Extracorporeal photochemotherapy for the treatment of XXXX .

@entity1 @entity2132 @entity792
Photopheresis (extracorporeal photochemotherapy, ECP) is a new type of photochemotherapy used for the treatment of oncological and @entity792 . Additionally, recent reports indicate that this therapy is promising in both pediatric and adult @entity1 who develop @entity2132 ( @entity2132 ) resistant to conventional protocols after bone marrow transplantation (BMT). In this paper, we review 31 studies where ECP was used in the treatment of acute and chronic @entity2132 . A total of 76 (32% female) acute @entity2132 @entity1 have been considered in 11 series. Fifty-nine @entity1 presented with skin involvement; 47 had liver involvement, and 28 had gastrointestinal manifestations. Treatment duration ranged from 1 to 24 months. A regression of skin manifestations was observed in 83% of the @entity1 with a complete response in 67%. A complete regression of liver and gut manifestations was reported in 38% and 54% of the @entity1 , respectively. The overall @entity1 survival was 53%. Of the 43 @entity1 alive, 8 developed chronic @entity2132 manifestations. The immunosuppressive therapy was discontinued in 28% of cases and reduced in 46%. A total of 204 (45% female) chronic @entity2132 @entity1 treated with ECP 1 to 110 months from transplantation have been considered in 20 series. One hundred twenty-eight @entity1 presented with skin involvement, 84 with liver, 31 with lung, and 59 with oral manifestations. Treatment duration ranged from 3 to 40 months. A regression of skin manifestations was observed in 76% of @entity1 with a complete response in 38%. An improvement of liver and lung involvement was reported in 48% and 39% of the @entity1 , respectively. Of the 59 @entity1 with oral manifestations, an improvement was obtained in 63% of cases. The overall @entity1 survival was 79%. ECP is a nonaggressive treatment that may benefit @entity1 with both acute and chronic @entity2132 who do not respond to standard immunosuppressive therapy.
