Elucidating the Biological Mechanisms Linking XXXX Symptoms With Type 2 Diabetes in @entity1 : The Longitudinal Effects of Inflammation, Microvascular Dysfunction, and @entity251 .

@entity1 @entity32 @entity650 @entity308 @entity251 @entity6 @entity409 @entity164 @entity3800 @entity413
OBJECTIVE: This prospective cohort study sought to examine key biological measures linking @entity308 symptoms with @entity164 2 @entity6 , specifically @entity32 , @entity409 , and @entity3800 . METHODS: A cohort of 688 @entity1 without @entity6 who were 35 years or older were followed up for 5 years. Venous @entity650 , high-sensitivity C-reactive protein, sE-selectin, endogenous total @entity251 , fasting @entity413 , and glycated hemoglobin (HbA1c) were quantified at baseline and 5 years later. @entity308 symptoms were assessed using the Beck @entity308 Inventory-I, and @entity1 were categorized into persistent, remitted, incident, and nondepressed groups (reference). Logistic regression was used to determine odds ratios (ORs) for @entity6 adjusted for propensity score calculated from 18 established risk factors. RESULTS: @entity6 developed in 112 @entity1 (16.3% of sample). Persistent @entity308 symptoms were associated with @entity6 (adjusted OR = 2.45, 95% confidence interval [CI] = 1.16-5.20, p = .019). Baseline @entity251 (OR = 0.43, 95% CI = 0.22-0.81, p = .01) and follow-up @entity251 (OR = 0.51, 95% CI = 0.31-0.84, p = .008) were inversely associated with @entity164 2 @entity6 . Annualized HbA1c was positively associated with annualized change in cognitive Beck @entity308 Inventory symptoms (b = 0.14, p = .001) and inversely associated with annualized change in @entity251 (b = -0.10, p = .014). Annualized change in fasting @entity413 was associated with sE-selectin (b = 0.12, p < .001) and somatic @entity308 symptoms (b = -0.12, p = .002). CONCLUSIONS: The findings suggest that lower endogenous total @entity251 levels and persistent @entity308 symptoms were associated with @entity164 2 @entity6 risk and HbA1c in @entity1 over a 5-year period.
