Signal decay mapping of XXXX using dual-contrast fast spin-echo MRI.

@entity1 @entity296 @entity4 @entity583 @entity2287
PURPOSE: To introduce a dual-contrast fast spin-echo (dcFSE) sequence for signal decay mapping of @entity296 . MATERIALS AND METHODS: After consultation with the Institutional Review Board, 22 acute @entity583 ( @entity583 ) @entity1 were examined with magnetic resonance imaging (MRI) at 1.5T 2 days after revascularization. @entity4 was evaluated in 16 @entity296 with an exponential fit for signal decay time (SDT) in dcFSE mapping and T2 signal intensity ratio for single-contrast FSE. Myocardial viability was evaluated in late @entity2287 enhancement (LGE). A control group of 10 volunteers was examined for @entity4 imaging. SDT was compared in segment groups: 1) with LGE in @entity583 , 2) penumbra, 3) remote from LGE, 4) controls. Groups 1/3 and 3/4 were tested on difference. Three phantoms providing similar T2 but different T1 relaxation times (low, intermediate, high) were examined with dcFSE and multicontrast spin echo sequence as a reference. RESULTS: The SDT/T2 ratio for segment groups was 1) 82msec/1.7 in segments with LGE; 2) 65msec/1.6 for penumbra, 3) 62msec/1.7 for remote segments, and 4) 50msec/1.6 in controls. In dcFSE group 1/3 (P < 0.0001) and in group 3/4 (P   =   0.0002) SDT was significantly different. In single-contrast FSE the T2 ratio was not significantly different for both tests: 1/3 P   =   0.1889; 3/4 P   =   0.8879. T2 -overestimation of dcFSE was 23% in low, 29% in intermediate, and 35% in highly T1 contaminated phantoms. CONCLUSION: dcFSE signal decay @entity4 mapping is feasible in volunteers and @entity1 . DcFSE SDT is superior to T2 ratio for detection of high-grade and diffuse @entity296 . J. Magn. Reson. Imaging 2015.
