Purple sweet potato color inhibits endothelial premature senescence by blocking the XXXX inflammasome.

@entity6 @entity5710 @entity19 @entity26 @entity409 @entity3088 @entity16076 @entity3649 @entity65 @entity731 @entity6198
UNASSIGNED: Purple sweet potato color (PSPC), @entity3088 isolated from purple sweet potato, has been well demonstrated for the pharmacological properties. In the present study, we attempt to explore whether the antisenescence was involved in PSPC-mediated protection against endothelium dysfunction in @entity6 ( @entity6 ) and, if involved, what are the possible mechanisms. The results showed that atherogenesis and endothelial senescence in the thoracic aorta were promoted in @entity19 with @entity5710 ; meanwhile, PSPC attenuated the deterioration of vascular vessel and inhibited the endothelial senescence. @entity6 is a documented high-risk factor for the development of @entity731 . Studies show that @entity3649 ( @entity16076 ) promotes endothelial cell senescence in vitro. In our study, we have determined that PSPC could suppress the @entity16076 -induced premature senescence and the abnormal endothelial function, discovered in the early stages of @entity731 induced by @entity6 . We have discovered that the PSPC down-regulates reactive @entity26 species (ROS) accumulation and the @entity6198 inflammasome functions. Furthermore, the premature senescence induced by @entity16076 was inhibited after attenuation of ROS and deactivation of @entity6198 inflammasomes. However, once the @entity6198 inflammasomes are overactivated, PSPC could not restrain cell senescence. These data imply that the beneficial effects of PSPC on @entity6 -induced @entity409 and senescence are mediated through ROS and @entity6198 signaling pathways, suggesting a potential target for the prevention of endothelial senescence-related @entity65 .
