Evolving Early Lung Cancers Detected During Follow-Up of XXXX : Serial CT Features.

@entity1 @entity16058 @entity5 @entity2 @entity358
OBJECTIVE: The purpose of this study was to evaluate the CT characteristics of newly developed @entity2 on CT studies obtained during follow-up of @entity16058 ( @entity16058 ) before the appearance of identifiable @entity5 to the time of @entity2 and thereafter. MATERIALS AND METHODS: The study sample included 66 @entity5 diagnosed in 63 @entity1 with @entity2 (59 @entity1 , four @entity1 ; median age, 64 years; range, 40-85 years) between October 1998 and July 2012. Two radiologists independently reviewed 193 CT scans, determined the earliest presence of @entity5 and @entity16058 , and evaluated @entity5 size, lobar and axial location, shape, and @entity5 density. Delay in clinical diagnosis and doubling time were measured with first and second follow-up CT examinations. RESULTS: Interobserver agreement was good (k > 0.77). The median @entity5 size was 17 mm (range, 5-30 mm) for the 46 T1a and 20 T1b @entity5 . Most of the @entity5 (42 [63.6%]) were located in the lower lobes. Thirty-five @entity5 (53.0%) were at the interface between fibrotic cyst and normal lung, and 21 (31.8%) were in the midst of fibrotic @entity358 . Most of the @entity5 had a round or oval shape (52 [78.8%]) and were solid (62 [93.9%]). The median delay in diagnosis was 46 days (range, 8-760 days). The first median doubling time was 77 days (range, 15-525 days), and the second was 53 days (27-248). CONCLUSION: New @entity2 during CT follow-up of @entity16058 usually appear as small solid nodules with a round or oval shape. Most @entity5 are located at the interface between fibrotic cyst and normal lung or in the midst of @entity358 .
