Interaction of carotid chemoreceptor and baroreceptor reflexes in anesthetized XXXX .

@entity4485 @entity4095 @entity235 @entity515
Interaction between baroreceptors and chemoreceptors during simultaneous activation of the reflexes was studied in eight @entity4485 -anesthetized vagotomized @entity235 . The carotid sinus reflexogenic area was isolated and perfused at controlled carotid sinus pressure (CSP), @entity4095 , and PCO2. Random combinations of CSP, @entity4095 , and PCO2 were delivered to the carotid sinus. Results were analyzed by multiple linear regression. For the arterial pressure response, increasing @entity515 resulted in an upward shift of the baroreceptor reflex response curve and an increased slope of the linear portion of the curve. The heart rate-CSP curve was also shifted upward by @entity515 , with the effect being greatest at high levels of CSP. The respiratory frequency- @entity515 relationship had an increased slope and was shifted upward when CSP was decreased. The responses of tidal volume and ventilation (VE) depended on all three inputs. At any level of @entity4095 , decreasing CSP resulted in a parallel shift of the VE- @entity515 relationship. The results indicate that there is a significant interaction between chemoreceptor and baroreceptor reflex sensitivities.
