Outcome after laparoscopic radiofrequency ablation of technically resectable XXXX .

@entity1 @entity5 @entity14
BACKGROUND: There continues to be controversy surrounding the appropriate use of radiofrequency ablation (RFA) for the treatment of @entity14 ( @entity14 ). This study analyzes outcomes data of @entity14 @entity1 who underwent laparoscopic RFA. Outcomes of @entity1 determined to be technically resectable were compared to @entity1 with unresectable disease. METHODS: Data from all @entity1 with @entity14 who underwent laparoscopic RFA between 1996 and 2006 were retrospectively reviewed. A blinded independent hepatobiliary-trained surgical oncologist reviewed preoperative diagnostic imaging studies to determine resectability. Outcomes data for @entity1 with disease deemed anatomically resectable and unresectable were analyzed and compared. Survival was calculated by the Kaplan-Meier method. The log rank test was performed to assess significance in survival. RESULTS: A total of 113 @entity1 who underwent laparoscopic RFA for @entity14 were identified. Twelve @entity1 who underwent concurrent hepatic resection were excluded. Of the remaining @entity1 , 64 were determined to have disease that was be technically resectable and 37 unresectable as a result of @entity5 number and/or distribution. Median and 5-year survival of the potentially resectable group was 4.3years and 48.7%, compared to 2.2 years and 18.4% in the unresectable group (P = 0.002). Median disease-free survival in the resectable group was 15.0 months, compared to 16.4 months in the unresectable group (P = 0.796). No postoperative mortality was reported in the technically resectable group, and the rate of major complications was 3.1%. CONCLUSIONS: Laparoscopic RFA of resectable @entity14 can produce comparable long-term survival to hepatic resection in carefully selected @entity1 , with favorable morbidity and mortality.
