@entity1068 -induced activation of the @entity2339 in a @entity19 model for binge drinking: role of @entity44855 -sensitive gamma aminobutyric acid receptors, tolerance, and relevance to XXXX .

@entity1 @entity44855 @entity1246 @entity19 @entity167 @entity2819 @entity2339 @entity2661 @entity1068
A @entity19 model for binge drinking has been developed in this laboratory, and several aspects of this model have been characterized. Many of the immunosuppressive effects of @entity1068 ( @entity167 ) in this model seem to be mediated by activation of the @entity2339 and consequent increases in the concentration of glucocorticoids, @entity2661 , and perhaps other immunosuppressive mediators. The purpose of the work described here is to examine three important issues regarding the @entity167 -induced neuroendocrine response in this model: 1) Are @entity44855 -sensitive @entity1246 type A ( @entity1246 -A) receptors involved in activation of the @entity2339 by @entity167 ? 2) Does daily administration of @entity167 produce tolerance with regard to activation of the @entity2339 or with regard to suppression of natural killer cell activity? 3) Is the @entity2339 activated by similar blood @entity167 concentrations in @entity1 and in the @entity19 model? @entity44855 , a partial inverse agonist of @entity1246 -A receptors, did not affect @entity167 -induced increases in blood @entity2819 levels. This suggests that @entity44855 -sensitive @entity1246 -A receptors are not involved in @entity167 -induced activation of the @entity2339 and that inhibition of @entity2819 production is not the mechanism by which @entity44855 blocks @entity167 -induced immunosuppression. To evaluate tolerance, @entity19 were given a daily dose of @entity167 (6.5 g/kg by gavage) or vehicle (water) for 10 days. Control groups received vehicle or @entity167 only on the last day of the experiment. At the optimum time after @entity167 administration serum @entity2819 and splenic NK cell activity were measured. The results indicate no significant alterations in the response to @entity167 of @entity19 exposed to @entity167 for 10 days compared to those exposed only once. To compare the @entity2339 response of @entity19 and @entity1 , lower @entity167 dosages than generally used in our model were administered to @entity19 , and the @entity2819 response was compared to published data for @entity1 who had similar ranges of blood @entity167 levels. The results suggest that @entity1 and @entity19 exhibit activation of the @entity2339 only when blood @entity167 levels exceed approximately 0.14%. Together these results further characterize a @entity19 model for binge drinking that seems to provide a reasonable representation of many aspects of binge drinking in @entity1 .
