Pyostomatitis vegetans associated with XXXX --report of two cases.

@entity500 @entity39 @entity75 @entity31 @entity29 @entity134 @entity74 @entity30
Pyostomatitis vegetans (PV) is a rare, chronic @entity74 associated with @entity29 ( @entity29 ). Oral lesions of PV are distinct and present as multiple white or yellow pustules with an erythematous base that coalesce and undergo @entity39 to form a typical "snail tracks" appearance. Two cases of PV associated with @entity29 --one with @entity30 ( @entity30 ) and the other with @entity31 ( @entity31 ) are reported. In the first case, adalimumab therapy brought the oral and gastrointestinal manifestations to complete remission. In the second case, the remission was achieved with systemic @entity134 therapy, but the disease relapsed after therapy discontinuation. @entity500 was added leading to sustained remission of PV. Because of persistent active intestinal manifestation of @entity31 , in spite of immunosuppressive therapy, infliximab was introduced. With the therapy remission of intestinal manifestation of @entity31 was achieved as well. Our cases confirm previously reported good experience with immunomodulators and biologics in the treatment of PV. But, before using them we have to exclude an infectious etiology of @entity75 .
