Cervical spine involvement in XXXX over time: results from a meta-analysis.

@entity1 @entity1347 @entity602 @entity309
INTRODUCTION: Complications in @entity309 ( @entity309 ) seem less common than they were years ago. The prevalence and progression of @entity1347 (aAASs), vertical subluxations (VSs), subaxial subluxations (SASs), and associated cervical @entity602 in @entity309 over the past 50 years were determined. METHODS: A literature search was performed by using Medline-OVID/EMBASE, PubMed, and Scopus (from 1960 to June 21, 2014). Prevalence studies were included if the sample size was at least 100 or the prevalence/progression of cervical subluxations was reported. Study quality was assessed by using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Prevalence of cervical subluxations was calculated for each study. Student's t test and meta-regression were used to evaluate for significance. RESULTS: In total, 12,249 citations were identified and 59 studies were included. The prevalence of aAAS decreased from 36% (95% confidence interval (CI) 30% to 42%) before the 1980s to 24% (95% CI 13% to 36%) in the 2000s (P = 0.04). The overall prevalence rates were 11% (95% CI 10% to 19%) for VS, 13% (95% CI 12% to 20%) for SAS, and 5% (95% CI 3% to 9%) for cervical @entity602 , and there were no significant temporal changes. Rates of progression of aAAS, VS, and SAS were 4, 6, and 3 lesions per 100 @entity1 per year, respectively. The incidence of new or progressive cervical @entity602 was 2 cases per 100 @entity1 with known cervical subluxations per year. CONCLUSIONS: Since the 1960s, only aAAS has decreased dramatically. It is still more than twice as common as VS or SAS. No temporal changes in the development of cervical @entity602 in affected @entity1 with @entity309 were noted. The progression rates of cervical subluxations and @entity602 were unchanged over time.
