Galectin-3 and XXXX Immunohistochemistry and Tumor Dimensions Are Useful in Distinguishing Follicular Oncocytic Carcinomas from Oncocytic Adenomas of the Thyroid.

@entity5 @entity29624 @entity2513 @entity18923
UNASSIGNED: Aims. Oncocytic (Hurthle) follicular cell @entity5 (OTs) of the thyroid are both @entity2513 (OCs). The routine diagnosis of these @entity5 can be problematic even after an accurate sampling and histological examination. Beside preoperative evaluation due to the @entity5 's dimension several studies have been performed to find markers able to distinguish malignant from @entity5 in the thyroid, with Galectin-3 being one of the most effective. Recently, some authors suggested @entity18923 as adjunct to the diagnosis of the oncocytic lesions of the thyroid. Methods and Results. In this paper we assess the role of Galectin-3 and @entity18923 in a well-selected group of follicular oncocytic @entity5 (14   OCs and 26   @entity29624 ). The diameter of each lesion was also evaluated. The combination of Galectin-3 and @entity18923 has a good specificity (81%) and sensitivity (100%). Moreover, the maximum diameter (in cm) of OCs is greater than @entity29624 (4.1 versus 2.3). Conclusions. We believe that the use of Galectin-3 and @entity18923 in OTs of the thyroid can be a helpful panel in daily practice when histology is doubtful.
