Clinicopathological analysis of factors related to XXXX perforation: influence of angiogenesis.

@entity1 @entity7 @entity5 @entity2279 @entity876 @entity14 @entity694
@entity14 perforation is a life-threatening complication of this disease. However, little is known about the anatomopathological factors or pathophysiologic mechanisms involved.Pathological and immunohistochemical analysis of factors related with tumoral neo-angiogenesis, which could influence @entity5 perforation are assessed in this study. A retrospective study of @entity1 with perforated @entity694 (Group P) and T4a nonperforated (controls) was conducted between 2001 and 2010. Histological variables (differentiation, vascular invasion, and location) and immunohistochemical ( @entity2279 , Growth Endothelial Vascular Factor ( @entity7 ) and @entity876 ) related with @entity5 angiogenesis were analyzed.Of 2189 @entity1 , 100 (4.56%) met the inclusion criteria. Of these, 49 @entity1 had nonperforated (2.23%) and 51 had perforated @entity5 (2.32%). The P group had lower number of right-sided @entity5 (7/51, 13.7%) compared with controls (13/49, 36.7%) (P=.01). The high-grade @entity5 (undifferentiated) represented only 3.9% of the perforated @entity5 ; the remaining 96.1% were well differentiated (P=.01). No differences between groups in the frequency of @entity876 mutation or @entity7 and @entity2279 expression were found. In the P group, only 2 (3.9%) had vascular invasion (P=.01). Of the 12 @entity5 with vascular invasion, only 2 were perforated (16.6%). The median number of metastatic lymph-nodes in P Group was 0 versus 3 in controls (Z=-4.2; P<.01).Pathological analysis of variables that indirectly measure the presence of @entity5 angiogenesis (differentiation, vascular invasion, and the number of metastatic lymph nodes) shows a relationship between this and the perforation, location, and @entity5 differentiation. We could not directly validate our hypothesis, by immunohistochemistry of @entity876 , @entity7 , and @entity2279 , that perforated @entity5 exhibit less angiogenesis.
