Impaired XXXX downscaling in @entity75 with @entity159 during sleep (ESES).

@entity1 @entity410 @entity25 @entity75 @entity73 @entity159
OBJECTIVE: " @entity75 related to electrical @entity159 during @entity25 " (ESES) is characterised by the electroencephalographic pattern of continuous spike waves during @entity25 (CSWS) and variable @entity73 . The synaptic homeostasis hypothesis predicts that the strength of synapses is decreased during sleep. The slope of slow waves during NREM sleep best reflects this "downscaling". METHODS: In a retrospective case control study, we analysed the time course of the slope of EEG slow waves of nine @entity1 with ESES. The @entity1 showed continuous spike waves (>85%) associated with regression or stagnation of cognitive functions. The data of the @entity1 group were compared to nine healthy age and gender matched controls. RESULTS: In control subjects we found the expected decrease of the slope of slow waves from the first to the last hour of sleep (17.2% decrease, p<0.001). In contrast, @entity1 showed no significant change in slope across the night. CONCLUSIONS: This finding may reflect a disruption of the downscaling process during sleep, which may contribute to the developmental regression in these @entity1 . SIGNIFICANCE: Thus, our findings contribute to the understanding of the pathomechanisms leading to the regression observed in @entity1 with ESES and support the view that the goal of the treatment in @entity1 with ESES should not only be to reduce @entity410 , but also to resolve the continuous spike wave activity.
