XXXX : @entity311 as a forgotten cause.

@entity1 @entity2167 @entity16 @entity2319 @entity9231 @entity6197 @entity311 @entity393
BACKGROUND: @entity2167 from antimalarials is a well publicised cause of @entity2319 and a great deal of time and resources are spent assessing it in relation to new drugs. The effect of the @entity311 parasite itself on hearing is, however, poorly documented and most evidence is anecdotal. This paper aims to collate existing evidence of this association. METHODS: Two systematic literature searches were performed on Ovid Medline, first for ' @entity311 ' and ' @entity393 ' or ' @entity393 ' or ' @entity2319 ', and secondly for ' @entity16 '. The articles were then individually studied for relevance. RESULTS: @entity311 has been implicated as a rare cause of @entity393 in various studies, but recommendations and hypotheses have not been taken seriously or investigated. Searches also returned numerous studies of @entity16 after @entity6197 , a small proportion of which observed hearing impairments on follow-up. However, no attempt was made to distinguish between treatment and disease as the cause. A few antimalarial drug trials which assessed hearing before treatment found unexplained @entity393 which improved with elimination of the parasite. CONCLUSION: Evidence from this review suggests that the @entity9231 parasite is a potential cause of @entity393 . @entity311 is a disease of such high prevalence that even if only a small proportion of survivors develop this impairment the effects on @entity1 's education could be detrimental. More attention should be focussed on investigating this association as the clinical and pathophysiological implications are potentially considerable.
