Clara cell 10-kDa protein expression in XXXX and its cytokine-driven regulation in sinonasal mucosa.

@entity1 @entity10974 @entity1356 @entity310 @entity565 @entity102 @entity688 @entity3646 @entity480 @entity7457
BACKGROUND: Clara cell 10-kDa protein ( @entity10974 ) is a multifunction protein with anti-inflammatory and immunomodulatory effects; hence we compared the @entity10974 expression between @entity102 ( @entity102 ) @entity1 with and without @entity480 ( @entity480 ), analyzed its association with disease severity and response to surgery, and explored its regulation via cytokines. METHODS: The plasma and tissue @entity10974 levels were compared between controls and @entity102 @entity1 with and without @entity480 by means of quantitative RT-PCR, ELISA, and immunohistochemistry. Computed tomography (CT) scan and endoscopy findings and symptoms were scored. Nasal explant culture was used to explore the effect of @entity310 , @entity1356 , @entity3646 , INF-gamma, and @entity688 on @entity10974 gene regulation. RESULTS: Compared with controls, the @entity10974 expression in sinonasal mucosa was significantly inhibited in both @entity102 @entity1 with and without @entity480 . There was a significant further decrease of @entity10974 expression in @entity1 with @entity480 and @entity565 . No difference in @entity10974 plasma levels was found between controls and @entity1 . @entity10974 levels inversely correlated with preoperative CT scores, and postoperative endoscopy and symptom scores. @entity310 , @entity1356 and @entity3646 inhibited, whereas INF-gamma and @entity688 promoted @entity10974 production in nasal mucosa. A significantly faster decay of @entity10974 transcripts was seen after @entity1356 treatment. @entity1356 and @entity688 induced @entity7457 expression. INF-gamma increased, whereas @entity3646 inhibited hepatocyte nuclear factor-3alpha expression. CONCLUSION: @entity10974 may take part in the pathogenesis of @entity102 and correlates with disease severity and response to surgery. Different cytokines can regulate @entity10974 expression in nasal mucosa differentially through modulating mRNA stability and certain transcriptional factors expression.
