Effectiveness of Two Novel Anionic and Cationic XXXX Complexes in the Treatment of @entity421 .

@entity59385 @entity137 @entity171 @entity3478 @entity19 @entity900 @entity5834 @entity1391 @entity421 @entity10440 @entity902
UNASSIGNED: Aim: This study aimed to characterize the cellular basis of the @entity902 @entity137 of two novel @entity902 complexes, 3Pt and 1Pt, in comparison with that of @entity900 . 3Pt comprises anionic @entity1391 moieties, while 1Pt comprises neutral aromatic ligands. Methods: We compared the cytotoxic potency of 3Pt and 1Pt with that of @entity900 in @entity421 cell lines and an orthotopic @entity19 model. Results: The cytotoxic potency of 3Pt was markedly higher than that of @entity900 in all cell lines. Both novel @entity902 complexes showed a complete lack of cross resistance in @entity900 -resistant cells. @entity5834 enhanced the cytotoxic potency of these novel @entity902 complexes, as observed for @entity900 . Apoptosis after drug administration was observed by DNA ladder formation and an @entity10440 /PI assay. DNA double-strand breaks were confirmed by phosphorylation of histone H2AX. In vivo, the antitumor activity of 3Pt and 1Pt was superior and similar, respectively, to that of @entity900 . Both novel @entity902 complexes exerted strong antitumor effects on @entity421 in vitro and in vivo. Conclusions: 3Pt may be an effective drug for the treatment of @entity3478 because the @entity59385 moiety has a high affinity to bone, as exhibited by @entity171 , and is expected to decrease the incidence of side effects at extraskeletal sites and overcome drug resistance. Cationic 1Pt may also be an effective antitumor drug because of its unique chemical structure and properties. Further investigations to detail the antitumor effects of these ionic Pt complexes on @entity421 are warranted.
