Intensified Topical XXXX as Prophylaxis for Macular Edema After Posterior Lamellar Keratoplasty Combined With Cataract Surgery.

@entity1 @entity231 @entity1103 @entity12356 @entity230 @entity479
PURPOSE: To analyze the effect of intensified topical @entity479 therapy after Descemet membrane endothelial keratoplasty combined with @entity231 surgery (triple-DMEK) on the incidence of @entity1103 ( @entity1103 ). DESIGN: Single-center comparative clinical study with historical controls. METHODS: Setting: Department of Ophthalmology, University of Cologne, Germany, tertiary hospital, performing 500 corneal transplant surgeries per year. @entity1 : Total of 131 @entity1 (150 eyes) undergoing triple-DMEK surgery. Inclusion Criterion: Triple-DMEK surgery. EXCLUSION CRITERIA: Prior retinal surgery, history of prior @entity1103 . INTERVENTIONS: @entity12356 eye drops 1% 5 times daily for the first week after surgery. After an internal change of therapy regimen: @entity12356 eye drops 1% hourly for the first postoperative week. We compared 75 consecutive eyes before with 75 consecutive eyes after the change of therapy regimen. @entity1 received macular spectral-domain optical coherence tomography (SD OCT) preoperatively, as well as 6  weeks and 3 and 6  months post surgery. MAIN OUTCOME MEASURE: Development of @entity1103 detected by macular SD OCT during 6  months postoperatively. RESULTS: Both groups were comparable regarding baseline age, sex, central corneal thickness, rebubbling rate, and visual acuity. With topical @entity479 therapy 5 times per day during the first postoperative week, we observed 9 cases of subsequent @entity1103 (12%). With hourly topical @entity479 therapy none of the @entity1 developed @entity1103 subsequently (P  = .003). Apart from the topical @entity230 during the first week, medical treatment was identical in both groups. CONCLUSIONS: Early intensified postoperative topical  @entity479 therapy constitutes an effective prophylactic treatment to reduce incidence of @entity1103 after triple-DMEK surgery.
