@entity715 risk factors and extent of XXXX in @entity3619 .

@entity1 @entity82 @entity1956 @entity5 @entity49 @entity7131 @entity3619 @entity1575 @entity715 @entity493
BACKGROUND AND AIMS: @entity715 of the small intrahepatic veins has been suggested to trigger liver tissue remodelling. We evaluated the prevalence of multiple @entity715 risk factors and their association with the extent of @entity82 in @entity3619 . METHODS: Ninety consecutive @entity1 with chronic @entity1956 or C without @entity5 , a history of @entity49 , or antiviral/immunosuppressive therapy within the last six months were included. Thrombophilic and coagulation factors were evaluated on the liver biopsy day. RESULTS: One or more @entity715 risk factors were found in 68% and > or =2 factors in 37% of @entity1 . Higher necroinflammatory activity was independently associated with higher prothrombin time (p=0.003), @entity493 aminotransferase level (p=0.011), and histological staging (p=0.018). @entity1 with staging scores of 4-6 compared with those with scores of 0-3 more frequently had @entity7131 (24% v 3%; p=0.007), antithrombin III (28% v 5%; p=0.005), and plasminogen (19% v 2%; p=0.03), and a trend for more frequent activated protein C resistance (8% v 0%; p=0.075). The presence of > or =1 significant @entity715 risk factor was observed in 11/25 (44%) @entity1 with staging scores of 4-6 and in 6/65 (9%) @entity1 with scores of 0-3 (p<0.001), being the only variable independently associated with advanced staging (odds ratio 2.4, p=0.02). CONCLUSIONS: @entity715 risk factors are frequently detected in @entity1 with @entity3619 and the presence of > or =1 significant factor is associated with more advanced @entity82 . Whether the association of such thrombophilic conditions with advanced @entity82 is a primary or secondary phenomenon and whether their development in combination with local inflammation accelerate the progression of @entity1575 need further evaluation.
