Segmental Analysis of Macular Layers in XXXX With Unilateral Primary Open-Angle Glaucoma.

@entity1 @entity725 @entity227 @entity735 @entity1358
PURPOSE: To measure the thicknesses of the inner layers of the macula in both eyes of @entity1 with unilateral @entity725 ( @entity725 ) and compare them with normal control eyes. METHODS: This prospective, cross-sectional pilot study enrolled @entity1 with unilateral @entity725 , who had @entity227 in only 1 eye, and controls with a normal eye examination. Horizontal and vertical B-scan images centered on the fovea were obtained using spectral domain optical coherence. Semiautomatic delineation and segmentation of the inner layers of the retina were performed to evaluate macular retinal nerve fiber layer (mRNFL), @entity1358 (GC-IPL) thicknesses. Mean, superior, inferior, nasal, and temporal inner macular layer thicknesses were compared between affected eyes, @entity735 without @entity227 , and control eyes. RESULTS: Nineteen @entity1 with unilateral @entity725 and 14 normal control eyes were enrolled. In the affected @entity725 eyes, thinning of the mRNFL, GCC, and GC-IPL layers on horizontal and vertical scans were significant when compared with controls (P<0.05), particularly on vertical scans (P<0.001). The mean regional macular GCC and GC-IPL were most severely thinned in the inferior and temporal perifoveal regions. The unaffected eye of @entity1 with unilateral @entity725 showed significant thinning of the mRNFL only in the vertical scan when compared with normal controls (P<0.05). CONCLUSIONS: Spectral domain optical coherence tomography detected significant thinning of the mRNFL, GCC, and GC-IPL in the affected eyes of @entity1 with unilateral @entity725 . @entity735 showed early structural changes only in the vertical mRNFL scans when compared with normal controls.
