The prognostic role of @entity2269 in XXXX .

@entity1 @entity1124 @entity5 @entity1711 @entity2269 @entity1970 @entity6175 @entity3 @entity136 @entity1349
UNASSIGNED: @entity1124 ( @entity1124 ) is characterized by an abundant @entity2269 . We examined the prognostic value of stroma density and activity in @entity1 with resectable @entity1124 treated with surgery and adjuvant @entity136 -based chemotherapy. FFPE-tissue from the pancreatectomy of 145 @entity1 was immunohistochemically stained for @entity6175 - @entity1711 and Masson's trichrome to assess stroma density, and @entity1970 ( @entity1970 ) expression for activated pancreatic stellate cells. Their expression was correlated with clinicopathological characteristics as well as @entity1349 ( @entity1349 ), progression-free survival (PFS), local progression-free survival (LPFS) and distant @entity3 free-survival (DMFS). After a mean follow-up of 20 months (range, 2-69 months), the median @entity1349 was 21 months and the 3-year @entity1349 was 35.7%. In multivariate analysis, highly-dense stroma was an independent prognostic parameter for @entity1349 (p = 0.001), PFS (p = 0.007), LPFS (p = 0.001) and DMFS (p = 0.002), while @entity1970 expression lacked significance. Interestingly, highly-dense stroma retained significance for the four clinical endpoints only in early (pT1-2) but not late (pT3-4) stage @entity5 . Additionally, late pT-stage (pT3-4), the presence of lymph node @entity3 (pN+ vs pN0), perineural/neural invasion and administration of adjuvant chemotherapy also correlated with prognosis in multivariate analysis. Altogether, stroma density constitutes an independent prognostic marker in @entity1124 @entity1 treated with adjuvant chemotherapy. Our findings highlight the dynamic complexity of desmoplasia and indicate that highly-dense stroma is correlated with better outcome. Further validation of the prognostic value of stroma as a biomarker and its role in @entity1124 @entity1 after adjuvant chemotherapy is warranted and will be performed in a prospective study.
