@entity1457 proteins @entity2284 , XXXX , @entity2285 , and @entity4041 : expression in @entity150 .

@entity1 @entity4041 @entity2284 @entity5 @entity1457 @entity2285 @entity189 @entity150 @entity11090 @entity105 @entity11217
BACKGROUND: @entity1457 proteins (HSPs) are synthesized by cells in response to various stress conditions, including @entity105 . The expression of HSPs in @entity5 has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of @entity150 and their effect on @entity5 behavior. METHODS: Expression levels of the 27-kilodalton @entity2284 ( @entity2284 ), @entity11217 , @entity2285 , and @entity4041 were studied using immunohistochemistry on tissue sections from 42 transitional cell @entity189 of the bladder (14 Grade 1 @entity5 ; 13 Grade 2 @entity5 ; 15 Grade 3 @entity5 , including 3 @entity5 associated with @entity189 in situ; 30 Stage Ta @entity5 ; 7 Stage T1 @entity5 ; and 5 Stage T2 @entity5 ). Bladder specimens from 10 healthy @entity1 were used as controls in the study. The selected @entity1 had a mean follow-up of 52 months (range, 24-78 months). Among the 37 @entity1 with superficial @entity150 , 17 @entity1 did not have any recurrence after undergoing primary resection, and 20 @entity1 developed recurrent disease, including 4 recurrences with @entity11090 . @entity2284 expression was evaluated according to the percentage of positively stained cells, and loss of expression was defined as < 80% of stained cells. RESULTS: In normal bladder specimens, all four HSPs ( @entity2284 , @entity11217 , @entity2285 , and @entity4041 ) were expressed strongly in the cytoplasm and membrane from the basal cell layer to the superficial cell layer. Loss of expression was detected in @entity5 : respectively, 45.2%, 38.1%, 69.0% and 23.8% of @entity5 showed a loss of immunostaining for @entity2284 , @entity11217 , @entity2285 , and @entity4041 . No correlation between @entity2284 expression and grade was found. Low expression levels of @entity2284 and @entity11217 were correlated with higher @entity5 stage (87% vs. 6% [P < 0.001] and 78% vs. 9% [P < 0.01], respectively). @entity11217 and @entity4041 expression levels were correlated with final outcome for @entity1 with superficial @entity150 : loss of expression was associated with the risk of developing an infiltrating recurrence (97% vs. 6.0% [P < 0.001] and 88.2% vs. 52.5% [P = 0.02] for @entity11217 and @entity4041 , respectively). CONCLUSIONS: HSPs were expressed in normal urothelium, and the current results indicated that loss of @entity11217 and @entity4041 expression may have prognostic relevance in @entity1 with @entity150 . The authors believe that @entity11217 may be a very useful marker for @entity1 with superficial @entity150 and may be used for predicting disease progression. If these data are confirmed, low @entity11217 expression levels may be usable as a prognostic marker to identify @entity1 for whom local treatment would be insufficient.
