Bilateral salpingectomy can reduce the risk of XXXX in the general population: A meta-analysis.

@entity43 @entity1 @entity5274 @entity1621
BACKGROUND: The results of recent studies have suggested that high-grade serous @entity43  predominantly arises within the fallopian tubes. The @entity43 ( @entity43 ) risk in @entity1 with a history of @entity1621 ( @entity1621 ) has been reported. We performed a meta-analysis to determine the impact of @entity1621 in preventing @entity43 in the general population. METHODS: We searched the PubMed, MEDLINE, and EMBASE databases and CENTRAL in the Cochrane Library for all English-language articles published up to January 2015, using the key @entity43 ' and ' @entity1621 .' Odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated by standard meta-analysis techniques. RESULTS: Of the 77 studies retrieved, three were included in this meta-analysis, including one cohort study and two population-based case-control studies with 3509 @entity1 who underwent @entity1621 and 5,655,702 controls who did not undergo salpingectomy. Over the combined study period, 29 of the 3509 @entity1621 @entity1 developed @entity43 compared with 44,006 of the 5,655,702 without salpingectomy. The meta-analysis results based on the fixed effects model revealed a significant decrease in the risk of @entity43 occurrence in the @entity1 who underwent @entity1621 relative to the controls (OR=0.51, 95% CI 0.35-0.75, I(2)=0%). This pattern was also observed in subgroup analysis for the study type. CONCLUSIONS: Our results suggest that @entity5274 is an effective measure to reduce @entity43 risk in the general population. Therefore, prophylactic @entity1621 should be considered for @entity1 who require hysterectomy with benign indications or sterilisation procedures.
