Spectral EEG during short-term discontinuation of antiepileptic medication in partial XXXX .

@entity1 @entity410 @entity1315 @entity302
The effect of short-term discontinuation of antiepileptic drugs (AEDs) on spectral analysis of EEG background activity (spectral EEG) was studied in @entity1 undergoing preoperative evaluation for @entity302 surgery. We also wished to clarify whether AED discontinuation would provide lateralizing evidence in spectral EEGs of @entity1 with @entity1315 ( @entity1315 ). Spectral EEGs were performed in 15 @entity1 receiving their regular medication regimen and again after a 1-week period during AED withdrawal. A subgroup of 9 @entity1 who had previously undergone temporal lobectomies ( @entity1315 group) was studied separately. In this group, we evaluated the effect of preceding @entity410 on spectral EEG derived from temporal neocortical areas. In all @entity1 , spectral EEG changes were detected even after a short-term AED withdrawal. The total amount of absolute delta activity was reduced and occipital peak frequency and relative alpha activity were increased as compared with baseline values. In @entity1315 @entity1 with @entity410 occurring < 20 h before the spectral EEG recording, lateralization was correctly identified by the greater amount of absolute delta activity ipsilateral to the epileptogenic focus. @entity302 are accompanied by subtle focal slowing in spectral EEG for a much longer period than has been assumed. In addition, postictal spectral EEG over the temporal lobes may have lateralizing value. Further studies in larger numbers of @entity1 are needed to evaluate the role of spectral EEG in the preoperative evaluation of @entity1 for temporal lobe surgery.
