Molecular network of important genes for XXXX -related progressive @entity82 .

@entity1 @entity82 @entity641 @entity19 @entity785
BACKGROUND: Considerable progress has been made in illuminating the pathological events for @entity785 ( @entity785 )-related progressive @entity82 . The molecular events that lead to @entity785 -related progressive @entity82 need to be defined. Some important genes have been identified from a recent study in @entity1 . We aim to construct and compare the similarities and differences of molecular pathways between @entity785 -related progressive @entity82 and normal lungs of @entity1 and @entity19 . METHODS: We used the analytical approach of association of key genes in @entity785 -related progressive @entity82 . We first identified the probes for genes of @entity785 -related progressive @entity82 and analyzed the pathways in @entity1 lung using data generated by microarray. We then analyzed the gene pathways in @entity19 lung for similar sets of probes. Gene expression data from livers were used to compare with that in lung in both @entity1 and @entity19 . RESULTS: Our analysis indicated that, in @entity1 , the expression levels of genes for macrophage activation are more strongly associated with each other than that in @entity19 . In both @entity1 and @entity19 , the associations of these genes are much greater in the lung than that in the liver. The association in gene expression between @entity1 and @entity19 are similar for IFN-regulated genes and profibrotic/ @entity641 -regulated genes. CONCLUSION: Our analysis reveals the differences and similarities of the network of key genes between @entity1 and @entity19 during the molecular processes that eventually lead to @entity82 in the lung.
