Structural manifestations of XXXX in the @entity35 and its reversal by insulin treatment.

@entity6 @entity10835 @entity13088 @entity2915 @entity35 @entity393 @entity2383
The structural effects of @entity6 and subsequent insulin treatment upon the contractile and supporting elements of the @entity35 myocardium were examined at progressive stages of both untreated and treated disease. @entity6 was induced by intravenous injection of @entity10835 , and tissue was examined after 6, 12, and 26 weeks. Insulin treatment began after 12 weeks of @entity6 and tissue from these animals was examined after the same intervals. Within the cardiocytes, @entity6 produced a focal yet progressive @entity393 , transverse tubules, and sarcoplasmic reticulum, and separation of the fasciae adherens was evident at the intercalated disk. @entity2383 was not evident. These cytoplasmic alterations were accompanied by intercellular and perivascular deposition of connective tissue, thickening of the endothelial cytoplasm with pinocytotic @entity2915 , and characteristic basal laminar changes. When insulin treatment began after 12 weeks of @entity6 , most, but not all, of these changes were reversed, and this reversal was essentially complete within 6-12 weeks. Even with longer periods of insulin treatment, cardiocytes still exhibited scattered areas of myofibril loss and extracellular matrix was retained. In contrast, @entity6 changes in the intercalated disk and capillaries, including their basal laminae, were completely and rapidly reversed. It is hypothesized that the structural manifestations of @entity13088 consist of two major components; the first is a short-term, physiologic adaptation to metabolic alterations, while the other represents degenerative changes for which the myocardium has only a limited capacity for repair.
