Urokinase receptor and XXXX are regulated by common microRNAs in leukaemia cells.

@entity10431 @entity16105 @entity3052 @entity47582 @entity6991 @entity4732 @entity2290 @entity436
The @entity10431 ( @entity10431 ) focuses @entity2290 proteolytic activity on the cell membrane, promoting localized degradation of extracellular matrix (ECM), and binds @entity4732 ( @entity4732 ), mediating cell adhesion to the ECM. @entity10431 -bound @entity2290 and @entity4732 induce proteolysis-independent intracellular signalling, regulating cell adhesion, migration, survival and proliferation. @entity10431 cross-talks with @entity436 , the receptor for the stroma-derived factor 1 chemokine. @entity436 is crucial in the trafficking of hematopoietic stem cells from/to the bone marrow, which involves also @entity10431 . Both @entity10431 and @entity436 are expressed in @entity3052 ( @entity3052 ), with a lower expression in undifferentiated and myeloid subsets, and higher expression in myelomonocytic and promyelocytic subsets. We hypothesized a microRNA (miR)-mediated co-regulation of @entity10431 and @entity436 expression, which could allow their cross-talk at the cell surface. We identified three miRs, @entity6991 , @entity16105 and @entity47582 , regulating the expression of both @entity10431 and @entity436 in @entity3052 cell lines. Indeed, these miRs directly target the 3'untranslated region of both @entity10431 - and @entity436 -mRNAs; accordingly, @entity10431 / @entity436 expression is reduced by their overexpression in @entity3052 cells and increased by their specific inhibitors. Overexpression of all three miRs impairs migration, invasion and proliferation of myelomonocytic cells. Interestingly, we observed an inverse relationship between @entity10431 / @entity436 expression and @entity6991 and @entity16105 levels in @entity3052 , suggesting their possible role in the regulation of @entity10431 / @entity436 expression also in  vivo.
