Geographic differences in the incidence of XXXX of @entity3052 ( @entity3052 ) in Spain.

@entity1 @entity2008 @entity854 @entity3052
The incidence of @entity2008 in @entity3052 ( @entity3052 ) differs according to geographical regions in Spain. We analyse 1,271 consecutive @entity1 diagnosed of @entity3052 between 1995 and 2002 in three different regions of Spain: northern, central and southern. There were 624 males (55%) and 505 females (45%). Age ranged between 1 month and 94 years with a median of 61 years. Abnormal karyotypes were observed in 64% of cases. @entity854 as sole cytogenetic changes were detected in 15% of @entity1 , while structural aberrations were present in 28% of cases, and both abnormalities were found in 22% of @entity1 . A significantly higher proportion of t(15;17) was observed in the south of Spain (21.6%) than in the central (17%) or northern regions (12.6%) (p=0.03). By contrast, @entity1 from the south of Spain showed lower incidence of t(8;21) (0%, compared to 1.6% and 3.6% in central and northern areas, respectively, p=0.04). These differences were maintained in the age-adjusted analysis. Trisomy 8 showed similar incidence in southern and central areas, while the incidence in the northern area was lower (14% and 10%, respectively, p=0.04). Other @entity2008 , such as inv(16) or 11q23 rearrangements, were found at similar frequencies in the three regions.
