Immunological study in primary XXXX .

@entity1 @entity404 @entity706 @entity2905 @entity6518 @entity4383 @entity7893 @entity9676
Primary @entity9676 is a rare congenital condition associated with @entity6518 . @entity7893 and @entity2905 secondary to this condition are frequent but infectious complications are not. So far few immunological studies have been made in these @entity1 . We report here the results of such a study carried out in two adolescents. Both @entity1 presented with a dramatic decrease in serum gammaglobulins, especially IgG and IgA, and in peripheral blood lymphocytes, especially @entity404 T helper cells. From a functional standpoint, the proliferative response to certain mitogens was reduced. A decrease in in vitro production of immunoglobulins by B lymphocytes may be due to a faulty T/B cell cooperation. Histological examination of duodenal biopsy specimens revealed a decreased number of intraepithelial lymphocytes. Colonoscopy revealed @entity4383 in the terminal ileum, confirmed by endoscopic biopsy. The role of these abnormalities in the development of infectious complications and @entity706 is underscored.
