Salutary effect of pre-treatment with an XXXX inducer on @entity63 reperfusion injury in the @entity35 liver.

@entity4665 @entity5721 @entity63 @entity5 @entity855 @entity5420 @entity4027 @entity1234 @entity14185 @entity35 @entity1589 @entity857 @entity99 @entity1865 @entity130 @entity6953
BACKGROUND: @entity5721 ( @entity5721 ) is a common phenomenon occurring during liver surgery, transplantation, and @entity130 . @entity5721 causes oxidative stress which plays a critical role in causing organ damage. The @entity4027 is the master regulator of numerous genes, encoding antioxidant, detoxifying, and cytoprotective molecules. @entity4027 dysfunction has been implicated in the pathogenesis of several inflammatory disorders, @entity5 , and aging. This study was undertaken to investigate the effect of @entity4027 pathway activator (dh404) on warm liver @entity5721 in a rodent model. METHODS: Ten @entity35 were treated with dh404 or vehicle. Dh404 was dissolved in @entity5420 oil and was given orally (1.5mg/kg) the night before and 5 hours before procedures. @entity35 livers were subjected to 60 minutes of 70% @entity63 followed by 3 hours of reperfusion. Serum ALT and @entity1234 ( @entity1865 ) were determined and liver tissue was processed for histological examination, and determination of apoptosis, @entity1589 ( @entity1589 ) activity, @entity857 / @entity855 ratio, and expressions of @entity4027 , eNOS, anti-oxidant enzymes, and inflammatory mediators. RESULTS: Serum ALT and @entity1865 levels and tissue @entity1589 activity were significantly lower, expression of the anti-oxidant enzyme, glutamate cysteine ligase were significantly higher, whereas expression of @entity14185 and @entity4665 was unchanged in the dh404-treated group. Although the total @entity6953 histology score did not differ significantly, the extent of sinusoidal congestion, vacuolization, and apoptosis was significantly reduced in the dh404 treated compared to the untreated group (P<0.01). CONCLUSIONS: Pre-treatment with dh404 resulted in partial attenuation of @entity99 reperfusion injury in @entity35 .
