Competitive displacement of mutans streptococci and inhibition of tooth decay by XXXX TOVE-R.

@entity1 @entity6586 @entity969 @entity281 @entity35 @entity20842
The ability of @entity20842 TOVE-R to displace virulent representatives of the most prevalent @entity1 mutans streptococci from the teeth of @entity35 , and thereby to inhibit caries, was studied. @entity6586 10449S- or @entity6586 sobrinus 6715-13WT-infected specific-pathogen-free @entity35 consuming a high- @entity969 diet were inoculated by TOVE-R. The infectants were differentially recovered from swabs of the teeth over the time course of @entity281 and from sonically treated material of extracted teeth and excised tongues. Despite initial colonization of the teeth by the mutans streptococci, TOVE-R colonized the teeth, unlike other essentially nonvirulent plaque formers already described. It did not colonize the tongues of the @entity35 . TOVE-R emerged and persisted as a prominent member of the plaque ecology. There was an associated decline in the mutans streptococci on the teeth, and this decline was associated with significant inhibition of the caries component attributable to 10449S @entity281 (56%) and to 6715-13WT @entity281 (52%). TOVE-R did not reliably inhibit the component of fissure caries attributable to the nonmutans indigenous flora of the @entity35 . TOVE-R itself induced no detectable decay. The data suggest the potential therapeutic utility of TOVE-R to inhibit caries by displacement of mutans streptococci from the teeth. These results supplement the already reported ability of TOVE-R to preempt initial colonization of teeth by the mutans streptococci.
