Evaluation of an extension set for intermittent intravenous drug delivery to XXXX .

@entity1 @entity801 @entity114 @entity972 @entity505 @entity2827 @entity413 @entity597
An intravenous administration set designed for delivery of drug doses to pediatric @entity1 was tested in vitro for the effect of fluid density and flow rate on drug delivery, and delivery of drug by this extension set was compared in vivo with delivery by other methods. @entity801 (as the @entity597 salt) and @entity114 G @entity972 were used to represent low-density and high-density drugs, respectively; a 1-mL solution of each drug, labeled with @entity505 14, was tested with each of two primary infusion solutions: 0.45% @entity2827 injection and 10% @entity413 injection. The drug dose was injected via a port into a piston-containing chamber from which an equivalent amount of the primary fluid was displaced. Serial samples collected from the end of the filter-containing extension set were analyzed for drug concentration using a liquid scintillation technique. In 12 @entity1 receiving i.v. @entity801 , this delivery method was compared in a randomized crossover trial with delivery by a syringe pump and by i.v. push. Each delivery system was used on one of three consecutive days, and serum @entity801 concentrations were measured by enzyme-multiplied immunoassay. The time required for in vitro delivery of the dose was dependent on flow rate. Density of the drug solution or the primary i.v. fluid did not significantly affect drug delivery. Serum @entity801 concentrations were not significantly different for the three delivery methods, but variability of drug delivery was greatest with the pediatric extension set. This pediatric extension set provides accurate and reliable drug delivery at primary infusion flow rates slower than 10 mL/hr when the drug dosage volume is 2-3 mL or less.
