@entity33908 physical XXXX in @entity235 .

@entity3175 @entity235 @entity33908 @entity6720 @entity400 @entity11541 @entity2934 @entity734
@entity235 , surgically implanted with a chronic @entity11541 , were chronically dosed with @entity33908 (32 mg/kg/day) in four divided doses to attain @entity33908 plasma levels comparable to those observed in @entity235 dependent on @entity3175 (60 mg/kg/day). The time course of @entity33908 abstinence was studied, beginning not less than 2 weeks after stabilization levels had been achieved. The abstinence syndrome observed after abrupt discontinuation of @entity33908 was similar to the @entity3175 abstinence syndrome but differed in several important aspects. In @entity3175 -dependent @entity235 , there was a short burst of @entity400 very early in withdrawal (approximately 1-2 hr after the last dose of @entity3175 ) that was not seen in @entity33908 -dependent @entity235 . Signs of abstinence such as @entity400 , hot foot walking and twitches and jerks were more frequently observed in @entity33908 -dependent @entity235 than in @entity3175 -dependent @entity235 as were decreases in food and water intake and in body weight. The overall intensity of abstinence, as measured by the @entity3175 Withdrawal Abstinence Scale, was greater in @entity33908 -dependent @entity235 than in @entity235 dependent on either @entity2934 or @entity3175 . Plasma levels of @entity33908 and @entity6720 were nearly equal in @entity235 dependent on @entity3175 or on @entity33908 and were 4 to 10 times greater than the plasma levels of @entity3175 or @entity2934 in @entity3175 - or @entity2934 -dependent @entity235 , respectively. Furthermore, the plasma levels of @entity33908 and @entity6720 declined much more slowly than the levels of @entity3175 and @entity2934 . These results suggest that physical @entity734 on @entity3175 is caused by the accumulation and actions of @entity33908 .(ABSTRACT TRUNCATED AT 250 WORDS)
