[Increased blood cell destruction during vigorous regeneration of bone marrow after CAMBO-VIP chemotherapy for XXXX ].

@entity1 @entity2104 @entity5 @entity648 @entity1893 @entity31499
Alternating non-cross-resistant chemotherapy has been induced for the treatment of @entity1893 ( @entity1893 ) with the aim of cure, even in advanced cases. We formulated a new high dose regimen, CAMBO-VIP, which was a weekly treatment. They were administered during alternate weeks for a total period of 12 weeks. We obtained high response rate and prolonged disease-free survival with this regimen. We noticed the elevation of serum LDH level in some @entity1 at or shortly after the completion of CAMBO-VIP treatment. LDH elevation was not associated with liver function abnormality in terms of elevation of GOT or total @entity648 . All of these @entity1 were in complete or partial response with no evidence of @entity5 progression. An LDH isozyme study which was done at the time of LDH elevation showed elevation of both LDH1 and LDH2. Interestingly serum @entity2104 was undetectable in all 6 @entity1 measured at the time of LDH elevation. @entity31499 and leukoerythroblastosis in peripheral blood were also observed in all of these @entity1 . These abnormalities including LDH elevation returned to normal within a rather short period, usually within 1 to 3 weeks. From these observations, it is most likely that these abnormalities were due to excessive blood cell destruction, which was observed in association with rapid recovery from myelosuppression.
