Evaluation of the factors affecting the maximum standardized uptake value of metastatic lymph nodes in different histological types of XXXX on PET-CT.

@entity1 @entity5 @entity957 @entity1149 @entity3 @entity420
BACKGROUND: To evaluate the factors affecting the maximum standardized uptake value (SUVmax) of metastatic lymph nodes in different histological types of @entity1149 ( @entity1149 ) on integrated positron emission tomography and computed tomography (PET-CT). METHODS: This was a retrospective, single-institution review of 122 @entity1 with pathologically proven @entity1149 who had PET-CT scanning at the same center. Lymph node @entity3 were pathologically confirmed in tissue specimens from surgical @entity1 . Statistical evaluation of PET-CT results was performed on a per-nodal-station basis. RESULTS: The @entity5 SUVmax of @entity957 ( @entity957 ) (11.0        4.1) was higher than that of @entity420 ( @entity420 ) (7.4        4.4) (P   <   0.01), however, the SUVmax of the metastatic lymph nodes did not differ between the @entity957 (4.6        3.1) and @entity420 groups(3.6        2.5) (P   =   0.221). The SUVmax of metastatic lymph nodes was positively correlated with lymph node size but not with the @entity5 SUVmax, @entity5 size, @entity5 location and @entity5 differentiation. The frequency of a SUVmax of lymph nodes >= 2.5 was 44%, 80%,100% in @entity957 group and 39%, 59%, 90% in @entity420 group when the short-axis diameter of metastatic lymph node was <10  mm, 10-15  mm, and   >   15  mm, respectively. The low sensitivity for metastatic lymph nodes on PET-CT was increased when the SUVmax cut-off for @entity5 was considered to be above the normal background compared with that when the SUVmax cut-off was above 2.5. CONCLUSIONS: There was no difference in the SUVmax of metastatic lymph nodes in the @entity957 and @entity420 groups. The SUVmax of metastatic lymph nodes was positively correlated with metastatic lymph node size. There was a high false negative rate if lymph nodes with a short-axis diameter less than 10  mm and a extremely low false negative rate if lymph nodes with a short-axis diameter higher than 15  mm. Although an increased sensitivity may be achieved by decreasing the SUVmax cut-off, invasive staging may still be required for negative lymph nodes due to the lower sensitivity of PET-CT in both @entity957 and @entity420 .
