[Therapeutic Drug Monitoring of @entity1092 in XXXX :  A Prospective Study of The Effect of The Compliance and The Economic Level on the Trough Plasmatic Concentrations and @entity302 ].

@entity1 @entity137 @entity1092 @entity302 @entity6251
INTRODUCTION: @entity1092 (VA) is a widely used antiepileptic drug. Because of its pharmacokinetic variability and the influence of intrinsic and extrinsic factors such as the treatment compliance, VA therapeutic drug monitoring (TDM) is recommended in @entity1 . The aim of this study is to evaluate the effect of treatment compliance and the economic level on VA @entity6251 ( @entity6251 ) and @entity302 rhythm in @entity1 . MATERIAL AND METHODS: A one-year prospective study (August 2008-August 2009) concerning @entity1 (age  <= 5 years) regularly treated by VA who had a VA TDM. So, 276 plasmatic samples from 238 @entity1 were collected. The @entity1 were divided in two groups as following: the group 1 (G1) presenting a good compliance and a reliable questioning and the group 2 (G2) presenting a bad compliance and a non reliable questioning. We evaluated the interindividual variability by correlating the @entity6251 to the dose. Then, we divided the hole group in function of their economic levels (low-medium-high). RESULTS: Sex ratio male/female was 1.3. Median age was 5  years +/-3,9. The mean @entity6251 was 62   g/mL [0.12-131   g/mL]. VA @entity6251 were in the therapeutic range (TR) in 62%. @entity137 were noted in 4.2% of the @entity1 . G1 represented 70% of the @entity1 and G2, 30%. The @entity6251 were in the TR in 67% of G1 and 51% of G2 (p = 0.02). There was a significant difference between the @entity6251 in G1 and G2 (p = 0.02).There was no significative difference in the @entity6251 in function of the economic levels. There was no correlation between @entity6251 and the administered doses. The @entity302 were more spaced in @entity1 with therapeutic @entity6251 than those with @entity6251 in the TR (p = 0.002) and in G1than in G2 (p = 0.03). CONCLUSIONS: Compliance should be appropriate in order to optimize the TDM rule. A good compliance and a therapeutic @entity6251 allow a better control of @entity302 .
