Effect of @entity842 donors on XXXX formation and vascular reactivity in the collared carotid artery of @entity95 .

@entity17728 @entity11971 @entity95 @entity1346 @entity12914 @entity842 @entity731 @entity224 @entity8233
Intimal thickening in arteries is considered a site of predilection for @entity731 . We investigated whether oral application of the @entity842 (NO) donors @entity11971 [ @entity11971 , 10 mg/kg body weight twice daily (b.i.d.)] and @entity17728 (10 mg/kg body weight/day) can @entity8233 formation and changes in vascular reactivity induced by a nonocclusive, soft @entity1346 collar positioned around the left carotid artery of @entity95 . The contralateral carotid artery was sham operated and served as a control. Drug and placebo (diet without drug) treatments were initiated 7 days before placement of the collar. At the end of the experiments, two segments were cut from each collared and sham-treated artery, one for measurement of the cross-sectional area of intima and media and the other for isometric tension recording. Sham treatment did not result in intimal thickening in either group. In contrast, the intima/media (I/M) ratio was considerably increased after 14 days of collar treatment as a result of @entity8233 formation. Intimal thickening was significantly inhibited by @entity11971 (I/M ratio 0.05 +/- 0.01 vs. 0.11 +/- 0.02, p < 0.05), but not by @entity17728 (0.06 +/- 0.02 vs. 0.08 +/- 0.02, p = 0.49), which is a donor of both NO and @entity224 anions. Neither collar nor NO donor treatment altered the area of the media. @entity11971 did not alter the percentage of replicating smooth muscle cells (SMC) in the media after collar treatment, as demonstrated by their immunoreactivity for @entity12914 ( @entity12914 ).(ABSTRACT TRUNCATED AT 250 WORDS)
