Hepatic XXXX partitioning.

@entity1 @entity844 @entity1674 @entity2690 @entity1561 @entity1718
PURPOSE OF REVIEW: A net retention of @entity1674 within the liver is a prerequisite for the development of @entity1561 . The accumulation of liver fat reflects an imbalance between @entity844 input and disposal. Here we summarize recent research into understanding the fate of @entity1718 within the hepatocyte. RECENT FINDINGS: Several recent studies have elucidated the contribution of different sources of @entity1718 to liver fat and to plasma @entity1674 . Some recent studies have suggested that, contrary to expectations, hepatic @entity844 oxidation is upregulated in @entity2690 -resistant individuals. A recent observation shows the potential importance of @entity844 transformation, especially desaturation, to determination of metabolic fate. These studies highlight our lack of understanding of the regulation of metabolic partitioning of @entity1718 within the @entity1 liver. SUMMARY: The regulation of hepatic @entity844 partitioning involves many factors; not least @entity2690 . @entity2690 undoubtedly regulates the supply of @entity1718 to the liver from adipose tissue; however, whether @entity2690 has a direct intrahepatic effect on hepatic @entity844 partitioning, in @entity1 , remains unclear. The transformation of @entity1718 , by desaturases, may have an important role in aiding the disposal of @entity1718 via oxidative pathways. Factors that upregulate hepatic @entity844 oxidation need to be elucidated.
