Potentiation of the protective effects of a converting enzyme inhibitor and a @entity2871 synthetase inhibitor in XXXX .

@entity2871 @entity12827 @entity71015 @entity296 @entity548 @entity4689 @entity33283 @entity3448 @entity35 @entity551
The effect of a specific inhibitor of @entity2871 (Tx) A2 synthesis, @entity33283 , a new angiotensin converting enzyme inhibitor, @entity71015 , and a combination of both drugs was studied in @entity548 in @entity35 . Treatment with @entity71015 (1 microgram/kg) or @entity33283 (200 micrograms/kg) alone did not alter significantly postoligemic @entity551 or the increase in plasma @entity12827 activity in shocked @entity35 , compared with hemorrhaged @entity35 receiving only their vehicle. Combined treatment with both drugs maintained postreinfusion mean arterial blood pressure and attenuated the increase in plasma @entity12827 activity in hemorrhaged @entity35 . Treatment of shocked @entity35 with each drug alone attenuated the accumulation of a @entity296 factor activity in the plasma, but the lowest @entity296 factor activities were observed in @entity35 treated with the drug combination. Additionally, animals treated with the drug combination exhibited significantly longer postreinfusion survival times than @entity35 receiving either the vehicle (P less than .01), @entity71015 (P less than .05) or @entity33283 (P less than .02). @entity71015 (1 microgram/kg) attenuated significantly the pressor response to @entity4689 throughout the shock period. @entity33283 attenuated the increase in TxB2 plasma concentrations in shock when compared with hemorrhaged @entity35 receiving the vehicle (P less than .05). Greater attenuation of @entity3448 was found after treatment with the drug combination (P less than .01 from vehicle, P less than .05 from @entity33283 alone). @entity71015 , but not @entity33283 , was also found to have a direct antiproteolytic action in pancreatic homogenates. However, the drug combination ( @entity71015 and @entity33283 ) decreased proteolytic activity even further (P less than .001) from @entity71015 alone.(ABSTRACT TRUNCATED AT 250 WORDS)
