Cost-Utility Analyses of XXXX Surgery in Advanced Age-Related @entity1020 .

@entity1 @entity1020 @entity231
PURPOSE: To explore the cost-utility of @entity231 surgery in @entity1 with advanced @entity1020 ( @entity1020 ). METHODS: @entity1 who were diagnosed as having and treated for age-related @entity231 and with a history of advanced @entity1020 at the Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, were included in the study. All of the @entity1 underwent successful phacoemulsification with foldable posterior chamber intraocular lens implantation under retrobulbar anesthesia. Best-corrected visual acuity (BCVA) and utility value elicited by time trade-off method from @entity1 at 3-month postoperative time were compared with those before surgery. Quality-adjusted life years (QALYs) gained in a lifetime were calculated at a 3% annual discounted rate. Costs per QALY gained were calculated using the bootstrap method, and probabilities of being cost-effective were presented using a cost-effectiveness acceptability curve. Sensitivity analyses were performed to test the robustness of the results. RESULTS: Mean logarithm of the minimum angle of resolution BCVA in the operated eye increased from 1.37    0.5 (Snellen, 20/469) to 0.98    0.25 (Snellen, 20/191) (p < 0.001); BCVA in the weighted average from both eyes (=75% better eye + 25% worse eye) was changed from 1.13    0.22 (Snellen, 20/270) to 0.96    0.17 (Snellen, 20/182) (p < 0.001). Utility values from both @entity1 and doctors increased significantly after surgery (p < 0.001 and p = 0.007). @entity1 gained 1.17 QALYs by @entity231 surgery in their lifetime. The cost per QALY was 8835 Chinese yuan (CNY) (1400 U.S. dollars [USD]). It is cost-effective at the threshold of 115,062 CNY (18,235 USD) per QALY in China recommended by the World Health Organization. The cost per QALY varied from 7045 CNY (1116 USD) to 94,178 CNY (14,925 USD) in sensitivity analyses. CONCLUSIONS: Visual acuity and quality of life assessed by utility value improved significantly after surgery. @entity231 surgery was a cost-effective intervention for @entity1 with coexistent @entity1020 .
