Bone mineral density and @entity731 : the Multi-Ethnic Study of XXXX , Abdominal Aortic Calcium Study.

@entity1 @entity650 @entity24671 @entity101 @entity2299 @entity167 @entity6 @entity1255 @entity2998 @entity4435 @entity731 @entity121
CONTEXT: Molecular and cell biology studies have demonstrated an association between bone and arterial wall disease, but the significance of a population-level association is less clear and potentially confounded by inability to account for shared risk factors. OBJECTIVE: To test population-level associations between @entity731 types and bone integrity. MAIN OUTCOME MEASURES: Volumetric trabecular lumbar bone mineral density (vBMD), ankle-brachial index (ABI), @entity121 ( @entity121 ) of the common carotid ( @entity4435 ) and internal carotid (ICA- @entity121 ) arteries, and carotid plaque echogenicity. DESIGN, SETTING AND @entity1 : A random subset of @entity1 from the Multi-Ethnic Study of @entity731 (MESA) assessed between 2002 and 2005. RESULTS: 904 post-menopausal female (62.4 years; 62% non-white; 12% @entity24671 ; 17% @entity4435 >1mm; 33% ICA- @entity121 >1mm) and 929 male (61.4 years; 58% non-white; 6% @entity24671 ; 25% @entity4435 >1mm; 40% ICA- @entity121 >1mm) were included. In serial, sex-specific regression models adjusting for age, ethnicity, body mass index, @entity2299 , @entity101 , smoking, @entity167 consumption, @entity6 , @entity1255 , @entity650 , sex hormones, and renal function, lower vBMD was associated with lower ABI in @entity1 (p for trend <0.01) and greater ICA- @entity121 in @entity1 (p for trend <0.02). @entity4435 was not associated with vBMD in @entity1 or @entity1 . Carotid plaque echogenicity was independently associated with lower vBMD in both @entity1 (trend p=0.01) and @entity1 (trend p<0.04). In all models, adjustment did not materially affect results. CONCLUSIONS: Lower vBMD is independently associated with structural and functional measures of @entity731 in @entity1 and with more advanced and calcified @entity2998 in both sexes.
