Chemotherapy of @entity7289 with high doses of XXXX or a single dose of @entity3070 : microfilaria levels and side effects.

@entity3070 @entity1 @entity6566 @entity390 @entity6567 @entity391 @entity1296 @entity10 @entity7289
Fifty adult male subjects with moderate to heavy @entity7289 from the Liberian rain forest were selected for a double-blind placebo-controlled chemotherapy study. The effects of high doses of @entity6566 ( @entity6567 ) - 30 mg/kg/d - over one week preceded by a one week initial treatment with normal oral doses of @entity6567 or @entity6567 lotion were compared with a single dose of @entity3070 (150 micrograms/kg) and placebo. During the initial treatment @entity6567 tablets or lotion caused distinctly more frequent and severe reactions than did invermectin. The reactions to @entity3070 did not differ from those of the placebo @entity1 . High doses of @entity6567 caused, in about half of the @entity1 , @entity10 , @entity1296 , @entity390 or @entity391 . @entity6567 markedly increased the number of corneal microfilariae and of corneal opacities compared to @entity3070 . All changes resolved with a return to pretreatment findings two months after treatment. The three treatment groups showed no differences at the ten months follow-up. In all treated @entity1 skin microfilaria counts fell almost to zero by the end of the two week therapy. In the @entity3070 group microfilaria counts remained significantly lower than in the @entity6567 @entity1 at the two and ten months examinations. In summary, @entity3070 was much better tolerated than @entity6567 and had a longer lasting effect on the microfilariae in the skin. Since high doses of @entity6567 were less effective and caused more frequent and severe side effects, this approach cannot be recommended for treatment of @entity7289 .
