Role of the microcirculation in the treatment and pathogenesis of XXXX .

@entity1 @entity455 @entity1569 @entity894 @entity1373 @entity1014
Controversy exists whether the initiating events in @entity1569 are primarily epidermal or dermal (vascular). To study this point, serial biopsies from 6 @entity1 were taken from the periphery of individual plaques before, and at 1 to 3 day intervals during, Goeckerman and PUVA treatments. Part of the biopsy was studied by electron microscopy to determine the fine structure of the capillary loops and part was incubated with tritiated @entity1014 to determine the @entity894 ( @entity894 ) of the basal cells. Normal appearing buttock skin of the 11 other psoriatic @entity1 not under treatment was studied by identical methods. In 4 of the 6 treated @entity1 , the capillary loops began to return toward normal 3 to 8 days before the @entity894 began to decrease. Two @entity1 did not show a return toward normal of either capillaries or @entity894 during the period of the experiment. The @entity894 was elevated in the normal appearing buttock skin of 6 of 11 untreated psoriatics. In 4 of the 6, the loops were normal arterial capillaries. We did not observe abnormal (venous) capillaries associated with a normal @entity894 in the other 5 untreated @entity1 . These data support the concept that the initiating factors in @entity1569 are in the epidermis, but @entity1373 cannot occur without @entity455 . Understanding the factors responsible for shortening the capillary loops during epidermal normalization and for inhibition of capillary growth in the presence of an increased @entity894 could lead to other ways of controlling @entity1569 .
