Pressure Changes Within the Sac of @entity1 XXXX in Response to Artificially Induced Transient Increases in Systemic Blood Pressure.

@entity1 @entity101 @entity5748 @entity439 @entity2647 @entity438
UNASSIGNED: Formation and rupture of @entity438 have been associated with chronic @entity101 . The effect of transient increase in blood pressure and its effect on intra-aneurysmal hemodynamics have not been studied. We examined the effects of controlled increases in blood pressure on different pressure parameters inside the sac of @entity1 @entity438 and corresponding parent arteries using invasive technology. Twelve @entity1 (10 female, 2 male, age 54  15 years) with unruptured @entity438 undergoing endovascular coiling were recruited. @entity5748 with the capacity to simultaneously measure flow velocity and pressure were used to measure systolic, diastolic, and mean pressure inside the @entity439 sac and to measure both pressures and flow velocities in the feeder vessel just outside the @entity439 . These pressures were recorded simultaneously with pressures from a radial arterial catheter. Measurements were taken at baseline and then during a gradual increase in systemic systolic blood pressure to a target value of    25 mm Hg above baseline, using a @entity2647 infusion. The dose needed to achieve the required increase in radial arterial systolic blood pressure was 0.8  0.2  g/kg/min. There was a clear linear relationship between changes in radial and aneurysmal pressures with substantial @entity1 -by- @entity1 variation in the slopes of those relationships. The overall increases in systolic and mean pressures in both radial artery and in the @entity439 were similar. Pressures in the @entity439 and in the parent vessels were similar. Peak and mean flow velocities in the parent arteries did not change significantly with @entity2647 infusion, nor did vessel diameters as measured angiographically.
