Detection of Endogenous @entity68 Reduction during Hepatocarcinogenesis at Susceptibility-Weighted MR Imaging: Value for Characterization of XXXX and Dysplastic Nodule in Cirrhotic Liver.

@entity1 @entity68 @entity5462 @entity409 @entity2286 @entity157 @entity9384
OBJECTIVE: To investigate the value of susceptibility-weighted imaging (SWI) for characterization of @entity157 ( @entity157 ) and @entity9384 ( @entity9384 ). MATERIALS AND METHODS: Sixty-eight cirrhotic @entity1 with 89 hepatocellular nodules underwent SWI. The radiological features of hepatocellular nodules on SWI were classified into three types: type A (iso- or hypointensity, and background @entity409 ), type B (hyperintensity, and background @entity409 ), or type C (hyperintensity, and no background @entity409 ). Intranodular and background liver @entity68 content was quantified and correlated with SWI pattern. Prussian blue staining was performed to quantify intranodular and background liver @entity68 content. RESULTS: Type A pattern (n = 12) contained 11 (91.7%) DNs and 1 (8.3%) @entity157 , Type B pattern (n = 66) comprised 1 (1.5%) @entity9384 and 65 (98.5%) @entity5462 (including 12 @entity9384 - @entity5462 and 53 overt @entity5462 ), and type C pattern (n = 11) was exclusively seen in @entity5462 . The @entity68 scores of @entity9384 - @entity5462 and overt @entity5462 were significantly lower than those of background livers [(0.091  0.30) VS (2.18  0.87), P = 0.000; (0.11  0.41) VS (2.16  0.97), P = 0.000; respectively]. There was no significant difference between @entity68 scores of DNs and those of background livers [(1.92  0.29) VS (2.17  039), P = 0.191]. For lesion-based and @entity1 -based analysis of @entity5462 ( @entity9384 - @entity5462 and overt @entity5462 ), type B pattern showed a sensitivity, specificity, accuracy, positive predicative value ( @entity2286 ), and negative predicative value (NPV) of 84.4% and 84.4%, 91.7% and 75%, 85.4% and 83.8%, 98.5% and 98.2%, 47.8% and 23.1%, respectively. CONCLUSION: SWI can provide valuable information for characterization of @entity157 and @entity9384 based on endogenous @entity68 reduction during hepatocarcinogenesis.
