@entity834 after surgery for @entity5 : a risk factor for local recurrence, distant XXXX and reduced @entity5 -specific survival?

@entity1 @entity834 @entity2680 @entity5 @entity3
AIM: The impact of @entity2680 ( @entity2680 ) on the oncological outcome after anterior resection (AR) for @entity5 is still controversial. We explored the impact of @entity2680 regarding local recurrence (LR), distant @entity3 and overall recurrence (OAR). Overall and @entity5 -specific survival was analysed. METHOD: @entity1 undergoing AR for @entity5 with a registered @entity2680 between 1995 and 1997 and a control group were identified in the Swedish @entity5 Registry. The medical records were retrieved for additional data and validation. Differences in the oncological outcome at 5-year follow-up were analysed with multivariate methods. RESULTS: After validation, 114 @entity1 with @entity2680 and 136 control @entity1 with locally radical surgery for @entity5 in @entity5 -node- @entity3 stages I-III were analysed. There was no difference detected between @entity1 with @entity2680 and control @entity1 regarding rates of LR [8% (9 of 114) vs 9% (12 of 136); P = 0.97], distant @entity3 [18% (20 of 114) vs 23% (31 of 136); P = 0.37] and OAR [19% (22 of 114) vs 28% (38 of 136); P = 0.15]. The 5-year @entity5 -specific survival was almost 80% in both groups. In multivariate analysis, @entity2680 was not a risk factor of LR, distant @entity3 or OAR and had no impact on 5-year overall or 5-year @entity5 -specific survival. Irrespective of the occurrence of @entity2680 , preoperative radiotherapy (P = 0.055) and rectal washout (P = 0.046) reduced the LR rate, but did not influence survival. CONCLUSION: @entity834 was not proved to be a risk factor of worse oncological outcome. Hence, additional adjuvant treatment or extended follow-up on the basis of the occurrence of @entity2680 after AR might not be justified.
