Flow cytometry for followup examinations of conservatively treated low stage XXXX .

@entity1 @entity1377 @entity5 @entity1185 @entity189 @entity150 @entity25390
A series of 26 conservatively treated @entity1 with low stage @entity150 was examined later by outpatient cystoscopy, conventional cytology and flow cytometry. Based on those findings the @entity1 were separated into 5 groups. In the 4 @entity1 in group 1 all findings persistently were negative. The 4 @entity1 in group 2 had initially normal cystoscopy with progressively more abnormal flow cytometry and intermittently positive cytology; they subsequently suffered @entity5 . The 10 @entity1 in group 3 had positive cystoscopy and flow cytometry, and intermittently positive cytology. The 6 @entity1 in group 4 had negative cystoscopy with intermittently positive cytology and persistently positive flow cytometry. In all 6 cases flow cytometry was more sensitive than conventional cytology in detecting early and, sometimes, @entity25390 . In the 2 @entity1 in group 5 cystoscopically visible @entity1185 and low grade @entity1377 were found with negative flow cytometry and negative or suspicious cytology. The @entity5 in these 2 @entity1 were believed to be composed principally of benign or atypical epithelium, with too few malignant cells to be detected by present flow cytometry techniques. Our preliminary results suggest that flow cytometry may be a valuable tool for followup of @entity1 who have had conservatively treated low stage @entity150 and are at risk for development of @entity189 . In addition, the techniques may be used to monitor changes in the proportion of benign and malignant cells and, thus, can be of help in following the course of newly forming @entity1185 , @entity1377 or @entity189 in situ in @entity1185 or flat epithelium.
