Work Disability among Employees with XXXX : Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies.

@entity1 @entity6 @entity28 @entity1109 @entity2048 @entity717 @entity285
BACKGROUND: Studies of @entity717 in @entity6 have examined @entity6 as a homogeneous disease. We sought to identify subgroups among @entity1 with @entity6 based on potential risk factors for @entity717 . METHODS: @entity1 were 2,445 employees with @entity6 from three prospective cohorts (the Finnish Public Sector study, the GAZEL study, and the Whitehall II study). Work disability was ascertained via linkage to registers of sickness @entity2048 and disability pensions during a follow-up of 4 years. Study-specific latent class analysis was used to identify subgroups according to prevalent comorbid disease and health-risk behaviours. Study-specific associations with @entity717 at follow-up were pooled using fixed-effects meta-analysis. RESULTS: Separate latent class analyses for @entity1 and @entity1 in each cohort supported a two-class solution with one subgroup (total n = 1,086; 44.4%) having high prevalence of chronic somatic diseases, @entity1109 , @entity28 , physical inactivity and abstinence from @entity285 and the other subgroup (total n = 1,359; 55.6%) low prevalence of these factors. In the adjusted meta-analyses, @entity1 in the 'high-risk' group had more @entity717 days (pooled rate ratio = 1.66, 95% CI 1.38-1.99) and more @entity717 episodes (pooled rate ratio = 1.33, 95% CI 1.21-1.46). These associations were similar in @entity1 and @entity1 , younger and older @entity1 , and across occupational groups. CONCLUSIONS: @entity6 is not a homogeneous disease in terms of @entity717 risk. Approximately half of @entity1 with @entity6 are assigned to a subgroup characterised by clustering of comorbid health conditions, @entity28 , physical inactivity, abstinence of @entity285 , and associated high risk of @entity717 ; the other half to a subgroup characterised by a more favourable risk profile.
