Pial arterial and venous reaction to intravenous infusion of @entity3931 in XXXX .

@entity3931 @entity468 @entity551 @entity460
The @entity460 -antagonist @entity3931 was infused intravenously in ten @entity468 using dosage rates of 0.5 to 3 micrograms kg-1 min-1. The reactions of pial arterial and venous vessels as well as @entity551 ( @entity551 ) were studied. For analysis of pial vascular reactions, diameter variations were continuously monitored on 50 arterial and 22 venous portions using a multichannel videoangiometer. At 0.5 micrograms kg-1 min-1, pial arteries with a mean resting diameter of 81 microns dilated by 4% (p less than 0.0005); venous diameters decreased by 0.5% (n.s.); @entity551 declined by 2% (n.s.). At 1 microgram kg-1 min-1, arteries dilated by 25% (p less than 0.0005), venous diameters were diminished by 3.8% (n.s.), @entity551 decreased by 9% (n.s.). Further significant dilatation of pial arteries was observed at 2 and 3 micrograms kg-1 min-1, however, together with a significant fall of @entity551 . Arterial vessels smaller than 60 micrograms resting diameter dilated more than arteries above 60 micrograms. After the infusion was stopped, arterial dilatation by some 20% persisted for at least 20 minutes, even when @entity551 values returned to the resting level.
