The response of the intestinal epithelium in B10.A XXXX to infection with @entity8416 .

@entity2199 @entity8416 @entity19 @entity1373 @entity665 @entity8573 @entity194
Previous studies on intestinal @entity8573 have dealt mainly with areas other than the intestinal epithelium. Since the epithelium is now known to be the parasite's habitat, its response to infection is important. Infection with @entity8416 in immunologically slow-responding B10.A @entity19 was associated with crypt @entity1373 and @entity194 . With similar infection levels in both primary and challenge infections, there was no difference in the maximal degree of @entity194 or @entity1373 between the 2 groups. However, challenged @entity19 underwent these mucosal changes in about half the time. Expulsion of worms always occurred during regeneration of the intestinal epithelium suggesting that the host's defense mechanism of altering the kinetics of the epithelium was not the prime factor causing expulsion. Pulse labelling of enterocytes with @entity665 showed that there was no significant increase in the relative size of the proliferation zone. This indicates that the crypt cell output was not altered by this parasite. Atrophy of the villus was analysed with respect to its 3-dimensional shape. There was a decrease in both height and width of the villus but not thickness. Thus, there is a real decrease in the size of the enterocyte population per villus. Histochemical staining of the enterocyte brush border by an alkaline phosphatase method showed that (1) hyperplastic crypts have an enlarged maturation zone and (2) the villus epithelium is composed entirely of mature cells. The distribution of the @entity2199 population was compared to these changes in the intestine. @entity8416 showed a marked anteriad (distal to proximal) migration prior to expulsion. Thus, utilizing a novel approach to study intestinal @entity8573 , the response of the mucosal epithelium has been characterized.
