A community based primary prevention programme for type 2 XXXX integrating identification and lifestyle intervention for prevention: the Let's Prevent @entity6 cluster randomised controlled trial.

@entity1 @entity165 @entity6
OBJECTIVES: Prevention of type 2 @entity6 (T2DM) is a priority in healthcare, but there is a lack of evidence investigating how to effectively translate prevention research into a UK primary care setting. We assessed whether a structured education programme targeting lifestyle and behaviour change was effective at preventing progression to T2DM in @entity1 with @entity6 . MATERIALS AND METHODS: Forty-four general practices were randomised to receive either standard care or a 6hour group structured education programme with an annual refresher course, and regular phone contact. @entity1 were followed up for 3years. The primary outcome was progression to T2DM. RESULTS: Eight hundred and eighty @entity1 were included (36% female, mean age 64years, 16% ethnic minority group); 131 @entity1 developed T2DM. There was a non-significant 26% reduced risk of developing T2DM in the intervention arm compared to standard care (HR 0.74, 95% CI 0.48, 1.14, p=0.18). The reduction in T2DM risk when excluding those who did not attend the initial education session was also non-significant (HR 0.65, 0.41, 1.03, p=0.07). There were statistically significant improvements in HbA1c (-0.06, -0.11, -0.01), LDL @entity165 (-0.08, -0.15, -0.01), sedentary time (-26.29, -45.26, -7.32) and step count (498.15, 162.10, 834.20) when data were analysed across all time points. CONCLUSIONS: This study suggests that a relatively low resource, pragmatic @entity6 prevention programme resulted in modest benefits to biomedical, lifestyle and psychosocial outcomes, however the reduction to the risk of T2DM did not reach significance. The findings have important implications for future research and primary care.
