[Analysis of heart rate as a risk factor associated with the progression of XXXX ].

@entity1 @entity644 @entity8 @entity101 @entity6 @entity177 @entity1011 @entity551 @entity65
BACKGROUND: An increased heart rate is associated with an increased risk of @entity65 . However, the possible relationship between heart rate and the rate of progression of @entity8 has not been assessed so far. @entity1 AND METHOD: Twenty-four-hour ambulatory blood pressure and heart rate recordings at baseline conditions were obtained in 24 @entity1 with non- @entity6 @entity177 and @entity101 . The rate of progression of @entity8 was estimated on the basis of the slope of the reciprocal of serum @entity1011 concentration against time. RESULTS: After a mean follow-up of 38 months, the rate of progression of @entity177 was 0.004 (0.039) dL/mg/month. Progression of @entity8 showed no correlation with baseline ambulatory @entity551 , and did not differ between dipper and non-dipper @entity1 . Twenty-four-hour (r = 0.40, p = 0.05) and day-time (r = 0.534, p = 0.007) heart rates showed a relationship with the progression of @entity177 . @entity644 displayed a correlation with night-time heart rate (r = 0.405, p = 0.05) but not with the progression of @entity177 . CONCLUSIONS: Baseline ambulatory heart rate, especially day-time heart rate, is associated with the decline of renal function in non- @entity6 @entity1 with @entity177 , suggesting that heart rate is a risk factor (or marker) for @entity8 . Prospective controlled studies with a larger sample of @entity1 are needed to confirm these findings and to investigate the possible mechanisms involved in this association.
