@entity4349 induced XXXX . An analysis of 16 autopsy cases.

@entity32 @entity296 @entity712 @entity82 @entity39 @entity4349 @entity194 @entity2118 @entity1370
The hearts of 16 autopsy cases with a past history of administration of @entity4349 antitumor drugs (DNR, ADR and ACM) and a sign of @entity712 were investigated morphologically. In macroscopic observation, both ventricles were more or less dilated with thinning of the ventricular wall. Mural thrombi were recognized in the left ventricle of 2 cases. Histologically, the @entity296 could be roughly classified into two groups, a) myocardial changes in cases with rapidly developed @entity712 (acute form), and b) myocardial changes in cases with relatively slowly developed @entity712 . In acute form, myocardial cells showed marked swelling with dilatation of central sarcoplasmic core, marked reduction of myofibrils, vacuolization of cytoplasm and enlargement of nucleus accompanied by distinct large nucleolus. @entity296 were scattered among these degenerative cells. These degenerative and @entity39 cells were distributed diffusely in both ventricular walls, but were more frequent in the left ventricular wall than in the right one. @entity32 was also recognized not only in the myocardium, but also in the endocardium and epicardium. In chronic form, on the other hand, @entity194 and attenuation of myocardial cells with a hypereosinophilic change of the cytoplasm and an increase in number of @entity2118 , and marked reduction of myocardial cells were most common findings. These changes of chronic form, however, could not be identified as the specific changes of @entity4349 @entity1370 . @entity82 was hardly seen in the myocardium of both acute and chronic forms.
