High intensity focused ultrasound for the treatment of XXXX : early United States clinical experience.

@entity1 @entity1067 @entity13426
High intensity focused ultrasound via a transrectal approach was used to treat 15 @entity1 with symptomatic @entity1067 . The first 10 of these 15 @entity1 underwent continuous temperature monitoring of the periprostatic region throughout the treatment. @entity1 undergoing transperineal thermocouple placement for the purpose of thermometry were treated while under general or spinal anesthesia, whereas 4 of the 5 remaining @entity1 were successfully treated using intravenous sedation alone. Of the 10 @entity1 9 did not demonstrate a significant temperature elevation. One @entity1 with a small prostatic anteroposterior diameter had a transient elevation of 17C. No @entity1 experienced a complication related to periprostatic heating. Followup was available at 90 days in all @entity1 . At 90 days the symptom scores decreased from a pretreatment value (American Urological Association questions 1 to 7) of 31.2 (range 22 to 38) to 15.8 (range 8 to 31). Peak flow rate increased by a mean of 4.7 ml per second from 9.3 ml per second before treatment to 14.0 ml per second at 90 days. The most frequent complication was that of transient urinary retention in 11 of 15 @entity1 (73.3%) and @entity13426 in 7 (46.7%). No adverse reactions persisted at 90 days. This study represents an initial attempt using high intensity focused ultrasound to treat symptomatic @entity1067 . Overall, the safety and effectiveness of high intensity focused ultrasound demonstrated in this pilot study are encouraging.
