Vascular risk factors promote conversion from @entity73 to XXXX .

@entity455 @entity101 @entity6 @entity66 @entity303 @entity73 @entity1007 @entity195
OBJECTIVE: Growing evidence suggests that @entity455 ( @entity455 ) contribute to @entity73 . The aim of this study was to investigate the impact of @entity455 on the conversion from @entity73 ( @entity73 ) to @entity195 ( @entity195 ) @entity303 . METHODS: A total of 837 subjects with @entity73 were enrolled at baseline and followed up annually for 5 years. The incidence of @entity195 was investigated. A mixed random effects regression model was used to analyze the association between @entity455 and the progression of @entity73 assessed with Mini-Mental State Examination and instrumental Activities of Daily Living. Cox proportional hazard models were used to identify the association between @entity455 and @entity303 conversion, and to examine whether treatment of @entity455 can prevent @entity303 conversion. RESULTS: At the end of the follow-up, 298 subjects converted to @entity195 , while 352 remained @entity73 . Subjects with @entity455 had a faster progression in cognition and function relative to subjects without. @entity455 including @entity101 , @entity6 , @entity66 , and @entity1007 increased the risk of @entity303 conversion. Those subjects with @entity73 in whom all @entity455 were treated had a lower risk of @entity303 than those who had some @entity455 treated. Treatment of individual @entity455 including @entity101 , @entity6 , and @entity1007 was associated with the reduced risk of @entity195 conversion. CONCLUSION: @entity455 increased the risk of incident @entity195 . Treatment of @entity455 was associated with a reduced risk of incident @entity195 . Although our findings are observational, they suggest active intervention for @entity455 might reduce progression in @entity73 to @entity195 .
