Antibiotics and @entity500 for the treatment of perianal XXXX in @entity30 .

@entity1 @entity868 @entity66 @entity500 @entity2177 @entity292 @entity10227 @entity30
BACKGROUND: Antibiotics and @entity10227 have been employed in the management of fistulizing @entity30 , although evidence of their efficacy is rare. AIM: To evaluate, in a prospective, open-label study, the influence of antibiotics and @entity500 on the clinical outcome of perianal @entity292 in @entity1 with @entity30 . METHODS: Fifty-two @entity1 entered the study, starting with an 8-week regimen of @entity2177 (500-1000 mg/day) and/or @entity868 (1000-1500 mg/day). Seventeen @entity1 had already received daily @entity500 (2-2.5 mg/kg) at enrollment, whereas in 14 @entity1 @entity500 was initiated after 8 weeks of antibiotic treatment. Outcome was evaluated by Fistula Drainage Assessment and the @entity66 Activity Index at weeks 8 and 20. RESULTS: Overall, 26 @entity1 (50%) responded to antibiotic treatment, with complete healing in 25% of @entity1 at week 8. The @entity66 Activity Index decreased significantly from 8.4 +/- 2.9 to 6.0 +/- 4.0 (P < 0.0001). At week 20, the outcome was assessed in 49 @entity1 (94%), 29 of whom (59%) had received @entity500 . Response was noted in 17 of the 49 @entity1 (35%), with complete healing in nine @entity1 (18%). @entity1 who received @entity500 were more likely to achieve a response (48%) than those without immunosuppression (15%) (P = 0.03). The @entity66 Activity Index was closely associated with treatment response and perianal disease activity. CONCLUSION: Antibiotics are useful to induce a short-term response in perianal @entity30 , and may provide a bridging strategy to @entity500 , which seems to be essential for the maintenance of fistula improvement.
