The pagetoid variant of bladder XXXX in situ A clinicopathological study of 11 cases.

@entity1 @entity2735 @entity5 @entity2225 @entity189 @entity150 @entity5822 @entity1141
Pagetoid @entity189 in situ ( @entity2735 ) is a rare variant of @entity150 that is characterized by an intraepithelial proliferation of large cells arranged singly or in clusters and randomly distributed. These @entity5 deserve recognition and attention, chiefly because they may be overlooked or misdiagnosed as @entity1141 , then causing unsuspected @entity5 recurrence after surgery. We report on the clinicopathological features and immunohistochemical findings of 11 (14.86%) cases of pagetoid @entity2735 in a retrospective study of 74 cases of @entity189 in situ. Most @entity1 were male ( n=10). Their ages ranged from 31 years to 78 years. The lesion can be present with primary ( n=2) or secondary ( n=9) @entity2735 . Pagetoid @entity2735 is usually a focal lesion occurring in a clinical and histological setting of conventional @entity2735 , and these @entity1 essentially have the same progression and survival rates as @entity1 without pagetoid changes and are treated in the same way. In cases with extensive urothelial denudation, pagetoid @entity2735 may be focally present in otherwise normal-looking urothelium, thus alerting the pathologist to search for additional @entity2735 elsewhere in the bladder. Given that primary extramammary Paget disease of the external genitalia and of the anal canal may extend to the bladder and, conversely, some bladder cases of pagetoid @entity2735 may extend to the urethra, ureter, and beyond to the external genitalia, the differential diagnoses between these two entities represent an important therapeutic consideration. Our data suggest that a panel of immunostains including @entity5822 +/ @entity2225 +/TM+ may assist in differentiating urothelial pagetoid @entity2735 from extramammary Paget disease which is known to be @entity5822 +/ @entity2225 -.
