Astragalus polysaccharide suppresses excessive collagen accumulation in a XXXX model of @entity1732 -induced @entity2631 .

@entity16290 @entity641 @entity19 @entity2631 @entity14570 @entity720 @entity3078 @entity1732 @entity74 @entity792 @entity785
@entity785 is an @entity792 characterized by fibrotic changes in skin and other organs involving excessive collagen deposition. The @entity641 ( @entity641 ) signaling pathway plays a key role in the fibrotic process in @entity785 ( @entity785 ). @entity16290 ( @entity16290 ) isolated from one of the Chinese herbs, Astragalus mongholicus, are known to have a variety of immunomodulatory activities. The present study aimed to investigate the effect of @entity16290 on @entity641 signaling and its potential mechanism using a @entity19 model of @entity1732 -induced @entity2631 . @entity2631 was induced in C3H/He @entity19 by subcutaneous @entity1732 injections daily for 21 days. Skin samples were obtained 7, 14, and 21 days and @entity641 , @entity14570 , @entity3078 mRNA expression was observed by real time PCR. The @entity720 content which consistent with the collagen content in skin samples from the BLM-injected group was significantly higher than the PBS group, and corresponded with dermal thickening at the injection site. In contrast, @entity19 treated with @entity16290 after initiating BLM injection showed obviously lesser collagen content. Increased @entity641 , @entity14570 , @entity3078 mRNA expression were also observed in the BLM group. @entity641 , @entity14570 , @entity3078 expression was significantly lesser for the @entity16290 group than for the BLM group. In contrast, @entity641 mRNA expression was remarkably inhibited by @entity16290 . These results suggest that @entity16290 treatment may inhibit @entity641 production, and thus could be a potential drug for managing @entity74 such as @entity785 .
