Strain differences in the development of acute tolerance to XXXX .

@entity19 @entity2340 @entity750 @entity10594 @entity1068 @entity2332
C57B1/6 @entity19 brain @entity750 levels were depleted by feeding animals a diet containing no @entity2340 . When such @entity19 were injected with @entity1068 , they were found to lose their righting reflex for significantly longer periods and to have a lower body temperature than control animals. Animals consuming the diet containing no @entity2340 metabolized @entity1068 more slowly than controls. Although daily injections of @entity10594 reinstated @entity1068 metabolism to normal, the duration of loss of righting reflex and the @entity2332 induced by @entity1068 were unaffected by @entity10594 pretreatment. @entity2340 (75 mg/kg) administered six hours prior to @entity1068 injection returned brain @entity750 levels to normal in @entity2340 -deprived @entity19 . @entity19 injected with @entity2340 were found to respond to @entity1068 as did the control animals. When brain @entity1068 levels were determined at the time the animals lost their righting reflex and when animals regained their righting reflex, @entity2340 -deprived @entity19 were found to regain the righting reflex at the same brain @entity1068 levels as those at which such animals lost their righting reflex. @entity2340 administration to @entity2340 -deprived @entity19 resulted in their regaining the righting reflex at higher @entity1068 levels than those at which they lost the reflex. Similar experiments were carried out on C3H/HeJ and DBA/J2 @entity19 . The results indicate that C3H @entity19 developed some acute tolerance while DBA @entity19 failed to develop any acute tolerance. The possibility exists that the strain difference in the degree of sensitivity to @entity1068 observed in these @entity19 may be due to differing abilities to develop acute tolerance.
