P2X(2) purine receptor immunoreactivity of intraganglionic laminar endings in the XXXX gastrointestinal tract.

@entity19 @entity21 @entity4494
The distribution of P2X(2) purine receptor subunit immunoreactivity has been investigated in the @entity19 gastrointestinal tract. Immunoreactivity occurred in intraganglionic laminar endings (IGLEs) associated with myenteric @entity21 throughout the gastrointestinal tract. In the esophagus, IGLEs supplied every myenteric @entity4494 . The proportion of @entity21 supplied decreased from 85% in the stomach to 10% in the ileum, and from 50% in the caecum to 15% in the distal colon. There was substantial loss of IGLEs from myenteric @entity21 of all abdominal regions after bilateral subdiaphragmatic section of the vagus nerves. IGLEs in the esophagus consisted of dense clusters of punctate immunoreactive varicosities. In the stomach and duodenum they had prominent lamellar processes and irregular, but smaller, lamellae were found in other regions. Rare immunoreactive IGLEs occurred in the submucosa of the distal colon. P2X(2) receptor immunoreactivity was on the surfaces and in the cytoplasm of a minority of nerve cells in myenteric @entity21 . It is concluded that P2X(2) purine receptor immunoreactivity is a feature of IGLEs in the @entity19 , and that P2X receptor agonists may modulate sensitivity of the IGLEs.
