Urothelial XXXX in young adults: Diagnosis, treatment and clinical behaviour.

@entity1 @entity150 @entity5
INTRODUCTION: The aim of the study is to reveal pathologic characteristics and clinical behaviour of @entity1 40 years old or younger diagnosed with and treated for urothelial @entity150 . METHODS: We retrospectively analyzed the clinical and pathologic data of 91 @entity1 , initially diagnosed and treated at our institution from May 1996 to December 2014. @entity5 recurrence was defined as new occurrence of @entity150 at the same or different sites of the bladder. @entity5 progression was defined as an increase in stage or grade in any of the recurrences. RESULTS: The mean age was 33.8 (range: 17-40) years. The pathological examination after transurethral resection revealed 83 (91.2%) @entity1 with non-muscle invasive @entity150 , and 8 (8.8%) @entity1 with muscle invasive @entity150 . According to the distribution of grade, there were 75, 4 and 12 @entity1 with grade 1, grade 2 and grade 3 diseases, respectively. Initial @entity5 staging was: pTa with 40 @entity1 (43.9%), pT1 with 43 @entity1 (47.2%), pT2 with 7 @entity1 (7.6%), and pT3 with 1 @entity1 (1.2%). While 17 (18.6%) @entity1 recurred in the follow-up, 10 (10.9%) @entity1 had progression. There were no differences in recurrence and progression rates in the Ta and T1 stages between groups (p = 0.233, p = 0.511, respectively). CONCLUSION: The risk of progression increased as the number of relapses increased. The clinical behaviour of high-stage and high-grade disease in younger @entity1 is similar to the older group.
