Simultaneous radiochemotherapy in the treatment of inoperable, locally advanced XXXX . A single-institution study.

@entity1 @entity135 @entity137 @entity900 @entity33 @entity1487
BACKGROUND: @entity1 with advanced, inoperable @entity135 have cure rates of approximately 10-15%. In these @entity1 , concomitant chemoradiotherapy seems to improve local control and survival. @entity1487 ( @entity1487 ) administered by continuous infusion and @entity900 plus concomitant conventional radiation therapy may be promising in treating advanced, inoperable @entity135 . METHODS: Forty-five evaluable @entity1 with primary nonmetastatic, inoperable @entity135 were treated. From January 1987 to April 1988, the @entity1 were treated with @entity900 plus radiation therapy (Group 1) and from May 1988 to November 1990, they were treated with the same combination plus @entity1487 , given in continuous infusion (Group 2). Clinical and pathologic responses were assessed after radiation therapy was completed. @entity1 who relapsed underwent salvage surgery, if possible. The disease free and overall survival rates of the @entity1 were evaluated. RESULTS: The overall response rate (complete and partial response) was 93%, 60% of which comprised complete remissions. Despite the high response rates obtained in the two groups, the time to progression for complete responses and the median survival time were unsatisfactory (13 [Group 1] and 10 months [Group 2] and 17 [Group 1] and 16 months [Group 2], respectively). The @entity137 rate from the two treatments was not relevant. A Grade II @entity33 , according to the World Health Organization, was found in 25 @entity1 , and the treatment was interrupted for 7-10 days in 5. CONCLUSIONS: In this study, despite an improvement in the number of complete responses, the chemotherapeutic regimen with or without @entity1487 did not prolong the overall @entity1 survival significantly.
