[ XXXX during remodeling after @entity583 ].

@entity1 @entity5988 @entity944 @entity737 @entity1188 @entity1540 @entity583 @entity67 @entity943
BACKGROUND: The effect of mechanical on electrical remodeling or electrical instability of the heart shows that it is essential for the prevention of @entity944 to avoid or delay mechanical remodeling and neurohumoral activation after @entity583 . In other words, @entity1 after @entity583 prone to neurohumoral activation need to be treated with ACE inhibitors or perhaps AT1-receptor blockers and beta blockers to maintain electrical stability. @entity737 INDICATION: MADIT I and MUSTT study showed that @entity1 with severe @entity67 after @entity583 are at high risk of @entity944 , especially in presence of electrical instabilities indicated by @entity943 . These @entity1 certainly need an @entity737 ( @entity737 ). It is not clear so far whether or not the indication needs to be extended according to the MADIT II study. In other words, need all @entity1188 @entity1 with reduced pump function an @entity737 ? There is no doubt that many @entity1 with an ejection fraction below 30% have @entity943 and fulfil therefore the inclusion criteria for the MADIT I or MUSTT study. In MADIT I, a run of three @entity1540 force was sufficient to fulfil the inclusion criteria. CONCLUSION: Another important consequence of the temporal correlation between mechanical and electrical remodeling is that specific attention must be directed to these interrelations in @entity1 after @entity583 . @entity1 who die of @entity944 in comparison to surviving @entity1 a substantial dilatation of the left ventricular during 6 months of observation which parallel the increasing incidence of @entity1540 . The consequence for therapy would be that in @entity1 who present with @entity5988 during 6 months after @entity583 , electrical instability is present and a high risk of @entity944 exists. These @entity1 probably will benefit from an @entity737 .
