XXXX premedication versus placebo in wisdom teeth extraction: a randomised controlled trial.

@entity1 @entity227 @entity566 @entity2493 @entity148 @entity158 @entity282 @entity34471
INTRODUCTION: @entity158 after wisdom teeth surgery can be moderate in severity and is compounded by preoperative @entity148 in young @entity1 . We studied the effect of @entity2493 premedication on @entity282 and preoperative @entity148 in @entity1 undergoing wisdom teeth extractions. METHODS: This randomised controlled trial recruited 76 @entity1 at Khoo @entity34471 Puat Hospital who were American Society of Anesthesiologists physical status I and II, aged 21 to 65 and scheduled to undergo elective extraction of all four wisdom teeth under general anaesthesia. @entity1 with a history of long-term use or @entity566 to @entity2493 were excluded. The @entity1 received either 6 mg @entity2493 or a placebo 90 minutes before surgery. Visual analogue scale (VAS) scores at multiple time intervals for @entity282 and preoperative @entity148 , @entity1 satisfaction and first-night sleep quality scores were obtained. Mixed-effects regression models were used for longitudinal analysis of @entity227 , @entity148 and satisfaction scores. RESULTS: Maximum VAS scores for @entity158 and @entity148 were 18.6    19.1 mm at 60 minutes postoperatively and 26.2    23.4 mm at 90 minutes preoperatively, respectively. After adjusting for gender, female @entity1 who received @entity2493 had a faster rate of reduction of @entity227 (p = 0.020) and @entity148 scores (p = 0.003) over time compared to the placebo group. No such effect was demonstrated in male @entity1 . There was no significant difference in sleep quality or satisfaction scores. CONCLUSION: @entity2493 use did not consistently contribute to @entity158 and @entity148 amelioration in all @entity1 . Our study demonstrated a positive effect in female @entity1 , suggestive of sexual dimorphism.
