Metabolism of albumin and XXXX in type 1 (insulin-dependent) diabetes mellitus.

@entity1 @entity2002 @entity8 @entity6 @entity1723
The metabolism of albumin and @entity2002 was studied in 24 long-term @entity1723 (insulin-dependent) @entity1 , using a double tracer technique. The @entity1 were divided into three groups according to their urinary albumin excretion. Group 1 had normal albumin excretion (less than 30 mg/24 h), group 2 had persistent microalbuminuria (30-300 mg/24 h), and group 3 had clinical @entity8 (greater than 300 mg/24 h). Eight normal @entity1 served as control subjects. Except for slightly lower distribution fractions of both proteins (intravascular mass/total mass), group 1 did not differ from normal subjects. In groups 2 and 3 the relative catabolism of albumin was increased, as denoted by an increase in the fractional catabolic rate. Albumin synthesis was unaltered, resulting in lower plasma concentrations and lower intravascular and total body masses of albumin. Oppositely, @entity2002 synthesis was augmented, leading to an increase in plasma @entity2002 concentration and total @entity2002 body mass, in spite of increased catabolism. The fractional catabolic rates were unaltered. The study demonstrates that long-term @entity6 @entity1 with normal urinary albumin excretion have normal albumin and @entity2002 metabolism, but that grave alterations in plasma protein metabolism are present in @entity1 with only slightly increased urinary albumin excretion.
