A long-term follow-up study of severe variant of XXXX .

@entity1 @entity2194 @entity1713 @entity2318 @entity1252 @entity3202 @entity2118 @entity989 @entity792
PURPOSE: To facilitate understanding of the long-term course and visual outcome of a severe variant of @entity989 . DESIGN: Consecutive observational case series. @entity1 AND METHODS: The authors reviewed 25 @entity1 with multifocal @entity2118 and bullous @entity1713 , who had a mean follow-up time of 10.6 years (range, 6-22 years), with reference to the demographic feature, fundus changes, recurrence, and final anatomic and visual outcome. Two @entity1 underwent optical coherence tomography. RESULTS: The @entity1 were 21 @entity1 and 4 @entity1 , with a mean age at disease onset of 43.1 years (range, 30-63 years). Twenty-one @entity1 were otherwise healthy, and four developed @entity2194 during systemic corticosteroid therapy for metabolic or @entity792 including @entity1252 . The disease was bilateral in 21 @entity1 (84%). Nine @entity1 (36%) presented initially with classic @entity989 , followed by its severe variant 7 months to 9 years later. Active disease was characterized by multifocal exudative lesions in the posterior pole and bullous @entity1713 with shifting subretinal fluid in the inferior periphery. Optical coherence tomography of exudative lesions disclosed cloudy and fibrinous subretinal fluid. The exudative lesions were self-limited or responded to photocoagulation. During the follow-up period, 13 @entity1 (52%) showed 1 to 5 recurrent disease, but the disease eventually became quiescent with multifocal @entity2318 in the posterior pole with or without @entity3202 tracts in the inferior periphery. Final best-corrected visual acuity was 2020 or better in 24 of 46 affected eyes (52%) of 25 @entity1 and 2040 or better in 37 eyes (80.4%). CONCLUSIONS: A severe variant of @entity989 characterized by multifocal posterior exudations and bullous inferior @entity1713 with shifting subretinal fluid may affect otherwise healthy, middle-aged males or individuals receiving systemic corticosteroid therapy for metabolic or @entity792 . Exudative chorioretinal lesions are self-limited or respond to photocoagulation. Recurrence is common, but the disease eventually becomes quiescent with favorable visual acuity unless the macula is damaged.
