Correlation of numerical chromosome 11 and 17 imbalance with XXXX of primary @entity0 to lymph nodes.

@entity0 @entity5 @entity189 @entity3 @entity2008 @entity420
Abnormalities of chromosomes 11 and 17 have been widely reported in invasive @entity0 . Interphase cytogenetics using pericentromeric repeat probes allows the evaluation of numerical chromosomal aberrations in @entity5 cell populations. We have developed a method for interphase cytogenetics on fine needle aspirates taken from @entity0 and have applied it to the analysis of chromosomes 11 and 17 in 49 cases of invasive @entity420 . Frequency distributions of signal number were generated for each case and no correlation was found between modal signal number and @entity5 size at presentation, nodal status or @entity5 differentiation. In 14 cases, two copies of each of chromosomes 11 and 17 were present, and in 14, the number of chromosomes 11 and 17 were equal but abnormal. In 14 cases, the chromosome 11 number was greater than chromosome 17 and in 7 cases, the chromosome 17 number was greater than chromosome 11. Chromosome inequality correlated with the presence of lymph node @entity3 or disseminated disease at presentation and the absence of in situ @entity189 . There was no relationship with the presence of vascular invasion. These data suggest that numerical chromosome 11 and 17 imbalance may indicate the ability of @entity0 to @entity3 rather than invade vessels. The pattern of numerical @entity2008 described may define a subgroup of @entity5 with a greater tendency for @entity3 .
