A novel schiff base @entity219 coordination compound inhibits proliferation and induces apoptosis of @entity1 XXXX cells.

@entity1 @entity589 @entity588 @entity5 @entity219 @entity421
Various kinds of schiff base metal complexes have been proven to induce apoptosis of @entity5 cells. However, it remains largely unknown whether schiff base @entity219 complexes induce apoptosis in @entity1 @entity5 cells. Here, we synthesized a novel schiff base @entity219 coordination compound (SBZCC) and investigated its effects on the growth, proliferation and apoptosis of @entity1 @entity421 MG-63 cells. A novel SBZCC was synthesized by chemical processes and used to treat MG-63 cells. The cell viability was determined by CCK-8 assay. The cell cycle progression, mitochondrial membrane potential and apoptotic cells were analyzed by flow cytometry. The apoptosis-related proteins levels were determined by immunoblotting. Treatment of MG-63 cells with SBZCC resulted in inhibition of cell proliferation and cell cycle arrest at G1 phase. Moreover, SBZCC significantly reduced the mitochondrial membrane potential and induced apoptosis, accompanied with increased @entity589 / @entity588 and FlasL/Fas expression as well as caspase-3/8/9 cleavage. Our results demonstrated that the synthesized novel SBZCC could inhibit the proliferation and induce apoptosis of MG-63 cells via activating both the mitochondrial and cell death receptor apoptosis pathways, suggesting that SBZCC is a promising agent for the development as anticancer drugs.
