High frequency of loss of allelic integrity at @entity3969 suppressor gene-1 locus in advanced @entity0 associated with @entity146 of the XXXX .

@entity1 @entity3821 @entity0 @entity7 @entity5 @entity146 @entity189 @entity5100 @entity8587 @entity2533 @entity3 @entity3969 @entity2856 @entity1558
BACKGROUND: The product of @entity3969 suppressor gene ( @entity8587 ), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study, @entity8587 allelic integrity was examined by Loss of Heterozygosity (LOH) studies in infiltrating @entity0 (n=60), @entity3821 ( @entity3821 ) (n=10) and @entity1558 (n=5) @entity1 , to determine its possible association with @entity5 progression. METHODS: LOH at the @entity8587 locus (11p13) as determined by PCR-RFLP for Hinf1 restriction site and was subsequently examined for its association with intratumoral expression of various growth factors i.e. @entity2533 , @entity5100 , @entity2856 and angiogenesis ( @entity7 and Intratumoral micro-vessel density) in @entity0 . RESULTS: Six of 22 (27.2%) genetically heterozygous of infiltrating @entity0 and 1 of 4 @entity3821 cases showed loss of one allele at @entity8587 locus. Histologically, the @entity5 with LOH at @entity8587 were @entity3821 ( @entity3821 ) and were of grade II and III. There was no correlation in the appearance of LOH at @entity8587 locus with age, @entity5 stage, menopausal status, chemotherapy status and lymph node @entity3 . The expression of factor @entity5100 and its receptor, @entity2856 was significantly higher in @entity189 having LOH at @entity8587 locus. A positive correlation was observed between the @entity2533 , @entity7 expression and IMD scores in infiltrating @entity189 . CONCLUSIONS: The current study indicates that the high frequency of loss of allelic integrity at @entity3969 suppressor gene-1 locus in high-graded @entity0 is associated with @entity146 of the @entity5 .
