Investigating the Effect of a Single Infusion of Reconstituted High-Density Lipoprotein in XXXX with Symptomatic Carotid Plaques.

@entity1 @entity650 @entity66 @entity2842 @entity1495 @entity65 @entity165
BACKGROUND: Elevation of plasma high-density lipoprotein (HDL) @entity165 concentration reduces cardiovascular mortality and morbidity. HDLs have been shown to possess acute anti-inflammatory, antioxidant, and antithrombotic properties. We hypothesize that HDL therapy can acutely alter local and systemic manifestations of plaque instability. METHODS: Forty @entity1 with early symptomatic @entity66 were randomized to either receive reconstituted HDL (rHDL) 40  mg/kg (n  =  20) or placebo (n  =  20). Carotid endarterectomies were performed 24  hr later. Plaques were obtained intraoperatively and used for  measurement of thrombomodulatory genes expression. Plasma samples were collected before the infusion, 24 and 48  hr later to measure changes in systemic markers of plaque instability. RESULTS: No significant differences were noted in thrombomodulatory genes expression between the 2 groups. Systemic levels of tissue factor, @entity1495 ( @entity1495 ), and monocyte chemotactic factor-1 ( @entity2842 ) were significantly reduced in the rHDL group. However, the effects on @entity1495 and @entity2842 were abolished in the immediate postoperative period. Although rHDL did not affect plasma @entity650 levels 24  hr following the infusion, it prevented the significant postoperative elevation seen in the placebo group. CONCLUSIONS: A single infusion of rHDL can acutely alter plasma biomarkers associated with plaque instability and @entity65 .
