Biological effects of diesel exhaust particles (DEP) on isolated cardiac muscle of XXXX .

@entity1169 @entity33150 @entity3933 @entity19 @entity4 @entity840 @entity1855 @entity3988 @entity3897 @entity18683 @entity3352 @entity1167 @entity224 @entity1370 @entity204
Diesel engine-powered vehicles emit some 30 to 100 times more particles than do @entity18683 engine cars. We previously reported that diesel exhaust particles (DEP) could produce @entity224 anions in an in vitro study. Furthermore, @entity19 instilled intratracheally with DEP showed high mortality at low doses. The cause of @entity204 was @entity4 with damage to the lung endothelial cells. In order to elucidate the mechanism of the onset of mortality induced by DEP, we examined the direct action of DEP on the isolated atrium of @entity840 . A light-duty (2740cc), four cylinder diesel engine was used. The DEP were collected on fiberglass filter. DEP caused a negative inotropic action that was followed by the @entity1167 of the isolated left atrium. These actions were not inhibited by @entity1169 , @entity3897 , @entity1855 , @entity3988 , @entity3933 , @entity3352 , @entity224 dismutase or @entity33150 . The precise mechanism of @entity1167 is unknown. However, these results suggest that @entity1370 induced by DEP might be involved in @entity4 .
