Parallel development of choroid plexus degeneration and meningeal inflammation in XXXX - experimental study.

@entity410 @entity455 @entity66 @entity63 @entity510 @entity95 @entity3193 @entity1104 @entity2553 @entity528 @entity943 @entity221 @entity2723 @entity386
BACKGROUND: The choroid plexuses (CPs) are brain structures located in the brain ventricles, involved in the production and reabsorption of cerebrospinal fluid (CSF) components, cerebral immune surveillance, and various endocrine-enzymatic activities and acts as a  CSF-blood barrier. This study investigated to determine if there is a  link between @entity63 and meningo-cerebral inflammation processes. MATERIAL AND METHODS: This study was conducted on 18 @entity95 . Four @entity95 were used as the baseline group to examine the normal structures. Fourteen of the @entity95 were used as the study group by injecting 1.00cc of homologous blood into their cisterna magna. The animals were followed by daily monitoring for ten days and then slaughtered. Apoptotic degeneration of the @entity2723 cells was determined and statistical analyses were carried out using normal and apoptotic @entity2723 cell numbers. Data analyses were comprised of Mann-Whitney U  tests. Differences were considered to be significant if p  <  0.005. RESULTS: Five animals belonging to the study group died between the 5th and 8th days. Unconsciousness, neck stiffness, @entity410 , @entity221 , @entity386 , @entity943 , and breathing disturbances were observed in all of the animals who subsequently died. Intraventricular blood leakage was detected in all the dead and three surviving animals. @entity2553 , @entity3193 , @entity66 , pia-arachnoid thickening, @entity1104 and blood cell density in the subarachnoid spaces were more severe in the more @entity528 animals than those of the others. There were significant differences between the apoptotic @entity2723 cell density and blood cell density in the subarachnoid spaces (p  <  0.005). CONCLUSIONS: @entity510 ( @entity510 ) extending to brain ventricles causes @entity63 by way of triggered @entity455 . It should be emphasized that the prevention of @entity2723 function may be an important part of the protection of the brain in @entity510 .
