Making sense of the effects of the cumulative dose of @entity10211 in XXXX .

@entity1 @entity5477 @entity10211
BACKGROUND: The importance of the cumulative dose of @entity10211 with respect to relapse of @entity5477 remains controversial. Although guidelines recommend 0.5-1.0 mg/kg/d to a minimum cumulative dose of 120 mg/kg, there has been a trend toward the use of lower daily dosages with no reference to cumulative dose. OBJECTIVES: This study aimed to determine the influence of daily and cumulative dosage on relapse in acne. METHODS: Charts of @entity1 with acne treated with @entity10211 were reviewed. Demographic details and daily cumulative doses and duration were compared between @entity1 who received one course and two or more courses, respectively. RESULTS: Of 1453 @entity1 , 326 (22.4%) received a second course of treatment (study population). The remainder served as controls (n = 1127). Dosage varied from 10 mg/week to 1.1 mg/kg/d, cumulative dosage from 1 to >300 mg/kg, and duration of treatment from 8 weeks to 5 years. Compared with controls, @entity1 who received a second course were more likely to be @entity1 (61 vs. 47%; P < 0.001) and received higher daily (0.71 vs. 0.58 mg/kg/d; P < 0.001) and cumulative (126 vs. 101 mg/kg; P < 0.001) doses. @entity1 treated with very low doses (e.g. 10 mg three times per week) and/or low cumulative doses (e.g. 25-50 mg/kg) did not relapse more often than controls. CONCLUSIONS: Neither daily nor cumulative dosages influenced relapse of @entity5477 in @entity1 treated with varying doses of @entity10211 as long as treatment was continued for >= 2 months after the acne had completely resolved.
