Impact of excess gestational and post-weaning energy intake on vascular function of XXXX offspring.

@entity1707 @entity455 @entity409 @entity731
BACKGROUND: The development of long-term @entity455 can be linked to the intrauterine environment, and maternal nutrition during gestation plays a critical role in the future vascular health of offspring. The purpose of this investigation was to test the hypothesis that a high-energy (HE) gestational diet, HE post-weaning diet, or their combination will lead to @entity409 in offspring. METHODS: Duroc * Landrace gilts (n   =   16) were assigned to either a HE (10,144 Kcal/day, n   =   8) or normal energy (NE: 6721 Kcal/day, n   =   8) diet throughout pregnancy. Piglets were placed on either a NE or HE diet during the growth phase. At 3  months of age femoral arteries were harvested from offspring (n   =   47). Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively. RESULTS: BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring. However, no effect for the post-weaning diet on BK and SNP induced vasorelaxation was seen. This investigation demonstrates that a HE diet prenatally diminishes both BK and SNP induced vasorelaxation in @entity1707 . CONCLUSIONS: These findings suggest that a HE gestational diet can play a critical role in the development of offspring's vascular function, predisposing them to @entity409 . This dysfunction may lead to @entity731 development later in life.
