Clinical significance of positive platelet immunofluorescence assay in adult immune XXXX .

@entity1 @entity548 @entity1423 @entity882 @entity1415 @entity4125 @entity1503 @entity3039 @entity811
@entity3039 ( @entity3039 ) is a relatively common @entity1503 manifested by low platelet count due to immune-mediated @entity1423 and/or suppression of platelet production. This study aim was to evaluate characteristics and clinical presentation of adult @entity1 with @entity3039 and exploring the clinical value of platelet antibodies assay in proposed cases in Iranian population. In this prospective case series 46 adult @entity1 with @entity3039 and platelet count of  <100  *  10(9)/L, referred to the Taleghani Medical Center, Tehran, Iran between 2007 and 2009 were evaluated. There were 26 females and 20 males (1.3:1) with mean age of 38.9      19.7  years. The platelet autoantibodies were measured by means of indirect platelet suspension immunofluorescence test. According to our results, 7 @entity1 (15.2  %) displayed a positive platelet antibody assay. There was a significant negative correlation between platelet count and antibody level (r  =  -0 0.59; p  <  0.001). Additionally, a positive correlation between platelet count and @entity1 ' age (r  =  0.302; p  =  0.042) was detected. 20 @entity1 (56.5  %) were symptomatic at presentation and the most common @entity548 signs were @entity4125 , @entity4125 and @entity1415 . Results indicated no significant correlation between increased platelet antibody level and @entity548 manifestations except for @entity811 (r  =  0.435; p  =  0.02) and @entity1415 (r  =  0.382; p  =  0.015). Disclosure of platelet autoantibodies and the consequential @entity882 associated to some extent but not completely with the propensity to bleed which necessitates more factors to be evaluated.
