Association between b2-Adrenergic Receptor-16Arg/ XXXX Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

@entity72113 @entity1 @entity2162 @entity286 @entity3549 @entity4022 @entity534 @entity1030
BACKGROUND: The association between b2-adrenergic receptor ( @entity2162 ) -16Arg/ @entity4022 polymorphism ( @entity72113 ) and @entity1030 ( @entity1030 ) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship. METHODS: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, @entity3549 ) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association. RESULTS: Eleven studies, comprising 1,128 @entity1030 @entity1 and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the @entity2162 -16Arg/ @entity4022 polymorphism and @entity1030 risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the @entity2162 -16Arg/ @entity4022 polymorphism and @entity1030 risk among smoking Asians under the dominant genetic model and allele model ( @entity534 vs. @entity4022 ) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups. CONCLUSION: This meta-analysis suggested that the @entity2162 -16Arg/ @entity4022 polymorphism might be a potential risk factor for the development of @entity1030 in smoking Asian populations, but not in European descendents, and @entity286 smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.
