Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for XXXX .

@entity1 @entity5 @entity260 @entity876 @entity14 @entity1086 @entity395
BACKGROUND/AIMS: @entity1086 is a @entity395 with dismal prognosis. However, lately improved survival has been reported after extended operation including liver resection and lymphadenectomy in addition to cholecystectomy. The aim of this study was to evaluate such a surgical strategy with and without adjuvant intra- and postoperative radiotherapy (IORT/EBRT). METHODOLOGY: 20 @entity1 underwent extended operation and the last 10 of them IORT/EBRT in addition. @entity5 staging was done using the TNM system, determination of histological @entity5 differentiation and immunohistochemical assessment of @entity876 , Ki67, metallothionein, deleted in @entity14 and carcinoembryogenic antigen in @entity5 tissue. RESULTS: There was no hospital mortality. @entity260 occurred in 3 @entity1 (15%). Actuarial 5-year survival was 47% in the radiotherapy group and 13% after operation only (NS). The corresponding figures for median survival are 28.8 and 20.2 months, respectively. Five @entity1 are still alive in the radiotherapy group. There was no difference in @entity5 stages of the two groups irrespective of the way of evaluation. CONCLUSIONS: The results suggest that extended operation for @entity1086 +/- IORT/EBRT can be done safely. The tendency to longer survival after adjuvant radiotherapy was not statistically significant.
