Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing XXXX absorption of experimental hepatofibrotic @entity19 .

@entity4314 @entity19 @entity843 @entity1372 @entity1906 @entity1575
AIM: To observe the regulatory effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating @entity843 in @entity1575 model @entity19 . METHODS: Two Chinese herbal composite prescriptions were used separately to treat the @entity4314 -induced @entity19 model of @entity1575 . The histo-pathologic changes of the liver sections (HE and VG stainings) were observed. The peritoneal lymphatic stomata was detected by scanning electron microscopy and computer image processing. The changes of urinary volume and @entity1372 ion concentration were measured. RESULTS: In the model group, lots of fibrous tissue formed in liver and extended into the hepatic lobules to separate them incompletely. In the treated and prevention groups, the histo-pathologic changes of liver was rather milder, only showed much less fibrous tissue proliferation in the hepatic lobules. The peritoneal lymphatic stomata enlarged with increased density in the experimental groups (diameter: PA, 3.07 +/- 0.69 microm; PB, 2.82 +/- 0.37 microm; TA, 3.25 +/- 0.82 microm and @entity1906 , 2.82 +/- 0.56 microm; density: PA, 7.11 +/- 1.90 stomata.1000 microm(-2); PB, 8.76 +/- 1.45 stomata.1000 microm(-2); TA, 6.55 +/- 1.44 stomata.1000 microm(-2)and @entity1906 , 8.76+/-1.79 stomata.1000 microm(-2)), as compared with the model group (diameter: 2.00+/-0.52 microm density: 4.45+/-1.05 stomata.1000 microm(-2)). After treatment, the urinary volume and @entity1372 ion excretion increased in the experimental groups (PA, 231.28+/-41.09 mmol.L(-1); PB, 171.69 +/- 27.48 mmol.L(-1) and TA, 231.44 +/- 34.12 mmol.L(-1)), which were significantly different with those in the model group (129.33 +/- 36.75 mmol.L(-1)). CONCLUSION: Chinese herbal medicine has marked effects in alleviating @entity1575 , regulating peritoneal lymphatic stomata, improving the drainage of @entity843 from peritoneal cavity and causing increase of urinary volume and @entity1372 ion excretion to reduce the water and @entity1372 retention, and thus have favorable therapeutic effect in treating @entity843 .
