The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of @entity17014 and @entity72446 of XXXX Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on @entity284 Therapy.

@entity1 @entity72446 @entity17014 @entity6253 @entity158 @entity284 @entity40000 @entity39999
INTRODUCTION: We recently reported that a majority of opioid-dependent Malay males on @entity284 therapy are @entity158 sensitive. It is postulated that common @entity6253 polymorphisms may be responsible. This study investigated the association between @entity17014 (dbSNP @entity39999 ) and @entity72446 (dbSNP @entity40000 ) variants on @entity158 responses among opioid-dependent Malay males on @entity284 maintenance therapy. METHODS: @entity158 responses including @entity158 threshold, @entity158 tolerance, and @entity158 intensity were measured using the cold pressor test. DNA was extracted from the venous blood before polymerase chain reaction genotyping. Repeated measures analysis of variance was used to compare the @entity158 responses and @entity6253 polymorphisms ( @entity17014 and @entity72446 ) using models including genotype dominant and recessive models, allelic additive models, and analysis of haplotypes and diplotypes. RESULTS: A total of 148 @entity1 were recruited. With the recessive model, those with IVS2+691 homozygous CC genotype had a shorter @entity158 tolerance time than those without CC genotype (i.e., GG/GC genotype; 29.81 vs. 43.08  s, respectively, P  =  0.048). On the other hand, with diplotype analysis, @entity1 with combined homozygous 118 AA genotype and heterozygous IVS2+691 GC genotype (i.e., AC/AG diplotype) had a longer @entity158 tolerance time than those without this diplotype (49.34 vs. 31.48  s, respectively, P  =  0.043). @entity158 threshold was not associated with any of the @entity17014 and @entity72446 variations despite being analyzed using various models (all P  >  0.05). CONCLUSION: The IVS2+691 CC genotype and AC/AG diplotype of @entity17014 and @entity72446 seem to have opposing roles in @entity158 tolerance among opioid-dependent Malay males on @entity284 therapy. Haplotypes of @entity6253 may be associated with altered binding affinity.
