Radioxenon washout for evaluation of vasodilator therapy in XXXX .

@entity63 @entity235 @entity3124 @entity3302 @entity5327
@entity5327 follows a @entity3124 in blood flow to the intestine. Absence of a practical diagnostic test results in delayed diagnosis and inability to evaluate changes in blood flow due to vasodilator therapy. We recorded the disappearance of radioxenon (133Xe) from @entity63 bowel to quantitate the decreased perfusion and to assess changes in submucosal blood flow after intra-arterial @entity3302 . The @entity63 colon, its only blood supply from collaterals, was formed into a Thirty-Vella loop. An infusion catheter placed at the origin of the superior mesenteric artery (SMA) was used to deliver saline or @entity3302 (0.1 mg./kg./min). Eleven control @entity235 received N.S. only. In nine @entity235 @entity3302 infusion was started immediately and in another 12 @entity235 two hours after the production of @entity63 . Submucosal blood flow was determined by the per cent washout at two minutes of an 0.05 ml. injection of 133Xe dissolved in N.S., made into the submucosal space of the colostomy.
