Interspecies comparative pathology of XXXX : relevance for treatment.

@entity1 @entity5 @entity2 @entity14 @entity3 @entity694 @entity560
Comparative pathology may serve as a practical tool for therapy by comparison of normal and abnormal structures of the digestive tract in animals and @entity1 . A better understanding of @entity694 as the most common solid @entity5 after @entity2 in the industrialized world is sought. In the so-called developed nations and in animals @entity694 is less frequent. The pathogenesis of @entity694 involves environmental and genetic factors. Several types of @entity14 can be discerned and the species distribution ranges from invertebrates to @entity1 . Colorectal neoplastic progression is species-specific. An intraspecies-specific @entity5 is also valuable. Alteration of signal transduction pathways and somatic mutations of oncogenes are described, as well as the occurrence, research and current treatment. @entity3 of @entity5 of the colon and of the rectum can be studied by intraspecies-specific comparison. Sections of this review deal with @entity560 and @entity5 and close with present therapies for @entity14 .
