Immunological mechanisms in @entity631 . A short review and analysis of peripheral mononuclear cell subsets in XXXX and @entity631 .

@entity1 @entity644 @entity1310 @entity8 @entity19 @entity4755 @entity3450 @entity1985 @entity631
Recent advances in immunology and histological techniques suggest that besides humoral also cellular mechanisms participate in the development of @entity8 . The purpose of this study was to examine whether @entity1 with @entity8 or @entity631 ( @entity631 ) show a disturbance of the immunoregulatory system in the light of peripheral T lymphocyte subset analysis. Mononuclear leukocytes were analysed with monoclonal antibodies (OKT 11, 4 and 8, OKM 1, @entity4755 ). Two categories of findings, depending on the clinical picture, were obtained in both types of @entity1310 . Of 16 @entity8 @entity1 , eight with more serious clinical symptoms had a significantly lower OKT4/OKT8 ratio (mean +/- s.d.: 1.13 +/- 0.37) than controls, p less than 0.01. This was mainly due to an increase of @entity19 positive cells. @entity1 with a mild clinical picture had a normal OKT4/OKT8 ratio. An equally low OKT4/OKT8 ratio (1.22 +/- 0.44) was observed in seven @entity631 @entity1 with @entity1985 range @entity644 . Some of the @entity1 with a high percentage of @entity19 positive cells had a high percentage of @entity4755 positive cells, too. These results suggest disturbed immunoregulation in a group of @entity1 with @entity8 or @entity631 . However, @entity3450 may have influenced results in the @entity631 group. The cause and prognostic significance of the decreased OKT4/OKT8 ratio is uncertain at the present time.
