Influence of XXXX on eating in @entity28 @entity1 .

@entity1 @entity28 @entity935 @entity448 @entity2727
OBJECTIVE: Rapid synaptic @entity935 transport or reduced brain @entity935 receptor signaling may influence energy intake. @entity2727 , a @entity935 reuptake inhibitor, increases brain synaptic @entity935 and produces @entity448 , suggesting that it may reduce energy intake. We investigated the effects of two doses of short-acting @entity2727 on energy intake over one meal in @entity28 adult males. RESEARCH METHODS AND PROCEDURES: Nine @entity28 males (>85th BMI percentile) ingested a placebo or a moderate dose (0.5 mg/kg) or a high dose (1.0 mg/kg) of @entity2727 in a within-subject double-blind acute laboratory study. One hour after ingestion, pizza consumption was measured in a naturalistic laboratory setting. RESULTS: @entity1 reduced energy intake by 23% for the moderate dose vs. the placebo (p < 0.02), but there was no significant difference for the high dose vs. the moderate dose (p > 0.05). @entity1 consumed 34% fewer kilocalories after ingesting the lowest effective dose of @entity2727 compared with placebo (725.7 +/- 404.5 vs.1095 +/- 271.1 kcal, p < 0.01). Seven of nine subjects responded to the moderate dose. The increase in perceived drug effect above placebo was correlated with the reduction in energy intake for both the moderate (r = -0.85, p = 0.004) and the high (r = -0.75 p = 0.021) doses. Hunger scores were not different across drug doses or placebo before drug administration. DISCUSSION: @entity2727 reduced energy intake of a highly palatable food over one meal by one-third in @entity28 adult males. @entity935 transport inhibition may be an effective component of a comprehensive treatment for @entity28 .
