Pathophysiology of XXXX .

@entity1 @entity712 @entity1353 @entity301 @entity26 @entity891 @entity2661 @entity121 @entity1284
@entity712 is a syndrome that can be caused by a variety of abnormalities, including pressure and @entity1284 , loss of muscle, primary @entity121 or excessive peripheral demands such as high output failure. In the usual form of @entity712 , the heart muscle has reduced contractility. This produces a reduction in cardiac output, which then becomes inadequate to meet the peripheral demands of the body. The 4 primary determinants of left ventricular (LV) performance are generally altered as follows: (1) There is an intrinsic decrease in muscle contractility. (2) Preload or left atrial filling pressure is increased, resulting in @entity891 and @entity1353 . (3) Although systemic blood pressure is often reduced, there is an increase in systemic vascular resistance (afterload), which can further reduce cardiac output. (4) Heart rate is generally increased as part of a compensatory mechanism associated with an increase in sympathetic tone and circulating @entity2661 . In @entity1 with @entity301 , there is often an imbalance between myocardial @entity26 supply and demand. An increase in heart size may be particularly deleterious by increasing wall tension because of the Laplace relation and increasing myocardial @entity26 consumption.(ABSTRACT TRUNCATED AT 250 WORDS)
