Evolving resistant @entity2782 to @entity2177 in XXXX .

@entity1 @entity12088 @entity2782 @entity2177
OBJECTIVE: To determine whether there has been an increase in @entity2177 -resistant @entity2782 @entity12088 , and if this has increased the morbidity of the disease. STUDY DESIGN: Retrospective. SETTING: Tertiary referral center. @entity1 : Twenty-eight @entity1 over 13 years. RESULTS: The records of a total of 28 @entity1 who were admitted between 1988 and 2001 with the diagnosis of @entity12088 were reviewed. Seven @entity1 had @entity2177 -resistant @entity2782 on their hospital culture and sensitivity test. Five of the 7 resistant cases appeared in the last 3 years, as opposed to 2 of the 7 who appeared in the 10 years before that period. In our series, there is a significant trend developing over time of @entity2782 resistant to treatment with @entity2177 . No increased morbidity or mortality was found in the @entity2177 -resistant @entity2782 group compared with the remaining @entity1 who were sensitive to @entity2177 . CONCLUSIONS: In our series, resistance to @entity2177 in @entity1 with @entity12088 is increasing over time. This may have an impact on the relatively successful outpatient treatment of these @entity1 in the past decade. A return to inpatient or outpatient intravenous treatment with third-generation cephalosporins/antipseudomonal penicillins and more frequent debridement will be required in these @entity1 .
