Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, XXXX .

@entity35 @entity3522
The effects of various i.v. doses of @entity3522 (Voltaren, 1.5, 3, 6 and 9 mg/kg) were evaluated by measuring the vocalization threshold in response to paw pressure in normal and in Freund's adjuvant-induced arthritic @entity35 . An electrophysiological study performed in parallel in arthritic @entity35 considered the effects of 6 mg/kg i.v. @entity3522 on ventrobasal thalamic neuronal responses driven by mild stimulation of an inflamed joint. In normal @entity35 , 6 and 9 mg/kg i.v. @entity3522 raised vocalization thresholds significantly (maximum vocalization thresholds were respectively 135.67 +/- 3.30% and 157.41 +/- 4.62% of the preinjection control at 30 min, n = 9 in each group), while no effect was observed with 3 mg/kg. In arthritic @entity35 , i.v. doses of 3, 6 and 9 mg/kg @entity3522 induced a clear analgesic effect (maximum vocalization thresholds were respectively 172.22 +/- 4.26, 201.78 +/- 4.76, 222.33 +/- 5.10% of the control at 25 min, n = 9 in each group), whereas a dose of 1.5 mg/kg i.v. did not raise the threshold. In arthritic @entity35 , the VB neuronal responses were depressed by about 50% 20 min after an injection of 6 mg/kg i.v. @entity3522 . These results clearly establish that @entity3522 produces a dose-dependent analgesic effect, which is more potent in arthritic than in normal @entity35 .
