Unfavourable clinicopathologic features and low response rate to systemic adjuvant therapy: results with regard to poor survival in young Chinese @entity0 XXXX .

@entity1 @entity0 @entity3012 @entity5 @entity4434 @entity3 @entity204 @entity1722
The prognostic factors of young @entity0 @entity1 (BCPs) are still controversial. This study is aimed at evaluating the prognosis of young BCPs by characteristics and treatment response. We analysed the data on 2,593 operable BCPs age <or=50 years who were treated in the @entity5 Hospital of Fudan University, Shanghai, China between 1990 and 2004. The overall survival and recurrence/ @entity3 -free survival were compared. In the study, 782 @entity1 (30.2%) were <or=40 years, and 1,811 (69.8%) were 41-50 years old at their primary diagnosis. BCPs <or=40 years presented more unfavourable features than the 41-50 years BCPs (P < 0.05). They were more likely to experience @entity204 (P < 0.001) and recurrence/ @entity3 events (P < 0.001) even when they underwent the same adjuvant therapy in parallel with their counterparts (P < 0.05). In a multivariate analysis, age was an independent predictive factor for @entity4434 (HR = 0.26, 95% CI = 0.44-0.89, P = 0.009) but not for @entity3012 (P > 0.05). Higher TNM stage and chemotherapy, but not @entity1722 over-expression, were predictive factors for young Chinese BCPs. The characteristics of @entity0 are more aggressive in young Chinese BCPs. Their prognostic factors are obviously different from those of the elder group. Current therapy was not as effective for them.
