Chemically induced @entity2553 : the effect of XXXX , @entity432 , and adrenergic blockade.

@entity5733 @entity63 @entity432 @entity35 @entity2553 @entity1063
@entity2553 in revascularized tissue can compromise tissue perfusion even though the microsurgical anastomoses remain patent. Circulating @entity5733 stimulates peripheral vasoconstriction. Chemical @entity2553 was induced by the intraarterial administration of @entity1063 to denervated @entity35 hind limbs. Heel pad blood flow was assessed by laser-Doppler velocimetry. Mean blood flow was 463 +/- 106 in the denervated leg and 337 +/- 50 in the opposite (intact) leg (p less than 0.01). Flow in the denervated leg decreased 78 percent (463 +/- 106 to 100 +/- 23) within 5 minutes of @entity1063 administration and did not return to normal for 30 minutes. @entity1063 administration in the presence of 1 and 3 hours of @entity63 decreased flow at 5 minutes to 6.6 and 6.0 percent of normal, respectively (31 +/- 14, 28 +/- 14, control 100 +/- 23; p less than 0.001). Administration of intraarterial @entity1063 distal to a femoral artery occluded for 1 and 5 minutes reduced flow following clamp release to 11.2 and 7.1 percent of normal 5 minutes after clamp release (52 +/- 9, 33 +/- 7, control 100 +/- 23; p less than 0.001). Comparison of the 1-minute and 5-minute groups to each other showed a significant flow decrease in the 5-minute group (p less than 0.007). This indicates that the observed decrease in flow was related both to the presence of a @entity432 and to the length of the occlusion.(ABSTRACT TRUNCATED AT 250 WORDS)
