Increased plasma levels of XXXX in mild @entity73 .

@entity1 @entity32 @entity198 @entity303 @entity73 @entity3072 @entity179 @entity195 @entity15901 @entity2414 @entity528
BACKGROUND: @entity195 ( @entity195 ) is a progressive @entity179 characterized by an irreversible @entity73 and @entity528 associated with @entity3072 . @entity73 ( @entity73 ) is a prodromal stage of @entity195 and is associated with @entity2414 and a high risk of developing @entity195 . @entity15901 ( @entity15901 ) is an acute phase protein. Our previous studies have shown that exposure to inflammatory stimuli resulted in elevated @entity15901 levels in brain microglia and astrocytes implicating @entity15901 in @entity198 . Therefore, we hypothesize that there may be a significant change in the plasma @entity15901 levels in @entity1 with @entity73 and @entity195 when compared to healthy control subjects. METHODS: Forty-one @entity1 with @entity73 , 62 @entity1 with @entity195 and 38 healthy elderly control subjects were recruited for this study. They were given a comprehensive battery of neuropsychological tests including a mini-mental status examination (MMSE) and clinical @entity303 rating (CDR). A variety of clinical information was collected from the semi-structured questionnaire administered. The @entity15901 levels were measured using a specific enzyme-linked immunosorbent assay in the plasma, which had been collected early in the morning after overnight fasting. RESULTS: The @entity15901 levels were significantly higher in @entity73 @entity1 compared to the healthy control subjects and @entity195 @entity1 [control vs. @entity73 (p=0.005); @entity73 vs. @entity195 (p=0.009)]. There was a significant negative correlation between the @entity15901 levels and CDR scores (r=-0.245, p=0.014), and there was a positive correlation between the @entity15901 levels and MMSE scores (r=0.317, p=0.001) among all of the @entity73 and @entity195 @entity1 . CONCLUSION: @entity73 represents a prodromal stage of @entity195 , and @entity32 occurs as one of the earliest pathological events in @entity195 . Thus, increased plasma @entity15901 levels during @entity73 could be helpful in predicting the progression from @entity73 to @entity195 .
