Growth arrest specific protein 6/ XXXX signaling in @entity1 @entity8 .

@entity1 @entity32 @entity1310 @entity8 @entity14029 @entity26 @entity631 @entity1110 @entity1988 @entity1114 @entity9822 @entity27242 @entity35 @entity669
BACKGROUND: @entity27242 ( @entity27242 ) and its binding partner, the receptor @entity669 kinase @entity14029 , are important mediators in experimental @entity1310 . The authors tested whether the @entity27242 / @entity14029 signaling pathway participates in @entity1 @entity8 . METHODS: The authors compared 26 @entity1 renal specimens from @entity1 with @entity1310 , acute diffuse immune complex @entity631 , acute @entity1988 , antineutrophil cytoplasmic antibody--associated @entity631 , acute transplant rejection, and normal renal tissue. Because reactive @entity26 species are pivotal in @entity32 , the authors tested whether the @entity14029 / @entity27242 expression is influenced by @entity1110 oxidase in vitro. RESULTS: @entity27242 and @entity14029 immunofluorescence was barely detectable in normal kidney. However, in disease @entity14029 was copiously expressed in the small vessel media, glomeruli, distal tubules, and collecting ducts. Similarly, @entity27242 was upregulated in the small vessel intima and media, all segments of the renal tubules, the brush border, and glomeruli. @entity27242 and @entity14029 upregulation was a prominent but nonspecific finding in these @entity8 . Cultured @entity35 vascular smooth muscle cells and immortalized @entity1 mesangial cells were stimulated with angiotensin (Ang) II (1 x 10(-7) mol/L) for 6 or 18 hours. Confocal microscopy and Western blot showed Ang II-dependent @entity27242 and @entity14029 expression. An antisense probe against the @entity9822 phox unit of @entity1110 -oxidase suppressed Ang II-induced @entity27242 and @entity14029 expression. In addition, in @entity1114 phox knockout cells Ang II-induced @entity27242 and @entity14029 expression were blocked. CONCLUSION: @entity27242 / @entity14029 signaling is involved in @entity1 @entity8 . The Ang II-induced @entity27242 and @entity14029 expression may be dependent on @entity1110 -oxidase. @entity27242 and @entity14029 are important signaling molecules in @entity1 @entity8 and may be potential therapeutic targets.
