Histopathology of XXXX with paraproteinemia.

@entity1 @entity738 @entity1358 @entity16925 @entity33961 @entity3139 @entity165
Fifty-three cutaneous biopsies from 22 @entity1 with @entity33961 ( @entity33961 ) were reviewed. One or more biopsies from each @entity1 displayed a typical pattern of palisading histiocytic xanthogranuloma with bands of hyaline @entity16925 . Multiple foam cells and Touton giant cells were present, and atypical, bizarre-appearing foreign body giant cells were characteristic. @entity165 clefts were found in 18 specimens, and lymphoid nodules were found in 24, 8 of which had germinal center formation. Twenty-one specimens contained foci of plasma cells, and these were located perivascularly, at the periphery of lymphoid nodules, and, as infiltrates, between dermal collagen bundles. Unique features were @entity3139 , often appearing as @entity1358 , and a rare but distinctive palisading @entity165 cleft @entity738 . The cytoplasm of giant cells and histiocytes contained PAS-positive, diastase-resistant polysaccharide. Examination of 3 cases by electron microscopy revealed dendritic cells in the epidermis and vacuolated dermal histiocytes. S-100 antibody was negative in 3 cases. Leukocyte monoclonal antibody studies in 6 @entity1 showed predominantly T-helper lymphocytes within the @entity738 . @entity33961 is a T-helper cell, non-X histiocytic @entity738 with a distinctive histopathology.
