Changes to metabolite concentration in fetal @entity742 subjected to prolonged hypobaric XXXX .

@entity4095 @entity742 @entity948 @entity519 @entity880 @entity493 @entity413
The effect of hypobaric hypoxaemia on the concentration of metabolic substrates in the ovine fetus and pregnant ewe with implanted vascular catheters, was investigated. At 120 to 141 days of gestation @entity742 were subjected to hypobaria (mean fetal carotid @entity4095 12.7 +/- 0.7 torr; n = 9) or normobaria (mean fetal carotid @entity4095 22.7 +/- 0.7 torr; n = 11; P less than 0.001). At 141 days gestation mean fetal weight was 3.46 +/- 0.72 kg in the hypobaric group compared to 4.15 +/- 0.51 in the normobaric group (P less than 0.05). Concentrations of @entity413 in maternal and fetal plasma and @entity948 in fetal plasma were similar in hypobaric and normobaric fetuses. The concentration of @entity880 in fetal plasma rose from 1.68 +/- 1.34 to 8.79 +/- 5.8 mmol/l (P less than 0.001) within 24 h of onset of @entity519 , but fell to 3.36 +/- 1.13 mmol/l by day 3 of treatment, though still significantly above the concentration of @entity880 in the control fetuses (1.47 +/- 0.47; P less than 0.001). There was no significant effect of @entity519 on the concentration of @entity880 or @entity493 in maternal plasma. @entity493 concentration in the plasma of fetuses subjected to @entity519 significantly increased within 24 h of exposure (0.28 +/- 0.10 vs 0.58 +/- 0.39 mmol/l; P less than 0.01) and remained elevated for the duration of the study. There was no significant effect of gestational age on the concentration of metabolic substrates in either the control or experimental groups. @entity519 is associated with a sustained rise in the concentration of plasma @entity880 and @entity493 in the fetus.(ABSTRACT TRUNCATED AT 250 WORDS)
