Importance of extended spatial coverage for quantitative susceptibility mapping of XXXX -rich deep gray matter.

@entity1 @entity6228 @entity353 @entity68
@entity6228 ( @entity6228 ) is an emerging area of brain research with clear application to brain @entity68 studies in deep gray matter. However, acquisition of standard whole brain @entity6228 can be time-consuming. One means to reduce scan time is to use a focal acquisition restricted only to the regions of interest such as deep gray matter. However, the non-local dipole field necessary for @entity6228 reconstruction extends far beyond the structure of interest. We demonstrate the practical implications of these non-local fields on the choice of brain volume for @entity6228 . In an illustrative numerical simulation and then in @entity1 brain experiments, we examine the effect on @entity6228 of @entity353 in each dimension. For the globus pallidus, as an example of @entity68 -rich deep gray matter, we demonstrate that substantial errors can arise even when the field-of-view far exceeds the physical structural boundaries. Thus, @entity6228 reconstruction requires a non-local field-of-view prescription to ensure minimal errors. An axial @entity6228 acquisition, centered on the globus pallidus, should encompass at least 76mm in the superior-inferior direction to conserve susceptibility values from the globus pallidus. This dimension exceeds the physical coronal extent of this structure by at least five-fold. As @entity6228 sees wider use in the neuroscience community, its unique requirement for an extended field-of-view needs to be considered.
