Differences in minor amputation rate in XXXX throughout Europe are in part explained by differences in disease severity at presentation.

@entity1 @entity3657 @entity6 @entity1066 @entity281 @entity204 @entity4760
OBJECTIVES: The incidence of minor amputation may vary significantly, and determinants of minor amputation have not been studied systematically. We evaluated minor amputation rate, the determinants of minor amputation and differences in amputation rate between European centres. METHODS: In the Eurodiale study, a prospective cohort study of 1232 @entity1 (1088 followed until end-point) with a new @entity4760 were followed on a monthly basis until healing, @entity204 , major amputation or up to a maximum of 1 year. Ulcers were treated according to international guidelines. Baseline characteristics independently associated with minor amputation were examined using multiple logistic regression modelling. Based on the results of the multivariable analysis, a disease severity score was calculated for each @entity1 . RESULTS: One hundred and ninety-four (18%) @entity1 underwent a minor amputation. Predictors of minor amputation were depth of the @entity1066 (odds ratio 6.08, confidence interval 4.10-9.03), @entity3657 (odds ratio 1.84, confidence interval 1.30-2.60), @entity281 (odds ratio 1.56, confidence interval 1.05-2.30) and male sex (odds ratio 1.42, confidence interval 0.99-2.04). Minor amputation rate varied between 2.4 and 34% in the centres. Minor amputation rate in centres correlated strongly with disease severity score at the moment of presentation to the foot clinic (r=0.75). CONCLUSIONS: Minor amputation is performed frequently in @entity6 foot centres throughout Europe and is determined by depth of the @entity3657 , @entity281 and male sex. There are important differences in amputation rate between the European centres, which can be explained in part by severity of disease at presentation. This may suggest that early referral to foot clinics can prevent minor amputations.
