Familial relationships between obesity and XXXX .

@entity2175 @entity413 @entity6
Obesity and family history of @entity6 are both risk factors for @entity2175 ( @entity2175 ), but it has been proposed that lean individuals with @entity2175 have a greater load of @entity6 susceptibility genes. If this is the case, one might expect a high prevalence of @entity2175 in relatives of @entity6 individuals with a low body mass index (BMI). Among Pima Indians participating in an epidemiological study, prevalence of @entity2175 was evaluated in relation to BMI of a @entity6 parent or to the average parental BMI when both parents had @entity6 in 1,535 offspring from 547 families. Prevalence of @entity2175 was also evaluated in relation to BMI of a randomly selected index @entity6 sibling in 1,722 siblings from 721 families. @entity2175 was diagnosed by an oral @entity413 tolerance test. Compared with offspring of @entity6 parent(s) at the 25th percentile of BMI, the odds ratio (OR) for @entity6 in offspring of @entity6 parents at the 75th percentile was 0.6 (95% confidence interval [CI] 0.5-0.7), adjusted for age, sex, BMI in offspring, number of @entity6 parents, and age at onset of @entity6 and sex of the @entity6 parent(s). In the analysis according to BMI in a @entity6 sibling, the corresponding OR was 0.8 (95% CI 0.6-0.9). Risk ratios were only modestly higher when the analysis was restricted to relatives of subjects whose BMI had been determined before the onset of @entity6 . @entity2175 in the presence of a low BMI is more strongly familial than that at a higher BMI.(ABSTRACT TRUNCATED AT 250 WORDS)
