[Effects of chronic administration of XXXX on vascular reactivity of the @entity35 aorta].

@entity101 @entity35 @entity1854 @entity3371 @entity112 @entity1811 @entity857 @entity1063 @entity934
The vascular endothelial function is altered in certain vascular pathology such as @entity101 . However, the endothelial effect of the pharmacologic treatment of this pathology with @entity1811 ( @entity1811 ) inhibitor is poorly understood. To evaluate the effects of long-term treatment of @entity3371 on the @entity35 aortic vascular reactivity, 2 groups of spontaneously @entity101 @entity35 (SHR) (n = 6) were studied for 12 weeks: the first group was treated with @entity3371 (CAP) (2 g/l of water) while group 2 (OCAP) received no treatment. A third group without @entity101 was considered as control group (CTL). At the end of the experiments, isolated aortic rings were studied in organ chambers for endothelial and smooth muscle vascular reactivity. The endothelial-dependent relaxations (EDR) to cumulative doses of @entity934 , @entity112 or @entity857 were significantly decreased in the aortic segments of CTL compared to CAP (p < 0.05). Aortic segments from OCAP group demonstrated intermediate EDR responses between CAP and CTL groups. Smooth muscle relaxation to @entity1854 was comparable among the 3 groups. Maximal smooth muscle contraction to progressive doses of @entity1063 was significantly higher in the CTL group compared to the @entity101 groups. CONCLUSION: Spontaneously @entity101 @entity35 have an increased basal vascular tone. The increased EDR observed with @entity101 partially compensates this hypercontractility. Chronic @entity101 treatment with @entity3371 partially normalizes EDR responses in the @entity35 aorta suggesting the lost of the endothelial compensatory mechanism by @entity1811 inhibitors.
