@entity4008 causes two distinct forms of cellular damage in the hippocampal dentate gyrus in @entity1 XXXX .

@entity1 @entity522 @entity4008 @entity16 @entity2260 @entity693 @entity4207 @entity35 @entity328 @entity528
@entity4008 causes @entity16 in up to 50% of survivors. Two pathogens known for their propensity to cause severe @entity16 are @entity328 and group B streptococci. Some forms of neuronal sequelae, such as @entity4207 , have been associated with @entity528 in the hippocampus. To learn more about hippocampal injury in @entity693 , we performed a comparative study in @entity4008 due to @entity2260 and group B @entity328 , in which 11-day-old @entity1 @entity35 were infected intracisternally with either of the two pathogens. Histopathological examination of the @entity528 in the dentate gyrus of the hippocampus showed that @entity2260 caused predominantly classical apoptotic cell death. Cells undergoing apoptosis were located only in the subgranular zone and stained positive for activated @entity522 and TUNEL. Furthermore, dividing progenitor cells seemed particularly sensitive to this form of cell death. Group B @entity328 was mainly responsible for a @entity522 -independent (and TUNEL-negative) form of cell death. Compared with the morphological features found in apoptosis (e.g., apoptotic bodies), this form of @entity528 was characterized by clusters of uniformly shrunken cells. It affected the dentate gyrus throughout the blade, showing no preferences for immature or mature neurons. Thus, depending on the infecting agent, @entity4008 causes two distinct forms of cell injury in the dentate gyrus.
