Evaluation of the relation between interstitial cells of cajal (CD117) and serotonin receptor ( XXXX ) with postfundoplication @entity1282 .

@entity35 @entity5376 @entity1282
UNASSIGNED: Objective: The aim of the present study is to investigate the effect of Nissen fundoplication to the pacemaker cells of an intestinal system and the serotonin receptors on an ICC membrane. Methods: Sixteen adult male @entity35 were taken into study. @entity35 were divided in to the following two groups. Nissen fundoplication was performed to study group (Group 1) and no surgical procedures were applied to control group (group 2). The @entity35 who were subjected to surgery and the @entity35 without surgery were sacrificed on to postoperative 14 days. Specimens for the pathologic analysis were obtained from upper esophagus (group A) and esophagogastric junction (EGJ) (group B). Distribution of ICC and @entity5376 were evaluated separately. Results: There was a significant difference (p  =  0.01, p  =  0.02, respectively) regarding number of cells stained with CD117 between the group 1B-2B and group 2A-2B. Also there was a significant difference between (p  =  0.01, p  =  0.01 respectively) number of cells stained with @entity5376 in groups 1A-1B and 2A-2B. However, no correlation was detected between group 1B-2B for @entity5376 . Conclusion: A reduction in the number of ICC was observed in esophagogastric junctions of the fundoplication group but @entity5376 distribution did not show a significant difference. A decrease in the number of ICC may be effective at postfundoplication @entity1282 .
