[Sonographic volumetry of the thyroid gland in the control o thyroxin and XXXX treatment of non-toxic goiter].

@entity1 @entity1496 @entity1955 @entity6893 @entity1378 @entity3214
In a prospective study 39 @entity1 with @entity3214 were treated for one year with 100 micrograms @entity1955 (n = 19) or 500 micrograms @entity6893 (n = 20). Efficacy of treatment was assessed by sonographic thyroid volumetry . In both forms of treatment maximum volume decrease was already seen within the first six months. After treatment for one year the mean decrease of thyroid volumes was 27.5% in the @entity1955 group and 22% in the @entity6893 group. This difference was statistically not significant. There was no difference in the extent of goitre size reduction within the @entity1955 group among @entity1 with complete TSH suppression and with still positive TRH test. Significant increases of T4 and of fT4 values within the normal range were observed already after one month with @entity1955 treatment and only after 3 months with @entity6893 treatment. There were no changes of the T3 values. In one female @entity1 @entity1496 -induced @entity1378 occurred. However, there were no further side effects in both treatment groups. This randomised study documents for the first time that both 500 micrograms of @entity6893 and 100 micrograms of @entity1955 have a comparable efficacy for reduction of goitres.
