Purified @entity1 and recombinant XXXX @entity634 induced accumulation of inflammatory peritoneal neutrophils and mononuclear phagocytes: possible contributions to antibacterial resistance.

@entity1 @entity558 @entity19 @entity634 @entity5125 @entity2604 @entity8885 @entity3352
Interleukin-1 (IL-1) mediates a number of proinflammatory biological responses that are thought to contribute to antibacterial resistance. In the present study we examined the ability of IL-1 to recruit inflammatory neutrophils and mononuclear phagocytes in vivo; a function that has been reported to be closely related to antibacterial resistance. Intraperitoneal injection of small amounts (1-10 LAF units) of purified @entity1 or recombinant @entity19 @entity634 (rIL-alpha) resulted in an increased influx of inflammatory neutrophils into the peritoneal cavity that peaked at 4-14 h after IL-1 injection. A small but consistent increase in peritoneal macrophages also was observed at 72 h after @entity8885 injection. The ability of @entity8885 to induce neutrophil accumulation was uninfluenced by polymyxin B, was sensitive to heat treatment (100 degrees C for 1 h), and was observed after i.p. injection into @entity558 -nonresponsive C3H/HeJ @entity19 . These three lines of evidence suggested that contaminating @entity558 did not contribute substantially to @entity8885 induced accumulation of neutrophils. Treatment of @entity19 with @entity3352 or @entity2604 did not abrogate @entity8885 induced neutrophil accumulation. @entity19 injected i.p. with increasing amounts of @entity8885 demonstrated a corresponding enhancement of their resistance to an i.p. @entity5125 challenge 4 h later, thus suggesting that IL-1 mediated inflammatory phagocyte accumulation may contribute in part to nonspecific antibacterial resistance.
