Diagnostic outcomes following childhood non-specific XXXX : a record-linkage study.

@entity1 @entity697 @entity146 @entity347 @entity29 @entity1744 @entity490 @entity30 @entity2383
AIMS: Non-specific @entity490 (NSAP) is the most common diagnosis on discharge following admission for @entity490 in childhood. Our aim was to determine the risk of subsequent hospital diagnosis of @entity347 following a diagnosis of NSAP, and to assess the persistence of this risk. METHODS: An NSAP cohort of 268   623 @entity1 aged 0-16   years was constructed from linked English Hospital Episode Statistics from 1999 to 2011. The control cohort (1   684   923 @entity1 , 0-16   years old) comprised @entity1 hospitalised with unrelated conditions. Clinically relevant outcomes were selected and standardised rate ratios were calculated. RESULTS: From the NSAP cohort, 15   515 (5.8%) were later hospitalised with bowel pathology and 13   301 (5%) with a specific @entity2383 . Notably, there was a 4.84 (95% CI 4.45 to 5.27) times greater risk of @entity30 following NSAP and a 4.23 (4.13 to 4.33) greater risk of @entity697 than in the control cohort. The risk of @entity1744 ( @entity1744 ) was 7.22 (6.65 to 7.85) times greater following NSAP. The risks of @entity29 ( @entity29 ), @entity146 (unspecified) were significantly increased in all age groups except <2-year-olds. The risk of underlying bowel pathology remained raised up to 10   years after first diagnosis with NSAP. CONCLUSIONS: Only a small proportion of those with NSAP go on to be hospitalised with underlying bowel pathology. However, their risk is increased even at 10   years after the first hospital admission with NSAP. Diagnostic strategies need to be assessed and refined and active surveillance employed for @entity1 with NSAP.
