Catheter-Directed Thrombolysis Along with Mechanical Thromboaspiration versus Anticoagulation Alone in the Management of Lower Limb XXXX -A Comparative Study.

@entity1 @entity1212 @entity882 @entity1150 @entity2979 @entity715
@entity1212 ( @entity1212 ) with assisted mechanical thrombolysis is now considered as the standard of medical care for @entity1150 ( @entity1150 ). The study was conducted to describe the immediate and long-term (6 months) safety and effectiveness of @entity1212 in @entity1 with lower limb @entity1150 compared with the routine anticoagulation alone. All 12 to 85 years old @entity1 with recent (0-8 weeks) @entity1150 were included. In @entity1212 group, @entity715 was aspirated mechanically and streptokinase (STK) was given along with unfractionated heparin (UFH). After 6 months, deep venous patency and @entity2979 ( @entity2979 ) was assessed by using duplex ultrasound and Villalta scale, respectively. Among 51 @entity1 with completed data, 25 @entity1 were allocated additional @entity1212 given for a mean duration of 108        32 hours and 26 @entity1 were allocated standard treatment alone. Grade III (complete) lysis was achieved in 37% @entity1 and grade II (50-90%) lysis in 63% of @entity1 . @entity1 with partial lysis underwent percutaneous transluminal angioplasty and/or venous stenting. After 6 months, iliofemoral patency was found in 20 (80%) in the @entity1212 group versus 7 (23%) in anticoagulation alone group (p   <   0.01). @entity2979 was seen in 5 (20%) in the @entity1212 group versus 19 (77%) in anticoagulation alone group (p   <   0.01). We conclude that @entity1212 and conventional manual aspiration thrombectomy are an effective treatment for lower extremity @entity1150 . STK infusion can be safely given up to 6 days. As addition of UFH can cause @entity882 , so daily monitoring of complete blood counts is needed during @entity1212 .
