Association between inflammatory biomarkers and thin-cap XXXX detected by optical coherence tomography in @entity1 with coronary heart disease.

@entity1 @entity1187 @entity650 @entity951 @entity741 @entity299 @entity1856 @entity1851
INTRODUCTION: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND METHODS: This study included 47 @entity1 with @entity741 (22 @entity1 with @entity1187 and 25 @entity1 with @entity951 ) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity @entity1851 (hs-CRP) and @entity650 ( @entity650 ) were measured. The OCT can detect thin-cap @entity1856 (TCFA), a lesion with high potential for adverse @entity299 . We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers. RESULTS: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and @entity650 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and @entity650 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log @entity650 was an independent predictor for TCFA detected by OCT (log @entity650 , 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that @entity650 , compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). CONCLUSIONS: Peripheral blood levels of both hs-CRP and @entity650 were associated with TCFAs, as detected by OCT. Moreover, @entity650 has a higher potential than hs-CRP for predicting TCFA.
