Change in circulating cytokines after 2 forms of exercise training in chronic stable XXXX .

@entity1 @entity650 @entity712 @entity39 @entity310 @entity1851
BACKGROUND: A proinflammatory state is recognized in @entity712 and the degree of immune activation corresponds to disease severity and prognosis. Training is known to improve symptoms in @entity712 but less is known about the effects of specific forms of training on the proinflammatory state. METHODS: Forty-six @entity1 with stable @entity712 underwent a home-based program of exercise training for 30 minutes a day, 5 days per week over a 6-week period. Twenty-four used a bicycle ergometer and 22 used an electrical muscle stimulator applied to quadriceps and gastrocnemius muscles. Tumour @entity39 factor-alpha ( @entity310 ), @entity310 soluble receptors 1 and 2, @entity650 , and @entity1851 were measured before and after the training period. RESULTS: Significant improvements in markers of exercise performance were seen in both training groups. Soluble @entity310 receptor 2 levels decreased after training in the bike group only (2900 +/- 1069 pg/mL to 2625 +/- 821 pg/mL, P =.013). Trends towards a decrease in levels of @entity310 and soluble receptor 1 were also seen in the bike group only. No change in circulating inflammatory markers was observed after stimulator training. CONCLUSIONS: Physical training improves exercise capacity for @entity1 with @entity712 but degree of attenuation of the proinflammatory response may depend on the mode of training despite similar improvements in exercise capacity.
