@entity3969 gene single nucleotide polymorphism @entity73166 predicts a favorable outcome in XXXX with @entity981 .

@entity1 @entity981 @entity5434 @entity73166 @entity3052 @entity8587 @entity3969
PURPOSE: @entity3969 gene single nucleotide polymorphism ( @entity8587 SNP) @entity73166 has been described as a favorable risk marker in @entity1 with @entity3052 . Subsequent studies revealed inconsistent results in both adult and pediatric @entity1 . We analyzed its impact on clinical outcome in @entity1 with @entity981 ( @entity981 ) for the first time. METHODS: @entity8587 SNP @entity73166 of 158 @entity1 with @entity981 treated according to @entity981  nster treatment trials from 1990 to 2009 and 43 hematopoietic stem cell donors was analyzed by allelic discrimination. @entity8587 SNP status was correlated with disease characteristics and clinical outcome comparing SNP ( @entity8587 (GG/AG)) and wildtype ( @entity8587 (AA)). RESULTS: At least one minor allele was found in 23.4  % of @entity1 and 34.9  % of donors (P  =  0.07). Distribution of @entity1 and disease  characteristics was similar between @entity8587 (GG/AG) and @entity8587 (AA). In multivariate analyses, @entity8587 SNP was an independent good prognostic marker for cumulative incidence of relapse ( @entity5434 @entity8587 (AA) vs. @entity8587 (GG/AG) HR  =  3.384, P  =  0.021) and event-free survival (EFS; event risk @entity8587 (AA) vs. @entity8587 (GG/AG) HR  =  2.503, P  =  0.036). Univariate subanalyses of @entity1 who underwent an allogeneic hematopoietic stem cell transplantation revealed more significant differences in @entity5434 (P  =  0.017), EFS (P  =  0.012), and overall survival (OS; P  =  0.017). Donor's @entity8587 SNP status did not affect outcome. We found no correlation between @entity8587 SNP and @entity8587 expression level at diagnosis (P  =  0.634). CONCLUSION: @entity8587 SNP @entity73166 predicts improved @entity5434 and EFS. Outcome differences were more prominent in transplanted @entity1 . Our findings identify @entity8587 SNP @entity73166 as a favorable risk marker in @entity981 which is independent from known risk factors.
