Perinatal and obstetric outcomes of dichorionic vs trichorionic XXXX .

@entity1 @entity6677 @entity2099 @entity14244 @entity5617
BACKGROUND: Clinical management and outcome of @entity6677 can be affected by chorionicity. In @entity2099 , @entity5617 has been associated with dichorionic (DC) and monochorionic placentation. Studies evaluating triplet pregnancy outcomes in relation to chorionicity have been few and may not reflect contemporary antenatal and neonatal care. OBJECTIVE: The objective of this study was to compare obstetric and perinatal outcomes in DC and trichorionic (TC) @entity2099 . STUDY DESIGN: We performed a retrospective cohort study of @entity2099 that delivered at >= 20 weeks' gestation at 2 Chicago area hospitals from January 1999 through December 2010. Chorionicity was determined by pathology specimen. Maternal and @entity1 charts were reviewed for obstetric and perinatal outcomes. RESULTS: The study population included 159 pregnancies (477 neonates) of which 108 were TC (67.9%) and 51 were DC (32.1%). Over 94% of mothers in this study had all 3 @entity1 survive to discharge regardless of chorionicity. No difference was found in perinatal mortality rate between DC and TC triplets (3.3% vs 4.6%; P  = .3). DC triplets were significantly more likely to be very low birthweight (41.8% vs 22.2%; odds ratio, 2.2; 95% confidence interval, 1.2-4.2; P  = .02) and to deliver at <30 weeks (25.5% vs 8.3%; odds ratio, 6.1; 95% confidence interval, 1.9-19.4; P  =  .002) compared to TC triplets. Criteria for @entity14244 ( @entity14244 ) were present in 3 DC @entity2099 (5.9%). Neonates in pregnancies complicated by @entity14244 were less likely to survive 28  days as compared to neonates from DC pregnancies that were not affected by @entity14244 (P  = .02) or TC neonates (P  = .02) Neonatal survival was similar in DC pregnancies not affected by @entity14244 and TC pregnancies (98.6% and 96.6%; P  = .7). CONCLUSION: Although perinatal mortality did not correlate with chorionicity, DC pregnancies were more likely to deliver <30 weeks' gestational age and have very low birthweight neonates. Neonatal mortality appears to be mediated by the presence or absence of @entity14244 as 28-day survival was worse in DC pregnancies complicated by @entity14244 , but similar between DC pregnancies not affected by @entity14244 and TC pregnancies.
