The Attenuation of Pain Behavior and Serum XXXX Concentration by @entity6108 in a @entity35 Model of @entity9 .

@entity1931 @entity406 @entity128 @entity6108 @entity158 @entity35 @entity4665 @entity8638 @entity1118 @entity9
BACKGROUND: @entity9 is generally defined as a @entity1118 state resulting from peripheral and/or central @entity128 . There is a lack of effective treatment for @entity9 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity6108 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity1118 induced by peripheral administration of inflammatory agents such as @entity406 . In this study, we aimed to show the effect of @entity6108 on @entity158 behavior and serum @entity4665 level in a @entity8638 ( @entity8638 ) model of @entity9 . METHODS: @entity35 male @entity35 (150-200 g, n = 8) were divided into three groups: @entity8638 vehicle-treated, sham-operated, and @entity8638 drug-treated group. @entity6108 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity4665 level was measured on day 7 after the surgery. RESULTS: @entity6108 (50 mg/kg) decreased mechanical and cold @entity1931 (P < 0.001) and produced a decline in serum @entity4665 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity158 behavior and serum @entity4665 levels was seen in @entity35 following administration of @entity6108 in @entity8638 model of @entity9 . High concentration of @entity6108 was able to reduce the chronic @entity9 induced by @entity8638 model and the serum level of @entity4665 .
