Mechanical thrombectomy with the Penumbra recanalization device in acute XXXX .

@entity1 @entity583 @entity64 @entity385
BACKGROUND AND PURPOSE: The aim of this study was to assess the clinical outcome of @entity1 treated with the Penumbra system (PS) for acute @entity385 . A retrospective, monocentric matched-pair analysis in comparison with @entity1 treated by intraarterial thrombolysis (IAT) with alteplase was designed for this purpose. METHODS: Twenty-two consecutive @entity1 , (mean age 62), with acute @entity385 and National Institutes of Health @entity64 Scale (NIHSS) scores >=  7 were treated with the PS. Twenty corresponding @entity1 could be identified, treated with IAT. Matches were sought for initial NIHSS score and target vessels. Thrombolysis in @entity583 (TIMI) grades, mortality rates, NIHSS upon discharge, and modified Rankin scores (mRs) at 90 days were compared. RESULTS: A total of 32 vessels in 20 @entity1 were treated in either arm of the study. Recanalization to TIMI 2/3 was successful in 25/32 (78%) of target vessels with the PS, and 17/32 (53%) of target vessels in the IAT group. Upon discharge, 2/20 @entity1 treated with PS and 7/20 @entity1 treated with IAT had a NIHSS score of 0 to 1 or an improvement greater or equal to 10-point on the NIHSS scale. All cause mortality at 90 days was 3/20 @entity1 treated with PS, and 2/20 @entity1 treated with IAT. Three out of twenty @entity1 treated with PS and 7/20 @entity1 treated with IAT had a mRS of  <= 2 at 90 days. CONCLUSION: The Penumbra system is effective in re-opening occluded major arteries. Our data seems to indicate that not all @entity1 benefit clinically from improved revascularization of occluded major arteries.
