@entity30 , XXXX , and normal intestinal lymphocytes express integrins in dissimilar patterns.

@entity1 @entity10483 @entity1075 @entity31 @entity29 @entity1293 @entity30
BACKGROUND/AIMS: The integrin family of adhesion molecules on intestinal lamina propria mononuclear cells (LPMNC) was studied using fluorescence-activated cell cytometry. These molecules are implicated in extravascular cell migration and are important regulators of disease. METHODS: Using fluorescence-activated cell cytometry, B- and T-cell subsets in the intestines of 10 normal @entity1 , 11 @entity1 with @entity30 , and 8 @entity1 with @entity31 were stained with monoclonal antibodies to a panel of integrins. RESULTS: Expression of alpha integrins on CD3+ T cells and @entity1075 + B cells was different in normal and @entity29 LPMNC. @entity31 T cells expressed less @entity10483 and significantly more alpha 2 and alpha 6. There was a difference in @entity1293 expression between LPMNC B cells from @entity30 and normal intestines. Sixteen percent of @entity1075 + LPMNC B cells from Crohn's and 19% of @entity31 LPMNC expressed alpha 2. @entity31 @entity1075 + LPMNC B cells expressed more alpha 5 integrin than normal specimens. CD3+ T cells and @entity1075 + B cells expressed alpha 6 only in @entity31 . @entity31 and @entity30 @entity1075 + LPMNC expressed less @entity1293 , consistent with their reciprocal increases of alpha 5 and alpha 2. A difference in beta 7 (Peyer's patch specific) antigen was observed between @entity29 and normal LPMNC for both CD3+ and @entity1075 + LPMNC. CONCLUSIONS: These findings identify the differences of lymphocyte homing capability in @entity29 and normal intestine.
