Dental pulp-derived @entity18518   / @entity73063    side population stem/progenitor cells enhance recovery of focal XXXX in @entity35 .

@entity18518 @entity64 @entity73063 @entity2806 @entity63 @entity2500 @entity1188 @entity1391 @entity35
Regenerative therapy using stem cells is a promising approach for the treatment of @entity64 . Recently, we reported that @entity18518   / @entity73063    side population (SP) cells from porcine dental pulp exhibit highly vasculogenic potential in hindlimb @entity63 . In this study, we investigated the influence of @entity18518   / @entity73063    SP cells after @entity2500 ( @entity2500 ). Adult male @entity35 were subjected to 2   h of @entity2500 . Twenty-four hours after @entity2500 , @entity18518   / @entity73063    SP cells were transplanted into the brain. Motor function and @entity1188 volume were evaluated. Neurogenesis and vasculogenesis were determined with immunochemical markers, and the levels of neurotrophic factors were assayed with real-time reverse transcription-polymerase chain reaction. In the cell transplantation group, the number of doublecortin-positive cells increased twofold, and the number of NeuN-positive cells increased eightfold, as compared with the control @entity1391 -buffered saline group. The vascular endothelial growth factor level in the @entity63 brain with transplanted cells was 28 times higher than that in the normal brain. In conclusion, @entity18518   / @entity73063    SP cells promoted migration and differentiation of the endogenous neuronal progenitor cells and induced vasculogenesis, and ameliorated @entity2806 after @entity2500 .
