@entity224 radicals and XXXX : are intravascular radicals associated with mortality?

@entity548 @entity7031 @entity224 @entity35 @entity551
@entity224 radicals (SORs) are formed during @entity548 . However, the association between SOR formation and mortality remains undefined. Would neutralization of SORs during shock improve survival? @entity224 dismutase (SOD) was covalently linked to Ficoll to prolong vascular persistence and ensure ongoing neutralization of intravascular SORs. Six groups of @entity35 were studied. @entity35 were exsanguinated to a mean arterial pressure of 30 Torr, sustained for 60 min. Ficoll linked @entity224 dismutase (SOD-F), 5000 Units + catalase, 150 Units, was suspended in 1 ml of saline and injected following the 60-min @entity551 period. Resuscitation followed for appropriate groups. Pretreated SOD-F @entity35 received a 1-ml bolus prior to exsangination. Pretreatment with SOD-F did not improve survival in non-resuscitated groups despite improvement in vascular circulation (P greater than 0.10, @entity7031 ). In the standard non-resuscitation group, there is also no improvement (P greater than 0.10, @entity7031 ). Resuscitation with or without SOD-F significantly alters survival rates (P less than 0.025) with respect to non-resuscitated controls. However, application of SOD-F in conjunction with resuscitation does not improve survival with respect to resuscitation controls (P greater than 0.10, @entity7031 ). Although SOD-F has a vascular half-life advantage over SOD, the improvement in survival is statistically non-significant. Intravascular SORs do not appear to be associated with mortality. SOR release and consequent damage to the vasculature may be preceded by a more significant intracellular damage. Intracellular SOR damage and its association with mortality in @entity548 remains an open issue.
