Prospective study of endogenous sex hormones and fatal XXXX in postmenopausal @entity1 .

@entity1 @entity251 @entity2931 @entity53 @entity3800 @entity7042 @entity299 @entity204 @entity2671 @entity65
OBJECTIVES: To examine the association between @entity2671 , total and bioavailable @entity251 , @entity7042 , and total and bioavailable @entity53 concentrations and the risk of @entity204 from cardiovascular and @entity299 . DESIGN: 19 year old population based prospective study with 99.9% follow up. SETTING: Rancho Bernardo, California. SUBJECTS: 651 postmenopausal @entity1 , none taking @entity2931 . MAIN OUTCOME MEASURES: Concentrations of plasma sex hormones measured by radioimmunoassay in an endocrinology research laboratory. Cardiovascular and @entity299 deaths assessed by @entity204 certificate; 85% of 30% sample validated by record review. RESULTS: Age adjusted concentrations of sex hormones did not differ significantly in @entity1 with and without a history of @entity299 at baseline and did not predict @entity65 or @entity204 from @entity299 . Most 95% confidence intervals for the age adjusted relative risk of @entity65 or @entity204 from @entity299 were narrow, and all included one. Endogenous @entity2931 concentrations were not associated with significantly more favourable risk factors for @entity299 , and @entity251 was not associated with less favourable risk factors. CONCLUSION: These prospective data do not support a causal or preventive role for endogenous @entity2931 or @entity3800 and cardiovascular mortality in older @entity1 .
