Outcomes of trimodality approach in the management of T2N0M0 XXXX .

@entity1 @entity8 @entity150 @entity137
AIMS AND BACKGROUND: The main objective of this study is to evaluate outcomes of bladder preservation treatment for @entity1 with @entity150 . METHODS AND STUDY DESIGN: 38 @entity1 with histologically proven @entity150 treated at our department between January 2008 and December 2013 were analyzed retrospectively. Age, gender, pathology, stage, 3-year overall survival, 3-year disease-free survival, radiotherapy (RT) dose, genitourinary and gastrointestinal @entity137 scores and response evaluation of the @entity1 were recorded. 3-year overall survival and 3-year disease-free survivals were calculated by Kaplan-Meier method along with the analysis of gender, pathology, stage and therapy response of the study group. RESULTS: 33 @entity1 (86.8%) were managed with concomitant chemoradiotherapy whereas 5 @entity1 (13.2%) received only radiation therapy due to @entity8 . 6 (15.8%) out of 38 @entity1 had partial response (PR) and remaining 32 (84.2%) @entity1 experienced complete response (CR). The PR group underwent salvage cystectomy and CR group had been followed-up after radical radiotherapy. Mean age of the group was 70.9 (range 45-90) years. 26 of all @entity1 were male (68.4%) and 12 were female (31.6%). Mean follow-up time after completion of radiotherapy was 24.7 months (range 12-40). Mean RT dose was 64 Gy (range 60-66). 3-year overall survival was 64% and 3-year disease free survival was 73%. CONCLUSIONS: Bladder preserving approach is an alternative definitive therapy solution to radical cystectomy in the treatment of @entity150 with less morbidity, preserved natural bladder, and high quality of life.
