[ XXXX : classification and aspects of the proliferation kinetics].

@entity2558 @entity1803 @entity3079 @entity5 @entity957 @entity2580 @entity189 @entity14 @entity420
The exact @entity5 classification by the pathologist is the basis of adequate therapy of @entity14 . The classification includes the determination of the histological type of the @entity189 and the grading according to the criteria of the WHO and the UICC, as well as the staging according to the TNM system of the UICC and the Dukes classification. Most @entity14 are @entity420 of tubular, tubulo-papillary and papillary subtypes. @entity3079 are characterized by a pronounced extracellular mucus production. @entity2580 with intracellular mucus production are very rare and predominantly localized in the right-sided colon. @entity957 and @entity957 are extremely rare in the large bowel. They are only mentioned for completeness. The histological grading proposed by the WHO distinguishes @entity189 of well (G1), moderately well (G2) and poor (G3) differentiation. Well and moderately well differentiated @entity5 can be regarded as @entity189 with low grade of @entity5 , whereas poorly differentiated ones are @entity189 with high grade of @entity5 . The new grading of the UICC distinguishes in addition to the well, moderately well and poorly differentiated @entity189 the @entity5 (G4). G1 and G2 correspond to low grade, G3 and G4 to high grade of @entity5 . According to the 1987 nomenclature of the UICC-TNM system @entity2558 denotes @entity5 spread to the mucosa, or mucosa and submucosa, pT2 to the muscularis propria, @entity1803 into the subserosa or into nonperitonealized pericolic or perirectal tissue and pT4 a perforation of the visceral peritoneum or a spread into other organs.(ABSTRACT TRUNCATED AT 250 WORDS)
