Detection of surface antigen 17-1A in breast and XXXX .

@entity5960 @entity0 @entity5 @entity406 @entity982 @entity14
Substantial progress has been made in detecting cell surface or intracytoplasmatic antigens to identify @entity5 cells with monoclonal antibodies (MAbs). The 17-1A antigen is already used as a target for specific immunotherapy in @entity14 . The purpose of this study was to compare the expression of 17-1A antigen in @entity0 . MAb against the @entity5960 and a routine staining technique were used to detect the 17-1A antigen in 100 cases of colorectal and 111 cases of @entity0 . The antigen expression of each @entity5 entity was examined by light microscopy on paraffin sections. Thirty six of the @entity406 -fixed paraffin sections of @entity0 were compared with their corresponding frozen sections. Evaluation was realized by a histological score (grade 0-9) considering the distribution and the staining intensity. We found an antigen expression of 17-1A in @entity14 quantified at 7.1+/-1.8 and at 4.5+/-2.5 for @entity0 in our score. Comparing paraffin sections and frozen sections in the 36 cases of @entity0 , the score was 5.5+/-2.3 in the paraffin and 8.1+/-1.9 in the frozen section group. Our results confirmed the high expression of 17-1A cases of in @entity14 . Furthermore, 17-1A is expressed in the majority of @entity0 , revealing a high difference between @entity982 and frozen sections. As a result, a specific immunotherapy with MAbs against 17-1A antigen in minimal residual stages of @entity0 might be considered.
