Association between renin-angiotensin- XXXX system-related genes and blood pressure in a Korean population.

@entity72589 @entity3920 @entity6330 @entity1369 @entity101 @entity1289 @entity72586 @entity2178 @entity1372 @entity72587 @entity15505 @entity916 @entity7743 @entity23229 @entity72588
AIMS. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential @entity101 . Because the renin-angiotensin- @entity1369 system (RAAS) has a key role in vasoconstriction, vasodilation, and @entity1372 and electrolyte balance, it is central in blood pressure control and so is an appropriate target in @entity101 treatments. The present study assessed the association of RAAS-related genes with blood pressure and @entity101 in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes ( @entity2178 , @entity916 , @entity1289 , @entity15505 , @entity7743 , @entity6330 , @entity23229 , @entity72586 , and @entity3920 ) were assessed for their correlation with blood pressure and @entity101 using genotype data of 8842 individuals from the Korea Association Resource subject pool. MAJOR FINDINGS. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes ( @entity1289 , @entity15505 , @entity6330 , @entity23229 , @entity72586 , and @entity3920 ). An additional @entity101 case-control study identified 10 SNPs in @entity23229 and @entity1289 that were linked to @entity101 . PRINCIPAL CONCLUSION. Three SNPs ( @entity72587 , @entity72588 , and @entity72589 ) in @entity23229 correlate with both blood pressure and @entity101 . Genetic polymorphisms in RAAS-related genes appear to be associated with @entity101 in a Korean population.
