[Fibrotic remodeling of nasal mucosa in XXXX model after radiation injury].

@entity82 @entity1711 @entity1710 @entity35 @entity130
OBJECTIVE: To investigate the role of nasal mucosa @entity82 on radiation induced @entity130 . METHODS: Seventy two male @entity35 were randomly divided into two groups, control group and irradiation injured group (radiation dose were 40 Gy); the @entity35 were killed 1 week, 2 weeks, 4 weeks, 8 weeks, 3 months and 6 months after the finish of radiation. The middle turbinates of the animals were removed. The pathological change of the nasal mucosa were observed with scanning electron microscope, transmission electron microscope, @entity1710 and @entity1711 (HE), alcian blue-periodic acid-Schif (AB-PAS), and Masson Trichrome (MT). The Hyp content in nasal mucosa was measured with chemo-chromatometry. RESULTS: After radiation, the pathological characteristics in early stage (within 4 weeks) was acute inflammatory reaction. The repair of nasal mucosa started 4 weeks after radiation, lasted to 6 months. The deposition of collagen in nasal mucosa could be found 1 week after irradiation and increased gradually. CONCLUSION: Irradiation could induce a serials of pathological changes on nasal mucosa. The nasal mucosa @entity82 may be one of the reasons of persistent irradiation induced @entity130 .
