The impact of lifecourse socioeconomic position on XXXX events in African Americans: the Jackson Heart Study.

@entity1 @entity65
BACKGROUND: Few studies have examined the impact of lifecourse socioeconomic position (SEP) on @entity65 ( @entity65 ) risk among African Americans. METHODS AND RESULTS: We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with @entity65 events in a large cohort of African Americans. During a median of 7.2-year follow-up, 362 new or recurrent @entity65 events occurred in a sample of 5301 @entity1 aged 21 to 94. Childhood SEP was assessed by using mother's education, parental home ownership, and childhood amenities. Adult SEP was assessed by using education, income, wealth, and public assistance. Adult SEP was more consistently associated with @entity65 risk in @entity1 than in @entity1 : age-adjusted hazard ratios for low versus high income (95% CIs), 2.46 (1.19 to 5.09) in @entity1 and 1.50 (0.87 to 2.58) in @entity1 , P for interaction=0.1244, and hazard ratio for low versus high wealth, 2.14 (1.39 to 3.29) in @entity1 and 1.06 (0.62 to 1.81) in @entity1 , P for interaction=0.0224. After simultaneous adjustment for all adult SEP measures, wealth remained a significant predictor of @entity65 events in @entity1 (HR=1.73 [1.04, 2.85] for low versus high). Education and public assistance were less consistently associated with @entity65 . Adult SEP was a stronger predictor of @entity65 events in younger than in older @entity1 (HR for high versus low summary adult SEP score 3.28 [1.43, 7.53] for @entity1  <=50 years, and 1.90 (1.36 to 2.66) for @entity1 >50 years, P for interaction 0.0846). Childhood SEP was not associated with @entity65 risk in @entity1 or @entity1 . CONCLUSIONS: Adult SEP is an important predictor of @entity65 events in African American @entity1 and in younger African Americans. Childhood SEP was not associated with @entity65 events in this population.
