Early pediatric @entity483 shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/ XXXX cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.

@entity1 @entity483 @entity404 @entity4047 @entity4666 @entity23906 @entity13236 @entity33356 @entity1198 @entity4155 @entity272 @entity405 @entity7986
BACKGROUND: Identifying differences and similarities between cutaneous lymphocyte antigen (CLA)(+) polarized T-cell subsets in @entity1 versus adults with @entity483 ( @entity483 ) is critical for directing new treatments toward @entity1 . OBJECTIVE: We sought to compare activation markers and frequencies of skin-homing (CLA(+)) versus systemic (CLA(-)) "polar" @entity404 and @entity405 T-cell subsets in @entity1 with early pediatric @entity483 , adults with @entity483 , and control subjects. METHODS: Flow cytometry was used to measure @entity7986 /inducible costimulator/HLA-DR frequency in memory cell subsets, as well as IFN-y, @entity4047 , @entity4666 , @entity4155 , and @entity13236 cytokines, defining @entity33356 , TH2/ @entity23906 , TH9/TC9, TH17/TC17, and TH22/TC22 populations in @entity404 and @entity405 cells, respectively. We compared peripheral blood from 19 @entity1 less than 5 years old and 42 adults with well-characterized moderate-to-severe @entity483 , as well as age-matched control subjects (17 @entity1 and 25 adults). RESULTS: Selective inducible costimulator activation (P < .001) was seen in @entity1 . CLA(+) TH2 T cells were markedly expanded in both @entity1 and adults with @entity483 compared with those in control subjects, but decreases in CLA(+) @entity1198 T-cell numbers were greater in @entity1 with @entity483 (17% vs 7.4%, P = .007). Unlike in adults, no imbalances were detected in CLA(-) T cells from pediatric @entity1 with @entity483 nor were there altered frequencies of TH22 T cells within the CLA(+) or CLA(-) compartments. Adults with @entity483 had increased frequencies of @entity13236 -producing @entity404 and @entity405 T cells within the skin-homing population, compared with controls (9.5% vs 4.5% and 8.6% vs 2.4%, respectively; P < .001), as well as increased HLA-DR activation (P < .01). CONCLUSIONS: These data suggest that TH2 activation within skin-homing T cells might drive @entity483 in @entity1 and that reduced counterregulation by @entity1198 T cells might contribute to excess TH2 activation. TH22 "spreading" of @entity483 is not seen in young @entity1 and might be influenced by immune development, disease chronicity, or recurrent @entity272 .
