Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in XXXX .

@entity1 @entity30026 @entity72790 @entity1468 @entity72789
AIMS: We evaluated if killer cell immunoglobulin-like receptor 3DL2 gene ( @entity30026 ) polymorphisms are a key factor in the development of @entity1468 . METHODS: In this case-control study, 105 pregnant @entity1 with PE (PE group) were enrolled. Their @entity72789 in exon 3 and @entity72790 in exon 9 polymorphisms of the @entity30026 genotypes were determined by polymorphism chain reaction-restriction fragment length polymorphism (PCR-RFLP) from venous blood samples and compared with the corresponding @entity30026 genotypes of 103 pregnant @entity1 with uncomplicated pregnancies (control group). RESULTS: Carriers of the A allele in exon 3 of @entity30026 gene occurred less frequently in PE than in controls [P=0.001; odds ratio (OR)=2.65, range: 1.5-4.7]. No significant difference was found about allelic frequencies of @entity30026 gene @entity72790 in exon 9 in @entity1 with @entity1468 as compared to controls. A significant difference between the two groups of genotypic frequencies of @entity30026 gene @entity72789 in exon 3 and @entity30026 gene @entity72790 in exon 9 polymorphisms was found (P=0.003 and P=0.000). There was no significant difference between genotypic or allelic frequencies in @entity1 with mild @entity1468 compared to sever @entity1468 . CONCLUSIONS: Our results suggest that carriers of A allele in exon 3 have a decreased susceptibility to PE. It is likely that the presence of the CC genotype in exon 9 has a considerable effect on disease progression. The mutation of the two sites is not associated with the severity of @entity1468 .
