Pharmacokinetic studies on XXXX with special reference to age.

@entity1 @entity2841 @entity3897
Pharmacokinetic studies on @entity3897 were performed in 52 @entity1 under general or spinal anaesthesia. Age had a clinically significant effect on the kinetics of this alkaloid: in @entity1 under 2 years of age and in the elderly a prolonged elimination was found. This might explain, partly at least, the higher sensitivity of these age groups to the effects of @entity3897 . Age had no effect on the serum protein binding of this alkaloid. @entity3897 was found in @entity1 @entity2841 after a single i.m. administration, but not after a single i.v. administration. During anaesthesia after i.v. @entity3897 administration, a diminished cardiovascular response was found in the elderly in comparison with healthy adult @entity1 . This indicates changes also at the cholinergic receptor sites in the elderly.
