Programming of adult @entity65 following exposure to late-gestation XXXX .

@entity1 @entity2175 @entity6 @entity63 @entity1602 @entity413 @entity299 @entity35 @entity67 @entity4854 @entity65
BACKGROUND: In utero exposure to @entity4854 is becoming increasingly prevalent as the number of @entity1 entering pregnancy with @entity2175 , or developing gestational @entity6 , increases. Both animal studies and epidemiologic investigations have found @entity65 in adult offspring of @entity1602 mothers (OHM). OBJECTIVE: We hypothesized that adult OHM would have abnormal cardiac function in vivo and increased susceptibility to @entity63 . METHODS: Pregnant @entity35 were made @entity6 on day 12 of gestation. Serum @entity413 was monitored twice daily and insulin provided to maintain serum @entity413 at 200-400 mg/dl. Offspring were fostered to normal mothers after birth. Adult OHM were studied at 8-10 months of age with echocardiography to assess in vivo cardiac function and isolated hearts to determine the response to @entity63 . RESULTS: Echocardiography found significant @entity67 in male OHM compared to male controls. In isolated hearts, baseline cardiac function and left ventricular compliance was significantly diminished in male OHM compared to controls. @entity63 caused a significant decline in heart function in controls and female OHM, while function in male OHM remained unchanged. CONCLUSIONS: Adult male OHM demonstrate programmed @entity299 . Given the growing number of pregnancies complicated by @entity4854 , additional assessment of cardiac function of adults born to @entity6 mothers may be warranted.
