Early and Degressive Putamen Atrophy in XXXX .

@entity1 @entity3780 @entity194 @entity810 @entity15
Putamen @entity194 and its long-term progress during disease course were recently shown in @entity1 with @entity15 ( @entity15 ). Here we investigated retrospectively the time point of @entity194 onset in @entity1 with @entity3780 ( @entity3780 ). 68 @entity1 with @entity3780 and 26 healthy controls (HC) were admitted to 3T MRI in a cross-sectional study. We quantitatively analyzed the putamen volume of individual @entity1 in relation to disease duration by correcting for age and intracranial volume (ICV). @entity1 's relative putamen volume (RPV), expressed in percent of ICV, was significantly reduced compared to HC. Based on the correlation between RPV and age, we computed the age-corrected RPV deviation (  RPV) from HC. @entity1 showed significantly negative   RPV. Interestingly, the age-corrected   RPV depended logarithmically on disease duration: Directly after first symptom manifestation, @entity1 already showed a reduced RPV followed by a further degressive @entity810 . This means that @entity194 progression was stronger in the first than in later years of disease. Putamen @entity194 starts directly after initial symptom manifestation or even years before, and progresses in a degressive manner. Due to its important role in neurological functions, early detection of putamen @entity194 seems necessary. High-resolution structural MRI allows monitoring of disease course.
