Partial splenectomy for XXXX : a multi-institutional review.

@entity1 @entity295 @entity417 @entity7276 @entity648 @entity490
BACKGROUND/PURPOSE: Partial splenectomy has emerged as a surgical option for selected @entity1 with @entity7276 , with the goal of reducing @entity417 while preserving splenic function. This multi-institutional study is the largest series to date examining outcomes data for partial splenectomy in @entity1 with @entity7276 . METHODS: Data were collected retrospectively from 5 North American pediatric hospitals. Sixty-two @entity1 underwent partial splenectomy for @entity7276 between 1990 and 2008. RESULTS: At 1 year following partial splenectomy, mean hemoglobin significantly increased by 3.0    1.4 g/dL (n = 52), reticulocyte count decreased by 6.6%    6.6% (n = 41), and @entity648 level decreased by 1.3    0.9 mg/dL (n = 25). @entity1 with poor or transient hematologic response were found to have significantly more splenic regeneration postoperatively compared with @entity1 with a durable clinical response (maximal spleen dimension, 9.0    3.4 vs 6.3    2.2 cm). Clinically significant recurrence of @entity417 or @entity490 led to completion splenectomy in 4.84% of @entity1 . No @entity1 developed @entity295 . CONCLUSIONS: Our multi-institutional review indicates that partial splenectomy for @entity7276 leads to sustained and clinically significant improvement in hematologic profiles and clinical symptoms in most @entity1 . Our data support partial splenectomy as an alternative for selected @entity1 with @entity7276 .
