Influence of body mass index on extent of @entity453 and @entity299 in a cohort of XXXX at risk of @entity453 .

@entity1 @entity32 @entity101 @entity28 @entity1007 @entity6 @entity299 @entity453 @entity1851
BACKGROUND AND AIM: To estimate if a meaningful relationship exists between body mass index (BMI) and the entity of @entity453 , coronary events and mortality in a cohort of consecutive @entity1 with suspected @entity453 ( @entity453 ). METHODS AND RESULTS: In this prospective study, we enrolled 1299 consecutive @entity1 (905 [69.7%] males) who had undergone coronary angiography. Our sample consisted of 477 @entity1 (36.8%) of normal weight; 567 (43.6%) overweight and 255 (19.6%) @entity28 , according to the WHO classification. Conventional cardiovascular risk factors, BMI, endothelial function and subclinical @entity32 were studied. Different angiographic @entity453 scores were used to quantify @entity453 . In overweight and @entity28 @entity1 , respect to normal weight population, there is a higher prevalence of @entity101 , @entity1007 and @entity6 , but BMI was not significantly associated with greater extent of @entity453 . At follow-up (mean: 40; range: 24-82 months) @entity28 and overweight @entity1 showed a higher incidence of coronary events compared to the normal weight population (74.9% [ @entity28 ] versus 62.7% [overweight] versus 53.2% [normal weight]; adjusted relative risk [ @entity28 versus overweight]: 1.08 [95% confidence interval: 1.02-1.23]; P<0.05; and adjusted RR [ @entity28 versus normal weight]: 1.17 [95% CI: 1.10-1.42], P<0.01). Mortality from @entity299 was not significant within the categories. The Cox regression model showed flow mediated dilation (P<0.0001), high-sensitive @entity1851 (P=0.022) and BMI (P=0.045) as independent predictors of acute coronary events. CONCLUSION: BMI is not associated with the extent of @entity453 and mortality. The higher incidence of coronary events in @entity28 subjects is only partly explained by conventional associated risk factors. Impaired endothelial function and sub-clinical @entity32 could be involved in this association but BMI itself is related to cardiovascular events suggesting that other unknown (or not considered) pathways are involved.
