Early Effect of Bariatric Surgery on the Circadian Rhythms of Adipokines in Morbidly Obese XXXX .

@entity71896 @entity1 @entity1254 @entity28
BACKGROUND: The circadian pattern of adipokines is blunted in @entity28 subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition ( @entity71896 ) surgery on the circadian pattern of leptin, @entity1254 , and resistin in morbidly @entity28 subjects. METHODS: The study group included six morbidly @entity28 @entity1 [body mass index (BMI) 41.3        1.53   kg/m(2)] who underwent @entity71896 and four lean @entity1 (BMI 18.61        0.92   kg/m(2)). Blood from all subjects was collected before and 3 months after bariatric surgery every 6   hr throughout the 24-hr period. The circadian pattern of leptin, @entity1254 , and resistin was measured by enzyme-linked immunosorbent assay or Luminex techniques. RESULTS: Lean @entity1 exhibited rise of plasma leptin levels at nighttime, whereas @entity28 @entity1 had an increase in the overall plasma leptin levels throughout the 24-hr period, lacking the physiological rise of nocturnal leptin levels compared to controls. Obese @entity1 had a decrease in 24-hr @entity1254 levels and similar plasma resistin levels compared to controls. Three months after @entity71896 , @entity28 @entity1 lost 16.0% (P   <   0.005) of their initial body weight and had a decrease in overall 24-hr leptin levels. However, there was no recovery of the nocturnal rise in leptin levels 3 months after @entity71896 . The 24-hr @entity1254 levels were still decreased after @entity71896 surgery compared to controls, while resistin levels were decreased only during night time after @entity71896 . CONCLUSIONS: These results suggested that @entity71896 is an efficient innovative procedure to rapidly decrease 24-hr leptin levels. However, after 3 months, @entity71896 was not enough to recover the physiological nocturnal rise of leptin levels present in lean subjects.
