XXXX : early determination of prognosis.

@entity1 @entity154 @entity82 @entity648 @entity1157 @entity2876 @entity1575 @entity528
Analyses of bile @entity648 during the first month after Kasai operations, and of the liver biopsies obtained at the time of initial surgery, were done in 67 @entity1 with @entity2876 . @entity648 excretion (milligrams per day) was determined as the product of the bile volume and its concentration. Operative liver biopsies were evaluated for @entity82 , bile duct proliferation, @entity1157 , @entity528 ; the severity of each abnormality was graded on a scale of 0 to 4. A forward stepwise regression procedure using the Cox proportional hazards model identified the relationship between survival and covariants. Thirty-nine of 67 @entity1 died. Of these, 38 excreted less than 6 mg of @entity648 per day during the first postoperative month. The other @entity1 died of a coexisting @entity154 . Nine other @entity1 who excreted less than 6 mg of @entity648 per day are alive but are either jaundiced or awaiting transplantation. Nineteen @entity1 who excreted greater than or equal to 6 mg of @entity648 per day are alive (mean follow-up, 61 months) with normal or near-normal liver function. The severity of @entity1575 , bile duct proliferation, and @entity1157 did not correlate with survival, whereas @entity528 were highly significant (P less than or equal to .000 and P less than or equal to .0003, respectively). Twenty-six @entity1 with grade 1-4 giant cell transformation or grade 2-4 parenchymal degeneration had a mean survival of 11 months.(ABSTRACT TRUNCATED AT 250 WORDS)
