MR elastography of the liver at 3.0 T in diagnosing XXXX grades; preliminary clinical experience.

@entity1575 @entity1 @entity409 @entity82
OBJECTIVES: To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of @entity1575 using preliminary clinical data. MATERIALS AND METHODS: Between November 2012 and March 2014, MRE was applied to all @entity1 who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3  months from MR examinations were retrospectively recruited, and the @entity409 measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent. RESULTS: There were 70 @entity1 who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of @entity1575 (rho   =   0.89, p   <   0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for @entity82 score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38  kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected @entity409 , but to a significantly lesser degree as compared to @entity82 . CONCLUSIONS: 3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of @entity1575 . KEY POINTS:     MR elastography may help clinicians assess @entity1 with chronic @entity409     Usefulness of 3.0-T MR elastography has rarely been reported     Measured @entity409 correlated well with the histological grades of @entity1575     Measured @entity409 was also affected by necroinflammation, but to a lesser degree     3.0-T MRE could be a non-invasive alternative to liver biopsy.
