Longitudinal magnetic resonance imaging study shows progressive pyramidal and XXXX in @entity7960 .

@entity7960 @entity1 @entity75 @entity854 @entity717 @entity62
INTRODUCTION: Spinal cord and peripheral nerves are classically known to be damaged in @entity7960 , but the extent of cerebral involvement in the disease and its progression over time are not yet characterized. The aim of this study was to evaluate @entity75 in @entity7960 METHODS: We enrolled 31 @entity1 and 40 controls, which were evaluated at baseline and after 1 and 2 years. To assess gray matter, we employed voxel-based morphometry and cortical thickness measurements. White matter was evaluated using diffusion tensor imaging. Statistical analyses were both cross-sectional and longitudinal (corrected for multiple comparisons). RESULTS: Group comparison between @entity1 and controls revealed widespread macrostructural differences at baseline: gray matter atrophy in the dentate nuclei, brainstem, and precentral gyri; and white matter atrophy in the cerebellum and superior cerebellar peduncles, brainstem, and periventricular areas. We did not identify any longitudinal volumetric change over time. There were extensive microstructural alterations, including superior cerebellar peduncles, corpus callosum, and pyramidal tracts. Longitudinal analyses identified progressive @entity854 at the corpus callosum, pyramidal tracts, and superior cerebellar peduncles after 1 year of follow-up. CONCLUSION: @entity1 with @entity7960 present more widespread gray and @entity62 than previously reported, including not only infratentorial areas, but also supratentorial structures. Furthermore, @entity1 with @entity7960 have progressive @entity854 amenable to detection in a short-term follow-up.    2015 International Parkinson and @entity717 Society.
