Ocular Surface and Tear Film Changes in Older XXXX Working with Computers.

@entity1 @entity2194 @entity71074 @entity9539
UNASSIGNED: The aim of this work is to investigate changes in the @entity2194 ( @entity2194 ) and tear film (TF) by means of questionnaire-based subjective symptoms, TF break-up time, Schirmer test, and TF analysis in @entity1 working with computers and to analyze the effects of the oral supplementation with antioxidants/ @entity9539 (A/  3) in the @entity2194 outcomes. @entity1 aged 40-65 years (n = 148) were recruited at the Administrative Offices of Valencia (Spain) and distributed into two age groups, 40-52 years (AGE1; n = 87) and 53-65 years (AGE2; n = 61), and then subdivided according to being (or not) computer users (CUG; NCUG) during the workday. Homogeneous subgroups were randomly assigned (or not) to the daily intake of three pills of A/  3 for three months. At baseline and at the end of follow-up, personalized interviews and ocular examination were done. Reflex tear samples were collected from the inferior meniscus and processed for a multiplexed particle-based flow cytometry assay to measure proinflammatory molecules. Statistics were performed using the SPSS 15.0 program. The @entity2194 pathology was clinically evident in the AGE1-CUG (33%) versus the AGE2-CUG (64%) of @entity1 . Significantly higher @entity71074 tear levels were found in the AGE1 versus the AGE2 @entity1 employees (P = 0.006 and P = 0.001, resp.), as well as in the CUG versus the NCUG (P = 0.001 and P = 0.000, resp.). Supplementation with A/  3 positively influenced the @entity2194 pathology as manifested by the amelioration of the clinical signs/symptoms related to computer uses. Strategies involving a safe environment and oral micronutrient supplements may be managed within eye-care standards in older @entity1 .
