Adverse effects of local anaesthetics - @entity566 , toxic reactions or XXXX .

@entity1 @entity3406 @entity566 @entity3303 @entity56 @entity1445
BACKGROUND: There are several kinds of adverse reactions to the administration of local anaesthetics (LAs): @entity56 , which causes reproducible symptoms or signs, initiated by exposure to a defined stimulus at a dose tolerated by normal subjects; toxic reactions - caused by @entity1445 or inappropriate administration; and @entity566 - when an immunologic mechanism can be shown to be important.The most serious adverse reaction is anaphylaxis, which can be of allergic or non-allergic (anaphylactoid) origin. We analysed clinical adverse reactions to local anaesthetic agents that occurred in the Silesian region. METHODS: Thirty-two @entity1 , aged 22-56 years, in whom significant reactions had occurred after administration of an LA, were investigated in our institution. The investigation was based on skin prick, intradermal injections and patch testing. In every @entity1 , the concentration of latex IgE antibodies was measured. RESULTS: True @entity56 were confirmed in three @entity1 . The allergens were: @entity3303 in all three cases, additionally: @entity3406 - in one @entity1 and preservative (paraben) - in one @entity1 . No latex @entity566 was diagnosed. DISCUSSION: The results showed that @entity56 to LA agents are rare and that most of the reported reactions were caused by @entity56 . Nevertheless, in each case of adverse reaction, careful review of the history, and testing of immediate and @entity56 not only to LA but also to latex and preservatives, should be mandatory.
