Circulating matrix metalloproteinases and their inhibitors in XXXX and @entity1028 .

@entity1 @entity1552 @entity449 @entity1476 @entity2843 @entity439 @entity1495 @entity547 @entity169 @entity1028
AIM: There is evidence supporting the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in aortic and abdominal wall connective tissue degeneration, resulting in @entity439 and @entity547 formation. Furthermore, clinical association studies have demonstrated increased prevalence of abdominal wall hernias in @entity1 with @entity449 . Our objective was to estimate the levels of MMPs and TIMPs in the blood of @entity1 with @entity449 and @entity169 , in order to investigate whether there is potential pathogenic linkage of impaired collagen metabolism. METHODS: Plasma concentrations of @entity1495 , @entity1476 , @entity2843 and @entity1552 were quantified using ELISA in 33 male @entity1 with @entity1028 and 91 male @entity1 with @entity169 . They were consecutive @entity1 undergoing repair during the study period. The same substances were measured in 35 healthy male controls. RESULTS: @entity1495 and @entity1476 concentrations were lower in the plasma of @entity1 with @entity169 and @entity1028 than controls, with @entity547 @entity1 having the lowest circulating levels. The levels of @entity1552 were significantly elevated in @entity1 with @entity169 and significantly reduced in @entity1 with @entity449 , whereas opposite correlations were found for circulating @entity2843 . CONCLUSION: Different patterns of circulating MMP and @entity2843 levels were found in @entity1 with @entity439 and @entity547 compared with controls. Underlying pathogenic processes implicating MMPs and TIMPs in connective tissue metabolism are expressed by differing plasma levels in the two disease states. Further research including combined plasma and tissue analyses is required to further investigate potential common pathogenesis of these diseases.
