Alterations of antioxidant biomarkers and type I collagen deposition in the parotid gland of XXXX -induced @entity6 @entity35 .

@entity3496 @entity3918 @entity6 @entity1865 @entity948 @entity3839 @entity969 @entity35 @entity11669 @entity4854 @entity413
BACKGROUND AND OBJECTIVE: @entity11669 is a competitive inhibitor of intestinal alpha-glycosidases that slows the breakdown of @entity969 and starch, thereby reducing @entity413 and @entity948 absorption. The aim of this study was to evaluate the effect of @entity11669 treatment on antioxidant parameters and deposition of type I collagen in the parotid glands of @entity6 @entity35 . METHODS: @entity6 was induced by intravenous injection of @entity3839 , and @entity35 were divided into four groups: non- @entity6 (NDM), @entity6 ( @entity3918 ), @entity6 treated with 25mg/kg @entity11669 ( @entity3496 ) and non- @entity6 treated with @entity11669 (NDMA). Changes in enzymatic antioxidant systems, such as the activity of SOD and GPx enzymes, were evaluated, and the specific staining pattern of the type I collagen fibres was investigated in the @entity35 parotid glands. RESULTS: The @entity3918 group presented high levels of SOD and GPx enzymes, which were reduced by @entity11669 treatment. Tissue damage, which was indicated by an increased @entity1865 concentration in the parotid glands of @entity35 in the @entity3918 group, was also reversed in the @entity3496 group. Moreover, type I collagen fibres from @entity3918 @entity35 were more intensely stained than those of NDM @entity35 . @entity11669 treatment was effective in decreasing collagen deposition, which was shown by a decrease in staining intensity of approximately 25%. CONCLUSIONS: These results suggest that the @entity6 state influences the type I collagen concentration in the parotid glands of @entity35 . In addition, @entity11669 treatment was helpful in preventing the deposition of such fibres, as well the increase in oxidative stress induced by @entity4854 .
