XXXX due to limbal involvement in S  zary syndrome.

@entity1 @entity2194 @entity404 @entity2940 @entity706 @entity5 @entity784 @entity3138 @entity1035 @entity5893 @entity405 @entity281 @entity1892 @entity5823 @entity3283 @entity1442 @entity158 @entity3127 @entity4587 @entity1909
BACKGROUND: The majority of @entity2194 are @entity1892 . Ocular involvement by @entity784 is rare. We report a case of @entity1035 due to direct involvement of the corneal limbus by @entity706 in a @entity1 with S  zary syndrome. METHODS: A 58-year-old male with @entity784 presented with @entity158 , left-sided corneal ulceration, a dense infiltrate, severe epitheliopathy, hypopyon and a diffuse confluent @entity1909 involving the lids. He had a history of S  zary syndrome. Despite maximal treatment, this severe @entity3283 progressed to central @entity1035 . The eye was subsequently enucleated and submitted for histopathological examination. RESULTS: Histopathological examination confirmed corneal ulceration with perforation. There was an infiltrate of large atypical cells at the limbus, with tropism for the overlying epithelium. Immunohistochemical staining of these cells was positive for @entity3138 , CD3, @entity5893 , @entity404 and @entity4587 . Staining for @entity405 , @entity5823 and @entity2940 was negative. The appearances were those of an epitheliotrophic @entity784 , and were considered to represent spread from the @entity1 's underlying S  zary syndrome. The @entity1 died 2  months later from @entity3127 . CONCLUSIONS: Ocular involvement by @entity784 usually occurs in @entity1442 , and carries a poor prognosis. This @entity1 was immunocompromised due to advanced @entity5 , and there was a high suspicion of @entity281 as the primary cause of corneal ulceration. This case highlights that it is important to consider @entity5 as an initiating or contributing factor for corneal ulceration in such @entity1 .
