The Analgesic Effect of @entity7428 , a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced @entity9 in XXXX .

@entity1931 @entity7428 @entity1311 @entity1919 @entity158 @entity35 @entity9 @entity16180
BACKGROUND: Chemotherapy-induced @entity9 is a significant side effect of chemotherapeutic agents. Currently, there are no effective analgesics for chemotherapy-induced @entity9 . @entity7428 is a selective phosphodiesterase 4 inhibitor, which increases intracellular @entity1919 in nerve and immune cells. The aim of our study was to determine the analgesic effects of @entity7428 on @entity1311 ( @entity16180 )-induced @entity9 in @entity35 . METHODS: Chemotherapy-induced @entity9 was produced by intraperitoneal injection of @entity16180 on 4 alternate days in male @entity35 . Mechanical @entity1931 was measured by using von Frey filaments. RESULTS: After the @entity35 developed @entity16180 -induced @entity158 behavior (such as @entity1931 ), a single intraperitoneal injection and continuous infusion of @entity7428 ameliorated @entity16180 -induced @entity158 behavior. In addition, systemic infusion of the drug during the early phase of developing @entity158 behavior did not prevent the development of @entity1931 induced by @entity16180 . CONCLUSIONS: These results suggest that @entity7428 alleviated @entity1931 induced by @entity16180 in @entity35 . Thus, phosphodiesterase 4 inhibitors may prove useful in the treatment of chemotherapy-induced @entity9 . However, further studies are needed to clarify their effects in clinical settings.
