XXXX after traumatic white matter injury: correlation with acute neuroimaging and outcome.

@entity1 @entity131 @entity66 @entity194 @entity21 @entity62
@entity131 ( @entity131 ) is a pathologically heterogeneous disease, including injury to both neuronal cell bodies and axonal processes. Global @entity62 is common after @entity131 . This study was designed to determine the relationship between neuroimaging markers of acute @entity21 ( @entity21 ) and @entity194 months later. We performed high-resolution magnetic resonance imaging (MRI) at 3 Tesla (T) in 20 @entity1 who suffered non-penetrating @entity131 , during the acute (within 1 month after the injury) and chronic stage (at least 6 months after the injury). Volume of abnormal fluid-attenuated inversion-recovery (FLAIR) signal seen in white matter in both acute and follow-up scans was quantified. White and gray matter volumes were also quantified. Functional outcome was measured using the Functional Status Examination (FSE) at the time of the chronic scan. Change in brain volumes, including whole brain volume (WBV), white matter volume (WMV), and gray matter volume (GMV), correlates significantly with acute @entity21 volume (r = -0.69, -0.59, -0.58, respectively; p <0.01 for all). Volume of acute FLAIR hyperintensities correlates with volume of decreased FLAIR signal in the follow-up scans (r = -0.86, p < 0.001). FSE performance correlates with acute hyperintensity volume and chronic @entity194 (r = 0.53, p = 0.02; r = -0.45, p = 0.03, respectively). Acute @entity66 measured by FLAIR imaging are strongly predictive of post-traumatic @entity194 . Our findings suggest that axonal pathology measured as @entity62 following @entity131 can be identified using MRI, and may be a useful measure for @entity21 -directed therapies.
