Proliferation in African @entity0 : biology and prognostication in nigerian XXXX material.

@entity5 @entity1 @entity2194 @entity0
Three hundred cases of invasive @entity0 from the University of Calabar Teaching Hospital, Nigeria were subjected to evaluation of proliferative activity by mitotic counts. The prognostic significance and association with other prognostic factors were evaluated. The mitotic activity was expressed as mitotic activity index (MAI), and standardized mitotic index (SMI). Pearson's correlation and univariate and multivariate Cox's regression were used. The mean follow-up time was 25.9 months. The mean values of SMI and MAI were 42.6 mitotic figures per square millimeter and 30.5 mitotic figures per 10 high-power fields, respectively, and these were much higher than values reported for Europe or other Western countries. The SMI had a positive correlation with @entity5 size (r = 0.31, P <.0001), histologic grade (r = 0.68, P <.0001), nuclear area (r = 0.45, P <.0001), and negative correlation with fraction of @entity2194 ( @entity2194 ; r = -0.56, P = <0.0001). There was no statistically significant difference in the mitotic activity between the postmenopausal and the premenopausal @entity1 . Also, lymph node-positive @entity1 had higher counts than did lymph node-negative @entity1 . Earlier determined grading associated decision thresholds divided the @entity1 into groups of favorable and unfavorable prognosis. However, the statistically optimal thresholds for Nigerian material were different (32 and 92 mitotic figures per square millimeter for SMI). @entity5 size of 5 cm, SMI, and MAI were independent prognostic factors. Nigerian @entity0 are high-grade, high-stage, and high-proliferating @entity5 occurring in a younger population than those of the Western countries. Proliferation is also more active. Evaluation of SMI or MAI can improve the distinction between aggressive and @entity0 .
