A case of aggressive @entity3270 of the XXXX .

@entity1 @entity3883 @entity1087 @entity1819 @entity5 @entity409 @entity900 @entity16857 @entity420 @entity3270 @entity1487
An 18 cm x 16 cm x 10 cm @entity5 of the @entity1819 , invading the @entity409 , pancreatic body and tail, and transverse colon, with peritoneal deposits on the major omentum, was resected by total gastrectomy plus left hepatic lobectomy, transverse colectomy, distal pancreatectomy, splenectomy, and omentectomy. Histopathologically, the @entity5 consisted of large uniform cells with significant nuclear atypia, showing solid growth patterns with occasional small nests without @entity420 components. Immunohistochemical investigations of the neoplastic cells confirmed the @entity5 as a @entity3270 . molecular analyses disclosed loss of heterozygosity at the @entity16857 gene locus on chromosome 11q13. Recurrence occurred at the hepatic hilus and incurred @entity3883 months after surgery. Following percutaneous transhepatic biliary drainage, intensive chemotherapy (20 mg/m(2) @entity900 on days 1-5 div, 100 mg/m(2) etoposide on days 1, 3, and 5 div, and 800 mg/m(2) @entity1487 on days 1-5 bolus iv) was started. The recurrent @entity5 shrank dramatically, and could not be detected on image modalities after five courses of chemotherapy. The @entity1 was well and free of symptoms without biliary drainage for 5 months. Then he began to present with @entity1087 again, and died of acute massive dissemination 7 months after surgery. An aggressive form of @entity3270 has been known to be associated with an extremely poor prognosis. However, it is notable that treatment with extensive surgery and intensive chemotherapy could contribute to an improvement in quality of life even if the beneficial effect lasted for only half a year.
