XXXX -related @entity1017 : genetic and nongenetic predictors.

@entity1 @entity7601 @entity5320 @entity9330 @entity1873 @entity1017 @entity161 @entity2252 @entity734 @entity1090
OBJECTIVE: A serious side effect of atypical antipsychotics is increased body weight, which leads to further morbidity and nonadherence to medication. It has been suggested that both genetic and nongenetic variables may influence antipsychotics-related @entity1017 . This study aimed to simultaneously explore the effects of multiple candidate genes and environment factors on body weight of @entity161 @entity1 who received @entity1090 , a commonly used atypical antipsychotic agent. METHODS: One hundred twenty-three ethnically Han Chinese inpatients with acutely exacerbated @entity161 were given @entity1090 monotherapy for up to 42 days. Body weight and clinical manifestations were assessed biweekly. Drug efficacy was measured by the Positive and Negative Syndrome Scale (PANSS), and safety was evaluated by the Extrapyramidal Symptom Rating Scale (ESRS) and the UKU Side Effect Rating Scale. We collected body weight as the response value. Potential prognostic factors were baseline body weight, age, sex, diagnosis subtypes, @entity1090 dosage, PANSS total scores, treatment duration (weeks 0-6), and 15 genetic variants [across 10 candidate genes: @entity1873 , @entity7601 , @entity9330 , 5-HT6, D1, D2, D3, and alpha1-adrenergic receptors, @entity2252 ( @entity2252 ), and @entity5320 ( @entity5320 )]. Because there were repeated assessments, multiple linear regression with the generalized estimating equation (GEE) method was used to adjust the within-subject @entity734 . RESULTS: Of 15 genetic polymorphisms examined, @entity7601 102-T/C, @entity9330 -759-C/T, 5-HT6 267-C/T, @entity2252 66-Val/Met, and @entity5320 188-C/T significantly influenced body weight, and so did baseline body weight, age, gender, @entity161 subtype, and treatment duration and efficacy. CONCLUSIONS: These results suggest that numerous genetic and nongenetic factors affect antipsychotics-related @entity1017 .
