Patterns of failure in treatment of stage I and II diffuse XXXX .

@entity1 @entity66 @entity706 @entity5 @entity1600
Fifty-nine @entity1 with Stage I and II diffuse @entity706 were irradiated between 1966 and 1979. Seventeen had primary @entity1600 and 42 had extranodal presentations. Local recurrence was noted in 1 of 14 evaluable lymph node presentations and 8 of 36 extranodal distributions. Failures occurred in unirradiated lymph nodes (contiguous or transdiaphragmatic) in 3 of 17 @entity1 with @entity1600 and 6 of 42 with @entity66 . Dissemination occurred in 4 of 17 lymph node presentations and 6 of 42 extranodal @entity5 . Local recurrence was low, particularly among @entity5 . There was no identifiable dose effect for local control. Extension to contiguous or distant lymph nodes occurred in 15% of cases. The authors suggest that the transdiaphragmatic lymph nodes be included when treating @entity1 with @entity5 . The role of adjuvant chemotherapy remains unproved.
