Relevance of Blood-Brain Barrier Disruption After Endovascular Treatment of XXXX : Dual-Energy Computed Tomographic Study.

@entity1 @entity8 @entity932 @entity64 @entity548 @entity5748 @entity536 @entity385
BACKGROUND AND PURPOSE: Computed tomographic (CT) @entity536 ( @entity536 ) areas after endovascular therapy for acute @entity385 are a common finding indicative of blood-brain barrier disruption. @entity5748 allows an accurate differentiation between @entity536 areas related to @entity8 ( @entity8 ) or to @entity932 ( @entity932 ). We sought to evaluate the prognostic significance of the presence of @entity8 and @entity932 after endovascular therapy. METHODS: A prospective cohort of 132 @entity1 treated with endovascular therapy was analyzed. According to dual-energy CT findings, @entity1 were classified into 3 groups: no @entity536 areas (n=53), @entity8 (n=32), and @entity932 (n=47). The rate of new @entity548 transformations was recorded at follow-up neuroimaging. Clinical outcome was evaluated at 90 days with the modified Rankin Scale (poor outcome, 3-6). RESULTS: Poor outcome was associated with the presence of @entity8 (odds ratio [OR], 11.3; 95% confidence interval, 3.34-38.95) and @entity932 (OR, 10.4; 95% confidence interval, 3.42-31.68). The rate of poor outcome despite complete recanalization was also significantly higher in @entity8 (OR, 9.7; 95% confidence interval, 2.55-37.18) and @entity932 (OR, 15.1; 95% confidence interval, 3.85-59.35) groups, compared with the no- @entity536 group. @entity1 with @entity8 disclosed a higher incidence of delayed @entity548 transformation at follow-up (OR, 4.5; 95% confidence interval, 1.22-16.37) compared with no- @entity536 @entity1 . CONCLUSIONS: Blood-brain barrier disruption, defined as @entity8 and @entity932 on dual-energy CT, was associated with poor clinical outcomes in @entity1 with @entity64 treated with endovascular therapies. Moreover, isolated @entity8 was associated with delayed @entity548 transformation. These results support the clinical relevance of blood-brain barrier disruption in @entity64 .
