Evaluation of a XXXX removal filter on irradiated red cells stored in SAGM.

@entity1 @entity3529 @entity4024 @entity1358 @entity972 @entity4144
BACKGROUND AND OBJECTIVES: Irradiation of red cell concentrates RCCs) can lead to well-documented elevated extracellular @entity972 concentrations. Transfusion of these products has the potential, if given as a massive/rapid transfusion, to lead to transient @entity4144 . A @entity972 absorption filter (PAF) has recently been developed and has been proven to effectively remove excess @entity3529 . However, data are lacking on the red cell quality parameters over storage after irradiation. METHODS: Thirty RCCs were pooled and split into 3 groups of 10. All RCCs were irradiated on day 14 and filtered on day 28 (group 1 control), day 15 (group 2) or day 17 (group 3). Pre-irradiation, pre- and post-filtration and day 28 samples were taken for each study. Standard red cell quality parameters were measured over storage at the above time points. RESULTS: Losses for haemoglobin, haematocrit and volume were minimal after filtration with all units containing >40   g Hgb   unit(-1) . Statistically, significant differences were observed for @entity3529 and @entity4024 levels in groups filtered at either 24 or 72   h post-irradiation, and this was observed directly after filtration and remained by day 28. Filtration had no significant impact on any other parameters measured. CONCLUSIONS: PAF effectively removed supernatant @entity972 (93%) from all @entity1358 units. Early removal of @entity3529 at either day 15 or 17 on RCCs subsequently stored to day 28 had no measurable effect on red cell quality, suggesting this may be a useful device to ensure further safety for at-risk immunocompromised @entity1 groups requiring irradiated RCCs.
