Treating XXXX in @entity2316 .

@entity1 @entity644 @entity1289 @entity101 @entity6 @entity2316 @entity164 @entity1011 @entity454
OBJECTIVE: Control of @entity101 in @entity1 with @entity2316 improves mortality and slows progression to @entity454 . However, blood pressure is difficult to treat; multiple drug combination therapy is required and treatment algorithms to establish this are lacking. We used a stepped-care algorithm, centered on maximum doses of an @entity1289 inhibitor or angiotensin II receptor blocker, to treat @entity101 according to American @entity6 Association recommended blood pressure target goals (<130/80 mmHg) in @entity1 with @entity2316 . RESEARCH DESIGN AND METHODS: We treated 49 consecutive @entity1 with @entity6 (13 with @entity164 1 and 36 with @entity164 2), @entity2316 , and @entity644 > or =500 mg/24 h with a stepped-care blood pressure treatment algorithm. The level of blood pressure control achieved at most recent follow-up was assessed. RESULTS: @entity1 were followed for a median of 18 months (range 9-48). Mean blood pressure achieved was 140/75 +/- 23/14 mmHg in @entity1 with @entity164 1 @entity6 and 146/76 +/- 22/14 mmHg in @entity1 with @entity164 2 @entity6 . Target blood pressure was reached in 16 (33%) @entity1 , 6 of 13 @entity1 with @entity164 1 @entity6 and 10 of 36 @entity1 with @entity164 2 @entity6 , whereas systolic blood pressure remained above the target level in the remaining @entity1 . There was no difference in baseline blood pressure, @entity644 , or serum @entity1011 level between @entity1 who were treated to target and those who were not. CONCLUSIONS: Levels of blood pressure control similar to those achieved in clinical trials in @entity2316 were obtained with a stepped-care algorithm. However, in most @entity1 , systolic blood pressure was difficult to control to target despite the use of multiple drug combination therapy.
