XXXX and early circulatory cytokine markers.

@entity1 @entity650 @entity137 @entity55 @entity5 @entity651 @entity2842 @entity4105 @entity1207 @entity56 @entity1192 @entity1196 @entity2533 @entity540
@entity1207 is a distinct clinical entity that differs from other pulmonary symptoms such as @entity56 , @entity55 , or @entity55 by various infectious agents. Recent research has supported the mechanism of cellular interaction between lung parenchymal cells and circulating immune cells mediated through a variety of cytokines including proinflammatory cytokines, chemokines, adhesion molecules, and profibrotic cytokines. Identifying reliable biomarkers for @entity1207 will allow us to identify individuals at risk for @entity55 before or during the early stage of therapy. Prospective blood sampling, scoring of respiratory symptoms, and chest imaging were conducted for @entity1 receiving thoracic radiotherapy for @entity5 . Serial plasma specimens were analyzed for circulating cytokine changes before, during, and up to 12 weeks after radiation. @entity1207 was diagnosed using National @entity5 Institute (NCI) common @entity137 criteria. Cytokine analysis was assayed for @entity1192 ( @entity1192 ), @entity650 ( @entity650 ), @entity2842 ( @entity2842 ), @entity4105 , @entity1196 , @entity2533 ( @entity2533 ), and @entity540 ( @entity540 ) using enzyme linked immmunosorbant assay (ELISA). Twenty-four @entity1 had clinical follow-up longer than 12 months after radiotherapy. Thirteen had symptomatic @entity55 (NCI grade 2). The peak incidence of symptoms was between 6 and 13 weeks after radiotherapy. Six @entity1 had only radiographic infiltrates (NCI grade 1). Five @entity1 did not have clinical or radiographic @entity55 . Both @entity1192 and @entity650 levels were significantly higher before, during, and after radiotherapy for those who had @entity55 . The pattern of changes of @entity2842 , @entity4105 , @entity1196 , @entity2533 , and @entity540 varied, but none of these cytokines correlated with @entity1207 . Analysis of a panel of circulating cytokines with different putative functions in radiation @entity651 identified @entity1192 and @entity650 as early circulating cytokine markers for @entity1207 .
