Trefoil peptide expression and goblet cell number in @entity35 intestine: effects of XXXX and fasting-refeeding.

@entity54304 @entity851 @entity11943 @entity49012 @entity71012 @entity35
The trefoil factor family peptides @entity49012 , @entity71012 , and @entity54304 are important for gut mucosal protection and restitution. @entity11943 ( @entity11943 ) stimulates proliferation and differentiation of epithelial cells with potent effects on goblet cells. To investigate interactions between food intake and @entity11943 , @entity35 were fed ad libitum (control), fasted for 72 h, or fasted for 72 h and then refed for 72 h with or without @entity11943 (3 mg. kg(-1). day(-1)). With fasting, goblet cell number in duodenum increased, @entity54304 mRNA in duodenum and jejunum decreased, and @entity54304 protein did not change or increased. @entity11943 during fasting stimulated colonic growth, normalized @entity54304 mRNA in duodenum and jejunum, and broadly upregulated gut goblet cell number and @entity54304 protein expression. With fasting-refeeding, @entity11943 increased small bowel and @entity851 , goblet cell number, and @entity54304 protein but had variable effects on @entity54304 mRNA. @entity11943 induced @entity71012 mRNA and protein in duodenum and jejunum with both nutritional regimens. We conclude that nutrient availability modifies @entity35 intestinal goblet cell number, @entity54304 mRNA, and the gut-trophic effects of @entity11943 in a region-specific manner. @entity11943 enhances @entity71012 expression in proximal small bowel and increases goblet cell number and @entity54304 protein content throughout the intestine independent of food intake.
