Sexually transmitted XXXX . I. The anatomic distribution and pathologic grade of neoplastic lesions associated with different viral types.

@entity1 @entity3141 @entity6205 @entity66 @entity5 @entity281 @entity6068 @entity3146
Multiple colposcopic biopsy specimens were collected from 160 @entity1 , with sampling of principal @entity6068 as well as secondary areas of either minor acetowhitening or normal epithelium. Papillomaviral @entity3141 was detected by Southern blot hybridization in 197 (90%) of the 218 principal biopsy specimens and 93 (46%) of 198 secondary biopsy specimens. Although different papillomaviruses were found at different sites in 31 @entity1 , only six of 416 specimens contained multiple types within the same sample. Specific viral types were associated with specific disease patterns. Only one of 80 type 6 or 11 @entity281 had a diagnosis greater than @entity3146 , grade 2. In contrast, 42 of 48 (90%) biopsy specimens of @entity3146 , grade 3, or invasive @entity5 contained type 16, 18, or 31. Nonetheless, 12 of 124 (10%) cases of @entity6205 and @entity3146 , grade 1, were associated with types 16, 18, and 31 @entity281 . Of 58 @entity1 with @entity66 , 46 had positive hybridizations for both @entity6068 (32 showing the same type in both samples and 14 showing different viruses). Differing patterns of papillomavirus-induced disease arise partly from the predilection of specific viral types for certain anatomic sites and partly through variations in host response. Detection of viral deoxyribonucleic acid in 46% of the secondary biopsy specimens suggests that disease expression may represent focal breakdown of host surveillance within a field of latent @entity281 .
