Human GSTs polymorphisms in the Hakka population of south China and their associations with family history of several XXXX .

@entity101 @entity167 @entity102 @entity4192 @entity4191 @entity56961 @entity4193 @entity9164
OBJECTIVE: To investigate the associations of genetic polymorphisms in GSTs genes of the Hakka population of south China with family histories of certain @entity102 . METHODS: Five hundred and thirty-nine healthy Hakka natives of Meizhou city of Guangdong province in south China were involved. The genotypes of @entity9164 , @entity4192 , @entity4191 , @entity4193 , and @entity56961 were determined using PCR and restriction fragment length polymorphism analysis. The observed polymorphisms were analyzed by Chi-square and Hardy-Weinberg equilibrium tests. Logistic regression analysis was used to determine the associations of the distributions of GST genotypes with family history of certain @entity102 . RESULTS: The distributions of polymorphisms in @entity4191 , @entity4193 , and @entity56961 conformed to the Hardy-Weinberg equilibrium. Compared to the Cantonese, the Hakka had a lower distribution of the @entity4193 deletion genotype (3.15% vs. 11.9%). A weak association was observed between the @entity9164 genetic polymorphism and family history of @entity101 . @entity167 drinkers had a higher frequency of the null- @entity9164 genotype, while smokers had a higher frequency of a variant @entity4191 genotype. CONCLUSION: The results suggest that the Hakka is a special and distinctive Han Chinese ethnic group with different GSTs genetic polymorphisms. Smoking and drinking might be related to the distribution of GST genotypes.
