XXXX with concomitant watery @entity294 : an unusual association.

@entity1 @entity1289 @entity1369 @entity2178 @entity294 @entity1372 @entity177 @entity520 @entity3485 @entity972 @entity916 @entity4144
Four @entity1 presented to the emergency room with life-threatening @entity4144 and concomitant watery @entity294 . @entity3485 , @entity520 , and @entity177 were present in all 4 cases. In 2 @entity1 , @entity4144 followed initiation of @entity1289 ( @entity1289 ) inhibitor therapy, whereas 1 @entity1 experienced @entity4144 after a dose increase of an @entity1289 inhibitor, and the fourth @entity1 was on continuous @entity1289 -inhibitor therapy at the time of the @entity4144 episode. Two of the 3 @entity1 with functioning kidneys required hemodialysis to correct the @entity4144 , whereas the other @entity1 was on long-term hemodialysis therapy. In the 2 @entity1 in whom transtubular @entity972 (K+) gradients were available, their values ranged far below normal, indicating tubular failure to secrete K+. This abnormality was attributed to decreased distal delivery of @entity1372 and water and to @entity916 / @entity2178 / @entity1369 blockade. It has been proposed that @entity1369 blockade impairs the capacity of the colonic epithelial cells to secrete K+. In all 4 @entity1 the watery @entity294 ceased in parallel with the correction of serum K+ to normal values. It is suggested that @entity4144 , most likely by stimulating intestinal motility, induced the watery @entity294 in all 4 @entity1 . The watery @entity294 , however, failed to compensate for the renal tubular failure to secrete K+.
