Role of thalamic diffusion for disease differentiation between XXXX and ischemic cerebral small vessel disease.

@entity1 @entity15 @entity353 @entity6249
INTRODUCTION: @entity6249 ( @entity6249 ) and @entity15 ( @entity15 ) both harbor multiple, T2-hyperintense white matter lesions on conventional magnetic resonance imaging (MRI).We aimed to determine the microstructural changes via @entity353 ( @entity353 ) in normal appearing thalami. We hypothesized that the apparent diffusion coefficient (ADC) values would be different in @entity6249 and @entity15 , since the extent of arterial involvement is different in these two diseases. METHODS: @entity353 was performed for 50 @entity1 with @entity6249 and 35 @entity1 with @entity15 along with gender- and age-matched controls whose conventional MRI revealed normal findings. @entity353 was done with 1.5 Tesla MR devices using echo planar imaging (EPI) for b   =   0, 1000  s/mm(2). ADC values were obtained from the thalami which appeared normal on T2-weighted and FLAIR images. Standard oval regions of interest (ROIs) of 0.5  cm(2) which were oriented parallel to the long axis of the thalamus were used for this purpose. RESULTS: The mean ADC value of the thalamus was (0.99        0.16)   *   10(-3)  mm(2)/s in @entity1 with @entity6249 , whereas the mean ADC value was (0.78        0.06)   *   10(-3)  mm(2)/s in the control group. The mean ADC value was significantly higher in @entity1 with @entity6249 compared to the controls (p   <   0.001). The mean ADC values of the thalamus were (0.78        0.08)   *   10(-3)  mm(2)/s in @entity15 @entity1 , and (0.75        0.08)   *   10(-3)  mm(2)/s in the control group, which are not significantly different (p   >   0.05). CONCLUSION: Our study revealed a difference in the diffusion of the thalami between @entity6249 and @entity15 . @entity353 may aid in the radiological disease differentiation.
