Leukocyte protein calprotectin and outcome in XXXX . A longitudinal study.

@entity1 @entity32 @entity1190 @entity283 @entity309 @entity1851
OBJECTIVE: To determine if calprotectin is predictive for outcome in @entity1 with @entity309 ( @entity309 ). METHODS: Fifty six @entity309 in- @entity1 with variable disease duration were prospectively followed for five years. Clinical and laboratory data were collected to assess disease activity. @entity283 ( @entity283 ) and radiographic scores (of hands and wrists) as described by Larsen were used as outcome measures. Plasma calprotectin levels were determined with ELISA technique. RESULTS: Significant correlations (r) were found cross-sectionally at follow-up between @entity1190 concentration and other known parameters of disease activity and severity: @entity1851 (r = 0.67). investigator's global assessment of disease activity (r = 0.57). Waaler titre (r = 0.50). @entity283 score (r = 0.48) and number of swollen joints (r = 0.48). Calprotectin at baseline was not identified as an independent predictor for @entity283 or radiographic progression in the multivariate analysis. CONCLUSION: The results confirm calprotectin as a good measure of disease activity and @entity32 in @entity309 . However, the level of calprotectin at baseline was not predictive for radiographic damage or functional impairment five years later.
