Dietary fibre intake and risk of ischaemic and XXXX in the UK @entity1 's Cohort Study.

@entity1 @entity64 @entity101 @entity548
Background: @entity64 risk is modifiable through many risk factors, one being healthy dietary habits. Fibre intake was associated with a reduced @entity64 risk in recent meta-analyses; however, data were contributed by relatively few studies, and few examined different @entity64 types.Methods:A total of 27   373 disease-free @entity1 were followed up for 14.4 years. Diet was assessed with a 217-item food frequency questionnaire and @entity64 cases were identified using English Hospital Episode Statistics and mortality records. Survival analysis was applied to assess the risk of total, ischaemic or @entity548 in relation to fibre intake.Results:A total of 135 @entity548 and 184 @entity64 cases were identified in addition to 138 cases where the @entity64 type was unknown or not recorded. Greater intake of total fibre, higher fibre density and greater soluble fibre, insoluble fibre and fibre from cereals were associated with a significantly lower risk for total @entity64 . For total @entity64 , the hazard ratio per 6   g/day total fibre intake was 0.89 (95% confidence intervals: 0.81-0.99). Different findings were observed for @entity548 and @entity64 in healthy-weight or overweight @entity1 . Total fibre, insoluble fibre and cereal fibre were inversely associated with @entity548 risk in overweight/obese @entity1 , and in healthy-weight @entity1 greater cereal fibre was associated with a lower @entity64 risk. In non- @entity101 @entity1 , higher fibre density was associated with lower @entity64 risk.Conclusions:Greater total fibre and fibre from cereals are associated with a lower @entity64 risk, and associations were more consistent with @entity64 . The different observations by @entity64 type, body mass index group or @entity101 status indicates potentially different mechanisms.European Journal of Clinical Nutrition advance online publication, 3 December 2014; doi:10.1038/ejcn.2014.260.
