Effects of XXXX or @entity5217 on @entity943 and dispersion of refractoriness in chronically infarcted in anesthetized @entity235 .

@entity31802 @entity1162 @entity235 @entity944 @entity5217 @entity1188 @entity2224 @entity972 @entity583 @entity943 @entity855
The proarrhythmic effects of the @entity855 -sensitive @entity972 channel modulators @entity31802 (n = 10; 0.01 to 0.3 mg/kg i.v.), @entity5217 (n = 10; 0.3 to 10 mg/kg i.v.) or volume equivalents of vehicle (n = 10) were evaluated in post-infarcted anaesthetised @entity235 . @entity235 were anaesthetised, subjected to an anterior-apical @entity583 , and allowed to recover. At 7.4 +/- 0.7 days post @entity1188 , animals were anaesthetised again, electrophysiologic measurements (effective refractory periods, @entity1162 and @entity2224 thresholds) were taken, and animals were tested for @entity943 using a programmed electrical stimulation protocol. Only animals that did not have programmed electrical stimulation-inducible @entity943 were used. @entity2224 thresholds were determined twice, once before the first dose then after the last dose of drug. At the end of the experiment, animals were subjected to ligation of the left circumflex coronary artery and survival was measured over the next two hours. @entity31802 significantly increased heart rate and decreased blood pressure. Although @entity31802 significantly reduced effective refractory periods, it neither increased electrical dispersion, as determined by the standard deviation or coefficient of variance of the effective refractory period, nor did it enhance inducibility (0 out of 10 in both vehicle and @entity31802 treated animals), change @entity2224 thresholds, or reduce @entity944 survival relative to vehicle. @entity5217 did not increase electrical dispersion, but slightly increased the incidence of programmed electrical stimulation-induced @entity943 (3 out of 10), and lowered @entity2224 thresholds values. However, these changes were not statistically significant. @entity5217 did not significantly affect survival relative to vehicle.(ABSTRACT TRUNCATED AT 250 WORDS)
