Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in XXXX with HCC after @entity3375 : Diagnostic Accuracy of 3D Quantitative Image Analysis.

@entity1 @entity3375 @entity39 @entity5 @entity157
Purpose To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment of @entity157 ( @entity157 ) lesions in determining the extent of pathologic @entity39 ( @entity3375 transarterial chemoembolization ). Materials and Methods This institutional review board-approved retrospective study included 17 @entity1 with @entity157 who underwent @entity3375 transarterial chemoembolization before surgery. Semiautomatic 3D three-dimensional volumetric segmentation of target lesions was performed at the last MR examination before orthotopic liver transplantation or surgical resection. The amount of @entity5 tissue on contrast material-enhanced arterial phase MR images and the amount of diffusion-restricted @entity5 tissue on apparent diffusion coefficient ( ADC apparent diffusion coefficient ) maps were expressed as a percentage of the total @entity5 volume. Visual assessment of the extent of @entity5 @entity39 and @entity5 response according to European Association for the Study of the Liver ( EASL European Association for the Study of the Liver ) criteria was performed. Pathologic @entity5 @entity39 was quantified by using slide-by-slide segmentation. Correlation analysis was performed to evaluate the predictive values of the radiologic techniques. Results At histopathologic examination, the mean percentage of @entity5 @entity39 was 70% (range, 10%-100%). Both 3D three-dimensional quantitative techniques demonstrated a strong correlation with @entity5 @entity39 at pathologic examination (R(2) = 0.9657 and R(2) = 0.9662 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively) and a strong intermethod agreement (R(2) = 0.9585). Both methods showed a significantly lower discrepancy with pathologically measured @entity39 (residual standard error [ RSE residual standard error ] = 6.38 and 6.33 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively), when compared with non- 3D three-dimensional techniques ( RSE residual standard error = 12.18 for visual assessment). Conclusion This radiologic-pathologic correlation study demonstrates the diagnostic accuracy of 3D three-dimensional quantitative MR imaging techniques in identifying pathologically measured @entity5 @entity39 in @entity157 lesions treated with @entity3375 transarterial chemoembolization .    RSNA, 2014 Online supplemental material is available for this article.
