Failure of @entity1242 introduced after prolonged myocardial ischemia to improve collateral blood flow and function in tranquilized XXXX .

@entity296 @entity63 @entity235 @entity1242 @entity1563 @entity1188 @entity432 @entity11608
This study investigated whether @entity1242 can improve @entity63 zone blood flow and function when its infusion is delayed following left anterior descending (LAD) occlusion. @entity1242 (200 micrograms/min, 11 @entity235 ) or saline (six @entity235 ) was infused for 2 hours starting 2 hours after occlusion. Regional @entity296 ( @entity296 ) was measured (9 +/- 1 micron radioactive microspheres) before and at 2 and 4 hours after occlusion. Segmental contraction was determined by cineroentgenography of implanted @entity11608 markers. For all @entity63 samples (defined as @entity296 less than or equal to 0.4 ml/min/gm), the average improvement in @entity296 in the epicardial half (EPI) was 0.05 +/- 0.02 ml/min/gm (mean +/- SEM) with @entity1242 vs 0.06 +/- 0.06 with saline (p greater than 0.5). Improvement in the endocardial half (ENDO) averaged 0.03 +/- 0.03 ml/min/gm with @entity1242 vs 0.09 +/- 0.08 with saline (p = 0.5). Contraction in the @entity63 zone ceased following occlusion and was unaffected by @entity1242 or saline. Control blood flows in the @entity63 region were 22% less in the ENDO (p less than 0.001) and 19% less in the EPI (p less than 0.005) than in nonischemic myocardium. These results indicate that 2 hours after @entity432 in @entity235 , @entity1242 was unable to improve @entity63 zone collateral flow or contractile function compared to untreated controls. Lower @entity63 zone control flows indicate that @entity1188 volume expansion may occur within 4 hours after @entity1563 .
