Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After XXXX Administration.

@entity1 @entity10789 @entity23432 @entity7241 @entity1559 @entity2287
OBJECTIVES: The aim of this study was to compare changes in signal intensity (SI) ratios of the @entity10789 ( @entity10789 ) to pons and cerebrospinal fluid (CSF) on unenhanced T1-weighted magnetic resonance imaging (MRI) scans between the first and last MRI using the linear @entity2287 -based contrast agent @entity23432 . MATERIALS AND METHODS: The study was approved by the ethical committee of the University of Heidelberg (S-324/2014), and written informed consent was waived due to the retrospective character of the study. Fifty @entity1 who underwent at least 5 consecutive MRI examinations (plus an additional last MRI for reference) with the exclusive use of @entity23432 were analyzed retrospectively. The difference of @entity10789 -to-pons and @entity10789 -to-CSF mean SI ratios was calculated on unenhanced T1-weighted images between the first and last examination. Results were compared with previously published data on @entity7241 and gadoterate @entity1559 . RESULTS: Signal intensity ratio differences for @entity10789 -to-pons and @entity10789 -to-CSF were significantly greater than 0 (pons: 0.0399    0.0307, P < 0.001; CSF: 0.1439    0.1524, P < 0.001). No control variable consistently predicted the SI ratio difference for the @entity10789 -to-pons and the @entity10789 -to-CSF ratio. Compared with previously published data, the difference in SI increase between @entity7241 and @entity23432 was not significant for the @entity10789 -to-pons ratio (P = 0.906). In contrast, the @entity10789 -to-CSF ratio difference was significantly lower (P < 0.001) for @entity23432 . Dentate nucleus-to-pons (P < 0.001) and @entity10789 -to-CSF (P = 0.017) ratio differences were both significantly higher for @entity23432 than for gadoterate @entity1559 . CONCLUSIONS: The present study found an increase in SI in the @entity10789 after serial injections of @entity23432 . Further studies are needed to clarify the potential of different linear @entity2287 -based contrast agents to cause SI increase in the @entity10789 .
