The Utility of Diffusion Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) Values in Discriminating Between XXXX and Normal Tissue.

@entity1 @entity263 @entity5 @entity146
BACKGROUND: The aim of this study was to investigate the utility of diffusion weighted imaging (DWI) using Apparent Diffusion Coefficient (ADC) values in discriminating between @entity1 with @entity5 and normal prostate tissue before the initial systematic core biopsy. The relationship between histological grade of @entity263 and ADC values in the peripheral zone was also investigated. MATERIAL/METHODS: Our study included 62 @entity1 who underwent magnetic resonance imaging (MRI) of the pelvis. The examinations were performed in T1-, T2-weighted, DWI and T1 after dynamic contrast administration sequences. In all @entity1 there were abnormal foci within the peripheral zone determined in DWI/ADC. ADC values were compared with the Gleason score (GS) after core needle biopsy (CNB) in @entity1 with low, medium and high stage @entity5 . RESULTS: Within the examined group of @entity1 , ADC was statistically higher for normal tissue than for cancerous tissue (p=0.00). Mean ADC values for @entity1 with low, intermediate and high GS were 0.85  0.03, 0.72  0.03, and 0.61  0.04, respectively. CONCLUSIONS: DWI/ADC is useful in differentiating high-risk @entity1 from those at low and intermediate risk, since there is a significant correlation between ADC values determined in @entity1 included in three different groups according to their Gleason score. This information may be helpful in the assessment of @entity263 @entity146 .
