Relationship between @entity455 and age-associated changes in the XXXX kidney.

@entity1 @entity82 @entity455 @entity101 @entity3808 @entity453 @entity731 @entity631
To investigate the relationship between @entity731 and age-associated changes in the normal @entity1 kidney, autopsy findings and renal histology from 57 individuals with mild systemic @entity731 (group I), were compared to 57 sex- and age-matched individuals with moderate-to-severe @entity731 (group II). Age, sex, body build, the presence or absence of @entity101 , semiquantitative aorta and coronary-artery @entity731 scores, organ weights, and the percent of globally @entity3808 glomeruli were determined in each. Glomerular area, arcuate/interlobular arteries, and percent @entity82 were measured using standard morphometric techniques. Group I individuals had a 8.3 +/- 7.0% incidence of @entity3808 glomeruli, compared to 15.4 +/- 16.3% in group II (mean +/- SD, P less than 0.01). Relative intrarenal arterial wall area was increased in group II (60 +/- 12%) compared to group I (55 +/- 11%, P less than 0.05). The mean glomerular area of nonsclerotic glomeruli was greater in group II (23,700 +/- 6,000 sq mu) than in group I (19,600 +/- 3,700 sq mu, P less than 0.01), suggesting that there were compensatory increases in glomerular size in group II. Interstitial @entity82 was similar in both groups. The relative impact of age, sex, body build, @entity101 , systemic @entity731 , @entity455 and @entity82 on @entity631 and glomerular size was investigated using multiple linear regression. Both age and @entity455 exhibited highly significant, independent associations with @entity631 . Glomerular area was positively correlated with heart weight and @entity453 . In contrast, there was no independent correlation between glomerular area and @entity631 .(ABSTRACT TRUNCATED AT 250 WORDS)
