Unconventional @entity11386 (-) intermediate TCR cells as major T lymphocytes expanding in XXXX .

@entity644 @entity137 @entity19 @entity11386 @entity2132 @entity792
@entity2132 ( @entity2132 ) accompanying @entity792 was induced in (C57BL/6xDBA/2) F(1) @entity19 (H-2(b/d)) by an injection of splenic T cells of parental DBA/2 origin (H-2(d)). In parallel with the onset of @entity644 , an expansion of lymphocytes was induced in the liver and kidney, showing a peak at 2 weeks after the onset of disease. The majority of lymphocytes were of recipient origin (H-2(b/d)). The main lymphocyte subset among T cells at the pre-onset stage and after the onset of disease was CD8(+) @entity11386 (-) CD3(int) cells (of extrathymic, hepatic origin) in both the liver and kidney. @entity11386 (-) CD3(int) cells confer primarily neither NK-like nor NKT-like @entity137 . No induction of these types of @entity137 was observed in these @entity19 with the expansion of @entity11386 (-) CD3(int) cells. This raised the possibility that granulocytes induced in the liver and kidney might be associated with tissue damage. The present results suggest that, similarly to the case of autoimmune-prone @entity19 with genetic background (e.g. MRL-lpr/lpr @entity19 and BXSB @entity19 ), @entity11386 (-) CD3(int) cells of extrathymic, hepatic origin might be crucial lymphocytes involved in the induction of the @entity792 in @entity19 with chronic @entity2132 , in conjunction with Bcells (e.g. B-1 cells).
