Common variant in 6q26-q27 is associated with distal XXXX in an Asian population.

@entity1 @entity66 @entity73241 @entity33895 @entity5 @entity167 @entity73239 @entity73240 @entity14 @entity36684 @entity694 @entity8110
BACKGROUND AND AIM: @entity14 ( @entity14 ) is a @entity66 with both environmental and genetic factors contributing to its development. The incidence of @entity14 is increasing year by year in Japan. @entity1 with @entity14 in advanced stages have a poor prognosis, but detection of @entity14 at earlier stages can improve clinical outcome. Therefore, identification of epidemiologial factors that influence development of @entity14 would facilitate the prevention or early detection of disease. METHODS: To identify loci associated with @entity14 risk, we performed a genome-wide association study (GWAS) for @entity14 and sub-analyses by @entity5 location using 1583 Japanese @entity14 cases and 1898 controls. Subsequently, we conducted replication analyses using a total of 4809 @entity14 cases and 2973 controls including 225 Korean subjects with distal @entity694 and 377 controls. RESULTS: We identified a novel locus on 6q26-q27 region ( @entity73239 in @entity33895 , p = 7.92   10      , OR of 1.28) that was significantly associated with distal @entity694 . We also replicated the association between @entity14 and SNPs on 8q24 ( @entity36684 and @entity73240 , p = 1.51   10       and 7.44   10      , ORs of 1.18 and 1.17, respectively). Moreover, we found cumulative effects of three genetic factors ( @entity73239 , @entity36684 , and @entity73241 in @entity8110 ) and one environmental factor ( @entity167 drinking) which appear to increase @entity14 risk approximately twofold. CONCLUSIONS: We found a novel susceptible locus in @entity33895 that contributes to the risk of distal @entity694 in an Asian population. These findings would further extend our understanding of the role of common genetic variants in the aetiology of @entity14 .
