Bronchial lesions of @entity19 model of @entity565 are preceded by immune complex XXXX and induced bronchial associated lymphoid tissue (iBALT).

@entity2086 @entity1 @entity59 @entity1333 @entity19 @entity565 @entity1184 @entity39 @entity61 @entity11979 @entity358 @entity58 @entity1312
UNASSIGNED: We systematically examined by immune histology the lungs of some widely used @entity19 models of @entity565 . These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal or aerosol challenges 3 days apart. Within 24   h after a single challenge there is fibrinoid @entity39 of arterial walls with deposition of immunoglobulin (Ig) and OVA and infiltration of eosinophilic polymorphonuclear cells that lasts for about 3 days followed by peribronchial B-cell infiltration and slight reversible @entity1184 ( @entity1184 ). After two challenges, severe @entity1333 is present at 6   h, increases by 72   h, and then declines; B-cell proliferation and significant @entity1184 ( @entity1184 ) and bronchial smooth @entity2086 recur more prominently. After three challenges, there is significantly increased induced bronchus-associated lymphoid tissue (iBALT) formation, @entity1184 , and smooth @entity2086 . Elevated levels of @entity61 cytokines, @entity58 , @entity59 , and @entity1312 , are present in bronchial lavage fluids. Sensitized @entity19 have precipitating antibody and positive Arthus skin reactions but also develop significant levels of IgE antibody to OVA but only 1 week after challenge. We conclude that the @entity358 induced in these models is preceded by immune complex-mediated @entity1333 and iBALT formation. There are elevations of @entity61 cytokines that most likely produce bronchial lesions that resemble @entity1 @entity565 . However, it is unlikely that mast cell-activated atopic mechanisms are responsible as we found only a few presumed mast cells by @entity11979 and metachromatic staining limited to the most proximal part of the main stem bronchus, and none in the remaining main stem bronchus or in the lung periphery.Laboratory Investigation advance online publication, 1 June 2015; doi:10.1038/labinvest.2015.72.
