Prognostic significance of increased bone marrow microcirculation in newly diagnosed XXXX : results of a prospective DCE-MRI study.

@entity1 @entity174 @entity2262 @entity149 @entity1582 @entity79 @entity35621
OBJECTIVES: Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in @entity1 with @entity1582 ( @entity1582 ). METHODS: We performed DCE-MRI of the lumbar spine in 131 @entity1 with newly diagnosed @entity1582 and analysed data according to the @entity35621 model to acquire amplitude A and exchange rate constant k ep. In 61 @entity1 a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify @entity174 . RESULTS: Correlation analysis revealed significant positive association between @entity2262 as well as immunoparesis with DCE-MRI parameters A and k ep. Additionally, A was negatively correlated with haemoglobin levels and k ep was positively correlated with LDH levels. Higher baseline k ep values were associated with decreased vertebral height in a second MRI (P   =   0.007) and A values were associated with new @entity174 in the lower lumbar spine (P   =   0.03 for L4). Pre-existing @entity79 or remission after therapy had no impact on the occurrence of @entity174 . Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival. CONCLUSION: DCE-MRI is a non-invasive tool with significance for @entity149 . KEY POINTS:     Qualitative parameters from DCE-MRI are correlated with established factors of disease activity     Increased marrow microcirculation might be a risk factor for @entity174     Amplitude A is an independent predictor for shortened overall survival.
