Etiology and outcome of XXXX after marrow transplantation: a prospective study.

@entity1 @entity5163 @entity294 @entity281 @entity43939 @entity2132 @entity325 @entity2718 @entity526
BACKGROUND/AIMS: Acute @entity294 after marrow transplant is usually ascribed to acute @entity2132 ( @entity2132 ) or @entity281 , with a reported 40%-50% incidence of @entity281 . The aim of this study was to determine the incidence of acute @entity294 after transplantation, its causes, and its outcome. METHODS: Two hundred ninety-six @entity1 were followed up; @entity1 with @entity294 were studied using standard evaluation of stool plus immunoelectron microscopy; assays for astrovirus, picobirnavirus, and @entity43939 ; and gene-probe methods for toxin-producing @entity526 . In 38 @entity1 with @entity294 , intestinal biopsy specimens and duodenal fluid were also analyzed. RESULTS: One hundred fifty acute @entity5163 developed in 126 @entity1 (an incidence of 43%). @entity281 was found in 20 of 150 episodes: viruses (astrovirus, adenovirus, cytomegalovirus, and rotavirus) in 12 @entity1 , nosocomially acquired bacteria ( @entity2718 and Aeromonas) in 7 @entity1 , and @entity325 in 1 @entity1 . Acute @entity2132 was responsible for 72 of 150 episodes (48%). Clinical signs and symptoms of @entity281 and @entity2132 were similar. In 58 of 150 episodes (39%), no clear etiology could be found for self-limited @entity294 . CONCLUSIONS: @entity281 accounted for 13% and acute @entity2132 for 48% of @entity5163 . The most common infecting organisms were astrovirus, @entity2718 , and adenovirus. Most cases of @entity294 after marrow transplant are not caused by @entity281 .
