Dose response chemopreventive potential of @entity9080 against @entity3653 induced mammary @entity105 in female XXXX .

@entity3653 @entity9080 @entity5 @entity16786 @entity2197 @entity106 @entity35 @entity105
UNASSIGNED: The present study aimed to investigate the dose response chemopreventive potential of @entity9080 ( @entity16786 ) against @entity3653 ( @entity106 ) induced mammary @entity105 in female @entity35 . @entity5 was induced by a single dose of @entity106 (25mg/ @entity35 ) injected subcutaneously near mammary gland. We observed reduced body weight and @entity5 , @entity5 incidence and @entity5 volume in @entity106 -induced @entity35 . We also observed decreased antioxidant status (SOD, CAT, GPX and @entity2197 ) and increased lipid peroxidation (TBARS and LOOH) in plasma and mammary tissues. Increased levels of CYP450, Cyt-b5 and decreased levels of phase II (GST and GR) biotransformation enzymes noticed in liver and mammary tissues of @entity106 -induced @entity35 . Further, increased levels of lipid profile (TC, TG, PL and FFA) and lipoprotein (LDL and VLDL) were noticed. Whereas, decreased level of HDL in plasma and decreased levels of PL and FFA in mammary tissue. Oral administration of @entity16786 different doses (10, 20 and 40mg/kgbw) inhibited the @entity5 incidence and restored levels of biochemical markers. Biochemical findings are supported by histopathological studies. These results suggested that @entity16786 at a dose of 20mg/kgbw significantly exert chemopreventive potential against @entity106 -induced mammary @entity105 .
