Amelioration of persistent left ventricular function impairment through increased plasma XXXX levels following @entity583 .

@entity1 @entity296 @entity270 @entity5721 @entity301 @entity620 @entity409 @entity583 @entity9050
PURPOSE: @entity301 ( @entity301 ) has been demonstrated to reduce mortality and morbidity and thereby improve the prognosis of @entity1 undergoing acute @entity583 (AMIs). However, this procedure paradoxically increases the initial damage as the result of a condition known as ' @entity296 '. Oxidative stress may contribute to the mechanism of this injury. The goal of the present study was to ascertain whether high plasma @entity9050 levels could ameliorate the reperfusion injuries that occur after the successful restoration of blood flow. METHODS: @entity1 from three clinical centers of the public health system were included in the study. The groups were formed by either-sex @entity1 with a diagnosis of ST-segment elevation @entity583 with an indication for primary @entity301 . Only the @entity1 who presented with their first @entity583 were enrolled. @entity9050 was administered through an infusion given prior to the restoration of the coronary flow, which was then followed by oral treatment with @entity620 (500   mg/12   hours) plus @entity270 (400   IU/day) for 84 days. The left ventricular ejection fraction (LVEF) was determined by using cardiac magnetic resonance on days 6 and 84 following the onset of the reperfusion. In addition, the microvascular function was assessed by an angiographic evaluation using the Thrombolysis In @entity583 (TIMI) myocardial perfusion grade (TMPG). The results were grouped according to the plasma @entity9050 concentration achieved immediately following the onset of reperfusion into either the HA group (high @entity9050 , >1   mmol/l) or the LA group (low @entity9050 , <1   mmol/l). The biochemical parameters were analyzed throughout the protocol. RESULTS: The LVEF of the HA group was significantly higher than that of the LA group, values on day 84 in the HA group were 33% higher than those of the LA group. The amelioration of the LVEF was accompanied by an improvement in the @entity409 , after @entity301 , 95% of the @entity1 in the HA group achieved a TMPG of 2-3, in the LA group only 79% of @entity1 showed a TMPG of 2-3. CONCLUSIONS: These data are consistent with the protective effect of high plasma levels of @entity9050 against the oxidative challenge caused by @entity5721 in @entity1 subjected to @entity301 following an AMI. Further studies are needed to elucidate the mechanism accounting for this beneficial antioxidant effect.
