XXXX in adults.

@entity1 @entity981 @entity706 @entity4195 @entity1778 @entity2008
Clinical and cytogenetic studied were done on 12 @entity1 with @entity981 . The ages of the @entity1 ranged from 17 to 58 years (median, 24.5 years). Males predominated by a ration of 5:1. Ten of the 12 @entity1 had a mediastinal mass at diagnosis; two thirds of the @entity1 had involvement of the bone marrow (3 of 12 @entity1 initially were in a leukemic phase), and 5 of 12 @entity1 had involvement of the central nervous system (CNS) with @entity706 . In all @entity1 , the malignant cells were characterized by nuclear convolutions. Cytogenetic studies done on four @entity1 showed @entity2008 in two cases. Six of the 12 @entity1 were treated with the combination chemotherapy regimen @entity4195 and received CNS prophylaxis; their survival was slightly longer than that of the other @entity1 , who were treated with a variety of treatment regimens. Two of the 12 @entity1 achieved a complete remission. The median survival of all @entity1 was 11.5 months but was shorter in @entity1 with initial CNS involvement or @entity1778 . The poor results achieved thus far in the treatment of this disease demand a new therapeutic approach.
