Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during XXXX .

@entity1 @entity1717 @entity5 @entity4053
@entity4053 results in a reduction in cardiac baroreflex sensitivity and a shift in the baroreflex working range to higher heart rates. This effect is mediated, in part, by the carotid chemoreceptors. Therefore, we hypothesized @entity4053 -mediated changes in baroreflex control of heart rate would be blunted in carotid body-resected @entity1 when compared with healthy controls. Five @entity1 with bilateral carotid body resection for @entity5 and 10 healthy controls completed a 180-minute @entity1717 , hypoglycemic (   3.3 mmol/L) clamp. Changes in heart rate, blood pressure, and spontaneous cardiac baroreflex sensitivity were assessed. Baseline baroreflex sensitivity was not different between groups (P>0.05). @entity4053 resulted in a reduction in baroreflex sensitivity in both the groups (main effect of time, P<0.01) and responses were lower in resected @entity1 when compared with controls (main effect of group, P<0.05). @entity4053 resulted in large reductions in systolic (-17  7 mm Hg) and mean (-14  5 mm Hg) blood pressure in resected @entity1 that were not observed in controls (interaction of group and time, P<0.05). Despite lower blood pressures, increases in heart rate with @entity4053 were blunted in resected @entity1 (interaction of group and time, P<0.01). Major novel findings from this study demonstrate that intact carotid chemoreceptors are essential for increasing heart rate and maintaining arterial blood pressure during @entity4053 in @entity1 . These data support a contribution of the carotid chemoreceptors to blood pressure control and highlight the potential widespread effects of carotid body resection in @entity1 .
