Liver transplantation with deceased XXXX -incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications.

@entity1 @entity6910 @entity5 @entity1199 @entity2225 @entity618 @entity1140 @entity230
UNASSIGNED: @entity6910 -incompatible (ABOi) liver transplantation (LT) with deceased donor organs is performed occasionally when no @entity6910 -compatible (ABOc) graft is available. From 1996 to 2011, 61 ABOi LTs were performed in Oslo and Gothenburg. Median @entity1 age was 51 years (range 13-75); 33 @entity1 were transplanted on urgent indications, 13 had @entity5 -related indications, and 8 received ABOi grafts for urgent retransplantations. Median donor age was 55 years (range 10-86). Forty-four @entity1 received standard triple immunosuppression with @entity230 , @entity1140 , and @entity618 , and forty-four @entity1 received induction with @entity1199 antagonist or anti- @entity2225 antibody. Median follow-up time was 29 months (range 0-200). The 1-, 3, 5-, and 10-year Kaplan-Meier estimates of @entity1 - (PS) and graft survival (GS) were 85/71%, 79/57%, 75/55%, and 59/51%, respectively, compared to 90/87%, 84/79%, 79/73%, and 65/60% for all other LT recipients in the same period. The 1-, 3-, 5-, and 10-year GS for A2 grafts were 81%, 67%, 62%, and 57%. In conclusion, ABOi LT performed with non-A2 grafts is associated with inferior graft survival and increased risk of rejection, vascular and biliary complications. ABOi LT with A2 grafts is associated with acceptable graft survival and can be used safely in urgent cases. This article is protected by copyright. All rights reserved.
