Short-term and long-term effect of diaphragm biofeedback training in XXXX : an open-label, pilot, randomized trial.

@entity1 @entity34070 @entity304 @entity1269 @entity354
UNASSIGNED: This study investigated the effectiveness of diaphragm biofeedback training (DBT) for @entity1 with @entity354 ( @entity354 ). A total of 40 @entity1 with @entity354 treated at the Peking Union Medical College Hospital between September 2004 and July 2006 were randomized to receive DBT and @entity34070 proton pump inhibitor (PPI) or @entity34070 alone. The DBT + @entity34070 group received DBT during the 8-week initial treatment; the @entity34070 group did not. During the 6-month follow up, all @entity1 took acid suppression according to their @entity304 , and the @entity1 in the DBT + @entity34070 group were required to continue DBT. The primary outcome (used for power analysis) was the amount of acid suppression used at 6 months. Secondary outcomes were @entity304 , health-related quality of life (HRQL), and esophageal motility differences after the 8-week treatment compared with baseline. Acid suppression usage significantly decreased in the DBT + @entity34070 group compared with the @entity34070 group at 6 months (P < 0.05). At 8 weeks, @entity304 and @entity354 -HRQL were significantly improved in both groups (P < 0.05), without difference between them. @entity1269 ( @entity1269 ) and gastroesophageal junction pressure (GEJP) significantly increased in the DBT + @entity34070 group (P < 0.05), but without change in lower esophageal sphincter (LES) pressure. There was no significant change in @entity1269 , GEJP, and LES pressure compared with baseline in the @entity34070 group. In conclusion, long-term DBT could reduce acid suppression usage by enhancing the anti-reflux barrier, providing a non-pharmacological maintenance therapy and reducing medical costs for @entity1 with @entity354 .
