Association of @entity23353 gene promoter region XXXX with risk of @entity64 in Han Chinese.

@entity1 @entity64 @entity75 @entity385 @entity23353 @entity23354
BACKGROUND: @entity385 is a suddenly developing temporary or often permanent @entity75 . Several candidate genes have been shown to have an impact in the pathogenesis of @entity385 . Recently, the @entity23354 polymorphism in @entity23353 ( @entity23353 ) gene has been reported to be associated with @entity385 in different racial groups, but no data is available currently in Han Chinese. Our study is to investigate the association between the @entity23353 gene polymorphism @entity23354 and the susceptibility to @entity385 in Han Chinese. METHODS: 310 controls and 342 @entity1 with classified @entity385 were performed to detect the @entity23354 alleles genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in independent case-control study. RESULTS: TG levels of subjects carrying -1131C allele were elevated compared to the subjects with -1131T allele in all @entity385 subgroups and in controls. The serum TC, LDL-C and HDL-C levels did not differ between subjects with T or C alleles in each group. The overall distribution of @entity23353 @entity23354 genotype among @entity64 @entity1 and controls was significantly different (P<0.01). Frequencies of CC homozygote and C allele were significantly higher in all @entity64 subgroups than those in control group. After adjustment for conventional risk factors, logistic regression analysis showed that C allele carrier (CC+CT) of @entity23354 was an independent risk factor for all @entity64 subgroups (P<0.05). CONCLUSIONS: @entity23353 gene @entity23354 polymorphism is independently associated with the development of @entity385 in Chinese Han population, and CC homozygote may have a promoting effect on @entity385 .
