Treatment of Platelet Products with XXXX and UV Light: Effectiveness Against High Titer Bacterial Contamination.

@entity5134 @entity796 @entity5938 @entity6419 @entity794 @entity4195 @entity3274 @entity5259 @entity8728 @entity526 @entity2820
Contamination of platelet units by bacteria has long been acknowledged as a significant transfusion risk due to their post-donation storage conditions. Products are routinely stored at 22   C on an agitating shaker, a condition that can promote bacterial growth. Although the total number of bacteria believed to be introduced into a platelet product is extremely low, these bacteria can multiply to a very high titer prior to transfusion, potentially resulting in serious adverse events. The aim of this study was to evaluate a @entity8728 based pathogen reduction process against a panel of bacteria that have been identified as common contaminants of platelet products. This panel included the following organisms: @entity5938 , @entity794 , @entity6419 , @entity4195 , @entity5134 , @entity2820 , B. neotomae, @entity5259 , E. coli, @entity796 and @entity3274 . Each platelet unit was inoculated with a high bacterial load and samples were removed both before and after treatment. A colony forming assay, using an end point dilution scheme, was used to determine the pre-treatment and post-treatment bacterial titers. Log reduction was calculated by subtracting the post-treatment titer from the pre-treatment titer. The following log reductions were observed: @entity5938 4.7 log (99.998%), @entity794 4.8 log (99.998%), @entity6419 3.7 log (99.98%), @entity4195 2.6 log (99.7%), @entity5134 4.0 log (99.99%), @entity2820 3.3 log (99.95%), B. neotomae 5.4 log (99.9996%), @entity5259 2.6 log (99.7%), @entity526 >= 5.4 log (99.9996%), @entity796 4.7 log (99.998%) and @entity3274 2.8 log (99.8%). The results from this study suggest the process could help to lower the risk of severe adverse transfusion events associated with bacterial contamination.
