Increased risk of XXXX in giant cell arteritis: a general population-based study.

@entity1 @entity64 @entity66 @entity583 @entity65
OBJECTIVE: To determine the risk of newly recorded @entity583 ( @entity583 ) and @entity64 among incident GCA cases compared with controls from the general population. We also evaluated time trends during follow-up. METHODS: We conducted a matched cohort study (1996-2010) of all @entity1 with incident GCA from the province of British Columbia, Canada. We estimated incidence rates of @entity583 and @entity64 according to @entity66 duration. We calculated hazard ratios (HRs), adjusting for potential confounders. RESULTS: Among 809 individuals with GCA (mean age 75.9 years, 75.8% female), 83 developed @entity583 and 60 developed @entity64 , with corresponding incidence rates of 38.1 and 26.4/1000 @entity1 -years, respectively. Compared with non-GCA cases, the age-, sex- and entry time-matched HRs were 2.75 (95% CI 2.16, 3.50) for @entity583 and 2.21 (95% CI 1.68, 2.91) for @entity64 . When other covariates were adjusted for, the corresponding HRs were 1.77 (95% CI 1.29, 2.43) and 2.04 (95% CI 1.43, 2.93). The age-, sex- and entry time-matched HRs for @entity583 and @entity64 were highest during the first year after GCA diagnosis [4.76 (95% CI 3.29, 6.88) and 3.20 (95% CI 2.11, 4.87), respectively]. CONCLUSION: These findings provide general population-based evidence that GCA @entity1 are at a substantially increased risk of @entity65 . Increased monitoring for this potentially fatal outcome and its modifiable risk factors is warranted for GCA @entity1 .
