Hepatic and metabolic changes in surgical colic XXXX : a pilot study.

@entity1 @entity5428 @entity1641 @entity3265 @entity5121 @entity648 @entity412 @entity6741 @entity413
OBJECTIVE: To determine: (1) changes in blood @entity3265 , @entity6741 (BA), @entity648 , @entity412 , and @entity413 concentrations and liver enzyme activities in perioperative colic @entity1 and (2) the association between these laboratory findings and short-term survival. DESIGN: Prospective observational clinical study. ANIMALS: Thirty-two adult @entity1641 undergoing exploratory celiotomy for colic. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Blood samples were collected preoperatively and at 24-36 and 72-84 hours postoperatively and analyzed for blood @entity3265 , BA, @entity648 , @entity412 , and @entity413 concentrations and @entity5121 dehydrogenase (SDH) and @entity5428 transferase (GGT) activities. Short-term survival was defined as survival to hospital discharge. Data were analyzed using a Fisher's exact test and analysis of variance. Mildly increased blood @entity3265 concentrations were present in 2 @entity1641 at admission. Postoperative blood @entity3265 concentrations were within reference intervals in all @entity1641 . There were increases in liver enzyme activities as well as in BA, @entity412 , and total @entity648 concentrations. @entity1641 with markedly increased admission BA concentrations and SDH activities did not survive. BA concentrations and SDH activities decreased postoperatively. There was no association between GGT activity and survival; GGT activity remained increased postoperatively. Blood @entity412 concentration was increased in almost all @entity1641 postoperatively; @entity1641 that did not survive had higher @entity412 concentrations at 24-36 hours postoperatively than @entity1641 that survived. CONCLUSION: Alterations in metabolism and hepatobiliary function are common in colic @entity1 . The results of this study provide further prognostic indices for colic @entity1 and highlight areas for improvement in @entity1 management.
