A Novel Method for Sensitive Determination of Subclinical Left-Ventricular Systolic Dysfunction in Subjects With Obstructive Sleep XXXX .

@entity296 @entity27 @entity1002 @entity386
BACKGROUND: This study was to evaluate the subclinical @entity1002 with 2-dimensional speckle-tracking echocardiography in subjects with @entity27 ( @entity27 ) with normal left ventricular ejection fraction and without any confounding disease that can cause @entity296 . METHODS: Nineteen healthy individuals and 60 subjects with @entity27 were included in this study. According to the severity of disease, @entity27 subjects were examined in 3 groups: mild, moderate, and severe @entity27 . LV apical views (for longitudinal strain) and short-axis views (for circumferential strain) were acquired for evaluation. Three-layer longitudinal strain values and circumferential strain values were determined for each view, and averages of these were used in comparison with other groups. RESULTS: Three-layer longitudinal strain values of the subjects with @entity27 were lower than those of the healthy individuals, and these values were decreased along with the @entity27 severity. The difference was significant between severe @entity27 and all other groups. Three-layer circumferential strain values of the @entity27 subjects were lower than those of the healthy individuals, and the difference was significant between the control group and all other groups. The @entity386 hypopnea index was found to be correlated with the 3-layer longitudinal strain (r = -0.74, P < .001; r = -0.72, P < .001; r = -0.69, P = <.001). CONCLUSIONS: Three-layer longitudinal and circumferential LV systolic functions in @entity27 subjects with normal left ventricular ejection fraction are deteriorated in the subclinical stage. Two-dimensional speckle-tracking echocardiography can be used as an effective method in the determination of subclinical @entity296 in subjects with @entity27 .
