XXXX in childhood: long-term results of treatment.

@entity1 @entity1032 @entity1376 @entity2124 @entity717 @entity2946
Thirty-one @entity1 under the age of 15 years with verified @entity2946 were treated at Addenbrookes Hospital from 1940 to 1976. In addition to surgical treatment, all received high dose irradiation to the whole neuraxis. Nine were still alive in 1979, of whom eight were examined. All these @entity1 showed some residual problems, but five were leading active lives and had only minor @entity717 . There was evidence of disturbance in growth, with shortening of the spine in relation to the limbs, in all the @entity1 . The height centile was lower than expected from parental height in four and one was severely dwarfed. @entity2124 secretion in response to exercise was, however, normal in five of six @entity1 tested. Three @entity1 also showed failure of growth of the jaw sufficiently severe to be a cosmetic problem. @entity1032 was present in three @entity1 . A raised resting TSH level was found in two @entity1 , one of whom had a @entity1376 . Of the three @entity1 with severe problems, two had been treated when under two years of age. Long-term follow-up of @entity1 who survive @entity2946 is clearly necessary and consideration should perhaps be given to revision of current treatment regimes in very young @entity1 .
