1144 and the increased prevalence of @entity644 . But, little is known about the role of changes in @entity1386 (   @entity1386 ) over several years in the development of @entity644 . In this longitudinal cohort study with the general population, the changes in    @entity1386 as well as baseline @entity1386 on @entity644 development were evaluated. METHODS: Healthy individuals (n = 2393) who participated in two health screening exams were analyzed. Subjects were divided into three groups based on gender-specific tertiles of baseline @entity1386 and    @entity1386 . Each @entity1 was tested for @entity644 using a dipstick, and @entity644 was defined as 1+ or greater. RESULTS: The mean age was 51.9  7.7 years, and the incidence of @entity644 was 3.9% (n = 93). During the 4 years, 52.5% of the subjects experienced a decline in    @entity1386 . However, subjects who developed @entity644 exhibited a significant increase in    @entity1386 . Even after adjustment for age, smoking, systolic and diastolic BP, serum @entity1011 , and hs-CRP levels, the highest tertiles for baseline @entity1386 [ @entity1 , odds ratio (OR) 3.43, 95% confidence interval (CI) 1.22-9.67; @entity1 , OR 2.01, 95% CI 1.05-4.15] and    @entity1386 ( @entity1 , OR 2.92, 95% CI 1.22-6.99; @entity1 , OR 3.16, 95% CI 1.56-6.39) were independent predictors of @entity644 development. Following adjustment of both parameters, subjects in the highest baseline @entity1386 and    @entity1386 tertiles exhibited the greatest risk of @entity644 development, which suggested the additive harmful effects of the two factors. CONCLUSIONS: Baseline @entity1386 and greater increase in    @entity1386 were both important risk factors for developing @entity644 in the general population. Appropriate education and interventions to prevent accumulation of @entity1386 should be the major focus of preemptive strategies.
