Ab1-40 and Ab1-42 plasmatic levels in @entity64 : influence of pre-existing cognitive status and XXXX characteristics.

@entity1 @entity64 @entity455 @entity6 @entity63 @entity303 @entity73
UNASSIGNED: Many @entity64 @entity1 have pre-existing @entity73 . Plasma amyloid b peptides (Ab) - possible biomarkers of Alzheimer's pathology - induce @entity455 . Our objective was to evaluate factors influencing plasma Ab1-40 and Ab1-42 peptides in a cohort of @entity64 @entity1 . In the Biostroke study (ClinicalTrials.gov Identifier: NCT00763217), we collected vascular risk factors, neuroimaging features and biological tests including Ab1-40 and Ab1-42. We used the Informant Questionnaire on @entity73 in the Elderly (IQCODE) to systematically assess the pre-existing cognitive status. Of 403 @entity1 (371 @entity63 ), 25 met criteria for pre-existing @entity303 , 142 for pre-existing @entity73 -no- @entity303 , and 236 had no PCoI. Ab1-42 was independently associated with PCoI (odds ratio 0.973; 95% confidence interval: 0.950-0.996; p=0.024). Factors associated with plasma Ab1-40 were age, smoking and @entity6 . After exclusion of @entity64 , the results remained unchanged, but blood samples taken less than 12 hours after onset were associated with lower plasma Ab1-40. Our results support a dissociated response of the 2 plasma Ab peptides in @entity64 @entity1 , plasma Ab1-40 being involved in vascular aspects whereas Ab1-42 might be involved in neurodegenerative processes.
