[Targeting the gene of @entity413 metabolism for the treatment of advanced XXXX ].

@entity3175 @entity5 @entity11 @entity1245 @entity19981 @entity463 @entity413
Loss of chromosomes is a recurrent event in @entity5 . Chromosome-10 losses occur with @entity5 progression and characterize advanced @entity11 . This chromosome carries many genes involved in @entity413 metabolism. Hexokinase (HK) gene is located on chromosome-10. Hexokinase enzymatic activity is decreased in @entity463 . Hexokinase enables @entity413 entry into glycolysis and is critical for these highly glycolytic @entity5 . These enzyme is either free in the cytosol or bound to the mitochondrial outer membrane. Disturbance of HK binding to mitochondria by @entity19981 led to inhibition of cells and xenografted- @entity11 growth. Hexokinase bind to a mitochondrial porin which involved peripheral @entity1245 receptors. Inhibition of HK and peripheral @entity1245 receptors by @entity19981 and @entity3175 led to synergistic antitumoral activity in xenografted @entity11 . Co-inhibition of these two receptors will lead to a decrease in glycolysis, often elevated in these @entity5 , without modifying energetic metabolism of normal cells.
