Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a @entity1707 model of complex vascular, splenic, and XXXX .

@entity1707 @entity712 @entity2332 @entity548 @entity3313 @entity1049 @entity260 @entity51 @entity86 @entity1744 @entity130
BACKGROUND: Induction of a profound @entity2332 for emergency preservation and resuscitation in severe @entity548 can improve survival from lethal @entity130 , but the impact of @entity2332 on @entity548 and infectious complications has not been completely determined. STUDY DESIGN: Uncontrolled @entity548 was induced in 26 @entity1707 (95 to 135 lbs) by creating an iliac artery and @entity130 , and 30 minutes later, by lacerating the descending thoracic aorta. Through a left thoracotomy approach, profound total body @entity2332 (10 degrees C) was induced (2 degrees C/min) by infusing cold organ preservation solution into the aorta. The experimental groups were: vascular @entity130 alone (group 1, n=10), vascular and @entity1049 (group 2, n=8), and vascular, colon, and @entity130 (group 3, n=8). All @entity130 were repaired during 60 minutes of low-flow cardiopulmonary bypass (CPB) with hemodilution and profound @entity2332 ; then the animals were slowly rewarmed (0.5 degrees C/min) back to normothermia. Survivors were monitored for 6 weeks for @entity86 , @entity51 , cognitive function (learning new skills), organ dysfunction, and septic complications. RESULTS: Six-week survival rates were 90% in group 1, 87.5% in group 2, and 75% in group 3 (p > 0.05). One animal in each group died from @entity712 during the early postoperative phase. Splenic salvage was possible in all animals, and none required complete splenectomy for @entity548 control. All surviving animals were neurologically intact, displayed normal learning capacity, and had no longterm organ dysfunction. None of the animals had @entity86 or experienced septic complications. One animal in group 3 died on the ninth postoperative day because of @entity1744 ( @entity3313 ). CONCLUSIONS: Induction of profound @entity2332 can preserve the viability of key organs during repair of lethal @entity130 . This strategy can be used even in the presence of solid organ and bowel @entity130 to improve survival, without any considerable @entity260 rates.
