Prognostic significance of the pN classification supplemented by body mass index for XXXX .

@entity1 @entity28 @entity1721 @entity260 @entity418 @entity1349
BACKGROUND: Body mass index (BMI) has been associated with the risk of @entity418 . But the influence of BMI on @entity260 and prognosis has always been controversial. METHODS: Between 2000 and 2007, 424 @entity1 with @entity1721 ( @entity1721 ) underwent R0 esophagectomy at our center without neoadjuvant therapy. We performed univariate and multivariate analyses to identify prognostic factors for survival. RESULTS: @entity1 were divided into three groups according to Asian-specific BMI cut-off value: underweight (n = 45), normal weight (n = 228), and overweight and @entity28 (n = 151). Mean follow-up time was 39 months. The five-year @entity1349 ( @entity1349 ) rate was 19%, 34%, and 42% for underweight, normal weight, and overweight and @entity28 , respectively (P < 0.001). The five-year disease-free survival (DFS) rate was 24%, 41%, and 74% for underweight, normal weight, and overweight and @entity28 , respectively (P < 0.001). Multivariate analysis showed that pT, pN, and BMI were independent prognostic factors for DFS and @entity1349 . The C-index to the combined model showed improved predictive ability when compared to the pN classification (0.779 vs. 0.734). CONCLUSION: Preoperative BMI was an independent prognostic factor for @entity1349 and DFS. The proposed new prognostic model with the pN classification supplemented by BMI might improve the ability to discriminate @entity1721 @entity1 ' outcome.
