Anatomical and functional brain abnormalities in unmedicated XXXX .

@entity1 @entity854 @entity308
BACKGROUND: Using magnetic resonance imaging (MRI) and resting-state functional magnetic resonance imaging (rsfMRI) to explore the mechanism of brain structure and function in unmedicated @entity1 with @entity308 ( @entity308 ). @entity1 AND METHODS: Fifty @entity1 with @entity308 and 50 matched healthy control @entity1 free of psychotropic medication underwent high-resolution structural and rsfMRI scanning. Optimized diffeomorphic anatomical registration through exponentiated lie algebra and the Data Processing Assistant for rsfMRI were used to find potential differences in gray-matter volume (GMV) and regional homogeneity (ReHo) between the two groups. A Pearson correlation model was used to analyze associations of morphometric and functional changes with clinical symptoms. RESULTS: Compared to healthy controls, @entity1 with @entity308 showed significant GMV increase in the left posterior cingulate gyrus and GMV decrease in the left lingual gyrus (P<0.001, uncorrected). In ReHo analysis, values were significantly increased in the left precuneus and decreased in the left putamen (P<0.001, uncorrected) in @entity1 with @entity308 compared to healthy controls. There was no overlap between anatomical and functional changes. Linear correlation suggested no significant correlation between mean GMV values within regions with @entity854 and ReHo values in regions with functional abnormality in the @entity1 group. These changes were not significantly correlated with symptom severity. CONCLUSION: Our study suggests a dissociation pattern of brain regions with anatomical and functional alterations in unmedicated @entity1 with @entity308 , especially with regard to GMV and ReHo.
