Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular XXXX , and @entity726 eyes.

@entity227 @entity455 @entity1538 @entity101 @entity726 @entity15534 @entity989
PURPOSE: Disturbed peripapillary microcirculation may have a role in the development of @entity726 . Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in @entity726 . In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and @entity15534 ( @entity15534 , % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular @entity101 (OHT), and primary @entity1538 eyes. CASE REPORT: The AngioVue OCT and the 2015.100.0.33 software version was used for @entity15534 measurements. The @entity15534 in the radial peripapillary capillary layer was similar (approximately 60%) in all 3 sectors in healthy eyes. In @entity726 with severe ST and/or IT RNFL defect, @entity15534 declined to 32%-45% in the damaged sectors but remained above 55% in the T sector. In the OHT eyes with no @entity227 and no RNFL sector outside the normal limits but with mild ST or IT RNFL damage, @entity15534 declined to 54% in the involved sector in all cases, while it remained around 60% in the other sectors. CONCLUSIONS: Our cases suggest that PADF measurements can identify decreased peripapillary perfusion early in the @entity989 thinning process, prior to the development of clinically significant RNFL @entity227 . Decreased @entity15534 corresponds spatially with the damaged RNFL bundles. The results suggest that prospective studies using @entity15534 may help to understand the role of @entity455 in @entity726 .
