Antibody to @entity6171 inhibits virus-induced airway hyperresponsiveness to XXXX in @entity840 .

@entity1 @entity32 @entity6171 @entity565 @entity840 @entity15609 @entity1800 @entity1729 @entity112
In @entity1 , respiratory viral infections lead to increased airway responsiveness and exacerbations of @entity565 . In the present study, the role of @entity6171 ( @entity6171 ) in virus-induced airway hyperresponsiveness and @entity32 was examined in @entity840 . In animals treated with control antibody, @entity15609 -3 virus significantly potentiated (219%) the @entity112 -induced increase in lung resistance compared with vehicle treatment. In addition, @entity1800 significantly increased (130 to 450%) the responsiveness of isolated tracheal segments to @entity112 in animals treated with control antibody. In @entity840 treated with control antibody, the numbers of eosinophils (226%), neutrophils (1,380%), and monocytes (626%) in bronchoalveolar lavage fluid were significantly increased after @entity1800 . The level of major basic protein in bronchoalveolar lavage fluid was not altered after @entity1800 . In addition, electron microscopic examination of eosinophils in airway tissue and alveolar lumen did not point to @entity1800 . In @entity840 treated with antibody to @entity6171 the virus-induced airway hyperresponsiveness to @entity112 both in vivo and in vitro was almost completely inhibited. In @entity840 treated with anti- @entity6171 , @entity1800 significantly increased the numbers of eosinophils (234%), neutrophils (1,255%), and monocytes (617%) in bronchoalveolar lavage fluid. These data suggest that @entity6171 plays an important role in airway hyperresponsiveness to @entity112 but not in the infiltration of eosinophils after @entity1729 .
