XXXX and @entity308 are associated with increased counts and degranulation of duodenal mast cells in @entity2210 .

@entity1 @entity308 @entity458 @entity4053 @entity11979 @entity148 @entity158 @entity2210
BACKGROUND: @entity1 with @entity2210 ( @entity2210 ) have increased risks for @entity458 than healthy @entity1 . This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of @entity2210 . MATERIAL AND METHODS: We prospectively included 48 @entity2210 @entity1 and 21 age- and sex-match healthy volunteers. There were 23 @entity1 with @entity4053 ( @entity4053 ) and 25 @entity1 with @entity158 ( @entity158 ). The @entity308 Scale (HADS) was administered to evaluate their psychosocial status. Upper endoscopy was performed with biopsy of the mucosa from the bulb of duodenum. Mast cells counts and degranulation rates were identified by @entity11979 staining. The relationship among the scores of HADS-A ( @entity148 ) and HADS-D ( @entity308 ) and the mast cell counts and degranulation rates were analyzed. RESULTS: The scores of HADS-A and HADS-D were significantly higher in @entity4053 and @entity158 @entity1 than the normal controls (P<0.05). The mast cell counts and degranulation rates in the duodenum were significantly increased in @entity4053 and @entity158 @entity1 than the controls (P<0.05). In either @entity4053 or @entity158 @entity1 , the HADS-A and HADS-D scores were positively correlated with the mast cell counts and degranulation rate. CONCLUSION: @entity2210 @entity1 had significantly higher risks for @entity148 and @entity308 , which may lead to @entity2210 through the increased mast cell counts and degranulation.
