@entity417 and elevated systemic levels of @entity7 ( XXXX ).

@entity1 @entity8 @entity417 @entity66 @entity7 @entity5 @entity73 @entity519
BACKGROUND: Tissue @entity519 is a major stimulus for the up-regulation of @entity7 ( @entity7 ). @entity417 might theoretically impact on angiogenesis via @entity73 . We have investigated this hypothesis in @entity1 with solid @entity5 and @entity66 . @entity1 AND METHODS: 49 @entity1 with untreated locoregionally confined solid @entity5 of the head and neck, cervix, rectum and lung and 59 additional @entity1 with non-malignant diseases (36 normemic @entity1 without serious diseases and 23 @entity1 with @entity8 ) were enrolled and the impact of @entity417 on plasma @entity7 levels were determined. @entity7 was measured with a commercially available sandwich enzyme immunoassay technique. RESULTS: Plasma levels of @entity7 were 16.2 +/- 12.7 pg/ml in 36 normemic @entity1 without @entity5 , 49.2 +/- 34.5 pg/ml in 49 @entity1 with @entity5 (p < 0.001), and 89.9 +/- 67.8 pg/ml in 23 @entity1 with @entity8 (p = 0.001). @entity7 levels in @entity5 @entity1 were significantly correlated with hemoglobin (hb) levels and platelet counts (each p = 0.001), but not with type of @entity5 , stage, histology or age. @entity1 with @entity5 had higher plasma levels of @entity7 than @entity1 with non-malignant diseases in case of hb > or = 12 g/dl (33.1 +/- 17.5 vs 16.6 +/- 13.0 pg/ml, p < 0.001) and in case of hb between 11.0 and 11.9 g/dl (56.1 +/- 26.4 vs 18.5 +/- 14.5 pg/ml, p = 0.038). In case of a hb < 11 g/dl, plasma @entity7 levels were significantly elevated in @entity1 with and without @entity5 (67.0 +/- 47.5 vs 88.9 +/- 68.8 pg/ml, n.s.). In a multivariate model, a significant association between low hb levels and increased plasma levels of @entity7 was confirmed. In 16 @entity1 with @entity8 , changes in hb under erythropoietin treatment were inversely correlated with changes in plasma @entity7 levels with decreasing @entity7 after increase in hb (p = 0.01). CONCLUSIONS: Anemic @entity1 have elevated levels of @entity7 . The data suggest that @entity417 might impact on the progression of angiogenesis in @entity5 .
