The place of exercise in the long-term treatment of XXXX .

@entity1 @entity101 @entity1063 @entity413 @entity165
The antihypertensive effects of exercise have been examined in 2 randomized studies of multiple levels of activity. In 12 normal subjects, 1 month's exercise 3 times weekly lowered blood pressure (BP) and vascular resistance. There was only a slightly greater effect after 7 times/week exercise. In most subjects there was a marked reduction in @entity1063 spillover rate, a measure of sympathetic activity. Exercise also improved @entity413 utilization and lowered plasma @entity165 . Thirteen previously untreated @entity1 with essential @entity101 had an average fall in BP of 11/9 and 16/11 mm Hg after 1 month each of 3/week and 7/week exercise respectively, again associated with fall in vascular resistance and a 20-30% reduction in plasma @entity1063 . BP remained lowered by 3/week exercise for 1 year. In @entity1 who had BP controlled with drug for greater than 1 year, exercise 3 times weekly also prevented the redevelopment of @entity101 after long-term drug therapy was ceased. Regular exercise is useful in the initial management of @entity1 with mild @entity101 . In more severely @entity101 @entity1 , exercise may also be effective after an initial period of drug therapy.
