Serrated and non-serrated precursor lesions of XXXX .

@entity124 @entity17798 @entity4309 @entity1313 @entity75 @entity5 @entity984 @entity1412 @entity189 @entity817 @entity6523 @entity14 @entity652 @entity420
Although often viewed as a single disease, @entity14 more accurately represents a family of diseases with different precursor lesions. Conventional (tubular, tubulovillous and villous) @entity652 are the most common @entity1313 occurring in the large intestine. They have @entity1412 ( @entity1412 ) mutations and arise from dysplastic aberrant crypt foci, initially as @entity75 . In @entity5 , @entity5 follows the traditional pathway (chromosomal instability pathway), resulting in CpG island methylator phenotype (CIMP)-negative, @entity124 ( @entity124 ), @entity817 and @entity984 wild-type @entity5 . Germline mutations in the @entity1412 gene lead to @entity1412 . Conventional @entity652 are also the precursors of @entity4309 -associated microsatellite-instable ( @entity17798 -high) @entity5 . Sessile serrated @entity6523 (SSA/P) is the principal precursor lesion of the serrated pathway, in which @entity817 mutation can lead to @entity14 with @entity17798 -high CIMP-high or @entity124 CIMP-high phenotype. SSA/Ps have been associated with synchronous and metachronous invasive @entity420 as well as so-called interval @entity189 . Serrated @entity1412 is rare but most likely underdiagnosed. Affected individuals bear an increased but unspecified risk for the development of @entity14 ; close endoscopic surveillance is warranted. @entity652 ( @entity652 ) are much less common than the other serrated lesions. Cancers originating from @entity652 may show @entity984 mutation with a CIMP-high @entity124 phenotype.    2014 S. Karger AG, Basel.
