@entity71949 antibody treatment improves implant fixation in a model of severe XXXX .

@entity308 @entity170 @entity71949 @entity35 @entity702
BACKGROUND: The mechanical fixation of orthopaedic and dental implants is compromised by diminished bone volume, such as with @entity170 . Systemic administration of @entity71949 antibody (Scl-Ab) has been shown to enhance implant fixation in normal animals. In the present study, we tested whether Scl-Ab can improve implant fixation in established @entity170 in a @entity35 model. METHODS: We used an ovariectomized (ovx) @entity35 model, in which we found a 78% decrease in trabecular bone volume at the time of implant surgery; sham-ovx, age-matched @entity35 were used as controls. After placement of a @entity702 implant in the medullary cavity of the distal aspect of the femur, the @entity35 were maintained for four, eight, or twelve weeks and treated biweekly with Scl-Ab or with the delivery vehicle alone. Outcomes were measured with use of microcomputed tomography, mechanical testing, and static and dynamic histomorphometry. RESULTS: Scl-Ab treatment doubled implant fixation strength in both the sham-ovx and ovx groups, although the enhancement was delayed in the ovx group. Scl-Ab treatment also enhanced bone-implant contact; increased peri-implant trabecular thickness and volume; and increased cortical thickness. These structural changes were associated with an approximately five to sevenfold increase in the bone-formation rate and a >50% @entity308 in the eroded surface following Scl-Ab treatment. Trabecular bone thickness and bone-implant contact accounted for two-thirds of the variance in fixation strength. CONCLUSIONS: In this model of severe @entity170 , Scl-Ab treatment enhanced implant fixation by stimulating bone formation and suppressing bone resorption, leading to enhanced bone-implant contact and improved trabecular bone volume and architecture. CLINICAL RELEVANCE: Systemic administration of anti- @entity71949 antibodies might be a useful strategy in total joint replacement when bone mass is deficient.
