Beta-adrenergic stimulation of myocardial cyclic AMP in endotoxic XXXX .

@entity268 @entity308 @entity1425 @entity3044 @entity47211 @entity35 @entity2661 @entity1063 @entity413
Sympathetic nervous system activity and myocardial response to adrenergic stimulation were studied in the @entity35 during endotoxicosis. Plasma @entity413 concentration, adrenal @entity1063 (NE) and @entity1425 (E) content, spleen NE content, and myocardial NE and @entity268 content were analyzed in fed @entity35 given saline or endotoxin ( @entity47211 , 16.7 mg/kg). Values were determined at various times during a 6-hour period or at the agonal stage of shock. Myocardial @entity268 content was reduced by 1 hour, recovered at 4 hours, and was again @entity308 at the agonal stage. In addition, @entity3044 -stimulated @entity268 production in ventricular slices from ETOX @entity35 was attenuated by 3 hours after administration. These data suggest that myocardial beta-adrenergic receptor mechanisms are altered during endotoxicosis, which may account for reports of decreased functional responsiveness to @entity2661 under similar conditions. At 1 hour after ETOX, adrenal NE did not change, but E was depleted and remained low throughout the period. By 2 hours, spleen NE was also found depleted. Myocardial NE did not change until the agonal stage, when it was severely @entity308 . This implies that there may be nonuniform activation (duration and/or intensity) of sympathetic pathways during endotoxicosis.
