Role of dopaminergic system(s) in mediation of the behavioural effects of XXXX .

@entity935 @entity1768 @entity35 @entity2955 @entity6138
To test the effects of @entity935 receptor blockade on @entity6138 (BN)-induced behavioural changes, adult male @entity35 were administered @entity1768 (0.01, 0.025, 0.1, 0.25 mg/kg, IP) followed 30 min later by BN (1 micrograms in 5 microliter) or saline (5 microliter) intracerebroventricularly (ICV). Subsequent behavioural effects were monitored in chambers equipped with strategically located infrared beam grids, controlled by a microprocessor. The following behaviours were monitored: locomotor activity (distance traversed), floor activity (horizontal or lateral displacement) and rearing activity (frequency of vertical displacement extending 17.8 cm above the floor). At all but the highest dose (0.25 mg/kg, which suppressed floor activity), @entity1768 failed to significantly alter any of the behavioural parameters monitored. Whereas at doses of 0.025 or lower, @entity1768 failed to alter BN-induced behavioural output, at doses of 0.1 mg/kg or greater, it significantly blocked the behavioural effects BN. In the next experiment, @entity935 neurons of adult male @entity35 were lesioned using @entity2955 ( @entity2955 ) (250 micrograms/10 microliter, ICV). The @entity2955 and sham-lesioned (control) @entity35 were administered BN (0.001, 0.01, 0.1 or 1.0 microgram, ICV) and their behaviour monitored. In the control animals, BN stimulated locomotor, floor and rearing activity in a dose-dependent manner. However, these behavioural effects of BN were markedly attenuated or absent in the @entity2955 -lesioned animals. These data further support our contention that centrally administered BN may mediate its behavioural effects, through the dopaminergic system(s).
