XXXX deficiency is strongly related to @entity101 in early onset severe @entity1468 .

@entity1 @entity4149 @entity644 @entity101 @entity2232 @entity53 @entity1468 @entity6514 @entity842 @entity22487 @entity2431
OBJECTIVE: @entity22487 ( @entity6514 ) deficiency leading to @entity2431 has been related to @entity1468 ( @entity1468 ). Here we investigate whether @entity6514 is related to clinical profiles and vasoactive factors in early onset severe @entity1468 @entity1 . METHODS: 28 severe @entity1468 @entity1 and 20 uncomplicated normal pregnant @entity1 , with gestational weeks between 24 and 32weeks, were recruited. All cases and controls had singleton pregnancies and were matched for maternal age, parity, body mass index, and gestational weeks. Plasma levels of @entity6514 , @entity53 (E2), soluble Fms-like @entity4149 kinase-1 (sFLT-1), @entity2232 ( @entity2232 ), @entity842 (NO) were determined. RESULTS: @entity1468 @entity1 had significant lower @entity6514 [906(422-1768) vs. 2032(1400-2910)pg/mL, P=0.002], higher sFLT-1 [5.55(3.24-11.22) vs. 3.13(2.17-5.36)ng/mL, P=0.015] and higher NO [122.40(72.92-168.23) vs. 45.83(25.52-61.46) mol/L, P=0.0008] levels in their plasma than the controls. In the @entity1468 group, plasma @entity6514 level correlated negatively with systolic pressure (r=-0.48, P=0.012), diastolic pressure (r=-0.52, P=0.007) and mean arterial pressure (r=-0.54, P=0.005) even after controlling for maternal age; @entity6514 level did not correlate with @entity644 , plasma levels of E2, sFLT-1, @entity2232 or NO. In the control group, plasma @entity6514 level did not correlate with any of the above clinical profiles or laboratory measurements. CONCLUSIONS: @entity6514 levels were markedly lower in early onset severe @entity1468 and they correlated inversely with blood pressure only in @entity1 with @entity1468 . Although we cannot tell whether lower @entity6514 level is the causation or the result of @entity1468 , our study provides clinical evidences that @entity6514 deficiency is strongly related to @entity101 in early onset severe @entity1468 @entity1 .
