The Ki67 index a prognostic marker in XXXX .

@entity1 @entity259 @entity5 @entity3
Our objective was to examine the usefulness of the Ki67 proliferation index as a prognostic marker in @entity1 with @entity259 ( @entity259 ). It is difficult to predict the prognosis of @entity259 by using conventional prognostic factors. Immunocytochemical analysis of @entity5 proliferation has been used as a prognostic tool in some @entity5 , but only rarely in @entity259 . In all, 71 @entity5 from 36 @entity1 were investigated, by using a semiautomatic image analysis programme. On average 10,000 nuclear profiles were counted per @entity5 , and the percentage of @entity5 cells expressing the proliferation marker, Ki67, was calculated. Primary @entity5 that had metastasised had higher Ki67 indices than primary @entity5 that had not metastasised. Recurrent lymph node @entity3 had higher Ki67 indices than the primary @entity5 . By using a Poisson model, it was possible to estimate the median survival time for individual @entity1 if the Ki67 index for the primary @entity5 and the age at surgery were known. The higher the Ki67 index and the age at operation were, the shorter was the survival. Estimating the median survival of individual @entity1 will be of help for planning the @entity1 ' life and postoperative follow-up and treatment.
