Thyroid hormones modulate the @entity137 of XXXX ( @entity1300 ).

@entity137 @entity353 @entity4336 @entity1324 @entity1955 @entity35 @entity1300 @entity5653 @entity1954
These experiments examine the role of @entity1955 (T4) and @entity1954 (T3) on the @entity137 of @entity1300 ( @entity1300 ). The first experiment is continuation of a study reported previously (Rozman et al., 1984). In this experiment, 60 male @entity35 were divided into 6 equal groups. Four groups of @entity35 were thyroidectomized by 3 mCi Na131 l/kg @entity35 . Five weeks later 2 of the thyroidectomized and 1 of the nonthyroidectomized groups of @entity35 received ip 100 micrograms @entity1300 /kg body weight in @entity4336 oil/ @entity1324 , whereas 3 corresponding groups of @entity35 served as vehicle controls. Two days after dosing and every 7 d thereafter, 1 thyroidectomized control group and 1 thyroidectomized @entity1300 -dosed group were given ip 105 micrograms T4/kg body weight. Mortality and body weight were monitored. The course of @entity1300 @entity137 was similar in nonthyroidectomized and thyroidectomized T4-treated @entity35 but was different in thyroidectomized animals without T4 replacement therapy. At d 90 after @entity1300 dosage, mortality was still lower and the mean time to death was increased (p less than 0.01) in this group of @entity35 compared to nonthyroidectomized or thyroidectomized T4-treated @entity35 . However, administration of T4 starting at d 91 after dosing with @entity1300 resulted within 2 wk in the same final mortality in thyroidectomized @entity35 as in nonthyroidectomized or thyroidectomized T4-treated animals, indicating that thyroid hormones modulate the time course of the @entity5653 but do not affect the ultimate mortality figure. Body @entity353 was much slower in thyroidectomized (approximately 1 g/d) than in nonthyroidectomized or thyroidectomized T4-treated @entity35 (approximately 8 g/d). In the second experiment the three vehicle control groups of the first experiment were used. Nonthyroidectomized vehicle controls and thyroidectomized T4-treated controls were maintained as before, whereas thyroidectomized controls received T3 at 5 micrograms/kg daily. One month later each @entity35 was dosed with @entity1300 at 100 micrograms/kg in @entity4336 oil/ @entity1324 . @entity137 of @entity1300 was similar in nonthyroidectomized, thyroidectomized T4-treated, and thyroidectomized T3-treated @entity35 as judged by mortality, body weight, and food intake, indicating no difference between T3 and T4 in the modulation of @entity1300 @entity137 .
