Familial Risk of XXXX : A Population-Based Cohort Study 1977-2011.

@entity1 @entity31 @entity29 @entity8787 @entity30
OBJECTIVES: Estimates of familial risk of @entity29 ( @entity29 ), @entity30 ( @entity30 ), and @entity31 ( @entity31 ) are needed for counseling of @entity1 and could be used to target future prevention. We aimed to provide comprehensive population-based estimates of familial risk of @entity8787 . METHODS: The study encompassed the entire Danish population during 1977-2011 (N=8,295,773; 200 million @entity1 -years). From national registries, we obtained information on diagnosis date of @entity8787 (N=45,780) and family ties. Using Poisson regression, we estimated incidence rate ratios (IRRs) of @entity8787 in relatives of @entity8787 cases compared with individuals with relatives of the same type without @entity8787 . RESULTS: The risk of @entity30 was significantly increased in first-degree (IRR, 7.77; 95% confidence interval (CI), 7.05-8.56), second-degree (IRR, 2.44; 95% CI, 2.01-2.96), and third-degree relatives (IRR, 1.88; 95% CI, 1.30-2.71) to @entity1 with @entity30 , and was less pronounced in relatives to @entity31 cases. Likewise, the risk of @entity31 was increased in first-degree (IRR, 4.08; 95% CI, 3.81-4.38), second-degree (IRR, 1.85; 95% CI, 1.60-2.13), and third-degree relatives (IRR, 1.51; 95% CI, 1.07-2.12) of @entity31 cases, and less pronounced in relatives of @entity30 cases. IRRs increased with two or more @entity8787 -affected relatives and were modified by age, with the highest family-related IRR observed in early life. CONCLUSIONS: The risk of @entity8787 is significantly increased in first -, second-, and third-degree relatives of @entity8787 -affected cases, with up to 12% of all @entity8787 cases being family cases. The risk is particularly pronounced in young individuals.
