Adjuvant drug strategies in the treatment of recurrent XXXX .

@entity1 @entity410 @entity66 @entity1724 @entity1185 @entity10211 @entity1499 @entity14584
The purpose of this study was to evaluate adjuvant drug therapies combined with standard laser excision in the treatment of recurrent @entity1724 . Previous studies have presented conflicting data on the efficacy of various treatments, including interferon and @entity10211 . A retrospective study of 34 @entity1 with moderate to severe @entity1185 who underwent both laser surgery and adjuvant therapy was therefore performed. All @entity1 were treated with interferon. Five interferon failures received @entity10211 , and three with recalcitrant disease received @entity1499 . @entity14584 produced a complete response in 16 @entity1 and partial response in 12 @entity1 . @entity66 had a slightly higher response to interferon than adult-onset disease. @entity10211 produced no response in all five @entity1 . @entity1499 demonstrated a marked improvement in both severity of disease and treatment interval in all three @entity1 . Serious side effects were limited to one interferon @entity1 with @entity410 , which resolved with discontinuation of therapy. We conclude that adjuvant therapy including interferon and @entity1499 is clearly of benefit in the treatment of @entity1 with @entity1724 . A detailed approach to surgery combined with an interferon dosing regimen is presented. Further study of @entity1499 appears warranted.
