Medically inoperable stage I XXXX treated with radiotherapy alone.

@entity1 @entity712 @entity64 @entity101 @entity28 @entity6 @entity5 @entity583 @entity3 @entity453 @entity420
Definitive therapy for Stage I @entity420 consists of total abdominal hysterectomy and bilateral salpingo-oophorectomy. Pre- and/or post-operative radiotherapy (RT) is employed in selected @entity1 with poor prognostic factors such as poorly differentiated @entity5 or deep myometrial invasion by @entity5 . The results are reported of RT alone in 69 @entity1 with Stage I @entity420 who presented with severe, acute, and chronic medical illnesses which prevented surgical management of their disease. Sixty-three @entity1 (91.3%) were @entity28 or @entity101 . Twenty-seven @entity1 (39.1%) had @entity6 , 16 (23.2%) had @entity712 , and the remaining @entity1 had such conditions as @entity64 (17.4%), @entity453 (15.9%), and recent @entity583 (13.0%). The median age for this group of @entity1 was 72.0 years compared to 60.0 years for a concurrent group of 304 @entity1 with Stage I @entity420 treated at our institution with combined surgery and RT. RT consisted of intracavitary insertions alone (11 @entity1 ), intracavitary plus low dose external beam therapy (9 @entity1 ), and intracavitary therapy plus high dose external beam therapy (49 @entity1 , definitive RT). Younger @entity1 and those with poorly differentiated disease were treated more aggressively. The 5- and 10-year overall survival for all @entity1 was 76.8 and 33.3%, respectively. The 5- and 10-year disease-free survival was 88.1 and 82.4%, respectively. The 5-year overall and disease-free survival for the group of 49 @entity1 treated with definitive RT was 85.4% and 88.7% with 15/49 (30.6%) having poorly differentiated @entity5 . For the definitive therapy group, the 5- and 10-year disease-free survival was 94.3, 92.3, and 78.0% for grades I, II, and III, respectively. Analysis of patterns of failure showed that none of the @entity1 failed in the pelvis alone. Two out of 11 (18.2%) receiving intracavitary therapy alone and 3/49 (6.1%) receiving definitive RT failed in the pelvis with simultaneous @entity3 ( @entity3 ). Three @entity1 in the definitive RT group failed with @entity3 only. Severe complications occurred in 8 @entity1 (16%), all of whom received definitive RT.
