Proteins in the urine associated with XXXX and other neuromuscular diseases.

@entity1 @entity1555 @entity3986 @entity121
1. Up to 200 protein staining spots could be detected on two-dimensional electrophoresis of urine from healthy @entity1 . Other minor spots were occasionally present. 2. Although the electropherograms exhibited constant characteristic features some variation in protein pattern was observed between individuals and with a given individual at different times. 3. Two additional proteins, spots C and D, were consistently present in urine from @entity1 with @entity1555 . Spot C was also present in the urine of about 60% of obligatory carriers of this @entity3986 . 4. The protein responsible for spot C had a molecular weight of 26000 and an isoelectric point of 5.3. 5. Spot C was also detected in the urine of @entity1 with other neuromuscular conditions. Neither spot C nor spot D could be detected in the urine of @entity1 with physical disabilities other than those of neuromuscular origin. 6. It is concluded that the urinary excretion of spot C, and probably of spot D, is a consequence of @entity121 and that their detection has potential as a diagnostic tool.
