Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of XXXX (MESA).

@entity1 @entity353 @entity6 @entity101 @entity28 @entity731
AIMS: Impact of @entity353 on cardiac structure has not been extensively investigated in large, multi-ethnic, community-based populations. We investigated the longitudinal impact of @entity353 on cardiac structure by cardiac magnetic resonance (CMR). METHODS AND RESULTS: 2351 @entity1 in the Multi-Ethnic Study of @entity731 (MESA) who underwent CMR at Exam 1 (2002) and Exam 5 (2011) were included. Primary outcomes were percentage change in LV mass (indexed to height) and LV mass-to-volume ratio (concentric LV remodelling). Multivariable linear regression was used to measure the association between outcomes and weight change. At median 9.4 years' follow-up, 639 individuals (27%) experienced >5% @entity353 (median 6.9   kg) and 511 (22%) had >5% weight gain (median 6.4   kg). A >5% weight gain was associated with the greatest increase in LV mass (+5.4% median) and LV mass-to-volume ratio (+12.2% median). Adjusting for medications, @entity101 / @entity6 (and change in these risk factors), age, race and other risk factors, every 5% @entity353 was associated with a 1.3% decrease in height-indexed LV mass and 1.3% decrease in LV mass-to-volume ratio (p<0.0001). There was no effect modification/confounding by age, race, gender or baseline BMI. Change in LV mass-to-volume ratio was roughly linear, specifically for modest degrees of @entity353 (-10% to +10%). Change in LV mass was linear with @entity353 , suggesting no threshold of @entity353 is needed for LV mass regression. CONCLUSIONS: In a large multi-ethnic population, @entity353 is associated with beneficial effects on cardiac structure, independent of age, race, gender, BMI and @entity28 -related cardiometabolic risk. There is no threshold of @entity353 required to produce these effects.
