Proteases in gastrointestinal XXXX .

@entity1 @entity2290 @entity462 @entity5 @entity467 @entity3 @entity563 @entity14 @entity356 @entity1141
@entity462 and @entity563 proteases are involved in @entity5 invasion and @entity3 . In the past few years we investigated the tissue levels of these proteases in @entity356 ( @entity356 ), gastric precancerous changes (CAG), @entity14 ( @entity14 ) and the plasma and serum levels of proteases in several @entity5 , using ELISA methods. Significantly higher antigen levels were found not only in @entity356 tissue but also in CAG with respect to the levels found normal tissue; with respect to CAG, @entity1 with @entity1141 had higher levels than @entity1 without @entity1141 . The same findings were obtained in @entity14 . In general protease levels correlated with the major histomorphological parameters, such as grading and histotype in @entity356 as well as in @entity14 . Tissue protease levels had a strong prognostic impact in @entity356 , in which @entity2290 was singled out by multivariate analysis as the major prognostic factor, and @entity14 . The plasma levels of @entity2290 ( @entity2290 ) and the serum levels of @entity467 were significantly increased in @entity1 with @entity5 . In conclusions, @entity462 and @entity563 proteases may have a part not only in @entity356 and @entity14 invasion and @entity3 , but also in the progression of gastric precancerous changes into @entity5 . They are strong prognostic factors in @entity356 and @entity14 . These proteases may also have a role as @entity5 markers in the early diagnosis of @entity5 .
