Progressive Resistance Exercise Training in XXXX : A Feasibility Study.

@entity2086 @entity1 @entity1009 @entity740
BACKGROUND: Skeletal muscle wasting in @entity740 ( @entity740 ) is associated with morbidity and mortality. Resistance exercise results in @entity2086 in the healthy population, but is underinvestigated in @entity740 . We aimed to determine the feasibility of delivering a supervised progressive resistance exercise program in @entity740 , with secondary aims to investigate effects on muscle size, strength, and physical functioning. STUDY DESIGN: Parallel randomized controlled feasibility study. SETTING _ @entity1 : @entity1 with @entity740 stages 3b to 4 were randomly assigned to the exercise (n=20; 11 @entity1 ; median age, 63 [IQR, 57-65] years; median estimated glomerular filtration rate, 28.5 [IQR, 19.0-32.0] mL/ @entity1009 .73 m(2)) or nonexercise control (n=18; 14 @entity1 ; median age, 66 [IQR, 45-79] years; estimated glomerular filtration rate, 20.5 [IQR, 16.0-26.0] mL/ @entity1009 .73 m(2)) group. INTERVENTION: @entity1 in the exercise group undertook an 8-week progressive resistance exercise program consisting of 3 sets of 10 to 12 leg extensions at 70% of estimated 1-repetition maximum thrice weekly. @entity1 in the control group continued with usual physical activity. OUTCOMES: Primary outcomes were related to study feasibility: eligibility, recruitment, retention, and adherence rates. Secondary outcomes were muscle anatomical cross-sectional area, muscle volume, pennation angle, knee extensor strength, and exercise capacity. MEASUREMENTS: Two- and 3-dimensional ultrasonography of skeletal muscle, dynamometry, and shuttle walk tests at baseline and 8 weeks. RESULTS: Of 2,349 @entity1 screened, 403 were identified as eligible and 38 enrolled in the study. 33 (87%) completed the study, and those in the exercise group attended 92% of training sessions. No changes were seen in controls for any parameter. Progressive resistance exercise increased muscle anatomical cross-sectional area, muscle volume, knee extensor strength, and exercise capacity. LIMITATIONS: No blinded assessors, magnetic resonance imaging not used to assess muscle mass, lack of a healthy control group. CONCLUSIONS: This type of exercise is well tolerated by @entity1 with @entity740 and confers important clinical benefits; however, low recruitment rates suggest that a supervised outpatient-based program is not the most practical implementation strategy.
