PP025. Measurement of the activity of the circulating and intrarenal XXXX -angiotensin system (iRAS) in pregnant and non-pregnant subjects.

@entity1 @entity8 @entity1289 @entity916 @entity1468 @entity1011 @entity4759
OBJECTIVES: To see if urinary angiotensinogen (uAGT)/ @entity1011 and other urinary components of the RAS could be used to detect @entity8 in pregnancy, as @entity8 predisposes to @entity1468 . METHODS: Plasma and urinary prorenin, @entity1289 and AGT (iRAS) were measured by ELISA. Urinary active @entity916 levels were measured enzymatically (9 males, 10 non pregnant, 61 Australian Indigenous pregnant @entity1 ). RESULTS: No relationships between plasma RAS and iRAS were found. In non-pregnant females plasma AGT levels were inversely related to protein and albumin/ @entity1011 (r=-0.72, P=0.019, n=10; r=-0.65, P=0.042, n=10). In pregnancy, plasma @entity1289 levels were related to protein/ @entity1011 (r=0.29, P=0.036, n=54). Urinary protein/ @entity1011 was not related to iRAS activity (males and non-pregnant females) but in pregnancy was related to prorenin and active @entity916 / @entity1011 (r=0.45, P=0.02, n=26 r=0.47, P<0.001, n=50). Urinary albumin/ @entity1011 was related to uAGT and active @entity916 / @entity1011 in pregnancy (r=0.39, P=0.005, n=51; r=0.37, P=0.008, n=51). uACE/ @entity1011 and uAGT/ @entity1011 were related (r=0.52, P<0.001, n=51). CONCLUSION: Excretion of components of the iRAS is independent of plasma levels. Not only is uAGT/ @entity1011 related to albumin/ @entity1011 but there are similar relationships with other iRAS components. Measurement of the iRAS in @entity1 pregnancy may detect early stage @entity8 , @entity4759 in Indigenous Australians.
