Relevance of XXXX VX2 Tumor Model for Studies on @entity1 Hepatocellular Carcinoma: A MicroRNA-Based Study.

@entity5 @entity1 @entity95 @entity146
MicroRNAs are small (~22 nt), noncoding RNA molecules that have critical cellular functions in proliferation, differentiation, angiogenesis and apoptosis. miRNA expression profiling has been used to create signatures of @entity5 and, in many cases, it has been shown to correlate with the severity of the disease. The @entity95 VX2 @entity5 model has been used widely to study a number of @entity1 @entity5 . Our objective in this study is to generate an miRNA signature of the VX2 @entity5 and to identify miRNAs that are highly expressed in this @entity146 . In this study, we performed miRNA profiling of the @entity95 VX2 @entity5 using a microarray that has probes for 1292 unique miRNAs. Their expression in @entity5 samples was quantified and analyzed. We found that 35 miRNAs were significantly up-regulated in the VX2 @entity5 . Among these, 13 @entity1 miRNAs and eight members of the let-7 family were previously identified in @entity5 . In addition, we show that the expression of three miRNAs (miR-923, miR-1275, and miR-1308) is novel for the @entity95 VX2 @entity5 , and their expression was not previously shown to be associated with any type of @entity5 . For the first time, we show the miRNA signature profile for a solid @entity5 in a @entity95 model. miRNAs highly expressed in the VX2 @entity5 may serve as novel candidates for molecular biomarkers and as potential drug targets.
