Predictors of remission, normalized physical function, and changes in the working situation during follow-up of XXXX with early @entity309 : an observational study.

@entity1 @entity627 @entity283 @entity158 @entity309
OBJECTIVES: To evaluate possible predictors of remission, normalized physical function, and work change in @entity309 ( @entity309 ). METHODS: We determined in our early @entity309 cohort the proportion of @entity1 in remission [Disease Activity Score (DAS28)<2.6], with normalized function [ @entity283 ( @entity283 ) = 0], and with changed working situation since disease onset. Candidate predictors of remission, normalized function, and work change were studied by subgroup comparison and logistic regression analysis, including demographics, education, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, treatment, and DAS28, @entity283 , @entity158 (on the visual analogue scale, VAS). RESULTS: Median (interquartile range, IQR) disease duration was 18 (29) months. Of 89 @entity1 included, 69% were in remission. DAS28, @entity283 , @entity158 of these @entity1 were lower throughout year 1, although similar at baseline, compared to @entity1 not in remission. At month 4, more of these @entity1 were already good responders. Remission at month 4 independently predicted remission at follow-up. Thirty-eight per cent had no functional limitations; compared to @entity1 with limitations, they had a lower baseline @entity283 and lower DAS28, @entity283 , @entity158 during year 1. At month 4, more achieved remission or @entity283 = 0. Male sex, baseline @entity283 , and month 4 good European League Against @entity627 (EULAR) response predicted long-term @entity283 = 0, but month 4 @entity283 = 0 was the strongest independent predictor. Of the 40% with a paid job at baseline, 43.8% reported changes in their work situation; they had higher DAS28, @entity283 , @entity158 during year 1. Failing a month 4 good EULAR response independently predicted work change. CONCLUSION: Month 4 disease response predicts later remission, normalized physical function, and work change in @entity309 .
