BAL levels of XXXX do not change before or during acute rejection in lungtransplant recipients.

@entity1 @entity5924 @entity697 @entity8923
STUDY OBJECTIVE: @entity697 ( @entity697 ) of the allograft is a major clinical problem after lungtransplantation. Repeated episodes of @entity697 increase the risk of developing @entity5924 , the main cause of mortality in this @entity1 group. It is believed that @entity697 is caused by T-lymphocytes reacting to donor antigens and in turn activating antigen presenting cells (APC) such as alveolar macrophages. Hypothetically, the interferon-gamma inducing cytokine @entity8923 released from activated macrophages can play a role in the development of @entity697 by modulating cytotoxic T-lymphocytes. DESIGN: To determine whether @entity8923 may serve as a marker of @entity697 , we retrospectively analysed the concentration of soluble @entity8923 protein and inflammatory cells in bronchoalveolar lavage fluid (BAL) from lungtransplant recipients. @entity1 : To minimize confounding factors, eight pairs of @entity1 were matched for age, gender, pre-op diagnosis, type of operation, absence of infection and time post transplant. METHODS: BAL levels of @entity8923 (ELISA) and BAL cell differentials were analysed before, during and after an episode of @entity697 and compared with the matched control group. CONCLUSION: We found no changes in @entity8923 concentration in BAL associated with @entity697 . @entity8923 in BAL did not correlate with BAL lymphocyte percentage. We conclude that change in soluble @entity8923 protein does not constitute a useful marker of acute rejection in lung allograft recipients.
