[Difference of microvessel structure between benign and malignant XXXX and its relationship with CT enhancement level].

@entity5474 @entity1 @entity2 @entity4607
BACKGROUND: To improve the differential diagnosis accuracy for @entity5474 ( @entity5474 ), and to study the basis and mechanisms of enhancement by comparing with the microvessel constructions (microvessel density and basement membrane of microvessels) in @entity5474 . METHODS: Dynamic contrast enhancement CT scanning were performed in 38 @entity2 , 5 @entity4607 and 10 inflammatory lesions which were less than 3 cm in diameter with Siemens Plus S or Marconi MX 8000 spiral CT scanner. The CT time-attenuation curves were interpreted. The microvessel density (MVD) and the basement membrane of microvessels of the resected specimens were observed with the ABC immuno-histochemical method in all @entity1 . RESULTS: The CT contrasted value of @entity2 [(49.05  16.08) HU] and inflammatory lesions [(49.59  21.30) HU] were significantly higher than that of @entity4607 [(8.98  4.56) HU] (t=7.48, P < 0.05; t=8.35, P < 0.05), but the enhancement of @entity2 was similar to that of inflammatory lesions (t=0.76, P > 0.05). The time-attenuation curve of inflammatory lesions tended to increase faster and reach a higher peak value than that of @entity2 , and both of them maintained a high plateau after crossing. The @entity4607 showed a slight increase and demonstrated a low plateau curve. The MVD of @entity5474 was positively related to CT enhancement (r=0.805 1). The microvessel counts of @entity2 (48.45  10.09) and inflammatory lesions (49.60  19.94) were significantly higher than that of @entity4607 (8.70  7.30) (t=11.64, P < 0.001; t=6.09, P < 0.001), but no significant difference was found between @entity2 and inflammatory lesions (t=-0.26, P=0.799). There was no any difference in continuity of basement membrane between nodules with enhanced CT less than 30 HU and higher than 30 U (Chi-square=3.13, P > 0.05). CONCLUSIONS: The microvessel counts mainly contribute to the enhancement of @entity5474 . The basement membrane is not related to nodule enhancement, but it might influence the pattern of time-attenuation curve.
