Surface marker expression of XXXX B-cell lymphomas.

@entity1 @entity72412 @entity26247 @entity5734 @entity48659 @entity26053 @entity1072 @entity3052 @entity16601 @entity48660 @entity1199 @entity2902
We have generated a battery of monoclonal antibodies (MAbs) that distinguish different antigen molecules present in @entity1 B cells. Two antigen systems, termed @entity16601 and @entity72412 , respectively, were expressed in most surface immunoglobulin-positive B cells and thus showed pan-B cell specificity. Two other antigens ( @entity26053 and @entity48659 ) appeared to be expressed mainly on small resting B cells but not on large activated B cells. In contrast with @entity26053 and @entity48659 , @entity48660 and L4, the latter of which corresponds to OKT10, were not or little expressed on resting B cells, but were found on these B cells after activation either in-vivo or in-vitro with staphylococcal protein-A (SAC) plus @entity1199 ( @entity1199 ) or with pokeweed mitogen (PWM). We also produced MAb ( @entity26247 ) that detected @entity2902 ( @entity2902 ) consistently expressed on in-vitro activated B cells as described above. In contrast with L4, @entity26247 and @entity48660 , @entity48659 was lost from in-vitro-activated B cells, following the appearance of either @entity26247 or @entity48660 on these in-vitro-activated B cells. Then, we analyzed antigen profiles of B cell tumors using these MAbs as described above. Common @entity3052 (CALL) expressed L4 and @entity48659 . @entity1072 ( @entity1072 ) and @entity5734 ( @entity5734 ) possessed most of the B cell antigens as described herein, and furthermore, @entity5734 expressed @entity2902 as detected by @entity26247 MAb. In the case of B cell lymphomas, they were phenotypically divided into two groups, corresponding to either early or late activated B cells.(ABSTRACT TRUNCATED AT 250 WORDS)
