The result of adjuvant chemotherapy for localized XXXX @entity3484 in a multi-institutional study.

@entity3484 @entity1 @entity1803 @entity5 @entity3 @entity204
PURPOSE: To determine through the analysis of our multi-institutional database whether postoperative adjuvant chemotherapy for @entity3484 with localized invasive @entity3484 ( @entity3484 ) is beneficial. METHODS: A study population of 93 @entity1 with pT3N0/xM0 @entity3484 was eligible for this study. Clinical features evaluated were sex, @entity5 location, adjuvant chemotherapy status, @entity5 pathology (histology, grade, infiltrating growth, @entity3 ( @entity3 )), and cause of @entity204 . Cancer-specific survival (CSS) was estimated by Kaplan-Meier method. Prognostic factors related to CSS were analyzed by Cox proportional hazards regression model for multivariate analysis. RESULTS: In @entity1803 @entity1 , overall 5-year CSS rate was 68.4% and median CSS time was 31 months (range 3-114 months). In the adjuvant chemotherapy group, 5-year CSS rate was 80.8%, whereas 5-year CSS rate was 64.4% in the non-adjuvant chemotherapy group. By multivariate analysis, adjuvant chemotherapy status was significantly associated with CSS (P = 0.008) were sex, @entity5 grade, @entity5 histology, and @entity3 presence. CONCLUSIONS: This study, although it was retrospective study, revealed that adjuvant chemotherapy after RNU may be beneficial in pT3N0/X @entity1 by multivariate analysis. Prospective studies evaluating adjuvant therapy regimens for UTTC are required.
