Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in XXXX @entity35 .

@entity1976 @entity2310 @entity2358 @entity2033 @entity8113 @entity179 @entity4207 @entity35 @entity4124
@entity2033 is a chronic @entity179 inherited in an autosomal dominant fashion, and characterized as @entity2358 . @entity8113 has been used to produce an animal model of @entity2033 . In the present study, the effect of treadmill exercise on @entity4207 and motor coordination focusing on the apoptosis in the hippocampus was investigated using @entity8113 -induced @entity2033 @entity35 . @entity2033 was induced by unilateral intrastriatal injection of @entity8113 (2  L of 100 nmol) using stereotaxic instrument. The @entity35 in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 14 days. Spatial learning ability and motor coordination were determined by radial 8-arm maze test and rota-rod test. Immunohistochemistry for @entity4124 and western blot for @entity2310 and @entity1976 were also conducted for the detection of apoptosis. In the present results, spatial learning ability and motor coordination were deteriorated by intrastriatal injection of @entity8113 . In contrast, treadmill exercise exerted ameliorating effect on @entity8113 -induced deterioration of spatial learning ability and motor coordination. @entity1976 expression in the hippocampus was de-creased and expressions of casepase-3 and @entity2310 in the hippocampus were increased in the @entity8113 -induced @entity2033 @entity35 . Treadmill exercise increased @entity1976 expression and decreased expressions of casepase-3 and @entity2310 in the @entity2033 @entity35 . The present results showed that treadmill exercise might ameliorate @entity8113 -induced loss of spatial learning ability and motor coordination by suppressing apoptosis in the hippocampus.
