How relevant and frequent is the presence of mild XXXX in essential @entity101 ?

@entity1 @entity101 @entity1674 @entity740 @entity177 @entity972 @entity1011 @entity413 @entity165 @entity414
Recent analyses of the influence of renal function on the cardiovascular outcome in essential @entity101 @entity1 have confirmed the relevance of the kidney in cardiovascular prognosis even in the initial stages of @entity177 . The evaluation of renal function in clinical practice is based mainly on the finding of changes in serum @entity1011 , but the estimation of @entity1011 clearance or its determination after 24-hour urine collection is not usually performed. The objective of this study was to analyze the prevalence of mild @entity740 (MCRI) through the determination of @entity1011 clearance in @entity1 with essential @entity101 to reinforce the need to consider using this parameter in daily clinical practice. We analyzed clinical and biochemical data from 2686 essential @entity101 @entity1 referred to our unit from 1979-1999. MCRI was defined as a serum @entity1011 > or =1.5 mg/dL in @entity1 and > or =1.4 mg/dL in @entity1 , or a @entity1011 clearance estimated by the Cockroft-Gault formula or by a 24-hour urine collection of <60 mL/min. A prevalence of MCRI was found in 7.6% according to serum @entity1011 levels. This prevalence increased to 22.3% and 21.5% respectively when the diagnostic criteria for MCRI was the estimation of 24-hour @entity1011 clearance in urine, or its estimation using the Cockroft-Gault formula. When classified by @entity1011 clearance values, @entity1 with MCRI were characterized by older age, elevated systolic blood pressure, higher serum total @entity165 , low-density lipoprotein @entity165 , and @entity1674 , lower levels of high-density lipoprotein @entity165 , higher serum @entity414 , fasting serum @entity413 , serum @entity972 , and higher levels of urinary albumin excretion. In summary, MCRI is more prevalent in essential @entity101 than previously thought, particularly if the estimated @entity1011 clearance is used to define MCRI. The finding of an altered renal function is associated with a significant increase in cardiovascular risk. This fact reinforces the need to pay attention to any of the manifestations of renal damage observed in the usual clinical assessment of any @entity101 @entity1 .
