Clinical and histopathological spectrum of XXXX in @entity309 .

@entity1 @entity12288 @entity7674 @entity548 @entity1333 @entity39 @entity1066 @entity1661 @entity3794 @entity12299 @entity4125 @entity3468 @entity5105 @entity11657 @entity194 @entity4216 @entity3144 @entity309
BACKGROUND: Cutaneous manifestations are the most frequent, and often the initial feature of extra-articular involvement in @entity1 with @entity12299 . OBJECTIVES: The purpose of the study was to evaluate the clinical and histological spectrum of @entity1333 and the associated systemic involvement in @entity1 with @entity12299 . METHODS: Among 525 @entity1 with @entity309 , 20 tissue specimens with histologically proven @entity1333 from 11 @entity1 were investigated by studying the types and levels of affected vessels and related clinical features. RESULTS: Small-vessel @entity1333 identified as dermal necrotizing venulitis was found in 10 @entity1 , clinically characterized by palpable @entity4125 , @entity5105 , @entity3144 diutinum and @entity548 . @entity3468 histologically resembling @entity11657 , clinically characterized by subcutaneous nodules, @entity12288 , @entity194 and deep @entity1066 was identified in four @entity1 all with systemic complications. Coexistence of venulitis and @entity3468 was identified in three @entity1 . Different cutaneous vasculitic manifestations often coexisted and recurred in the same @entity1 . Three @entity1 with systemic complications of @entity4216 multiplex (two of three), @entity3794 (two of three) and @entity1661 (one of three) died within 1 year of onset of the @entity1333 . Immunofluorescence demonstrated vessel wall deposition of IgM and/or complement in six of the seven @entity1 examined. CONCLUSIONS: Features of cutaneous @entity12299 overlapping both the characteristics of @entity39 and @entity11657 together with coexistence of these different type of @entity1333 in the same or different lesional skin account for the associated diverse cutaneous vasculitic manifestations. Although @entity7674 ( @entity1333 ) was the most common presentation, the presence of @entity1333 in @entity309 @entity1 did not necessarily indicate a favourable prognosis. Associations with @entity4216 multiplex and bowel involvement had a fatal prognosis, while @entity1 with superficial @entity7674 without other extra-articular involvement may follow a favourable prognosis.
