@entity15179 genotype predicts surgical outcome in nonpolypoid XXXX .

@entity1 @entity1127 @entity102 @entity15179 @entity480 @entity50
BACKGROUND: Over 550,000 @entity50 surgeries are performed annually in the United States on @entity1 with @entity102 ( @entity102 ). Although the results of @entity50 surgery vary widely, no known genetic factor has been identified to predict surgical outcomes. The bitter taste receptor @entity15179 has recently been demonstrated to regulate upper airway innate defense and may affect @entity1 responses to therapy. Our goal was to determine whether @entity15179 genetics predicts outcomes in @entity102 @entity1 following @entity50 surgery. METHODS: A prospective study of @entity1 undergoing @entity50 surgery evaluating postoperative outcomes through the 22-item Sino-Nasal Outcome Test (SNOT-22). @entity1 were genotyped for @entity15179 . RESULTS: A total of 123 @entity1 with @entity102 were initially analyzed; 82 @entity1 showed @entity480 (CRSwNP) and 41 @entity1 were without @entity480 (CRSsNP). Six months after surgery, the overall SNOT-22 improvement was 25    23 points. The @entity15179 genotype was found to significantly correlate with surgical outcomes in @entity1 without @entity1127 ; homozygotes for the functional receptor had a mean improvement of 38    21, whereas heterozygotes or homozygotes for the nonfunctional receptor had a mean improvement of 12    22 (p = 0.006). This result was confirmed with a multivariate regression that incorporated further @entity1 with 1-month and 3-month scores (n = 207). CONCLUSION: In @entity1 undergoing @entity50 surgery for @entity102 , we have identified a genetic polymorphism that predicts variability in quality of life improvement following surgery at 6 months in nonpolypoid @entity102 . This is the first genetic polymorphism identified that has demonstrated to predict surgical outcome for a select group of @entity102 @entity1 .
