Critical role for @entity6026 in XXXX caused by @entity29181 .

@entity1 @entity15254 @entity32 @entity30527 @entity6026 @entity55 @entity19 @entity29181
Autophagy is an important component of the immune response. However, the functions of autophagy in @entity1 diseases are much less understood. We studied biological consequences of @entity29181 in @entity19 lacking the essential autophagy gene @entity30527 or @entity15254 in myeloid cells. Surprisingly, these @entity19 presented with spontaneous @entity55 , characterized by marked recruitment of inflammatory cells, submucosal thickening, goblet cell metaplasia, and increased collagen content. @entity55 was associated with increase in several proinflammatory cytokines in the bronchoalveolar lavage and in serum. This @entity32 was largely driven by @entity6026 as a result of constitutive inflammasome activation. Following i.p. LPS injection, autophagy-deficient @entity19 had higher levels of proinflammatory cytokines in lungs and in serum, as well as increased mortality, than control @entity19 . Intranasal bleomycin challenge exacerbated @entity55 in autophagy-deficient @entity19 and produced more severe fibrotic changes than in control @entity19 . These results uncover a new and important role for autophagy as negative regulator of @entity55 .
