The effect of three hypolipidemic drugs on @entity12609 activity and peroxisomal and mitochondrial XXXX oxidation in @entity35 cardiac and skeletal muscle.

@entity12880 @entity2365 @entity1735 @entity17544 @entity12609 @entity35 @entity413 @entity24565
@entity12609 activity and peroxisomal and mitochondrial @entity2365 oxidation have been investigated in cardiac and skeletal muscle from @entity35 fed @entity12880 , @entity17544 or @entity24565 in an unrefined diet for different periods of time. @entity24565 was also added to either a high @entity1735 (70% of kilocalories from @entity413 ) or high fat (70% of kilocalories from lard) diet and fed to @entity35 for either 1 or 3 weeks. @entity12609 activity was elevated in all muscles from @entity35 fed the hypolipidemic drugs. The response of @entity12609 activity in muscle to clofibrate was dose-dependent. The response time of @entity12609 activity was different in individual muscles. Peroxisomal @entity2365 oxidation was elevated in the heart and soleus muscle from @entity35 fed @entity24565 in either the high- @entity1735 or the high-fat diet. There was no change in peroxisomal @entity2365 oxidation in psoas or extensor digitorum longus muscle from @entity35 fed the drugs. Mitochondrial @entity2365 oxidation was only slightly increased by @entity24565 in the heart and soleus muscles after 3 weeks of @entity24565 feeding. The results suggest that the cardiac muscle, like the liver, responds to hypolipidemic drug treatment with an increase in peroxisomal fat oxidation. The skeletal muscle response is less specific and that tissue may not contribute to the hypolipidemic effect of the drugs. The findings also suggest that these drugs do not induce peroxisome proliferation in skeletal muscle.
