Monocyte procoagulant activity in @entity631 associated with XXXX .

@entity1 @entity8 @entity1310 @entity75 @entity1252 @entity1988 @entity631 @entity6236 @entity454
Monocyte infiltration and activation of the coagulation system have been implicated in the pathophysiology of @entity631 . In this study, spontaneous procoagulant activity (PCA) was measured in circulating mononuclear cells to determine whether elevated PCA correlated with the presence of proliferative @entity631 in @entity1 with @entity1252 ( @entity1252 ). No increase in PCA was found in 20 @entity1 with @entity454 , 8 @entity1 with @entity631 without @entity1252 , and 10 @entity1 undergoing abdominal surgical or orthopedic procedures as compared with 20 normal controls. In eight @entity1 with @entity1252 but with no apparent @entity8 , PCA was not elevated above normal basal levels. Seven additional @entity1 with @entity1252 who had only mesangial proliferation on biopsy also had no increase in PCA. In contrast, eight @entity1 with focal or diffuse proliferative @entity1988 , and one @entity1 with @entity1310 who ultimately developed a @entity75 , had a marked increase in PCA with greater than 100 times the base-line levels. The activity was shown to originate in the monocyte fraction of the mononuclear cells and was shown to be capable of cleaving prothrombin directly. The prothrombinase activity was not @entity6236 , because it was not neutralized by anti-Factor X serum and was not inhibited by an established panel of @entity6236 inhibitors. Monocyte plasminogen activator determinations did not correlate with @entity8 activity. We conclude that monocyte procoagulant activity, a direct prothrombinase, seems to correlate with endocapillary proliferation in @entity1988 and could be a mediator of tissue injury.
