Monozygotic twins discordant for XXXX .

@entity1 @entity154 @entity8541 @entity4802 @entity4239 @entity649 @entity215 @entity735 @entity386
OBJECTIVE: To report on a pair of monozygotic female twins discordant for @entity4802 . DESCRIPTION: The affected twin was a @entity1 , who was delivered by caesarean section at 35 weeks' gestation. Her birth weight was 2,170 g, length 42.5 cm, head circumference 30 cm and her Apgar scores were 3/7. After birth the @entity1 developed severe @entity649 and had to be moved to the neonatal intensive care unit (ICU). The other twin was a @entity1 , born weighing 3,200 g with a length of 49 cm, head circumference of 34 cm and Apgar scores of 8/10. She was transferred to the mother-baby unit soon after birth and was discharged two days later. There was no consanguinity between the twins' parents, who were young and healthy at the time of their conception. The affected @entity1 's @entity154 included left @entity4802 , severe @entity4239 , abnormal ears, bilateral @entity8541 and epibulbar @entity735 . She developed obstructive @entity386 due to @entity4239 and required tracheostomy. Abdominal and cranial ultrasound findings were normal, as was an ophthalmological assessment. Spine x-ray showed hemivertebra at T9 and T10. An echocardiogram showed @entity215 . GTG-banded karyotyping was performed on peripheral blood cells and revealed 46,XX. Zygosity testing established the pair of twins to be monozygotic with a probability greater than 99:1. COMMENT: @entity4802 was diagnosed in one of the twins described here. There are several reports of twins discordant for this disorder and therefore non-genetic factors may also play an important role, for instance vascular disruption during morphogenesis.
