The effects of XXXX and @entity3858 , singly and in combination, on systemic haemodynamic responses to @entity1151 .

@entity3858 @entity117 @entity95 @entity2918 @entity1151 @entity551 @entity887 @entity750 @entity204
Pretreatment of anaesthetized @entity95 with @entity117 (A), 250 mg.kg-1, @entity3858 (M) 3 mg.kg-1 or a combination of both (A + M) was done before @entity1151 with a 1.0 ml autologous blood clot and compared with no pretreatment (C). Experiments were done until 10 survivors were present in each group. Mortality rate in controls (C) was 55 per cent ( @entity204 in less than 30 minutes) compared to zero in (A) and (A + M) and nine per cent in (M). Arterial blood pressure fell to 60 per cent of pre- @entity887 values two minutes after @entity887 in (C) but had returned to 85 per cent of pre- @entity887 values after 60 minutes. This compares with a drop to 82 per cent at two minutes and 83 per cent at 60 minutes in (A), a drop to 70 per cent at two minutes and 90 per cent at 60 minutes in (M) and a very small drop to 92 per cent at two minutes which was unchanged at 60 minutes in (A + M). Right ventricular pressure increased by 75 per cent after two minutes compared to pre- @entity887 values in (C) and was still elevated by 37 per cent after 60 minutes. This compares with increases at two minutes and 60 minutes respectively of 58 and 23 per cent in (A), 65 and 35 per cent in (M) and 55 and 18 per cent in (A + M). Heart rate did not show any significant changes in any of the groups after @entity887 . These results show a dramatic reduction in mortality from @entity1151 with @entity117 or @entity3858 pretreatment, which is associated with significant attenuation of the @entity551 response seen in controls. These agents may act by inhibiting the actions of a release of @entity2918 and @entity750 . The additive effects of the combination used suggests that both mediators may play a role in the haemodynamic responses to @entity1151 .
