Value of XXXX vomit model in study of anti-emetic drugs.

@entity3973 @entity3974 @entity46270 @entity900 @entity391 @entity3826 @entity1769 @entity750
AIM: To establish a new, reliable vomit model of minks. METHODS: Adult male minks were randomly divided into 8 groups (n=6): @entity900 (7.5 mg/kg) intraperitoneal injection (i.p.) group, @entity3973 (40 mg/kg) intragastric injection (i.g.) group, @entity3826 (1.6 mg/kg) subcutaneous injection (s.c.) group, and 18 Gy whole-body X-irradiation group, @entity3974 injection group (2 mg/kg i.p.) 30 min later followed by @entity900 (7.5 mg/kg) i.p., normal saline (NS) i.p. injection control group, @entity1769 injection group (4 mg/kg i.p.) 30 min later followed by @entity3826 (1.6 mg/kg) s.c., NS i.g. control group. The frequency of @entity391 was calculated. After behavioral experiment, distribution of @entity750 in the ileum was detected by immunohistologic method. RESULTS: @entity900 , @entity3826 , @entity3973 and X-irradiation administered to minks evoked a profound emetic response in the animals. However, @entity391 were significantly inhibited by pretreatment with @entity3974 and @entity1769 in @entity900 and @entity3973 groups (P=0.018). Immunohistologic result showed that @entity750 released from enterochromaffin cells (EC cells) was involved in @entity391 mechanism. CONCLUSION: @entity46270 vomit model has a great value in studying the @entity391 mechanism and screening new antiemetic drugs.
