Prolonged latency of preterm premature @entity397 and risk of XXXX .

@entity1 @entity32 @entity295 @entity2399 @entity397 @entity13493 @entity306
BACKGROUND: @entity13493 ( @entity13493 ) is associated with @entity32 and infection, and it may involve the loss of a barrier to ascending infection from the vagina, and it is possible that prolonged @entity13493 could be an independent risk factor for @entity295 . OBJECTIVE: The objective of the study was to determine whether prolonged latency after @entity13493 is associated with an increased risk of @entity295 . STUDY DESIGN: This secondary analysis of the randomized controlled trial of @entity2399 for the prevention of @entity306 evaluated whether the time interval between diagnosis of @entity13493 and delivery was associated with an increased risk of @entity295 . Latency time was categorized by weeks of latency (0 weeks to >=  4 weeks). The primary outcome was confirmed @entity295 . Logistic regression was used to control for confounders. RESULTS: A total of 1596 @entity1 with @entity13493 were analyzed, of whom 1390 had a < 4-week interval and 206 had an interval of >=  4 weeks. @entity295 occurred in 15.5% of @entity1 in the cohort. In the univariate analysis, @entity1 in the prolonged @entity13493 group were less likely to have @entity295 (6.8% vs 17.2%, relative risk, 0.40 95% confidence interval, 0.24-0.66). This relationship was retained in the multivariable model; @entity1 with prolonged @entity13493 >=  4 weeks had an adjusted odds ratio of 0.21 (95% confidence interval, 0.10-0.41) for @entity295 . @entity295 was also significantly associated with earlier gestational age at @entity397 . CONCLUSION: Prolonged exposure to an intrauterine environment of @entity13493 does not increase the risk of @entity295 ; prolonged @entity13493 >=  4 weeks was associated with decreased risk of @entity295 .
