Combined expression of aldehyde dehydrogenase 1A1 and XXXX is associated with @entity1600 and poor survival in @entity0 @entity1 following @entity786 treatment.

@entity1 @entity0 @entity1600 @entity786 @entity3546 @entity14215
UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546
