Study of the immune response engendered by differents combined measles, XXXX and @entity2462 (MMR) vaccines in an area of Andalusia (Spain).

@entity1 @entity2462 @entity11159 @entity20436
The objective of the study is to evaluate and compare the degree of serological protection conferred by the three components of two MMR vaccines: "Vac triple @entity11159 " (Aventis Pasteur @entity11159 ) and "Triviraten" (Berna), and to study the effects of a second dose of "Priorix" (Glaxo SmithKline), in an unprotected population. In March 2001, this study was conducted in a sample of 86 @entity1 aged 3 and 4 years, in two Basic Health Zones of C  diz (Spain). Mumps, measles and @entity2462 antibody titers were evaluated by IgG enzyme linked immunosorbent assay (ELISA). All the @entity1 showing lack of response were revaccinated with the vaccine "Priorix" of GSK; in 12 of these @entity1 (all vaccinated previously with "Triviraten"), studies confirmed the existence of seroconversion utilizing the same methodology. The most outstanding finding has been the low percentage of @entity1 vaccinated with "Triviraten" possessing protective titers (>1:500) against @entity20436 (14.3%) compared with those vaccinated with "Vac triple @entity11159 " (81.1%, P<0.000001); geometric mean values (GMT) of 164 and 1631, respectively, were obtained. Significant differences, and in the same direction, were also found in respect of measles (83.7 and 100%, and GMT of 889 and 5076), although not so striking. However, all the @entity1 studied did have protective titres (>16UI/ml) of antibodies against @entity2462 . Of the 12 @entity1 studied who had not responded with protective titers of anti- @entity20436 antibodies, eight @entity1 (66.7%) showed seroconversion with "Priorix", and only one @entity1 (25%) presented seroconversion in the response to measles. We have thus proved that the "Rubini" strain provides insufficient protection against @entity20436 in our @entity1 population. We have also found that the "Edmonston-Zagreb" strain confers less protection against measles than the "Enders" strain, although the "Schwarz" strain, after revaccination of the @entity1 who had failed with the "Edmonston-Zagreb" strain, did not achieve a satisfactory seroconversion, either.
