Acanthopanax senticosides B ameliorates oxidative damage induced by XXXX in cultured neonatal rat cardiomyocytes.

@entity274 @entity66 @entity27517 @entity3857 @entity2041 @entity2197 @entity273 @entity1234 @entity880 @entity12609 @entity224 @entity1865
Acanthopanax senticosides B is a monomer of @entity27517 @entity3857 . Previous reports showed that @entity27517 saponins exhibit antioxidant action and cardiac protection. However, whether Acanthopanax senticosides B has cardiac protection remains unknown. In this study, we investigated the effect of Acanthopanax senticosides B on oxidative damage induced by @entity273 ( @entity274 ) of cardiomyocytes. As revealed from the results, when the cardiomyocytes were exposed to @entity274 for designed time and concentration, the percentage of survival cells was down significantly, the activity of @entity880 dehydrogenase (LDH) and the content of cellular @entity1234 ( @entity1865 ) were increased markedly. These results indicated that the cells were subjected to oxidative damage. Treatment with Acanthopanax senticosides B prior to @entity274 (100 microM) exposure can increase cell viability significantly, lessen @entity274 -induced cardiomyocyte morphological change, and inhibit augmentation of LDH activity in culture media and cellular @entity1865 content markedly. Our results demonstrated that Acanthopanax senticosides B (400 microg/ml and 200 microg/ml) can protect cells against oxidative injury of @entity274 (100 microM). Furthermore, the activities of @entity224 dismutase (SOD), @entity2041 peroxidase, @entity12609 and the content of @entity2041 ( @entity2197 ) of cardiomyocytes were also raised by Acanthopanax senticosides B. Taken together, the study implicated that Acanthopanax senticosides B protects cardiomyocytes against @entity66 induced by @entity274 through reduction of lipid peroxidation and enhancement of the activity of antioxidant defense.
