Sublingual immunotherapy mechanisms of action: the role of XXXX response.

@entity6542 @entity1 @entity13366 @entity1198 @entity56 @entity379 @entity688
@entity6542 ( @entity6542 ) is the only treatment able to modify the natural history of allergic subjects. Several aspects of the immunopathological response modified by @entity13366 ( @entity13366 ), which is an alternative route of administration for @entity6542 , have been investigated. A shift from Th2-polarized immune response toward @entity1198 -oriented pattern has been reported after @entity13366 . More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). @entity56 @entity1 have a defect of Tregs, and @entity13366 should be able to induce a specific Treg response. This issue is very relevant as the Treg-dependent cytokines, namely @entity688 and TGF-beta, are involved in the regulation of IgG and IgA antibodies production. Recent evidence shows that @entity13366 is also able of inducing a Treg response as detected by @entity688 production. @entity379 is a typical @entity1198 -dependent cytokine. @entity13366 may induce a significantly increased production of this cytokine and it may be considered as an early marker of @entity13366 response. Therefore, also @entity13366 is able of exerting the effects on immune response as well as the subcutaneous route.
