Sudomotor function in XXXX .

@entity1 @entity1131 @entity16 @entity10751 @entity2537 @entity1119 @entity4148 @entity56 @entity934
BACKGROUND: @entity1 with @entity10751 ( @entity10751 ) manifest @entity1119 despite the @entity2537 and sweat glands associated with this @entity4148 . We assessed peripheral sudomotor nerve fibre and sweat gland function to determine if this symptom was due to peripheral denervation @entity56 . METHODS: In 14 @entity10751 @entity1 and 11 healthy controls, direct and axon reflex mediated sweat responses were determined by measuring transepidermal water loss (TEWL) after application of @entity934 via a microdialysis membrane, a novel method to evaluate sudomotor function in @entity16 @entity1 . Results were compared with data from conventional quantitative sudomotor axon reflex testing (QSART). Using microdialysis, interstitial fluid was analysed for plasma proteins to evaluate @entity1131 induced by @entity934 as an additional parameter of C-fibre function. RESULTS: Although reduced axon reflex sweating was expected in @entity10751 @entity1 , neither direct or axon reflex mediated sweat responses, nor @entity934 induced @entity1131 differed between control and @entity1 groups. However, the baseline resting sweat rate was higher in @entity10751 @entity1 than controls (p<0.05). TEWL and QSART test results correlated (r = 0.64, p = 0.01), proving the reliability of TEWL methodology in evaluating sudomotor function. CONCLUSION: The finding of normal direct and axon reflex mediated sweat output in @entity10751 @entity1 supports our hypothesis that, in a disorder with severe sympathetic nerve fibre @entity2537 , but not the sweat gland itself, exhibit @entity56 . This might explain excessive @entity1119 in situations with increased central sympathetic outflow.
