Leukocyte telomere shortening in grown-up @entity1 with XXXX .

@entity1 @entity5 @entity20322 @entity20319 @entity179 @entity20823 @entity299 @entity32271 @entity65
BACKGROUND/OBJECTIVES: @entity1 with @entity299 are exposed by repeated imaging to ionizing radiation, which may have important implications for lifetime health risks. Leukocyte telomere length (LTL), a reliable biomarker of genomic instability, is associated with increased risk of @entity5 and @entity65 . We investigated LTL in grown-up @entity1 with CHD (GUCHs) and a positive history of medical radiation exposure as well as the influence of functional polymorphisms of genes involved in DNA repair. METHODS: A group of 50 GUCH @entity1 (26 males; age 25.2  9.0years) and 50 healthy age/gender-matched subjects (20 males; 27.0  3.1years) were enrolled. In GUCH @entity1 , the cumulative exposure was estimated as effective dose (ED) in milliSievert. LTL was measured by quantitative RT-PCR. @entity20319 ( @entity20319 ) and @entity20823 ( @entity20823 ) SNPs (XRCC1 @entity20322 , XRCC1Arg194Tr and @entity20823 @entity32271 ) were evaluated. RESULTS: GUCHs showed significantly shorter LTL compared with controls (1.0  0.3 vs 1.3  0.4, p=0.001). A significant inverse correlation between LTL and cumulative radiological ED was observed (r=-0.34, p=0.03). @entity1 with Thr/Met @entity20823 or Met/Met @entity20823 genotypes were significantly associated with a significantly shorter LTL compared with wild-type genotype (p=0.01 for Thr/Met and p=0.008 for Met/Met). Carriers of @entity20319 194Trp and @entity20823 241Met alleles presented a significant interaction with cumulative radiation dose exposure for LTL (both pinteraction=0.02). CONCLUSIONS: GUCH @entity1 have LTL shortening, suggesting evidence of early biological aging. Common SNPs in DNA repair genes modify the effects of medical exposure to radiation LTL-related @entity179 .
