Sexual dimorphism in the effect of concomitant XXXX administration on changes caused by long-term @entity172 treatment in pituitary hormone immunoreactivities of @entity35 .

@entity172 @entity230 @entity308 @entity1420 @entity4743 @entity35 @entity4742
BACKGROUND: Since in clinical practice long-term @entity172 (E) treatment is frequently applied, our aim was to study the effect of concomitant @entity1420 (P) administration on changes caused by long-term @entity172 treatment in the secretion of LH, FSH, PRL and GH. MATERIAL/METHODS: @entity4742 ( @entity4743 ), P or both in silastic capsules were implanted under the skin of prepubertal Sprague-Dawley male and female @entity35 . Animals survived for two or five months. We have also studied whether the changed hormone secretion caused by @entity4743 can return to normal level 1 or 2 months after removing @entity4743 capsule. RESULTS: 1.) The males more rapidly responded than females with decreasing basal LH release upon treatments. The basal FSH release was decreased only in males. The effect of @entity4743 persisted in males; however, in females basal LH and FSH levels were upregulated after removal of @entity4743 capsule. 2.) The basal GH levels were low in each group. The body weight and length were @entity308 by @entity4743 in both genders and P little blunted this effect. The body weight and length in males remained low after removal of @entity4743 capsule, in females it was nearly similar to intact @entity35 . 3.) There was no sexual dimorphism in the effect of @entity230 on PRL secretion. In both genders @entity4743 extremely enhanced the PRL levels, P prevented the effect of @entity4743 . PRL levels returned to intact value after removal of @entity4743 influence. 4.) Removal of @entity4743 capsule reversed the changes in the immunohistochemical appearance of hormone immunoreactivities. CONCLUSIONS: There was sexual dimorphism in the change of basal gonadotropic hormone and GH secretion but not of PRL upon @entity4743 and @entity4743 +P treatments. P was basically protective and this role may be mediated by P receptors locally in the pituitary gland.
