XXXX -Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases.

@entity1 @entity39 @entity5 @entity146 @entity1822 @entity9653 @entity11090 @entity791 @entity2909
The number of reported cases of smooth @entity11090 (SMT) arising in @entity1 with @entity791 has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of @entity9653 -related SMT (EBV-SMT) in @entity1 with @entity791 . An English language literature search identified 53 articles including 64 reported cases of EBV-SMT. The majority of these reports involved @entity1 who were young, severely immunosuppressed, and had multifocal @entity5 . The central nervous system was the most common site to be involved. Histologically, @entity5 had smooth muscle features and were immunoreactive for muscle markers and all but two @entity5 demonstrated the presence of EBV by either immunohistochemistry, in situ hybridization, and/or PCR. While mitoses and/or @entity39 were used to separate @entity2909 from @entity1822 , these features did not correlate with clinical outcome. Treatment included primarily resection, and less often radiotherapy, chemotherapy and highly active antiretroviral therapy (HAART). Overall, EBV-SMTs appear to have variable @entity146 and clinical outcome and may exhibit a more favorable prognosis compared to @entity1822 . Tumor-related death from EBV-SMT occurred in only 4 of 51 @entity1 .
