Endothelin expression in normal XXXX anterior pituitaries and @entity977 .

@entity1 @entity6422 @entity2013 @entity2232 @entity5 @entity10731 @entity977 @entity6423 @entity652
Endothelins (ETs) are important regulators of growth and function in many endocrine tissues. This study was designed to verify the expression of ETs in a series of normal @entity1 pituitaries and @entity977 . We examined 13 normal pituitaries and 58 @entity977 for the presence of immunoreactive (ir) @entity6422 . No ir- @entity2232 was detected in any of the 13 normal pituitaries, whereas ir- @entity6423 was observed in 4 of 13 (31%) cases. In contrast, 48% (28 of 58) of @entity977 display immunoreactivity for @entity2232 , whereas 31% (18 of 58) show immunoreactivity for @entity6423 . With respect to the type of @entity5 , staining was as follows: nonfunctioning @entity652 : @entity2232 , 14 of 33; @entity6423 , 9 of 33; somatotropinomas: @entity2232 , 8 of 16; @entity6423 , 6 of 16; corticotropinomas: @entity2232 , 5 of 5; @entity6423 , 2 of 5; and @entity2013 ; @entity2232 , 1 of 4; @entity6423 , 1 of 4. Using double immunostaining, we found the colocalization of @entity6423 in normal pituitaries and of @entity6422 in pituitaries @entity652 in each hormone-secreting cell. In @entity652 , @entity2232 was coexpressed in corticotropic cells in all 5 cases (100%). In the same @entity5 , by reverse transcriptase polymerase chain reaction, we investigated the presence of @entity6422 messenger @entity10731 and found that they are expressed, respectively, in 18 of 21 and 7 of 11 @entity5 examined. Our findings demonstrate that @entity977 frequently display @entity2232 as well as @entity6423 immunoreactivity, in contrast to normal pituitaries, in which only @entity6423 was found.(ABSTRACT TRUNCATED AT 250 WORDS)
