[Development of a XXXX experimental model oriented at training. Application in the training of depuration techniques in the management of severe sepsis].

@entity326 @entity235 @entity1457 @entity515 @entity526
OBJECTIVE: To define a @entity326 experimental model that can be used in for training in the early management of @entity326 , specifically by extracorporeal depuration (ECD). DESIGN: A case-control experimental study. SETTING: Veterinary university hospital. SUBJECTS: Ten @entity235 (weight 12-15kg). INTERVENTIONS: Shock was induced using 1mg/kg @entity526 lipopolysaccharide (LPS) diluted in 20 mL saline infused in 10 minutes, with a subsequent follow-up at 6 hours. There was no intervention in 5 animals in order to define the natural course of the @entity1457 and 5 underwent high volume hemofiltration (HVHF, 100mL/kg/h) to define delay in response to treatment. VARIABLES: Pressures (arterial and pulmonary), hemodynamic parameters, gastric tonometry and respiratory function were recorded. RESULTS: The LPS effect was evidenced at 2 minutes of the infusion and the 10 animals showed severe @entity1457 at the end of the infusion. At 2-hours, changes between treated and non-treated animals were seen in cardiac output, systolic volume variability and mucous @entity515 . Mean arterial pressure was significantly different at four hours. All non-treated subjects died during the 6-hour follow-up and all the treated animals survived for this period. Based on these results, we developed a workshop that has been used in five courses (www.ccmijesususon.com - www.crrtcordoba.com.es/), obtaining the previous results. CONCLUSIONS: Our @entity1457 model shows a predictable behavior, very short latency and a sufficiently rapid improvement in the treated animals for it to be applied in training workshops. It is useful for training in the high-volume hemofiltration (HVHF) and can be used for training in the early management of @entity326 .
