Electrocardiographic @entity4032 and XXXX subtype in the @entity731 risk in communities study.

@entity1 @entity64 @entity6249 @entity731 @entity1031 @entity955 @entity4032 @entity385
OBJECTIVE: The aim of this study was to assess the relationship between abnormally increased P-wave terminal force in lead V1 , an electrocardiographic (ECG) marker of @entity4032 , and incident @entity385 subtypes. We hypothesized that associations would be stronger with nonlacunar @entity64 , given that we expected @entity4032 to reflect the risk of @entity1031 rather than in situ @entity6249 . METHODS: Our cohort comprised 14,542 @entity1 45 to 64 years of age prospectively enrolled in the @entity731 Risk in Communities study and free of clinically apparent @entity955 ( @entity955 ) at baseline. @entity4032 was defined as PTFV1 >4,000 V*ms. Outcomes were adjudicated @entity385 , nonlacunar (including cardioembolic) @entity385 , and @entity64 . RESULTS: During a median follow-up period of 22 years (interquartile range, 19-23 years), 904 @entity1 (6.2%) experienced a definite or probable @entity385 . A higher incidence of @entity64 occurred in those with baseline @entity4032 (incidence rate per 1,000 @entity1 -years, 6.3; 95% confidence interval [CI]: 5.4-7.4) than in those without (incidence rate per 1,000 @entity1 -years, 2.9; 95% CI: 2.7-3.1; p < 0.001). In Cox regression models adjusted for potential confounders and incident @entity955 , @entity4032 was associated with incident @entity385 (hazard ratio [HR]: 1.33; 95% CI: 1.11-1.59). This association was limited to nonlacunar @entity64 (HR, 1.49; 95% CI: 1.07-2.07) as opposed to @entity64 (HR, 0.89; 95% CI: 0.57-1.40). INTERPRETATION: We found an association between ECG-defined @entity4032 and subsequent nonlacunar @entity385 . Our findings suggest that an underlying @entity955 may cause @entity1031 in the absence of recognized @entity955 . Ann Neurol 2015;78:Ann Neurol 2015;78:679-696.
