Changes in @entity6587 induced by 4 weeks of treatment with antiasthmatic drugs in XXXX with @entity56 : a comparison between @entity4184 and @entity4183 .

@entity1 @entity1169 @entity56 @entity4184 @entity112 @entity6587 @entity4183
We performed a double-blind crossover study to compare the effects of long-term treatment of inhaled @entity4184 and @entity4183 on @entity6587 in 17 @entity1 with @entity56 . Both drugs were administered for 4 weeks with a placebo-treatment period before and after each active-treatment period. To assess @entity6587 , standardized inhalation provocation tests with @entity112 and @entity1169 were performed every 2 weeks. Before each inhalation provocation the drugs were withheld for at least 12 hours. Before the @entity4184 treatment the FEV1 value (percent predicted) was 85.3 +/- 4.1% (mean +/- SEM). After 2 and 4 weeks of treatment with this drug, the value increased significantly to 89.4 +/- 4.1% and 96.2 +/- 3.8%, respectively (p less than 0.05 and p less than 0.005). The @entity112 provocation concentrations causing a decrease in FEV1 of 20% (PC20) on the same days were 4.0, 7.2, and 9.5 mg/ml, respectively (both p less than 0.001). The PC20 values for @entity1169 , which were measured 1 hour after the @entity112 provocation, were 11.7, 13.3, and 14.0 mg/ml (ns). The FEV1 values before and after 2 and 4 weeks of treatment with @entity4183 were 86.2 +/- 4.0%, 84.8 +/- 4.1%, and 87.0 +/- 4.6%, respectively. The @entity112 PC20 values on the same days were 4.7, 3.1 (p less than 0.05), and 3.8 mg/ml, respectively. The @entity1169 PC20 values were 14.2, 8.7, and 10.1 mg/ml (p less than 0.001 and p less than 0.05, respectively. We conclude that @entity4184 improves @entity6587 , possibly by a dampening of late @entity56 , whereas treatment with @entity4183 may lead to a temporary increase of @entity6587 , possibly as a result of beta-receptor desensitization.
