Clinico-pathological correlations in fatal XXXX . An immunohistochemical study of @entity1 brain penumbra.

@entity1 @entity64 @entity2806 @entity39 @entity7 @entity310 @entity3840 @entity842 @entity1495 @entity204 @entity385
@entity385 is one of the most frequent pathologies with high invalidating potential and a leading cause of @entity204 . The brain tissue adjacent to the central necrotic core, defined as penumbra, was extensively characterized mostly by imaging techniques and in animal models. Our goal was to identify a large panel of molecules in this particular area on @entity1 brains harvested at autopsy. Twenty-one @entity1 with @entity385 and seven control cases were taken into study. We used immunohistochemistry to characterize @entity39 . Metalloproteinases, mostly @entity1495 , seem to be involved in @entity2806 , but as a protective and not as a deleterious factor. Apoptotic molecules are not increasingly expressed in @entity64 compared to control cases. Mast cell enzymes chymase and tryptase are described for the first time in neurons and glia, even with unclear significance. Microglia appears active in @entity64 and stimulating methods directed to it could be useful. @entity842 synthases and @entity3840 were also involved in @entity64 cases but not in control ones. Other factors as @entity7 and its receptors, PDGF, b-FGF or @entity310 showed no significant expression related to @entity2806 . Animal study of penumbra and @entity1 tissue findings are distinct and research should be focused on the latter approach in order to find valuable and safe therapeutic methods.
