Antiurolithiatic activity of Pinus eldarica medw: fruits aqueous extract in XXXX .

@entity10977 @entity3835 @entity1790 @entity460 @entity35
PURPOSE: To evaluate the antiurolithiatic activity of Pinus eldarica fruit on induced @entity3835 @entity1790 in @entity35 . MATERIALS AND METHODS: @entity3835 @entity1790 in @entity35 was induced by administering @entity10977 1% for 30 days via drinking water. The prophylactic and therapeutic groups received P. eldarica fruit extract (500 and 1000 mg/kg/day) as well for 30 days and from the 14th day through the end of the experiment, respectively. The following variables were assessed; urine volume, urinary @entity460 excretion, and crystalluria. Finally, @entity35 ' kidneys were histopathologically examined. RESULTS: The aqueous extract prophylactic treatment (500 mg/kg/day) increased urinary @entity460 excretion. Qualitative analysis of crystalluria and histopathologic examination showed that the administered dose of extract prevented stone formation in the kidneys significantly. The prophylactic treatment did not increase urine volume in comparison with @entity10977 . Stone formation did not decrease in the treatment group. CONCLUSION: This study indicates that P. eldarica fruit extract prevents @entity3835 deposition, without producing diuresis.
