Role of @entity3624 oxidase and leukocytes in postburn XXXX .

@entity5335 @entity2332 @entity3624 @entity26 @entity299 @entity551 @entity208 @entity5309 @entity5713 @entity460 @entity12609 @entity35 @entity224 @entity1168 @entity130
BACKGROUND: Recent studies suggest that the @entity299 that occurs after a major burn is mediated by @entity26 -derived free radicals. This hypothesis is based on the fact that @entity224 dismutase and @entity12609 , given with fluid resuscitation from @entity130 , provided significant cardioprotection. STUDY DESIGN: In this present study, @entity35 received either enteral @entity208 or @entity5335 -enriched diets to determine if @entity3624 oxidase mediates postburn defects in @entity299 and relaxation. @entity5309 ( @entity5309 ) were depleted to examine the contribution of @entity5309 -derived factors to postburn @entity299 . @entity35 were divided into eight groups: groups 1 to 6 received regular chow, and groups 7 and 8 received @entity5335 -enriched diets for 14 days before study. Groups 2, 4, 6, and 8 were given a third-degree burn comprising 43 +/- 2 percent total body surface area and were resuscitated with Ringer's lactated solution for 24 hours (4 mL/kg/percent burn). In group 2, burned @entity35 received fluid resuscitation alone; in group 4 (n = 10), @entity35 were given @entity208 , 10 mg/kg daily by gastric lavage for five days preburn, group 6 (n = 11) received @entity5713 (0.75 mg/kg) four days preburn, and group 8 (n = 11) received @entity5335 -enriched diets for 14 days before burn; sham burn controls included vehicle-treated (n = 10), @entity208 -treated (n = 8), @entity5309 -depleted (n = 8), and @entity5335 -fed @entity35 (n = 11) (groups 1, 3, 5, and 7, respectively). RESULTS: @entity130 produced mild @entity551 , @entity2332 , @entity1168 , and a significant decrease in left ventricular performance, despite aggressive fluid resuscitation (group 2). @entity208 , @entity5335 -enriched diets, and @entity5309 depletion partially attenuated burn-induced @entity299 and improved left ventricular responsiveness to increases in preload, coronary flow rate and exogenous @entity460 . CONCLUSIONS: Our data suggest that @entity3624 oxidase-derived @entity26 metabolites and @entity5309 -derived mediators contribute to postburn @entity299 .
