[Effect of @entity617 treatment on the experimental inducement of primary amoebic XXXX ]

@entity19 @entity5422 @entity1711 @entity281 @entity1710 @entity617
Present study aimed to elucidate the immunosuppressive effect of @entity617 on @entity281 in @entity19 . N. fowleri was cultured in CGVS medium (Willert and Le Ray, 1973). White female @entity19 , weighing about 18 g, used for experiments were divided into five groups; untreated control group, @entity617 treated groups (before, during and after @entity281 ), and only @entity617 treated group. In the @entity617 treated group, the hormone was injected intramuscularly 5 doses of 10 mg/kg every other day. According to designated time of treatment, each @entity19 was challenged with 1 x 10(5) N. fowleri intranasally. Changes of body weights, clinical manifestations and number of dead @entity19 were observed. Brain and lung tissues of dead @entity19 were cultured in the non-nutrient agar (Kasprzak and Mazur, 1972), or stained with @entity1710 - @entity1711 for the examination of histopathological changes. Results of the experiment are summarized as follows: Mortality among the @entity617 treated groups was higher than that in untreated control group, and among the treated groups, the pretreated group showed shorter survival time. Body weights among untreated control @entity19 showed no significant increase, however, treated groups of @entity19 showed the decrease during the administration and recovery of the weights were observed at 2 to 3 days after the completion of treatment. In the treated control groups, the infected @entity19 began to show the pathologic findings 5 days after @entity281 while the untreated @entity19 began to show the findings 8 days after @entity281 . Tissue damages in brain and lung occurred due to virulence of amoeba were more severe among treated @entity19 than that in untreated control group. The above mentioned results suggest that the treatment with @entity617 weaken the resistance of @entity19 against @entity281 , and probably induce more severe primary amoebic @entity5422 . Especially severe pathological findings were shown in pre-treated group, compared with untreated group.
