Associations between cruciferous vegetable intake and selected biomarkers among XXXX scheduled for breast biopsies.

@entity1 @entity0 @entity5 @entity3544 @entity15688 @entity3997 @entity513 @entity1011 @entity8114
OBJECTIVE: To examine the relationship between dietary cruciferous vegetable intake and selected @entity5 biomarkers for histone acetylation (H3K9ac, H3K18ac, @entity3997 and @entity15688 ), proliferation (Ki-67) and cell-cycle regulation ( @entity3544 ) from breast tissue. DESIGN: The study used baseline data of @entity1 recruited to participate in a clinical trial of @entity8114 supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log2-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations between cruciferous vegetable intake and biomarkers adjusting for age and use of non-steroidal anti-inflammatory drugs. False discovery rate (FDR) was used to account for multiple comparisons. SETTING: Clinical trial baseline. SUBJECTS: Fifty-four @entity1 who had abnormal mammogram findings and were scheduled for breast biopsy. RESULTS: Mean intake of total cruciferous vegetables from all food sources was 81  7 (sd 57  3) g/d. Mean urinary total @entity8114 metabolites was 0  08 (sd 0  07)   m/mm @entity1011 . Total cruciferous vegetable intake was inversely associated with Ki-67 protein expression in @entity0 in situ (DCIS) tissue (b=-0  004; se=0  001; FDR q value=0  03), but not in benign or @entity513 ( @entity513 ) tissue. No association was found for other biomarkers measured ( @entity3997 , @entity15688 , H3K9, H3K18 and @entity3544 ) in all tissues examined (benign, DCIS and @entity513 ). CONCLUSIONS: The present study sought to provide additional evidence for the potential role of @entity8114 in histone acetylation and cell proliferation. Here, we report that total cruciferous vegetable intake is associated with decreased cell proliferation in breast DCIS tissue.
