Estimated volume growth characteristics of XXXX undergoing active surveillance.

@entity1 @entity5 @entity1358 @entity3 @entity703
INTRODUCTION: The detection rate of incidental renal masses is increasing. Historically these masses have been treated with extirpative surgery. Hence, there is little information on the growth rate, metastatic potential, and natural history of @entity703 . Through active surveillance, we study the natural history of renal masses and determine their growth rate and risk for @entity3 . MATERIALS AND METHODS: From 1997 to 2007, active surveillance was offered to select @entity1 with renal masses with no evidence of @entity3 . Based on imaging studies from the initial diagnosis to the last follow up, @entity5 growth rates were determined. RESULTS: Forty-six @entity1 were studied for a total of 58 masses. Mean age of @entity1 at diagnosis was 64.3 years. Mean Charlson comorbidity score was 5.2 (median 5, range 2-13). Mean follow up period was 22 months (median 17, range 5-121). Mean initial @entity5 volume was 6.6 cm3 (median 2.7, range 0.03-43.2). Mean growth rate was 1.9 cm3/yr (median 0.1, range -3.8-27.9), and 6.8% had a volume doubling time of less than 1 year. No @entity1 developed radiographic evidence of @entity3 or died during follow up. Thirteen @entity1 (15 masses) went onto operative intervention at a mean follow up of 19 months (median 18, range 4-36); 10/15 (67%) revealed @entity1358 and 5/15 (33%) were benign. CONCLUSIONS: In our cohort, negligible growth rates are observed in the vast majority of renal masses undergoing active surveillance, and thus, a carefully selected @entity1 population may be safely managed with active surveillance with serial imaging.
