Cyclooxygenase-2 - An Imperative Prognostic Biomarker in XXXX - An Immunohistochemical Study.

@entity1 @entity5 @entity957 @entity3 @entity2247 @entity213
UNASSIGNED: @entity957 ( @entity957 ) is the most common @entity213 ( @entity213 ) with @entity3 and @entity5 recurrence resulting in 90  % of @entity5 associated mortality. @entity2247 , an inflammatory biomarker, has been shown to play a significant role in tumorigenesis of @entity957 . To study the expression of @entity2247 in @entity957 by immunohistochemistry and investigate its association with the clinicopathological parameters including @entity1 survival. A cross sectional study was carried out in 75 histologically confirmed cases of @entity957 . @entity2247 expression was evaluated by indirect streptavidin biotin method. The expression was semi-quantitatively assessed using established criteria. The expression profile of @entity2247 was correlated with the clinicopathological details like @entity5 size, regional lymphnode @entity3 , distant @entity3 , clinical stage, local recurrence of @entity5 , histological grade, and survival of @entity1 . Chi square and Kaplan Meier statistical tests were applied for assessing this association. @entity2247 expression was absent in normal oral mucosa. Over expression of @entity2247 was seen in 58 out of 75 specimens of @entity957 . Overexpression of @entity2247 was significantly associated with the lymphnode involvement, histological grade, local recurrence of @entity5 and @entity1 survival. @entity2247 expression represents an important biomarker of prognostic significance that may be used to identify a subset of @entity1 at high risk and to predict @entity1 survival.
