Evaluation of residual tissues after adjuvant therapy in germ cell XXXX .

@entity1 @entity41 @entity2971 @entity5 @entity7468 @entity44 @entity979 @entity39 @entity900 @entity730 @entity1758 @entity3438
OBJECTIVE: Germ cell @entity5 are the @entity5 sensitive for adjuvant therapy such as radiotherapy and chemotherapy. We evaluated the pathological findings of these @entity5 to determine the persistence of residual viable @entity5 cells after adjuvant therapy. @entity1 AND METHODS: Between 1988 and 2005, we treated 31 @entity1 with @entity3438 with @entity7468 ( @entity7468 ) and 15 @entity1 with non-germinomatous @entity2971 (NGMGCTs). All 46 @entity1 received a combination of chemo- and radiotherapy. A second-look operation was performed in 3 of 31 @entity1 with @entity3438 or @entity3438 with @entity7468 and 12 of 15 @entity1 with NGMGCTs. The follow-up period was 2-139 months (median 95) in @entity1 with @entity3438 or @entity3438 with @entity7468 (group 1) and 10-202 months (median 65) in NGMGCT @entity1 (group 2). RESULTS: Post-treatment, 3 group 1 and 12 group 2 @entity1 manifested @entity41 . The pathological diagnosis in group 1 @entity1 was @entity44 , @entity979 , and fibrous tissue with @entity730 ; in group 2 it was yolk @entity5 (n = 1), immature @entity44 (n = 3), @entity44 (n = 4), and @entity39 or fibrous tissue (n = 4). While no group 1 @entity1 manifested @entity5 cells, @entity1758 -positive viable @entity5 cells were present in resected tissues from one-third of the group 2 @entity1 (3 immature teratomas and 1 yolk @entity5 ). CONCLUSION: The absence of viable @entity5 cells in residual tissue indicates that the combination of @entity900 -based chemo- and radiotherapy was effective in our @entity3438 @entity1 . On the other hand, in @entity1 with NGMGCTs, these cells persisted despite this combination therapy.
