Unique features of early diastolic mitral annulus velocity in XXXX .

@entity1 @entity3822 @entity296 @entity2293
BACKGROUND: In most primary @entity296 , early diastolic mitral annulus velocity (E') decreases with disease progression. To our knowledge, @entity3822 ( @entity3822 ) is the only condition without this phenomenon. OBJECTIVE: This study was performed to evaluate the diagnostic and pathophysiologic role of mitral annulus velocity in @entity1 with @entity3822 . METHODS: In all, 17 @entity1 with @entity3822 (9 @entity1 ; mean age 46.5 +/- 14.3 years), 8 @entity1 with @entity2293 (Tamp) (2 @entity1 ; mean age 44.5 +/- 15.0 years), and age- and sex-matched control subjects for @entity3822 and Tamp were recruited for the study. Early mitral inflow velocity and E' were obtained while simultaneously recording respiration. In 8 @entity1 with @entity3822 and in all @entity1 with Tamp, these measurements were repeated after the relief of constrictive physiology or after pericardiocentesis. RESULTS: In @entity1 with @entity3822 , E' was significantly higher than it was for control subjects (12.9 +/- 3.0 cm/s vs 9.8 +/- 2.4 cm/s, P <.01). An E' of 2 cm/s higher than the predicted normal E' could differentiate @entity1 with @entity3822 from control subjects with a sensitivity of 76% and specificity of 82%. In 12 of 17 @entity1 (71%), inspiratory E' was higher than expiratory E'-the opposite of mitral inflow variation. In 8 @entity1 , E' decreased significantly after the relief of constrictive physiology (13.8 +/- 2.5 cm/s vs 9.3 +/- 3.1 cm/s, P <.05). In contrast, E' in the Tamp group was significantly lower than in the control group (6.8 +/- 1.6 cm/s vs 10.2 +/- 2.5 cm/s, P <.01), did not show significant respiratory variation, and increased significantly after pericardiocentesis (6.8 +/- 1.6 cm/s vs 9.5 +/- 3.0 cm/s, P <.05). CONCLUSION: E' is exaggerated in @entity3822 , which is helpful for diagnosis. The opposite phenomenon was noted in Tamp, a dissimilarity that might contribute to different hemodynamics.
