Creatinine-based equations for the adjustment of drug dosage in an XXXX population.

@entity1 @entity28
AIM: For drug dosing adaptation, the KDIGO guidelines recommend using estimated glomerular filtration rate (eGFR) with the CKD-EPI equation, after de-indexation to the body surface area (BSA). In pharmacology, the Cockcroft _ Gault (CG) equation is still recommended to adapt drug dosage. In the context of @entity28 , adjusted ideal body weight (AIBW) is sometimes preferred to actual body weight (ABW) for the CG equation. The aim of our study was to compare the performances of the different GFR estimating equations non-indexed or de-indexed by BSA for the purpose of drug-dosage adaptation in @entity28 @entity1 . METHODS: We analysed data from @entity1 with a body mass index (BMI) higher than 30 kg/m(2) who underwent a GFR measurement. eGFR was calculated with the CKD-EPI and MDRD equations,    de-indexed    by BSA, and the CG equation, using either ABW, AIBW or lean body weight (LBW) for the weight variable and compared with measured GFR, expressed in ml/min. RESULTS: In our population of @entity28 @entity1 , using the AIBW instead of the ABW in the CG equation, markedly improved the overall accuracy of this equation (57% for CGABW and 79% for CGAIBW (p   <   0.05)). For high BMI (over 40kg/m(2) ), accuracies of the CG equations are not different when using LBW than when using AIBW. The MDRD and CKD-EPI equations deindexed by the BSA also displayed good performances with an overall higher accuracy for the MDRD deindexed equation (80% and 76% respectively (p   <   0.05)). CONCLUSIONS: De-indexed MDRD appear the most suitable to estimate non-indexed GFR for the purpose of drug dosage adaptation in @entity28 @entity1 .
