Prognosis after lymph node recurrence in XXXX depends on age.

@entity3557 @entity1 @entity189
@entity3557 ( @entity3557 ) is a malignancy that has good prognosis especially among @entity1 up to 45 years of age; about half of the @entity1 are female and of childbearing age. Lymph node recurrence (LNR) occurs in 10%-14% of @entity1 but is considered to be associated with relatively good prognosis. The purpose of this study was to estimate the association between @entity1 age at primary operation, and the behavior of the disease after LNR. Between 1967 and 1994, 495 @entity1 underwent surgery for primary @entity3557 at the Department of Surgery, Helsinki University Central Hospital. There were 391 (79.0%) @entity1 and 104 (21.0%) @entity1 with a mean age of 44.5 years (range, 10.8-85.4 years). Fifty-eight @entity1 in whom LNR was the first clinical sign of persistent disease after complete clinical response to primary treatment were included in this series. At the time of primary operation, 37 (64.3%) of the 58 @entity1 who developed LNR were younger than 45 years of age and 21 @entity1 were older. The mean times to LNR in these groups were 42.0 months (range, 3.0-194.5 months) and 49.0 months (range, 3.6-209.0 months) respectively. @entity189 -specific 5-year survival after LNR was 100% (95% confidence interval [CI] 88.8%-100.0%) in @entity1 ages up to 45 years and 61.1% (40.5%-82.8%) in older @entity1 ; 10-year survival rates were 100%, and 41.3% (p < 0.0001), respectively. Relative survival at 10 years was 98.6% for @entity1 ages up to 45 years and 42.6% for older @entity1 (p = 0.0014). Using the Cox model it was shown that development of LNR after primary treatment has an independent highly significant negative effect on survival (p < 0.001) in @entity1 over 45 years of age. Prognosis of @entity3557 even after LNR on @entity1 ages up to 45 years at the time of the primary operation is almost parallel to the normal reference population, but in @entity1 over 45 years of age the prognosis is relatively poor.
