Natural killer (NK) cell activity and reversal reaction in XXXX .

@entity1 @entity3761 @entity5117 @entity1201 @entity1203
Two studies were conducted to assess natural killer (NK) cell activity in @entity1201 @entity1 and healthy Ethiopian controls. The first study tested 26 untreated @entity1201 @entity1 across the spectrum of the disease. It was found that @entity1203 and all untreated, nonreactional @entity1 had lower NK activity than healthy controls. However, @entity1 presenting with reversal reaction (RR) had NK activity within the normal range. Heterogeneity was particularly marked in the NK activity of borderline @entity1 . In the second study, NK cell activity was assessed in treated @entity5117 ( @entity5117 ) @entity1 . There were 30 @entity1 with a history of RR and 27 @entity5117 @entity1 without such a history (NR). All @entity1 had had at least 3 years of @entity3761 treatment and 6 months of multidrug therapy. There were 26 control subjects. NK activity was higher in controls than in @entity1 only at one effector:target (E:T) ratio tested, but NK cells from the @entity5117 @entity1 group appeared to be more "aggressive" in that there was significantly (p less than 0.001) less reduction of activity with dilution of effector cells. There were no significant differences in NK activity between RR and NR @entity1 . The NK activity of NR @entity1 was positively correlated with the size of induration of the lepromin response. We conclude that higher NK activity in acute RR would appear to be a consequence rather than a cause of reversal reactions.
