Association of XXXX synthase gene polymorphisms with wool production and quality traits in Chinese Merino population.

@entity1501 @entity1 @entity742 @entity1255 @entity168 @entity1853 @entity4982
UNASSIGNED: @entity1853 synthase (MTR) plays a crucial role in maintaining homeostasis of intracellular @entity1853 , @entity1501 , and @entity1255 , and its activity correlates with DNA methylation in many @entity1 tissues. Our previous genomewide association study identified that 1 SNP located in the gene was associated with several wool production and quality traits in Chinese Merino. To confirm the potential involvement of the gene in @entity742 wool production and quality traits, we performed @entity742 tissue expression profiling, @entity4982 detection, and association analysis with @entity742 wool production and quality traits. The semiquantitative reverse transcription PCR analysis showed that the gene was differentially expressed in skin from Merino and Kazak @entity742 . The sequencing analysis identified a total of 13 SNP in the gene from Chinese Merino @entity742 . Comparison of the allele frequencies revealed that these 13 identified SNP were significantly different among the 6 tested Chinese Merino strains ( < 0.001). Linkage disequilibrium analysis showed that SNP 3 to 11 were strongly linked in a single haplotype block in the tested population. Association analysis showed that SNP 2 to 11 were significantly associated with the average wool fiber diameter and the fineness @entity168 and that SNP 4 to 11 were significantly associated with the CV of fiber diameter trait ( < 0.05). Single nucleotide polymorphism 2 and SNP 5 to 12 were weakly associated with wool crimp. Similarly, the haplotypes derived from these 13 identified SNP were also significantly associated with the average wool fiber diameter, fineness @entity168 , and the CV of fiber diameter ( < 0.05). Our results suggest that is a candidate gene for @entity742 wool production and quality traits, and the identified SNP might be used in @entity742 breeding.
