Substrate concentration changes during pregnancy in the XXXX studied under unstressed steady state conditions.

@entity4323 @entity840 @entity4322 @entity1017 @entity880 @entity1718 @entity9031 @entity413 @entity2388
@entity1017 and food intake were measured in unstressed nonpregnant and pregnant @entity840 fed ad libitum. Nonpregnant females consumed 33.2 +/- 0.5 g.day-1 of pellet diet and did not demonstrate a consistent pattern of @entity1017 . The average daily food intake of pregnant animals increased linearly from 38 g.day-1 at 27 days to over 60 g.day-1 near term, and the average maternal @entity1017 was 13.3 g.day-1. Using sterile technique, @entity9031 catheters were inserted under anesthesia into the carotid and femoral arteries of these animals. Animals recovered spontaneously, and catheters remained patent for up to 4 wk. The effect of surgical and anesthetic stress was evaluated by measurement of food intake and metabolite levels after surgery. In the nonpregnant animals, blood @entity413 decreased immediately after surgery (4.76 +/0- 0.36 versus 5.65 +/- 0.25; P less than 0.05), whereas the pregnant animals responded with a substantial increase in blood @entity413 (7.57 +/- 0.48 versus 5.87 +/- 0.33; P less than 0.05). @entity880 was increased intraoperatively in both groups (1.76 +/- 0.22 versus 1.11 +/- 0.07, nonpregnant; 1.80 +/- 0.17 versus 1.10 +/- 0.08, pregnant). The pregnant animals differed from the nonpregnant animals with regard to the pattern of changes in blood ketones after surgery. The nonpregnant animals achieved steady state within 1 day after surgery, whereas the pregnant animals required 4 days for recovery. Food intake and maternal @entity1017 were markedly reduced during the recovery period for the pregnant animals. Blood metabolite levels were measured in well-fed, unstressed pregnant and nonpregnant @entity840 . Using measurements made after the third postoperative day, the unstressed pregnant animals demonstrated a progressive decline in blood @entity413 levels, reaching levels significantly below those of nonpregnant animals at 55 to 60 and 60+ days. Arterial concentrations of @entity880 , @entity2388 , @entity4322 , @entity4323 , and free @entity1718 did not change consistently with gestation and were not significantly different from nonpregnant values.
