The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in XXXX .

@entity1 @entity32 @entity3785 @entity1569 @entity5656 @entity13880 @entity1968
BACKGROUND: Psoriasis lesions accumulate @entity13880 ( @entity13880 ) with a variable distribution within plaques due to variations in @entity5656 causing differences in penetration of cream or light. OBJECTIVES: To study the effects of different keratolytic pretreatments in PpIX-induced fluorescence diagnosis (FDAP) and during photodynamic therapy (PDT). METHODS: Two @entity1569 plaques of 10 @entity1 were treated with either topical @entity1968 or with a hydrocolloid dressing. The hydrocolloid dressing gave the best results. Subsequently, two different contralateral plaques of eight @entity1 were pretreated with a hydrocolloid dressing or the standard pretreatment, @entity3785 in petrolatum, during the 6 weeks of PDT. Biopsies were investigated with respect to stratum corneum thickness, proliferation, differentiation and @entity32 . RESULTS: Irritation and point bleedings were noticed after @entity1968 . A hydrocolloid dressing induced the best clinical improvement. Therefore, it was used as alternative pretreatment for @entity1569 prior to PDT. We observed significant clinical and immunohistochemical improvement of @entity1569 in the @entity3785 as well as the hydrocolloid dressing pretreated plaques. CONCLUSIONS: @entity3785 in petrolatum and a hydrocolloid dressing prior to FDAP and PDT induce improvement of @entity5656 . Thus, a hydrocolloid dressing is a good alternative to the current keratolytic pretreatment regime.
