Pharmacokinetics of the new broad spectrum @entity114 XXXX -2.

@entity1 @entity114 @entity293 @entity71243
1.0 g of the new broad spectrum @entity114 @entity71243 -2 ws given i.m. to volunteers with varying renal function levels. Peak values of 40-50 microgram/ml were commonly observed in serum. The serum half-life was 1.1-1.5 h in normal renal function and increased to 7.0-17.0 h in @entity1 with inulin clearance values of 12-14 ml/min. There was an appreciable lag before apparent absorption. Absorption rates and protein binding were uninfluenced by renal function. The renal clearance of the @entity114 was less than the glomerular filtration rate. This may be due to either chemical instability of the compound such that it is inactivated before assay, or a substantial portion is changed (instability, metabolism) before excretion. A minor adjustment in dosage schedule is necessary in reduced renal function. Even @entity1 with an inulin clearance of 12-14 ml/min have urine concentrations which are of antibacterial interest, at least in acute @entity293 without anatomical or other particular problems.
