XXXX gene polymorphism associated with premature @entity453 and @entity9680 .

@entity1 @entity301 @entity9680 @entity9379 @entity1675 @entity453 @entity165
Decreased plasma high-density-lipoprotein (HDL) @entity165 and @entity1675 levels have been associated with premature @entity453 . We identified a @entity9379 restriction-endonuclease site flanking the @entity1 @entity1675 gene at its 3' end that is polymorphic. The absence and presence of this site, as determined by genomic blotting analysis of @entity9379 -digested chromosomal DNA with the use of an @entity1675 gene probe, were associated with 3.3-kb and 2.2-kb hybridization bands, respectively. The 3.3-kb band appeared in 4.1 percent of 123 randomly selected control subjects and in 3.3 percent of 30 subjects with no angiographic evidence of @entity453 . In contrast, among 88 @entity1 who had severe @entity301 before the age of 60, as documented by angiography, the 3.3-kb band occurred in 32 percent (P less than 0.0001). It was also found in 8 of 12 index cases (P less than 0.0001) of kindreds with @entity9680 . In the two @entity1 groups, the allele frequencies of the site that produced the 3.3-kb band were 17 and 42 percent, respectively, as compared with an allele frequency of only 2 percent in the control populations. Within kindreds with @entity9680 and among first-degree relatives of @entity1 with @entity453 , the 3.3-kb band was associated with decreased HDL @entity165 levels. Among all @entity1 with @entity453 , 58 percent had HDL @entity165 levels below the 10th percentile of normal values; however, this frequency increased to 73 percent when @entity1 with the 3.3-kb band were considered. These findings indicate that the polymorphism in the region between the @entity1675 and apolipoprotein C-III genes may be a useful marker for the risk of premature @entity453 and @entity9680 .
