Effect of standardized perioperative XXXX interruption on the residual anticoagulation effect at the time of surgery or procedure.

@entity1 @entity556 @entity548 @entity63 @entity3926 @entity1031
UNASSIGNED: Essentials Anticoagulants need to be stopped preprocedure so there is little or no remaining anticoagulant effect. We assessed the residual anticoagulant effect with standardized interruption for @entity1 on @entity3926 . With this protocol, 80-86% of @entity1 had no residual anticoagulant effect at the time of a procedure. A standardized perioperative @entity3926 protocol appears to be safe, but requires further study. SUMMARY: Background In @entity1 taking @entity3926 who require treatment interruption for a surgery/procedure, a sufficient interruption interval is needed so that there is little or no residual anticoagulant effect at the time of the surgery/procedure. Methods A prospective cohort study of @entity1 receiving @entity3926 (110 mg or 150 mg twice daily) who required an elective surgery/procedure and received a standardized @entity3926 interruption protocol based on surgery/procedure @entity548 risk and renal function was performed. Before the surgery/procedure, a blood sample was taken for measurement of the prothrombin time (PT), activated partial thromboplastin time (APTT), @entity556 time (TT), and dilute @entity556 time (dTT). We determined the proportion of all @entity1 and those having a high @entity548 risk surgery/procedure with normal coagulation test results at the time of the surgery/procedure. The APTT and dTT were considered to be most likely to reflect a @entity3926 anticoagulant effect. @entity1 were followed up for 30 days postprocedure to assess for @entity548 and @entity1031 . Results One hundred and eighty-one @entity1 were studied: 118 with low @entity548 risk, and 63 with high @entity548 risk. For all @entity1 , the proportions with normal PT, APTT, TT dTT levels were 92.8%, 79.6%, 33.1%, and 80.7%, respectively. In @entity1 with high @entity548 risk, the proportions with normal PT, APTT, TT dTT levels were 93.7%, 85.7%, 57.1%, and 87.3%, respectively. During follow-up, there was one (0.6%) @entity548 , there were nine (5.0%) minor @entity548 , and there was one (0.6%) transient @entity63 attack. Conclusions In @entity1 receiving @entity3926 who require an elective surgery/procedure, a standardized interruption protocol yielded 80-86% of @entity1 with no residual anticoagulant effect at the time of surgery/procedure, and with a low incidence of @entity548 .
