High-affinity interaction of long-chain fatty acids with serum albumin in XXXX .

@entity1985 @entity1 @entity844 @entity3450
1. We have examined the effect of hypoalbuminaemia, a hallmark of @entity1985 , on the albumin- @entity844 equilibrium in the plasma of 11 adult @entity1 with @entity3450 compared with 12 healthy subjects and six subjects with normoalbuminaemic hyperlipoproteinaemia. 2. We used a dialysis exchange rate method which allows the evaluation in relative terms of the binding affinity of albumin for plasma @entity844 and the @entity844 availability, tentatively equated with the unbound @entity844 fraction. 3. In @entity1985 @entity1 , an increase (P < 0.001) in albumin affinity for @entity844 was seen compared with healthy subjects, which was negatively correlated with albuminaemia (r = -0.69, P < 0.02). No change in @entity844 availability was seen for the group as a whole, but individual values showed a wide scatter, with the highest values in four @entity1 with the highest @entity844 -albumin molar ratios. The increase in albumin affinity for @entity844 was specific to @entity1985 since no such effect was seen in subjects with hyperlipoproteinaemia, who only showed a moderate increase (P < 0.01) in @entity844 availability. 4. The increased albumin affinity for @entity844 in @entity1985 supports the hypothesis that an albumin component with lower affinity for @entity844 might filter out through the diseased glomerular membrane and leave the high-affinity albumin in plasma.
