Continuous monitoring of circadian glycemic patterns in XXXX receiving @entity617 for @entity1030 .

@entity1 @entity6 @entity699 @entity1030 @entity4854 @entity413 @entity617
CONTEXT: Endogenous glucocorticoid excess ( @entity699 ) predominantly increases postprandial @entity413 concentration. The pattern of @entity4854 induced by @entity617 has not been well characterized. OBJECTIVE: Our objective was to define the circadian effect of @entity617 on @entity413 concentration to optimize management of @entity617 -induced @entity4854 . DESIGN AND SETTING: This was a cross-sectional study in a teaching hospital. @entity1 : @entity1 included 60 consecutive consenting subjects with @entity1030 admitted to hospital: 13 without known @entity6 admitted for other indications and not treated with glucocorticoids (group 1), 40 without known @entity6 admitted with an exacerbation of @entity1030 and treated with @entity617 (group 2, @entity617 = 30    6 mg/d), and seven with known @entity6 treated with @entity617 (group 3, @entity617 = 26    9 mg/d). MAIN OUTCOME MEASURE: Interstitial @entity413 concentration was assessed during continuous @entity413 monitoring. RESULTS: Significantly more subjects in group 2 [21 of 40 (53%), P = 0.02] and group 3 [seven of seven (100%), P = 0.003] recorded a @entity413 of at least 200 mg/dl (>= 11.1 mmol/liter) during continuous @entity413 monitoring than in group 1 [one of 13 (8%)]. The mean @entity413 concentration between 2400-1200 h for group 3 (142    36 mg/dl) was significantly greater than in the other two groups (P < 0.005), whereas mean @entity413 concentrations between 2400-1200 h in group 1 (108    16 mg/dl) and group 2 (112    22 mg/dl) were not significantly different. In contrast, the mean @entity413 concentrations between 1200-2400 h for group 2 (142    25 mg/dl) and group 3 (189    32 mg/dl) were both significantly greater than group 1 (117    14 mg/dl, P < 0.05 for both comparisons). CONCLUSIONS: @entity617 predominantly causes @entity4854 in the afternoon and evening. Treatment of @entity617 -induced @entity4854 should be targeted at this time period.
