Possible mechanism of preventive effects of coffee intake on the formation of XXXX .

@entity24871 @entity19 @entity5834 @entity432 @entity583 @entity19501 @entity715
BACKGROUND: Prevalence and incidence of @entity432 are influenced by life-style. Coffee consumption was shown with a lower incidence of @entity583 by Framingham Study. Yet, the mechanism is to be elucidated. METHODS: We examined the effects of coffee intake on the progression of occlusive @entity715 formation in @entity19 cremasteric arteries. After 7 days of free intake of pure water, coffee containing water (5 mg/ml), or @entity5834 containing water (0.1 mg/ml), endothelial cell function was locally damaged by @entity24871 . Circulating platelet and leukocytes were rendered fluorescently by @entity19501 . Process of occlusive @entity715 growth was continuously visualized by 3-D imaging system equipped with ultra-fast confocal microscopy, and time to @entity432 was measured in each @entity19 . RESULTS: Platelet accumulation started immediately after @entity24871 exposure in all tested groups. However, arterial occlusion time in taking coffee containing water was significantly longer than those taking pure water. (46.0    17.4 min (n = 5) vs. 12.3    2.6 min (n = 31), p < 0.05) Arterial occlusion time in @entity19 taking @entity5834 (13.8    5.9 min (n = 4)) was not different from those taking pure water. CONCLUSION: Coffee, but not @entity5834 intake, may have preventive effect on arterial occlusive @entity715 formation initiated by functional injury of arterial endothelium.
