Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of @entity2312 in XXXX with compensated @entity1575 .

@entity1 @entity4559 @entity82 @entity96 @entity409 @entity1575 @entity2312 @entity204
AIM: Primary: to evaluate predictivity of @entity409 ( @entity409 ), @entity4559 ( @entity4559 ), and their ratio assessed by real-time 2D shear wave elastography (RT-2D-SWE) for adverse outcomes ( @entity96 or @entity204 ; "event") in compensated @entity1575 ( @entity1575 ) @entity1 . Secondary: to evaluate ability of these measures to discriminate between cirrhotic @entity1 with/without @entity2312 ( @entity2312 ). METHODS: Predictivity of @entity409 , @entity4559 , and @entity409 / @entity4559 was assessed in a retrospectively analyzed cohort of compensated @entity1575 @entity1 (follow-up cohort) and through comparison with incident @entity1 with decompensated @entity82 (DC) (cross-sectional cohort). Both cohorts were used to evaluate diagnostic properties regarding @entity2312 . RESULTS: In the follow-up cohort (n=44) 18 @entity1 (40.9%) experienced an "event" over a median period of 28 months. @entity409 >= 21.5 kPa at baseline was independently associated with 3.4-fold (95% confidence interval [CI] 1.16-10.4, P=0.026) higher risk of event. Association between @entity4559 and outcomes was weaker (P=0.056), while there was no association between @entity409 / @entity4559 ratio and outcomes. @entity1 with DC (n=43) had higher @entity409 (35.3 vs 18.3 kPa, adjusted difference 65%, 95% CI 43%-90%; P<0.001) than compensated @entity1 at baseline. Adjusted odds of @entity2312 increased by 13% (95% CI 7.0%-20.0%; Plt;0.001) with 1 kPa increase in @entity409 . At cut-offs of 19.7 and 30.3 kPa, @entity409 and @entity4559 had 90% and 86.6% negative predictive value, respectively, to exclude @entity2312 in compensated @entity1 . CONCLUSION: This is the first evaluation of RT-2D-SWE as a prognostic tool in @entity1575 . Although preliminary and gathered in a limited sample, our data emphasize the potential of @entity409 to be a reliable predictor of clinical outcomes and the presence of @entity2312 in @entity1575 @entity1 .
