The local vascular tolerance to an intravenous infusion of a concentrated @entity1160 solution in ICU XXXX .

@entity1 @entity20553 @entity1160 @entity5634 @entity2268
BACKGROUND AND AIMS: The beneficial effects of @entity1160 is well-documented in ICU @entity1 . However, the documentation and control of enteral administration of @entity1160 is still insufficient. As an adjunct to enteral nutrition, a concentrated @entity5634 solution may be given in a central venous line, but administration via a peripheral vein would be preferable. Therefore, we systematically evaluated local vascular tolerance following a concentrated @entity5634 infusion in ICU- @entity1 . METHODS: ICU- @entity1 (n=20) were randomized to receive a 20% @entity20553 infusion of 0.5 g/kg or placebo during 4 h in a peripheral vein on 3 consecutive days. Local tolerance was evaluated clinically, by Maddox score, and ultrasonically before the infusion and on days 1, 4 and 8 after the infusion. RESULTS: In the study, 56 out of 60 (93%) planned infusions were administered and 157 out of 168 (93%) clinical evaluations were successfully performed. The ultrasonic evaluation revealed that the utilized veins had a diameter of 2.15+/-0.8 mm (range, 1.0--4.4 mm). There were no signs of @entity2268 in any single vein. CONCLUSION: Administration of a @entity1160 -containing @entity5634 concentrate (20%) by peripheral veins is safe in terms of local tolerance, if a strict protocol is adapted for this purpose is used.
