Modifying Role of @entity4191 Polymorphism on the Association between Tea XXXX Exposure and the Brick-Tea Type @entity3296 .

@entity1 @entity17237 @entity3296 @entity3297 @entity4191 @entity36885 @entity1388 @entity1141
BACKGROUND: Brick tea type @entity3296 is a public health concern in the north-west area of China. The association between SNPs of genes influencing bone mass and @entity3296 has attracted attention, but the association of SNPs with the risk of brick-tea type of @entity3296 has not been reported. OBJECTIVE: To investigate the modifying roles of @entity4191 @entity36885 polymorphisms on this association. METHODS: A cross-sectional study was conducted. Brick-tea water was tested by the standard of GB1996-2005 (China). Urinary @entity1388 was tested by the standard of @entity3297 /T 89-2006 (China). @entity1141 was diagnosed by X-ray, the part we scheduled was forearm, @entity17237 , and pelvic, then diagnosed the @entity1141 by the standard of @entity3297 /192-2008 (China). Gene polymorphism was tested by Sequenom MassARRAY system. RESULT: The prevalence rate in different ethnical @entity1 was different: Tibetan individuals had the highest prevalence rate of @entity1141 . There were significant differences in genotype frequencies of @entity4191 Rs1695 among different ethnical @entity1 (p<0.001): Tibetan, Mongolian and Han subjects with homozygous wild type ( @entity4191 -AA) genotype were numerically higher than Kazakh and Russian subjects (p<0.001). Compared to Tibetan @entity1 who carried homozygous A allele of @entity4191 Rs1695, Tibetan @entity1 who carried G allele had a significantly decreased risk of @entity1141 (OR = 0.558 [95% CI, 0.326-0.955]). For Kazakh @entity1 , a decreased risk of @entity1141 among carriers of the G allele was limited to non high-loaded @entity1388 status (OR = 0. 166 [95% CI, 0.035-0.780] vs. OR = 1.478 [95% CI, 0.866-2.552] in @entity1 with high-loaded @entity1388 status). Neither SNP-IF nor SNP-age for @entity4191 Rs1695 was observed. CONCLUSION: The prevalence rate of the brick tea type @entity3296 might have ethnic difference. For Tibetan individuals, who had the highest prevalence rate, G allele of @entity4191 Rs1695 might be a protective factor for brick @entity1141 .
