An evaluation of the effectiveness of hyaluronidase in the selective nerve root block of XXXX : a double blind, controlled clinical trial.

@entity1 @entity717 @entity614 @entity158
STUDY DESIGN: Prospective, double-blind, randomized controlled trial. PURPOSE: To determine the ability of hyaluronidase to provide longer lasting @entity158 relief and functional improvement in @entity1 with @entity614 . OVERVIEW OF LITERATURE: Selective nerve root block (SNRB) is a good treatment option in @entity614 . We studied the effectiveness of hyaluronidase when added to the traditional SNRB regimen. METHODS: A sample size of 126 @entity1 per group was necessary. A sample of 252 @entity1 who underwent an injection procedure with or without hyaluronidase due to @entity614 was included in this study. The @entity1 were randomly divided into two groups: the control (C) group and the hyaluronidase (H) group. After SNRB due to @entity614 , the visual analog scale (VAS) was compared at 2, 4, 6, 8, and 12 weeks between the two groups, and the @entity717 index (ODI) was compared at 12 weeks between the two groups. RESULTS: Both groups seemed to have general improvement in VAS, but in C group, the VAS was higher than the H group 2 and 4 weeks after the surgery, and the difference in time-group change between 2 groups was statistically significant (p <0.05). ODI improved in both groups, and the difference in time-group change between 2 groups was not statistically significant (p >0.05). CONCLUSIONS: The rebound @entity158 (the re-occurrence of @entity158 within 2-4 weeks after injection) that occurs within 2-4 weeks after the injection of the routine regimen can be reduced when hyaluronidase is added to the routine SNRB regimen.
