Expression of XXXX by Reed-Sternberg cells defines a major subtype of classical @entity978 with frequent infiltration of eosinophils and/or plasma cells.

@entity23427 @entity24101 @entity23055 @entity25062 @entity14421 @entity17469 @entity6332 @entity14420 @entity14700 @entity978
Classical @entity978 ( @entity978 ) is characterized by rare neoplastic Hodgkin and Reed-Sternberg (H-RS) cells within abundant reactive cellular backgrounds. In most cases, H-RS cells originate from the B-cell lineage, but their immunophenotypes are unusual. Here we newly found frequent expression of chemokine receptors @entity24101 and @entity23055 and their respective ligands @entity6332 and @entity17469 in @entity978 -derived cell lines. @entity23055 is known to be selectively expressed by plasma cells, whereas @entity17469 attracts eosinophils via @entity23427 and plasma cells via @entity23055 and @entity23427 . Therefore, we examined their expression in @entity978 tissues by immunohistochemistry. We found that H-RS cells in 15 of 19 cases were positive for @entity17469 . Among them, seven cases were also positive for @entity23055 , suggesting a potential autocrine effect. In situ hybridization confirmed the expression of @entity17469 mRNA in H-RS cells. The @entity17469 positivity in H-RS cells did not significantly correlate with that of @entity25062 , @entity14420 , @entity14421 , or @entity14700 . However, it significantly correlated with the background accumulation of eosinophils, plasma cells, and @entity23055 + cells. Thus, the production of @entity17469 by H-RS cells may play a major role in tissue accumulation of eosinophils and/or plasma cells in classical @entity978 . The frequent expression of @entity23055 in H-RS cells themselves also supports their close relationship to plasma cells.
