Multicenter evaluation of six methods for predicting XXXX maintenance-dose requirements from initial response.

@entity1 @entity1372 @entity556 @entity1229
@entity1229 maintenance-dose requirements predicted by six mathematical methods based on initial response to therapy were compared with @entity1 ' actual dose requirements in a multicenter trial. Data were collected for @entity1 who had received an initial regimen of @entity1229 10 mg orally every 24 hours for three days and for whom a @entity556 time (PT) had been determined 16-20 hours after the third dose. @entity1 ' individual dose requirements and PT values were recorded during one to three follow-up visits after discharge from one of seven medical centers. @entity556 ratios ( @entity1 PT divided by control PT) calculated on day 4 were used for maintenance-dose prediction by five methods; a sixth method was based on the cumulative @entity1229 dose-PT response curve up to a PT value of 20 seconds. For 54 @entity1 and 30 @entity1 who qualified for the study, 197 maintenance-dose-PT response measurements were recorded; 95 in the first four weeks of therapy, 76 during weeks 5-12, and 26 at 6-12 months after initial treatment. @entity556 ratios were within the therapeutic range (PT 1.5-2.5 times the control value) in 154 observations, and the mean actual @entity1229 @entity1372 maintenance dose associated with therapeutic response was 7.6 mg/day. For @entity1 with therapeutic @entity556 ratios, dose predictions by the five methods using @entity556 ratios (PRs) correlated significantly with actual dose requirements. The formula that predicted doses numerically closest to the actual dose is as follows: Dose = 11.17 - 21.08 (log PR). Only 45 observations were obtained for the sixth prediction method, and the correlation between actual and predicted doses was not significant. Initial @entity1229 maintenance-dose requirements can be predicted effectively based on one PT determination after administration of three daily 10-mg doses.(ABSTRACT TRUNCATED AT 250 WORDS)
