Use of endoscopic distal attachment cap to enhance image stabilization in probe-based confocal laser endomicroscopy in XXXX .

@entity1 @entity1127 @entity14 @entity652 @entity1586
BACKGROUND AND STUDY AIMS: @entity14 can be prevented through the use of colonoscopy with polypectomy. Most @entity1586 are benign or low grade @entity652 . However, currently all lesions need histopathologic analysis, which increases diagnostic costs and delays the final diagnosis. Confocal laser endomicroscopy (CLE) is a new technology that enables real-time endomicroscopy. However, there are challenges to maintaining a stable image with currently available systems. We conducted a small study to obtain a preliminary assessment of whether the use of an endoscopic distal attachment cap may enhance image quality of CLE in comparison with images obtained with free-hand acquisition. @entity1 AND METHODS: Forty outpatients underwent colonoscopy for evaluation of @entity1586 in a single academic medical center. @entity1 were assigned randomly to 1 of 2 study arms on the basis of whether an endoscopic distal attachment cap was used (n=21, Cap Used) or not used (n=19, No Cap) in the procedure. The quality of confocal images and probe stabilization was summarized. RESULTS: A total of 81 @entity1127 were identified. The proportion of @entity1127 with images of high quality was 74% (28/38) in the Cap Used group and 79% (30/38) in the No Cap arm. Image stability was also similar with and without a cap.Diagnostic accuracy was estimated to be slightly higher in the Cap Used group for probe-based confocal laser endomicroscopy (pCLE; 78% vs 70%). This was also true for white-light and narrow-band imaging. CONCLUSIONS: This preliminary study did not yield any evidence to support that the use of an endoscopic distal attachment cap improves the quality of images obtained during CLE.
