Expression of transforming growth factor-alpha, epidermal growth factor and the @entity470 in @entity263 and XXXX .

@entity1 @entity263 @entity1885 @entity470 @entity1067 @entity5072 @entity7790 @entity420
The present immunohistochemical study examines the expression of @entity7790 , EGF, and the @entity470 in prostatic tissues obtained from @entity1 with either @entity1067 ( @entity1067 ) or @entity263 . Frozen sections were cut at 5 microns and were incubated with monoclonal antibodies directed against @entity7790 , EGF, or the @entity470 . The remainder of the staining procedure was performed with an avidin- @entity1885 -complex peroxidase procedure. Strong @entity7790 expression was not detected in any of the 15 @entity1067 specimens examined or in the normal/ @entity5072 tissue intermixed within the @entity420 . In contrast, malignant cells in 9 of 11 @entity420 strongly expressed @entity7790 . EGF reactivity was observed in both @entity5072 and malignant epithelial tissues. @entity470 expression was strongest along the basal aspects of cells of normal or @entity5072 glands. Although most malignant cells also were positive for the @entity470 the level of staining was less than that observed in cells forming normal or @entity5072 glands. These results suggest that EGF and the @entity470 may be components of an autocrine/paracrine regulatory pathway involved in @entity5072 and/or malignant disease of the prostate. The finding that @entity7790 is expressed only in malignant cells suggests that @entity7790 may represent a locally active autocrine regulator of malignant prostate cells.
