[Virological, epidemiological and pathogenic aspects of XXXX polyomaviruses].

@entity1 @entity8 @entity1310 @entity8999 @entity198 @entity8315 @entity5 @entity281 @entity1800 @entity3832 @entity2335
VIROLOGICAL ASPECTS: @entity1 polyomaviruses ( @entity8999 and @entity8315 ), together with simian polyomaviruses (SV40 virus) share 75% of genomic homology. Their in vivo and in vitro genomes vary. Molecular analyses have identified several genotypes, some of which appear related to the development of @entity1800 . Genomic modifications of the regulation area might provide the @entity8999 with a pathogenic aspect thus enhancing the induction of tubulo-interstitial @entity8 in renal transplant recipients. EPIDEMIOLOGY: @entity1 polyomaviruses are ubiquitous and exhibit a sero-prevalence of 60 to 80% in adults. Following a @entity281 via the respiratory tract in childhood, these viruses are diffused in the blood using the B-lymphocytes during their latent stage in the urogenital tract. The reactivation that occurs after several years is asymptomatic and urinary excretion of @entity8999 is observed in 4 to 6% of immunocompetent @entity1 . PATHOGENIC POTENTIAL: @entity1 polyomaviruses have a cytopathogenic effect on the urothelium and epithelium of renal transplant recipients. Infection by @entity8999 may provoke @entity2335 or @entity3832 . The JCv is the cause of progressive multifocal leuko- @entity198 . The @entity8999 (and less frequently the JCv) is responsible for tubulo-interstitial @entity1310 possible leading to renal transplant loss. They also have an oncogenic effect and their implication in the origin of @entity5 is the subject of many studies.
