Lipopolysaccharide receptor XXXX polymorphism and risk of @entity64 in a South-German population.

@entity1 @entity455 @entity64 @entity2806 @entity301 @entity5750 @entity731
BACKGROUND: The monocyte receptor for bacterial lipopolysaccharide @entity5750 is an important mediator of the inflammatory response. Recently, a polymorphism in the promotor of the @entity5750 gene, C (-260) T, was detected as a risk factor for @entity301 . OBJECTIVE: We tested the hypotheses that this polymorphism is a risk factor 1. for @entity2806 in general and 2. for @entity2806 due to large artery @entity731 or @entity455 in particular. @entity1 AND METHODS: We performed a case control study including 151 consecutive @entity1 with @entity2806 treated at our university hospital and 149 control subjects. All control subjects were randomly selected from the general population of the same region in South-West Germany. Genotype frequencies of the C(-260) T polymorphism in the promotor of the @entity5750 gene were examined by restriction length analysis. RESULTS: The TT-genotype was not associated with @entity2806 in general either in univariate or in multivariate analysis together with classical vascular risk factors (odds ratio in multivariate analysis: 1.11; 95 %CI, 0.63 to 1.95). In 70 @entity1 with @entity2806 due to @entity731 of large arteries or @entity455 , there was a significantly higher prevalence of the TT-genotype than into control subjects (38.6 % vs. 23.5 %; odds ratio in multivariate analysis 2.26; 95 %CI, 1.13 to 4.54). CONCLUSIONS: We demonstrated that the TT-genotype of the @entity5750 C(-260) T polymorphism in a South-German population is not associated with an increased risk of @entity2806 in general. However, we found that the TT-genotype is associated with a risk of @entity731 or microangiopathic @entity64 . This finding requires confirmation by future studies in larger populations.
