Association Study of the XXXX VNTR (DAT) and @entity1633 / @entity39287 Taq1A Polymorphisms with Alcohol Dependence in a Population from Northeastern Brazil.

@entity146 @entity7712 @entity988 @entity39287 @entity1633
BACKGROUND: @entity988 ( @entity988 ) is a complex @entity146 , affecting 5.4% of the general population lifetime, characterized by excessive alcohol consumption influenced by environmental risk factors and genetic factors. Genetic alterations in dopaminergic system are involved in the treatment and etiology of @entity988 . The aim of this search was to test the association of the @entity7712 40  bp-VNTR and @entity1633 / @entity39287 Taq1A single nucleotide polymorphism (SNP), a transporter and receptor of the dopaminergic system, with @entity988 through a study in a population of northeastern Brazil. METHODS: The study design was a case-control that included 227 males of northeastern Brazil (113 alcoholics and 114 controls). Alcoholics were classified according to the DSM-IV criteria for @entity988 and controls were subjects who had nonalcohol problems or who never drank. Genotyping was detected through polymerase chain reaction (PCR) for @entity7712 40  bp-VNTR and RFLP-PCR for @entity1633 / @entity39287 Taq1A, and subsequent electrophoresis on a 2% agarose gel. The distribution of allele and genotype frequencies and association of polymorphisms with @entity988 were assessed by chi-square, Fisher's exact test, and odds ratio (OR) with a confidence interval of 95% and significance p  <  0.05. Data were analyzed on BioEstat 5.3 software. RESULTS: The @entity7712 40  bp-VNTR was associated with @entity988 , allelic, and genotypic frequencies were significantly different, respectively (A9 vs. A10: OR  =  1.88; p  =  0.01; A9/A9 vs. A10/A10: OR  =  6.25; p  =  0.02; A9/A9 vs. A9/A10  +  A10A10: OR  =  5.44; p  =  0.03). However, there was no statistically significant difference when the allelic (p  =  0.10) and genotypic (p  >  0.05) frequencies for @entity1633 / @entity39287 Taq1A were compared. CONCLUSIONS: These findings suggest that A9 allele and A9/A9 genotype of the @entity7712 40  bp-VNTR are involved in the vulnerability to @entity988 in the population studied. However, for the @entity1633 / @entity39287 SNP does not present contributions to the development of @entity988 .
