Cycled light in the intensive care unit for preterm and low birth weight XXXX .

@entity1 @entity400 @entity2132 @entity989 @entity3917
BACKGROUND: The potential benefits and harms of different lighting in neonatal units have not been quantified. OBJECTIVES: To compare the effectiveness of cycled lighting ( @entity3917 ) (approximately 12 hours of light on and 12 hours of light off) with irregularly dimmed light or @entity400 ( @entity400 ) and with continuous bright light (CBL) on growth in preterm @entity1 at three and six months of age. SEARCH STRATEGY: Electronic searches of the literature were conducted (in May 2010) of the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE, CINAHL and abstracts from Pediatric Academic Societies' annual meetings. SELECTION CRITERIA: Randomised or quasi-randomised trials of @entity2132 or CBL in preterm and low birth weight @entity1 . DATA COLLECTION AND ANALYSIS: Data collection and analyses were performed according to the methods of the Cochrane Neonatal Review Group. MAIN RESULTS: Five studies enrolling 387 @entity1 compared @entity3917 to @entity400 . No study reported on weight at three or six months. In one study (n = 40) there was no statistically significant difference in weight at four months between the @entity3917 and the @entity400 groups. In another study (n = 62) the ratio of day-night activity prior to discharge favoured the @entity3917 group (mean difference 0.18, 95% CI 0.17 to 0.19) indicating 18% more activity during day than night in the @entity3917 group compared to the @entity400 group. Two studies (n = 189) reported on @entity989 (stage >=  3). There was no statistically significant difference between the @entity3917 and @entity400 groups (typical RR 0.53, 95% CI 0.25 to 1.11, I(2) = 0%; typical RD -0.09, 95% CI -0.19 to 0.01, I(2) = 0%).Two studies enrolling 82 @entity1 compared @entity3917 to CBL. One study (n = 41) reported higher mean weight at three months corrected age in @entity1 cared for in the @entity3917 nursery (P < 0.02) and lower mean number of hours spent awake in 24 hours at three months (P < 0.005). In one study (n = 41) days on a ventilator were reduced in the @entity3917 group (mean difference -18, 95% CI -31 to -5 days).For many outcomes the trends favoured @entity2132 as well as @entity3917 versus CBL. AUTHORS' CONCLUSIONS: Trials assessing the effect of @entity3917 have enrolled 469 @entity1 . Trends for many outcomes favoured @entity3917 ( @entity3917 ) compared to @entity400 ( @entity400 ) and @entity3917 compared to continuous bright light (CBL) The studies may have lacked significance due to a lack of statistical power. Future research should focus on comparing @entity3917 to @entity400 .
