Antinociceptive effects of @entity284 combined with XXXX or @entity11988 in @entity1641 .

@entity1641 @entity4931 @entity2704 @entity601 @entity11988 @entity284
REASONS FOR PERFORMING STUDY: To investigate two protocols to provide antinociception in @entity1641 . OBJECTIVES: To evaluate the antinociceptive effects of intravenous @entity284 combined with @entity4931 or @entity11988 in adult @entity1641 . STUDY DESIGN: Randomised, blinded, crossover study. METHODS: Mechanical, thermal and electrical stimuli were applied to the dorsal left and right metacarpus and coronary band of the left thoracic limb, respectively. A thermal stimulus was applied caudal to the withers. The @entity1641 were treated with saline (C), a combination of @entity284 (0.2  mg/kg bwt) and @entity4931 (10   g/kg bwt) ( @entity601 ) or @entity284 (0.2  mg/kg bwt) and @entity11988 (0.05  mg/kg bwt) ( @entity2704 ) at 1  week intervals. Nociceptive thresholds were measured before and at 15  min intervals until 150  min after treatment. Wilcoxon rank-sum and Wilcoxon signed rank tests were used to compare data between groups at each time point and over time within each group, followed by the Bonferroni method to adjust the P value. RESULTS: The mechanical stimulus was the most sensitive test to differentiate the antinociceptive effects of the treatments. Mechanical thresholds were greater after @entity601 than @entity2704 between 15 and 30  min and with both @entity601 and @entity2704 these thresholds were greater than C from 15 to 60  min. Electrical and thermal limb thresholds were greater after @entity601 than C at 15 and 45  min and at 15, 30, 45, 75 and 105  min, respectively. Thermal limb thresholds were greater with @entity2704 than C at 30  min. Thoracic thermal threshold in @entity601 and @entity2704 were higher than C at 45, 75, 90 and 120  min and from 30 to 75  min, respectively. CONCLUSIONS: @entity284 and @entity11988 produced less pronounced mechanical antinociception than @entity601 .
