An economic evaluation alongside a randomized controlled trial evaluating an individually tailored lifestyle intervention compared with usual care in @entity1 with XXXX .

@entity1 @entity753 @entity165
BACKGROUND: Cost-effectiveness analyses provide insight in the use of lifestyle interventions. To evaluate the cost-effectiveness of a lifestyle intervention compared to usual care in @entity1 with @entity753 , 340 @entity1 with @entity753 were randomized to the intervention or control group. LDL @entity165 , quality of life and costs were measured at 0 and 12 months. Cost-effectiveness analyses were performed from a healthcare perspective using bootstrapping techniques. RESULTS: Non-significant decreases in LDL @entity165 and quality of life were found. The mean between-group difference in costs was    -237 (95% CI -1,386 to 130). The incremental cost-effectiveness ratios were 1,729 per 1 mmol/l LDL @entity165 and 145,899 per QALY gained. Assumed that the small non-significant decrease in LDL @entity165 is attributed to the intervention, the probability of cost-effectiveness of the intervention compared to usual care was 91% per 1 mmol/l LDL @entity165 reduction and 75% per QALY gained at a ceiling ratio of    20,000. CONCLUSIONS: The intervention is not cost-effective. TRIAL REGISTRATION: NTR1899, date 07-07-2009.
