Appendectomy: a risk factor for colectomy in @entity1 with XXXX .

@entity1 @entity281 @entity2718
BACKGROUND: The appendix, considered an intestinal microbiota reservoir, may be protective against the risk of fulminant @entity2718 @entity281 . METHODS: Retrospective analysis was performed in @entity1 with @entity2718 @entity281 at St. Francis Medical Center from 2007 to 2011. Outcome of @entity281 and history of appendectomy were compared. Statistical analysis was by chi-square and multivariate logistic regression. RESULTS: In total, 507 @entity1 were hospitalized for @entity2718 . Of 388 @entity1 with intact appendix, 20 (5.2%) developed fulminant @entity281 and required colectomy, whereas of 119 @entity1 with previous appendectomy, 13 (10.9%) required colectomy. An increased severity of disease, indicated by increased rate of colectomy, occurred for the group with a history of appendectomy (P = .03). Age and sex were adjusted by multivariant regression (P = .05). CONCLUSIONS: Appendectomy may be a risk factor for increased severity of @entity2718 @entity281 . Although the mechanism is unknown, further studies are warranted.
