Role of XXXX in Brain Metastasis of @entity0 : a Systematic Review and Meta-Analysis.

@entity1 @entity0 @entity5 @entity3 @entity1722
BACKGROUND: @entity0 is one of the most common @entity5 among @entity1 worldwide and the @entity1722 receptor plays an important role in its development and progression. This systematic review aimed to summarize the role of @entity1722 in brain @entity3 in @entity1 with @entity0 . MATERIALS AND METHODS: We conducted a literature search by advanced search in title field using the Scopus, Pubmed, and Google scholar databases until the end of June 2014. With @entity3 , metastatic, @entity1722 , brain, and @entity0 , as terms of search we selected 31 articles, which were reviewed by two independent and blinded expert reviewers. The studies were first selected according to their titles and abstracts. Quality of the studies were then assessed using the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) protocol for observational studies and CONSORT(Consolidation of Standards for Reporting Trials) protocol for clinical trials. For statistical analyses, we used STATA, version 11.0 software. Forest and funnel diagrams were drawn and for heterogeneity, index was also considered. Also we used meta regression analysis. RESULTS: Finally, we reviewed 10 studies. The prevalence of brain @entity3 in @entity1722 - positive @entity0 @entity1 was 24.9%. There was publication bias in the reviewed studies. Meta regression analysis showed that follow up time had no significant effect (p=0.396) on the prevalence of brain @entity3 . CONCLUSIONS: The results showed a high prevalence of brain @entity3 in @entity1722 positive @entity0 @entity1 .
