Radiotherapy for XXXX : Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program.

@entity1 @entity137 @entity2946 @entity3
AIM: We retrospectively analyzed our Institution experience with these @entity1 . The endpoints of the analysis were overall survival (OS), disease-free survival (DFS), local control (LC), @entity3 ( @entity3 ); results were compared with the literature. BACKGROUND: @entity2946 in adult @entity1 is a very rare disease; the 5 and 10-year overall survival rates range between 33-78% and 27-56%, respectively. The collection of more clinical data is strongly needed. MATERIALS AND METHODS: From September 1975 to October 2006, we treated 16 adult @entity1 (9 males and 7 females) with a histological diagnosis of @entity2946 . @entity137 were scored according to RTOG @entity137 scale. Karnofski performance status (KPS) and neurological performance status (NPS) pre- and post-RT were reported. Median age was 27 years (range 18-53 years). All the @entity1 received cranio-spinal irradiation, two @entity1 were also given chemotherapy. Median follow-up period was 121.5 months. RESULTS: In January 2014, 10/16 @entity1 were alive without evidence of disease, 6/16 died with progressive disease (1 local and spinal, 3 spinal and 2 extraneural). Ten-year LC, OS, DFS, @entity3 were, respectively, 84%, 67%, 60% and 59%. Univariate analysis shows that gross total resection is associated with better survival. No acute or late G3-G4 @entity137 was observed. CONCLUSIONS: This experience and the analysis of the literature confirm the efficacy of postoperative RT but also the need of large datasets to better define prognostic factors and the possible role of the association of chemotherapy.
