Spreading Patterns, Prognostic factors and Treatment Outcomes of @entity4937 and XXXX .

@entity1 @entity129 @entity3975 @entity2347 @entity4937 @entity189 @entity3 @entity420
OBJECTIVES: In this study, we aim to analyze the different spreading patterns, prognostic factors and treatment outcomes of @entity4937 ( @entity4937 ) and @entity189 (NPCs). DESIGN, SETTING AND @entity1 : The current study report on a retrospective analysis of oncologic outcome of 76 pathologically confirmed consecutive cases of @entity420 ( @entity420 ), including 31 @entity4937 , 33 @entity2347 ( @entity2347 ) and 12 @entity3975 ( @entity3975 ). MAIN OUTCOME MEASURE: Overall survival rates (OS) and disease-free survival rates (DFS). RESULTS: In 12 @entity1 with @entity129 , there were @entity2347 (n=9), @entity4937 (n=2) and @entity3975 (n=1) (p=0.016). CT/MRI detected CN involvements were found in 22 @entity1 . Lymph node @entity3 were observed in 25.8% of @entity4937 (n=8), 12.1% of @entity2347 (n=4) and 8.3% of @entity3975 (n=1). Significant differences were observed in 5-year overall survival rates (OS) and disease-free survival rates (DFS) between @entity1 with and without CT/MRI-detected CN involvement (p=0.002 and p=0.002, respectively), and similar results were found between @entity1 with and without lymph node @entity3 (p=0.002 and p=0.018, respectively). In 37 @entity1 with early stage disease (stage I-II), significant differences were observed in 5-year OS and DFS rates between the surgical and non-surgical treated groups (p=0.031 and p=0.012, respectively). In 39 @entity1 with advanced stage disease (stage III-IV), significant or marginally differences were observed in DFS and OS between the chemoradiotherapy group and non-chemoradiotherapy group (p=0.007 and p=0.062, respectively). CONCLUSIONS: @entity2347 has a higher CN invasion than @entity4937 and @entity3975 , and @entity4937 has the highest rate of lymphatic metastases. CT/MRI detected CN involvements and lymph node @entity3 indicate a negative impact on the prognosis. The outcome of surgical @entity1 in our series is encouraging in early stage @entity4937 and NPCs, and chemoradiotherapy may be the optimal treatment for the advanced stage @entity1 . This article is protected by copyright. All rights reserved.
