Inhibition of @entity4404 binding to XXXX and @entity556 generation in an unselected population with @entity49 .

@entity1 @entity556 @entity4404 @entity9500 @entity49 @entity1150 @entity854 @entity358 @entity1211 @entity6894
OBJECTIVE: To examine the effect on @entity4404 binding to @entity6894 (CL) and in vitro @entity556 generation by plasma samples from an unselected population of @entity1 with confirmed @entity49 and matched controls. The prevalence of autoimmune antiphospholipid antibodies (aPL) was also determined. METHODS: A total of 111 @entity1 who presented to a single emergency room with symptoms suggestive of @entity1211 ( @entity1211 ) disease were studied. In 34 @entity1 the diagnosis of lower limb @entity1150 ( @entity1150 ) and/or @entity358 ( @entity358 ) was confirmed ( @entity1211 + group). In the remaining 77 @entity1 the diagnostic workup was negative ( @entity1211 - group). Plasma samples were collected prior to the initiation of anticoagulation and examined for IgG anticardiolipin (aCL), IgG anti-beta2-glycoprotein I (GPI), and IgG anti-prothrombin (aPT antibodies) by ELISA. In addition, the effect of individual @entity1 and control plasma samples on @entity4404 binding to CL and on in vitro @entity556 generation was determined by a competitive ELISA and a chromogenic assay, respectively. RESULTS: The prevalence and levels of IgG aCL, anti- @entity9500 , and aPT antibodies were similar in the @entity1211 + and @entity1211 - groups. However, plasma samples from the @entity1211 + group caused a significant inhibition of in vitro @entity556 generation (mean +/- SD Z score: -0.66 +/- 0.97 vs 0.26 +/- 1.46; p < 0.001) and a concurrent but less impressive inhibition of @entity4404 binding to CL (mean +/- SD Z score: -2.53 +/- 1.44 vs -2.05 +/- 1.61; p = 0.123). Upon analyzing a panel of clinical and laboratory variables, only age and inhibition of @entity556 generation were significantly associated with @entity1211 . CONCLUSION: Our findings suggest that @entity854 in @entity4404 physiology may contribute to the procoagulant state in @entity1 with @entity49 .
