Acute exposure of the neonatal XXXX to @entity2384 results in decreases in biochemical indicators of synaptogenesis and myelinogenesis.

@entity8382 @entity2384 @entity2385 @entity35 @entity12220
Assays of neuron-localized (neurotypic) and glia-localized (gliotypic) proteins were used to detect and characterize the toxic effects of @entity2384 ( @entity2385 ) on the developing @entity35 central nervous system. Four proteins associated with specific aspects of neuronal and glial development were evaluated: 1) @entity12220 , a synaptic vesicle-associated protein; 2) neurofilament 200, an intermediate filament protein of the neuronal cytoskeleton; 3) @entity8382 , an oligodendroglia and myelin-sheath associated protein; and 4) glial fibrillary acidic protein, an intermediate filament protein of astrocytes. On postnatal days 13, 22 and 60, the amount of each protein in homogenates of cerebellum, forebrain and hippocampus was determined by radioimmunoassay. A single administration of @entity2385 (2, 3 or 4 mg/kg i.p.) on postnatal day 5 caused dose- and region-dependent decreases in brain weight with the cerebellum being most affected. These decrements were not associated with light microscopic evidence of altered brain development (on postnatal day 61) but were accompanied by large dose- and region-dependent decreases in @entity12220 and @entity8382 . Decrements in both the per tissue (total) and per milligram of tissue protein (concentration) values for these proteins were observed in cerebellum and forebrain; hippocampus was largely unaffected. @entity2385 -induced reductions in @entity12220 and @entity8382 were seen at dosages that did not affect brain, thymus or body weight. At dosages of @entity2385 that did not affect body weight, reductions in brain weight, @entity12220 and @entity8382 did not persist into adulthood. The data indicate that exposure to @entity2385 on postnatal day 5 is toxic to the developing nervous system.(ABSTRACT TRUNCATED AT 250 WORDS)
