The role of cytokines as inflammatory mediators in XXXX .

@entity1 @entity650 @entity644 @entity6571 @entity310 @entity1468 @entity1011 @entity414 @entity3064 @entity1851
INTRODUCTION: This study is to determine the concentrations of @entity650 , @entity310 , and @entity1851 ( @entity1851 ) in @entity1 with @entity1468 , and compare with those of gestational age- matched normotensive pregnant @entity1 and to correlate @entity1851 levels with markers of organ damage in @entity1 with @entity1468 . METHODS: This was a case control study of fifty @entity1 with @entity1468 and fifty gestational age matched pregnant @entity1 with normal blood pressure. The @entity1 were drawn from The Antenatal Clinic of The Lagos University Teaching Hospital. Severe @entity1468 was defined as systolic blood pressure >= 160 mmHg and/or diastolic blood pressure >= 110mmHg and >= 2+ of @entity644 . After obtaining an informed consent, each @entity1 completed a structured questionnaire. The questionnaire sought information on socio-demographic and clinical data. From each @entity1 , mid-stream urine was collected for urinalysis and culture, and blood sample was collected for biochemical analysis. Comparisons of continuous variables and categorical variables were done using the Student's t test and Chi square test respectively. Correlation analysis was used to determine the associations between variables. Statistical significance was set at P. RESULTS: The @entity1 were similar in their socio demographic characteristics. There was a statistically significant difference in the systolic blood pressure (p < 0.0001), diastolic blood pressure ( p < 0.0001), @entity414 ( p < 0.0001), @entity6571 ( p < 0.0001), @entity3064 ( p < 0.0001), @entity1011 ( p < 0.0013), GGT ( p < 0.005), @entity650 ( p < 0.021), @entity1851 ( p < 0.0002), and @entity310 ( p < 0.023), between the group with @entity1468 and the group with normal blood pressure. This study also reports a significant association between @entity1851 and systolic blood pressure, diastolic blood pressure, uric acid @entity6571 and @entity3064 (p. CONCLUSION: The inflammatory cytokines, @entity650 , @entity310 and @entity1851 are elevated in @entity1468 and may mediate some of the clinical manifestations of the disorder. A role may exist for anti inflammatory agents in the management of @entity1 with @entity1468 .
