An outbreak of severe XXXX due to @entity14536 in a long-term care facility.

@entity1 @entity14536 @entity281 @entity5924 @entity683 @entity1729
BACKGROUND: @entity14536 ( @entity14536 ) is a newly described paramyxovirus that is mainly associated with @entity5924 in @entity1 . We sought to describe the epidemiological, virological, and histopathological findings associated with a large outbreak of @entity14536 @entity281 in a long-term care facility. METHODS: An investigation of the outbreak was performed by public health authorities, who used standardized questionnaires to collect relevant clinical information from all residents of the facility. Nasopharyngeal samples were obtained from a subset of @entity1 who had @entity683 -like illnesses for testing by viral culture and reverse-transcriptase polymerase chain reaction. Lung tissue samples from a @entity1 whose case was fatal were available for molecular, histopathological, and immunohistochemical testing. RESULTS: A total of 96 (27%) of 364 residents of a long-term care facility presented with respiratory or constitutional symptoms between 1 January 2006 and 15 February 2006. The attack rate in the most affected ward was 72% (31 of 43 @entity1 ), which included 4 of the 6 polymerase chain reaction-confirmed cases of @entity14536 @entity281 . In contrast, viral culture results were positive for @entity14536 in only 2 of the 5 polymerase chain reaction-positive samples tested. The most reported diagnosis was an @entity1729 or an @entity683 -like illness, although 21% of residents in 1 of the 3 wards that had confirmed cases of @entity14536 @entity281 had lower respiratory tract @entity281 . The fatality rate was 50% (3 of 6 @entity1 ) among confirmed cases and 9.4% (9 of 96 @entity1 ) among @entity1 with possible cases. A @entity1 with a fatal case had histopathological findings that confirmed the presence of @entity14536 RNA and proteins in the bronchiolar epithelium of affected lobes. Phylogenetic analysis revealed the presence of 2 distinct strains of @entity14536 circulating simultaneously on different wards. CONCLUSION: @entity14536 can be associated with important outbreaks of acute @entity1729 in elderly institutionalized @entity1 .
