The bacteriology of XXXX suppurativa: a systematic review.

@entity1 @entity1751 @entity2348 @entity794 @entity292 @entity1215 @entity272 @entity803 @entity6691 @entity3402
@entity1751 ( @entity1751 ) is a chronic @entity272 consisting of recurrent nodules, sinuses, @entity292 and scarring involving the intertriginous regions. @entity1751 is often a therapeutic challenge and most treatments are off-label. A better understanding of aetiology and pathogenesis of @entity1751 may facilitate the development of effective treatment. Although the clinical presentation is strongly reminiscent of @entity2348 remains controversial. Studies have isolated an array of different bacteria specimens. Consistent findings of Gram-positive cocci and Gram-positive rods including @entity794 , coagulase-negative staphylococci (CoNS) and Corynebacterium species in deep tissue samples have been demonstrated in @entity1751 and may constitute a central target for the immune system. Efficacy of antibiotics, that is @entity1215 , @entity3402 or @entity803 , supports a microbial role in disease pathogenesis. However, these antibiotics also work as immunomodulators of especially T cells, and the underlying mechanisms may therefore be more complex. We performed a systematic review of previous studies investigating the bacterial flora in @entity6691 suppurativa. We searched PubMed, EMBASE, Royal Danish Library and Cochrane library (search date 11 December 2014). A total of 66 papers were identified and nine papers published between 1988 and 2014 matched our inclusion criteria, yielding bacteriological data of a total of 324 @entity1 with @entity1751 (mean age 36.8  years and female/male ratio 215/109). This overview of the bacteriology may aid researchers and physicians exploring the potential role of bacteria in @entity1751 . Furthermore, to stimulate a broader debate, we also present different viewpoints on the possible role of bacteria in @entity1751 .
