The effect of intra-articular injection of Diprospan at the knee joint on the XXXX .

@entity1 @entity4545 @entity1887 @entity2339 @entity158
QUESTIONS UNDER STUDY: In this work we wanted to evaluate the effect of intra-articular injection (IAI) at the knee joint of 1 ml of Diprospan on the @entity2339 . METHODS: Consecutive @entity1 attending the rheumatology or orthopaedic clinic with osteoarthritic knee @entity158 not responding satisfactorily to medical and physical therapy were asked to participate in our study. After consent, @entity1 had ultrasound-guided IAI of 1 ml of Diprospan, containing 2 mg of betamethasone sodium phosphate and 5 mg of betamethasone dipropionate. Demographic, clinical, laboratory and radiographic variables were documented. Just prior to the knee injection and 1, 2, 4 and 6 weeks later, @entity1 had a 1-  g @entity4545 (ACTH) stimulation test. @entity1887 ( @entity1887 ) was defined as a poststimulation (30 minutes after ACTH injection) serum cortisol level of less than 18   g/dl (~500 nmol/l) and lack of a rise of >6   g/dl (~166 nmol/l) over the basal level in poststimulation serum cortisol. RESULTS: Twenty @entity1 completed the study. There were 3 male and 17 female @entity1 , with a mean age of 58.6    9.5 years. Six (30%) @entity1 had evidence of @entity1887 and in five of them it was seen at one time-point, mostly at week 2 after the IAI. In one @entity1 , @entity1887 was prolonged and observed from week 1 to week 4. CONCLUSIONS: IAI at the knee joint of 1 ml of Diprospan was associated with a transient high rate of @entity1887 .
