Clinicopathological significance of XXXX macrophage metalloelastase expression in @entity1721 .

@entity1 @entity5 @entity1721 @entity10885 @entity3
OBJECTIVE: @entity1 macrophage metalloelastase is referred to as matrix metalloproteinase ( @entity10885 ), its function in @entity5 is contradictory. The current study was undertaken to investigate the role of @entity10885 in @entity1721 (SCC). @entity1 AND METHODS: We analyzed the levels of @entity10885 mRNA expression in 67 @entity1 with primary esophageal SCC by Northern blot analysis and the tissues were subjected to in situ hybridization analysis for @entity10885 . Immunohistochemical staining was performed to detect the macrophages infiltrated in esophageal SCCs. RESULTS: @entity10885 mRNA was detected in 27 of 67 esophageal SCC samples by Northern blot analysis. In situ hybridization and immunohistochemical staining revealed that @entity10885 mRNA signals are located mainly in @entity5 cells. The frequency of lymph node @entity3 was significantly higher in the @entity10885 -positive ( @entity10885 (+)) subgroup than @entity10885 -negative ( @entity10885 (-)) subgroup (p < 0.05); furthermore, invasion was significantly deeper in the MMP- 12(+) subgroup than in the @entity10885 (-) subgroup (p < 0.01). @entity10885 mRNA was inversely correlated with prognosis (p < 0.05). However, Cox multivariate analysis revealed that upregulation of @entity10885 was not related to prognosis. CONCLUSIONS: @entity10885 gene expression was associated with the progression of esophageal SCC; however, it was not an independent prognostic factor.
