Detection of Plaque Neovascularization by Optical Coherence Tomography: Ex Vivo Feasibility Study and In Vivo Observation in XXXX With @entity951 .

@entity1 @entity2295 @entity951 @entity165
OBJECTIVES: The purposes of this study were: (1) to assess the feasibility of optical coherence tomography (OCT) for detecting @entity2295 ; and (2) to clarify the impact of @entity2295 on coronary vessel behavior over time. BACKGROUND: Plaque @entity2295 may be related to plaque vulnerability. METHODS: In an ex vivo study, a total of 55 coronary plaques from 31 @entity1 cadavers were examined by OCT. Plaque @entity2295 was diagnosed based on the presence or absence of microchannels (MCs) by OCT. In an in vivo study, we explored 83 major coronary arteries from 42 @entity1 with @entity951 . A total of 56 coronary plaques were selected from non-culprit (non-stented) lesions with plaque burden >40% by intravascular ultrasound (IVUS). These plaques were classified into two groups based on the presence or absence of MC by OCT. RESULTS: In the ex vivo study, the sensitivity and specificity of OCT to detect @entity2295 were 52% and 68%, respectively. In the in vivo study, MC was detected in 25 plaques (44.6%). High-density lipoprotein @entity165 was significantly lower in the MC group vs the non-MC group (42.7    7.8 mg/dL vs 51.6    14.4 mg/dL; P=.02). Percent change in lumen volume index (VI) in the MC group was significantly greater vs the non-MC group (P=.01). Percent change in lumen VI correlated significantly with percent change in external elastic membrane VI (P=.01). CONCLUSIONS: OCT was feasible for detecting @entity2295 of coronary plaques. Serial OCT examinations revealed that coronary plaques with @entity2295 showed greater luminal narrowing as a result of inadequate adaptive vessel remodeling.
