Genome-wide linkage scan for the XXXX in the HERITAGE Family Study.

@entity1 @entity13704 @entity6 @entity25900 @entity164 @entity209 @entity65
The @entity209 involves multiple and interactive effects of genes and environmental factors. To identify chromosomal regions encoding genes possibly predisposing to the @entity209 , we performed a genome-wide scan with 456 white and 217 black @entity1 from 204 nuclear families of the HERITAGE Family Study, using regression-based, single- and multipoint linkage analyses on 509 markers. A principal component analysis was performed on 7 @entity209 -related phenotypes. Two principal components, @entity13704 and @entity25900 (55% of the variance), were used as @entity209 phenotypes. ANOVA was used to quantify the familial aggregation of @entity13704 and @entity25900 . Family membership contributed significantly (P < 0.0023) to the variance in @entity13704 (r(2) = 0.38 in whites; r(2) = 0.55 in blacks) and @entity25900 (r(2) = 0.51; r(2) = 0.48). In whites, promising evidence for linkage (P < 0.0023) was found for @entity13704 (2 markers on 10p11.2) and @entity25900 (a marker on 19q13.4). Suggestive evidence of linkage (0.01 > P > 0.0023) appeared for @entity13704 (1q41 and 9p13.1) and @entity25900 (2p22.3). In blacks, promising linkage was found for @entity25900 on 1p34.1, and suggestive linkage was found on 7q31.3 and 9q21.1. The genome-wide scan revealed evidence for quantitative trait loci on chromosomal regions that have been previously linked with individual @entity65 and @entity164 2 @entity6 risk factors. Some of these chromosomal regions harbor promising potential candidate genes.
