Endothelin and XXXX .

@entity2232 @entity26 @entity409 @entity842 @entity4493 @entity65
@entity842 (NO) and endothelin (ET) produced in endothelial cells are leading molecules which regulate vascular function. Failure of the physiological balance between these two molecules is usually referred to as @entity409 . ET was initially identified as a potent vasoconstrictive peptide. Three ET isoforms and two ET receptors have been identified. One of the isoforms, @entity2232 , plays a significant role in many @entity65 . On the other hand, oxidized low-density lipoprotein (oxLDL) is known to induce @entity409 . The endothelial receptor for oxLDL was cloned, and named @entity4493 ( @entity4493 ). Activation of @entity4493 generates reactive @entity26 species (ROS), and acivates a transcriptional factor, nuclear factor kB (NFkB), resulting in down-regulation of NO and up-regulation of @entity2232 . @entity4493 might be a key molecule in the generation of @entity409 . In @entity409 , @entity2232 is an aggravating factor of @entity65 .
