Strategic approach to the management of @entity978 incorporating salvage therapy with high-dose @entity1260 , @entity2879 and XXXX : a Northern Region Lymphoma Group study (UK).

@entity1 @entity8 @entity137 @entity1259 @entity2879 @entity1398 @entity1260 @entity978
The Northern Region Lymphoma Group is a population-based group covering 3.1 million @entity1 in Northern England. From 1991 total data collection for all @entity978 @entity1 for this population has been in place and it has been possible to demonstrate that the overall survival for @entity978 for younger @entity1 within this population has moved from 80% pre- 1988 to 87% post- 1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 @entity1 treated with the @entity1260 , @entity2879 and @entity1259 (IVE)schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 @entity1 responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 @entity1 remain alive and in continuous remission. @entity137 ,in particular @entity1398 WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological @entity137 was not a major problem, with no significant @entity8 . We conclude that the high-dose @entity1260 -containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing @entity978 .
