Spatial expression of @entity7 in XXXX glioma.

@entity1 @entity7 @entity5 @entity39 @entity146 @entity519 @entity816 @entity463
@entity816 , especially of high grade, is dependent on neovascularization for its growth and progression. The expression of @entity7 ( @entity7 -A), an important angiogenesis factor, has been demonstrated in perinecrotic cells in @entity463 . In order to achieve more knowledge regarding the process of @entity816 angiogenesis and growth we have investigated the expression of @entity7 immunohistochemically in different areas of @entity5 . In 21 @entity1 with @entity816 of varying grade serial stereotactic biopsies were performed. Biopsies were taken from brain adjacent to @entity5 (BAT), @entity5 periphery, and @entity5 center. In the BAT region of high-grade @entity816 , we found a frequent expression of @entity7 in @entity5 cells and less frequent in blood vessels. In the periphery, there was an expression mainly in @entity5 cells while in the center of grade IV @entity5 @entity7 was also frequently expressed in cells adjacent to @entity39 . @entity7 in @entity816 grade II was demonstrated in viable @entity5 cells preferentially in the periphery but also in peripheral vessels and in centrally located @entity5 cells. The findings indicate that, in addition to @entity519 in @entity39 areas there may be other factors that stimulate the expression of @entity7 . It is suggested that @entity7 may be a prerequisite for the @entity146 and infiltrative growth of @entity816 . Therefore, when operating high-grade @entity816 it may be of importance to resect this @entity146 peripheral part of the @entity5 and also to take this finding into account when planning radiotherapy.
