XXXX : keys to early diagnosis.

@entity1 @entity1033 @entity12949 @entity6220 @entity12881 @entity281 @entity8492 @entity272
OBJECTIVE: To highlight the clinical features of @entity12949 that might facilitate earlier diagnosis. METHODOLOGY: Fifteen year retrospective review of proven neonatal HSV cases from a regional neonatal referral unit. RESULTS: Fifteen cases reviewed: 10 with central nervous system (CNS) disease, three with @entity8492 ( @entity8492 ) disease and two with disseminated disease (DIS). A median 4 day delay occurred between symptom onset and hospital admission. All cases presented after maternity hospital discharge, most commonly with feeding problems and lethargy. Six @entity1 presented with @entity272 ; parental @entity12881 was reported in three (20%) cases. Seven @entity1 died, four without @entity1033 treatment and three of 11 treated cases. Three of five @entity6220 survivors and all @entity1 with @entity8492 disease were normal at follow up. CONCLUSIONS: @entity1033 improves outcome in neonatal @entity281 . To improve outcome further earlier recognition of the non-specific presenting features of the disease is required.
