[Regulation of natriuresis in XXXX ].

@entity1 @entity6708 @entity8 @entity6 @entity3486 @entity2316 @entity1372 @entity6478 @entity9208 @entity1723 @entity2915 @entity972 @entity1011 @entity1091 @entity7199
The aim of this study was to determine the influence of metabolic control of @entity6 on natriuresis, the effect of natriuretic peptides and renal @entity7199 on the kidney and the participation of proximal and distal tubules in natriuresis. The study was done in 41 individuals: 27 @entity1723 @entity1 and 14 healthy controls. The @entity1 were on insulin only, had normal blood pressure, and were prescribed a standard @entity6 diet without @entity1372 or protein restriction. @entity6 @entity1 were assigned to subgroups, depending on the stage of @entity8 and level of metabolic control. Urine collection was done three times daily in all @entity1 . The first collection was done after 500 mg @entity3486 (p.o.) and was followed by 10 mg amilorid (Midamor, Thomas Morson Pharmaceuticals). The third collection of urine was used to evaluate excretion of @entity6708 . In addition to @entity1372 , @entity1091 , @entity972 and @entity1011 clearances, excretion of renal @entity7199 , and levels of microalbuminuria, @entity9208 and glycated hemoglobin were also determined. @entity1091 clearance was used to evaluate tubular @entity1372 transport. The influence of diuretic peptides--ANP and urodilatin, on natriuresis was reflected by urinary @entity6708 excretion. Function of the @entity7199 -kinin system was studied on the basis of excretion of @entity7199 . Amilorid was used to test the effect of blocking @entity6478 -sensitive @entity1372 channels in distal tubules on natriuresis (Tab. 1). A statistically significant decrease in mean @entity1091 clearance was observed in @entity1723 @entity1 as compared to healthy controls. @entity1011 clearance was the same in both groups (Tab. 2). Lower @entity1091 clearance was observed in the subgroup of @entity6 @entity1 with "silent" @entity8 . @entity6 @entity1 with "silent" and early @entity8 had significantly higher levels of fractional @entity1372 reabsorption in the proximal tubule when compared with controls (Tab. 3). Moreover, lower daily excretion of @entity7199 was observed in @entity1 with stage II @entity8 in comparison to the control group (Tab. 4). Amilorid uptake had no influence on urinary @entity7199 . However, natriuresis after amilorid was significantly higher in @entity6 @entity1 than in controls. In conclusion, reabsorption in the proximal tubule is increased in @entity1 with "silent" @entity2316 , as revealed by decreased @entity1091 clearance and unchanged @entity1011 clearance. @entity2915 of the proximal tubule in stage II and III of @entity2316 results in increased @entity1372 reabsorption in the proximal tubule, as reflected by the increase in fractional @entity1372 reabsorption in this tubule. Amilorid, a distal tubule blocker, reduces distal tubule activity independently of urinary @entity7199 excretion. Elevated natriuresis was observed after amilorid without any change in urinary @entity7199 excretion.
