Lesions in the liver and kidney of Dirofilaria immitis-infected XXXX following treatment with ivermectin.

@entity3070 @entity8 @entity738 @entity235 @entity5476
Six @entity235 with spontaneous @entity5476 were injected with a single dose of @entity3070 . After 48 h of treatment, microfilariae counts were reduced by 92%-98% of pretreatment counts. In pretreatment biopsies examined by light and electron microscopy, microfilariae were unaltered in the sinusoids of the liver and also in the glomerular capillaries and interstitial blood vessels of the kidney. However, there was irregular thickening and dense deposits in the basement membranes of glomerular capillaries, along with a modest increase in mesangial cells and matrix. In post-treatment liver biopsies examined by light microscopy, there were numerous @entity738 in the sinusoids which contained degenerated microfilariae. In post-treatment kidney biopsies there was moderate thickening of glomerular basement membranes along with pronounced proliferation of mesangial cells and matrix. @entity8 were partially or completely occluded by degenerated microfilariae. In addition, there were interstitial @entity738 in the kidney. It was observed with the aid of electron microscopy that highly vacuolated and degenerated microfilariae were incorporated into @entity738 in the liver sinusoids of post-treatment biopsies. In post-treatment kidney biopsies glomerular capillaries were usually occluded by degenerated microfilariae. Basement membranes were thickened and contained dense deposits. Mesangial cells and matrix were extensively increased. Interstitial @entity738 in the kidney contained dead microfilariae.
