Treatment failures after antibiotic therapy of uncomplicated XXXX . A prescription database study.

@entity4680 @entity11313 @entity1 @entity293
OBJECTIVES: The efficacy of @entity11313 and @entity4680 in the treatment of @entity293 ( @entity293 ) has been questioned because of an increase in the prevalence of resistant strains. The aim of this study was to describe the risk of treatment failures over the last 10 years. DESIGN: Retrospective cohort study. MATERIAL: Data were retrieved from Odense Pharmaco Epidemiological Database and consisted of @entity1 receiving @entity11313 (n = 44,716) or @entity4680 (n = 3093) during the period 1990-99. MAIN OUTCOME MEASURES: Prescription of a new antibiotic drug appropriate for @entity293 within 4 weeks after the initial treatment was considered as an indicator for a treatment failure. The risk of treatment failure was estimated by calculating the cumulative incidence proportion of new antibiotic prescriptions within 4 weeks after the initial treatment. RESULTS: A new antibiotic followed 8% of @entity11313 and 9.5% of @entity4680 treatments. The cumulative incidence proportion of treatment failures did not change during the study period. A logistic regression model showed @entity4680 to be associated with a higher risk of treatment failure (OR 1.42, CI 1.14-1.77) than @entity11313 . CONCLUSION: This study does not support a change in current Danish practice of @entity11313 being first-line treatment for uncomplicated UVI.
