XXXX expression in a primary @entity43 : a case report.

@entity43 @entity1 @entity588 @entity548 @entity39 @entity5 @entity242 @entity55 @entity900 @entity3508 @entity2277 @entity490 @entity11090 @entity1260
BACKGROUND: Primary @entity43 is an extremely rare @entity11090 with fewer than 30 documented cases worldwide. Immunohistochemically, @entity43 are characterized by the expression of alpha-smooth muscle actin (alpha-SMA). Until recently, no report investigated the role of @entity588 expression in primary @entity43 . We report the management and an immunohistochemical analysis of @entity588 in a @entity1 with primary @entity43 . CASE REPORT: The @entity1 , a 71-year-old @entity1 , presented with a history of lower @entity490 and a palpable mass in the lower abdomen. Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa. Microscopically the left @entity5 consisted of spindle cells arranged in smooth-muscle bundles and fascicles. The @entity5 was characterized by high cellularity and nuclear polymorphism, as well as patchy @entity39 and large areas of @entity548 . Mitotic activity exceeded 5 mitoses per 10 high-power fields with many atypical mitoses. The @entity5 appeared encapsulated, and the capsule was partially disrupted by @entity5 cells. Immunohistochemically, the @entity5 showed a strong staining reaction for muscle actin, alpha-SMA and @entity3508 , and also a weak reaction for @entity2277 . Strong staining of @entity588 was detected, with more than 80% of @entity242 cells positive. According to the FIGO staging system for @entity43 , the @entity5 was classified as a primary @entity43 stage III C, and the @entity1 was treated with an adjuvant chemotherapy regimen consisting of @entity900 and @entity1260 . Two days after the third cycle of @entity900 /ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued. The @entity1 remained without evidence of disease until she died as a result of intercurrent @entity55 14 months after initial surgery. CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary @entity43 , strong staining for @entity588 was detected. In order to understand more about the nature and the behaviour of this highly malignant @entity5 and to be able to improve the treatment, the prognostic value of @entity588 has to be investigated in additional studies.
