Comparative study between tissue-engineered periosteum and structural allograft in XXXX critical-sized radial defect model.

@entity3124 @entity95 @entity25288 @entity79 @entity236
The purpose of this study was to compare the efficacy of tissue-engineered periosteum ( @entity25288 ) to allgeneic bone in @entity79 . @entity25288 was fabricated with osteoinduced @entity95 bone marrow mesenchymal stem cells (MSCs) and porcine small intestinal submucosa (SIS). Allogrfats were cryopreserved radial segments of @entity95 . Forty-eight radial @entity3124 ( @entity3124 ) were bilaterally produced in 24 @entity95 . The defects were divided into three groups, group A, @entity25288 implantation, group B, SIS implantation, and group C allograft. Bone defect reconstruction was kinetically analyzed at 4, 8, and 12 weeks by radiographic and histological scoring system. In group A, @entity79 were radiographically and histologically healed with mature cortex and @entity236 by 12 weeks, while none of the defects healed in group B. Group C showed a slow process of creeping substitution with lymphocyte infiltration. Statistical comparison confirmed that group A had a more efficient and rapid bone defect reparation as well as remodelling than Group B and C. In conclusion, @entity25288 is superior to structural allograft in reconstruction of @entity79 . Pure SIS cannot guide bone regeneration in this @entity95 model.
