PKCgamma in Vc and XXXX is involved in trigeminal @entity9 .

@entity1931 @entity7198 @entity668 @entity128 @entity72766 @entity35 @entity9
The aim of the present study was to clarify the involvement of protein kinase Cy (PKCy) in the facial @entity9 following @entity128 . We analyzed the change in PKCy expression in the trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord ( @entity72766 ) following chronic @entity128 (ION-CCI). We also studied ION-CCI-mediated mechanical nocifensive behavior in @entity35 . The mechanical head-withdrawal threshold significantly decreased 1 to 14 days after ION-CCI compared with that before ION-CCI and in sham @entity35 . The expression of PKCy was significantly larger in the ipsilateral Vc compared with the contralateral side in ION-CCI @entity35 3, 7, and 14 days after ION-CCI. Intrathecal (i.t.) administration of the PKCy inhibitor @entity668 prevented an increase in the PKCy expression in the ipsilateral Vc. Moreover, i.t. administration of @entity668 annulled ION-CCI-mediated reduction in the head-withdrawal threshold. Taken together, these findings suggest that PKCy expression in the Vc played an important role in the mechanism of orofacial static mechanical @entity1931 following @entity7198 .
