Increase of @entity404 + @entity2902 + regulatory T-cells in the liver of XXXX with @entity157 .

@entity1 @entity404 @entity5 @entity403 @entity2902 @entity157 @entity405
BACKGROUND/AIMS: The immune response to @entity5 -specific antigens is typically unable to control the growth and spread of malignant cells. Accumulating evidence indicates that the suppressive effects of @entity404 + @entity2902 + regulatory T-cells are at least partially responsible for the failure of immune-mediated elimination of @entity5 cells. METHODS: We have studied 25 @entity1 with @entity157 ( @entity157 ). The liver tissues with @entity157 were separated into the marginal region of @entity5 (peri- @entity5 region) and the non- @entity5 region distant from the @entity5 . @entity404 + @entity2902 + T-cells were quantified in the blood and the liver by flow cytometry and immunohistochemistry, and their effect on T-cell proliferation and activation was determined. RESULTS: We found a significant increase in both the proportion and absolute numbers of @entity404 + @entity2902 + T-cells in the peri- @entity5 regions, but not in unaffected areas (9.5 +/- 4.5 vs. 4.6 +/- 2.8%, P = 0.011). @entity404 + @entity2902 + T-cells isolated from peri- @entity5 regions displayed phenotype markers characteristic of regulatory T-cells, and expressed @entity403 mRNA. @entity405 + T-cells in peri- @entity5 regions were inversely proportional to @entity404 + @entity2902 + T-cells in the same region (P < 0.001). Moreover, isolated @entity404 + @entity2902 + T-cells inhibited autologous @entity405 + T-cell proliferation. CONCLUSIONS: Our results suggest that @entity404 + @entity2902 + T-cells in the marginal region of @entity157 may play a critical role in controlling @entity405 + cytotoxic T-cell activity and, thereby, contribute to the progression of @entity157 .
