Long term antihypertensive drug use and XXXX risk: A 9-year population-based cohort analysis.

@entity1 @entity263 @entity101 @entity5 @entity204
BACKGROUND: Recent findings from clinical trials have indicated inconsistent associations between angiotensin II receptor blockers and the risk of @entity5 incidence. Furthermore, the relationship between antihypertensive drugs and @entity263 in @entity101 @entity1 remains unclear. METHODS: From Taiwan's national health insurance database, we identified 80,299 @entity1 diagnosed with @entity101 in 2001 and matched with 321,916 subjects without @entity101 by age, income, urbanization level, and index day. A total of 684 @entity101 patients without antihypertensive drug use (drug non-user subcohort) were also matched (1:4) with 2736 patients on antihypertensive medication (drug subcohort) using the same criteria. Each subject in the two study groups was followed up for a maximum of nine years, during which @entity204 was considered a competing event when performing the stratified Fine and Gray regression hazards model for the estimation of @entity263 risk for the cohorts. Uptake of antihypertensive prescription was considered a time-dependent variable. RESULTS: Our findings indicate that @entity1 with @entity101 are at significantly increased risk for @entity263 incidence when compared to their matched non- @entity101 counterparts (sHR=6.80, 95% CI=1.97-23.44, p=0.0024). Among @entity101 @entity1 , those with long term antihypertensive drug use are not at elevated risk of developing @entity263 relative to non-users of antihypertensive drugs (1-5year vs. non-user sHR=0.99, 95% CI=0.32-3.05; >5year vs. non-user sHR=0.88, 95% CI=0.34-2.26). CONCLUSIONS: @entity101 is considered a risk factor for @entity263 . However, long term uptake of antihypertensive medication in male @entity101 @entity1 should not be a concern for the development of @entity263 .
