A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed XXXX /AIDS.

@entity1 @entity404 @entity645
We conducted a cross-sectional study to determine the prevalence and risk factors of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed @entity645 /AIDS. One thousand nine hundred and forty-eight newly diagnosed @entity645 -infected @entity1 were enrolled between 2009 and 2010. Serum samples obtained from each individual were collected for complete blood count. Factors associated with the presence of leukopenia and thrombocytopenia were analyzed by multiple logistic regression. The overall prevalence of leukopenia and of thrombocytopenia was 33.2% and 15.6%, respectively. The prevalence of leukopenia was higher among females than among males (39.4% versus 31.2%). The prevalence of leukopenia increased with decreasing @entity404 count (8.2%, 26.5%, 33.4%, and 41.5% among @entity1 with @entity404 count of >=  350, 200-349, 50-199, and < 50 cells/mm3 respectively). The prevalence of thrombocytopenia also showed an increasing trend with decreasing @entity404 count (5.8%, 12.2%, 17.8%, and 17.5% among @entity1 with @entity404 count of >=  350, 200-349, 50-199, and < 50 cells/mm3, respectively). Logistic analysis showed that female sex, lower @entity404 count, and Han ethnicity were significantly associated with an increased risk of leukopenia, and that lower @entity404 count, and @entity645 transmission by blood were significantly associated with an increased risk of thrombocytopenia. The study reflects that leukopenia and thrombocytopenia are common among Chinese adults with newly diagnosed @entity645 /AIDS; and lower @entity404 count is associated with an increased risk of both leukopenia and thrombocytopenia. We propose that a routine assessment of these parameters is necessary for timely and adequate clinical management.
