Relationship between A-line Autoregressive Index, Spectral Entropy and steady state predicted site-effect effective concentrations at 05-50-95 of XXXX at different clinical endpoints.

@entity1 @entity1875 @entity19264 @entity909
AIM: Target controlled infusion intravenous anesthesia is a growing phenomenon. Nowadays, many anesthesiologists feel the need to monitor depth of anesthesia during total intravenous anesthesia, even though it is not a standard technique worldwide. Spectral Entropy (SE) is a relatively new depth of anesthesia index. The aim of this study was to investigate whether predicted site-effect @entity1875 concentrations, A-line Autoregressive Index (AAI) and SE values are useful for predicting loss of verbal contact (LVC) and @entity909 ( @entity909 ) during steady-state conditions. METHODS: Forty-four @entity1 scheduled for elective major abdominal surgery were recruited. All @entity1 were unpremedicated. A target controlled infusion of @entity1875 was administered using Schnider's pharmacokinetic model. The initial @entity1875 infusion provided a site-effect concentration of 1.0 mcg @entity19264 , and was increased stepwise by 1.0 mcg @entity19264 every 4 minutes until the concentration reached 6.0 mcg @entity19264 . A 4 minute interval was chosen to assure that steady state site-effect concentrations were obtained. AAI, SE and @entity1875 site-effect concentrations were recorded when LVC occurred and also when @entity909 occurred. Population values for predicted site-effect concentrations at the clinical endpoints were estimated and correlated with AAI and SE values. RESULTS: In our study for @entity909 the effect-site concentration to include 90% of @entity1 was 5.85 ?mcg @entity19264 (5.70-5.90) and 3.4 mcg @entity19264 (3.24-3.60) for LVC. In this study, 90% of @entity1 lost verbal contact at an AAI value of 68 (64.6-71.4) and an SE value of 68.2 (66.2-70.2). @entity909 occurred in 90% of @entity1 at an AAI value of 39.2 (37.2-41.1) and an SE value of 40.2 (38.1-41.3). CONCLUSIONS: @entity909 and LVC occur within a defined range of predicted site-effect concentrations. More emphasis should be given to site-effect concentrations. SE and AAI have similar values at different endpoints and similar correlation with Ceprop. AAI and SE are both useful tools in predicting both LVC and @entity909 .
