A variant of XXXX with acute, generalised presentation and persistent conduction blocks.

@entity1 @entity66 @entity73 @entity16 @entity305 @entity102 @entity1897 @entity281 @entity5011 @entity4163 @entity5363
OBJECTIVE: @entity1897 with persistent conduction blocks is classically described as a @entity102 @entity16 with progressive onset, and acute forms have not previously been characterised. We report four cases of severe @entity73 with acute and generalised onset and with persistent motor conduction blocks. @entity1 AND RESULTS: An acute tetraparesis with diffuse areflexia but little or no sensory disturbance was the clinical picture. Serial electrophysiological tests showed persistent multifocal motor conduction blocks with absent F waves in most tested motor nerves. No or minor @entity66 potentials were observed. Cerebrospinal fluid contained normal or mildly increased protein levels (<1 g/l) without cells. @entity5363 serology was negative in three @entity1 and consistent with past @entity281 in one patient. Anti- @entity4163 antibodies were positive in three @entity1 . A five day course of intravenous immunoglobulins produced nearly complete symptom resolution in three @entity1 and was ineffective in one @entity1 . CONCLUSION: Because of the persistence of multifocal motor conduction blocks for several weeks or months as the isolated electrophysiological feature, these cases could not be consistent with @entity5011 or @entity102 inflammatory demyelinating @entity305 . They suggest an original variant of @entity1897 with an acute and generalised initial presentation and persistent motor conduction blocks affecting all four limbs.
