Cerebral acidosis in focal ischemia: II. @entity3931 and @entity1855 normalize cerebral pH following @entity2500 in the XXXX .

@entity2806 @entity2500 @entity1855 @entity3931 @entity4770 @entity1188 @entity460 @entity35
The effects of @entity4770 , @entity3931 , and @entity1855 on local cerebral pH (LCpH) and CBF (LCBF) in @entity2500 ( @entity2500 )-occluded @entity35 were compared with those in controls and others receiving @entity3931 carrier. LCpH and LCBF were determined simultaneously by a double-label autoradiographic technique. The infusions were intravenous, started 15 min following the occlusion, and ended at decapitation 4 h postocclusion. The dosages were 0.5 micrograms/kg/min for @entity3931 , 40 micrograms/kg/min for @entity1855 , and 5 ng/kg/min for @entity4770 . Cortical LCpH in the @entity2500 territory of control and carrier-infused @entity35 varied between 6.72 +/- 0.05 and 6.76 +/- 0.05 (means +/- SEM). These values were significantly lower than the LCpH in the same structures in the contralateral hemisphere (7.09 +/- 0.06; p less than 0.05). LCBF on the side of occlusion varied between 54 +/- 5 ml/100 g/min for the parietal and 57 +/- 7 ml/100 g/min for the sensorimotor cortex, while on the contralateral side, LCBF in these same structures was 190 +/- 18 and 191 +/- 4 ml/100 g/min, respectively. LCpH was not modified by @entity4770 treatment following @entity2500 occlusion, but the pH in the structures that were acidotic in the controls became indistinguishable from contralateral values in @entity3931 - and @entity1855 -treated animals. In contrast, LCBF was statistically higher than controls in many structures only in @entity35 treated with @entity4770 . This suggested that the correction of LCpH produced by @entity460 blockers was not related to an effect they had on blood flow. Animals receiving @entity460 blockers tended to have smaller areas of @entity1188 . These results may have therapeutic implications in @entity2806 .
