Central nervous system effects of the essential oil of the leaves of Alpinia zerumbet in XXXX .

@entity308 @entity19 @entity3826 @entity148 @entity8364 @entity1767
OBJECTIVES: Alpinia zerumbet, known in Brazil as col  nia, is popularly used as a diuretic, antihypertensive, anti-ulcerogenic and sedative. Based on this, we have investigated the central effects of the essential oil isolated from A. zerumbet leaves. METHODS: @entity19 were treated once with 50 or 100 mg/kg of the essential oil, intraperitoneally, 30 min before being submitted to behavioural models of: locomotor activity (open-field), @entity8364 , @entity148 (elevated plus maze), @entity308 (forced swimming test and tail suspension tests) as well as @entity3826 -induced stereotypy. KEY FINDINGS: Results showed a dose-related decrease on locomotor activity and @entity3826 -induced stereotypy. There was a decrease to the order of 55% of the grooming behaviour with both doses studied. The essential oil 100 mg/kg increased cataleptic activity (167%) and the immobility time in the forced swimming and tail suspension tests. Pretreatment with @entity1767 (0.2 mg/kg, i.p.) alone also decreased locomotion, increased cataleptic activity and immobility time in the tail suspension test. No alterations in the elevated plus maze test were registered. CONCLUSIONS: The essential oil of A. zerumbet leaves had depressant and possible antipsychotic activity, since it could reverse the stereotypy induced by @entity3826 , presenting effects comparable with those obtained with @entity1767 treatment.
