Experimental XXXX arterial @entity715 formation and thrombolysis: a fiberoptic study.

@entity235 @entity715 @entity850
We produced arterial thrombi that simulated the clinical condition in @entity235 iliac arteries by endothelial denudation and partial occlusion. The processes of @entity715 formation and thrombolysis were examined by vascular fiberscope. Laminar mural thrombi developed in all 21 preparations 10 minutes after blood reperfusion, with @entity850 formation. Over 50% luminal obstruction with thrombi occurred in 10 preparations 30 minutes after inducing @entity850 . Total occlusion with thrombi occurred in four preparation (31%) at 1 hour, and in all nine at 3 hours after inducing @entity850 . Usually, red @entity715 at the denudated region grew in size distal to the sited of @entity850 . Histologically, thrombi of less than 1 hour duration consisted of a loose fibrin network and those of over 3 hours' duration consisted of a dense fibrin network. Infusion of 144,000 IU of urokinase (UK) reduced the size of thrombi less than 1 hour old during fiberoptic observation. However, UK infusion of similar dose failed to recanalize two of four preparations with 3-hour-old thrombi. In conclusion, arterial thrombi that closely simulate those observed clinically can be made by endothelial denudation and partial occlusion, and the vascular fiberscope provides a useful method for analysis of @entity715 and thrombolysis.
