Exposure to activity-based XXXX impairs contextual learning in weight-restored @entity35 without affecting spatial learning, taste, @entity148 , or dietary-fat preference.

@entity1 @entity448 @entity1278 @entity969 @entity148 @entity4807 @entity35 @entity2798
UNASSIGNED: Relapse rates are high amongst @entity1278 ( @entity1278 ) suggesting that some alterations induced by @entity1278 may remain after weight restoration. OBJECTIVE: To study the consequences of @entity1278 without confounds of environmental variability, a rodent model of activity-based @entity448 (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and @entity148 -like behavior after weight restoration. METHODS: To test this hypothesis, we exposed adolescent female @entity35 to ABA (1.5 h food access, combined with @entity2798 ) and compared their behavior to that of control @entity35 after weight restoration was achieved. The @entity35 were tested for learning/memory, @entity148 , food preference, and taste in a set of behavioral tests performed during the light period. RESULTS: Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to @entity969 nor @entity4807 (described by @entity1 as "sweet" and "bitter," respectively). Nor Do we find alterations in @entity148 -like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat is not altered. DISCUSSION: Overall, our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, @entity148 , or fat preference.    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:169-181).
