Role of the right dorsal anterior insula in the urge to XXXX .

@entity1 @entity717 @entity1775 @entity4676
UNASSIGNED: The mid-posterior part of the insula is involved in processing bodily sensations and urges and is activated during tic generation in @entity4676 . The dorsal anterior part of the insula, however, integrates sensory and emotional information with cognitive valuation and is implicated in interoception. The right dorsal anterior insula also participates in urge suppression in healthy subjects. This study examined the role of the right dorsal anterior insula in the urge to @entity1775 . Resting-state functional magnetic resonance imaging was performed in 13 adult Tourette @entity1 and 13 matched controls. The role of the right dorsal anterior insula within the urge-tic network was investigated using graph theory-based neural network analysis. The functional connectivity of the right dorsal anterior insula was also correlated with urge and tic severity. Even though the @entity1 did not exhibit any overt tics, the right dorsal anterior insula demonstrated higher connectivity, especially with the frontostriatal nodes of the urge-tic network in @entity1 compared with controls. The functional connectivity between the right dorsal anterior insula and bilateral supplementary motor area also correlated positively with urge severity in @entity1 . These results suggest that the right dorsal anterior insula is part of the urge-tic network and could influence the urge- and tic-related cortico-striato-thalamic regions even during rest in @entity4676 . It might be responsible for heightened awareness of bodily sensations generating premonitory urges in @entity4676 .    2015 International Parkinson and @entity717 Society.
