Expression of adhesion molecules and epithelial-mesenchymal transition factors in XXXX of the colorectum.

@entity3670 @entity5962 @entity189 @entity3546 @entity8945 @entity420
@entity189 ( @entity189 ) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 @entity420 ( @entity420 ). The expressions of membranous @entity5962 (P < .0001), @entity3546 (P < .0001) and @entity3670 (P = .0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the @entity420 . @entity5962 membranous expression was also significantly preserved in the central portion of the MCs (P = .0178). Nuclear @entity3546 expression in both the central portion (P = .0463) and invasive front (P = .0346) of the MCs was significantly less frequent compared to that in the @entity420 . Snail (P = .0035) and @entity8945 (P = .0463) expressions in the invasive front of the MCs were significantly less frequent compared to the @entity420 , suggesting that the EMT phenomenon may occur rarely in colorectal @entity189 . Reduced membranous @entity5962 expression in the @entity189 central portion was significantly correlated with poor clinical outcome (P = .0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of @entity5962 in the central portion might be a good biomarker for an unfavorable prognosis in cases of @entity189 .
