[2 epidemics of arsenical XXXX in the treatment of trypanosomiasis, Uganda, 1992-1993].

@entity1 @entity75 @entity1835 @entity26922 @entity13739 @entity7247 @entity25 @entity18884
Since 1988, the french non-governmental organisation M  decins Sans Fronti  res is running a control program of @entity1 @entity7247 in the district of Moyo, North-Uganda. Between 1988 and 1993, more than 7,000 @entity1 were diagnosed and treated. Since 1988, it has been noted that incidence of @entity26922 reaction had increased systematically between June and October of each year, indicating strong seasonal variation. In 1992 and 1993, two outbreaks of arsenical reactive @entity75 (ARE) occurred in the @entity25 center of Adjumani. The incidence of ARE suddenly exceeded 10% of the @entity1 treated by @entity26922 during August 1992 and September 1993. The onset of 80% of those "epidemic" cases, occurred between the 5th and the 11th day of treatment. Two retrospective studies were conducted in 1992 (75 cases) and in 1993 (51 cases). Among the risk factors studied, two appear to increase the risk of ARE: the prescription of @entity18884 to treat @entity13739 during the @entity26922 cure and the @entity1835 general clinical conditions of @entity1 . These observations suggest that exogenous co-factors could be involved in the occurrence of ARE. Recommendations were to avoid administration of diffusible anti-helminthic treatment during the cure, and to improve the general conditions of @entity1 before the cure of @entity26922 .
