Paraneoplastic autoimmune @entity7995 with @entity2479 defined by XXXX -IgG.

@entity1 @entity1018 @entity227 @entity6113 @entity404 @entity4153 @entity2479 @entity1652 @entity5 @entity2 @entity21969 @entity7995 @entity24739 @entity989 @entity151 @entity405 @entity703
Autoantibodies have defined two paraneoplastic @entity227 related to @entity151 : @entity989 ("CAR"-IgG [23kDa, @entity24739 ]) and @entity7995 collapsin response-mediated protein 5 ( @entity21969 -IgG [62kDa]). Among 16 @entity1 with @entity21969 -IgG and @entity7995 (aged 52-74 years; all smokers, 9 @entity1 ), we documented coexisting @entity2479 in 5. None had CAR-IgG. Fifteen had subacute @entity1018 , swollen optic discs, and field defects. Vascular leakage was evident at and remote from the disc; 5/5 tested had abnormal electroretinograms. Nine had striking vitreous cells. Vitrectomy showed @entity6113 (4/4), predominantly @entity404 (+) (1/1). Most @entity1 had multifocal neurological accompaniments. Cerebrospinal fluid contained lymphocytes (7-32), elevated protein, multiple oligoclonal immunoglobulin bands, and @entity21969 -IgG. Three @entity1 superficially resembled @entity1652 at presentation. One autopsied @entity1 had predominantly @entity405 (+) T lymphocytes infiltrating optic nerve and spinal cord. Eleven @entity1 had confirmed @entity4153 ; 1 had imaging evidence of @entity2 ; 3 had @entity703 . Full-length @entity21969 protein was identified in normal retina and optic nerve by Western blot analyses. Photoreceptor cells, retinal ganglion cells, and nerve fibers exhibited @entity21969 -specific immunoreactivity. In summary, @entity21969 -IgG defines a paraneoplastic ophthalmological entity of combined @entity7995 and @entity2479 with vitreous inflammatory cells. Positive serology obviates the need for vitreous biopsy and expedites the search for @entity5 .
