Hormonal responses upon return of spontaneous circulation after XXXX : a retrospective cohort study.

@entity1 @entity4545 @entity66 @entity1887 @entity701 @entity1167 @entity6085 @entity130
INTRODUCTION: @entity1167 is often fatal and can be extremely stressful to @entity1 , even if spontaneous rhythm is returned. The purpose of this study was to analyze the hormonal response after return of spontaneous circulation (ROSC). METHODS: This is a retrospective review of the chart and laboratory findings in a single medical facility. The @entity1 admitted to the intensive care unit after successful resuscitation after out-of-hospital @entity1167 were retrospectively identified and evaluated. @entity1 with @entity66 , @entity1 who received @entity701 treatment, those experiencing @entity130 , and pregnant @entity1 were excluded. Serum @entity701 , @entity4545 (ACTH), and anti-diuretic hormone ( @entity6085 (vasopressin)) were analyzed and a corticotropin-stimulation test was performed. Mortality at one week and one month after admission, and neurologic outcome (cerebral performance category (CPC)) one month after admission were evaluated. RESULTS: A total of 117 @entity1 , including 84 males (71.8%), were evaluated in this study. One week and one month after admission, 87 (74.4%) and 65 @entity1 (55.6%) survived, respectively. Relative @entity1887 , and higher plasma ACTH and @entity6085 levels were associated with shock-related mortality (P = 0.046, 0.005, and 0.037, respectively), and ACTH and @entity6085 levels were also associated with late mortality (P = 0.002 and 0.004, respectively). @entity1 with relative @entity1887 , ACTH    5 pg/mL, and @entity6085    30 pg/mL, had a two-fold increased risk of a poor outcome (shock-related mortality): (odds ratio (OR), 2.601 and 95% confidence interval (CI), 1.015 to 6.664; OR, 2.759 and 95% CI, 1.060 to 7.185; OR, 2.576 and 95% CI, 1.051 to 6.313, respectively). Thirty-five @entity1 (29.9%) had a good CPC (1 to 2), and 82 @entity1 (70.1%) had a bad CPC (3 to 5). Age    50 years and an @entity6085    30 pg/mL were associated with a bad CPC (OR, 4.564 and 95% CI, 1.794 to 11.612; OR, 6.568 and 95% CI, 1.918 to 22.483, respectively). CONCLUSIONS: The @entity1 with relative @entity1887 and higher blood levels of ACTH and @entity6085 upon ROSC after @entity1167 had a poor outcome. The effectiveness of administration of @entity701 and @entity6085 to @entity1 upon ROSC after @entity1167 is uncertain and additional studies are needed.
