Clinical Risk Factors for In-hospital Adverse Cardiovascular Events After Acute Drug XXXX .

@entity1 @entity1032 @entity296 @entity3157 @entity299 @entity1167 @entity1162 @entity943 @entity1445
OBJECTIVES: It was recently demonstrated that adverse cardiovascular events (ACVE) complicate a high proportion of hospitalizations for @entity1 with acute drug @entity1445 . The aim of this study was to derive independent clinical risk factors for ACVE in @entity1 with acute drug @entity1445 . METHODS: This prospective cohort study was conducted over 3 years at two urban university hospitals. @entity1 were adults with acute drug @entity1445 enrolled from the ED. In-hospital ACVE was defined as any of @entity296 , shock, @entity943 , or @entity1167 . RESULTS: There were 1,562 @entity1 meeting inclusion/exclusion criteria (mean age, 41.8 years; female, 46%; suicidal, 38%). ACVE occurred in 82 (5.7%) @entity1 ( @entity296 , 61; shock, 37; @entity943 , 23; cardiac arrests, 22) and there were 18 (1.2%) deaths. On univariate analysis, ACVE risk increased with age, lower serum @entity3157 , @entity1162 , prior @entity299 , and @entity1032 . In a multivariable model adjusting for these factors as well as @entity1 sex and hospital site, independent predictors were: QTc > 500 msec (3.8% prevalence, odds ratio [OR]  = 27.6), @entity3157 < 20 mEq/L (5.4% prevalence, OR  = 4.4), and prior @entity299 (7.1% prevalence, OR  = 9.5). The derived prediction rule had 51.6% sensitivity, 93.7% specificity, and 97.1% negative predictive value, while presence of two or more risk factors had 90.9% positive predictive value. CONCLUSIONS: The authors derived independent clinical risk factors for ACVE in @entity1 with @entity1445 , which should be validated in future studies as a prediction rule in distinct @entity1 populations and clinical settings.
