Significance of low-dose and standard-dose ACTH tests compared to overnight XXXX test in the diagnosis of @entity1887 in childhood.

@entity1 @entity2338 @entity4235 @entity1887 @entity701 @entity7961 @entity774
OBJECTIVE: To discover the value of low-dose (LDAT) and standard-dose ACTH tests (SDAT) as compared with the @entity4235 test in the diagnosis of @entity1887 . @entity1 AND METHODS: LDAT (0.5 microg/m2), SDAT (250 microg/m2) and overnight @entity4235 (30 mg/kg) tests were carried out in 29 @entity1 with suspected @entity1887 . LDAT and SDAT were also performed in 36 control subjects. RESULTS: 18 of 29 @entity1 were grouped in the @entity774 ( @entity774 ) group and 11 of 29 @entity1 in the @entity774 ( @entity774 ) group according to the @entity4235 test results. The control group had significantly higher @entity701 responses than the @entity774 and @entity774 groups during LDAT. The control group had similar @entity701 responses to the @entity774 group but higher @entity701 responses than the @entity774 group during SDAT. The @entity774 group was divided into 2 subgroups: @entity774 @entity1 with multiple @entity7961 ( @entity774 -multiple) and @entity774 @entity1 with @entity2338 ( @entity774 -isolated). The @entity774 -multiple group had statistically lower @entity701 responses than the control group during LDAT. Receiver-operating characteristics analysis revealed that the @entity701 cutoff value in LDAT was 19.8 microg/dl (100% sensitivity, 89% specificity) and 30.4 microg/dl in SDAT (82% sensitivity, 78% specificity). CONCLUSION: LDAT is capable of identifying @entity1 with @entity1887 more effectively than SDAT. The @entity701 cutoff value in LDAT was calculated as 19.8 microg/dl with 100% sensitivity. @entity774 @entity1 with multiple @entity7961 had lower @entity701 responses to LDAT than the control group implying that these @entity1 might have a lower @entity701 secretory capacity than healthy subjects.
