XXXX negatively correlates with @entity1575 as detected by histology and FibroScan.

@entity1 @entity2835 @entity82 @entity1560 @entity1575 @entity3928 @entity409 @entity991 @entity2853 @entity10017 @entity157 @entity3929 @entity494 @entity15453 @entity10074 @entity31219 @entity3619 @entity99 @entity14908 @entity775
AIM: To investigate whether expression of selected miRNAs obtained from fibrotic liver biopsies correlate with @entity82 stage. METHODS: Altogether, 52 @entity1 were enrolled in the study representing various etiologic backgrounds of @entity82 : 24 cases with @entity3619 (types B, C), 19 with @entity409 ( @entity775 , @entity2835 , @entity991 , @entity3928 cases), and 9 of mixed etiology (alcoholic and nonalcoholic @entity1560 , cryptogenic cases). Severity of @entity82 was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNA isolation, expression levels of @entity10017 , @entity2853 , @entity15453 , @entity494 , @entity10074 , and @entity14908 were determined using TaqMan MicroRNA Assays applying @entity31219 as the reference. Selection of miRNAs was based on their characteristic up- or downregulation observed in @entity157 . Relative expression of miRNAs was correlated with @entity82 stage and @entity409 ( @entity409 ) value measured by transient elastography, as well as with serum @entity3929 aminotransferase (ALT) level. RESULTS: The expression of individual miRNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of @entity2853 in stage F4 was statistically significant (P < 0.04). When analyzing miRNA expression in relation to @entity82 , levels of @entity2853 and @entity494 showed negative correlations with @entity82 stage, and @entity2853 was found to correlate negatively and @entity14908 positively with @entity409 values (all P < 0.05). ALT levels displayed a positive correlation with @entity10017 (P < 0.04). Negative correlations were observed in the @entity82 samples of mixed etiology between @entity2853 and @entity82 stage and @entity409 values (P < 0.05), and in the samples of chronic @entity99 , between @entity494 and @entity82 stage (P < 0.01), whereas @entity10017 showed positive correlation with ALT values in the samples of @entity409 (P < 0.03). The results also revealed a strong correlation between @entity82 stage and @entity409 values (P < 0.01) when etiology of @entity82 was not taken into account. CONCLUSION: Reduced expression of @entity2853 in advanced @entity82 and its correlation with @entity82 stage and @entity409 values seem to be characteristic of @entity1575 of various etiologies.
