XXXX With Gestational Diabetes Randomized to a Higher-Complex @entity1735 /Low-Fat Diet Manifest Lower Adipose Tissue @entity2690 Resistance, Inflammation, @entity413 , and Free Fatty Acids: A Pilot Study.

@entity1 @entity6 @entity28 @entity2690 @entity1735 @entity413 @entity3691 @entity1386
OBJECTIVE: Diet therapy in @entity6 ( @entity6 ) has focused on @entity1735 restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low- @entity1735 /higher-fat (LC/CONV) diet, hypothesizing that a higher-complex @entity1735 /lower-fat (CHOICE) diet would improve maternal @entity2690 resistance (IR), @entity1386 ( @entity1386 ) lipolysis, and @entity1 @entity1386 . RESEARCH DESIGN AND METHODS: At 31 weeks, 12 diet-controlled overweight/ @entity28 @entity1 with @entity6 were randomized to an isocaloric LC/CONV (40% @entity1735 /45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. @entity1386 was biopsied at 37 weeks. RESULTS: After    7 weeks, fasting @entity413 (P = 0.03) and @entity3691 (P = 0.06) decreased on CHOICE, whereas fasting @entity413 increased on LC/CONV (P = 0.03). @entity2690 suppression of @entity1386 lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. @entity1386 expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). @entity1 @entity1386 trended lower with CHOICE (10.1    1.4 vs. 12.6    2%, respectively). CONCLUSIONS: A CHOICE diet may improve maternal IR and @entity1 @entity1386 , challenging recommendations for a LC/CONV diet.
