@entity282 and systemic inflammatory stress response after preoperative analgesia with XXXX or @entity1343 : a randomized controlled trial.

@entity1 @entity650 @entity1904 @entity1343 @entity158 @entity1338 @entity282
AIM: With adequate control of perioperative @entity158 it is possible to control central and peripheral inflammatory responses to surgery and influence @entity1 outcomes. Use of analgesics before the @entity158 stimulus (preventive analgesia) obstructs development of neuroplastic changes in the central nervous system and reduces @entity158 . Our investigation hypothesis is that preoperative central (epidural or intrathecal) @entity1338 will reduce @entity282 and the systemic inflammatory stress response more effectively than @entity1343 . DESIGN: Randomized controlled study. METHODS: Forty-two @entity1 undergoing colorectal resection surgery were allocated into three groups receiving a preoperative epidural dose of (i) @entity1338 5 microg/kg (n = 17), (ii) @entity1343 2.5 mg/ml (n = 12) or (iii) saline as a control group (n = 13). @entity1904 , @entity650 and @entity158 levels were assessed before operation, 1 h after starting, and then at 1, 6, 12 and 24 h after operation. RESULTS: There were no significant differences between the groups of @entity1 in age, sex, body-mass index, body surface area and operation time. We demonstrated significant reduction (P < 0.05) in levels of @entity1904 and @entity650 in the preoperative @entity1338 group compared with the preoperative @entity1343 and control groups. @entity282 levels at rest and on movement were significantly lower (P < 0.05) in the @entity1338 group, especially 1 h after surgery (VAS 0.82 and 1.18), than in the @entity1343 group (VAS 5.25 and 6.67) and the control group (VAS 7.08 and 8.31). CONCLUSION: These results support the importance of the central effect of @entity1338 on @entity158 pathways and blockade of the systemic inflammatory stress response.
