Angiogenesis after sintered bone implantation in XXXX parietal bone.

@entity692 @entity6667 @entity1810 @entity35
We studied the effect of bone substitutes on revascularization and the restart of blood supply after sintered bone implantation in comparison with synthetic @entity692 implantation and fresh autogenous bone transplantation (control) in @entity35 parietal bones. Methods for the study included the microvascular corrosion cast method and immunohistochemical techniques were also used. The revascularization of the control group was the same as that for usual wound healing in the observations of the microvascular corrosion casts. The sintered bone implantation group was quite similar to that of the control group. In the synthetic @entity692 group, immature newly-formed blood vessels existed even on the 21st day after implantation and the physiological process of angiogenesis was interrupted. Immunohistochemically, @entity6667 ( @entity6667 ), which activates angiogenesis, appeared at the early stages of both the control group and the sintered bone implantation group. @entity6667 reduced parallel with the appearance of the @entity1810 ( @entity1810 ), which obstructs angiogenesis, and the angiogenesis passed gradually into the mature stage. In the @entity692 implantation group, @entity1810 appeared at the early stage of the implants. The appearance of @entity6667 lagged and it existed around the pores of @entity692 even on the 21st day of the implantation. Proliferation and wandering of endothelial cells continued without any maturing of the vessels. These findings suggest that the structure and the components of the implant material affect angiogenesis after implantation as well as new bone formation.
