Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in XXXX .

@entity35 @entity18670
Our objective was to study whether islet amyloid polypeptide ( @entity18670 ) produces satiety by an endocrine mechanism. We used a @entity35 model to determine whether postprandial plasma levels of @entity18670 are comparable to those required to inhibit feeding when @entity18670 is administered by continuous intravenous infusion. Food intake in @entity35 with aortic catheters increased plasma @entity18670 levels from a fasting level of 10.8 +/- 0.5 pM to a peak level of 19.0 +/- 1.0 pM at 2.2 +/- 0.5 h. In @entity35 with jugular vein and aortic catheters, the threshold intravenous dose for @entity18670 suppression of feeding was between 1 and 3 pmol . kg-1 . min-1. The 3 pmol . kg-1 . min-1 dose decreased 4-h intake by approximately 25% by decreasing meal frequency rather than meal size. This dose increased plasma @entity18670 by approximately 24 pM. These results suggest that postprandial plasma levels of @entity18670 are not quite sufficient to independently produce satiety.
