Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of XXXX .

@entity1 @entity5 @entity2225 @entity3 @entity14 @entity99
BACKGROUND: Hepatic metastases from @entity14 frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from @entity14 and to determine their clinical significance. METHODS: Fifty-three @entity1 underwent curative hepatic resection for @entity14 metastases. Multiple tissue sections were cut from the advancing margin of the largest hepatic @entity3 in each @entity1 and were stained with an antibody against @entity2225 to detect hepatic micrometastases, which were defined as discrete microscopic @entity5 surrounding the dominant @entity3 . RESULTS: Normal hepatocytes and intrahepatic bile duct epithelia stained negative for @entity2225 in all @entity1 , whereas the largest @entity99 stained positive in 46 @entity1 (86.8%). Among the 46 @entity1 with @entity99 that were positive for @entity2225 , hepatic micrometastases were found immunohistochemically in 32 @entity1 (69.6%). The presence of hepatic micrometastases was associated with a larger number of macroscopic hepatic metastases (P = 0.047) and @entity1 with hepatic micrometastases were found to demonstrate a higher probability of intrahepatic recurrence (P = 0.003) compared with those @entity1 without hepatic micrometastases. In addition, @entity1 with hepatic micrometastases demonstrated a worse survival (10-year survival rate of 21.9%) compared with those @entity1 without hepatic micrometastases (10-year survival rate of 64.3%) (P = 0.017). CONCLUSIONS: Immunohistochemical detection of hepatic micrometastases is feasible in @entity1 with @entity14 . Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer @entity1 prognosis.
