The role of XXXX in phospholipid analysis of tracheal and gastric aspirate in premature @entity1 .

@entity1 @entity3634 @entity8855
Tracheal and gastric aspirates from premature @entity1 simultaneously sampled shortly after birth were analyzed for their phospholipid composition using 2-dimensional thin layer chromatography. The results were related to clinical outcome. The L/S ratio was higher in @entity1 without than in @entity1 with @entity8855 ( @entity8855 ). The L/S values and the concentrations of @entity3634 (PG) were higher in tracheal compared with gastric aspirates (table I). This resulted in different L/S cutoff points with respect to lung maturity. In both aspirates, the predictive value of a "mature" (but not of an "immature") L/S ratio was improved by PG determination (table II). Only one out of 22 @entity1 with @entity8855 had a completely "mature" phospholipid profile in its tracheal aspirate. Two vaginally delivered premature @entity1 without @entity8855 had an "immature" phospholipid pattern in their gastric aspirates, but a "mature" one in their tracheal aspirates. The results indicate that phospholipid analysis of tracheal and gastric aspirates shortly after birth is useful in the biochemical diagnosis of @entity8855 if proper cutoff points for the L/S ratio are used and the determination of PG is included. It may prove to be important in establishing criteria for a therapeutic trial of surfactant substitution.
