Plasma levels of soluble @entity2936 ligand are elevated in XXXX .

@entity1 @entity32 @entity2936 @entity31 @entity11603 @entity294 @entity29 @entity292 @entity30
BACKGROUND AND AIMS: @entity2936 / @entity11603 ( @entity11603 ) interaction is important for induction of T cell dependent antibody production and cell-mediated immune responses. Overexpression of @entity2936 / @entity11603 in the intestinal mucosa is likely to be involved in the pathogenesis of @entity29 ( @entity29 ). A soluble form of @entity11603 (sCD40L) exists in the circulation. This study investigated whether plasma levels of sCD40L are higher in @entity1 with @entity29 than in healthy controls. @entity1 AND METHODS: Plasma levels of sCD40L were measured in 89 @entity1 with @entity30 ( @entity30 ), 56 @entity1 with @entity31 ( @entity31 ), 17 @entity1 with @entity294 , and 42 healthy controls, using a specific enzyme-linked immunosorbent assay. RESULTS: In @entity30 @entity1 plasma levels of sCD40L were significantly higher than in healthy controls. @entity1 with @entity31 and @entity294 had higher sCD40L levels than healthy controls, but the differences were not significant. @entity30 @entity1 with @entity292 and/or abscesses (n=38) had significantly higher levels of sCD40L than @entity1 with uncomplicated @entity30 (n=51). Only in @entity1 with uncomplicated @entity30 plasma levels of sCD40L correlated significantly with C-reactive protein and alpha(1)-glycoprotein. In @entity31 @entity1 there was a significant correlation of sCD40L with C-reactive protein. However, there was no significant correlation between plasma sCD40L levels and @entity30 activity index or Rachmilewitz score. CONCLUSION: Elevated plasma levels of sCD40L in @entity30 @entity1 supposedly reflect activation of functional @entity11603 in the intestine and might be a marker of intestinal @entity32 .
