The chromatin remodeling factor Bap55 functions through the XXXX complex to regulate olfactory projection neuron dendrite targeting.

@entity1 @entity72419 @entity6841 @entity21120 @entity72417 @entity15974 @entity23424 @entity24377 @entity72418 @entity238 @entity855
BACKGROUND: The @entity238 olfactory system exhibits very precise and stereotyped wiring that is specified predominantly by genetic programming. Dendrites of olfactory projection neurons (PNs) pattern the developing antennal lobe before olfactory receptor neuron axon arrival, indicating an intrinsic wiring mechanism for @entity6841 dendrites. These wiring decisions are likely determined through a transcriptional program. RESULTS: We find that loss of @entity23424 associated protein 55 kD (Bap55) results in a highly specific @entity6841 mistargeting phenotype. In Bap55 mutants, PNs that normally target to the @entity15974 glomerulus mistarget to the @entity72417 l glomerulus with 100% penetrance. Loss of Bap55 also causes derepression of a @entity21120 whose expression is normally restricted to a small subset of PNs. Bap55 is a member of both the @entity23424 ( @entity23424 ) and the @entity24377 ( @entity24377 ) @entity855 -dependent chromatin remodeling complexes. The Bap55 mutant phenotype is partially recapitulated by Domino and Enhancer of Polycomb mutants, members of the @entity24377 complex. However, distinct phenotypes are seen in @entity23424 and Snf5-related 1 mutants, members of the @entity23424 complex. The Bap55 mutant phenotype can be rescued by postmitotic expression of Bap55, or its @entity1 homologs @entity72418 and @entity72419 . CONCLUSIONS: Our results suggest that Bap55 functions through the @entity24377 chromatin remodeling complex to regulate dendrite wiring specificity in PNs. The specificity of the mutant phenotypes suggests a position for the @entity24377 complex at the top of a regulatory hierarchy that orchestrates dendrite targeting decisions.
