@entity285 consumption and risk of @entity712 : the XXXX Risk in Communities Study.

@entity1 @entity731 @entity285 @entity712
AIM: @entity285 is a known cardiac toxin and heavy consumption can lead to @entity712 ( @entity712 ). However, the relationship between moderate @entity285 consumption and risk for @entity712 , in either @entity1 or @entity1 , remains unclear. METHODS AND RESULTS: We examined 14 629 @entity1 of the @entity731 Risk in Communities (ARIC) study (54    6 years, 55% @entity1 ) without prevalent @entity712 at baseline (1987-89) who were followed for 24    1 years. Self-reported @entity285 consumption was assessed as the number of drinks/week (1 drink = 14 g of @entity285 ) at baseline, and updated cumulative average @entity285 intake was calculated over 8.9    0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of @entity285 intake with incident @entity712 and assessed whether associations were modified by sex. Overall, most @entity1 were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting >= 7 to 14 drinks per week, and 3% reporting >= 14-21 and >= 21 drinks per week, respectively. Incident @entity712 occurred in 1271 @entity1 and 1237 @entity1 . @entity1 consuming up to 7 drinks/week had reduced risk of @entity712 relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in @entity1 (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of @entity712 was not significantly different from abstainers, either in @entity1 or in @entity1 . CONCLUSION: In the community, @entity285 consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future @entity712 , with a similar but less definite association in @entity1 than in @entity1 . These findings suggest that despite the dangers of heavy drinking, modest @entity285 consumption in early-middle age may be associated with a lower risk for @entity712 .
