@entity8189 , unlike @entity11486 , increases significantly during XXXX and during later metastasis to lymph nodes.

@entity1 @entity8189 @entity189 @entity876 @entity72479 @entity14 @entity3 @entity652 @entity11486 @entity1141 @entity2513
In collaboration with @entity876 , cyclins @entity72479 regulate the G2/M transition, a key checkpoint in the active cell cycle, which can be monitored by Ki67. However, the @entity8189 expression remains unclear during @entity14 and during later metastasis to lymph nodes, and @entity11486 expression is not clear in @entity14 . To clarify the variations of the two cyclins in @entity14 , @entity8189 , @entity11486 , @entity876 , and Ki67 were immunohistochemically stained in 22 normal mucosa, 62 @entity652 , 17 @entity189 in @entity652 , 194 @entity189 , and 21 lymph node @entity3 ; and the two cyclins were examined by Western blot in other 10 @entity189 . Located in cytoplasms, nuclei or both, @entity8189 expression increased significantly from normal mucosa through @entity2513 , from @entity652 with mild @entity1141 through those with moderate to those with severe, from peripheral @entity2513 , and from primary to metastatic foci. These increased expressions were confirmed by Western blot. @entity8189 expression, however, declined significantly in @entity189 showing large size, mucinous type, deep invasion, or short postoperative- @entity1 -survival time. High @entity8189 was linked to high @entity876 in @entity652 , and to high Ki67 in @entity652 and @entity189 . In contrast, found limited to nuclei, @entity11486 expression did not vary significantly from normal mucosa through to metastatic @entity189 , and was not associated with clinicopathological parameters, @entity876 or Ki67. The unchanged expressions were confirmed by Western blot. Thus, increased @entity8189 , but not @entity11486 , may promote @entity14 and later metastasis to lymph nodes.
