@entity263 upon combination of hormone ablation therapy and XXXX in vivo.

@entity10178 @entity263 @entity12698 @entity5 @entity19 @entity177 @entity342 @entity1167
BACKGROUND: Hormonal ablation is the standard of treatment for advanced @entity342 -dependent @entity263 . Although @entity5 regression is usually achieved at first, the @entity5 inevitably evolves toward @entity342 -independence, in part because of the development of mechanisms of resistance and in part because at the tissue level @entity342 withdrawal is not fully attained. Current research efforts are focused on new therapeutic strategies that will increase the effectiveness of @entity342 withdrawal and delay recurrence. We used a syngeneic pseudo-orthotropic @entity19 model of @entity263 to test the efficacy of combining @entity342 withdrawal with FDA-approved @entity10178 inhibitor @entity12698 . METHODS: GFP-tagged @entity19 cells were co-implanted with prostate tissue in the dorsal chamber model and @entity5 were allowed to establish and vascularize. @entity5 growth and angiogenesis were monitored in real-time using fluorescent intravital microscopy (IVM). @entity342 withdrawal in @entity19 was achieved using surgical castration or chemical hormonal ablation, alone or in combination with @entity12698 (15   mg/kg, twice daily). RESULTS: @entity12698 alone decreased the growth of @entity263 mostly by inducing @entity177 , which resulted in increased apoptosis. Surprisingly, @entity12698 did not possess significant angiostatic activity. Surgical or chemical castration prevented the growth of @entity263 and this, on the other hand, was associated with disruption of the @entity5 vasculature. Finally, @entity342 withdrawal combined with @entity12698 caused @entity5 regression through decreased angiogenesis and @entity1167 and apoptosis. CONCLUSION: @entity12698 , a relatively safe @entity10178 -selective anti-inflammatory drug, significantly increases the efficacy of @entity342 withdrawal in vivo and warrants further investigation as a complement therapy for advanced @entity263 .
