Outcome of fetuses with cerebral XXXX and septum pellucidum leaflet abnormalities.

@entity1 @entity851 @entity1276 @entity149 @entity1757
OBJECTIVE: The objective of this study was to assess the outcomes of the prenatal diagnosis of @entity1757 in fetuses referred for prenatal imaging with a finding of @entity1276 . MATERIALS AND METHODS: This study is a retrospective review of fetuses with a diagnostic code of @entity1757 from a larger prospective study. Four hundred twenty-five pregnant @entity1 with 433 fetuses referred for @entity1276 were imaged with ultrasound and MRI between July 1, 2003, and May 15, 2009. Four to six radiologists independently reviewed sonographic and MR images and recorded lateral ventricular diameters at the atrium and frontal horns, ventricular configuration, and the presence of @entity149 . Final prenatal ultrasound, MRI, and overall diagnoses were decided by consensus. Fetuses with a diagnostic code of @entity1757 were identified, and birth outcome, autopsy findings, postnatal imaging, and postnatal follow-up examinations were obtained. The analysis of covariance, controlling for gestational age, was used to compare ventricular dimensions between fetuses with @entity1757 and fetuses with isolated @entity1276 . Interrater agreement for the detection of @entity1757 was assessed with kappa statistics. Interrater agreement and intrarater agreement for frontal horn measurements were assessed by variance components analysis. RESULTS: Twenty-three fetuses had @entity1757 and 229 had isolated @entity1276 . Atrial and frontal horn diameters, adjusted for gestational age, were 77% and 98% larger, respectively, in fetuses with @entity1757 than in fetuses with isolated @entity1276 (p < 0.0001). Before the consensus conference, agreement among ultrasound readers was moderate (k = 0.54) and among MR readers, good (k = 0.69). Additional CNS findings were seen on MRI in 12 of 23 fetuses (52%). Eleven pregnancies with @entity1757 underwent termination and 12 progressed to livebirth; of the 12 livebirths, three neonates died. Neurodevelopmental follow-up was abnormal in all surviving @entity1 . CONCLUSION: A septal leaflet abnormality in the setting of @entity1276 is most frequently associated with other @entity149 and is associated with @entity851 .
