XXXX mixed connective tissue variant: report of three cases with unusual histological findings.

@entity4772 @entity174 @entity5 @entity4771 @entity2721 @entity158 @entity8231 @entity361
@entity361 mixed connective tissue variant (PMTMCT) is a rare @entity5 occurring in bone and soft tissue that usually behaves in a benign manner. Elaboration of biologically active substances by this @entity5 gives rise to a @entity8231 known as @entity4771 , manifesting clinically as @entity158 , generalized weakness and @entity174 . Recognition of PMTMCT and its associated syndrome is important, as resection of the @entity5 in most instances results in prompt resolution of symptoms. Previously reported cases of this @entity5 have emphasized the consistent presence of certain histological features that are considered prerequisite for making the diagnosis of PMTMCT. We describe three cases of PMTMCT, of which two first presented with progressive symptoms of @entity4772 and one remained clinically silent aside from the symptom of a palpable lump. Our cases highlight the wide-ranging histological patterns displayed by these @entity5 , and draw attention to certain microscopic findings that until now have been given little if any mention. Tentacular growth pattern and satellite nodules appear to be common findings in PMTMCTs, and can make complete surgical excision of these @entity5 challenging. The ability of this otherwise histologically benign @entity5 to permeate vascular spaces has to our knowledge never been described previously. One @entity5 lacked the characteristic calcifying matrix of PMTMCT, suggesting that in some @entity5 this defining feature may be focal if not entirely absent. PMTMCT shares features with and can resemble a variety of @entity2721 , requiring the surgical pathologist to be familiar with this entity.
