Randomized trial of oral @entity396 treatment for cervical ripening before tandem application in cervix XXXX .

@entity1 @entity548 @entity3480 @entity5 @entity396 @entity158
PURPOSE: To investigate the efficacy of oral @entity396 administered to facilitate tandem application to the cervix as a part of brachytherapy in @entity1 with @entity5 . METHODS AND MATERIALS: Eighty @entity1 with @entity5 who had been planned to undergo brachytherapy at Dr. L  tfi K  rdar Kartal Training and Research Hospital were evaluated in a double-blind, prospective, randomized trial. @entity1 were divided randomly into two groups of 40 @entity1 . The first and second groups received 400  g of @entity396 orally and placebo, respectively, 3 h before tandem application. The two groups were compared in terms of age, diameter of @entity5 , parity, age at first intercourse, amount of @entity548 and @entity158 at first tandem application, length of endometrial cavity measured by hysterometer, and size of Hegar dilators used for cervical dilatation. RESULTS: Of all cases, 63.6%, 16.3%, 10%, 6.3%, 2.5%, and 1.3% were Stage IIB, IIIB, IIIA, @entity3480 , IIA and IIC, respectively. Mean (  SD) age (range) was 49.3    13.1 (25-83) years and 56.6    13.2 (30-78) years in the study and control groups, respectively (p = 0.015). Age at first intercourse, diameter of @entity5 , parity, amount of @entity548 at first tandem application, and length of endometrial cavity measured by hysterometer were not significantly different between the two groups. @entity158 score was significantly higher in the control group (p < 0.001). Application was significantly easier in the study group compared with controls (p < 0.001). Average size of initial Hegar dilators used for cervical dilatation was significantly higher in the study group compared with controls (p = 0.017). CONCLUSION: Administration of @entity396 400  g orally for cervical ripening before tandem application facilitates the procedure, increases @entity1 tolerability and comfort, and may decrease complication rates.
