Contribution of XXXX receptors to attention and episodic spatial memory during senescence.

@entity73 @entity3391 @entity71 @entity179 @entity35 @entity2414 @entity3390
UNASSIGNED: A decrease in @entity3391 receptor (NMDAR) function is associated with age-related @entity73 . However, NMDAR antagonists are prescribed for @entity73 associated with age-related @entity179 , raising questions as to the role of NMDAR activity in cognitive function during aging. The current studies examined effects of NMDAR blockade on cognitive task that are sensitive to aging. Young and middle-age @entity35 were trained on the five-choice serial reaction time task (5-CSRTT) and challenged with @entity3390 (0.025, 0.05, and 0.1mg/kg or vehicle). @entity71 were apparent in middle-age and performance of young and middle-age @entity35 was enhanced for low doses of @entity3390 (0.025 and 0.05). The beneficial effects on attention were reversed by the highest dose of @entity3390 . Older animals exhibited a delay-dependent @entity2414 examined on a delayed-matching to place water maze task. Similarly, a low dose of @entity3390 (0.05mg/kg) impaired performance with increasing delay and aged animals were more susceptible to disruption by NMDAR blockade. Despite @entity3390 @entity2414 , @entity3390 had minimal effects on spatial reference memory. Our results confirm that NMDARs contribute to rapidly acquired and flexible spatial memory and support the idea that a decline in NMDAR function contributes to the age-related @entity73 .
