A follow-up study of pulmonary function tests, bronchoalveolar lavage cells, and humoral and cellular immunity in XXXX .

@entity1 @entity404 @entity19998 @entity3794 @entity405
BACKGROUND AND OBJECTIVE: The long-term outcome of @entity19998 appears to be variable. The objective of this study is to clarify the sequelae of disease process in @entity19998 , with special reference to the humoral and cellular immune responses after avoidance of direct antigen exposure. METHODS: Five @entity1 with @entity19998 were studied for various parameters including pulmonary function tests, cellular profiles of bronchoalveolar lavage (BAL) fluids, determinations of antibodies in BAL fluids and sera, and antigen-induced proliferation of peripheral and bronchoalveolar lymphocytes during the 5 years of follow-up. RESULTS: Four of five @entity1 showed improvement in pulmonary function, and one showed marked deterioration. This @entity1 's room was close to the pigeon coop where her son was breeding pigeons, resulting in low-grade antigenic stimulation. Three @entity1 demonstrated an increase in @entity405 + cells in BAL fluid, but the remaining two showed an increase in @entity404 + cells. The levels of IgA antibodies remained unchanged, whereas IgG levels started declining after the first 3 years of follow-up. Antigen-induced proliferation of BAL lymphocytes from all five @entity1 and blood lymphocytes from four of five @entity1 became weaker and gradually approached normal levels. One @entity1 had @entity3794 and showed significant reduction in pulmonary functions but elevated reactivity of BAL lymphocytes to pigeon antigens. CONCLUSION: This follow-up study demonstrates persistence of sensitized lymphocytes and antibody production in the respiratory tract and warrants careful evaluation of @entity1 with @entity19998 , even after antigen avoidance.
