XXXX GENE POLYMORPHISM MODULATES THE RISK OF PERIODONTAL DISEASES.

@entity1 @entity650 @entity2520 @entity7278 @entity2522 @entity17894 @entity2521 @entity15147 @entity688
@entity2522 and @entity2521 are the two main @entity2520 . Both are characterized by inflammation of the tissues surrounding the teeth but while tissue damages observed in @entity2522 are mild and reversible, destruction caused by @entity2521 is deeper and irreversible. @entity2520 and levels of degeneration of tissues surrounding teeth depend on several interacting endogenous and exogenous factors. Polymorphisms of genes encoding molecules that modulate the immune response and tissue homeostasis are the main causes of individual susceptibility to @entity2520 . The aim of this study was to investigate @entity650 , @entity688 and @entity17894 gene polymorphisms in a large number of subjects affected by either @entity2522 or @entity7278 . The sample included 750 Italian @entity1 . We found that the @entity15147 SNP located in the @entity650 gene promoter was strongly associated with the occurrence of both @entity2522 and @entity2521 . Indeed, homozygous individuals with variant allele appeared less-susceptible to both @entity2522 OR=0.47 (95% C.I. 0.27-0.82) and @entity2521 OR=0.36 (95% C.I. 0.21-0.64). No evidence of association between @entity2520 and @entity688 or @entity17894 polymorphisms was obtained. This data confirmed the role of @entity650 in susceptibility to @entity2521 among the Italian population. The evidence that @entity650 polymorphisms are also involved in @entity2522 has implications in periodontal disease pathogenesis and reduces the appeal of @entity650 as a @entity2521 biomarker.
