Outcomes of hepatic resection for a single large XXXX .

@entity1 @entity157 @entity1578
BACKGROUND: The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in @entity1 with a single large @entity157 ( @entity157 ). To evaluate the role of surgical resection in this group of @entity1 , we studied the long-term outcomes of @entity1 that received hepatic resection for a single large (> 5-10 cm in diameter) @entity157 . METHODS: The clinicopathologic data and long-term outcomes of 61 @entity1 with a single large @entity157 (> 5-10 cm in diameter; L group) were compared with those of 169 @entity1 with a single small @entity157 (< or = 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of @entity1578 was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). @entity1 class B was found to predict poor overall and disease-free survival by multivariate analysis versus @entity1 class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups. CONCLUSIONS: Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of @entity1578 . The long-term survival of @entity1 with a single large @entity157 is as good as that of @entity1 with a single small @entity157 . We conclude that hepatic resection is a safe and effective therapy for single large HCCs.
