[The correlation of multidrug resistance phenotype with clinical response to chemotherapy in XXXX ].

@entity1 @entity1262 @entity5 @entity900 @entity7895 @entity7290 @entity74 @entity1487
OBJECTIVE: The correlation of multidrug resistance(MDR) phenotype with clinical response to chemotherapy was investigated in @entity1 with @entity5 . METHOD: Tumor specimens prior to neoadjuvant chemotherapy from 36 cases of @entity5 were collected for detection of @entity1262 ( @entity1262 ) with anti- @entity7895 monoclonal antibodies (JSB-I). Immunohistochemical assays were used for @entity1262 detection on 5 microns thick frozen section. Anti- @entity7895 monoclonal antibodies(JSB-I) as primary antibodies and goat anti-mouse IgG monoclonal antibodies as second antibodies were applied. All @entity1 received preoperative induction chemotherapy with a regimen of @entity900 , @entity1487 and @entity7290 . Evaluation for @entity5 response was scored as follows: Response to chemotherapy was graded as good for complete response or partial response; as poor for stable disease or @entity74 . RESULT: Of the 36 pretreatment specimens, 12(33.3%) were @entity1262 positive and 24 (66.7%) were @entity1262 negative. Among the 12 @entity1 with @entity1262 positive, 3(25%) had a good response and 9(75%) had a poor response. Of the 24 @entity1 with @entity1262 negative, 21(87.5%) had a good response and 3(12.5%) had a poor response (P < 0.05). CONCLUSION: These preliminary data suggest that a significant correlation between MDR phenotype, @entity7895 -mediated and chemotherapy resistance existed.
