Results of the radiotherapeutic management of XXXX with emphasis on the influence of histologic classification.

@entity1 @entity4153 @entity957 @entity189 @entity152 @entity1962 @entity420
The histology of 365 of 396 @entity1 (92%) treated with radiation therapy at the University of Virginia from 1968 to 1978 has been reviewed. Staging and treatment policies were consistent throughout this period, and have enabled the influence of histologic classification on treatment results to be evaluated. @entity152 ( @entity152 ) was the most common type, 69%; followed by keratinizing (KSCC), 13%; and @entity420 , 6.6%. Other varieties included adenosquamous, 3.6%; small cell undifferentiated @entity189 , 2.7%; papillary squamous, 1.6%; and glassy cell, 1.4%. Overall survivals by stage were similar to those reported from other centers. When examined by histologic type, the 5-year survival rates ranged from 64% for adenosquamous to 13% for small cell. The most common varieties, @entity152 and KSCC, had survival rates of 61% and 40% (P = 0.008). Considering both stage and histologic type, the differences between @entity152 and KSCC persisted and were significant for Stage IIB (P = 0.023). Of particular interest are the poor results in @entity4153 and @entity420 , except in the earliest stages, and the good results for @entity1962 . The patterns of failure by histologic type showed that local failures were higher in cases of KSCC than in @entity152 , indicating a probable difference in radiosensitivity. Distant spread was similar for both types. Both @entity4153 and @entity420 showed high rates of distant spread and local failure except in the early stages. Considering survival and failure rates, three prognostic groups could be identified. In descending order of curability these were: 1) @entity152 and @entity1962 ; 2) KSCC, @entity957 , and @entity420 ; and 3) small cell @entity189 .
