Anergy-like immunosuppression in XXXX bearing pulmonary foreign-body granulomatous inflammation.

@entity738 @entity19 @entity4 @entity358 @entity56 @entity6401
@entity358 were induced in BALB/c @entity19 by the intratracheal injection of insoluble polymerized dextran and latex microparticles. Very large @entity738 developed around dextran beads, which reached peak intensity within 2-3 days and rapidly declined in size thereafter. Latex beads generated small stable lesions. The involvement of cell-mediated immunity could not be demonstrated in the inflammatory responses induced by either type of bead. Antigen-induced @entity56 ( @entity56 ) and mitogen-induced @entity56 -like footpad reactions were markedly suppressed in immunized @entity19 bearing early dextran @entity738 . Mitogen-induced @entity56 -like footpad reactions were suppressed in unimmunized animals bearing early dextran @entity6401 . Antigen- and mitogen-induced @entity4 recovered to normal levels as dextran @entity738 diminished in size. No suppression of these footpad reactions was observed in @entity19 bearing small latex @entity6401 . The intraperitoneal injection of aqueous extracts prepared from the lungs of unimmunized donor animals bearing early dextran @entity6401 could partially transfer suppression of mitogen @entity56 -like footpad responses to normal @entity19 . These results suggest that cells within large, nonimmunologic lung @entity738 produce a soluble factor which participates in the expression of anergy-like immunosuppression.
