Hormone withdrawal-associated symptoms with @entity2082 20  g/ XXXX 3 mg (24/4 regimen) versus @entity2082 20  g/desogestrel 150  g (21/7 regimen).

@entity3347 @entity1 @entity2082 @entity4863 @entity2371 @entity7281 @entity46161 @entity10
OBJECTIVE: To assess whether the combined oral contraceptive (COC) @entity2082 ( @entity46161 ) 20  g/ @entity4863 3 mg taken in a 24/4-day regimen (ie, 4-day hormone-free interval) is more effective than an @entity46161 20  g/ @entity7281 (DSG) 150  g COC taken in a 21/7-day regimen (ie, 7-day hormone-free interval) in reducing @entity3347 ( @entity3347 ). METHODS: This double-blind, randomized study (NLM identifier: NCT01076582) was conducted at 34 centers in 12 countries. Otherwise healthy @entity1 who experienced >= 2 @entity3347 of @entity10 , @entity2371 , and/or bloating when using their current COCs in a 21/7-day regimen were recruited. Subjects rated the severity of their @entity3347 daily on a seven-point Likert scale during a baseline cycle and during four 28-day cycles with @entity46161 / @entity4863 24/4 (n=290) or @entity46161 /DSG 21/7 (n=304). The primary variable was the mean change from baseline to cycle 4 in the composite @entity3347 score (sum of scores for all three symptoms) during cycle days 22-28. RESULTS: In the @entity46161 / @entity4863 24/4 group, the mean (standard deviation) composite @entity3347 score during cycle days 22-28 was reduced from 42.2 (24.8) at baseline to 12.8 (13.4) at cycle 4 (change from baseline: -30.3 [22.9]). In the @entity46161 /DSG 21/7 group, the corresponding value was reduced from 41.9 (25.8) to 14.3 (13.2) (change from baseline: -27.7 [24.8]), not significantly different versus @entity46161 / @entity4863 24/4. Bleeding pattern, treatment response, rescue medication use, compliance, quality of life, and tolerability were similar between treatments. CONCLUSION: Both @entity46161 / @entity4863 24/4 and @entity46161 /DSG 21/7 reduced the composite @entity3347 score from baseline to cycle 4 in otherwise healthy @entity1 . The differences between treatments were too small to be statistically significant.
