Tissue XXXX tension: a putative specific indicator of @entity63 in porcine latissimus dorsi flaps.

@entity1707 @entity63 @entity39 @entity209 @entity254 @entity26 @entity450 @entity520 @entity880 @entity544 @entity972 @entity432 @entity413
Free flap surgical procedures are technically challenging, and @entity254 failure may lead to arterial or @entity432 and flap @entity39 . To improve myocutaneous flap survival rates, more reliable methods to detect @entity63 are needed. On the basis of theoretical considerations, @entity544 tension, reflecting intracellular @entity520 , may be suitable indicators of @entity63 . It was hypothesized that tissue @entity544 tension increased rapidly when metabolism became anaerobic and would be correlated with acute venoarterial differences in @entity880 levels, @entity972 levels, and acid-base parameters. Because @entity209 have been observed to be less pronounced in flaps with @entity432 , it was hypothesized that tissue @entity544 tension and venoarterial differences in @entity880 and @entity972 levels and acid-base parameters would increase less during @entity432 than during @entity432 . In 14 @entity1707 , latissimus dorsi myocutaneous flaps were surgically isolated, exposed to acute @entity63 for 150 minutes with complete @entity432 (seven subjects) or @entity432 (seven subjects), and reperfused for 30 minutes. After @entity432 , pedicle blood flow decreased immediately to less than 10 percent of baseline flow. Blood flow decreased more slowly after @entity432 but within 3 minutes reached almost the same low levels as observed during @entity432 . Venous @entity26 saturation decreased from approximately 70 percent to approximately 20 percent, whereas @entity26 uptake was almost arrested. Tissue @entity544 tension increased to two times baseline values in both groups (p < 0.01). The venoarterial differences in @entity544 tension, pH, base excess, @entity413 levels, @entity880 levels, and @entity972 levels increased significantly (p < 0.01). Tissue @entity544 tension measured during the occlusion period were closely correlated with venoarterial differences in pH, base excess, @entity413 levels, @entity880 levels, and @entity972 levels (median r2, 0.67 to 0.92). After termination of arterial or @entity432 , more pronounced @entity450 was observed in the @entity432 group than in the @entity432 group (p < 0.05). @entity26 uptake (p < 0.05) and venoarterial differences in @entity880 and @entity972 levels (p < 0.05) were significantly more pronounced in the @entity432 group. In the @entity432 group, with less pronounced @entity450 , venoarterial differences in acid-base parameters remained significantly different from baseline values before occlusion (p < 0.01). The data indicate that tissue @entity544 tension can be used to detect anaerobic metabolism, caused by arterial or @entity432 , in myocutaneous flaps. The correlations between @entity544 tension and venoarterial differences in acid-base parameters were excellent. Because @entity544 tension can be measured continuously in real time, such measurements are more likely to represent a clinically useful parameter than are venoarterial differences.
