XXXX excretion: a story that is easy to digest.

@entity1 @entity742 @entity3157 @entity2507 @entity972 @entity6085 @entity4144
The aim of this article is to consider how a large quantity of @entity972 (K+) can be excreted without the development of @entity4144 . The hypothesis will focus on interactions between K+ and @entity3157 - primarily within the kidneys. It is speculated that the absorption of K+ from the gastrointestinal tract is accompanied by an initial addition of @entity3157 - to the body; this in turn could, via intrarenal events, promote the delivery of @entity3157 - to the cortical collecting duct (CCD), where interactions may permit the development of a very high rate of excretion of K+. To test one portion of this hypothesis, studies were performed in @entity742 because they normally consume approximately 10-fold more K+ per kilogram body weight than do @entity1 . In the absence of a significant degree of anabolism, there is only a limited potential to shift K+ acutely into cells. Hence, an extremely large capacity to excrete K+ is required to avoid a severe degree of @entity4144 . The excretion of K+ depends primarily on the ability to have a sustained rise in the (K) in each liter of luminal fluid exiting the CCD to very high levels and to have a large number of liters of fluid exit the terminal CCD while antidiuretic hormone is acting. A reasonable approximation of this CCD flow rate can be obtained by examining the osmole excretion rate when @entity6085 acts. Because these @entity742 excreted 1,650 mosmol (2 L x 827 mosm/kg @entity2507 ) per day, a minimum estimate for volume delivery out of the CCD is 5 to 6 L/day.(ABSTRACT TRUNCATED AT 250 WORDS)
