Energy expenditure in mechanically ventilated XXXX : The weight of body weight!

@entity1 @entity7493 @entity4629
BACKGROUND _ AIMS: Optimal nutritional care for intensive care unit (ICU) @entity1 requires precise determination of @entity7493 ( @entity7493 ) to avoid deleterious under- or overfeeding. The reference method, @entity4629 ( @entity4629 ), is rarely accessible and inconstantly feasible. Various equations for predicting @entity7493 based on body weight (BW) are available. This study aims at determining the best prediction strategy unless @entity4629 is available. METHODS: Mechanically ventilated @entity1 staying >= 72  h in the ICU were included, except those with contraindications for @entity4629 measurements. @entity4629 and BW measurements were routinely performed. @entity7493 was predicted by the ESPEN formula and other predictive equations using BW (i.e. anamnestic (AN), measured (MES), adjusted for cumulated water balance (ADJ), calculated for a body mass index (BMI) of 22.5). Comparisons were made using Pearson correlation and Bland _ Altman plots. RESULTS: 85 @entity1 (57      19  y, 61 @entity1 , SAPS II 43      16) were included. Correlations between @entity4629 and predicted @entity7493 using the ESPEN formula with different BW (BWAN, BWMES, BWADJ, and BWBMI22.5) were 0.44, 0.40, 0.36, and 0.47, respectively. Bland _ Altman plots showed wide and inconsistent variations. Predictive equations including body temperature and minute ventilation showed the best correlations, but when using various BWs, differences in predicted @entity7493 were observed. CONCLUSION: No @entity7493 predictive equation, regardless of the BW used, gives statistically identical results to @entity4629 . If @entity4629 cannot be performed, predictive equations including minute ventilation and body temperature should be preferred. BW has a significant impact on estimated @entity7493 and the use of measured BWMES or BW BMI 22.5 is associated with the best @entity7493 prediction. Clinical trial registration number on ClinicalTrial.gov: NCT02552446. Ethical committee number: CE-14-070.
