Association of Common Variants in XXXX with Keratoconus: A Meta-Analysis.

@entity16911 @entity71557 @entity12553 @entity71554 @entity71556 @entity71555 @entity9042
BACKGROUND: Several case-control studies have been performed to examine the association of genetic variants in @entity12553 oxidase ( @entity16911 ) with @entity9042 . However, the results remained inconclusive and great heterogeneity might exist across populations. METHOD: A comprehensive literature search for studies that published up to June 25, 2015 was performed. Summary odds ratios (OR) and 95% confidence intervals (CI) of each single nucleotide polymorphism (SNP) were estimated with fixed effects model when I2<50% in the test for heterogeneity or random effects model when I2>50%. Publication bias was evaluated using funnel plots and Egger's test. RESULTS: A total of four studies including 1,467 @entity9042 cases and 4,490 controls were involved in this meta-analysis. SNPs @entity71554 and @entity71555 showed significant association with @entity9042 , with ORs of 0.71 (95% CI: 0.63-0.80, P = 1.43E-08) and 0.77 (95% CI: 0.61-0.97, P = 0.026), respectively. In contrast, our study lacked sufficient evidences to support the association of @entity71556 / @entity71557 with @entity9042 across populations. CONCLUSION: This meta-analysis suggested that two @entity16911 variants, @entity71554 and @entity71555 , may affect individual susceptibility to @entity9042 , while distinct heterogeneity existed within this locus. Larger-scale and multi-ethnic genetic studies on @entity9042 are required to further validate the results.
