[Development of XXXX in adulthood].

@entity1 @entity5761 @entity410 @entity1032 @entity302 @entity74
INTRODUCTION: @entity5761 ( @entity5761 ) is an @entity302 that starts in childhood and has an unknown pathophysiological mechanism. Studies on the progress of @entity5761 reveal a poor prognosis. @entity1 AND METHODS: A retrospective study of 1629 @entity1 with @entity302 was conducted. @entity1 included in the study were those with an age of onset during childhood, tonic @entity410 and atypical absences (who might also suffer from other types of @entity410 ); electroencephalogram (EEG) showing generalised slow spike-wave and generalised fast activity; @entity1032 and a follow-up time of at least 10 years. RESULTS: The sample consisted of 12 @entity1 , 9 of whom were males. Follow-up time: 20 years. Onset of @entity410 : 3 years. Cryptogenic @entity5761 : 67%; symptomatic: 33%. Frequency of the @entity410 at onset: daily (83.3%) or weekly (16.7%). Types of @entity410 : tonic and atypical absences (100%); drop-attacks (83%); generalised tonic-clonic (75%); myoclonias (41.7%); partial (8.3%) and pseudo- @entity302 (8.3%). EEG with slow background activity, generalised slow spike-wave and generalised fast activity: 100%. Fifty percent of the @entity1 had at least one @entity302 status. They used an average of 7.5 different antiepileptic drugs. At the end of the follow-up 33% were suffering from @entity410 on a daily basis; 17% were weekly and 42% monthly. A total of 8.3% were free from @entity410 . All of them were following combination therapy: 17% in bitherapy and 83% with an average of 3.8 drugs (range: 3-5). A total of 92% suffered from severe or very severe @entity1032 . Fifty percent required neuroleptic drugs due to @entity74 . CONCLUSIONS: Despite the fact that the diagnosis of @entity5761 is serious, we observed a decrease in the number of @entity410 after several years of development, although the antiepileptic combination therapy remains constant. The @entity1032 and @entity74 lead to a poor functional prognosis.
