Parametric perfusion imaging with contrast-enhanced ultrasound in acute XXXX .

@entity1 @entity64 @entity2500 @entity1188 @entity385
BACKGROUND AND PURPOSE: Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data after ultrasound contrast agent bolus injection to analyze brain tissue perfusion. First reports indicate that this method can display cerebral perfusion deficits in acute @entity385 . We performed a prospective @entity1 study to evaluate this approach. METHODS: Thirty consecutive @entity1 suffering from @entity2500 who presented to our department within 12 hours after symptom onset were investigated with ultrasound perfusion harmonic imaging (PHI) after Levovist bolus injection. Color-coded perfusion maps were calculated from the ultrasound data. In addition, the original gray-scale images were analyzed in cine mode. Findings were compared with those of cranial CT. RESULTS: All 30 @entity1 suffered from acute @entity385 of the middle cerebral artery territory (median National Institutes of Health @entity64 Scale score, 16 points). Twenty-three of the 30 @entity1 (76.7%) had sufficient PHI insonation conditions. In 19 of these 23 @entity1 (82.6%), a marked deficit in contrast enhancement could be visualized by initial PHI with the color-coded parameter images and cine-mode images. In 17 of the 23 (73.9%), the perfusion deficit was found on the parameter images. The area of hypoperfusion in the initial PHI investigation corresponded to the definite area of @entity1188 in follow-up cranial CT. In 3 of 23 @entity1 (13.0%), a perfusion deficit could be demonstrated in PHI, although the supplying artery was found patent by transcranial color-coded duplex sonography. CONCLUSIONS: With PHI, it is possible to display cerebral perfusion deficits in acute @entity385 . PHI yields additional information on the perfusion state of the @entity1 brain compared with extracranial and transcranial color-coded duplex sonography.
