The augmented neutrophil respiratory burst in response to XXXX is reduced in @entity1575 during @entity281 .

@entity1 @entity5752 @entity82 @entity295 @entity26 @entity281 @entity1575 @entity912 @entity526 @entity25159
Several functional abnormalities in phagocytes from @entity1 with @entity1575 contribute to an increased risk of @entity281 . An increased resting respiratory burst has been observed in neutrophils from cirrhotic @entity1 . We investigated whether an @entity281 in @entity82 affects the respiratory burst capacity of neutrophils and monocytes in response to @entity526 . This study included 45 hospitalized @entity1 with @entity1575 and clinical signs of @entity281 , 39 @entity1 with @entity1575 in the absence of @entity281 and 29 healthy subjects. Respiratory burst, @entity5752 ( @entity5752 ), and immunoglobulin (Ig)G-autoantibodies against oxidized low-density lipoproteins (ab-oxLDL) were measured. The fraction of neutrophils spontaneously producing reactive @entity26 species (ROS) was elevated in @entity1575 (P   <   0  01). The neutrophil resting burst increased with @entity1 -Pugh stage (P   =   0  02) and correlated with augmented ROS release in response to opsonized @entity526 (P   <   0  05). Although @entity5752 was increased in @entity1 with @entity82 (P   <   0  01), higher @entity5752 levels correlated with a lower resting burst in neutrophils (r(s)    =   -0  395; P   <   0  01). In the presence of @entity281 , the resting burst was unaltered. However, neutrophil ROS release in response to @entity526 was reduced markedly (P   =   0  01), and it decreased as serum @entity25159 ( @entity25159 ) concentration rose (r(s)    =   -0  437; P   <   0  01), indicating the development of a @entity295 -like immune @entity912 . A positive correlation between ab-oxLDL and ROS release was observed (P   <   0  01). In conclusion, the respiratory burst increases with severity of @entity1575 but is restrained by increasing @entity5752 levels. Augmented ROS release in response to @entity526 is accompanied by elevated markers of oxidative damage and becomes exhausted in the presence of @entity281 .
