Clinical impact of @entity1014 phosphorylase expression in XXXX .

@entity1 @entity20941 @entity5 @entity35343 @entity1014 @entity1013 @entity356 @entity1487
@entity1014 phosphorylase (dThdPase) is an enzyme that is involved in @entity35343 metabolism and DNA synthesis and converts @entity20941 ( @entity1013 ) to @entity1487 ( @entity1487 ). The aim of this study was to elucidate the relationship between dThdPase expression and biological @entity5 , prognosis, and sensitivity to postoperative chemotherapy, using immunohistochemical staining. We studied 148 @entity1 with @entity356 who underwent surgery at Department of Surgery II in Oita Medical University between 1990 and 1999. Immunohistochemical expression of dThdPase was correlated to clinicopathological factors and postoperative survival. Tumor tissue was dThdPase-positive in 112 @entity1 . The results suggested a relationship between the degree of histological differentiation and dThdPase expression (p=0.0697). Examination of dThdPase expression based on the site of the @entity5 revealed that the groups with upper or lower @entity356 included a significantly greater number of dThdPase-positive @entity1 (p=0.0011). Analysis of the @entity1 as a whole showed no significant difference between the survival. In the chemotherapy group, the dThdPase-positive @entity1 tended to have a more favorable prognosis than the dThdPase-negative @entity1 (p=0.0578). The results suggest that postoperative adjuvant chemotherapy that makes use of FU metabolic pathways may improve prognosis in @entity1 with dThdPase-positive @entity356 .
