@entity8385 and XXXX accelerate alveolar bone development.

@entity2447 @entity19 @entity79 @entity13421 @entity8385 @entity16843 @entity18435 @entity71720 @entity7739
@entity79 is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. @entity19 at embryonic (E) day 13.5 to @entity16843 ( @entity16843 ) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from @entity19 at PN7.5 were pretreated with @entity8385 , @entity7739 , @entity13421 , or BSA, and grafted subcutaneously into @entity19 . The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with @entity8385 and @entity7739 , but not with @entity13421 . Gene expression levels in dental follicle cells from @entity19 molars were also determined by real-time RT-PCR. The expression levels of @entity2447 , @entity71720 , and Ocn were significantly higher in dental follicle cells cultured with @entity8385 or @entity7739 , and significantly lower in those cultured with @entity13421 when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and @entity18435 appears to accelerate alveolar bone development.
