Association of basal serum @entity251 levels with ovarian response and XXXX outcome.

@entity1 @entity251 @entity3610 @entity46 @entity52
BACKGROUND: To evaluate basal @entity251 (T) levels during follicular phase of the menstrual cycle as a predictor for ovarian response and @entity52 ( @entity52 ) outcome. METHOD: We analyzed data retrospectively from hospital-based @entity52 center including one thousand two hundred and sixty Chinese Han @entity1 under their first @entity52 cycle reached the ovum pick-up stage, without @entity3610 ( @entity3610 ) or @entity46 undergoing long @entity52 protocol. @entity1 were divided into 2 groups. Group 1: @entity1 with diminished ovarian reserve (basal FSH >10 IU/L) (n = 187); Group 2: @entity1 with normal ovarian reserve (basal FSH < = 10 IU/L) (n = 1073). We studied the association of basal T levels with ovarian response and @entity52 outcome in the two groups. Long luteal down-regulation protocol was used in all @entity1 , that is, the gonadotropin releasing hormone agonist was administered in the midluteal phase of the previous cycle and use of recombinant FSH was started when satisfactory pituitary desensitization was achieved. RESULTS: Basal T levels were markly different between pregnant and non-pregnant @entity1 in Group 1; whereas not in Group 2. A @entity251 level of 47.85 ng/dl was shown to predict pregnancy outcome with a sensitivity of 52.8% and specificity of 65.3%; and the basal T was correlated with the numbers of large follicles (> 14 mm) on HCG day in Group 1. Significantly negative correlations were observed between basal T, days of stimulation and total dose of gonadotropins after adjusting for confounding factors in both groups. CONCLUSION: In @entity1 with diminished ovarian reserve, basal T level was a predictor for the number of large follicles on HCG day and pregnancy outcome; but could not in those with normal serum FSH. Basal T levels were associated with both days of stimulation and total dose of gonadotropins, indicating that lower level of T might relate with potential ovarian poor response.
