[Association between single nucleotide polymorphisms (SNPs) at the promoter of @entity1254 gene and essential XXXX in Chinese Korean and Han of Yanbian region].

@entity1 @entity67613 @entity72775 @entity101 @entity17211 @entity67614 @entity42884 @entity26056 @entity72777 @entity70206 @entity72776 @entity1254 @entity72778 @entity412 @entity413 @entity72774 @entity165
To investigate the association between the single nucleotide polymorphisms (SNPs) in @entity1254 gene promoter and essential @entity101 (EH) in Chinese Korean and Han of Yanbian area, 220 EH @entity1 and 268 normotensive control individuals were enrolled. PCR and direct DNA sequencing were used to determine the @entity67613 ( @entity67614 ), @entity70206 ( @entity26056 ), @entity42884 ( @entity72774 ), @entity72775 ( @entity72776 ), and @entity72777 ( @entity72778 ) SNPs in the promoter region of @entity1254 gene. Total @entity165 (TC), the @entity412 (TG), fasting plasma @entity413 (FPG), low density lipoprotein- @entity165 (LDL-C), and high density lipoprotein- @entity165 (HDL-C) levels were examined by oxi-dase method. The plasma @entity1254 and insulin were measured by enzyme linked immunosorbent assay (ELISA). The results showed that: (1) SNPs of @entity67613 , @entity42884 , and @entity72775 were found and in Hardy-Weinberg equilib-rium (P>0.05), but not the case in @entity70206 and @entity72777 . (2) @entity67613 and @entity72775 were perfectly in link-age disequilibrium (D'=1; r2=1). (3) The allele G frequency of @entity67613 polymorphism in Chinese Korean (21.10%) was significantly higher than that in Chinese Han (12.50%), and also higher in EH group than in the control group of Chinese Han. The genotype and allele frequencies of @entity42884 showed no significant difference between the two groups ob-served. (4) The haplotype -11426G -11377C frequency in EH of Chinese Han was higher than in the control group (P<0.05). (5) The EH showed lower plasma @entity1254 level compared with the control group (P<0.001) in both Chinese Korean and Han. Our results indicate that: (1) the perfect linkage disequilibrium of @entity67613 and @entity72775 is first reported, and the SNP of @entity67613 is associated with Chinese Han and Korean. (2) -11426 G and -11426G -11377C are risk factor and risk haplotype in Yanbian Chinese Han, but not in Chinese-Korean. (3) The @entity17211 is the important risk factors for EH in Chinese Korean and Han of Yanbian area. (4) There is no relationship between @entity67613 polymorphism and the plasma @entity1254 level.
