Particular outcomes of XXXX : stunning and hibernation.

@entity296 @entity39 @entity908 @entity409 @entity880 @entity1562 @entity67 @entity1002
There are several potential outcomes of @entity296 . When ischaemia is severe and prolonged, irreversible damage occurs and there is no recovery of contractile function. When @entity296 is less severe but still prolonged, myocytes may remain viable but exhibit depressed contractile function. Under these conditions, reperfusion restores complete contractile performance. This type of ischaemia, leading to a reversible, chronic @entity1002 , has been termed hibernating @entity1562 . The difference between this condition and that described before, i.e. prolonged ischaemia, which results in further damage on reperfusion, is, most likely, related to residual coronary flow. In the hibernating @entity1562 , which is supplied by a narrow coronary artery, blood flow is not low enough to cause progression toward tissue @entity39 , but it is low enough to cause intracellular changes and adaptative mechanisms which, in turn, are responsible for the down-regulation of myocardial contractility and for the preservation of viability. The level of underperfusion is sufficient to maintain aerobic metabolism of the quiescent @entity1562 as demonstrated by the absence of @entity880 and @entity908 phosphokinase releases. There are no doubts that revascularization is essential for hibernating @entity1562 , and the clinical goal to achieve is the possibility of accurately distinguishing viable from infarcted tissue. A third possible outcome of @entity296 is a post-ischaemic @entity67 or @entity1562 . This term describes a transient @entity409 that persists on reperfusion after a short period of ischaemia, despite the absence of irreversible damage.
