The XXXX study in Taiwan.

@entity1 @entity2204 @entity303 @entity73 @entity195
Veterans General Hospital started study for @entity73 ( @entity73 ) since 1996. We used clinical @entity303 rating (CDR) of 0.5 to define our @entity303 ( @entity303 ) subjects. These @entity303 subjects received annual neuropsychological assessment in 5-year follow-up period. Annual conversion rate, @entity2204 ( @entity2204 ) genotype and neuropsychological risk factors for @entity303 were investigated. We found a 19.9% @entity1 -year conversion rate for these @entity303 subjects. Both of the poor cognitive performance and @entity2204 epsilon4 allele were risk factors for progressing to @entity303 . Based on the results of this study and the progress in the concept of @entity73 , we added more complex verbal and visual memory tests as well as MRI-based volumetry measurement in our subsequent research. Peterson's @entity73 criteria were used to diagnose our @entity73 subjects. In the 3-year follow-up period, the conversional rate was 18.2% @entity1 -year for @entity73 subjects, similar to our previous finding in @entity303 . We found hippocampal volume was positively associated with cognitive performance. @entity2204 genotype had effect on hippocampal volume. Subjects with lower cognitive performance and smaller hippocampi had higher risk converting to @entity195 . With rapidly expanding research on @entity303 and @entity73 worldwide, we are looking forward to seeing the integration in neurobiology, neuroimaging, and neurobehavior fields to establish a multidisciplinary approach to @entity73 and @entity303 .
