Pathological diagnostic criteria for XXXX associated with cortical Lewy bodies: review and proposal for a descriptive approach.

@entity1 @entity527 @entity303 @entity73 @entity3072 @entity51 @entity1832 @entity195
In recent years @entity303 histologically characterised by the presence of cortical Lewy bodies has been increasingly recognised. There is now need for a scheme for an internationally acceptable scheme for pathological diagnosis and classification so that clinical, pathological and molecular features of disease can be correlated. Recent observations made by different groups in large @entity1 series have used slightly different pathological criteria resulting in at least seven different diagnostic terms. In some @entity1 the only cortical pathology is the presence of Lewy bodies, while in the majority of @entity1 there are coexisting pathological changes which either overlap with those seen in @entity195 ( @entity195 ). Cortical Lewy bodies can also be present in @entity1 who do not have any obvious @entity73 . A problem with equating studies from different groups is that different criteria have been used to define @entity195 , so that establishing the relevance of cortical Lewy bodies themselves to @entity73 and separating this from the contribution which may be related to the @entity195 pathology is problematic. The lesions which appear to be of most relevance to potential @entity73 in @entity1832 are cortical Lewy bodies, Lewy-related neurites, @entity527 , @entity3072 , neuronal and synaptic loss, @entity51 . It is possible to operationally classify @entity1 with @entity73 and cortical Lewy bodies into three main groups, @entity1832 , @entity1832 with plaques, and @entity1832 with plaques and tangles. There are frequent cases which overlap these groups making operational classification difficult in practice. A descriptive classification, in which the severity of different pathological changes is rated, is easy to use in practice. As new molecular risk factors for @entity195 or @entity1832 are revealed they will need to be related to morphological and clinical features. A descriptive diagnostic assessment for @entity1832 will facilitate such studies and makes no judgements as to what these relationships will be.
