Smoke or fire? Acute XXXX and the liraglutide trials.

@entity788 @entity6 @entity4053 @entity8142 @entity413
Over the past few years, substantial clinical data have been presented showing that incretin-based therapies are effective @entity413 -lowering agents. Specifically, @entity8142 agonists demonstrate an efficacy comparable to insulin treatment with minimal @entity4053 and have favorable effects on body weight. Thus, many of the unmet clinical needs noted from prior therapies are addressed by these agents. However, even after many years of use, many continue to raise concerns about the long-term safety of these agents and, in particular, the concern with @entity788 . This clearly remains a complicated topic. Thus, in this issue of @entity6 Care, we continue to update our readers on this very important issue by presenting two studies evaluating incretin-based medications and risk of @entity788 . Both have undergone significant revisions based on peer review that provided significant clarification of the data. We applaud both author groups for being extremely responsive in providing the additional data and revisions requested by the editorial team. As such, because of the critical peer review, we feel both articles achieve the high level we require for @entity6 Care and are pleased to now present them to our readers. In keeping with our aim to comprehensively evaluate this topic, we asked for additional commentaries to be prepared. In the narrative outlined below, Prof. Edwin A.M. Gale provides a commentary on the report that focuses on clinical trials of liraglutide in the treatment of @entity6 . In the narrative that follows Prof. Gale's contribution, Dr. Laurent Azoulay provides a commentary about the remaining uncertainty in this area and also discusses the results from a nationwide population-based case-control study. From the journal's perspective, both of the articles on @entity788 and incretin-based therapies reported in this issue have been well vetted, and we feel both of the commentaries are insightful.
