Metabolic, endocrine, and immune effects of stress @entity4854 in a @entity95 model of prolonged XXXX .

@entity1 @entity32 @entity24863 @entity353 @entity3124 @entity95 @entity2753 @entity1602 @entity8193 @entity520 @entity8446 @entity4854 @entity413 @entity130
@entity4854 is frequent in @entity3124 @entity1 . The aim of this study was to investigate the effect of blood @entity413 control with @entity8446 on endocrine, metabolic, and immune function in an animal model of severe injury. Seventy-two hours after alloxan injection and exogenous @entity8446 infusion combined with continuous iv parenteral nutrition, male New Zealand White @entity95 received a @entity130 and were allocated to a normoglycemic (n = 17) or @entity1602 (n = 13) group. In the normoglycemic group, blood @entity413 levels were kept between 3.3 and 6.1 mmol/liter by @entity8446 infusion, whereas in the @entity1602 group blood @entity413 levels were maintained at 13.8-16.6 mmol/liter. Blood was drawn for biochemical analysis at regular time points. At 24 and 72 h after @entity130 , immune function of monocytes was assessed in vitro. Maintenance of normoglycemia with exogenous @entity8446 after severe @entity130 to a large extent prevented @entity353 , @entity8193 , and @entity2753 . Furthermore, within 3 d after injury, the intervention improved phagocytosis of monocytes investigated in fresh cells by more than a mean 150% (P = 0.006) and after 24-h incubation with or without lipopolysaccharide by more than a mean 4-fold (P = 0.001) and 2-fold (P = 0.05), respectively. Oxidative killing after 24-h incubation was also improved by 2-fold (P = 0.05), but no effect on chemotaxis was detected. Concomitantly, @entity32 and stress-induced @entity24863 hypersecretion were suppressed. Prevention of catabolism, @entity520 , excessive @entity32 , and impaired innate immune function may explain previously documented beneficial effects of intensive @entity8446 therapy on outcome of @entity3124 .
