Anti @entity6300 antibodies in XXXX .

@entity1 @entity644 @entity7110 @entity522 @entity6300 @entity1252 @entity1988 @entity3830
Autoantibodies against @entity6300 are strongly linked to @entity7110 like @entity1252 ( @entity1252 ). Although anti- @entity6300 antibodies have received much interest in the recent years, their biological functions remain unclear. Anti- @entity6300 antibodies are strongly associated with @entity1988 . Recent studies describe apoptosis as a key player in LE pathogenesis and @entity6300 is an important opsonin, playing a central role in the uptake of apoptotic blebs. The aim of this study was to evaluate serum anti @entity6300 antibodies, @entity6300 with circulating immune complexes and correlation between serology and cutaneous apoptosis in @entity1 with @entity3830 . MATERIAL AND METHODS: 79 subjects were recruited and divided into 4 groups-13 healthy controls, 26 with discoid chronic lupus (DLE), 23 with @entity1252 ( @entity1252 ) and 17 with @entity1252 ( @entity1252 ). Blood samples and skin punched-biopsy specimens were performed. Serum anti- @entity6300 antibodies and @entity6300 associated to the immune complexes concentrations were determined by ELISA. Cutaneous @entity522 expression was evaluated by immunohistochemistry. RESULTS: @entity1252 and @entity1252 @entity1 had significantly higher levels of anti- @entity6300 antibodies and serum @entity6300 -CIC levels when compared to healthy controls (p < 0.05). Serum anti- @entity6300 antibodies correlated with @entity644 in @entity1252 @entity1 (p < 0.05). Anti @entity6300 antibodies levels also correlated with cutaneous @entity522 expression in @entity1252 and @entity1252 @entity1 (both p < 0.05). CONCLUSIONS: Anti @entity6300 antibodies might play a pathogenic role in @entity1252 pathogenesis and being positively associated with cutaneous apoptosis markers might be associated with a negative prognosis and secondary @entity1252 development.
