Central nervous system involvement in nocturnal XXXX : evidence of general neuromotor delay and specific brainstem dysfunction.

@entity1 @entity11795 @entity427
PURPOSE: To assess the involvement of central nervous system factors in the etiology of childhood nocturnal @entity11795 , an ongoing study of the fine neurology and neurophysiology has been instituted. MATERIALS AND METHODS: A total of 22 @entity1 8 to 14 years old were subcategorized sporadic and familial groups. @entity1 underwent a number of examinations, including a complete family pedigree; blood samples for linkage analyses; pediatric examination; urinalysis; uroflowmetry with pelvic floor electromyography; 24-hour flow charts; parental micturition questionnaire; @entity1 behavior checklist; intelligence test; standardized @entity1 psychiatric interview; acoustic, visual and event related late evoked potentials; Zurich Neuromotor Test @entity427 . In this preliminary report only the results of the Zurich Neuromotor Test @entity427 are reported. RESULTS: In the Zurich Neuromotor Test Battery @entity1 with @entity11795 had a longer timed performance but did not have more associated movements than the controls. In the startle-blink modulation paradigm inhibition of the electromyograph amplitudes was greatest following prestimulation with an interval of 120 milliseconds. This inhibition is known to be reduced among @entity1 with @entity11795 compared to nonwetting @entity1 . The results indicated a general developmental (neuromotor) delay, in addition to specific dysfunction of the brain stem in @entity1 with @entity11795 . The pre-pulse inhibition, as well as inhibition of bladder emptying at sleep, are regulated by brainstem centers in close anatomical proximity to the pontine micturition center and by analogous mechanisms. CONCLUSIONS: Reduced pre-pulse inhibition may represent a genetically transmitted trait indicative of nocturnal @entity11795 .
