Expression of @entity6333 in acquired XXXX @entity8 .

@entity3441 @entity1 @entity8 @entity644 @entity1987 @entity6333 @entity1988 @entity1985 @entity631
BACKGROUND: @entity6333 is a recently identified protein, which is synthesized in the podocytes and localized in the slit diaphragm area. @entity6333 is a cell adhesion molecule of the immunoglobulin superfamily, and presumably is a part of the zipper-like structure of the slit membrane. As the mutation of the gene coding @entity6333 induces @entity3441 of Finnish type, which is a prototype of @entity1985 , it has been suggested that @entity6333 also plays a role in acquired @entity8 . METHODS: To address the above issue, the expression of @entity6333 in acquired @entity1 @entity8 was studied by immunoelectron microscopy employing a polyclonal antibody against @entity6333 . Four normal @entity1 kidneys from nephrectomy specimens and eight kidney biopsy specimens from @entity8 @entity1 (one @entity1987 , one @entity631 ( @entity631 ), one membranoproliferative @entity631 , four @entity8 , and one @entity1988 ) were studied. @entity644 of the @entity1 ranged from 448 to 11725 mg/day. Effacement of the foot processes was observed in all @entity1 . RESULTS: The study demonstrated that the number and distribution of gold particles in the glomerular region, where the podocyte foot process was well preserved, were similar to that found in normal kidneys; however, gold particles were almost always absent in regions where the foot processes were effaced. The number of gold particles per foot process interspace was not different between normal controls and @entity631 @entity1 ; however, the number of gold particles per defined length (1000 nm) of the glomerular basement membrane underlying the foot processes was significantly reduced in @entity631 @entity1 . CONCLUSION: Using immunoelectron microscopy, we observed that the expression of @entity6333 in @entity631 was lower in regions where the foot processes were effaced, and comparable with that of normal controls where the foot process interspaces were preserved. The significance of our observation in the context of @entity644 in acquired @entity631 needs further clarification.
