XXXX pathways are associated with improved long-term survival.

@entity5 @entity1 @entity14
INTRODUCTION: The impact of @entity5 @entity1 pathways (CPP) on long-term outcome after surgery for @entity14 has not been documented. This study aimed to investigate the effect of CPP on survival in @entity1 who underwent surgery for @entity14 . METHODS: This was a retrospective cohort study performed in a single centre on prospectively collected data from a national database, the Danish @entity14 Group. In total, we reviewed 309 consecutive @entity1 (145 females) with a median age of 70 years (range: 30-92 years), who underwent surgery for @entity14 between 2007 and 2009. RESULTS: A total of 148 @entity1 who underwent elective surgery after the introduction of CPP on 1 April 2008 had a decrease in the median number of days from referral to endoscopy (from 8 to 6, p = 0.001, from referral to oncological treatment (from 46.5 to 32 days, p < 0.001) and from referral to surgery (from 28 to 22 days, p = 0.066), but this latest reduction was not significant. Overall survival (OS) was analysed using the Kaplan Meier method; and variables were compared with the log rank test. The 60-month OS was significantly improved from 61.1% in those who were operated before 1 April 2008 (n = 161) to 72.6% in the CPP group operated after 1 April (p = 0.026). Using the Cox regression model, we found that CPP was an independent factor associated with survival (p = 0.032, hazard ratio = 0.661, 95% confidence interval: 0.454-0.964). CONCLUSION: Introduction of CCPs in a single centre was associated with a significant improvement of overall sur-vival, and using Cox regression we found that the CPP was an independent marker for survival. Larger studies are needed to clearly understand the effect of CPP. FUNDING: not relevant. TRIAL REGISTRATION: not relevant.
