Transrectal periprostatic XXXX injection anesthesia for transrectal prostate biopsy: a prospective study.

@entity1 @entity263 @entity3303 @entity158 @entity1486 @entity616
Transrectal ultrasound (TRUS)-guided biopsy remains the mainstay of the diagnosis of @entity263 . Although this diagnostic method is a safe procedure and well tolerated by most @entity1 a significant number of @entity1 report discomfort and @entity158 during prostate biopsy. In order to define the best method of anesthesia, many studies, in which different methods were compared, have been performed. To determine the effectiveness of local injection anesthesia in TRUS-guided prostate biopsy, we designed and performed this prospective study in order to evaluate the utility of @entity616 for @entity158 management. A total of 100 @entity1 who had elevated total @entity1486 and/or abnormal digital rectal examination (DRE) were included in this study. Half of the @entity1 received periprostatic injection anesthesia (group I) and the remaining half received placebo (group II). @entity1 received 10 cm3 (5 cm3 each side) 1% @entity3303 injected into the periprostatic nerve plexus under transrectal ultrasonic guidance. @entity158 during biopsy was assessed using a 10-point modified visual analog scale (VAS). In groups I and II, mean @entity1 age was 66.8+2.5 and 65.6+11.5 y, mean tPSA was 7.87+/-3.6 and 11.3+/-1.7 ng/ml, mean biopsy duration was 6.5+/-2.5 and 6.6+/-2.2 min and mean @entity158 score during TRUS-guided biopsy was 1.46+/-2.2 and 4.5+/-2.1, respectively. No statistically significant difference was observed with respect to age, tPSA and mean biopsy duration between these groups. Mean @entity158 VAS score was statistically or significantly better (P=0.0001) in the @entity3303 injection group (group I), and furthermore no @entity1 had a VAS @entity158 score > or =5 in this group. Only minor and transient complications occurred in both groups. This study reinforces the usage of @entity616 as a standard method of @entity158 management during TRUS-guided prostate biopsy, because it is simple, safe, uncostly and significantly effective without requiring additional time.
