Speckle tracking echocardiography assessment of global and regional contraction dysfunction in the XXXX model of pressure overload.

@entity712 @entity1184 @entity1283 @entity19 @entity6475 @entity299 @entity2333
Speckle tracking echocardiography (STE) has been applied to the evaluation of @entity299 . However, there were few studies on alteration of global and regional STE parameters in the process of @entity1283 and @entity712 . In this study, STE was applied to evaluate the global and regional cardiac function under @entity712 and @entity1184 in the @entity19 model of pressure overload. Adult @entity19 were subjected to mild or severe aortic banding with a 25 Gauge (G) or 27 G needle. After surgery, STE and conventional echocardiography were used in the sham group (n=10), mild @entity2333 ( @entity2333 ) group (n=14) and severe @entity2333 group (n=10) for 8 weeks. The results showed that the @entity19 subjected to severe @entity2333 showed a significant change in fractional shortening (FS), left ventricular (LV) mass, and left ventricular end diastolic diameter (LVEDD) (P<0.05 for each). Meanwhile, there were no significant differences in FS and LVEDD between the sham group and mild @entity2333 group during the experimental procedures (P>0.05 for both). STE analysis revealed that @entity6475 ( @entity6475 ) was significantly decreased in the severe @entity2333 group as compared with the sham and mild @entity2333 groups (P<0.05 for both) from the postoperative week 1. @entity6475 in the mild @entity2333 group was reduced as compared to the sham group (P<0.05). @entity6475 ( @entity6475 ) and circumferential strain (CS) were significantly decreased in the severe @entity2333 group as compared to the sham group and the mild @entity2333 group (P<0.05 for both) from the postoperative week 1 (P<0.05 for both). Compared to the sham group, CS in the mild @entity2333 group maintained unchanged during the test period, and @entity6475 was reduced only on the postoperative week 6 (P<0.05). Finally, regional contraction dysfunction was analyzed in both @entity1184 in longitudinal and radial directions. It was found that @entity6475 was largest in the apex region and @entity6475 was smallest in the apex region in the healthy and @entity1184 . It was also found that compared to the sham group, only base @entity6475 in the mild @entity2333 group was decreased. Each of regional strain in the severe @entity2333 group was uniformly depressed in radial and longitudinal directions. It is concluded that STE has provided a non-invasive and highly feasible way to explore the global and regional contraction dysfunction in @entity1184 and @entity712 myocardium in the @entity19 model of pressure overload.
