Natural history of behavioural changes and @entity146 symptoms in XXXX . A longitudinal study.

@entity1 @entity146 @entity303 @entity73 @entity195 @entity204
BACKGROUND: @entity195 and other types of @entity303 are characterised by numerous @entity146 and behavioural changes. Little is known of their natural history. AIMS: To investigate the sequence and pattern of these changes throughout the course of @entity303 . METHOD: One hundred @entity1 , initially living at home with carers, entered a prospective, longitudinal study. At four-monthly intervals, behavioural and @entity146 symptoms were assessed using the Present Behavioural Examination and Mini-Mental State Examination. Follow-up continued for up to nine years (mean 3.3 years; s.d. 2.4). Patterns of onset and disappearance of these symptoms, their sequence and association with time of @entity204 and @entity73 were analysed. Autopsy confirmed a diagnosis of pure @entity195 in 48 subjects. Data for this subgroup are presented. RESULTS: Some changes tend to occur earlier than others but changes can occur at almost any time in the course of @entity303 . CONCLUSIONS: The natural history of behaviour changes in @entity195 shows great individual variation although some changes tend to follow a recognisable sequence.
