Safety and efficacy of the Perclose suture-mediated closure device following carotid artery stenting under XXXX platelet blockade.

@entity1 @entity1397 @entity2948 @entity117 @entity281 @entity1410 @entity2548 @entity2849
The aim of this study was evaluation of a closure device (Perclose, Menlo Park, @entity2948 .) for closure of the femoral artery access site in @entity1 undergoing aggressive anticoagulation and platelet blockade after carotid stenting. Fifty-five @entity1 who received @entity1397 in addition to @entity117 and heparin as medication for carotid stenting were included for suture of the femoral access site after using 7- or 8-F guide catheters. The technical success, the time for suture, the clotting parameters, and complications were examined. Follow-up investigations, including ultrasound and clinical examinations, were performed. The groin was checked for possible @entity1410 , @entity2849 , @entity2548 , and @entity281 . Technical success was obtained in 51 of 54 @entity1 (94%) after a mean procedure time of 6 min (range 5-10 min). The suture device was not used in one @entity1 (2%) for anatomical reasons and failed to obtain hemostasis in 3 of 54 (6%) @entity1 . In 4 of 54 @entity1 (7%) bleeding was observed at the punctured site 4-6 h after intervention which was treated by a compression bandage. The mean dedicated activated clotting time was 137 s (range 29-287 s) before intervention and 349 s (150-958 s) just before deploying the Perclose device. During follow-up after 2 days (range 2-6 days) and 6 months no further complications of the puncture site were observed except for two large groin @entity1410 . No major complications occurred. Closure of the femoral access site after carotid stenting using a Perclose closure device is safe and effective even in @entity1 receiving an aggressive anticoagulation and antiplatelet therapy.
