Brain activation patterns during video sexual stimulation following the administration of XXXX : results of a placebo-controlled study.

@entity1 @entity3826 @entity323
OBJECTIVES: To evaluate the in vivo effect of @entity3826 sublingual versus placebo on cortical and subcortical brain activation during video sexual stimulation. METHODS: Ten @entity1 with @entity323 and six potent controls underwent functional magnetic resonance of the brain during video sexual stimulation after the administration of either @entity3826 sublingual 4mg or placebo following a randomized, double blind design. Functional magnetic resonance sessions were performed with a 7-day interval. RESULTS: In potent controls, viewing erotic versus neutral films induced bilateral activations in a network of occipito-parietal and temporal inferior regions, in dorsolateral and premotor frontal cortex, in anterior temporal limbic areas and the thalamus, which were comparable to the @entity1 activations during erotic stimulation in the placebo condition. However, a striking difference was found in @entity1 , who demonstrated a significant and extended activation in the cingulate gyrus, frontal mesial and frontal basal cortex, bilaterally, in comparison with potent controls. These activated neural systems were modulated by @entity3826 administration which produced a picture that was similar to the one seen in potent controls. In @entity1 with spychogenic @entity323 @entity3826 sublingual caused an increase in the extension of the activated networks, plus additional activation foci in subcortical and deep structures, namely in the nucleus accumbens, hypothalamus and mesencephalon: this activation was greater than that seen with placebo. Interestingly, a down-regulation in the frontal basal and temporal limbic cortex was present as shown by a decrease of functional magnetic resonance imaging signal reflecting a deactivation of these regions. CONCLUSIONS: @entity3826 significantly enhances the activation of cortical and subcortical brain function during video sexual stimulation. @entity1 with @entity323 may have an underlying functional abnormality of the brain acting as a previously unrecognised aetiological factor.
