Early @entity356 of @entity2580 is more amenable to endoscopic treatment than is early XXXX of poorly differentiated @entity420 in select @entity5 conditions.

@entity1 @entity5 @entity1066 @entity2580 @entity3 @entity420 @entity356
BACKGROUND: Recently, endoscopic submucosal dissection has been carefully applied in early @entity356 (EGC) with undifferentiated type. However, there are no individual guidelines for endoscopic treatment of EGCs with poorly differentiated @entity420 or @entity2580 . The aim of this study was to investigate and compare the clinicopathologic features of these two types of EGC to guide the application of endoscopic treatment. METHODS: @entity1 to undergo radical gastrectomy for the treatment of EGC were selected for inclusion in this study. Histology was classified according to the Japanese @entity356 Association. Between January 2005 and December 2008, 288 @entity1 with poorly differentiated EGC and 419 @entity1 with signet ring cell EGC were enrolled. Their medical records were reviewed retrospectively. RESULTS: Compared with signet ring cell EGC, poorly differentiated EGC had higher rates of male gender, old age (>= 45  years), large @entity5 length (>20  mm), @entity1066 , @entity3 , @entity3 , and lymph node @entity3 . In the multivariate analyses, poorly differentiated EGC was significantly associated with @entity1066 (odds ratio [OR]: 2.4, 95% confidence interval [CI]: 1.5-3.8), @entity3 (OR: 3.6, 95% CI: 2.6-5.1) and @entity3 (OR: 2.0, 95% CI: 1.1-3.6) with a reference of signet ring cell EGC. The independent risk factors for lymph node @entity3 were large @entity5 length, @entity3 , and @entity3 in both types of EGC. Young age was an independent risk factor of lymph node @entity3 only in poorly differentiated EGC. CONCLUSIONS: Poorly differentiated EGC has clinicopathologic features that are less favorable to endoscopic treatment than are those of signet ring cell EGC. Therefore, these two types of EGC should be approached separately, not as a united type of undifferentiated histology, during the planning of endoscopic treatment.
