Influence of antioxidant effect of XXXX derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in prophylaxis).

@entity63 @entity2041 @entity1234 @entity35 @entity49690
The goal of the study was to monitor the antioxidative effect of @entity49690 derivative in the conditions of @entity63 -reperfusion of @entity35 kidney tissue. The animals were divided by random selection into 5 groups (n = 10). The treated groups were given @entity49690 derivate in peroral doses of 5, 10 and 20 mg/kg in 0.5 % solution of Avicel once a day; the placebo group was given only the solution of Avicel. The last group was an intact group (without @entity63 -reperfusion and without treatment). After conclusion of medication on the 15th day all animals were subjected to kidney tissue @entity63 (60 min.) followed by reperfusion (10 min.). All animals were subsequently exsanquined and single identification of superoxiddismutase, glutathion peroxidase, total antioxidative capacity, and @entity1234 level in the blood were determined. Kidneys were recovered for histopathological examination. A statistically significant decrease of the superoxiddismutase and statistically significant increase of the @entity2041 peroxidase catalytic activity in the treated groups compared to the groups of placebo and intact was discovered. There was also a statistically highly significant increase of total antioxidative capacity in the treated groups compared to the groups of placebo and intact. A statistically significant decrease of @entity1234 level was identified in the treated groups compared to the groups of placebo and intact. The results of biochemical examination show a protective antioxidative effect of @entity49690 derivative. The results of histopathological examination support this assumption.
