@entity209 and preclinical XXXX : focus on femoral arteries.

@entity1 @entity1674 @entity30147 @entity209 @entity731 @entity121 @entity65 @entity165
Several evidences revealed the relationship between the earliest stages of @entity731 and the components of @entity209 . The aim of this study was to disclose preclinical @entity731 in a cross-sectional observational study involving 147 @entity1 with @entity209 by the assessment of brachial flow-mediated vasodilation ( @entity30147 ) and intima-media thickening at both carotid and femoral sites. The purpose was to investigate the association of this @entity209 with prevalent @entity731 in different vascular sites. A control group of 87 healthy subjects was also investigated. @entity1 had lower values of @entity30147 and a higher mean @entity121 ( @entity121 ) at both the carotid and femoral sites with respect to controls. Flow-mediated vasodilation had a positive correlation with high-density lipoprotein (HDL) @entity165 and a negative one with low-density lipoprotein (LDL) @entity165 , glycemia, and insulinemia. Carotid mean @entity121 was directly related to LDL @entity165 and age, and inversely with HDL @entity165 ; femoral mean @entity121 had a direct association with LDL @entity165 , @entity1674 , glycemia, and insulinemia and an inverse correlation with HDL @entity165 and LDL size. LDL @entity165 , HDL @entity165 , insulin, and brachial artery diameter were predictive of brachial @entity30147 (beta=-0.17, 0.21, -0.27, and -0.29, respectively; P<.05), whereas age, LDL @entity165 , and HDL @entity165 were independent predictors of mean carotid @entity121 (beta=0.19, 0.37, and -0.27, respectively; P<.05); on the other hand, LDL @entity165 , @entity1674 , and insulin were independent predictors of mean femoral @entity121 (beta=0.32, 0.26, and 0.25, respectively; P<.05). In conclusion, the present study documented an altered endothelial function and intima-media thickening in @entity1 with @entity209 without overt @entity65 . Moreover, it focused on the strong influence of @entity209 on preclinical @entity731 at the femoral site.
