@entity3452 , @entity1255 and a family history of early XXXX .

@entity1 @entity414 @entity2002 @entity64 @entity1255 @entity63 @entity5784 @entity3452 @entity731 @entity385
BACKGROUND AND AIM: High plasma @entity3452 [ @entity3452 ] and @entity1255 ( @entity5784 ) levels are now considered to be independent risk factors for cerebro- and cardiovascular @entity731 , but little is known about the influence of @entity3452 and @entity5784 on the early events of @entity63 or their significance in subjects with a positive family history of @entity63 . The aim of this study was to evaluate the relationship between @entity5784 levels and the severity of @entity385 , and investigate whether there was a correlation between @entity3452 and @entity5784 levels in the @entity64 @entity1 and their @entity1 . METHODS: The study involved 35 @entity1 with early @entity385 aged 46.1 +/- 6.6 years and their 50 @entity1 aged 17.2 +/- 5.5 years. The @entity1 were grouped on the basis of the form of the @entity64 (transient, progressive or complete @entity64 ), and their levels of @entity3452 , @entity5784 , @entity414 (UA), @entity2002 ( @entity2002 ) and factor VII (FVII) activity were measured. RESULTS: @entity5784 and @entity3452 concentrations increased with the severity of the @entity63 , being highest in the @entity1 with complete @entity64 (15.1 +/- 2.9 mumol/L and 32.9 +/- 37.6 mg/dL respectively). A similar trend was found in the offspring, with the highest @entity5784 and @entity3452 values in the @entity1 of complete @entity64 @entity1 (12.6 +/- 4.4 mumol/L and 23.0 +/- 24.6 mg/dL). The control values were respectively 8.7 +/- 1.6 mumol/L and 5.35 +/- 7.05 mg/dL. The following correlations between the parents and @entity1 were noted: @entity3452 (r = 0.87 p < 0.0001), UA (r = 0.71 p < 0.001), @entity5784 (r = 0.45 p < 0.05), FVII (r = 0.45 p < 0.05), and @entity2002 (r = 0.42 p = 0.06). Correlations between @entity3452 and @entity5784 (r = 0.47 p < 0.05) and @entity2002 and FVII (r = 0.60 p < 0.01) were found in the @entity1 . Multiple regression analysis revealed that only @entity3452 and @entity2002 significantly influenced @entity5784 levels in the offspring with a positive family history. CONCLUSIONS: @entity5784 levels correlate with the severity of @entity385 and, in families with a history of @entity385 , the levels of the risk factors in @entity1 are determined by the levels in their parents.
