Endocrine cell XXXX : a clinicopathological evaluation.

@entity1 @entity5 @entity8703 @entity189 @entity14 @entity694 @entity3270
PURPOSE: Endocrine cell @entity189 , according to the Japanese classification criteria for @entity14 , @entity3270 ( @entity3270 ) and mixed @entity189 (MANEC), as defined in the 2010 World Health Organization (WHO) classification. We retrospectively reviewed the clinical features of @entity1 with these @entity5 diagnosed and treated at our institution. METHODS: The clinicopathological @entity8703 of the colon and rectum diagnosed by neuroendocrine markers from January 2000 to December 2012 were retrospectively evaluated in 12 @entity1 . RESULTS: Surgical specimens were obtained from eight of the 12 @entity1 . MANEC was diagnosed in six @entity1 and @entity3270 in one. One @entity5 was unclassifiable. The @entity5 were not resected in four @entity1 , and all died within 3  months. Of the eight @entity1 who underwent resection, four received an R0 resection, two of whom underwent adjuvant chemotherapy and survived more than 5  years. One @entity1 who underwent an R2 resection and continuous chemotherapy survived for 53  months. One @entity1 with @entity3270 underwent surgery and radiotherapy, and died 17  months later. CONCLUSION: Most endocrine cell @entity694 reviewed were MANECs. Though their prognosis was generally poor, chemotherapy may be effective in some @entity1 .
