XXXX as a replacement therapy in hypertension improving quality of life--a multicentre study.

@entity1 @entity3371 @entity591 @entity12833 @entity1296 @entity1338 @entity551 @entity250
A multicentre study was undertaken to determine whether side effects induced by @entity551 drugs could be reduced by replacement with low dose @entity3371 . There were 100 @entity1 on combinations of drugs, including diuretics, beta-blocking agents, @entity12833 , @entity1338 and vasodilators. A questionnarie to obtain information on quality of life was completed by the @entity1 . Each @entity1 had major drugs, possibly responsible for side effects, withdrawn. @entity3371 was added at an initial dose of 12.5 up to 25 mg b.i.d. and titrated to a maximum of 50 mg t.i.d., until the blood pressure was equal to or lower than the level on entry into the study. Blood pressure was measured every two weeks and questionnaries were completed a number of times during the treatment period and scored at random, not in chronological order. A marked drop in blood pressure was obtained: mean systolic blood pressure went down from 173.4 +/- 2 to 154.5 +/- 2 mm Hg and diastolic blood pressure dropped from 104.5 +/- 11 to 9l.5 +/- 12 mm Hg. Neither @entity591 nor orthostasis was observed. Side effects, including inability to concentrate, nightmares, @entity1296 and @entity250 , were reduced in 36% of the @entity1 . @entity3371 itself produced no significant additional adverse reactions. It is concluded that @entity3371 is a safe and effective drug, which can replace antihypertensive drugs that have deleterious side effects.
