Arterial @entity385 risk factors: the International Pediatric XXXX Study.

@entity1 @entity135 @entity64 @entity4065 @entity281 @entity1188 @entity299 @entity731 @entity385
OBJECTIVE: To describe presumptive risk factors (RFs) for childhood @entity385 ( @entity385 ) and explore their relationship with presentation, age, geography, and @entity1188 characteristics. METHODS: @entity1 (29 days-18 years) were prospectively enrolled in the International Pediatric @entity64 Study. Risk factors, defined conditions thought to be associated with childhood @entity385 , were divided into 10 categories. Chi-square tests were used to compare RFs prevalence across regions and age; logistic regression was used to determine whether RFs were associated with particular features at presentation or @entity1188 characteristics. RESULTS: A total of 676 @entity1 were included. No identifiable RFs was present in 54 (9%). RFs in others included @entity4065 (53%), @entity299 ( @entity299 ) (31%), @entity281 (24%), @entity135 ( @entity135 ) (23%), acute systemic conditions (ASCs) (22%), chronic systemic conditions (CSCs) (19%), prothrombotic states (PTSs) (13%), @entity135 ( @entity135 ) (10%), @entity731 -related RFs (2%), and other (22%). Fifty-two percent had multiple RFs. There was lower prevalence of @entity4065 in Asia, lower prevalence of CSCs in Europe and Australia, higher prevalence of PTSs in Europe, and higher prevalence of ASCs in Asia and South America. Prevalence of @entity299 and ASCs was highest in preschoolers, @entity4065 in @entity1 5 to 9 years old, and @entity135 were highest in @entity1 aged 10 to 14 years. Arteriopathies were associated with focal signs and ASCs, @entity135 , and @entity135 with diffuse signs. Arteriopathies, CSCs, and ASCs were associated with @entity1188 and @entity299 with hemorrhagic conversion. INTERPRETATION: RFs, especially @entity4065 , are common in childhood @entity385 . Variations in RFs by age or geography may inform prioritization of investigations and targeted preventative strategies.
