Regional aortic distensibility and its relationship with age and XXXX : a computed tomography study.

@entity2333 @entity1 @entity472 @entity15222
UNASSIGNED: @entity2333 ( @entity2333 ) decreases with age and increased @entity2333 is independently associated with adverse cardiovascular outcomes. The association of severe @entity472 ( @entity472 ) with @entity2333 in different aortic regions has not been evaluated. Elderly subjects with severe @entity472 and a cohort of @entity1 without @entity472 of similar age were studied. Proximal aortic cross-sectional-area changes during the cardiac cycle were determined using retrospective-ECG-gating on 128-detector row computed-tomography. Using oscillometric-brachial-blood-pressure measurements, the @entity2333 at the @entity15222 ( @entity15222 ), proximal-descending-aorta (PDA) and distal-descending-aorta (DDA) was determined. Linear mixed effects modelling was used to determine the association of age and @entity472 on regional @entity2333 . 102 @entity1 were evaluated: 36 @entity472 @entity1 (70-85  years), 24 @entity472 @entity1 (>85  years) and 42 @entity1 without @entity472 (9 @entity1 <50  years, 20 @entity1 between 51-70  years and 13 @entity1 70-85  years). When comparing @entity1 70-85  years, @entity15222 distensibility was significantly lower in those with @entity472 compared to those without @entity472 (0.9      0.9 vs. 1.4      1.1, P  =  0.03) while there was no difference in the PDA (1.0      1.1 vs. 1.0      1.2, P  =  0.26) and DDA (1.1      1.2 vs. 1.2      0.8, P  =  0.97). In @entity1 without @entity472 , @entity2333 decreased with age in all aortic regions (P  <  0.001). The @entity15222 in @entity1 <50  years were the most distensible compared to other aortic regions. There is regional variation in aortic distensibility with aging. @entity1 with @entity472 demonstrated regional differences in aortic distensibility with lower distensibility demonstrated in the proximal ascending aorta compared to an age-matched cohort.
