Detection of fungal organisms in eosinophilic mucin using a XXXX -labeled chitin-specific binding protein.

@entity1 @entity1711 @entity102 @entity1710 @entity941 @entity8776
BACKGROUND: The ability to identify fungal hyphae in @entity1 with @entity102 ( @entity102 ) has been inconsistent. A new @entity941 -labeled staining method targets chitin found in fungal cell walls. OBJECTIVE: We hypothesize that this method would be able to more consistently detect fungi within the mucin of @entity102 @entity1 . METHODS: Fifty-four consecutive @entity102 surgical @entity1 were evaluated. After ensuring sensitivity and specificity of this new method, all specimens were stained with either @entity941 -labeled chitinase or Grocott @entity8776 silver stain for comparison. RESULTS: All 54 specimens contained eosinophilic mucin on @entity1710 and @entity1711 staining. One or more fungal hyphae could be visualized within the mucin of 54 (100%) of 54 specimens stained using the @entity941 -labeled chitinase. Only 41 (76%) of 54 of the specimens stained with the Grocott @entity8776 silver stain technique demonstrated fungi. CONCLUSION: The @entity941 -labeled chitinase-staining technique has greater sensitivity in detecting fungal organisms within eosinophilic mucin. Fungal organisms are present in the mucin of @entity102 @entity1 .
