A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced XXXX .

@entity1 @entity2313 @entity137 @entity353 @entity7324 @entity5 @entity219 @entity1149 @entity2 @entity900 @entity14 @entity1499 @entity1487 @entity1760
One hundred ninety-two @entity1 with previously untreated @entity5 (102 @entity1149 [ @entity1149 ]; 90 @entity14 ) were randomized to receive either ad lib nutritional intake (control group) or specific nutritional intervention during a 12-week study period when chemotherapy was administered. Those @entity1 randomized to nutritional interventions were counselled to take oral nutrients with caloric intake equal to 1.7 to 1.95 times their basal energy expenditure, depending on their pretreatment nutritional status ("standard" group). An augmented group was counselled to have a caloric intake equivalent to that of the standard group but with 25% of calories provided as protein and additional supplements of @entity219 and @entity1760 . Counselling increased caloric intake in both @entity5 types but reduced @entity353 in the short term only for @entity2 @entity1 . Ninety-three @entity1149 @entity1 were evaluable for @entity5 response to @entity7324 and @entity900 . Overall, only 20.4% of the @entity1 responded, and there were no significant differences in response rates, median time to progression, or overall duration of survival between the nutrition intervention groups and the control group. The @entity5 response rate to time-sequenced @entity1487 ( @entity1487 ) and @entity1499 in the 81 evaluable @entity1 with @entity14 was only 14.8%, and no significant differences in @entity5 response rates were noted between the three groups. Furthermore, the median time to progression and overall duration of survival were not different for the control, standard, and augmented groups. Nutritional interventions using dietary counselling had no impact on the percent of planned chemotherapy dose administered, the degree of @entity137 experienced by @entity1 , or the frequency of treatment delays. A multivariate prognostic factor analysis demonstrated that for @entity2 , the percent of @entity353 , serum @entity2313 concentration, and presence of liver metastases were significant (P less than .05) and independent prognostic variables for survival duration. For @entity14 , serum @entity2313 , alkaline phosphatase, lactic dehydrogenase (LDH) levels, and percent targeted caloric intake (TCI) were significant independent predictors of survival duration.
