The vertical linear vestibulo-ocular reflex in XXXX with a hyperactive response during horizontal angular acceleration.

@entity1 @entity394 @entity2194 @entity2915
OBJECTIVE: In clinical routine, some @entity1 show a bilateral hyperactive response of the @entity2194 ( @entity2194 ). The aim of this prospective study was to determine whether these @entity1 also show @entity2915 of the linear VOR (LVOR). MATERIAL AND METHODS: In 10 @entity1 with a hyperactive @entity2194 (total amplitude of post-rotatory nystagmus > 400 degrees per 30 s) and 10 healthy subjects the @entity2194 (stopped after 180 s of rotation at 90 degrees/s) and vertical LVOR (amplitude 5 cm, frequency 1.2 Hz) were tested with eyes open in the dark. During vertical linear acceleration, each subject was instructed to look at an earth-fixed target and they performed vertical smooth pursuit as stationary observers. RESULTS: The mean eye velocity of the @entity2194 was significantly higher in the @entity1 than the healthy subjects (19 vs 5 degrees/s; p = 0.00016). During vertical linear acceleration in darkness (49 vs 23 degrees/s; p = 0.004) and combined maculo-visual stimulation (88 vs 52 degrees/s; p = 0.007) the @entity1 showed a significantly higher mean vertical eye velocity. When vertical smooth pursuit was performed, no significant differences were registered. All 20 subjects showed a significant (p = 0.01) positive Spearmnan correlation (rs = 0.79) between the eye velocities of @entity2194 and LVOR. CONCLUSION: @entity1 with a hyperactive @entity2194 also showed @entity2915 of the LVOR. Because two different sensory end organs and neuronal pathways are involved in these responses, a central rather than a peripheral @entity394 must be held responsible.
