Bone-Remodeling Transcript Levels Are Independent of Perching in End-of-Lay White Leghorn XXXX .

@entity1 @entity9723 @entity71918 @entity174 @entity170 @entity8377 @entity79 @entity1573 @entity39961 @entity46200 @entity71917 @entity39960
UNASSIGNED: @entity170 is a @entity79 that commonly results in a 30% incidence of @entity174 in hens used to produce eggs for @entity1 consumption. One of the causes of @entity170 is the lack of mechanical strain placed on weight-bearing bones. In conventionally-caged hens, there is inadequate space for @entity1573 to exercise and induce mechanical strain on their bones. One approach is to encourage mechanical stress on bones by the addition of perches to conventional cages. Our study focuses on the molecular mechanism of bone remodeling in end-of-lay hens (71 weeks) with access to perches. We examined bone-specific transcripts that are actively involved during development and remodeling. Using real-time quantitative PCR, we examined seven transcripts ( @entity9723 ), @entity39961 ( @entity39961 ), @entity39960 ( @entity39960 ), @entity46200 ( @entity46200 ), @entity71917 ( @entity71917 ), @entity71918 ( @entity71918 ), and @entity8377 (Sry-related high mobility group box)) in phalange, tibia and femur. Our results indicate that the only significant effect was a difference among bones for @entity9723 (femur > phalange). Therefore, we conclude that access to a perch did not alter transcript expression. Furthermore, because hens have been used as a model for @entity1 bone metabolism and @entity170 , the results indicate that bone remodeling due to mechanical loading in @entity1573 may be a product of different pathways than those involved in the @entity1 model.
