Splenectomy in chronic hepatic disorders: portal vein XXXX and improvement of liver function.

@entity1 @entity648 @entity409 @entity6118 @entity157 @entity715
BACKGROUND: Splenectomy is gaining increasing importance for cirrhotic @entity1 with @entity6118 . However, its safety and efficacy for @entity1 with chronic @entity409 remain unclear. METHODS: We retrospectively examined the medical records of 38 consecutive cirrhotic @entity1 who underwent splenectomy or simultaneous hepatectomy and @entity157 . RESULTS: White blood cell and platelet counts significantly increased 3 months after splenectomy. Serum levels of total @entity648 and prothrombin time significantly improved 1 year after splenectomy. Interferon therapy was administered to 25 @entity1 after splenectomy. A sustained viral response was achieved in 8 @entity1 (42%). The total incidence of @entity715 ( @entity715 ) detected by postoperative dynamic computed tomography was 13/38 (34.2%). Multivariate analysis revealed preoperative spleen volume (SV) to be the sole independent predictor of postoperative @entity715 . Receiver-operator characteristic curve analysis showed that a cut-off SV of 450 ml corresponded to a sensitivity of 85% and a specificity of 56%. CONCLUSIONS: Splenectomy improved the liver function and facilitated effective interferon therapy in cirrhotic @entity1 with @entity6118 , although preoperative SV was frequently associated with postoperative @entity715 .
