A study of the electrochemistry and osmotic relationships of the cochlear fluids in the neonatal XXXX at the time of the development of the endocochlear potential.

@entity972 @entity9680 @entity1372 @entity653 @entity2865 @entity35
1. Changes in the endocochlear potential between the 8th and 18th days after birth were investigated in the @entity35 . Initially the potential was low but its magnitude increased rapidly between the 11th and 16th day. During the 13th and 14th days the rate of increase was approximately 1 mV/hr.2. The rapid potential increase arose virtually simultaneously in all three turns of the cochlea.3. Histological examination revealed the cochlea, including the hair cells of Corti's organ and the stria vascularis, to be fully mature before the period of rapid change in the endocochlear potential, apart from the cells of Claudius, whose final development coincided with the latter part of this phase.4. The endolymphatic @entity1372 concentration (average 1.0 m-equiv/l.) had attained the very low adult level in the earliest period studied. The @entity972 and @entity2865 concentrations were slightly below the normal adult levels, the result of some degree of general @entity9680 present at this time.5. The endolymphatic ionic concentrations remained unchanged during the phase of rapid increase in the endocochlear potential.6. The findings thus indicate that the distinctive endolymphatic ionic composition and the endocochlear potential arise largely independently and in succession during cochlear maturation.7. No differences in osmotic pressure were demonstrated between endolymph, perilymph and serum. The problems concerning the homoeostasis of the inner ear fluids do not consequently seem to be complicated by unusual hydrodynamic aspects.8. Alterations in body fluid osmolality, produced by intraperitoneal injection of water or hypertonic @entity653 , were accompanied by simultaneous changes in the osmotic pressures of the inner ear fluids. Some portion of the membranes bounding the endolymphatic space is therefore considered to be freely permeable to water.9. The investigations provide no further information about the nature of the endocochlear potential, although an increase in the electrical resistance of the cochlear duct membranes is thought responsible for its appearance. The time relationships of this period support the concept that the potential is an essential feature of the mechano-electric transduction process.
