Effect of cytokine growth factors on the prevention of XXXX .

@entity4438 @entity5224 @entity3426 @entity810 @entity547 @entity35
Cytokine growth factor treatment of chronic wounds has met with mixed results. The chronic wound presents a hostile environment to peptides such as growth factors. Cytokine growth factors have not been studied extensively in acute wounds. However, incisional @entity547 are a major example of @entity810 that has not been solved by various mechanical approaches. A biological approach to @entity810 by use of cytokine growth factors may offer a new strategy. A rodent incisional @entity547 model was used. Seventy-six @entity35 underwent 3-cm midline celiotomies and were closed with fine, fast-absorbing sutures to induce intentional @entity810 . Group 1 received no other treatment. The midline fascia in Groups 2-10 was infiltrated with 100 microl of vehicle alone or vehicle containing various test cytokine growth factors. Necropsy was performed on postoperative day 28 and the wounds were examined for herniation. Incisional @entity547 developed in 83 percent (13/16) of untreated incisional and 88 percent (7/8) and 83 percent (5/6) of the two vehicle-treated incisions (PBS and @entity5224 ). @entity547 incidences were decreased by priming of the @entity4438 with transforming growth factor-beta(2) (12%, 1/8), basic fibroblast growth factor (25%, 2/8) and @entity3426 (50%, 3/6) (p < 0.05). Aqueous platelet-derived growth factor, becaplermin, insulin-like growth factor, and granulocyte macrophage-colony stimulating factor did not significantly decrease the incidence of @entity810 (p > 0.05). A biological approach to @entity810 as measured by incisional @entity547 formation can be useful in reducing the incidence of this complication. Transforming growth factor-beta(2), basic fibroblast growth factor, and @entity3426 all eliminated or significantly reduced the development of incisional @entity547 in the @entity35 model.
