Analysis of clinicopathologic factors in malignant mixed XXXX of the uterine corpus.

@entity1 @entity101 @entity548 @entity66 @entity5 @entity41 @entity3905 @entity3
The aim of this study was to retrospectively analyze the clinical and pathologic data of a series of @entity1 presenting to our unit with uterine malignant mixed @entity5 ( @entity3905 ) to attempt to identify prognostic factors and relate them to survival. Thirty-seven @entity1 diagnosed with @entity3905 of the uterus from 1988 through 2000 were identified from the gynecological @entity5 registry. Data was abstracted and analyzed. The effect of a variety of clinical, histopathologic, and surgical variables on recurrence and survival were analyzed by univariate and multivariate analyses. @entity1 tended to be postmenopausal, overweight, @entity101 , and presented with @entity548 . Preoperatively 28 (76%) were thought to have clinical stage I-II disease. Nine (32%) were upstaged based on surgical data. Five (56%) of these @entity1 were found to have gross extrauterine disease and four (44%) were found subsequently to have microscopic extrauterine disease. Twenty (54%) @entity1 underwent lymph node dissection and positive nodes were found in seven (35%) @entity1 . Nine @entity1 underwent omentectomy and disease was found in three (33%). Peritoneal washings were positive in three of 16 @entity1 (19%). At the completion of primary surgery, 27 (75%) @entity1 had no @entity66 . Twelve (44%) of these @entity1 had recurrence of disease. Median disease-free interval prior to first recurrence was 15 months. Median overall survival was 30 months. Log-rank analysis performed on multiple variables, including stage, age, @entity66 , and depth of @entity3 showed a statistically significant association with overall survival probability. Only stage remained a significant independent variable predictive of overall survival (P = 0.034). We found that stage was an independent prognostic factor for overall survival in @entity1 with uterine @entity3905 . Age, depth of @entity3 , and @entity41 were significant prognostic factors on univariate analysis. These factors may be a guide in order to select a group of high risk @entity1 that may benefit from adjuvant therapy.
