Cellular distribution of angiotensin-converting enzyme after XXXX .

@entity1 @entity82 @entity35 @entity1563 @entity1188 @entity1811 @entity583
We studied the cellular distribution of angiotensin-converting enzyme ( @entity1811 ) in the heart related to the cell types involved in left ventricular repair and remodeling before and after @entity583 by immunohistochemical techniques using monoclonal and polyclonal antibodies. In noninfarcted myocardium of both @entity1 and @entity35 , @entity1811 expression was confined to endothelial cells and subendocardial cell layers of the aortic valve. @entity1811 was prominent in endothelia of small arteries and arterioles, whereas only half the coronary capillaries were immunoreactive and venous vessels were almost completely devoid of the enzyme. In a @entity35 model of @entity583 , @entity1811 distribution was determined 1, 3, and 7 days and 2, 3, and 6 weeks after @entity1563 . Three and 7 days after @entity1188 , endothelial cells of sprouting capillaries and macrophages in the marginal zone of necrosis revealed @entity1811 expression. In both @entity1 and @entity35 with the onset of @entity82 , intense staining of the enzyme was found in the marginal zone of the repair tissue. In situ hybridization for collagen type I in the @entity35 revealed that zones with high collagen content had almost no @entity1811 immunoreactivity. Vascular smooth muscle cells and cardiomyocytes revealed no @entity1811 expression throughout the study. We conclude that endothelial cells are the principal source for the expression of @entity1811 after @entity583 . The observed induction of @entity1811 with the onset of @entity82 suggests a role of this enzyme that is related to tissue repair and remodeling.
