Investigation of XXXX in @entity1091 -free adults with @entity162 using cortical pattern matching.

@entity1 @entity162 @entity2526 @entity716 @entity1091 @entity62
OBJECTIVE: Although several lines of evidence implicate gray @entity62 in the prefrontal cortex and anterior cingulate cortex in @entity1 with @entity162 , findings have been largely inconsistent across studies. Differences in @entity1 ' medication status or mood state or the application of traditional volumetric methods that are insensitive to subtle neuroanatomical differences may have contributed to variations in findings. The authors used MRI in conjunction with cortical pattern matching methods to assess @entity2526 in euthymic bipolar @entity1 who were not receiving @entity1091 treatment. METHOD: Thirty-four @entity1091 -free euthymic @entity1 with @entity162 and 31 healthy comparison subjects underwent MRI scanning. Data were processed to measure cortical gray matter thickness. Thickness maps were spatially normalized using cortical pattern matching and were analyzed to assess illness effects and associations with clinical variables. RESULTS: Relative to healthy comparison subjects, euthymic bipolar @entity1 had significantly thinner gray matter in the left and right prefrontal cortex (Brodmann's areas 11, 10, 8, and 44) and the left anterior cingulate cortex (Brodmann's areas 24/32). Thinning in these regions was more pronounced in @entity1 with a history of @entity716 . No areas of thicker cortex were detected in bipolar @entity1 relative to healthy comparison subjects. CONCLUSIONS: Using a technique that is highly sensitive to subtle neuroanatomical differences, significant regional cortical thinning was found in @entity1091 -free euthymic @entity1 with @entity162 .
