Quality of life in mild XXXX : patterns of change in self and caregiver ratings over time.

@entity1 @entity146 @entity303 @entity73 @entity195
OBJECTIVES: To determine changes over time in self and caregiver ratings of quality of life (QoL) in @entity1 with @entity303 (PwD) and to identify factors associated with changes in QoL ratings. METHODS: In this longitudinal study, 69 @entity1 with mild @entity195 and their caregivers were assessed at baseline and after 1 year. We examined the association of QoL ratings with the following variables at the two time points: awareness of disease, @entity73 , mood, functionality, @entity146 , and caregiver burden. Multivariate regression analyses were conducted to examine the contribution of co-factors. RESULTS: At baseline, PwD self-ratings of QoL were associated with caregiver ratings of PwD QoL (p = 0.001). Caregiver ratings were associated with PwD mood (p = 0.001) and self-rated QoL (p = 0.001). After 1 year, caregiver ratings of PwD QoL changed significantly (p = 0.049, d = -0.27), whereas PwD self-ratings did not (p = 0.89, d = 0.09). PwD awareness of disease changed significantly (p = 0.001) at 1 year, having declined in 25.4% and improved in 12.3% of @entity1 . PwD QoL self-ratings were associated with caregiver ratings (p = 0.001). Caregiver ratings of PwD QoL after 1 year were associated with PwD mood (p = 0.029), self-reported QoL (p = 0.001), and awareness of disease (p = 0.033). CONCLUSIONS: The association between self and caregiver ratings of PwD QoL was maintained over 1 year. The primary factors accounting for the change in caregiver ratings were PwD mood and awareness of disease. QoL and @entity73 seem to be relatively independent in mild @entity303 .
