The effect of immunonutrition on bacterial translocation, and intestinal villus atrophy in XXXX .

@entity1 @entity3883 @entity1160 @entity535 @entity2348 @entity194 @entity9539 @entity35 @entity369
BACKGROUND _ AIMS: Spontaneous @entity2348 due to increased bacterial translocation (BT) in @entity1 with @entity3883 result in significant morbidity and mortality. The present study evaluates the effects of enteral nutrition with immune enhancing feeds on BT and intestinal villus histopathology promoted @entity3883 . METHODS: Fifty male @entity35 -albino @entity35 weighing 250-300g were assigned into five equal groups of 10. Animals in Groups I, II, and III were fed with standard chow, those in Group IV were given @entity1160 1g/kg/day and the remaining 10 animals in Group V were fed with an @entity369 , @entity9539 , and RNA-supplemented enteral diet for (1g/kg/day @entity535 and 230 kcal/kg) 7 days preoperatively. Group I underwent sham operation and the remaining animals in all other groups underwent common bile duct ligation. After operation, Group I had standard chow, Groups II and IV had @entity1160 , Groups III and V had an @entity369 @entity9539 , and RNA-supplemented enteral diet for 7 days. All animals were sacrificed on the 8th postoperative day and evaluated both biochemically and histopathologically. Samples from blood, liver, mesenteric lymph nodes and spleen were cultured under aerobic conditions. RESULTS: Significantly less BT was observed in groups fed with an @entity369 , @entity9539 , and RNA-supplemented enteral diet or @entity1160 in pre-and postoperative periods as compared to others (P<0.001). Histologic evaluation also showed significant reduction in villus atrophy in these groups. CONCLUSIONS: Enteral immunonutrition using @entity1160 or @entity369 , @entity9539 , and RNA-supplemented enteral diet during both pre-and postoperative periods seems to reduce BT and decrease @entity194 in @entity35 with @entity3883 .
