Outcome of childhood XXXX in Jordan.

@entity1 @entity2008 @entity981
BACKGROUND: Accurate data about childhood @entity981 ( @entity981 ) in low- and middle-income countries are lacking. Our study is designed to assess survival of childhood @entity981 at King Hussein Cancer Center (KHCC) using modified St. Jude @entity1 's Research Hospital protocols. @entity1 AND METHODS: We reviewed the medical records of @entity1 1-18 years of age who were diagnosed with @entity981 and treated at KHCC from January 2003 through December 2009. Disease characteristics and outcome were analyzed. RESULTS: Over a 7-year period, 300 @entity1 with @entity981 were treated. One hundred and seventy-three (57.7%) were males and 127 (42.3%) were females. The median age at diagnosis was 5 years. One hundred and fifty-seven (52.3%) @entity1 were classified as low-risk, 118 (39.3%) were standard-risk and 25 (8.3%) were high-risk. Two hundred and sixty-two (88.5%) @entity1 had pre-B cell phenotype and 34 (11.5%) had T-cell phenotype. Two hundred and seventy-three (91.3%) @entity1 were classified as having CNS I disease, 24 (8%) had CNS II, and 2 (0.67%) had CNS III. @entity2008 included: t(12;21) in 30 (12%) @entity1 and t(9;22) in 18 (7.4%). Four (1.3%) @entity1 died in induction, 6 (2%) died in first remission and 27 (9%) relapsed. After a median follow-up of 34.5 months (range 0.32-84.5), the estimated 5-year event free survival and overall survival were 80% and 89%, respectively. CONCLUSION: Treatment protocols developed by major cooperative groups and institutions to treat childhood @entity981 was successfully adapted and suggest that such an approach may be useful in other low- and middle-income countries.
