@entity801 for prophylaxis of XXXX : a review for the dentist.

@entity1 @entity801 @entity2167 @entity4028 @entity114 @entity3639 @entity281 @entity869 @entity393 @entity3555 @entity884
New guidelines have recommended that @entity801 in combination with @entity869 be used for prophylaxis of @entity3555 in @entity1 with prosthetic heart valves. This article reviews some of the important and practical considerations for its use by the dentist. @entity801 is an @entity4028 antibiotic most exclusively reserved for treatment of serious @entity281 caused by gram-negative bacteria in which less toxic antibacterials are ineffective. It has also been shown to be impressive in combination with @entity114 in treating high-risk @entity884 @entity1 . All strains of enterococci that are resistant to @entity114 plus @entity3639 are almost always sensitive to @entity114 plus @entity801 . There is minimal absorption into the bloodstream from the gastrointestinal tract after oral administration but rapid absorption after intramuscular injection. Peak serum concentrations appear 30 to 90 minutes after intramuscular injection. The T1/2 is 2 hours, and in normal kidneys 85% to 95% of the drug is excreted within 24 hours by glomerular filtration. @entity2167 and nephrotoxicity are the most serious toxic effects resulting from @entity801 therapy. The incidence of @entity2167 is about 2%, with affected @entity1 experiencing vestibular effects rather than @entity393 . Nephrotoxicity is usually not seen before the @entity1 has had 5 to 7 days of frequent dosing for treatment of @entity281 ; the incidence is 2% to 4%. There are no data to suggest that @entity2167 or nephrotoxicity will occur in the @entity1 given a single intramuscular injection of @entity801 for the prophylaxis of @entity3555 . A single intramuscular or intravenous injection each of @entity869 and @entity801 should provide adequate blood levels for protection in the @entity884 @entity1 for at least 4 to 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
