The effects of diltiazem and metoprolol in XXXX due to amitriptyline intoxication.

@entity1 @entity137 @entity35 @entity1162 @entity1370
BACKGROUND AND OBJECTIVE: Amitriptyline, a frequently used tricyclic antidepressant agent, has powerful @entity1370 effects especially in high doses. Serum and urine levels of amitriptyline dosages are not correlated with severity of @entity137 ; therefore, it increases the importance of electrocardiography (ECG) abnormalities. The prolongation of QTc can be a predictive marker for @entity1370 . Hence, in this study, it is aimed to evaluate possible effects of metoprolol and diltiazem in amitriptyline @entity137 . MATERIALS AND METHODS: The @entity35 were separated into four groups. First one was control group, the second was the amitriptyline + saline group, third one was the amitriptyline + metoprolol group, and forth one was the amitriptyline + diltiazem group. ECG were recorded on @entity35 under anesthesia. RESULTS: In amitriptyline group, QTc duration was prolonged compared with all other groups. The prolongation of QTc was shorter in amitriptyline + metoprolol group and amitriptyline + diltiazem group than amitriptyline group (p < 0.01 and p < 0.01, respectively). CONCLUSION: According to the results, it is possible to report ameliorating effects of both metoprolol and diltiazem on @entity1162 related with amitriptyline intoxication. With further studies, these agents may be used for amitriptyline @entity137 and besides, they may be used for @entity1 in cardiovascular risk groups who take amitriptyline treatment regularly.
