Pharmacokinetic considerations in the treatment of childhood XXXX .

@entity1 @entity410 @entity102 @entity2495 @entity302 @entity734
Organogenesis throughout childhood affects almost every aspect of pediatric pharmacotherapy. The @entity734 ( @entity734 ) are particularly impacted since most elimination rates are diminished for the first 6 months of infancy, but quickly attain and supersede adult values. When @entity1 enter a @entity2495 stage, large doses of @entity734 may be necessary to maintain effective serum concentrations. Medication noncompliance is frequently confused as @entity2495 , since both present with low serum drug concentrations. Amazingly, noncompliance among @entity1 with @entity102 approaches a similar incidence to that reported in the adult population. It is obviously important to include this in the differential diagnosis of the etiology of subtherapeutic serum AED concentrations. Maturational differences also affect gastrointestinal drug absorption. Intestinal transit time and absorptive surface area are both diminished in young @entity1 . Drug delivery systems suitable in adults may not deliver the total dosage in @entity1 . Differences in the composition of body compartments and protein binding can alter the volume of drug distribution and, consequently, serum concentrations. In addition to pathophysiologic changes, there is evidence to suggest differences between a mature and immature brain. These differences include quantitative and qualitative responses to neurotransmitters. Hence, it is understandable why @entity410 semiology is different in @entity1 compared with adults. This constellation of factors contributes to the challenges of caring for @entity1 with @entity302 .
