BONE MINERAL DENSITY IN XXXX WITH ADDISON DISEASE ON REPLACEMENT THERAPY WITH @entity617 .

@entity1 @entity251 @entity170 @entity79 @entity5343 @entity701 @entity14951 @entity2145 @entity617
OBJECTIVE: In @entity5343 ( @entity5343 ), replacement with @entity617 may result in lower @entity79 ( @entity79 ) compared with @entity701 therapy. However, the number of @entity1 studied on @entity617 is small and the results are conflicting. We conducted a cross-sectional study to determine @entity79 and its relation with therapy in @entity1 on physiologic doses of @entity617 replacement. METHODS: Forty-one consecutive @entity1 (31 males, age [mean    SD] 50.9    13.0 years), receiving @entity617 ( @entity701 equivalent [HCE] 13.0    3.0 mg/m(2)) for 104    95 months were studied. @entity79 was evaluated by dual-energy X-ray absorptiometry and compared with an age- and sex-matched reference group of healthy Indian subjects (n = 677). RESULTS: Among males, @entity79 Z-scores (mean [95% confidence interval {CI}]) at lumbar spine (-0.42 [-0.80, -0.04]), femoral neck (-0.50 [-0.95, -0.06]) and total hip (-0.58 [-0.90, -0.26]) were significantly lower than the reference population. Z-scores in female @entity1 did not differ from controls. Among postmenopausal females and males >50 years, 43% had @entity170 (T-score  <=-2.5), as compared with 25% in the reference group (P = .04). There was no correlation between @entity79 Z-scores and HCE dose or duration of therapy. On multivariate regression analysis, body mass index was the only significant predictor of @entity79 . A high proportion of males (45%) had low serum @entity251 (<300 ng/dL), but there was no correlation between @entity251 and @entity79 . CONCLUSIONS: Male @entity1 with @entity5343 receiving physiologic @entity617 replacement had a small but significant diminution in @entity79 at all sites. ABBREVIATIONS: ACTH = adrenocorticotropic hormone BAP = bone-specific alkaline phosphatase @entity79 = @entity79 BMI = body mass index CI = confidence interval HCE = @entity701 equivalent 25 ( @entity2145 ) D3 = @entity14951 @entity5343 = @entity5343 .
