Kinetics of dissolution of XXXX calculi with @entity460 -chelating irrigating solutions.

@entity1098 @entity460 @entity3835
Dissolution of @entity3835 urinary calculi was studied in vitro. Rate constants were calculated by measuring the concentration of @entity460 in solution during dissolution. Various irrigating agents, including @entity1098 ( @entity1098 ) and other @entity460 -chelating substances, were tested at different concentrations and pH values. @entity1098 was the most effective agent in dissolving @entity3835 calculi. When @entity1098 was used, the rate of dissolution depended on both concentration and pH. At a pH of 7.5 or 10.0, the rate of dissolution increased progressively with the @entity1098 concentration. At each concentration tested, dissolution was faster at a pH of 10.0 than at a pH of 7.5. Calculated rate constants were extrapolated to determine whether in vivo irrigation with @entity1098 solutions is clinically practical. Even at an @entity1098 concentration of 0.03 M at a pH of 7.5, a two mm. calculus could be dissolved within 48 hr. Although dissolution of @entity3835 calculi is not a practical first-line treatment, it might be a useful adjunct to percutaneous stone removal or extracorporeal shock wave lithotripsy.
