The induction of abortion with XXXX .

@entity1 @entity691 @entity6003 @entity390 @entity1421 @entity294 @entity391 @entity2918 @entity221
Successful use of @entity2918 (PGs) for pregnancy termination was first reported by Karim and Filshie in 1970 following successful induction of abortion in 26 out of 27 @entity1 within less than 18 hours of continuous infusion of 50 mcg/minute PGF2alpha or 5 mcg/minute @entity1421 . Subsequent clinical trials of @entity1421 and PGF2alpha using the continuous infusion method also reported satisfactory success rates. The intravenous route at therapeutically effective doses is associated with side effects such as @entity390 , @entity391 , @entity294 , @entity221 and a local erythematous reaction at the site of venipuncture. These side effects may be minimized by using other routes of administration, such as the intrauterine route which requires considerably smaller total dosage compared to the intravenous route. The intrauterine route involves introducing the PGs via a thin @entity691 catheter between the fetal membranes and the uterine wall. The vaginal route is also used in abortion. In the only study reported so far, repeated vaginal administration of either 50 mg PGF2alpha or 20 mg @entity1421 into the vaginal fornix every 2 1/2 hours resulted in abortion in all 45 @entity1 (Karim 1971). There were no side effects, abortion-interval was shorter compared to the intravenous route, and the drug was easy to administer. The intraamniotic route can terminate pregnancy with a single dose (either 25 mg PGF2alpha or 5 mg @entity1421 ) or with 2 doses in some cases. The procedure of introducing PGs into the amniotic cavity is simple and does not require prior withdrawal of amniotic fluid as in cases of saline induced abortion. @entity390 and @entity391 occasionally occur in some @entity1 , but the procedure is relatively free from side effects. This method is suitable only in pregnancies of over 12 weeks' duration because of the inaccessibility of the amniotic sac before this period. PG use in early pregnancy termination is not highly recommended because of the medical personnel time required and the higher incidence of @entity6003 . In 2nd trimester abortions, PGs offer clear advantages over other methods.
