Antioxidant status in XXXX and role of antioxidant therapy.

@entity1 @entity1433 @entity3145 @entity620 @entity1865 @entity26 @entity2041 @entity1234 @entity309
BACKGROUND: @entity26 free radicals have been implicated as mediators of @entity3145 in @entity1 of @entity309 ( @entity309 ). This study was designed to elucidate plasma oxidant/antioxidant status in @entity309 , with the aim of evaluating the importance of antioxidant therapy in the management of this disease. METHODS: The study included 40 @entity1 of @entity309 who were randomly divided into two subgroups of 20 each. One group received conventional treatment for 12 weeks and in the other group conventional treatment was supplemented with antioxidants for the same duration. Twenty age- and sex-matched normal individuals constituted the control group. Blood samples of controls and @entity1 were collected at the time of presentation and analyzed for total @entity1433 , @entity2041 , @entity620 and @entity1234 ( @entity1865 -marker of oxidative stress). The investigations were repeated in the @entity1 after 12 weeks. RESULTS: The blood concentrations of total @entity1433 , @entity2041 and @entity620 were found to be significantly lower in @entity309 @entity1 as compared to healthy controls, while the concentrations of @entity1865 were much higher. There was a statistically significant increase in the posttreatment concentrations of these antioxidants, along with a decrease in the concentrations of @entity1865 . CONCLUSIONS: The antioxidant defense system is compromised in @entity309 @entity1 . There is a shift in the oxidant/antioxidant balance in favor of lipid peroxidation, which could lead to the @entity3145 observed in the disease. The results suggest the necessity for therapeutic co-administration of antioxidants along with conventional drugs to such @entity1 . However, due to the limited number of cases included in this study, more studies may be required to substantiate the results and arrive at a definite conclusion, in terms of safety and efficacy of adding on antioxidant therapy for the treatment of @entity309 .
