Effect of hypertonic saline solution and dextran on ventricular blood flow and heart-lung interaction after XXXX .

@entity22945 @entity1707 @entity548 @entity1219 @entity1372 @entity299
BACKGROUND: Hypertonic saline solutions may have beneficial hemodynamic effects in the resuscitation of @entity548 . The effects on cardiac function and potential interaction with lung function are controversial and served as the basis for this study. METHODS: Domestic @entity1707 were resuscitated from @entity548 with equivalent @entity1372 loads of lactated Ringer's solution (LR) or 7.5% @entity1219 plus 10% dextran ( @entity22945 ). Hemodynamic data were obtained at baseline, shock, and after resuscitation. Right ventricular ejection fraction and left ventricular change in pressure with respect to time (dP/dt) were used to index contractility. Regional myocardial blood flow was determined with microspheres. Lung water was determined gravimetrically. RESULTS: There were no differences in the ability to restore hemodynamic parameters with equivalent @entity1372 loads of LR and @entity22945 resuscitation. Right ventricular ejection fraction and left ventricular change in pressure with respect to time were only transiently affected by shock and resuscitation. Regional myocardial blood flow was increased above baseline values after @entity22945 . The total resuscitation volumes were 1958 +/- 750 mL and 140 +/- 31 mL with LR and @entity22945 , respectively. CONCLUSIONS: Although LR and @entity22945 were equally effective in the early resuscitation of @entity548 , this occurred at the expense of significantly greater volume requirements for resuscitation with LR. This may contribute to @entity299 in this setting. Enhanced regional myocardial blood flow after @entity22945 resuscitation may be beneficial against ongoing myocardial stress.
