Preoperative Submucosal Injection of @entity505 Nanoparticles Improves Lymph Node Staging Accuracy in XXXX after Neoadjuvant Chemoradiotherapy.

@entity505 @entity1 @entity11363 @entity5
BACKGROUND: The aim of this study was to evaluate the association between the number of nodes harvested and the rate of node positivity, and to evaluate the effect of @entity505 nanoparticles (CNPs) in improving lymph node detection and staging accuracy in @entity1 who received neoadjuvant chemoradiotherapy (NCRT) followed by curative resection. STUDY DESIGN: Between September 2008 and June 2014, 152 consecutive @entity5 @entity1 treated with NCRT and curative resection were included. Forty-five @entity1 underwent preoperative submucosal injection of CNPs ( @entity11363 group); the other @entity1 underwent surgery only (control group). The relationship between the number of lymph nodes harvested and the rate of node positivity was investigated. A comparison of the number of harvested lymph nodes and the node positivity rate between the 2 groups was also performed. The lymph nodes in the @entity11363 group were analyzed in detail. RESULTS: The rate of node positivity increased gradually from 8.6% in @entity1 with 1 to 5 nodes assessed to 37.8% in @entity1 with 17 to 44 nodes assessed. The number of lymph nodes harvested was an independent risk factor for node positivity (p  = 0.036). The mean number of lymph nodes retrieved in the @entity11363 group was more than in the control group (21.1 vs 8.0, p  = 0.000). The percentage of @entity1 with positive lymph nodes was lower than in the control group (19.6% vs 35.6%, p  = 0.037). In the @entity11363 group, of 58 metastatic lymph nodes, 45 (77.6%) were dyed. Of 37 metastatic lymph nodes smaller than 5 mm, 33 (89.2%) were dyed. CONCLUSIONS: More precise oncologic prognosis assessment was provided for @entity1 with @entity5 after NCRT by increasing the number of lymph nodes counted using a dye-tracing method, indicating that the use of CNPs is beneficial.
