[Global DNA methylation and @entity1255 levels are lower in type 1 diabetes XXXX ].

@entity1 @entity1501 @entity1255 @entity5784 @entity1723 @entity26457 @entity22994
BACKGROUND: The worldwide rise in the incidence of @entity1723 ( @entity1723 ), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the environment as an underlying factor of this disease. This process can occur throughout epigenetic modifications of gene expression such as DNA methylation, in which several nutrients participate as cofactors. AIM: To determine DNA methylation status in @entity1723 @entity1 and if it is related to plasma levels of @entity26457 and @entity1255 ( @entity5784 ). MATERIAL AND METHODS: We obtained blood samples from 25 @entity1723 @entity1 aged 13.7    5.9 years (11 males) and 25 healthy subjects aged 31.1    7.8 years (16 males). DNA methylation was measured using a colorimetric kit in extracted DNA. Results are expressed as median (interquartile range). RESULTS: Compared with healthy controls, @entity1723 @entity1 had lower global DNA methylation (0.85 (0.91) % and 1.25 (1.16) % respectively, p < 0.02) and @entity5784 levels (4.8 (1.1)   mol/L and 7.3 (1.4)   mol/L respectively p < 0.01). There were no differences in @entity1501 levels between groups. A significant association between folates and global DNA methylation status was observed in @entity1723 @entity1 (r = -0.564, p < 0.01) and healthy subjects (r = 0.440, p = 0.03). CONCLUSIONS: @entity22994 @entity1 had lower levels of @entity5784 and global DNA methylation. It is relevant to further investigate if this imbalance also induces epigenetic changes in a gene-specific manner, especially in key genes involved in @entity1723 pathogenesis.
