Blood pressure and XXXX : what remains to be achieved?

@entity1 @entity8 @entity101 @entity6 @entity301 @entity65
Despite dramatic improvements in the management of @entity65 , much remains to be accomplished. Arterial stiffness, through its effects on central aortic pressure, is a key determinant of increased cardiovascular risk. Increased pulse pressure is a late manifestation of increased arterial stiffness. What is needed is a simple, reliable, non-invasive method of detecting early disturbances in central artery stiffness at a time when therapeutic intervention can be most beneficial. Currently, intervention studies support initiating antihypertensive therapy in uncomplicated @entity101 when systolic blood pressure > or = 160 mmHg, whereas the benefit of treating systolic blood pressure of 140-159 mmHg, the largest subset of @entity1 with @entity101 , has yet to be tested in controlled trials. Further studies are needed to determine the optimal target goal for blood pressure reduction in both uncomplicated @entity101 and in @entity101 complicated by @entity6 , @entity301 , or @entity8 . Angiotensin converting enzyme inhibitors may provide selective cardiac and renal protection beyond their blood pressure-lowering effect in the presence of specific @entity65 and/or @entity6 . In contrast, there is as yet no definitive answer as to the relative benefit of blood pressure lowering versus specific drug effects in minimizing cardiovascular events in uncomplicated @entity101 . Although there has been a recent increase in @entity101 awareness and treatment, only a small percentage of affected individuals are being treated to goal. @entity65 represents a world-wide public health challenge that can be solved only by new innovative measures aimed at both prevention and treatment.
