Human leukocyte antigen-DRB1 polymorphism in childhood XXXX .

@entity1 @entity981 @entity5 @entity792 @entity1533
UNASSIGNED: Similar to @entity792 , there are clear associations between resistance or susceptibility to @entity5 and the classic human leukocyte antigen (HLA) profile of an individual. HLA-associated susceptibility to childhood @entity981 ( @entity981 ) may provide clues to leukemogenesis in general and to the role of other risk factors. The present study aimed to determine the association between the @entity1533 genotype and susceptibility to @entity981 in @entity1 and to assess the prognostic value of @entity1533 alleles in these @entity1 . This study included 50 @entity981 @entity1 who were consecutively admitted to the Pediatric Oncology Unit of Zagazig University Hospital and 50 gender-matched healthy volunteers as a control group. The @entity1 were subjected to full clinical history, thorough clinical examination and routine laboratory investigations. Molecular @entity1533 typing for @entity1 and controls using the reverse sequence-specific oligonucleotide probe technique was performed. @entity1533 *04 allele frequency was significantly higher in female @entity1 compared to that in female controls (P=0.03) and in @entity1 aged <10 years compared to those aged >= 10 years at the time of diagnosis (P=0.01). @entity1533 *11 allele frequency was significantly higher in high-risk compared to standard-risk @entity1 (P=0.01) and in refractory @entity1 compared to those who achieved remission (P=0.02). In conclusion, the @entity1533 *04 allele appears to be a female-specific susceptibility factor for the acquisition of @entity981 and it may affect the age of onset of @entity981 . In addition, the @entity1533 *11 allele may be of prognostic significance in @entity981 . However, further larger studies are required to support the conclusions drawn from this study.
