Exploratory longitudinal cohort study of associations of fatigue after XXXX .

@entity1 @entity64 @entity308 @entity1295 @entity148
BACKGROUND AND PURPOSE: The pathogenesis of poststroke fatigue is unclear. In this prospective study, we explored whether reduced physical activity might contribute to poststroke fatigue or be a consequence of it. METHODS: @entity1 with a recent acute @entity64 were assessed at 1, 6, and 12 months with, @entity1295 ( @entity1295 ), a @entity1295 , @entity148 and @entity308 Score, sleepiness, quality of life, and accelerometry (ActivPAL). Bivariate analyses determined associations between fatigue and step count at each time point. Multiple linear regression tested whether 1-month step count independently predicted 6- and 12-month @entity1295 . RESULTS: A total of 136 @entity1 (mean age, 72 years; 64% @entity1 ) attended >= 1 assessment. ActivPAL data were available for 84 (64%), 69 (66%), and 58 (64%) @entity1 at 1, 6, and 12 months, respectively. At 6 and 12 months, a positive @entity1295 was associated with lower daily step counts (P=0.014 and 0.013, respectively). At 1, 6, and 12 months, higher @entity1295 (more fatigue) was associated with lower step count (P<0.001, 0.01, and 0.007), higher @entity308 (P<0.001), @entity148 (P<0.001), and poorer quality of life (P<0.001). Lower daily step count (P<0.002 and 0.006) and greater @entity148 (P<0.001 for both) at 1 month independently predicted higher @entity1295 at 6 and 12 months. CONCLUSIONS: Lower step counts at 1 month independently predicted greater @entity1295 for  <=12 months. Physical activity might be a therapeutic target for poststroke fatigue.
