Mild XXXX induces @entity8 in normal @entity35 .

@entity9503 @entity8 @entity101 @entity32886 @entity3449 @entity8433 @entity5052 @entity35 @entity208 @entity414
Mildly @entity9503 @entity35 develop @entity3449 -dependent @entity101 and @entity8 . @entity5052 might also induce changes in glomerular hemodynamics. Micropuncture experiments under deep anesthesia were performed in @entity35 fed a low-salt diet ( @entity8433 group), fed a low-salt diet and treated with @entity32886 (OA/ @entity8433 group), and fed a low-salt diet and treated with @entity32886 + @entity208 (OA/ @entity8433 /AP group) for 5 wk. The OA/ @entity8433 group developed @entity5052 and @entity101 compared with the @entity8433 group: 3.1 +/- 0.2 vs. 1.1 +/- 0.2 mg/dl (P < 0.01) and 143 +/- 4 vs. 126 +/- 2 mmHg (P < 0.01). @entity9503 @entity35 developed increased glomerular capillary pressure compared with the @entity8433 @entity35 : 56.7 +/- 1.2 vs. 51.9 +/- 1.4 mmHg (P < 0.05). Pre- and postglomerular resistances were not increased. Histology showed afferent arteriolar thickening with increased alpha-smooth muscle actin staining of the media. @entity208 prevented @entity5052 (1.14 +/- 0.2 mg/dl), systemic (121.8 +/- 2.8 mmHg) and @entity8 (50.1 +/- 0.8 mmHg), and arteriolopathy in @entity32886 -treated @entity35 . Linear regression analysis showed that glomerular capillary pressure and arteriolar thickening correlated positively with serum @entity414 and systolic blood pressure. Glomerular @entity101 may be partially mediated by an abnormal vascular response to systemic @entity101 due to arteriolopathy of the afferent arteriole.
