XXXX is associated with T-cell activation.

@entity1 @entity82 @entity404 @entity2976 @entity2902 @entity298
BACKGROUND: @entity2976 ( @entity2976 ) is an excessive fibrotic response of the peritoneum that may occur after long-term @entity298 ( @entity298 ). The underlying pathophysiology is poorly understood, but involvement of peritoneal inflammatory T helper 1 cells may be pivotal. METHODS: Soluble @entity2902 (sCD25) concentration was measured as a marker for T-cell activation in serum and ascites from @entity2976 @entity1 and various control @entity1 groups. Peritoneal biopsies were stained for the presence of T cells, and T cells isolated from ascites of @entity2976 @entity1 were characterized in detail for differentiation status and cytokine expression. RESULTS: Serum sCD25 concentrations are significantly and specifically increased in @entity2976 @entity1 compared with haemodialysis, @entity298 and predialysis @entity1 . Peritoneal effluent of stable @entity298 @entity1 contains very low levels of sCD25, while sCD25 levels in ascites of @entity2976 @entity1 are high and indicative of local production. In the years preceding the diagnosis of @entity2976 , the serum sCD25 concentrations increased while remaining at stable levels in control @entity298 @entity1 . The peritoneum and ascites of @entity2976 @entity1 showed a significant influx of T cells with relatively increased numbers of @entity404 (+) T cells. These T cells were fully differentiated and displayed a T helper 1 cell type with a pro-inflammatory cytokine profile. CONCLUSIONS: Increased serum sCD25 concentrations and peritoneal lymphocytosis in @entity2976 @entity1 indicate the involvement of activated T cells in the pathophysiology of excessive @entity82 .
