Alterations in plasminogen activation correlate with XXXX grading in colorectal adenomas.

@entity5115 @entity2289 @entity1412 @entity14 @entity652 @entity1141
Proteases are important for neoplastic invasion but a specific role for the plasminogen activator system in the progression of @entity14 to @entity1412 remains unclear. Consecutive tissue cryosections of 51 @entity652 , 49 distant mucosa samples and five mucosa samples from control subjects were histopathologically analysed for @entity1141 grade and tissue type, urokinase plasminogen activator levels and @entity2289 ( @entity2289 ) using immunosorbent methods. Plasminogen activation and urokinase-mediated proteolytic activity levels were assessed using in situ zymography. Plasminogen activation and tissue-type activator levels were lower in @entity652 than in mucosae (P < 0.001). @entity2289 concentration and urokinase levels were higher in @entity652 than in mucosae (P < 0.001 and P < 0.001 respectively). In @entity652 , urokinase concentration increased in parallel with @entity2289 , but only the urokinase levels correlated with the @entity1141 grade (P < 0.01). Thus, the alterations in plasminogen activation correlated with @entity5115 grading. In the mucosa to @entity652 , a marked decrease in tissue-type plasminogen activator occurred. In @entity652 , this decrease was accompanied by a concomitant increase in urokinase and @entity2289 . The urokinase level only continued to rise in parallel with the @entity1141 grade. Resulting protease-antiprotease imbalance in high-grade @entity1141 may represent the phenotypic change associated with malignant transformation and invasive behaviour.
