Feasibility and repeatability of PET with the hypoxia tracer @entity26641 in oesophageal and XXXX .

@entity26641 @entity1 @entity788 @entity5
BACKGROUND AND PURPOSE: To investigate the feasibility and to determine the repeatability of recurrent @entity26641 PET scans in @entity1 with oesophageal (EC) and @entity788 . MATERIALS AND METHODS: 32 @entity1 were scanned in total; seven @entity1 (4 EC/3 PC) were scanned 2, 3 and 4h post injection (PI) of @entity26641 and 25 @entity1 (15 EC/10 PC) were scanned twice 3.5h PI, on two separate days (median 4, range 1-9days). Maximum @entity5 to background ratio (TBRmax) and the @entity5 (HV) (TBR>1.0) were calculated. Repeatability was assessed using Bland-Altman analysis. Agreement in localization was calculated as the distance between the centres of mass in the HVs. RESULTS: For EC, the TBRmax in the @entity5 (mean  SD) was 1.87  0.46 with a coefficient of repeatability (CoR) of 0.53 (28% of mean). The HV ranged from 3.4 to 98.8ml with a CoR of 5.1ml. For PC, the TBRmax was 1.72  0.23 with a CoR of 0.27 (16% of mean). The HV ranged from 4.6 to 104.0ml with a CoR of 7.8ml. The distance between the centres of mass in the HV was 2.2  1.3mm for EC and 2.1  1.5mm for PC. CONCLUSIONS: PET scanning with @entity26641 was feasible in both EC and PC @entity1 . Amount and location of elevated @entity26641 uptake showed good repeatability, suggesting @entity26641 PET could be a promising tool for radiation therapy planning and treatment response monitoring in EC and PC @entity1 .
