Baseline pathological and radiological assessment of @entity5 angiogenesis predicts survival in XXXX with @entity3271 .

@entity1 @entity410 @entity7499 @entity39 @entity5 @entity1373 @entity4498 @entity302 @entity1349 @entity3271
UNASSIGNED: 1545 Background. @entity5 ( @entity3271 ) is associated with @entity7499 ( @entity1373 , vascular proliferation of leaking vessels and @entity5 @entity39 ). Our aim was to evaluate the prognostic value of @entity5 angiogenesis assessed by pathological and radiological examinations on progression-free (PFS) and @entity1349 ( @entity1349 ) in @entity1 (pts) with @entity3271 . METHODS: All pts with @entity3271 consecutively treated in our Institution from 1994-2000. Pathological sections were re-evaluated to confirm the diagnosis of ODs and to assess the degree of nuclear atypia, @entity4498 , @entity1373 , and @entity39 . CT-scan and/or MRI images were re-analyzed to assess contrast enhancement and @entity39 . A multivariate analysis was performed including baseline demographic data, histological and radiological factors associated with @entity5 angiogenesis and treatment. RESULTS: 134 pts with histologically confirmed low grade (WHO grade II, n=49) and anaplastic @entity3271 (WHO grade III, n=85) were analyzed. Univariate analysis showed that prognostic factors associated with better PFS and @entity1349 were age <55 (p<0.0001), @entity3271 revealed by @entity410 (p<0.0001), lack of @entity1373 (p<0.001), lack of contrast enhancement (p=0.02), and lack of histological/radiological evidence of @entity5 @entity39 (p<0.0001). Multivariate analysis identified @entity39 , @entity1373 and/or contrast enhancement, age, and @entity410 as independent bad-prognostic factors for @entity1349 . This enabled us to defined three pts groups (low, intermediate, and high risk @entity3271 ) according to NEVA score using the more robust parameters ( @entity39 , @entity302 , vessel and age). CONCLUSION: Endothelial hyperplasia, contrast enhancement, and @entity39 that reflect a mutli-step development of @entity5 angiogenesis are independent factors of bad prognosis in pts with @entity3271 . No significant financial relationships to disclose.
