XXXX : @entity15213 -induced @entity6050 .

@entity1 @entity15213 @entity625 @entity233 @entity2117 @entity16 @entity7889 @entity425 @entity7170 @entity3505 @entity3427 @entity6050
It has been estimated that during 1955-1959 in southeastern @entity233 , approximately 4000 @entity1 developed @entity6050 due to ingestion of @entity15213 ( @entity15213 ), a fungicide added to @entity3505 seedlings. @entity1 subsequently developed bullae on sun-exposed areas, @entity2117 , @entity3427 , @entity425 and porphyrinuria. @entity1 born to mothers who had ingested the grain were exposed to @entity15213 in maternal milk and transplacentally, resulting in the death of @entity1 under the age of two. In this follow-up study, 204 @entity1 with a past history of @entity15213 -induced @entity6050 were re-evaluated. There were 132 males and 72 females, with an average age of 32.1 years, an average age of onset of 7.1 years and a duration of 2.4 years. The clinical features of the 204 @entity1 were: scarring of the face and hands in 86.7%, @entity2117 in 71.1%, @entity3427 in 47.1%, pinched facies in 41.2%, fragile skin in 37.7%, painless @entity625 in 66.6%, small hands in 64.2%, an enlarged liver in 4.4% and an enlarged thyroid in 37.3%; most @entity1 also showed @entity16 . Urine and stool @entity7170 levels were determined in all @entity1 . Seventeen showed elevated levels of one of the @entity7889 and eight were considered still porphyric after 25-30 years. A total of 56 specimens of @entity1 milk obtained from porphyric mothers were analysed for @entity15213 . The average value was 0.51 ppm compared with 0.07 in controls. After @entity15213 ingestion, abnormal @entity7170 metabolism, dermatological, orthopaedic and neurological findings, and @entity15213 residues in the milk of porphyric @entity1 have been shown to persist at least for 25-30 years.
