[Post-recurrence survival after surgical resection of XXXX with local recurrence].

@entity1 @entity168 @entity1149 @entity1726 @entity3
We retrospectively evaluated the clinical outcomes of 192 consecutive @entity1 with local recurrence after complete resection of @entity1149 (NSCLC). The initial local recurrent site was the resection stump in 5 @entity1 (the chest wall in 3 @entity1 , mediastinum in 1 @entity1 , and diaphragm in 1 @entity1 ), and the hilar and/or mediastinal lymph node (HMLN)in 17 @entity1 . The sites of distant @entity3 were the lungs in 10 @entity1 , pleura in 4 @entity1 , brain in 7 @entity1 , liver in 5 @entity1 , bone in 4 @entity1 , and other sites in 4 @entity1 . Treatments after initial recurrence included surgery in 2 @entity1 , radiotherapy in 5 @entity1 , chemotherapy in 9 @entity1 , and chemo-radiotherapy in 5 @entity1 . Only 1 @entity1 received supportive care. The response to radiotherapy was a complete response(CR)in 1 @entity1 , partial response(PR)in 5 @entity1 , stable disease( @entity168 )in 3 @entity1 , and progressive disease( @entity1726 )in 1 @entity1 . The best response of all lines of chemotherapy was CR in 3 @entity1 , PR in 4 @entity1 , @entity168 in 3 @entity1 , and @entity1726 in 4 @entity1 . The median post-recurrence survival(PRS)time with local recurrence was better than that with distant @entity3 (23 vs 14 months); however, the best PRS was obtained in @entity1 with recurrence in the lungs(29 months). A CR for more than 2 years was obtained in 1 @entity1 after surgery, in 1 @entity1 after radiotherapy, and in 2 @entity1 after chemotherapy. Although local recurrence of resected NSCLC can be potentially controlled by using local treatments - such as surgery and radiotherapy - or systemic chemotherapy, curative aggressive treatment should be considered when required.
