Abnormal serum XXXX levels are associated with clinical response to maximization of @entity712 therapy.

@entity1 @entity3747 @entity32 @entity712 @entity8 @entity2741 @entity7206 @entity460 @entity3151
INTRODUCTION: Abnormal serum @entity460 levels are associated with adverse cardiovascular effects. Therapy of @entity712 ( @entity712 ) may result in urinary @entity460 excretion and @entity460 apposition to bones, and consequently, in calcemia. OBJECTIVES: The aim of the study was to assess the prevalence of abnormal @entity460 levels in the blood of @entity1 receiving maximized @entity712 therapy, to explore clinical and laboratory determinants of abnormal serum @entity460 levels, and to analyze the relation of abnormal @entity460 levels to prognosis. @entity1 AND METHODS: The study included 722 @entity1 with @entity712 classified as New York Heart Association (NYHA) classes III-IV at baseline (age 53   10 years, 13% of @entity1 ), who underwent @entity712 therapy optimization to maximum tolerated doses. RESULTS: After therapy maximization, the NYHA class improved in 66.7% of the @entity1 , while it did not change in 31.0% and worsened in 2.4%. @entity3747 occurred in 166 @entity1 (22.9%) and was more prevalent in @entity1 in whom the NYHA class improved. @entity2741 was diagnosed in 63 @entity1 (8.7%) and was more common in @entity1 with no functional improvement or worsening of the NYHA class. This effect was independent of age, sex, etiology of @entity712 , body mass index, kidney function, or the use of @entity7206 . @entity2741 was associated with increased catabolism, hemodynamic compromise, more @entity32 , and lower bone mineral density. Lower albumin and higher @entity3151 levels, were significant predictors of @entity2741 , @entity8 . @entity3747 was associated with reduced catabolism, higher albumin and lower @entity3151 levels, use of @entity7206 , and smoking history. Neither @entity3747 nor @entity2741 was associated with poor prognosis. CONCLUSIONS: Our study shows that abnormal serum @entity460 levels are associated with a clinical response to treatment maximization in @entity1 with @entity712 . Mild @entity3747 after maximization of therapy is not associated with poorer prognosis. @entity2741 is associated with lack of response to treatment, and its prognostic value remains unclear.
