Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan) XXXX in Childhood.

@entity1 @entity2175 @entity882 @entity9058 @entity7063 @entity2150 @entity2590 @entity1503 @entity9957 @entity1398 @entity1200 @entity74 @entity236 @entity2131 @entity3043 @entity6349 @entity11807
Peripheral blood @entity1503 in @entity1 can be due to a variety of acquired or @entity74 . @entity74 affecting a single hematopoietic lineage are frequently characterized by typical @entity236 findings, such as lack of progenitors or @entity2175 arrest in @entity9957 or a lack of megakaryocytes in @entity882 , whereas antibody-mediated diseases such as @entity1398 are associated with a rather unremarkable @entity236 morphology. By contrast, @entity3043 is frequently associated with a hypocellular @entity236 , and the differential diagnosis includes acquired @entity2150 , @entity2590 , inherited @entity2131 such as @entity11807 and @entity7063 , and a variety of @entity1200 including @entity9058 . Thorough @entity236 analysis is of special importance for the diagnostic work-up of most @entity1 . Cellularity, cellular composition, and @entity6349 signs are the cornerstones of the differential diagnosis. @entity3043 in the presence of a normo- or @entity236 with @entity6349 changes may indicate @entity2590 . More challenging for the hematologist is the evaluation of the hypocellular @entity236 . Although @entity2150 and @entity1503 ( @entity1503 ) can reliably be differentiated on a morphological level, the overlapping pathophysiology remains a significant challenge for the choice of the therapeutic strategy. Furthermore, inherited @entity2131 are usually associated with the morphological picture of @entity1503 , and the recognition of these entities is essential as they often present a multisystem disease requiring different diagnostic and therapeutic approaches. This paper gives an overview over the different disease entities presenting with (pan) @entity1503 , their pathophysiology, characteristic @entity236 findings, and therapeutic approaches.
