XXXX of @entity15767 and @entity20302 : quantitative structure-activity relationships based on Kow and LC50.

@entity1 @entity20302 @entity137 @entity11379 @entity19 @entity3678 @entity15767 @entity2083
Recent EPA scrutiny of @entity3678 and @entity11379 monomers has resulted in restrictive consent orders and Significant New Use Rules under the Toxic Substances Control Act, based on structure-activity relationships using @entity19 skin painting studies. The concern is centered on @entity1 health issues regarding worker and consumer exposure. Environmental issues, such as @entity137 , are still of concern. Understanding the relationships and environmental risks to aquatic organisms may improve the understanding of the potential risks to @entity1 health. This study evaluates the quantitative structure-activity relationships from measured log Kow's and log LC50's for Pimephales promelas (fathead minnow) and @entity2083 ( @entity2083 ). Scientific support of the current regulations is also addressed. Two monomer classes were designated: @entity15767 and @entity20302 . Spearman rank correlation and linear regression were run. Based on this study, an ecotoxicological difference exists between @entity15767 and @entity20302 . Regulatory activities and scientific study should reflect this difference.
