Decreased isokinetic trunk muscle strength and performance in long-term survivors of childhood XXXX : correlation with hormonal defects.

@entity1 @entity251 @entity5 @entity16 @entity2124 @entity348 @entity3257
OBJECTIVE: To evaluate trunk muscle strength and performance in long-term survivors of childhood @entity5 relative to age and sex-matched controls, and to relate the muscle strength observations to the therapeutic agents used and possible hormonal disturbances. DESIGN: Age and sex-matched cohort study. SETTING: Referral center in the northern part of Finland. @entity1 : Forty-six long-term survivors of childhood @entity5 . Mean age at examination 19.1 years and median off-therapy time 9.4 years. INTERVENTION: Isokinetic dynamometer testing. MAIN OUTCOME MEASURES: Measurements of trunk muscle peak torque (PT) and @entity348 ( @entity348 ) were performed at angle speeds of 50 degrees/sec and 200 degrees/sec. The results were normalized relative to body fat-free weight (FFW). RESULTS: PT in the trunk muscles was lower in the @entity1 at both angle speeds (mean normalized PT = 5.7Nm/kgFFW vs 7.6Nm/kgFFW for controls at 50 degrees/sec), as also was @entity348 except for extension @entity348 at the higher angle speed (mean normalized @entity348 = 59.9J/kgFFW vs 84.6J/kgFFW for controls at 200 degrees/sec). The normalized PT at 50 degrees/sec and @entity348 at 200 degrees/sec were lower in the males with @entity16 ; also, low age at diagnosis correlated positively with muscle strength and performance. There were no differences in normalized PTs or TWDs between cranial radiation and non-radiation cases, or between @entity2124 -deficient and @entity3257 cases, and the @entity1 without cranial radiation or with normal growth hormone secretion still had lower normalized PTs and TWDs than the controls. CONCLUSIONS: Survivors of childhood @entity5 have decreased maximal trunk muscle strength and performance. The etiology of this effect remains unclear, but young age at diagnosis, as well as serum @entity251 levels in male survivors, evidently influence muscle strength and performance.
