@entity17212 -eluting stent for prevention of neointimal growth: an intravascular ultrasound analysis from the Study to COmpare XXXX rate between QueST and QuaDS-QP2 (SCORE).

@entity1 @entity731 @entity17212 @entity256
BACKGROUND: Inhibition of neointimal tissue growth has been demonstrated in preliminary @entity1 feasibility studies with a stent-based polymer sleeve delivering @entity17212 . The Study to COmpare @entity256 rate between QueST and QuaDS-QP2 (SCORE) trial is a @entity1 , randomized, multicenter trial comparing @entity17212 (QP2)-eluting stents (qDES) with bare metal stents (BMS) in the treatment of de novo coronary lesions. The purpose of this substudy was to evaluate the acute expansion property and long-term neointimal responses of qDES compared with BMS as assessed by intravascular ultrasound (IVUS). METHODS AND RESULTS: A total of 122 (qDES 66, BMS 56) @entity1 were enrolled into the IVUS substudy. All IVUS images (immediately after the procedure and at 6-month follow-up) were analyzed at an independent core laboratory in a blind manner. At baseline, qDES achieved stent expansion similar to BMS. At follow-up, qDES showed reduced neointimal growth by 70% at the tightest cross section and by 68% over the stented segment (P<0.0001 for both), resulting in a significantly larger lumen in qDES than in BMS. Unlike intracoronary brachytherapy, there was no evidence of negative edge effects, unhealed dissections, or late stent-vessel wall malapposition over the stented and adjacent references segments in either group. CONCLUSIONS: Detailed IVUS analysis revealed that qDES had comparable acute mechanical and superior long-term biological effects to BMS. Although the long-term benefits and limitations of this technology require further investigation, the reduction in neointimal thickenings demonstrated that local delivery of @entity17212 through polymer sleeves augments conventional mechanical treatment of @entity731 .
