XXXX tolerance and plasma immunoreactive @entity2690 levels in acromegalics before and after selective transsphenoidal surgery.

@entity1 @entity6 @entity2690 @entity1218 @entity413
The @entity413 and immunoreactive @entity2690 (IRI) responses to a 100 g oral @entity413 tolerance test (oGTT) administered to 23 acromegalic @entity1 before and after transsphenoidal adenomectomy and to a sex and age-matched control group were studied. The preoperative growth hormone levels, ranging from 11 to 360 mU/l, had normalized (i.e. less than or equal to 5 mU/l) after surgery in all cases. Before surgery paradoxical increases in the GH level, either after i.v. @entity1218 injection or during the oGTT were seen in 14 @entity1 . After surgery, the paradoxical reaction to the oGTT had normalized in all cases and the increase measured after the @entity1218 injection normalized in nine out of 12 cases. The disturbed @entity413 tolerance (either @entity6 ) was cured by surgery. The plasma @entity413 levels determined 1 and 2 years after surgery did not differ from those found for the control group. Preoperative plasma IRI levels were significantly elevated, whereas after surgery the IRI levels had decreased. Fasting levels were normalized in all @entity1 . Two years after surgery, eight @entity1 still showed some abnormalities of the @entity2690 secretion (as revealed by the integrated sum and the maximum increment in IRI levels during the oGTT) despite the presence of normal circulating GH levels and a normalized paradoxical reaction to @entity1218 . The data show that after normalization of GH levels in acromegalics, increased @entity2690 secretion may still occur after @entity413 ingestion in some @entity1 . It is suggested that this abnormality could be the result of an increased pancreatic islet beta-cell mass, as a persisting abnormality of the acromegalic state, although peripheral @entity2690 resistance cannot be excluded totally.
