Predictors of survival following trans-catheter aortic valve closure for left ventricular assist device associated XXXX .

@entity1 @entity67 @entity712 @entity337
OBJECTIVE: This study sought to assess the long-term clinical benefits and predictors of survival of trans-catheter aortic valve closure in left ventricular assist device (LVAD) @entity1 . BACKGROUND: LVADs have been shown to increase survival and quality of life in @entity1 with end-stage @entity712 . However, severe @entity337 ( @entity337 ) can develop in up to 50% of @entity1 at 12 months resulting in significant morbidity and mortality. Trans-catheter treatment of LVAD associated @entity337 has emerged as a potential alternative to surgical treatment. METHODS: We conducted a retrospective analysis of all @entity1 undergoing trans-catheter aortic valve closure using an Amplatzer Multi-Fenestrated Septal Occluder "Cribriform" device to assess potential clinical and procedural factors associated with survival. Student's t-tests were used to compare baseline @entity1 demographics and procedural characteristics, as well as @entity1 outcomes immediately post procedure and at 6 months. A P-value of less than 0.05 was considered statistically significant. RESULTS: A total of 10 @entity1 (70% male, median age 59 years) were included. Technical success was accomplished in 100% of @entity1 with a 6 month survival rate of 30% (3/10). Compared with survivors, non-survivors had a higher rate of pre-procedural clinical co-morbidities, an increased likelihood of @entity67 , and received larger occluder devices. CONCLUSIONS: Trans-catheter aortic valve closure successfully treats late severe @entity337 in LVAD @entity1 , however, the presence or development of @entity712 portends a worse prognosis. Further studies are needed to investigate the factors involved in the development of @entity67 , and potential treatment, in @entity1 undergoing trans-catheter aortic valve closure.    2015 Wiley Periodicals, Inc.
