Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized XXXX for @entity378 .

@entity1 @entity2167 @entity1906 @entity5052 @entity378 @entity1907
OBJECTIVE: Side effects of the most commonly used primary antituberculosis (anti- @entity1906 ) drugs may be mild as well as fatal. The aim of this study was to evaluate the side effects of and the risk factors for developing side effects against anti- @entity1906 drugs. @entity1 AND METHODS: Records of 1149 @entity1 with established @entity378 who initially received anti- @entity1906 therapy were evaluated retrospectively. The major side effects, which resulted in a definitive termination from 1 or more drugs related to anti- @entity1906 therapy, and the risk factors associated with these side effects, were analyzed. RESULTS: Ninety-five @entity1 (8.3%), constituting 104 cases in total, experienced side effects. Although the frequency of drug reactions were increased from 0.6% at ages <20 to 5.2% at ages 20-40, no gender or age differences were observed between @entity1 who did and did not have side effects. While asymptomatic liver function disturbance was established in 56 of the @entity1 (4.9%) with initiation of anti- @entity1906 therapy, the rate of hepatotoxicity was found to be 2.4% in this present study. No age or gender differences were observed among those who had hepatotoxicity and who had not. The major side effects were @entity2167 (1.7%), hepatotoxicity (0.8%), neuropsychiatric manifestations (0.7%), and @entity5052 (0.6%). CONCLUSIONS: It must be remembered that severe side effects associated with anti- @entity1906 drugs were encountered with different frequencies especially among @entity1 hospitalized for @entity1907 , and these @entity1 should be followed up by closer monitoring for side effects related to anti- @entity1906 drugs.
