Radiation-induced XXXX after chemoradiotherapy for @entity356 .

@entity1 @entity130 @entity660 @entity3210 @entity1487 @entity356 @entity942
BACKGROUND AND PURPOSE: The pancreas is located almost entirely within the treatment area for radiotherapy of @entity356 . The aim of this study was to analyze radiation-induced @entity130 . MATERIAL AND METHODS: The study included 127 @entity356 @entity1 , who underwent preoperative or postoperative chemoradiotherapy. A total dose of 45Gy was given in 25 fractions. Concurrent chemotherapy was @entity1487 -based. Lipase and a-amylase were assayed before, during and after treatment. RESULTS: Lipase and @entity942 were found in 48.2% and 19.7% of @entity1 , respectively. In the univariant analysis, age and pretreatment a-amylase and lipase activities influenced on risk of @entity130 (p<0.05). Younger @entity1 (<65years) had a lower risk of hypoamylasemia than older @entity1 . The probability of insufficiency was lower than 0.2 for @entity1 with pretreatment a-amylase and lipase activities above 50U/L and 55U/L, respectively. The multivariate analyses of the time to hypolipasemia showed that only pretreatment lipase activity was significant. CONCLUSIONS: @entity356 @entity1 have an increased risk of exocrine @entity3210 after chemoradiotherapy. Thus, the pancreas should be regarded as an OAR. Measuring lipase activity should be the standard for assessing radiation-induced @entity660 .
