Role of lymphatic vessel density in XXXX : prognostic significance and clinicopathologic correlations.

@entity1 @entity2280 @entity5 @entity14
BACKGROUNDS AND AIMS: Over the past decades the identification of several molecules that are expressed specifically in the lymphatic endothelial cells has resulted in marked advances in the field of lymphangiogenesis. We aimed to measure LVD in @entity14 @entity1 and to compare it with microvascular density (MVD) - a marker of angiogenesis - and @entity1 ' clinicopathological parameters and survival, as the measurement of lymphatic vessel density (LVD) has been documented in various @entity5 types, including @entity14 . @entity1 AND METHODS: Fifty one @entity1 who had undergone surgical resection for stage I-III @entity14 entered this study. LVD and MVD were determined immunohistochemically with the use of D2-40 and @entity2280 antibody respectively. The evaluation of LVD was performed by both visual and computer-aided image analysis. RESULTS: The majority of lymphatic vessels were located in the peritumoral areas rather than within the @entity5 . The results obtained from the image analyzer correlated significantly with the data obtained using visual counting with light microscopy. Both visual and image analysis LVD failed to correlate with @entity1 ' age and gender and @entity5 location, stage, grade, MVD count and survival. CONCLUSIONS: The biologic role of the lymphatic vasculature in @entity5 progression remains controversial. The present study failed to associate LVD with outcome markers and prognosis and further studies would be required to verify our results.
