The effect of stress doses of @entity701 during XXXX on @entity1005 and health-related quality of life in survivors.

@entity1 @entity701 @entity1005 @entity326
OBJECTIVES: The exposure to intense physical and psychological stress during intensive care can result in @entity1005 ( @entity1005 ) in survivors. @entity701 is a biological stress mediator that can have a protective effect during severe stress. The administration of stress doses of @entity701 during treatment in the intensive care unit could theoretically result in a lower incidence of @entity1005 . We tested this hypothesis in survivors of @entity326 . DESIGN: A retrospective case-controlled analysis. SETTING: A 20-bed multidisciplinary intensive care unit of a tertiary-care university hospital. @entity1 : We identified 27 @entity1 who received standard therapy for @entity326 . These @entity1 served as controls and were compared with an equal number of @entity1 who received @entity701 in addition to standard treatment. These @entity1 were selected from our database with regard to age (+/-4 yrs), gender, and cause of @entity326 to be as similar as possible with control @entity1 . INTERVENTIONS: @entity1 from the @entity701 group had received stress doses of @entity701 (100 mg bolus, followed by 0.18 mg/kg/hr) in addition to standard treatment. @entity1 from the control group received standard protocol-driven treatment only. @entity1005 was diagnosed with the Posttraumatic Stress Syndrome-10 inventory, a self-report scale for diagnosis of @entity1005 . Health-related quality of life was measured using the Medical Outcomes Study Short-Form Survey (Medical Outcomes Trust, Boston, MA), which consists of 36 questions. MEASUREMENTS AND MAIN RESULTS: @entity1 who received @entity701 during @entity326 had a significantly lower incidence of @entity1005 than @entity1 who received standard treatment only (5 of 27 vs. 16 of 27; p = .01) and had significantly higher scores on the mental health index of the Medical Outcomes Study Short-Form health-related quality-of-life questionnaire (68 vs. 44 points; p = .009). CONCLUSIONS: Data from this study support the hypothesis that the administration of stress doses of @entity701 in doses equivalent to the maximal endocrine secretion rate during @entity326 reduces the incidence of @entity1005 and improves emotional well-being in survivors. This hypothesis should be tested in a prospective randomized trial.
