Histopathological Examination may be Useful for Assessment of XXXX and Lipomatosis of Pancreas Allograft Prior to Solid Organ Transplantation.

@entity8 @entity82 @entity788 @entity6574 @entity406 @entity982
BACKGROUND The results of @entity8 in a large degree on appropriate @entity788 allograft donor selection. Several risk factors of early surgical complications or @entity788 allograft loss following transplantation have been identified, but the final decision on @entity788 harvesting for transplantation belongs to the surgeon. In the present study we aimed to assess whether histopathological examination may be utilized for detection of @entity82 and @entity6574 in tissue from a potential @entity788 allograft. Additionally, we aimed to test whether presence of pancreatic @entity82 and @entity6574 may be explained solely by donor age and/or body mass index (BMI). MATERIAL AND METHODS Pancreata retrieved from 50 deceased organ donors referred to our institution and not transplanted between 2010 and 2013 were used for the present study. Tissue samples were excised from pancreata, fixed in @entity406 , and embedded in @entity982 . Presence and intensity of pancreatic @entity82 and @entity6574 were assessed semi-quantitatively. RESULTS @entity82 was found in the majority of study samples (72%), but it was usually mild or moderate. @entity6574 was present in 34% of the study cases. Presence of @entity82 was more frequent in older donors, but was still not rare in donors under 40 years old. Presence of @entity6574 did not seem to be significantly related to donor age. Neither pancreatic @entity82 nor @entity6574 was related to donor BMI. CONCLUSIONS There is no clear relationship between histological parenchymal changes in potential @entity788 allograft and donor age and BMI. Histopathological assessment of pancreatic @entity82 and/or @entity6574 can potentially facilitate decision making on @entity788 allograft acceptance for solid organ transplantation.
