XXXX -induced astrocyte migration and @entity66 formation: effects of magnetic stimulation frequency.

@entity5732 @entity2508 @entity35 @entity66 @entity5611 @entity1711 @entity602 @entity19871 @entity1710 @entity40 @entity1566 @entity19744 @entity130
The effects of magnetic stimulation on @entity1566 -induced migration of white matter astrocytes were studied using an established animal model. @entity5611 was injected into the dorsal spinal cord funiculus of adult @entity35 on the left side at T10-11. Animals then received 1.52 Tesla-pulsed magnetic stimulation for 5 min at different frequencies (0-20 Hz) for 14 consecutive days. Selected animals received the non-competitive @entity19871 inhibitor @entity5732 (10 microM), prior to stimulation at 10 Hz. Lesion volumes were measured in @entity1710 / @entity1711 -stained sections. Expression of @entity40 ( @entity40 ), @entity19744 ( @entity19744 ) and extra-cellular signal-regulated kinasel/2 ( @entity2508 ) near the @entity130 was examined by Western blotting with quantification using an image analysis system. Lesion volumes decreased and @entity40 and p- @entity2508 expression increased with increasing magnetic stimulation frequency (0-10 Hz). @entity19744 expression was not affected at any frequency. Pretreatment with @entity5732 reduced @entity40 and @entity2508 expression and increased lesion volumes in response to stimulation at 10 Hz. It is concluded that magnetic stimulation increases the migration of astrocytes to @entity602 . Activation of the @entity2508 signaling pathway is proposed to mediate astrocyte migration and @entity66 formation in response to @entity1566 .
