Prognostic Value of Ki-67 Labeling Index and Postoperative Radiotherapy in WHO XXXX .

@entity1 @entity1653 @entity894 @entity347
OBJECTIVE: This study was performed to determine the clinical significance of the Ki-67 @entity894 ( @entity894 ) for local control (LC) in @entity1 with World Health Organization (WHO) @entity1653 . We also tried to discern the effect of postoperative radiotherapy (PORT) on LC depending upon the Ki-67 @entity894 value. MATERIALS AND METHODS: The medical records and values of Ki-67 LIs were retrospectively reviewed for 50 @entity1 who underwent surgical resection of intracranial WHO grade II @entity1653 at Samsung Medical Center from May 2001 to December 2012. Forty-three @entity1 (86%) were treated with immediate PORT. The median total radiation dose was 60 Gy (range, 54 to 60 Gy). RESULTS: The median follow-up was 47.4 months. The mean Ki-67 @entity894 was 13% (range, 1% to 47%). Twelve @entity1 (24.0%) showed local failure, and 8 @entity1 (16.0%) experienced local failure even after PORT. The mean Ki-67 @entity894 was 15% in @entity1 with local failure (n=12) and 12% in @entity1 without local failure (n=38). The 3-year actuarial LC was 80.5%. The 3-year overall survival was 89.5%. Ki-67 @entity894 >13% and PORT were significant prognostic factors for LC (P=0.015 and 0.009, respectively). In @entity1 with Ki-67 @entity894 >13% (n=17), PORT (n=14) improved LC (P<0.001). However, PORT (n=29) did not affect LC (P=0.412) for @entity1 with Ki-67 @entity894 <=13% (n=33). CONCLUSIONS: Ki-67 @entity894 can be a useful prognostic factor for LC in @entity347 . In @entity1 with Ki-67 @entity894 >13%, PORT should be recommended to improve LC.
