XXXX polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events.

@entity1 @entity7744 @entity712 @entity101 @entity583 @entity7743 @entity385
BACKGROUND: The @entity7743 @entity7744 polymorphism has been associated with increased risks of @entity101 and @entity583 in several small studies. We examined the association between this polymorphism and new-onset @entity101 , blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults. METHODS: Eight hundred self-identified African Americans and 1,371 randomly selected white @entity1 in the Cardiovascular Health Study were genotyped. The median duration of follow-up was 8.1 years. RESULTS: The @entity7744 polymorphism was not associated with new-onset @entity101 , with BP control, or with incident cardiovascular events in the overall population. In white @entity1 , the CC genotype was associated with higher baseline systolic BP and pulse pressure, compared to the AC or AA genotype. In whites with treated @entity101 at baseline, compared to the AA genotype, the CC genotype was associated with increased risks of incident @entity712 (hazard ratio = 2.5, 95% confidence interval [CI] 1.3-4.9) and incident @entity385 (hazard ratio = 2.6, 95% CI 1.1-6.0). These associations were not observed among white @entity1 without treated @entity101 , but the interaction of genotype with treated @entity101 on @entity385 and @entity712 was only marginally significant. CONCLUSIONS: On the whole, in this large cohort of older adults, the @entity7744 polymorphism was not associated with BP control or incident cardiovascular events. The subgroup findings in treated @entity101 need to be confirmed in additional studies.
