High-grade culprit lesions are a common cause of XXXX .

@entity1 @entity731 @entity384 @entity583
INTRODUCTION: Conventional knowledge holds that the majority of @entity731 causing @entity583 ( @entity583 ) are found in moderate stenoses that produce < 50% loss of arterial diameter. This study aimed to analyse the culprit lesions in @entity1 who presented with @entity583 and underwent primary percutaneous coronary intervention (PPCI) at our institution. METHODS: @entity1 who underwent PPCI between June 2008 and August 2010 at our institution were included in the analysis. Quantitative coronary angiography was performed for the culprit lesions immediately after antegrade flow was restored by thrombectomy, low-profile balloon predilatation or guidewire crossing. RESULTS: A total of 1,021 @entity1 were included in the study. The mean age was 57    12 years and 85.2% were male. Lesion measurement was done after coronary flow was restored by thrombectomy (73.1%), @entity384 (24.1%) and following guidewire passage across the lesion (2.8%). Mean minimal luminal diameter was 1.1    0.5 mm, mean reference vessel diameter was 2.8    0.6 mm, mean diameter stenosis was 61    16% and mean lesion length was 16    6 mm. Most (80.2%) of the culprit lesions had diameter stenoses > 50% (p < 0.01). Although balloon angioplasty was performed in 24.1% of the @entity1 , the majority (64.2%) still had diameter stenoses > 50%. High-grade stenoses (> 50%) were more frequently observed in male @entity1 (p = 0.04). CONCLUSION: Contrary to the existing paradigm, we found that most of the @entity1 with @entity583 in our institution had culprit lesions with diameter stenosis > 50%.
