Persistence of polymicrobial abscesses in the poorly controlled XXXX host.

@entity1 @entity2868 @entity6 @entity19 @entity325 @entity526
@entity325 are frequently found in soft tissue infections of the lower extremities in @entity6 @entity1 . The relative susceptibility to and persistence of soft tissue polymicrobial infections of @entity6 and nondiabetic @entity19 using bacteria commonly found in clinical foot infections were studied. Subcutaneous abscesses were induced in three groups of @entity6 and nondiabetic @entity19 using: (1) @entity526 and enterococcus, (2) enterococcus and @entity2868 ( @entity2868 ), and (3) @entity526 and @entity2868 . Abscesses were removed at 1 and 2 wk for total colony counts. At 1 wk, there was a significantly greater bacterial growth in the abscesses of the @entity6 @entity19 compared with the nondiabetic @entity19 only in the group injected with enterococcus and @entity2868 . There were significantly higher colony counts in the @entity6 compared with the nondiabetic @entity19 in all three groups at 2 wk after injection of the bacteria. Two weeks after injection of inocula containing @entity2868 , both in combination with @entity526 or enterococcus, all nondiabetic @entity19 had eradicated @entity2868 from the abscesses, but significant numbers of @entity2868 persisted in the abscesses of the @entity6 @entity19 . In the @entity6 @entity19 , the presence of enterococci was more synergistic for growth of @entity2868 than was the presence of @entity526 . These studies demonstrate that the bacteria of polymicrobial soft tissue infections persist for a longer period of time in the @entity6 compared with the nondiabetic host. In addition, @entity2868 has increased pathogenicity in the @entity6 compared with the nondiabetic host, particularly in the presence of enterococci.
