Investigation of the presence of HPV related oropharyngeal and oral XXXX in Mozambique.

@entity1 @entity135 @entity986 @entity5 @entity957 @entity1799 @entity1082
BACKGROUND: @entity5 caused by the @entity1082 ) is endemic in East Africa. Recent, dramatic, increases in the incidence of @entity5 in the United States and Europe are linked to the same high risk HPV genotypes responsible for @entity5 . Currently, there is extremely limited data regarding the role of HPV in @entity135 in Africa. Evidence of HPV as an etiologic agent in @entity135 in Africa would have important prevention and treatment implications. METHODS: A retrospective single institution review of oral tongue and @entity957 diagnosed between 2005 and 2013 was performed. Individual case data for 51 @entity1 with biopsy proven @entity957 ( @entity957 ) from the oropharynx (n=22) and oral tongue (n=29) were identified. Formalin fixed, paraffin embedded biopsy samples were obtained and evaluated for @entity986 by immunohistochemistry and HPV genotype 16 specific oncogenes, E6 and E7, by PCR. RESULTS: All of the positive controls, but none of the oropharyngeal samples stained positively for @entity986 . Two of the oral tongue samples stained positive for @entity986 . None of the oropharyngeal or oral tongue cases demonstrated PCR products for @entity1799 E6 or E7. CONCLUSIONS: Though Mozambique has extremely high levels of HPV positive @entity5 this study demonstrates an absence of HPV positive oropharyngeal or oral @entity957 within biopsy samples from a single referral hospital in Maputo, the capital of Mozambique.
