Development of a simplified single-apheresis approach for peripheral-blood progenitor-cell transplantation in previously treated XXXX with @entity706 .

@entity1 @entity1261 @entity706 @entity786 @entity2879 @entity2592 @entity3600 @entity3601 @entity1398 @entity2280
PURPOSE: The aims of this study were to develop a simplified, safe, and cost-effective peripheral-blood progenitor-cell (PBPC) mobilization protocol. @entity1 AND METHODS: Twenty-six @entity1 with relapsed or resistant @entity706 were entered onto a sequential cohort study in which schedules of various @entity1261 ( @entity1261 ) were administered after @entity786 1.5 g/m2. Hematologic recovery after high-dose @entity3600 ( @entity3600 ) @entity2879 , @entity2592 , and @entity3601 (BEAM) chemotherapy was compared with that of 46 @entity1 who received autologous bone marrow transplantation (ABMT) without growth factors and 28 @entity1 who received ABMT followed by @entity1261 . RESULTS: When @entity1261 (10 micrograms/kg/d) was administered from the day after the @entity786 , @entity1398 developed on day 8 followed by an abrupt increase in the WBC count. The optimal time for PBPC harvesting was the day on which the postnadir WBC count was greater than 8.0 x 10(9)/L, as shown by @entity2280 + cell counts and granulocytic-macrophage colony-forming cell (GM-CFC) assays. The reproducibility of the response was such that routine monitoring of @entity2280 + cell counts and GM-CFC was not necessary. A single leukapheresis on this day was adequate for prompt hematologic engraftment, and posttransplant @entity1261 made little further impact on the rapid recovery. Compared with both control groups, the use of PBPC led to more rapid neutrophil recovery, markedly accelerated platelet recovery, less use of antimicrobial agents and parenteral nutrition, and more than 10 days earlier discharge from hospital. All of these differences were highly significant (P < .01). CONCLUSION: A simplified mobilization protocol is described that requires only one apheresis to achieve rapid hematologic engraftment.
