Numbers and types of nonbladder syndromes as risk factors for XXXX / @entity2336 .

@entity1 @entity239 @entity1494 @entity2337 @entity566 @entity6575 @entity2336 @entity1744 @entity5815 @entity2335
OBJECTIVES: To examine the interaction of types and numbers of antecedent nonbladder syndromes (NBSs) to seek clues to the pathogenesis of @entity2335 / @entity2336 ( @entity2337 /PBS). Numerous case series have shown @entity2337 /PBS to be associated with several syndromes that do not include @entity1494 . In a previously reported case-control study, we confirmed these findings and found that such nonbladder syndromes often preceded the onset of @entity2337 /PBS. METHODS: Incident female @entity2337 /PBS cases (n = 312) and matched controls were compared for 11 antecedent NBSs. The odds ratios (ORs) for @entity2337 /PBS according to the number of antecedent NBSs per @entity1 were calculated. From this model, each @entity6575 was serially removed, and the calculations for the ORs were repeated using the remaining 10 NBSs. We assessed the types of NBSs included in each subgroup formed by the number of NBSs. RESULTS: The ORs for @entity2337 /PBS increased with the increasing number of antecedent NBSs. The types of NBSs were interchangeable in calculating these ORs. The distribution of the types of NBSs was skewed, with @entity566 overrepresented in those with few NBSs, and the classic functional somatic syndromes of @entity239 , @entity5815 , and @entity1744 overrepresented in those with many NBSs. CONCLUSIONS: Two main hypotheses were generated. One was that the incidence of a @entity6575 initiated a process that contributed to the emergence of other NBSs and @entity2337 /PBS. The second was that each @entity6575 and @entity2337 /PBS was a manifestation of a common, shared pathogenesis. It is likely that a well-designed prospective study will be necessary to distinguish between these 2 hypotheses.
