Age-related outcomes following intracranial XXXX treatment with the Pipeline Embolization Device: a subgroup analysis of the IntrePED registry.

@entity1 @entity129 @entity932 @entity438 @entity16 @entity2791 @entity439 @entity397 @entity385
UNASSIGNED: OBJECT The association between age and outcomes following @entity439 treatment with flow diverters such as the Pipeline Embolization Device (PED) have not been well established. Using the International Retrospective Study of the Pipeline Embolization Device (IntrePED) registry, the authors assessed the age-related clinical outcomes of @entity1 undergoing @entity439 with the PED. METHODS @entity1 with @entity439 in the IntrePED registry were divided into 4 age groups:  <= 50, 51-60, 61-70, and > 70 years old. The rates of the following postoperative complications were compared between age groups using chi-square tests: spontaneous @entity397 , @entity932 ( @entity932 ), @entity385 , parent @entity2791 , @entity129 , @entity16 , @entity16 , combined @entity16 and mortality, and all-cause mortality. The association between age and these complications was tested in a multivariate logistic regression analysis adjusted for sex, number of PEDs, and @entity439 size, location, and type. RESULTS Seven hundred eleven @entity1 with 820 @entity439 were included in this study. Univariate analysis demonstrated no significant difference in @entity932 rates across age groups (lowest 1.0% for @entity1  <= 50 years old and highest 5.0% for @entity1 > 70 years old, p = 0.097). There was no difference in @entity385 rates (lowest 3.6% for @entity1  <= 50 years old and highest 6.0% for @entity1 50-60 years old, p = 0.73). Age > 70 years old was associated with higher rates of @entity16 ; @entity1 > 70 years old had @entity16 rates of 7.4% compared with 3.3% for @entity1 61-70 years old, 2.7% for @entity1 51-60 years old, and 0.5% for @entity1  <= 50 years old (p = 0.006). On multivariate logistic regression analysis, increasing age was associated with higher odds of combined @entity16 and mortality (odds ratio 1.02, 95% confidence interval 1.00-1.05; p = 0.03). CONCLUSIONS Increasing age is associated with higher @entity16 and mortality after Pipeline embolization of @entity438 . However, the overall complication rates of PED treatment in this group of highly selected elderly @entity1 (> 70 years) were acceptably low, suggesting that age alone should not be considered an exclusion criterion when considering treatment of @entity438 with the PED.
