Incidence, Predictors and Impact of Severe Periprocedural Bleeding According to VARC-2 Criteria on 1-Year Clinical Outcomes in XXXX After Transcatheter.

@entity1 @entity10747 @entity6 @entity548
UNASSIGNED: There are differences in reporting @entity548 complications after transcatheter aortic valve implantation (TAVI), which is a consequence of the lack of consensus for their definition. Furthermore, the amount of data on the impact of peri-procedural @entity548 on the mid-term prognosis is still limited. The aim of this study was to investigate the incidence, predictors, and impact of life-threatening and major bleedings as defined by the Valve Academic Research Consortium 2 (VARC-2) in @entity1 after TAVI over the mid-term prognosis.Consecutive @entity1 who underwent TAVI from March 2010 to December 2013 were included. All data were classified according to the VARC-2 criteria. We assessed the incidence and the predictors of @entity548 ( @entity548 ), defined as life-threatening/disabling (LT/D) or major @entity548 , and analyzed their impact on 30-day and 1-year clinical outcome.A total of 129 @entity1 were included (79.1    8.3 years; mean EuroSCORE = 17.8    12.7). The @entity548 occurred in 25 @entity1 (19.4%), of which 9 (7.0%) had LT/D and 16 (12.4%) had major @entity548 . @entity10747 ( @entity10747 ) access (OR 4.38, 95% CI 2.13-14.29, P = 0.01) and @entity6 (OR 2.93, 95% CI 1.08-7.93, P = 0.03) were identified as independent predictors of @entity548 . @entity1 with @entity548 had higher 30-day mortality (20.0% versus 4.0% P = 0.02) and 1-year mortality (40.0% versus 11.1%, P < 0.002). @entity548 independently predicted 1-year, all-cause mortality (HR 5.88, 95% CI 1.7319,94, P = 0.005). @entity548 are frequent after TAVI and are associated with decreased short and mid-term survival. @entity6 and @entity10747 access are independent risk factors for @entity548 .
