T cell receptor gene expression in autoimmune XXXX .

@entity17227 @entity19 @entity12811 @entity12810 @entity3512 @entity1309 @entity792 @entity12813
@entity792 in @entity19 with the @entity1309 / @entity1309 and gld/gld genotypes is accompanied by profound lymphadenopathy characterized by the presence of a massive expansion of an unusual T cell subset. The abnormal lymph node T cells were found to express @entity12813 and @entity12811 transcripts of expected sizes. There was a 10-fold increase in the 1.3-kb @entity12813 transcript and a twofold increase in @entity12811 gene expression, even though @entity3512 expression was in general similar to controls. A study of T cell receptor expression during ontogeny failed to reveal any striking differences between @entity1309 / @entity1309 and congenic @entity19 . There was a strong correlation between @entity12813 expression and @entity17227 expression; however, there was no necessary association of @entity12813 and @entity17227 expression when various T cell lines were examined. Background genes were found to influence the expression of T cell receptor genes in @entity1309 / @entity1309 @entity19 . AKR- @entity1309 / @entity1309 lymph node cells, but not cells from other @entity1309 / @entity1309 @entity19 or AKR +/+ @entity19 , had the predominance of the 1.0-kb @entity12813 transcript, which represents the nonfunctional D-J @entity12813 rearrangements. Lymph nodes from MRL- @entity1309 / @entity1309 @entity19 , but not @entity1309 or AKR- @entity1309 / @entity1309 @entity19 , were found to express small amounts of the @entity12810 gamma transcript. In addition, MRL- @entity1309 / @entity1309 but not C57BL/6- @entity1309 / @entity1309 @entity19 had an age-related decrease in thymic @entity12813 expression along with a decrease in thymic @entity17227 expression. The current study extends the characterization of T cell gene expression abnormalities in peripheral T cells of gld/gld and @entity1309 / @entity1309 and describes certain similarities of these cells to immature thymocytes at a molecular level. Furthermore, it illustrates the complex interactions between "background genes" and genes responsible for lymphoproliferation, which in concert lead to specific molecular and cellular abnormalities.
