Repeated magnetic resonance imaging and cerebral performance after XXXX --a pilot study.

@entity1 @entity2806 @entity63 @entity158 @entity1167 @entity2332
AIM OF THE STUDY: Prognostication may be difficult in comatose @entity1167 survivors. Magnetic resonance imaging (MRI) is potentially useful in the prediction of neurological outcome, and it may detect acute @entity63 at an early stage. In a pilot setting we determined the prevalence and development of @entity2806 using serial MRI examinations and neurological assessment. METHODS: Ten witnessed out-of-hospital @entity1167 @entity1 were included. MRI was carried out approximately 2h after admission to the hospital, repeated after 24h of therapeutic @entity2332 and 96 h after the arrest. The images were assessed for development of @entity2806 . Neurophysiological and cognitive tests as well as a self-reported quality-of-life questionnaire, Short Form-36 (SF-36), were administered minimum 12 months after discharge. RESULTS: None of the @entity1 had @entity2806 on MRI at admission. Three @entity1 developed @entity2806 after therapeutic @entity2332 . There was a change in the apparent diffusion coefficient, which significantly correlated with the temperature (p < 0.001). The neurophysiological tests appeared normal. The @entity1 scored significantly better on SF 36 than the controls as regards both bodily @entity158 (p = 0.023) and mental health (p = 0.016). CONCLUSIONS: MRI performed in an early phase after @entity1167 has limitations, as MRI performed after 24 and 96 h revealed @entity2806 not detectable on admission. ADC was related to the core temperature, and not to the volume distributed intravenously. Follow-up neurophysiologic tests and self-reported quality of life were good.
