XXXX and @entity935 colocalization with @entity1063 in various peripheral tissues: @entity2997 effects.

@entity2997 @entity935 @entity1425 @entity4478 @entity2922 @entity35 @entity2661 @entity1063
Chemical sympathectomy with @entity2997 (Gnt) selectively destroys the postganglionic noradrenergic neurons, whereas dopaminergic fibers and nonneural @entity2922 -secreting cells are spared. As a result, the relative proportions of @entity1063 (NE), @entity1425 (E), and @entity935 (DA) in tissues can be differentially affected. This study was done to show the possible differences in the relative amount of @entity2661 in some organs and tissues that might indicate the nature of the secretory cells from which they originate. The contents of NE, E, and DA were assessed in @entity35 neonatally treated with Gnt. Gnt-treated @entity35 showed significantly lower levels of NE (P < 0.01) in all tissues except the adrenal gland and paraganglia. @entity1425 was present in all tissues with mean levels below 25 ng/g, with the exception of the adrenal gland (700 microg/gland) and paraganglia (100 ng/g). Only the heart showed lower values in Gnt-treated @entity35 . Mean DA levels were also very high in paraganglia (530 ng/g). In the Gnt-treated @entity35 , DA levels fell practically to zero except in the duodenum, mesentery, and adrenal, whereas there were high levels in the paraganglia, which were significantly different from controls. The results suggest that the three @entity2661 are contained mainly in noradrenergic sympathetic fibers of muscle, white adipose tissue, heart, liver, pancreas, and spleen. The duodenum and mesentery may have dopaminergic fibers or E- and DA-containing nonneural cells. Hepatic-vagus paraganglia contain all the @entity2661 in relatively high amounts in nonneural cells, and Gnt treatment raises DA levels without affecting the other @entity4478 .
