Botulinum A neurotoxin inhibits non-cholinergic synaptic transmission in XXXX spinal cord neurons in culture.

@entity1 @entity19 @entity11849 @entity116 @entity616
The effects of botulinum A neurotoxin and @entity116 toxin were studied in cultured @entity19 spinal cord neurons. In approximately 60% of the neurons (n = 150), botulinum A neurotoxin caused paroxysmal depolarizing events. In two cells hyperpolarizing shifts were observed. The pattern of the burst-like activity varied in shape and frequency in individual cells. Between the paroxysmal events, ongoing synaptic activity could be recorded. The other 40% of the treated neurons did not develop a characteristic pattern of bursts, but there was a decrease in frequency of synaptically generated events. In contrast to botulinum A neurotoxin, @entity116 toxin invariably produced well organized paroxysmal events without any synaptic activity between them. At later stages botulinum A neurotoxin and @entity116 toxin blocked inhibitory and excitatory postsynaptic potentials in all neurons studied. These results have demonstrated, for the first time using electrophysiological techniques, that botulinum A @entity616 both excitatory and inhibitory synaptic transmission in the @entity1 central nervous system. There are however differences between these effects of botulinum A neurotoxin and the actions of @entity116 toxin on these cells. It is suggested that at the femtomolar range @entity116 toxin blocks selectively central inhibitory systems and botulinum A neurotoxin the motor endplate. At the @entity11849 affect many if not all, transmitter systems.
