Metabolic response to starvation. I. Relative effects of pregnancy and sex steroid administration in the XXXX .

@entity1 @entity230 @entity844 @entity1420 @entity4053 @entity53 @entity412 @entity1270 @entity6178 @entity35 @entity1718 @entity5420
Increased sensitivity to a fast with rapid onset of @entity1270 , hypoalaninemia, and @entity4053 is characteristic of @entity35 and @entity1 gestation. The present study examines the role of sex @entity230 in the development of these metabolic changes. Subgroups of female rate received 10 microgram of @entity53 (E), 10 mg of @entity1420 (P), or the two in combination (E + P) s.c. daily for 5 days. Control @entity35 (C) received @entity5420 oil alone. Different groups were starved 12, 24 and 48 hr during days 4 and 5 or treatment. Plasma substrate and insulin responses were measured and compared to results of similar studies performed on @entity35 in late gestation. Administration of E or P along had no significant effects on measured parameters as compared to control values. However, the combined E + P regimen resulted in significantly higher @entity1270 , greater hypoalaninemia, and relatively higher @entity412 concentrations than in control groups during fasting. Plasma @entity412 , free @entity844 , and @entity6178 concentrations in the pregnant group exceeded values of both the E + P and control animals. However, plasma free @entity1718 in the E + P group were significantly lower as compared to control values during starvation. These data suggest that the combined effects of @entity53 and @entity1420 enhance ketogenesis and hypoalaninemia independent of the fetal-placental unit during starvation in pregnancy. Since the ketogenic effect was associated with a relative suppression of plasma free @entity1718 , this may be indicative of a direct action of these hormones on hepatic disposition of free @entity1718 and/or the biosynthetic pathways for @entity6178 body production.
