Immunohistochemical investigations on external auditory canal XXXX .

@entity310 @entity470 @entity7790 @entity5479 @entity3540 @entity1758
OBJECTIVE: The aim of the study was to analyze the biological behavior of external auditory canal @entity3540 (EACC). The expression and distribution of relevant markers such as @entity310 ( @entity7790 ), @entity470 ( @entity470 ), and the proliferation marker @entity1758 were studied in comparison with normal auditory meatal skin. BACKGROUND: EACC are uncommon and knowledge concerning etiology and pathogenesis is limited. Whether this is a unique entity remains controversially discussed. MATERIALS AND METHODS: Immunohistochemical methods were used to study the expression and distribution @entity7790 , @entity470 , and the proliferation marker @entity1758 on 15 tissues samples. Only the spontaneous form of EACC was included in this study. RESULTS: Positive immunoreactivity for the proliferation marker @entity1758 could be demonstrated in keratinocytes in the basal and suprabasal layers of the epithelium. The number of @entity1758 -positive proliferating cells in @entity3540 was significantly higher than in normal external auditory skin. @entity3540 epithelium also showed an enhanced expression of @entity7790 and @entity470 . Inflammatory infiltrate was observed in the perimatrix to various degrees. CONCLUSION: These results suggest that similar to the @entity5479 , a chronic inflammatory process underlies the EACC, and the inflammatory stimuli may alter keratinocyte proliferation.
