Poor structural social support is associated with an increased risk of XXXX : findings from the MONICA/KORA Augsburg cohort study.

@entity1 @entity308 @entity101 @entity6 @entity285
AIMS: Several psychosocial factors have been shown to increase the risk of @entity6 . This study investigated the association between structural social support and incidence of @entity6 in @entity1 and @entity1 . METHODS: Data were derived from three population-based MONICA/KORA surveys conducted in 1984-1995 in the Augsburg region (southern Germany) and followed up by 2009. The study population comprised 8952 @entity1 (4669 @entity1 /4283 @entity1 ) aged 30-74  years without @entity6 at baseline. Structural social support was assessed using the Social Network Index. Sex-specific hazard ratios were estimated from Cox proportional hazard models. RESULTS: Within follow-up, 904 incident @entity6 cases (558 @entity1 , 346 @entity1 ) were observed. Crude incidence rates for @entity6 per 10  000  @entity1 -years were substantially higher in poor compared with good structural social support ( @entity1 : 94 vs. 69, @entity1 : 58 vs. 43). After adjustment for age, survey, parental history of @entity6 , smoking status, @entity285 intake, physical activity, @entity101 , dyslipidaemia, BMI, education, sleep complaints and @entity308 mood, risk of @entity6 for @entity1 with poor compared with good structural social support was 1.31 [95% confidence interval (CI)  =  1.11-1.55] in @entity1 and 1.10 (95% CI  =  0.88-1.37) in @entity1 . Stratified analyses revealed a hazard ratio of 1.50 (95% CI  =  1.23-1.83) in @entity1 with a low level of education and 0.87 (95% CI  =  0.62-1.22) in @entity1 with a high level of education (P for interaction: 0.0082). CONCLUSIONS: Poor structural social support is associated with @entity6 in @entity1 . This association is independent of risk factors at baseline and is particularly pronounced in @entity1 with a low level of education. This article is protected by copyright. All rights reserved.
