Predictors of Plaque Rupture Within Nonculprit @entity1856 in XXXX With Acute Coronary Syndromes: The PROSPECT Study.

@entity1 @entity1187 @entity397 @entity460 @entity1856
OBJECTIVES: The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting @entity397 within nonculprit @entity1856 ( @entity1856 ) in @entity1 with @entity1187 . BACKGROUND: Previous studies have demonstrated that @entity397 is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. METHODS: In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 @entity1 with @entity1187 . Untreated nonculprit lesion @entity1856 were classified as proximal (<20  mm), mid (20 to 40 mm), and distal (>40 mm) according to the distance from the ostium to the maximum necrotic core  site. RESULTS: Overall, 74 ruptured @entity1856 and 2,396 nonruptured @entity1856 were identified in nonculprit vessels. The majority of @entity1856 (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p  < 0.001). In a multivariate logistic regression model, independent predictors for  @entity397 included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95%  confidence interval [CI]: 0.76 to 0.98; p  = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to  2.58; p  <  0.0001), vessel area per mm(2) (OR: 1.14; 95% CI: 1.11 to 1.17; p  < 0.0001), @entity460 (OR: 0.09; 95% CI: 0.05 to 0.18; p  <  0.0001), and  right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p  = 0.006). By receiver-operating characteristic analysis, vessel area correlated with @entity397 stronger than either plaque burden (p  <  0.001) or location (p  < 0.001). CONCLUSIONS: Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of @entity460 were associated with @entity397 . The present study suggests that among these variables, vessel area may be the strongest predictor of @entity397 among non-left main coronary arteries. ( PROSPECT: An Imaging Study in @entity1 With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466).
