Effect of AEM energy applicator configuration on magnetic nanoparticle mediated XXXX for breast cancer.

@entity5 @entity1933 @entity221
Magnetic nanoparticle mediated low heat @entity221 (42~45( o )C) via alternating electromagnetic (AEM) energy is a promising, @entity5 specific and minimally-invasive @entity5 therapy. @entity1933 particles frequently used for this therapy are non-toxic and already used as a contrast agent for magnetic resonance imaging. One important issue in the @entity221 is applying an appropriate amount of @entity5 at various sizes and depths, with a minimal damage to normal tissue. For the therapy to be desirable, the AEM energy applicator needs to be non-invasive and user-friendly. To better understand the effect of the probe on the magnetic field distribution, computer simulation was performed for the field distribution by probes with various configurations. In a solenoid-type probe, the field is mainly inside the probe and, therefore, is difficult to use on body. A pancake-shaped probe is easy to use but the field penetration is shallow and, thus, may better serve surface @entity5 treatment. A sandwich probe, composed of two pancake probes, has a penetration depth deeper than a pancake probe. The results also showed that the spacing between two adjacent coils and the number of coil turns are very important for controlling the field penetration depth and strength. Experiments were also performed to study the effects of the size and concentration of @entity1933 nanoparticles on heating. Among the tested particle sizes of 10~50 nm, 30 nm particles showed the best heating for the same mass.
