Biochemical and histochemical changes pertaining to active and healed cutaneous XXXX .

@entity1 @entity82 @entity2362 @entity66 @entity219 @entity2533 @entity378
BACKGROUND: @entity82 is one of the major causes of post-treatment morbidity in @entity378 . The molecular basis of @entity82 in active and healed @entity66 is yet to be fully characterized. OBJECTIVES: To measure the tissue levels of collagen, @entity2362 , fibronectin, @entity2533 ( @entity2533 ) and @entity219 in active and healed lesions of cutaneous @entity378 . @entity1 AND METHODS: Biopsy lesions obtained from 17 @entity1 with active cutaneous @entity378 and 12 @entity1 after a 6-month regimen of antituberculous chemotherapy were examined. Collagen, @entity2362 and @entity219 were estimated biochemically. In addition, the presence of collagen IV, @entity2533 and fibronectin were determined immunohistochemically. RESULTS: It was found that collagen, @entity2362 , fibronectin and @entity2533 levels were higher in the active lesions. The levels of @entity219 were similar in both active and healed lesions. Clinically, scar tissue or keloid formation was not seen in any of the healed lesions. CONCLUSIONS: Effective antituberculous chemotherapy will lead to a substantial reduction of @entity82 and the consequent disability that can arise in @entity1 with @entity378 .
