Type II collagen-induced @entity8719 -like lesions in XXXX .

@entity1 @entity8719 @entity75 @entity3808 @entity35
@entity8719 -like lesions were induced in @entity35 by immunizing them with type II collagen. After seven months' immunization, the @entity35 were killed and processed for histologic study. We found @entity75 in the bony cochlea, vestibule, semicircular canal, and in the regions near the oval window and round window. The @entity75 in the otic capsules were similar to @entity1 @entity8719 and were characterized by the following types of microscopic appearances. 1) The classic type showed enlarged vascular spaces with congestion, macrophages, fibroblasts, and sometimes osteoclasts. 2) The fibrotic type showed vascular spaces filled with fibrous tissues. 3) The osteoporotic type had a porous appearance and was devoid of content. 4) The @entity3808 type showed bone spaces partially or entirely being replaced by new bone with blue mantles and a mosaic appearance. Some @entity75 showed a mixture of the above types. The findings suggest that this animal model may provide important information to help understand the process of @entity1 @entity8719 .
