Effects of XXXX and reperfusion injury on long-term graft function.

@entity1 @entity500 @entity10297 @entity63
BACKGROUND: The clinical manifestation of @entity63 /reperfusion injury in renal transplantation is @entity10297 ( @entity10297 ), which is associated with an increase in acute rejection episodes (ARE), costs, and difficulties in immunosuppressive management. We sought to evaluated the @entity10297 impact after renal transplant. METHODS: We evaluated a group of 628 @entity1 undergoing deceased donor renal transplantation between 2002 and 2005 at 3 Brazilians institutions to define the main @entity10297 characteristics. RESULTS: @entity10297 incidence was 56.8%, being associated with elderly donors (P = .02), longer time on dialysis (P = .001), and greater @entity63 ( @entity63 ; P = .001). Upon multivariate analysis, time on dialysis >5 years increased @entity10297 risk by 42% (P = .02) and @entity63 >24 hours increased it by 57% (P = .008). In contrast, @entity10297 was associated with an higher incidence of ARE: 27.7% in @entity10297 versus 18.4% in IGF @entity1 (P = .047). The ARE risk was 46% higher among individuals with @entity10297 (P = .02), 44% among @entity1 >45 years old (P < .001), 50% among those with >5 years of dialysis time (P = .02), and 47% lower among the who were prescribed mycophenolate instead of @entity500 (P < .001). @entity1 with @entity10297 showed worse 1-year graft function (54.6    20.3 vs 59.6    19.4 mL/min; P = .004), particularly those with ARE (55.5    19.3 vs 60.7    20.4; P = .009). One-year graft survival was 88.5% among @entity10297 versus 94.0% among non- @entity10297 @entity1 . CONCLUSION: The high incidence of @entity10297 was mainly associated with a prolonged @entity63 . There was a relationship between @entity10297 and ARE, as well as with a negative influence on long-term graft function.
