[Treatment of XXXX with @entity1712 ( @entity5072 ) using topical @entity1140 : Two cases].

@entity1 @entity1712 @entity483 @entity455 @entity11782 @entity548 @entity5072 @entity272 @entity1140 @entity1462
BACKGROUND: @entity5072 ( @entity5072 ) is a rare disease, currently considered a benign @entity455 of unknown etiology, and whose treatment is still unclear and challenging. @entity1 AND METHODS: Two @entity1 in their thirties consulted for itchy lesions of the right ear. Both presented with a @entity548 papulonodular infiltration of the auricle, with a nodule at the entrance to the external auditory canal in the first @entity1 . Laboratory tests showed no abnormalities and in particular no @entity1712 or elevated serum immunoglobulin E. In both cases, histology of lesional skin showed @entity455 with thick-walled vessels lined by plump endothelial cells, protruding into the lumen, together with a mixed dermal inflammatory infiltrate consisting primarily of eosinophils and lymphocytes. A diagnosis of @entity5072 was made in both @entity1 based on clinical and histological features. MRA revealed no underlying @entity1462 in both cases. @entity1 started treatment with 0.1% @entity1140 ointment twice daily. The @entity11782 sensation and bleeding had completely subsided within two weeks and the reddish infiltration and nodules had practically disappeared after two months of topical @entity1140 . Continuous application resulted in no recurrence at 6 months of follow-up. DISCUSSION: Treatment of @entity5072 is still poorly standardized due to doubts concerning the pathophysiology of this rare condition and the small number of available studies. Topical @entity1140 was originally developed for the treatment of moderate to severe @entity483 because of its anti-inflammatory and immunomodulatory properties. Recent studies suggest that this drug may be effective in treating other forms of inflammatory @entity272 . Our two observations suggest that @entity1140 ointment also represents potentially valuable treatment in AHLE.
