Sleep deprivation effects in older endogenous depressed XXXX .

@entity1 @entity1949 @entity25 @entity308
In a drug-free group of 15 older endogenous depressed inpatients, all-night @entity1949 ( @entity1949 ) was associated with a significant @entity308 scores and in Profile of Mood States self-ratings of @entity308 . Six of 15 @entity1 (40%) were responders to @entity1949 , as evidenced by greater than or equal to 30% improvement in Hamilton ratings. While symptomatic improvement was short-lived (8 of 15 @entity1 worsened after 1 night of @entity25 ), five @entity1 showed further improvement after 1 night of @entity25 . The final two @entity1 had an increase in Hamilton ratings after @entity1949 , with a return to baseline values after 1 night of @entity25 . Responders (but not nonresponders) showed significant improvement in sleep latency, sleep efficiency, and @entity25 during @entity25 (as did controls). The @entity1949 Hamilton @entity308 rating (at 9 a.m. after all-night @entity1949 ) showed a significant inverse correlation with the increase in @entity25 ( @entity25 ) minutes and in @entity25 % from baseline to first recovery night. Responders also had significantly larger increases in @entity25 minutes than did nonresponders (53.8 vs. 7 minutes). Similarly, the % change in Hamilton @entity308 ratings was predicted by baseline Stage 4 sleep. These findings suggest that there is a mutual interaction between the process of sleep regulation and the symptoms of @entity308 . They also confirm a prediction from the two-process model of sleep regulation--namely, that improved sleep initiation and maintenance and increased @entity25 , attained by @entity1949 , are associated with clinical improvement.
