Neural and environmental influences on XXXX and conditioning of NK activity.

@entity19 @entity5 @entity1582 @entity9679 @entity421
The effects of physical restraint and poly I:C treatment on the growth of MOPC 104E @entity1582 and @entity19 @entity421 and survival of animals bearing such @entity5 were investigated. Our studies show that in the Balb/c @entity19 with MOPC 104E @entity1582 the effects of restraint stress were detrimental and lead to early death of the @entity19 . When the restraint was combined with poly I:C, during the early course of the disease, restraint stress neutralized the beneficial effects of the poly I:C treatment. These studies show that under certain circumstances, restraint stress can negate the effects of therapy. On the other hand, restraint stress produced an opposite effect in C3H/He @entity19 with @entity19 @entity421 treated in the same fashion. In @entity19 with @entity421 , restraint stress delayed @entity5 growth and increased the median survival time. When restraint stress was combined with poly I:C treatment, the mean @entity5 size was smaller and median survival was substantially increased over the control group. Because poly I:C therapy delayed @entity5 growth and increased survival in both models, efforts to strengthen this response were tested by conditioning. Our studies show the response to poly I:C as measured by elevation of the NK activity could be conditioned with @entity9679 smell. Conditioning of the host to raise immune activity to alter the outcome of disease is a new area yet to be explored and has important clinical significance. These studies, we believe, are important because they explore the connection between mind and body and resistance to disease.
