XXXX at a tertiary hospital 1973-99.

@entity1 @entity410 @entity3036 @entity532
BACKGROUND: To investigate changes in incidence, @entity1 characteristics, comorbidity and in the care provided in cases of @entity3036 at a tertiary hospital during the period 1973-99. METHODS: Thirty-nine cases were identified through the Swedish National Birth Registry. Incidences and rates regarding @entity1 characteristics and outcomes (duration of intensive care unit surveillance, assisted ventilation, multiple @entity410 , @entity532 , perinatal mortality, small for gestational age, and neonatal intensive care surveillance) were compared between the time periods 1973-79, 1980-89 and 1990-99 with trend analysis. RESULTS: The incidences in the three time periods were 3.0/10,000 births [95% confidence interval (CI) 0.1-5.9], 6.2/10,000 births (95% CI 2.7-9.7) and 10.9/10,000 births (95% CI 6.4-15.4), respectively, which constitutes a significant difference according to trend analysis (p = 0.006). There were no differences in @entity1 characteristics or comorbidity. Onset occurred in hospital in 85% of the cases. CONCLUSIONS: The increase in the incidence of @entity3036 reported here is contrary to international trends up until the early 1990s. The incidence in 1990-99 is also higher than the reported national incidence in Sweden 1976-80, which was 2.9/10,000 births. Despite successful identification of @entity1 at risk for @entity3036 and hospital surveillance, several cases were not prevented. Better prognostic tests that identify impending @entity3036 are needed to bring the incidence down further.
