XXXX in @entity195 : role of the cingulate cortex.

@entity1 @entity303 @entity71 @entity51 @entity195 @entity4943
@entity51 is a symptom of @entity195 that can be observed even in the early stages of the disease. The frontal hypoperfusion associated with @entity71 has led to suggestions of the existence of a hypofunctioning prefrontal pathway involving the right dorsolateral prefrontal cortex, inferior parietal lobe, anterior cingulate gyri and limbic structures. Since this network plays an important role in response inhibition competence and @entity1 with @entity195 who are unaware of their deficits exhibit impaired performance in response inhibition tasks, we predicted a relationship between unawareness of @entity51 . We tested this hypothesis in a sample of 29 @entity1 with @entity195 (15 aware and 14 unaware of their disturbances), rating unawareness according to the Awareness of Deficit Questionnaire- @entity303 scale. The cognitive domain was investigated by means of a wide battery including tests on executive functioning, memory and language. Neuropsychiatric aspects were investigated using batteries on behavioural mood changes, such as @entity4943 . Cingulate functionality was assessed with functional magnetic resonance imaging, while @entity1 performed a go/no-go task. In accordance with our hypotheses, unaware @entity1 showed reduced task-sensitive activity in the right anterior cingulate area (Brodmann area 24) and in the rostral prefrontal cortex (Brodmann area 10). Unaware @entity1 also showed reduced activity in the right post-central gyrus (Brodmann area 2), in the associative cortical areas such as the right parietotemporal-occipital junction (Brodmann area 39) and the left temporal gyrus (Brodmann areas 21 and 38), in the striatum and in the cerebellum. These findings suggest that the @entity51 in early @entity195 is associated with reduced functional recruitment of the cingulofrontal and parietotemporal regions. Furthermore, in line with previous findings, we also found @entity4943 to be prominent features of the first behavioural changes in unaware @entity1 .
