Simultaneous Drug and Gene Delivery from the Biodegradable XXXX Nanofibers for the Treatment of @entity96 .

@entity137 @entity3373 @entity96 @entity5 @entity1311 @entity4045 @entity4351 @entity8681 @entity3 @entity1520 @entity4653
In this study, we present anti- @entity5 drug containing nanofiber-mediated gene delivery to treat @entity96 . Electro-spun nanofibers have big potential for local delivery and sustained release of therapeutic gene and drugs. We reported a temperature-responsive nanofibers mainly compounded by branched @entity4351 (PCL) macro-monomers and anti- @entity5 drug @entity1311 . The nanofiber could be administrated into @entity96 to dramatically hinder their growth and prevent their @entity3 . As a result, @entity1311 encapsulated PCL ( @entity4045 /PCL) nanofibers with diameters of around several tens nanometers to 10 nm were successfully obtained by electro-spinning and observed in @entity4653 ( @entity4653 ). Nanoparticles composed of @entity1520 cross-linked branched @entity8681 (ssPEI) and anti- @entity5 therapeutic gene @entity3373 were complexed based on the electrostatic interaction and coated over the @entity1311 -loaded nanofiber. MicroRNA 145/ss @entity8681 nanoparticles (MSNs) immobilized on the @entity4045 /PCL nanofiber showed time-dependent sustained release of the microRNA for enhanced uptake in neighboring @entity96 cells without any noticeable @entity137 . From this study we are expecting a synergistic effect on the @entity5 cell suppression since we have combined the drug and gene delivery. This approach uses the nanofibers and nanoparticles together for the treatment of @entity5 and the detailed investigation in vitro and in vivo must be conducted for the practicality of this study. The polymer is biodegradable and the @entity137 issues must be cleared by our approach.
