Onset time and haemodynamic response after thiopental vs. XXXX in the elderly: a randomized trial.

@entity1 @entity680 @entity1875
BACKGROUND: The induction dose of hypnotic agents should be reduced in the elderly, but it is not well studied whether thiopental or @entity1875 should be preferred in this group of @entity1 . The aim of this study was to compare onset time, hypnosis level and the haemodynamic response after thiopental vs. @entity1875 for induction of anaesthesia. Our primary hypothesis was that in the elderly, thiopental had a shorter onset time than @entity1875 , defined as time to bispectral index (BIS) <50. METHODS: In this randomized and double-blinded study, we included 78 @entity1 . @entity1 were eligible, if they were scheduled for elective surgery with general anaesthesia and aged 60 or older. @entity1 received @entity680 10  g/kg and either thiopental 2.5 mg/kg or @entity1875 1.0 mg/kg, and depth of anaesthesia was determined with BIS the following 120 s along with clinical assessment of anaesthetic depth. The primary endpoint was the time from start of injection of the hypnotic to a BIS value below 50. RESULTS: Time to BIS <50 was significantly shorter in @entity1 receiving thiopental, where onset time was 52 s (median value) compared with 65 s in the @entity1875 group (P=0.01). Mean arterial pressure decreased 25.6 mmHg in the @entity1875 group and 15.6 mmHg in the thiopental group (P=0.003) within 120 s. Heart rate decreased 9.1 b.p.m. within 120 s in the @entity1 receiving @entity1875 compared with a decrease of 5.1 b.p.m. in @entity1 receiving thiopental (P=0.04). CONCLUSION: Thiopental was found to have a faster onset than @entity1875 in elderly surgical @entity1 .
