XXXX exposure alters neonatal development.

@entity19 @entity7459 @entity6836
@entity7459 ( @entity6836 ) is one of the commonly encountered environmental contaminants. Experiments were carried out to test for neonatal behavioral alterations associated with prenatal @entity6836 exposure. Pregnant CD-1 @entity19 were exposed in environmental chambers to 0, 22, or 45 ppm of @entity6836 in air from gestation day 7 to 18. The gas-air flow was set at 450 ml/min. Food and water were available at all times. The dams were allowed to deliver and neonatal behavioral development of the pups was studied. @entity7459 exposure did not affect the number of live pups born/litter; however, it significantly decreased their birth weight. Prenatal @entity6836 exposure at both levels significantly altered the righting reflex and aerial righting score of the pups on postnatal days 1 and 12, respectively. Prenatal @entity6836 exposure did not affect negative geotaxis and activity scores of pups on postnatal day 10 and 28, respectively. The data suggest that maternal @entity6836 exposure at low levels can affect neuromuscular coordination and thus produce deficits in the functional capability of the offspring.
