XXXX . A clinicopathologic analysis of 26 cases.

@entity1 @entity82 @entity7577 @entity158 @entity41163 @entity923 @entity4607
Nineteen cases of @entity4607 without @entity41163 and seven cases with @entity41163 are discussed. Twenty-five involved the hand, wrist, palm, and finger, and one case involved the foot. Nineteen @entity1 had isolated fibrofatty enlargement of nerve, while seven had @entity41163 in addition to the peripheral nerve changes. Involved nerves included the median nerve, ulnar nerve, an unidentified nerve near the elbow, and a nerve on the dorsum of the foot. Four of nine @entity1 with neurologic symptoms of @entity158 or paresthesias had physical findings compatible with @entity7577 , and two others were described as having @entity923 . Most @entity1 had been aware of a mass for several years. Microscopically, the lesion was characterized by fibrofatty enlargement of nerve with massive epineural and perineural @entity82 . In two of the cases with @entity41163 , the fibrofatty enlargement of the nerve was associated with overgrowth of bone and the surrounding subcutaneous tissues. In one case, the perineural @entity82 was associated with metaplastic bone. The histogenesis of fibrofatty overgrowth of nerve has been disputed. Mature fat cells have been described within the normal nerve sheath, and it is thought that proliferation of these cells leads to the fatty enlargement of the nerve and its coverings. The relationship of these neural changes to the development of @entity41163 remains controversial. Follow-up in 18 @entity1 (69%) reveals a benign course following biopsy, limited excision, or division of the flexor retinaculum in the wrist.
