Effects of long-term inhaled corticosteroids on adrenal function in XXXX with @entity565 .

@entity1 @entity748 @entity4545 @entity2995 @entity565 @entity17013 @entity16179 @entity701 @entity5023 @entity288
BACKGROUND: Inhaled corticosteroids (ICSs) are effective @entity565 controllers, but long-term use could lead to adverse effects. OBJECTIVE: To examine adrenal responsiveness of @entity1 with persistent @entity565 treated with long-term ICSs. METHODS: Morning plasma @entity701 levels before and 30 minutes after @entity4545 ( @entity4545 ) (1 microg intravenously) stimulation were compared. Primary end points included mean prestimulation and poststimulation @entity701 levels; secondary end points included morning @entity701 level of 5 microg/dL or less, post- @entity4545 stimulation @entity701 level of 18 microg/dL or less, and/or a net change of 7 microg/dL or less from baseline. RESULTS: A total of 103 @entity748 @entity1 (29 in the @entity2995 group, 18 in the @entity17013 group, 45 in the @entity5023 group, and 11 in the oral @entity288 group [positive controls]) completed the study. Mean daily @entity16179 doses and durations were as follows: @entity2995 : 448 microg for 36 months; @entity17013 : 1,181 microg for 41 months; and @entity5023 : 745 microg for 19 months. Eleven of 30 @entity1 taking high-dose ICSs (10 of 28 taking @entity5023 and 1 of 2 taking @entity17013 ) had both low morning @entity701 levels and abnormal post- @entity4545 stimulation @entity701 levels. Few @entity1 taking lower doses of any @entity16179 had abnormal results. CONCLUSIONS: @entity1 who require long-term treatment with high-dose ICSs may have abnormal morning plasma @entity701 levels and reduced responsiveness to @entity4545 stimulation. Careful monitoring of adrenal function should be considered in such @entity1 .
