Refined Frequency Doubling Perimetry Analysis Reaffirms Central Nervous System Control of XXXX .

@entity1 @entity2194 @entity227 @entity16 @entity726 @entity14827 @entity191 @entity735 @entity179 @entity13635
PURPOSE: Refined analysis of frequency doubling perimetric data was performed to assess binocular @entity227 in @entity1 with comparable degrees of bilateral @entity16 , to determine whether unilateral visual field loss is random, anatomically symmetric, or non-random in relation to the fellow eye. METHODS: Case control study of 41 consecutive @entity1 with bilaterally mild to severe @entity726 ; each @entity2194 was paired with randomly-selected co-isopteric left eye loci, performing 690,000 (10,000 complete sets of 69 loci) such iterations per subject. The potential role of anatomic symmetry in bilateral @entity227 was also assessed by pairing mirror-image loci of the right- and @entity2194 . The mean values of the random co-isopteric and the symmetric mirror pairings were compared with natural point-for-point pairings of the two eyes by paired t-test. RESULTS: Mean unilateral Matrix threshold across the entire 30-degree visual field were 17.0 dB left and 18.4 dB right (average 17.7). The better of the naturally paired concomitant loci yielded binocular equivalent mean bilateral Matrix threshold of 20.9 dB, 1.6 dB higher than the population mean of the 690,000 @entity13635 (t = -10.4; P < 10(-12)). Thus, a remarkable natural tendency for conservation of the binocular Matrix visual field was confirmed, far stronger than explicable by random chance. Symmetric pairings of precise mirror-image loci also produced values higher than random co-isopteric pairings (   1.1 dB; t = -4.0; P = 0.0004). CONCLUSIONS: Refined data analysis of paired Matrix visual fields confirms the existence of a natural optimization of binocular visual function in severe @entity726 via interlocking fields that could only be created by CNS involvement. The disparity of paired Matrix threshold values at mirror-image loci was also highly nonrandom and quantitatively inverse from the expected if anatomic symmetry factors were merely passively contributing systematically to the compensatory binocular Matrix effect. TRANSLATIONAL RELEVANCE: The paired eyes and brain are reaffirmed to function as a unified system in the progressive age-related @entity14827 chronic open @entity726 , maximizing the binocular visual field. Given the extensive homology of this disorder with other age-related neurodegenerations, it is reasonable to assume that the brain will similarly resist simultaneous bilateral loss of paired functional zones in both hemispheres in diseases like @entity191 . @entity735 at all stages of the disease appear to provide a highly accessible paired-organ study model for developing therapeutics to optimize conservation of function in @entity179 .
