Non-invasive @entity298 in XXXX using PET and bioluminescence imaging.

@entity19 @entity5 @entity356 @entity298
BACKGROUND: Non-invasive imaging of @entity298 remains challenging. The aim of this study was to compare positron emission tomography (PET) and bioluminescence imaging (BLI) for the early detection of @entity298 in a @entity19 model. METHODS: Female @entity19 were inoculated intraperitoneally with 1*10(7) HSC45-M2-luc @entity356 cells. The cells were stably transfected with the gene coding for firefly luciferase. @entity5 development was monitored using PET and BLI and in two subgroups, on days 3 and 4 or on days 6 and 7 after @entity5 cell inoculation. @entity5 nodules found on post mortem examination served as the reference standard for evaluating the images. RESULTS: PET detected 58/82 lesions (sensitivity 71  %). This method detected all (100  %) nodules larger than 6  mm, 88  % of nodules in the range of >2-4  mm, and even 58  % of small nodules measuring only 1-2  mm. BLI identified a total of 40/82 lesions (sensitivity 49  %). The difference between PET and BLI was statistically significant at p   <   0.05 (PET/BLI chi-square 8.2). CONCLUSIONS: PET was more sensitive than BLI for the detection of early @entity298 in our @entity19 model. The sensitivity of BLI largely depended on the site of the lesions in relation to the imaging device.
