Effect of lifestyle weight loss intervention on disease severity in @entity1 with XXXX : a systematic review and meta-analysis.

@entity1 @entity23 @entity1569 @entity28
BACKGROUND: Psoriasis is a chronic inflammatory disease of the skin with joint manifestations. Greater @entity1569 severity and lower response to treatment have been linked to @entity28 . However, the effect of weight reduction by non-pharmacologic intervention on disease severity is still questionable. This is a systematic review and meta-analysis of @entity23 ( @entity23 ) on the effect of dietary and lifestyle weight loss interventions on @entity1569 severity. METHODS: We comprehensively searched PubMed/MEDLINE, EMBASE and CENTRAL from their inception to August 2014. Inclusion criteria were @entity23 that examined lifestyle intervention by diet or exercise in overweight or @entity28 @entity1 with @entity1569 and measured the severity of @entity1569 as an outcome compared with controls. Two authors independently assessed article quality and extracted the data. RESULTS: Out of 12 full-text articles, 7 @entity23 involving 878 @entity1 met our inclusion criteria. Five of these @entity23 were included in the meta-analysis, which was based on the random-effects model. There was a greater reduction in the Psoriasis Area Severity Index (PASI) score in @entity1 receiving weight loss intervention than in controls, with a pooled mean difference of -2.49 (95% confidence interval (CI), -3.90 to -1.08; P=0.004). More @entity1 in the intervention group than in the control group achieved a 75% reduction in the PASI score, with a pooled odds ratio of 2.92 (95% CI, 1.39-6.13; P=0.005). CONCLUSION: Nonpharmacologic, nonsurgical weight loss intervention is associated with reduction in the severity of @entity1569 in overweight or @entity28 @entity1 . However, more @entity23 with more @entity1 are needed to provide better quality of evidence.
