The effects of @entity31896 on cautery disbudding pain and stress responses in preweaned dairy XXXX .

@entity1421 @entity701 @entity31896 @entity39120 @entity291 @entity616
UNASSIGNED: Perioperative analgesic effects of oral @entity31896 following cautery disbudding were investigated in preweaned @entity291 . Twenty Holstein @entity291 approximately 4 to 6 wk old received a single oral dose of @entity31896 , a nonsteroidal antiinflammatory, at 0.5 mg/kg (n = 10) or placebo (n = 10) in a randomized controlled clinical trial. Responses, including ocular temperature determined by infrared thermography, pressure algometry measuring mechanical nociception threshold, and heart rate, were evaluated at 2, 4, 7, 8, and 24 h after @entity616 and cautery disbudding. Blood samples were collected over 96 h and analyzed for plasma @entity701 and @entity39120 concentrations by RIA. Additionally, ex vivo @entity1421 concentrations were determined over a 72-h study period using an enzyme immunoassay. Data were analyzed using a linear mixed effects model with repeated measures. An inhibition of ex vivo @entity1421 synthesis was observed from 12 to 48 h following disbudding in @entity291 treated with @entity31896 . Cautery disbudding was associated with an increased nociception for the duration of sampling (24 h). During the initial 24-h period following disbudding, no difference in response between treatment groups was noted. Following 24 h, mean @entity701 concentrations diverged between the 2 study groups with placebo-treated @entity291 having increased @entity701 concentrations at approximately 48 h after disbudding. Furthermore, the overall integrated @entity701 response as calculated as area under the effect curve tended to be reduced in @entity31896 -treated @entity291 . The prolonged effects of cautery dehorning require further investigation. Moreover, the effect of @entity31896 on @entity701 reduction observed in this study requires additional exploration.
