Feasibility and accuracy of TRUS in the pre-treatment staging for XXXX in general practice.

@entity5 @entity1 @entity189
AIMS: Transrectal ultrasonography (TRUS) is the diagnostic tool of choice for local staging of @entity189 . The accuracy in determining of @entity5 infiltration depth has been reported to reach 95% (on average, 85%). The aim of the study was to analyse the diagnostic accuracy of the TRUS in the clinical routine. @entity1 AND METHODS: From 01/01/2000 to 12/31/2003, all @entity1 with @entity189 were enrolled in a prospective multicenter observational study. In case of complete findings of pre-operative TRUS and post-operative histological investigation of the surgical specimen on the @entity5 infiltration depth, overall accuracy of TRUS was determined. RESULTS: Overall, 13,610 @entity1 with @entity189 were enrolled in the study. Five thousand and fifty-six subjects (37%) underwent TRUS. In 3,501 @entity1 , TRUS finding (uT-stage) could be compared with the result of the definitive histologic investigation (pT-stage). The accuracy of TRUS in all T-stages was 65.8%. The highest sensitivity was achieved in the T3-stage (74.9%), while in T2, T1, and T4, it was 59.6, 59.0 and 31.1%, respectively. In discriminating @entity5 growth limited to the rectal wall vs that through the rectal wall into the neighboring tissue, TRUS-associated accuracy was 76.5%. There were no differences between various @entity5 locations above the anocutaneous line. CONCLUSIONS: Diagnostic accuracy of TRUS in determining depth of @entity5 infiltration within or through the rectum wall in the routinuous diagnostic of @entity189 does not reach the excellent published study results. A considerable improvement of the qualitative outcome in using this specific diagnostic tool appears to be recommendable to utilize its advantages such as high accuracy, efficacy, and practicability in the diagnostic process and deriving consequences for a possible neoadjuvant treatment as well as optimal planning of the surgical approach.
