Cardiovascular risk and @entity62 after endocrine control of XXXX .

@entity1 @entity455 @entity101 @entity699 @entity62
OBJECTIVE: @entity699 ( @entity699 ) is associated with high cardiovascular risk. @entity62 ( @entity62 ) are common on brain magnetic resonance imaging (MRI) in @entity1 with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, @entity62 , neuropsychological performance and brain volume in @entity699 . DESIGN/METHODS: Thirty-eight @entity1 with @entity699 (23 in remission, 15 active) and 38 controls sex-, age- and education-level matched underwent a neuropsychological and clinical evaluation, blood and urine tests and 3Tesla brain MRI. @entity62 were analysed with the Scheltens scale. Ten-year cardiovascular risk (10CVR) and @entity455 ( @entity455 ) were calculated according to an algorithm based on the Framingham heart study. RESULTS: @entity1 in remission had a higher degree of @entity62 than controls and active @entity1 (P<0.001 and P=0.008 respectively), which did not correlate with cognitive performance in any group. @entity62 severity positively correlated with diastolic blood pressure (r=0.659, P=0.001) and duration of @entity101 (r=0.478, P=0.021) in @entity1 in remission.   Both @entity1 groups (active and in remission) had higher 10CVR (P=0.030, P=0.041) and @entity455 than controls (P=0.013, P=0.039). Neither the 10CVR nor the @entity455 correlated with @entity62 , although both negatively correlated with cognitive function and brain volume in @entity1 in remission (P<0.05).   Total brain volume and grey matter volume in both @entity699 @entity1 groups were reduced compared to controls (total volume: active P=0.006, in remission P=0.012; grey matter: active P=0.001, in remission P=0.003), with no differences in white matter volume between groups. CONCLUSIONS: @entity1 in remission of @entity699 (but not active @entity1 ) have more severe @entity62 than controls, positively correlated with diastolic pressure and duration of @entity101 . Ten-year cardiovascular risk and @entity455 appear to be negatively correlated with the cognitive function and brain volume in @entity1 in remission of @entity699 .
