Subclinical elevation of high-sensitive troponin T levels at the convalescent stage is associated with increased 5-year mortality after XXXX .

@entity16894 @entity583 @entity1 @entity301
BACKGROUND: It is unclear whether serum high-sensitive troponin T (hs- @entity16894 ) levels at the convalescent stage of @entity583 ( @entity583 ) are associated with long-term mortality. METHODS: This study enrolled a total of 2944 consecutive @entity583 @entity1 who were registered in the Osaka Acute @entity301 Study between 2000 and 2009, and whose hs- @entity16894 levels were evaluated at the convalescent stage. @entity1 were divided into four hs- @entity16894 category groups according to the results of survival classification and regression tree (CART) analysis. The impact of hs- @entity16894 levels on 5-year mortality was evaluated using multivariate Cox regression analysis. RESULTS: Only one @entity1 had hs- @entity16894 level below the detection limit of the assay (<0.003ng/mL). The median hs- @entity16894 level was 0.025 (quartile 0.011-0.083)ng/mL. During the median follow-up period of 1782 days, 188 @entity1 died. Survival CART analysis revealed that the 1st, 2nd, and 3rd discriminating hs- @entity16894 levels to discern 5-year mortality were 0.028, 0.008, and 1.340ng/mL, respectively. The adjusted hazard ratios for the medium-low (0.009-0.028ng/mL), medium-high (0.029-1.340ng/mL), and high-risk (>= 1.341ng/mL) groups were 3.03 (95% confidence interval 1.18-7.77, p=0.021), 4.29 (1.63-11.28, p=0.003), and 8.68 (2.20-34.27, p=0.002), respectively. Integrated discrimination improvement (IDI) analysis revealed that incorporation of this hs- @entity16894 classification scheme with other clinical variables statistically improved the discriminatory accuracy for 5-year mortality, with a time-dependent IDI of 0.0076 (p=0.033). CONCLUSIONS: hs- @entity16894 levels at the convalescent stage were associated with long-term mortality in @entity583 @entity1 . Even subclinical elevation of hs- @entity16894 levels was associated with increased 5-year mortality.
