Characteristics and Survival of @entity0 XXXX with Multiple Synchronous or Metachronous Primary Cancers.

@entity1 @entity0 @entity5 @entity1558 @entity259 @entity204
PURPOSE: Newly developed extra-mammary @entity5 ( @entity5 ) are an issue of concern when considering the management of @entity0 survivors. This study aimed to investigate the prevalence of @entity5 and to evaluate the implications of @entity5 on the survival of @entity0 @entity1 . MATERIALS AND METHODS: A total of 8204 @entity1 who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of  <=5 and >5 years were investigated using univariate and multivariate analyses. RESULTS: During a mean follow-up of 67.3 months, 962 @entity5 in 858 @entity1 (10.5%) were detected. Synchronous and metachronous @entity5 were identified in 23.8% and 79.0% of @entity1 , respectively. @entity259 was the most prevalent, and the second most common was @entity5 . At  <=5 years, @entity1 with @entity5 were older and demonstrated significantly worse survival despite a higher proportion of @entity1 with lower-stage @entity5 . Nevertheless, an increased risk of @entity204 in @entity1 with @entity5 did not reach statistical significance at >5 years. The causes of @entity204 in many of the @entity1 with @entity5 were not related to @entity0 . Stage-matched analysis revealed that the implications of @entity5 on survival were more evident in the early stages of @entity1558 . CONCLUSION: @entity0 @entity1 with @entity5 showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in @entity0 survivors and to establish guidelines for improving prognosis and quality of life.
