Oncologic and Functional Outcomes of Laparoendoscopic Single-Site Radical Nephrectomy for Localized XXXX : A Single Surgeon's Series with a Minimum of 3-Year Follow-Up.

@entity1 @entity8 @entity5 @entity740 @entity3 @entity703
OBJECTIVE: To evaluate intermediate-term oncologic and renal functional outcome of laparoendoscopic single-site radical nephrectomy (LESS-RN) in the treatment of localized @entity703 . METHODS: We performed a chart review of @entity1 who underwent LESS-RN between 2009 and 2011 at our institution. @entity1 with a minimum of 3 years of follow-up were included in this study. The demographic data and main perioperative outcome variables were analyzed. Estimated glomerular filtration rate was calculated using the Modification of Diet @entity8 equation. @entity740 ( @entity740 ) was calculated. The Kaplan-Meier method was used to calculate overall survival (OS), @entity5 -specific survival (CSS), and @entity5 ( @entity5 ). Multivariate logistic regression was performed to show predicting factors for an undesirable outcome arbitrarily defined as any one or more of the following events: surgical conversion, complication of Clavien grade >2, new onset of @entity740 stages >= 3 at the latest follow-up, or @entity5 recurrence or @entity3 . RESULTS: A total of 51 @entity1 were included with a median follow-up of 41 (interquartile range: 38-45) months. The OS, CSS, and @entity5 rates at 3 years were 100%, 100%, and 98%, respectively. There was a 74.5% (38/51) upstaging of @entity740 at the latest follow-up, with 22 @entity1 (43.1%) who developed a new onset of @entity740 stages >= 3. Multivariate analysis showed that @entity1 age, body mass index, Charlson comorbidity index, early surgeon experience, and follow-up duration (all p   <   0.05) have increased the odds of an undesirable outcome. CONCLUSIONS: For localized @entity703 , LESS-RN is effective in oncologic control at an intermediate follow-up interval but, similar to other kinds of RN technique, it is associated with worsened renal functional outcomes.
