@entity1378 -induced XXXX : implication in @entity1378 -related @entity712 .

@entity1 @entity712 @entity5691 @entity1378 @entity67 @entity1002
BACKGROUND: @entity712 occurs in 6% of @entity1378 @entity1 . Nonetheless, only half of those with @entity1378 -related @entity712 have @entity1002 . Thus, @entity67 may play an important role in the pathogenesis. METHODS AND RESULTS: We performed serial echocardiographic examinations in 70 consecutive @entity1 with @entity1378 (39    2 years, 47 @entity1 ) to determine their diastolic function and repeated the examinations 6 months after achieving a euthyroid state. All @entity1 had normal LV systolic function, but @entity67 was detected in 22 cases (mild: 3, moderate: 15 and severe: 4). The prevalence of @entity67 increased with age from 17  9 % in @entity1 <40 years to 100% in those >60 years. Increasing age was the only independent predictor for @entity67 in @entity1378 @entity1 . After achievement of a euthyroid state, most @entity1 (16/22, 72%) had completely normalized diastolic function: 100% of @entity1 <40 years, 33  3 % of those >=  60 years. Further analyses revealed significant age-related differences in the cardiovascular response to @entity1378 . Among @entity1 <40 years, @entity1378 resulted in a marked reduction in total peripheral vascular resistance, @entity5691 and enhanced diastolic function as determined by E'. No such significant change in total peripheral vascular resistance or cardiac output was observed in @entity1378 @entity1 >=  40 years. In addition, @entity1378 was associated with reduced E', signifying @entity67 in older @entity1378 @entity1 . CONCLUSION: @entity1378 is associated with @entity67 , particularly in older @entity1 . It is partly reversible following achievement of a euthyroid state.
