[Evaluation of XXXX administration in situations of suspected imminent @entity3152 : a retrospective cohort study in a tertiary centre].

@entity1 @entity3152 @entity228 @entity600 @entity288
PURPOSEThe administration of a single-course antenatal @entity228 treatment is recommended for pregnant @entity1 between 24 and 34 weeks with risk of @entity600 . The maximum effect is achieved when antenatal @entity288 are administered between 24h and 7 days before delivery. The objective of this study was to evaluate the occurrence of birth within seven days of @entity228 therapy in major obstetric situations with risk of preterm birthMETHODSRetrospective cohort study including 209 pregnant @entity1 hospitalized in risk of @entity3152 , submitted to @entity228 therapy for fetal lung maturation. The study was carried out between January 2012 and March 2014 at a university hospital. Main outcome measure was the number of @entity1 who delivered within 7 da ys after antenatal @entity228 administration. Two groups were defined according to the reason for starting @entity288 : threatened @entity3152 (Group APPT) and other indications for @entity228 therapy (Group RPPT). A Kaplan-Meier survival analysis was performed and a p value <0.05 was considered statistically significant.RESULTS46.4% (n=97) of pregnant @entity1 gave birth in the seven days following @entity228 administration. Delivery within 7 days occurred more frequently on group 2 in comparison to group 1 (57.3 versus42.4%; p=0.001). There is a statistically significant difference between the survival curve for groups 1 and 2, with a hazard ratio for delivery within 7 days 1.71 times higher for group 2 (95%CI 1.23-2.37; p<0.001)CONCLUSIONIt can be concluded that the probability of an event (birth within 7 days after @entity288 ) is smaller in the group of pregnant @entity1 admitted in the context of threatened @entity3152 than for other indications. The use of @entity288 in pregnant @entity1 admitted for suspected @entity3152 should be subject to rigorous clinical evaluation.
