Fc-gamma receptors are not involved in cartilage damage during experimental XXXX .

@entity32 @entity625 @entity571 @entity19 @entity10062 @entity38094 @entity79
OBJECTIVE: Fc-gamma receptors (FcyRs) have been shown to play a crucial role in cartilage degradation during experimental @entity625 . Although most of their effect on cartilage degradation has been attributed to their potential to promote @entity32 in the presence of immunoglobulins, activating FcyRs promote cartilage degeneration in @entity625 ( @entity625 ) independently of the level of @entity32 . This prompted us to investigate, whether FcyRs may also play a @entity571 ( @entity571 )-related cartilage degradation. METHODS: FcyR expression was measured by RT-PCR and @entity10062 in @entity19 cartilage tissue and chondrocytes. Experimental @entity571 was induced by destabilisation of the medial meniscus (DMM) in WT @entity19 and animals lacking either activating (Fc receptor y-chain-deficient) or inhibitory (FcyRIIB-deficient) FcyRs. Cartilage damage was investigated histologically 8 weeks post-surgery by assessing proteoglycan loss and structural damage according to OARSI recommendations. Osteophyte size was measured to investigate alterations in bone turnover. RESULTS: Expression analyses revealed significant levels for all four types of @entity19 FcyRs in @entity19 chondrocytes and cartilage tissue from newborn and 8-week-old @entity19 . Surprisingly, yet, ablation of either activating or inhibitory FcyRs did not affect cartilage @entity79 during @entity38094 -induced @entity571 in @entity19 . CONCLUSION: While FcyRs appear to have a crucial role in cartilage degradation during @entity625 our data indicate that FcyRs do not influence cartilage destruction in experimental @entity571 . This indicates that a certain threshold of @entity32 is a prerequisite for FcyR-induced cartilage destruction in @entity625 .
