[Effect of perfluorochemicals on @entity3600 chemotherapy in a @entity35 XXXX model].

@entity1313 @entity39 @entity5 @entity26 @entity11 @entity3600 @entity519 @entity544 @entity27533 @entity35
Perfluorochemicals ( @entity27533 -43) is characterized with its small size and high propensity for carrying @entity26 and @entity544 , and also have the function to improve the cerebral microcirculation. These characteristic features of @entity27533 -43 may have a beneficial effect on @entity1313 chemotherapy in terms of the oxygenation of @entity519 cells, and/or the improvement of the pharmacokinetics of anticancer drugs. This study was undertaken to identify the combined effect of perfluorochemicals ( @entity27533 -43, 20 ml/kg) and chemotherapeutic agent ( @entity3600 , LD10 dose; 13.3 mg/kg) in a @entity35 @entity1313 model. @entity1313 model was made by the intracerebral implantation of C6 @entity35 @entity11 cells (1 X 10(5) cells/10 microliters). At 10 days after implantation, control animals had a macrotumor weighing about 100 mg with large part of central @entity39 . The @entity5 -bearing @entity35 for 10 days after implantation were randomly divided into 4 groups; a control group, a @entity27533 -43 treatment group, a @entity3600 treatment group, and a @entity27533 -43 plus @entity3600 treatment group. Control animals had mean survival time of 19.94 +/- 2.41 (S.D.) days, and mean survival time of @entity27533 -43 treatment group was 19.47 +/- 1.36 days. @entity3600 treatment alone prolonged the mean survival time to 28.36 +/- 7.94 days (p less than 0.001). @entity27533 -43 plus @entity3600 treatment group showed 36.00 +/- 10.15 days, which was significantly greater than that of @entity3600 treatment alone group (p less than 0.005). The long survivals lived over 50 days after implantation were 7 out of 27 @entity35 in @entity27533 -43 plus @entity3600 treatment group, in contrast to one out of 25 @entity35 in @entity3600 treatment alone group. Perfluorochemicals ( @entity27533 -43) may have the synergistic effect on @entity3600 chemotherapy for @entity1313 . It was speculated for the above results that following the oxygenation of @entity519 cells by @entity27533 -43, @entity519 cells might be sensitized to @entity3600 , which might be much delivered into @entity519 area. And further studies should be done for the evaluation of the mechanism of perfluorochemicals on @entity1313 experimentally before clinical application.
