Effect of Axial Length on Macular Ganglion Cell Complex Thickness and on XXXX Diagnosis by Spectral-Domain Optical Coherence Tomography.

@entity3656 @entity1538 @entity726
PURPOSE: To investigate the effects of the @entity3656 ( @entity3656 )-related ocular magnification on the thickness of the macular ganglion cell complex (mGCC), and the diagnostic accuracy of the built-in normative database of the spectral-domain optical coherence tomographic (SD-OCT) instrument for @entity726 detection. METHODS: This retrospective study included 41 eyes with early primary @entity1538 and 36 normal eyes. The mGCC thickness within a 20-degree circle, equivalent to a 6 mm diameter in the Gullstrand model eye, was measured in the SD-OCT images. The magnification effect was corrected using Bennett formula, and the mGCC thickness within the actual 6 mm diameter circle was determined. RESULTS: In normal eyes, the inferior corrected mGCC was significantly correlated with the @entity3656 (b=-0.40, P=0.028), but correction for the magnification reduced the correlation. In 38 nonhighly myopic eyes, the sensitivity and specificity of the SD-OCT's significance maps for distinguishing @entity726 were 95.0% and 94.4% when using either the uncorrected or the corrected mGCC. In 39 highly myopic eyes, the diagnostic accuracy was lower when using the uncorrected mGCC thickness (sensitivity was 95.2% and specificity was 44.4%), and was not improved when using the corrected mGCC (81.0% and 61.1%, respectively). CONCLUSIONS: The inferior mGCC was thinner in eyes with longer @entity3656 . The accuracy of the diagnosis with the SD-OCT built-in normative database for @entity726 was not improved significantly by the correction of the @entity3656 -associated magnification in highly myopic eyes. Evaluation of highly myopic eyes with the nonhighly myopic normative database can lead to misdiagnosis.
