Long-term exposure to black XXXX , cognition and single nucleotide polymorphisms in microRNA processing genes in older @entity1 .

@entity1 @entity11778 @entity73 @entity10405 @entity70794 @entity60721 @entity58556 @entity505 @entity70795 @entity21178 @entity26365 @entity70793
INTRODUCTION: Air pollution exposure has been linked to @entity73 , but little is known about biomarkers modifying this association. MicroRNAs (miRNAs) control gene expression and neuronal programming. miRNA levels vary due to single nucleotide polymorphisms (SNPs) in genes processing miRNAs from precursor molecules. OBJECTIVES: To investigate whether SNPs in miRNA-processing genes are associated with cognition and modify the relationship between black @entity505 (BC), marker of traffic-related pollution, and cognitive functions. METHODS: 533 Normative Aging Study @entity1 (mean  SD 72  7years) were tested  <=4 times (mean=1.7 times) using seven cognitive tests between 1995 and 2007. We tested interactions of 16 miRNA-related SNPs with 1-year average BC from a validated land-use-regression model. We used covariate-adjusted logistic regression for low ( <=25) Mini-Mental tate Examination (MMSE) and mixed-effect regression for a global cognitive score combining six other tests. RESULTS: Global cognition was negatively associated with the homozygous minor variant of @entity70793 @entity21178 (-0.42SD; 95%CI: (-0.71, -0.13)) relative to the major variant. BC-MMSE association was stronger in heterozygous carriers of @entity11778 @entity10405 (OR=1.99; 95%CI: (1.39, 2.85)) and minor variant carriers of @entity58556 @entity70794 (OR=1.34; 95%CI: (1.05, 1.7)), compared to their major variant. The BC-global-cognition association was stronger in heterozygous carriers of @entity58556 @entity60721 (-0.10SD; 95%CI: (-0.18, -0.02)), and @entity58556 @entity70795 (-0.09SD; 95%CI: (-0.17, -0.02)) relative to the major variant. Blood miRNA expression analyses showed associations only of @entity10405 @entity11778 with miR-9 and @entity26365 . CONCLUSIONS: Carriers of particular miRNA-processing SNPs had higher susceptibility to BC in BC-cognition associations, possibly due to influences on miRNA expression.
