XXXX in the Pediatric Population: A Case Series and Review of the Literature.

@entity1 @entity1544 @entity981 @entity1583
UNASSIGNED: Blastic plasmacytoid @entity1544 (BPDCN) is a rare aggressive @entity1583 primarily found in adults, often carrying a poor prognosis. There are only 33 reported pediatric cases of BPDCN in the literature. Although standard treatment is not yet established for @entity1 , current literature recommends the use of high-risk @entity981 ( @entity981 )-type chemotherapy. Recent studies, however, have explored the benefits of combining chemotherapy with stem-cell transplantation. Here, the authors present 2 cases of pediatric BPDCN treated with different modalities. The first case is a 13-year-old @entity1 who presented with a 3-month history of an initially asymptomatic firm nodule on her left shin. The second case is a 15-year-old @entity1 who presented with a 4-month history of an enlarging subcutaneous nodule on the lower leg. Immunohistochemical staining of both @entity1 was positive for markers consistent with BPDCN. The latter @entity1 received @entity981 -type therapy alone, whereas the former received @entity981 -type chemotherapy and stem-cell transplantation. Since initial treatment, both @entity1 remain disease-free. These cases contribute to the limited number of pediatric BPDCN cases, thus helping to advance our knowledge toward an optimal treatment protocol for clinical remission.
