An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of XXXX .

@entity1 @entity32 @entity66 @entity6 @entity28 @entity731 @entity65
When @entity65 are viewed from an evolutionary biology perspective, a heightened thrifty and an inflammatory design could be their mechanisms. @entity1 ancestors confronted a greater infectious load and were subjected to the selection for proinflammatory genes and a strong inflammatory function. Ancestors also faced starvation periods that pressed for a thrifty genotype which caused fat accumulation. The pressure of sustaining gluconeogenesis during periods of poor nourishment selected individuals with insulin resistance. Obesity induces a proinflammatory state due to the secretion of adipokines which underlie @entity66 . Our actual lifestyle needs no more of such proinflammatory and thrifty genotypes and these ancestral genes might increase predisposition to diseases. Risk factors for @entity731 and @entity6 are based on inflammatory and genetic foundations that can be accounted for by excess fat. Longevity has also increased in recent times and is related to a proinflammatory response with cardiovascular consequences. If @entity1 ancestral lifestyle could be recovered by increasing exercise and adapting a calorie restriction diet, @entity28 would decrease and the effects on chronic low-grade @entity32 would be limited. Thereby, the rates of both @entity731 and @entity6 could be reduced.
