Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in XXXX .

@entity35 @entity82 @entity4266 @entity299
Background. @entity299 often involve chronic pressure overload of the right ventricle (RV) which is a major cause of @entity4266 . Pulmonary artery (PA) banding has been used to produce animal models of @entity4266 . We have devised a new and easier method of constricting the PA and compared it directly with the partial ligation method. Methods. Eight-week-old male @entity35 (240-260   g) were divided into three groups: sham operation, partial pulmonary artery ligation (PAL) procedure, and pulmonary artery half-closed clip (PAC) procedure. RV function and remodeling were determined by echocardiography and histomorphometry. Results. Surgical mortality was significantly lower in the PAC group while echocardiography revealed significantly more signs of @entity4266 . At the 8th week after surgery RV @entity82 rate was significantly higher in the PAC group. Conclusions. This procedure of pulmonary artery banding in @entity35 is easier and more efficient than partial ligation.
