Increased Plasma Concentrations of Midregional Proatrial Natriuretic Peptide Is Associated With Risk of Cardiorenal Dysfunction in Type 1 XXXX .

@entity1 @entity8 @entity6 @entity1009 @entity1372 @entity633 @entity989 @entity5433 @entity65 @entity165 @entity454
BACKGROUND: To examine possible associations between midregional proatrial natriuretic peptide (MR-proANP) and @entity6 complications at baseline and risk of mortality and @entity454 ( @entity454 ) during follow-up in type 1 @entity6 . METHODS: Observational study including 667 @entity1 , with plasma MR-proANP measured at baseline. Complications were defined as micro- (n = 168) or macroalbuminuria (n = 190) (urinary albumin excretion rate (UAER) 30-299 or >= 300mg/24h), previous @entity65 ( @entity65 ) (n = 143), cardiac @entity5433 (heart rate variability < 11 beats/min) (n = 369), and @entity989 (n = 523). Adjustments included gender, age, systolic blood pressure, estimated glomerular filtration rate (eGFR), UAER, HbA1c, total @entity165 , 24-hour urinary @entity1372 excretion (24h-UNa), body mass index, daily insulin dose, antihypertensive treatment, and smoking in linear regression analyses and analysis of covariance models. Development of @entity454 (dialysis, renal transplantation, or GFR/eGFR < 15ml/ @entity1009 .73 m(2)) and mortality was recorded through national registers. RESULTS: The cohort included 293 (44%) females, aged 55    13 years. Plasma MR-proANP (median (interquartile)) was 74.7 (49.2-116.8) pmol/L. Adjusted, MR-proANP correlated positively with age and UAER and negatively with eGFR, 24h-UNa, total @entity165 , and HbA1c (P < 0.05). Moreover, MR-proANP levels increased with @entity633 degree and were higher in @entity1 with previous @entity65 (P  <= 0.001), but similar in @entity1 with or without @entity5433 or @entity989 (P >=  0.076). During follow-up (3.5 (3.1-4.0) years), higher MR-proANP concentrations predicted @entity454 and mortality combined (n = 35) adjusted for gender, age, systolic blood pressure, eGFR, and previous @entity65 (hazard ratio per 1SD increase in logANP: 2.8 (1.6-4.7; P < 0.001)). CONCLUSIONS: Increased plasma MR-proANP was associated with @entity8 , increased @entity633 , and previous @entity65 . Moreover, MR-proANP concentrations were associated with increased risk of development of @entity454 and mortality combined during follow-up.
