[Transfer of XXXX to renal tissues].

@entity1 @entity8 @entity5938 @entity9700 @entity8934 @entity3041 @entity4195 @entity8933 @entity293 @entity526
Serum and renal tissue concentrations of @entity8933 ( @entity8934 ) after intravenous dosing with 1 g were determined in 15 @entity1 with @entity8 . The highest serum concentration of @entity8934 was 105 micrograms/ml 6 minutes after dosing and the lowest concentration was 10.5 micrograms/ml at 170 minutes. The highest renal tissue concentration was 155 micrograms/g and the lowest concentration was 7.46 micrograms/g. There were no correlation between the tissue concentrations and sampling time. Tissue to serum concentration ratios ranged from 0.28 to 5.73. These @entity1 were divided into 3 groups; @entity3041 , normal kidneys and @entity8 according to pyelographic findings. Their renal tissue concentrations were compared with serum concentrations in each group. The tissue concentrations were lower than the serum concentrations in the first group, and were almost the same or higher in the other groups. @entity8934 concentrations in the medulla and the cortex were determined in 5 @entity1 ; and were higher in the medulla in 4 of these @entity1 . @entity293 due to @entity526 , K. pneumoniae, @entity9700 , @entity4195 or @entity5938 was present in 5 of the 25 @entity1 . Intravenous injection of 1 g of @entity8934 provided therapeutically effective concentrations against these @entity293 .
