XXXX or @entity681 for coronary surgery: comparison of postoperative respiratory impairment.

@entity1 @entity308 @entity681 @entity891 @entity1875 @entity544 @entity158 @entity1937
BACKGROUND AND OBJECTIVE: High-dose opioid anaesthesia contributes to decreasing metabolic and hormonal stress responses in @entity1 undergoing cardiac surgery. However, the increase in context-sensitive half-life of opioids given as a high-dose regimen can affect postoperative respiratory recovery. In contrast, @entity1937 can be given in high doses without prolonging context-sensitive half-life due to its rapid metabolism. Therefore, we performed a prospective, randomized trial to compare anaesthesia consisting of @entity1875 / @entity1937 or @entity1875 / @entity681 with regard to postoperative respiratory function and outcome. METHODS: @entity1 undergoing coronary artery bypass grafting were randomized to a @entity1875 / @entity1937 (0.5-1.0 microg kg(-1) min(-1)) or @entity1875 / @entity681 (30-40 ng kg(-1) min(-1)) based anaesthetic. @entity544 response, forced expiratory volume in one second, vital capacity, and functional residual capacity were measured 1 day prior to the operation, 1 h before extubation, 1, 24 and 72 h after extubation. In addition, the incidence of @entity891 , intensive care unit and postoperative length of stay were compared. @entity1 and physicians were blinded to the treatment group. RESULTS: Twenty-five @entity1 in each treatment group completed the study. There was no difference between @entity1 of the treatment groups regarding demographics, risk- or @entity158 scores. In all @entity1 , @entity544 response, forced expiratory volume in one second, vital capacity and functional residual capacity were decreased postoperatively compared to baseline. @entity1 randomized to @entity1937 had less @entity308 of @entity544 response, less @entity891 and shorter postoperative length of stay (12 d vs. 10 d) than after @entity681 (P < 0.05). CONCLUSIONS: Intraoperative use of high-dose @entity1937 for coronary artery bypass grafting may be associated with improved recovery of pulmonary function and shorter postoperative hospital length of stay than @entity681 .
