Family history of severe @entity65 in XXXX is associated with increased aortic diameter and decreased survival.

@entity1 @entity384 @entity1614 @entity204 @entity65
OBJECTIVES: We attempted to determine whether a family history of severe @entity65 in @entity1 with the @entity1614 is associated with @entity384 or decreased survival, or both. BACKGROUND: The prognostic importance of a family history of severe @entity65 in @entity1 with the @entity1614 has been incompletely examined. We hypothesized that such a family history would correlate with @entity384 and would be associated with decreased survival. METHODS: One hundred eight affected @entity1 and 48 unaffected family members from 33 multigenerational families with the @entity1614 underwent echocardiographic measurement of the aortic root, arch and mid-abdominal aorta. Date of birth and age at @entity204 ascertained from family pedigrees were used to perform life table analysis and estimate survival. RESULTS: Aortic root and arch diameters were significantly greater in @entity1 with a family history of severe @entity65 than in @entity1 without such a family history. Of subjects in the highest quartile for aortic size, > 80% had such a family history in contrast to < 10% of those in the lowest quartile (chi-square 57.37, p < 0.00001). Mean age at @entity204 and cumulative probability of survival were significantly lower in @entity1 with such a family history. CONCLUSIONS: Among @entity1 with the @entity1614 , @entity384 is greater and life expectancy shorter in those with a family history of severe cardiovascular manifestations. These data suggest that such a family history is an important risk factor for cardiovascular events in @entity1 with the @entity1614 .
