Adjuvant radiotherapy for XXXX : a dosimetric comparison of conformal radiotherapy and intensity-modulated radiotherapy.

@entity1 @entity137 @entity390 @entity5 @entity294 @entity1086 @entity204
AIM: To assess the efficacy and @entity137 of conformal radiotherapy (CRT) and compare with intensity-modulated radiotherapy (IMRT) in the treatment of @entity1086 . METHODS: Between November 2003 and January 2010, 20 @entity1 with @entity1086 were treated with CRT with or without chemotherapy after surgical resection. Preliminary survival data were collected and examined using both Kaplan-Meier and actuarial analysis. Demographic and treatment parameters were collected. All @entity1 were planned to receive 46-56 Gy in 1.8 or 2.0 Gy per fraction. CRT planning was compared with IMRT. RESULTS: The most common reported acute @entity137 requiring medication (Radiation Therapy Oncology Group, Radiation Therapy Oncology Group Grade 2) were @entity390 (10/20 @entity1 ) and @entity294 (3/20). There were no treatment-related @entity204 . Compared with CRT planning, IMRT significantly reduced the volume of right kidney receiving > 20 Gy and the volume of liver receiving > 30 Gy. IMRT has a negligible impact on the volume of left kidney receiving > 20 Gy. The 95% of prescribed dose for a @entity5 volume using either 3D CRT or IMRT planning were 84.0%    6.7%, 82.9%    6.1%, respectively (P > 0.05). CONCLUSION: IMRT achieves similar excellent target coverage as compared with CRT planning, while reducing the mean liver dose and volume above threshold dose. IMRT offers better sparing of the right kidney compared with CRT planning, with a significantly lower mean dose and volume above threshold dose.
