Aortic elastic properties are impaired in XXXX with Graves' ophtalmopathy.

@entity1 @entity2743 @entity1378 @entity2333 @entity65
BACKGROUND: Aortic elastic properties have been shown to be an important predictor of @entity65 and mortality. @entity1378 was shown to be an important cause of impaired aortic elastic properties both due to the direct effect of the thyroid hormones on the aorta and also due to modulating effects of thyroid hormones on the vascular renin angiotensin system. However, there is no study investigating the aortic elastic properties in Graves's @entity1 who were euthyroid. The goal of the present study was to investigate the aortic elastic properties of @entity1 with @entity2743 ( @entity2743 ) who had been euthyroid for at least 3 months. @entity1 AND METHODS: A cross-sectional study was performed on 47 @entity2743 @entity1 and 27 controls. @entity2333 , aortic strain, aortic distensibility, and @entity2333 indices were calculated from the diameter of the thoracic aorta as measured by transthoracic echocardiography. RESULTS: The @entity2333 index was markedly increased (31    26 vs. 17    8.9; p = 0.015) and aortic strain was markedly reduced (20.3    10 % vs. 25.9    12 %; p = 0.046) in the @entity2743 group relative to the control group. Aortic distensibility was statistically significantly decreased in the @entity2743 group as compared to the control group (9.5    5.7 10(-3)/kPa vs. 13.5    7.1 10(-3)/kPa; p = 0.022). Weak correlations were detected between @entity2743 severity and aortic distensibility (r = -0.333, p = 0.011) as well as the @entity2333 index (r = 0.266, p = 0.044). CONCLUSIONS: Aortic elastic properties were impaired in @entity1 with @entity2743 . Therefore, @entity1 with @entity2743 , especially those with severe manifestations of the condition, should be followed closely with regard to the occurrence of future cardiovascular events.
