Recovery of thalamic @entity16 after Shiga toxin 2-associated XXXX .

@entity1 @entity75 @entity16 @entity2996 @entity51 @entity1381
INTRODUCTION: The underlying pathophysiology of @entity16 in @entity1 with @entity1381 ( @entity1381 ) remains unclear. It was recently attributed to a direct cytotoxic effect of Shiga toxin 2 (Stx2) in the thalamus. Conventional MRI of @entity1 with Stx2-caused @entity1381 revealed - despite severe @entity16 - only mild alterations if any, mostly in the thalamus. Against this background, we questioned: Does @entity2996 ( @entity2996 ) capture the thalamic damage better than conventional MRI? Are @entity16 and disease course better reflected by thalamic alterations as detected by @entity2996 ? Are other brain regions also affected? METHODS: Three @entity1 with serious @entity51 due to Stx2-associated @entity1381 were admitted to MRI/ @entity2996 at disease onset. Two of them were longitudinally examined. Fractional anisotropy (FA) and mean diffusivity were computed to assess Stx2-caused @entity16 . RESULTS: Compared to 90 healthy @entity1 , all three @entity1 had significantly reduced thalamic FA. Thalamic mean diffusivity was only reduced in two @entity1 . @entity2996 of the longitudinally examined @entity1 demonstrated slow normalization of thalamic FA, which was paralleled by clinical improvement. CONCLUSION: Whereas conventional MRI only shows slight alterations based on subjective evaluation, @entity2996 permits quantitative, objective, and longitudinal assessment of cytotoxic @entity75 in individual @entity1 .
