Influence of XXXX cell DNA ploidy on the natural history of @entity5 .

@entity1 @entity2007 @entity66 @entity146 @entity5
We have examined @entity5 cell DNA content as a possible variable in the behavior of early @entity5 treated by local excision. Flow cytometry assays of @entity5 cell DNA content were carried out on specimens of archived, paraffin-embedded tissue specimens from 30 @entity1 (11 male and 19 female) whose early @entity5 were treated by curative local excision more than 60 months previously. The @entity5 invaded to the muscularis mucosae in 2 @entity1 (1 with @entity2007 and 1 with @entity66 ), into the submucosa in 15 @entity1 (7 with @entity2007 and 8 with @entity66 ), and the muscularis propria in 13 @entity1 (8 with @entity2007 and 5 with @entity66 ). A total of 16 @entity1 had @entity2007 and 14 had @entity66 . Local recurrence of @entity5 developed in 12 @entity1 . Of these 12 @entity1 , 10 (83 percent) had @entity2007 . By contrast, of the 18 @entity1 who remained free of disease, 12 (67 percent) had @entity66 . Seven of the 12 @entity1 with recurrence died. Six of these seven (86 percent) had @entity2007 . The aggressive clinical behavior of the @entity5 with aneuploid DNA content was not otherwise predictable by standard histologic features. @entity146 behavior appears to correlate closely with @entity2007 in locally treated @entity5 , as opposed to a lack of correlation in our @entity1 treated with major resection. The fact that these @entity5 are being treated by local excision may allow the prognostic impact of DNA content to reflect the natural history of @entity5 .
