Correlation of XXXX : nationwide population-based case-control study.

@entity1 @entity483 @entity2023 @entity566 @entity565 @entity56 @entity1909 @entity4676
OBJECTIVE: Linkage between @entity566 and increased immune response activation in @entity4676 ( @entity4676 ) has been reported. We performed a matched case-control study to evaluate correlation between @entity56 and @entity4676 . METHODS: Data in this case-control study were from the Taiwan National Health Insurance Research Database. The sample comprised 845 2- to 18-year-old @entity1 with newly diagnosed @entity4676 in 2003   2007 and 3378 controls frequency matched with cases on age, sex, and urbanization level. Unconditional logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) of the association between @entity56 (e.g., @entity2023 , @entity483 , @entity565 , and @entity56 ), the number of allergic comorbidities, and @entity4676 . RESULTS: The majority (76.0%) of incident @entity4676 cases were @entity1 ; the 4 @entity56 strongly correlated with higher risk of @entity4676 . In a model simultaneously considering all 4 @entity56 , subjects with @entity2023 showed double the risk of @entity4676 (adjusted OR = 2.18, 95%CI 1.83   2.59; p < 0.0001); adjusted ORs were 1.82, 1.61, and 1.33, respectively, for @entity565 (95% CI 1.47   2.24; p < 0.0001), @entity1909 (95%CI 1.32   1.95; p < 0.0001), and @entity56 (95% CI 1.13   1.57; p < 0.001). Risk increased with number of comorbidities (p < 0.0001); this association was positively modified by age (p < 0.0001). CONCLUSIONS: Our data showed significant correlation between @entity56 and @entity4676 . Risk also increased with number of allergic comorbidities and with age. Further studies on the mechanism of neuroimmunology of @entity4676 are required.
