Diagnostic value of hyperfibrinogenemia as a predictive factor for appendiceal perforation in XXXX .

@entity1 @entity32 @entity2002 @entity697 @entity698
BACKGROUND: @entity697 is one of the most common emergency requiring operation. As the first discovered coagulation factor, plasma @entity2002 frequently increases with @entity32 due to the activation of coagulation. The aim of this retrospective study was to investigate the diagnostic value of hyperfibrinogenemia as a preoperative laboratory marker for appendiceal perforation in @entity1 with @entity697 . MATERIALS AND METHODS: We identified 455 @entity1 (202 females, 253 males; mean age, 31.7 years) with histologically confirmed @entity697 who underwent laparoscopic or open appendectomy. Results of preoperative laboratory values and post-operative histologic results were analysed retrospectively. A multivariate logistic regression model was performed to determine @entity1 's age and laboratory tests associated with @entity698 . RESULT: Mean plasma @entity2002 level of all @entity1 was 3.99   g/L (1.41 SD; range, 1.73-10.6   g/L; median, 3.69   g/L). @entity1 with appendiceal perforation had a mean @entity2002 level of 5.72   g/L (1.52 SD; range, 3.38-10.04   g/L; median, 5.28   g/L), which was significantly higher than those with nonperforated groups (P = 0.001). Multivariate analysis showed @entity2002 and D-dimer were associated with perforation (P = 0.001, P = 0.014, respectively). Areas under the receiver operating characteristic curve of @entity2002 for discriminating @entity698 from non-perforated groups were larger than white blood cell and D-dimer. CONCLUSIONS: Hyperfibrinogenemia was common in @entity1 with @entity697 and @entity2002 may be useful as a predictive factor for appendiceal perforation.
