The neural correlates and role of D1 XXXX receptors in renewal of extinguished @entity167 -seeking.

@entity10095 @entity1640 @entity935 @entity167 @entity5019 @entity35
We used an ABA renewal design to study the neural correlates, and role of D1 @entity935 receptors, in contextual control over extinguished @entity167 -seeking. @entity35 were trained to respond for 4% beer in one context (A), extinguished in a different (B) context, and then tested for responding in the original training context (A) or the extinction context (B). ABA renewal was mediated by D1 @entity935 receptors because it was prevented by @entity10095 . ABA renewal of @entity167 -seeking was associated with selective increases in @entity5019 protein induction in basolateral amygdala, ventral accumbens shell, and lateral hypothalamus (renewal-associated @entity5019 ). By contrast, being tested was associated with increased @entity5019 induction in anterior cingulate, prelimbic and infralimbic cortex, rostral agranular insula, dorsomedial accumbens shell, and accumbens core (test-associated @entity5019 ). Renewal-associated @entity5019 in ventral accumbens shell and lateral hypothalamus, but not basolateral amygdala, was D1 @entity935 receptor dependent. Double immunofluorescence showed that renewal-associated @entity5019 was expressed in orexin-negative @entity1640 neurons. However, @entity5019 induction in either @entity1640 orexin-negative or orexin-positive neurons was positively and significantly correlated with @entity167 -seeking. Test-associated @entity5019 induction was observed in orexin-positive perifornical neurons. In both regions, @entity5019 expression was dependent on D1 @entity935 receptors. These results suggest that renewal of extinguished @entity167 -seeking depends on a distributed neural circuit involving basolateral amygdala, ventral accumbens shell, and lateral hypothalamus that involves D1 @entity935 receptors. Comparison with our previous results [Hamlin AS, Blatchford KE, McNally GP (2006) Renewal of an extinguished instrumental response: Neural correlates and the role of D1 @entity935 receptors. Neuroscience 143:25-38] permits identification of similarities and differences in the correlates of renewal of extinguished drug- and natural-reward seeking.
