The application of a collagen stabilizer to the gingiva of the @entity235 . Effect on ligature-induced XXXX .

@entity1 @entity2520 @entity235 @entity2521 @entity10273 @entity5951
The objective of this study was to determine the effect of crevicular application of a collagen stabilizer on ligature-induced @entity2520 in @entity235 . Fourteen male and female @entity235 , 15 months of age, were studied. The mandibular first molars and third and fourth premolars were ligated for 6 months and moderate @entity2521 resulted. Ligatures were removed for 2 months and then replaced for an additional 3 months to experimentally mimic the episodic changes seen in @entity1 @entity2520 . Following this phase, ligatures were removed and the animals were assigned to a placebo or treatment group. Medications were then applied intracrevicularly, three times a week over 5 months using an IMAX irrigator. Clinical indices measured were plaque index (PI), gingival index (GI), gingival crevicular fluid flow (GCF), @entity10273 ( @entity10273 ), @entity5951 ( @entity5951 ) and standardized radiographic analysis of alveolar bone height. While overall changes in PI, GI and GCF were not significant, the results showed that alveolar bone regeneration was increased approximately twice as much in the treatment group as compared to the placebo group, @entity5951 improved by 20% vs. 12.5% (P less than 0.001) and @entity10273 improved by 8.8% vs. 4.5% (P less than 0.001). The data were also evaluated in terms of the response in more severe sites as compared to those less severe. The results of these evaluations showed the more severe sites to be significantly more responsive to treatment than the less severe sites.(ABSTRACT TRUNCATED AT 250 WORDS)
