Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of XXXX : A pilot study.

@entity1 @entity527 @entity3288 @entity7278
AIM: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on @entity3288 isolated from @entity527 from @entity7278 @entity1 . SETTINGS AND DESIGN: Written informed consent was obtained from each subject enrolled in the study. The Institutional Ethics Committee granted the ethical clearance for the study. MATERIALS AND METHODS: This study included 20 @entity1 diagnosed with @entity7278 . Pooled @entity527 samples were collected using sterile curettes from the deepest sites of periodontal pockets. The collected samples were then transported in 1 mL of reduced transport fluid. The organisms were cultured and confirmed. These organisms were then used for minimum inhibitory concentration (MIC) procedure. STATISTICAL ANALYSIS: Mean of the MIC value obtained was calculated. RESULTS: Thirteen out of the 20 clinical samples were tested that showed sensitivity at various concentrations. Five samples showed sensitivity at all concentrations. Twelve samples showed sensitivity at 8 mcg/ml. Eleven samples showed sensitivity at 4 mcg/ml, 8 samples showed sensitivity at 2 mcg/ml, and 5 samples showed sensitivity even at 1 mcg/ml. Mean MIC value of G. lucidum spore powder for @entity3288 obtained was 3.62 mcg/ml. CONCLUSION: G. lucidum with its multipotential bioactivity could be used as an anti-microbial, in conjunction with conventional therapy in periodontal disease.
