Occurrence of unrecognized XXXX in subjects aged 45 to 65 years (the ARIC study).

@entity1 @entity301 @entity731 @entity63 @entity1188 @entity583
Previous observational studies conducted predominantly in white @entity1 before 1988 estimated that 20% to 40% of @entity583 ( @entity583 ) are unrecognized. Recent data on the proportion of @entity583 that are unrecognized, especially in @entity1 and African-Americans, are largely unavailable. @entity1 in the @entity731 Risk in Communities (ARIC) study were @entity1 and @entity1 , aged 45 to 65 years, who were free of clinically recognized @entity301 and electrocardiographic evidence of MI at baseline (n = 12,843). Three follow-up clinic examinations were conducted approximately 3, 6, and 9 years after baseline, and included a 12-lead electrocardiogram at rest. Electrocardiographic evidence of @entity1188 was defined as the appearance between the baseline and subsequent examinations of a major Q wave or a minor Q wave with @entity63 changes. Clinically recognized (hospitalized) MI events were also identified and validated. Incident unrecognized MI was defined as electrocardiographic evidence of MI before, or in the absence of, a clinically recognized MI during the follow-up period. Of 508 @entity583 , 20% were unrecognized (95% confidence interval 16% to 23%), with African-Americans having a slightly higher percentage (23%) than whites (19%). The percentage of unrecognized @entity583 in @entity1 and @entity1 was similar. The percentage of unrecognized @entity583 in the ARIC sample between 1987 and 1998 was slightly lower than previous estimates from other populations.
