Segmental small intestinal allografts. II. Inadequate function with @entity205 immunosuppression: evidence of a XXXX .

@entity235 @entity205 @entity204 @entity6518
Terminal ileum was autografted (24 @entity235 ) or allografted (18 @entity235 ) as a 100-cm Thiry-Vella segment, and absorption, motility, and histology were studied. @entity235 with allografts were given @entity205 (CsA) 20 mg/kg/day. At a second operation 5 to 6 weeks after transplantation continuity of the nontransplanted intestine with the Thiry-Vella segment was restored. At a third operation 3 months after autografting, all the non-transplanted small intestine was excised. All technically successful autografts survived indefinitely, and the @entity235 weights were maintained at 88 +/- 0.6% (mean +/- SE) of preoperative weights by absorption from the autografted intestine. Administration of @entity205 to @entity235 with intestinal autografts produced a reversible impairment of intestinal absorption. @entity235 with allografts survived 63.3 +/- 15.5 days (mean +/- SE). @entity204 within 9 weeks of transplantation was from peritonitis secondary to graft rejection. @entity204 in long survivors was a consequence of inadequate intestinal absorption. In the first 4 weeks after transplantation absorption and motility of allografted Thiry-Vella segments was comparable to the intestinal autografts but allografts showed evidence of a @entity6518 . Large volumes of high protein-content fluid were lost from the allografted Thiry-Vella segments, and @entity235 with allografts became hypoalbuminemic.
