[Diffusion of XXXX in the lungs].

@entity1 @entity2890 @entity8911 @entity4509 @entity5153 @entity153 @entity581
The authors report their findings on @entity4509 concentrations in serum and in the lungs, its diffusion in the parenchyma of the lungs--evaluated from the ratio tissue/serum concentrations, and they also compare their results with those registered during a study on @entity8911 , @entity2890 and @entity5153 , designed according to the same protocol. Ten @entity1 with @entity153 who had to undergo chirurgical excision, received 5 IM injections at 12-hourly intervals. The dose administrated at each injection was 7.5 mg/kg. The assay of @entity4509 was realized by HPLC. Serum concentrations at the presumed peak (17 micrograms/ml) and 12 hours after that were somewhat lower than those reported by other authors. The mean tissue concentrations 2 h 20 min. after the last injection were 14,95 +/- 4,52 micrograms/g in the normal parenchyma, and 16,18 +/- 3,67 micrograms/g in the pathological parenchyma. The ratio concentrations in the tissues and in serum were comparable for both the normal and pathological parenchyma. Compared to @entity8911 , @entity2890 and @entity5153 , this study confirms the large distribution of the @entity581 in the lung parenchyma. The behaviour of @entity8911 and @entity2890 with regard to the pathological parenchyma is rather comparable; @entity5153 better penetrates into the normal parenchyma, and the diffusion of @entity4509 is parallel for both the normal and pathological tissues.
