Higher urinary excretion of inorganic @entity1391 during early induction chemotherapy predicts a good prognosis in childhood XXXX .

@entity1 @entity981 @entity5405 @entity5 @entity78 @entity3052 @entity1391 @entity414
The rapidity of response to induction therapy is emerging as an important prognostic factor in @entity1 with @entity981 ( @entity981 ) and @entity3052 ( @entity3052 ). Urine inorganic @entity1391 (IP) and @entity414 (UA) may increase in @entity1 with @entity3052 who undergo their induction chemotherapy, owing to the breakdown of @entity5 cells. The crystallization of UA or @entity78 in renal tubules can result in acute @entity5405 (ATLS). Some reports indicate that @entity1 who experience ATLS have a better prognosis than those who do not. We investigated the relationship between urinary IP and UA excretion and treatment outcome in @entity1 with @entity3052 . @entity1 included 93 @entity1 with @entity981 and 31 @entity1 with @entity3052 . Urine samples were collected and measured for the first 3 days of induction chemotherapy. Among @entity1 with @entity981 , urinary IP excretion was significantly higher in @entity1 without relapse than in those with relapse and correlated with long-term outcome. Among @entity1 with @entity3052 , urinary IP excretion was significantly higher in @entity1 without induction failure (IF) than those with IF. We propose that higher urinary IP excretion could be a useful prognostic marker for determining favorable outcomes in @entity1 with @entity3052 .
