Degranulatory action of XXXX on blood eosinophil leukocytes in vivo and in vitro.

@entity35 @entity112 @entity172 @entity53
The degranulatory activity of @entity53 was tested on blood eosinophil leukocytes in vivo and in vitro. Treatment of adult ovariectomized @entity35 with 30 micrograms @entity53 /100 g body wt. increased the percentage of degranulated eosinophils from 10% to about 70% at 6 or 24 h after treatment, and increased the rate of in vitro eosinophil degranulation of those eosinophils that were non-degranulated at the time of blood sample collection. The addition of @entity53 to blood samples from untreated ovariectomized @entity35 (0.05 micrograms/ml) increased the percentage of eosinophils degranulated in vitro at 1 h of incubation from 20% to near 60%. It is suggested that @entity172 acts directly on the eosinophils, probably via specific hormone receptors. Considering the hypothesis that eosinophils are involved in the mediation of a group of responses to @entity172 in the uterus, it is proposed that the hormone-induced degranulation of these cells may have physiological implications in the regulation of the intensity and duration of the eosinophil-mediated responses. In addition, @entity172 -induced eosinophil degranulation may interfere with the action of eosinophils that have migrated to other target organs (lymphoid organs, etc.) under the action of other agents (glucocorticoid hormones, @entity112 , etc.) or conditions (immune reactions, etc.).
