Prevention of microvascular complications in @entity6 XXXX and adolescents.

@entity1 @entity8 @entity101 @entity6 @entity3949 @entity177 @entity1723 @entity3650 @entity2412 @entity989
@entity6 causes profound alterations in many body tissues. Microvascular @entity6 complications include @entity3949 , @entity8 and @entity989 . @entity8 first becomes manifest with hyperfiltration and microalbuminuria. These functional changes evolve over several years to a stage of marked @entity177 . The possible preventive measures are metabolic control, reduction of dietary protein intake and use of ACE-inhibitors. Metabolic control is also important for the prevention of @entity6 . In fact, @entity1 with HbA1c higher than 10% have an increased risk of progression of @entity989 . Moreover, an accelerated progression of @entity989 has been observed in @entity1 with systemic @entity101 following the onset of microalbuminuria. It has been demonstrated that @entity3949 can also be present during childhood; therefore, it is possible to detect electrophysiological abnormalities in @entity1 and adolescents with @entity1723 . Glycaemic and blood pressure control are, so far, the main means for possible prevention or modification of the natural history of @entity2412 . Tight glycaemic control may have beneficial effects for @entity3949 . In addition, other preventive measures, such as @entity3650 reductase inhibitors, gangliosides, neurotrophic vitamins, etc., have been studied in the last years. However, no conclusive results have been obtained so far.
