[The effect of combined chemotherapy with UFT, cis-platinum and aclarubicin in metastatic XXXX ].

@entity1 @entity390 @entity41 @entity1313 @entity5 @entity75 @entity12169 @entity391 @entity3 @entity204
Thirteen @entity1 with metastatic @entity1313 were treated with two different chemotherapy regimens. Six @entity1 were treated with three antitumor drugs, UFT, @entity12169 (Group A) and the other seven @entity1 were treated with two antitumor drugs, @entity12169 (Group B). Initial response to each therapy was compared with the changes in @entity5 size on CT scan and clinical state before and after treatment. Five cases in Group A demonstrated complete remission and one case revealed partial response on CT scan. The @entity41 on CT scan at one month in one case of partial response also completely disappeared after three months. It was thought that there might have been an effect of UFT in this case. Four cases in Group B showed complete remission and three cases revealed partial response on CT scan. However, the CT findings in the three cases of partial response were unchanged on follow-up CT scan. Clinical state evaluated by Karnofsky scale did not deteriorate in Group A, while three cases showed a deteriorated Karnofsky scale in Group B. As side effects, there were mild myelosuppression, @entity390 and @entity391 in both Groups, which did not persist for a long time. The cause of @entity204 in both Groups was mainly recurrence of the @entity75 or @entity3 to other organs. It was thought that the effect in Group A was better than that in Group B as a result of these findings. The tissue concentration of @entity12169 was measured in six @entity1 , and the mean value was 0.558 micrograms/g at 15 min. This concentration was thought high enough to kill @entity5 cells.
