Topical applications of XXXX on implant surface for bone-to-implant contact enhance: a pilot study in @entity235 part II.

@entity235 @entity6684 @entity604 @entity702 @entity560
OBJECTIVE: The aim of this study was to evaluate the effect of topical application of @entity560 over implant surface, placed immediately to the extraction, throughout histological and histomorphometric analysis of peri-implant tissue. MATERIAL AND METHODS: Six American foxhound @entity235 were used in the study. Mandibular premolar distal roots were extracted. Twenty-four immediate conical C1 implants (MIS, Barlev, Israel) were randomly assigned to the distal site on each site of the mandible in three groups: (Group CI) 12 @entity702 implants alone; (Test Group @entity6684 ) 12 @entity702 implants supplemented with @entity560 . Prior to implanting, test implants ( @entity6684 ) were submerged in @entity560 10% solution. No treatment was applied at control implants (CI). After 12  weeks, animals were sacrificed. Block sections were obtained and processed for mineralized ground sectioning. Bone-to-implant contact (Total BIC and BIC%), new bone formation (NBF), interthread bone (ITB), and histological linear measurements (HLM) were analyzed. RESULTS: At 12  weeks, all implants were clinically stable and histologically osseointegrated. BIC evaluation showed Total BIC mean and SD values for @entity6684 (48.96      2.14), CI (44.56      1.75) (P  <  0.05), BIC% @entity6684 (43.59      0.98), and CI (42.67      9.26) (P  >  0.05). For interthread bone formation, values were as follows: @entity6684 (15.21      3.87), CI (14.79      1.45) (P  >  0.05), no statistically differences. Regarding peri-implant new bone formation, no statistically differences could be found between the two groups @entity6684 (31.87      1.23), CI (27.18      2.38) (P  >  0.05). For linear measurements, test group ( @entity6684 ) showed statistically significant less @entity604 (CBL) @entity6684 (0.37      0.12)*, CI (1.26      0.8) (P  <  0.05), and @entity560 implants showed less lingual junctional epithelium @entity6684 (1.58      0.43)*, CI (2.18      0.48) (P  <  0.05). No differences were observed in the buccal mucosa. CONCLUSION: With the limitation of animal studies, topical application of @entity560 on dental implants could reduce crestal @entity604 and increase 10% more bone-to-implant contact at 12-week follow-up period.
