Randomized clinical trials on the effects of dietary fat and @entity1735 on plasma lipoproteins and XXXX .

@entity1 @entity407 @entity101 @entity3363 @entity1674 @entity1735 @entity9539 @entity943 @entity65 @entity165
Several dietary approaches have reduced cardiovascular events in randomized clinical trials. Replacing saturated fat with polyunsaturated fat prevented coronary events in @entity1 , and a Mediterranean diet and fatty fish improved survival. None of these trials had much impact on total fat intake but rather increased vegetable oils, @entity9539 , or many other plant foods or nutrients that are linked to coronary prevention. The reductions in @entity65 ( @entity65 ) caused by these dietary therapies compare favorably with drug treatments for @entity407 and @entity101 . Improvement in blood lipid risk factors is an important mechanism to explain the results of trials of unsaturated fats. When saturated or trans unsaturated fats are replaced with monounsaturated or n-6 polyunsaturated fats from vegetable oils, primarily low-density lipoprotein (LDL) @entity165 decreases. The LDL to high-density lipoprotein (HDL) @entity165 ratio decreases. When @entity3363 are used to replace saturated fats, in a low-fat diet, LDL and HDL decrease similarly, and the ratio is not improved; @entity1674 increase as well when @entity1735 increases, except when low glycemic index foods are used. The n-3 polyunsaturated fats in fish oils suppress @entity943 and reduce @entity1674 , but they have little effect on LDL or HDL @entity165 levels. The theme should be that diet has benefits that come directly from foods, as well as from the reduction in saturated fats, @entity165 , meats, and fatty dairy foods. It is likely that many diets could be designed that could prevent @entity65 . This potential diversity is crucial for engaging the diverse cultures and tastes of @entity1 worldwide in @entity65 prevention.
