The health-related, social, and economic consequences of XXXX : a controlled national study.

@entity1 @entity7634 @entity304 @entity191
@entity191 ( @entity191 ) and atypical @entity304 (AP) cause a significant socioeconomic burden, but there is insufficient information about the total disease burden at a national level. Thus, the goal of this study was to estimate the excess direct and indirect costs of @entity191 and AP in a national sample. Using records from the Danish National @entity1 Registry (1997-2007), 13,400 @entity191 and 647 AP @entity1 were identified and compared with, respectively, 53,600 and 2,588 control cases randomly selected with respect to age, gender, civil status, and geographic location. Direct costs including frequencies of primary and sector contacts and procedures, and medication from primary and secondary sectors were obtained from the Danish Ministry of Health, the Danish Medicines Agency, and the National Health Security. Indirect costs, which included labor supply and social transfer payments, were based on income data derived from the Coherent Social Statistics. @entity1 with @entity191 and AP had significantly higher rates of health-related contact and medication use and a higher socioeconomic cost. Furthermore, they had very low employment rates, and those in employment had a lower income level than employed control subjects. The annual mean excess health-related cost was < @entity7634 >6,500 ( 8,975/  5,543) and < @entity7634 >9,771 ( 13,491/  8,332) for each @entity1 with @entity191 and AP, respectively. In addition, the @entity1 with @entity191 and AP received an annual mean excess social transfer income of < @entity7634 >324 (  276/ 447) and < @entity7634 >844 (  719/ 1,165), respectively. The employment- and health-related consequences could be identified up to 8 years before the first diagnosis and increased with disease advancement. @entity191 and AP have major socioeconomic consequences for @entity1 and society. The health effects are present for up to more than 8 years before a diagnosis of @entity191 /AP.
