Effects of exercise training on the XXXX antioxidant system.

@entity2197 @entity9492 @entity2041 @entity1503
PURPOSE: The @entity2041 ( @entity2197 ) antioxidant system has been shown to play an important role in the maintenance of good health and disease prevention. Various approaches have been used to enhance @entity2197 availability including diet, nutritional supplementation, and drug administration, with minor to moderate success. Exercise training has evolved as a new approach. The purpose of this study was to investigate the effects of aerobic exercise training (AET), circuit weight training (CWT), and combined training (AET+CWT) on general adaptations, and resistance to acutely induced oxidative stress, as assessed by changes in the @entity2197 antioxidant system. METHODS: Eighty healthy sedentary volunteers participated in the study who were randomly assigned to four groups: control (no exercise); AET, CWT, and AET+CWT. Exercise training programs were designed to simulate outpatient cardiac rehabilitation (40 min x 3 days x 6 weeks). @entity1503 sampling was taken at rest and post maximal graded exercise test (GXT). A new improved spectrophotometric venous assay analysis technique was used. A mixed model repeated measures analysis of variance design was used with t-tests for preplanned comparisons evaluated at Bonferroni-adjusted alpha levels. RESULTS: Effectiveness of the exercise training programs was demonstrated by significant between-group (exercise group versus control) comparisons. AET, CWT, and AET+CWT showed significant pretraining-posttraining increases in resting @entity2197 and @entity2041 - @entity9492 ratio ( @entity2197 : @entity9492 ), and significant decreases in @entity9492 levels (P<0.005). AET+CWT showed the most pronounced effect compared with AET or CWT alone (P<0.025). CONCLUSION: This study represents the first longitudinal investigation involving the effects of multiple modes of exercise training on the @entity2197 antioxidant system with evidence, suggesting the GHS: @entity9492 ratio as the most sensitive change marker. The significant findings of this study have potential clinical implications to individuals involved in cardiac and pulmonary rehabilitation.
