Pattern and prognosis of liver function test abnormalities during parenteral nutrition in XXXX .

@entity1 @entity1560 @entity648 @entity409 @entity29
The pattern of liver function test abnormalities was examined during total parenteral nutrition (TPN), using both dextrose and fat emulsions as caloric sources, in 92 @entity1 with @entity29 . Seventy-two @entity1 had completely normal tests before TPN while 20 had one or more abnormal liver function tests before TPN was started. Serum @entity648 levels were normal in all @entity1 before TPN; within 2 weeks on TPN, 25% of @entity1 had elevated @entity648 levels. Serum alkaline phosphatase rose to values above normal in 25% of @entity1 with normal starting values but did not change in those with abnormal baseline liver function tests. Elevations of SGPT were characteristically more pronounced than were elevation of SGOT. After 2 weeks of TPN, mean serum SGOT rose from 15 to 26 IU per liter (p less than 0.01) in @entity1 with normal baseline values and from 28 to 50 IU per liter in those with abnormal baseline values. Elevations of serum SGPT were most common, affecting 25% of @entity1 with normal baseline. The mean SGPT value rose from 13 to 38 IU per liter (p less than 0.01) at 1 week of TPN. In @entity1 with abnormal tests before TPN, the mean SGPT value rose from 45 to 102 IU per liter (p less than 0.05). Liver biopsies performed in four @entity1 with substantial elevations of aminotransferases revealed only minor nonspecific changes and no @entity1560 . Elevated liver function tests promptly returned to baseline after TPN was discontinued, and progressive @entity409 was not observed in any @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)
