Inhibitory effect of endostar in combination with radiotherapy in a XXXX model of @entity1 CNE2 @entity189 .

@entity1 @entity19 @entity5 @entity189 @entity1611
The inhibitory effects of Endostar in combination with radiotherapy in BALB/c @entity19 model of @entity1 CNE2 @entity189 and the mechanism were investigated. In @entity19 model of CNE2 @entity189 , the inhibitory rate and the sensitizing enhancement ratio (E/O) were calculated according to the @entity5 volumes in different groups. The expression of microvascular density (MVD) in @entity5 tissues was examined by using immunohistochemistry staining. The transcription of @entity1611 gene was detected by using RT-PCR. The inhibitory rate in Endostar+ radiotherapy group was higher than in other groups. In Endostar+radiotherapy group, the @entity5 volume was significantly decreased and the E/O ratio was 2.335, suggesting that Endostar could be a radiosensitizer. The expression of MVD of @entity5 tissues in Endostar+radiotherapy group was reduced significantly. The expression of the MVD in treatment groups was significantly different from that in control group (P<0.05). Compared to other groups, @entity1611 mRNA expression in Endostar+radiotherapy group was decreased remarkably. Endostar in combination with radiotherapy significantly inhibited the growth of CNE2 @entity5 . The combination therapy decreased the expression of @entity1611 , and inhibited @entity5 angiogenesis and proliferation. When combined with radiotherapy, Endostar acted as a radiosensitizer.
