Hemodynamic-morphological discriminant models for XXXX remain stable with increasing sample size.

@entity397 @entity439 @entity1756
BACKGROUND: We previously established three logistic regression models for discriminating @entity1756 status based on morphological and hemodynamic analysis of 119 @entity439 . In this study, we tested if these models would remain stable with increasing sample size, and investigated sample sizes required for various confidence levels (CIs). METHODS: We augmented our previous dataset of 119 @entity439 into a new dataset of 204 samples by collecting an additional 85 consecutive @entity439 , on which we performed flow simulation and calculated morphological and hemodynamic parameters, as done previously. We performed univariate significance tests on these parameters, and multivariate logistic regression on significant parameters. The new regression models were compared against the original models. Receiver operating characteristics analysis was applied to compare the performance of regression models. Furthermore, we performed regression analysis based on bootstrapping resampling statistical simulations to explore how many @entity439 cases were required to generate stable models. RESULTS: Univariate tests of the 204 @entity439 generated an identical list of significant morphological and hemodynamic parameters as previously (from the analysis of 119 cases). Furthermore, multivariate regression analysis produced three parsimonious predictive models that were almost identical to the previous ones, with model coefficients that had narrower CIs than the original ones. Bootstrapping showed that 10%, 5%, 2%, and 1% convergence levels of CI required 120, 200, 500, and 900 @entity439 , respectively. CONCLUSIONS: Our original hemodynamic-morphological @entity397 models are stable and improve with increasing sample size. Results from resampling statistical simulations provide guidance for designing future large multi-population studies.
