Role of XXXX Immunohistochemical Expression in Predicting Aggressive Behavior of Phylloides Tumors.

@entity0 @entity39 @entity5 @entity2282 @entity3
BACKGROUND: Phylloides @entity5 are rare @entity0 with a variable clinical course depending on the @entity5 category. Along with histologic features, the role of immunohistochemical staining has been studied in predicting their behavior. OBJECTIVES: Our aim was to evaluate the role of @entity2282 immunohistochemical staining in predicting survival, recurrence and @entity3 in phylloides @entity5 . We also evaluated correlations of other clinicopathological features with overall and disease-free survival. MATERIALS AND METHODS: @entity2282 expression was studied in 82 phylloides @entity5 divided into recurrent/metastatic and non-recurrent/non-metastatic cohorts. The Chi-square test was applied to determine the significance of differences in @entity2282 expression between outcome cohorts. Uni and multivariate survival analyses were also performed using log-rank test and Cox regression hazard models. RESULTS: All 3 metastatic cases, 5 out of 6 (83.3%) recurrent cases and 37out of 73 (50.7%) non-recurrent and non-metastatic cases expressed significant (2+ or 3+) staining for @entity2282 . This expression significantly varied between outcome cohorts (p<0.03). @entity5 category and histological features including mitotic count and @entity39 correlated significantly with recurrence and @entity3 . A significant decrease in overall and disease free survival was seen with @entity2282 positivity, malignant category, increased mitoses and @entity39 . Neither @entity2282 expression nor any other clinicopathologic feature proved to be an independent prognostic indicator in multivariate analysis. CONCLUSIONS: @entity2282 immunohistochemical staining can be used as a predictive tool for phylloides @entity5 but this expression should be interpreted in conjunction with @entity5 category.
