Liposomal aerosols in the management of XXXX .

@entity137 @entity6923 @entity2379 @entity19 @entity71099 @entity262 @entity358
The combination of liposomes and aerosols has been utilized to directly target the lungs with chemotherapeutic agents that might not have been used because of low solubility or @entity137 . There are a variety of antibacterials, antifungals, and antivirals that have good in vitro activity, but are not effective because of their systemic @entity137 and/or poor penetration into the lungs. Incorporation of many lipophilic drugs into liposomes decreases their @entity137 without affecting effectiveness, thus increasing the therapeutic index. We have focused on aerosol delivery of @entity2379 (ampB) for the treatment of @entity358 . We have tested a variety of ampB-lipid formulations for the optimal treatment regimen for Cryptococcus and @entity6923 in @entity19 models. The AeroTech II nebulizer (MMADs of 1.8-2.2 microns) produced aerosols with the highest concentrations in the breathable range. Pharmacokinetic studies revealed that pulmonary drug was present for hours to weeks. AmBisome retained its anticryptococcal activity even when animals were challenged 14 days after aerosol treatment. @entity71099 may also be effective in @entity262 . In our Candida- @entity19 model, @entity6923 and mortality were reduced by aerosolized ampB-liposome treatment. The ability to utilize lipophilic drugs, to deliver high concentrations of drug directly to the site of infection, and to reduce @entity137 makes aerosol liposomes an attractive, alternative route of administration.
