Comparison of algorithms for detection of localised nerve fibre XXXX using scanning laser polarimetry.

@entity1 @entity9999 @entity655
AIMS: To evaluate different algorithms used to analyse retinal nerve fibre layer thickness (RNFL) data obtained by scanning laser polarimetry, in order to compare their relative abilities to discriminate between @entity1 with glaucomatous localised nerve fibre @entity655 and normal subjects. METHODS: 48 eyes of 48 glaucomatous @entity1 with localised RNFL defects and 53 eyes of 53 healthy subjects were included in this study. The localised RNFL defects were identified by RNFL photography and/or slit lamp biomicroscopic examination. All @entity1 were submitted to RNFL examination using scanning laser polarimetry ( @entity9999 nerve fibre analyser, Laser Diagnostic Technologies, Inc, San Diego, CA, USA). Three methods of analysis of polarimetry data were used: @entity9999 software provided parameters; RNFL thickness measurements in 16 equal sectors around the optic disc (sectoral analysis); and Fourier analysis of the curve of distribution of RNFL thickness measurements. Linear discriminant functions were developed to assess sensitivity and specificity of the sectoral based analysis and Fourier analysis and were compared to the @entity9999 parameters. In addition, areas under the receiver operating characteristic (ROC) curves were compared. RESULTS: At a fixed specificity of 91%, the sensitivity of the linear discriminant function from sectoral data (LDF sectoral) was 81%, with an area under the ROC curve of 0.93. The linear discriminant function from Fourier measures had a comparable performance, with an area under the ROC curve of 0.93, and sensitivity of 71% for specificity at 91%. At the same specificity, the sensitivities of the @entity9999 software provided parameters ranged from 15% to 40%. The areas under the ROC curves for the LDF sectoral and LDF Fourier were significantly greater than the ROC curve area for the single best @entity9999 parameter. CONCLUSION: The sectoral based analysis and the Fourier analysis of RNFL polarimetry data resulted in an improved detection of eyes with glaucomatous localised nerve fibre @entity655 compared to the @entity9999 software provided parameters.
