Relationship between XXXX levels and features of the @entity209 .

@entity209 @entity1 @entity413 @entity443
Previous studies have demonstrated that reduced plasma levels of @entity443 ( @entity443 ) are related to alterations in several features of the @entity209 in both @entity1 and @entity1 . We investigated whether @entity443 level was a global predictor of the @entity209 in a sample of 203 @entity1 , 173 premenopausal, and 46 postmenopausal @entity1 for whom we also obtained a detailed assessment of the metabolic profile, including body composition (hydrostatic weighing), abdominal adipose tissue areas (computed tomography), plasma lipid-lipoprotein levels, and @entity413 homeostasis (oral @entity413 challenge). Low @entity443 levels were associated with increased total and abdominal adiposity in @entity1 as well as in pre- and postmenopausal @entity1 . Low @entity443 levels were also associated with an altered metabolic profile, especially in premenopausal @entity1 . Subjects were subdivided according to the presence of 0, 1 to 2, or 3 or more features of the @entity209 . Twenty-five percent of @entity1 were characterized by 3 features or more, whereas most premenopausal @entity1 (61.3%) had a healthy metabolic profile (0 features) and 6.9% were characterized by 3 or more features. Most postmenopausal @entity1 (54.3%) were characterized by 1 to 2 components of the @entity209 , and 13.0% were characterized by 3 or more components. The proportion of subjects characterized by the @entity209 (3 components or more) was lower in subjects with @entity443 values in the upper tertile compared with the lower tertile in both @entity1 and premenopausal @entity1 (17.7% v 28.4% and 1.7% v 14.0%, respectively). Logistic regression analyses indicated that an @entity443 level in the upper tertile was associated with a significant reduction in the probability of being characterized by the @entity209 (odds ratios of 0.35, P =.02 for @entity1 and.11, P =.05 for premenopausal @entity1 , with the lower tertile as a reference). The logistic regression was not significant in postmenopausal @entity1 . These results suggest that plasma @entity443 level may represent a significant predictor of the @entity209 in @entity1 and premenopausal @entity1 .
