Prediction of primary XXXX size and T-stage using micro-computed tomography in lumpectomy specimens.

@entity1 @entity1137 @entity0 @entity5 @entity513
BACKGROUND: Histopathology is the only accepted method to measure and stage the @entity0 size. However, there is a need to find another method to measure and stage the @entity5 size when the pathological assessment is not available. Micro-computed tomography. (micro-CT) has the ability to measure @entity5 in three dimensions in an intact lumpectomy specimen. In this study, we aimed to determine the accuracy of micro-CT to measure and stage the primary @entity5 size in breast lumpectomy specimens, as compared to the histopathology. MATERIALS AND METHODS: Seventy-two @entity1 who underwent lumpectomy surgery at the Massachusetts General Hospital Department of Surgery from June 2011 to September 2011, and from August 2013 to December 2013 participated in this study. The lumpectomy specimens were scanned using micro-CT followed by routine pathological processing. The maximum dimension of the invasive @entity0 was obtained from the micro-CT image and was compared to the corresponding pathology report for each subject. RESULTS: The invasive @entity5 size measurement by micro-CT was underestimated in 24 cases. (33%), overestimated in 37 cases. (51%), and matched it exactly in 11 cases. (15%) compared to the histopathology measurement for all the cases. However, micro-CT T-stage classification differed from histopathology in only 11. (15.2%) with 6 cases. (8.3%) classified as a higher stage by micro-CT, and 5 cases. (6.9%) classified as lower compared to histopathology. In addition, micro-CT demonstrated a statically significant strong agreement (k =0.6, P < 0.05) with pathological @entity5 size and staging for invasive @entity513 . (IDC) group. In contrast, there was no agreement. (k = -2, P = 0.67) between micro-CT and pathology in estimating and staging @entity5 size for @entity1137 . (ILC) group. This could be explained by a small sample size. (7) for ILC group. CONCLUSIONS: Micro-CT is a promising modality for measuring and staging the IDC.
