Decreased microRNA-143 expression and its @entity5 suppressive function in @entity1 XXXX .

@entity5 @entity1 @entity957 @entity6957
UNASSIGNED: MicroRNA-143 serves as a @entity5 suppressor in many @entity1 @entity5 . However, its involvement in @entity957 ( @entity957 ) is still unclear. In this study, we investigated the effects of @entity6957 in @entity957 tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected @entity6957 expression in 109 pairs of @entity1 @entity957 and adjacent noncancerous tissues. The associations between @entity6957 expression and clinicopathological factors and prognosis of @entity957 @entity1 were also statistically analyzed. Further, the effects of @entity6957 on the biological behavior of @entity957 cells were investigated. @entity6957 expression was significantly downregulated in @entity957 tissue samples and cell lines. Decreased @entity6957 expression was significantly associated with advanced T classifications, positive N classification, advanced TNM stage, and shorter overall survival. In addition, upregulation of @entity6957 in Tca8113 cells reduced cell proliferation, invasion, and migration, as well as promoted cell apoptosis in vitro. These findings validate the clinical significance of @entity6957 in @entity957 and reveal that it may be an intrinsic regulator of @entity5 progression and a potential prognostic factor for this disease.
