Auricular vagal nerve stimulation ameliorates burn-induced @entity356 via sympathetic- XXXX pathways in @entity35 .

@entity1169 @entity1819 @entity35 @entity4665 @entity1063 @entity356 @entity130
BACKGROUND: Severe @entity130 has been demonstrated to delay @entity356 . The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced @entity356 in @entity35 . METHODS: @entity1169 (b-adrenoceptor antagonist) was injected intraperitoneally after the @entity35 underwent @entity130 . All experiments were performed 6 h following burn/sham @entity130 . AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; @entity4665 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. KEY RESULTS: (i) @entity130 delayed @entity356 (p = 0.006) and AEA increased @entity356 by 49% (p = 0.045). (ii) @entity130 evoked a significant elevation in plasma @entity1063 , which was suppressed by AEA. (iii) @entity130 significantly increased protein and mRNA expressions of @entity4665 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of @entity4665 . CONCLUSIONS _ INFERENCES: Burn @entity1819 by up-regulating @entity4665 attributed to sympathetic overactivity. AEA improves burn-induced delay in @entity356 , possibly mediated via the sympathetic- @entity4665 pathway.
