Correlation of locomotor activity and brain infarction in XXXX with transient focal ischemia.

@entity5045 @entity64 @entity2500 @entity1188 @entity35
Occlusion of @entity2500 (MCAo) is commonly used to generate @entity64 in experimental animals. Different behavioral assays have been used to evaluate the severity of lesions or recovery after treatment in this model. In this study, we examined the correlation between the size of @entity1188 after transient MCAo in adult @entity35 . The right @entity2500 was occluded for 30-90-min by ligation with a 10-O suture. At 2 days after MCAo, animals were individually placed in a 3-D infrared activity chamber for 1h to measure their horizontal, vertical, stereotypic and rotational activity. Body asymmetry was examined using an elevated body swing test. Volume of @entity1188 was measured by @entity5045 staining. We found that there is a significant correlation between the volume of @entity1188 , such as vertical activity, vertical movement number and vertical movement time. There is also a significant correlation between the @entity1188 volume and body asymmetry. In conclusion, our data suggest that vertical locomotor activity and body asymmetry are useful behavioral indices to estimate the size of lesioning in rodents after MCAo.
