Neuro-optic cell apoptosis and @entity455 in KKAY XXXX retina.

@entity1 @entity227 @entity455 @entity6 @entity2479 @entity19 @entity164 @entity989
@entity6 is one of the common complications of @entity6 and is the leading cause for @entity1 ' @entity227 and sight loss. However, the mechanism of @entity6 is not clearly defined. The present study was undertaken to investigate neuroretinal apoptosis in different stages in a @entity19 model for @entity6 and the mechanism of @entity6 . KKAY @entity19 with genetic @entity6 , an animal model for @entity164 2 @entity6 , was used in this study. @entity19 were divided into a control group and a @entity6 group. The @entity19 in both groups were sacrificed at one month and three months, and the @entity19 eyeballs were used for making retinal histologic sections. We showed in this study that the apoptotic cell numbers for retinal neural cells in the ganglion cell layer were significantly greater in the @entity6 group than in the control group (p<0.01), as determined by the TUNEL assay. In addition, many more apoptotic retinal neuronal cells were found in the retinal ganglion cell layer and medial part of the inner nuclear layer in the @entity6 group when the @entity19 were sacrificed at three months as compared to those sacrificed at one month (p<0.01). We also studied the ultrastructure of the retinal nerve cells and microvesseles by electron microscopy and demonstrated that the ultrastructure changes for retinal neural cells and @entity989 were observed in, as early as, the early stage of @entity6 . These findings indicate that: i). @entity989 and @entity455 occur in the early stage of @entity6 , ii). apoptosis may be an important mechanism through which @entity2479 is developed, and iii). both @entity2479 and @entity989 should be considered as the @entity6 .
