Weight gain since age 20 is associated with XXXX in normal weight individuals.

@entity1 @entity1561 @entity28
BACKGROUND AND AIMS: Interventions for lifestyle diseases including @entity1561 ( @entity1561 ) have focused on overweight and @entity28 populations. The impact of adult weight gain on @entity1561 development among normal weight individuals remains unclear. METHODS: In this cross-sectional study, we collected data from @entity1 presenting to a health check-up program. Ultrasound-diagnosed @entity1561 prevalence was examined over 1-kg increments of weight change since age 20. Relative risks (RR) were calculated in @entity1 and @entity1 stratified by current weight (normal, overweight, and @entity28 ). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusting for potential confounders. RESULTS: Among 21,496 @entity1 , 3,498 cases of @entity1561 (16.3%) were observed. Prevalence of @entity1561 increased with weight gain since age 20; among the 10.1-11.0 kg weight gain group, 41.6% of @entity1 and 24.8% of @entity1 had @entity1561 . Multivariate analysis by quartiles showed that weight change was significantly associated with @entity1561 risk in @entity1 and @entity1 . Risk of @entity1561 associated with weight change (10-kg increments) was significantly higher in normal weight individuals ( @entity1 : OR 7.53, 95% CI 4.99-11.36, @entity1 : OR 12.20, 95% CI 7.45-19.98) than overweight ( @entity1 : OR 1.61, 95% CI 0.91-2.85, @entity1 : OR 2.90, 95% CI 0.99-8.54) and @entity28 ( @entity1 : OR 4.0, 95% CI 2.97-5.39, @entity1 : OR 2.68, 95% CI; 2.00-3.60). CONCLUSIONS: @entity1561 is robustly associated with weight change since age 20. This effect appears particularly strong in individuals at normal weight, suggesting an important role for early and longitudinal weight monitoring, even among healthy individuals at normal weight.
