[Comparative effects of inhalation anesthetics on XXXX with and without @entity460 entry blockers].

@entity101 @entity1508 @entity713 @entity1855 @entity235 @entity26 @entity594 @entity3652 @entity591 @entity3988 @entity460 @entity2614 @entity3810 @entity5161 @entity4488
@entity460 entry blockers have been used during general anesthesia in order to control @entity101 and @entity591 . It is well known that both @entity460 entry blockers (CEBs) and inhalation anesthetics have depressant effects on @entity713 . Therefore, this study was designed to evaluate combined effects of either @entity1508 , @entity4488 , @entity5161 , or @entity2614 and CEBs ( @entity1855 , @entity3988 , or @entity594 ) on AV conduction. The following 3 sets of experiments were performed using 90 mongrel @entity235 anesthetized with @entity3652 100-150 mg im, thiamylal 25 mg/kg iv and @entity3810 with 50% @entity26 . Experiment 1: to evaluate the effects of @entity3652 and thiamylal on AV conduction. Experiment 2: to evaluate drug interactions of @entity1508 with CEBs. Experiment 3: to evaluate the combined effects of four different inhalation anesthetics at equipotent concentrations (0.8% @entity1508 , 1.6% @entity4488 , 1.2% @entity5161 , and 1.7% @entity2614 ) and @entity1855 . The following variables were measured utilizing His bundle electrocardiogram: Sinus cycle length (SCL), AV conduction time (AH interval), His Purkinje conduction time (HV interval), effective and functional refractory period of AV node (ERP and FRP). It was confirmed that @entity3652 im and thiamylal iv used for induction of anesthesia did not change AV conduction time from experiment 1. The combined effects of either @entity1855 (0.1 mg/kg) or @entity3988 (0.15 mg/kg) and 0.8% @entity1508 were additive on AV conduction. Although @entity594 (0.01 mg/kg) did not affect AV conduction, there was the significant prolongation of SCL with @entity1508 compared to without @entity1508 . In experiment 3, 0.8% @entity1508 and 1.6% @entity4488 were stronger than 1.2% @entity5161 and 1.7% @entity2614 concerning inhibitory effects on AV conduction. @entity1855 had some deleterious effects in 1.6% @entity1508 or 3.2% @entity4488 anesthesia because of extreme inhibitory effects on AV conduction and sinus automaticity. In conclusion, caution must be exercised in usage of CEBs if inhalation anesthetics are used in higher concentrations.
