Role of nicotinic receptors in the lateral habenula in the attenuation of XXXX -induced prepulse inhibition deficits of the acoustic @entity427 response in @entity35 .

@entity3390 @entity935 @entity1239 @entity6959 @entity3826 @entity51 @entity1767 @entity35 @entity4944 @entity427
RATIONALE: Prepulse inhibition (PPI) refers to the reduction of the @entity427 response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In @entity35 , the PPI reduction induced by the @entity935 agonist @entity3826 can be reversed by systemic administration of @entity1239 . A high concentration of nicotinic receptors is found in the lateral habenula (LHb), an epithalamic structure with efferent projections to brain regions involved in the modulation of PPI, which has been shown to regulate the activity of midbrain @entity935 neurons. OBJECTIVES: The prospective role of nicotinic receptors in the LHb in the regulation of PPI was assessed in this study, using different pharmacological models of @entity51 . METHODS: Interactions between systemic @entity4944 and @entity1767 and intra-LHb infusions of @entity6959 (10  g/side) or @entity1239 (30  g/side) on PPI were analyzed in Experiments 1 and 2. Intra-LHb infusions of different @entity1239 doses (25, and 50  g/side) and their interactions with systemic administration of @entity4944 or @entity3390 on PPI were examined in Experiments 3 and 4. RESULTS: Infusions of @entity1239 into the LHb dose-dependently attenuated @entity4944 -induced @entity51 but had no effect on PPI disruptions caused by @entity3390 . Intra-LHb @entity6959 infusions did not affect PPI nor interact with dopaminergic manipulations. CONCLUSIONS: These results are congruent with previous reports of systemic @entity1239 effects on PPI, suggesting a role of the LHb in the attenuation of @entity51 caused by the hyperactivity of @entity935 systems.
