Interplatform reproducibility of liver and XXXX measured with MR elastography.

@entity1 @entity4559 @entity409 @entity2693
PURPOSE: To assess interplatform reproducibility of @entity409 ( @entity409 ) and @entity4559 ( @entity4559 ) measured with magnetic resonance elastography (MRE) based on a 2D gradient echo (GRE) sequence. MATERIALS AND METHODS: This prospective Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved study involved 12 subjects (five healthy volunteers and seven @entity1 with @entity409 ). A multislice 2D-GRE-based MRE sequence was performed using two systems from different vendors (3.0T GE and 1.5T Siemens) on the same day. Two independent observers measured @entity409 and @entity4559 on confidence maps. Bland-Altman analysis (with coefficient of reproducibility, CR), coefficient of variability (CV), and intraclass correlation (ICC) were used to analyze interplatform, intra- and interobserver variability. @entity1 data were validated using a gelatin-based phantom. RESULTS: There was excellent reproducibility of phantom @entity2693 measurement (CV 4.4%). Mean @entity409 values were 3.44-3.48 kPa and 3.62-3.63 kPa, and mean @entity4559 values were 7.54-7.91 kPa and 8.40-8.85 kPa at 3.0T and 1.5T for observers 1 and 2, respectively. The mean CVs between platforms were 9.2%-11.5% and 13.1%-14.4% for @entity409 and @entity4559 , respectively, for observers 1 and 2. There was excellent interplatform reproducibility (ICC >0.88 and CR <36.2%) for both @entity409 and @entity4559 , and excellent intra- and interobserver reproducibility (intraobserver: ICC >0.99, CV <2.1%, CR <6.6%; interobserver: ICC >0.97, CV and CR <16%). CONCLUSION: This study demonstrates that 2D-GRE MRE provides platform- and observer-independent @entity409 and @entity4559 measurements. J. Magn. Reson. Imaging 2016;43:1064-1072.
