Prognostic significance of peripheral monocytic myeloid-derived suppressor cells and monocytes in XXXX newly diagnosed with diffuse large b-cell lymphoma.

@entity1 @entity1892
OBJECTIVE: The revised International Prognostic Index (R-IPI) aids in predicting the prognosis of @entity1 with @entity1892 ( @entity1892 ), but R-IPI yields no significant differences in assessing different subtypes of @entity1892 . It is necessary to identify @entity1 with a high-risk of @entity1892 and alternative therapy should be delivered as early as possible. METHODS: In total, 144 @entity1 newly diagnosed with @entity1892 including 63 @entity1892 and 30 healthy controls were enrolled. Peripheral monocytic myeloid-derived suppressor cells (M-MDSC) (CD14(+)HLA(-)DR(low/-)) were detected by flow cytometry and the percentage of monocytes (M  ) was evaluated by completed blood count (CBC). The correlation between M-MDSC% and M  % was statistically analyzed. RESULTS: Compared with healthy controls, significant increase was observed in M-MDSC% and M  % in @entity1892 @entity1 (both P<0.001). Significant difference of M-MDSC% was found between GCB- @entity1892 and non-GCB- @entity1892 @entity1 in both poor (P<0.001) and very good groups (P=0.03), whereas no statistical significance in the good group (P>0.05). The M  % in non-GCB- @entity1892 @entity1 was significantly higher than that in GCB- @entity1892 counterparts merely in the poor group (P<0.001). Positive correlation was noted between M  % and M-MDSC in all @entity1892 @entity1 rather than in healthy controls (r=0.227 P=0.229). CONCLUSION: The percentage of peripheral M   was positively correlated with M-MDSC% in @entity1 with different subtypes and risks of @entity1892 . Peripheral M  % and M-MDSC% combined with R-IPI score may be useful for predicting the prognosis of @entity1 newly-diagnosed with @entity1892 .
