Short-term blood pressure variability over 24   h and @entity16 in middle-aged @entity1 and XXXX .

@entity1 @entity101 @entity6 @entity16 @entity4346 @entity15882
UNASSIGNED: Blood pressure variability ( @entity15882 ) has been associated with cardiovascular events; however, the prognostic significance of short-term @entity15882 remains uncertain. As uncertainty also remains as to which measure of variability most accurately describes short-term @entity15882 , this study explores different indices and investigates their relationship with subclinical @entity16 ( @entity16 ). We used data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47-73 years (n=2047). A subsample (1207) underwent 24-h ambulatory BP monitoring (ABPM). As measures of short-term @entity15882 , we estimated the s.d., weighted s.d. (wSD), coefficient of variation (CV) and average real variability (ARV). @entity16 was documented by microalbuminuria and electrocardiogram (ECG) @entity4346 ( @entity4346 ). There was no association found between any measure of @entity15882 and @entity4346 in both unadjusted and fully adjusted logistic regression models. Similar analysis found that ARV (24   h, day and night), s.d. (day and night) and wSD were all univariately associated with microalbuminuria and remained associated after adjustment for age, gender, smoking, body mass index (BMI), @entity6 and antihypertensive treatment. However, when the models were further adjusted for the mean BP the association did not persist for all indices. Our findings illustrate choosing the appropriate summary measure, which accurately captures that short-term @entity15882 is difficult. Despite discrepancies in values between the different measures, there was no association between any indexes of variability with @entity16 measures after adjustment for the mean BP.Journal of @entity1 @entity101 advance online publication, 19 March 2015; doi:10.1038/jhh.2015.18.
