Polymorphism at codon 72 of XXXX , @entity1082 , and @entity5 in South India.

@entity5 @entity1083 @entity2622 @entity534 @entity876 @entity3799 @entity1799 @entity1082 @entity369
PURPOSE: It has been suggested that host genetic factors play a role in @entity1082 )-associated tumorigenesis, although the issue continues to be a focus of much debate. Previous studies have reported that a common polymorphism of the wild type @entity876 gene at codon 72 of exon 4 ( @entity534 / @entity534 ) is associated with a sevenfold increased risk of HPV-associated @entity5 compared to @entity534 /Pro and Pro/Pro polymorphisms. In vitro studies also suggested that the @entity534 / @entity534 polymorphism was much more susceptible to @entity1799 E6-mediated degradation as compared to other allelic forms. Subsequent studies published since this initial report indicated geographical differences with respect to the role of @entity534 / @entity534 polymorphism in increasing the risk of @entity5 . METHODS: In this study we analyzed leukocyte DNA from a total of 421 subjects for the @entity534 / @entity534 , @entity534 /Pro or Pro/Pro @entity876 polymorphisms at various stages of the cervical @entity5 progression spectrum, using allele-specific PCR. All subjects were from the Thiruvananthapuram District of South India. HPV genotyping was done for all subjects using either DNA extracted from cervical biopsies or exfoliated cervical cells. All subjects were grouped on the basis of both of cyto-pathology and HPV status. RESULTS: The distribution of @entity876 genotypes was not significantly different in all study groups (HPV positive vs HPV negative and cases vs controls comparisons). Homozygosity for @entity534 / @entity534 was not associated with increased risk for @entity5 . CONCLUSION: We find no evidence for any association between homozygosity for @entity876 @entity369 with either @entity3799 , @entity2622 or @entity1083 in the population from South India.
