Circulating microparticles in XXXX with sleep disordered breathing.

@entity1 @entity455 @entity409 @entity27 @entity1195 @entity755 @entity1427 @entity9536 @entity731 @entity165
BACKGROUND: @entity409 is a common complication of @entity27 ( @entity27 ). Circulating cell-derived microparticles (MPs) have emerged as reliable biomarkers of @entity409 and @entity731 . METHODS: @entity1 underwent blood drawing the morning after a sleep study. Endothelial function was assessed using a modified hyperemic test after cuff-induced occlusion of the brachial artery. Circulating MP levels in plasma, including levels of endothelial MPs, endothelial progenitor MPs, leukocyte MPs, and platelet MPs, were measured using flow cytometry after staining with cell-specific antibodies. RESULTS: The levels of endothelial MPs, endothelial progenitor MPs, leukocyte MPs, and platelet MPs were significantly different according to the severity of @entity27 in @entity1 . Leukocyte @entity9536 + MPs and platelet CD41a+ MPs correlated with the @entity27 index (AHI) (r = 0.334, P < .001; and r = 0.301, P < .001, respectively), and associations emerged between leukocyte @entity9536 + MPs and @entity755 (r = 0.206, P < .05) and between endothelial MPs and low-density lipoprotein @entity165 (r = 0.240, P < .01). In a multivariate regression model, the BMI z score (b    SE, 0.045    0.020; P = .020) and the @entity1427 a MPs to leukocyte @entity1195 MPs ratio (b    SE, 0.074    0.032; P = .021) were independently associated with peak hyperemic responses. After controlling for age, gender, race, BMI z score, and @entity755 levels, endothelial MPs, endothelial progenitor MPs, and leukocyte MPs showed independent associations with the AHI. Complex significant associations emerged between endothelial function, the AHI, and @entity1427 a MPs. CONCLUSIONS: Childhood @entity27 is associated with higher circulating MP levels that can promote cardiovascular risk. Platelet-derived MPs emerge as being significantly associated with the @entity455 associated with @entity27 in @entity1 and could potentially account for increased risk for altered endothelial function. However, the clinical use of MPs as reliable biomarker indicators of vascular risk will have to await further studies.
