Relationship between soft tissue body composition and bone mass in perimenopausal XXXX .

@entity1 @entity604 @entity170 @entity79 @entity2331
OBJECTIVES: Perimenopause, the transition into menopause, marks the beginning of accelerated @entity604 , contributing to the development of @entity170 , a major public health problem. This perimenopausal transition has also been associated with a decrease in body lean mass, an increase in fat mass, and an increase in body weight. How these changes in fat mass and lean mass may influence @entity79 ( @entity79 ) is currently unknown. The purpose of this study is to determine the independent effect and relative contribution of lean mass and fat mass to @entity79 in perimenopausal @entity1 . MATERIAL AND METHODS: The sample consisted of 43 sedentary perimenopausal @entity1 (age: mean = 49.6; S.D. = 3.2) with an intact uterus and ovaries, participating in a study of exercise and perimenopausal symptoms. Total body @entity79 , regional @entity79 , and soft tissue body composition were measured by dual-energy X-ray absorptiometry. Other measures including age, height, weight, and serum FSH and E2 were also obtained. RESULTS: Findings revealed that 14% of these perimenopausal @entity1 had low bone mass ( @entity2331 ) in the lumbar spine and/or the femoral neck. Overall body fat mass and lean mass had positive relationships with @entity79 of lumber spine and the femur. However, using multiple regression analyses, only lean mass and ethnicity remained significant predictors for @entity79 of the femoral neck (r2 = 45%) with lean mass explaining more variance than ethnicity. Lean mass was the sole predictor of total proximal femur @entity79 explaining 38% of the variance. Fat mass was not a significant predictor of @entity79 at any skeleton site. CONCLUSIONS: These findings suggest that body lean mass, not fat mass, is a significant contributor to femoral @entity79 in perimenopausal @entity1 .
