Biochemical rationale and myocardial tissue data on the effective therapy of XXXX with coenzyme Q10.

@entity1 @entity296 @entity1503 @entity7447
The tissue levels of @entity7447 ( @entity7447 ) in endomyocardial biopsy samples and blood from 43 @entity1 with @entity296 were determined by steps of extraction, purification, and HPLC. The biopsy samples were obtained from the @entity1 after a routine heart catheterization. Six @entity1 were of class I, 18 of class II, 11 of class III, and 8 of class IV (classified according to guidelines of the New York Heart Association). True control biopsies of healthy hearts are not available for ethical reasons, but the data of the four classes by severity of disease may be justifiably compared. @entity1 of class IV had lower (P less than 0.01) levels of @entity7447 than those of class I. @entity1 of classes III and IV had a lower (P less than 0.0001) level than those of classes I and II. Biopsy samples were obtained from five @entity1 after treatment with @entity7447 for 2-8 months. The increases of @entity7447 levels ranged from 20% to 85%; the mean value was higher (P less than 0.02) than before treatment. @entity1503 also increase with severity of disease, but not as markedly as for the biopsies. These data reveal a @entity296 of @entity7447 , which is higher with increasing severity of disease and is reduced by therapy. This biochemistry correlates with the effective treatment of @entity296 with @entity7447 .
