Treatment of XXXX with fast neutron radiotherapy.

@entity1 @entity137 @entity66 @entity5 @entity14253 @entity3
OBJECTIVE: To evaluate the efficacy of fast neutron radiotherapy for the treatment of @entity14253 . DESIGN: Retrospective analysis. SETTING: University of @entity5 Center, Neutron Facility, Seattle. @entity1 : The medical records of 279 @entity1 treated with curative intent using fast neutron radiotherapy at the University of @entity5 Center were reviewed. Of the 279 @entity1 , 263 had evidence of gross @entity66 at the time of treatment (16 had no evidence of gross @entity66 ), 141 had @entity5 of a major salivary gland, and 138 had @entity5 of minor salivary glands. The median follow-up period was 36 months (range, 1-142 months). MAIN OUTCOME MEASURES: Local-regional control, cause-specific survival, and freedom from @entity3 . RESULTS: The 6-year actuarial cause-specific survival rate was 67%. Multivariate analysis revealed that low group stage (I-II) disease, minor salivary sites, lack of skull base invasion, and @entity66 were associated with a statistically significant improvement in cause-specific survival. The 6-year actuarial local-regional control rate was 59%. Multivariate analysis revealed size 4 cm or smaller, lack of base of skull invasion, prior surgical resection, and no previous radiotherapy to have a statistically significant improved local-regional control. Sixteen @entity1 without evidence of gross @entity66 had a 100% 6-year actuarial local-regional control. The 6-year actuarial freedom from @entity3 rate was 64%. Factors associated with decreased development of systemic metastases included negative lymph nodes at the time of treatment and lack of base of skull involvement. The 6-year actuarial rate of development of grade 3 or 4 long-term @entity137 (using the Radiation Therapy Oncology Group and European Organization for Research on the Treatment of @entity5 criteria) was 10%. No @entity1 experienced grade 5 toxic effects. CONCLUSIONS: Neuron radiotherapy is an effective treatment for @entity1 with @entity14253 who have gross @entity66 and achieves excellent local-regional control in @entity1 without evidence of gross disease.
