Comparison of XXXX genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study.

@entity1 @entity148 @entity301
UNASSIGNED: Aim This study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to @entity1 . BACKGROUND: @entity301 ( @entity301 ) genetic tests are increasingly available through direct-to-consumer marketing, but their potential clinical impact on cardiovascular risk assessment is unclear. METHODS: Observational study in 10 British general practices in Central England. A total of 320 individuals, who had completed conventional cardiovascular risk assessment, were offered @entity301 genetic test, with follow-up outcome questionnaire at eight months for lifestyle change and State-Trait @entity148 . Findings A total of 119 (37%) @entity1 returned genetic test specimens, with over a third reporting family history of @entity301 in a specified relative; 79 (66.4%) were categorized above-average risk on conventional cardiovascular risk assessment, 65 of whom (82.3%) were only average risk on genetic assessment. The dietary fat questionnaire was poorly completed while study participation was not associated with increased @entity148 (mean increase in @entity148 score=2.1; 95% CI -0.1-4.3; P=0.06). CONCLUSION: As a feasibility study, over a third of individuals offered genetic testing in primary care, as part of CVD risk assessment, took up the offer. Although intervention did not appear to increase @entity148 , this needs further evaluation. To improve generalizability and effect size, future studies should actively engage individuals from wider socio-economic backgrounds who may not have already contemplated lifestyle change. The current research suggests general practitioners will face the clinical challenge of @entity1 presenting with direct-to-consumer genetic results that are inconsistent with conventional cardiovascular risk assessment.
