XXXX : metastatic patterns and their prognosis.

@entity1 @entity0 @entity75 @entity79 @entity3
From 1969 to 1977, @entity3 developed in 145 of the 558 @entity1 treated for @entity0 at the University of Maryland Medical System. The most common first site of distant spread was bone (51%), followed by lung (17%), brain (16%), and liver (6%). The remaining 10% of @entity1 had multiple metastatic sites. Fewer than 10% of the entire group received adjuvant chemotherapy after primary treatment. When @entity3 appeared, most @entity1 had palliative systemic chemotherapy and/or irradiation. In general, @entity1 with initially negative axillary nodes had a longer median time until relapse (development of @entity3 ) and a longer survival time after diagnosis of @entity3 than @entity1 with initially positive nodes. Liver was the least common initial metastatic site; while liver @entity3 was seen only in @entity1 with positive axillary nodes, it carried the worst prognosis. The overall median survival time after @entity3 was 12 months for @entity79 , three months for @entity75 , and only one month for liver @entity3 . The median survival of @entity1 with multiple metastatic sites was 7.5 months. No correlation was found between time until relapse and survival after @entity3 . @entity1 in whom distant @entity3 developed relatively soon after the initial diagnosis had the same postmetastatic prognosis as @entity1 whose disease metastasized later. No correlation was found between age at initial diagnosis and @entity3 -free interval or survival after @entity3 .
