XXXX genes regulate noise-induced @entity393 .

@entity2428 @entity588 @entity1836 @entity393 @entity204
Proteins of the @entity588 family have been implicated in control of apoptotic pathways modulating neuronal cell @entity204 , including noise-induced @entity393 . In this study, we assessed the expressions of anti- and proapoptotic @entity588 genes, represented by @entity1836 and @entity2428 following noise exposures, which yielded temporary threshold shift (TTS) or permanent threshold shift (PTS). Auditory brainstem responses (ABRs) were assessed at 4, 8, and 16 kHz before exposure and on days 1, 3, 7, and 10 following exposure to 100 dB SPL, 4 kHz OBN, 1 hr (TTS) or 120 dB SPL, 4 kHz OBN, 5 hr (PTS). On day 10, subjects were euthanized. ABR thresholds increased following both exposures, fully recovered following the TTS exposure, and showed a 22.6 dB (4 kHz), 42.5 dB (8 kHz), and 44.9 dB (16 kHz) mean shift on day 10 following the PTS exposure. PTS was accompanied by outer hair cell loss progressing epically and basally from the 4-kHz region. Additional animals were euthanized for immunohistochemical assessment. @entity1836 was robustly expressed in outer hair cells following TTS exposure, whereas @entity2428 was expressed following PTS exposure. These results indicate an important role of the @entity588 family proteins in regulating sensory cell survival or @entity204 following intense noise. @entity1836 plays an essential role in prevention of sensory cell @entity204 following TTS levels of noise, and PTS exposure provokes the expression of @entity2428 and, with that, cell @entity204 .
