@entity4090 dynamics and @entity5 size in the prediction of surgical outcome for XXXX .

@entity1 @entity2013 @entity5 @entity4090 @entity1218 @entity1769 @entity21696 @entity4999
Each of 62 females were studied for a period of between two and 72 months (mean 36 months) following the removal of a @entity2013 by transsphenoidal pituitary surgery. Our aims were to define the relationships between pre- and post-operative features, the operative findings and the functional outcome. Pre-operative serum @entity4090 (PRL) concentrations correlated with @entity5 diameter (r = 0.55, p less than 0.001). Following surgery two groups of @entity1 were identified: Group 1, 46 spontaneously and regularly menstruating @entity1 and Group 2, 16 @entity1 with persistent @entity4999 . The @entity1 in Group 1 had significantly lower pre-operative and post-operative serum (PRL) concentrations (p less than 0.02 and p less than 0.001 respectively) and significantly greater PRL responses to thyrotrophin releasing hormone ( @entity1218 ) and @entity1769 stimulation after surgery (p less than 0.001). There was not a significant difference in @entity5 size between the groups. Forty-four (96 per cent) of the @entity1 in Group 1 had normal post-operative serum PRL concentrations within one week of surgery. By comparison (p less than 0.001) only 42 and 20 per cent respectively of Group 1 @entity1 who were tested had normal @entity1218 and @entity1769 evoked PRL secretion following surgery. Return of regular menstruation was associated with cessation of @entity21696 in 44 @entity1 (96 per cent) and ovulation occurred in 37 of 38 menstruating @entity1 for whom data are available. All @entity1 with normal @entity1218 and @entity1769 stimulation tests menstruated spontaneously. Nevertheless most @entity1 who menstruated did so in spite of retaining suppressed PRL responses. Of 46 @entity1 followed to date whose serum PRL was normal one week after surgery, seven later were found to have an elevation of serum PRL outside the normal range but in only two has this been persistent. We suggest that a single measurement of serum PRL one week following transsphenoidal pituitary surgery for @entity2013 provides a good basis for deciding about the future management of @entity1 who desire menstruation and pregnancy.
