Genetic polymorphisms of the XXXX in a Greek population and their relation to plasma lipid and lipoprotein levels.

@entity1 @entity412 @entity15783
@entity15783 is a protein component of @entity412 -rich lipoproteins and high-density lipoproteins (HDL). In this study, two common genetic polymorphisms of the @entity15783 gene [codons 347(allele A and T) and 360 (allele 1 and 2)] were investigated in Greek @entity1 with hyperlipidaemia and in healthy individuals matched for age, sex and smoking habits. In both study populations we evaluated the effect of these polymorphic sites on lipid and lipoprotein plasma levels and the body mass index (BMI). The frequencies of the 1/1 and 1/2 genotypes in codon 360 were 0.94 and 0.06 in hyperlipidemic @entity1 and 0.92 and 0.08 in the control population, respectively. The frequencies of the A/A, A/T and T/T genotypes in codon 347 were 0.62, 0.34 and 0.04 in hyperlipidemic @entity1 and 0.59, 0.33 and 0.08 in the control population, respectively. None of the above genotype frequency differences between the study populations reached statistical significance. The control population was not affected by any polymorphism of the @entity15783 gene. Hyperlipidaemic @entity1 , carriers of the allele 2 (1/2 genotype), had significantly lower plasma @entity412 levels than carriers of the allele 1 (p = 0.03). Genetic variation in codon 347 had no influence on lipid and lipoprotein plasma levels. None of the polymorphisms at codons 360 and 347 affected the BMI. In conclusion, this study describes for the first time the genotype frequencies for polymorphic sites in codons 360 and 347 of the @entity15783 gene in a Greek population and suggests that the presence of the allele 2 is associated with lower plasma @entity412 levels in hyperlipidaemic @entity1 .
