[Curative effect of transtympanic perfusion of XXXX on unilateral M  ni  re's disease].

@entity1 @entity801 @entity1109 @entity5395 @entity392 @entity9468 @entity346
OBJECTIVE: To investigate the curative effect of transtympanic perfusion of @entity801 on unilateral M  ni  re's disease. METHODS: Twenty-three @entity1 with unilateral M  ni  re's disease, 14 males and 9 females, aged 24 - 61, all with vertigo, @entity1109 to different degrees, were treated with transtympanic perfusion of @entity801 via the tympanostomy tube, 12 mg @entity5395 hours and 5 times a day. Pure tone audiometry and caloric test were performed every day before treatment. When @entity346 was observed by Frenzel's glasses and the treated ear showed no response to caloric test, the treatment was ceased. After the treatment the @entity1 were followed up for 9 - 11 years (10.2 years on average). RESULTS: The average amount of @entity801 used was 216 mg. The treatment lasted for 1.5 to 5 days (3.6 days on average). @entity9468 disappeared in 21 @entity1 (91%) and remained unchanged in 2. Hearing was improved or remained unchanged in 17 @entity1 (73%) and became worse in 6. @entity392 decreased or disappeared in 15 @entity1 (66%), and increased in 2 @entity1 . Ear fullness sensation decreased or disappeared in 21 @entity1 (91%). and remained unchanged in 2. Twenty-one @entity1 were completely recovered and returned to work (91%). CONCLUSION: Relieving intractable vertigo and preserving hearing, transtympanic perfusion of @entity801 is effective on unilateral M  ni  re's disease.
