Growth factor regulation of XXXX primordial germ cell development.

@entity10898 @entity10245 @entity11493 @entity641 @entity19 @entity22618
This chapter focused on three key regulators of PGC survival and proliferation; @entity10898 , @entity22618 , and @entity10245 . The survival of all animal cells may require multiple polypeptide factors and PGCs seem to be no exception (Fig. 7). A number of lines of evidence suggest that membrane-bound forms of @entity10898 may be required for PGC survival. These data suggest an exquisite mechanism for controlling both PGC survival and migration. Thus PGCs that stray from the normal migratory pathway might be eliminated through programmed cell death. @entity10898 , together with @entity22618 , can stimulate PGC proliferation in culture and it seems likely that @entity22618 or a related cytokine may function in vivo to regulate PGC survival and proliferation. Animals doubly deficient in @entity22618 and its relatives may soon allow the roles of these cytokines in PGC development to be determined. Although @entity10245 is a potent PGC mitogen in vitro, whether PGCs ever encounter @entity10245 in vivo remains questionable since in culture it alters both the proliferative and developmental potential of PGCs. @entity641 or @entity11493 may be important negative regulators of PGC development, and @entity19 lacking these factors should allow their role in PGC development to be assessed.
