[Expression of vascular endothelial growth factor and its receptor ( XXXX ) in @entity0 ].

@entity8034 @entity0 @entity7 @entity5 @entity3 @entity6758
OBJECTIVE: To investigate the expression of vascular endothelial cell growth factor ( @entity7 ) and its receptor ( @entity6758 ) in @entity0 and the relationship of such expression with angiogenesis, @entity5 invasion and @entity3 . METHODS: In situ hybridization and immunohistochemistry technique were used to test the expression of mRNA and protein expression of @entity7 and @entity6758 in 48 specimens of @entity0 . 48 specimens of tissues near @entity5 , 3 specimens of @entity0 , and 3 specimens of normal breast were used as controls. RESULTS: @entity7 mRNA and its protein were expressed highly in @entity0 cells with the positive rate of 75% and 70.8% respectively. There was almost no expression of @entity7 in vascular endothelial cells. @entity6758 mRNA and its protein were expressed only in a small quantity in a few @entity5 cells. The amount of blood vessel positive in @entity8034 mRNA and its protein was (26 +/- 12) piece/0.72 mm(2) and (24 +/- 12) piece/0.72 mm(2) respectively. The microvascular density (MVD) was significantly greater in @entity7 and @entity6758 higher expression groups than in lower groups (P < 0.01). Both @entity7 expression and @entity6758 expression were well correlated with the histological grade and lymph node @entity3 . CONCLUSION: @entity7 promotes angiogenesis by paracrining in @entity0 , and takes part in @entity5 invasion and lymph node @entity3 . Test of the expression of @entity7 and @entity6758 may act as a reliable index to determine angiogenesis, @entity5 , invasion and @entity3 . Blocking their secretion and effect may act as a new treatment for @entity0 .
