The prognostic significance of in vitro bone marrow growth pattern in XXXX .

@entity1 @entity981 @entity894
The growth pattern of bone marrow cells in agar culture was studied in 56 @entity1 with untreated @entity981 . 4 different growth patterns were recognized: (A) colony and cluster formation, (B) growth of small clusters (3-20 cells) only but less than 600/10(5) cells, (C) growth of small clusters only but more than 600/10(5) cells, and (D) no growth in vitro. @entity1 in group A and B had a significantly higher remission rate (23/34) than @entity1 in group C and D (3/22). This was true also when only @entity1 below 60 years of age were considered. The median survival time of @entity1 in group A and B was 7.3 months and 9.4 months, and in group C and D 4.0 months and 3.3 months. Identical growth patterns were found for marrow and blood cells in 21 of 27 @entity1 studied and the number of clusters in blood and marrow showed a significant correlation (r = +0.96, P less than 0.001). The mean @entity894 ( @entity894 ) of myeloblasts determined in 32 @entity1 was 14.8 +/- 7.8% (SD). @entity1 with @entity894 below 15% tended to have a higher remission rate than @entity1 with @entity894 above 15%. It is concluded that the in vitro growth pattern at diagnosis of bone marrow cells from @entity1 with ANLL is of value in detecting @entity1 with a poor response to current therapeutic protocols. Such information could possibly lead to alternative cytostatic regimes in these @entity1 .
