Long-term outcomes of survivors of ICU XXXX requiring renal replacement therapy: a 10-year prospective cohort study.

@entity1 @entity8 @entity101 @entity3124 @entity810 @entity299 @entity204 @entity454
BACKGROUND: @entity810 ( @entity810 ) requiring renal replacement therapy (RRT) is associated with high in-hospital morbidity and mortality in @entity3124 @entity1 . Long-term outcomes have received little attention. METHODS: The aim of this study was to characterize @entity8 ( @entity8 ) nexus in @entity3124 @entity1 with @entity810 (RIFLE class F). We performed a single-centre prospective observational study of 425 consecutive @entity3124 @entity1 with @entity810 requiring RRT. None of these @entity1 had pre-existing @entity8 . Primary outcomes were vital status and renal function at hospital discharge and at 5 and 10 years of follow-up. RESULTS: The overall in-hospital mortality of the study cohort was 47%, the mortality rates at 1, 5 and 10 years were 65, 75 and 80%, respectively. At hospital discharge, recovery of renal function was complete in 56% of survivors. None of these @entity1 developed @entity8 during follow-up. Ninety percent of the 100 survivors with partial recovery of renal function had ongoing @entity8 during long-term follow-up. @entity8 progressed to @entity454 ( @entity454 ) in 12 @entity1 (3% of the cohort or 5% of survivors). The @entity1 with post-AKICKD had a higher prevalence of @entity101 , a higher rate of fatal @entity299 and a higher all-cause @entity204 rate. CONCLUSION: Long-term survival of @entity3124 @entity1 with @entity810 requiring RRT is poor and determined by the development of de novo @entity8 . There is a need for close follow-up of @entity1 surviving @entity810 to prevent progressive @entity8 and to reduce associated lethal @entity299 .
