@entity21378 fragments are prognostic biomarkers of @entity571 incidence in overweight and @entity28 XXXX .

@entity1 @entity71057 @entity626 @entity571 @entity28 @entity21378 @entity158
OBJECTIVE: To determine the association between three @entity21378 peptides and the incidence of radiographic and clinical @entity626 ( @entity571 ). DESIGN: @entity1 between 50 and 60 years, with a BMI >= 27  kg/m(2), free of knee @entity571 , were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, @entity71057 -2 and @entity71057 -3 and incidence of clinical and radiographic knee @entity571 after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 @entity1 with a mean age of 55.9      3.2 years and mean BMI of 31.7      3.6  kg/m(2). None of the concentrations of the three @entity71057 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >= 1.0  mm or the incidence of Kellgren _ Lawrence (K_L) grade >= 2 after 30 months. All three @entity71057 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and @entity71057 -1 and @entity71057 -3 also with chronic @entity158 at follow-up. When adjusted for the other @entity71057 peptide concentrations, only @entity71057 -1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic @entity158 at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline @entity21378 concentrations are associated with the incidence of clinical knee @entity571 among middle-aged overweight and @entity28 @entity1 . Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for @entity571 . Further validation of the @entity21378 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee @entity571 development.
