High-Resolution Genomic Analysis Does Not Qualify Atypical Plexus Papilloma as a Separate Entity Among XXXX .

@entity1 @entity5683 @entity7 @entity41857 @entity21821 @entity1185 @entity5 @entity406 @entity189 @entity71407 @entity71408 @entity71409 @entity15470 @entity55524
UNASSIGNED: @entity5683 are rare neoplasms that mainly affect @entity1 . They include @entity1185 , @entity1185 , and @entity189 . Detailed genetic studies are rare, and information about their molecular pathogenesis is limited. Molecular inversion probe analysis is a hybridization-based method that represents a reliable tool for the analysis of highly fragmented @entity406 -fixed paraffin-embedded tissue-derived DNA. Here, analysis of 62 cases showed frequent hyperdiploidy in @entity1185 and @entity1185 that appeared very similar in their cytogenetic profiles. In contrast, @entity189 showed mainly losses of chromosomes. Besides recurrent focal chromosomal gains common to all @entity5683 , including chromosome 14q21-q22 (harboring @entity15470 ), chromosome 7q22 ( @entity21821 ), and chromosome 9q21.12 ( @entity41857 ), Genomic Identification of Significant Targets in Cancer analysis uncovered focal alterations specific for @entity1185 and @entity1185 (e.g. 7p21.3 [ @entity71407 ]) and for @entity189 (16p13.3 [ @entity55524 ] and 6p21 [POLH, @entity71408 , @entity71409 , and @entity7 ]). Additional RNA expression profiling and gene set enrichment analysis revealed greater expression of cell cycle-related genes in @entity1185 in comparison with that in @entity1185 . These findings suggest that @entity1185 represent an immature variant of @entity1185 characterized by increased proliferative activity, whereas @entity189 seem to represent a genetically distinct @entity5 group.
