Strongyloides ratti: the role of XXXX in protection against tissue migrating larvae and intestinal adult worms.

@entity19 @entity281 @entity59
To determine the role of @entity59 ( @entity59 ) and eosinophils in protection against Strongyloides ratti, @entity19 treated with anti- @entity59 monoclonal antibody (mAb) were infected with S. ratti larvae. Strongyloides ratti egg numbers in faeces (EPG) in mAb treated @entity19 were higher than those in control @entity19 on days 6 and 7 after inoculation. The numbers of migrating worms in mAb treated @entity19 36 h after inoculation were higher than those observed in control @entity19 . Intestinal worm numbers in mAb treated @entity19 5 days after inoculation were higher than those in control @entity19 . These results show that eosinophils effectively protected the host against S. ratti infection by mainly the larval stage in primary @entity281 . The involvement of eosinophils in protection against secondary infection was also examined. Before secondary infection, @entity19 were treated with anti- @entity59 mAb and infected with S. ratti. Patent @entity281 were not observed in either mAb treated or control Ab treated @entity19 . The numbers of migrating worms in the head and lungs of mAb treated @entity19 increased to 60% of that in primary infected @entity19 . Intestinal worms were not found in mAb treated @entity19 or in control @entity19 after oral implantation of adult worms. Eosinophils were therefore mainly involved in protection against tissue migrating worms in secondary @entity281 .
