Evaluation and comparison of anticonvulsant activity of @entity9887 and XXXX in experimentally induced animal models of @entity302 .

@entity410 @entity19 @entity16 @entity1092 @entity9885 @entity302 @entity32973 @entity6191 @entity9887 @entity14207
BACKGROUND: @entity302 is one common @entity16 requiring newer targets and newer drugs for its efficient management. In the recent days brain renin angiotensin system has gained immense importance because of its involvement in @entity410 regulation. OBJECTIVE: To evaluate and compare antiepileptic activity of different doses @entity9885 and @entity9887 on @entity32973 and PTZ induced @entity410 models. MATERIALS AND METHODS: Swiss albino @entity19 weighing around 25-30g of either sex were divided into 6 groups: Control ( Distilled Water- 10ml/kg), Standard - @entity1092 (40mg/kg), O1 - @entity9885 (2.5mg/kg), O2 - @entity9885 (5mg/kg), T1 - @entity9887 (5mg/kg), T2 - @entity9887 (10mg/kg). After 1hour of administration of control , test and standard drugs (orally), @entity410 were induced by administering PTZ (70mg/kg - i.p.) in PTZ model. @entity410 latency was the parameter recorded. In @entity32973 model, suppression of tonic hind limb extension was taken as measure of efficacy. RESULT: The results were analysed by one-way-ANOVA followed by Bonferroni's multiple comparison test. In @entity32973 test, dose dependently @entity9885 and @entity9887 significantly reduced the duration of @entity6191 in comparison to control (p<0.05). T2 - 9 + 0.89secs significantly reduced the tonic hind limb extension compared to other test groups (p<0.05). The percentage inhibition of @entity410 was T2-44.3%, O2-28.2%, T1-17.5%, O1- 12.3% respectively. In PTZ test, dose dependently @entity9885 and @entity9887 produced significant increase in @entity410 latency (p<0.05). T2 - 206.6+9.83secs significantly increased @entity410 latency compared to other test groups (p<0.05). Percentage protection from @entity410 is T2-52.6%, O2- 45.13%, T1- 37.5%, O1- 38.4% respectively. CONCLUSION: @entity14207 antagonist, @entity9887 and @entity9885 in a dose dependent manner showed increase in antiepileptic activity. Temisartan at higher dose produced significant antiepileptic activity in comparison to @entity9885 .
