Analysis of XXXX (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics.

@entity1 @entity2162 @entity70699 @entity565 @entity3045 @entity4022 @entity29448
UNASSIGNED: @entity2162 ( @entity2162 ) plays a crucial role in @entity565 pathophysiology by regulating, processes of the lung function, and clinical response to bronchodilators. The @entity70699 - @entity29448 polymorphism in the gene encoding b2 adrenergic receptor ( @entity2162 ) has been associated with receptor non-responsiveness after b2-agonist exposure. In the present study, we sought to evaluate the possible association of @entity29448 polymorphism with @entity565 susceptibility, pharmacogenetic response to @entity3045 , and varying degrees of disease severity. Three hundred ninety-eight clinically diagnosed @entity1 and 456 healthy controls were enrolled for the study. @entity1 were classified into severity classes according to Global Initiative for Asthma guidelines. To assess bronchodilator response, spirometry was performed before and 15  min after @entity3045 (200   g) delivery. Responders to @entity3045 were categorized if percentage reversibility was greater than or equal to 12  % in them, while those showing reversibility less than 12  % were classified as non-responders. Genotyping was carried out by ARMS-PCR technique. Statistical methods were applied to test for the significance of the results. In the present study, there was lack of significant association of polymorphism with disease susceptibility as well as with bronchodilator response. The polymorphism was not associated with mild and moderate @entity565 subtypes; however, there was a notable association with severe @entity565 subtype. In addition, the polymorphism was associated with severe @entity565 compared to subtypes of mild and moderate @entity565 combined. In a South Indian population, the @entity2162 Arg/ @entity4022 may not form a susceptible variant to develop @entity565 nor can be a standard predictive marker to bronchodilator response; nevertheless, the patterns in @entity565 severity can be predicted by analyzing this variant.
