Significance of aberrant (cytoplasmic/nuclear) expression of @entity3546 in XXXX .

@entity5 @entity4910 @entity3546 @entity3017 @entity1412
This study concerns the significance of aberrant (nuclear/cytoplasmic) expression of @entity3546 in @entity3017 ( @entity3017 ). On immunohistochemistry, all seven PBLs examined showed nuclear/cytoplasmic expression of @entity3546 , predominantly in the squamoid corpuscles (SCs). In areas with acinar/ductular differentiation, few @entity5 cells displayed nuclear/cytoplasmic expression of @entity3546 and more than half of the @entity5 cells showed membranous expression. Two out of five (40%) @entity5 examined showed missense mutations in codons 33 and 37 of exon 3 of the @entity3546 gene. No mutation of the @entity1412 ( @entity1412 ) gene was detected in two of the remaining three @entity5 . Amplifiable DNA for @entity1412 analysis was not obtained from the one other @entity5 . Immunoreactivity for @entity4910 , one of the nuclear targets of @entity3546 , was found predominantly in the SCs of the seven @entity5 . In contrast, the Ki-67 labelling index was 2-4% (median 3%) in the SCs and 8-18% (median 12%) in the other areas, indicating a negative correlation with nuclear @entity4910 reactivity. These results imply that in PBLs, nuclear/cytoplasmic accumulation of @entity3546 and overexpression of its target gene @entity4910 are not associated with the induction of @entity5 cell proliferation. Nuclear/cytoplasmic accumulation of @entity3546 may be related to the morphogenesis of the SCs that are considered most characteristic for @entity3017 .
