Protective Effects of XXXX and @entity6108 Separately against Thallium-Induced @entity137 in @entity35 .

@entity137 @entity66 @entity1865 @entity12971 @entity26 @entity5906 @entity409 @entity2041 @entity22770 @entity6108 @entity6172 @entity1234 @entity3929 @entity842 @entity880 @entity224 @entity35 @entity99 @entity73152 @entity130
@entity73152 (TI) is a cumulative poison intimately accompanied by an increase in reactive @entity26 species (ROS) formation that represents an important risk factor for tissue @entity130 . This study aims to determine the possible hepatoprotective and antioxidant effects of @entity12971 ( @entity22770 ) from garlic and @entity6108 from turmeric against TI-induced @entity99 and @entity66 ( @entity66 ) in @entity35 . This in vivo animal study divided @entity35 into six groups of 8 @entity35 per group. The first group received saline and served as the control group. The second and third groups received @entity22770 or @entity6108 only at a dose of 200 mg/kg. The fourth group received TI at a dose of 6.4 mg/kg for 5 consecutive days. The fifth and sixth groups received @entity22770 or @entity6108 orally 1 hour before TI intoxication at the same dose as the second and third groups. Liver integrity serum enzymes @entity5906 aminotransferase (AST), @entity3929 aminotransferase (ALT), alkaline phosphatase (ALP), @entity880 dehydrogenase (LDH), and y-glutamyltransferase (y-GT) were evaluated. Serum and liver tissue homogenate lipid peroxidation and @entity66 biomarkers were measured. The data were analyzed by one-way ANOVA followed by Duncan's multiple range test for post hoc analysis using SPSS version 16. TI induced marked oxidative @entity409 as shown by significantly (P <=0.05) elevated serum AST, ALT, ALP, LDH and y-GT levels. There were significant (P <=0.05) increases in serum and hepatic @entity1234 ( @entity1865 ) and serum @entity842 (NO) as well as decreased hepatic @entity2041 ( @entity6172 ) and catalase (CAT) activities. There were significantly (P <=0.05) less serum and hepatic @entity224 dismutase (SOD) and total antioxidant capacity (TAC). Pre-treatment with @entity22770 or @entity6108 ameliorated the changes in most studied biochemical parameters. @entity22770 and @entity6108 effectively reduced TI-induced liver @entity137 .
