Comparison of rescue techniques for failed XXXX sedation for magnetic resonance imaging scans-additional @entity22292 vs intranasal @entity6948 .

@entity1 @entity26 @entity8108 @entity933 @entity6948 @entity22292
BACKGROUND: @entity22292 , a commonly used sedative in @entity1 during noninvasive diagnostic procedures, is associated with side effects like prolonged sedation, paradoxical excitement, @entity933 , and unpleasant taste. @entity6948 , a highly selective a-2 agonist, has better pharmacokinetic properties than @entity22292 . We conducted this prospective, double-blind, randomized controlled trial to evaluate efficacy of intranasal @entity6948 with that of a second oral dose of @entity22292 for rescue sedation during magnetic resonance imaging (MRI) studies in @entity1 . METHODS: One hundred and fifty @entity1 (age group: 1-6 months), who were not adequately sedated after initial oral dose of 50 mg  kg(-1) @entity22292 , were randomly divided into three groups with the following protocol for each group. Group C: second oral dose @entity22292 25 mg  kg(-1) ; Group L and Group H: intranasal @entity6948 in a dosage of 1 and 2 mcg  kg(-1) , respectively. Status of sedation, induction time, time to wake up, vital signs, @entity26 saturation, and recovery characteristics were recorded. RESULTS: Successful rescue sedation in Groups C, L, and H were achieved in 40 (80%), 47 (94%), and 49 (98%) of @entity1 , respectively, on an intention to treat analysis, and the proportion of @entity1 successfully sedated in Group H was more than that of Group L (P    0.01). There were no significant differences in sedation induction time; however, the time to wake up was significantly shorter in Group L as compared to that in Group C or @entity8108 (P < 0.01). No significant adverse hemodynamic or hypoxemic effects were observed in the study. CONCLUSION: Intranasal @entity6948 induced satisfactory rescue sedation in 1- to 6-month-old @entity1 during MRI study, and appears to cause sedation in a dose-dependent manner.
