Increased urinary neutrophil gelatinase associated lipocalin in XXXX and leukocyturia.

@entity1 @entity4658 @entity633 @entity810 @entity15901 @entity293
BACKGROUND: Neutrophil gelatinase associated lipocalin ( @entity15901 ) is a protein present in neutrophils. @entity15901 is a promising biomarker for @entity810 . In @entity293 , urinary neutrophils can be a potential source of urinary @entity15901 . We investigated the effects of @entity293 and urinary neutrophil counts on urinary @entity15901 values. METHODS: @entity15901 was assayed using an immunoassay (ARCHITECT). Urine flowcytometry was performed with the UF-1000i (Sysmex). RESULTS: A correlation between the urinary white blood cell (WBC) count and @entity15901 concentrations was observed: log(Y) ( @entity15901 ,  g/L)=1.284+0.439 log(X) (urinary WBC, 10(9) cells/L); r=0.518. Similarly, the bacterial count correlated weakly with @entity15901 ( @entity15901 ,  g/L)=1.796+0.124 log(X) (bacterial count, 10(9) cells/L); r=0.243. @entity633 correlated moderately with @entity15901 values: log(Y) ( @entity15901 ,  g/L)=1.557+0.339 log(X) ( @entity633 , mg/L); r=0.368; a(1)-microglobulin (a1M) correlated weakly with @entity15901 ( @entity15901 ,  g/L)=1.631+0.360 log(X) (a1M, mg/L); r=0.381. CONCLUSIONS: Leukocyte contributions to urinary @entity15901 concentrations can be important. In leukocyturia or tubular damage (e.g., intensive care @entity1 ), using a fixed cut-off value for interpreting urinary @entity15901 data can lead to false positive results. Therefore, we suggest a mathematical correction in cases with @entity4658 (>100*10(9) cells/L) and urinary @entity15901 concentration >100  g/L: corrected @entity15901 ( g/L)= @entity15901 -0.12 (urinary WBC, 10(9) cells/L).
