Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective XXXX reuptake inhibitors and hypericum extract.

@entity1 @entity1262 @entity308 @entity2600 @entity905 @entity5320 @entity440 @entity5 @entity0 @entity5322 @entity903 @entity1205 @entity3756 @entity837 @entity750 @entity204 @entity2213
Different antidepressant drugs are currently used for the treatment of @entity308 in @entity5 @entity1 , such as second-generation antidepressants and, recently, the extracts of Hypericum perforatum. These agents are susceptible to metabolically-based drug interactions with anticancer drugs. The aim of the present article is to provide an updated review of clinically relevant metabolic drug interactions between selected anticancer drugs and antidepressants, focusing on selective @entity750 reuptake inhibitors (SSRIs) and Hypericum extract. SSRIs can cause pharmacokinetic interactions through their in vitro ability to inhibit one or more cytochrome P450 isoenzymes (CYPs). SSRIs differ in their potential for metabolic drug interactions with anticancer drugs. @entity905 and @entity903 are potent inhibitors of @entity5320 and administration of these SSRIs reduces the clinical benefit of an anticancer drug, such as @entity440 , by decreasing the formation of active metabolites of this drug. @entity1 with @entity0 who receive @entity903 in combination with @entity440 are at increased risk for @entity204 . Other SSRIs, including @entity837 , @entity837 , are weak or negligible inhibitors of @entity5320 and are less likely to interact with anticancer drugs, while @entity3756 causes significant inhibition of this isoform only at high doses. Hypericum extract, by inducing both the @entity5322 and the @entity1262 ( @entity1262 ), can reduce the plasma concentrations of different antineoplastic agents such as @entity2213 , @entity2600 and @entity1205 , thus reducing the clinical efficacy of these drugs. Although these interactions are often predictable, the use of @entity905 , @entity903 and Hypericum extract should be avoided in @entity5 @entity1 .
