Virus Type and Genomic Load in Acute XXXX : Severity and Treatment Response With Inhaled @entity1425 .

@entity1 @entity778 @entity5842 @entity697 @entity10201 @entity1425 @entity26 @entity5924 @entity325
BACKGROUND:    Acute @entity5924 frequently causes @entity1 hospitalization. Studies on different viruses or viral genomic load and disease severity or treatment effect have had conflicting results. We aimed to investigate whether the presence or concentration of individual or multiple viruses were associated with disease severity in @entity697 and to evaluate whether detected viruses modified the response to inhaled racemic @entity1425 . METHODS:    Nasopharyngeal aspirates were collected from 363 @entity1 with @entity697 in a randomized, controlled trial that compared inhaled racemic @entity1425 versus saline. Virus genome was identified and quantified by polymerase chain reaction analyses. Severity was assessed on the basis of the length of stay and the use of supportive care. RESULTS:    @entity10201 (83%) and @entity1 rhinovirus (34%) were most commonly detected. Seven other viruses were present in 8%-15% of the @entity1 . Two or more viruses (maximum, 7) were detected in 61% of the @entity1 . @entity778 was not associated with disease severity. A high genomic load of @entity10201 was associated with a longer length of stay and with an increased frequency of @entity26 and ventilatory support use. Treatment effect of inhaled @entity1425 was not modified by virus type, load or @entity325 . DISCUSSION:    In @entity1 hospitalized with @entity697 , disease severity was not associated with specific viruses or the total number of viruses detected. A high @entity5842 genomic load was associated with more-severe disease. CLINICAL TRIALS REGISTRATION:    NCT00817466 and EudraCT 2009-012667-34.
