Increased vascular injury reduces the degree of XXXX following angioplasty in @entity95 .

@entity1603 @entity1373 @entity95 @entity13214 @entity731 @entity393 @entity130 @entity8233
BACKGROUND/AIMS: Formation of @entity1373 following angioplastic procedures can lead to complications, including restenosis and accelerated @entity731 . The vessel wall media is a main source of neointimal cells. However, evidence suggests that there are additional cell sources, such as the adventitia. Here we investigate whether an extensive loss of vascular smooth muscle cells (VSMCs) in the media results in less @entity1373 or if there is compensatory cell recruitment from the adventitia. METHODS: A balloon catheter was pulled through the @entity95 carotid artery 4 times ( @entity130 ) or 2 times ( @entity130 ). Adventitial cells were labeled with @entity1603 or @entity13214 . RESULTS: The @entity130 , but not the @entity130 , resulted in a complete loss of VSMCs in large parts of the media and significant leukocyte infiltration. The @entity130 resulted in less @entity8233 compared with the @entity130 . The thinnest @entity8233 was seen at the most injured parts of the media in the @entity130 group. Cell-tracking experiments showed that the media, but not the adventitia, served as a source of neointimal cells. CONCLUSION: An augmented @entity130 with extensive @entity393 in @entity95 reduced the degree of @entity1373 . No compensatory recruitment of neointimal cells from the adventitia occurred.
