Is @entity1286 -induced sedation synonymous with @entity1337 during intravenous XXXX titration?

@entity1 @entity1337 @entity23169 @entity158 @entity1286
BACKGROUND: Postoperative @entity1286 titration frequently induces sedation. The assumption is made that @entity1 sleep when their @entity158 is relieved. Some @entity1 complain of persistent @entity158 when they awake. We studied the time-course of sedation and @entity1337 to understand the determinants of @entity1 ' sleep during @entity1286 titration. METHODS: Seventy-three @entity1 requiring @entity1286 titration in a post-anaesthetic care unit after major surgery, were studied. Fifty-two @entity1 slept (Sleep group) and 21 did not (Awake group). When a @entity1 slept during titration, @entity1286 was discontinued. Visual analogue @entity158 scale (VAS), Ramsay score (RS), and the bispectral index (BIS) were recorded at the beginning of titration (STonset), at sleep onset (STsleep), then 5, 10, 20, and 30 min afterwards ( @entity23169 ). RESULTS: In the Sleep group, mean (SD) RS increased from 1.7 (0.4) to 2.4 (0.6) (P<0.05 vs STonset) and BIS decreased from 95 (5.0) to 89.8 (10.2) between STonset and STsleep (P<0.05), RS remained stable thereafter. Conversely, RS and BIS remained unaltered in the Awake group. The reduction in VAS was comparable between groups (from 78 (17) to 39 (21), and from 64 (16) to 30.4 (11), respectively). Even though mean (SD) VAS was 39 (21) at @entity23169 in the Sleep group, 13 @entity1 (25%) maintained a VAS above 50 mm. CONCLUSION: We observed dissociated effects of @entity1286 on the time-course of sedation and @entity1337 with sedation occurring first, followed by @entity1337 . Therefore, @entity1286 -induced sedation should not be considered as an indicator of an appropriate correct level of @entity1337 during i.v. @entity1286 titration.
