Influence of one human XXXX mismatch on outcome of allogeneic bone marrow transplantation from related donors.

@entity1 @entity281 @entity1500 @entity1349 @entity204 @entity4107
This study compares the clinical outcomes of 60 consecutive @entity1 who received an allogeneic blood or marrow stem cell transplant (BMT) from one Human @entity4107 (HLA) mismatched related donors with those of 120 matched @entity1 who had HLA identical sibling donors. The control @entity1 were matched for diagnosis, disease status, conditioning regimen, and age at BMT. All @entity1 received standard CYA and @entity1500 for GVHD prophylaxis. The probability of @entity1349 ( @entity1349 ) at 5 years was 35% in the study group compared to 56% in the control group. The relapse rates and acute GVHD rates did not differ between the two groups. Graft failure was a significant problem in the study group compared to the control group (13 vs. 0%, p < 0.0001). All cases of graft failure occurred in @entity1 with a mismatch in the host-versus-graft direction. BMT-related @entity204 were also increased in the study group. Forty percent of @entity204 were caused by infection in the study group vs. 19% in the control group (p < 0.01). In conclusion, the @entity1349 of @entity1 receiving marrow/stem cells from one antigen mismatched related donors was inferior to that of controls with HLA-identical related donors. There was an increase in mortality related to @entity281 occurring in the setting of an increased frequency of graft failure in these @entity1 .
