Rapid fall in lung density following smoking cessation in XXXX .

@entity1 @entity55 @entity2415 @entity358 @entity4184 @entity1030
INTRODUCTION: Whether smoking-induced @entity55 subsides after smoking cessation is currently a matter of debate. We used computed tomography (CT) to evaluate the effect of smoking cessation on lung density in @entity1 with @entity1030 . MATERIAL AND METHODS: Thirty-six @entity1 quit smoking out of 254 current smokers with @entity1030 who were followed with annual CT and lung function tests (LFT) for 2?4 years as part of a randomised placebo-controlled trial of the effect of inhaled @entity4184 on CT-lung density. Lung density was expressed as the 15th percentile density (PD15) and relative area of @entity2415 below -910 HU (RA-910). From the time-trends in the @entity4184 and placebo groups the expected @entity358 at the first visit after smoking cessation were calculated by linear regression and compared to the observed densities. RESULTS: Following smoking cessation RA-910 increased by 2.6% (p = 0.003) and PD15 decreased by -4.9 HU (p = 0.0002). Furthermore, changes were larger in the @entity4184 group than the placebo group (PD15: -7.1 vs -2.8 HU. RA-910 3.7% vs 1.7%). These differences were, however, not statistically significant. The LFT parameters (FEV(1) and diffusion capacity) were not significantly influenced by smoking cessation. CONCLUSION: Inflammation partly masks the presence of @entity2415 on CT and smoking cessation results in a paradoxical fall in lung density, which resembles rapid progression of @entity2415 . This fall in density is probably due to an anti-inflammatory effect of smoking cessation.
