Sequential @entity1487 and @entity1499 . Negative experience in metastatic XXXX .

@entity1 @entity4181 @entity137 @entity1500 @entity14 @entity1499 @entity1487
Forty-two @entity1 with measurable advanced @entity14 were treated with sequential @entity1499 ( @entity1500 ) and @entity1487 ( @entity1487 ), followed by @entity4181 rescue. Twenty-one @entity1 had received prior chemotherapy, mainly @entity1487 (group 1) and remaining 21 @entity1 had not been previously treated by cytotoxic agents (group 2). Two different treatment schedules were used. Regimen I (27 @entity1 ): @entity1500 250 mg/m2 was infused over 1 hour. Two hours from start @entity1487 600 mg/m2 was given as intravenous bolus. @entity4181 rescue started 24 hours after @entity1500 infusion. Regimen II (15 @entity1 ): @entity1500 250 mg/m2 was given as 1-hour infusion. Three hours after the start of @entity1500 a 46-hour @entity1487 infusion (2000 mg/m2) was started. @entity4181 rescue as in regimen I. The chemotherapy courses were repeated every second week. After 3 cycles only one @entity1 had partial response, 33 had no change and 8 progressive disease. The median time until progression was 2 1/2 months in group 1 and 4 months in group 2. The median survival was 7 months in group 1 and 10 1/2 months in group 2. Almost identical results were obtained by the two treatment schedules. The @entity137 of both regimens was low.
