Excretion of @entity3150 from the skin of normal and XXXX @entity1 . Implications for @entity5068 balance studies.

@entity1 @entity9542 @entity753 @entity18749 @entity3150 @entity37793 @entity5068 @entity15104 @entity165 @entity9543
The 24 hr @entity5068 excretion from the entire skin surface was determined in six normal and five @entity753 (Type II) @entity1 fed a controlled, eucaloric diet containing 400 mg of plant @entity3150 . All subjects received radiolabeled @entity165 intravenously in order to measure @entity165 turnover and exchange. The 24 hr skin surface lipids were collected subsequently at intervals of 7-10 days. @entity3150 were quantified and identified by a combination of thin-layer and gas-liquid chromatographic methods. The mean 24 hr excretion of @entity165 in milligrams was 82.6 in the normal subjects and 82.7 in the @entity753 @entity1 . @entity165 constituted 89% of the total @entity5068 excretion through the skin surface in both groups. The specific radioactivity of @entity165 in the skin surface lipids increased gradually after the intravenous administration of the isotope. Within 4-5 wk the specific activity equaled and then remained higher than that of the plasma up to 10 wk. These specific activity curves suggested that, for at least some of skin surface @entity165 , there was a precursor-product relationship between the plasma @entity165 and the skin @entity165 . The presence of plant @entity3150 , @entity9542 , @entity9543 , and @entity15104 in the skin surface lipids of @entity1 has not been reported previously. We identified these @entity3150 in the skin surface lipids of all of our subjects. They constituted about 7% of the total skin surface @entity3150 . The occurrence of plant @entity3150 in the skin surface lipids suggested that plasma @entity3150 were transferred from the plasma into the skin. 1-2% of the skin surface @entity3150 were tentatively identified as @entity37793 and @entity18749 . The present study documented that a significant amount of @entity165 was excreted from the skin surface and that probably there was a net transfer of plasma @entity165 into the skin surface lipids. Both normal subjects and @entity753 @entity1 excreted similar amounts of @entity165 per day into the skin surface lipids. We suggest that this daily loss of @entity165 from the skin surface may need to be considered in @entity5068 balance studies.
