Prospective randomized comparison of XXXX - or @entity2239 -eluting stent to treat @entity75 by provisional approach.

@entity1 @entity301 @entity75 @entity3446 @entity2239
OBJECTIVES: This study sought to compare the procedural performance and the acute angiographic result on side-branch ostium obtained using 2 different drug-eluting stents (DES) to treat @entity1 with bifurcated @entity301 . BACKGROUND: Drug-eluting stents are routinely used in percutaneous coronary interventions (PCI) of bifurcated @entity301 . Different DES types have major technical differences that may influence the procedural and clinical performance in bifurcation PCI. METHODS: Consecutive @entity1 with @entity75 undergoing DES implantation using a systematic provisional-stenting strategy were randomized to @entity3446 -eluting stent (SES) or @entity2239 -eluting stent (EES) before intervention. The procedural details for PCI were prospectively recorded to assess the occurrence of any trouble in the side-branch (SB) management (primary end point). Post-PCI angiographic result (primary end point: minimal lumen diameter at SB ostium) was evaluated offline by 3-dimensional reconstruction and quantitative coronary analysis. Clinical outcome was prospectively recorded up to 18 months to assess the occurrence of target bifurcation failure. RESULTS: A total of 150 @entity1 were enrolled in the study (29% diabetics, 17% unprotected left main). The stent was successfully implanted according to randomization in all cases. Procedural performance was not significantly different between the 2 kinds of DES. Three-dimensional reconstruction and quantitative coronary analysis showed similar post-PCI results in the main vessel and better results in the SB with EES than with SES (minimal lumen diameter at SB ostium: 1.94    0.72 mm vs. 1.64    0.62 mm; p = 0.013). At 18 months, target bifurcation failure occurred in 7 (9.0%) of SES-treated @entity1 versus 8 (10.7%) of EES @entity1 (p = 0.57). CONCLUSIONS: In @entity1 with @entity75 treated by provisional stenting technique, EES compared with SES is associated with similar procedural performance and better 3-dimensional reconstruction and quantitative coronary analysis result in the SB. Both DES are associated with low rates of major adverse events and angiographic failure. ( @entity3446 Versus @entity2239 -Eluting Stent Randomized Assessment in Bifurcated Lesions and Clinical Significance of Residual Side-Branch Stenosis [SEA-SIDE]; NCT00697372).
