XXXX is associated with increased circulating bone marrow-derived progenitor cells.

@entity1 @entity459 @entity6826 @entity1261 @entity63 @entity5 @entity7 @entity1570 @entity1195 @entity1307 @entity2279 @entity2280 @entity461 @entity436
Recently, @entity461 ( @entity461 ) was shown to support survival of progenitor cells in bone marrow. The release of progenitor cells occurs in physiological and pathological conditions and was shown to contribute to neovascularization in @entity5 and @entity63 tissues. In the present study we sought to investigate prospectively the effect of @entity459 ( @entity459 ) on mobilization of bone marrow-derived progenitor cells. In 22 @entity1 with @entity459 and 10 controls, defined subpopulations of circulating bone marrow-derived progenitor cells (BMCs) were analyzed by flow cytometry ( @entity1195 (+)/ @entity2280 (+)/ @entity2279 (+) cells indicating endothelial progenitor cells, @entity1195 (+)/ @entity2280 (+)/c-kit(+) cells indicating hematopoietic stem cells, and @entity1195 (+)/ @entity2280 (+)/ @entity436 (+) cells indicating progenitor cells with the homing receptor @entity436 ). Cytokine serum levels ( @entity6826 , @entity1570 , @entity7 , @entity1307 , and @entity1261 ) were assessed using ELISA. Levels of @entity461 and thyroid hormone as well as serum electrolytes, renal and liver parameters, and blood count were analyzed. Our data show for the first time a significant increase of circulating BMCs and an upregulation of @entity1570 and @entity7 serum levels in @entity1 with @entity459 . The number of circulating BMCs returned to control levels measured 16.7 +/- 2.3 mo after surgery. There was a positive correlation of @entity461 levels with the number of @entity1195 (+)/ @entity2280 (+)/ @entity2279 (+), @entity1195 (+)/ @entity2280 (+)/c-kit(+), and @entity1195 (+)/ @entity2280 (+)/ @entity436 (+) cells. However, there was no correlation between cytokine serum concentrations ( @entity1570 , @entity7 ) and circulating BMCs. Serum levels of @entity1261 , @entity1307 , and @entity6826 known to mobilize BMCs were even decreased or remained unchanged, suggesting a direct effect of @entity461 on stem cell mobilization. Our data suggest a new function of @entity461 mobilizing BMCs into peripheral blood.
