XXXX uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.

@entity1 @entity43985 @entity19 @entity3965 @entity281 @entity501 @entity311 @entity31365
Erythrocyte invasion by @entity311 parasites is a complex multistep process involving parasite and erythrocyte receptors. It is a critical stage in the parasite life cycle and, therefore, a logical step in which to intervene to prevent or ameliorate disease. Rodent models of @entity311 , commonly @entity501 , are frequently used for studies of @entity311 pathogenesis. Little is known, however, about the invasion machinery of rodent @entity311 parasites. We have found previously that @entity19 congenic for a region of chromosome 1, containing the @entity43985 ( @entity43985 ), have different susceptibility to @entity501 @entity281 . Because @entity3965 , a @entity1 parasite, and @entity31365 , a simian parasite, use @entity43985 to enter @entity1 erythrocytes, we sought to identify the role of the @entity19 @entity43985 in @entity501 invasion. Using a novel in vivo invasion assay and @entity43985 knock-out @entity19 , we found that @entity43985 knock-out normocytes (mature erythrocytes) had negligible levels of @entity501 invasion compared with wild-type normocytes, demonstrating that @entity43985 is a receptor for invasion of @entity19 erythrocytes. In contrast, @entity43985 knock-out reticulocytes were invaded at a rate similar to that for wild-type reticulocytes. We conclude that there is a @entity43985 - independent pathway for reticulocyte invasion. These findings represent the first identification of a @entity19 @entity311 receptor on erythrocytes and the first determination that different pathways of invasion exist on normocytes and reticulocytes. Because we show conservation of host-receptor interactions between rodent and @entity1 @entity311 , we can now use this model to identify how immunity can interfere with the invasion process.
