Ten-year follow-up of eyes treated with stereotactic fractionated external beam radiation for neovascular age-related XXXX .

@entity1940 @entity10691 @entity2318 @entity941 @entity989 @entity1020 @entity2297
PURPOSE: To determine the long-term effects of stereotactic fractionated external beam radiation on eyes treated for neovascular age-related @entity1020 . METHODS: A retrospective review of all eyes treated with stereotactic fractionated external beam radiation (20-40 Gy, 2-Gy fractions) between 1997 and 2000 was performed to identify eyes with >=  2-year follow-up for analysis. A subset was imaged prospectively using a high-resolution Fourier-domain optical coherence tomography. RESULTS: Among 94 eyes treated, 33 eyes (32 subjects) had >=  2-year follow-up information (mean follow-up, 6.2 years; range, 2-10 years). Final visual acuity ranged from 20/50 to no light perception. Final macular findings included central @entity10691 (49%), @entity2318 (30%), and active @entity1940 (9%). Fourier-domain optical coherence tomography images of three eyes with @entity10691 revealed photoreceptor layer loss within areas of @entity10691 with intact retinal morphology in areas of radiation exposure outside @entity10691 . @entity989 was suspected in 18% and confirmed by @entity941 angiography in 15%, ranging from mild to @entity2297 /phthisis bulbi (2 eyes). Mean time from stereotactic fractionated external beam radiation to development of @entity989 was 5.4 years (range, 1-10 years). CONCLUSION: A moderate rate of delayed @entity989 was noted in eyes with neovascular age-related @entity1020 treated with stereotactic fractionated external beam radiation. @entity10691 was a common finding.
