The effect of intracoronary fibroblast growth factor-2 on restenosis after primary angioplasty or stent placement in a XXXX model of atherosclerosis.

@entity1 @entity1707 @entity664 @entity301 @entity384 @entity1373 @entity661 @entity1317 @entity453 @entity8233
BACKGROUND: Therapeutic angiogenesis, if combined with primary percutaneous transluminal coronary angioplasty or stent placement, could improve the outcome of @entity1 suffering from multifocal @entity301 . HYPOTHESIS: Because of the concern that angiogenic growth factors might promote restenosis, we studied the effect of a single intracoronary administration of recombinant fibroblast growth factor (rFGF)-2 on restenosis after @entity661 and stent placement in a @entity1707 model of @entity453 . METHODS: In 24 Yucatan minipigs, coronary lesions were induced by @entity1317 and 3 months of atherogenic diet. After 3 months, repeat catheterization was performed with @entity384 or stent placement at the injured sites, with a follow-up of 6 weeks. Results were monitored using quantitative angiography, intravascular ultrasound (IVUS), and histomorphometry. RESULTS: Intracoronary @entity664 2 microg/kg did not affect neointima @entity8233 or remodeling in this model. A small but significant aggravation of late lumen loss was observed in the reference segments of the @entity664 -treated group. Angiographic and echographic late lumen loss, intimal @entity1373 , and arterial remodeling, as well as histologic neointima were all similar in the @entity664 - and the vehicle-treated group. Confirming earlier studies from our group and those of others, stented arteries compared with balloon-dilated arteries had increased angiographic late lumen loss, a trend toward increased intimal @entity1373 and decreased remodeling. CONCLUSION: We conclude that @entity664 does not aggravate restenosis after @entity384 or stenting in this @entity1707 model of @entity453 . Future combinations of angioplasty and therapeutic angiogenesis in a single session should be pursued as a feasible and safe strategy.
