Expression of @entity12152 , @entity52217 and XXXX in the developing postnatal brain.

@entity12152 @entity70751 @entity12988 @entity70753 @entity52217 @entity18151 @entity35 @entity70752
The abundant expression of @entity18151 ( @entity18151 ) proteins in neurons, together with their modulatory function on G-protein-dependent neurotransmission, provides the basis for cellular adaptation to sensory inputs. To identify the molecular mechanism involved in the sensory experience-induced neural development, we performed a systematic survey of the localization of mRNAs encoding three subtypes of the RGSs ( @entity12152 , @entity52217 and @entity70751 ) in developing @entity35 brains by in situ hybridization through postnatal day 2 (P2), P10 and @entity12988 to adult. The most dramatic changes of expression patterns were observed in the discrete neuronal cell layers of the cerebral neocortex (for @entity70752 ), the hippocampus (for @entity70753 ), the thalamus (for @entity52217 ) and the cerebellum (for @entity12152 and 7). In the neocortex, @entity12152 mRNA was enriched in the superficial cortical plate at P2, in contrast to @entity52217 , which was enriched in more mature neurons of the deeper layer V and VI. In the hippocampus, the neuronal cell layer-specific expression pattern of @entity12152 developed from P2 to @entity12988 . @entity52217 expression was temporarily confined to the CA pyramidal cell layer and not detectable in the dentate gyrus at P10 and @entity12988 . Similarly, a high level of expression of @entity70751 was observed in the CA area, but not in the dentate gyrus at P2 and P10. In the cerebellum, the maturation of laminar expression patterns for the three RGSs correlated with neuronal maturation and synaptogenesis at @entity12988 . The most characteristic temporal pattern among the three RGSs was observed for @entity52217 mRNA, which was highly enriched in the thalamocortical regions. The peaks of @entity52217 expression were seen in the following regions with distinct onset and duration: the neocortex (from P2 onward), the hippocampus (P10 and @entity12988 ) and the thalamus (from @entity12988 onward). The divergent temporal and spatial expression of @entity18151 subtypes and their dynamic control in the cortex, the hippocampus and the thalamus suggest that the @entity18151 family could play multiple distinct roles in experience-dependent brain development.
