Safety and efficacy of intra-articular XXXX injection without drainage on @entity190 in total knee arthroplasty: A randomized clinical trial.

@entity1 @entity190 @entity928 @entity1151 @entity1150 @entity927
BACKGROUND: Major @entity190 is unavoidable after primary total knee arthroplasty (TKA). The aim of this study was to determine if @entity927 ( @entity928 ) can reduce major @entity190 following TKA. METHODS: In this double-blind, randomized, placebo-control trial, 60 @entity1 treated with unilateral primary cement TKA between August 1st 2013 and September 30th 2013 were randomized into @entity928 500  mg intra-articular injection without drainage (test group, 30 knees) and 30 @entity1 with saline intra-articular injection (control group, 30 knees). RESULTS: There was a significant @entity190 (560.55  mL) between the groups at postoperative day (POD) 5 (999.22  mL vs. 1559.77  mL, P  =  0.001). The maximum hemoglobin drop was identified at POD 3 (10.51  g/dL vs. 9.10  g/dL, mean difference  =  1.41  g/dL). Also, there was a significant reduction in red blood cell and hematocrit loss (P  =  0.001). The transfusion rates (0% vs. 23.3%, P  =  0.011) and average amount transfused (0.00      0.00 units vs. 0.53      1.04 units, P  =  0.009) were significantly lower in the @entity928 group compared with control group. No significant difference in coagulation marker changes were found between @entity928 and control groups (P  >  0.05), but the D-dimer levels at 3 and 5 days post-TKA were statistically lower in the @entity928 group (P  <  0.05). No significant changes in the rate of symptomatic @entity1150 , @entity1151 , or wound healing problems were noted. CONCLUSIONS: @entity928 treatment without drainage during TKA reduces the amount of blood transfusions required without increasing the rate of adverse events.
