Effect of XXXX on aqueous humor flow, flare and intraocular pressure in eyes with glaucoma 2 years after trabeculectomy.

@entity1 @entity1538 @entity1138 @entity8814 @entity1139 @entity551
BACKGROUND: The purpose of this study was to determine the intraocular pressure (IOP), aqueous humor flow, flare and ocular side effects in eyes with a history of @entity8814 after trabeculectomy with adjunctive @entity1138 ( @entity1139 ). METHODS: Thirty-six eyes with primary or secondary @entity1538 and IOP < or = 8 mmHg during the postoperative period were studied 745 +/- 315 days after surgery. @entity1139 (0.2 or 0.5 mg/ml) was applied to the episclera with a cellular sponge. Flare was studied with the Kowa Laser Flare Meter 500. Aqueous humor flow was measured in the afternoon (Fluorotron Master II). IOP, visual fields and best corrected visual acuity were also examined. Twenty-two contralateral eyes without surgical intervention served as controls. RESULTS: The mean age of @entity1 was 44.5 +/- 16.8 years. The mean IOP was significantly lower in the @entity1139 group than in the control group: 9.6 +/- 6.4 mmHg vs 18.0 +/- 13.6 mmHg at 2 years (P < 0.001). Aqueous flow was significantly lower in subjects treated with @entity1139 than in controls (P < 0.001). The flare values were significantly higher in the @entity1139 -treated group, with a mean of 12.0 +/- 7.7 photon counts/ms, than in the control group, mean 7.9 +/- 4.6 photon counts/ms (P < 0.019). CONCLUSION: Our data suggest that @entity1139 is a useful @entity551 agent which seems to participate in a change in aqueous humor dynamics when applied topically as an aqueous solution.
