Correlation of Ki-67, @entity876 , and @entity42485 immunohistochemical staining and ploidy with clinical and histopathologic features of severely XXXX .

@entity1 @entity2007 @entity1127 @entity1885 @entity189 @entity876 @entity42485 @entity652 @entity694 @entity2513
Variations of Ki-67, @entity876 , and @entity42485 monoclonal antibody reactions in colonic @entity652 may be associated with @entity694 risk. We studied the predictive value of these markers for adverse behavior in severely @entity2513 , such as an associated @entity189 , multiplicity of @entity652 , and subsequent development of @entity652 . For this purpose we compared theclinical, gross, and histologic characteristics of highly dysplastic index @entity1127 in 42 @entity1 with Ki 67, @entity876 , and @entity42485 immunostaining and other molecular markers. @entity1127 were removed endoscopically, and severely @entity1127 were stained immunohistochemically with Ki-67, @entity42485 , and @entity876 protein by the avidin @entity1885 conjugate (ABC) technique. Quantitative DNA (QDNA) was analyzed by computer-assisted image analysis. Ki-67 immunohistochemistry showed reversal of normal distribution of nuclear staining from the normal basal position to the upper third of the colonic crypts. This abnormality of immunostaining in @entity652 was the earliest detected by the panel we used. A statistically significant correlation was seen between @entity189 in the index polyp and polyp size (P = 0.003), sessile morphology (P = 0.037), and villous or tubulovillous histology (P = 0.019). In the index @entity652 , @entity876 positivity was correlated with multiplicity at initial examination (P = 0.053), villous histology (P = 0.053), @entity189 (P < 0.003), and recurrence of @entity2513 (P = 0.025). Although @entity876 positivity and @entity2007 were correlated with @entity189 in the index polyp (P = 0.025), @entity42485 positivity was not. However, @entity42485 positivity in the index polyp was associated with multiplicity of @entity652 (P = 0.04) as well as recurrence of @entity652 (P < 0.024). In conclusion, in addition to the morphologic and histologic markers already known, Ki-67, @entity42485 antibody, and @entity876 protein may be prognostic indicators useful in follow-up of @entity1 with severely @entity2513 . @entity42485 antibody may identify a field defect in above-average-risk @entity652 -bearing @entity1 .
