XXXX decreases the survival rate of HeLa cells with stable knockdown of survival motor neuron protein.

@entity1 @entity274 @entity3403 @entity273 @entity179 @entity2057
The mutations of survival motor neuron (SMN) gene result in @entity2057 ( @entity2057 ), a common @entity179 . Some of the motor neurons undergoing cell death is the predominant characteristic in @entity2057 pathology. However, the viability and sensitivity to stresses of other cell types also need to be determined. In this article, we established HeLa stable cell line with inducible SMN knockdown to study its viability and sensitivity to oxidative stress. SMN knockdown in the HeLa stable cell line was induced by @entity3403 . The proliferative and survival rates of SMN knockdown cells with or without @entity273 ( @entity274 ) treatment were determined. Our results showed that the proliferative rate of SMN knockdown cells decreased only slightly compared with that of the cells without @entity3403 treatment. In contrast, after @entity274 reached certain concentrations, the survival rate of SMN knockdown cells decreased significantly. Our data indicate that SMN knockdown alone is not critical to cell viability. However, when SMN knockdown cells are under stress, such as oxidative stress, their survival rate may significantly decrease. Our results will be helpful to prevent the detrimental effect caused by the cell death of non-motor neurons under stress in @entity2057 @entity1 . In addition, the cell model we established can be used to study the mechanism and screen drugs to prevent the detrimental effects in cases of @entity2057 .
