Carotid plaque and candidate genes related to XXXX and endothelial function in Hispanics from northern Manhattan.

@entity1 @entity32 @entity4725 @entity2939 @entity310 @entity377 @entity16348 @entity8274 @entity10497 @entity1192 @entity5601 @entity3623 @entity731 @entity12974
BACKGROUND AND PURPOSE: The genetic influence on carotid @entity731 plaque is mostly unknown. This study examines the association between carotid plaque and single @entity377 polymorphisms in selected genes implicated in @entity32 and endothelial function. METHODS: A total of 43 genes (197 single @entity377 polymorphisms) involved in @entity32 and endothelial function were interrogated in 287 Dominicans from the Northern Manhattan Study (mean age, 64  7 years; 58% @entity1 ) who had undergone high-resolution B-mode ultrasound for examination of carotid plaque. Using an additive genetic model, multiple logistic regression analyses were conducted, a within-gene haplotype analysis was performed, and interactions between genes were examined. Results were validated in an independent set of 301 Dominicans. RESULTS: Carotid plaque was present in 143 (47%) @entity1 . Nine genes had at least 1 single @entity377 polymorphism associated (P <=0.01) with carotid plaque phenotypes: @entity310 , @entity3623 , @entity10497 , @entity16348 , @entity5601 , @entity1192 , @entity2939 , @entity12974 , and @entity8274 . Single @entity377 polymorphisms in @entity16348 , @entity5601 , @entity2939 , @entity12974 , and @entity8274 were also implicated with the same carotid phenotype in the validation analysis. Haplotype analysis revealed an additional gene of interest, @entity4725 . CONCLUSIONS: We report novel associations between variations in 10 genes involved in @entity32 and endothelial function and carotid plaque phenotypes in a Dominican sample, with replication for 5 genes in an independent Dominican sample.
