XXXX in childhood. Edinburgh experience 1962-82.

@entity1 @entity3329 @entity882 @entity548 @entity134 @entity381 @entity382
This retrospective review of 136 @entity1 with idiopathic @entity882 assesses the prognostic significance of various presenting parameters and the effect of therapy. Initial haemoglobin, white cell count, actual platelet count, @entity381 , @entity382 and @entity3329 had no significant effect upon the final outcome. Cases of acute I.T.P. were associated with a higher incidence of preceding infection, a shorter history of @entity548 and a preponderance of males. The presence of greater than 20 per cent lymphocytes in the bone marrow was associated with a longer time to achieve a normal platelet count (p = 0.05). @entity134 therapy shortened the time for acute cases of I.T.P. to obtain a normal platelet count (p = 0.05), but had no effect on long-term prognosis. Chronicity occurred in 25 @entity1 (18%) and nine of these had spontaneous remissions. Immunosuppressive therapy was ineffective, but nine out of 12 @entity1 were cured by splenectomy. Mortality was 0.7 per cent (one death) and general morbidity was low.
