@entity854 in XXXX : relationship to macrovascular endothelial function and markers of endothelial activation.

@entity32 @entity297 @entity625 @entity40109 @entity409 @entity1753 @entity102 @entity854 @entity35 @entity309 @entity1590
OBJECTIVE: To determine the time course of @entity854 and the link with macrovascular endothelial function and circulating markers of endothelial activation in @entity1753 ( @entity1753 ) in @entity35 . METHODS: Microvascular function/structure and mechanics were studied in third-order mesenteric arteries subjected to flow and/or pressure on day 4 (preclinical @entity625 ), day 11 ( @entity625 ), day 33 (severe disease), and day 90 (when @entity32 has resolved) after @entity1753 induction. Macrovascular function was studied in aortic rings, and blood pressure, plasma levels of @entity40109 ( @entity40109 ), @entity1590 ( @entity1590 ), and @entity297 ( @entity297 ) were measured at each time point. RESULTS: Mesenteric flow-mediated vasodilation was significantly reduced from @entity625 to @entity102 , whereas increased microvascular arterial stiffness was evident only on day 33. @entity409 was observed only on day 33. Thus, on day 90, whereas @entity35 with @entity1753 recovered normal macrovascular endothelial function, microvascular endothelial function remained impaired. No correlation was found between micro- and macrovascular endothelial function throughout the course of @entity625 (r = 0.180, P = 0.229). Furthermore, no correlation was found between @entity40109 levels, @entity1590 levels, and endothelial function whatever the vascular bed. @entity1753 was not associated with change in blood pressure or VCAM levels. CONCLUSION: Our findings indicate that microvascular @entity409 occurs earlier than macrovascular @entity409 and microvascular arterial stiffness during @entity625 , suggesting that microvascular endothelial function would be a valuable tool for the early assessment of cardiovascular risk in @entity309 . Neither the @entity1590 level nor the @entity40109 level is a good marker of micro- or macrovascular @entity409 .
