Neuroendocrine effects of XXXX in @entity35 .

@entity1 @entity14911 @entity137 @entity2819 @entity35 @entity1063 @entity9734 @entity14912
@entity14911 ( @entity14912 ) is a degradation product of @entity9734 -based fluorochemicals that are used extensively in industrial and household applications. @entity1 and wildlife are exposed to this class of compounds from several sources. @entity137 tests in rodents have raised concerns about potential developmental, reproductive, and systemic effects of @entity14912 . However, the effect of @entity14912 on the neuroendocrine system has not been investigated thus far. In this study, adult female @entity35 were injected intraperitoneally with 0, 1, or 10 mg @entity14912 /kg body weight (BW) for 2 weeks. Food and water intake, BW, and estrous cycles were monitored daily. At the end of treatment, @entity14912 levels in tissues were measured by high-performance liquid chromatography (HPLC) interfaced with electrospray mass spectrometry. Changes in brain monoamines were measured by HPLC with electrochemical detection, and serum @entity2819 and leptin were monitored using radioimmunoassay. Treatment with @entity14912 produced a dose-dependent accumulation of this chemical in various body tissues, including the brain. @entity14912 exposure decreased food intake and BW in a dose-dependent manner. Treatment with @entity14912 affected estrous cyclicity and increased serum @entity2819 levels while decreasing serum leptin concentrations. @entity14912 treatment also increased @entity1063 concentrations in the paraventricular nucleus of the hypothalamus. These results indicate that exposure to @entity14912 can affect the neuroendocrine system in @entity35 .
