Increased and correlated expression of connective tissue growth factor and XXXX in surgically removed periodontal tissues with @entity7278 .

@entity1 @entity7278 @entity2533 @entity2521 @entity12020
BACKGROUND AND OBJECTIVE: Both gingival tissue destruction and regeneration are associated with @entity7278 , although the former overwhelms the latter. Studies have shown that @entity2533 ( @entity2533 ), a growth factor largely involved in tissue regeneration and remodeling, is upregulated in @entity7278 . However, the gingival expression of connective tissue growth factor ( @entity12020 or @entity12020 ), a @entity2533 -upregulated gene, in @entity1 with @entity2521 remains undetermined. Although both @entity12020 / @entity12020 and @entity2533 increase the production of extracellular matrix, they have many different biological functions. Therefore, it is important to delineate the impact of @entity2521 on gingival @entity12020 / @entity12020 expression. MATERIAL AND METHODS: Periodontal tissue specimens were collected from seven individuals without @entity2521 (group 1) and from 14 with @entity2521 (group 2). The expression of @entity12020 and @entity2533 mRNAs were quantified using real-time PCR. RESULTS: Analysis using the nonparametric Mann-Whitney U-test showed that the levels of expression of both @entity12020 / @entity12020 and @entity2533 mRNAs were significantly increased in individuals with @entity2521 compared with individuals without @entity2521 . Furthermore, analysis using a nonparametric correlation (Spearman r) test showed a positive correlation between @entity2533 and @entity12020 / @entity12020 mRNAs. CONCLUSION: The gingival expression levels of @entity12020 / @entity12020 and @entity2533 mRNAs in individuals with @entity2521 are upregulated and correlated.
