@entity652 induced by XXXX in strain A/J @entity19 lung correlate with time-integrated DNA adduct levels.

@entity12685 @entity9438 @entity71183 @entity2555 @entity19 @entity5 @entity3014 @entity2556 @entity47541 @entity9435 @entity652
The induction of DNA adducts and @entity652 in the lungs of strain A/J @entity19 has been investigated following the single i.p. administration of each of the following @entity2555 ( @entity2556 ): @entity9435 , @entity9438 , @entity3014 , @entity12685 , @entity71183 , and @entity47541 . DNA adducts were measured by 32P-postlabeling at times between 1 and 21 days following injection, while @entity652 were counted at 240 days after treatment. @entity9435 did not induce either DNA adducts or lung @entity652 at any of the doses examined. Each of the remaining @entity2556 induced both @entity652 and DNA adducts in a dose-dependent manner, with @entity9438 > @entity71183 > @entity47541 > @entity3014 > @entity12685 . DNA adducts reached maximal levels between 3 and 9 days after injection, followed by a gradual decrease. The time-integrated DNA adduct level (TIDAL) was calculated by numerically integrating the areas under the adduct persistence curves extrapolated to 240 days for each @entity2556 at each dose level. This value represents the effective total molecular dose of @entity2556 that was delivered to the lung DNA over the entire course of tumorigenesis. A strong correlation of @entity652 induction with the TIDAL values was observed for each @entity2556 . The @entity5 versus TIDAL value relationships were essentially identical for @entity71183 , @entity47541 , @entity3014 , and @entity12685 . The slope of this relationship for @entity9438 was markedly greater. The essentially identical induction of @entity652 as a function of TIDAL values for these @entity2556 suggests that the formation and persistence of DNA adducts determines their carcinogenic potency.
