Positive impact of radiation dose on disease free survival and locoregional control in postoperative radiotherapy for XXXX of @entity418 .

@entity1 @entity957 @entity86 @entity418 @entity1349
The effect of total radiation dose (TRD) on the outcome of @entity1 with postoperative radiotherapy (RT) for @entity957 of @entity418 was assessed. Sixty-seven @entity1 with esophagectomy, followed by @entity86 for @entity957 of @entity418 from June 1984 through February 2001, were retrospectively reviewed. Of these, 13 @entity1 were excluded. No @entity1 had chemotherapy. @entity1 were classified into two groups based on TRD delivered: TRD of less than 50 Gy (Group A, n = 16) and at least 50 Gy (Group B, n = 38). Follow-up duration of all @entity1 ranged from 4 to 140 months (median, 14). Median TRD of Group A and B were 45 Gy (range, 45-48.6) and 54 Gy (range, 50-59.6), respectively. Median @entity1349 ( @entity1349 ) and disease-free survival (DFS) of all @entity1 were 15 and 10 months, respectively. Although the TRD of 50 Gy or higher was marginally significant for improved @entity1349 (hazard ration [HR] 0.559, P = 0.066), it was statistically significant for improved DFS (HR 0.398, P = 0.011), and locoregional recurrence-free survival (HR 0.165, P = 0.001) with multivariate analysis. Three @entity1 in group A and two in group B experienced a complication of grade 3 or higher. Our study suggests a positive impact of TRD of 50 Gy or higher on DFS and locoregional control, with acceptable morbidity in @entity86 for @entity1 with @entity957 of @entity418 . According to the present analysis, TRD should be at least 50 Gy in @entity86 alone setting.
