Spontaneous changes in left ventricular function over the first 24 hours of XXXX : implications for evaluating early therapeutic interventions.

@entity1 @entity583 @entity1188 @entity662
The spontaneous changes in left ventricular ejection fraction (LVEF) during the first 24 hours of a first transmural @entity1188 were assessed in 34 @entity1 by serial gated cardiac blood pool imaging. Major therapeutic interventions with a view to limit @entity1188 size were not used. Four determinations of LVEF were performed. Study 1 was performed as soon as possible after admission to the hospital. Studies 2 and 3 were performed 2 and 4 hours, respectively, after study 1. Twenty-four @entity1 (70%) had study 1 within 6 hours after the onset of acute @entity662 and 10 had it 6-12 hours after the onset of @entity662 . Study 4 was performed 24 hours after the onset of @entity662 . Compared with study 1, 19 of 34 @entity1 (56%) had spontaneous changes in LVEF in at least one of the subsequent studies, exceeding the expected variability in stable @entity1 . The changes ranged from a 32% increase to 14% absolute decrease. LVEF improved in 11 @entity1 and deteriorated in eight. These spontaneous changes in left ventricular performance indicate that a single assessment of LVEF during the early hours of transmural @entity583 may not properly characterize cardiac performance in an individual @entity1 and may not be the most appropriate reference against which to compare subsequent evolution of left ventricular function. These data may have implications for studies of the effects of early therapeutic interventions on LVEF.
