Immunoradiometric assay of thyrotropin in plasma: its value in predicting response to thyroliberin stimulation and assessing thyroid function in XXXX -treated @entity1 .

@entity1 @entity1375 @entity2643 @entity1955 @entity1378 @entity1218 @entity37738 @entity1954 @entity1374
We measured thyrotropin in plasma by an ultrasensitive immunoradiometric assay (TSH-IRMA, "Sucrosep," Boots-Celltech), before and after @entity37738 ( @entity1218 ) stimulation, in 71 @entity1 with suspected @entity1374 . Thirty-three were taking @entity2643 ; none was receiving (anti)thyroid drugs. The @entity1 were divided into four groups, according to their TSH response to @entity1218 (as measured previously by conventional TSH-RIA) and the concentrations of @entity1955 (T4) and @entity1954 (T3) in their plasma. Observed ranges of plasma TSH-IRMA (milli-int. units/L) before and after @entity1218 were: euthyroid (n = 20), 0.2-3.0 and 1.7-15.5; subclinically @entity1375 (n = 14), 4.3-18.5 and 20-75; @entity1378 (n = 17), less than 0.09 and less than 0.09-0.4; and subclinically @entity1378 (n = 20), less than 0.09-1.1 and less than 0.09-2.6. Evidently TSH-IRMA results for a single sample completely distinguish @entity1378 from euthyroidism. However, TSH-IRMA values may also be undetectable in subclinical @entity1378 . The TSH response to @entity1218 can be predicted from basal TSH-IRMA results less than 0.09 or greater than or equal to 0.8 milli-int. unit/L, intermediate values can be associated with either a normal TSH response (euthyroidism) or a decreased TSH response (subclinical @entity1378 only). We advocate TSH-IRMA as the first diagnostic test of thyroid function for @entity2643 -treated @entity1 .
