Amelioration by @entity1242 of left XXXX induced by percutaneous transluminal coronary angioplasty: assessment by hemodynamic variables and left ventriculography.

@entity1 @entity308 @entity1242 @entity63 @entity910 @entity2845 @entity661
Increasingly longer @entity661 times during coronary angioplasty can create significant left @entity63 , amelioration of which was attempted in this study using @entity1242 . Hemodynamic variables were assessed during inflation of an angioplasty balloon in the proximal left anterior descending coronary artery of 10 @entity1 . Regional wall motion was assessed by left ventriculography during a @entity661 . @entity1242 (200 micrograms) was then administered intravenously, and hemodynamic and ventriculographic assessments during balloon inflations were repeated. Balloon inflation resulted in a marked increase in left ventricular end-diastolic pressure (from 9.2 +/- 2.1 to 19.4 +/- 2.9 mm Hg) and time constant of left ventricular relaxation (from 44.2 +/- 6.2 to 62.3 +/- 11.3 ms) and a decrease in distal coronary artery perfusion pressure (from 54 +/- 9 to 33.1 +/- 4 mm Hg). Time to onset of angina was 29 +/- 3 seconds and time to @entity308 of 1 mm or greater was 30 +/- 3 seconds. Regional wall motion analysis 30 seconds after onset of @entity661 revealed marked @entity2845 and @entity910 in the anteroapical segments with graduated depression of inferior wall motion, greatest at the apex. After the administration of @entity1242 , @entity661 resulted in a smaller increase in end-diastolic pressure (from 5.0 +/- 2.7 to 8.3 +/- 2.6 mm Hg) and time constant (from 47.9 +/- 4.7 to 54.4 +/- 9.2 ms; both p less than 0.01 versus @entity661 ). Distal coronary artery pressure remained similar to @entity661 (32 +/- 3 mm Hg) despite lower mean arterial pressure (89 +/- 5 mm Hg, p less than or equal to 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
