Comparison of estimated glomerular filtration rates and @entity633 in predicting risk of @entity301 in a population with high prevalence of XXXX and @entity8 .

@entity1 @entity8 @entity6 @entity301 @entity633
Improved accuracy in predicting @entity301 ( @entity301 ) risk in @entity1 with @entity6 and @entity8 is needed. The addition of @entity633 to established methods of @entity301 risk calculation was reported in the Strong Heart Study (SHS) cohort. In this study, the addition of estimated glomerular filtration rate (eGFR) was evaluated using data from 4,549 American Indian SHS @entity1 aged 45 to 74 years. After adjustment for Framingham @entity301 risk factors, hazard ratios for eGFR as a predictor of @entity301 were 1.69 (95% confidence interval 1.34 to 2.13) in @entity1 and 1.41 (95% confidence interval 0.94 to 2.13) in @entity1 . Models including @entity633 , eGFR, or both scored higher in discriminatory power than models using conventional risk factors alone in @entity1 ; in @entity1 , the improvement was seen only for @entity633 and the combination of @entity633 and eGFR. Hosmer-Lemeshow assessments showed good calibration for the models using eGFR alone in both genders, followed by models including @entity633 alone in both genders. Adding eGFR improved the net reclassification improvement (NRI) in @entity1 (0.085, p = 0.0004) but not in @entity1 (0.010, p = 0.1967). NRI and integrated discrimination improvement (IDI) were improved in both genders using @entity633 and eGFR (NRI 0.135, p <0.0001, and IDI 0.027, p <0.0001 in @entity1 ; NRI 0.035, p <0.0196, and IDI 0.008, p <0.0156 in @entity1 ). Therefore, a risk calculator including @entity633 enhances @entity301 prediction compared to a calculator using only standard risk factors in @entity1 and @entity1 . Including eGFR alone improves risk prediction in @entity1 , but for @entity1 , it is preferable to include eGFR and @entity633 . In conclusion, this enhanced calculator should be useful in estimating @entity301 risk in populations with high prevalence of @entity6 and @entity8 .
