XXXX induced by subchronic administration of preferential cyclooxygenase-1 and cyclooxygenase-2 inhibitors in @entity35 .

@entity1 @entity5230 @entity548 @entity1133 @entity1819 @entity5507 @entity344 @entity9774 @entity492 @entity1011 @entity35 @entity9213 @entity4665 @entity1589 @entity356
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to induce @entity344 including @entity548 , ulceration and perforation in @entity1 and animals. The aim of this study was to compare the effects of two oxicams, preferential @entity9774 or @entity4665 inhibitors, on both @entity356 and some biological parameters (hematological, hepatic and renal) after subchronic administration (14 and 28 days) in @entity35 . Neutrophil infiltration was also assessed. Equipotent doses of @entity9213 (3.75 and 7.5 mg/kg) and @entity5230 (5 and 10 mg/kg) were administered. Both drugs dose-dependently caused multiple @entity356 and @entity548 in @entity35 after 14 and 28 days of administration. Treatment with @entity9213 led to a higher gastric damage than with @entity5230 on day 14 although these results were not significant. The levels of @entity1589 activity (as an index of neutrophil infiltration) were not changed compared with control after drug treatment. All the hematological parameters obtained after drugs administration for 14 and 28 days were in the range of normal values, and a significant increase in platelet levels could be observed in the group treated with 5 mg/kg of @entity5230 for 14 days. @entity492 aminotransferase (AST or GOT) increased significantly after 14 days, but after 28 days the values returned to normality. @entity1011 and @entity1133 did not undergo significant changes except for the @entity5230 14-day 5 mg/kg group, in which @entity5507 increased significantly over normal values. In conclusion, our results show that @entity9213 , a preferential @entity4665 inhibitor, causes rates of @entity1819 comparable to those seen with traditional NSAIDs, without inducing important changes in biological parameters.
