XXXX of the skin: a clinicopathologic study of 10 cases and review of the literature.

@entity1 @entity2283 @entity588 @entity5 @entity4483 @entity3778 @entity2277 @entity2280 @entity21939 @entity2460
@entity2460 ( @entity2460 ) is a relatively uncommon @entity5 that most commonly arises in the pleura. However, @entity2460 is now known to affect various other anatomic sites as well, including rare examples in the skin, where the histologic features of this lesion may create diagnostic confusion with a variety of other spindle-cell @entity5 . In order to further the characterization of cutaneous @entity2460 , all available cases of that entity were retrieved from the authors' institutional files. Immunohistochemical analysis for @entity2280 , @entity3778 , @entity2277 , @entity588 , @entity21939 , @entity4483 protein, smooth muscle actin, pankeratin, epithelial membrane antigen (EMA) and @entity2283 was performed on those @entity5 and the corresponding clinical information was obtained whenever possible. There were eight @entity1 and two @entity1 in the study group, with a median age of 43 years. Sites of involvement included the trunk (two cases), cheek (two), scalp (one), forehead (one), lip (one), temple (one), heel (one) and toe (one). All @entity1 were treated with local excision; only one lesion recurred locally, but it required multiple re-excisions. All of the @entity5 were composed of bland spindle cells with a variably fibrous but focally hyalinized collagenous stroma. A variety of case-specific growth patterns were observed. Mitoses were generally rare, ranging from 0 to 3 per 10 x400 microscopic fields. Immunostains showed reactivity for @entity2277 in all SFTs, @entity2280 in 8 of 10 cases, @entity3778 and @entity588 in 4 of 10 (each) and smooth-muscle actin in 3 of 10 cases. None of the lesions was labeled for @entity21939 , keratin, EMA, @entity2283 or @entity4483 protein. @entity2460 of the skin appears to be a 'borderline' @entity5 that only uncommonly recurs. Immunoreactivity for @entity2280 , - especially together with @entity588 or @entity3778 , or both - is helpful in identifying this @entity5 .
