@entity2508 activation, via downregulation of @entity53044 , mediates sex differences in @entity8147 -salt XXXX vascular reactivity.

@entity455 @entity101 @entity2508 @entity4286 @entity13358 @entity2647 @entity8147 @entity53044 @entity35
@entity2508 has been reported to play a @entity455 associated with mineralocorticoid @entity101 . We hypothesized that, compared with female @entity35 , an upregulation of @entity2508 signaling in the vasculature of male @entity35 contributes to augmented contractile responses in mineralocorticoid @entity101 . Uninephrectomized male and female @entity35 received @entity8147 ( @entity8147 ) pellets (200 mg per animal) and saline to drink for 3 weeks. Control uninephrectomized @entity35 received tap water to drink. Blood pressure, measured by telemetry, was significantly higher in male @entity8147 @entity35 (191+/-3 mm Hg) compared with female @entity8147 @entity35 (172+/-7 mm Hg; n=5). @entity8147 treatment resulted in augmented contractile responses to @entity2647 in aorta (22+/-3 mN; n=6) and small mesenteric arteries (13+/-2 mN; n=6) from male @entity8147 @entity35 versus uninephrectomized male @entity35 (16+/-3 and 10+/-2 mN, respectively; P<0.05) and female @entity8147 @entity35 (15+/-1 and 11+/-1 mN, respectively). @entity2508 inhibition with @entity4286 (10 micromol/L) abrogated increased contraction to @entity2647 in aorta (14+/-2 mN) and small mesenteric arteries (10+/-2 mN) from male @entity8147 @entity35 , without any effects in arteries from male uninephrectomized or female animals. Compared with the other groups, phosphorylated @entity2508 levels were increased in the aorta from male @entity8147 @entity35 , whereas @entity53044 expression was decreased. @entity13358 plasma levels, which positively regulate @entity53044 activity, were reduced in male @entity8147 -salt @entity35 . We speculate that augmented vascular reactivity in male @entity101 @entity35 is mediated via activation of the @entity2508 pathway. In addition, @entity53044 and @entity13358 play regulatory roles in this process.
