Pan_02 XXXX @entity788 model.

@entity1 @entity788 @entity39 @entity19 @entity5
AIM: The aim of this study was to investigate and describe basic features of Pan_02 @entity19 pancreatic ade- nocarcinoma @entity5 model. Pan_02 has very low sensitivity to chemotherapeutics therefore it is very similar to @entity1 @entity788 . MATERIALS AND METHODS: @entity19 were subcutaneously injected with different number of cells and @entity5 growth was measured. @entity5 were also investigated with ultrasonograph VEVO2100 in doppler mode to detect viable and function- al blood vessels. @entity5 samples were investigated to asses @entity39 and blood vessel permeability. RESULTS: We found substantial differences in @entity5 growth depending on a number of inoculated @entity5 cells. @entity19 injected with 0.5 * 106 cells gave the most consistent pattern of growth. All @entity5 showed substantial vascularisation but bigger @entity5 were more likely to develop larger blood vessels instead of a more dense network. CONCLUSIONS: @entity19 Pan_02 @entity5 model shares many features with @entity1 @entity5 and therefore it is a good model to study new drugs. Injection of 0.5 * 106 cells gives consistent results although it requires more time for the @entity5 to grow. It also allows the immune system to adapt. Owing ta good vascularisation, Pan_02 is a good model to study chemotherapy against @entity788 but it may not be the best model for immunotherapy since it does not respond to the immune stimulation (unpublished data).
