XXXX -associated mortality in Shanghai, China: a longitudinal study.

@entity1 @entity378 @entity204
OBJECTIVE: To determine excess mortality in a cohort of @entity1 with @entity378 in Shanghai. METHODS: @entity1 were local residents in 4 (of 19) districts in Shanghai, registered in one of four @entity378 clinics between January  1, 2004 and December 31, 2008. Baseline data were collected at the most recent diagnosis of @entity378 and mortality was assessed between March and May of 2014. We calculated standardized mortality ratios (SMR) and case-fatality rates for all @entity1 and for subgroups. Univariate and multivariate Cox regression models were used to quantify associations between co-morbidities and mortality from all causes and from @entity378 . FINDINGS: We registered 4569 subjects in the cohort. Overall, the cohort had an SMR for deaths from all causes of 5.2 (95% confidence interval, CI: 4.8-5.6). Males had a higher SMR than females (6.1 versus 3.0). After adjustment for age and sex, hazard ratios (HR) for deaths from all causes were significantly greater in previously treated @entity1 (HR: 1.26; 95% CI: 1.08-1.49) and sputum smear-test positive @entity1 (HR: 1.55; 95% CI: 1.35-1.78). The risk of @entity204 from @entity378 was also significantly greater for previously treated @entity1 (HR: 1.88; 95% CI: 1.24-2.86) and smear positive @entity1 (HR: 3.16; 95% CI: 2.06-4.87). CONCLUSION: @entity1 with @entity378 in Shanghai have an increased risk of mortality. Earlier diagnosis and more vigilant follow-up may help to reduce mortality in this group.
