Surveillance for second primary XXXX after adjuvant chemotherapy: an analysis of Intergroup 0089.

@entity1 @entity1127 @entity5 @entity6523 @entity14 @entity694 @entity1487
BACKGROUND: The incidence of second primary @entity14 in @entity1 with a history of @entity694 , compared with @entity1 with a history of @entity6523 , is unknown. It is unclear whether guidelines for colonoscopy screening in @entity1 with @entity1127 are appropriate for @entity1 with previous @entity694 . OBJECTIVE: To determine the incidence of second primary @entity14 after treatment for localized @entity694 and to compare this incidence with that of first primary @entity14 in both the general population and high-risk @entity1 . DESIGN: Historical cohort study. SETTING: An international, multi-institutional trial of adjuvant @entity1487 -based chemotherapy for localized @entity694 . @entity1 : 3278 @entity1 with resected @entity5 . MEASUREMENTS: Occurrence of endoscopic or radiologic colon surveillance and incidence of second primary @entity14 . RESULTS: Forty-two cases of second primary invasive @entity694 were found over 15 345 @entity1 -years of follow-up, yielding an incidence rate of 274 per 100 000 @entity1 -years (95% CI, 196 to 369 per 100 000 @entity1 -years) and a cumulative incidence of 1.5% (CI, 1.1% to 2.0%) at 5 years. This rate was compared with rates of first @entity694 in two reference groups: the general population and @entity1 who had undergone frequent colonoscopy and polypectomy because of a history of @entity6523 ; standardized incidence ratios were 1.6 (CI, 1.2 to 2.2) and 6.8 (CI, 2.7 to 22.0), respectively. CONCLUSION: The incidence of second primary @entity14 remains high despite intensive surveillance strategies.
