Mesangial IgA deposition in minimal XXXX : coincidence of different entities or variant of @entity1987 ?

@entity1 @entity8 @entity1987 @entity101 @entity2500 @entity281 @entity134 @entity1985 @entity811 @entity7622
BACKGROUND: Mesangial deposition of IgA ( @entity2500 ) is a very rare finding in @entity1987 and has previously been considered a pure coincidence. In the U.S. and Europe only anecdotal case reports exist. To date, there has been no consensus on nomenclature and categorization of this entity. We describe 2 cases of @entity2500 with analogue histological findings but relevant differences in clinical presentation, and we discuss the clinical implications of mesangial IgA deposition in minimal @entity1985 . @entity1 : A 47-year-old female was admitted to hospital with @entity1985 , microscopic @entity811 , arterial @entity101 and slight @entity8 3 weeks after an unspecific @entity281 . A 42-year-old male presented with @entity1985 , microscopic @entity811 , normotension and normal renal function. Both of the @entity1985 were steroid-responsive and @entity134 -dependent. FINDINGS: The clinical presentation of the male @entity1 was consistent with the features of @entity1987 , whereas the female @entity1 combined signs of @entity1987 and @entity8 . Light microscopy revealed mesangial IgA immune deposits and slight @entity7622 . Electron microscopic studies of @entity2500 @entity1 disclose diffuse effacement of glomerular foot processes. CONCLUSION: Our cases and a review of the literature indicate that the histological diagnosis of @entity2500 may comprise different pathogenetic entities. From the clinical point of view, @entity2500 has to be regarded as a minimal @entity1985 with symptomatic or asymptomatic mesangial IgA deposition. IgA deposition constitutes a risk factor for @entity8 and indicates a frequently relapsing course.
