XXXX + T lymphocytes are recruited to neoplastic cervix.

@entity1 @entity308 @entity404 @entity5 @entity6349 @entity405 @entity3146
ToliicIV distinguish normal cervical lymphocyte populations from phenotypes recruited to the cervix in response to cervical @entity5 , lymphocytes were isolated from normal and neoplastic cervix. A portion of the cervical transformation zone was obtained from 19 @entity1 with pathologically confirmed @entity3146 and from 20 @entity1 with normal cervices undergoing hysterectomy for benign indications. Mononuclear cells were harvested from cervical tissue using a serial, multienzymatic digestion procedure and enriched by density gradient centrifugation. Isolated cell populations were stained with surface marker-specific monoclonal antibodies and analyzed by fluorescent activated cell sorter to determine the percentage of B cells, total T cells, @entity404 + T cells, @entity405 + T cells, and natural killer (NK) cells. The distribution of circulating peripheral blood lymphocyte phenotypes was similar for both @entity1 with @entity5 and normal controls. A marked disparity in the proportions of NK cells and T cells was demonstrated among lymphocyte phenotypes infiltrating the cervix. The percentage of @entity404 + T cells and NK cells was significantly depressed (P = 0.04, P = 0.03, respectively) in @entity6349 tissue as compared to normal cervical tissue. In contrast, the proportion of @entity405 + T cells was significantly increased in the @entity6349 tissue (P = 0.0001). Analysis of immunocompetent cells in the circulation appears to have little correlation with immunocytes present in the @entity6349 epithelium. The @entity308 in the proportion of @entity404 + T lymphocytes and NK cells at the cervical squamocolumnar junction reflects a local recruitment of @entity405 + T cells to the site of @entity5 in the cervix.
