The response of elderly veterans to daily XXXX supplementation of 2,000 IU: a pilot efficacy study.

@entity1 @entity3875 @entity460 @entity14257
OBJECTIVES: To determine the prevalence of hypovitaminosis D (serum @entity14257 <32 ng/mL; HVD) in a population of elderly veterans and conduct a preliminary assessment of the efficacy of supplementation with @entity3875 in correcting HVD. DESIGN: Randomized, double-blind, placebo-controlled clinical trial. SETTING: Geriatric clinic at the Bruce W. Carter Veterans Affairs Medical Center, Miami, Florida. @entity1 : Veterans aged 70 and older. INTERVENTION: Oral @entity3875 2,000 IU daily or placebo for 6 months. MEASUREMENTS: Serum @entity460 , @entity14257 , parathyroid hormone, and 24-hour urinary @entity460 . RESULTS: Of the 34 @entity1 who completed the study, 62% had HVD at baseline. In the treatment group, mean serum @entity14257 level rose from 28.4  7.9 ng/mL at baseline to 42.7  10.5 ng/mL at the end of the trial, but levels remained less than 32 ng/mL in three of 17 (18%) of the @entity1 . In the placebo group, the baseline level of 27.7  8.3 ng/mL remained unchanged (28.8  8.7 ng/mL). Supplementation did not alter serum or urinary @entity460 levels and did not result in any adverse events. CONCLUSION: These initial observations suggest that, in older veterans, @entity3875 2,000 IU daily for 6 months is generally safe and corrects HVD in most but not all individuals.
