Relative influence of XXXX and insulin in the regulation of prostatic cell proliferation and growth.

@entity1 @entity251 @entity1069 @entity1067 @entity3839 @entity1975 @entity8683 @entity35 @entity4124 @entity3800
@entity1067 is a common problem of the aged @entity1 population. Recent experimental and clinical studies provide sufficient evidence that apart from @entity3800 , insulin also plays an important role in the pathogenesis of @entity1067 . The present study was aimed to investigate the relative influence of @entity251 and insulin on the cellular proliferation and prostatic growth. Effect of @entity251 on the prostate of hypoinsulinemic, and glandular injection of @entity8683 antagonist S961 on the prostate of castrated @entity35 (220  10 g) was examined. Significant decrease in the weight of the ventral prostate was observed in the @entity3839 -induced hypoinsulinemic @entity35 (~6 fold), which is restored by the intervention of @entity251 . Although, glandular injection of S961 did not led to any change in the frequency of @entity1975 ( @entity1975 ) positive cells in normal @entity35 , significant decrease was observed in the castrated @entity35 . Castration led to increase in the frequency of the @entity4124 and the TUNEL positive cells in the ventral prostate. Further, long-term (6 weeks) administration of S961 induced significant decrease in the weight of the ventral prostate. Results of the present study provide that both @entity251 and insulin promote prostatic cell proliferation and change in the level of either of the hormone results in the destabilization of cellular equilibrium, and modulation of the @entity8683 signaling in the prostate may provide an alternative strategy for the treatment of @entity1069 . Further, studies are required to better understand the interplay between these hormones in the regulation of prostatic growth.
