Characteristics of upper urothelial carcinoma in an area of XXXX in south Serbia. A fifty-year retrospective study.

@entity1 @entity8 @entity5 @entity22412 @entity1606 @entity4759
AIMS AND BACKGROUND: Upper urinary tract @entity1606 , a relatively rare @entity5 , is up to 100 times more frequent in regions with @entity8 . Characteristics of @entity1606 in the @entity4759 South Morava Region in Serbia in the previous 50 years were evaluated. @entity1 : We analyzed 477 cases with pathologically confirmed @entity1606 who underwent surgery from 1957 to 2006: 91 from @entity4759 , 106 from adjacent and 280 from control settlements. Cases in the study came from 10 @entity4759 villages, 46 adjacent villages, 51 control villages and the city of @entity22412 . RESULTS: The increase in @entity1606 from 1957 was followed by a peak between 1967 and 1978 (yearly incidence 21.9 per 100,000) and a slow decrease thereafter to 7.4 (1997-2006). In the control settlements, the increase was steady. Reduced kidney function at surgery was found in 58% of @entity1 from @entity4759 and in 20% from control settlements. Age at surgery has significantly increased from 52.3 and 51.5 (1957-1966) to 70.9 and 66.1 (1997-2006) for @entity4759 and control settlements, respectively. The female sex was predominant in @entity4759 and adjacent settlements and the male sex in control settlements. @entity1606 from @entity4759 settlements was of a lower grade in the period from 1957-1986, but in the period from 1987-2006 they were predominantly high grade. @entity5 stage (pTa-pT1) predominated in @entity1606 from the @entity4759 and adjacent but not the control settlements in the period from 1957 to 1986. However, in the last 20 years, upper urinary tract @entity1606 stage increased, the highest in the period from 1997 to 2006 in all settlements studied. Conservative surgery was advocated for @entity1606 in @entity8 areas up to 1996. @entity1606 are now more malignant and more advanced than before, and a less aggressive approach is used only for absolute indications. CONCLUSIONS: An increased @entity1606 in @entity4759 settlements was observed, markedly decreasing in the last decade. An increasing age and a shorter survival were recorded in @entity1 both from @entity8 and control settlements. Sporadic cases upper urinary tract @entity1606 in settlements adjacent to @entity4759 settlements were demonstrated.
