Effectiveness and safety of s-1-based therapy compared with XXXX -based therapy for advanced @entity14 : a meta-analysis.

@entity1 @entity390 @entity417 @entity882 @entity294 @entity1398 @entity14 @entity1487 @entity1210
Objectives. The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus @entity1487 -based therapy (FBT) for advanced @entity14 (ACRC). Methods. A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software. Results. A total of 1625 @entity1 from twelve RCTs including 820 @entity1 in the SBT group and 805 @entity1 in the FBT group were available for analysis. The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80-1.10), progression-free survival (HR = 1.03, 95% CI = 0.91-1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00-1.53) showed no statistical significance between SBT group and FBT group. The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 @entity1398 (OR = 0.49, 95% CI = 0.35-0.68) and @entity390 /vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 @entity417 , @entity882 , @entity1210 , @entity294 , and treatment-related deaths between two groups. Conclusions. SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for @entity1 of ACRC, but further investigations in different populations would be needed to confirm it.
