Maternal High-Fat Diet Causes a Sex-Dependent Increase in XXXX Expression and Cardiac Dysfunction in Adult Male @entity35 Offspring.

@entity11083 @entity63 @entity1283 @entity299 @entity11082 @entity65 @entity35 @entity11154 @entity1386
UNASSIGNED: Maternal high fat diet ( @entity1386 ) is associated with @entity65 later in life. This study tested the hypothesis that maternal @entity1386 causes programming of increased cardiac @entity11082 ( @entity11082 ) expression, resulting in heightened cardiac susceptibility to @entity63 in male offspring in a sex-dependent manner. Pregnant @entity35 were divided between control and @entity1386 ( @entity1386 ) groups. Maternal @entity1386 resulted in @entity1283 in only male offspring, but had no effect on cardiac systolic and diastolic function in both male and female offspring. In addition, maternal @entity1386 increased heart susceptibility to @entity63 -reperfusion injury in adult male offspring, but not female offspring. There was an increase in @entity11082 mRNA and protein abundance in male, but not female offspring. However, maternal @entity1386 had no effect on @entity11154 ( @entity11154 ) expression in both male and female offspring. @entity1386 resulted in decreased glucocorticoid receptors (GRs) binding to the glucocorticoid response elements (GREs) at the @entity11082 promoter, which was due to decreased GRs in the heart of adult male offspring. Inhibition of @entity11082 with @entity11083 abrogated maternal @entity1386 -induced increase in @entity299 vulnerability in male adult @entity35 . The results demonstrate that maternal @entity1386 causes programming of increased @entity11082 gene expression in the heart by downregulation of GR, contributing to the heightened cardiac vulnerability to @entity63 in adult male offspring in a sex-dependent manner.
