Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black XXXX .

@entity1 @entity263 @entity2301 @entity1067 @entity442
OBJECTIVES: To examine the relationship between @entity442 ( @entity442 ), @entity2301 ( @entity2301 ), and body mass index and prostate volume, as a surrogate marker for @entity1067 , in a community-based sample of black @entity1 . Epidemiologic studies examining the role of @entity442 and @entity2301 suggest that increased levels of serum @entity442 and decreased levels of serum @entity2301 are associated with an increased risk of @entity263 . Few studies have examined these factors with respect to @entity1067 , and these have been limited to white @entity1 . METHODS: The study population consisted of a sample of 364 black @entity1 , 40 to 79 years of age, residing in Genesee County, Michigan. @entity1 with @entity263 or prior prostate surgery were excluded. All subjects completed a clinical examination, which included a complete urologic examination with transrectal ultrasonography, anthropometric measurements, and serum assays for @entity442 and @entity2301 . RESULTS: Multivariable regression models demonstrated that prostate volume increased with increasing age (P <0.0001) and body mass index (P = 0.03). @entity2301 rather than @entity442 was positively associated with increasing prostate volume (P = 0.003). CONCLUSIONS: This is the largest study describing the relationships between @entity442 , @entity2301 , and body mass index and prostate volume, and the only study in black @entity1 . Although earlier studies demonstrated an association between @entity442 and @entity263 risk, our findings indicate that @entity2301 is more relevant for prostate enlargement, suggesting that @entity442 and @entity2301 may play different pathophysiologic roles in benign and malignant prostatic conditions.
