[Effects of Kaixin San formulas on behavioristics and central monoamine neurotransmitters of chronic stress XXXX ].

@entity35 @entity969 @entity308 @entity750
The efficacy of Chinese herbal formula in treating @entity308 has been proved in many studies. In this study, six different Kaixin San formulas were compared to investigate their effects on central monoamine neurotransmitters of chronic stress @entity35 and against @entity308 based on their different components in plasma, in order to discuss the efficacy-comparability relationship and the possible efficacy mechanism. The classic isolation method and the chronic unpredictable mild stress (CUMS) @entity308 model were combined to investigate the changes in contents in hippocampus and monoamine neurotransmitters (NE, DA, @entity750 ) and the components of some formulas in plasma with HPLC and UPLC-Q-TOF-MSE methods. As a result, Dingzhi Xiaowan recorded in Essential Recipes for Emergent Use Worth A Thousand significantly increased the behavioral scores, NE and @entity750 contents in hippocampus and NE, DA and @entity750 contents in cortex, with the best anti-depressant effect. Dingzhi Xiaowan recorded in Complete Records of Ancient and Modern Medical Works showed a notable increase in @entity969 preference and open field score in model @entity35 , NE content in hippocampus and NE, DA and @entity750 contents in cortex, with a certain anti anti-depressant effect. Kaixin San recorded in Ishinpo showed remarkable rise in weight of model @entity35 . NE content in hippocampus and DA content in cortex. Puxin Decoction recorded in A Supplement to Recipes Worth A Thousand Gold showed @entity750 content in hippocampus and DA content in cortex. Kaixin San recorded in Yimenfang only showed DA content in cortex. Kaixin Wan recorded in Essential Recipes for Emergent Use Worth A Thousand did not mention the antidepressant effect. According to the results, the formulas' different anti-depressant effects may be related to the different plasma components.
