XXXX bone-stroma interaction and its biologic and therapeutic implications.

@entity5 @entity1 @entity263 @entity3
BACKGROUND: The homing of @entity263 to bone is a nonrandom, multistep process. Previous studies have revealed significant insights into how @entity5 cells can interact with the host microenvironment. In this communication, the author summarizes recent studies from his institution and draws conclusions from data published by others pertaining to the biologic and therapeutic implications of bone @entity3 from @entity263 . METHODS: Tumor models have been established to study cellular interaction between @entity1 @entity263 cells and bone stroma under two-dimensional and three-dimensional conditions. At the author's institution, experiments were conducted to show that @entity263 cell growth and survival are enhanced in coculture with pleuripotent bone stromal cells. A cotargeting concept for the treatment of @entity1 with @entity263 bone @entity3 is introduced. RESULTS: Both genotypical and phenotypical responses were observed to @entity5 epithelium when it was cocultured under three-dimensional conditions. A "vicious cycle" that was mediated by soluble and insoluble molecules secreted by @entity5 and bone may be the key to supporting and sustaining @entity5 colonization in bone. Cotargeting @entity5 and stroma has yielded promising results, both in preclinical models of @entity263 bone @entity3 and in the clinic with @entity1 who were treated with a dual @entity5 -targeting and bone-targeting strategy. CONCLUSIONS: Understanding and targeting the interaction of @entity5 cells and bone stroma may improve the prognosis, reduce the suffering, and increase the survival of @entity1 with advanced bone @entity3 as a consequence of @entity263 .
