Prevalence of Q-T interval dispersion in type 1 XXXX and its relation with cardiac ischemia : the EURODIAB IDDM Complications Study Group.

@entity1 @entity6 @entity16 @entity4148 @entity741 @entity989 @entity551 @entity413
OBJECTIVE: The interlead variation in duration of the Q-T interval on the surface electrocardiogram (Q-T interval dispersion [QTd]) has been shown to predict mortality in type 2 @entity6 @entity1 . We evaluated the prevalence of QTd prolongation in the EURODIAB population and its relation to corrected Q-T interval (QTc), sex, age, duration of @entity6 , blood @entity413 control, and complications. RESEARCH DESIGN AND METHODS; A total of 3,042 type 1 @entity6 @entity1 were studied. QTc was calculated according to the Bazett's formula; QTc > 0.44 s was considered abnormally prolonged. QTd was calculated using the difference between the maximum and the minimum QTc in any thoracic lead. QTd >0.080 s was considered abnormally prolonged. RESULTS: The prevalence of an increased QTd was 7%. A significant relation was observed between QTd prolongation and diastolic blood pressure (P < 0.05). A higher prevalence of QTd prolongation was observed in @entity1 with @entity741 (P = 0.004), whereas no relationship was observed with @entity989 , albumin excretion rate, or measures of somatic and @entity4148 . QTc and QTd were significantly related (P = 0.001); however, a proportion of @entity1 with normal QTd showed a prolonged QTc (>0.44 s). CONCLUSIONS: In @entity1 with type 1 @entity6 , QTd is associated with @entity551 but not @entity16 . Although QTd is statistically related to duration of QTc, increased QTd and increased QTc identify different @entity1 , and their predictive value deserves prospective evaluation.
