The preventive effect of XXXX on @entity409 after prostate biopsy: a prospective, open-label, observational study.

@entity1 @entity73 @entity409 @entity9940
OBJECTIVES: To evaluate the association of prostate biopsy with @entity73 and to investigate whether @entity9940 treatment given before prostate biopsy could improve @entity409 after the procedure. METHODS: The study included 88 consecutive @entity1 who underwent transrectal ultrasound-guided prostate biopsy without prior BPH medication and were prospectively randomized. Of these 88 @entity1 , 44 @entity1 underwent prostate biopsy only without @entity9940 treatment and served as the control group. The remaining 44 @entity1 were treated with @entity9940 (0.2  mg daily) beginning the day before the biopsy procedure for 7  days. The International Prostate Symptom Score (IPSS) was recorded in all @entity1 before the procedure and on postbiopsy day 7. Maximal flow rate (Q max) and postvoid residual urine volume were recorded in all @entity1 before the procedure and on postbiopsy days 1 and 7. RESULTS: No difference was found in baseline characteristics between the two groups. The IPSS (total, storage, and voiding symptom) was not significantly changed after biopsy in both groups. In the control group, the postvoid residual urine volume was increased on postbiopsy days 1 (P  <  0.05) and 7, and the Q max was significantly decreased on postbiopsy day 7 compared with the baseline value (P  <  0.05). In the @entity9940 group, Q max was significantly increased on postbiopsy days 1 and 7 (P  <  0.01). The postvoid residual urine volume was not increased on postbiopsy days 1 and 7. Acute urinary retention after the biopsy procedure did not develop in any of the @entity1 (0  %) in the @entity9940 group, but it developed in two @entity1 (4.5  %) of the control group. CONCLUSIONS: The results of our study show that prostate biopsy leads to objective @entity73 . Therefore, the use of alpha-1 blocker @entity9940 before biopsy in @entity1 without prior BPH medication may decrease this morbidity.
