Decline of Renal Function and Progression of XXXX Are Independently Determined in @entity740 Stages 3-5.

@entity1 @entity24022 @entity8 @entity5 @entity740 @entity4346 @entity551 @entity65 @entity1002
" NlmCategory=: Invasive and noninvasive methods for evaluating the effects of hemodynamics on progression of @entity4346 ( @entity4346 ) in @entity1 with @entity740 ( @entity740 ) have been proposed. @entity551 ( @entity551 ) has been reported to be the best among selected measures of hemodynamics for predicting @entity4346 . However, there are few studies examining the relation between longitudinal changes in @entity551 and @entity8 in @entity1 with @entity740 . METHODS: Sixty-seven @entity1 with @entity740 stages 3-5 (female/male ratio: 26/41, age: 61.5    13.1 years) were followed for 5 years. Before and at the end of the 5-year period, @entity551 was recorded by an automated tonometric system (HEM-9000 AI; Omron Healthcare, Kyoto, Japan). Second systolic aortic blood pressure ( @entity24022 ) was employed as an index of @entity551 . RESULTS: Throughout the study, systolic blood pressure (SBP) was well controlled. Renal function followed by estimated glomerular filtration rate (eGFR) gradually worsened as a whole. Ten @entity1 had renal replacement therapy, 3 @entity1 developed @entity65 and 2 @entity1 were found to have a @entity5 during the 5-year observation period. @entity24022 increased from 120    19 to 125    33 mm Hg and eGFR decreased from 38.2    18.2 to 29.5    16.3 ml/min/1.73 m(2); however, these differences did not achieve significance. The @entity1002 ( @entity1002 ) index significantly increased from 115.5    10.5 to 131.2    11.7 g/m(2) (p < 0.05). Although the changes in @entity24022 and eGFR looked like a mirror image, there was no significant correlation between the two factors. Moreover, multivariate regression analysis did not reveal a close correlation between @entity24022 and @entity740 progression. In contrast to the decline of renal function, the baseline value of @entity24022 predicted an increase in the @entity1002 index. CONCLUSION: Worsening of @entity8 is not solely dependent on hemodynamics. Other factors might be involved in a complex manner.
