Thrombolysis for acute XXXX by tenecteplase in the emergency department of a Moroccan hospital.

@entity1 @entity731 @entity1410 @entity385
INTRODUCTION: Thrombolysis has radically changed the prognosis of acute @entity385 . Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase. METHODS: We conducted an open prospective study of all @entity1 who were treated with Tenecteplase for an acute @entity385 admitted to our emergency department. Tenecteplase was administered intravenously at a dose of 0.4 mg/kg single bolus. The primary outcome measure was the proportion of @entity1 achieving significant early neurological recovery defined as an improvement of 4 or more points on the NIHSS score at 24h. RESULTS: 13 @entity1 had been treated by intravenous thrombolysis. 31% were @entity1 . Mean age was 63 years old. The mean NIHSS score at admission was 14.3 and 24h after was at 9.1. The right middle cerebral artery was involved in 69% of cases. The carotid @entity731 was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. One @entity1 presented a capsulo-lenticular @entity1410 of 5 mm(3) in the same side of the @entity385 . CONCLUSION: Tenecteplase is a more interesting thrombolytic than alteplase, it seems to be more suitable for thrombolysis in our center.
