Efficacy and safety of single-dose XXXX vs. multiple-dose @entity3398 in preventing @entity281 after vaginal hysterectomy.

@entity1 @entity796 @entity5938 @entity4279 @entity281 @entity293 @entity8933 @entity3398
The efficacy, safety and effect of a single, 1-g dose of @entity8933 on the return of vaginal flora were compared to those of the standard regimen of three 2-g doses of @entity3398 for prophylaxis in 99 randomized @entity1 undergoing vaginal hysterectomy. Thirty-four were studied in Dallas and 65 in Los Angeles. Surgical procedures were comparable for all the antibiotic groups, although proportionately more simple hysterectomies were performed in Dallas. The @entity1 received a @entity4279 vaginal preparation immediately before surgery; vaginal packs, when used, contained no antimicrobial agents. Primary prophylactic failure (operative site @entity281 ) occurred in 1 of 52 (1.9%) and 4 of 47 (8.5%) of the @entity8933 - and @entity3398 -treated @entity1 , respectively, for a nonsignificant difference. All five primary prophylactic failures occurred in the Los Angeles @entity1 . One @entity1 in each antibiotic group developed a @entity293 and was classified as a secondary prophylactic failure. Febrile morbidity, length of hospital stay and incidence of adverse effects did not differ by antibiotic. The enterococcus was commonly found in the postoperative vaginal flora and was of no value in predicting @entity281 . Enterobacter species and @entity796 were isolated more commonly in @entity1 who received @entity3398 . Diphtheroids, @entity5938 and Peptostreptococcus species were isolated more commonly in @entity1 treated with @entity8933 .(ABSTRACT TRUNCATED AT 250 WORDS)
