Protective effect against focal @entity2806 in acute phase of a novel invasive device for regional XXXX .

@entity1 @entity5045 @entity64 @entity2806 @entity63 @entity35 @entity2332
BACKGROUND: Systemic @entity2332 is considered beneficial to @entity64 @entity1 . However, many complications ensue. The aim of this study was to evaluate the effect of a new invasive regional cooling device in @entity2806 in a @entity35 model. METHODS: After a pilot study confirming the efficiency of the cooling device, 15 adult male @entity35 , weighing 300-400  g, were randomly assigned into three groups: cooling device applied at 14  C and at 26  C, and a sham group. Focal @entity2806 was achieved by electrocauterization of the left middle cerebral artery through craniectomy and temporal occlusion of both common carotid arteries for 3 hours. Within 30 minutes after the end of @entity63 , the cooling device was inserted into the @entity35 brain through a stereotactic frame to provide regional @entity2332 for 2 hours. The @entity35 were sacrificed immediately after the 2-hour regional @entity2332 . RESULTS: Although @entity5045 staining showed smaller @entity2806 in both the 26  C and 14  C groups compared to the control group, Fluoro Jade C staining showed no neuroprotective effects in the rostrum cerebral cortex in both groups. However, both @entity5045 and Fluoro Jade C staining indicated significant beneficial effects in the caudal cerebral cortex in @entity35 with cooling device applied at 26  C compared to the 14  C and control groups. CONCLUSION: Our findings indicated that the device can effectively achieve regional @entity2332 and could be beneficial for @entity1 with @entity2806 during the acute phase.
