[Clinical significance of the measurement of the urinary concentration of XXXX in differentiating @entity1374 from @entity2743 ].

@entity1 @entity1496 @entity2743 @entity1011 @entity1374
In order to differentiate @entity1374 ( @entity1374 ) from @entity2743 , the usefulness of the measurement of the urinary concentration of @entity1496 was evaluated in this study. The subjects employed were 39 @entity1 with @entity1374 and 40 @entity1 with @entity2743 . @entity1 were advised to avoid any @entity1496 -containing food or medication for a week before the examination. The urinary concentration of @entity1496 (UI) and the serum concentration of thyroid hormones were determined. UI was calculated from the amount of @entity1496 in the spot urine by multiplying it by the ratio of @entity1496 to @entity1011 . Since the UI value thus obtained was significantly well correlated with the UI value for 24 hour urine, the former value was used instead of the latter value thereafter. Mean UI value in the @entity1 with @entity1374 was 482.4 +/- 296.4 mu g/day and that in the @entity1 with @entity2743 was 169.8 +/- 75.2 mu g/day, the former value being significantly higher than the latter (p < 0.0001). A strong and significant correlation between UI and the serum concentration of FT4 or T3 (TT3) was found in the @entity1 with @entity1374 (r = 0.76, p < 0.0001 and r = 0.54, p < 0.02), but not in those with @entity2743 (r = 0.34, p = 0.07 and r = 0.24, p = 0.14) Mean UI/FT4 ratio and mean UI/TT3 ratio was significantly higher in @entity1 with @entity1374 than those with @entity2743 and the overlaps in the ratios between these two groups were very slight. These results indicate that both the ratios of UI/FT4 and UI/TT3 were useful parameters to differentiate @entity1374 from @entity2743 . The higher UI value observed in the @entity1 with @entity1374 was thought to be due to the increase in the amount of inorganic @entity1496 which was liberated from the iodinated material leaked from the damaged thyroid tissue by the deiodinating mechanism in the peripheral tissues.
