[Effect of @entity19316 on expression of Fas/ @entity12 in @entity651 induced by @entity63 /reperfusion in XXXX ].

@entity19316 @entity63 @entity95 @entity651 @entity12 @entity5053
AIM: To investigate the effect of @entity19316 ( @entity5053 ) on expression of Fas/ @entity12 mRNA during @entity63 /reperfusion injury (PI/RI) in the @entity95 . METHODS: Single @entity63 /reperfusion animal model was used in this study. The @entity95 were randomly divided into three groups (n = 30, in each): sham operated group (Sham), I/R group (I/R) and I/R + @entity5053 group (I/R + @entity5053 ). Changes of several parameters which included apoptotic index (AI), wet to dry ratio of lung tissue weight (W/D) and index of quantitative assessment of histologic @entity651 (IQA) were measured at 1h, 3h, 5h after reperfusion in lung tissue. Meanwhile the location and expression of Fas/ @entity12 mRNA were observed. Lung tissue was prepared for light microscopic and electron microscopic ob servation at 1 h, 3 h, 5 h after reperfusion. RESULTS: As compared with group I/R, Fas/ @entity12 mRNA slightly expressed in intima and extima of small pulmonary artery, alveoli, and bronchiole epithelia in group @entity5053 . The values of AI, W/D and IQA showed significantly lower in group I/R + @entity5053 than that in group I/R at 1 h, 3 h, 5 h after reperfusion in lung tissue (P < 0.01 and P < 0.05). Meanwhile, abnormal changes of the lung tissue in morphologically were lessen markedly in group I/R + @entity5053 . CONCLUSION: @entity19316 has notable protective effects on PI/RI in @entity95 by inhibiting Fas/ @entity12 mRNA express in lung tissue and decreasing apoptosis.
