Evidence for a Shared Etiological Mechanism of Psychotic Symptoms and @entity3119 in @entity1 with XXXX and Their Siblings.

@entity1 @entity3119 @entity716 @entity914
UNASSIGNED: The prevalence of @entity3119 in subjects with @entity914 is much higher than in the general population. The higher than chance co-occurrence has also been demonstrated at the level of subclinical expression of both phenotypes. Both extended phenotypes have been shown to cluster in families. However, little is known about the origins of their elevated co-occurrence. In the present study, evidence for a shared etiological mechanism was investigated in 3 samples with decreasing levels of @entity716 liability: 987 @entity1 , 973 of their unaffected siblings and 566 healthy controls. The association between the obsessive-compulsive phenotype and the @entity716 phenotype c.q. @entity716 liability was investigated. First, the association was assessed between (subclinical) @entity3119 and @entity716 liability. Second, in a cross-sib cross-trait analysis, it was examined whether (subclinical) @entity3119 in the @entity1 were associated with (subclinical) @entity716 in the related unaffected sibling. Evidence was found for both associations, which is compatible with a partially shared etiological pathway underlying @entity3119 . This is the first study that used a cross-sib cross-trait design in @entity1 and unaffected siblings, thus circumventing confounding by disease-related factors present in clinical samples.
