@entity14257 is associated with plasma XXXX activity and the pressor response to dietary @entity1372 intake in Caucasians.

@entity101 @entity1372 @entity14257 @entity916 @entity560
INTRODUCTION: Concentrations of 1,25-hydroxyvitamin D have been positively associated with dietary @entity1372 and salt sensitivity (SS) of blood pressure (BP), and inversely with plasma @entity916 activity (PRA). We investigated the association between PRA and @entity14257 (25OHD), the most clinically relevant @entity560 metabolite, and whether 25OHD associates with SS of BP in @entity916 phenotypes of @entity101 . METHODS: We performed cross-sectional analyses on 223 Caucasian subjects with @entity101 maintained in high and low dietary @entity1372 balance. Subjects were distinguished as having low- @entity916 (LR) or normal- @entity916 (NR) @entity101 . Multivariable linear regression was used to evaluate adjusted relationships. RESULTS: Increasing 25OHD concentrations were inversely associated with PRA (p < 0.05) on both salt diets. Furthermore, 25OHD was associated with SS of BP in LR @entity101 (b = 0.62, p = 0.04), but not in NR @entity101 (b = 0.06, p = 0.59). In an adjusted multivariable interaction model, @entity916 status (LR vs. NR) was a significant effect modifier of the relationship between 25OHD and SS of BP (p = 0.04). CONCLUSIONS: Our findings suggest that 25OHD is inversely associated with PRA and positively associated with SS of BP in LR @entity101 subjects. These results extend and support prior evidence indicating an interaction between dietary @entity1372 , the RAS, and @entity560 that influences BP in @entity101 .
