Expression of @entity7952 and pAKT in @entity1 @entity816 : correlation with @entity818 - @entity28485 presence, XXXX , microvascular characteristics and clinical outcome.

@entity1 @entity894 @entity7 @entity5 @entity7952 @entity818 @entity982 @entity816 @entity28485 @entity463 @entity9275
Although @entity7952 and pAKT are reportedly activated in various @entity5 , little information is available about their significance in @entity816 . @entity982 -embedded tissue from 82 @entity1 with diffuse infiltrating @entity816 (grades II to IV) was investigated for the association of @entity7952 and pAKT activation with clinicopathological features, @entity7 ( @entity7 ), @entity9275 dehydrogenase 1 and microvascular parameters. Nuclear @entity7952 @entity894 ( @entity894 ) increased with increasing cytoplasmic @entity7952 @entity894 and nuclear and cytoplasmic pAKT @entity894 (p   =   0.0019, p   =   0.0260 and p   =   0.0012, respectively). Accordingly, cytoplasmic @entity7952 increased with increasing levels of nuclear (p   =   0.0001) and marginally with cytoplasmic pAKT @entity894 (p   =   0.0526). Nuclear and cytoplasmic @entity7952 @entity894 and nuclear pAKT @entity894 were positively correlated with @entity5 histological grade (p   =   0.0040, p   =   0.0238 for @entity7952 and p   =   0.0004 for pAKT, respectively). @entity7 expression was correlated with nuclear @entity7952 (p   =   0.0099) and nuclear pAKT @entity894 (p   =   0.0002). Interestingly, @entity7952 cytoplasmic @entity894 increased with microvessel calibre (p   =   0.0287), whereas pAKT nuclear @entity894 was marginally related to microvessel density (p   =   0.0685). The presence of @entity818 - @entity28485 was related only to histological grade and lower microvessel calibre. Multivariate survival analysis in the entire cohort selected cytoplasmic pAKT @entity894 (p   =   0.045), histological grade, microvessel calibre (p   =   0.028), @entity1 ' age, gender and surgical excision as independent predictors of survival. Moreover, in @entity463 , @entity7952 nuclear @entity894 emerged as a favourable prognosticator in the presence of @entity818 - @entity28485 . @entity7952 and pAKT in @entity816 are interrelated and associated with @entity5 grade and angiogenesis. Moreover, the importance of cytoplasmic pAKT immunoexpression in @entity1 ' prognosis and nuclear @entity7952 immunoexpression in @entity463 is confirmed.
