Clinical value of wireless pH-monitoring of gastro-esophageal reflux in XXXX before and after proton pump inhibitors.

@entity1 @entity1875 @entity354
BACKGROUND: Wireless pH-monitoring is an accurate method for diagnosing adults with @entity354 ( @entity354 ). The aim of this study was to evaluate the use of the Bravo capsule on @entity1 investigated for @entity354 in terms of safety, tolerability and feasibility before and after administration of proton pump inhibitors. METHODS: A Bravo capsule was inserted during upper endoscopy under general anaesthesia or deep sedation with @entity1875 . 48-hour pH-metry was performed in 106 @entity1 (50 males, 56 females) at the median age of 11  years (range 17  months-18  years). On the second day of investigation, proton pump inhibitor (PPI) was given at a mean dose of 1.6  mg/kg (SD   0.6  mg). The definition of @entity354 was set to a reflux index (RI) of >= 5% and DeMeester score (DMS) >= 14.7. RESULTS: Application of the capsule was successful in 103 of the 106 @entity1 (97.2%) and interpretable in 99 of these 103 (96.1%). 49 of the @entity1 with interpretable results (49.5%) had @entity354 according to RI, while 51 (56.7%) had @entity354 according to DMS. After PPI was given on day 2, RI decreased from a median of 4.9% (range 0.3-63.4%) to 2.2% (0-58.0%), while DMS decreased from a median of 17.6 (range 2.2-207.6) to 8.2 (0.3-178.6), respectively (p <   0.0001). No severe adverse events were reported. CONCLUSION: Wireless pH-metry is a safe and tolerable method when investigating @entity1 for @entity354 . PPI given on the second day of assessment provides additional information on response to treatment suggesting that pH-metry preferably should be extended to 48  hours.
