Comparative study of immunomodulating activity of Indian medicinal plants, XXXX and glucan.

@entity1 @entity3486 @entity19 @entity786 @entity1091 @entity4795 @entity1210
The protective effects of Asparagus racemosus (AR) and Tinospora cordifolia (TC) against myelosuppression induced by single doses of @entity786 (CP) have been previously reported. Presented here are the results of a comparative study between AR, TC, glucan and @entity3486 against the myelosuppressive effects of single and multiple doses of @entity786 in @entity19 . @entity786 was administered as a single dose 200 mg/kg subcutaneously to one group of @entity19 , while a second group received 3 doses of 30 mg/kg intraperitoneally. Both groups received AR, TC and @entity1091 orally for 15 days before CP. Glucan was administered intravenously in 3 doses, before @entity786 in the first group and together with @entity786 in the second group. In both groups peripheral and differential WBC counts were done before and after drug treatment and serially after @entity786 injection. All four drugs produced leucocytosis with @entity4795 . When compared to control group, all 4 drugs prevented, to varying degrees, @entity1210 produced by @entity786 . We conclude, therefore, that both indigenous plants, AR and TC, are potent immunostimulants, with effects comparable to @entity1091 and glucan. They need further evaluation in @entity1 receiving cytotoxic drugs.
