THYROID FUNCTION AND METABOLIC SYNDROME: A CROSS-SECTIONAL STUDY IN OBESE AND OVERWEIGHT XXXX .

@entity1 @entity4051 @entity6 @entity28 @entity1955 @entity2973 @entity413 @entity164 @entity209 @entity65 @entity165 @entity1374
OBJECTIVE: @entity209 ( @entity209 ) is associated with increased risks of developing @entity65 and @entity164 2 @entity6 . @entity1374 is also a known @entity65 factor. In @entity28 patients, serum thyroid-stimulating hormone (TSH) levels tend to be higher than in lean controls. The objective of this study was to assess potential associations between serum TSH levels and @entity209 as well as individual components of @entity209 . METHODS: This was a cross-sectional observational study of @entity28 and @entity2973 @entity1 seen for initial evaluation at the Boston Medical Center weight-management clinic between February 1, 2013 and February 1, 2014. Demographic, anthropometric, and laboratory data including serum TSH, insulin, @entity413 , hemoglobin A1c, and lipid levels were obtained from electronic medical records. Associations between serum TSH levels and presence of @entity209 and its components were assessed. RESULTS: A total of 3,447 @entity1 , 75.6% female and 38% African American, without known @entity1374 , were included. Mean    SD age was 46.74    15.11 years, and mean    SD body mass index was 36.06    9.89 kg/m(2). Among 1,005 @entity1 without missing data, the prevalence of @entity209 was 71.84%. In @entity1 with @entity209 , the median serum TSH was 1.41  IU/mL, compared with 1.36  IU/mL in @entity1 without @entity209 (P = .45). In multivariate models, there was no significant association between serum TSH levels and the presence of @entity209 , adjusting for age, sex, race, education, socioeconomic status, and smoking. There were also no significant associations between serum TSH and individual components of the @entity209 . CONCLUSION: Serum TSH level does not appear to be a potentially modifiable risk factor for @entity209 in @entity28 and @entity2973 individuals. ABBREVIATIONS: BMI = body mass index FT4 = free @entity1955 HDL-C = high-density-lipoprotein @entity165 @entity4051 c = hemoglobin A1c @entity209 = @entity209 SE = standard error TSH = thyroid-stimulating hormone.
