The natural history of chronic XXXX in childhood: a prospective study.

@entity1 @entity5419 @entity277 @entity112 @entity110 @entity775
BACKGROUND: There are few prospective studies on the natural course of chronic @entity110 (CU) in @entity1 . OBJECTIVE: We sought to examine the natural history of CU in @entity1 and to identify predictors for remission. METHODS: @entity1 4 to 15 years of age with CU were investigated with a complete blood cell count, erythrocyte sedimentation rate, antinuclear antibody titer, complement CH50 level, thyroid studies, autologous serum skin test, skin-prick tests, food challenges, and stool examination for parasites. They were considered to be in remission if symptoms did not recur for at least 12 months without medication. RESULTS: In all, 92 @entity1 (53.3% female) with CU were recruited and followed up for a median duration of 4.3 years (range 2.5-5.8 years). @entity775 ( @entity775 ) was identified in 40% of the @entity1 . @entity5419 was found in 8.7% and parasitic @entity277 in 5.4%. Remission rates at 1, 3, and 5  years after the onset of CU symptoms were 18.5%, 54%, and 67.7%, respectively. The remission rate did not differ in @entity775 compared with non- @entity775 . No predictor of CU remission was identified. LIMITATIONS: The basophil @entity112 release assay was not performed. CONCLUSION: @entity1 with CU have a favorable outcome. @entity775 did not have an intractable course.
