XXXX reduces asymptomatic embolization after carotid angioplasty.

@entity1 @entity64 @entity12557 @entity117 @entity887 @entity661 @entity12558 @entity842 @entity543
BACKGROUND: The major complication of carotid angioplasty is @entity64 , which may occur @entity661 or in the early postintervention period. Platelet adhesion and aggregation to the angioplasty site with subsequent embolization seems to plays a major role in early postangioplasty embolization and @entity64 . During this period, asymptomatic @entity887 can be detected in @entity1 by transcranial Doppler ultrasound despite aspirin and heparin treatment. @entity12557 ( @entity12558 ) is a @entity842 donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization after carotid angioplasty. METHODS AND RESULTS: Sixteen @entity1 undergoing carotid angioplasty and stenting for symptomatic > or =70% internal @entity543 were randomized in a double-blind manner to @entity12558 or placebo given after surgery for 90 minutes. All @entity1 were pretreated with @entity117 and given heparin for 24 hours after the procedure. Transcranial Doppler recordings were made from the ipsilateral middle cerebral artery for 1 hour before treatment and at 0 to 3, 6, and 24 hours after treatment. @entity12558 resulted in a rapid reduction in the frequency of @entity887 of 95% at 0 to 3 hours and 100% at 6 hours (P=0.007 and P=0.01 versus placebo, respectively). In the placebo group, 2 @entity1 experienced @entity64 after the angioplasty. No cerebrovascular events occurred in the @entity12558 group. CONCLUSIONS: @entity12557 was highly effective in rapidly reducing the frequency of @entity887 after endovascular treatment for symptomatic high-grade @entity543 .
