Trypsin activity. A new marker of XXXX .

@entity1 @entity788 @entity167 @entity660 @entity8883 @entity71349
A normal serum amylase level is found in up to 32% of @entity1 with @entity8883 . This underlines the need for more sensitive diagnostic tests in this frequent cause of @entity788 . Animal and @entity1 studies have shown that chronic @entity167 consumption leads to important modifications in trypsinogen metabolism. The present work has prospectively analyzed admission serum trypsin activity with a new biochemical test and usual markers such as amylase, lipase, and immunoreactive trypsin in 32 attacks of acute @entity788 . Seventeen were due to @entity167 and 15 to other causes, including 11 with @entity788 . High trypsin activity (median: 235 units/liter; range: 165-853) was found in all @entity1 with @entity8883 even when the amylase level was normal on admission (3/17: 18%). Trypsin activity did not differ between nonalcoholic @entity788 (N = 15): 84 units/liter (42-98), alcoholic controls (N = 15): 77 units/liter (40-122), and healthy controls (N = 62): 81 units/liter (15-143). The difference was not related to the severity of disease or circulating @entity71349 , or immunoreactive trypsinogen levels. Lipase/amylase ratio was less discriminant than trypsin activity between alcoholic and nonalcoholic diseases. We conclude that serum trypsin activity seems specific to @entity8883 and should be included in new prospective studies assessing biochemical testing of @entity167 -related @entity660 .
