MicroRNA  -7 suppresses @entity1 XXXX invasion and proliferation by targeting the expression of @entity3818 .

@entity1 @entity1476 @entity5 @entity1600 @entity3818 @entity3 @entity1495 @entity12333 @entity694
UNASSIGNED: Previous studies have demonstrated that microRNA (miRNA) are essential in @entity5 development and invasion. The close association between @entity3818 ( @entity3818 ) and @entity694 ( @entity694 ) has been previously reported. miRNA  -7  ( @entity12333 ) inhibits the translation of @entity3818 protein. Therefore, the present study aimed to assess the underlying molecular mechanism of @entity12333 in @entity1 @entity694 cell lines, to provide a novel therapeutic biomarker of @entity694 in the future. The present study detected the expression of @entity12333  in  60  @entity694 tissues by reverse transcription  -quantitative polymerase chain reaction (RT  -qPCR). The association between the expression of @entity12333 and clinical pathological factors was analyzed. Overexpression/underexpression of @entity12333  were established by transfecting miR  -7mimics/inhibitors into HCT  -8 and Caco  -2  cells. The transfected @entity694 cell lines were used in cell viability and scratching assays. The regulation of @entity3818 by @entity12333 was analyzed by western blotting and RT  -qPCR. It was demonstrated that the expression of @entity12333 negatively correlated with @entity1600 and @entity5 node @entity3 staging in @entity694 (P<0.05). Inhibition of @entity12333 led to an accelerated ability of proliferation and migration in @entity694 cell lines. Additionally, overexpression of @entity12333 inhibited the proliferation and migration of @entity694 cells. In addition, it was also observed that @entity12333 regulated the proliferation and migration of @entity694 by regulating the protein expression of @entity3818 , therefore, regulating the expression of @entity1476 and @entity1495 . @entity12333 inhibited the proliferation and migration of @entity694 cells by regulating @entity3818 . These findings suggested that @entity12333 may be a novel therapeutic target for @entity694 .
