Topoisomerase IIalpha expression in XXXX and carcinomas: relationship to @entity5 behavior.

@entity1 @entity2847 @entity5 @entity1943 @entity977 @entity3 @entity1758 @entity2390 @entity652
DNA topoisomerase IIalpha (Topo IIalpha) is a molecular and immunohistochemical marker that indicates proliferation rate and is the target for several antineoplastic agents. The present immunohistochemical study of a large series of surgically removed @entity977 was designed to assess the prognostic significance of Topo IIalpha expression relative to @entity1 age, gender, @entity5 type and size, invasiveness, @entity3 , @entity1758 -labeling index and angiogenesis. Changes of Topo IIalpha expression in the @entity5 treated with @entity2847 and @entity2390 , a long-acting @entity1943 analogue were also investigated. Topo IIalpha immunopositivity was detected only in the nuclei of @entity5 cells. Gonadotroph @entity652 , null cell @entity652 , and ACTH-producing @entity652 had the lowest Topo IIalpha indices, whereas primary @entity977 and silent type 3 @entity652 presented the highest counts. The statistical study demonstrated no significant correlation between Topo IIalpha expression, @entity1 gender, and vascularity. In contrast, significant negative correlation was found between Topo IIalpha expression and @entity1 age. Topo IIalpha expression was significantly higher in @entity3 . A tendency to have higher counts was also observed in microadenomas compared with in macroadenomas. Although Topo IIalpha and @entity1758 indices were similar in most @entity5 types, no significant correlation between Topo IIalpha and @entity1758 -labeling indices (r =.16, P =.09) was found. Only non-functioning @entity652 showed positive correlation (r =.41, P =.006) between both proliferation markers. Our results demonstrated a significant decrease in Topo IIalpha index in octreotide-treated, GH-producing @entity652 , compared with untreated @entity5 , but no significant changes were observed in @entity2847 -treated, PRL-producing @entity652 . The present study showed no significant advantage of Topo IIalpha over @entity1758 as a prognostic marker; however, Topo IIalpha may provide crucial information regarding selection of @entity977 responsive to antineoplastic therapy, such as invasive @entity977 and @entity977 , which exhibit a high Topo IIalpha index.
