Rheolytic thrombectomy and platelet glycoprotein IIb/IIIa blockade for stent XXXX .

@entity1 @entity5892 @entity583 @entity1427 @entity715
Conventional transcatheter-based strategies result in good procedural success but poor clinical outcome in the treatment of intracoronary stent @entity715 . A combined approach of mechanical thrombus burden reduction using AngioJet rheolytic thrombectomy with adjunctive glycoprotein (GP) IIb/IIIa antagonists has not been studied. Between July 1998 and August 2000, 15 @entity1 (17 procedures) underwent AngioJet thrombectomy for stent @entity715 at the Beth Israel Deaconess Medical Center. @entity1 were followed clinically through 6 months following the AngioJet procedure. All @entity1 presented with signs of @entity583 at a median of 6 days following the original stenting procedure. Most vessels (88%) were occluded at presentation. A @entity1427 /IIIa inhibitor was administered during 16 of the 17 procedures. Rheolytic thrombectomy resulted in complete removal of filling defects in all reviewed cases and led to significant improvement in lumen diameter and TIMI flow with reduction in the @entity5892 length (all P values < 0.05). Angiographic success (< 30% residual stenosis, TIMI 3 flow) was attained in all but one procedure. No @entity1 required emergent coronary bypass grafting, repeat coronary angioplasty, or died in-hospital. At 6 months, there were no deaths and repeat revascularization was performed in four @entity1 (29%). A combined approach of rheolytic thrombectomy with adjunctive @entity1427 /IIIa blockade was highly effective in resolving stent @entity715 and was associated with favorable acute and long-term outcomes.
