@entity12136 immunohistochemical expression in XXXX .

@entity1 @entity3852 @entity6461 @entity12136 @entity5 @entity1489 @entity957 @entity7390 @entity272 @entity1491
BACKGROUND: @entity12136 oncoprotein is a transcription factor known to regulate the expression of numerous genes important in extracellular matrix remodeling and angiogenesis. Up-regulation of @entity12136 has been shown to be important in a variety of @entity1 @entity5 and to correlate with prognosis. To our knowledge, this oncoprotein has not been examined in @entity1489 . DESIGN: A series of 26 primary cutaneous @entity272 with @entity1 records were independently examined for diagnosis confirmation and immunohistochemical expression by two dermatopathologists. The immunohistochemical expression for @entity12136 (Novocastra, Newcastle Upon Tyne, England, UK) was scored by an average of the mean labeling intensity (MLI), where no nuclear staining = 0, weak nuclear staining = 1, moderate nuclear staining = 2, and strong nuclear staining = 3. RESULTS: All @entity1491 ( @entity1491 ) and @entity3852 ( @entity3852 ) cases exhibited negative nuclear staining, for an average MLI of 0. @entity7390 , @entity957 in situ (SIS), and well-differentiated @entity957 ( @entity957 ) exhibited negative to weak nuclear staining, for an average MLI of 0.4 +/- 0.3. Moderately differentiated @entity957 exhibited moderate nuclear staining, for an average MLI of 1.8 +/- 0.6. Poorly differentiated @entity957 and metastatic @entity957 exhibited very strong nuclear staining, with an average MLI of 2.8 +/- 0.2. CONCLUSIONS: @entity12136 is not expressed in cutaneous @entity1491 or @entity3852 and is weakly expressed in SIS and forms of well-differentiated @entity6461 . Although the intensity of @entity12136 immunostaining distinguished between well-differentiated and poorly differentiated @entity6461 (p < 0.0001), it failed to discriminate between in situ and well-differentiated @entity957 . The preliminary data suggests @entity12136 may be important in the pathogenesis of invasive @entity6461 .
