Predictors of non-invasive ventilation tolerance in XXXX .

@entity1 @entity303 @entity73 @entity1576 @entity746 @entity204
BACKGROUND: The most frequent cause of @entity204 in @entity1 with @entity746 ( @entity746 ) is @entity1576 . Recently, it has been shown that non-invasive ventilation improves survival and quality of life in @entity746 @entity1 with @entity1576 , but little is known about predictors of non-invasive ventilation adaptation and tolerance. In this study we evaluated the effect of a comprehensive information about non-invasive ventilation use and a prolonged and intensive monitoring on tolerance to this palliative care. METHODS: We prospectively monitored all consecutive @entity746 @entity1 with @entity1576 and indication to non-invasive ventilation between January 2005 and December 2007. Non-invasive ventilation adaptation was always performed in a hospital setting. RESULTS: Forty-four @entity1 were considered eligible: six declined the non-invasive ventilation proposal and one was excluded due to severe fronto-temporal @entity303 . Non-invasive ventilation was offered to thirty-seven inpatients in our @entity746 Centre, thirty-two of whom presented with severe (n=9) or mild-moderate (n=23) @entity73 at non-invasive ventilation initiation. The mean time interval for adaptation to ventilation was 5  2 days, but @entity1 remained in hospital for an average extended period of one week. Thirty-five of the 37 @entity1 who started non-invasive ventilation, including those with severe @entity73 , remained tolerant at twelve months follow-up. CONCLUSIONS: Our study shows that an intensive educational training and adaptation on non-invasive ventilation, when performed in a hospital multidisciplinary setting, increases compliance and tolerance over time, even in those @entity1 with severe @entity73 . However, the design of our study, mainly based on a continuous monitoring and educational training of the @entity1 , might not make it fully applicable to an outpatients setting.
