[Significance of expression of stromal cell derived factor 1 and XXXX in invasive @entity0 ].

@entity172 @entity0 @entity1420 @entity5 @entity1570 @entity3 @entity1722 @entity436
OBJECTIVE: To study the expression of stromal cell derived factor 1( @entity1570 )/ @entity436 and their association with clinicopathologic features and lymph node @entity3 in invasive @entity0 . METHODS: The expression of @entity1570 was studied by immunohistochemistry and in-situ hybridization. Immunohistochemical study for @entity436 was also performed. The correlation with various clinicopathologic parameters was analyzed. RESULTS: (1) @entity1570 was mainly expressed in @entity5 cells and the level of its expression (both membranous and cytoplasmic) in lymph node-positive group was higher than that in lymph node-negative group (P = 0.033). Only cytoplasmic expression correlated with the number of positive lymph node involved by @entity3 , TNM @entity5 stage, histologic grade, @entity5 dimension and @entity172 receptor status (P < 0.05). (2) @entity1570 protein was also detected in the endothelial cells, although its mRNA was rarely detected. @entity1570 staining in lymphatics was associated with positive lymph node (P = 0.005) and @entity1570 staining in blood vessels correlated with stromal lymphocytic reaction (P = 0.001). The extent of nodal involvement was higher in the group with positive @entity1570 staining in blood vessels and with prominent lymphocytic reaction than that in other groups with one or neither of the two features (P < 0.05). (3) On the other hand, @entity436 was mainly expressed in @entity5 cells (both nuclear and cytoplasmic); and the level of its expression in lymph node-positive group was higher than that in lymph node-negative group (P = 0.005). Only cytoplasmic expression correlated with the number of positive lymph node involved by @entity3 , TNM @entity5 stage, histologic grade, @entity5 dimension and @entity1722 status (P < 0.05). The nuclear expression of @entity436 was only correlated with @entity1420 receptor status (P < 0.01). The cytoplasmic expression @entity436 also positively correlated with @entity1570 expression (P = 0.001). CONCLUSIONS: @entity1570 and @entity436 can serve as biomarkers for diagnosis and prediction of lymph node @entity3 , as well as potential therapeutic targets in invasive @entity0 . The difference in localization and staining patterns may also carry different significance.
