Intracardiac measurement of pre-ejection myocardial velocities estimates the transmural extent of viable myocardium early after reperfusion in XXXX .

@entity5045 @entity1707 @entity39 @entity63 @entity1563 @entity583
OBJECTIVES: We hypothesized that wall motion velocity during pre-ejection is proportional to the regional content of viable myocardium after reperfusion for @entity583 ( @entity583 ). BACKGROUND: Pre-ejection wall motion consists of short and fast inward and outward movement towards and away from the center of the left ventricle (LV) and is altered during regional @entity63 . This short-lived event can be accurately quantified by Doppler myocardial imaging (DMI). METHODS: Fourteen open-chest @entity1707 underwent 60 to 120 min of left anterior descending @entity1563 followed by 30 min of reperfusion. The DMI data were collected using a phased-array intracardiac catheter (LV cavity) from @entity63 and nonischemic myocardium encompassed within a plane passing through two epicardial bead markers. Peak tissue velocities during isovolumic contraction (IVC) (peak positive and peak negative), ejection (S) and early filling (E) were measured. The cardiac specimen was sliced through the epicardial markers in a plane approximating the ultrasound imaging plane. The @entity39 ( @entity39 ) (%) was measured by @entity5045 staining. RESULTS: During @entity63 , positive IVC velocity was zero in @entity63 walls with @entity39 >20%. At reperfusion, positive IVC velocity correlated better with @entity39 (r = -0.94, p < 0.0001) than it did S (r = -0.70, p < 0.01) and E (r = -0.81, p < 0.01). Differential IVC (the difference between peak positive and peak negative velocity) highly correlated with @entity39 , during @entity63 (r = -0.78, p < 0.001) and during reperfusion (r = -0.93, p < 0.0001). CONCLUSIONS: Pre-ejection tissue velocity, as measured by intracardiac ultrasound, allows rapid estimation of the transmural extent of viable myocardium after reperfusion for @entity583 .
