Combined topical XXXX and corticosteroid treatment for experimental @entity5132 keratomycosis.

@entity1 @entity2380 @entity2295 @entity95 @entity5132 @entity281 @entity364 @entity2687 @entity2024 @entity375 @entity617
PURPOSE: To determine the most efficient time point and concentration of topical corticosteroids in @entity5132 keratitis treated with @entity2380 . METHODS: Corneas of 105 @entity95 were infected with viable @entity375 cells of @entity5132 (2.5 x 10(5)). After a 48-hour incubation period, seven groups of animals were treated for 21 days with @entity2380 , with group I acting as a control, and groups II to VII receiving adjunct therapy with the corticosteroid @entity617 (5 or 10 times daily; 3, 9, or 15 days after @entity281 ). The degree of @entity2687 , ulceration, corneal clouding, hypopyon, @entity2024 , @entity2295 , and corneal perforation was monitored over a 24-day period, as well as recultivation and resistance to @entity2380 of the @entity5132 pathogen. RESULTS: The control group showed the highest level of corneal clouding and @entity2295 . In comparison, by day 24, the majority of groups also treated with @entity617 displayed significantly less corneal clouding and @entity2295 . An immediate decrease in corneal clouding was observed in groups treated with additional low- or high-dose @entity617 from day 9 after inoculation. After additional @entity617 treatment from day 9 or 15 after inoculation, no significant difference was detected in the recultivation rate of @entity5132 compared with the control. Early administration of @entity617 (day 3, low and high dose) resulted in the recultivation of significantly more @entity5132 . CONCLUSIONS: @entity2380 plus adjunct high-dose @entity617 treatment was most effective when administered 9 days after @entity281 . The delayed application of corticosteroids after treatment with antimycotic drugs in cases of @entity364 is therefore not contraindicated and may be beneficial in @entity1 .
