I.V. infusion of @entity2400 during spinal anaesthesia improves postoperative XXXX .

@entity1 @entity1337 @entity6058 @entity2400 @entity1209 @entity86 @entity1286 @entity282 @entity1760
BACKGROUND: In a randomized, double-blind, prospective study, we have evaluated the effect of i.v. infusion of @entity2400 during spinal anaesthesia on postoperative @entity1337 and postoperative analgesic requirements. METHODS: Forty @entity1 undergoing total hip replacement arthroplasty under spinal anaesthesia were included. After the induction of spinal anaesthesia, the @entity1760 group (Group M) received @entity2400 50 mg kg(-1) for 15 min and then 15 mg kg(-1) h(-1) by continuous i.v. infusion until the end of surgery. The saline group (Group S) received the same volume of isotonic saline over the same period. After surgery, a @entity1 -controlled @entity1337 (PCA) device containing @entity1286 and @entity6058 was provided for the @entity1 . @entity282 scores, PCA consumption, and the incidences of shivering, postoperative @entity1209 were evaluated immediately after surgery, and at 30 min, 4, 24, and 48 h after surgery. Serum @entity1760 concentrations were checked before the induction of anaesthesia, immediately after surgery, and at 1 and 24 h after surgery. RESULTS: @entity282 scores were significantly lower in Group M at 4, 24, and 48 h after surgery (P<0.05). Cumulative @entity86 were also significantly lower in Group M at 4, 24, and 48 h after surgery (P<0.05). Postoperative @entity1760 concentrations were higher in Group M (P<0.05 at 4, 24, and 48 h after surgery), but no side-effects associated with hypermagnesemia were observed. Haemodynamic variables and the incidences of shivering, @entity1209 were similar in the two groups. CONCLUSIONS: I.V. @entity2400 administration during spinal anaesthesia improves postoperative @entity1337 .
