Microvessel density correlates with lymph node XXXX and prognosis in @entity201 .

@entity1 @entity5 @entity2295 @entity2279 @entity201 @entity3
BACKGROUND: Neovascularization was shown to be critically involved in the progression of @entity5 , and treatment approaches targeting @entity5 -associated @entity2295 provide convincing results in recent years in some @entity5 entities. However, little is known about the @entity5 -associated @entity2295 in @entity201 . The present study was conducted to analyze @entity5 -associated @entity2295 in @entity201 and to determine its influence on @entity5 growth, @entity3 , recurrence, and prognosis. METHODS: We analyzed tissue specimens of @entity201 (n = 60) by immunohistochemistry using the endothelial-specific antibody @entity2279 and subsequently quantified the microvessel density (MVD). The MVD was correlated with clinicopathological characteristics and recurrence pattern of the @entity5 as well as survival of @entity1 . RESULTS: @entity201 revealed a high degree of vascularization, with a calculated mean MVD of 28.1 +/- 14.5 vessels. @entity5 with a high MVD had a significant higher incidence of lymph node involvement (P = 0.009) and local recurrence (P < 0.001). Furthermore, a high MVD was identified to be a significant overall survival disadvantage (3-year, 28% vs. 93%; 5-year, 8% vs. 78%; P < 0.001) as well as disease-free survival disadvantage (3-year, 7% vs. 88%, 5-year, 7% vs. 72%; P < 0.001), with MVD representing an independent prognostic factor for survival. CONCLUSIONS: Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of @entity201 . Therefore, @entity5 -associated @entity2295 seems to be critically involved in the progression of this @entity5 entity. In addition, @entity2295 may represent a potential target in he development of new therapeutic approaches in @entity201 .
