XXXX in childhood.

@entity1 @entity6766 @entity565 @entity1097 @entity74 @entity484
BACKGROUND: The term @entity74 is an early attempt to define specific endotypes of @entity1 with @entity565 , @entity484 , or both and increased IgE levels. OBJECTIVE: We performed a longitudinal analysis of the relevance of the @entity1097 endotype from birth to age 13  years. METHODS: Allergic sensitization against 28 @entity6766 was assessed at   , 1  , 4, 6, and 13 years of age in 399 @entity1 from the Copenhagen Prospective Study on @entity565 in Childhood2000 birth cohort by using both skin prick test responses and specific IgE levels. @entity565 and @entity484 were diagnosed longitudinally by strictly adhering to predefined algorithms. Associations between allergic sensitization, @entity565 , and @entity484 were estimated by means of logistic regression, and a machine learning approach was used to identify temporal phenotype clusters of these traits. RESULTS: Allergic sensitization showed no association with @entity565 through early childhood (0-6  years) when analyzed as any sensitization (odds ratio [OR] range, 0.78-1.29; P  >=   .48). However, at 13  years of age, any sensitization was associated with @entity565 (OR range, 4.02-5.94; all P  <  .001). In contrast, any sensitization was associated with @entity484 at   , 1  , and 6  years of age (OR range, 2.06-6.02; P   <=  .01) and borderline associated at 4  years of age (OR, 1.61 [95% CI, 0.96-2.69]; P  =  .07) but not at 13  years of age (OR, 1.57 [95% CI, 0.78-3.16]; P  =  .21). We identified 4 latent patterns of disease development that were either dominated by sensitization (37%), @entity484 (26%), @entity565 (14%), or healthy status (24%). CONCLUSION: We found very little interdependency between @entity565 , @entity484 , and allergic sensitization through childhood. The associations between those entities were strongly dependent on age, type of allergens, and method of testing for sensitization. Therefore, atopy in @entity1 is unlikely to represent a true endotype.
