The pathophysiology of XXXX .

@entity1 @entity4726 @entity10189 @entity63 @entity1066 @entity2918 @entity102 @entity490 @entity158 @entity20705 @entity360 @entity2275
Heterogeneity is the most important consideration in the pathophysiology of @entity10189 . @entity1066 present clinically with @entity360 or perforation. If they heal there is no predictable recurrence. Factors concerned with mucosal defense are relatively more important than aggressive factors such as acid and pepsin. Local @entity63 is the earliest recognizable gross lesion. The gastric mucosa is at least as vulnerable as the duodenal mucosa and probably more so. Most drug-induced @entity1066 occur in the stomach. Chronic or recurrent true peptic @entity1066 (penetrating the muscularis mucosae) usually present with @entity490 . Many duodenal @entity1066 @entity1 report that the @entity158 occurs when the stomach is empty or is relieved by food, and follows a pattern of relatively long periods of freedom from symptoms between recurrences. Approximately 50% of @entity1 experience a recurrence within a year if anti- @entity1066 medication is stopped. In most western countries recurrent duodenal @entity1066 is more common than gastric @entity1066 . @entity10189 is also more common in @entity1 . Recent evidence indicates genetic and familial factors in duodenal @entity1066 and increased acid-pepsin secretion in response to a variety of stimuli. However, it is also becoming clear that of all the abnormal functions noted, few are present in all subjects and many are clustered in subgroups. In @entity2275 , defective defense mechanisms, such as @entity20705 and @entity4726 , seem to be more important than aggressive factors. Nevertheless, antisecretory medications accelerate the healing of such @entity1066 . It remains to be seen whether @entity2918 , mucus secretion, or gastric mucosal blood flow are @entity102 .
