Influence of plasma lipoprotein (a) levels on coronary vasomotor response to XXXX .

@entity1 @entity3763 @entity731 @entity409 @entity3452 @entity453 @entity934
OBJECTIVES: This study was undertaken to examine the influence of plasma @entity3452 [ @entity3452 ] levels on coronary endothelial vasomotor function. BACKGROUND: Epidemiologic studies have demonstrated a direct relation between elevated plasma levels of @entity3452 and increased risk of @entity453 . Well recognized coronary risk factors are known to affect endothelium-dependent vasomotion; however, the influence of @entity3452 on coronary vasomotor function has not been determined. METHODS: We used quantitative coronary angiography to measure left anterior descending coronary artery diameter changes produced by intracoronary @entity934 and @entity3763 in 30 @entity1 with angiographically normal coronary arteries. Plasma @entity3452 levels were determined with enzyme-linked immunosorbent assay. RESULTS: Vasomotor response to @entity934 ranged from +13% to -47% in the proximal, from +23% to -53% in the middle and from +13% to -56% in the distal segment of the left anterior descending coronary artery. According to univariate linear regression analysis, @entity3452 had a significant inverse correlation with vasomotor response to @entity934 : r = 0.47, p < 0.01 in the proximal; r = -0.61, p < 0.001 in the middle; and r = -0.52, p < 0.01 in the distal segment of the left anterior descending coronary artery. By multiple stepwise regression analysis, plasma @entity3452 was the significant predictor of vasomotion in response to @entity934 in all tested segments (p < 0.01). CONCLUSIONS: Elevated @entity3452 levels were associated with impairment of endothelium-dependent vasodilation even when @entity731 were not recognizable by angiography. This finding suggests that elevated plasma levels of @entity3452 cause @entity409 and may contribute in part to later development of @entity731 , as shown in epidemiologic studies.
