XXXX , @entity3372 and their combination improve endothelial function in different tissues in a @entity19 model of @entity165 -induced @entity731 .

@entity3372 @entity323 @entity6970 @entity2627 @entity1369 @entity19 @entity409 @entity731 @entity9887 @entity16203 @entity65 @entity165
BACKGROUND AND PURPOSE: @entity323 correlates with @entity65 and its common risk factors due to the development of @entity409 . Positive effects on endothelial and erectile function have been described for substances inhibiting the renin-angiotensin-system. Here, we investigated in an @entity731 model, whether @entity9887 (angiotensin receptor blocker) and @entity3372 (angiotensin converting enzyme inhibitor) are equivalent or the combination of both is superior in improving endothelial function in the aorta and the corpus cavernosum and in reducing @entity731 . EXPERIMENTAL APPROACH: Wild-type (WT, C57/B6) and apolipoprotein-E-deficient ( @entity6970 (-/-) ) @entity19 were treated with a @entity165 -rich diet for 8 weeks. @entity6970 (-/-) @entity19 were supplemented with either @entity9887 (20 mg  kg(-1)   day(-1) ), @entity3372 (2.5 mg  kg(-1)   day(-1) ) or the combination thereof. KEY RESULTS: Systolic blood pressure significantly decreased in treatment groups (P < 0.001), with significantly smaller reduction under @entity3372 monotherapy (P < 0.05). Endothelial function (assessed by pharmacological stimulation of aortic rings and corpus cavernosum in organ bath chambers) was impaired in @entity6970 (-/-) @entity19 compared to WT animals, which was improved by all three treatments to a comparable extent (P < 0.05). @entity731 size in the ascending aorta and aortic sinus (P < 0.001), the amount of lipid @entity2627 in cavernosal and aortic tissue (P < 0.05) and free radical load ( @entity16203 -stain) (P < 0.05) were enhanced in untreated @entity6970 (-/-) @entity19 in comparison to WT animals and were significantly reduced by either treatment. In penile tissue, expression of eNOS could be restored by renin-angiotensin- @entity1369 system blockade. CONCLUSIONS AND IMPLICATIONS: @entity9887 and @entity3372 significantly improved endothelial function of aortic and cavernosal tissues in @entity6970 (-/-) via reduction of oxidative stress. Combination of both agents does not enhance beneficial effects significantly.
