RETINAL MORPHOMETRY CHANGES MEASURED WITH SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY AFTER PAN-RETINAL PHOTOCOAGULATION IN XXXX WITH PROLIFERATIVE DIABETIC RETINOPATHY.

@entity1 @entity2175 @entity6 @entity2479 @entity989
PURPOSE: To identify the effects of pan-retinal laser treatment on the integrity of neurosensory retinal layers. METHODS: @entity1 were examined with fluorescence angiography after a standardized examination for @entity6 and a peripapillary ring scan with spectral domain optical coherence tomography. A single-session pan-retinal photocoagulation was performed using the PASCAL pattern scanning argon laser applying a minimum of 1,500 spots. Optical coherence tomography was evaluated more than 6 months. RESULTS: Eighteen eyes of 12 consecutive @entity1 with new onset, treatment-naive proliferative @entity6 secondary to @entity2175 were treated and retinal optical coherence tomography morphology evaluated. Retinal nerve fiber layer thickness increased statistically significantly from baseline to week 1, when it reached its peak. The combined thickness of the outer plexiform and the inner nuclear layers and the combined thickness of the inner plexiform and the ganglion cell layers showed no relevant changes. The combined thickness of the retinal pigment epithelium and the photoreceptor cell layers decreased at month 1 followed by a steady increase in thickness, which remained below baseline values over time. CONCLUSION: Pan-retinal photocoagulation in proliferative @entity6 leads to a slowly reversible, marked biological response with statistically significant morphometric changes detected by spectral domain optical coherence tomography. @entity989 and outer nuclear layers induce an increase in @entity2479 . Simultaneously, the photoreceptor and retinal pigment epithelium layers decrease in thickness. These changes indicate @entity989 after pan-retinal laser therapy.
