Failure to achieve euglycemia despite aggressive XXXX control signals abnormal physiologic response to @entity130 .

@entity1 @entity2690 @entity413 @entity130
PURPOSE: We hypothesize that a failure to normalize a @entity1 's @entity413 on an automated euglycemia protocol signals an adverse response after @entity130 and that this response can identify @entity1 with an increased mortality. MATERIALS AND METHODS: There were 1246 ventilated, critically ill @entity130 @entity1 who were placed on an automated euglycemia. All @entity413 values collected both by laboratory serum measurements and by bedside arterial samples were included in the analysis. RESULTS: Forty six thousand two hundred eighteen data entries for @entity413 (mg/dL) were analyzed. Time to normalization, defined as the first value in the goal range of 80 to 110 mg/dL, was different between the 2 groups, survivors correcting significantly faster (396 vs 487 minutes; P = .003). Mortality in @entity1 who normalized (80-110 mg/dL) in the first 6 hours of admission was 13.6% vs 18.3% in @entity1 requiring greater than 6 hours (P = .02). @entity1 who never normalized also required significantly greater @entity2690 doses despite there being no significant difference in demographic data between the 2 groups. CONCLUSIONS: A posttraumatic @entity1 's response to tight glycemic control revealed important prognostic information about the @entity1 ' physiologic status. @entity1 who failed to reach euglycemia in the first 6 hours of admission had an increased hospital mortality. The time to normalization is significantly longer in those @entity1 who died. @entity1 who did not correct rapidly required significantly higher @entity2690 doses, suggesting @entity2690 resistance.
