Hepatic organelle pathology in XXXX and the response to low-dose @entity2361 therapy.

@entity2835 @entity1 @entity920 @entity2361
1. Analytical subcellular fractionation in combination with enzymic microanalysis has been used to investigate the hepatic organelle pathology of @entity2835 . Activities of plasma membrane and lysosomal enzymes in hepatic needle biopsies were increased, but marker enzymes for other organelles were normal. 2. Seven @entity1 were treated with a low dose of @entity2361 , 250 mg daily, over a 3--6 month period. The initially raised serum alkaline phosphatase and IgM levels were significantly reduced. In four @entity1 with markedly elevated hepatic @entity920 there was a small decrease, but urinary @entity920 excretion was unaltered. Hepatic organelle pathology was significantly improved. 3. No serious side-effects were noted and it is suggested that a controlled trial of low-dose @entity2361 therapy is indicated in @entity1 with @entity2835 .
