Blueberries improve endothelial function, but not blood pressure, in adults with XXXX : a randomized, double-blind, placebo-controlled clinical trial.

@entity1 @entity450 @entity209
Blueberry consumption has been shown to have various health benefits in @entity1 . However, little is known about the effect of blueberry consumption on blood pressure, endothelial function and insulin sensitivity in @entity1 . The present study investigated the role of blueberry consumption on modifying blood pressure in subjects with @entity209 . In addition, endothelial function and insulin sensitivity (secondary measurements) were also assessed. A double-blind and placebo-controlled study was conducted in 44 adults (blueberry, n = 23; and placebo, n = 21). They were randomized to receive a blueberry or placebo smoothie twice daily for six weeks. Twenty-four-hour ambulatory blood pressure, endothelial function and insulin sensitivity were assessed pre- and post-intervention. The blood pressure and insulin sensitivity did not differ between the blueberry and placebo groups. However, the mean change in resting endothelial function, expressed as reactive @entity450 index (RHI), was improved significantly more in the group consuming the blueberries versus the placebo group (p = 0.024). Even after adjusting for confounding factors, i.e., the percent body fat and gender, the blueberry group still had a greater improvement in endothelial function when compared to their counterpart (RHI; 0.32    0.13 versus -0.33    0.14; p = 0.0023). In conclusion, daily dietary consumption of blueberries did not improve blood pressure, but improved (i.e., increased) endothelial function over six weeks in subjects with @entity209 .
