Effects of the @entity1245 antagonist @entity5757 on postoperative performance following total intravenous anaesthesia with XXXX and @entity680 .

@entity1 @entity680 @entity2730 @entity2147 @entity1245 @entity4490 @entity148 @entity5757 @entity3810 @entity1363
Postoperative performance following total intravenous anaesthesia (TIVA) using @entity1363 and @entity680 was studied with and without the administration of a single dose of a @entity1245 antagonist, @entity5757 (Ro 15-1788). Performance was compared with a reference group anaesthetized with @entity4490 , @entity680 and @entity3810 . All @entity1 were assessed by use of a rating scale which took into account the degree of sedation, @entity2730 , comprehension and cooperation as well as temporal and spatial orientation. There was a slow recovery following TIVA with @entity2147 and @entity2730 lasting several hours. Administration of @entity5757 1.0 mg i.v. at extubation caused a significant reduction of sedation (P less than 0.001) during the first postoperative hour, with @entity1 fully awake or only lightly sedated, but was later followed by resedation. The @entity1 of the reference group were moderately sedated during the observation period. Five and six hours postoperatively there was no difference between the groups. @entity2730 was more profound in the groups that received @entity1363 ; the effect of the antagonist could only be seen for 15 min after its administration. Comprehension and cooperation, as well as orientation, were equally good in the antagonist and in the reference group during the immediate postoperative period, whereas in the TIVA group a gradual improvement over the first hours was seen. In the antagonist group there was no increase in the number of analgesic requirements, no @entity148 or other adverse effects. It is concluded that @entity5757 offers an improvement in postoperative performance following TIVA induced by @entity1363 and @entity680 , but the effects are of short duration.
