Presence of the HLADR13 allele among Mexican Mestizos suggests a protective factor against relapsing-remitting XXXX ( @entity3780 ).

@entity1 @entity3780 @entity17 @entity15
BACKGROUND AND OBJECTIVE: @entity15 ( @entity15 ) is a chronic @entity17 that affects the central nervous system. Researchers have looked for an association between @entity3780 ( @entity3780 ) and human leukocyte antigen (HLA) as risk or protective factor associated to ethnicity, which may add a partial explanation to disease heterogeneity and geographical variations. We described the frequency of the HLA-DR alleles in Mexican Mestizo ( @entity3780 ) @entity1 . @entity1 AND METHODS: We included 143 @entity3780 @entity1 and 377 healthy controls, both Mexican Mestizos. Previous signing informed consent, we record demographic and clinical characteristics of the @entity1 . Genetic profile was made, and HLA frequencies in both groups were compared. RESULTS: @entity3780 @entity1 were 39.8% male and 60.2% female, mean age was 35 years. While, controls were 48%male and 52% @entity1 , mean age was 38 years. The most frequent allele found in subjects with @entity3780 was DR 15 (p=0.006, OR=2.2, 95% CI: 1.3-3.6). DR 13 allele was more frequent among healthy subjects than @entity3780 @entity1 (p=0.050) with a protective OR 2.6, (95% CI: 1.3-5.2, p=0.050). CONCLUSION: In our study we found HLA DR 13 was more frequent in healthy controls than in @entity3780 @entity1 , suggesting a protective factor among Mexican Mestizo population.
