Severity of acid @entity354 assessed by pH metry: is it associated with XXXX ?

@entity1 @entity66 @entity391 @entity344 @entity177 @entity1576 @entity354
About 50% of @entity1 with chronic @entity1576 ( @entity1576 ) have "silent" @entity354 ( @entity354 ). Our purpose was to evaluate the possibility that @entity1576 in @entity1 with @entity354 reflects the presence of more severe acid reflux. We compared the severity of parameters from pH studies in @entity1 with chronic @entity1576 and "silent" @entity354 , to @entity1 with signs of symptomatic @entity344 with and without @entity1576 . This study included 236 @entity1 (aged 1 month to 15 years) with abnormal 24-hr pH monitoring among 718 @entity1 studied for suspected diagnosis of @entity354 . @entity1 were divided into three groups. Group 1 consisted of @entity1 with chronic @entity1576 but without any @entity344 of @entity354 . Group 2 was comprised of @entity1 with symptomatic GI presentation of @entity354 such as regurgitation, @entity391 , heartburn, and @entity177 to thrive, but without any signs or symptoms of @entity1576 . Group 3 included @entity1 with prevalent @entity1576 and concomitant signs of symptomatic @entity354 . @entity1 with predominant GI manifestations (group 2) had a significantly higher fraction of time with pH <4 (P < 0.01), total time value of pH <4 (P < 0.05), and longest episode with pH <4 (P < 0.05). Esophageal clearance was significantly longer in group 1 @entity1 than in the other two groups (P < 0.05). @entity1 with @entity66 (group 3) were similar to @entity1 in group 2. @entity1 with @entity344 had significantly worse scores for all parameters evaluated except esophageal clearance score, compared to @entity1 without @entity344 . Longer esophageal clearance was the only parameter associated with respiratory signs in @entity1 with @entity1576 compared to those without. In conclusion, the presence of @entity1576 in pediatric @entity1 with silent @entity354 is related to longer esophageal clearance, but is not related to severity of reflux.
