Human leukocyte antigen-G is closely associated with XXXX immune escape in @entity356 by increasing local regulatory T cells.

@entity1 @entity650 @entity39 @entity5 @entity6393 @entity688 @entity356
Human leukocyte antigen-G ( @entity6393 ) plays an important role in @entity5 cell escape. We investigated @entity6393 expression and regulatory T cells (Tregs) infiltrates in @entity1 with @entity356 ( @entity356 ), analyzed their relationship with clinicopathologic features, and characterized their role in @entity5 immune escape. We also investigated the plasma soluble @entity6393 level and its potential in the diagnosis of @entity356 . Effect of @entity6393 on Tregs was further assessed by coculture experiments in vitro. Most interestingly, @entity6393 positive expression was detected in @entity356 tissues and it was significantly correlated with the presence of @entity5 -infiltrating Tregs. @entity1 with @entity6393 positive expression or high Tregs had significantly poorer survival at 5 years after operation. Multivariate analysis indicated that @entity6393 positive expression was an independent prognostic factor of @entity356 . The coculture experiment showed overexpression of @entity6393 in @entity356 cell lines significantly enhanced the frequency of Tregs when @entity356 cells were directly cocultured with @entity1 peripheral blood mononuclear cell. However, this effect disappeared when the indirect coculture system was applied. Some cytokines such as @entity650 , @entity688 , and @entity5 @entity39 factor-a significantly changed in the coculture system. Moreover, plasma soluble @entity6393 level in @entity356 @entity1 was higher than that in normal controls. Taken together, our results indicated that @entity6393 expression was closely associated with @entity5 progression and involved in @entity5 evasion by increasing the frequency of infiltrating Tregs locally. Thus, @entity6393 might be a promising predictor for disease prognosis and a possible novel target for immunotherapy in @entity356 @entity1 .
