Imbalanced circulating matrix metalloproteinases in XXXX .

@entity1 @entity1552 @entity3610 @entity251 @entity1476 @entity2843 @entity342 @entity1495 @entity5952
Altered levels of matrix metalloproteinases (MMPs) may reflect relevant pathogenetic mechanisms of disease conditions. The objective of this study was to compare the plasma levels of MMPs and tissue inhibitors of MMPs (TIMPs) in @entity3610 ( @entity3610 ) @entity1 with those found in healthy ovulatory controls and to examine whether the levels of these biomarkers are associated with clinical and biochemical features of this syndrome. Sixty-five healthy ovulatory subjects (controls) and 80 @entity1 with @entity3610 were include in this study. @entity1476 , @entity5952 , @entity1495 , @entity2843 , @entity1552 concentrations were measured in plasma samples by gelatin zymography or enzyme-linked immunoassays. @entity1476 , @entity5952 , @entity1495 , and @entity2843 levels were similar in @entity3610 @entity1 and in healthy controls (P > 0.05). @entity3610 @entity1 had lower plasma @entity1552 levels than healthy controls (P < 0.05). We found higher @entity1476 / @entity1552 and @entity1495 / @entity2843 ratios in @entity3610 @entity1 than in healthy controls (all P < 0.05). @entity251 levels correlated positively with the @entity1495 / @entity2843 ratio and negatively with @entity1552 levels (r = 0.26, P < 0.01 and r = -0.21, P = 0.02, respectively). In addition, only @entity251 was an independent predictor of @entity1552 levels (estimate = -0.35, P = 0.04) and the @entity1495 / @entity2843 ratio (estimate = 0.01, P = 0.04). We found evidence indicating that the balance between MMPs and TIMPs in @entity1 with @entity3610 is altered, probably due to @entity342 excess found in these @entity1 .
