Infrasound-induced hemodynamics, ultrastructure, and molecular changes in the XXXX myocardium.

@entity1423 @entity141 @entity11474 @entity35 @entity1002
Recent interest in adverse effects of infrasound on organisms arises from health concerns. We assessed the association between infrasound exposure of 5 Hz at 130 dB and changes of cardiac ultrastructure and function in @entity35 . Thirty-two @entity35 were randomized into control, 1, 7, and 14 days groups for 2 h of infrasound once daily according to planned schedules. Changes of cardiac ultrastructure, hemodynamics indices, intracellular @entity141 concentrations ([ @entity141 ](i)), and sarcoplasmic reticulum @entity141 -ATPase 2 ( @entity11474 ) were detected. Heart rates in 1 day group were significantly increased compared with control group and no significant changes in other groups. @entity1002 were significantly increased with time. Left ventricular diastolic end pressure and maximum rising rates of left ventricular pressure (+dl/dt) were significantly increased in 7 and 14 days groups and not changed in 1 day group, compared with control group. Maximum dropping rates of left ventricular pressure (-dl/dt) were significantly decreased in 7 and 14 days groups and not changed in 1 day group, compared with control group. In heart cells, there were several swelled mitochondria in 1 day group, more swelled mitochondria in 7 days group, @entity1423 in the intercellular substance in 14 days group. [ @entity141 ](i) were significantly increased with time. There was a significant increase in @entity11474 in 1 day group, while a significant decrease in 7 and 14 days groups, compared with control group. Infrasound of 5 Hz at 130 dB can damage cardiac ultrastructure and function. Changes of [ @entity141 ](i) and @entity11474 play an important role in the secondary cardiac damage.
