Circulating regulatory T cells in @entity1 with severe @entity221 with XXXX .

@entity1 @entity404 @entity882 @entity221 @entity403 @entity2902 @entity166
UNASSIGNED: Background: Severe @entity221 with @entity882 (SFTS) is a newly emerging @entity166 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity1 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity404 +/total lymphocytes, @entity404 + @entity2902 +/ @entity404 + cells and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells was observed in @entity1 with SFTS compared with healthy controls. In contrast, the percentage of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in the @entity1 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity1 with SFTS at different stages. The results showed that the proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells in the non-severe group was prominently higher than that in @entity1 with severe SFTS. Conversely, the proportion of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity1 with SFTS. Our investigation suggested that the proportions of @entity404 +/total lymphocytes and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.
