Noninvasive assessment of microvascular function in arterial XXXX by transthoracic Doppler harmonic echocardiography.

@entity1 @entity662 @entity859 @entity66 @entity101 @entity301 @entity409 @entity450 @entity3979
OBJECTIVES: The present study sought to investigate the use of transthoracic Doppler harmonic echocardiography (TTDHE) to evaluate changes in coronary flow dynamics due to @entity409 . BACKGROUND: Coronary flow velocity reserve (CFVR) measurements by TTDHE are useful for assessing @entity3979 . It remains unclear, however, if @entity66 can be detected. METHODS: In 54 @entity1 with @entity662 , intracoronary Doppler (ICD) and TTDHE were used to measure average peak velocity at baseline and @entity450 . Significant @entity301 had been ruled out by both angiography and intravascular ultrasound. Comparative measurements were performed in the distal left anterior descending coronary artery after intracoronary and intravenous administration of @entity859 , and CFVR was calculated. @entity101 @entity1 (n = 25) were studied and compared to a control group (26 normotensive individuals). RESULTS: Three @entity1 (5%) had to be excluded because of insufficient image quality or side effects. In both groups, TTDHE-derived CFVR data correlated closely with ICD measurements (group 1: y = 0.67x + 0.076, standard error of estimate [SEE] = 0.25, r = 0.87, p < 0.001; group 2: y = 0.64x + 1.11, SEE = 0.26, r = 0.87, p < 0.001). CFVR was lower in @entity101 than in normotensive controls (2.44 +/- 0.49 vs. 3.33 +/- 0.40, p < 0.001, cut point = 2.84). CONCLUSIONS: The newly described echocardiographic method is suitable for assessing @entity409 noninvasively and corresponds well to invasive measurements.
