The upregulation of angiotensin-converting enzyme during XXXX formation does not have functional consequences.

@entity1811 @entity1809 @entity1854 @entity934 @entity1617 @entity35 @entity1063 @entity4338 @entity8233
The aim of this study was to analyze if the upregulation of angiotensin-converting enzyme and @entity1809 receptors observed in a model of @entity8233 formation results in increased contractions to angiotensin I (AI) and AII. Endothelial denudation was performed in left common carotid arteries of 3-month-old male @entity35 . @entity35 were killed at days 0, 4, 8 and 14 after injury and vascular reactivity was assessed in an organ bath. Responses were always compared with their contralateral vessels as a control. Contractile responses to 75 mM @entity4338 were similar between groups. @entity1063 (0.1 microM) induced significantly higher contractions at days 0 and 4. Relaxation to @entity934 ( @entity1617 ) (1 nM to 0.1 mM) was suppressed at day 0 and increased with time after injury. Relaxations to @entity1854 (0.1 nM to 0.1 mM) were similar at all time points studied. Responses to AI and AII were increased at early steps of @entity8233 formation and decreased with time after injury correlating with increased responses to Ach. Concentration-response curves to AI and AII had similar EC50 or Emax values at the same time points. These results indicate that in the @entity35 i) @entity8233 formation does not impair contractile responses to @entity4338 nor relaxation to SNP, ii) a functional endothelium seems to regenerate with time after injury, and iii) the increase in @entity1811 activity and @entity1809 receptor number does not have functional consequences.
