Expression of growth factors and their receptors in XXXX and the implication for its histogenesis.

@entity7197 @entity5 @entity470 @entity52362 @entity540 @entity4179 @entity9051 @entity7167
@entity52362 is a rare @entity5 with (immuno-) histological features of epithelial cells, surrounded by various amounts of osteofibrous tissue. Recent studies have indicated that cells with an epithelial phenotype are most probably the malignant element. There is still debate as to whether the fibrous part should be designed as a benign neoplastic element of a @entity5 or as a reactive non-neoplastic tissue next to an epithelioid @entity5 . The expression of @entity540 ( @entity540 ), @entity4179 ( @entity4179 ), and their respective receptors @entity7167 and @entity470 , as well as the proliferation marker Ki-67, was studied in both constituents of @entity7197 in serial sections of 25 cases by immunohistochemistry. Expression of @entity540 and its receptor was present in both constituents of @entity7197 , but predominated in the epithelial component. Expression of @entity4179 and its receptor was restricted to the epithelial component of @entity7197 . Comparing @entity9051 ( @entity9051 )-like @entity7197 with classic epithelial cell-rich @entity7197 , the expression of @entity540 , @entity4179 , and @entity470 was more intense and in a higher percentage of cells in classic @entity7197 . Proliferative activity was found nearly exclusively in the epithelial component. These data further substantiate the hypothesis that epithelial cells constitute the proliferating @entity5 cell population responsible for the malignant behaviour of @entity7197 . The data indicate that during progression, the epithelial cells acquire expression of @entity540 , @entity4179 , and @entity470 , accompanied by a higher proliferative activity. Within the epithelial cell population, there exists an autocrine pathway of growth stimulation. Furthermore, these data point to an interaction between the epithelial and fibrous components, in which the epithelial cells additionally stimulate fibrous cell growth via a paracrine pathway involving @entity540 .
