Antinociceptive and Anti-Inflammatory Activities of Teucrium persicum Boiss. Extract in XXXX .

@entity2708 @entity738 @entity19 @entity3522 @entity406 @entity2645 @entity1286 @entity1930 @entity1118 @entity9
UNASSIGNED: Background. Therapeutic properties of Teucrium species as antioxidant, antibacterial, analgesic, anticancer, diuretic, and tonic compounds have been proved earlier. Materials and Methods. In this study, the antinociceptive and anti-inflammatory effects of the aqueous extract of Teucrium persicum on @entity1118 , @entity1930 as a model of @entity9 , and inflammatory models were investigated by @entity406 , hot-plate, and @entity2708 pellet-induced @entity738 models in @entity19 , respectively. T. persicum aqueous extracts (100, 200, and 400   mg/kg) were orally gavaged for one week. On 8th day, the time spent and the number of lickings were recorded in @entity406 test. @entity1286 and @entity3522 were used intraperitoneally as positive controls. In sciatic nerve ligated animals, as a model of @entity9 , doses (100, 200, and 400   mg/kg) of T. persicum extract (TPE) were orally gavaged for 14 consecutive days. The analgesic effect of this extract was examined 14 days after @entity1930 using the hot-plate test. Controls received saline and @entity2645 (40   mg/kg, i.p.) was used a positive control for @entity9 model. Results. In the @entity406 test, a week oral gavage of all TPE doses (100, 200, and 400   mg/kg) caused a significant decrease on the licking response compared to the control negative animals. In the hot-plate test, doses of 200 and 400   mg/kg showed significant analgesic effects in sciatic nerve ligated animals. Oral gavaged of TPE revealed significant analgesic effect on @entity1118 in both @entity406 test and sciatic nerve ligated animals. The TPEs did not have any significant anti-inflammatory effects in @entity2708 pellet-induced @entity738 formation in @entity19 . Conclusions. These results suggest that the aqueous extract from T. persicum Boiss. produced antinociceptive effects. Its exact mechanism of action still remains indistinct.
