Prospective study of self-reported XXXX and risk of @entity1820 .

@entity1 @entity6 @entity19 @entity1721 @entity1820 @entity418 @entity420 @entity356
BACKGROUND: Although @entity356 ( @entity356 ) incidence rates in the United States have decreased, the rates of @entity418 ( @entity418 ) and @entity420 ( @entity420 ) have increased. Obesity increases the risks of @entity418 and @entity420 , and the associations may be partially mediated by insulin resistance. A few case-control studies have shown an association between @entity6 and an increased risk of @entity420 . METHODS: We prospectively examined the association between @entity6 and @entity1820 in a cohort of 469,448 @entity1 in the United States, ages 50 to 71 at baseline. Cox proportional hazards regression was used to estimate the HR and 95% CI for @entity1820 , controlling for multiple potential confounders, including body mass index (BMI). RESULTS: We observed no association of self-reported @entity6 with risk of @entity420 , HR (95% CI) = 0.98 (0. @entity19 .31), @entity1721 ( @entity1721 ), HR (95% CI) = 1.02 (0.60-1.74), or @entity356 , HR (95% CI) = 0.98 (0.70-1.37). However, @entity6 was significantly associated with an increased risk of @entity418 , HR (95% CI) = 1.89 (1.43-2.50). The significant association between @entity6 and risk of @entity418 remained after adjustment for BMI, HR (95% CI) = 1.70 (1.28-2.26) and did not differ by BMI strata (P(interaction) = 0.83). The significant association was unchanged when restricting to only overweight subjects (BMI 25 to  <=30), HR (95% CI) = 1.83 (1.18-2.85). CONCLUSIONS: We found a significant association between self-reported @entity6 and increased risk of @entity418 . IMPACT: Our results suggest that the metabolic and hormonal changes related to @entity6 may play a role in the etiology of @entity418 independently from BMI.
