Correlation of B type natriuretic peptides with clinical and echocardiographic parameters in heterogeneous population of XXXX with symptoms suggestive of heart failure.

@entity1 @entity340 @entity3876 @entity1011
PURPOSE: NT-proBNP and @entity3876 concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and @entity3876 in heterogeneous group of CHF @entity1 on the basis of these peptides' correlation with NYHA class, LVEF and WMI measured by echocardiography. MATERIAL AND METHODS: Consecutive @entity1 admitted for suspected of CHE Blood samples were drawn for NT-proBNP, @entity3876 , @entity1011 and echocardiography was performed. RESULTS: 71 @entity1 were included. CHF was diagnosed in 53. Sensitivity of NT-proBNP and @entity3876 in diagnosing CHF was 83% and 94% respectively (P = 0.079). Levels of both peptides correlated equally well with NYHA class (R = 0.537, p < 0.001; R = 0.473, P < 0.001), LVEF (R = -0.623, p < 0.001; R = -0.601, P < 0.001) and WMI (R = 0.590, P < 0.001; R = 0.527, P = 0.001). @entity1011 correlated with both peptides, age correlated with NT-proBNP. No difference between sexes was found in both peptides' concentrations. In multivariate analysis independent determinants of @entity3876 were LVEF, presence of @entity340 and NYHA class. In case of NT-proBNP age and @entity1011 also displayed independent influence. CONCLUSIONS: NT-proBNP and @entity3876 show good sensitivity in detecting CHE Levels of both peptides correlate equally well with clinical and echocardiographic parameters of CHF, which makes them equally adequate in biochemical staging of CHF's severity regardless of its underlying cause. Levels of natriutretic peptides reflect contractile dysfunction, @entity340 and clinical condition. Age and @entity1011 concentration but not @entity1 ' sex should additionally be considered when measuring NT-proBNP.
