Limaprost alfadex, a XXXX derivative, prevents deterioration of forced exercise capability in @entity35 with chronic compression of the spinal cord.

@entity2649 @entity602 @entity5015 @entity1745 @entity613 @entity35 @entity2636
STUDY DESIGN: Basic animal research. OBJECTIVE: Cervical spondylotic @entity602 is a common condition among elderly and often treated by surgery. To explore possibility of pharmacologic treatment, limaprost alfadex, a @entity5015 derivative with vasodilatory and antiplatelet action, was tried in a @entity35 chronic @entity1745 model. SUMMARY OF BACKGROUND DATA: Limaprost increased the blood flow of cauda equina and improved motor functions in animal models of @entity2649 . The drug is clinically used to treat neurogenic @entity613 . METHODS: : Forty-two @entity35 were allocated to four groups: (A) sham operation without permanent @entity1745 , given 5 mL/kg of distilled water twice a day (n = 6); (B) sham operation, receiving 300  g/kg limaprost twice a day (n = 6); (C) @entity1745 , receiving the vehicle (n = 15); and (D) @entity1745 receiving the drug (n = 15). A thin @entity2636 sheet that expands by absorbing water was implanted under the C5-C6 laminae to produce @entity1745 . For sham operation, the sheet was immediately removed. Exercise tests were repeated on a rotating treadmill until 26 weeks after surgery, and then the animals were killed and the spinal cord harvested for motor neurons counts. RESULTS.: Treadmill endurance (seconds, mean    standard error of mean) 2 weeks after surgery was 497.7    2.3, 434.5    65.5, 423.1    33.0, and 480.5    19.5 in groups A, B, C, and D, respectively. At 26th week, the duration was 497.7    2.3, 421.2    78.8, 21.3    11.7, and 441.3    40.4 (P < 0.0001 for the decrease in C group, multivariate analysis of variance with correction for multiple measures.) The motor neuron counts were 38.3    3.6, 38.2    2.6, 32.6    1.9, and 36.2    2.3 in groups A, B, C, and D (P = 0.34), respectively. CONCLUSION: Limaprost alfadex prevented decline of forced locomotion capability in @entity35 with chronic compression of the cervical cord.
