Primary XXXX : A retrospective study over 35 years from a single institution.

@entity1 @entity39236 @entity0 @entity5 @entity5426
AIM: The aim of this study was to contribute to the collected knowledge of prognostic factors in @entity0 ( @entity0 ) to the benefit of possible future prospective studies and therapeutic guidelines. METHOD: All @entity1 with pathologically verified @entity0 in the period of 1979-2014 were extracted from a hospital-based database at Aarhus University Hospital. All records were reviewed for @entity1 and @entity5 characteristics. Primary endpoints were overall survival, disease-free survival (DFS) and disease-specific survival (DSS). Adjustments were made for age, @entity5 location, surgical strategy, size, histological classification, prior radiation and grade. Prognostic factors were determined by the use of Cox proportional hazard ratio. RESULTS: In total 42 @entity1 were identified. Surgical resection was the main method of treatment. Nineteen (45%) @entity1 were initially selected for lumpectomy, of these 68% needed at least one re-excision to attain wide margins. In total 55% experienced recurrence, loco regional in 43%. Five-years overall survival was 49%, five-year DFS was 48% and five-year DSS was 40%. Significant prognostic factors were size and grade. A trend towards better survival in those with superficial @entity5 was observed as well as an increased incidence in @entity39236 ( @entity5426 ) of the breast, however, prognosis was no different from non-radiation-induced @entity5426 . CONCLUSION: Prognostic factors in @entity0 @entity1 were size and grade with a trend towards better survival in those with superficial @entity5 . There was no difference in survival between radiation-induced and spontaneous @entity0 . High rate of local recurrence suggests the need for aggressive surgical approach or the routine addition of postoperative radiotherapy in those selected for breast conserving surgery (BCS).
