The effectiveness of local injections of vasodilating agents to produce vasodilation in subcutaneous tissue in XXXX .

@entity1855 @entity4 @entity1854 @entity95 @entity5015 @entity3302 @entity112
The isotope washout method has been widely used to study characteristics of the microcirculation in localized vascular beds. Some of these studies have used local injections of vasodilating agents to maximally dilate the vascular bed. This study was undertaken to determine the agent most effective in producing this critical vasodilation. A @entity95 model was constructed that allowed the study of the subcutaneous blood flow by either 133Xe and 131I-antipyrine washout. Dose-response curves were constructed for five agents. The agents used and the doses that produced the maximum washout rate, were @entity112 (100 micrograms), @entity1855 (0.5 mg), @entity5015 (6 micrograms), @entity3302 (5 mg) and @entity1854 (60 micrograms). The five agents at these doses were compared with each other, and @entity1854 produced a greater washout rate than @entity3302 (P less than 0.005), @entity112 (P less than 0.001) and @entity1855 (P less than 0.005). There was no difference between @entity1854 and @entity5015 (P greater than 0.01). The effect of three of the agents in producing tissue @entity4 was examined by comparing the washout rates values obtained with the two isotopes. Both @entity1854 and @entity3302 produced large @entity4 whereas @entity112 resulted in little @entity4 formation. @entity1854 , therefore, appears to be the most suitable vasodilating agent for use in studies which require maximum vasodilation of localized vascular beds.
