Glomerular surface area is normalized in @entity19 born with a nephron deficit: no role for XXXX receptors.

@entity7515 @entity4295 @entity1184 @entity19 @entity1564 @entity51 @entity19729 @entity14207
We examined whether deficits in glomerular capillary surface area associated with a @entity51 could be corrected by glomerular @entity1184 . Using unbiased stereological techniques, we examined the time course and mode of glomerular @entity1184 in @entity19 lacking one allele for @entity7515 ( @entity7515 ). These @entity7515 heterozygous (Het) @entity19 are born with approximately 30% less @entity4295 than wild-type (WT) littermates. An additional group of @entity7515 Het @entity19 received the @entity14207 antagonist @entity1564 (Cand; 10 mg x kg(-1) x day(-1)) from 5 wk of age to determine the role of @entity19729 receptors in the @entity1184 . At 10 wk of age, the total volume of renal corpuscles, glomerular capillary surface area, and length of glomerular capillaries in the kidneys of @entity7515 Het @entity19 were all markedly (approximately 45%) less than that of WT @entity19 (P < 0.001). However, by 30 wk, and persisting at 60 wk of age, @entity7515 Het and WT @entity19 did not significantly differ in any of these parameters. Furthermore, conscious 24-h mean arterial pressure (MAP) did not differ between @entity7515 Het and WT @entity19 at any time point. MAP of @entity7515 Het-Cand @entity19 was 20-30 mmHg less than that of @entity7515 Het-vehicle @entity19 at all three ages, but Cand treatment did not significantly alter glomerular capillary dimensions. In conclusion, we have demonstrated that the deficit in glomerular capillary surface area associated with a @entity51 can be corrected for in adulthood by an increase in the total length of glomerular capillaries. This process does not require @entity19729 receptor activation.
