Limb suction evoked during arterial occlusion causes systemic sympathetic activity in XXXX .

@entity1 @entity1211
UNASSIGNED: Venous saline infusions in an arterially occluded forearm evokes reflex increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP). We hypothesized that the application of suction to the @entity1 limbs would activate this @entity1211 reflex and raise sympathetic outflow. We placed airtight pressure tanks and applied 100 mmHg negative pressure to an arterially occluded limb (occlusion and suction, O_S) to induce tissue deformation without fluid translocation. BP, heart rate (HR), and MSNA were assessed in 19 healthy subjects during 2 minutes of arm or leg O_S. Occlusion without suction served as a control. During a separate visit, saline (5% forearm volume) was infused into veins of the arterially occluded arm (N = 13). The O_S increased limb circumference, MSNA burst rate (arm:   6.7    0.7; leg:   6.8    0.7 bursts/min) and total activity (arm:   199    14; leg:   172    22 units/min) and BP (arm:   4.3    0.3; leg:   9.4    1.4 mmHg) from the baseline. The MSNA and BP responses during arm O_S correlated with those during leg O_S. Occlusion alone had no effect on MSNA and BP. MSNA (R = 0.607) responses during arm O_S correlated with those evoked by the saline infusion into the arm. These correlations suggest that sympathetic activation during limb O_S is likely, at least partially, to be evoked via the @entity1211 reflex. These data suggest that suction of an occluded limb evokes sympathetic activation, and that the limb @entity1211 reflex exists in arms and legs of normal @entity1 .
