@entity3251 : late pregnancy XXXX detected by neonatal screening and maternal serological testing at delivery.

@entity1 @entity281 @entity209 @entity3251 @entity3204
The first aim of this study was to determine the prevalence of @entity3251 in newborn @entity1 treated by the public health system in Porto Alegre, a city in southern Brazil, using neonatal screening for @entity3204 -specific IgM. The second aim was to investigate whether the cases detected by this approach could have been identified by the prenatal screening for antibodies to @entity3204 that was performed in the same population. A fluorometric assay was used to analyse @entity3204 -specific IgM in filter paper specimens obtained from newborn @entity1 for routine screening for @entity209 . When the specific IgM was positive, serum samples from the @entity1 and the mother were requested for confirmatory serological testing, and the @entity1 underwent clinical examination. Among 10 000 @entity1 screened for @entity3204 -specific IgM, seven filter paper samples were positive, and @entity3251 was confirmed in six @entity1 . The prevalence of IgM specific for @entity3204 was 6/10 000 [95% CI 2/10 000, 13/10 000]. One infected @entity1 had already been identified in the maternity ward before birth, three had been identified by maternal serology at delivery, and two @entity1 with @entity3251 were identified solely through neonatal screening. Although four mothers of the @entity1 with @entity3251 received prenatal care, and three mothers had one or two serological tests for T. gondii-specific antibodies (one at first trimester, one at first and second trimesters, and the other at second and third trimesters), they were not identified during pregnancy as infected. Neonatal screening identified cases of @entity281 not detected by obtaining only one or two serum samples from pregnant @entity1 for @entity3204 serology, mainly when @entity281 was acquired and transmitted in late pregnancy. Maternal serology at delivery and neonatal screening were especially useful in the identification of @entity1 with @entity3251 when the mother did not receive regular prenatal serological testing or prenatal care.
