Effects of coexisting XXXX and @entity6 on arterial stiffness.

@entity1 @entity2002 @entity101 @entity6 @entity13519 @entity2333 @entity13520 @entity413 @entity122 @entity414
@entity101 ( @entity101 ) is frequently associated with @entity6 ( @entity6 ) and its prevalence doubles in diabetics compared to the general population. This high prevalence is associated with increased stiffness of large arteries, which often precedes macrovascular events. The aim of our study was to evaluate the influence of @entity6 on @entity2333 in @entity1 with one disease or the other compared to those with both @entity6 . We studied 220 @entity1 , 50 with type II @entity6 (Group A), 50 with @entity101 (Group B), 85 with both diseases (Group C), and 35 healthy subjects (HS). Regional arterial stiffness was assessed by automatic measurement of the carotid-femoral pulse wave velocity ( @entity122 ). For each @entity1 , we evaluated: age, sex, body mass index, smoking habit, heart rate, @entity13519 / @entity13520 , pulse pressure (PP), mean BP, fasting @entity413 , lipid profile, @entity414 , and @entity2002 . Group C had significantly more @entity1 and non smokers and the highest PP (61+/-14 mmHg). Of biochemical parameters, only @entity2002 was higher in Group A and in Group C (P<0.01 and P<0.001, respectively). Group C had a significantly higher @entity122 than the other four groups (P<0.0001). Stepwise forward regression analysis showed that fasting @entity413 was the first independent determinant of @entity122 (P<0.0001). In conclusion, this study shows that @entity1 with @entity6 and @entity101 have higher arterial stiffness compared to HS and those with one disease or the other. Fasting @entity413 is the major independent determinant of @entity122 , which may be used as a relevant tool to assess the influence of cardiovascular risk factors on arterial stiffness in high-risk @entity1 .
