Factors affecting survival following local, regional, or distant recurrence from localized XXXX .

@entity1 @entity5 @entity1066 @entity3 @entity320
BACKGROUND AND OBJECTIVES: Approximately one third of all @entity320 @entity1 will experience disease recurrence. Factors that affect @entity1 survival following local, regional, or distant first recurrences of localized @entity320 are the subject of this investigation. METHODS: Survival times for a total of 1,085 first recurrences from 4,568 localized @entity320 @entity1 were examined in relationship to @entity1 and disease factors by Cox regression. Nearly half (48.8%) of all first recurrences were regional, 21.8% were local, and 29.4% were distant recurrences. RESULTS: Survival following recurrence differed significantly by site of recurrence (local, regional, or distant; P < 0.0001). Within each site, the median survival time did not differ by time of recurrence following diagnosis. Significant @entity5 factors for survival following local recurrence included @entity5 thickness (P = 0.0263) and lesion location (P < 0.0001). For regional recurrences, survival was significantly related to @entity1066 (P = 0.0105) and whether the recurrence was combined with a local recurrence (P = 0.0429). Survival following distant @entity3 was related to number of distant sites (P < 0.0001) and whether a visceral site was involved (P < 0.0001). CONCLUSIONS: @entity1 and @entity5 characteristics predict survival following recurrence. Regardless of disease-free interval, long-term follow-up of @entity320 @entity1 is necessary. @entity1 experiencing distant @entity3 have the shortest median survival time compared to @entity1 experiencing local or regional recurrences.
