Does bile protect or damage interstitial Cajal-like cells in the XXXX gallbladder?

@entity1 @entity1085 @entity788 @entity19 @entity1157 @entity5990 @entity2467
the etiology of @entity5990 is considered to be multifactorial, including biliary cholesterol hypersecretion, supersaturation and crystallization, stone formation, @entity1157 and mucus hypersecretion and gel formation. @entity1085 seems to be a key process that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile. the purpose of the current study was to determine whether ICLCs in the gallbladder were influenced by lithogenic bile. Gallbladder specimens were collected from 30 @entity1 (8 males and 22 females) who underwent elective laparoscopic cholecystectomy for symptomatic @entity5990 . The control group consisted of 25 consecutive @entity1 (11 males and 14 females) who received elective treatment for @entity788 . ICLCs were visualized in paraffin sections of gallbladders using double immunofluorescence protocol with monoclonal @entity2467 antibodies and mast cell tryptase. Cholesterol, phospholipid and bile acid concentrations were measured in bile samples obtained by needle aspiration from the gallbladder at the time of surgery. The number of ICLCs in the gallbladder wall was significantly lower in the study group than in the control group (3. @entity19 .23 vs. 7.06    1.82 cell/FOV in the muscularis propria, P < 0.001) and correlated with a significant increase in the cholesterol saturation index. The glycocholic and taurocholic acid levels were significantly elevated in the control subjects compared with the study group. The results suggest that bile composition may play an important role in the reduction of ICLC density in the gallbladder.
