@entity40864 Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in XXXX .

@entity1164 @entity1 @entity3656 @entity40864 @entity1165 @entity59871 @entity737 @entity2224 @entity1167 @entity71242 @entity1121
INTRODUCTION: The accurate prediction of the risk of @entity1164 ( @entity1164 ) in @entity1121 ( @entity1121 ) remains elusive. Corrected QT interval (QTc) duration is a known risk factor in various cardiac conditions. Single nucleotide polymorphisms (SNPs) have been linked to @entity3656 , and to @entity1164 . Here we investigated the role of 21 candidate SNPs in QTc duration and @entity1164 events in @entity1 with @entity1121 . METHODS AND RESULTS: This @entity1121 registry-based study included @entity1 with an ECG, medical history, first @entity1164 event data, and DNA available. Each individual SNP was assessed using logistic regression for associations with 2 outcomes: a prolonged QTc ( >= 440 milliseconds), and first @entity1164 event ( @entity1164 , resuscitated @entity1167 , and appropriate @entity737 ( @entity737 ) shock for @entity2224 / @entity1165 (VF/VT). In 272 @entity1121 @entity1 , there were 31 @entity1164 events (8 @entity1164 , 9 resuscitated @entity1167 , 14 @entity737 shocks for VF/VT; 11%). A QTc >=  500 milliseconds was associated with @entity1164 events on multivariate analysis (odds ratio [OR] = 4.0, 95% confidence interval [CI], 1.19-12.02, P = 0.016). In 228 Caucasian @entity1 , 2 SNPs in the @entity40864 gene ( @entity71242 and @entity59871 ) were associated with a prolonged QTc after correction for multiple testing. This remained significant after adjustment for current age, sex, and >= 1 @entity1164 risk factor (OR 1.59 per copy of the minor allele, 95% CI 1.08-2.39, P = 0.022, and OR 1.63, 95% CI 1.09-2.49, P = 0.020, respectively). No SNPs were directly associated with @entity1164 events. CONCLUSION: SNPs in the @entity40864 gene influence QTc interval duration but we have not demonstrated a direct association with the risk of @entity1164 .
