XXXX , @entity2340 immobilized chitosan beads as adsorbents for selective removal of immunoproteins.

@entity1 @entity1522 @entity2002 @entity26408 @entity1423 @entity3584 @entity2340 @entity1200 @entity815
The use of adsorbents for the treatment of @entity1 suffering from various @entity1200 is still in its infancy. Therefore, the development of selective absorbents for the removal or decrease of immunoproteins from plasma is of great importance. In this study, chitosan, a natural polysaccharide having structural characteristics similar to glycosamino glycans, which is non-toxic and biocompatible, has been used for protein adsorption studies. @entity1522 like @entity815 and @entity2340 in different ratios are bonded to these polymers to observe immunoadsorption. Several layers of @entity815 or @entity2340 have been coated covalently on chitosan beads using N2-plasma, @entity26408 or @entity3584 treatments. Scanning electron micrographs have revealed the surface morphological changes after such modifications. The surface modified chitosan beads have exhibited high binding affinity for gamma-globulin compared to bare beads. It is also observed that the amount of @entity2002 adsorption is reduced on modified substrate. A selective removal of IgG and IgM has also been observed with these modified matrix when tested with @entity1 plasma, using immuno diffusion methods. The modified chitosan membranes have demonstrated a @entity1423 , showing that these substrates have become more blood compatible. Hence, it appears that modified chitosan surfaces may be an excellent sorbent system for haemoperfusion due to their high binding affinity for immunoproteins and blood compatibility. Further studies are needed to determine the behaviour under clinical conditions.
