Recovery of Adrenal Function in @entity1 with Glucocorticoids Induced XXXX .

@entity1 @entity4545 @entity1887 @entity2339 @entity701
BACKGROUND: The Chronic use of glucocorticoids (GC) suppresses function of the @entity2339 and often results in @entity1887 (AI). The present study aimed to determine the recovery rate of adrenal function in @entity1 with secondary AI within 1-2 years and to assess the factors predictive of adrenal function recovery. METHODS: This was a retrospective observational study that enrolled @entity1 diagnosed with GC-induced secondary AI between 2007 and 2013. AI was defined by peak serum @entity701 levels <18  g/dL during a standard-dose short synacthen test (SST). A follow-up SST was performed after 1-2 years, and responders were defined as those with @entity4545 (ACTH)-stimulated peak serum @entity701 levels >=  18  g/dL. RESULTS: Of the total 34 @entity1 diagnosed with GC-induced secondary AI at first, 20 @entity1 (58.8%) recovered normal adrenal function by the time of the follow-up SST (median follow-up period: 16.5 months). Although the baseline serum ACTH and @entity701 levels at the first SST did not differ between responders and non-responders, the incremental @entity701 response during the first SST was higher in responders than that of non-responders (7.88 vs. 3.56, P < 0.01). Additionally, higher @entity701 increments during the first SST were an independent predictive factor of the adrenal function recovery (odds ratio 1.58, 95% confidence interval 1.02-2.46; P < 0.05). CONCLUSIONS: In the present study, adrenal function recovery was achieved frequently in @entity1 with GC-induced secondary AI within 1-2 years. Additionally, an incremental @entity701 response at the first SST may be an important predictive factor of adrenal function recovery.
