[Prognostic factors in light chain XXXX ].

@entity1 @entity712 @entity2783 @entity1582 @entity12884
INTRODUCTION: Light chain @entity2783 is characterized by extracellular deposition of a fibrillar material derived from immunglobulin light chain fragments. AIM: The aim of the authors was to assess survival depending on cardiac involvement, therapy, and presence of @entity1582 . METHOD: The authors studied a retrospective cohort of 29 @entity1 with light chain @entity2783 (13 kappa, 16 lambda) treated in their institution between 2005 and 2014. RESULTS: Twenty-one @entity1 had @entity12884 , while 8 had coexisting multiple @entity1582 . One, two and three or more organs were involved in 4, 8, and 17 @entity1 , respectively. Cardiac involvement (22 cases) inversely correlated with survival. Fifteen (52%) @entity1 received chemotherapy only, while 14 (48%) underwent autologous stem cell transplantation with a median survival of 87 and 11.4 months, respectively. Two @entity1 had heart transplantation and survived 70 and 30 months. Median overall survival was 75.8 months. CONCLUSIONS: Cardiac transplantation followed by autologous stem cell transplantation is feasible in selected @entity1 with light chain @entity2783 and @entity712 .
