Evidence for spontaneous immunosuppression in XXXX .

@entity1 @entity2835 @entity1560 @entity409 @entity3619 @entity116 @entity775
@entity775 ( @entity775 ) runs a variable clinical course. Slow disease progression or even spontaneous remissions can be observed and suggest that the autoimmune process can, at least to a certain extent, be controlled by regulatory elements of the @entity1 's own immune system. In experimental @entity775 (EAH) spontaneous recovery is regularly observed and associated with antigen-specific and antigen-nonspecific suppression. The aim of the current study was to search for similar immunoregulatory phenomena in @entity1 with @entity775 . We examined T-cell reactivity to soluble human liver antigens in 11 @entity1 with active @entity775 and 30 @entity1 with other @entity409 ( @entity3619 , @entity2835 , @entity1560 ). T-cell reactivity to liver antigens was almost exclusively confined to the @entity775 @entity1 . In 9 of these 11 @entity1 we were able to compare the T-cell response in active untreated disease, directly after initiation of immunosuppressive therapy and in remission, at which point T-cell reactivity was found to be markedly reduced. Addition of irradiated peripheral blood cells from the active disease phase or the remission phase to the responding cells taken before treatment showed that in eight of the nine @entity1 there was marked suppression of the liver-specific T-cell response by cells from the remission phase. Study of the in vivo immune responsiveness by giving a @entity116 toxoid booster immunization to nine @entity1 with active untreated @entity775 as well as healthy controls and @entity1 with other @entity409 showed that none of the @entity1 with @entity775 showed a response to the @entity116 immunization, whereas almost all the other @entity1 showed marked responses.(ABSTRACT TRUNCATED AT 250 WORDS)
