Reduced frequency and severity of ketoacidosis at diagnosis of childhood XXXX in Northwest Saudi Arabia.

@entity1 @entity1723 @entity6
BACKGROUND: Raising the awareness of childhood @entity6 symptoms can reduce the frequency of @entity6 ( @entity6 ) at onset of @entity1723 ( @entity1723 ). However, data on the effectiveness of such interventions are limited. The aim of the study was to describe trends of @entity6 at onset of childhood @entity1723 during 2005-2014 and assess the impact of a @entity6 campaign launched late 2010. METHODS: Data of @entity1 <12 years presented with @entity6 at diagnosis were analyzed according to age, gender and year of diagnosis. The frequency and severity of @entity6 before and during the 4 years campaign were compared. RESULTS: During 2005-2014, 44.9% (243/541) of @entity1 diagnosed with @entity1723 presented with @entity6 . Of these, 22.7% had pH <7.1. In both genders @entity6 was higher in @entity1 <6 years (47.8% vs. 40%; p<0.01) and more severe in <3 years old compared to older @entity1 (30% vs. 20%; p<0.01). Following the awareness campaign @entity6 rate dropped from 48% in 2010 to 39% in 2014 and 15.8% had severe @entity6 compared to 26.1% in 2005-2010 (p<0.01). This trend was observed in both genders and across age groups. In @entity1 <3 years the reduction in @entity6 frequency and severity was not statistically significant (p=0.15 and p=0.42, respectively). CONCLUSIONS: In NWSA, the frequency and severity of @entity6 at onset of childhood @entity1723 were reduced following 4 years awareness campaign; but the rate is still high. Maintaining the campaign may result in further improvement following a longer period of observation.
