A new prognostic scale for the early prediction of XXXX recovery mainly based on traditional Chinese medicine symptoms and NIHSS score: a retrospective cohort study.

@entity1 @entity64 @entity6 @entity146 @entity148 @entity392 @entity204 @entity385
BACKGROUND: @entity385 ( @entity385 ) is a common disease, often resulting in @entity204 or disability. Previous studies on prognosis of @entity64 mainly focused on the baseline condition or modern expensive tests. However, the change of clinical symptoms during acute stage is considerably neglected. In our study, we aim to develop a new prognostic scale to predict the 90-day outcome of @entity385 @entity1 . METHODS: In this retrospective cohort study, a secondary data analysis was performed on 489 @entity1 extracted from 1046 @entity1 of 4 hospitals. A new prognostic scale was constructed to predict the recovery of @entity385 mainly based on the National Institutes of Health @entity64 Scale (NIHSS) score, traditional Chinese Medicine (TCM) symptoms _ signs and the changes during the first 3  days of @entity1 in the 3 TCM hospitals. Receiver Operating Characteristic (ROC) curve was used to determine the cutoff point for prediction. In the end, the scale was used to test the outcome of @entity385 @entity1 in Xuanwu hospital. RESULTS: The new prognostic scale was composed of 8 items including age degree (OR   =   3.32; 95  % CI: 1.72-6.42), history of @entity6 ( @entity6 ) (OR   =   2.20; 95  % CI: 1.19-4.08), NIHSS score (OR   =   3.08; 95  % CI: 2.16-4.40), @entity148 (OR   =   3.17; 95  % CI: 1.90-5.29) and @entity146 (OR   =   4.61; 95  % CI: 1.36-15.63) on the 1st day of illness onset, change in NIHSS score (OR   =   2.49; 95  % CI: 1.31-4.73), and circumrotating (OR   =   7.80; 95  % CI: 1.98-30.64) and @entity392 (OR   =   13.25; 95  % CI: 1.55-113.34) during the first 3  days of @entity64 onset. The total score of the scale was 16.5 and the cutoff point was 9.5, which means @entity1 would have poor outcome at 90  days of @entity64 onset if the score was higher than 9.5. The new scale was validated on the data of Xuanwu hospital, and the value of its sensitivity, specificity and overall accuracy were 69.6 %, 83.3 % and 75.0  % respectively. CONCLUSIONS: The 8-item scale, mainly based on TCM symptoms, NIHSS score and their changes during the first 3  days, can predict the 90-day outcome for @entity385 @entity1 while it still needs to be further validated and optimized clinically.
