[Expression of serum Clara cell secretory protein 10 in wheezing XXXX under 5 years old].

@entity1 @entity10974
OBJECTIVE: To study the expression of serum Clara cell secretory protein 10 ( @entity10974 ) and total IgE concentration in wheezing @entity1 under 5 years old. METHODS: Fifty-nine @entity1 with recurrent wheezing under 5 years old were classified into two groups: wheezing group 1 with atopic high risks (n=33) and wheezing group 2 without atopic high risks (n=26). Twenty-three @entity1 without infectious diseases served as a control group. Serum levels of @entity10974 and IgE were measured using a solid-phase sandwich ELISA. RESULTS: The serum levels of @entity10974 in wheezing group 1 (3.95    1.26 ng/mL) and wheezing group 2 (5.41    1.64 ng/mL) were significantly lower than those in the control group (8.72    2.23 ng/mL; P<0.01). The wheezing group 1 showed more decreased serum levels of @entity10974 compared with wheezing group 2 (P<0.05). The serum IgE levels in wheezing group 1 were significantly higher than those in wheezing group 2 and the control group (P<0.05). There were no significant differences in serum IgE levels between the wheezing group 2 and control group. There was a negative correlation between serum levels of @entity10974 and IgE in wheezing group 1 (r=-0.912, P < 0.01). CONCLUSIONS: Serum @entity10974 levels decrease remarkably in wheezing @entity1 , and more significant decrease is noted in @entity1 with atopic high risks. Serum @entity10974 levels are negatively correlated to serum IgE levels in @entity1 with atopic high risks.
