The neuropathology of aminergic nuclei in XXXX .

@entity1 @entity308 @entity303 @entity3072 @entity195 @entity528
@entity528 and the presence of @entity3072 ( @entity3072 ) within aminergic nuclei were examined in a series of @entity1 with @entity195 ( @entity195 ). Neuromelanin-containing neurons within the locus ceruleus and large nucleolus-containing neurons within the dorsal raphe nucleus and the central superior (raphe) nucleus were counted in 25 @entity1 with @entity195 and in 12 age-matched control subjects. Numbers of @entity3072 were quantified in the same regions. Counts were compared with clinical data, including psychiatric evaluations, available for 21 of the @entity1 with @entity195 . Within the locus ceruleus in the @entity1 with @entity195 were more severe at mid level than at caudal or rostral levels (p less than 0.01). Within the dorsal raphe nucleus, @entity528 was most severe caudally (p less than 0.05). @entity3072 , but not @entity528 , were demonstrated within the central superior nucleus. Neuronal and NFT counts did not correlate at individual levels; the relative severity of both pathological processes was consistent from level to level within nuclei but was less consistent between nuclei. @entity528 correlated inversely with age, particularly within the locus ceruleus. Duration of disease correlated inversely with counts of @entity3072 , particularly within the dorsal raphe nucleus, implying a correlation between NFT counts and rate of progression of disease as all but 3 @entity1 had severe @entity303 . Significantly, @entity1 with @entity195 complicated by major @entity308 had fewer neurons at the mid level of the locus ceruleus and at the rostral level of the central superior nucleus in comparison with nondepressed @entity1 . There was a trend suggesting greater loss of neurons at all levels of the locus ceruleus and dorsal raphe nucleus in depressed individuals.
