[The effects of electro-acupuncture on the signaling pathway of TLR/ @entity35721 in ankle joint synovial tissue of @entity3811 XXXX ].

@entity38337 @entity7126 @entity3811 @entity35721 @entity3812 @entity35 @entity21140 @entity414
OBJECTIVE: To investigate the effects of electro-acupuncture ( EA) on the related protein expression of the signaling pathway of the @entity21140 ( @entity21140 )/myeloid differentiation factor (MYD) 88 in ankle joint synovial tissue of @entity3811 ( @entity3811 ) @entity35 . METHODS: Fifty male SD @entity35 were randomly divided into 5 groups: normal group, @entity7126 group, @entity3811 model group, medication group and EA group, 10 @entity35 in each group. @entity7126 group established model by inducing @entity7126 , other groups established @entity3811 model by inducing @entity414 , except the normal group. Two days before model was established, normal and @entity7126 and @entity3811 model groups were lavaged with normal saline (20 mL/kg), medication group was lavaged with @entity3812 solution (1 mg/kg), EA (1. 5-2 Hz, D.-D. wave, 9 V, 1-3 mA) was applied to"Sanyinjiao" ( @entity38337 ),"Jiexi"(ST41) and "kunlun" (BL60) for 20 min, once daily, continuously for 9 days. Then the join sewlling index was observed periodically, the protein expression of @entity21140 and @entity35721 was determined by immunohistochemistry. RESULTS: Compared to the normal group, the join sewlling of the @entity7126 group in test join increased significantly (P<0. 05) and the protein expression of @entity21140 and @entity35721 in synovial tissue has not statistically significant (P>0.05), the oin sewlling and protein expression of @entity21140 and @entity35721 in synovial tissue of model group increased significantly P<0. 05); The medication and EA group compared to the model group, the protein expression of @entity21140 and @entity35721 in synovial tissue decreased significantly (P <0. 05), the join sewlling in test join decreased significantly P<1. 05); There were not statistically significant between the EA group and the medication group (P>0.05). CONCLUSION: EA can alleviate the symptoms of @entity3811 , which may be related to regulation of the protein expression Y TRI and @entity35721 in the TLR/ @entity35721 signaling pathway.
