Effect of XXXX inhibition on the gastric volume: assessed by magnetic resonance imaging.

@entity7080 @entity1537 @entity354
BACKGROUND: @entity7080 inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for @entity354 by decreasing acid secretion. AIM: To determine the effect of PPI therapy on the gastric volume after a standard meal. METHODS: A total of nine healthy subjects were studied using magnetic resonance imaging, before and after a standard liquid meal mixed with a paramagnetic contrast to help demarcate the gastric region. Images were acquired for a total of 90 min after the meal. Studies were conducted before and following @entity1537 twice daily for 7 days. Images were analysed to determine the gastric liquid volume. RESULTS: Gastric volume, 15 min after the meal peaked to 611 +/- 37 mL on the control day and 539 +/- 30 mL following the PPI administration (P < 0.001). Average gastric volume remained significantly lower (56 +/- 9 mL, P < 0.05) on the PPI therapy from 5 to 75 min after the meal. CONCLUSIONS: @entity7080 inhibitor therapy causes a significant reduction in the gastric contents volume during first 75 min after the meal. In addition to increasing the gastric pH, PPI therapy may decrease the frequency of @entity354 by decreasing the volume of gastric contents.
