Lymphocytic infiltration and expression of @entity1590 in photochemically induced @entity63 of the XXXX cortex.

@entity64 @entity18895 @entity2806 @entity63 @entity1188 @entity35 @entity1590
The contribution of the immune system to the pathogenesis of @entity2806 is still uncertain. We have analyzed leukocyte infiltration in photochemically induced focal @entity63 of the @entity35 parietal cortex by immunocytochemistry. Between 1 and 2 days after photothrombosis, @entity18895 + T cells adhered to subpial and cortical vessels and infiltrated the @entity2806 prior to macrophages. By day 3 numerous T cells and some macrophages, whose number increased further between day 3 and day 7, had infiltrated the border zone around the lesion sparing the center. In addition, @entity18895 -/CD8+ lymphocytes that probably represent natural killer cells were found. @entity1590 ( @entity1590 ) was expressed on endothelial cells on days 1 and 2 and in the border zone on infiltrating leukocytes from day 3 to day 7. Starting on day 7, macrophages infiltrated the core of the lesion to remove debris. When the entire lesion was covered by macrophages at day 14, the number of T cells had decreased and @entity1590 immunoreactivity was no longer found in or around the @entity1188 . In conclusion, our study shows that @entity2806 can lead to a local immune reaction in the CNS. Thus, blocking of lymphocyte-derived cytokines or cell adhesion molecules may provide a new approach to confining the sequelae of @entity64 .
