Clinical efficacy of three common treatments in XXXX in primary care: randomised controlled trial.

@entity1 @entity228 @entity134 @entity12088 @entity1543 @entity288
OBJECTIVE: To compare the clinical efficacy of ear drops containing @entity1543 , @entity228 and @entity1543 , and @entity134 and antibiotic in @entity12088 in primary care. DESIGN: Randomised controlled trial. SETTING: 79 general practices, Netherlands. @entity1 : 213 adults with @entity12088 . MAIN OUTCOME MEASURES:                 <AbstractText Label="PRIMARY OUTCOME" NlmCategory="METHODS">duration of symptoms (days) according to @entity1 diaries. Secondary outcome: cure rate according to general practitioner completed questionnaires and recurrence of symptoms between days 21 and 42. RESULTS: Symptoms lasted for a median of 8.0 days (95% confidence interval 7.0 to 9.0) in the @entity1543 group, 7.0 days (5.8 to 8.3) in the @entity134 and @entity1543 group, and 6.0 days (5.1 to 6.9) in the @entity134 and antibiotic group. The overall cure rates at seven, 14, and 21 days were 38%, 68%, and 75%, respectively. Compared with the @entity1543 group, significantly more @entity1 were cured in the @entity134 and @entity1543 group and @entity134 and antibiotic group at day 14 (odds ratio 2.4, 1.1 to 5.3, and 3.5, 1.6 to 7.7, respectively) and day 21 (5.3, 2.0 to 13.7, and 3.9, 1.7 to 9.1, respectively). Recurrence of symptoms between days 21 and 42 occurred in 29% (50/172) of @entity1 and was seen significantly less in the @entity134 and @entity1543 group (0.3, 0.1 to 0.7) and @entity134 and antibiotic group (0.4, 0.2 to 1.0) than in the @entity1543 group. CONCLUSIONS: Ear drops containing @entity288 are more effective than @entity1543 ear drops in the treatment of @entity12088 in primary care. @entity134 and @entity1543 or @entity134 and antibiotic ear drops are equally effective.
