Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out XXXX in vivo.

@entity2194 @entity19 @entity10522 @entity20764 @entity4778 @entity164
The physiological roles of neuronal gap junctions in the intact brain are not known. The recent generation of the connexin-36 knock-out ( @entity20764 KO) @entity19 has offered a unique opportunity to examine this problem. Recent in vitro recordings in @entity20764 KO @entity19 suggested that @entity20764 gap junction contributes to various oscillatory patterns in the theta (approximately 5-10 Hz) and gamma (approximately 30-80 Hz) frequency ranges and affects certain aspects of high-frequency (>100 Hz) patterns. However, the relevance of these pharmacologically induced patterns to the intact brain is not known. We recorded field potentials and unit activity in the @entity4778 stratum pyramidale of the hippocampus in the behaving @entity164 ( @entity164 ) and @entity20764 KO @entity19 . @entity2194 (140-200 Hz) were present in both @entity164 and KO @entity19 and did not differ significantly in power, intraepisode frequency, or probability of occurrence. Thus, fast-field oscillations either may not require electrical synapses or may be mediated by a hitherto unknown class of gap junctions. Theta oscillations, recorded during either wheel running or rapid eye @entity10522 , were not different either. However, the power in the gamma frequency band and the magnitude of theta-phase modulation of gamma power were significantly decreased in KO @entity19 compared with @entity164 controls during wheel running. This suggests that @entity20764 interneuronal gap junctions selectively contribute to gamma oscillations.
