XXXX Versus Applied Relaxation for Generalized @entity148 : A Randomized Controlled Study on Clinical and Electrophysiological Outcomes.

@entity1 @entity906 @entity148 @entity308
Some components of generalized @entity148 , such as physical symptoms, are thought to reflect autonomic nervous system arousal. This study primarily assessed the relationships between psychophysiological and clinical measures using @entity906 extended release or applied relaxation, and secondarily, the impact of combination treatment in @entity1 not remitting after 8  weeks. Fifty-eight @entity1 were randomly assigned to 8  weeks of treatment with either @entity906 or applied relaxation (Phase I). Non-remitted @entity1 received combination treatment for an additional 8  weeks (Phase II). Assessments included the Hamilton Anxiety Scale (HAM-A), Beck @entity308 Inventory, Penn State Worry Questionnaire and the Stroop Color-Word Task coupled with electrophysiological measures (skin conductance and frontalis electromyography (EMG)). In Phase 1, a time effect was found for the clinical and skin conductance measures. Thirteen @entity1 from each group were in remission. In Phase 2, seven additional @entity1 remitted. Baseline psychophysiological measures were not associated with baseline clinical variables or with clinical outcomes. Independently of treatment allocation, a reduction in frontal EMG values at week 4 was significantly associated with a decrease in HAM-A scores at week 8. At week 4, responders from the applied relaxation group had lower electrophysiological activity than the @entity906 group. Baseline psychophysiological measures were not linked with clinical measures at study inclusion or with treatment response. Frontal EMG response at week 4 is a possible predictor of treatment response. Treatment combination enhances treatment response after initial failure.
