Current drug therapy and pharmaceutical challenges for XXXX .

@entity1 @entity296 @entity137 @entity1527 @entity5220 @entity344 @entity1526 @entity281 @entity16580
UNASSIGNED: One of the most significant health problems in the American continent in terms of @entity1 health, and socioeconomic impact is @entity1526 , caused by the protozoan parasite @entity1527 . Infection was originally transmitted by reduviid insects, congenitally from mother to fetus, and by oral ingestion in sylvatic/rural environments, but blood transfusions, organ transplants, laboratory accidents, and sharing of contaminated syringes also contribute to modern day transmission. Likewise, @entity1526 used to be endemic from Northern Mexico to Argentina, but migrations have earned it global. The parasite has a complex life cycle, infecting different species, and invading a variety of cells - including muscle and nerve cells of the heart and gastrointestinal tract - in the @entity1 host. @entity1 @entity281 outcome is a potentially fatal @entity296 , and @entity344 . In absence of a vaccine, vector control and treatment of @entity1 are the only tools to control the disease. Unfortunately, the only drugs now available for @entity1526 , Nifurtimox and @entity5220 , are relatively toxic for adult @entity1 , and require prolonged administration. @entity5220 is the first choice for @entity1526 treatment due to its lower side effects than @entity16580 . However, different strategies are being sought to overcome @entity5220 's @entity137 including shorter or intermittent administration schedules-either alone or in combination with other drugs. In addition, a long list of compounds has shown trypanocidal activity, ranging from natural products to specially designed molecules, re-purposing drugs commercialized to treat other maladies, and homeopathy. In the present review, we will briefly summarize the upturns of current treatment of @entity1526 , discuss the increment on research and scientific publications about this topic, and give an overview of the state-of-the-art research aiming to produce an alternative medication to treat @entity1527 @entity281 .
