Information processing deficits in acutely @entity716 @entity161 XXXX medicated and unmedicated at the time of admission.

@entity1 @entity161 @entity716 @entity427 @entity734
OBJECTIVE: In @entity1 with @entity161 , information processing deficits, such as those reported in studies that measured prepulse inhibition of the @entity1 @entity427 response and @entity734 of @entity427 magnitude, may be improved with atypical antipsychotic treatment. However, it remains unclear whether antipsychotic medication is directly responsible for the improvement or whether differences in prepulse inhibition reflect other factors, such as acuity status. The present study investigated the effects of antipsychotics on prepulse inhibition and @entity427 in acutely hospitalized @entity1 with @entity161 . METHOD: Forty-one acutely @entity716 @entity161 @entity1 (21 who were unmedicated at the time of admission and 20 who had been receiving antipsychotic treatment) were tested within 72 hours of hospital admission. Thirteen healthy subjects were also studied for comparative purposes. Primary dependent measures were @entity427 responsivity, reactivity, prepulse inhibition, and @entity427 . RESULTS: @entity161 @entity1 , whether medicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subjects and did not statistically differ from each other in @entity427 magnitude, prepulse inhibition, or @entity734 . There was a higher number of @entity427 "nonresponders" among those who had been receiving medication versus those unmedicated at the time of admission. CONCLUSIONS: The present findings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when @entity161 @entity1 are acutely symptomatic. These results suggest that the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during acute @entity716 states while the @entity1 are in early phases of medication treatment.
