Expression of XXXX and C-type lectin receptors in Behcet's disease.

@entity1 @entity1530 @entity66 @entity1333 @entity16435 @entity3998 @entity2940 @entity9706 @entity4071 @entity195 @entity43613
OBJECTIVE: @entity195 ( @entity195 ) is a @entity66 with a possible underlying pathology of immune-mediated @entity1333 . Genetic susceptibility associated with @entity1530 *51 and B*2702 has been implicated in its pathogenesis. Considering the recently defined regulatory mechanisms of NK cells through HLA class I binding receptors, we hypothesized that interactions of NK and T cells through the NK receptors may be important in the pathogenesis of @entity195 . METHODS: The impact of different expression patterns of HLA-recognizing receptors on NK or T cells was analysed in 51 @entity1 with @entity195 and 32 healthy controls. We used flow cytometry to investigate the expression of @entity16435 from the polymorphic killer immunoglobulin-like receptor ( @entity16435 ) family, which binds a shared HLA-Bw4 motif on HLA-B51 and *2702 alleles, and @entity9706 from the conserved C-type lectin receptor family, which binds @entity3998 . Thirty-three of the @entity195 @entity1 and 19 of the controls carried the same HLA-Bw4 motif. RESULTS: CD3(+) T cells were increased in @entity1 with @entity195 compared with controls (81 vs 75%, P = 0.001), whereas the NK cells did not show any difference between the two groups. Increased expression of @entity9706 in @entity195 was observed on @entity4071 (+) @entity2940 (+) cells (66 vs 57, P = 0.04) and on CD3(+) (7.7 vs 4.0, P < 0.001) and CD3(+) @entity2940 (+) (44 vs 35, P = 0.02) T cells. @entity16435 expression on the NK and T cells was not statistically different between the two groups. No effect of @entity43613 motif was observed on the expression of @entity9706 and @entity16435 in both the @entity1 and the controls. CONCLUSION: The absence of a correlation between @entity16435 expression and HLA-Bw4 motif confirms previous work reporting that the expression of these molecules is regulated separately. Increased expression of @entity9706 may suggest that NK receptors play a pathogenic or regulatory role in @entity195 .
