Flavonoid effects relevant to XXXX .

@entity1 @entity0 @entity5 @entity584 @entity25449 @entity3818 @entity1460 @entity375
Flavonoids, such as daidzein and genistein, present in dietary plants like @entity1460 , have unique chemical properties with biological activity relevant to @entity5 . Many flavonoids and polyphenols, including resveratrol in red wine and epigallocatechin gallate in green tea, are known antioxidants. Some of these compounds have estrogenic (and antiestrogenic) activity and are commonly referred to as phytoestrogens. A @entity375 -based estrogen receptor (ER) reporter assay has been used to measure the ability of flavonoids to bind to ER and activate estrogen responsive genes. Recently, estrogenic compounds were also shown to trigger rapid, nongenomic effects. The molecular mechanisms, however, have not been completely detailed and little information exists regarding their relevance to @entity5 progression. As a preliminary step toward elucidating rapid phytoestrogen action on @entity0 cells, we investigated the effect of 17-beta estradiol (E2), genistein, daidzein and resveratrol on the activation status of signaling proteins that regulate cell survival and invasion, the cell properties underlying @entity0 progression. The effect of these estrogenic compounds on the activation, via phosphorylation, of @entity584 / @entity25449 ( @entity584 ) and @entity3818 ( @entity3818 ) were analyzed in ER-positive and -negative @entity1 @entity0 cell lines. E2, genistein and daidzein increased whereas resveratrol decreased both @entity584 and @entity3818 phosphorylation in nonmetastatic ER-positive T47D cells. In metastatic ER-negative MDA-MB-231 cells, all estrogenic compounds tested increased @entity584 and @entity3818 phosphorylation. The inhibitory action of resveratrol on cell survival and proliferation is ER dependent. Therefore, all estrogenic compounds tested, including resveratrol, may exert supplementary ER-independent nongenomic effects on cell survival and migration in @entity0 cells.
