Congenital anomalies associated with XXXX : A registry-based study in 16 European countries, 2000-2011.

@entity13797 @entity1 @entity1152 @entity3002 @entity5767 @entity735 @entity299 @entity204 @entity7440 @entity2241
The aim of this study was to examine the prevalence of trisomies 18 and 13 in Europe and the prevalence of associated anomalies. Twenty-five population-based registries in 16 European countries provided data from 2000-2011. Cases included live births, fetal @entity204 (20+ weeks' gestation), and terminations of pregnancy for @entity2241 (TOPFAs). The prevalence of associated anomalies was reported in live births. The prevalence of @entity7440 were 4.8 (95%CI: 4.7-5.0) and 1.9 (95%CI: 1.8-2.0) per 10,000 total births. Seventy three percent of cases with @entity7440 resulted in a TOPFA. Amongst 468 live born babies with trisomy 18, 80% (76-83%) had a @entity299 , 21% (17-25%) had a @entity3002 , 8% (6-11%) had @entity1152 and 10% (8-13%) had an @entity13797 . Amongst 240 Live born babies with trisomy 13, 57% (51-64%) had a @entity299 , 39% (33-46%) had a @entity3002 , 30% (24-36%) had @entity735 , 44% (37-50%) had @entity5767 and 45% (39-52%) had an @entity13797 . For babies with trisomy 18 @entity1 were less likely to have a @entity299 compared with @entity1 (OR   =   0.48 (0.30-0.77) and with trisomy 13 were less likely to have a @entity3002 [OR   =   0.46 (0.27-0.77)]. Babies with @entity7440 do have a high proportion of associated anomalies with the distribution of anomalies being different in @entity1 and @entity1 .
