Human leucocyte antigens and pediatric XXXX : diagnosis and prognosis.

@entity1 @entity5698 @entity409 @entity991 @entity49429 @entity792 @entity1533 @entity4107 @entity775
UNASSIGNED: An association of human @entity4107 alleles with autoimmune conditions is increasingly being used for diagnostic purposes. The aim of our study was to examine whether HLA class II alleles in pediatric-onset @entity409 (pAILD) may serve as diagnostic markers and if they correlate with clinical outcome parameters. @entity1533 alleles of 76 @entity1 with pAILD ( @entity775 [ @entity775 ], @entity792 [ @entity792 ], @entity991 [ @entity991 ]) and of 50 healthy blood donors as control group were analyzed retrospectively. Diagnosis of these @entity1 was confirmed by the @entity775 score including liver histology, which has been re-evaluated by a blinded liver pathologist, and by bile duct imaging, as appropriate. Our results showed significant association of @entity1533 *03 with @entity49429 and @entity792 with 82  % specificity for @entity775 . For pAILD (excluding @entity5698 ), @entity1533 *03 homozygosity had specificity of 98  %, whereas sensitivity is low. Remission in @entity1533 *03-positive @entity1 appears to be less likely. @entity1533 *13 is significantly associated with @entity991 and also with @entity49429 . CONCLUSION: @entity1533 alleles provide supportive information for diagnostic workup in @entity1 with @entity409 , but they were not suitable for differentiation within pAILD. Their prognostic value could be helpful but needs to be evaluated further. What is Known:     @entity1533 *03 is NOT associated with pediatric @entity775 in a previous national study.     In other studies, @entity1533 *03 is associated with @entity49429 .     @entity1533 *13 is associated with @entity991 .     @entity1533 *04 is described as protective for AILD. What is New:     @entity1533 four-digit typing for all alleles and for all subgroups of pAILD combined with re-assessment of liver histology     @entity1533 *03:01 is associated with pediatric @entity49429 and @entity792 .     @entity1533 *03:01 appears to be a prognostic marker.     @entity1533 *13:01 is associated with pediatric @entity49429 in mixed ethnicity cohort.     @entity1533 *04 does not show any protective effect for pAILD.
