Application of platelet/lymphocyte and neutrophil/lymphocyte ratios in early diagnosis and prognostic prediction in @entity1 with resectable XXXX .

@entity1 @entity32 @entity5 @entity1600 @entity204 @entity356
BACKGROUND: @entity356 is the fourth most frequent @entity5 and the second cause of @entity5 -related @entity204 worldwide. China has a high incidence of @entity356 . @entity32 is a critical component of @entity5 progression. It has been widely accepted that @entity356 is an inflammation-driven @entity5 . In this study, we investigated the application value of systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), in early diagnosis and prognostic prediction in @entity1 with resectable @entity356 . MATERIALS AND METHODS: One hundred and sixty-two @entity1 with resectable @entity356 were included and separated into groups according to median pre-operative PLR or NLR values (PLR low: < 208 or PLR high: >=  208, and NLR low: < 4.02 or NLR high: >=  4.02, respectively). To evaluate the changes in PLR or NLR values after operation, we introduced the concept of post-/pre-operative PLR or NLR ratios (< 1 indicated PLR or NLR values were decreased after operation, while >=  1 suggested not decreased PLR or NLR values). RESULTS: Pre-operative PLR and NLR levels were significantly higher in @entity356 @entity1 compared with the healthy subjects. Low pre-operative PLR and NLR levels correlated with better clinicopathological features, including decreased depth of invasion, less @entity1600 and early @entity5 stage. Kaplan-Meier plots illustrated that higher pre-operative NLR and PLR had decreased overall survival (OS) and disease-free survival (DFS). @entity5 resection resulted in a significant\linebreak.
