@entity412 /High-Density Lipoprotein XXXX Concentration Ratio Identifies Accentuated Cardio-Metabolic Risk.

@entity1 @entity6 @entity301 @entity412 @entity413 @entity165 @entity1851
PURPOSE: Plasma @entity412 /high-density lipoprotein @entity165 ratios (TG/HDL-C) have been shown to identify apparently healthy individuals at increased cardio-metabolic risk. This study evaluates the utility of this approach in @entity1 at risk of developing @entity6 . METHODS: Individuals (n=1010) in a private practice identified at increased risk of type 2 @entity6 (T2DM) by American Association of Clinical Endocrinologist criteria, were evaluated. Subjects had measurements of body mass index (BMI), blood pressure (BP), lipid/lipoprotein concentrations, highly sensitive @entity1851 (hs-CRP), and @entity413 , insulin and c-peptide concentrations during a 75gm, @entity413 challenge. The TG/HDL-C ratio was used to stratify individuals into high (highest quartile) vs. low (lowest 3 quartiles) risk categories. RESULTS: TG/HDL-C ratios identifying the highest quartile differed in @entity1 (>=  3.0) and @entity1 (>=  2.0). Using these cut-points, the high risk group for @entity1 and @entity1 had significantly higher BP, a more adverse lipid profile, was more insulin resistant as assessed by HOMA-IR, or the Matsuda index and had higher hs-CRP concentrations for @entity1 and @entity1 . Combined, approximately 25% of highest quartile @entity1 expressed values >=  3.0 mg/dL. CONCLUSION: The TG/HDL-C ratio provides a simple approach to identify individuals at accentuated cardio-metabolic risk within a population of perceived increased risk of T2DM. This was particularly the case as regards the presence of insulin resistance. Given the many syndromes associated with insulin resistance, including T2DM and @entity301 , an elevated TG/HDL-C ratio supports more aggressive efforts to enhance insulin sensitivity.
