The flavonoid monoHER promotes the adaption to oxidative stress during the onset of XXXX .

@entity1748 @entity9492 @entity10182 @entity19 @entity52484 @entity409 @entity2197 @entity3088 @entity1432 @entity1561 @entity165
@entity1561 ( @entity1561 ) is the most common @entity409 . An evidence-based pharmacological treatment for @entity1561 is still lacking, but @entity3088 have shown therapeutic potential. The present study was designed to investigate the effect of the flavonoid monoHER on the onset of @entity1561 in @entity1748 (-/-) @entity19 on a high-fat and high- @entity165 diet. The focus was put on the effect on oxidative stress as well as the adaptive response. Wild type @entity19 served as a control and the effect of monoHER was compared to that of a placebo. In the @entity1748 (-/-) group, monoHER provided only a mild protection against oxidative stress. In the placebo @entity1748 (-/-) group an adaptive response elicited by the @entity10182 antioxidant defense system was observed, evidenced by a higher HO-1 and @entity52484 gene expression, as well as an increased redox status, evidenced by the higher @entity2197 / @entity9492 ratio. In the monoHER treated @entity1748 (-/-) group both the adaptive response as well as the increase in redox status tended to be higher, although this did not reach significance on a group level. Unexpectedly, a strong within animal relationship was found that links a high adaptive response to a low redox status in the monoHER @entity1748 (-/-) group. This correlation was absent in the placebo and wild type group. The concept that emerges is that a @entity1432 -reactive oxidation product of monoHER, formed during oxidative stress, selectively induces the @entity10182 pathway and enforces the endogenous antioxidant shield, to provide protection against @entity1561 .
