[Treatment of thoracolumbar XXXX with single posterior debridement, bone grafting, internal fixation and local chemotherapy].

@entity1 @entity3083 @entity1906 @entity1566 @entity717 @entity85 @entity130
OBJECTIVE: To evaluate the clinical effects of single posterior debridement, bone grafting, internal fixation and local chemotherapy in treating thoracolumbar @entity3083 . METHODS: From February 2009 to September 2012,11 @entity1 with thoracolumbar @entity3083 were treated by single posterior debridement, bone grafting, internal fixation and local chemotherapy. There were 7 males and 4 females, aged from 27 to 65 years old with an average of 53.7 years. The courses of disease was from 3 months to 2 years with the mean of 9 months. According to ASIA standard of @entity1566 , 3 cases were grade C and 8 cases D. After treatment, clinical effects were evaluated by ASIA grade, visual analogue score (VAS) and @entity717 Index (ODI); kyphosis Cobb angle change was observed by X-rays. RESULTS: Eleven @entity1 were followed up from 12 to 29 months with an average of 18 months. ASIA grade of @entity1566 , 3 @entity1 with grade C improved to grade D in 2 cases and grade E in 1 case 8 @entity1 with grade D improved to grade E in 7 cases and unchanged in 1 case. VAS decreased from preoperative 6.10    1.30 to 1.70    0.80 at 3 d after operation (P < 0.05). ODI improved from preoperative (68.36    10.41)% to (14.55    8.99)% (P < 0.05) at 3 d after operation. Kyphotic Cobb angle was corrected from preoperative (22.64    4.84)   to (4.27    1.49)   (P < 0.05) on the 3rd day after operation, and angle loss was mild at final follow-up, there was no significant difference between postoperative at 3 d and final follow-up. CONCLUSION: Single posterior debridement, bone grafting, internal fixation and local chemotherapy for the treatment of thoracolumbar @entity3083 can effectively remove the lesion, improve nerve function and @entity85 , has advantage of single incision, @entity130 , and low recurrence rate. But it still need long-term and systemic treatment with anti- @entity1906 drugs.
