Anal and neorectal function after ileal pouch-anal XXXX .

@entity1 @entity73 @entity254
Bowel function varies markedly among @entity1 with colectomy and ileal pouch-anal @entity254 . Little is known of the mechanisms controlling fecal continence and frequency of defecation after operation. The aim of this study was to determine which features of the anal sphincter and neorectum accounted for the variation in clinical outcome. Twenty @entity1 were studied 4 to 35 months after operation and compared to 12 healthy volunteers. Despite several @entity1 exhibiting @entity73 and ileal pouch capacity and distensibility were similar in @entity1 and controls. @entity1 with poor results, however, had rapid filling of their ileal pouch, which resulted in early onset of high amplitude propulsive pressure waves in the pouch. As these waves became more frequent, defecation resulted. @entity1 with poor results also were not able to empty adequately their pouch. The poorer the completeness of evacuation, the more frequent the defecation (r = 0.62, p less than 0.01). The authors conclude that rapid pouch filling and impaired pouch evacuation can lead to increased stool frequency in @entity1 after ileal pouch-anal @entity254 .
