Pretreatment with alpha XXXX enhances neurologic recovery after experimental spinal cord compression injury.

@entity468 @entity4793 @entity1566 @entity1813 @entity912 @entity130
Lipid hydrolysis with subsequent production of @entity1813 and lipid peroxidation are two of the earliest potentially pathochemical events induced in spinal cord tissue by mechanical @entity130 . Although these membrane lipid disturbances are thought to contribute to the @entity912 that occur subsequent to @entity1566 , such a correlation has not been demonstrated directly. Consequently, the purpose of this study was to test the capacity of alpha @entity4793 , the major lipid antioxidant in cellular membranes and a compound that limits the injury-induced lipid hydrolysis and peroxidation in spinal cord tissue, to promote functional recovery in a static loading model of @entity1566 . After laminectomy, the L2 spinal cord of @entity468 was compressed with 180 g for 5 min. For 5 days before injury and for 5 days postinjury, treated @entity468 received orally 1000 IUD-alpha @entity4793 daily. Control @entity468 were similarly injured but untreated. All @entity468 were blindly evaluated weekly for 4 weeks for their neurologic recovery based on an 11 point behavioral scale that assessed walking, running, and stair climbing. By the second postinjury week, alpha @entity4793 -pretreated @entity468 demonstrated significantly better recovery than untreated controls. By 4 weeks, treated @entity468 had recovered 72% of their preinjury function as compared with 20% for untreated controls, i.e., a 3.5-fold difference. These results strongly suggest that lipid peroxidation and/or hydrolysis is primarily involved in the genesis of posttraumatic @entity912 and that alpha @entity4793 exerts its protection of injured spinal cord tissue, at least in part, by its antioxidant and/or antilipolytic activity.
