Systemic effects of dietary n-3 @entity5204 supplementation accompany changes of CNS parameters in XXXX .

@entity5204 @entity1474 @entity2819 @entity35 @entity1779 @entity71003
Dietary supplementation with long-chain @entity1474 ( @entity5204 ) has become an attractive possibility to alleviate or prevent cerebrovascular pathophysiology. To characterize the potentially beneficial cerebrovascular action of n-3 @entity5204 that predominantly occur in fish oil, we set up an experimental paradigm where @entity35 with chronic @entity1779 were supplied with n-3 @entity5204 -enriched diets. @entity1779 was created by a permanent, bilateral occlusion of the common carotid arteries (2VO) of @entity35 at the age of 4 months, with a survival of 3 months. Simultaneously, the @entity35 were provided with experimental diets from the time of weaning until the termination of the experiments. The control diet was comparable to standard @entity35 chow, while @entity71003 contained additional n-3 @entity5204 and diet 2 was further enriched with structural phospholipids and neurotransmitter precursors. In summary, the data show that diet 2 improved spatial learning of 2VO @entity35 in the Morris water maze. Both @entity71003 and diet 2 augmented blood-brain barrier parameters and increased the density of the M1-type muscarinic cholinergic receptors in the hippocampus independent of the rate of cerebral perfusion. In addition to an overview of these results, changes that were supportive or accompanying those described in the CNS are also presented. Briefly, plasma @entity2819 concentration was elevated most explicitly by 2VO, while the relative weight of the liver and spleen increased due to the diets. The data draw attention to changes not only in the CNS, but also in the periphery as a consequence of chronic supplementation with n-3 @entity5204 -enriched diets.
