Dopa therapy and action impulsivity: subthreshold error activation and suppression in XXXX .

@entity1 @entity121 @entity191
RATIONALE: Impulsive actions entail (1) capture of the motor system by an action impulse, which is an urge to act and (2) failed suppression of that impulse in order to prevent a response error. Several studies indicate that dopaminergic treatment can induce action impulsivity in @entity1 diagnosed with @entity191 ( @entity191 ). Whether this effect is due to increased impulse expression or to decreased impulse suppression remains to be deciphered. METHOD: We used a novel approach based on electromyographic (EMG) analyses to decipher the effects of the @entity1 's usual dopaminergic therapy on the expression and suppression of subliminal erroneous impulses. To this end, we used a within-subject design and took advantage of the Simon task, that elicits prepotent response tendencies. The @entity1 (N   =   15) performed the task on their usual dopaminergic medication and after complete medication withdrawal (for at least 12  h). RESULTS: The correction rate that measures the ability to suppress subthreshold @entity121 was lower when the @entity1 were on medication as compared to their off medication state (p   <   0.05). The incorrect activation rate that measures the capture of the motor system by action impulses was unaffected by medication. CONCLUSIONS: Dopa therapy affected action impulsivity. Although medication did not influence the incidence of fast action impulses, it significantly reduced @entity1 ' ability to abort and suppress muscle activation related to the incorrect response alternative.
