Three-month and long-term outcomes and their predictors in XXXX treated with intra-arterial thrombolysis.

@entity1 @entity932 @entity2653 @entity6 @entity432
BACKGROUND AND PURPOSE: Intra-arterial thrombolysis can be used for treatment of basilar @entity432 . Predictors of outcome before initiation of treatment are of special interest. METHODS: From 1992 to 2010, we treated 106 consecutive @entity1 with basilar @entity432 with intra-arterial thrombolysis. Baseline characteristics, treatment, clinical course, and 3-month and long-term outcomes (>= 12 months) were assessed. Outcome parameters were vessel recanalization after treatment, complications, modified @entity2653 (mRS) score, and mortality after 3 months and in the long-term. RESULTS: At 3 months, clinical outcome was good (mRS score, 0-2) in 33.0% of the @entity1 and moderate (mRS score, 3) in 11.3%. Mortality was 40.6%. Partial or complete recanalization was achieved in 69.8% of the @entity1 , and symptomatic @entity932 occurred in 1 @entity1 (0.9%). Between 3-month and long-term follow-up, 22 survivors (40.8%) showed clinical improvement of at least 1 point on the mRS score, 29 (53.7%) were functionally unchanged, and 3 (5.7%) showed functional worsening (P<0.0001). Multivariate analysis identified @entity6 as a predictor of poor vessel recanalization (P=0.028). Low baseline National Institutes of Health Stroke Scale score was identified as a predictor of good or moderate clinical outcome (P<0.0001) and survival (P=0.001) at 3 months, and younger age was identified as an additional predictor of survival (P=0.012). For prediction of long-term clinical outcome, age was also an independent predictor (P=0.018). CONCLUSIONS: In our series, intra-arterial thrombolysis as treatment of basilar @entity432 was safe. National Institutes of Health Stroke Scale score at admission and age were identified as predictors of outcome, and these predictors should be considered for treatment allocation in future randomized trials.
