Significant effect of homologous recombination DNA repair gene polymorphisms on XXXX survival.

@entity1 @entity788 @entity41492 @entity20822 @entity5 @entity377 @entity71511 @entity49727 @entity20823 @entity3 @entity204 @entity44300
Genetic variation in DNA repair may affect the clinical response to cytotoxic therapies. We investigated the effect of six single @entity377 polymorphisms of the @entity49727 , @entity44300 , @entity20822 , and @entity20823 genes on overall survival of 378 @entity1 with @entity788 who were treated at University of Texas M.D. Anderson @entity5 Center during February 1999 to October 2004 and were followed up to October 2005. Genotypes were determined using the MassCode method. Survival was determined from pathologic diagnosis to @entity204 . @entity1 who were alive at the last follow-up evaluation were censored at that time. Kaplan-Meier plot, log-rank test, and Cox regression were used to compare overall survival by genotypes. A significant effect on survival of all @entity1 was observed for @entity49727 and @entity44300 genes. The median survival time was 19.2, 14.7, and 13.2 months for the @entity49727 159 AA, AC, and CC genotypes, and 16.4, 13.3, and 10.3 months for @entity44300 157 CC, CT, and TT genotypes, respectively. A significantly reduced survival was associated with the variant alleles of @entity20822 @entity41492 and @entity20823 @entity71511 in subgroup analysis. When the four genes were analyzed in combination, an increasing number of adverse alleles were associated with a significantly decreased survival. Subgroup analyses have shown that the genotype effect on survival was present among @entity1 without @entity3 or among @entity1 who receive radiotherapy. These observations suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly affect the clinical outcome of @entity1 with @entity788 .
