Treatment results of adjuvant radiotherapy and salvage radiotherapy after radical prostatectomy for XXXX .

@entity1 @entity263
BACKGROUND: The indications for and the efficacy of radiation therapy after radical operation for @entity1 with @entity263 are not clear. We analyzed the treatment results of adjuvant radiotherapy and salvage radiotherapy after radical prostatectomy. METHODS: Between September 1997 and November 2004, 57 @entity1 received adjuvant radiotherapy or salvage radiotherapy after radical prostatectomy. Fifteen @entity1 received radiation therapy because of positive margins and/or extracapsular invasion in surgical specimens (adjuvant group). Forty-two @entity1 received radiation therapy because of rising prostate-specific antigen (PSA) during follow-up (salvage group). Radiation therapy was delivered to the fossa of the prostate +/- seminal vesicles by a three-dimensional (3-D) conformal technique to a total dose of 60-66 Gy (median, 60 Gy). Biochemical control was defined as the maintenance of a PSA level of less than 0.2 ng/ml. RESULTS: The median follow-up period after radiation therapy was 33 months (range, 12-98 months). Three-year biochemical control rates were 87% for the adjuvant group and 61% for the salvage group. For @entity1 in the salvage group treated without hormone therapy, the preradiation PSA value was the most significant factor for the biochemical control rate. The 3-year biochemical control rate was 93% in @entity1 whose preradiation PSA was 0.5 ng/ml or less and 29% in @entity1 whose preradiation PSA was more than 0.5 ng/ml. No severe adverse effects (equal to or more than grade 3) were seen in treated @entity1 . CONCLUSION: Radiation therapy after radical prostatectomy seemed to be effective for adjuvant therapy and for salvage therapy in @entity1 with a preradiation PSA of 0.5 ng/ml or less. Also, radiation to the fossa of the prostate +/- seminal vesicles, to a total dose of 60-66 Gy, using a three-dimensional (3-D) conformal technique, seemed to be safe.
