The XXXX 399Gln polymorphism and the frequency of @entity876 mutations in Taiwanese @entity957 .

@entity1 @entity5 @entity167 @entity957 @entity20322 @entity20319 @entity535 @entity534 @entity876 @entity72539 @entity7647
DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity5 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity72539 polymorphism in the DNA repair gene @entity20319 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity5 development. Two hundred thirty-seven @entity957 ( @entity957 ) were included in a study to investigate the role of the @entity20319 194Trp, 280His, and 399Gln polymorphisms on @entity876 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity876 gene (exons 5-9). The @entity20319 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity957 had a @entity7647 / @entity7647 genotype. One hundred six (43.88%) of the 237 @entity957 showed @entity876 gene mutations at exons 5-9. The OSCC @entity1 with a @entity7647 / @entity7647 genotype exhibited a significantly higher frequency of @entity876 mutation than those with an @entity534 / @entity7647 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity167 drinking, the @entity7647 / @entity7647 genotype still showed an independent association with the frequency of @entity876 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity20319 @entity20322 @entity535 change may alter the phenotype of the @entity20319 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity20319 399Gln polymorphism in @entity876 gene mutation in Taiwanese @entity957 .
