Comparative protective effects of @entity3360 , @entity4271 , @entity38763 and XXXX against ischaemic injury in the hippocampus of the Mongolian gerbil.

@entity1399 @entity3931 @entity3360 @entity38763 @entity4271 @entity528
1. Morphological changes characterizing delayed @entity528 (DND) of selectively vulnerable @entity1399 pyramidal cells in the hippocampus of the Mongolian gerbil brain occurred 72 h after transient (5 min) bilateral occlusion of the common carotid arteries. 2. Different groups of animals were treated 15 min before carotid artery occlusion and twice daily during the 72 h post-ischaemia period with either saline alone, @entity3360 , @entity4271 , @entity38763 or @entity3931 at doses of 500 micrograms kg-1 intraperitoneally. 3. At 72 h the animals were killed and their brains examined histologically. Absolute cell counts were made from 5 sites distributed linearly throughout the hippocampal @entity1399 subfield in each hemisphere to determine the percentage DND in each group. Normal brains and those of sham-operated animals were included in the study for comparison. 4. Features of DND were distributed evenly throughout the @entity1399 subfield in both hemispheres in all groups of gerbils. @entity3360 , @entity38763 and @entity4271 , but not @entity3931 , were protective. This protection extended linearly throughout the hippocampus without altering the pattern of @entity528 . 5. Compared to saline-treated (78.3 +/- 2.9% DND) and @entity3931 -treated (76.5 +/- 3.4% DND) gerbils, the overall protection afforded by @entity3360 (41.8 +/- 3.8% DND) was statistically significant. The effects of @entity38763 (53.6 +/- 7.1%) and @entity4271 (55.8 +/- 3.9% DND) were of borderline significance. 6. Abnormal neurones appeared in normal and sham-operated brains to the extent of 4.5 +/- 1.0% and 4.6 +/- 0.4%, respectively. Such changes can be attributed to fixation artefacts. 7. The results demonstrate that overall protection is conferred on ischaemic hippocampal @entity1399 neurones by @entity3360 and to a lesser extent by @entity4271 and @entity38763 , but not by @entity3931 .
