The effect of inhaled leukotriene D4 in XXXX .

@entity1 @entity748 @entity565 @entity15491 @entity57438 @entity2710
@entity15491 , (LTD4) is a potent bronchoconstrictor that may play an important role in @entity565 . To better characterize the effect of LTD4 on @entity1 airways, normal, rhinitic, and @entity748 subjects underwent inhalation challenge tests with LTD4 and @entity2710 . In all subjects increasing concentrations of LTD4 produced a parallel decrease in specific airway conductance and flow at 30% of vital capacity measured from a partial forced expiratory maneuver ( @entity57438 ). These changes occurred independent of any decrease in FEV1 or increase in functional residual capacity. The airway response to LTD4 was maximal within 2 to 3 min, persisted for approximately 30 min, and resolved over 1 to 3 h. Late effects were not seen. Rhinitic subjects were 3 to 5 times (p less than 0.01) and @entity748 subjects were 25 to 100 times (p less than 0.001) more sensitive than were normal subjects to LTD4. All 3 groups of subjects were 250 to 850 times more sensitive to LTD4 than to @entity2710 . Significant correlations were found between the concentration of LTD4 and the concentration of @entity2710 that produced a 35% decrease in specific airway conductance (r = 0.874; p less than 0.006) and a 30% decrease in @entity57438 (r = 0.751; p less than 0.04). These results confirm that LTD4 is a potent bronchoconstrictor in @entity1 , with a rapid onset of action and a prolonged effect. In contrast to previous reports, we found that LTD4 has an equal effect on both large and small airways and that both @entity748 and normal subjects have the same degree of increased sensitivity to LTD4 as to @entity2710 .
