Efficacy of a paste formulation of XXXX for the treatment of naturally occurring @entity2275 in training standardbred racehorses in Canada.

@entity3529 @entity1641 @entity1819 @entity1066 @entity4546 @entity2275
The efficacy of a paste formulation of the H+, @entity3529 , -ATPase inhibitor @entity4546 was evaluated in standardbred racehorses for the treatment and prevention of @entity2275 . Twenty standardbred racehorses in training, aged 2 to 9 years, were enrolled from 2 training centres in this field trial. Endoscopic examinations confirmed the presence of @entity2275 in all @entity1641 , prior to allocation and treatment and on day 0. Lesions were scored on a scale of 0 to 3 (intact epithelium to extensive @entity1066 ). Replicates were formed, based on training level and location. Within replicates, 1 @entity1641 was assigned to group 1 and 3 @entity1641 were assigned to group 2, randomly. @entity1641 in group 1 were sham-dosed controls. @entity1641 in group 2 were given @entity4546 paste orally at 4 mg/kg bodyweight (BW)/day from day 0 to day 27 and 2 mg/kg BW/day of @entity4546 paste orally from day 28 to day 57. Follow-up endoscopies were conducted on post treatment days 28 and 58 or 59. Physical examinations, including BWs, were conducted on all @entity1641 prior to treatment and on days 13 or 14, 28, 42 or 43, and 58 or 59. @entity1641 treated with @entity4546 had significantly (P < 0.01) more improvement in @entity1819 scores than did controls at day 28 and at study termination on days 58 or 59. All of the @entity4546 -treated @entity1641 were improved relative to baseline @entity1066 score at both examinations, and 73.3% were healed (lesion score of 0) at both examinations. None of the controls improved at any point during the study. When the dose was reduced to 2 mg/kg BW, 80% of the @entity1641 showed no recurrences or worsening in @entity2275 . It was concluded that @entity4546 paste at 4 mg/kg BW orally, once daily is highly effective in healing @entity2275 in standardbred racehorses in training and that a dose of 2 mg/kg BW orally, once daily, effectively prevents the recurrence of @entity2275 in most @entity1641 .
