XXXX , sex hormones, and inflammatory markers in older @entity1 .

@entity1 @entity32 @entity251 @entity1851 @entity650 @entity6 @entity310 @entity102 @entity53 @entity443
CONTEXT: In premenopausal and older @entity1 , high @entity251 and @entity53 (E2) and low @entity443 levels are associated with insulin resistance and @entity6 , conditions characterized by low-grade @entity32 . OBJECTIVE: The aim of the study was to examine the relationship between @entity443 , total @entity251 , total E2, and inflammatory markers in older @entity1 . DESIGN AND @entity1 : We conducted a retrospective cross-sectional study of 433 @entity1 at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement therapy or recently hospitalized and who had complete data on @entity443 , @entity251 , E2, @entity1851 ( @entity1851 ), @entity650 , soluble @entity650 receptor (sIL-6r), and @entity310 . Relationships between sex hormones and inflammatory markers were examined by multivariate linear regression analyses adjusted for age, body mass index, smoking, insulin, physical activity, and @entity102 . RESULTS: In fully adjusted analyses, @entity443 was negatively associated with @entity1851 (P = 0.007), @entity650 (P = 0.008), and sIL-6r (P = 0.02). In addition, @entity251 was positively associated with @entity1851 (P = 0.006), @entity650 (P = 0.001), and @entity310 (P = 0.0002). The negative relationship between @entity251 and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with @entity1851 (P = 0.002) but not with @entity650 in fully adjusted models. In a final model including E2, @entity251 , and @entity443 , and all the confounders previously considered, @entity443 (0.23    0.08; P = 0.006) and E2 (0.21    0.08; P = 0.007), but not @entity251 (P = 0.21), were still significantly associated with @entity1851 . CONCLUSION: In late postmenopausal @entity1 not on hormone replacement therapy, @entity443 and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state.
