Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced XXXX .

@entity12698 @entity1340 @entity3175 @entity2682 @entity5018 @entity51 @entity3795 @entity158 @entity1286 @entity35 @entity3352
BACKGROUND: It has recently been suggested that non-reflex behavioral readouts, such as burrowing, may be used to evaluate the efficacy of analgesics in rodent models of @entity158 . OBJECTIVE: To confirm whether intraplantar Complete Freund's Adjuvant ( @entity3795 )-induced @entity158 reliably results in @entity51 which can be ameliorated by clinically efficacious analgesics as previously suggested. METHODS: Uni- or bilateral intraplantar @entity3795 injections were performed in male @entity35 Han @entity35 . The time- and concentration-response of @entity51 and the ability of various analgesics to reinstate burrowing performance were studied. An anxiolytic was also tested to evaluate the motivational cue that drives this behavior. RESULTS: @entity51 were dependent on the concentration of @entity3795 injected, most pronounced 24h after @entity3795 injections and even more pronounced after bilateral compared with unilateral injections. @entity12698 and @entity5018 reversed @entity3795 -induced @entity51 whereas @entity3352 failed to significantly reinstate burrowing performance. @entity1286 and @entity1340 failed to reinstate burrowing performance, but sedation was observed in control @entity35 at doses thought to be efficacious. An antibody directed against the nerve growth factor significantly improved @entity3795 -induced @entity51 . Neither @entity2682 nor the anxiolytic @entity3175 reinstated burrowing performance and the opportunity to find shelter did not modify burrowing performance. CONCLUSION: Burrowing is an innate behavior reliably exhibited by @entity35 . It is suppressed in a model of @entity158 and differently reinstated by clinically efficacious analgesics that lack motor impairing side effects, but not an anxiolytic, suggesting that this assay is suitable for the assessment of analgesic efficacy of novel drugs.
