Overweight and XXXX as determinants of cardiovascular risk: the Framingham experience.

@entity1 @entity455 @entity64 @entity1007 @entity101 @entity6 @entity301 @entity28 @entity951 @entity583 @entity65
BACKGROUND: To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for @entity101 , @entity1007 , @entity6 , and @entity65 has been reported. METHODS: Relations between categories of body mass index (BMI), @entity65 risk factors, and @entity455 end points were examined prospectively in Framingham Heart Study @entity1 aged 35 to 75 years, who were followed up to 44 years. The primary outcome was new @entity65 , which included @entity951 , @entity583 , @entity301 , or @entity64 . Analyses compared overweight (BMI [calculated as weight in kilograms divided by the square of height in meters], 25.0-29.9) and @entity28 @entity1 (BMI > or =30) to a referent group of normal-weight @entity1 (BMI, 18.5-24.9). RESULTS: The age-adjusted relative risk (RR) for new @entity101 was highly associated with overweight status ( @entity1 : RR, 1.46; @entity1 : RR, 1.75). New @entity1007 and @entity6 were less highly associated with excess adiposity. The age-adjusted RR (confidence interval [CI]) for @entity65 was increased among those who were overweight ( @entity1 : 1.21 [1.05-1.40]; @entity1 : 1.20 [1.03-1.41]) and the @entity28 ( @entity1 : 1.46 [1.20-1.77]; @entity1 : 1.64 [1.37-1.98]). High population attributable risks were related to excess weight (BMI > or =25) for the outcomes @entity101 (26% @entity1 ; 28% @entity1 ), @entity951 (26% @entity1 ; 22% @entity1 ), and @entity301 (23% @entity1 ; 15% @entity1 ). CONCLUSIONS: The overweight category is associated with increased relative and population attributable risk for @entity101 and @entity65 . Interventions to reduce adiposity and avoid excess weight may have large effects on the development of risk factors and @entity65 at an individual and population level.
