Plasma XXXX / @entity3542 levels are unchanged after long-term aerobic exercise training in older adults.

@entity1 @entity3542 @entity409 @entity26 @entity1507 @entity450 @entity1674 @entity842 @entity165
Reduced @entity842 (NO) production and bioactivity is a major contributor to @entity409 . Animal data suggest that improvements in endothelial function in response to aerobic exercise training may depend on the duration of the training program. However, no studies have examined changes in NO (as assessed by the major NO metabolites, @entity1507 and @entity3542 , NO(x)) after long-term training in @entity1 . In addition, aging may impair the ability of the vasculature to increase NO with exercise. Thus, we determined whether 24 weeks of aerobic exercise training increases plasma NO(x) levels in sedentary older adults. We also examined changes in forearm blood flow (FBF) at rest and during reactive @entity450 as a measure of vasomotor function. Plasma NO(x) levels were measured in 82 @entity1 and @entity1 using a modified Griess assay. FBF was assessed in a subset of individuals (n = 15) using venous occlusion plethysmography. After 24 weeks of exercise training, there were significant improvements in maximum @entity26 consumption, HDL @entity165 , @entity1674 , and body fat. Changes in plasma NO(x) levels ranged from -14.83 to +16.69 micromol/L; however, the mean change overall was not significant (-0.33 + or - 6.30 micromol/L, p = 0.64). Changes in plasma NO(x) levels were not associated with age, gender, race, HDL @entity165 , @entity1674 , body weight, body fat, or maximal @entity26 consumption. There were also no significant changes in basal FBF, peak FBF, hyperemic response, total hyperemic flow, or minimum forearm vascular resistance with exercise training. In conclusion, improvements in plasma NO(x) levels and FBF are not evident after long-term training in older adults.
