Prognostic significance of platelet-derived growth factor receptor-b expression in localized XXXX .

@entity1 @entity2558 @entity6006 @entity7 @entity5 @entity319 @entity1358 @entity3820 @entity1349
PURPOSE: We investigated the expression status of @entity7 ( @entity7 ), @entity6006 and their receptors in organ-confined @entity1358 ( @entity1358 ) to evaluate their prognostic significance after radical surgery. METHODS: In 758 consecutive @entity1 diagnosed with @entity2558 -2N0 @entity1358 between 2007 and 2012, we prospectively investigated the expression levels of @entity7 , @entity6006 , @entity319 ( @entity319 ) and @entity3820 ( @entity3820 )-b via immunohistochemistry. Clinicopathologic parameters and expression of the angiogenic factors were analyzed with respect to @entity1349 ( @entity1349 ) after nephrectomy. The median follow-up was 29.5  months (IQR 21.5, 39.6) after surgery. RESULTS: Partial nephrectomy had been performed in 48.5  % of the @entity1 , and @entity5 were staged as pT1a in 514 (67.8  %), pT1b in 192 (25.3  %) and pT2 in 52 (6.9  %). @entity7 , PDGF and their receptors were identified in the cytoplasm and membranes of the @entity5 cells. Expression level of @entity319 inversely correlated with both @entity5 size (r  =  -0.076, p  =  0.014) and nuclear grade (r  =  -0.297, p  =  0.004). As for @entity6006 , the expression level showed an inverse correlation with @entity5 size (r  =  -0.216, p  <  0.001) while @entity3820 -b inversely correlated with nuclear grade (r  =  -0.341, p  =  0.001). On multivariate analysis, age, pathologic stage, nuclear grade and @entity3820 -b expression (high vs. low or none, HR 3.121 95  % CI 1.300-7.493, p  =  0.011) were independently prognostic of @entity1349 after nephrectomy. CONCLUSIONS: In organ-confined @entity1358 , high expression of @entity3820 was independently predictive of poorer @entity1349 after nephrectomy.
