Side-chain-specific lymphocyte responses in workers with occupational XXXX induced by penicillins.

@entity16393 @entity566 @entity114 @entity2490 @entity665 @entity68768 @entity3397 @entity56 @entity484
Eight workers with clinically diagnosed or suspected occupational @entity566 caused by penicillins were studied by the lymphocyte transformation test (LTT) and by skin test. The majority of the workers handled @entity16393 , some of them had been in contact with @entity3397 and one worked with @entity68768 only. Six workers had @entity484 and 2 workers suffered from @entity2490 only. Lymphocytes from workers with @entity16393 -induced symptoms responded to this drug in vitro by an increased @entity665 incorporation and by lymphoblastogenesis. @entity16393 -specific @entity566 had been confirmed by positive patch test in 5 workers. Lymphocytes from @entity16393 - @entity56 workers did not respond to other penicillins such as @entity3397 or @entity68768 in vitro. However, such penicillins were antigenic in vitro since lymphocytes from an @entity68768 patch test positive worker proliferated on exposure to @entity68768 in vitro. The findings at the cellular level were further supported by the specificity of the skin test. Thus, @entity16393 patch test positive workers had a negative skin reaction to @entity3397 . In conclusion, these data suggest the role of @entity114 side chains in the sensitization process underlying occupational @entity566 to penicillins. LTT can be used as a tool for studying antigenic specificities involved in a sensitization process leading to penicillin @entity566 .
