Impact of @entity2898 and XXXX on Sedation Initiation After Rapid Sequence Intubation.

@entity1 @entity1170 @entity1337 @entity2898 @entity2900
BACKGROUND: @entity1170 ( @entity1170 ) involves a rapidly acting sedative plus a neuromuscular blocking agent (NMBA) to facilitate endotracheal intubation. @entity2898 and @entity2900 are NMBAs commonly used in @entity1170 with drastically different durations of action. OBJECTIVES: Evaluate whether @entity1 receiving @entity1170 with a longer-acting NMBA had a greater delay in sedation or @entity1337 than @entity1 that received a short-acting NMBA. METHODS: This was a retrospective review of @entity1 presenting to the emergency department requiring endotracheal intubation. Exclusions included age < 18 years, pregnancy, prior intubation, and contraindication to sedation and @entity1337 . Primary endpoint was time to continuous sedation or @entity1337 after @entity1170 in @entity1 receiving @entity2898 or @entity2900 . Secondary endpoints included hospital length of stay (HLOS), intensive care unit length of stay (ICU LOS), and impact of an emergency medicine pharmacist (EPh). RESULTS: A total 106 @entity1 met inclusion criteria, 76 @entity1 receiving @entity2898 and 30 receiving @entity2900 . Mean time to sedation or @entity1337 was longer in the @entity2898 group when compared to the @entity2900 group at 34    36 min vs. 16    21 min (p = 0.002). In the presence of an EPh, the mean time to sedation or @entity1337 was 20    21 min, vs. 49    45 min (p < 0.001). Time spent on ventilator, HLOS, and ICU LOS were not significantly different between groups. CONCLUSIONS: @entity1 receiving @entity2898 in @entity1170 had a significantly longer time to sedation or @entity1337 when compared to @entity1 receiving @entity2900 . The presence of an EPh significantly decreased the time to administration of sedation or @entity1337 after @entity1170 .
