XXXX of the upper aerodigestive tract. A case comparison analysis.

@entity1 @entity286 @entity5 @entity167 @entity957
Although the etiologic importance of @entity286 in risk of upper aerodigestive @entity5 is unquestioned, quantification of subsite-specific risks is less well delineated. Risk estimates from this case-control study are derived from self-administered comprehensive risk factor questionnaires distributed to newly registered @entity1 at The University of Texas M.D. Anderson Hospital and @entity5 Institute, Houston. Cases included 185 white @entity1 with histologically confirmed @entity957 of the upper aerodigestive tract. An equal number of age-frequency and sex-frequency matched @entity1 was randomly selected from the same @entity1 population excluding only @entity1 with diagnoses of @entity957 of any site. A statistically significant dose-response relationship for three categories of cigarette pack-years was evident for both males (odds ratios [OR] = 1.8, 4.0, and 7.5) and females (OR = 1.5, 9.0, and 12.0). Highest risks were documented for @entity5 (OR = 15.1) and lingual cancer (OR = 14.5). There was interaction between @entity167 use and smoking among @entity1 , but no independent effect of @entity167 consumption among either gender. After 15 years of smoking abstinence, males no longer exhibited increased risk (OR = 1.0) whereas the risk for females after 15 years of cessation was 1.5. There were also significantly increased risks among @entity1 associated with snuff dipping, cigar, and pipe use (OR = 3.4, 2.8, and 1.8, respectively). The differences in the magnitude of the risk estimates and dose-response curves by subsite and by sex suggest a variable susceptibility to carcinogenic action.
