Stratified neutrophil-to-lymphocyte ratio accurately predict mortality risk in @entity157 XXXX following curative liver resection.

@entity1 @entity5 @entity93 @entity157 @entity715 @entity1349
OBJECTIVES: Neutrophil lymphocyte ratio (NLR) has been shown to predict prognosis of @entity5 in several studies. This study was designed to evaluate the impact of stratified NLR in @entity1 who have received curative liver resection (CLR) for @entity157 ( @entity157 ). METHODS: A total of 1659 @entity1 who underwent CLR for suspected @entity157 between 2007 and 2014 were reviewed. The preoperative NLR was categorized into quartiles based on the quantity of the study population and the distribution of NLR. Hazard ratios (HRs) and 95% confidence intervals (CIs) were significantly associated with @entity1349 ( @entity1349 ) and derived by Cox proportional hazard regression analyses. Univariate and multivariate Cox proportional hazard regression analyses were evaluated for association of all independent parameters with disease prognosis. RESULTS: Multivariable Cox proportional hazards models showed that the level of NLR (HR = 1.031, 95%CI: 1.002-1.060, P = 0.033), number of nodules (HR = 1.679, 95%CI: 1.285-2.194, P<0.001), @entity715 (HR = 4.329, 95%CI: 1.968-9.521, P<0.001), microvascular invasion (HR = 2.527, 95%CI: 1.726-3.700, P<0.001) and @entity93 score (HR = 1.675, 95%CI: 1.153-2.433, P = 0.007) were significant predictors of mortality. From the Kaplan-Meier analysis of @entity1349 ( @entity1349 ), each NLR quartile showed a progressively worse @entity1349 and apparent separation (log-rank P=0.008). The highest 5-year @entity1349 rate following CLR (60%) in @entity157 @entity1 was observed in quartile 1. In contrast, the lowest 5-year @entity1349 rate (27%) was obtained in quartile 4. CONCLUSIONS: Stratified NLR may predict significantly improved outcomes and strengthen the predictive power for @entity1 responses to therapeutic intervention.
