@entity1904 and @entity1851 levels at admission as predictors of duration of acute @entity75 in XXXX @entity1 .

@entity1 @entity32 @entity295 @entity75 @entity1904 @entity3124 @entity772 @entity51 @entity933 @entity6948 @entity2934 @entity1851
INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity933 , though these relationships have not been studied in @entity3124 @entity1 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity1904 and @entity1851 ( @entity1851 ), and duration of acute @entity75 in ventilated @entity1 . METHODS: @entity1 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity51 (MENDS) trial were assessed daily for @entity933 using the Confusion Assessment Method-ICU. Plasma levels of @entity1904 and @entity1851 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity1904 and @entity1851 separately with @entity933 / @entity772 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity6948 vs. @entity2934 ), and @entity295 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity1 were included in this analysis. The median age of the @entity1 was 60 years with APACHE II scores of 28; 68% had @entity295 within 48 hours of admission. Higher levels of @entity1904 were associated with fewer @entity933 / @entity772 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity1851 levels showed trends towards fewer @entity933 / @entity772 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity295 . No associations were found between @entity1904 or @entity1851 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity75 , implicating @entity32 as an important mechanism in the pathophysiology of @entity933 and @entity772 during @entity3124 , irrespective of whether @entity1 had @entity295 or not.
