Effects of XXXX on hormone secretion by @entity1 @entity977 in vitro.

@entity1 @entity268 @entity7704 @entity5 @entity10567 @entity5987 @entity1218 @entity11697 @entity977 @entity652 @entity864 @entity6192 @entity7410
Hormone release in culture in response to @entity10567 was examined in 28 @entity1 @entity977 : 10 null cell @entity652 , 4 gonadotropin-, 6 GH-, 6 ACTH-, and 2 PRL-producing @entity652 . The effects of @entity11697 were compared with those of the classical hypothalamic releasing hormones and other activators of intracellular signaling pathways. @entity11697 significantly stimulated GH release from 1 @entity5 (125 +/- 3% of control; P < 0.05) and ACTH release from 3 @entity5 (134 +/- 6%, 136 +/- 7%, and 137 +/- 9% of control; P < 0.05). The effects of @entity11697 were less potent than either @entity7704 on GH release in the @entity5 or @entity6192 on ACTH release in the @entity5 but similar to the responses seen with the @entity268 analog @entity5987 ( @entity7410 ). No detectable effects of @entity11697 on hormone release from null cell, gonadotropin-, or PRL-producing @entity652 were observed. Of the 5 somatotrope @entity5 that failed to respond to @entity11697 , all also failed to respond to either @entity7410 , @entity1218 , or @entity7704 . Of the @entity5 that failed to respond, 2 of the 3 also failed to respond to @entity6192 . In addition to eliciting hormone release appropriate to the @entity5 type, @entity11697 also stimulated glycoprotein hormone alpha-subunit (alpha SU) release from one @entity5 (229 +/- 35% of control, P < 0.01) and one @entity5 (149 +/- 4% of control; P < 0.01). This response was not mimicked by @entity7410 in the @entity5 , but in the @entity5 a significant alpha SU release was also seen after stimulation with the protein kinase C activator @entity864 and @entity7410 . These results suggest that the novel hypothalamic peptide @entity11697 has a modest role in the regulation of GH, ACTH, and alpha SU secretion from some @entity1 @entity5 pituitary corticotropes and somatotropes. Further studies are needed to elucidate the intracellular signaling pathways that mediate the effects of @entity10567 on hormone secretion by these @entity5 types.
