Endotoxin, XXXX , and @entity13983 effects on the radiation-sensitized walker 256 @entity35 carcinosarcoma.

@entity39 @entity5 @entity1425 @entity1003 @entity35 @entity13983
A radiation exposure of 1500 R to the Walker 256 @entity35 @entity5 was found to sensitize this @entity5 to the effect of a sublethal dose of endotoxin (Sarratia marcescens lipopolysaccharide) given 2 days later so that complete or almost complete destruction of the @entity5 resulted. Histological. study showed rapidly developing massive @entity39 of @entity5 tissue. Tracer experiments with 131I-labeled antibody to @entity35 fibrin indicated an absence of blood circulation in the treated @entity5 . These results suggest that the lesion may be secondary to @entity1003 occurring in the vascular bed of the @entity5 . Apparently identical lesions were also produced by @entity1425 and @entity13983 , alone or in combination. It is known that even untreated @entity5 are often the site of fibrin deposition. Presumably radiation, by @entity5 cells, enhances the release of coagulation-producing substances into the vascular bed. It is postulated that the effect of subsequent treatment with the drugs listed above is produced by circulatory stasis induced in the @entity5 . This may be associated with Hageman factor activation or release of platelet factor 3.
