@entity323 and risk of XXXX requiring dialysis: a nationwide population-based study.

@entity407 @entity1 @entity323 @entity101 @entity66 @entity6 @entity301 @entity454
BACKGROUND: Previous studies have suggested that @entity323 ( @entity323 ) is an independent risk factor for @entity66 . Very few studies have evaluated the relationship between @entity323 and risk of @entity454 ( @entity454 ) requiring dialysis. METHODS: A random sample of 1,000,000 individuals from Taiwan's National Health Insurance database was collected. We selected the control group by matching the subjects and controls by age, @entity6 , @entity101 , @entity301 , @entity407 , area of residence, monthly income and index date. We identified 3985 @entity1 with newly-diagnosed @entity323 between 2000 and 2008 and compared them with a matched cohort of 23910 @entity1 without @entity323 . All @entity1 were tracked from the index date to identify which @entity1 subsequently developed a need for dialysis. RESULTS: The incidence rates of dialysis in the @entity323 cohort and comparison groups were 10.85 and 9.06 per 10000 @entity1 -years, respectively. Stratified by age, the incidence rate ratio for dialysis was greater in @entity323 @entity1 aged <50 years (3.16, 95% CI: 1.62-6.19, p = 0.0008) but not in aged 50-64 (0.94, 95% CI: 0.52-1.69, p = 0.8397) and those aged     65 (0.69, 95% CI: 0.32-1.52, p = 0.3594). After adjustment for @entity1 characteristics and medial comorbidities, the adjusted HR for dialysis remained greater in @entity323 @entity1 aged <50 years (adjusted HR: 2.08, 95% CI: 1.05-4.11, p<0.05). The log-rank test revealed that @entity323 @entity1 <50-years-old had significantly higher cumulative incidence rates of dialysis than those without (p = 0.0004). CONCLUSION: @entity1 with @entity323 , especially younger @entity1 , are at an increased risk for @entity454 requiring dialysis later in life.
