Increased expression of @entity8923 in the serum and islets of type 1 XXXX .

@entity1 @entity6 @entity10454 @entity102 @entity1723 @entity8923 @entity21264
@entity1723 ( @entity1723 ) is a @entity102 characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed @entity8923 levels in the plasma of juveniles with @entity1723 . Compared to control subjects, @entity8923 levels were significantly elevated in @entity1 with @entity1723 . On the other hand, levels of @entity10454 ( @entity10454 ) and @entity21264 , two negative regulators of @entity8923 function, remained unchanged when comparing @entity1723 to control samples. Notably, however, although @entity10454 levels were not elevated, @entity8923 and @entity10454 were found to be positively correlated in type 1 @entity6 . Even so, free, unbound @entity8923 remained significantly increased in @entity6 @entity1 . Additionally, correlation studies also revealed that @entity8923 and @entity10454 are positively correlated with HbA1c levels in @entity1723 @entity1 , suggesting a potential link between @entity8923 and metabolic control in these @entity1 . Finally, we observed a significant increase in @entity8923 protein expression within @entity1 pancreatic islet specimens collected from type 1 @entity6 . These results further expand our knowledge of the role of @entity8923 in @entity1723 , may give insight into common pathogenic mechanisms associated with metabolic control in both @entity1723 and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for @entity1723 @entity1 .
