Reestablishment of the XXXX to the normal levels seems not to be essential to the anxiolytic-like effect induced by insulin.

@entity35 @entity6 @entity3839 @entity148 @entity209 @entity4854
UNASSIGNED: @entity6 is a chronic @entity209 accompanied by several comorbidities, including neuropsychiatric conditions. Since the @entity4854 appears to be the primary factor involved in @entity6 conditions, we examined the effect of insulin treatment in @entity6 @entity35 on behavioral responses related to @entity148 and aversive memory extinction. For this, normoglycemic (NGL) or @entity3839 - @entity6 (DBT) @entity35 were submitted to the elevated T maze (ETM) and the contextual conditioned fear (CCF) tests. Therefore, animals were subjected to the prolonged treatment with insulin (6  IU/day, s.c.) to investigate the effect of the treatment on distinct behaviors. When @entity148 -like responses such as the inhibitory avoidance (IA) on the ETM and the time of freezing in the first session of the CCF test were evaluated, our data showed a more pronounced anxiogenic-like behavior in DBT animals when compared to NGL ones. In addition, an increased freezing time was observed in DBT animals exposed to the CCF test (sessions 2 and 3) when compared to the NGL group, suggestive of an impairment in the extinction of aversive memory. Insulin treatment induced an anxiolytic-like effect when IA and freezing time (session 1) was evaluated, but did not alter the impaired extinction of aversive memory (sessions 2 and 3). To better understand the involvement of a rigorous control of glycaemia, we also investigated the effect of a lower dose of insulin (3  IU/day, s.c.), unable to reestablish the @entity4854 to the normal levels, on the same behavioral parameters. Our data show that independent of the dose of insulin, the same effects were observed when animals were evaluated in the ETM and CCF tests. However, only the highest dose of insulin was able to reduce the @entity4854 to the normal levels. To conclude, our data suggest that a severe glycemic control by insulin treatment seems to be important, but not essential in improving @entity6 -induced @entity148 .
