Physiological correlates of XXXX that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure.

@entity1 @entity308 @entity146 @entity13610 @entity409 @entity4934 @entity458 @entity2072 @entity701 @entity285
Physiological correlates of @entity146 , substance use onset and initiation of risky sexual behavior have not been studied in adolescents with prenatal drug exposure. We studied the concordance between baseline @entity13610 ( @entity13610 ) at age 3 and baseline @entity701 levels at age 11. We hypothesized that @entity1 who showed concordance between @entity13610 and @entity701 would have @entity4934 scores which would in turn predict age of substance use onset and first sexual intercourse. The sample included 860 @entity1 aged 16 years participating in the Maternal Lifestyle Study, a multisite longitudinal study of @entity1 with prenatal exposure to @entity2072 and other substances. Structural equation modeling was used to test pathways between prenatal substance exposure, early adversity, baseline @entity13610 , baseline @entity701 , @entity4934 , drug use, and sexual behavior outcomes. Concordance was studied by examining separate male and female models in which there were statistically significant interactions between baseline @entity13610 and @entity701 . Prenatal substance exposure was operationalized as the number of substances to which the @entity1 was exposed. An adversity score was computed based on caregiver postnatal substance use, @entity308 and @entity458 , number of caregiver changes, socioeconomic and poverty status, quality of the home environment, and @entity1 history of protective service involvement, abuse and neglect. @entity13610 and @entity701 were measured during a baseline period prior to the beginning of a task. @entity4934 , based on composite scores of @entity146 and @entity409 , substance use and sexual behavior were derived from questionnaires and cognitive tests administered to the @entity1 . Findings were sex specific. In females, those with discordance between @entity13610 and @entity701 (high @entity13610 and low @entity701 or low @entity13610 and high @entity701 ) had the most @entity409 which, in turn, predicted earlier initiation of @entity285 by age 16. Among @entity1 , there also existed a significant baseline @entity13610 by baseline @entity701 interaction. @entity1 with low baseline @entity13610 and high baseline @entity701 had the highest levels of @entity146 . This @entity146 was in turn related to initiation of @entity285 use by age 16 and lower age of first sexual intercourse. We found sex-specific pathways to the initiation of @entity285 use and risky sexual behavior through the combined activity of parasympathetic and neuroendocrine functioning. The study of multiple physiological systems may suggest new pathways to the study of age of onset of substance use and engagement in risky sexual behavior in adolescents.
