Comparative analysis of hemostatic agents in a XXXX model of lethal groin injury.

@entity1707 @entity548 @entity190 @entity520 @entity7586
BACKGROUND: Techniques for better @entity548 control after injury could change outcome. A large-animal model of lethal, uncontrolled @entity548 was developed to test whether the use of various hemostatic agents would decrease @entity548 and improve early survival. METHODS: A complex groin injury was created in 30 Yorkshire @entity1707 (42-55 kg) to produce uncontrolled @entity548 . This injury included semitransection of the proximal thigh and complete division of the femoral artery and vein. After 5 minutes, the animals were randomized to (n = 6 animals per group) @entity7586 ( @entity7586 ), standard dressing (SD), SD and Rapid Deployment Hemostat (RDH) bandage, SD and QuikClot hemostatic agent (QC), or SD and TraumaDEX (TDEX). Limited volume 0.9% saline (1,000 mL over 30 minutes) resuscitation was started 30 minutes after injury. We measured @entity190 , early mortality (180 minutes), and physiologic markers of @entity548 (e.g., cardiac output, blood pressure, hemoglobin, @entity520 ). RESULTS: Application of wound dressing decreased mortality in all groups compared with the @entity7586 group (83% mortality). However, this difference was significant (p < 0.05) only for the QuikClot hemostatic agent (0% mortality). Before the application of dressing (first 5 minutes), there were no differences in @entity190 between the groups. After application of dressings, the QC group had the lowest @entity190 (4.4 +/- 1.4 mL/kg). CONCLUSION: Of the hemostatic agents tested, QuikClot improved survival and decreased @entity548 in a @entity1707 model of lethal vascular and soft tissue injury.
