Clinical and serological characterization of XXXX in a Tertiary Care Hospital in Eastern India.

@entity1 @entity417 @entity706 @entity425 @entity5506 @entity8428 @entity5714 @entity158 @entity2142
BACKGROUND AND AIM: @entity5506 ( @entity5506 ) primary or secondary represents approximately 16-32% of @entity5506 cases. Most @entity1 present with mild, chronic @entity5714 with exacerbation of the condition in the cold environment. Red cell transfusions are only indicated when there is a life-threatening @entity417 causing crisis. We studied the clinical and serological characterization of @entity5506 with the aim that the information gained from this study would help in proper diagnosis and management of these @entity1 . MATERIALS AND METHODS: The prospective study included nine @entity1 who were admitted with severe @entity417 . Detailed work-up were conducted to establish the diagnosis, severity of in vivo @entity2142 and transfusion management. RESULTS: All @entity1 presented with pallor, @entity425 , @entity158 with exacerbation of symptoms in winter months. Secondary @entity5506 was observed in three @entity1 suffering from @entity706 . Red cells of all @entity1 were coated with complements (C3) more specifically @entity8428 . In one @entity1 suffering from @entity706 , the cold autoagglutinin titer was as high as 4096. Autoantibody in seven @entity1 was specific to "I" antigen and one to "i" antigen. CONCLUSIONS: We conclude that detailed clinical and serological characterization is needed to diagnose and manage @entity5506 . Whereas avoidance of cold exposure is the primary therapy, but no critical @entity1 should be denied blood transfusion due to serological complications. All transfusion services should follow the correct protocol to maximize blood safety in @entity5506 .
