[Locally administered XXXX vs. standard analgesia for laparoscopic cholecystectomy].

@entity1 @entity10964 @entity1340 @entity1342 @entity158
BACKGROUND: It is unknown which analgesic modality gives better results after a laparoscopic cholecystectomy. The aim of this study was to compare the analgesic efficacy of @entity1342 for local use against that of intravenous @entity10964 in laparoscopic cholecystectomy. METHODS: A non-inferiority randomized clinical trial. Fifty @entity1 with laparoscopic cholecystectomy were included into two separate groups. INTERVENTION: 0.75 % @entity1342 infiltrated at the trocar insertion sites and in the gallbladder fossa compared with intravenous @entity10964 . MEASUREMENTS: The primary outcome was @entity158 , which was assessed using the visual analog scale during the first 24 hours. Secondary outcomes were the presence of adverse effects, and the need for analgesic rescue with @entity1340 . RESULTS: The visual analog scale average for @entity158 at the conclusion of the surgery was 3.8 in the @entity1342 vs. 3.56 in the @entity10964 groups, while at 6, 12 and 24 hours the values were 2.64, 1.92 and 1.28, respectively, for @entity1342 versus 2.6, 1.88 and 1.2, respectively, for @entity10964 . No adverse effects were observed in either group, and the two groups exhibited similar needs for analgesic rescue with @entity1340 . CONCLUSIONS: Infiltration of 0.75 % @entity1342 at the trocar insertion sites and the gallbladder exhibits analgesia similar to IV @entity10964 during the first 24 hours post-laparoscopic cholecystectomy without adverse effects.
