@entity5128 selectively stimulates secretion from noradrenergic XXXX chromaffin cells.

@entity1041 @entity11040 @entity5128 @entity1425 @entity1022 @entity973 @entity5217 @entity7832 @entity11243 @entity2922 @entity594 @entity141 @entity1063 @entity291
1. The effects of @entity5128 ( @entity1041 ) on @entity2922 secretion from primary cultures of @entity1063 -rich (noradrenergic) and @entity1425 -rich (adrenergic) @entity291 chromaffin cells were studied. @entity1041 stimulated @entity2922 secretion from both cell types but was a much more effective secretory stimulus for noradrenergic cells. 2. @entity1041 -induced @entity2922 secretion was dependent on extracellular @entity141 , was partially inhibited by @entity594 and by @entity1022 , and was potentiated by @entity7832 . Other K+ channel blocking agents including @entity973 , @entity5217 , and @entity11243 did not stimulate @entity2922 secretion. 3. @entity1041 had no effect on @entity141 -induced secretion from @entity11040 -permeabilized chromaffin cells. 4. @entity1041 presumably evokes secretion by inhibiting K+ channels, depolarizing chromaffin cells, and activating voltage-gated @entity141 channels in the cells. Noradrenergic cells appear to be more sensitive to K+ channel inhibition than are adrenergic cells. 5. The secretory response of the chromaffin cells to @entity1041 increased with time in culture. 6. In addition to being a more effective secretagogue in noradrenergic cells, @entity1041 was also more effective in stimulating @entity2922 synthesis in these cells.
