Sensitivity and specificity of the XXXX : clinical judgment of standard printouts versus the number.

@entity1 @entity9999 @entity735 @entity726
PURPOSE: The Number is a standard parameter of the @entity9999 that reportedly distinguishes normal and @entity735 . The authors evaluated the sensitivity and specificity of the Number and examined whether expert clinical judgment of @entity9999 printouts leads to a better separation. MATERIALS AND METHODS: Two experienced observers judged 800 @entity9999 scans on 400 randomly presented printouts from 200 @entity726 @entity1 and 200 age-matched normal subjects. The diagnosis was based on the symmetry analysis printout and was per @entity1 rather than per eye. The observers assessed sensitivity for all @entity726 @entity1 together, and separately for mild, moderate, and severe @entity726 . Their specificity was determined in the group of normal subjects. The same procedure was performed for the Number, at various critical values. RESULTS: Both observers discriminated better than the Number. At a critical value of 23, the specificity of the Number was 81.5%, which matched the lowest specificity of the 2 observers: 82.5% and 92.0% for observers 1 and 2, respectively. At these specificities, the sensitivity of the 2 observers and of the Number were 92.0%, 89.5%, and 85.5%, respectively. The sensitivity increased with the severity of @entity726 . The Kappa values for intraobserver agreement were 0.80 and 1.0. CONCLUSIONS: The Number yielded acceptable sensitivity and specificity values at a critical value of 23 in this test population. However, the clinical judgments of the printouts by both expert observers resulted in a better separation between normal and @entity735 , particularly in the group with mild @entity726 .
