[Initial bone marrow involvement in XXXX (author's transl)].

@entity1 @entity978 @entity3308 @entity1503
Twenty-five @entity1 with @entity978 and evidence of bone marrow involvement (BM +) were compared with 25 other Hodgkin @entity1 , chosen at random, who had visceral lesions but free bone marrow (BM -). Both groups were observed throughout the same period. The first evaluation showed that bone marrow involvement was more frequent in male @entity1 and that it produced @entity3308 with WBC and platelet counts lower than in BM - @entity1 . However, bone marrow involvement can only be ascertained by medullar biopsy. BM + @entity1 were treated with multiple chemotherapy (mostly MOPP). Positive response was obtained in 64% and complete remission in 50%, as compared with 70% and 50% respectively in BM - @entity1 . There was no significant difference in overall survival rate between the two groups. It remained in plateau at 50.5% after two years in BM + @entity1 and at 63% after 27 months in BM - @entity1 . When complete remission was obtained the survival rate after one year was 90% for BM + @entity1 and 100% for BM - @entity1 . In the absence of complete remission, however, the median survival time was inferior to one year in both groups. The dosage levels and side-effects of chemotherapeutic agents were similar in both groups, but @entity1503 was more pronounced in BM + @entity1 .
