Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of XXXX .

@entity1433 @entity64 @entity63 @entity2500 @entity73 @entity1432 @entity148 @entity35 @entity385
UNASSIGNED: The present study was designed to evaluate the beneficial effects of Withania somnifera (WS) pre-supplementation on @entity2500 ( @entity2500 ) model of @entity385 . @entity385 was induced in the @entity35 by inserting intraluminal suture for 90  min, followed by reperfusion injury for 24  h. The animals were assessed for locomotor functions (by neurological deficit scores, narrow beam walk and rotarod test), cognitive and @entity148 -like behavioural functions (by morris water maze and elevated plus maze test). @entity2500 animals showed significant @entity73 . Neurobehavioural changes were accompanied by decreased acetylcholinesterase activity, increased oxidative stress in terms of enhanced lipid peroxidation and lowered @entity1432 levels in the @entity2500 animals. In addition, @entity2500 animals had @entity385 and the presence of pycnotic nuclei. Single-photon emission computerized tomography (SPECT) of @entity2500 animals revealed a @entity385 as a hypoactive area. On the other hand, pre-supplementation with WS (300  mg/kg body weight) for 30  days to @entity2500 animals was effective in restoring the acetylcholinesterase activity, lipid peroxidation, @entity1433 and attenuated @entity2500 . WS significantly reduced the @entity385 and ameliorated histopathological alterations. Improved blood flow was observed in the SPECT images from the brain regions of @entity63 @entity35 pre-treated with WS. The results of the study showed a protective effect of WS supplementation in @entity385 and are suggestive of its potential application in @entity64 management.
