Screening for XXXX in a high-risk cohort: an eight-year experience.

@entity1 @entity788 @entity5409 @entity5 @entity660 @entity854
BACKGROUND: @entity788 is the fourth leading cause of @entity5 . METHODS: A prospective cohort study was undertaken between 2003 and 2011 at a tertiary care centre in Toronto, Canada. Two hundred and sixty-two subjects were enrolled based on an elevated estimated lifetime risk for @entity788 due to known genetic mutations and/or @entity5 family history. Subjects underwent annual magnetic resonance imaging, followed by additional investigations if abnormal findings were detected. Evidence of @entity5 or suspicious @entity854 prompted referral for surgical intervention. RESULTS: Average length of follow-up was 4.2 years, during which 84/262 (32%) subjects demonstrated @entity660 . Three @entity1 developed pancreatic adenocarcinoma (one 1.5-cm tumor was resected but recurred, while the other two subjects developed @entity5 ), and a fourth @entity1 developed a @entity788 that was resected. Fifteen subjects had radiologic evidence of branch-duct intraductal papillary mucinous @entity5 , of which two underwent surgical resection. Sixty-five subjects had simple pancreatic cysts that have remained stable. CONCLUSION: Magnetic resonance imaging can detect small @entity788 and @entity5409 , but further improvement in sensitivity is needed. An understanding of the natural history of pre-invasive lesions in members of high-risk families is necessary for developing a more effective screening program.
