Evaluation of antinociceptive effect of @entity1068 extract of Hedyotis corymbosa Linn. whole plant in XXXX .

@entity32 @entity2227 @entity625 @entity19 @entity406 @entity1510 @entity490 @entity158 @entity1068 @entity1543
ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including @entity490 , @entity625 and @entity32 . This study was conducted to evaluate the antinociceptive effect of @entity1068 extract of Hedyotis corymbosa (EEHC) whole plant. MATERIALS AND METHODS: The antinociceptive activity of EEHC was evaluated in @entity19 using both chemical- and heat-induced @entity158 models such as @entity1543 -induced writhing, hot plate, tail immersion, @entity406 , and @entity2227 tests at 50, 100, and 200mg/kg doses. In order to verify the possible involvement of opioid receptors in the central antinociceptive effect of EEHC, the effects found in hot plate and tail immersion tests were antagonized with @entity1510 . RESULTS: EEHC produced a dose-dependent antinociceptive effect against the chemical- and heat-induced @entity158 in @entity19 , significantly at 100 and 200mg/kg doses. These findings suggest that the action of EEHC involves both peripheral and central antinociceptive mechanisms. The antinociceptive activity of EEHC was significantly attenuated by pretreatment with @entity1510 , indicating the influence of opioid receptors on the exertion of EEHC action centrally. CONCLUSIONS: This study reports the antinociceptive activity of Hedyotis corymbosa and possible underlying mechanism(s) that supports the traditional use of this plant in the treatment of different @entity158 .
