[Circadian rhythm and variability of blood pressure and target organ damage in essential XXXX ].

@entity1 @entity101 @entity15032 @entity4346 @entity551
The aim of this study was to evaluate the influence of blood pressure variability and circadian rhythm on left ventricular mass and urinary albumin excretion rate (UAE) in @entity1 with essential @entity101 . 82 untreated @entity1 (35 @entity1 and 47 @entity1 ; mean age 41.1 +/- 13.7) were recruited to this study. Mean office blood pressure at entry was 152/97 mmHg. Ambulatory blood pressure monitoring (ABPM) was performed using an Medilog @entity15032 recorder (Oxford). Blood pressure variability was estimated as the standard deviation (SD) of systolic and diastolic ambulatory blood pressure. Urinary albumin excretion (UAE) was estimated by the radioimmunoassay during two separate days. Echocardiography was used to measure left ventricular mass and left ventricular mass index (LVMI). The median urinary albumin excretion for the whole group was 8.2 mg/day; in 18 @entity1 (21.9%) microalbuminuria was present. Left ventricular mass index in a whole group was 109.1 g/m2; in 23 subjects (28.0%) @entity4346 ( @entity4346 ) was found. @entity1 with microalbuminuria as well as with @entity4346 had higher office and 24 hour ambulatory systolic and diastolic blood pressure and higher systolic blood pressure variability. During ABPM 18 @entity1 with @entity551 (non-dippers) were found; they did not display more frequent prevalence of target organ damage. Increased 24-hour blood pressure variability present in @entity101 subjects with both microalbuminuria and @entity4346 may suggest that this phenomenon plays role in development of target organ damage.
