Haplotypic analysis of the XXXX gene in relation to @entity453 .

@entity72545 @entity1 @entity72547 @entity15606 @entity3979 @entity453 @entity1495 @entity731 @entity72546
@entity1495 ( @entity1495 ) plays an important role in the pathogenesis of @entity731 , the pathology underlying the majority of @entity453 . We previously identified several polymorphisms in the gene encoding @entity1495 . In this study we tested the hypothesis that variation in the @entity1495 gene influences the development of @entity731 . Three common polymorphisms, i. @entity72545 , @entity72546 and @entity72547 , were analysed in 1510 white subjects undergoing coronary angiography. Analyses of individual polymorphisms showed that the frequencies of the C/T and T/T genotypes of the @entity15606 polymorphism were significantly higher in @entity1 with @entity3979 than in those with a normal angiogram. Logistic regression analyses indicated that individuals carrying the -1562T allele had an approx. 1.5-fold higher risk of developing @entity3979 (OR 1.49, 95% CI 1.039-2.144), which was equivalent to an over 30% reduction in risk of @entity3979 in individuals not carrying this allele (OR 0.670, 95% CI 0.467-0.963). The three polymorphisms studied were found to be in strong linkage disequilibrium. Haplotype analyses showed that the C-G-C haplotype (-1562C, +279Q and +6C) was associated with a protective effect against @entity731 . Individuals carrying this haplotype were at reduced risk of developing @entity3979 (OR 0.695, 95% CI 0.530.92). Furthermore, the C-G-C haplotype was associated with less severe @entity453 , i.e. carriers of this haplotype were at a lower risk of having @entity3979 in more than one coronary artery (OR 0.796, 95% CI 0.640.99). These data, together with the previous finding that the -1562T allele has a higher transcriptional activity than the -1562C allele, support the notion that genetic variation with an effect on @entity1495 expression influences the development and progression of @entity731 .
