Demographic and XXXX biomarker data as predictors of early recurrences of idiopathic @entity2106 .

@entity1 @entity229 @entity2105 @entity205 @entity880 @entity2106
OBJECTIVE: Approximately 40% of idiopathic @entity2106 ( @entity2106 ) @entity1 will suffer an exacerbation (recurrence of @entity2106 within 30 d after their last plasma exchange (PE) procedure), but there are no data to predict who is at greater risk. We studied the clinical utility of demographic and @entity2105 biomarker data to predict the risk for exacerbation. @entity1 : Forty-four acute episodes of idiopathic @entity2106 from 26 @entity1 were studied. METHODS: PE was performed plus either @entity229 (1 mg/kg/d) or @entity205 (2-3 mg/kg/d) as adjuncts. PE was continued daily until response (platelet count >150 000/microL and normalized @entity880 dehydrogenase) and tapered uniformly in all @entity1 . @entity2105 biomarkers were studied prior to PE and after achieving a response, but within 7 d of the last PE. RESULTS: African American race (AA) was associated with an increased risk for exacerbation (P = 0.046). @entity2105 at presentation was also significantly lower in @entity1 experiencing an exacerbation (P = 0.0364). After adjusting for the race effect, @entity2105 remained marginally significant (P = 0.0569). CONCLUSIONS: AA is significantly associated with an increased risk for exacerbations of @entity2106 . These data also suggest that decreasing pretreatment @entity2105 activity was associated with an increased risk for exacerbation, even after accounting for the effect of race.
