Systemic absorption of topical @entity3303 in a bone marrow transplant recipient with hepatic XXXX .

@entity1 @entity382 @entity981 @entity882 @entity648 @entity409 @entity3118 @entity1897 @entity3303 @entity1398 @entity1891 @entity5501 @entity1863 @entity492 @entity493 @entity9
PURPOSE: A case of systemic @entity3303 exposure in a bone marrow transplant recipient with severe hepatic @entity5501 ( @entity5501 ) receiving treatment with @entity3303 patch 5% is reported. SUMMARY: A 35-year-old Caucasian @entity1 with a history of refractory @entity981 was admitted for a third allogeneic, mismatched, peripheral blood hematopoietic stem cell transplant from an unrelated donor, with a conditioning regimen that included @entity1863 and @entity3118 . The @entity1 was receiving treatment with @entity3303 patch 5% (two patches daily, which was started five months before another hospital admission for the treatment of @entity1891 -related @entity1897 . Baseline laboratory findings were within normal limits except for disease-related @entity1398 and @entity882 . Twenty days after hematopoietic stem cell transplantation (HSCT), the @entity1 developed signs and symptoms of severe hepatic @entity5501 . His serum @entity493 transaminase concentration rose from 65 IU/L at baseline to 370 IU/L, and his serum @entity492 transaminase concentration rose from 32 IU/L at baseline to 871 IU/L. His total @entity648 increased to 2.8 mg/dL, and his body weight increased by 15%. An abdominal ultrasound noted ascites and @entity382 without reversal of blood flow. The @entity3303 patch was discontinued, but the @entity1 's condition continued to deteriorate. He died 38 days after HSCT from complications of severe hepatic @entity5501 . CONCLUSION: A 35-year-old @entity1 developed hepatic @entity5501 20 days after his third HSCT. As a result of his @entity409 , the @entity1 , who had been receiving @entity3303 patch 5% for the treatment of @entity9 , experienced increased systemic exposure to @entity3303 , which led to discontinuation of the patch.
