Altered multihormone synchrony in @entity28 @entity1 with XXXX .

@entity1 @entity3610 @entity251 @entity28 @entity53 @entity1176 @entity443
Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity28 @entity1 with @entity3610 ( @entity3610 ). In addition, @entity1 have @entity3610 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity3610 are still unclear. We investigated 15 @entity3610 @entity1 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity28 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity251 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity1 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity251 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity251 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity251 secretion and fasting concentrations of @entity53 and @entity443 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity251 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity3610 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity1176 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity251 .
