Pulmonary vascular response to leukotriene D4 in unanesthetized @entity742 : role of XXXX .

@entity2871 @entity742 @entity2404 @entity7489 @entity8304 @entity358 @entity16982
We examined the pulmonary vascular response to an intravenous leukotriene D4 (LTD4) injection of (1 microgram X kg-1 X min-1 for 2 min) immediately followed by infusion of 0.133 microgram X kg-1 X min-1 for 15 min in awake @entity742 prepared with lung lymph fistulas. LTD4 resulted in rapid generation of @entity2404 as measured by an increase in plasma @entity7489 concentration. The @entity7489 generation was associated with @entity358 while left atrial pressure did not change significantly. Pulmonary lymph flow (Qlym) increased (P less than 0.05) transiently from base line 6.87 +/- 1.88 (SE) ml/h to maximum value of 9.77 +/- 1.27 at 15 min following the LTD4 infusion. The maximum increase in Qlym was associated with an increase in the estimated pulmonary capillary pressure. The increase in Qlym was not associated with a change in the lymph-to-plasma protein concentration (L/P) ratio. Thromboxane synthetase inhibition with @entity16982 (an @entity8304 derivative) prevented @entity7489 generation after LTD4 and also prevented the increases in pulmonary vascular pressures and Qlym. We conclude that LTD4 in awake @entity742 increases resistance of large pulmonary veins. The small transient increase in Qlym can be explained by the increase in pulmonary capillary pressure. @entity2871 appears to mediate both the pulmonary hemodynamic and lymph responses to LTD4 in @entity742 .
