Ischemic basis for deep XXXX in @entity308 : a neuropathological study.

@entity62 @entity308 @entity2806 @entity63
BACKGROUND: @entity62 on magnetic resonance imaging are increased in major @entity62 , especially in frontal areas. These lesions have been hypothesized to be @entity63 in origin, but there have been no previous neuropathological studies in @entity308 . We investigated the neuropathological basis of these lesions in @entity308 , hypothesizing that they would be more frequently @entity63 in origin in depressed subjects. METHODS: We carried out in vitro magnetic resonance imaging on 3 slices of brain tissue (2 frontal, 1 occipital) from 20 elderly subjects who had a history of @entity308 and 20 elderly controls. The films were blindly rated, and sections were prepared for neuropathological analysis from the same slices and stained conventionally and by means of immunohistochemistry for microglia, macrophages, and astroglia. Lesions on the films were identified in the tissue, blindly described neuropathologically, and subsequently divided into @entity63 and nonischemic lesions. RESULTS: All the deep @entity62 in the depressed group were found to be @entity63 , compared with less than a third of those in the control group, a highly significant difference (P<.001). This difference was due to smaller punctate lesions (<3 mm), which were predominantly @entity63 in depressed subjects but not in control subjects. Larger lesions were usually @entity63 in both groups. Compared with control subjects, @entity2806 were significantly more likely to be in the dorsolateral prefrontal cortex compared with the anterior cingulate cortex (P =.003) and the occipital cortex (P =.01) in the depressed subjects. CONCLUSIONS: Deep @entity62 are more frequently due to @entity2806 , and such @entity2806 are more frequently located at the level of dorsolateral prefrontal cortex in depressed subjects. Our findings strongly support the " @entity308 " @entity308 .
