Association of tumor XXXX factor polymorphisms with @entity565 and serum total IgE.

@entity1 @entity39 @entity310 @entity565 @entity15646 @entity4909
Tumor @entity39 factors ( @entity4909 ; @entity310 and @entity4909 ) are major pro-inflammatory cytokines that are thought to be important in the pathogenesis of @entity565 . However, the functions of genetic polymorphisms in these cytokines have not been thoroughly examined in the context of @entity565 pathology. In an effort to discover polymorphism(s) in genes whose variant(s) have been implicated in @entity565 phenotypes, we examined the genetic effects of @entity4909 ( @entity310 and @entity4909 ) polymorphisms on @entity565 and total serum IgE level. Seven common single-nucleotide polymorphisms (SNP) in @entity4909 genes were genotyped in a Korean @entity565 cohort (asthmatics n=550, normal controls n=171). Six common haplotypes could be constructed in the @entity4909 gene cluster due to very strong LD between @entity310 and @entity4909 , located 13 kb apart on chromosome 6p21. One SNP ( @entity310 @entity15646 ) showed a significant association with the risk of @entity565 (P=0.0004). The frequency of @entity310 -308A allele-containing genotype in asthmatics (9.8%) was much lower than that in normal controls (22.9%). The protective effects of this polymorphism on @entity565 were also evident in separated subgroups by atopic status (P=0.05 in non-atopic subjects and P=0.003 in atopic subjects). The most common haplotype of the @entity4909 gene ( @entity4909 -ht1[GGTCCGG]) was associated with total serum IgE (immunoglobulin E) levels in @entity565 @entity1 , especially in non-atopic @entity1 (P=0.004). Genetic variants of @entity4909 might be involved in development of @entity565 and total serum IgE level in @entity565 @entity1 . The results of this study could be helpful to understand the function of important @entity4909 genes in @entity565 and IgE production.
