Inbreeding and homozygosity in XXXX survival.

@entity1 @entity5516 @entity0
Genome-wide association studies (GWASs) help to understand the effects of single nucleotide polymorphisms (SNPs) on @entity0 ( @entity0 ) progression and survival. We performed multiple analyses on data from a previously conducted GWAS for the influence of individual SNPs, @entity5516 ( @entity5516 ) and inbreeding on @entity0 survival. (I.) The association of individual SNPs indicated no differences in the proportions of homozygous individuals among short-time survivors (STSs) and long-time survivors (LTSs). (II.) The analysis revealed differences among the populations for the number of @entity5516 per @entity1 and the total and average length of @entity5516 per @entity1 and among LTSs and STSs for the number of @entity5516 per @entity1 . (III.) Common @entity5516 at particular genomic positions were nominally more frequent among LTSs than in STSs. Common @entity5516 showed significant evidence for natural selection (iHS, Tajima's D, Fay-Wu's H). Most regions could be linked to genes related to @entity0 progression or treatment. (IV.) Results were supported by a higher level of inbreeding among LTSs. Our results showed that an increased level of homozygosity may result in a preference of individuals during @entity0 treatment. Although common @entity5516 were short, variants within @entity5516 might favor survival of @entity0 and may function in a recessive manner.
