The Expression of Notch/Notch Ligand, IL-35, XXXX , and Th17/Treg in Preeclampsia.

@entity1 @entity11191 @entity13060 @entity4155 @entity1468 @entity403 @entity10669 @entity22491 @entity72976
The aim of this study was to examine the interaction of Notch/Notch ligand with Th17/Treg, cytokines IL-35 and @entity4155 in cases of @entity1468 ( @entity1468 ). Methods. Peripheral blood was obtained from 42 @entity1468 @entity1 and 22 health pregnant @entity1 . The mRNA expressions of Notch/Notch ligand, Treg transcription factor @entity403 and Th17 transcription factor RORyt, @entity11191 and @entity10669 (IL-35 two subunits), and @entity4155 were determined by qPCR. The serum levels of @entity4155 and IL-35 were measured by ELISA. Results. It was observed that the expressions of @entity403 , @entity11191 , and @entity10669 in @entity1468 @entity1 were lower compared with normal pregnancy, whereas the RORyt expression was significantly increased. The results also demonstrated that @entity1468 @entity1 exhibited decreased levels of Treg-related cytokine IL-35, whereas @entity4155 was significantly increased. @entity1468 @entity1 expressed higher levels of Notch receptor (1-4) and Notch ligand of @entity22491 , whereas Notch ligand of @entity72976 was much lower. Furthermore, the levels of @entity403 T cells correlated positively with @entity13060 . In addition, there were positive correlations between the mRNA level of @entity4155 and @entity22491 . Conclusion. Our results indicated that maternal immunological changes may reverse maternal tolerance in @entity1468 , and this phenomenon may due to the Th17/Treg imbalance affected by Notch/Notch ligand.
