Contribution of @entity11648 to Framingham risk score for identifying subclinical @entity731 in Chinese XXXX .

@entity1 @entity6481 @entity11648 @entity731 @entity65
BACKGROUND AND AIMS: @entity11648 ( @entity11648 ) was demonstrated to be  involved in the occurrence and development of @entity65 ( @entity65 ). The goal of the present study was to investigate the relationship between serum @entity11648 levels and carotid intima-media thickness ( @entity6481 ) in @entity1 with a low-to-moderate @entity65 risk. METHODS AND RESULTS: Subjects with normal kidney function were selected from the Shanghai Obesity Study. Serum @entity11648 levels were determined by sandwich enzyme-linked immunosorbent assay. @entity6481 was measured by ultrasonography. The Framingham risk score (FRS) was used to assess @entity65 risk. A total of 392 @entity1 with low @entity65 risk and 372 @entity1 with moderate @entity65 risk were enrolled. The recognition rate of an elevated @entity6481 was 85.66% with the combination of a moderate @entity65 risk and high serum @entity11648 levels, which was greater than that with either parameter alone (65.44% and 61.03%, respectively). Subjects with high serum @entity11648 levels, and either low or moderate @entity65 risk, were more likely to have elevated @entity6481 than those with low serum @entity11648 levels and low @entity65 risk (P  =  0.014 and 0.001, respectively). The serum @entity11648 levels were independently and positively associated with @entity6481 in subjects with low or moderate @entity65 risk (both P  =  0.007). CONCLUSION: In @entity1 with low-to-moderate @entity65 risk, serum @entity11648 levels were associated independently and positively with @entity6481 . As a complementary index, serum @entity11648 levels strengthen the capacity of the FRS to identify subclinical @entity731 .
