Cerebral blood flow autoregulation and XXXX : possible causes of abnormal prenatal neurologic development.

@entity2500 @entity1699 @entity10584 @entity299 @entity2431
OBJECTIVE: To determine whether the major @entity299 ( @entity299 ) can modify the cerebrovascular flow dynamics and the biometrical parameters in fetuses at third trimester of pregnancy. METHODS: We studied 60 fetuses with CHD. Data included prenatal versus postnatal cardiac diagnosis, cerebral and umbilical artery doppler, fetal biometrical parameters, fetal weight, and gestational age. The pulsatility index (PI) was used to determine blood flow velocities in the umbilical artery (UA) and @entity2500 ( @entity2500 ), while the cerebro/placental ratio (CPR) was assessed as a measure of cerebral autoregulation. Fetuses with CHD were compared to normal controls and then analyzed after being divided into groups based on specific defects. RESULTS: Compared with control fetuses, those with CHD showed a decrease of resistance blood flow in the @entity2500 (1.76 vs 1.92 PI) especially considering the CPR (1.66 vs 2.03 PI) (p < 0.01). Furthermore, fetuses with CHD also had smaller head circumferences (30.6 cm vs 31.5 cm p < 0.01) and head/abdominal (HC/AC) ratio (1 vs 1.05 p < 0.01). When stratified for single @entity299 , fetuses with hypoplasic @entity1699 showed a lower CPR and HC/AC ratio. CONCLUSIONS: Cerebrovascular resistance is significantly lower in fetuses with CHD, especially in cases of @entity10584 . The cerebro/placental hemodynamic changes are similar to that described in fetuses with @entity2431 and may contribute to their abnormal neurologic development.
