Clinical characteristics influencing age at onset in XXXX .

@entity1 @entity162 @entity4697 @entity146 @entity167 @entity914 @entity835 @entity161 @entity74 @entity716
BACKGROUND: Age at onset of @entity716 may carry clinical significance across @entity914 and appears to be associated with specific @entity74 . METHODS: We used the Structured Clinical Interview for Diagnostic and Statistical Manual of @entity146 , Fourth Edition (DSM-IV) to examine clinical characteristics contributing to age at onset variability in @entity1 with @entity161 (n = 80), @entity914 (n = 61), and @entity162 with @entity716 features (n = 92). RESULTS: Age at onset did not differ across DSM-IV diagnostic groups. Multiple regression analyses revealed that comorbid lifetime cannabis, but not @entity167 , abuse/dependence was associated with a statistically significant 3 years earlier age at onset of @entity716 . @entity1 developed @entity835 /dependence an additional 3 years before @entity716 . @entity1 with comorbid lifetime @entity4697 also had a 4-year earlier age at onset of @entity716 . The effects of @entity4697 and @entity835 /dependence were independent of one another. CONCLUSIONS: Early onset of @entity716 , regardless of the specific DSM-IV diagnosis, is characterized by differential clinical features, notably a history of lifetime @entity835 /dependence. @entity4697 comorbidity is also associated with earlier age at onset of @entity716 . Our findings indicate that examination of clinical and biological characteristics of @entity1 with @entity716 regardless of DSM-IV diagnosis can uncover relevant information.
