Reduced iNKT cells numbers in type 1 @entity6 XXXX and their first-degree relatives.

@entity1 @entity72567 @entity404 @entity6 @entity19 @entity5168 @entity405 @entity1723 @entity72568 @entity792
@entity1723 ( @entity1723 ) is an @entity792 that is characterized by the specific destruction of insulin-producing pancreatic b cells. Invariant natural killer T (iNKT) cells have been associated with development of @entity1723 . @entity72567 ( @entity72567 ) is expressed on activated iNKT, @entity405 (+), and @entity404 (+) T cells, and it is associated with the pro-inflammatory profiles of these cells. @entity72568 gene expression in @entity5168 (+) lymphocytes from non-obese @entity6 (NOD) @entity19 is associated with @entity1723 onset. However, expression of @entity72567 on T cells from @entity1 with @entity1723 has not yet been evaluated. We compared iNKT cell ( @entity5168 (+)Va24(+)Vb11(+)) numbers and @entity72567 expression in a Mexican population with recent-onset @entity1723 and their first-degree relatives with control families. Remarkably, we found lower iNKT cell numbers in @entity1723 families, and we identified two iNKT cell populations in some of the families. One iNKT cell population expressed high iTCR levels (iNKT(hi)), whereas another expressed low levels (iNKT(lo)) and also expressed @entity72567 . These findings support a probable genetic determinant of iNKT cell numbers and a possible role for these cells in @entity1723 development. This study also suggests that @entity72567 identifies recently activated iNKT lymphocytes.
