Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical @entity1468 and XXXX .

@entity1 @entity5493 @entity101 @entity1423 @entity519 @entity1468 @entity2142 @entity2431
Overexpression of soluble vascular endothelial growth factor receptor-1 has been linked to @entity1468 and is thought to be secondary to @entity2431 caused by @entity519 . Villous hypermaturity, characterized by presence of increased syncytial knots, has been associated with syndromes of @entity2431 , particularly when severe. This study was undertaken to determine whether there is a link between soluble vascular endothelial growth factor receptor-1 expression, @entity5493 , and clinical severity of @entity1468 . We conducted a retrospective cohort study in which 48 placentas were selected from pathology archives ( @entity101 group). Of these, 6 had chronic @entity101 , 15 had mild @entity1468 , 14 had severe @entity1468 , and 13 had @entity2142 , elevated liver enzymes, and @entity1423 . These were compared with 55 placentas from normotensive @entity1 (control group). One representative section of placental parenchyma from each case was stained with an antibody to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 and given a score based on extent and intensity of staining, representing expression level. Assignment of staining score was done, blinded to clinical history and pathologic diagnosis. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining was seen in placental syncytiotrophoblasts and was particularly strong in syncytial knots. There was a positive association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining score and severity of clinical @entity101 state, small placental size, and @entity5493 . The association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 score and small placentas did not persist after controlling for hypermaturity. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 overexpression in the placenta strongly correlates with both severity of @entity101 and @entity5493 . The correlation with @entity5493 further links @entity519 to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 production in the placenta.
