Delayed XXXX with favorable outcome in hypothermic-treated neonates with encephalopathy.

@entity1 @entity2806 @entity245 @entity1442 @entity204 @entity2332
OBJECTIVE: To determine whether @entity2332 modulates acquisition of sleep-wake cycling in term neonates with moderate to severe @entity2806 ( @entity2806 ) and the relationship to outcome. STUDY DESIGN: Twenty-nine term @entity1 with moderate to severe @entity2806 treated with selective head cooling were evaluated. All were monitored with amplitude-integrated electroencephalography during and video electroencephalography immediately after @entity2332 for >= 72 hours. Electroencephalograpic data were analyzed for background and sleep-wake cycling. Abnormal outcome included @entity204 or severe @entity245 >= 18 months. RESULTS: Acquisition of sleep-wake cycling was noted in nine @entity1 by 72 hours, in 13 by 96 hours, 19 by 120 hours, and 22 by 144 hours. Presence of sleep-wake cycling was associated with normal outcome, that is, 14 of 22 (64%), versus abnormal outcome, that is, none of seven without sleep-wake cycling (P = .006). The presence of sleep-wake cycling by 120 hours had a positive predictive value of 68% and negative predictive value of 90%. Magnetic resonance imaging abnormalities were related to @entity1442 . CONCLUSIONS: Although @entity1442 is markedly delayed in term neonates with moderate to severe @entity2806 treated with @entity2332 , approximately 65% with acquisition of cycling have a normal outcome. Sleep-wake cycling is an important additional tool for assessing recovery in term @entity1 with moderate to severe @entity2806 treated with @entity2332 .
