XXXX , @entity11602 and sIL-4R in renal, meningeal and @entity1907 ; a 2 year study of @entity1 and contacts.

@entity11602 @entity1 @entity2028 @entity2842 @entity1906 @entity3646 @entity378 @entity1907
The role of Th2 cytokines and Th2-associated chemokines in @entity378 ( @entity378 ) remains controversial, though in Mexico a polymorphism causing increased production of @entity2842 is a risk factor. We studied levels of the Th2-associated chemokines @entity2842 and @entity11602 , circulating soluble @entity3646 receptors (sIL-4R), @entity3646 and the inhibitory splice variant of @entity3646 ( @entity3646  2) in a cohort of @entity1 with @entity1907 and their healthy contacts. These were followed for 2 years during which time 10 contacts developed @entity1907 . Results were compared with measurements made in @entity1906 , and in disease controls with @entity2028 that have large Th2 components. In these disease controls both chemokines were significantly raised. They were also very significantly raised in all forms of @entity378 , irrespective of age or disease site. Levels of @entity11602 were raised least in @entity1906 , and most in pulmonary @entity1 with long histories, when levels were similar to those in disease controls. Levels of @entity2842 , although also raised in all three forms of @entity378 , were negatively correlated with @entity11602 . We found that levels of sIL-4R were strikingly reduced in all forms of @entity378 , particularly meningeal. Contacts who progressed could not be distinguished from contacts who remained healthy at 2 years in terms of @entity3646 , sIL-4R, @entity2842 or @entity11602 . However contacts had raised expression of @entity3646  2 as previously found. These results indicate vigorous and previously unrecorded activity within the Th2 axis, and further investigation is warranted.
