Antibody responses to XXXX and diphtheria vaccine in chronic and recurrent rhinosinusitis.

@entity1244 @entity1 @entity116
OBJECTIVES: Chronic rhinosinusitis may be accompanied by impaired immunity despite normal levels of serum immunoglobulins. Immune responses in @entity1244 @entity1 have previously been evaluated using polysaccharide vaccines. Our AIM was to assess the immune status by evaluating responses to diphtheria and @entity116 vaccine. METHODS: Specific antibodies were measured before and 2 weeks after vaccination in 25 @entity1 with chronic or recurrent @entity1244 and in 30 healthy individuals. The mean age of the @entity1 was 46 years and that of healthy controls 43 years. RESULTS: After vaccination the @entity1 had on average 4.08-fold lower responses to diphtheria toxoid and 2.20-fold lower responses to @entity116 than the controls. Fourteen out of 25 patients had antibody levels that did not reach the 95% normal distribution range of healthy controls after either diphtheria or @entity116 vaccination. All the @entity1 had normal levels of serum immunoglobulins. CONCLUSIONS: A significant proportion of @entity1 with persisting symptoms of rhinosinisitis may have impaired responses to protein vaccines. Responses to protein vaccines may be used to evaluate immune function of @entity1244 @entity1 .
