Neuroscience-informed Auditory Training in @entity161 : A Final Report of the Effects on Cognition and Serum XXXX .

@entity1 @entity2167 @entity73 @entity161 @entity2252
OBJECTIVE: We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in @entity161 . Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum @entity2252 ( @entity2252 ). METHOD: Eighty-seven clinically stable @entity1 with @entity161 were randomly assigned to either targeted @entity2167 ( @entity2167 , N=46) or a computer games control condition (CG, N=41). @entity1 were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum @entity2252 was assessed at baseline, at 2 weeks, and at 10 weeks. RESULTS: After the intervention, @entity2167 @entity1 showed significant @entity73 , speed of processing, verbal learning, and verbal memory, relative to CG @entity1 , with no changes in symptoms or functioning. At baseline, @entity161 @entity1 had significantly lower-than-normal serum @entity2252 . @entity2167 @entity1 showed a significant increase in serum @entity2252 compared to CG @entity1 , and "normalized" levels by post training. CONCLUSIONS: @entity1 with chronic @entity161 made significant @entity73 after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum @entity2252 levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.
