Epidemiology and emerging resistance in bacterial bloodstream infections in @entity1 with XXXX .

@entity1 @entity3256 @entity5645 @entity796 @entity233 @entity794 @entity1398 @entity25323 @entity1583 @entity4005 @entity5505 @entity526 @entity1536
BACKGROUND: The objective of this study was determine the frequency of bloodstream infections (BSIs) and the causative bacteria and their resistance patterns in @entity1 with @entity1583 ( @entity1583 ) in a large tertiary care university hospital in @entity233 over a 5-year period. METHODS: A total of 2098 @entity1 with @entity1583 with 3703 @entity1398 episodes were included. @entity1 were classified as high-risk (n = 843) and low-risk (n = 1255) groups and evaluated for frequency of BSIs, causative bacteria, and their resistance patterns. RESULTS: The frequency of BSIs was 14.5%. The frequency of gram-negative BSIs in high-risk and low-risk groups was 10.7% and 5.4% (p < 0.001), respectively. The frequency of gram-positive BSIs in high-risk and low-risk groups was 7.0% and 3.9% (p < 0.001), respectively. Gram-negative bacteria predominated (52.6%), with @entity526 (17.3%) and @entity4005 @entity5645 . (11.0%) as the most frequent organisms. Coagulase-negative staphylococci (10.4%) and Corynebacterium @entity5645 . (6.3%) were the most common gram-positive bacteria (35.8%). The rate of @entity25323 (ESBL) production was 45% for @entity526 and 58% for @entity4005 @entity5645 . @entity1536 resistance was 58% for @entity526 and 11% for @entity4005 @entity5645 .. The overall frequency of @entity5505 resistance in @entity796 was 28%, and 87% of Acinetobacter @entity5645 . were multidrug-resistant. Of @entity794 isolates, 24.8% were resistant to @entity3256 . CONCLUSION: The dominating causes of BSIs in @entity1 with @entity1583 in our hospital are resistant gram-negative bacteria, which has made empirical antimicrobial choice a highly challenging issue in this @entity1 population.
