Activation of Endocannabinoid System Is Associated with Persistent Inflammation in @entity1 XXXX .

@entity1 @entity32 @entity449 @entity101 @entity6 @entity1476 @entity9394 @entity9395 @entity9393 @entity22078 @entity1426 @entity439 @entity6824 @entity453 @entity12020
@entity1 @entity449 have been associated with @entity32 and vascular remodeling. Since the endocannabinoid system modulates @entity32 and tissue remodeling, we investigated its components in @entity1 @entity449 . We obtained anterior aortic wall samples from @entity1 undergoing elective surgery for @entity449 or @entity453 as controls. Histological and molecular analysis (RT-qPCR) was performed, and endocannabinoid concentration was determined using LC-MRM. @entity1 characteristics were comparable between the groups except for a higher incidence of arterial @entity101 and @entity6 in the control group. mRNA level of cannabinoid receptors was significantly higher in @entity439 than in controls. Concentration of the endocannabinoid @entity9394 was significantly higher, while the second endocannabinoid @entity9393 and its metabolite @entity1426 and @entity9395 were significantly lower in @entity439 . Histology revealed persistent infiltration of newly recruited leukocytes and significantly higher mononuclear cell density in adventitia of the @entity439 . Proinflammatory environment in @entity439 was shown by significant upregulation of @entity6824 and PPARy but associated with downregulation of chemokines. We found comparable collagen-stained area between the groups, significantly decreased mRNA level of @entity12020 , osteopontin-1, and @entity1476 , and increased @entity22078 expression in @entity439 . Our data provides evidence for endocannabinoid system activation in @entity1 @entity449 , associated with persistent low-level @entity32 and vascular remodeling.
