DW-MRI ADC values can predict treatment response in @entity1 with locally advanced XXXX undergoing neoadjuvant chemotherapy.

@entity1 @entity0 @entity66 @entity5 @entity1259 @entity74 @entity1205
The purpose of this study was to evaluate the importance of diffusion-weighted magnetic resonance imaging (DW-MRI) apparent diffusion coefficient (ADC) values to predict treatment response to neoadjuvant chemotherapy (NCT) in @entity1 with locally advanced @entity0 (LABC). Thirty-two @entity1 with LABC underwent 2-4 cylces of NCT ( @entity1205 and @entity1259 ). The DW-MRI scans were performed within one week prior to chemotherapy and after the first course of treatment, respectively. Accordingly, @entity5 volumes, changes in @entity5 ADC values, and their degree of correlation were analyzed. The overall response (OR) was observed in 62.5% (95% CI, 45.7-79.3%) of @entity1 after 2 cycles of NCT. The clinical complete response (CR) rate and pathological CR (pCR) rate were 15.6 and 9.4%, respectively. The @entity66 ( @entity66 ) rate was 34.4% (11 @entity1 ), and @entity74 ( @entity74 ) was observed in only one @entity1 (3.1%). After the first cycle of NCT, the ADC values in the CR + PR group significantly increased (P < 0.001). The initial ADC values before chemotherapy in the OR group were significantly lower than those in the @entity66 + @entity74 group (P < 0.001). The initial ADC values and the changes in @entity5 volume after chemotherapy were negatively correlated (r = -0.58, P = 0.02). The lower the initial @entity5 ADC value was the more obvious the decrease in @entity5 volume after chemotherapy. The changes in ADC values of @entity5 after chemotherapy and the changes in @entity5 volume were positively correlated (r = 0.96, P < 0.001). After chemotherapy, the greater the change in ADC value, the more the @entity5 volume was reduced. Using the initial ADC values of @entity0 and the early changes in ADC values after NCT, we may be able to predict @entity5 response to chemotherapy. @entity5 with low initial ADC values may be sensitive to chemotherapy; @entity5 with significantly increasing ADC values early after chemotherapy may be sensitive to chemotherapy.
