D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute XXXX ?

@entity8 @entity3182 @entity1133 @entity3265 @entity11485 @entity879 @entity648 @entity409 @entity5906 @entity1372 @entity1578 @entity3929 @entity810 @entity1011 @entity35 @entity11659
BACKGROUND: Short-term administration of @entity11485 to experimental animals causes @entity409 and @entity879 ( @entity879 ), as well as @entity810 in some cases. The aim of our study was to describe @entity8 that developed in the course of @entity11485 -induced @entity1578 . MATERIAL AND METHODS: @entity35 were randomly divided into 2 groups: a study group administered @entity11485 intraperitoneally and a control group administered saline. RESULTS: All the animals in the study group developed @entity409 and failure within 48 h, with significant increase of @entity3929 (p<0.001), @entity5906 aminotransferases (p<0.0001), @entity648 (p<0.004), and @entity3265 (p<0.005) and decrease of albumin (p<0.001) concentrations. @entity810 was observed in all test animals, with a significant increase in @entity1011 (p<0.001) and @entity1133 (p<0.001) concentrations and a decrease in @entity1011 clearance (p<0.0012). Moreover, osmotic clearance (p<0.001), daily natriuresis (p<0.003), and fractional @entity1372 excretion (p<0.016) decreased significantly in this group of animals. The ratio of urine osmolality to serum osmolality did not change. Histopathology of the liver revealed @entity11659 , whereas renal histopathology showed no changes. CONCLUSIONS: @entity810 that developed in the course of @entity11485 -induced @entity879 was of a functional nature, with the kidneys retaining the ability to concentrate urine and retain @entity1372 , and there were no renal changes in the histopathological examination. It seems that the experimental model of @entity879 induced by @entity11485 can be viewed as a model of @entity3182 that occurs in the course of @entity879 .
