[Chemoembolization with degradable starch microspheres in XXXX ].

@entity1 @entity632 @entity96 @entity5 @entity1138 @entity236 @entity160 @entity158 @entity157 @entity99 @entity9854
A new method of chemoembolization with degradable starch microspheres (DSM) was used for @entity1 with @entity99 . DSM, 40-45 micron in diameter, which are degraded by serum amylase, temporarily obstruct arterial blood flow at the arteriolar capillary bed. Experimental studies have demonstrated that such occlusion enhances the regional uptake and reduces systemic exposure to simultaneously administered arterial anticancer drugs. Transcatheter chemoembolization with DSM was performed in 14 cases of @entity157 and 8 cases of metastatic @entity96 . @entity632 or @entity1138 mixed with @entity9854 was injected into the @entity1 with @entity157 or metastatic @entity96 , respectively, through the proper hepatic artery. The therapeutic effect of this chemoembolization was evaluated by the change in @entity5 size measured by angiography or computed tomography. In @entity157 , @entity5 regression of over 50% was observed in 5 of 14 patients. Elevated serum @entity160 level of more than 200 ng/ml was decreased in all 6 cases. In metastatic @entity96 , @entity5 regression of over 50% was observed in 4 of 8 cases. Although half of the @entity1 had transient @entity158 within 2 hours, no major side effects such as @entity236 and hepatotoxicity were observed. Our results suggest that chemoembolization with DSM can be effectively used in the treatment of @entity99 .
