Bronchial lavage P(16INK4A)gene promoter methylation and XXXX diagnosis: A meta-analysis.

@entity2 @entity986
OBJECTIVE: To evaluate the diagnostic value of bronchial lavage @entity986 promoter methylation and @entity2 . MATERIALS AND METHODS: The databases of PubMed, Medline, China National Knowledge Infrastructure, and Wanfang were electronically searched by two reviewers to find the suitable studies related to the association between @entity986 Apromoter methylation and @entity2 . The @entity986 Apromoter methylation rate was extracted from each included individual study. The diagnostic sensitivity, specificity, and area under the receiver operating characteristic ROC curve of bronchial lavage @entity986 Aas a biomarker for diagnosis of @entity2 were pooled by stata11.0 software (Stata Corporation, College Station, TX, USA). RESULTS: At last, 10 publications were included in this meta-analysis. Of the included 10 studies, five are published in English with relatively high quality and other five papers published in Chinese have relatively low quality. The pooled sensitivity and specificity of bronchial lavage @entity986 Apromoter methylation for @entity2 diagnosis were 0.61 (95% confidence interval [CI]: 0.57-0.65) and 0.81 (95% CI: 0.78-0.85), respectively, with random effect model. The ROC curve were calculated and drawn according to Bayes' theorem by stata11.0 software. The systematic area under the ROC was 0.72 (95% CI: 0.68-0.76), which indicated that the diagnostic value of bronchial lavage @entity986 Apromoter methylation for @entity2 was relatively high. Moreover, no significant publication bias was existed in this meta-analysis (t = 0.69, P > 0.05). CONCLUSION: Bronchial lavage @entity986 promoter methylation can be a potential biomarker for diagnosis of @entity2 .
