Structural correlates for XXXX in early relapsing remitting @entity15 .

@entity1 @entity308 @entity73 @entity1295 @entity15
OBJECTIVES: Fatigue is a common symptom in @entity15 ( @entity15 ) @entity1 , even early in the disease, but the pathophysiology remains unclear. We aimed to determine morphologic and microstructural correlates and neuropsychological @entity73 in early relapsing-remitting @entity15 @entity1 . METHODS: Seventy-nine early relapsing-remitting @entity15 @entity1 (38 with @entity1295 and 41 without), none of whom suffered from @entity308 , underwent neuropsychological testing. Magnetic resonance imaging was performed using anatomical and diffusion tensor imaging sequences on all @entity1 and 40 controls. Voxel-based morphologic analysis and tract-based spatial statistics were performed. RESULTS: Only @entity1 with cognitive @entity1295 , but not those without, exhibited alterations in the thalamic region, showing reduced thalamic fractional anisotropy and increased mean diffusivity values. No differences in lesion volume and lesion distribution were observed between @entity1 groups. In cognitive tests, no significant differences were found between the two groups in the number of @entity1 with pathologic scores; however, subjective @entity73 differed. CONCLUSION: Morphological alterations and distinct microstructural changes (mainly in the thalamus) but not typical @entity15 were found to be related to cognitive @entity15 . We suggest that compensatory processes adapting to these changes could initially facilitate normal cognitive performance, but also result in a feeling of @entity1295 . KEY POINTS:     Morphological alterations and microstructural changes are related to @entity1295 in @entity15     Thalamic alterations in particular were related to @entity15     Fatigued @entity1 exhibited subjective but not measurable @entity73     Compensatory processes help preserve or maintain cognitive performance but also contribute to @entity1295 .
