High dose supplementation of XXXX decreases cellular hemostasis but accelerates plasmatic coagulation in @entity6 .

@entity1 @entity4051 @entity455 @entity270 @entity6 @entity1423 @entity26 @entity2279 @entity1881 @entity22891 @entity164 @entity10985
BACKGROUND: @entity6 is associated with increased generation of free @entity26 radicals and depleted scavenging potential (oxidative stress), leading to increased LDL oxidation and platelet hyperreactivity, the major components of @entity455 . A main goal of antioxidant therapy is to protect the LDL particle from atherogenic oxidation and to reduce the activated cellular hemostasis. METHODS: We evaluated the influence of a high dose supplementation with 800 IU of the natural antioxidant @entity22891 ( @entity270 ) per day for six months on serum levels, @entity270 load of LDL particles (HPLC), lag phase of LDL oxidation (Esterbauer's assay), platelet adhesion molecules, @entity1423 (flow cytometry, D-III protocol) and coagulation (INR/PTT) in a group of 36 @entity1 with @entity164 2 @entity6 (f/m 22/14; age 58+/-8.0; @entity4051 at baseline 10.25+/-1.7). RESULTS: Average @entity270 levels increased 2.65-fold accompanied by a 1.83-fold increase of LDL-associated @entity270 and a 12.3 min prolongation of the lag-phase of LDL oxidation (p<0.001 for all parameters at six months). Platelet expression of @entity2279 ( @entity2279 ) (-30.2% positive cells, p<0.001; antigen density -25%, p<0.001), @entity10985 ( @entity10985 ) (-2.9% positive cells, p<0.01; antigen density -10.6%, p<0.001) and fibrinogen (-1.6% positive cells, p<0.001; antigen density - 16.1 %, p<0.001) decreased. Concomitantly, platelet-leukocyte-coaggregation increased by 44% (p<0.001), correlating to an INR reduction of 10.4% (1.06+/-0.09 to 0.95+/-0.09, p<0.001, r = - 0.34). The PTT remained constant. CONCLUSION: The antioxidant protection from the increased @entity270 was accompanied by a decreased expression of constitutive and function-dependent platelet adhesion molecules. However, @entity1423 and a shortened INR time suggest extrinsic coagulation activation, possibly by induction of a leukocyte tissue factor dependent mechanism. High dose supplements of @entity1881 may override the available redox balance in well controlled @entity164 2 @entity6 . However, intrinsic effects of @entity1881 must be discussed.
