Weight at birth and subsequent risk of XXXX as an adult.

@entity1 @entity1468
OBJECTIVE: We examined the influence of maternal birth weight on the risk of the development of @entity1468 , a likely precursor to adult chronic disease. STUDY DESIGN: This hospital-based case-control study included 181 @entity1468 cases and 349 control subjects. @entity1 provided information about their birth weight and other covariates that included medical and reproductive history, prepregnancy weight, and adult height. Odds ratios and 95% CIs were estimated by logistic regression. RESULTS: The risk of @entity1468 decreased as maternal birth weight increased (P=.01). After an adjustment was made for confounders, data showed that @entity1 with a low birth weight (<2500 g) had a 2.3-fold increased risk of experiencing @entity1468 (95% CI, 1.0-5.3) as compared with @entity1 who weighed 2500 to 2999 g at birth. Conversely, @entity1 with a birth weight of >/=4000 g appeared to have a nonstatistically significant, but >50%, reduction in the risk of experiencing @entity1468 (95% CI, 0.2-1.2). This relationship differed for lean and overweight @entity1 (body mass index, <25 kg/m(2) vs >/=25 kg/m(2)). Among lean @entity1 , those who were low birth weight had a near doubling in risk of the development of @entity1468 (odds ratio, 1.9; 95% CI, 0.8-4.6), although this association did not reach statistical significance. However, among overweight @entity1 , those @entity1 who weighed <2500 g at birth had an almost 4-fold increased risk of experiencing @entity1468 (odds ratio, 3.8; 95% CI, 1.1-13.8). CONCLUSION: These results confirm two earlier reports and expand the literature by showing that @entity1 who are small at birth and who become overweight as adults are at particularly high risk of the development of @entity1468 .
