Vertical growth phase and positive sentinel node in thin XXXX .

@entity1 @entity5 @entity1066 @entity1711 @entity1817 @entity1710 @entity3 @entity320
@entity1817 ( @entity1817 ) status is the most important prognostic factor for localized @entity320 . Usually, @entity1 with Breslow thickness of less than 1.0 mm are not included in @entity1817 protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin @entity320 . Ulceration, regression and high mitotic rate have been considered to be indications for an @entity1817 biopsy. The metastatic potential of the vertical growth phase is uncertain. To correlate pathological features in thin @entity320 with @entity1817 @entity3 , we reviewed 358 @entity1 submitted to @entity1817 biopsy. Seventy-seven @entity1 with lesions of 1 mm or smaller were included in the study group. Histological evaluation of the @entity5 included thickness, Clark level, mitotic rate, @entity1066 , regression, and growth phase. Lymphoscintigraphy was performed on all @entity1 . Lymphatic mapping and gamma probe detection were both used for @entity1817 biopsy. Histological examination of @entity1817 consisted of @entity1710 - @entity1711 and immunohistochemical staining. Median follow-up was 37 months. Six @entity1 had micrometastases. Statistical analysis by the Fisher test showed that @entity1066 (P = 0.019), high mitotic rate (P = 0.008) and vertical growth phase (P = 0.002) were positively correlated with micrometastases. If other studies confirm these results, more @entity320 @entity1 must be submitted to @entity1817 biopsy.
