XXXX therapy of serious infections. Pharmacological aspects and side effects.

@entity1 @entity8 @entity2890 @entity1483 @entity393 @entity346
Plasma concentrations and side effects were followed in 52 adults treated with @entity2890 for 4-39 days (mean 12.2 days). In order to obtain 1-h peak levels above the recommended 4 microgram/ml in @entity1 with normal renal function, loading doses of 160 mg followed by 100-120 mg every 8 h were usually necessary. Both the leading dose and the mean daily dose of 304 mg were higher than usually recommended. Great individual variations in doses required were found and nomograms were of little value. Reduced maintenance doses were given to @entity1 with @entity8 . Adequate treatment required plasma level determinations 2-3 times a week. The high dose of @entity2890 regimen used in this study implied that 30% of the trough levels exceeded 2 microgram/ml. The frequency of clinically significant side effects were, however, low and the treatment was only interrupted once because of a decrease in renal function. @entity346 in renal function probably related to @entity2890 was found in 6 @entity1 , and 5 @entity1 got temporary disturbances of vestibular function. One @entity1 experienced a @entity393 and 2 @entity1 a permanent @entity393 , which might have been caused by simultaneous treatment with @entity1483 and @entity2890 .
