The effect of topical XXXX in treatment of chronic anal fissure.

@entity1 @entity322 @entity12395 @entity3303 @entity158 @entity594 @entity4372 @entity460 @entity10
@entity12395 is the most common cause of anal @entity158 associated with internal anal sphincter @entity4372 . Reduction of hypertonocity is a special treatment for fissure healing. For this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy. However, both of these methods may cause a degree of @entity322 in some @entity1 . The uptake of medical therapies that create a reversible chemical sphincterotomy has recently become widespread. The aim of this prospective clinical trial study was to assess the effectiveness of @entity594 in healing anal fissure, a @entity460 channel blocker that reduces sphincter pressure. A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and 2% @entity3303 cream against 0.5% @entity594 cream for 4 weeks. 110 @entity1 were included in this study, 60 @entity1 in the @entity594 group and 50 @entity1 in the control group and the therapeutic outcome and side effects were recorded. Healing had occurred in 70% of @entity1 in the @entity594 group and in 12% of @entity1 in the control group after 4 weeks treatment (P < 0.005). Recurrence of symptoms occurred in four of healed @entity1 in the @entity594 group and three @entity1 in the control group in two months. The final result of @entity594 application after 12 months follow up was recurrence in 11 @entity1 (26.19%). Mild @entity10 occurred in four @entity1 (6.6%) of the @entity594 group. @entity1 in the @entity594 group showed significant healing and relief from @entity158 compared with @entity1 in the control group. Recurrence rate with @entity594 use in spite of control of predisposing factors such as constipation was significant. Another finding was low complication rate with this treatment.
