Effect of radiation and radioprotection on small intestinal function in XXXX .

@entity235 @entity8503 @entity16 @entity33 @entity1953
Radiation with doses > 7.5 Gy damages the @entity235 intestinal mucosa, and pretreatment with @entity8503 reduces this damage. However, the effects of radiation and of @entity8503 on in vivo intestinal transport are unclear. Therefore, we determined @entity235 survival, intestinal transport, and mucosal histology following unilateral abdominal irradiation. Isoperistaltic ileostomies were prepared in 23 @entity235 under general anesthesia and aseptic conditions. After a three-week recovery period, animals were given either placebo or @entity8503 , 150 mg/kg intravenously, 30 min prior to 10 Gy @entity1953 -60 abdominal irradiation. Ileal transport and histology were determined in both groups before exposure and one, four, and seven days after irradiation. Seven-day survival was significantly improved by pretreatment with @entity8503 (91% vs 33%, P < 0.02). On day 4, both @entity33 and net intestinal absorption were significantly better (P < 0.05) after @entity8503 than after placebo. Thus, radiation-induced @entity16 is accompanied by a reduction in net ileal absorption of water and electrolytes in vivo. In addition, pretreatment with @entity8503 improves animal survival while reducing ileal damage and improving intestinal absorption.
