Small bowel motility affects @entity413 absorption in a healthy XXXX .

@entity4392 @entity1 @entity10546 @entity413 @entity46850
OBJECTIVE: To investigate the relationship between duodenojejunal motor activity and @entity413 absorption and to evaluate the effect of modification of duodenojejunal motility on @entity413 absorption by using the prokinetic drug @entity4392 . RESEARCH DESIGN AND METHODS: We examined seven healthy males, mean age 22 years, who were treated with @entity4392 10 mg t.i.d. and placebo during 3 days in a randomized order, with a 2-week time interval. Duodenojejunal manometry was performed after each treatment on the morning of day 3, using an 18-lumen catheter. A liquid nutrient (3 kcal/min) was administered intraduodenally for 30 min, followed by a bolus of the @entity413 analog @entity10546 ( @entity46850 ). Plasma @entity46850 concentrations were measured to assess absorption kinetics. RESULTS: The area under the @entity46850 concentration curve in the first 30 min after infusion was related to the number of antegrade propagated pressure waves (r = 0.49, P < 0.05), but not to the peak concentration, time to peak, and absorption fraction. The mean amplitude of pressure waves was higher during @entity4392 than placebo (P < 0.05), but the reoccurrence of interdigestive motility, numbers of pressure waves, and propagated pressure waves, as well as @entity46850 absorption characteristics, were not significantly different between the two treatments. During both treatments >60% of antegrade propagated pressure waves were propagated over a very short distance (1.5 cm). CONCLUSIONS: @entity413 absorption in the @entity1 small intestine is related to short-traveling propagated intestinal contractile activity. @entity4392 increases the amplitude of pressure waves, but does not affect the organization of pressure waves or the absorption of @entity46850 .
