[ XXXX and corticotrophic adenoma: results of pituitary microsurgery].

@entity1 @entity5 @entity699 @entity177 @entity977 @entity86 @entity652
Between November 1994 and June 2001, 194 @entity1 with @entity699 underwent transsphenoidal surgery: 167 @entity1 had adenomectomy, 14 had ante hypophysectomy, 5 had subtotal hypophysectomy, 4 had hemihypophysectomy 4 had central hypophysectomy. Complications occurred in 18 @entity1 (9.3%), including 4 deaths (three were apparently not related to surgery). Remission of disease was achieved in 162 of 190 (85.3%) @entity1 analyzed. @entity177 were associated with lack of @entity977 , size of the @entity5 and invasiveness. Among @entity1 with confirmed @entity652 , the rate of remission was significantly higher (p<0.01) in @entity1 with microadenomas (92.6%) than in @entity1 with macroadenomas (66.7%). Reoperation in 6 failures was followed by remission in 4 cases. The overall remission rate was 87.4%. In the 162 @entity1 with immediate success, duration of follow-up was 10.0 +/- 5.9 years (m +/- DS; median=10.0). Recurrence of the disease occurred in 24 (14.8%) of 162 @entity1 at a mean 4.8 years (range: 0.8-12.0 years). Our longest sustained remission is 25.6 years. Actuarial analysis indicates that the probability of a @entity1 remaining well 12 years after surgery is 80.0%. It is 86.2% in microadenomas versus 52.5% in macroadenomas and 94.5% in the @entity1 with @entity86 versus 59.2% in the others.
