Female gender: an independent factor in XXXX .

@entity1 @entity712 @entity301 @entity583 @entity204 @entity65
INTRODUCTION: @entity65 is the leading cause of @entity204 in @entity1 . In @entity583 ( @entity583 ) in particular, the question has been raised whether specific characteristics of @entity1 confer a worse prognosis. OBJECTIVE: To evaluate the differences in @entity583 @entity1 between the genders in cardiovascular risk profile, clinical presentation, therapeutic approach and in-hospital and 6-month mortality rates. METHODS: We analyzed 1578 @entity1 admitted consecutively with @entity583 during a 7-year period (from January 13, 2002 to December 31, 2008). The @entity1 were divided into two groups according to gender, and compared in terms of baseline clinical and demographic characteristics, pre-hospital and in-hospital delay, clinical presentation on admission, reperfusion therapy, severity of @entity301 and in-hospital and 6-month mortality. RESULTS: Of the 1578 @entity1 , 26% were female. @entity1 were older (by 8 years), and had a higher cardiovascular risk profile. On admission, their clinical presentation was more severe, with a higher frequency of @entity583 and @entity712 . @entity1 had longer ischemic times and lower rates of reperfusion therapy. Mortality in @entity1 was significantly higher than in @entity1 , both in-hospital (17.5 vs. 5.3%) and at 6 months (23.5% vs. 8.2%). After adjustment in multivariate analysis, mortality in @entity1 remained higher. CONCLUSIONS: The adverse demographic and clinical profile could partially explain the worse prognosis of @entity583 in @entity1 . This, together with longer pre-hospital delays, led to underuse of reperfusion therapy. Even so, female gender by itself had a negative and independent influence on mortality in @entity583 @entity1 .
