Ghrelin for XXXX .

@entity1 @entity712 @entity5 @entity3085 @entity2124 @entity1030 @entity454
Ghrelin, a natural ligand for the @entity2124 ( @entity2124 )-secretagogue receptor, is primarily produced in the stomach. Administration of ghrelin stimulates food intake and @entity2124 secretion in both animals and @entity1 . Ghrelin is the only circulating hormone known to stimulate appetite in @entity1 . As @entity2124 is an anabolic hormone, protein stores are spared at the expense of fat during conditions of caloric restriction. Ghrelin also inhibits the production of anorectic proinflammatory cytokines. Thus, ghrelin exhibits anti-cachectic actions via both @entity2124 -dependent and -independent mechanisms. Several studies are evaluating the efficacy of ghrelin in the treatment of @entity3085 caused by a variety of diseases, including @entity712 , @entity1030 , @entity5 , and @entity454 . These studies will hopefully lead to the development of novel clinical applications for ghrelin in the future. These studies have also facilitated a better understanding of the molecular basis of the anti-catabolic effects of ghrelin. This review summarizes the recent advances in this area of research.
