Preventive effect of an antiallergic drug, pemirolast potassium, on XXXX after stent placement: quantitative coronary angiography and intravascular ultrasound studies.

@entity1 @entity1373 @entity14309 @entity256
OBJECTIVES: The preventive effect of pemirolast against @entity256 after coronary stent placement was evaluated. METHODS: Eighty-four @entity1 with 89 de novo lesions who underwent successful coronary stenting were assigned to the pemirolast group(40 @entity1 , 45 lesions) and the control group(44 @entity1 , 44 lesions). Administration of pemirolast(20 mg/day) was initiated from the next morning after stenting and continued for 6 months of follow-up. Quantitative coronary angiography was performed immediately after stenting and at follow-up. @entity256 was defined as diameter stenosis > or = 50% at follow-up. Intravascular ultrasound study conducted at follow-up angiography was used to measure vessel cross-sectional area(CSA), stent CSA, lumen CSA, @entity14309 (stent CSA--lumen CSA), and percentage @entity14309 ( @entity14309 /stent CSA x 100%) at the minimal lumen site. RESULTS: There were no significant differences in baseline characteristics between the two groups. @entity256 rate was significantly lower in the pemirolast group than in the control group(15.0% vs 34.1% of @entity1 , 13.3% vs 34.1% of lesions, p < 0.05, respectively). The intravascular ultrasound study at follow-up(36 lesions in the pemirolast group, 33 in the control group) found no significant differences in vessel CSA and stent CSA between the two groups(17.3 +/- 2.2 vs 16.8 +/- 2.4 mm2, 8.6 +/- 1.9 vs 8.4 +/- 1.7 mm2, respectively). However, lumen CSA was significantly larger in the pemirolast group than in the control group(5.5 +/- 1.3 vs 4.4 +/- 1.1 mm2, p < 0.05). Moreover, @entity14309 and percentage @entity14309 were significantly smaller in the pemirolast group(3.1 +/- 1.1 vs 4.0 +/- 1.2 mm2, p < 0.05 and 36.2 +/- 15.9% vs 47.4 +/- 15.6%, p < 0.01). CONCLUSIONS: Pemirolast has a preventive effect against @entity256 after stent placement, possibly by inhibiting neointimal @entity1373 .
