Alterations in the morphology of lamina cribrosa pores in XXXX .

@entity1 @entity3145 @entity16 @entity726 @entity735
AIMS: To determine alterations which occur in the size and shape of lamina cribrosa (LC) pores in @entity735 over a period of time. METHODS: Baseline and follow up optic disc photographs were retrospectively studied in 39 eyes of 39 @entity1 with @entity726 . Only eyes with a vertical cup to disc ratio equal to or greater than 0.6 were included in the study. In addition, all selected eyes had to have serial optic disc photographs obtained at least 3 years apart allowing clear visualisation of LC surface. The association of the alterations in LC surface morphology with @entity1 specific and eye specific characteristics was statistically analysed. RESULTS: During a mean study period of 3.90 (SD 0.7) years, individual pore size (mean pore area to disc area ratio) exhibited a significant decrease between baseline and follow up measurements of each eye (p<0.0001). However, during the study period, total pore area to disc area ratio did not change (p>0.05), and the change in pore shape in some eyes (from circular to more oval and elongated) was statistically insignificant (p = 0.12). Although a relation was detectable between the optic disc and lamina cribrosa parameters at a given time, which reflects cumulative effects, during the study period, there was no significant association between the changes of the LC parameters and @entity3145 . The rate and the magnitude of the changes in individual pore size during the study period were not significantly different among the eyes exhibiting progressive @entity16 and those staying stable (p>0.05). CONCLUSION: These findings demonstrate that the LC surface morphology exhibits changes along with the glaucomatous @entity16 . However, the clinical appearance of LC surface in @entity735 may continue to change, even when the @entity16 is clinically stable. These findings are probably associated with the chronic cellular events of tissue remodelling that occur in the glaucomatous optic nerve head.
