Effects of central alpha 2-adrenergic agonists on systemic haemodynamics and on baroreceptor reflex sensitivity in spontaneously XXXX rats.

@entity1 @entity101 @entity1338 @entity1774 @entity551 @entity947 @entity4288
@entity1338 , an @entity947 derivative, is a widely used antihypertensive agent which acts by stimulating the alpha 2-adrenergic receptors at the central nervous system. @entity1338 also seems to exert beneficial effects on baroreceptor reflex sensitivity which is usually altered by arterial systemic @entity101 and @entity4288 . Aim of the study was to compare acute and chronic @entity551 response and the effects on baroreflex sensitivity of a newly synthesized central alpha 2-adrenergic agonist, @entity1774 , with those induced by @entity1338 . The effects of acute and chronic treatment were studied by evaluating blood pressure modifications through intraarterial or sphygmomanometric detection. Baroreflex sensitivity was studied before and after acute treatment with the two drugs. Our results show that @entity1774 and @entity1338 may induce comparable effects, both reducing arterial blood pressure levels and heart rate with an order of potency for @entity1774 10 times lower than @entity1338 . After chronic treatment the effect of @entity1774 on blood pressure was more pronounced than that observed after @entity1338 administration. Both drugs may enhance baroreflex sensitivity, with a more evident effect of @entity1774 than @entity1338 in response to a @entity551 . This suggests that @entity1774 could afford a more effective cardiovascular adaptation during acute @entity551 (i.e. during @entity551 ), particularly in the elderly @entity101 @entity1 .
