Personal and environmental characteristics related to @entity43 . II. Exposures to talcum powder, @entity286 , XXXX , and coffee.

@entity43 @entity1 @entity286 @entity5 @entity285
Vaginal exposures to talc and other particulates may play an etiologic role in @entity43 . Surgical sterilization may protect against @entity43 by blocking entry of such particulates into the peritoneal cavity. The authors assessed histories of talcum powder use, tubal sterilization, and hysterectomy with ovarian conservation in 188 @entity1 in the San Francisco Bay Area with epithelial @entity43 diagnosed in 1983-1985 and in 539 control @entity1 . To investigate the roles of blood-borne environmental exposures on @entity43 risk, they assessed lifetime consumption of coffee, @entity286 , and @entity285 in these @entity1 . Of the 539 controls, 280 were hospitalized @entity1 without @entity5 , and 259 were chosen from the general population by random digit telephone dialing. Ninety-seven (52%) of the @entity5 @entity1 habitually used talcum powder on the perineum, compared with 247 (46%) of the controls. Adjusted for parity, the relative risk (RR) = 1.40, p = 0.06. There were no statistically significant trends with increasing frequency or duration of talc use, and @entity1 did not differ from controls in use of talc on sanitary pads and/or contraceptive diaphragms. Fewer @entity43 @entity1 (7%) than controls (13%) reported prior fallopian tube ligation (RR, adjusted for parity, = 0.56, p = 0.06), and fewer @entity1 (20%) than controls (28%) reported prior hysterectomy (RR = 0.66, p = 0.05). The protective effect of hysterectomy was confined to those who underwent this surgery 10 or more years prior to interview and to those who had not undergone prior tubal sterilization. Consumption of cigarettes and @entity285 did not differ between cases and controls. By contrast, 11 (6%) cases never regularly consumed coffee, compared with 31 (11%) hospital controls and 26 (10%) population controls (RR, adjusted for smoking, = 2.2, p = 0.03, for the comparison using all controls). Overall, @entity43 risk among @entity1 who had drunk coffee for more than 40 years was 3.4 times that of @entity1 who had never regularly consumed coffee (p less than 0.01). However, the data exhibited no clear trends in risk with increasing consumption. Although risk ratios relating duration of coffee @entity43 were unaffected by adjustment for several characteristics, further study is needed to exclude potential confounding by other unmeasured characteristics.
