Patterns and predictors of recurrence after radical resection of XXXX .

@entity1 @entity5 @entity704
BACKGROUND: Recurrence of @entity704 even after complete resection is common, but the relapse patterns remain controversial. This study aimed to define the patterns and predictors of relapse after complete resection of @entity704 . METHODS: A single-institution retrospective study was performed with 331 @entity1 who underwent radical resection of @entity704 between 1991 and 2012. RESULTS: After a median follow-up of 59months, the recurrence rate was 6.9% (23/331). Relapse occurred in 23 @entity1 with the pleura (14) and @entity5 bed (6) as the most common sites of recurrence. According to the definitions of the International Thymic Malignancy Interest Group, 10 (43.5%) @entity1 had local relapse, 15 (65.2%) had regional relapse, 10 (43.5%) had distant relapse. The difference in survival following relapse between lung and regional relapse was statistically significant (P=0.027) but that between lung and distant relapse was not (P=0.808). The recurrence rates correlated with the initial Masaoka stage. Further, recurrence also correlated with World Health Organization (WHO) @entity5 type. The recurrence-free survival rates in @entity1 with @entity5 size    8cm were worse than those of @entity1 with @entity5 size <8cm (P=0.007). @entity5 size was also correlated with stage (r=0.110). As @entity5 becomes larger, the stage is more advanced (P=0.023). Multivariate analysis showed that Masaoka stage (P=0.005), @entity5 size (P=0.033), and WHO histological type (P=0.046) were predictive factors of relapse. CONCLUSION: Regional recurrence is the most common relapse pattern but local and distant relapse are also common. Advanced Masaoka stage, larger @entity5 size, and type B3 are risk factors of recurrence. Lung relapse should be considered distant relapse. Further, @entity5 size was correlated with Masaoka stage and therefore should be considered in the staging system.
