Association of the Polymorphism of XXXX with the Risk and Severity of Lumbar Disc Degeneration in Chinese Han Population.

@entity1 @entity71157 @entity5 @entity2205 @entity1797 @entity39
BACKGROUND: Tumor @entity39 factor (TNF)-related apoptosis-inducing ligand ( @entity2205 ) induces apoptosis of various normal and @entity5 cells. Apoptosis plays an important role in the development of @entity1797 ( @entity1797 ). AIMS: The aim of this study was to determine whether the @entity71157 polymorphism of the @entity2205 gene is associated with the increased risk and severity of @entity1797 in the Chinese Han population. METHODS: This study consisted of 312 @entity1 with @entity1797 and 196 healthy controls. The grade of @entity1797 was determined according to Schneiderman's classification for magnetic resonance imaging (MRI). RESULTS: The genotype frequency of the @entity71157 polymorphism was in agreement with the Hardy-Weinberg equilibrium (p=0.278). @entity1 with @entity1797 had significantly lower frequencies of CT and TT genotypes compared with normal controls (p<0.001). In addition, a lower frequency of the T allele was found in @entity1 with @entity1797 than normal controls (p<0.001). Unconditional logistic regression analysis revealed that CT and TT genotypes were both significantly associated with a reduced risk of @entity1797 compared with the CC genotype (p<0.001; odds ratio [OR] 0.327; 95% confidence interval [95% CI] 0.217-0.493 and p<0.001; OR 0.393; 95% CI 0.234-0.661, respectively). Furthermore, the T allele was significantly associated with a decreased risk of @entity1797 compared with the C allele (p<0.001; OR 0.483; 95% CI 0.369-0.633). In addition, the CT and TT genotypes, as well as the T allele, were associated with lower degenerative grades of @entity1797 compared with the CC genotype and the C allele, respectively (p=0.008 and p=0.001, respectively). CONCLUSION: The @entity71157 polymorphism of @entity2205 may be adversely associated with the risk and severity of @entity1797 in the Chinese Han population.
