XXXX , a new polypeptide from Phyllomedusa sauvagei skin. Occurrence in various Phyllomedusa species and pharmacological actions on @entity35 blood pressure and diuresis.

@entity1169 @entity591 @entity3897 @entity35 @entity551 @entity73006
1. The occurrence of @entity73006 , a new polypeptide from amphibian skin, and its actions on @entity35 blood pressure and diuresis were studied. 2. @entity73006 was found to be present in the skin of all the 10 Phyllomedusa species so far studied, amounts ranging from a few micrograms to 240 micrograms per g fresh skin. 3. The polypeptide displayed in the @entity35 an intense, long-lasting @entity551 action accompanied by @entity591 . @entity551 was not modified by either @entity3897 or @entity1169 , excluding the participation of the autonomic nervous system in its production. @entity591 , on the contrary, was partially inhibited by @entity1169 . 4. @entity551 is probably the main cause of the intense antidiuresis seen in hydrated @entity35 following @entity73006 administration. Reduction in urina volume was accompanied by a decrease in GFR and an increase in tubular NA+ reabsorption.
