@entity43636 level and the severity of XXXX using cellular and animal models and clinical indices.

@entity1 @entity43636 @entity296 @entity712 @entity82 @entity235 @entity299 @entity67
@entity712 ( @entity712 ) is characterized by @entity296 . A total of 146 @entity1 with @entity712 , were recruited. @entity712 severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). @entity235 modeling of @entity712 was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after pressure loading and myocardial @entity43636 was determined. Mechanical stretch of cultured cardiomyocytes served as the cellular model of @entity712 . @entity1 with severe @entity712 had significantly higher plasma @entity43636 levels. Significant correlation between plasma @entity43636 and E/Em in advanced @entity712 @entity1 was noted. After 2 weeks of pressure overload in @entity235 models, the protein expression of @entity43636 from LV myocardial tissue was significantly increased (p   <   0.01) compared with controls. @entity43636 expression paralleled the severity of LV @entity67 by evaluation of CMRI (r   =   -0.58, p   =   0.003) and tissue @entity82 (r   =   0.59, p   =   0.002). After adjusting for confounders for @entity67 , @entity43636 levels were still associated with diastolic parameters both in @entity1 (p   <   0.001) and @entity235 model (p   =   0.041). Mechanical stretch increased @entity43636 secretion in cultured cardiomyocytes. Both plasma and myocardial @entity43636 levels correlated with severity of @entity299 .
