Harmful drinking in military veterans with XXXX : association with the D2 @entity935 receptor A1 allele.

@entity1 @entity935 @entity167 @entity1005 @entity1633
AIMS: The frequency of the Taq I A alleles (A1 and A2) of the D2 @entity935 receptor ( @entity1633 ) gene was examined in Caucasian @entity1005 ( @entity1005 ) @entity1 and controls. RESULTS: In 91 @entity1005 @entity1 , the frequency of the A1 allele was higher (P = 6.12 x 10(-3)) than in the 51 controls. In the 38 @entity1005 harmful drinkers (>or=60 g @entity167 /day), A1 allelic frequency was higher (P = 3.91 x 10(-2)) than in the 53 non-harmful drinkers (<60 g @entity167 /day), the former being also higher (P = 3.76 x 10(-4)) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on @entity1633 allelic association, the 35 @entity1005 @entity1 with the A1(+) (A1A1, A1A2) allele consumed more than twice the daily amount of @entity167 than the 56 @entity1 with the A1(-) (A2A2) allele (P = 1.94 x 10(-3)). When the hourly rate of @entity167 consumed was compared, A1(+) allelic @entity1 consumed twice the rate of the A1(-) allelic @entity1 (P < 10(-7)). CONCLUSION: The @entity1633 A1 allele was associated with @entity1005 . However, this association was found only in the harmful drinkers. @entity1005 @entity1 with the A1(+) allele consumed more @entity167 than @entity1 with the A1(-) allele. The importance of determining @entity167 consumption in @entity1633 association studies with @entity1005 is suggested.
