The 1993 ISOBM Abbott Award Lecture. Isozymes, XXXX markers and oncodevelopmental biology.

@entity172 @entity1 @entity263 @entity5 @entity2 @entity4797 @entity623 @entity15766 @entity3800
This is the history of discoveries of several enzyme @entity5 markers in the awardees laboratory. The first, beta-glucuronidase, was originally related to the physiological actions of @entity172 and @entity3800 . Perfection of histochemical techniques based on new substrates demonstrated the dual localization of beta-glucuronidase in endoplasmic reticulum and lysosomes. Tumor tissues, in general, are enriched with beta-glucuronidase. Next, acid phosphatase of the prostate gland possesses the distinctive property of undergoing inhibition by @entity15766 . This organ-specific inhibitor was incorporated into the Fishman-Lerner method for measuring serum acid phosphatase of prostatic origin. This significantly increased the specificity of the measurement of serum acid phosphatase for @entity263 . Finally, the discovery of the Regan Isoenzyme, @entity623 ( @entity623 ) in a @entity1 with disseminated @entity2 provided a @entity5 marker useful in the management of @entity5 , in particular. Closely related to @entity623 is germ cell alkaline phosphatase which is eutopically expressed in @entity4797 . Finally, radioimmunolocalization and radioimmunotherapy of @entity623 in these @entity5 have been achieved by others.
