XXXX effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion.

@entity35 @entity1219 @entity2951
OBJECTIVE: To evaluate the effect of afferent nerve blockage by administration of @entity2951 on apoptotic changes in the contralateral testis in @entity35 undergoing ipsilateral testicular torsion. MATERIALS AND METHODS: Twenty male albino @entity35 were randomly divided into four groups. In groups 1 and 2, @entity35 underwent a sham operation and testicular torsion, respectively, after the intraperitoneal administration of 0.9% @entity1219 . Similarly, in groups 3 and 4 the @entity35 underwent a sham operation and testicular torsion, respectively, after an intraperitoneal @entity2951 injection. The testes were untwisted 24 h later and the contralateral testes harvested. Apoptosis was assessed in paraffin-embedded sections stained for nuclear DNA fragmentation. Fifteen cells were counted in each seminiferous tubule and the apoptotic cells recorded. A score was calculated for each group and the results compared using the Kruskal-Wallis analysis of variance and Mann Whitney U-tests, with P<0.05 considered to be significant. RESULTS: The mean apoptotic score of group 2 was significantly higher than that of the other groups. There was no difference between the apoptotic scores of groups 1 and 3, 1 and 4, and 3 and 4. CONCLUSION: @entity2951 effectively prevented apoptosis in the contralateral testes of @entity35 that had undergone testicular torsion.
