The prevalence of cutaneous manifestations in @entity1723 @entity1 and their association with XXXX .

@entity1 @entity14654 @entity6 @entity2133 @entity27301 @entity2631 @entity1723 @entity2412 @entity5657
OBJECTIVE: The aim of our study was to evaluate the frequency of skin manifestations, including the @entity6 , in young @entity1723 @entity1 . In addition, we studied the relation of the cutaneous manifestations to @entity6 duration, glycemic control, and microvascular complications. RESEARCH DESIGN AND METHODS: The frequency of skin manifestations, including the @entity6 , were examined in 238 @entity1723 @entity1 (disease duration > 5 years) and 122 healthy control subjects in a cross-sectional study. In addition, we studied the relation of the cutaneous manifestations with @entity6 duration, glycemic control, BMI, microvascular complications, and stratum corneum hydration using a stepwise logistic regression. RESULTS: @entity6 skin manifestations were detected in 168 of 238 (71%) @entity1723 @entity1 and in 18 of 122 (14%) of the control subjects. Ichthyosiform skin changes of the shins, @entity2631 -like skin changes, @entity14654 , and @entity2133 were detected in 48 vs. 7%, 39 vs. 0%, 32 vs. 7%, and 21 vs. 0.8% of the @entity1 and control subjects, respectively. In the @entity6 @entity1 , a significant association was found between @entity5657 of the shins and @entity2631 -like skin changes of the hand (P < 0.001) and between @entity2631 -like skin changes and the skin dryness of the palms (P < 0.0001). When @entity6 risk factors were considered, @entity6 duration was significantly associated with @entity2631 -like skin changes and @entity5657 of the shins (P < 0.0001). The latter was also found to be related to @entity6 (P < 0.0001). @entity27301 was present in 21% of the @entity1 versus 9% in control subjects and was found to be exclusively associated with high BMI. CONCLUSIONS: Acquired @entity5657 is a common finding and the most prevalent skin manifestation in young @entity1723 @entity1 . The development of several skin manifestations in insulin-dependent @entity1 seems to be related to duration of @entity6 and to development of @entity2412 .
