Associations between XXXX onset, D-dimer, and soluble fibrin monomer complex after total knee arthroplasty.

@entity1 @entity1151 @entity1150 @entity1211 @entity11942
BACKGROUND: Prevention and early detection of @entity1211 ( @entity1211 ) is important after arthroplasty of the lower limb. The purpose of this study was to investigate the associations between @entity1211 and hemostatic markers after minimally invasive total knee arthroplasty (MIS-TKA). METHODS: We performed a retrospective study of 50 @entity1 (55 knees) who underwent primary unilateral MIS-TKA with periodic determination of D-dimer and soluble fibrin monomer complex (SFMC) concentrations and with ultrasonography. The development of symptomatic and asymptomatic @entity1211 , location of @entity1150 ( @entity11942 ; proximal or distal), changes in SFMC and D-dimer concentrations, and correlations between hemostatic markers and @entity1211 onset were evaluated. RESULTS: Twenty-six @entity1 (47  %) had an asymptomatic @entity11942 , but none had proximal @entity11942 , @entity1151 , or symptomatic @entity11942 . @entity11942 was detected at postoperative day 1 (POD1) in 16 @entity1 , POD3 in six, and POD5 in three (excluding detections of the same @entity11942 in the same position on different days). @entity11942 onset correlated significantly with SFMC concentration on POD1 and with D-dimer concentration on POD3. The D-dimer concentration did not differ significantly between @entity1 who developed @entity11942 ( @entity11942 +) and those who did not ( @entity11942 -) at each postoperative time. SFMC concentration differed between @entity11942 + and @entity11942 - @entity1 only on POD1. Analysis of each hemostatic marker classified as either within or outside the normal concentration range showed no significant correlations between D-dimer concentration and @entity11942 onset at each period. There were significant correlations between SFMC concentrations and @entity11942 onset on POD1 and POD3. There were also significant correlations between D-dimer positive (+) findings and/or SFMC+ findings and @entity11942 onset on POD1 and POD3. D-dimer+ and/or SFMC+ findings had better specificity on POD1 and a positive predictive value on POD1 and POD3 compared with SFMC+ alone. CONCLUSIONS: SFMC concentration is an effective hemostatic marker for early detection of @entity11942 . D-dimer concentration alone has limited value as a hemostatic marker for early detection of @entity11942 . Measurement of both D-dimer and SFMC concentrations might be a more sensitive diagnostic tool than measuring SFMC concentration alone.
