@entity73 in XXXX : More than a Frontostriatal Dysfunction.

@entity1 @entity73 @entity409 @entity191 @entity1726 @entity2414
@entity73 in @entity191 has been traditionally considered as being mainly related to @entity409 secondary to frontostriatal affectation. However, this traditional consideration has recently been challenged. Forty-three nondemented @entity1726 @entity1 (mean age = 59.19; SD = 9.64) and twenty control group subjects (mean age = 60.85; SD = 12.26) were studied. They were assessed on a wide range of cognitive functions. @entity1 showed motor slowing (p = .012), along with alterations in visuoperceptive (p = .001), visuospatial (p = .007) and visuoconstructive functions (p = .017), as well as in visual span (direct: p = .008; inverse: p = .037). Regarding executive functions, differences were not observed in classical measures for verbal fluency (phonetic: p = .28; semantic: p = .27) or in response inhibition (Stroop test: p = .30), while execution was altered in other prefrontal tasks (Wisconsin Test: p = .003; action fluency: p = .039). @entity1 showed altered performance in verbal learning processes (p = .005) and delayed memory (free: p = .032; cued: p = .006), visuospatial learning (p = .016) and linguistic functions (naming: p < .001; comprehension: p = .007). Poor performance in visuospatial memory is predicted by @entity2414 . Taken together, the observed alterations not only suggest prefrontal affectation, but also temporal and parietal systems impairment. Thus, @entity73 in nondemented @entity1726 @entity1 cannot be exclusively explained by frontostriatal circuit affectation and the resulting @entity409 .
