Role of @entity876 and apoptosis in XXXX .

@entity5 @entity105 @entity74 @entity876
Carcinogenesis is a process that converts normal cells from controllable to uncontrollable growth. Coordinate regulation of the rates of cell proliferation and cell death is an important determinant in maintenance of homeostasis. Loss of control of this balance is central to the development of @entity5 . This loss may be due to @entity74 in either growth promoting genes resulting in constitutive activation or negative growth regulating genes such as @entity5 suppressor genes. Recent advances in studying the molecular mechanisms related to the etiology of @entity5 have provided further understanding of these pathways. Earlier studies have been primarily concerned with cell proliferation resulting from activation of oncogenes. However, many recent studies have focused on the induction of cell death. The recognition of the importance of apoptosis, a distinct mode of cell death, in maintenance of genomic stability was further prompted by studying the mechanism of the @entity5 suppressor gene product @entity876 , as well as many other oncogenes and @entity5 suppressor genes. For example, many oncogenes appear to act as potent inducers of apoptosis through activation of @entity876 dependent apoptosis pathways. Therefore, one possible mechanism for @entity5 suppression involves activation of apoptosis pathways in cells at risk of @entity5 . These studies have provided extensive knowledge of the signal transduction pathways in response to genotoxic stress and promoted mechanistic research related to the apoptosis pathways. These studies also provide a perfect explanation that @entity876 is a key element in maintaining genomic stability and loss of the @entity876 function is a common event during @entity105 . This chapter will mainly focus on the role of apoptosis in @entity105 . In particular, I will summarize recent studies related to the mechanisms of @entity876 and its role in this process.
