XXXX stromal @entity2652 is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.

@entity1 @entity0 @entity2652 @entity5 @entity258 @entity1722
UNASSIGNED: BackgroundMammography screen-detected @entity0 have a better prognosis than predicted from established prognostic markers. A search for additional features that are characteristic for these @entity5 and their prognosis is needed to reduce overtreatment, a recognized challenge in @entity0 @entity1 management today. Here, we have investigated the occurrence and importance of @entity5 @entity2652 .MethodsWe performed a population based retrospective study of @entity0 detected in the Norwegian Breast Cancer Screening Programme in Vestfold County during 2004  2009. In total, 197 invasive screen-detected @entity5 and 75 @entity5 in @entity1 aged 50  69 years were compared with regard to standard clinico-pathological parameters and @entity5 shape, as well as ER, PR, @entity1722 and Ki67 expression. In particular, the presence of elastotic @entity5 was graded on a 4-tiered scale (score 0  3).ResultsScreen-detected @entity5 had a significantly higher content of stromal @entity2652 than @entity5 (p  <  0.001). High content of @entity2652 (score 3) correlated strongly with stellate @entity5 shape, low histological grade, and ER+/ @entity1722 - status. Further, high @entity2652 score was significantly associated with lower Ki67 expression. In survival analyses, cases with high @entity2652 demonstrated increased recurrence free (p  =  0.03) and disease-specific survival (p  =  0.11) compared to cases with @entity258 .ConclusionThere is a strong correlation between the presence of @entity5 shape and mammography detection of @entity0 . To our knowledge, this is the first time @entity2652 has been studied in relation to @entity0 detection method. Presence of @entity2652 is associated with low @entity5 cell proliferation (Ki67) and a good prognosis.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_230.
