Calbindin-d(28k): a marker of recurrence for XXXX .

@entity1 @entity5 @entity406 @entity876 @entity982 @entity141 @entity204 @entity2946
BACKGROUND: The expression of the @entity141 -binding protein calbindin-D(28k) was analyzed in @entity2946 in relation to clinical features and other biologic markers related to cell proliferation, differentiation, @entity876 , and cerebellar developmental regulated gene expression. METHODS: Immunohistochemistry was carried out on histologic slides from a first retrospective series of 29 nonmetastatic and 10 metastatic @entity2946 @entity406 -fixed, @entity982 -embedded tissues, using specific antibodies against calbindin-D(28k), calretinin, alpha-parvalbumin and beta-parvalbumin, and S100 proteins. Informed consent was obtained from the subjects and/or guardians. Other biologic markers for differentiation, cell proliferation, the expression of the @entity876 @entity5 suppressor gene protein, and cerebellar developmental regulated genes were similarly investigated. A second series of 16 @entity2946 from young @entity1 (younger than 15 years) was added in order to validate the results obtained in the first series. RESULTS: Of all the markers investigated, only calbindin-D(28k) was significantly associated with prognosis. Survival and remission (i.e. recurrence free) time analysis performed on all the cases (n = 55) confirmed a high risk of @entity204 (P = 0.004) and recurrence (P = 0.003) associated with calbindin-positivity. As calbindin-positivity was predominantly observed in @entity5 from young @entity1 , the authors confirmed its prognostic value in the subgroup of @entity1 younger than 15 years (n = 37). Cox regression analysis showed a significant and independent prognostic value for calbindin expression and, to a lesser extent, the type of surgery (total or subtotal). Three risk groups were thus identified, distinguishing among the cases characterized by a total resection and calbindin-negativity (good prognosis), by a subtotal resection and calbindin-negativity (intermediary), and by calbindin-positivity (bad prognosis). CONCLUSIONS: The current study suggests that @entity2946 represent a subclass of aggressive @entity5 more frequently seen in younger @entity1 .
