Proliferative Activity of Myoepithelial Cells in Irradiated XXXX Parotid and Submandibular Salivary Glands.

@entity33 @entity95 @entity1358 @entity12914 @entity9236
BACKGROUND: The behavior of salivary @entity1358 ( @entity1358 ) during chronic irradiation exposure is unknown. This study aimed to investigate the response of @entity1358 to prolonged radiation exposure. MATERIALS AND METHODS: 16 @entity95 and four controls were irradiated with either 10 Gy, 20 Gy, 30 Gy or 40 Gy (Gray units) of direct axial beam radiation. Parotid and submandibular glands were removed and examined using immunohistochemical double staining. Proliferating @entity1358 were semi-quantified using alpha smooth muscle actin antibodies and @entity12914 ( @entity12914 ) antibodies. RESULTS: @entity1358 proliferative activity increased after radiation in both submandibular (P = 0.037) and parotid groups (P = 0.006) compared to controls. @entity9236 was seen only in parotid glands which was almost dose-dependent. Mean percentage @entity1358 proliferation did not correlate with the clinical grading or recovery from oral @entity33 (P = 0.47). CONCLUSIONS: Parotid glands are more sensitive to radiation compared to submandibular glands. Further research is needed to determine the role of @entity1358 proliferative activity in response to radiation.
