Sympathetic activity in @entity1000 . Influence of XXXX and @entity2514 .

@entity1 @entity2514 @entity3371 @entity1000 @entity2922 @entity916 @entity67 @entity1063
To study the interrelationship between myocardial @entity1063 content, left ventricular (LV) and right ventricular (RV) function, morphological changes, and plasma @entity2922 concentrations, 20 @entity1 with @entity1000 underwent endomyocardial biopsy and ventricular angiography. The strongest correlation was found between LV ejection fraction (EF) and myocardial @entity1063 content (r = 0.87; p less than 0.001). Myocardial @entity1063 content was much weaker correlated to RV EF (r = .55; p less than 0.005), and no correlation was found to morphological changes or plasma @entity1063 concentration. The hemodynamic and neurohumoral effects of @entity2514 versus @entity3371 after the first dose were compared in a crossover trial including 15 @entity1 with @entity1000 . @entity2514 induced increases in heart rate and cardiac index (p less than 0.01) and decreases in mean arterial pressure and pulmonary wedge pressure (p less than 0.01 and p less than 0.005, respectively). These hemodynamic effects were associated with increased plasma @entity1063 concentrations during upright exercise (p less than 0.05) and increased plasma @entity916 activity (p less than 0.01). After @entity3371 , @entity1063 plasma concentrations showed a tendency to lower levels during upright exercise, although mean arterial pressure decreased significantly (p less than 0.01). These data suggest that, in @entity1 with @entity1000 , myocardial @entity1063 depletion strongly reflects left @entity67 . The different patterns of neurohumoral response to @entity2514 versus @entity3371 may be important for their long-term effect and for the prognosis of @entity1 with @entity1000 . It remains to be established whether the myocardial @entity2922 content is differently influenced by either drug, and whether this effect is related to the drug response after long-term treatment.
