Endothelial XXXX -reperfusion injury in @entity1 : association with age and habitual exercise.

@entity1 @entity32 @entity308 @entity63 @entity384 @entity409 @entity453
Advancing age is a major risk factor for @entity453 . @entity409 accompanied by increased oxidative stress and @entity32 with aging may predispose older arteries to greater @entity63 -reperfusion (I/R) injury. Because coronary @entity63 cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in @entity1 . Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery @entity384 ( @entity384 ), was measured before and after 20 min of continuous forearm occlusion in young sedentary (n = 10, 24    2 yr) and middle-aged (n = 9, 48    2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young (n = 9, 25    1 yr) and middle-aged endurance-trained (n = 9, 50    2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after @entity63 , @entity384 decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. @entity384 returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained @entity308 in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and @entity32 were not related to @entity384 . In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in @entity1 . Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.
