Evaluation of XXXX irradiation in the treatment of experimental @entity157 .

@entity5 @entity786 @entity7283 @entity2101 @entity35 @entity157
A study evaluating the efficacy of @entity2101 ( @entity2101 ) as a treatment modality in experimental @entity157 is reported. @entity7283 (3924) 1 x 10(6) cells were transferred subcutaneously into 40 male ACI @entity35 (weight, 150 to 200 g). Animals were divided into four experimental groups: group 1 (n = 10) consisted of untreated controls; group 2 (n = 10) received intraperitoneal @entity786 50 mg/kg as a single dose; group 3 (n = 10) underwent @entity2101 only; and group 4 (n = 10) received both chemotherapy (as in group 2) and @entity2101 (as in group 3). @entity2101 was administered with a 5.5-cm diameter 4-MHz quartz transducer creating a continuous wave with 400 W/cm2 focal intensity. The entire @entity5 was irradiated in 1-mm increments (horizontal and vertical) using treatment cycles of 4 seconds on and 11 seconds off. Total body weight and @entity5 volume were measured on the day of treatment, and 4 weeks later. At 4 weeks, the animals were killed, the @entity5 was excised and weighed, and @entity5 volume was determined. @entity5 volume in all treated animals (groups 2, 3 and 4) was significantly smaller than in controls (P less than .001) at 4 weeks, and @entity5 volume for animals in group 4 was significantly smaller than for those in groups 2 and 3 (P less than .01). These data indicate that @entity2101 significantly reduces @entity5 size when compared with control @entity35 with @entity7283 . A synergistic effect of chemotherapy and @entity2101 was observed and resulted in an enhanced @entity5 response and reduction of @entity5 size.(ABSTRACT TRUNCATED AT 250 WORDS)
