XXXX of the ampulla of Vater: predictors of survival and recurrence after curative radical resection.

@entity1 @entity5 @entity648 @entity787 @entity3 @entity420
BACKGROUNDS/AIMS: Because of low incidence rates, there have been few reports on the patterns of and risk factors for recurrence after curative resection of the ampulla of Vater (AoV) @entity5 . The aim of this study was to characterize patterns of recurrence and to evaluate risk factors affecting survival rates and recurrence after curative resection. METHODS: Medical records of 181 @entity1 who had undergone pancreaticoduodenectomy with curative intent for AoV @entity420 between December 1994 and March 2010 at Samsung Medical Center were retrospectively reviewed. Factors influencing on overall survival rate, recurrence rates, and recurrence patterns were analyzed. RESULTS: Lymph node @entity3 and high preoperative serum @entity787 ( @entity787 ) level >5 ng/ml were identified as independent factors affecting overall survival (p=0.006, p<0.001, respectively). Among the 181 @entity1 , 69 developed local or distant recurrence within 3 years after curative resection. Lymph node @entity3 , preoperative serum @entity787 level >5 ng/ml, and total @entity648 level >1.5 mg/dl were identified as independent prognostic factors of recurrence after curative resection (p=0.008, p<0.001, p=0.003, respectively). CONCLUSIONS: AoV @entity420 has @entity5 , but still has a high recurrence rate, especially during the first three years after curative radical resection. Therefore, careful follow-up is needed during the first 3 years, especially for the higher risk group. Further study of adjuvant therapy to decrease recurrence after curative resection is now warranted.
