[Studies on multiple mucosal biopsy in @entity1 with bladder cancer. 2. Evaluation on the relationship between the results of multiple mucosal biopsy and recurrence, and the clinical course of cases with @entity189 in situ and micro-invasion of XXXX in situ].

@entity5 @entity1 @entity189
The predictive value of grade, number of @entity5 and histology of mucosal biopsy for @entity5 recurrence, the course of @entity189 in situ were examined. The Kaplan-Meier's method was used for the estimation of the recurrence-free rate in the @entity1 who had undergone transurethral resection (TUR) and the logrank test for testing the significance of difference in recurrence-free rate. The 5-year recurrence-free rate was 32.2%. The recurrence-free rate was 51.0% after 40 months postoperatively in @entity1 with a @entity5 , 12.8% after 42 months postoperatively in those with @entity5 . The @entity1 with a @entity5 had a significantly higher recurrence-free rate than those with @entity5 (P less than 0.001). The recurrence-free rate was analyzed according to the grade of main @entity5 , but significantly difference was not present. The recurrence-free rate was 44.4% after 42 months postoperatively in @entity1 with normal histology of mucosal biopsy and 9.5% after 34 months postoperatively in those with abnormal histology. The @entity1 showing normal histology in mucosal biopsy had a significantly higher recurrence-free rate than those with abnormal findings (P less than 0.001). the recurrence-free rate at the same area of biopsy site was analyzed according to the histologies of 537 mucosal biopsies. The recurrence-free rate was 76.7% after 42 months post operatively in areas with a normal biopsy, 44.3% after 35 months postoperatively in those with abnormal histology and the difference was statistically significant (P less than 0.001). Of the 15 @entity1 found to have @entity189 in situ, 4 were @entity189 in situ, 6 were associated with superficial @entity5 and 5 were associated with invasive @entity5 . Thirteen of the 15 @entity1 were alive and free of disease 18 to 42 months later. Two @entity1 associated with invasive @entity5 died 5 and 18 months after transcatheter embolization of internal iliac arteries. Of the 13 @entity1 who were found to have microinvasion of @entity189 in situ, 4 were not associated with visible @entity5 , 6 were associated with superficial @entity5 and 3 were associated with invasive @entity5 . Nine of the 13 @entity1 are alive and free of disease 7 to 53 months later. A @entity1 without any visible @entity5 who was treated with TUR and intravesical chemotherapy died and three @entity1 with invasive @entity5 died irrespective of the mode of treatment.(ABSTRACT TRUNCATED AT 400 WORDS)
