Alterations in local cerebral @entity413 utilization in XXXX after chronic amphetamine administration without subsequent challenge.

@entity2254 @entity146 @entity35 @entity413 @entity897
The @entity897 (2-DG) method was used to study regional metabolic changes in @entity35 following chronic @entity2254 treatment without subsequent challenges. Four groups of @entity35 were pretreated (intraperitoneal administration) with @entity2254 (0, 1, 5, or 10 mg/kg) once per day for 14 days. After a 7-day abstinence period without further challenge, the 2-DG method was used to measure the rates of local cerebral @entity413 utilization (LCGU). Significant metabolic changes among the four groups were found in five brain regions, including the nucleus accumbens and the lateral habenular nucleus. Another four groups of @entity35 with the same pretreatment regimens, challenged with 5 mg/kg @entity2254 , were used for behavioral testing. The results showed intense @entity146 in the 5 mg/kg and the 10 mg/kg groups. In the steady state, however, there were no significant @entity413 utilization changes in the nigrostriatal system, which is thought to be related to @entity146 . During steady state, metabolic changes were found in a limited number of brain regions. No difference in LCGU was found in the sensitization-related regions. Further challenges with stimulants may be necessary to investigate the metabolic responses after sensitization.
