XXXX with ambiguous features.

@entity1204 @entity1 @entity4309 @entity5 @entity3905 @entity74 @entity14
@entity1204 are a heterogenous group of @entity5 that show variable histologies, @entity74 and clinical outcomes. The idea of rigid distinctions between @entity5 types is appealing to pathologists, gynecologists, researchers and @entity1 , but in a recent study where high grade @entity1204 were reviewed by three experienced gynecologic pathologists, diagnostic agreement about @entity5 type was reached in only approximately one half of cases. In general, biologically and clinically validated diagnostic criteria are lacking for high grade @entity1204 and for those that appear mixed epithelial. Until such criteria are developed, it remains important to define which morphologic patterns convey accurate clinical and biological information and which do not or might not. " @entity1204 with ambiguous features," the focus of this review, are @entity5 with comparatively uninformative morphologic features. Some publications indicate that gland forming and @entity1204 that appear morphologically low grade or ambiguous are really high grade. There are also indications that high grade @entity1204 are biologically heterogeneous and that the morphologic clues we currently use to distinguish one subtype from another fail to correlate with biological data. Many @entity5 that appear morphologically mixed are, in fact, not biologically or clinically confused: most represent biologically "pure" @entity5 with variant morphology. Interesting associations between the presence of @entity4309 ( @entity14 ) and ambiguous morphology have been discussed in the literature. An apparent relationship between morphologic ambiguity and malignant mixed @entity5 ( @entity3905 ) also exists. The identity of some morphologically ambiguous @entity1204 can be elucidated with immunohistochemistry or other ancillary techniques at present, but the nature of many still remains undefined. This review presents the concept of morphologically ambiguous @entity1204 , proposes morphological gold standard diagnostic criteria for @entity5 that are not ambiguous (an effort that helps define @entity5 that are ambiguous), provides a relevant literature review and offers practical guidance for sorting through diagnostically challenging cases.
