Seroprevalence, correlates, and characteristics of undetected XXXX in England.

@entity1 @entity64 @entity66 @entity417 @entity68826 @entity170 @entity10208 @entity460 @entity299 @entity165
OBJECTIVE: To examine the seroprevalence, correlates, and characteristics of undetected @entity66 in a large adult population sample in Cambridge, UK. METHODS: The Cambridge General Practice Health Study invited individuals from 12 general practices, aged 45-76 years, to attend for a health survey that included a bone density measurement, between 1990 and 1995. A total of 7550 participants' serum samples were tested for antiendomysial antibody ( @entity10208 ). Seroprevalence of undetected @entity66 was based on @entity10208 positivity. Differences between @entity10208 positive and negative @entity1 of various physiological correlates and reported characteristics were estimated by multivariate logistic and linear regression and adjusted for age, sex, social class, and smoking behaviour. RESULTS: The seroprevalence of undetected @entity66 in this general population sample aged 45-76 was 1.2% (95% confidence interval (CI) 0.9-1.4). @entity10208 positive @entity1 (n=87) were on average slightly lighter by 2.2 kg (p=0.08), were more likely to have reported their general health as being "good or excellent" ( @entity68826 (95% CI 0.90-3.46)), and were less likely to report being a current smoker (OR for current versus never 0.36 (95% CI 0.14-0.90)) than @entity10208 negative @entity1 . @entity10208 positivity was associated with an 8% reduction in mean serum @entity165 (0.5 mmol/l; p<0.01) and reductions in mean haemoglobin (0.3 g/dl; p<0.01), total protein (1.0 g/l; p<0.05), and corrected serum @entity460 (0.02 mmol/l; p<0.05). There was an increased risk of @entity170 in @entity10208 positive @entity1 (OR 3.1 (95% CI 1.3-7.2)) and of mild @entity417 (OR 4.6 (95% CI 2.5-8.2)) compared with @entity10208 negative @entity1 . CONCLUSIONS: Undetected @entity66 is likely to affect approximately 1% of the population of England aged 45-76 years, a value similar to several other countries. Those affected report "better health" but they do have an increased risk of @entity170 and mild @entity417 . In contrast, they have a favourable cardiovascular risk profile that may afford protection from @entity299 and @entity64 .
