Primary XXXX : A Case Report with Review of the Literature.

@entity1 @entity2283 @entity5473 @entity5 @entity5701 @entity1970 @entity2277 @entity16524 @entity2281 @entity320
UNASSIGNED: Primary @entity320 (PRM) is a rare variant of @entity320 . Herein, we describe a case of primary @entity5701 and review the clinicopathological features of previously reported cases of PRMs. A 63-year-old Japanese @entity1 presented with a nonpigmented red granular @entity5 without peripheral pigmented macules on the left heel measuring 21 * 18 mm in size. Light microscopic examination revealed a @entity5 mass composed entirely of polygonal neoplastic cells resembling pulmonary alveoli. @entity5 cells were also discohesive with bizarre nuclei, prominent nucleoli and large hyaline cytoplasmic inclusions. No melanin pigment was present. @entity5 cells were strongly and diffusely positive for @entity2281 , @entity16524 , HMB-45 and @entity2277 , while negative for @entity2283 , @entity1970 and @entity5473 . According to previous reviews, PRM tends to be amelanotic and nodular. @entity2281 protein and @entity2277 stained in all cases contrary to low stainability for HMB-45, which was, by contrast, positive in our case. Prognosis of PRM remains controversial due to the very rare occurrence of this @entity5 and the small number of confirmed cases that have been reported. Recognition of this rare entity is important in clinical practice even for skillful dermatologists to avoid misdiagnosis with the other @entity5 and to determinate the subsequent treatment principles.
