OS047. Quantification of placental vascularization in a XXXX model ofIUGR with three-dimensional power doppler angiography.

@entity5028 @entity95 @entity1592 @entity1468 @entity842 @entity393 @entity6462 @entity5327
INTRODUCTION: @entity5028 is known to be a major cause of pregnancy complications, such as @entity393 , @entity1468 , and @entity1592 ( @entity1592 ). Inadequate remodeling of the spiral arteries resulting in decreased blood flowto the placenta has been implicated in the pathophysiology of @entity1468 and @entity1592 . 3D power Doppler angiography (PDA) is a noninvasive and safe way to study blood flow within an organ or region of interest. The aim of this study was to evaluate PDA as a method to quantify placental perfusion in a pharmacological @entity95 model of vascular @entity1592 induced by inhibition of NO synthesis. OBJECTIVES: Our objective was to evaluate the 3D power Doppler angiography (PDA) in terms of feasibility and ability to detect placental hypo-perfusion in an experimental @entity95 model of @entity1592 ( @entity1592 ). METHODS: Fourteen pregnant females were treated with @entity6462 ( @entity6462 ), a @entity842 synthase inhibitor, from day 24 to day 28 of gestation, to induce an @entity1592 . Concomitantly, 8 pregnant @entity95 were used as controls. On day 28, 3D power Doppler indices were quantified in each uteroplacental unit. RESULTS: A total number of 180 live fetuses were obtained, 180 from the @entity6462 group and 72 from the control group. G28 fetal weight was significantly lower in the @entity6462 group than in the control group (27.40  0.55g vs 33.14  0.62g,p<0.0001). In the @entity6462 group the vascularization index (VI) was significantly lower than in the control group (2.6 [1.4;6.0] vs 7.6 [3.5;12.6],p<0.05). Similar results were obtained for the Flow Index (FI) and the Vascularization Flow Index (VFI). The number of fetuses considered as small for gestational age (SGA;weight<10th centile) was significantly higher in the @entity6462 group than in the control group (47/108 vs 7/72,p<0.0001). The VI was significantly lower in the SGA group than in the eutrophic group (3.46 [0.46;5.9] vs 7.50 [4.22;10.9] p<0.05). Similar results were obtained for FI and VFI. CONCLUSIONS: This experiment study demonstrates that quantitative 3D PDA indices are sensitive enough to detect placental @entity5327 in an experimental model of @entity1592 .
