The Effect of Donor-Dependent Administration of XXXX Umbilical Cord Blood-Derived Mesenchymal Stem Cells following Focal Cerebral Ischemia in @entity35 .

@entity1 @entity64 @entity63 @entity2435 @entity35 @entity385
@entity64 is an @entity63 caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a @entity2435 (tPA). However, this therapy is limited by temporal constraints. Recently, several studies have focused on cell therapy as an alternative treatment. Most researches have used fixed donor cell administration, and hence, the effect of donor-dependent cell administration is unknown. In this study, we administered 3 types of donor-derived @entity1 umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in the @entity63 boundary zone of the @entity385 @entity35 model. We then performed functional and pathological characterization using rotarod, the limb placement test, and immunofluorescent staining. We observed a significant decrease in neuron number, and notable @entity64 -like motor dysfunction, as assessed by the rotarod test (~40% decrease in time) and the limb placement test (4.5 point increase) in control @entity35 with @entity385 . The neurobehavioral performance of the @entity35 with @entity385 that were treated with hUCB-MSCs was significantly better than that of @entity35 in the vehicle-injected control group. Regardless of which donor cells were used, hUCB-MSC transplantation resulted in an accumulation of neuronal progenitor cells, and angiogenic and tissue repair factors in the @entity63 boundary zone. The neurogenic and angiogenic profiles of the 3 types of hUCB-MSCs were very similar. Our results suggest that intraparenchymal administration of hUCB-MSCs results in significant therapeutic effects in the @entity63 brain regardless of the type of donor.
