Synchronous primary XXXX : a multicenter review of 63 cases.

@entity1 @entity43 @entity1204 @entity233 @entity5 @entity8604 @entity1349
AIMS: To investigate clinicopathologic characteristics, therapeutic methods, and prognostic factors in @entity1 with synchronous primary @entity43 (SEOCs). METHODS: A retrospective review of 2 @entity5 registry databases in @entity233 was conducted to identify @entity1 diagnosed with SEOCs between January 1995 and December 2012. @entity1 with recurrent, metastatic, and metachronously occurring @entity5 were excluded. Multivariate logistic regression models were used to identify prognostic predictors for progression-free survival (PFS) and @entity1349 ( @entity1349 ). RESULTS: The analysis included 63 @entity1 with SEOCs. Seventy-six percent of the @entity1 had @entity1204 , and 60% of the @entity1 had @entity43 . Thirty-seven @entity1 (58.7%) had endometrioid/endometrioid histology. Optimal cytoreduction was obtained in 47 (74.6%) @entity1 . Recurrence developed in 17 @entity1 (27%). Multivariate analysis confirmed lymphovascular space invasion (LVSI) as an independent poor prognostic factor for @entity1349 ( @entity8604 , p = 0.045), whereas early-stage disease and optimal cytoreduction were found to be independent good prognostic factors for both PFS (OR 12.85, p<0.001 and OR 4.58, p = 0.004, respectively) and @entity1349 (OR 7.31, p = 0.002 and OR 2.95, p = 0.028, respectively). The 3- and 5-year @entity1349 rates were 74% and 69%, respectively. CONCLUSIONS: Our study demonstrated that optimal cytoreduction, early-stage disease, and LVSI are the most significant factors affecting survival in @entity1 with SEOC.
