Prognostic value of the preoperative immunological profile in XXXX with @entity463 .

@entity1 @entity404 @entity405 @entity1199 @entity463 @entity1349
BACKGROUND: Aim of our study was to determine the predictive impact of certain serum immunological markers on @entity1349 ( @entity1349 ) in @entity1 with @entity463 ( @entity463 ). METHODS: We assayed prospectively values of @entity1199 ( @entity1199 ), immunoglobulin G (IgG), C4, CD3+, @entity404 + and @entity405 + cells via flow cytometry, enzyme-linked immunosorbent assay (ELISA) and radial immunodiffusion in preoperative sera of adult @entity1 with de novo histologically confirmed supratentorial @entity463 . Kaplan-Meier method and Cox proportional hazards models were used to assess clinical, laboratory, and treatment prognostic factors for @entity1349 . RESULTS: Twenty-six consecutive @entity1 were identified with a mean age of 59.6 years. Median follow up was 12 months. Lower @entity1199 values (<7.97 pg/ml vs. >= 7.97 pg/ml, P = 0.029) und @entity404 + counts (<200 cells/ l vs. >= 200 cells/ l, P < 0.001) correlated significantly with a shorter @entity1349 . The independent prognostic relevance of @entity404 + counts was confirmed by the multivariate analysis (HR = 0.010, 95% CI 0.001-0.226, P = 0.011). Further independent prognostic factors for @entity1349 were type of resection (resection vs. biopsy) and administration of radiotherapy (yes/no). CONCLUSION: Preoperative values @entity1199 and @entity404 + cells in sera may carry a prognostic impact. Novel diagnostic models prior to histopathological confirmation may be used to predict prognosis of @entity1 with @entity463 . Future studies should investigate whether targeting immune factors, such as @entity404 + and @entity1199 , may improve the prognosis of @entity1 with @entity463 .
