[Classification of XXXX based on a comparative analysis of contacts in DNA-protein complexes and specific DNA-protein interactions].

@entity535 @entity1522 @entity2036
The classification of @entity535 residues based on the events of contact formation between distinct @entity535 and selected @entity2036 was constructed. Thus, the most integral properties, that characterize interactions in organization of DNA-protein complexes, were used. We applied the Voronoi-Delaunay tessellation to draw statistics of contacts and area of contacts for the set included 1937 DNA-protein complexes. Similarities of @entity535 residues have been searched for based on the comparison of corresponded rows and matrixes of contacts and areas of contacts. Nine measures of distance were used for estimation of rows similarity degree. The procedure of clustering @entity1522 in groups included three hierarchical and two nonhierarchical methods. A total tree was built using nine techniques of estimating distance with three hierarchical clustering methods. It was shown that clustering centers in the main groups are always constant while other relationships between objects vary. Clustering of binary associations was found for the most @entity1522 . Major classes of up to six @entity1522 correspond to the certain local structures of the polypeptide chain in the context of @entity535 composition. These data should be taken into account when designing DNA-protein ligands.
