Studies of the reactivity of XXXX , 2-mercaptobenzothiazole and 2 of their derivatives with selected @entity1522 .

@entity1522 @entity71041 @entity535 @entity2569 @entity840 @entity4022 @entity56363 @entity2733 @entity1520 @entity3338 @entity8758
Previous studies in @entity840 showed that DTDM, @entity71041 and @entity8758 were sensitizing agents. The purpose of this study was to investigate the biochemical basis of this sensitization reaction. The reactions of representative @entity1522 , @entity2569 , Lys _ @entity4022 , with @entity56363 , DTDM, @entity71041 _ @entity8758 were examined. New compounds were found between @entity71041 and all 3 @entity1522 . Additional new compounds were seen for @entity2569 / @entity8758 , @entity2569 /DTDM, Lys/ @entity8758 _ Gly/DTDM. No reaction was observed with @entity56363 . The new compounds were examined spectroscopically. Results suggest that the sensitizing nature of DTDM is probably a reaction of its @entity1520 bond with the -SH _ - @entity2733 groups of @entity535 moieties. The conjugation of @entity2569 / @entity71041 may be via the same reaction mechanism. The -SH group of @entity8758 may react either via oxidation and/or thioester formation with the @entity3338 group of @entity1522 . These results also suggest that in vitro tests may predict the sensitizing potential of certain compounds.
