Prognostic factors and risk group analysis in follicular XXXX .

@entity1 @entity66 @entity5 @entity3 @entity259
BACKGROUND: The understanding of prognostic factors has facilitated stratification of risk groups in differentiated @entity259 . The prognostic factors have clearly identified the risk groups as low, intermediate, and high risk. Risk group categorization has facilitated a selective surgical approach for @entity259 . METHODS: A retrospective review of 228 @entity1 with follicular @entity259 was undertaken. Various prognostic factors and risk groups were analyzed. Univariate and multivariate analyses were performed, and the survival curves were plotted by the Kaplan-Meier method. Fifty-nine (26%) @entity1 presented with H  rthle cell histology. The risk groups revealed 62 @entity1 in the low, 84 in the intermediate, and 82 in the high risk groups. RESULTS: The 10-year survival for low, intermediate, and high risk groups was 98%, 88%, and 56%, respectively, and the 20-year survival for the same groups was 97%, 87%, and 49%, respectively. Adverse prognostic factors included age older than 45 years (p < 0.001), H  rthle cell variety (p = 0.05), extrathyroidal extension, @entity5 size exceeding 4 cm, and the presence or absence of distant @entity3 (p < 0.001). Gender, focality, and presence of lymph node @entity3 had no significant impact on prognosis. CONCLUSIONS: @entity1 in the low risk group have excellent survival, whereas the high risk group behaves poorly. Appropriate selection of treatment for the @entity66 and adjuvant therapy should be considered on the basis of the prognostic factors and risk group analysis.
