Elevated resting heart rate predisposes XXXX in @entity1 rather than in @entity1 : a 15-year prospective study.

@entity209 @entity1 @entity15 @entity299
BACKGROUND: Increasing evidences have indicated that there are gender differences in the prevalence of @entity209 ( @entity15 ), but the mechanism is uncertain. METHODS: A total of 711 subjects aged 35-65  years accepted health examinations both in 1992 and 2007. Since 114 subjects had @entity15 and 7 had @entity299 at baseline, they were excluded from the analysis. Therefore, 590 subjects with complete data (male: 61.5  %) were available and analysed. After the relationship between gender and incident @entity15 at follow-up was tested, these subjects were categorized into four groups according to the baseline resting heart rate(RHR) classified by genders. Trend tests of @entity15 incidences across the four groups of resting heart rate were conducted by Cochran-Armitage tend tests in both @entity1 and @entity1 . Additionally, three logistic regression models were used to estimate the effects of RHR on the new onset of @entity15 by taking RHR as a continuous variable(per 4 beats/min elevation). RESULTS: Gender( @entity1 ) itself was an independent risk factor for incident @entity15 at follow-up(OR   =   2.64, 1.33-5.23, P   =   0.005). The incidences of @entity15 according to the RHR categories showed a statistical linear trend in @entity1 (P for trend   =   0.018) rather than in @entity1 (P for trend   =   0.194). The ORs[95  % confidence intervals(CIs)] of @entity15 for each 4  bpm elevation in RHR was 1.18(1.03-1.36)(P   =   0.020) in a univariate model, 1.20 (1.04-1.38) (P   =   0.011) adjusted for age and health related behaviors only and 1.23(1.06-1.43)(P   =   0.007) adjusted for age, health related behaviors and pre-existing components of @entity15 in the baseline in @entity1 . Otherwise, RHR did not have any significant associations with incident @entity15 in @entity1 neither in a univariate model nor in multivariate models. CONCLUSIONS: In this study, elevated RHR is correlated with the development of @entity15 in @entity1 rather than in @entity1 .
