Higher weight at birth is related to decreased maternal XXXX oxidation during pregnancy.

@entity1 @entity1522 @entity1568 @entity1133 @entity535 @entity65 @entity13140
BACKGROUND: Small size at birth is associated with @entity65 in adult life. Decreased fetal growth may result from a limitation in the nutrient supply to the fetus. Net tissue deposition in the mother and fetus increases the demand for @entity1568 , but because maternal consumption of protein does not increase, there must be a change in the partitioning of @entity1522 , away from oxidation and toward deposition. OBJECTIVE: Our objective was to characterize @entity535 oxidation in pregnancy and to investigate whether the relative partitioning of @entity1522 was related to fetal growth. DESIGN: We determined @entity535 oxidation as @entity1133 production in 25 @entity1 during mid (17-19 wk) and late (26-29 wk) gestation. @entity1133 production was measured from urinary [ @entity13140 -(15)N]urea excretion over 48 h after a single oral dose of [ @entity13140 -(15)N]urea. We measured the @entity1 's size at birth. RESULTS: For the group as a whole, @entity1133 excretion decreased and @entity535 oxidation remained similar between mid and late pregnancy, but there was wide variation between the @entity1 . Heavier @entity1 were born to the mothers in whom @entity535 oxidation decreased the most during pregnancy (slope of regression line: -80 g x g N(-1) x d(-1); 95% CI: -129, -31; P = 0.003). After adjustment for length of gestation and the @entity1 's sex, the change in maternal @entity535 oxidation explained 34% of the variation in birth weight. CONCLUSIONS: @entity535 oxidation varied widely between the @entity1 during pregnancy. Understanding the ability of a pregnant @entity1 to adapt metabolically may have implications for establishing dietary recommendations in pregnancy.
