Incremental angiogenesis assessed by color Doppler ultrasound in the tumorigenesis of XXXX .

@entity5 @entity43 @entity2971
BACKGROUND: The crucial role of angiogenesis in @entity5 behaviour has been studied extensively in vitro. The authors assessed the in vivo angiogenesis in @entity43 by color Doppler ultrasound and waveform analysis. METHODS: The intratumor artery resistance index (RI) of 222 @entity43 referred for color Doppler ultrasound evaluation was measured, and the corresponding histopathologic diagnosis was recorded. RESULTS: Satisfactory intratumor artery waveforms were obtained at an average of 1.12 sites in 44.7% (68 of 152) of @entity5 and at 6.28 sites in 97.1% (68 of 70) of the malignant group. Great heterogeneity in RI values existed. The RI of the intratumor artery in the benign group during the follicular phase (mean, 0.678) was significantly higher (P < 0.001) than that of the luteal phase (mean, 0.414), @entity43 (n = 34; mean, 0.402), @entity2971 (n = 6; mean, 0.413), @entity5 metastasized to the ovary (n = 18; mean, 0.357), and other rare @entity5 (n = 4; mean, 0.435). The RI of primary @entity43 (n = 41; mean, 0.411) was significantly higher than that of @entity5 metastasized to the ovary (P < 0.05). The RI values of epithelium-originated @entity5 showed a significant incremental decrease from @entity5 (n = 48; mean, 0.695) toward borderline @entity5 (n = 6; mean, 0.535; P < 0.01), early-stage @entity43 (n = 10; mean, 0.485; P < 0.01), and, finally, to advanced-stage @entity43 (n = 29; mean, 0.398; P < 0.05). CONCLUSIONS: Angiogenesis is a common phenomenon in @entity43 , but the intensity of neovascularization may depend on individual @entity5 characteristics. The authors documented the incremental decrease of the resistance index in @entity43 , which may reflect the increase in angiogenesis intensity as an indication of malignant potential.
