XXXX is associated with outcome of cardiac resynchronization therapy   .

@entity1 @entity712 @entity13678 @entity955 @entity5707
AIMS: To study the prognostic effect of @entity13678 on outcome of cardiac resynchronization therapy (CRT). METHODS AND RESULTS: @entity1 receiving a CRT device in the University Medical Centre Groningen were included. @entity13678 was defined as a >= 10% reduction in left atrial volume index at 6-month follow-up. Success of CRT was defined as ventricular reverse remodelling with a reduction in left ventricular end-systolic volume of >= 15% at 6-month follow-up. Primary endpoint was all-cause mortality or @entity712 hospitalizations. A total of 365 @entity1 (mean age 65.1    11.0 years, 73% @entity1 ) were included; among them, 221 (61%) were in sinus rhythm and had no prior @entity955 ( @entity955 ), and 144 @entity1 (39%) had a history of @entity955 . During a mean follow up of 2.0    1.0 years, 49 @entity1 died. Cox regression analysis revealed that @entity1 with no atrial and no ventricular reverse remodelling had the worst outcome (hazard ratio 3.1, 95% confidence interval 1.4-7.1, P = 0.006). Outcome in @entity1 with only @entity13678 was comparable with outcome in @entity1 with both @entity5707 (hazard ratio 2.0, 95% confidence interval 0.7-5.6, P = 0.21). CONCLUSION: @entity1 without @entity5707 have the worst outcome. @entity1 with only @entity13678 have improved left ventricular diastolic filling during follow-up and demonstrate a comparable outcome with @entity1 with both @entity5707 . Assessment of @entity13678 may provide additional prognostic information in determining CRT outcome.
