Photoacoustic tomography imaging and estimation of @entity26 saturation of hemoglobin in ocular tissue of XXXX .

@entity1 @entity5513 @entity2194 @entity63 @entity1347 @entity26 @entity16 @entity95 @entity519 @entity9734
UNASSIGNED: This study evaluated in  vivo imaging capabilities and safety of qualitative monitoring of @entity26 saturation of hemoglobin ( @entity9734 ) of @entity95 ciliary body tissues obtained with acoustic resolution (AR) photoacoustic tomography (PAT). @entity5513 was used to collect trans-scleral images from ciliary body vasculature of seven New Zealand White @entity95 . The PAT @entity9734 measurements were obtained under the following conditions: when systemic @entity9734 as measured by pulse oximetry was between 100% and 99% (level 1); systemic @entity9734 as measured by pulse oximetry was between 98% and 90% (level 2); and systemic @entity9734 as measured by pulse oximetry was less than 90% (level 3). Following imaging, histological analysis of ocular tissue was conducted to evaluate for possible structural damage caused by the @entity5513 imaging. @entity5513 was able to resolve anatomical structures of the anterior segment of the eye, viewed through the @entity1347 . Histological studies revealed no @entity16 . On average, @entity9734 values (%) obtained with @entity5513 were lower than @entity9734 values obtained with pulse oximetry (all p  <  0.001): 86.28      4.16 versus 99.25      0.28, 84.09      1.81 vs. 95.3      2.6, and 64.49      7.27 vs. 71.15      10.21 for levels 1, 2 and 3 respectively. @entity5513 imaging modality is capable of qualitative monitoring for deep tissue @entity9734 in @entity95 . Further studies are needed to validate and modify the @entity5513 modality specifically for use in @entity1 eyes. Having a safe, non-invasive method of in  vivo imaging of @entity9734 in the anterior segment is important to studies evaluating the role of oxidative damage, @entity519 and @entity63 in pathogenesis of @entity2194 .
