The influence of a PHI-5-loaded XXXX membrane, on cutaneous wound healing in vivo.

@entity840 @entity219 @entity12310 @entity1346 @entity272
This study investigated whether a novel ionogenic substance, containing amongst others @entity219 and @entity12310 (PHI-5; Dermagenics Inc, Memphis, TN, USA), could improve the healing of full-thickness @entity272 . Uniform wounds were created on the right flank of @entity840 . Micro-grooved @entity1346 rubber membranes, containing 0 (controls), 1.25, 5.00, or 10.00 microg PHI-5, were sutured onto this wound. Standardized digital wound photographs were made after 1, 3, and 6 weeks. Also, wound biopsies were taken after 3 and 6 weeks for histological and histomorphometrical evaluation. For all study groups, 6 animals were used. Analysis of the 1-week digital photographs showed that the surface area of the wounds decreased significantly, with an increasing PHI-5 concentration. No other differences were found in the wound photographs. Also, no differences were measured in histomorphometry at 3 and 6 weeks. Concluding, in our study model a single application of PHI-5 did have a significant positive influence on initial wound healing.
