XXXX in the Autopsied Brains of @entity1 30 to 50 Years of Age.

@entity1 @entity527 @entity66 @entity2204 @entity303 @entity3072 @entity195
OBJECTIVE: To test the hypothesis that asymptomatic @entity66 may appear before 50 years of age. BACKGROUND: @entity195 has an asymptomatic stage during which @entity1 are cognitively intact despite having substantial pathologic changes in the brain. While this asymptomatic stage is common in older @entity1 , how early in life it may develop has been unknown. METHODS: We microscopically examined the postmortem brains of 154 @entity1 aged 30 to 39 years (n=59) and 40 to 50 years (n=95) for specific @entity195 : beta-amyloid plaques, @entity3072 , and tau-positive neurites. We genotyped DNA samples for the @entity2204 gene ( @entity2204 ). RESULTS: We found beta-amyloid lesions in 13 brains, all of them from @entity1 aged 40 to 49 with no history of @entity303 . These plaques were of the diffuse type only and appeared throughout the neocortex. Among these 13 brains, five had very subtle tau lesions in the entorhinal cortex and/or hippocampus. All individuals with @entity527 carried one or two @entity2204 alleles. Among the individuals aged 40 to 50 with genotype @entity2204 /4, 10 (36%) had @entity527 but 18 (64%) had none. CONCLUSIONS: Our study demonstrates that @entity527 in the cerebral cortex appear as early as 40 years of age in @entity2204 carriers, suggesting that these lesions may constitute a very early stage of @entity195 . Future preventive and therapeutic measures for this disease may have to be stratified by risk factors like @entity2204 genotype and may need to target @entity1 in their 40s or even earlier.
