Involvement of Rho-kinase in collar-induced XXXX to @entity750 in @entity35 carotid.

@entity917 @entity8232 @entity12221 @entity1346 @entity56 @entity750 @entity1129 @entity35 @entity20757 @entity130
BACKGROUND: Vasoconstriction and vascular @entity56 to @entity750 has been described previously in animal models of @entity130 . The present study was undertaken to investigate the contribution of the @entity20757 /Rho-kinase pathway to the collar-induced the change of vascular contractility and reactivity in @entity35 carotid artery. METHODS: @entity35 Kyoto @entity35 were assigned to 4 treatments (n=12): vehicle, @entity8232 , @entity917 , and @entity8232 plus @entity917 . After 1 week of treatment, @entity130 was induced by positioning a @entity1346 collar around the right carotid artery for 1 week. Blood flow and vascular reactivity to @entity750 was determined 1 week after injury, and carotids were harvested for morphometry and biochemical analysis. RESULTS: @entity130 leaded to histological changes of vasoconstriction with the percent lumen patency of 54.5    4.3% (p<0.001) decreasing, accompanying by the reduction of the blood flow (2.79    0.22 ml/min vs. 3.67    0.26 mi/min/p<0.001) when compared to contralateral arteries. The increase of vascular reactivity sensitivity to @entity750 was observed in the collared artery when compared with the contralateral artery. Treatment with @entity917 and @entity8232 prevented the development of vasoconstriction, improved the carotid blood flow and normalized the @entity56 to @entity750 . Injury increased Angiotensin II type 1( @entity1129 (1)receptor, Rho-kinase, and p- @entity12221 (Thr696) expression. @entity917 lowered the Rho-kinase and p- @entity12221 (Thr696) expression. @entity8232 inhibited the p- @entity12221 (Thr696) expression. CONCLUSIONS: Collar-induced @entity130 resulted in the enhancement of vascular contractility and reactivity. The activation of @entity20757 /Rho-kinase signal pathway, stimulated by @entity1129 (1) receptor, plays an important role in the collar-induced the change of vascular contractility and reactivity.
