The sharp decline of beta XXXX receptors expression in long-lasting @entity189 .

@entity172 @entity1 @entity1782 @entity5 @entity31 @entity189 @entity29 @entity1783 @entity14 @entity204 @entity1141
OBJECTIVE: @entity14 is an important cause of @entity204 in @entity29 , thus requiring surveillance for @entity1141 in long-standing @entity31 ( @entity31 ). Females show a lower incidence probably related to hormonal factors; therefore, a role of @entity172 receptors (ERs) has been supposed in @entity189 ( @entity189 ) development. Our aim was to identify @entity1783 /alpha expression in long-lasting pancolitis through each grade of @entity1141 to @entity189 and, furthermore, to investigate the simultaneous epithelial apoptosis/proliferation. MATERIALS AND METHODS: Forty-eight @entity1 affected by long-lasting pancolitis were retrospectively investigated. Samples were divided into four groups: @entity31 , low-grade @entity1141 /high-grade @entity1141 ( @entity31 -HGD), and @entity189 . Normal colon samples were used as controls. @entity1783 , @entity1782 , Ki-67, and TUNEL expression (labeling/H index) were evaluated by immunohistochemistry. RESULTS: @entity1783 expression revealed an impressive reduction in @entity189 (10.4    5.1; p < 0.001) compared to controls and @entity31 (34.3    3.1 and 26.8    7.8, respectively), meanwhile @entity1783 level in LGD (29.4    3.7) was comparable to @entity31 . As far @entity1783 / @entity1782 mean value ratio revealed a progressive reduction. Ki67 demonstrated a progressive significant increase from @entity31 until @entity189 (37.9    6.4 < 45.7    6.2 < 60.6    5.2 < 71.1    5.1; p < 0.001). Apoptotic index (TUNEL) revealed a strong fall in @entity31 -HGD and @entity189 . CONCLUSIONS: @entity1783 fall could be considered as a biomarker of @entity31 progression. It occurs in HGD and overt @entity5 , while in LGD shows a normal expression. At the moment, we are unable to use this tool in the clinical practice to predict @entity5 progression, but it would be appropriate to encourage ER expression investigations in large samples for the interesting perspectives of application.
