Associations between XXXX history and lumbar MRI findings.

@entity1 @entity5752 @entity1643 @entity612 @entity5040 @entity615 @entity158
STUDY DESIGN: Retrospective monozygotic twin cohort study. OBJECTIVES: Our goal was to investigate the associations between different spinal MRI findings and current, past year, and lifetime @entity1643 after adjusting for occupational physical loading, smoking, genetics, and early family influences. SUMMARY OF BACKGROUND DATA: The role of spinal pathology in back symptoms continues to be controversial. METHODS: The study @entity1 consisted of 115 monozygotic male twin pairs 35 to 69 years of age. The qualitatively assessed MRI parameters were as follows: disc height, bulging, herniations, anular tears, @entity5040 , @entity612 , and endplate changes. Signal intensity was measured quantitatively. RESULTS: After controlling for age, disc height was associated with all @entity615 variables studied and anular tears with @entity5752 frequency and intensity during the 12 months before imaging. Both were associated with lifetime frequency of @entity1643 interfering with daily activities, disability, and intensity of the worst lifetime @entity158 episode. Other MRI findings did not explain the various symptom histories. Adjusting for physical loading in the past 12 months increased the associations of anular tears and " @entity1643 parameters. After controlling for genotype and other familial influences, the within-pair differences in disc height and anular tears accounted for 6% to 12% of the total variance in the within-pair differences of @entity1643 variables. CONCLUSION: These findings raise new questions about the underlying mechanisms of @entity5752 . The sensitivities of the only significant MRI parameters, disc height narrowing and anular tears, are poor, and these findings alone are of limited clinical importance.
