Factors influencing improvement of visual field after trans-sphenoidal resection of XXXX : a retrospective cohort study.

@entity1 @entity227 @entity5494 @entity7 @entity5 @entity4611
AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of @entity4611 . METHODS: This retrospective cohort study included 201 @entity1 (366 eyes) with @entity227 induced by @entity4611 . All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best-corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, @entity227 index @entity5494 ( @entity5494 ), duration of symptoms, age, sex, and volume of @entity5 were compared. Expression of @entity7 ( @entity7 ) and Ki-67 of @entity5 tissue were detected by immunohistochemical technique. RESULTS: The mean age of @entity1 was 44.23  1.29y. Ninety-three @entity1 were female and 108 were male. The mean @entity5 volume was 14.36  6.23 cm(3). The mean duration of preoperative symptoms was 11.50  0.88mo. Mean preoperative @entity5494 was -17.50  0.82 dB. Mean Preoperative visual acuity was 0.64  0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative @entity5494 absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of @entity5 (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of @entity7 in @entity5 tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in @entity5 tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026). CONCLUSION: After @entity4611 trans-sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative @entity5494 absolute value, young age, small volume of @entity5 , and expression levels of @entity7 / Ki-67.
