Risk of XXXX in @entity1 with post-traumatic cerebrospinal fluid leakage-Analysis of 1773 cases.

@entity1 @entity5745 @entity4767 @entity131 @entity542 @entity2972 @entity772 @entity1504 @entity5173 @entity5254 @entity204
BACKGROUND: Post-traumatic cerebrospinal fluid (CSF) leakage is one of the most troublesome conditions associated with @entity542 . CSF fistulae, @entity4767 , or even @entity204 may accompany it. Few studies have discussed post-traumatic @entity5173 as a risk factor in mortality following @entity542 . We conducted this cohort study to examine the issue. METHODS: We reviewed the records in the Taiwan @entity131 ( @entity131 ) Registry System between 1993 and 2008. The study group included @entity1 with acute @entity131 and post-traumatic @entity5173 , and the control group included cases with @entity131 but without @entity5173 , selected randomly at a 5:1 ratio with respect to the study group. The demographic data, Glasgow @entity772 Scale, brain computerized tomography, association of skull fractures and @entity1504 , and 1-year mortality rates between these two cohorts were reviewed meticulously and analyzed statistically. RESULTS: Of 174,236 cases, 1773 with post-traumatic @entity5173 were included in the study group, and 8865 cases in the control group. Of the total 10,638 sampled cases, 406 (3.8%) died during the 1-year follow-up period, 159 (9.0%) cases in the CSF leakages group, and 247 (2.8%) in the control group. The @entity1 with @entity5173 had a significantly higher mortality rate within 1 year (adjusted hazard ratio  =  1.44, p  <  0.001) than those without. We divided the @entity5173 group into three subgroups: @entity2972 (n  =  568), @entity5254 (n  =  302), and tension @entity5745 (n  =  903). The mortality rates were 8.5% (48/568) in the @entity2972 subgroup, 10.9% (33/302) in the @entity5254 subgroup, and 8.6% (78/903) in the tension @entity5745 subgroup. The cases with @entity5254 had a significantly higher mortality rate than the other two subgroups (p  <  0.05). All three subgroups had significantly higher mortality rates than the control group during the 1-year follow-up period (adjusted hazard ratios  =  2.29, 1.35, and 1.32 in the @entity5254 , tension @entity5745 , and @entity2972 subgroups, respectively). CONCLUSION: Post-traumatic CSF leakages had higher mortality rates than those without CSF leakages in @entity131 cases, and the cases with @entity5254 had worse outcomes compared with CSF leakages with @entity5745 or @entity2972 .
