Overexpression of the plasminogen activator inhibitor type-1 in XXXX .

@entity43 @entity1 @entity2289 @entity41 @entity5 @entity982 @entity3
BACKGROUND: The plasminogen activator-plasmin cascade plays a central role in the progression of @entity5 . The type-1 plasminogen activator inhibitor ( @entity2289 ) is the major physiological regulator of plasminogen activation. @entity2289 is suggested to play a crucial role in @entity5 cell invasion and @entity3 of various @entity5 . The aim of this study was to analyze the clinical and prognostic roles of @entity2289 in @entity43 (OC). MATERIALS AND METHODS: Expression analysis was conducted by immunohistochemistry and ELISA. Tissue sections of @entity982 -embedded @entity5 specimens and fresh-frozen @entity5 samples from @entity1 with benign and malignant @entity43 ( @entity43 ), who had undergone surgical intervention in the Department of Gynaecology and Obstetrics, Charit  , Germany, from 02/01 to 06/02, were used. Correlation analysis with conventional clinical factors, univariate and multivariate analyses were performed using SPSS (SPSS Inc., V.11.0). RESULTS: Sixty-five @entity1 (31 primary OC, 20 recurrent OC, 4 low-malignant potential @entity43 , 6 benign @entity43 , 4 normal ovary) were allocated to this trial. The median age was 57 years (range, 34-86) and the median follow-up was 20 months (range, 0-64). The distributions of (FIGO) @entity5 stage of all primary OC were: I = 16.1%, II = 3.2%, III = 45.2% and IV = 35.5%. @entity2289 was significantly overexpressed in the @entity5 epithelium of OC in comparison to the ovarian epithelium of benign @entity43 and normal ovary (p < 0.001). The median @entity2289 level was 1.92-fold higher in malignant @entity43 than in benign @entity43 . Statistical analyses showed no significant correlation between the expression of @entity2289 and clinical parameters. The expression of @entity2289 and the @entity2289 level, according to 3 different cut-off values, showed no prognostic impact in univariate analysis. In multivariate analysis, only @entity5 stage (FIGO) (p = 0.003) and @entity41 (p = 0.009) remained independent prognostic factors for post-operative survival. CONCLUSION: @entity2289 is significantly overexpressed in OC.
