Impact of early surgery in the active phase on long-term outcomes in left-sided native XXXX .

@entity1 @entity204 @entity884
OBJECTIVE: We sought to evaluate the impact of early surgery in the active phase on long-term outcomes in @entity1 with left-sided native @entity884 . METHODS: Clinical data were retrospectively reviewed in 212 consecutive @entity1 with left-sided native @entity884 from 1990 to 2009. Early surgery in the active phase (within 2 weeks after the initial diagnosis) was performed in 73 @entity1 , and the conventional treatment strategy was applied in 139 @entity1 . In the conventional treatment group, 99 @entity1 underwent late surgical intervention. To minimize selection bias, propensity score was used to match @entity1 in the early operation and conventional treatment groups. Major adverse cardiac event was defined as a composite of @entity204 , repeat surgery, and recurrence of @entity884 during follow-up. RESULTS: The mean follow-up period was 5.5 years. In-hospital mortality was lower in the early operation group than in the conventional treatment group (5% vs 13%, P = .08). For 57 propensity score-matched pairs, the estimated actuarial 7-year survivals free from @entity204 and major adverse cardiac events were significantly higher in the early operation group than in the conventional treatment group ( @entity204 : 94%    5% vs 82%    5%, P = .011, major adverse cardiac events: 88%    5% vs 69%    7%, P = .006, respectively). CONCLUSIONS: Compared with conventional treatment, early surgery in the active phase was associated with better long-term outcomes in @entity1 with left-sided native @entity884 . Further prospective randomized studies with large study populations are necessary to evaluate more precisely the optimal timing of surgery in @entity1 with native @entity884 .
