Radioimmunodetection of XXXX .

@entity1 @entity5493 @entity5 @entity787 @entity14 @entity694
This study examines the accuracy of @entity14 radioimmunodetection. Twenty-seven @entity1 with a history of histologically-confirmed @entity694 received a high-titer, purified goat anti- @entity787 IgG labelled with 131-I at a total dose of at least 1.0 muCi. Various body views were scanned at 24 and 48 hours after administration of the radioantibody. Three additional cases were evaluated; one had a @entity5493 in the rectum and received the 131-I-labelled anti- @entity787 IgG, while two @entity694 @entity1 received normal goat IgG labelled with 131-I. All of the 7 cases with primary @entity14 showed true-positive @entity5 localization, while 20 of 25 sites of metastatic @entity14 detected by immune scintigraphy were corroborated by other detection measures. The sensitivity of the radioimmunodetection of @entity14 (primary and metastatic) was found to be 90% (true-positive rate), the putative specificity (true-negative rate) was 94%, and the appraent overall accuracy of the technique was 93%. Neither the case of a @entity5493 receiving the anti- @entity787 IgG nor the two cases of @entity694 receiving normal goat IgG showed @entity5 radiolocalization. Very high circulating @entity787 titers did not appear to hinder successful @entity5 radiolocalization. These findings suggest that in @entity14 the method of @entity787 radioimmunodetection may be of value in preoperatively determining the location and extent of disease, in assessing possible recurrence or spread postoperatively, and in localizing the source of @entity787 production in @entity1 with rising or elevated @entity787 titers. An ancilliary benefit could be a more @entity5 -specific detection test for confirming the findings of other, more conventional diagnostic measures.
