Disclosing genetic risk for @entity301 : effects on XXXX and genetic counseling satisfaction.

@entity1314 @entity1 @entity7617 @entity301
UNASSIGNED: We investigated whether disclosure of @entity301 ( @entity301 ) genetic risk influences @entity1314 ( @entity1314 ) and genetic counseling satisfaction (GCS). @entity1 (n   =   207, age: 45-65   years) were randomized to receive estimated 10-year risk of @entity301 based on a @entity7617 ( @entity7617 ) with or without a genetic risk score (GRS). Risk estimates were disclosed by a genetic counselor who also reviewed how GRS altered risk in those randomized to @entity7617 +GRS. Each @entity1 subsequently met with a physician and then completed surveys to assess @entity1314 and GCS. @entity1 who received @entity7617 +GRS had higher @entity1314 than those who received @entity7617 alone although the absolute difference was small (25.2        2.7 vs 24.1        3.8, p   =   0.04). A greater proportion of @entity7617 +GRS @entity1 had higher GCS scores (17.3        5.3 vs 15.9        6.3, p   =   0.06). In the @entity7617 +GRS group, @entity1314 and GCS scores were not correlated with GRS. Within both groups, @entity1314 and GCS scores were similar in @entity1 with or without family history (p   =   NS). In conclusion, @entity1 who received their genetic risk of @entity301 had higher @entity1314 and tended to have higher GCS. Our findings suggest that disclosure of genetic risk of @entity301 together with conventional risk estimates is appreciated by @entity1 . Whether this results in improved outcomes needs additional investigation.
