[A @entity19 model of XXXX (VI TA2MA-891) with high rate of spontaneous metastases in the lungs].

@entity5 @entity19 @entity786 @entity71354 @entity1732 @entity420 @entity1487
The primary donor @entity5 was a spontaneous @entity5 which arose in a 348-day-old female @entity71354 @entity19 . The pedigree number of that @entity19 was 0901-1423. The @entity19 was sacrificed for serial s.c. transplantation with 3 isogeneic hosts on January 19, 1989 and a total of 27 generations succeeded by the end of April, 1992. The primary donor @entity5 was diagnosed pathologically as a type B @entity19 @entity420 (Dunn 1959). The incidence of this serial s.c. transplantation @entity5 is 100% after inoculation. The latency period is 4-7 days and the lifetime of tumorbearing @entity19 is about 47 days. The spontaneous metastatic rates in the lungs was 100% after the 11th generations. The earliest metastasis seen in the lung under light microscopy was on the 10th day after inoculation, and the earliest seen by gross examination was on about the 35th day. The transplanted @entity5 grew slowly from the 4th day to the 21st day after inoculation and then grew rather fast from the 22nd to the 47th day. The average size of the transplanted @entity5 obtained from 10 recipient @entity19 on the 47th day after inoculation was 4.93cm3. Seven anticancer drugs were administered respectively for a sensitivity test. The taking rates of the transplanted @entity5 using 4 of the 7 drugs were as follows: @entity1487 29.27% (P < 0.05); thio-tepa 44.80% (P < 0.01); @entity786 95.31% (P < 0.01); and @entity1732 96.27% (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
