The impairment in daily life of XXXX haemophiliacs.

@entity1 @entity2801 @entity571 @entity548 @entity28 @entity447 @entity353
Obesity is a major health concern not only in the general population but also in @entity1 with @entity447 . Little is known about the consequences of @entity28 for @entity447 @entity1 . As @entity28 is an important risk factor for @entity571 , these effects may be even more pronounced in @entity447 @entity1 who are prone to joint damage. The association between @entity28 and limitations in daily activities as well as the frequency of @entity548 and use of @entity2801 ( @entity2801 ) concentrate in @entity28 and normal weight @entity447 @entity1 was assessed. Fifteen @entity28 (BMI >=  30 kg m(-2)) and fifteen normal weight (BMI  <= 25 kg m(-2)) @entity447 @entity1 matched for severity and age were analysed. The @entity447 ( @entity447 ) was used to assess the impairment in daily activities. Compared with the normal weight @entity447 @entity1 , @entity28 haemophiliacs had a significantly lower sum score (88/100 and 98/100, respectively, P = 0.02), which was mainly caused by an impaired lower limb function. All other components of the @entity447 also showed lower scores in the @entity28 @entity1 , but did not reach statistical significance. @entity548 requiring treatment with @entity2801 concentrate occurred in the @entity28 haemophiliacs (17 @entity548 in eight individuals) compared with the controls (three @entity548 in three individuals) (P = 0.045). Compared with non- @entity28 @entity447 @entity1 , @entity28 haemophiliacs had @entity548 and a lower overall @entity447 score, which was driven by a lower limb function score. Prevention of overweight and @entity353 requires special attention from physicians treating @entity447 @entity1 .
