The effect of XXXX on the fibrillatory propensity of nonionic contrast media.

@entity1 @entity19611 @entity235 @entity1219 @entity1372 @entity1877 @entity2224 @entity1162 @entity3990 @entity413 @entity6111
Removing @entity1372 from standard ionic contrast media markedly increases the incidence of @entity2224 in @entity1 undergoing coronary angiography. Newer nonionic contrast media, @entity3990 , @entity6111 , and @entity19611 contain only trace amounts of @entity1372 . To determine whether @entity1372 attenuates or potentiates @entity2224 from nonionic contrast media, we measured the prolongation in QT interval and performed programmed electrical stimulation with one, two and three extra ventricular stimuli in 40 @entity235 during 4-mL intracoronary injections of @entity3990 , @entity6111 , and @entity19611 . Solutions of each contrast medium with added @entity1219 at concentrations of 0.225%, 0.45%, and 0.9% were compared with standard contrast media. The addition of @entity1219 markedly increased the amount of @entity1162 produced by each contrast medium. With @entity3990 , the amount of @entity1162 was 40 +/- 11 msec with standard @entity3990 , but was 58 +/- 11 msec with 0.225% @entity1219 / @entity3990 , 84 +/- 17 msec with 0.45% @entity1219 / @entity3990 , and 132 +/- 42 msec with 0.9% @entity1219 / @entity3990 (P less than .001). Similar results were seen with @entity6111 and @entity19611 . @entity2224 was difficult to induce with standard solutions of these agents (even with three extra stimuli), but became progressively easier to induce when @entity1219 was added. Three extra stimuli produced @entity2224 in zero of 11 @entity235 with standard @entity3990 , zero of 11 with 0.225% @entity1219 / @entity3990 , three of 11 with 0.45% @entity1219 / @entity3990 , and eight of 11 with 0.9% @entity1219 / @entity3990 (P less than .001). Similar results were observed with @entity6111 and @entity19611 . The addition of @entity1877 or @entity413 did not increase @entity2224 and @entity1162 . It is concluded that standard preparations of nonionic contrast media have a very low fibrillatory propensity.(ABSTRACT TRUNCATED AT 250 WORDS)
