The pattern of XXXX local recurrence after radiation and salvage cryoablation.

@entity1 @entity263 @entity322 @entity146 @entity5 @entity9292
OBJECTIVE: We assessed the pattern of local recurrence after salvage cryoablation of the prostate, and the impact of local recurrence on intermediate-term outcome. METHODS: One hundred twenty-two @entity1 who underwent salvage cryoablation were studied after a mean follow-up of 56 months. Serial prostate biopsy was carried out after cryoablation. The histopathology of prostate biopsies before and after cryoablation were compared. The prognostic value of post-cryoablation biopsy was assessed with the Cox regression method. RESULTS: 23.1% of @entity1 had a positive biopsy for @entity263 following salvage cryoablation. Most @entity5 recurrences occurred in the apex (51.5%), base (21.2%) and seminal vesicles (18.2%). The presence of @entity5 at the base of the prostate was found to be a prognostic factor for eventual biochemical failure. Overall 5-year biochemical disease-free survival (bDFS) was 28%, however @entity1 with @entity5 at the base of the prostate had a 5-year bDFS of 0%. CONCLUSION: @entity5 occurred in areas where @entity146 freezing was avoided as it might result in serious problems (e.g., @entity9292 and @entity322 ). Post-cryoablation biopsies and the location of persistent disease are of prognostic value.
