Reorganization of functionally connected brain subnetworks in high-functioning XXXX .

@entity1 @entity75 @entity2438 @entity72 @entity1315 @entity15131
UNASSIGNED: Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having @entity72 ( @entity72 ). Here we studied @entity75 subnetworks in high-functioning individuals with @entity72 during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with @entity72 ) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with @entity72 ) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of @entity15131 and @entity1315 ( @entity1315 ) subnetworks. The @entity1315 subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, @entity1315 subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with @entity2438 quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with @entity72 clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the @entity1315 subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all @entity1 . These findings suggest a pivotal role of ventro-temporal and limbic systems in @entity2438 . Hum Brain Mapp 37:1066-1079, 2016.    2015 Wiley Periodicals, Inc.
