Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous @entity692 . A XXXX study.

@entity692 @entity23012 @entity235
PURPOSE: Bone regeneration stimulated by two different shapes of interconnected porous @entity692 (IP- @entity23012 ) granules was evaluated in the mandibles of 3 @entity235 . METHODS: Deferent shapes of IP- @entity23012 were used, spherical (spherical shaped IP- @entity23012 granules) and irregular shapes (irregularly shaped IP- @entity23012 granules). Two bone sockets (3mm in diameter and 5mm in depth) were prepared in the right edentulous mandible of each animal where right premolars had been extracted and sites healed for 3 months. The two types of IP- @entity23012 were filled into the sockets to stimulate bone regeneration. New bone formation was evaluated histologically at 4, 8 and 12 weeks after filling. RESULTS: At 4 weeks, little bone formation was apparent in any of the bony sockets. At 8 weeks, newly formed bone was detected between the granules but not in the pores. In contrast, at 12 weeks, bone formation was clearly observed not only between the granules but also inside the granule pores. Comparing the two sites at 8 and 12 weeks, more bone formation was detected in sites receiving irregularly shaped IP- @entity23012 than in sites receiving spherical IP- @entity23012 . CONCLUSION: These results indicate that use of irregularly shaped IP- @entity23012 may enhance bone regeneration. The results of this preliminary study suggest that irregularly shaped IP- @entity23012 granules may have more possible usefulness than spherically shaped granules as a scaffold for bone regeneration.
