A surveillance of nosocomial candida XXXX : epidemiology and influences on mortalty in intensive care units.

@entity1 @entity9841 @entity6923 @entity4963 @entity5132 @entity281 @entity325 @entity4854
INTRODUCTION: It was aimed to investigate the frequency of @entity6923 ( @entity6923 ) in the intensive care units (ICU), to determine typing of candida to evaluate risk factors associated with @entity6923 and mortality, and to evaluate influence of @entity6923 on mortality. METHODS: The prospective cohort study was carried out between Jan 1, 2009 and Dec 31, 2010 in ICUs, and the @entity1 were observed with active surveillance. VITEK 2 Compact System (BioMerieux, France) kits were used for the identification of isolates from various clinical samples. RESULTS: A total of 2362 @entity1 had enrolled for 16135 @entity1 -days into the study. During the study, 63 (27,5%) of @entity1 developed 77 episodes of @entity6923 were observed. Of the @entity1 ; 54% were male, 46% were female. Duration of hospitalization (OR = 1,03, p = 0,007), @entity4854 (OR = 17,93, p = 0,009), and @entity325 (OR = 3,98, p = 0,001) were identified as independent risk factors for @entity6923 . The most common @entity281 were bloodstream (53%). 77 of 135 candida strains was isolated as causative pathogens. @entity5132 (63,6%) was the most frequent species. Overall mortality rate was 78%. The rates of mortality attributable to @entity6923 and @entity4963 were 27%, and 18,3% respectively. Species- specific mortality rates of @entity5132 and @entity9841 were determined as 12%. High APACHE II scores (OR = 1,37; p = 0,002), and the use of central venous catheter (OR = 9,01; p = 0,049) were assigned as independent risk factors for mortality. CONCLUSION: @entity6923 is an important problem in our hospital. @entity6923 and associated mortality can be prevented by controlling of risk factors. Updating of epidemiological data is required for successful antifungal treatment.
