Effects of different peritoneal dialysis fluids on the XXXX /TH2 balance.

@entity1 @entity308 @entity1198 @entity3157 @entity1200 @entity379 @entity880 @entity413 @entity3646 @entity298
BACKGROUND: @entity298 ( @entity298 ) is associated with a @entity308 of T cell function, as suggested by the impaired production of cytokines by Th cells collected from @entity298 @entity1 . Although treatment biocompatibility could be implicated in this @entity1200 , it has been poorly investigated, thus far. Therefore, we undertook a study aiming to analyze the effects of different peritoneal dialysis fluids on the @entity1198 /Th2 balance in @entity298 @entity1 . METHODS: Twenty three @entity1 on continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Seven @entity1 were on CAPD with icodextrin solution (ICO- @entity298 ), seven with @entity413 and @entity880 / @entity3157 -buffered solution (LAC/BIC- @entity298 ), and nine with @entity413 and @entity880 -buffered solution (LAC- @entity298 ). The @entity1198 /Th2 balance was evaluated by measuring @entity379 ( @entity1198 subset) and @entity3646 (Th2 subset), both in circulating and peritoneum-derived Th lymphocytes unstimulated or stimulated by phytohemoagglutinin (PHA). Moreover inflammatory, nutritional and dialysis-related parameters were recorded. Eight normal subjects comprised the control group (CON). RESULTS: Circulating T cells: @entity379 was significantly lower in the LAC- @entity298 group (p<0.05) compared to the ICO- @entity298 and LAC/BIC- @entity298 groups. The @entity379 / @entity3646 -producing cell ratio was significantly lower in @entity298 @entity1 than in CON. Peritoneal T cells: after 24-h PHA stimulation, @entity379 increased in all @entity1 , but the rise was less pronounced in the LAC- @entity298 group (p<0.05) than in the other two @entity298 groups. The @entity1198 /Th2 ratio was significantly lower in the LAC- @entity298 group when compared both to LAC/BIC- @entity298 and ICO- @entity298 groups. In addition, the LAC- @entity298 group presented a significantly higher rate of @entity298 compared to the other @entity298 groups. CONCLUSIONS: CAPD with @entity880 -buffered peritoneal fluid has deleterious effects on the @entity1198 cell subset, while the use of more biocompatible fluids, @entity3157 -buffered and icodextrin, is associated with a more physiologically representative @entity1198 /Th2 balance and a reduced @entity298 rate.
