XXXX after medial frontal surgery: role of the supplementary motor area.

@entity1 @entity11280 @entity11 @entity86 @entity8408
BACKGROUND: @entity1 undergoing surgical resection of medial frontal lesions may present transient @entity86 that remain largely unpredictable. OBJECTIVE: To relate the occurrence of this speech deficit to the specific surgical lesion of the supplementary motor area ( @entity11280 ) involved during language tasks using fMRI. METHODS: Twelve @entity1 were studied using a verbal fluency task before resection of a @entity11 of the medial frontal lobe and compared with six healthy subjects. Pre- and postoperative MR variables including the hemispheric dominance for language, the extent of @entity11280 removal, and the volume of resection were compared to the clinical outcome. RESULTS: Following surgery, 6 of 12 @entity1 presented @entity8408 . The deficit was similar across @entity1 , consisting of a global reduction in spontaneous speech, ranging from a complete mutism to a less severe speech reduction, which recovered within a few weeks or months. The occurrence of the deficit was related to the resection of the activation in the @entity11280 of the dominant hemisphere for language (p < 0.01). Increased activation in the @entity11280 of the healthy hemisphere on the preoperative fMRI was observed in @entity1 with @entity86 . CONCLUSIONS: fMRI is able to identify the area at risk in the @entity11280 , of which resection is related to the occurrence of characteristic transient @entity86 . Increased @entity11280 activation in the healthy hemisphere suggested that a plastic change of @entity11280 function occurred in these @entity1 .
