Determination of circulating XXXX cells for detection of @entity14 progression or recurrence.

@entity5 @entity1 @entity14
The role of circulating @entity5 cells (CTCs) in the management of @entity14 has not yet established. In present study, we aimed to investigate the relationship between clinicopathological characteristics and CTC levels in @entity1 with @entity14 . The isolation of CTCs in blood was performed with the semi-automated CellSearch System (Veridex TM). Ninety-three @entity1 were analyzed. Median age of @entity1 at the time of diagnosis was 56 (24-78). Total number of blood samples collected for CTCs were 130. CTCs were detected in 46 @entity1 (> or =1 per 7.5 mL), but only thirty (32%) @entity1 were interpreted as positive (> or = 3/7.5 mL). In the 27 @entity1 in whom 2 blood samples were taken, levels of CTCs were found to be decreased in 8 @entity1 , increased in 14 @entity1 and did not change in 5 @entity1 after therapy. Although only 2 (25%) of 8 @entity1 in whom CTCs decreased after therapy had disease progression, 13 (93%) of 14 @entity1 with increased CTCs had disease progression (p = 0.001). Similarly, 4 (80%) of 5 @entity1 with stable CTCs had also disease progression. Our findings indicate that decreased CTCs after therapy is related with remission while increased CTC level is associated with disease recurrence or progression.
