XXXX contributes to apathy and disinhibition in @entity146 .

@entity1 @entity146 @entity747 @entity1315 @entity62
OBJECTIVE: To relate changes in fractional anisotropy associated with @entity146 to measures of apathy and disinhibition. BACKGROUND: Apathy and disinhibition are the 2 most common behavioral features of @entity146 , and these symptoms are associated with accelerated @entity1 decline and caregiver stress. However, little is known about how @entity62 contributes to these symptoms. METHODS: We collected neuropsychiatric data, volumetric magnetic resonance imaging, and diffusion-weighted imaging in 11 @entity1 who met published criteria for @entity146 and had an autopsy-validated cerebrospinal fluid profile consistent with @entity747 . We also collected imaging data on 34 healthy seniors for analyses defining regions of disease in the @entity1 . We calculated and analyzed fractional anisotropy with a white matter tract-specific method. This approach uses anatomically guided data reduction to increase sensitivity, and localizes results within canonically defined tracts. We used nonparametric, cluster-based statistical analysis to relate fractional anisotropy to neuropsychiatric measures of apathy and disinhibition. RESULTS: The @entity1 with @entity146 had widespread reductions in fractional anisotropy in anterior portions of frontal and temporal white matter, compared to the controls. Fractional anisotropy correlated with @entity1315 in the right corona radiata. CONCLUSIONS: In @entity1 with @entity146 , apathy and disinhibition are associated with distinct regions of @entity62 . The implicated fiber tracts likely support frontotemporal networks that are involved in goal-directed behavior.
