The coagulopathy in XXXX : comparison of cerebral versus peripheral measurements of haemostatic activation markers.

@entity1545 @entity1 @entity2002 @entity542 @entity6343 @entity772
@entity1545 is known to result in various degrees of disordered haemostasis. Moreover, the recently developed assays of molecular markers of haemostasis can give an accurate reflection of its activation in vivo. The aim of this study was to monitor the levels of prothrombin fraction 1 + 2 ( @entity6343 ), thrombin antithrombin complexes (TAT) and D-dimer on the admission of @entity1 to the ICU and up to the fourth day postinjury. Seventeen @entity1 with @entity542 (Glasgow @entity772 scale 12 or less) were studied at King Khalid University Hospital, Riyadh. Their ages ranged from 10 to 40 years (mean 26). Blood samples were collected from the internal jugular vein, peripheral vein and artery. The mean levels of TAT and @entity6343 in the internal jugular vein was significantly higher than in both peripheral venous and arterial blood on admission and 24 h later. Thereafter, the levels in the three locations dropped significantly, but remained elevated above controls. D-dimer levels were very markedly elevated to a similar extent in the three locations throughout the study period. The prothrombin time was significantly prolonged in the three locations in the first two days. Plasma @entity2002 levels dropped very significantly in the jugular vein, and increased to above reference values later. Protein S and factor VII showed a significant drop in the first two days and increased to normal range thereafter. Outcome was evaluated using the Glasgow Outcome Scale at 6 months postinjury. Haemostatic measurements could not predict good outcome (12 @entity1 ) or bad outcome (four deaths). It was concluded that haemostatic activation is a transient, but common phenomenon after @entity542 and is more prominent in cerebrovascular than in peripheral blood. The number of @entity1 studied is too small to allow reliable association to be drawn between haemostatic changes on admission and prediction of outcome.
