An 18-year follow-up of overweight and risk of XXXX .

@entity1 @entity101 @entity28 @entity303 @entity195 @entity65
BACKGROUND: Overweight and @entity28 are epidemic in Western societies and constitute a major public health problem because of adverse effects on vascular health. Vascular factors may play a role in the development of a rapidly growing disease of late life, @entity195 ( @entity195 ). Using body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), we examined whether overweight is a risk factor for @entity303 and @entity195 . METHODS: The relationship between BMI and @entity303 risk was investigated in a representative cohort of 392 nondemented Swedish adults who were followed up from age 70 to 88 years, with the use of neuropsychiatric, anthropometric, and other measurements. Multivariate Cox proportional hazards regression analyses included BMI, blood pressure, @entity65 , cigarette smoking, socioeconomic status, and treatment for @entity101 . RESULTS: During the 18-year follow-up (4184.8 risk-years), 93 @entity1 were diagnosed as having @entity303 . @entity1 who developed @entity303 between ages 79 and 88 years were overweight, with a higher average BMI at age 70 years (27.7 vs 25.7; P =.007), 75 years (27.9 vs 25.0; P<.001), and 79 years (26.9 vs 25.1; P =.02) compared with nondemented @entity1 . A higher degree of overweight was observed in @entity1 who developed @entity195 at 70 years (29.3; P =.009), 75 years (29.6; P<.001), and 79 years (28.2; P =.003) compared with nondemented @entity1 . For every 1.0 increase in BMI at age 70 years, @entity195 risk increased by 36%. These associations were not found in @entity1 . CONCLUSIONS: Overweight is epidemic in Western societies. Our data suggest that overweight at high ages is a risk factor for @entity303 , particularly @entity195 , in @entity1 . This may have profound implications for @entity303 prevention.
