Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the XXXX .

@entity16889 @entity836 @entity1641 @entity146 @entity935 @entity1510 @entity6884 @entity33479
@entity6884 in @entity1641 is a repetitive behavior pattern which may involve the activation of both narcotic receptors and @entity935 receptors in the CNS. @entity6884 frequency, determined in 7 nontreated @entity1641 under controlled conditions, was usually linear for many hours and ranged from 0.3 to 14.9 bites/min. Intravenous or IM injections of narcotic antagonists decreased these rates to almost zero by about 20 minutes after the injection was given. The duration of the response to a single injection ranged from 20 minutes for @entity1510 to 4 hours or more for @entity33479 and @entity16889 . Effective doses were 0.02 to 0.04 mg of @entity1510 /kg, 0.04 mg of @entity836 /kg, 0.08 mg of @entity33479 /kg, and 0.02 to 0.03 mg of @entity16889 /kg. @entity6884 could be prevented completely for up to a week by continuous infusion of 5 to 10 mg of @entity33479 /hr. @entity6884 resumed when the infusion was discontinued, and plasma @entity33479 concentrations decreased to below 5 ng/ml. Doses of @entity33479 as large as 0.4 mg/kg, IV, produced only minor side effects. These side effects included some passage of semifluid fecal material, intermittent penile relaxation, and mild sedation. Treated @entity1641 responded normally to external stimuli, retained their appetites, and performed appropriately when ridden. Sedation wore off during the course of prolonged infusions. Narcotic antagonists may provide a novel and effective treatment of @entity146 .
