Study of direct immunofluorescence, immunofluorescence mapping and light microscopy in @entity6050 XXXX .

@entity1 @entity10921 @entity3161 @entity503 @entity6050
BACKGROUND: Even though @entity6050 @entity10921 is the most frequent type of @entity6050 , there are few studies about its cutaneous physiopathology. OBJECTIVE: To evaluate skin changes in @entity6050 @entity10921 using light microscopy and direct immunofluorescence before and after treatment with @entity503 . To perform antigen immunomapping of bullae to study their level of cleavage. METHODS: Light microscopy and direct immunofluorescence of 28 @entity1 are reported in three different phases: 23 @entity1 with active @entity6050 before treatment (Phase A), 7 @entity1 with clinical remission during treatment (Phase B), and 8 @entity1 with biochemical remission (Phase C). Immunomapping was performed on 7 @entity1 . RESULTS: In active @entity6050 , direct immunofluorescence showed homogenous and intense fluorescence on the inside and on the walls of blood vessels as well as in the @entity3161 . In clinical remission (Phase B) and biochemical remission (Phase C), the deposit of immunoglobulins was maintained, but the deposit of complement was reduced in most cases. Immunomapping revealed no standard cleavage plane. CONCLUSION: No correlation was observed between clinical response and immunoglobulin deposits. The reduction of complement favors the hypothesis that activation of the complement cascade represents an additional pathway that leads to endothelial damage.
