A randomized, prospective, double-blind comparison of XXXX (Versed) and emulsified @entity3175 (Dizac) for opioid-based, conscious sedation in endoscopic procedures.

@entity1 @entity407 @entity1032 @entity3175 @entity788 @entity726 @entity1245 @entity56 @entity1363
OBJECTIVE: We completed a prospective, randomized, double-blinded clinical trial to compare the quality of sedation with two @entity1245 (emulsified @entity3175 and @entity1363 ) for endoscopic procedures. METHODS: Adult @entity1 undergoing esophagogastroduodenoscopy or colonoscopy were eligible. Exclusion criteria included: @entity56 , @entity1032 , untreated @entity726 , active @entity788 , @entity407 , resident physician training, or cases done outside the Endoscopy unit. Nurses began the sedation process by administering an opioid followed immediately by administering study drugs until @entity1 were adequately sedated. At completion of the procedure, both the physician and the nurse rated whether the @entity1 's sedation appeared to be adequate. In addition, before discharge, @entity1 were asked to rate the quality of sedation. RESULTS: A total of 111 @entity1 were randomized to the emulsified @entity3175 group and 100 to the @entity1363 group. There was no difference in the physician's assessment of quality of sedation between the groups (p > 0.05). The length of time to sedation, total procedure time, and recovery time were similar between both groups. The estimated cost of using emulsified @entity3175 was approximately 50% less than that of @entity1363 , with an equal quality of sedation. CONCLUSION: Neither the physicians, nurses, nor the @entity1 could detect a difference between sedation produced by the drugs. We conclude that both drugs were equally effective for sedation for both upper and lower endoscopic procedures. Based on the results of this trial, we suggest that increased use of emulsified @entity3175 would markedly reduce the cost without altering the quality of sedation. The cost savings would be at least  50,000/yr at our institution.
