Change in XXXX -related disability in a population-based cohort: a 10-year follow-up study.

@entity1 @entity717 @entity15 @entity66
OBJECTIVE: S: To study the change in disability over 10 years in individual @entity1 constituting the 1991 Olmsted County, MN, @entity15 ( @entity15 ) prevalence cohort. METHODS: The authors reassessed this 1991 cohort in 2001. The authors determined the @entity717 ( @entity717 ) for each @entity1 still alive, and within the year prior to death for those who died. The authors analyzed determinants of potential prognostic significance on change in disability. RESULTS: Follow-up information was available for 161 of 162 @entity1 in the 1991 cohort. Only 15% had received immunomodulatory therapy. The mean change in @entity717 for the entire cohort over 10 years was 1 point and 20% worsened by >or=2 points. For @entity1 with @entity717 <3 in 1991 (n = 66), 83% were ambulatory without a cane 10 years later. For @entity1 with @entity717 of 3 through 5 in 1991 (n = 33), 51% required a cane to ambulate (48%) or worse (3%). For @entity1 with @entity717 6 to 7 in 1991 (n = 39), 51% required a wheelchair or worse in 2001. Gait impairment at onset, @entity66 were associated with more worsening of disability (p < 0.002). The 10-year survival was decreased compared with the Minnesota white population for both @entity1 and @entity1 . CONCLUSIONS: Although survival was reduced and 30% of @entity1 progressed to needing a cane or wheelchair or worse over the 10-year follow-up period, most remained stable or minimally progressed. @entity1 within the @entity717 3.0 through 5.0 range are at moderate risk of developing important gait limitations over the 10-year period. The authors did not identify factors strongly predictive of worsening disability in this study.
