Non-histone nuclear factor XXXX as a therapeutic target in colorectal cancer.

@entity5 @entity518 @entity1 @entity3
INTRODUCTION: @entity518 is the focus of recent @entity5 research. @entity518 plays a critical role in @entity5 development, progression, and @entity3 by activation of @entity5 cells, enhancement of @entity5 angiogenesis, and suppression of host anti- @entity5 immunity. @entity518 is a relevant target for @entity5 treatment. AREAS COVERED: This review aims to overview the biological feature and diverses role in @entity5 of @entity518 . @entity518 is a non-histone chromosomal protein, a secretory protein binding to the receptor for advanced glycation end products in @entity5 cells and monocyte-lineage immune cells, and a DNA presenting chaperon for toll-like receptors. @entity518 enhances proliferation, motility, invasion and survival of @entity5 cells. In contrast, @entity518 induces apoptosis in monocyte-lineage immune cells and inhibits @entity5 -infiltrating macrophages and dendritic cells, lymph node sinus macrophages and liver Kupffer cells to attenuate anti- @entity5 immune responses and anti-metastatic organ defense. Then the novel techniques for inhibiting @entity518 are reviewed. EXPERT OPINION: Various techniques targeting @entity518 are subjected to trial. @entity518 targeting is a potential therapeutic techniqueagainst @entity5 development, progression, and especially @entity3 . Technical breakthroughs in application of @entity518 targeting to @entity1 diseases are now urgently required.
