Relationship between Serum Gamma-glutamyl Transferase Levels with Ascending XXXX .

@entity1 @entity15533 @entity384 @entity101
OBJECTIVE: Increased serum gamma-glutamyl transferase levels ( @entity15533 ) have been shown to directly promote oxidative stress. Previous studies have shown the relationship between the dilatation of the ascending aorta and oxidative stress. This study was designed to examine the relationship between serum @entity15533 concentrations with dilatation of the ascending aorta. MATERIALS AND METHODS: Ninety @entity1 with ascending @entity384 and 90 age-sex-matched @entity1 without @entity384 were included in the study. The @entity1 were evaluated by a complete transthoracic echocardiographic examination including measurement of the aortic dimensions, where a diameter of 3.7 cm and above was accepted as ascending @entity384 . Serum @entity15533 concentration was measured in all @entity1 . RESULTS: In the group with @entity384 , @entity101 frequency, serum uric acid, hs-CRP and @entity15533 levels, the LV mass index, and the left atrial volume index were found to be higher than the control group. The logistic regression analysis showed that only @entity101 frequency (OR:1.23, 95% CI 1.11-1.35, p value: 0.02), the LA volume index (OR: 1.34, 95% CI 1.21  1.4, p:0.005) and serum @entity15533 levels (OR: 1.12, 95% CI 1.01  1.20, p:0.03) were found to be independent predictors. There was a significant correlation between serum @entity15533 levels and ascending aortic diameter (r: 0.268, p<0.001). In the ROC curve analysis, AUC was 0.659 (0.580  0.738) for a 23.5 serum @entity15533 cut-off value (64% sensitivity and 53% specificity). CONCLUSION: We found that serum @entity15533 concentration was significantly associated with ascending @entity384 . Large epidemiological studies are required to correlate the findings from this study with clinical outcome.
