Inhibitory effect of Platycodon grandiflorum on XXXX and @entity61 immune responses in a @entity19 model of @entity18580 -induced @entity272 .

@entity483 @entity12782 @entity59 @entity18580 @entity19 @entity61 @entity6527 @entity46089 @entity358 @entity58 @entity272 @entity9749
BACKGROUND: Platycodon grandiflorum is a traditional Asian medicine that is used to treat @entity358 . OBJECTIVE: to investigate the effects of P grandiflorum in vivo in an animal model of @entity483 ( @entity483 ), with particular emphasis on its effects on @entity46089 and @entity61 immune responses. METHODS: we established a model of @entity483 -like @entity272 in NC/Nga @entity19 . After oral administration of P grandiflorum, we measured cytokine and immunoglobulin profiles along with histologic examination of skin. RESULTS: P grandiflorum was nontoxic in a @entity18580 -induced model of @entity483 -like @entity272 in NC/Nga @entity19 . @entity483 symptoms in @entity272 improved after oral administration of P grandiflorum. IgE secretion was significantly downregulated in P grandiflorum-treated animals, accompanied by decreased levels of @entity58 and @entity6527 and increased serum levels of @entity12782 and @entity9749 . In isolated splenocytes, the production of the @entity46089 cytokines @entity12782 and interferon-y was upregulated by P grandiflorum, whereas the levels of the @entity61 cytokines @entity58 and @entity59 were downregulated in a @entity19 model of @entity483 -like @entity272 . CONCLUSIONS: these results suggest that P grandiflorum inhibits the development of @entity483 -like @entity272 in NC/Nga @entity19 by suppressing the @entity61 cell response and increasing the @entity46089 cell responses. Our results indicate that P grandiflorum is safe and effective as a natural herbal medicine for the treatment of @entity483 -like @entity272 .
