Practice Patterns and Adverse Events of XXXX Sedation and Analgesia: A Report from the Pediatric Sedation Research Consortium.

@entity1 @entity3727 @entity391 @entity3810 @entity1363
OBJECTIVES: To describe practice patterns and adverse events associated with @entity3810 ( @entity3727 ) administration as the primary sedative outside the operating room in varied settings by a diverse range of providers, and to identify @entity1 and sedation characteristics associated with adverse events. STUDY DESIGN: Data prospectively collected by the Pediatric Sedation Research Consortium, which is comprised of 40 @entity1 's and general/community hospitals, was retrospectively analyzed for @entity1 who received @entity3727 as the primary sedative. Descriptive measures of @entity1 and sedation characteristics and adverse events were reported. A multivariable regression model was used to assess potential associations between @entity1 and sedation characteristics and adverse events. RESULTS: A total of 1634 @entity3727 administrations were identified. The majority was performed in sedation units, and most by advanced practice nurses or physician assistants. The most common adjunct medication was @entity1363 . There was a low prevalence of adverse events (6.5%), with @entity391 as the most common (2.4%) and only 3 (0.2%) serious adverse events reported. The odds of @entity391 increased when concomitant opioids were administered (OR 2.89, 95% CI 1.14, 7.32) and when nil per os (NPO) clear fluids <2  hours (OR 4.16, 95% CI 1.61, 10.76). NPO full meal <6  hours did not change the odds of @entity391 (OR 1.42, 95% CI 0.57, 3.57). There were no aspiration events. CONCLUSIONS: There was a very low prevalence of serious adverse events during @entity3727 administration in @entity1 outside of the operating room and by nonanesthesiologists. The odds of @entity391 increased when concomitant opioids were administered and NPO clear fluids <2  hours.
