XXXX T cells induce their own regulation through activation of B cells.

@entity1 @entity2937 @entity404 @entity1075 @entity19 @entity7938 @entity2936 @entity1252 @entity11707 @entity5893 @entity3053 @entity403 @entity2902 @entity688 @entity792
Regulatory functions for B lymphocytes have been reported in @entity19 models of @entity792 in which B-cell deficient @entity19 were shown to exhibit exacerbated disease. The B cells responsible for the immune regulations were identified as a subpopulation of @entity688 -secreting cells. However, the mechanism of induction and the characteristics of regulatory B cells in @entity1 have been hardly studied. This study reports that regulation of T cell responses can be induced by B cells following @entity2936 -dependent cognate interaction. T cell proliferation and cytokine production were differentially regulated. Thus, @entity2936 -induced regulatory B cells partially inhibited T cell proliferation following @entity2936 interaction without requirement of soluble factor. In contrast, modulation of Th1 differentiation resulted from @entity7938 - and @entity2937 -dependent interactions and from @entity688 production. The suppressive effects were mediated by @entity1075 (high)IgD+ @entity3053 (high) @entity11707 (high) @entity5893 (high) B cells and appeared to be indirect, through the induction of regulatory T cells as indicated by the appearance of @entity403 + @entity404 + @entity2902 +T cells. These data suggest that activation signals from T cells initiate regulatory properties in B cells that modulate T cell responses involving regulatory T cells. Finally, studies in autoimmune @entity1 revealed that regulation of T cell proliferation was defective in @entity1252 but efficient in other diseases. Restoration of efficient B-cell regulatory activity could provide innovative B-cell based treatment of @entity792 .
