[Haemostatic activation in XXXX ].

@entity1 @entity2002 @entity542 @entity49 @entity772 @entity6343 @entity559 @entity3459 @entity130
A relationship between Central Nervous System and coagulation has been known since the work by Goodnight et al5. When an @entity130 occurs tissue damage causes the release of @entity559 -related products, mainly the Tissular Factor. This release produces an activation of the coagulation system specially through its extrinsic path. With this physiopathologic basis we attempt to improve the knowledge of this relation by performing a prospective study at the Intensive Care Unit of our Hospital. The study included 67 @entity1 with cranioencephalic @entity130 alone, with an average Glasgow @entity772 scale score of 10 and a control group consisting of 40 healthy subjects. Two peripheral vein blood extractions were performed, at admission and 24 hours later. @entity3459 parameters (prothrombin time, activated partial thromboplastin time, platelet count and @entity2002 ), @entity49 markers (prothrombin fragments @entity6343 and thrombin-antithrombin complex (TAT)) and thrombolisis markers (D-dimer) were determined. Our results show that early after @entity542 an increase in fragments @entity6343 , TAT and Ddimer occur. After the first 24 hours a significant decrease in @entity49 markers levels is detected. Modification of the global coagulation parameters was also detected. In conclusion, early after a cranioencephalic @entity130 a simultaneous state of @entity49 and thrombolysis occur which may have the purpose of improving the hemostatic balance.
