Long-term results after conversion from calcineurin inhibitors to XXXX in renal transplant @entity1 .

@entity1 @entity644 @entity137 @entity102 @entity3446 @entity1011
BACKGROUND: Calcineurin inhibitors (CNI) toxi @entity137 one of the contributing factors for the development and progression of chro @entity102 D) @entity102 onversion to siro @entity3446 L) from CNI improves renal function kidney in transplant recipients. METHODS: A retrospective review from pati @entity1 uptly converted from CNI to SRL over a three yr period is reported. RESULTS: Thirty-nine pati @entity1 e converted 55.2  58 months after renal transplantation. 24 month pati @entity1 graft survival was 100% and 92%. Acute rejection incidence was 7.6%. Overall, serum crea @entity1011 r) and Cockcroft-Gault crea @entity1011 arance (CGCrCl) improved. In responders, SCr improved from 2.48  0.8 to 1.94  0.8 mg/dL (p<0.05) CGCrCl improved from 37.8  17.4 to 51.9  23.8 mL/min at two years. An increase in prot @entity644 observed from conversion to month 12 in responders (189.4  512.8 to 488.3  890.6 mg/day, p<0.05) and from conversion to month six in non-responders (1179.4  2001.1 to 2357  4172.9 mg/day, p<0.05). Low prot @entity644 positive predictive value for renal response after conversion. CONCLUSION: Conversion from CNI to SRL with CAD @entity102 associated with improved renal function with an increase in prot @entity644 w prot @entity644 a possible positive predictive factor for successful conversion.
