Radiation-induced @entity33 : a randomized clinical trial of micronized XXXX versus salt _ soda mouthwashes.

@entity1 @entity135 @entity137 @entity3136 @entity1697 @entity66 @entity1161 @entity5 @entity33 @entity5418 @entity158 @entity3137
@entity3136 is one of the major @entity137 caused by @entity1161 ( @entity1161 ) treatments to the head and neck. The clinical efficacy of @entity5418 (Carafate R) mouthwash for @entity135 @entity1 (HNC) is not consistent across studies. In this study, it was hypothesized that if the particles in the original @entity5418 suspension were micronized (i.e., < or = 25 microns) then the coating action of the mouthwash in the @entity1697 would be enhanced. The purpose of this pilot study was to compare the efficacy of micronized @entity5418 (Carafate R) mouthwash and salt _ soda mouthwash in terms of the severity of the @entity33 , the severity of @entity158 , and the time required to heal @entity1161 -induced @entity33 in @entity1 with HNC. Severe @entity33 and @entity158 can interfere with the ingestion of food and fluids, so @entity1 ' body weights were measured as well. All @entity1 in this randomized clinical trial carried out a systematic oral hygiene protocol called the PRO-SELF: Mouth Aware (PSMA) Program. @entity1 who developed @entity1161 -induced @entity33 anytime during their course of @entity1161 were randomized to one of the two mouthwashes and followed to the completion of @entity1161 and at one month following @entity1161 . Two referral sites were used for the study. Repeated measures occurred with the following instruments/variables: MacDibbs Mouth Assessment and weight. @entity66 , and @entity5 treatment information was also obtained. Thirty @entity1 successfully completed the study. The typical @entity1 was male (70%), married/partnered (70%), White (63%), not working or retired (73%), and had an average of 14.5 years of education (SD = 3.7). T-tests and Chi-square analyses with an alpha set at 0.05 were used to compare differences between the two mouthwashes. No significant differences were found in the number of days to onset of @entity33 (i.e., 16 +/- 8.4 days). When @entity1 had their worst MacDibbs score, (i.e., the most severe @entity33 ), there were no significant differences between the mouthwashes as to MacDibbs score, the @entity1161 dose received, or ratings of @entity158 (upon swallowing). Similarly, at the end of @entity1161 , no significant differences were found between mouthwashes as to MacDibbs scores or ratings of @entity158 (upon swallowing). At the one-month follow-up assessment no significant differences were found between the mouthwashes in MacDibbs scores or @entity158 ratings (upon swallowing). The analysis of the efficacy of the two mouthwashes revealed no significant differences in the time to heal (in days) from the @entity1161 -induced @entity33 . The findings from this trial provide important clinical information regarding cost analysis of @entity3137 management. Given that there is no significant difference in efficacy between micronized @entity5418 and salt _ soda, use of the less costly salt _ soda is prudent and cost-effective.
