The effect of XXXX allele variants on performance after cochlear implantation.

@entity1 @entity3492 @entity6363 @entity2319 @entity393
OBJECTIVES/HYPOTHESIS: It has been hypothesized that etiology of @entity393 may serve as an independent variable in performance after cochlear implantation. To test this hypothesis, the authors identified pediatric cochlear implant recipients with @entity3492 ( @entity3492 )-related @entity2319 . The study examines performance outcomes associated with @entity3492 @entity2319 -causing allele variants. STUDY DESIGN: Pediatric cochlear implant @entity1 were screened for @entity3492 allele variants; statistical comparisons were made with prospectively obtained performance measures. METHODS: From 181 @entity1 who participated in a nationwide cochlear implant research program, 122 @entity1 were identified with @entity6363 and invited to participate. Screening for @entity3492 allele variants was completed for 55 @entity1 . The @entity1 were homogeneous with respect to age (8 or 9 y) and age at implant (before age 5 y). All @entity1 have previously undergone a prospective regimented battery of performance measures. RESULTS: Performance measures were compared between 22 @entity1 with and 33 @entity1 without mutations to determine whether @entity3492 status was a significant predictor of cochlear implant outcomes. Reading and cognitive outcomes were significantly dependent on connexin status. The group of @entity1 who tested positive for @entity3492 -related @entity2319 scored significantly higher on a nonverbal cognitive measure, Block Design, and on a measure of reading comprehension. CONCLUSION: The isolated insult to the cochlea created by @entity3492 allele variants allows for preservation of central cognitive function. Better reading performance is seen in @entity1 with @entity3492 -related @entity2319 .
