Association of HLA-DR/DQ Alleles and Haplotypes with XXXX .

@entity1 @entity3098 @entity2149 @entity1985 @entity1533 @entity479
BACKGROUND: @entity1985 ( @entity1985 ) is a debilitating renal problem in @entity1 resulting from an interaction between environmental and genetic factors including human leukocyte antigen genes (HLA). The aim of this work was to study the probable link between HLA alleles/haplotypes and @entity1985 in south India. METHODS: @entity1533 */ @entity3098 * alleles were genotyped in 183 @entity1985 (76 @entity479 sensitive-SSNS; 107 @entity479 resistant-SRNS) and pediatric healthy controls (PHCs; n, 91) using polymerase chain reaction-sequence specific primers (PCR-SSP). -A/-B genotyping was performed for @entity1 (n, 70) positive for @entity1533 *07- @entity3098 *02 haplotype to identify four locus extended haplotype. RESULTS: The following alleles and haplotypes were strongly associated with @entity1985 (p   <   0.05 as significant): @entity1533 *07 (SSNS, p   <   7.98   *   10(-6) ; SRNS, p   <   0.008), @entity3098 *02 (SSNS, p   <   3.99   *   10(-6) ; SRNS, p   <   0.002), @entity1533 *07- @entity3098 *02 (SSNS, p   <   1.32   *   10(-4) ; SRNS, p   <   0.010), @entity1533 *07- @entity3098 *03 (SSNS, p   <   0.001) and @entity1533 *03- @entity3098 *02 (SRNS, p   <   0.048). Protective associations were observed for alleles @entity1533 *10 (SRNS, p   <   0.013), @entity3098 *05 (SSNS, p   <   4.34   *   10(-6) ; SRNS, p   <   0.01), @entity3098 *06 (SSNS, p   <   0.003), and haplotypes @entity1533 *10- @entity3098 *06 (SSNS, p   <   0.046; SRNS, p   <   0.032) and @entity1533 *15- @entity3098 *05 (SSNS, p   <   0.018). @entity2149 typing of 70 @entity1985 cases with two locus haplotype @entity1533 *07- @entity3098 *02 (70/183; 38.25%) revealed the presence of an extended haplotype 'A*03-B*07- @entity1533 *07- @entity3098 *02' (n,35; 50%). CONCLUSION: Our study revealed strong susceptible association of @entity1533 *07 with SRNS and @entity3098 *02 with SSNS. A gender predominant protective association was observed for @entity1533 *10 with SRNS females; @entity3098 *05 with SSNS and SRNS males. Further, the study documented the presence of an extended haplotype and pleiotropic action of @entity1533 */ @entity3098 * alleles in immune-mediated etiology of @entity1985 in south India. This article is protected by copyright. All rights reserved.
