The analgesic effect of XXXX as a prophylactic anticonvulsant drug on postcraniotomy @entity158 : a prospective randomized study.

@entity1 @entity1296 @entity2682 @entity5 @entity16 @entity1295 @entity3174 @entity1875 @entity1286 @entity158 @entity282 @entity1937
BACKGROUND: @entity2682 is an anticonvulsant drug that has analgesic properties for acute @entity282 . However, the analgesic effect of @entity2682 as an antiepileptic prophylactic drug on @entity1 undergoing craniotomy is unclear. In this study, we evaluated the postoperative effectiveness of @entity2682 on acute @entity282 when it is used for antiepileptic prophylaxis in @entity1 undergoing craniotomy for @entity5 resection. METHODS: Eighty @entity1 undergoing craniotomy for @entity5 resection were randomly assigned into two groups. @entity1 in Group G (n = 40) received oral @entity2682 (3 x 400 mg), and @entity1 in Group P (n = 40) received oral @entity3174 (3 x 100 mg) for 7 days before the operation and postoperatively. An identical anesthesia protocol was performed for both the groups. Anesthesia was maintained with @entity1875 and @entity1937 infusion. @entity1 -controlled analgesia with @entity1286 was used, and @entity158 levels were measured. The antiepileptic-related side effects, anesthetic consumption, duration of anesthesia and surgery, tracheal extubation time, @entity282 scores, @entity1286 consumption, and sedation scores were recorded. RESULTS: Thirty-seven @entity1 in Group G and 38 @entity1 in Group P completed the study. During the preoperative period in Group G, one @entity1 had severe @entity1295 , one had severe @entity1296 , and one @entity1 's surgical procedure was changed. The median plasma levels of @entity2682 were 34 micromol/mL (range, 23-51 micromol/mL) in 34 @entity1 . In Group P, one @entity1 withdrew from the study preoperatively and one developed transient @entity16 postoperatively. The demographic data and mean duration of anesthesia and surgery were similar in both the groups. The total @entity1875 and @entity1937 consumption in Group G (1847 +/- 548 mg/3034 +/- 1334 microg) was significantly less than that of Group P (2293 +/- 580 mg/4287 +/- 1282 microg) (P = 0.01). However, tracheal extubation could be done earlier in Group P (4.5 +/- 2 min) than in Group G (16.6 +/- 22 min) (P < 0.001). @entity158 scores were significantly higher in Group P at 15 min, 30 min, and 1 h (P < 0.001). The total @entity1286 consumption was also significantly higher in Group P (33 +/- 17 mg vs 24 +/- 19 mg) (P = 0.01). The postoperative sedation scores were significantly higher in Group G at 15 min, 30 min, 1 h, and 2 h (P < 0.001). CONCLUSIONS: The administration of @entity2682 to @entity1 undergoing craniotomy for @entity5 resection was effective for acute @entity282 . It also decreased analgesic consumption after surgery. However, it may lead to side effects such as delayed tracheal extubation and increased sedation postoperatively.
