Prognostic value of neutrophil-to-lymphocyte ratio in XXXX .

@entity1 @entity0 @entity66 @entity5 @entity3 @entity1349
UNASSIGNED: Inflammation is an essential component of pathogenesis and progression of @entity5 . A high neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic indicator for @entity0 . This meta-analysis was conducted to establish the overall accuracy of the NLR test in the diagnosis of @entity0 . A comprehensive search of the literature was conducted by using PubMed, Web of Science and China National Knowledge Infrastructure (CNKI). Published studies dating up to July 2014 and 4,293 @entity1 were enrolled in the present study. In order to evaluate the association between NLR and @entity1349 ( @entity1349 ), @entity66 ( @entity66 ), recurrence-free survival (RFS) or @entity5 specific survival (CSS), the hazard ratios (HRs) and their 95% confidence intervals (CIs) were extracted. @entity1349 was the primary outcome. The results suggested that increased NLR was a strong predictor for @entity1349 with HR of 2.28 (95% CI  =  1.08-4.80, Pheterogeneity  <  0.001). Stratified analyses indicated that a high NLR appeared to be a negative prognostic marker in Caucasian populations (HR  =  4.53, 95% CI  =  3.11-6.60, Pheterogeneity   =  0.096), multivariate analysis method (HR  =  2.10, 95% CI  =  1.52-2.89, Pheterogeneity  =  0.591), and mixed @entity3 (HR  =  4.53, 95% CI  =  3.11-6.60, Pheterogeneity  =  0.096). Elevated NLR was associated with a high risk for @entity66 (HR  =  1.38, 95% CI  =  1.09-1.74, Pheterogeneity  =  0.050) and in subgroups of multivariate analysis (HR  =  1.64, 95% CI  =  1.25-2.14, Pheterogeneity  =  0.545) and mixed @entity3 (HR  =  1.99, 95% CI  =  1.28-3.09, Pheterogeneity  =  0.992). In summary, NLR could be considered as a predictive factor for @entity1 with @entity0 .
