Clinical characteristics and prognostic factors of XXXX with mature T-cell @entity706 : a single-institution study of 225 cases.

@entity1 @entity1071 @entity706 @entity1442 @entity880 @entity6393 @entity1349
UNASSIGNED: Mature T-cell @entity706 comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell @entity706 compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 @entity1 with mature T-cell @entity706 treated in a single institution. These included 29 cases of @entity1071 ( @entity1071 , all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year @entity1349 ( @entity1349 ) rates of @entity1071 and T/NKCL were 96.6% and 37.3%, respectively. @entity1071 @entity1 were less likely to exhibit poor performance status, @entity1442 stage, presence of B symptoms, or abnormal level of serum @entity6393 . With similar pathological characteristics, T/NKCL @entity1 with BM infiltration showed significantly lower response rates and shorter @entity1349 than those without BM infiltration (P = 0.0264 and P < 0.0001, respectively). Multivariate analysis indicated that poor performance status, @entity1442 stage, elevated serum @entity880 dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying @entity1 with mature T-cell @entity706 .
