XXXX reduces repetitive action potential firing in spinal cord nerve cell cultures.

@entity1026 @entity19 @entity3393 @entity2915 @entity1772
(1) The anticonvulsant effects of @entity3393 were examined and compared with those of @entity1772 in monolayer primary cultures of @entity19 nerve cells using conventional intracellular recordings. (2) @entity3393 and @entity1772 (each 10-100 microM) decreased spontaneous synaptic activity when action potential frequencies exceeded 6 Hz. Neurons firing action potentials at frequencies below 6 Hz (about 90% of all impaled cells), however, were not affected by the drugs. (3) @entity3393 reduced the duration of @entity1026 -elicited bursts and the firing rate of action potentials within a burst. In contrast, @entity1772 lowered the frequency of the bursts without reducing intra-burst firing. The duration of the bursts was increased. (4) @entity3393 , but not @entity1772 , reduced the extent of sustained repetitive firing evoked by pulses of depolarizing current. (5) In the presence of @entity3393 , the second of two electrically evoked action potentials increasingly failed to appear as the intervals between successive stimulating pulses were shortened. Such an effect was not seen when @entity1772 was applied. Thus, both antispastic agents, @entity3393 and @entity1772 , reduce @entity2915 of spinal cord neurons in culture, although their mechanisms of action are different.
