Fine-needle aspiration biopsy of XXXX : a potential false positive pitfall and presence of intranuclear cytoplasmic inclusions.

@entity172 @entity0 @entity39 @entity5 @entity4206 @entity20372 @entity189 @entity4205
Cytologic diagnosis of @entity20372 can be very challenging. We report fine needle aspiration cytology (FNAC) findings of a benign @entity20372 . The cytologic features are characterized by hypercellularity and the presence of numerous atypical dispersed cells with epithelioid morphology and intact cytoplasm. The nuclei showed stippled chromatin, irregular nuclear membrane, and prominent eosinophilic nucleoli. No @entity39 or mitoses were seen. The presence of naked nuclei, and extensive intranuclear cytoplasmic inclusions were identified and raised the possibility of @entity20372 . Immunohistochemically, the atypical cells showed strong positivity for myosin heavy chain, @entity4206 , and @entity4205 , while the epithelial cells reacted with @entity172 receptors. This immunophenotypic pattern supports the myoepithelial origin of the atypical cell proliferation and favors the diagnosis of benign @entity20372 . However, biopsy was recommended to exclude @entity5 . Histologically, the @entity5 showed prominent myoepithelial cells with significant atypia, intranuclear cytoplasmic inclusions, and dense cytoplasm. No evidence of @entity5 was identified. In conclusion, we report a case of @entity20372 with a significant cytological atypia that may result in confusion with @entity0 . The presence of intranuclear cytoplasmic inclusions, naked nuclei, and expression of myoepithelial markers should provide clues to the right diagnosis and benign nature of this lesion. Cytopathologists should be familiarized with this entity to avoid a misdiagnosis of @entity189 .
