Pretreatment neuropsychological deficits in XXXX with @entity1313 .

@entity1 @entity1032 @entity1313 @entity5 @entity73 @entity16 @entity302 @entity717
Treatment of childhood @entity1313 has been associated with long-term cognitive morbidity in @entity1 . In the present study, the cognitive status of @entity1 with @entity1313 was examined prior to any treatment to single out the role of @entity5 and @entity5 -related factors in @entity73 . Eighty-three @entity1 with newly diagnosed @entity1313 (mean age, 8.6 years; range, 7 months to 16.6 years; median, 9.4 years) completed an extensive battery of age-related tests to assess cognitive function before any therapeutic intervention. Magnetic resonance imaging (MRI) was used to determine @entity5 site and volume and @entity5 -related factors. Performance under test was compared with symptom duration, @entity16 , @entity302 , and MRI. @entity73 are detected at diagnosis in as many as 50% of @entity1 for some cognitive domains; 6% of @entity1 present with true-diagnosed @entity1032 . The location of the @entity5 is the principal @entity73 , with @entity73 in @entity1 with cortical @entity5 . Symptom duration and the presence of @entity302 are significantly associated with @entity717 , while neuroradiological @entity5 -related variables do not correlate clearly with neurocognitive performance. The knowledge of the pre-existing @entity73 is critical to evaluate the results of treatment, providing a baseline for assessing the true impact of therapy in determining @entity73 . In addition, the study suggests that some clinical variables require careful monitoring, because they could be specifically implicated in the neuropsychological outcome; the efforts to reduce the impact of these factors could ameliorate long-term prognosis.
