Toxic eosinophil granule protein deposition in corneal @entity1066 and scars associated with XXXX .

@entity1 @entity2610 @entity11153 @entity9849 @entity1066 @entity2687
PURPOSE: Recurrent or persistent @entity2687 and @entity1066 are typical complications of @entity9849 . Toxic eosinophil granule proteins such as major basic protein ( @entity2610 ) and @entity11153 ( @entity11153 ) may be involved in this pathogenetic process. This study was designed to demonstrate the presence of toxic eosinophil granule proteins in corneal tissue from a @entity1 with corneal complications of @entity9849 . DESIGN: Observational case report. METHODS: Three corneal buttons of a @entity1 with @entity9849 associated @entity1066 or scarring were examined by light microscopy and by immunofluorescence technique. RESULTS: A linear deposition of eosinophil granular substance was detected subepithelially above Bowman's membrane in all corneal buttons. Indirect immunofluorescence identified this material as @entity2610 and @entity11153 . The deposits were not limited to the area of ulceration, but were also found underneath intact corneal epithelium. Multiple eosinophils were present in the upper @entity2687 . Normal corneas and negative control sections of the pathologic buttons revealed only minimal nonspecific staining at the surface of the epithelium. CONCLUSIONS: Both @entity2610 and @entity11153 are known to affect @entity1 corneal epithelial cell viability and morphology in vitro. Moreover, @entity2610 was shown to inhibit epithelial migration and protein synthesis. These toxic eosinophil proteins may also be responsible for corneal instability, recurrent and persistent corneal epithelial defects and @entity1066 in @entity1 with @entity9849 .
