Experimental hyperlipidemia induces insulin resistance in XXXX .

@entity844 @entity742 @entity1133 @entity4322 @entity412 @entity701 @entity1460 @entity1011 @entity6679 @entity413 @entity165
This study aimed to evaluate the effects of intravenous infusion of a @entity1460 -based lipid emulsion on some blood energy-related metabolites and insulin sensitivity indexes in @entity742 . Four clinically healthy ewes were assigned into a 2-treatment, 2-period cross-over design. Either normal saline (NS) or lipid emulsion (LE) was intravenously introduced at a rate of 0.025  mL  kg(-1)  min(-1) for 6  h. The concentrations of blood nonesterified @entity844 (NEFA), @entity4322 , @entity412 , @entity165 , @entity1133 , @entity1011 , @entity701 , @entity413 , and insulin were measured at different time points. After 6  h, intravenous @entity413 tolerance test was performed. Lipid infusion elicited an increase (P < 0.05) in the NEFA, @entity4322 , and @entity412 concentrations compared with the baseline value and NS infusion. Infusion of NS did not influence blood @entity413 concentration; however, LE infusion increased plasma @entity413 concentration (P < 0.05). At time point 12  h, serum insulin concentrations were increased (P < 0.05) in NS treatment; however, such an increase was not observed in the LE treatment. Insulin sensitivity index for the LE infusion was lower (P < 0.05) than that for the NS treatment. The @entity413 effectiveness was not (P > 0.05) different among treatments. In the LE treatment, acute-phase insulin responses increased (P < 0.05) and disposition index decreased (P < 0.001) compared with NS treatment. The results showed that experimentally induced NEFA in blood could cause insulin resistance in @entity742 . The current model could be used to evaluate the pathogenesis of conditions associated with @entity6679 and insulin resistance.
