Increased angiogenesis is associated with poor prognosis of XXXX .

@entity1 @entity2280 @entity957 @entity5
BACKGROUND: Increased angiogenesis is associated with an increased risk of malignant transformation in many organs. The occurrence, characteristics and significance of angiogenesis in @entity957 are less well known. METHODS: In this study, vessel number as well as vessel size, vessel shape and vessel antibody staining intensity were determined in 23,091 vessels in @entity2280 -stained histological specimens of 42 @entity1 by computer-assisted quantitative image analysis methods and findings were related to @entity5 morphology, clinical characteristics and @entity1 survival. RESULTS: The 2- and 5-year survival rates were 81.1 and 64.1%, respectively. High disease stage and high histological grade indicated poor prognosis. In an age-adjusted multivariate analysis of stage, grade and extent of invasion, these variables compiled a statistically significant prognostic factor (p=0.001). Tumor histopathological type was a prognostic factor in our study and keratinising @entity5 did significantly better. Large @entity5 size, but not depth of invasion, and spray type growth pattern also indicated poor survival. In an age-adjusted multivariate analysis of stage, grade and extent of invasion, these variables compiled a statistically significant prognostic factor (p=0.001), but none of these variables alone proved to be an independent prognostic factor. High vessel number and increased vessel size were also significant indicators of poor survival, as were vessel characteristics: vessel number, vessel size, vessel shape and staining intensity together. CONCLUSION: Increased angiogenesis and altered vessel characteristics were prognostic factors in determining @entity1 survival in this study. Analysis of angiogenesis provided new information on @entity5 behaviour and provided markers for survival analysis in @entity5 classified by @entity5 type and growth pattern.
