Fresh frozen plasma reduces thrombin formation in newborn XXXX .

@entity1 @entity10647 @entity1003 @entity6343 @entity715
BACKGROUND: Newborn @entity1 undergoing intensive care are at risk of bleeding and @entity715 . Fresh frozen plasma (FFP) is used in hope of preventing these complications, despite poorly defined effects on the coagulation system and lack of proven clinical efficacy. OBJECTIVES AND METHODS: We prospectively evaluated @entity1003 and the effect of standardized amount of FFP transfusion (10 mL kg-1 + 4 mL in 2 h) on various coagulation markers in 33 newborn @entity1 during the first 24 h of intensive care. RESULTS: Increased levels of prothrombin fragment @entity6343 , @entity10647 ( @entity10647 ), and d-dimer were found prior to the transfusion in 97%, 81%, and 100% of the @entity1 , respectively. FFP transfusion was associated with a decrease in @entity6343 level in 26/32 (81%) of the @entity1 . The extent of @entity6343 decrease correlated with the pretransfusion @entity6343 level (R = 0.65, P < 0.0001). The @entity1 series was divided into two groups according to increasing pretransfusional @entity6343 level: Group 1 (preFFP @entity6343 > or = 2.35 nm, n = 16), Group 2 ( @entity6343 <2.35 nm, n = 16). In Group 1, @entity6343 decreased on average 1.58 nm (P < 0.01) from the baseline during FFP transfusion but no significant change in the level of @entity6343 during the transfusion was observed in Group 2. Pretransfusional levels of individual factors or prothrombin time (PT) did not correlate with the FFP-associated decrease in @entity6343 level. CONCLUSIONS: In the @entity1 with the highest pretransfusional thrombin formation, FFP had an acute thrombin-reducing effect. Pretransfusion thrombin generation markers, rather than PT or individual pro- and anticoagulants, may be helpful in identifying the @entity1 who will have measurable coagulational effects induced by FFP.
