XXXX ( @entity657 / @entity657 ) in experimental @entity792 .

@entity7320 @entity3037 @entity657 @entity11570 @entity35 @entity792
@entity792 ( @entity792 ) is characterized by an interstitial mononuclear cell infiltrate and a severe lesion of seminiferous tubules with germ cells that undergo apoptosis and sloughing. The mechanism by which immune cells migrate and extravasate in the testicular interstitium is poorly understood. The aim of this study was to detect the variations in the expression of @entity657 ( @entity657 / @entity657 ) and its receptor in the testis of @entity35 undergoing @entity792 . @entity792 was induced in Sprague-Dawley adult @entity35 by active immunization with an emulsion of testicular homogenate and complete Freund adjuvant using @entity7320 as co-adjuvant. Control @entity35 injected with saline and adjuvants and normal untreated @entity35 were also studied. By ELISA we observed a significant increase of @entity657 in the testicular fluid (TF) and in the conditioned medium obtained from cultures of testicular macrophages of @entity35 with @entity792 compared with control groups. By immunohistochemistry, an increase in @entity657 expression was observed in mononuclear, endothelial, Leydig and peritubular cells. @entity657 immunoreactivity was also detected in Sertoli cell cytoplasm of @entity35 with severe @entity11570 . A 2-fold increase in the number of mononuclear cells that express @entity3037 was also found in @entity35 with @entity11570 compared with controls. In conclusion, we demonstrated in vivo that @entity657 is highly expressed in testicular interstitial cells suggesting that this chemokine has an important role in recruiting immune cells to the testis in @entity35 undergoing @entity792 .
