Salivary acidic @entity1521 -rich proteins in XXXX .

@entity1 @entity18463 @entity1792 @entity2133 @entity57858 @entity1219 @entity735 @entity3669 @entity18465 @entity5828 @entity54255 @entity1521 @entity309 @entity44095
In an ongoing attempt to investigate qualitative salivary parameters in diseases affecting salivary glands, @entity1 with @entity309 ( @entity309 ) were examined. @entity1 were selected from the Oslo @entity309 register for the present study if they fulfilled the following criteria: age 52-74 years, disease duration 10-20 years, and disability score as assessed by the Modified Health Assessment Questionnaire < or = 2.5. From these 105 @entity1 , two subgroups of @entity1 were selected, one group with pronounced sicca symptoms from @entity735 , and one group without such symptoms. Sicca symptoms were assessed using a postal questionnaire with the questions on @entity2133 and dry eyes of the European classification criteria for Sj  gren's syndrome. @entity1 were excluded from further examinations if they used medication that could cause @entity2133 . Thus, nine @entity1 remained in the sicca group (having four or more sicca symptoms), and ten matched @entity309 @entity1 were selected for the nonsicca group. A healthy sex- and age-matched control group (n = 10) was also examined. In a preliminary report we have shown that differences in flow rates between sicca and nonsicca @entity309 @entity1 were limited to lower values of unstimulated whole saliva. To further evaluate salivary changes in @entity309 , a disease frequently associated with secondary Sj  gren's syndrome, we have studied qualitative salivary parameters in these @entity1 ,' including secretory rates of @entity1521 -rich proteins (PRPs), statherins, and @entity57858 . In the present report, phenotypes of PRPs, the ratio of PRPs derived from the two loci ( @entity18463 and @entity44095 ), and @entity3669 concentration and output in parotid and @entity54255 derived from the two loci are presented. Parotid (PS) and @entity54255 ( @entity54255 ) were collected from all individuals using 2% @entity1792 as a saliva stimulus. PRPs in PS and @entity54255 were identified using a SMART microchromatographic system with a Mono Q column and a Tris- @entity5828 / @entity1219 gradient (method adapted from ref. 5). For PRPs, the primary polypeptide products are coded for on two loci ( @entity18463 and @entity44095 ), which have three and two commonly occurring gene variants, respectively. On @entity18463 , the proteins @entity18463 , @entity18463 , and Pa are coded for, whereas @entity3669 -1 and @entity18465 are coded for on the @entity44095 locus. As each protein variant has a postranscriptional cleavage product, individuals will exhibit four, six, or eight PRPs in their saliva, depending on whether they are homozygous at both, one, or neither of the two loci. Accordingly, 18 possible phenotypes may exist, but as few as three phenotypes were found in 79% of the 127 healthy individuals examined by Hay et al. The SMART system allows the determination of the different acidic PRPs present in saliva. Concentrations of the various phenotypes were calculated by peak integration versus pure @entity3669 standards. Total @entity3669 concentration derived from each locus was calculated as the sum of the concentrations of @entity3669 variants from that locus.
