Expression of XXXX and Tumor Microvessel Density in @entity14 .

@entity1 @entity5 @entity3840 @entity7453 @entity14 @entity2247 @entity694 @entity420
PURPOSE: The increased expression of @entity2247 has been implicated in the development and progression of @entity1 @entity5 . This study investigated the @entity2247 expression in @entity14 , and its relationships with @entity5 angiogenesis and the clinicopathological factors. MATERIALS AND METHODS: The expression of the @entity2247 protein and microvessel density were evaluated, using immunohistochemical methods, in 21 normal colonic mucosa and 190 @entity1 @entity14 . Correlations between @entity2247 expression and microvessel density, as well as various clinicopathological factors, were studied in @entity14 . RESULTS: The @entity2247 protein expression in epithelial cells was increased in 169 of the 190 @entity420 cases (88.9%), but in only 1 of the 21 (4.8%) normal mucosa cases. The @entity2247 expression was significantly increased in the differentiated compared with the undifferentiated @entity14 (p<0.05), and significantly correlated with the depth of invasion and microvessel density (p<0.05). @entity5 had more @entity2247 positive cases than the @entity694 (p<0.05). However, there were no significant differences in the @entity5 size and the presence of @entity7453 . CONCLUSION: The overexpression of @entity3840 in @entity14 seems to play a role in the invasion and angiogenesis of the @entity5 , so may be a useful marker of the prognosis. The prominent expression was also demonstrated in differentiated @entity14 .
