Previously treated, locally recurrent XXXX : treatment with superselective intraarterial chemotherapy.

@entity1 @entity2664 @entity0 @entity5
PURPOSE: To evaluate the effectiveness of intraarterial infusion chemotherapy (IAC) with @entity2664 in @entity1 with previously treated, locally recurrent @entity0 . MATERIALS AND METHODS: Thirty-nine @entity1 (aged 31-82 years) with recurrent @entity0 underwent superselective IAC (25 mg/m2 @entity2664 every 24 hours) through the subclavian artery branches after heparin administration. The extent of @entity5 perfusion was monitored with computed tomography during the intraarterial administration of contrast medium. IAC was repeated one to nine times. @entity1 had previously undergone radiation therapy (n = 39), surgery (n = 20), or systemic chemotherapy (n = 23). RESULTS: The overall response rate was 77% (n = 30). Eight @entity1 had complete remission. Progression occurred in three @entity1 . Remission was observed in cases of lymph node involvement (n = 9). Seven @entity1 are still undergoing treatment. Side effects were usually moderate. Nine @entity1 died of systemic @entity5 spread. In 14 @entity1 , distant metastases developed during the first 18 months of treatment. CONCLUSION: IAC is an effective, well-tolerated therapy in @entity1 with locally recurrent @entity0 .
