Gamma knife stereotactic radiosurgical thalamotomy for intractable XXXX : A systematic review of the literature.

@entity1 @entity1183 @entity1269 @entity400 @entity1282 @entity717 @entity204
UNASSIGNED: @entity400 markedly reduces quality of life and causes a significant psychological burden for @entity1 who are severely affected by this @entity717 . Pharmacologic and surgical treatments for @entity400 exist, but for @entity1 who have failed medical therapy and are not surgical candidates, stereotactic radiosurgery is the only available treatment option. Of available stereotactic radiosurgical techniques for intractable @entity400 , the authors chose to evaluate the safety and efficacy of gamma knife stereotactic radiosurgical thalamotomy. In order to qualitatively synthesize available data a systematic review was conducted by searching MEDLINE (OvidSP 1946-January Week 1 2014) and Embase (OvidSP 1974-2014 January). The search strategy was not limited by study design or language of publication. All searches were conducted on January 7, 2014. Treatment efficacy, adverse outcomes, and @entity1 deaths were reviewed and tabulated. Complications appeared months to years post procedure and most commonly consisted of mild @entity1183 and @entity1269 . Rarely, more severe complications were reported, including @entity1282 and @entity204 . Though no data from randomized controlled trials are available, our analysis of the literature indicates that unilateral gamma knife thalamotomy using doses from 130 to 150Gy appears safe and well tolerated.
