Pediatric de novo XXXX : report of two cases and review of literature.

@entity1 @entity7026 @entity410 @entity2758 @entity16 @entity531
PURPOSE: @entity7026 ( @entity2758 ) is traditionally thought of as a congenital diagnosis. In recent years, there has been infrequent reports of this @entity531 presenting as de novo entities. METHODS: The authors report two cases of pediatric @entity1 who present with de novo cerebral AVMs. In both cases, the @entity1 had magnetic resonance imaging (MRI) of the brain done as part of the work-up for first-onset @entity410 . At that point in time, the scans were unremarkable. After a latent period of approximately 6 and 9  years respectively, a repeated MRI brain scan showed evidence of de novo @entity2758 for each @entity1 . RESULTS: Both @entity1 did not have radiological evidence of @entity7026 during their first presentation of @entity410 . However, a repeated MRI brain scan after a period of 6 and 9  years demonstrated new findings of @entity7026 for each @entity1 . CONCLUSIONS: Currently, the disease of cerebral de novo @entity2758 remain as an ambiguous condition that is poorly understood. With the advances in molecular diagnostics, there are possibilities of exploring biochemical profiles for better understanding of the origin of cerebral AVMs. However, in the meantime, owing to the unpredictable nature of cerebral AVMs, clinicians should have increased awareness of this unique condition. This is especially important, as definitive treatment is available to prevent devastating @entity16 from @entity7026 .
