Effect of XXXX gene polymorphisms on risk of transitional cell carcinoma of the urinary bladder in Taiwan.

@entity1 @entity72905 @entity5 @entity1759 @entity1606 @entity3
UNASSIGNED: The @entity1606 ( @entity1606 ) of the urinary bladder involves etiological factors, such as ethnicity, the environment, genetics, and diet. Cluster of differentiation ( @entity1759 ), a well-known @entity5 marker, plays a crucial role in regulating @entity5 cell differentiation and @entity3 . This study investigated the effect of @entity1759 single nucleotide polymorphisms (SNPs) on @entity1606 risk and clinicopathological characteristics. Five SNPs of @entity1759 were analyzed through real-time polymerase chain reaction in 275 @entity1 with @entity1606 and 275 @entity1 without @entity5 . In this study, we observed that @entity1759 @entity72905 polymorphism carriers with the genotype of at least one G were associated with @entity1606 risk. Furthermore, @entity1606 @entity1 who carried at least one G allele at @entity1759 @entity72905 had a higher stage risk than did @entity1 carrying the wild-type allele (p   <   0.05). In addition, The AATAC or GACGC haplotype among the five @entity1759 sites was also associated with a reduced risk of @entity1606 . In conclusion, our results suggest that @entity1759 SNPs influence the risk of @entity1606 . @entity1 with @entity1759 @entity72905 variant genotypes (AG   +   GG) exhibited a higher risk of @entity1606 ; these @entity1 may possess chemoresistance to developing late-stage @entity1606 compared with those with the wild-type genotype. The @entity1759 @entity72905 SNP may predict poor prognosis in @entity1 with @entity1606 .
