Protective effects of alkaloid extract from Leonurus heterophyllus on @entity2806 reperfusion injury by middle cerebral @entity63 ( XXXX ) in @entity35 .

@entity1 @entity64 @entity2806 @entity63 @entity2500 @entity3542 @entity1507 @entity51 @entity1188 @entity35 @entity1589 @entity528 @entity385
The @entity528 following @entity2806 is a serious risk to @entity64 @entity1 . The aim of this study was to investigate the neuroprotective effects of alkaloid extract from Leonurus heterophyllus (LHAE) on cerebral @entity63 . After 24 h of reperfusion following @entity63 for 2 h induced by @entity2500 ( @entity2500 ), some @entity35 were intraperitoneally administered different doses of LHAE (3.6, 7.2, 14.4 mg/kg, respectively). Neurological examination was measured in all animals. @entity1188 volume, @entity1589 ( @entity1589 ) activity, levels of @entity1507 / @entity3542 metabolite (NO) and apoptosis ratio of nerve fiber in brain were determined. The results showed that LHAE at 7.2 mg/kg or 14.4 mg/kg exerted significantly decreasing @entity51 scores and reducing the @entity1188 volume on @entity35 with focal cerebral @entity63 (p<0.05). At those dose, the @entity1589 content were significantly decreased in ischemic brain as compared with model group (p<0.05). LHAE at 14.4 mg/kg significantly decreased the NO level compared with the model group (p<0.05). In addition, LHAE significantly decreased the apoptosis ratio of nerve fiber compared with the model group (p<0.05). This study suggests that LHAE may be used for treatment of @entity385 as a neuroprotective agent. Further studies are warranted to assess the efficacy and safety of LHAE in @entity1 .
