Immunohistochemistry in XXXX and @entity706 .

@entity706 @entity5734 @entity5824 @entity1195 @entity4910 @entity2282 @entity1778 @entity5823 @entity1892 @entity1583 @entity1073 @entity2935 @entity978 @entity10317
The characterization of the antigenic and immunologic properties of @entity1583 has dramatically increased our understanding of the biology of these diseases and at the same time greatly enhanced our diagnostic abilities. Immunophenotyping has helped delineate specific lineage aberrancies indicative of malignant transformation, such as monoclonality, in the form of light- and/or heavy-chain immunoglobulin restriction, or loss of pan-B or pan-T cell antigens, or aberrant crosslineage coexpression of antigens. Unique immunophenotypic profiles have now been described for most forms of @entity706 and @entity1778 . Classic @entity978 , for example, has the singular combination of @entity5824 and @entity5823 positivity, in the absence of @entity1195 (see Fig. 1 ). Additional examples are @entity1073 with its unique nuclear expression of @entity4910 , and @entity5734 , characterized by coexpression of @entity10317 and @entity2935 , a monocytoid marker. Beyond its diagnostic utility, immunohistochemistry (IHC) may have prognostic significance reflecting the biologic behavior of these diseases; a case in point is @entity2282 in large @entity1892 , whose absence conveys a worse prognosis. Fig. 1. Classic @entity978 phenotype. Reed-Sternberg cell (upper left) coexpressing @entity5824 (upper right) and @entity5823 (lower right), in the absence of @entity1195 (lower left).
