Inhibition of epithelial-mesenchymal transition in @entity150 cells via modulation of XXXX signalling.

@entity7242 @entity72563 @entity4245 @entity14685 @entity5 @entity3546 @entity3470 @entity150 @entity19099 @entity1435 @entity9623 @entity1366 @entity6076
UNASSIGNED: Mounting evidence suggests that signalling cross-talk plays a significant role in the regulation of epithelial-mesenchymal transition (EMT) in @entity5 cells. However, the complex network regulating the EMT in different @entity5 types has not been fully described yet which affects the development of novel therapeutic strategies. In the present study, we investigated the signalling pathways involved in EMT of @entity150 cells and demonstrated the effects of two novel agents in the regulation of EMT. @entity72563 ( @entity9623 ) and @entity14685 (TQ) have been shown to possess anti- @entity5 properties. However, their targets in the regulation of @entity5 cell behavior are not well defined. Here, we defined the effects of two putative anti- @entity5 agents on @entity150 cell migration and their possible intracellular targets in the regulation of EMT. Our results suggest that @entity9623 or TQ treatment affected @entity6076 , @entity4245 , @entity19099 , and @entity3546 expressions and effectively attenuated @entity3470 activity. The downstream components in @entity3470 signalling were also affected. @entity9623 treatment resulted in the concomitant inhibition of extracellular matrix-regulated protein kinases 1 and 2 ( @entity1366 ), @entity1435 (MAPK) and @entity7242 activity. On the other hand, TQ treatment increased @entity7242 activity while exerting no effect on @entity1366 or p38 MAPK activity. Given the stronger inhibition of EMT-related markers in @entity9623 -treated samples, we concluded that this effect might be due to collective inhibition of multiple signalling pathways which result in a decrease in their cross-talk in @entity150 cells. Overall, the data in this study proposes novel action mechanisms for @entity9623 or TQ in @entity150 cells and highlights the potential use of these active compounds in the regulation of EMT.
