Electrocardiographic criteria for tricyclic antidepressant XXXX .

@entity1 @entity1445 @entity2974 @entity7129 @entity1370
To determine if electrocardiographic findings characterize tricyclic antidepressant ( @entity2974 ) @entity1445 and @entity1370 , 25 @entity1 suspected of taking an @entity1445 of @entity2974 were studied. Toxicologic assays for a @entity2974 were positive in 11 @entity1 (+ @entity2974 , n = 11). Toxicologic study results for a @entity2974 were negative in 14 @entity1 (- @entity2974 , control subjects). @entity1 with positive @entity2974 results (+ @entity2974 ) had a significantly greater heart rate (117 +/- 23 vs 100 +/- 22 beats/min, p less than 0.05), QRS duration (103 +/- 15 vs 87 +/- 10 ms, p less than 0.005) and corrected QT interval (449 +/- 38 vs 418 +/- 36 ms, p less than 0.05) than control @entity1 (- @entity2974 ) on admission. @entity1 with positive @entity2974 results also had a more rightward terminal 40-ms frontal plane QRS vector (195 +/- 51 degrees vs 54 +/- 64 degrees, p less than 0.001) than control @entity1 . This observation has not been previously reported. A terminal QRS vector of 130 degrees to 270 degrees accurately discriminated between - @entity2974 and + @entity2974 @entity1 (positive and negative predictive value = 1.00). Counterclockwise rotation (normalization) of the terminal frontal plane QRS vector was noted in + @entity2974 @entity1 during hospitalization. All + @entity2974 @entity1 had a @entity7129 , a corrected QT interval 418 ms or longer, and a terminal QRS vector between 130 degrees and 270 degrees. Using these values as selection criteria, a computer-aided search of 15,064 electrocardiograms (ECGs) recorded in our emergency department was performed. The likelihood of encountering such an electrocardiographic pattern in this population was 1.0%.(ABSTRACT TRUNCATED AT 250 WORDS)
