Antidepressant use in @entity195 XXXX : results of the REAL.FR cohort.

@entity1 @entity308 @entity146 @entity2146 @entity716 @entity195
BACKGROUND: Psychotropic medication is widely prescribed in clinical practice for the management of @entity146 ( @entity146 ) in @entity195 ( @entity195 ). However, there have been few pharmaco-epidemiological studies or studies conducted in a natural setting on the real use of antidepressants in @entity195 . The aim of this survey was to assess the prevalence of antidepressant use in @entity195 and to identify the clinical factors associated with antidepressant prescription. METHODS: REAL.FR is a four-year, prospective, multi-center study. Baseline data including demographic characteristics, clinical variables and drug intake were obtained. @entity308 were determined using the Neuropsychiatric Inventory (NPI). RESULTS: A total of 686 @entity195 @entity1 were included. Antidepressant treatment was prescribed for 34.8% of @entity1 . Clinically significant @entity308 (NPI >or= 4) were observed in 20.5% of the total population. Although @entity308 subjects were significantly more likely to be treated with antidepressants than non- @entity308 subjects (p<0.0001), only 60% of @entity308 subjects overall were prescribed an antidepressant. In multivariate analysis, clinically significant @entity308 were associated with antidepressant prescription although this result was only observed in subjects without a previous history of @entity308 . CONCLUSIONS: The available data on antidepressant efficacy in @entity146 other than @entity308 (in particular, @entity2146 , @entity146 and, occasionally, @entity716 ) do not influence prescription choices. @entity308 may be taken more seriously in the absence of a previous history of @entity308 , leading to increased antidepressant prescription rates in individuals presenting with @entity308 for the first time.
