Risk factors for advanced @entity694 and XXXX in asymptomatic individuals.

@entity1 @entity5493 @entity1127 @entity5 @entity167 @entity165 @entity14 @entity3 @entity460 @entity652 @entity694 @entity1141 @entity560
CONTEXT: Knowledge of risk factors for @entity14 could inform risk reduction strategies for asymptomatic individuals. Few studies have evaluated risk factors for advanced @entity14 in asymptomatic individuals, compared risk factors between @entity1 with and without @entity1127 , or included most purported risk factors in a multivariate analysis. OBJECTIVE: To determine risk factors associated with advanced @entity14 in a cohort of asymptomatic @entity1 with complete colonoscopy. DESIGN, SETTING, AND @entity1 : Prospective, cross-sectional study of 3121 asymptomatic @entity1 aged 50 to 75 years from 13 Veterans Affairs medical centers conducted between February 1994 and January 1997. All @entity1 had complete colonoscopy to determine the prevalence of advanced @entity5 , defined as an @entity652 that was 10 mm or more in diameter, a @entity5493 , an @entity652 with high-grade @entity1141 , or @entity3 . Variables examined included history of first-degree relative with @entity14 , prior cholecystectomy, serum @entity165 level, physical activity, smoking, @entity167 use, and dietary factors. MAIN OUTCOME MEASURES: An age-adjusted analysis was performed for each variable to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) associated with having advanced @entity5 compared with having no @entity1127 . We developed a multivariate logistic regression model to identify the most informative risk factors. A secondary analysis examined risk factors for having @entity1127 compared with having no @entity1127 and compared with having advanced @entity5 . RESULTS: Three hundred twenty-nine @entity1 had advanced @entity5 and 1441 had no @entity1127 . In multivariate analyses, we found positive associations for history of a first-degree relative with @entity14 (OR, 1.66; 95% CI, 1.16-2.35), current smoking (OR, 1.85; 95% CI, 1.33-2.58), and current moderate to heavy @entity167 use (OR, 1.02; 95% CI, 1.01-1.03). Inverse associations were found for cereal fiber intake (OR, 0.95; 95% CI, 0.91-0.99), @entity560 intake (OR, 0.94; 95% CI, 0.90-0.99), and use of nonsteroidal anti-inflammatory drugs (NSAIDs) (OR, 0.66; 95% CI, 0.48-0.91). In the univariate analysis, the inverse association was found with cereal fiber intake greater than 4.2 g/d, @entity560 intake greater than 645 IU/d, and daily use of NSAIDs. Marginal factors included physical activity, daily multivitamin use, and intake of @entity460 and fat derived from red meat. No association was found for body mass index, prior cholecystectomy, or serum @entity165 level. Three hundred ninety-one @entity1 had @entity1127 as the worst lesion found at colonoscopy. Risk variables were similar to those for @entity1 with no @entity1127 , except that past and current smoking were associated with an increased risk of @entity1127 . CONCLUSIONS: Our data endorse several important risk factors for advanced @entity694 and provide a rationale for prudent risk reduction strategies. Further study is needed to determine if lifestyle changes can moderate the risk of @entity14 .
