Shared and discrepant susceptibility for carotid artery and aortic arch XXXX : A genetic association study.

@entity1 @entity40229 @entity64 @entity23662 @entity70681 @entity70682 @entity730 @entity729
UNASSIGNED: Genome-wide association studies (GWASs) have identified several risk loci for @entity729 . Four single-nucleotide polymorphisms (SNPs, @entity40229 , @entity23662 , @entity70681 and @entity70682 ) were associated with @entity729 with P values less than 5  *  10(-8) in GWASs. It is unclear if these associations exist in other vascular beds. Thus, we evaluated the impacts of these four SNPs on carotid artery and aortic arch @entity730 in this study. Computed tomography was applied to quantify the @entity729 and aortic arch. 860 @entity1 with @entity64 completed @entity730 quantification and genotype testing were included in data analysis. Each SNP was evaluated for the association with carotid @entity729 , and with aortic arch @entity730 using generalized linear model. Among the four tested SNPs, @entity70681 was associated with @entity730 in both carotid artery (b  =  0.31, 95% confidence interval [CI] 0.10-0.52, P  =  0.003) and aortic arch (b  =  0.32, 95% CI 0.10-0.54, P  =  0.004), while @entity23662 was only associated with carotid @entity729 (b  =  0.28, 95% CI 0.06-0.50, P  =  0.011). In gender-stratified analyses, @entity70681 had significant impacts on carotid artery (P  =  0.003) and aortic arch @entity730 (P  =  0.008) in male, but not in female @entity1 ; while @entity40229 was significantly associated with carotid @entity729 in female (P  =  0.013), but not in male @entity1 . In conclusion, SNPs associated with @entity729 may also increase the risk of @entity730 in other arteries such as carotid artery and aortic arch.
