Six-year analysis of compliance to weekly concurrent chemoradiotherapy in XXXX .

@entity1 @entity135 @entity5 @entity900 @entity213
OBJECTIVES: To evaluate treatment compliance to weekly concurrent chemoradiotherapy (CRT) in @entity213 ( @entity213 ). STUDY DESIGN: Retrospective analysis. SETTING: Tertiary care hospital. MAIN OUTCOME MEASURES: Overall treatment time (OTT), acute radiation morbidity and treatment completion rate without prolongation of overall treatment time of more than 2 days. RESULTS: Three hundred and seventy-eight @entity135 @entity1 treated with radical CRT with 70 Gy/35 fractions of radiotherapy with weekly @entity900 40 mg/m(2) were included in the study. Median age was 52 years (range 22-77 years), oropharynx was most commonly (54%) involved site, and 55% were in stage IV disease. Majority (86%) of @entity1 were able to complete @entity5 -directed therapy, median OTT was 52 days (46-140 days). Nineteen per cent of @entity1 completed treatment without prolongation of OTT beyond 2 days and 68% of @entity1 there completed treatment prolongation of OTT beyond 7 days. Nearly, sixty-six of the @entity1 experienced grade II or higher acute radiation morbidities. CONCLUSIONS: Delivery of weekly low-dose concurrent CRT is safe and feasible. Two-thirds of the @entity1 experienced treatment prolongation of more than 2 days and 14% could not complete treatment. Results within in the study suggest to a greater need to lay emphasis on continuity of a course of radical CRT for @entity213 .
