Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in XXXX Individuals.

@entity1 @entity753 @entity1007 @entity412 @entity9206 @entity65 @entity165
INTRODUCTION: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum @entity165 . OBJECTIVE: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies. METHODS: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed. RESULTS: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No @entity1 had received any @entity165 -lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total @entity165 (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein @entity165 (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein @entity165 and @entity412 levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (>4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term ( <=4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly @entity753 than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the @entity9206 reduced TC and LDL-C levels to a greater extent than other bacterial strains. CONCLUSIONS: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of @entity1007 and may lead to reductions in risk factors for @entity65 .
