Daily concurrent preoperative chemoradiotherapy with docetaxel (D) and cisplatin (C) using new superselective intra-arterial infusion via superficial temporal artery for stage III, XXXX .

@entity1 @entity135 @entity137 @entity882 @entity5 @entity33 @entity1431 @entity432 @entity1909
UNASSIGNED: 5529 Background: Combined radiotherapy and intra-arterial chemotherapy for @entity135 is currently performed using the Seldinger method. However, chemotherapy and radiotherapy cannot be performed simultaneously on a daily basis because long-term catheterization is not possible. Therefore, we developed a new method based on superselective intra-arterial infusion via the superficial temporal artery and preoperatively performed daily concurrent radiotherapy and chemotherapy with D and C using this method for stage III, @entity135 . METHODS: Thirty-eight @entity1 with @entity5 were treated. The new catheter was prepared by modifying an angiographic catheter measuring (1.35 mm) in diameter. It was inserted superselectively to the feeding artery of the @entity5 via the superficial temporal artery using a guide wire. Long-term catheterization is possible using this method. Radiotherapy (total dose: 40 Gy) and superselective intra-arterial infusion chemotherapy using D (total dose: 60 mg/m2) and C (total dose: 100 mg/m2) were performed concurrently daily, followed by surgery. RESULTS: Intra-arterial infusion was successful in 35 @entity1 , but unsuccessful in 3 @entity1 due to @entity432 . Grade 3 @entity137 were noted for @entity1431 (6.5%), @entity882 (3.2%), @entity33 (12.9%), and @entity1909 (6.5%). No infection was observed during catheterizaition, and no major complications were observed. The clinical efficacy was CR in 28 (80.0 %) @entity1 and PR in 7 (20.0 %), and histopathology of the resected @entity5 indicated pathological CR in 31 (88.6 %), and pathological PR in 4 (11.4 %). The 4-year cumulative survival rate was 82.9 %. This survival rate is higher than the rate of conventional therapy. CONCLUSIONS: This superselective intra-arterial infusion allows for long-term catheterization, unlike the Seldinger method, so that chemotherapy can be performed simultaneously with radiotherapy. This method promises to be the strategy of choice for the treatment of stage III, @entity135 . No significant financial relationships to disclose.
