Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in XXXX with @entity22 .

@entity1 @entity73 @entity854 @entity15131 @entity25 @entity22
STUDY OBJECTIVES: Recent studies have suggested that structural @entity854 may be linked with alterations in the @entity15131 ( @entity15131 ). This study compared cortical thickness and structural connectivity linked to the @entity15131 in @entity1 with persistent @entity22 (PI) and @entity25 ( @entity25 ). METHODS: The current study used a clinical subsample from the longitudinal community-based Korean Genome and Epidemiology Study (KoGES). Cortical thickness and structural connectivity linked to the @entity15131 in @entity1 with persistent @entity22 symptoms (PIS; n = 57) were compared to @entity25 ( @entity25 ; n = 40). All @entity1 underwent MRI acquisition. Based on literature review, we selected cortical regions corresponding to the @entity15131 . A seed-based structural covariance analysis measured cortical thickness correlation between each seed region of the @entity15131 and other cortical areas. Association of cortical thickness and covariance with sleep quality and neuropsychological assessments were further assessed. RESULTS: Compared to @entity25 , cortical thinning was found in PIS in the anterior cingulate cortex, precentral cortex, and lateral prefrontal cortex. Decreased structural connectivity between anterior and posterior regions of the @entity15131 was observed in the PIS group. Decreased structural covariance within the @entity15131 was associated with higher PSQI scores. Cortical thinning in the lateral frontal lobe was related to poor performance in executive function in PIS. CONCLUSION: Disrupted structural covariance network in PIS might reflect malfunctioning of antero-posterior disconnection of the @entity15131 during the wake to sleep transition that is commonly found during normal sleep. The observed structural network alteration may further implicate commonly observed sustained sleep @entity73 in @entity22 .
