The efficacy of postoperative antibiotic regimens in the open treatment of mandibular XXXX : a prospective randomized trial.

@entity1 @entity174 @entity4422 @entity114 @entity281 @entity9385 @entity3402
PURPOSE: The purpose of this study was to determine the necessity and/or effectiveness of postoperative antibiotics in the treatment of mandible @entity174 . MATERIALS AND METHODS: This study is a prospective, randomized trial composed of @entity1 who presented for operative treatment of @entity4422 and subsequently underwent open reduction and internal fixation at 1 institution. @entity174 treated by an intraoral and/or extraoral open reduction with internal fixation were included in this study. The @entity1 were randomly divided into 2 groups based on whether or not they received postoperative antibiotics. Both groups received preoperative antibiotics of various regimens as well as intraoperative antibiotics on the day of surgery. Group Ab @entity1 received 2.4 mIU of intramuscular @entity114 G @entity9385 , or if allergic, a 5- to 7-day regimen of oral @entity3402 . Group non-Ab @entity1 received no antibiotics postoperatively. @entity1 followed between 5 and 8 weeks were included in the data set. RESULTS: A total of 291 @entity1 were enrolled in the study, of which 181 @entity1 met the inclusion criteria. Group Ab included 81 and group non-Ab 100 @entity1 . Twenty-two @entity1 had evidence of @entity281 noted within the 8-week follow-up period. There were 8 @entity281 in group Ab and 14 @entity281 in group non-Ab. Statistical analysis with the Pearson Chi-square and Student's t test showed no statistically significant difference (P = .399) between groups Ab and non-Ab. CONCLUSION: This study could not prove any statistically significant benefit to the administration of postoperative antibiotics in @entity1 undergoing open reduction and internal fixation of mandibular @entity174 .
