XXXX in the management of low cardiac output after open heart surgery.

@entity1 @entity712 @entity772 @entity11073 @entity810 @entity1455
Hemodynamic effects of @entity11073 were studied in 2 groups of @entity1 after open heart surgery. Group I consisted of 10 @entity1 with moderate @entity712 . In the absence of inotropic agents, their mean cardiac index (CI) was 2.02 +/- 0.41 liters/min/m2 and mean pulmonary capillary wedge pressure (PCWP) 19 +/- 3 mm Hg. @entity11073 was administered 24 hours postoperatively by bolus injection (2 mg/kg) and by 12-hour infusions (20 micrograms/kg/min). Hemodynamic data and plasma concentrations were obtained 10 and 20 minutes after the bolus injection and at 1, 4, 8 and 12 hours during infusion. Significant beneficial changes were noted in CI, PCWP, right atrial pressure, systemic vascular resistance and pulmonary vascular resistance. Group II consisted of 5 @entity1 in severe @entity1455 (mean CI 1.97 +/- 0.3 liters/min/m2, mean PCWP 28 +/- 8 mm Hg) despite adrenergic agonists in all @entity1 and intraaortic counterpulsation in 2. After these measures, @entity11073 was given intravenously for 36 to 72 hours as additional inotropic support. Significant improvement was observed in CI, PCWP, right atrial pressure, systemic vascular resistance and pulmonary vascular resistance. Four @entity1 in this group were discharged; 1 @entity1 died after 5 days in @entity810 and @entity772 grade IV. No serious adverse effects of @entity11073 were observed in any group II @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)
