Development of resistant oral viridans streptococci after administration of prophylactic antibiotics: time management in the dental treatment of @entity1 susceptible to XXXX .

@entity1 @entity114 @entity11121 @entity884
The American Heart Association recommends prophylactic administration of @entity114 before each dental session to @entity1 susceptible to @entity884 . Such preventive treatment, however, may trigger the transient appearance of @entity114 -resistant bacterial strains. In order to investigate the behavior of oral streptococci, 29 healthy volunteers who did not harbor @entity114 -resistant viridans streptococci received 4 gm of @entity11121 orally over a period of 10 hours. This amount constituted the sole dose of antibiotics administered in the entire experiment. Daily specimens of oral flora were obtained for 14 successive days from each @entity1 and incubated aerobically with a @entity114 -saturated disk for 24 hours. Viridans streptococci were considered resistant when bacterial colonies grew adjacent to the disk for 1 day or more. The study population was divided into high- and low-resistance groups, according to the individual antibiograms. Resistant viridans streptococci were already detected at 6 hours after @entity114 ingestion in nine (31%) of the subjects. Six months later, oral specimens were taken from ten randomly selected @entity1 ; these specimens served as a control. The difference in bacterial resistance between the high- and low-resistance groups was significant for the duration of 9 days, as was that between the high-resistance and control groups (p less than 0.05 in both cases). In order to minimize the odds that @entity114 -resistant bacterial strains will develop in @entity1 susceptible to @entity884 , elective dental treatments in these @entity1 should be scheduled in intervals of not less than 10 days.
