Past and present strategies of research on the XXXX in psychiatry.

@entity1 @entity308 @entity353 @entity146 @entity167 @entity699 @entity619 @entity701 @entity2270
@entity699 in @entity308 has been extensively studied during the last three decades. The main hypothesis regarding origin and clinical relevance of this phenomenon, however, has changed significantly. Up to the mid-seventies @entity699 was conceived as consequence of stress modified by the degree of unconscious defense mechanisms in different forms of @entity308 or non- @entity308 @entity146 . At the end of the seventies this point of view changed considerably. @entity699 was regarded as a biological statemarker of the endogenous subtype of @entity308 with clinical differential-diagnostic relevance. An abnormal @entity619 suppression test (DST) was assumed to be the best indication of increased activation of the @entity701 system. These conclusions turned out to be wrong. DST results are not specific for @entity308 and the test seems to be of limited value for measuring the function of the @entity2270 . Intervening variables, such as @entity353 , drug and @entity167 withdrawal or situational stress, influence the test results significantly, independent of the nosological classification. Additionally, interindividual differences in the susceptibility of the @entity2270 may decisively influence the the activation of the @entity2270 as well in healthy subjects under stress as in @entity146 @entity1 .
