Treatment with some anti-inflammatory drugs reduces germ tube formation in XXXX strains.

@entity1 @entity3522 @entity117 @entity262 @entity2918 @entity5132 @entity375
@entity5132 is an opportunistic dimorphic fungus that inhabits various host mucosal sites. It can cause both superficial and serious @entity262 . Conversion from the @entity375 to the hyphal form has been associated with increased virulence and mucosal invasiveness. The aim of this study was to investigate the effect of @entity3522 and @entity117 on germs tube formation of different @entity5132 strains. @entity2918 may play an important role in fungal colonization. Nonsteroidal anti-inflammatory drugs are inhibitors of the cyclooxygenase isoenzymes. These drugs specifically block the biosynthesis of @entity1 prostaglandins by inhibiting one or both of cyclooxygenase isoenzymes. In tests for germ tube formation @entity3522 reduced the filamentation to the 12.5%- 5.1%. In the presence of @entity117 the filamentation was reduced up to 85-45% depending on the tested strain. Our results suggest that cyclooxygenase-depending synthesis of fungal @entity2918 is important for morphogenesis and fungal virulence. Inhibitors of cyclooxygenase isoensymes ( @entity117 and @entity3522 ) are effective in decreasing germ tube formation of @entity5132 .
