Prediction of Early Reperfusion From Repeated Arterial XXXX Labeling Perfusion Magnetic Resonance Imaging During Intravenous Thrombolysis.

@entity1 @entity7959 @entity64 @entity432
BACKGROUND AND PURPOSE: There are few in vivo data on the pathophysiology of reperfusion during systemic thrombolysis. We monitored the time course of cerebral perfusion changes in @entity1 during thrombolysis with repeated arterial @entity7959 labeling perfusion magnetic resonance imaging. METHODS: Ten @entity1 with proximal @entity432 within 4.5 hours after symptom onset were prospectively enrolled. All @entity1 received intravenous thrombolysis during the magnetic resonance imaging examination. Repeated arterial @entity7959 labeling perfusion images were acquired during the 60-minute therapy and at follow-up after 24 to 72 hours. Clinical data, magnetic resonance imaging features, and cerebral perfusion changes were analyzed. RESULTS: Before thrombolysis, arterial @entity7959 labeling hypoperfusion and fluid-attenuation inversion recovery vascular hyperintensity in the territory of the occluded arteries were observed in all @entity1 . In 5 @entity1 , extensive arterial transit artifacts (ATA) developed in the hypoperfused area. The ATA corresponded with fluid-attenuation inversion recovery vascular hyperintensities. All 5 @entity1 who developed extensive ATA in the hypoperfused area had complete reperfusion after thrombolysis, whereas the 5 without extensive ATA showed no or only partial reperfusion (P<0.01). The development of ATA preceded the normalization of tissue perfusion. CONCLUSIONS: The development of ATA during thrombolysis is associated with early reperfusion after thrombolysis. arterial @entity7959 labeling assessment during intravenous thrombolysis has the potential to guide subsequent therapeutic strategies in @entity1 with @entity64 .
