Activation of @entity13720 /STAT pathway in cerebral cortex after experimental traumatic brain injury of XXXX .

@entity131 @entity22943 @entity998 @entity12001 @entity3733 @entity30235 @entity13720 @entity35
The janus kinase/signal transducer and activator of transcription (JAK/STAT) is one of the main pathways downstream of cytokine receptors and growth factor receptors by transducing signals from cell surface to the nucleus. In this study, we aimed to survey the role of @entity13720 /STAT pathway in the progress of @entity131 . Right parietal cortical contusion in @entity35 was induced by the Feeney free @entity998 model. The activation of @entity13720 , @entity30235 and @entity12001 in pericontusional cortex was determined by Western blotting, electrophoretic mobility shift assay (EMSA), immunohistochemistry and immunofluorescence. Moreover, we assessed the neurological recovery (using Neurological Severity Scores (NSS)) of @entity35 under the pretreatment of a @entity13720 inhibitor, @entity22943 . Western blotting revealed that expression of p- @entity13720 , p- @entity30235 and p- @entity12001 increased immediately, peaked at 3h after @entity131 and decreased thereafter, and the activation could be inhibited by @entity22943 . Immunohistochemical study showed that @entity13720 /STAT pathway was activated in both neurons and astrocytes at 3h after @entity131 . @entity12001 -specific binding activity was obviously enhanced after @entity131 and down-regulated after @entity22943 administration. The higher NSS of @entity131 + @entity22943 group revealed a worse behavior recovery when compared with @entity131 + @entity3733 group. Our results suggest that the @entity13720 /STAT pathway is activated in pericontusional cortex of @entity35 , and may be involved in the neurological function recovery after @entity131 .
