Impact of @entity689 inhibitors on @entity683 A(H1N1)pdm09-related XXXX : an individual @entity1 data meta-analysis.

@entity689 @entity1 @entity778 @entity17731 @entity55 @entity683
BACKGROUND: The impact of @entity689 inhibitors (NAIs) on @entity683 -related @entity55 ( @entity17731 ) is not established. Our objective was to investigate the association between NAI treatment and @entity17731 incidence and outcomes in @entity1 hospitalised with A(H1N1)pdm09 @entity778 . METHODS: A worldwide meta-analysis of individual @entity1 data from 20 634 hospitalised @entity1 with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic @entity683 '. The primary outcome was radiologically confirmed @entity17731 . Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. RESULTS: Of 20 634 included @entity1 , 5978 (29  0%) had @entity17731 ; conversely, 3349 (16  2%) had confirmed the absence of radiographic @entity55 (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with @entity17731 [adj. OR 0  83 (95% CI 0  64-1  06; P = 0  136)]. Among the 5978 @entity1 with @entity17731 , early NAI treatment versus none did not impact on mortality [adj. OR = 0  72 (0  44-1  17; P = 0  180)] or likelihood of requiring ventilatory support [adj. OR = 1  17 (0  71-1  92; P = 0  537)], but early treatment versus later significantly reduced mortality [adj. OR = 0  70 (0  55-0  88; P = 0  003)] and likelihood of requiring ventilatory support [adj. OR = 0  68 (0  54-0  85; P = 0  001)]. CONCLUSIONS: Early NAI treatment of @entity1 hospitalised with A(H1N1)pdm09 @entity778 versus no treatment did not reduce the likelihood of @entity17731 . However, in @entity1 who developed @entity17731 , early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.
