Hairy/enhancer-of-split related with YRPW motif protein 1 promotes @entity3 via XXXX expression.

@entity1 @entity5 @entity421 @entity1495 @entity21507 @entity3
BACKGROUND: Activation of the Notch pathway has been reported in various types of @entity5 . However, the role of the hairy/enhancer-of-split related with YRPW motif protein 1 ( @entity21507 ) in @entity421 is unknown. We examined the function of @entity21507 in @entity421 . METHODS: Expression of @entity21507 was studied in @entity1 @entity421 . The effects of @entity21507 in @entity421 were evaluated in vitro and in a xenograft model. Moreover, we examined the function of @entity1495 ( @entity1495 ) as a downstream effector of @entity21507 . RESULTS: @entity21507 was upregulated in @entity1 @entity421 . Knockdown of @entity21507 inhibited the invasion of @entity421 cell lines. In contrast, the forced expression of @entity21507 increased the invasion of mesenchymal stem cell. In addition, lung metastases were significantly inhibited by the knockdown of @entity21507 . We found that @entity1495 was a downstream effector of @entity21507 that promotes the invasion of @entity421 cells. Knockdown of @entity21507 decreased the expression of @entity1495 . Addition of @entity1495 rescued the invasion of @entity421 cells that had been rendered less invasive by knockdown of @entity21507 expression. CONCLUSIONS: Our findings suggested that @entity21507 augmented the @entity3 of @entity421 via upregulation of @entity1495 expression. Therefore, inhibition of @entity21507 may be a novel therapeutic strategy for preventing @entity3 .
