Reproducibility of native myocardial T1 mapping in the assessment of XXXX and its role in early detection of cardiac involvement by cardiovascular magnetic resonance.

@entity1 @entity2314 @entity4346 @entity1184
BACKGROUND: Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in @entity1 with @entity2314 even before @entity4346 ( @entity4346 ) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship of native T1 lowering prior to @entity1184 and other candidate early phenotype markers are unknown. Furthermore, the reproducibility of T1 mapping has never been assessed in @entity2314 . METHODS: Sixty-three @entity1 , 34 (54%) female, mean age 48  15 years with confirmed (genotyped) @entity2314 underwent CMR, ECG and echocardiographic assessment. @entity4346 was absent in 25 (40%) @entity1 . Native T1 mapping was performed with both Modified Look-Locker Inversion recovery (MOLLI) sequences and a shortened version (ShMOLLI) at 1.5 Tesla. Twenty-one @entity1 underwent a second scan within 24 hours to assess inter-study reproducibility. Results were compared with 63 healthy age and gender-matched volunteers. RESULTS: Mean native T1 in @entity2314 ( @entity4346 positive), ( @entity4346 negative) and healthy volunteers was 853  50 ms, 904  46 ms and 968  32 ms (for all p<0.0001) by ShMOLLI sequences. Native T1 showed high inter-study, intra-observer and inter-observer agreement with intra-class correlation coefficients (ICC) of 0.99, 0.98, 0.97 (ShMOLLI) and 0.98, 0.98, 0.98 (MOLLI). In @entity2314 @entity4346 negative individuals, low native T1 was associated with reduced echocardiographic-based global longitudinal speckle tracking strain (-18  2% vs -22  2%, p=0.001) and early diastolic function impairment (E/E'=7 [6-8] vs 5 [5-6], p=0.028). CONCLUSION: Native T1 mapping in @entity2314 is a reproducible technique. T1 reduction prior to the onset of @entity4346 is associated with early diastolic and systolic changes measured by echocardiography.
