Correlation between expression levels of XXXX phosphorylase (dThdPase) and clinical features in @entity1 @entity356 .

@entity1 @entity5 @entity35343 @entity1014 @entity3 @entity356
BACKGROUND/AIMS: dThdPase ( @entity1014 phosphorylase) is an enzyme that is involved in @entity35343 metabolism. It has been recently reported that dThdPase is identical to platelet-derived endothelial cell growth factor. Previous studies demonstrated that the immunohistochemical expression of dThdPase was related with disease progression. The purpose of this study was to examine the expression levels of dThdPase and their prognostic significance in @entity356 , prospectively. METHODOLOGY: We obtained fresh samples ( @entity5 and adjacent normal mucosa) from 263 @entity1 with @entity356 who underwent gastrectomy between April 1998 and March 2000. dThdPase was analyzed by the enzyme-linked immunosorbent assay method. RESULTS: The expression levels of dThdPase in @entity5 (98.4 +/- 62.5 U/mg protein) was significantly higher than that in normal mucosa (46.5 +/- 27.8 U/mg protein) (P < 0.0001). Intratumoral dThdPase levels were significantly higher in Borrmann types II and III macroscopically (P < 0.01), in poorly differentiated type histologically (P < 0.05), and in the @entity5 -invading serosa (P < 0.001). The expression levels of dThdPase were also significantly higher in @entity5 tissue from @entity1 with lymph node @entity3 (P < 0.01) and in that from @entity1 with lymphatic invasion (P < 0.05). The survival rate of @entity1 with @entity5 of high dThdPase (> or = 100 U/mg protein) was significantly poorer than that of @entity1 with @entity5 of low dThdPase (< 100 U/mg protein) (P < 0.05). CONCLUSIONS: These findings indicate that the measurement of dThdPase may provide useful information for predicting prognosis in @entity356 .
