Correlation between Ki67 and Histological Grade in XXXX @entity1 Treated with Preoperative Chemotherapy.

@entity1 @entity1782 @entity0 @entity7273 @entity5 @entity513 @entity549 @entity1722
BACKGROUND AND AIM: @entity0 ( @entity0 ) is a heterogeneous disease and cell proliferation markers may help to identify subtypes of clinical interest. We here analyzed the correlation between cell proliferation determined by Ki67 and HG in @entity0 @entity1 undergoing preoperative chemotherapy (PCT). MATERIALS AND METHODS: We obtained clinical/pathological data from @entity1 with invasive @entity0 treated at our institution from 1999 until 2012. Expression of @entity1782 ( @entity1782 ), @entity7273 ( @entity7273 ), epidermal growth factor receptor type 2 ( @entity1722 ) and Ki67 were determined by immuno-histochemistry (IHC). Clinicopathological subtypes were defined as: Luminal A, @entity1782 and/or @entity7273 positive, @entity1722 negative, HG 1 or 2; Luminal B, @entity1782 and/or @entity7273 positive, @entity1722 negative or positive and/or HG 3; @entity549 ( @entity549 ), @entity1782 , @entity7273 and @entity1722 negative independent of HG; @entity1722 positive, @entity1782 , @entity7273 negative and @entity1722 positive, independent of HG. By using Ki67, a value of 14% separated Luminal A and B @entity5 , independently of the histological grade. We analyzed correlations between Ki67 and HG, to define @entity0 subtypes and their predictive value for response to PCT. RESULTS: 1,560 @entity0 @entity1 were treated in the period, 147 receiving PCT (9.5%). Some 57 had sufficient clinicopathological information to be included in the study. Median age was 52 years (26-72), with 87.7% invasive @entity513 (n=50). We performed IHC for Ki67 in 40 core biopsies and 50 surgical biopsies, 37 paired samples with Ki67 before and after chemotherapy being available. There was no significant correlation between Ki67 and HG (p=0.237), both categorizing @entity1 into different subtypes. In most cases Ki67 decreased after PCT (65.8%). Only 3 @entity1 had pathologic complete response (cPR). CONCLUSIONS: In our experience we did not find associations between Ki67 and HG. Determination of clinicopathological luminal subtypes differs by using Ki67 or HG.
