Cyclin E is overexpressed by clear cell XXXX of the endometrium and is a prognostic indicator of survival.

@entity1204 @entity1 @entity851 @entity5 @entity189 @entity4910 @entity1962
OBJECTIVE: Upregulation of cyclin E and @entity4910 -6 accelerates the transition from G1 to S phase. The objective of this study was to determine if @entity4910 and E are prognostic indicators in @entity1204 . MATERIALS AND METHODS: Surgically-treated @entity1 with @entity1204 had their @entity5 stained for nuclear expression of @entity4910 . Quantification of staining and measurement of growth phase fraction were performed using image analysis. FIGO stage, grade, and histology were also analyzed. RESULTS: @entity4910 and E expression was unrelated to DNA index (p = 0.93). While @entity4910 expression did not correlate with S+G2M phase fraction (p = 0.69), increased cyclin E expression was directly correlated with increased S+G2M phase fraction (p = 0.002). Cyclin E expression was highest in clear cell @entity189 (p = 0.042) while @entity4910 expression was highest in @entity1962 (p = 0.028). @entity1 dying from @entity5 had significantly higher expression of @entity4910 (p = 0.042) and E (p = 0.02) as compared to @entity1 surviving their disease. Multivariate logistic regression revealed FIGO stage, grade, and lack of cyclin E overexpression to be independent prognostic indicators of survival. CONCLUSION: Cyclin E expression is related to @entity851 , clear cell histology, and decreased survival in @entity1 with @entity1204 .
