XXXX versus @entity2645 in painful @entity305 : a randomized, controlled trial.

@entity1 @entity2974 @entity305 @entity2645 @entity750 @entity158 @entity906 @entity1063
BACKGROUND: Tricyclic antidepressants (TCA) are often used in the treatment of painful @entity305 . @entity906 is a @entity750 and weak @entity1063 reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of @entity2974 . OBJECTIVE: To test if @entity906 would relieve painful @entity305 and compare its possible efficacy with that of the TCA @entity2645 . METHODS: The study design was randomized, double blind, and placebo controlled, with a three-way crossover. Forty @entity1 were assigned to one of the treatment sequences, and 29 completed all three study periods. The daily doses were @entity906 225 mg and @entity2645 150 mg. During the three treatment periods, each of 4 weeks' duration, @entity1 rated @entity158 paroxysms, constant @entity158 , and touch- and pressure-evoked @entity158 by use of 0- to 10-point numeric rating scales. RESULTS: The sum of the individual @entity158 scores during treatment week 4 was lower on @entity906 (80% of baseline score; p = 0.006) and @entity2645 (77%; p = 0.001) than on placebo (100%) and did not show any statistical difference between @entity906 and @entity2645 (p = 0.44). The individual @entity158 scores for @entity158 paroxysms, constant @entity158 , and pressure-evoked @entity158 showed a similar pattern, whereas touch-evoked @entity158 was uncommon and was not altered by any of the drugs. Numbers needed to treat to obtain one @entity1 with moderate or @entity158 relief were 5.2 for @entity906 and 2.7 for @entity2645 . CONCLUSION: @entity906 relieves @entity158 in @entity305 and may be as effective as @entity2645 .
