The relationship between infratentorial lesions, balance deficit and @entity2332 in XXXX .

@entity1 @entity2194 @entity76 @entity74 @entity15 @entity2332
OBJECTIVE: The role of static posturography and magnetic resonance imaging (MRI) in identifying @entity1 at high risk of falls was investigated. Relationships between static posturography measures and MRI metrics were also investigated. METHODS: A total of 31 ambulatory @entity15 @entity1 (EDSS ranging from 2.0 to 5.0) with a @entity74 were recruited. Each @entity1 underwent a static posturography with a monoaxial platform and a conventional 1.5 T brain MRI scan. Measurements of T1-hypointense and T2-hyperintense lesion volumes (LVs), focusing on lesions selectively located at infratentorial levels, were performed by two operators unaware of clinical data. The self-reported number of falls in the previous 6 months was considered as the main outcome measure. RESULTS: Fourteen (45%) @entity1 reported 1 or more falls over the past 6 months. When compared to non-faller @entity1 , they had a higher EDSS score, poorer static standing balance, and greater brainstem and @entity76 ( @entity76 ) T2-LVs. A strength correlation between brainstem T2-LV and impaired static standing balance in an @entity2194 was also found. In the multivariate analysis, the variables more strictly associated with recurrent falls were greater T2-LV at the @entity76 (beta: 6.2; p=0.01) and brainstem (beta: 5.8; p=0.001) levels, and a wider displacement of the body center of pressure in the @entity2194 (beta: 0.02; p=0.03). CONCLUSION: Our data suggests that the damage of specific infratentorial areas negatively affect the static standing balance and may predispose @entity15 @entity1 to @entity2332 . These findings might contribute in selecting @entity1 requiring a proper rehabilitation intervention program.
