XXXX inhibits the inflammatory process of the @entity1543 -induced @entity1960 in the @entity35 colonic mucosa.

@entity32 @entity39 @entity5 @entity16 @entity568 @entity3542 @entity6693 @entity29 @entity1507 @entity1960 @entity1234 @entity842 @entity3426 @entity35 @entity1589 @entity224 @entity1543
UNASSIGNED: @entity29 is a serious health problem. Although it has been widely investigated, treatment of @entity29 currently remains as a challenging clinical problem. Over production of @entity842 has been demonstrated to cause tissue damage and @entity32 . In this study, the effect of @entity6693 (MB), a well-known inhibitor of @entity842 synthesis, was investigated in @entity1543 (AA)-induced @entity1960 model in @entity35 . Eighty male @entity35 randomized into 4 groups (control, control MB, @entity1960 , @entity1960 + MB). AA was applied to groups 3 and 4. MB was added into group 2 and 4. Three days later, animals were sacrificed and 8 cm distal colonic segment resected and the specimens are examined using macroscopical, histological, and biochemical methods. The results of the macroscopic and microscopic examination showed that in group 4 the @entity16 and @entity32 score significantly lower than group 3. Increased intestinal permeability in @entity1543 -administered group was significantly reversed by MB application. @entity1589 activity and @entity1234 levels increased significantly, while @entity224 dismutase and catalase activities were suppressed after AA-administration. These biochemical parameters were reversed in MB-treated group. Administration of @entity1543 resulted in increased levels of @entity5 @entity39 factor-a, @entity3426 , @entity568 , total @entity3542 / @entity1507 levels and @entity842 synthase activity. These biochemical alterations were significantly reversed by MB application also. In conclusion, our results indicate that MB decreases the level of @entity842 and decreases @entity32 in @entity1543 -induced @entity1960 .
