Anorectal contractility under basal conditions and during rectal infusion of saline in XXXX .

@entity1 @entity1960 @entity31 @entity322
Pressure activity in the rectum and anal canal was measured with a multilumen probe in 29 @entity1 with @entity31 (12 active, 11 quiescent, six studied during both phases) and 18 normal controls under resting conditions and during rectal infusion of saline. Resting motor activity was significantly decreased in @entity1 with @entity1960 compared with quiescent @entity1960 (p less than 0.005) and normal controls (p less than 0.001). Forty per cent of active colitics showed a featureless record compared with only one @entity1 with quiescent @entity1960 and one normal subject. The volume of saline infused before leakage occurred, and the total volume retained were significantly lower (p less than 0.001) in @entity1 with active and quiescent @entity1960 compared with normal controls. Rectal infusion of saline provoked regular rectal contractions, of significantly higher (p less than 0.05) amplitude in @entity1 with @entity1960 , than in quiescent @entity1960 or controls. These rectal contractions were associated with simultaneous anal relaxations. During saline infusion, peak and pressures were lower in @entity1 with @entity31 than in normal subjects, but there were no significant differences in relaxation pressures. In normal subjects, the rectal pressures remained below the anal pressures throughout the saline infusion. Peak rectal pressures exceeded the anal relaxation pressures during the last five minutes of saline infusion in @entity1 with @entity31 and throughout the infusion in those @entity1 who complained of @entity322 . Results suggest that although the resting rectal motor activity is diminished in @entity1 with @entity31 , luminal distension causes the inflamed rectum to generate abnormally strong contractions that may threaten continence.
