Effect of @entity8238 inhibition on circadian blood pressure during the development of salt-dependent @entity101 in XXXX .

@entity101 @entity8238 @entity1702 @entity35 @entity15212
UNASSIGNED: A growing body of evidence has indicated that @entity8238 ( @entity8238 ) inhibitors have antihypertensive effects. Here, we aim to examine the effect of vildagliptin, a @entity8238 -specific inhibitor, on blood pressure and its circadian-dipping pattern during the development of salt-dependent @entity101 in @entity1702 ( @entity1702 ) @entity35 . @entity1702 @entity35 were treated with a high-salt diet (8% NaCl) plus vehicle or vildagliptin (3 or 10   mg   kg(-1) twice daily by oral gavage) for 7 days. Blood pressure was measured by the telemetry system. High-salt diet for 7 days significantly increased the mean arterial pressure (MAP), systolic blood pressure (SBP) and were also associated with an extreme dipping pattern of blood pressure in @entity1702 @entity35 . Treatment with vildagliptin dose-dependently decreased plasma @entity8238 activity, increased plasma @entity15212 ( @entity15212 ) levels and attenuated the development of salt-induced @entity101 . Furthermore, vildagliptin significantly increased urine sodium excretion and normalized the dipping pattern of blood pressure. In contrast, intracerebroventricular infusion of vildagliptin (50, 500 or 2500    g) did not alter MAP and heart rate in @entity1702 @entity35 . These data suggest that salt-dependent @entity101 initially develops with an extreme blood pressure dipping pattern. The @entity8238 inhibitor, vildagliptin, may elicit beneficial antihypertensive effects, including the improvement of abnormal circadian blood pressure pattern, by enhancing urinary sodium excretion. @entity101 Research advance online publication, 15 January 2015; doi:10.1038/hr.2014.173.
