Multidrug resistance proteins in @entity2916 and XXXX .

@entity1 @entity410 @entity1262 @entity5 @entity75 @entity11092 @entity2916 @entity74 @entity302
@entity2916 is an @entity74 characterized by @entity410 that are refractory to medication in severely affected individuals. The mechanism involved in drug resistance in @entity2916 is unknown. The proteins @entity1262 (multidrug resistance) and @entity11092 ) are linked to chemotherapy resistance in @entity5 cells. However, the relationship between refractoriness to antiepileptic drugs and @entity1262 or @entity11092 brain expression has been poorly studied. We have previously described a case of @entity2916 with @entity302 that expressed multidrug resistance gene ( @entity1262 ) in tuber cells from @entity75 . In this retrospective study, we describe the expression of @entity1262 and @entity11092 in the @entity2916 of three pediatric @entity1 with @entity2916 and @entity302 surgically treated. Monoclonal antibodies for @entity1262 and @entity11092 proteins were used for immunohistochemistry. In epileptogenic cortical tuber brain specimens, @entity1262 and @entity11092 proteins were strongly immunoreactive in abnormal balloon cells, dysplastic neurons, astrocytes, microglial cells, and some blood-brain vessels. A more extensive @entity1262 immunoreactivity was observed. These data suggest that @entity302 phenotype in @entity2916 can be associated with the expression of both multidrug resistance @entity1262 and @entity11092 transporters in @entity2916 .
