Prognostic Significance of Lymphatic Vessel Density Detected by D2-40 and Its Relation to @entity17290 Expression in XXXX .

@entity263 @entity5 @entity189 @entity17290 @entity3
BACKGROUND: Lymphovascular invasion is an important pathway of metastatic spread and regional lymph node @entity3 is the major prognostic factor in @entity263 . D2-40 is used to identify the lymphatic vessels and to assess the lymphatic vessel density (LVD). Expression of @entity17290 may be related to invasion and progression of @entity189 cells in several @entity5 . AIM: To evaluate intra- and peritumoral LVD through immunohistochemical expression of D2-40 in relation to @entity17290 expression and clinicopathological parameters in @entity263 . MATERIALS AND METHODS: Immunohistochemical staining procedure was performed on 53 paraffin-embedded blocks of radical prostatectomy specimens for @entity263 using anti D2-40 and @entity17290 antibodies. Sections were evaluated for mean LVD in intratumoral and peritumoral tissues assessed by D2-40 expression. RESULTS: LVD in intratumoral tissues was significantly lower compared with peritumoral areas (P = .0001). Peritumoral mean LVD was significantly higher in cases with @entity3 (P = .041) and in cases with positive lymph node @entity3 (P = .003) than intratumoral mean LVD. High @entity17290 expression was significantly correlated with high @entity5 grade (P = .0001), @entity3 (P = .006), and positive lymph node @entity3 (P = .004). High @entity17290 expression was significantly associated with increased mean LVD in peritumoral tissues. CONCLUSION: Increased peritumoral mean LVD in @entity263 is associated with @entity3 and positive lymph node @entity3 . High @entity17290 expression is associated with high @entity5 grade, lymphocascular invasion, positive lymph node @entity3 , and high mean peritumoral LVD suggesting that D2-40 and @entity17290 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis.
