Dosimetric comparison of intensity-modulated radiosurgery and helical tomotherapy for the treatment of multiple intracranial XXXX .

@entity499 @entity343 @entity3
The purpose of this study was to evaluate the dosimetry of single fraction, single-isocenter intensity-modulated radiosurgery (IMRS) plans for multiple intracranial @entity3 and to compare @entity499 ( @entity499 ). Ten treatment plans with 3-6 brain @entity3 treated with IMRS were re-planned with @entity499 . The mean number of lesions was 5 and mean @entity343 22 cm(3). The prescribed dose was 16-20 Gy. The mean V100% was similar for IMRS and @entity499 , and the mean conformity index was 1.4, mean Paddick confirmity index was 0.7, and mean MDPD was 1.1 for both. The mean gradient index was similar for both. The mean 50% _isodose volume was 179.2 cm(3) for IMRS and 277.0 cm(3) for @entity499 (p=0.01). The mean maximum doses to organs at risk were lower for IMRS except brainstem and right optic nerve. For brain, the integral dose was 5.1 and 6.8 Gy-kg (p<0.001) and mean dose 4.0 and 5.4 Gy (p<0.001) for IMRS and @entity499 , respectively. The mean treatment times were 23 (IMRS) and 41 ( @entity499 ) minutes. Conformity and homogeneity indices were equivalent and sparing of the organs at risk was clinically acceptable for both IMRS and @entity499 . Though the gradient index was similar for IMRS and @entity499 , the mean 50% isodose volume and integral dose to normal brain were lower for IMRS as was treatment time.
