@entity27 on serum aminotransferase levels in @entity28 XXXX .

@entity1 @entity1560 @entity28 @entity167 @entity27 @entity412 @entity492 @entity493 @entity792 @entity413
PURPOSE: Obesity has been associated with @entity27 and @entity1560 . We investigated the effects of @entity27 and treatment with nasal continuous positive airway pressure (CPAP) on serum aminotransferase levels in @entity28 @entity1 . METHODS: We studied 40 @entity28 @entity1 with @entity27 . None had hepatitis B antigen or C antibody, @entity792 , or an excessive intake of @entity167 . Serum levels of @entity492 aminotransferase, @entity493 aminotransferase, @entity412 , @entity413 , insulin, and leptin were determined in the afternoon and in the morning immediately after sleep, before and after nasal CPAP treatment. RESULTS: Aminotransferase levels were abnormal in 35% (n = 14) of @entity1 . Before treatment, mean (+/- SD) @entity492 aminotransferase levels were higher in the morning than in the previous afternoon (presleep, 34 +/- 20 IU/L; postsleep, 39 +/- 28 IU/L; P = 0.006). The overnight mean increases in aminotransferase levels were less marked after the first night of nasal CPAP treatment ( @entity492 aminotransferase: from 6 +/- 11 IU/L to 2 +/- 6 IU/L, P = 0.0003; @entity493 aminotransferase: from 5 +/- 9 IU/L to 2 +/- 6 IU/L, P = 0.006). Leptin levels (n = 23) decreased significantly after treatment (P = 0.0002), whereas insulin resistance (calculated by the homeostasis model assessment method) and @entity412 levels were unchanged. Improvements in @entity492 and @entity493 aminotransferase levels were maintained after 1 and 6 months of nasal CPAP treatment. CONCLUSION: Nasal CPAP therapy may have beneficial effects on serum aminotransferase abnormalities in @entity28 @entity1 who @entity27 .
