Structural brain alterations in hemifacial XXXX : A voxel-based morphometry and diffusion tensor imaging study.

@entity1 @entity797 @entity2473 @entity1893 @entity717 @entity1649
OBJECTIVE: @entity1649 ( @entity1649 ) is characterized by involuntary, irregular clonic or tonic movement of muscles innervated by the facial nerve. We evaluated structural reorganization in brain gray matter and white matter and whether neuroplasticity is linked to clinical features in @entity1649 @entity1 . METHODS: High-resolution structural magnetic resonance imaging and diffusion tensor imaging data were acquired by 3.0T MRI from 42 @entity1 with @entity1649 and 30 healthy subjects. The severity of the @entity2473 was assessed according to @entity717 rating scale. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis were performed to identify regional grey matter volume (GMV) changes and whole-brain microstructural integrity disruption measured by fractional anisotropy (FA), @entity1893 ( @entity1893 ), axial diffusivity (AD) and radial diffusivity (RD). RESULTS: The VBM analysis showed that @entity1 with @entity1649 reduced GMV in the right inferior parietal lobule and increased GMV in the cerebellar lobule @entity797 , when compared with healthy subjects. Furthermore, within the @entity1649 disease group, GMV decreased with the disease duration in the right inferior parietal lobule. TBSS did not identify group differences in diffusivity parameters. CONCLUSIONS: While no white matter integrity disruption was detected in the brain of @entity1 with @entity1649 , our study identified evident GMV changes in brain areas which were known to be involved in motor control. SIGNIFICANCE: Our results suggest that @entity1649 , a chronic neurovascular conflict disease, is related to structural reorganization in the brain.
