Evaluation of serum XXXX , sialyltransferase and sialoproteins in @entity1697 .

@entity1 @entity3167 @entity1697 @entity5 @entity1613
OBJECTIVE: Altered glycosylation of glycoconjugates is among the important molecular changes that accompany malignant transformation. The aim of our study was to investigate clinical usefulness of circulatory levels of @entity3167 , sialoproteins and sialyltransferase for early diagnosis and management of @entity1697 ( @entity1697 ) @entity1 . MATERIALS AND METHODS: Blood samples collected from 210 untreated @entity1697 @entity1 , 100 @entity1 with @entity1613 ( @entity1613 ) and 100 healthy males. @entity1697 @entity1 were followed after initiation of anticancer treatment and 394 follow-up samples were also collected. Serum @entity3167 levels were measured spectrophotometrically. Sialyltransferase activity was analysed using radioassay. Alpha 2-6 sialoproteins were isolated using lectin affinity chromatography. RESULTS: Serum levels of free, protein bound and total @entity3167 as well as their ratio with total proteins were significantly elevated in untreated @entity1697 @entity1 compared with healthy individuals, @entity1 with @entity1613 as well as complete responders (CR). Levels of the markers were comparable between untreated @entity1697 @entity1 and non-responders. We observed positive correlation between serum levels of the markers and extent of @entity5 . Serum sialyltransferase activity showed significant elevations in @entity1697 @entity1 compared with the controls (P<0.001), @entity1 with @entity1613 (P<0.05) and CR (P<0.05). Higher @entity3167 levels in @entity1697 @entity1 at the time of diagnosis showed poor survival. The changes in serum proteins with terminal alpha 2-6 @entity3167 correlated well with the alterations in the levels of @entity3167 forms and sialyltransferase activity. CONCLUSION: Our results confirmed the elevations in @entity3167 and sialyltransferase levels in @entity1697 @entity1 and suggested potential utility of these parameters in prognostication and treatment monitoring of this @entity5 . The alterations in these parameters in circulation were in accordance with the changes in alpha 2-6 sialylated proteins.
