Effect of Alnus japonica extract on a model of XXXX in NC/Nga @entity19 .

@entity32 @entity483 @entity10178 @entity59 @entity548 @entity19 @entity988 @entity294 @entity61 @entity9586 @entity56 @entity13633 @entity58 @entity272 @entity195 @entity1312 @entity484
AIM OF THE STUDY: The bark of Alnus species has long been used in traditional oriental medicine in the treatment of many pathological conditions, including fever, @entity548 , @entity294 , @entity988 , various @entity272 (e.g. chronic herpes, @entity484 and @entity9586 ), and @entity32 . In order to assess the immunomodulatory efficacy of a novel herbal medicine in treating @entity483 , we measured serum levels of several @entity56 and inflammatory biomarkers in NC/Nga @entity19 before and after treatment with this experimental agent. MATERIALS AND METHODS: Gene and protein expression analyses of @entity13633 and @entity10178 were quantified by real time PCR and Western blot analysis and serum levels of @entity58 were also measured by ELISA, all of which were reduced after treatment with the experimental agent. Additionally, serum concentrations of IgE and blood eosinophil counts were reduced in treated @entity19 . RESULTS: The topical application of leaf and bark extract from Alnus japonica suppressed the development of @entity195 -like @entity272 . The percent of blood eosinophils was decreased after treatment with leaf and bark extract from Alnus japonica. The serum IgE and @entity61 -related cytokine levels were decreased after treatment with leaf and bark extract from Alnus japonica compared with those treated with base cream (vehicle treated @entity195 group). The @entity58 , @entity59 and @entity1312 were lower than those of vehicle treated @entity195 group. CONCLUSIONS: We contend that leaf and bark extract from Alnus japonica may prove useful in the treatment of @entity483 and other @entity56 @entity272 , although more in-depth clinical studies are necessary before clinical implementation.
