Effects of early high-dose streptokinase intravenously on left ventricular function in acute XXXX .

@entity1 @entity583 @entity1188
One hundred seven @entity1 who recently had acute @entity583 were randomly assigned either to standard heparin therapy or to intravenous streptokinase within 5 hours after the onset of symptoms in 7 hospitals without catheterization facilities. In the third week, the @entity1 were referred to a university hospital, where the patency rate of the @entity1188 was studied by selective coronary arteriography and left ventricular function by radionuclide angiography. Fifty-five @entity1 received heparin and 52 streptokinase within a mean period of 190 minutes after the onset of symptoms. Seven @entity1 in the heparin group and 4 in the streptokinase group died in hospital. The patency rate of the @entity1188 was identical in both groups (69% in the heparin group vs 68% in the streptokinase group). Left ventricular ejection fraction was not statistically different (0.44 +/- 0.13 in the heparin group vs 0.45 +/- 0.12 in the streptokinase group). Left ventricular ejection fraction was significantly higher in @entity1 with a patent @entity1188 than in @entity1 with an obstructed @entity1188 (0.49 +/- 0.12 vs 0.41 +/- 0.15, p less than 0.01). In @entity1 with inferior wall @entity1188 , left ventricular ejection fraction was identical (0.50 +/- 0.10 in the heparin group vs 0.52 +/- 0.09, in the streptokinase group). In @entity1 with anterior wall @entity1188 , left ventricular ejection fraction was significantly higher in the streptokinase group than in heparin group (0.40 +/- 0.10 vs 0.33 +/- 0.09, p less than 0.05). Analysis of regional wall motion revealed that improvement occurred in the lateral wall of the left ventricle.(ABSTRACT TRUNCATED AT 250 WORDS)
