Incidence of Pituitary Apoplexy and Its Risk Factors in Chinese @entity1 : A Database Study of @entity1 with XXXX .

@entity1 @entity227 @entity5 @entity542 @entity2894 @entity391 @entity4611 @entity1939 @entity977 @entity892 @entity1736 @entity10 @entity221 @entity21696
BACKGROUND: There are few studies of the incidence and clinical characteristics of @entity2894 ( @entity2894 ) in @entity977 @entity1 , and the findings have been inconsistent. OBJECTIVE: The aim of the study was to retrospectively assess the incidence, clinical presentation, surgical management and postoperative complications of @entity2894 in @entity977 @entity1 . METHODS: A database was specifically designed to collect clinical, therapeutic, prognostic and histological information about @entity977 @entity1 . Using multivariate logistic regression, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to identify associated factors. RESULTS: A total of 2021 @entity977 @entity1 were recruited. 97 (4.8%) @entity1 had @entity2894 . The incidence of @entity2894 was 10.11% in @entity1 with @entity4611 , and 0.36% in @entity1 with microadenoma. Variables for the logistic regression model independently associated with @entity2894 were sex (male vs. female, OR = 2.54, 95% CI: 1.59~4.07), @entity5 type (negative staining vs. positive staining, OR = 2.04, 95% CI: 1.29~3.23), and @entity5 size (macroadenoma vs. microadenoma, OR = 26.46, 95% CI = 9.66~72.46). @entity227 were the most common symptoms in @entity1 with @entity977 . @entity1 with and without @entity2894 had similar frequency of @entity227 , @entity542 , acromegalic appearance, @entity21696 , cold intolerance and Cushingoid appearance, but @entity10 , @entity391 , @entity1736 , @entity892 , @entity221 and @entity1939 were significantly more common in @entity1 with @entity2894 . Pearson Chi-Square tests revealed a significant difference in surgical approach between @entity1 with and without @entity2894 (95.88% vs. 85.57%, P = 0.01). CONCLUSION: Our findings suggest that @entity2894 is not a rare event. Male sex, @entity5 , and macroadenoma are associated with an increased risk of @entity2894 . Compared with @entity977 @entity1 without @entity2894 , @entity1 with @entity2894 have more severe symptoms.
