[Temporal changes and interaction of serum cytokines in XXXX with acute @entity583 undergoing primary percutaneous coronary intervention].

@entity1 @entity650 @entity2842 @entity741 @entity583 @entity687 @entity688
OBJECTIVE: To investigate the temporal changes of serum cytokines @entity650 , @entity687 , @entity2842 and @entity688 immediately before and after primary PCI (percutaneous coronary intervention) in @entity1 with @entity583 ( @entity583 ) and explore the interaction of these cytokines. METHODS: A total of 59 @entity583 @entity1 were recruited. And their serum concentrations of @entity650 , @entity687 , @entity2842 and @entity688 were measured by ELISA before primary PCI and 4-6 hours, 12 hours, 24 hours and 7 days post-intervention. For each cytokine, the level at each time-point post-PCI was compared to that at pre-PCI. Correlation coefficient test was used to analyze the interactions of these four cytokines. RESULTS: At 12 hours post-PCI, the median serum levels of @entity650 and @entity687 were higher than those before PCI ( @entity650 : 8.51 ng/L vs 6.76 ng/L, @entity687 : 4.67 ng/L vs 2.95 ng/L, both P < 0.05). At 4-6 hours and 12 hours post-PCI, the median values of @entity2842 were increasing significantly compared to those at pre-PCI (35.04 ng/L, 34.24 ng/L vs 30.45 ng/L, both P < 0.05) while those of @entity688 decreased (18.15 ng/L, 18.82 ng/L vs 20.95 ng/L, both P < 0.05). The levels of @entity650 and @entity688 at pre-PCI were associated with the Killip classification on admission ( @entity650 : r = 0.293, P < 0.05; @entity688 : r = -0.287, both P < 0.05). Except for @entity687 , other cytokines had no significant relation with the time length from onset to admission (P > 0.05). Additionally, these four cytokines were not found to be related with the location and extension of @entity583 , ejection fraction and NT-proBNP. At each time-point, there were a positive relationship among the natural logarithms of the concentrations of @entity650 , @entity687 and @entity2842 (P < 0.01), all of which were inverse to the natural logarithm of the concentration of @entity688 (P < 0.01). CONCLUSIONS: The pro-inflammatory cytokines increase while the anti-inflammatory cytokines decrease after @entity741 /reperfusion. An imbalance of inflammatory cytokines may be present.
