Identification of a putative pathway for the muscle homing of stem cells in a XXXX model.

@entity17776 @entity19 @entity3986 @entity22416 @entity1555 @entity37196 @entity121 @entity6232
Attempts to repair @entity121 in @entity1555 ( @entity1555 ) by transplanting skeletal myoblasts directly into muscles are faced with the problem of the limited migration of these cells in the muscles. The delivery of myogenic stem cells to the sites of @entity121 via the systemic circulation is a potential alternative approach to treat this disease. Muscle-derived stem cells (MDSCs) were obtained by a MACS(R) multisort method. Clones of MDSCs, which were @entity17776 +/ @entity22416 -/ @entity6232 +, were found to adhere firmly to the endothelium of mdx dystrophic muscles after i.v. or i.m. injections. The subpopulation of @entity17776 +/ @entity22416 - MDSCs expressing @entity6232 was called homing MDSCs (HMDSCs). Treatment of HMDSCs with antibodies against @entity6232 prevented adhesion to the muscle endothelium. Importantly, we found that vascular endothelium from striate muscle of young mdx @entity19 expresses mucosal addressin cell adhesion molecule-1 ( @entity37196 ), a ligand for @entity6232 . Our results showed for the first time that the expression of the adhesion molecule @entity6232 is important for muscle homing of MDSCs. This discovery will aid in the improvement of a potential therapy for @entity3986 based on the systemic delivery of MDSCs.
