Randomized, prospective trial comparing 0.2 percent XXXX ointment with sphincterotomy in treatment of @entity12395 : a two-year follow-up.

@entity12395 @entity1241 @entity1 @entity3763
PURPOSE: The aim of this trial was to compare lateral internal sphincterotomy with local 0.2 percent @entity3763 in the treatment of @entity12395 to minimize surgical complications such as minor @entity1241 . METHODS: Fifty-four @entity1 with @entity12395 were randomized in a prospective trial to either sphincterotomy or local 0.2 percent @entity3763 . All @entity1 had anal function tests before and 5 weeks after treatment. RESULTS: In the ointment group, 18 @entity1 (67 percent) healed at 5 weeks and 24 (89 percent) healed at 10 weeks of treatment. Maximum resting anal pressure was reduced 30 percent. Eight @entity1 (30 percent) had minor side effects. In the surgical group, 26 @entity1 (96 percent) healed at 5 weeks and 100 percent healed at 10 weeks after treatment, with 33 percent reduction in maximum resting anal pressure. Forty-four percent of @entity1 had minor @entity1241 , which remained in 15 percent after 24 months follow-up. No statistical difference in maximum resting anal pressure was found between groups ( P = 0.16), but the percentage of healing at 5 weeks was greater in the surgical group ( P < 0.001). CONCLUSIONS: @entity3763 ointment must be considered as the first choice of treatment in @entity1 with @entity12395 . Surgery should be indicated if chemical sphincterotomy fails.
