Evidence from pupillometry and fMRI indicates @entity158 but not physical @entity158 in XXXX .

@entity16282 @entity2438 @entity51 @entity72 @entity158
UNASSIGNED: @entity72 ( @entity72 ) is characterized by @entity51 . The notion that dysfunctions in neural circuits involved in sharing another's affect explain these deficits is appealing, but has received only modest experimental support. Here we evaluated a complex paradigm on the vicarious social @entity158 of embarrassment to probe social deficits in @entity72 as to whether it is more potent than paradigms currently in use. To do so we acquired pupillometry and fMRI in young adults with @entity72 and matched healthy controls. During a simple vicarious physical @entity158 task no differences emerged between groups in behavior, pupillometry, and neural activation of the anterior insula ( @entity16282 ) and anterior cingulate cortex (ACC). In contrast, processing complex vicarious social @entity158 yielded reduced responses in @entity72 on all physiological measures of sharing another's affect. The reduced activity within the @entity16282 was thereby explained by the severity of @entity2438 in the social and affective domain. Additionally, behavioral responses lacked correspondence with the anterior cingulate and anterior insula cortex activity found in controls. Instead, behavioral responses in @entity72 were associated with hippocampal activity. The observed dissociation echoes the clinical observations that deficits in @entity72 are most pronounced in complex social situations and simple tasks may not probe the dysfunctions in neural pathways involved in sharing affect. Our results are highly relevant because individuals with @entity72 may have preserved abilities to share another's physical @entity158 but still have problems with the vicarious representation of more complex emotions that matter in life. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.
