@entity1 telomerase reverse transcriptase regulates XXXX expression via @entity1082 oncogene E7 in @entity5 cells.

@entity1 @entity7 @entity5 @entity1082 @entity3 @entity1613 @entity2215
@entity1082 ) @entity1613 and results in @entity3 . @entity1 telomerase as well as inflammatory and angiogenic factors such as telomerase reverse transcriptase ( @entity2215 ) or @entity7 ( @entity7 ) could play a role in regulating HPV-induced @entity5 . This study investigated underlying molecular events in HPV-induced @entity5 through @entity2215 and @entity7 in vitro. Expressions of @entity2215 , and @entity7 mRNA and proteins were, respectively, assessed by qRT-PCR, ELISA, and TRAP-ELISA in @entity5 cell lines. To assess @entity2215 and @entity7 secretion, @entity2215 overexpression and knockdown were conducted in HPV-18-positive Hela cells by @entity2215 cDNA and shRNA transfection, respectively. Then, the effect of HPV E6 and E7 on @entity7 expressions was assessed in @entity5 cells. Data have shown that @entity7 expression levels are associated with @entity2215 expressions and telomerase activity in @entity5 tissues and cells. Knockdown of @entity2215 expression down-regulated @entity7 expressions, whereas overexpression of @entity2215 up-regulated @entity7 expressions in HPV-18-positive Hela cells. Furthermore, HPV E7 oncoprotein was necessary for @entity2215 to up-regulate @entity7 expressions in @entity5 cells. Data from this current study indicate that HPV oncoproteins up-regulated @entity2215 and telomerase activity and in turn promoted @entity7 expressions, which could be a key mechanism for HPV-induced @entity5 development and progression.
