Maternal reproductive history and the risk of isolated XXXX .

@entity1 @entity8 @entity600 @entity2419 @entity3384 @entity4297
We examined the relationship between maternal reproductive history and the newborn's risk of isolated @entity600 in a large case-control cohort from the Polish Registry of @entity600 . @entity600 were classified into four categories: isolated @entity4297 (n=1673), isolated @entity2419 (n=255), @entity3384 with or without @entity2419 (n=448) and @entity8 (n=103). The case groups were compared with a shared group of 2068 controls recruited in the same time period and geographic area. Multivariable logistic regression was used to assess the risk associated with maternal gravidity and of previous miscarriages after accounting for maternal age and other potential risk factors. In unadjusted analyses, maternal gravidity was significantly associated with increased risk of all four classes of @entity600 . After adjustment, a significant association persisted for @entity4297 [odds ratio (OR)=1.22, [95% confidence interval (CI) 1.09, 1.36], P=0.0007] and @entity3384 with or without @entity2419 (OR=1.21, [95% CI 1.09, 1.36], P=0.0005). A similar trend existed for isolated @entity2419 (OR=1.18, [95% CI 1.02, 1.37], P=0.03). There was no appreciable increase in the risk of @entity600 associated with a maternal history of miscarriages, but a trend for a protective effect on the occurrence of @entity3384 with or without @entity2419 was observed (OR=0.72, [95% CI 0.52, 0.99], P=0.045). Based on our data, maternal gravidity represents a significant risk factor for @entity4297 and @entity3384 with or without @entity2419 in the newborn @entity1 . Our data do not support an increase in risk because of past history of miscarriages.
