Altered Contralateral Auditory Cortical Morphology in Unilateral Sudden XXXX .

@entity1 @entity393 @entity1274
OBJECTIVE: To investigate the cerebral gray matter volume alterations in unilateral sudden @entity1274 @entity1 within the acute period by the voxel-based morphometry method, and to determine if @entity393 is associated with regional gray matter alterations in unilateral sudden @entity1274 @entity1 . STUDY DESIGN: Prospective case study. SETTING: Tertiary class A teaching hospital. @entity1 : Thirty-nine @entity1 with left-side unilateral sudden @entity1274 and 47 @entity1 with right-side unilateral sudden @entity1274 . INTERVENTION: Diagnostic. MAIN OUTCOME MEASURE: To compare the regional gray matter of unilateral sudden @entity1274 @entity1 and healthy control @entity1 . RESULTS: Compared with control groups, @entity1 with left side unilateral sudden @entity1274 had significant gray matter reductions in the right middle temporal gyrus and right superior temporal gyrus, whereas @entity1 with right side unilateral sudden @entity1274 showed gray matter decreases in the left superior temporal gyrus and left middle temporal gyrus. A significant negative correlation with the duration of the sudden @entity1274 (R=-0.427, p=0.012 for left-side unilateral SSNHL and R=-0.412, p=0.013 for right-side unilateral SSNHL) was also found in these brain areas. There was no region with increased gray matter found in both groups of unilateral sudden @entity1274 @entity1 . CONCLUSIONS: This study confirms that detectable decreased contralateral auditory cortical morphological changes have occurred in unilateral SSNHL @entity1 within the acute period by voxel-based morphometry methods. The gray matter volumes of these brain areas also perform a negative correlation with the duration of the disease, which suggests a gradual brain structural impairment after the progression of the disease.
