Adrenal sensitivity to adrenocorticotropin 1-24 is reduced in XXXX with @entity12010 .

@entity1 @entity1369 @entity2494 @entity1887 @entity916 @entity701 @entity12010 @entity792
@entity12010 are fairly common diseases that are classified into four constellations based on the clinical clustering of the various component diseases. In types 1, 2, and 4, primary @entity1887 due to an @entity792 is usually present, but its diagnosis is often delayed because it is difficult to detect in a subclinical phase. It is widely accepted that the classical dose of 250 microg ACTH(1-24) is supramaximal, whereas 0.06 microg has been shown to be one of the lowest ACTH doses that is able to stimulate adrenal secretion in normal young subjects. The aim of this study was to clarify the sensitivity and maximal secretory response of the adrenal gland to ACTH in a group of @entity1 with at least two @entity792 , without clinical signs and symptoms of overt or subclinical hypocortisolism. @entity701 (F), @entity1369 (A), and @entity2494 ( @entity2494 ) responses to the sequential administration of very low and supramaximal ACTH(1-24) doses [0.06 microg followed by 250 microg ACTH(1-24) i.v. at 0 and +60 min] were studied in 18 @entity1 with at least two @entity792 (AP; age, 20-40 yr; body mass index, 22-26 kg/m(2)). The results in the @entity1 were compared with the results recorded in 12 normal age-matched control subjects (CS; age, 22-34 yr; body mass index, 20-25 kg/m(2)). At baseline, ACTH levels in AP were within the normal range but higher (P < 0.05) than in CS, whereas F, A, @entity2494 , urinary-free F, and plasma @entity916 activity were similar in both groups. F, A, and @entity2494 responses to ACTH were dose dependent in both groups. However, in AP, F, A, and @entity2494 levels showed no response to the 0.06- micro g ACTH dose, which, in turn, elicited clear responses (P < 0.01) in CS. On the other hand, F, A, and @entity2494 responses to 250 microg ACTH in AP were not different from those in CS. In conclusion, @entity1 with @entity792 who displayed a normal basal adrenal function showed a loss of F, A, and @entity2494 response to the very low ACTH dose, although they were normal responders to the high ACTH dose. These data are likely to indicate that a reduced sensitivity to ACTH in all adrenal zones occurs in @entity1 with different types of @entity792 .
