Exercise training restores the endothelial response to vascular growth factors in XXXX with stable @entity453 .

@entity1 @entity7 @entity409 @entity1307 @entity842 @entity453 @entity934
OBJECTIVE: Exercise training partially corrects @entity409 in @entity1 with @entity453 ( @entity453 ). Growth factors like @entity7 ( @entity7 ) as well as @entity1307 ( @entity1307 ) are known to modulate the bioavailability of @entity842 and, thereby, contribute to the maintenance of a normal vascular tone. The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in @entity1 with @entity453 . METHODS AND RESULTS: A total of 39 @entity1 were enrolled (training group: n   =   20; control group: n   =   19). At start of study and after 4 weeks, average peak flow velocity (APV) of the left internal mammary artery (LIMA) in response to @entity934 was measured invasively in the treatment and control groups. Serum concentrations of @entity7 and @entity1307 were determined by enzyme-linked immunosorbent assay. After exercise training, LIMA APV in response to @entity934 was increased by 93% (from 69        17% at start of study to 133        16% at 4 weeks, p   <   0.01 vs. start of study and control). At start of study, there was no association between any of the vascular growth factors and endothelial function. However, after exercise training a close correlation was apparent between the @entity934 -induced change in APV and @entity1307 (r   =   0.69, p   <   0.01) and @entity7 (r   =   0.76, p   <   0.01) serum concentrations. In the control group, these correlations were not evident and there was no change in endothelial function either. CONCLUSION: Exercise training improves agonist-mediated endothelium-dependent vasodilatation in @entity453 , partially through a restoration of the endothelial response to @entity1307 and @entity7 .
