Expression of metalloproteinases and their inhibitors in XXXX .

@entity1 @entity1552 @entity5379 @entity1476 @entity5 @entity1549 @entity2843 @entity1799 @entity1082 @entity3 @entity1495 @entity420
Metalloproteinases (MMPs), a family of enzymes that participate in extracellular matrix degradation and remodeling, may play a role in @entity5 invasion and @entity3 and have been correlated with @entity5 behavior and survival. The action of MMPs is regulated by tissue inhibitors of MMPs (TIMPs). @entity420 of the uterine cervix are @entity5 that primarily affect young @entity1 and are associated with @entity1082 ). Eighteen cervical @entity420 and 5 controls were immunohistochemically analyzed for the expression of @entity1476 , @entity1549 , @entity1495 , and their inhibitors, @entity2843 and @entity1552 , in @entity5 cells and peritumoral stromal cells. These cells were also studied for the presence of @entity1476 , @entity1495 , and @entity1552 mRNA by in situ hybridization (ISH). HPV status was studied using ISH for @entity1799 and 18. @entity5379 were expressed immunohistochemically in @entity5 cells in 17 of 18 @entity5 , @entity1549 in 5, @entity2843 in 3, and @entity1552 in 1. Stromal cells of most @entity5 expressed all the above proteins. The normal endocervical epithelium was uniformly negative for @entity1476 , @entity1549 , @entity1495 , and @entity1552 , and variably expressed @entity2843 . Intense signals for @entity1476 , @entity1495 , and @entity1552 mRNA were less frequently detected by ISH in @entity5 cells and peritumoral stromal cells and were absent in normal endocervical epithelium. All @entity5 contained HPV DNA 16, 18, or both. MMP and @entity2843 expression did not correlate with @entity5 type, grade, or HPV type. MMPs and their inhibitors are present in most cervical @entity420 , independent of @entity5 grade or subtype, but with the exception of @entity2843 , they are not expressed in nonneoplastic endocervical epithelium. This finding might be helpful in the diagnosis of endocervical @entity420 . HPV is prevalent in cervical @entity420 , but its role in determining @entity5 behavior remains unclear.
