A longer duration of neo-adjuvant combined @entity342 blockade prior to radical prostatectomy may lead to lower XXXX volume of @entity263 .

@entity1 @entity14137 @entity263 @entity5 @entity342
OBJECTIVES: To analyse @entity5 volume (TV) in clinically @entity263 @entity1 treated with neo-adjuvant combined @entity342 blockade ( @entity14137 ) therapy prior to radical prostatectomy. @entity1 AND METHODS: Two hundred consecutive @entity1 treated between 1996 and 2000 were retrospectively analysed. Fifty @entity1 underwent radical prostatectomy alone and 45 were treated with @entity14137 for 1-3 months, 83 for 4-6 months and 22 for more than 6 months before surgery. Logistic regression analysis was performed to identify the strongest independent prognosticator of organ-confined disease. RESULTS: No evidence of @entity5 was found in 11 specimens (5.6%). Regarding TV, 20 specimens showed less than 0.1cc, 33 between 0.1 and 0.49cc and 86 more than 0.5cc. Smaller TV was found in @entity14137 -treated @entity1 . Significant correlation was observed between treatment duration and TV. In logistic regression analysis, only @entity14137 duration and TV were significantly correlated with organ-confined disease. CONCLUSIONS: Prominent regressive features and lower TV were found after neo-adjuvant @entity14137 . It seems that more prolonged treatment may lead to greater tumoural regression. Only @entity5 burden and length of @entity14137 therapy were independent variables significantly correlated with pathologically @entity263 .
