A common variant near @entity2252 is associated with dietary XXXX intake in adolescents.

@entity71825 @entity18957 @entity18956 @entity20903 @entity28 @entity21944 @entity1628 @entity1735 @entity23158 @entity2252 @entity460 @entity23157 @entity11620 @entity71826 @entity24854 @entity23156
UNASSIGNED: Specific targets for most @entity28 candidate genes discovered by genomewide association studies remain unknown. Such genes are often highly expressed in the hypothalamus, indicating their role in energy homeostasis. We aimed to evaluate the associations of selected gene variants with adiposity and dietary traits. Anthropometric parameters, fat mass, dietary intake (total energy, fat, protein, @entity1735 , fiber, and @entity460 ) and 10 gene variants (in/near @entity20903 , @entity21944 , @entity23157 , @entity11620 , @entity2252 , @entity23156 , @entity1628 and @entity18957 ) were analyzed in 1953 Czech individuals aged 10.0 to 18.0 years (1035 nonoverweight and 918 overweight: body mass index [BMI] >= 90th percentile). Obesity risk alleles of @entity20903 @entity71825 , @entity23156 @entity71826 , and @entity18957 @entity18956 were related to increased body weight and BMI (P < .005). The @entity18957 variant also showed a significant positive association with waist circumference and fat mass (P < .001). Overweight adolescents had a lower total energy intake (P < .001) but a higher percentage of fat (P = .009) and protein intake (P < .001) than the nonoverweight subjects. There was also a lower @entity460 intake in the overweight group (P < .001). An association with at least one component of dietary intake was found in 3 of 10 studied gene variants. The @entity1628 @entity24854 was associated negatively with protein (P = .012) and positively associated with fiber (P = .032) intakes. The @entity28 risk alleles of @entity2252 @entity23158 and @entity18957 @entity18956 were related to a lower @entity460 intake (P = .001 and .037). The effects of @entity18957 and @entity1628 variants, however, disappeared after corrections for multiple testing. Our results suggest that the common @entity2252 variant may influence dietary @entity460 intake independent of BMI.
