Development, worsening, and improvement of diabetic microangiopathy in older @entity1 : six-year prospective study of XXXX under intensive @entity6 control.

@entity1 @entity8 @entity64 @entity455 @entity101 @entity6 @entity1007 @entity5 @entity989 @entity1011 @entity4854 @entity165
OBJECTIVES: To examine @entity989 and @entity8 in elderly @entity1 with @entity6 ( @entity6 ) under intensive multifactorial @entity6 control. DESIGN: Six-year interventional observation study. SETTING: Multicenter study including four hospitals. @entity1 : Four hundred thirteen elderly (> or = 65) @entity1 with type 2 @entity6 attending each hospital for 1 year or longer; those receiving hemodialysis or with uncured @entity5 were excluded. MEASUREMENTS: Development, worsening, and improvement of @entity989 and @entity8 and respective risk factors. RESULTS: The mean baseline hemoglobin (HbA1c), blood pressure (BP), and total @entity165 were 6.8%, 137/74 mmHg, and 5.13 mmol/L, respectively. @entity989 developed in 45 of 168 (27%) @entity1 and, of 63 with @entity989 , worsened and improved in 11 (17%) and 23 (37%), respectively. @entity8 developed in 53 of 227 (23%) @entity1 and improved in 13 of 51 (25%) having it baseline. The mean change in glomerular filtration rate (DeltaGFR, baseline GFR-GFR at the end of the study period) in those with @entity8 at baseline was 21.5 mL/min. HbA1c was related to development of @entity989 (P=.001, odds ratio (OR)=1.91), and serum @entity1011 (P=.03, OR=1.02), systolic BP (SBP) (P=.03, OR=1.22), and prior @entity64 (P=.005, OR=3.21) were related to development of @entity8 . In @entity1 with @entity8 at baseline, SBP (P=.03, Spearman's rho (rho)=0.310), total @entity165 (P=.01, rho=0.361), and low-density lipoprotein @entity165 (P=.03, rho=0.322) were correlated with DeltaGFR. CONCLUSION: In elderly @entity1 under intensive control for @entity6 , the outcome of @entity455 is favorable. Modifiable risk factors were @entity4854 for development of @entity989 and @entity101 and @entity1007 for development or worsening of @entity8 ; prior @entity64 was an unmodifiable risk factor for development of @entity8 .
