Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in XXXX albino @entity35 .

@entity15132 @entity417 @entity66 @entity739 @entity35 @entity9266
BACKGROUND: Paullinia pinnata is a medicinal plant used for the treatment of @entity66 , including @entity417 in @entity739 . AIM: This study was carried out to investigate the effect of increasing doses of the methanolic leaves extract of @entity15132 on hematological parameters in @entity35 . MATERIALS AND METHODS: Thirty-six male @entity35 albino @entity35 were grouped into six groups of six animals each. Five doses; 50,100, 200, 400 and 800 mg/kg body weight of the @entity15132 extract were administered separately to five groups. The sixth group served as a control and received only the vehicle (70% physiological saline: 30% @entity9266 [v/v]). Administration was done orally daily for 28 days at 24 h interval. On day 29, the animals were made inactive, blood was then collected from the heart and various hematological parameters were evaluated. STATISTICAL ANALYSIS: Analysis of variance was employed. RESULTS: The packed cell volume and red blood cell count increased significantly (P < 0.05) in the treatment groups except at 200 mg/kg dose. The hemoglobin concentration increased in all the treatment groups. The values for the neutrophils at 50, 100, 200 and 800 mg/kg doses were higher than that of the control. The white blood cell count increased significantly (P < 0.05) at 50 and 400 mg/kg doses compared to the control and exceeded the normal physiological range. CONCLUSION: The maximum tolerable dose is 200 mg/kg body weight of the methanolic leaves extract of @entity15132 and the extract has anti-anemic property with the ability to increase neutrophils count.
