Aggressive Intrasegmental Recurrence of XXXX after Radiofrequency Ablation: Risk Factors and Clinical Significance.

@entity1 @entity96 @entity5 @entity146 @entity157
UNASSIGNED: Purpose To evaluate the frequency, risk factors, and clinical significance of @entity146 ( @entity146 ) found after radiofrequency (RF) ablation for @entity157 ( @entity157 ). Materials and Methods Institutional review board approval was obtained for this retrospective study. Between March 2005 and December 2010, 539 @entity1 (414 @entity1 , 125 @entity1 ; mean age, 57.91 years; age range, 30-82 years) underwent ultrasonography-guided percutaneous RF ablation as a first-line treatment for a single @entity157 classified as @entity96 ( @entity96 ) stage 0 or A. @entity146 of @entity157 was defined as (a) initial @entity5 recurrence with disease-free status at least 6 months after initial RF ablation and (b) the simultaneous development of multiple nodular (at least three) or infiltrative @entity5 recurrence in the treated segment. @entity1 were stratified into two groups: those with @entity146 (n = 20) and those without @entity146 (n = 519) during follow-up. Risk factors for @entity146 were assessed with logistic regression analysis, and risk factors for long-term overall survival were assessed with time-dependent Cox proportional hazard models. Results In a median follow-up period of 49 months (range, 6-95 months), @entity146 was observed in 3.7% of the @entity1 (20 of 539 @entity1 ), with the frequency increasing to 15% in the subgroup with periportal @entity157 (11 of 72 @entity1 ). AIRs manifested as either multiple nodular type (n = 14, @entity96 stage A or B) or diffusely infiltrative type with @entity5 thrombus formation (n = 6, @entity96 stage C). At multivariate analysis, @entity5 location and younger @entity1 age were significant risk factors for @entity146 . The presence of @entity146 during the follow-up period has a significant effect on the overall survival rate (hazard ratio = 5.72, P = .002). Conclusion The overall frequency of @entity146 after RF ablation for @entity157 was low, with periportal location and @entity1 age showing a significant relationship to the development of @entity146 . The occurrence of @entity146 had an adverse effect on overall survival rate. (  ) RSNA, 2015.
