HYPOFRACTIONATED RADIOTHERAPY FOR MACROSCOPIC XXXX SOFT TISSUE SARCOMA: A RETROSPECTIVE STUDY OF 50 CASES TREATED WITH A 5 * 6 GY PROTOCOL WITH OR WITHOUT METRONOMIC CHEMOTHERAPY.

@entity1 @entity137 @entity242 @entity235 @entity5 @entity1349
UNASSIGNED: Wide surgical resection or a marginal/incomplete resection followed by full-course radiation therapy is the current standard of care for @entity235 soft tissue @entity242 . The purpose of this retrospective, descriptive, bi-institutional study was to determine the effectiveness and @entity137 of a hypofractionated 5  *  6 Gy protocol on macroscopic @entity235 soft tissue @entity242 in terms of progression-free interval (PFI) and @entity1349 ( @entity1349 ), and to identify prognostic factors for @entity1 outcome. @entity235 with @entity242 irradiated with 5 * 6 Gy were eligible for the study. @entity1349 were compared with respect to different @entity5 and @entity1 characteristics by the Kaplan-Meier method and multivariable Cox regression analysis. Fifty @entity235 with macroscopic disease were included. All @entity235 received the same radiation therapy protocol; part of the group (n = 20) received postradiation metronomic chemotherapy. Median PFI for all cases was 419 days (95% confidence interval (CI): 287-551) and median @entity1349 was 513 days (95% CI: 368-658). @entity235 with @entity5 on the limbs had significantly longer PFI and @entity1349 , compared with head or trunk. Increasing @entity5 burden decreased @entity1349 . The addition of metronomic chemotherapy yielded a significantly longer @entity1349 (757 days (95% CI: 570-944) compared with @entity235 that did not receive systemic treatment (286 days (95% CI: 0-518), (P = 0.023)), but did not influence progression-free interval. @entity137 was low throughout all treatments. The 5 * 6 Gy radiation therapy protocol was well tolerated and provided long PFI and @entity1349 in @entity235 with @entity242 .
