Association of Fc gamma-receptors IIa, IIIa, and IIIb genetic polymorphism with susceptibility to XXXX in South Indian population.

@entity1 @entity3141 @entity2521 @entity7278
BACKGROUND AND OBJECTIVE: Fc gamma receptors (FcyRs) are the members of the immunoglobulin superfamily and may play a role in the pathogenesis of @entity2521 . Genetic variation in these receptors and its link with various forms of @entity2521 is being studied in different populations. The aim of the present study is to determine whether specific FcyRIIa, FcyRIIIa, and FcyRIIIb alleles and/or genotypes are associated with risk for susceptibility to generalized @entity7278 (GCP) in South Indian population. MATERIALS AND METHODS: The study population consisted of 120 South Indian subjects; 60 with GCP and 60 periodontally healthy. @entity3141 ( @entity3141 ) was extracted from samples collected by scrapping buccal epithelium. FcyRIIa and FcyRIIIa genotyping were performed by polymerase chain reaction (PCR) amplification of @entity3141 with allele-specific primers followed by allele-specific restriction digestion of the products. However, FcyRIIIb genotyping was done by allele-specific PCR. RESULTS: No significant difference in the distribution of FcyRIIa H/R and FcyRIIIa NA1/NA2 genotypes or their respective alleles was observed in GCP @entity1 and healthy subjects. For FcyRIIIa F/V genetic polymorphism, the homozygous V/V genotype and V allele were significantly overrepresented in GCP @entity1 while F/F genotype and F allele in controls. CONCLUSION: The present study demonstrates that FcyRIIIa V/V genotype, as well as V allele, could be a possible risk factor for @entity7278 in South Indian population.
