Identification of XXXX in Mild @entity131 Using an Index of Quantitative Brain Electrical Activity.

@entity1 @entity1545 @entity131 @entity341 @entity542 @entity1410 @entity2075
Abstract Rapid identification of @entity2075 following closed @entity542 represents a significant health care need because of the potentially life-threatening risk they present. This study demonstrates the clinical utility of an index of brain electrical activity used to identify intracranial @entity1410 in @entity131 ( @entity131 ) presenting to the @entity341 ( @entity341 ). Brain electrical activity was recorded from a limited montage located on the forehead of 394 closed head injured @entity1 who were referred for CT scans as part of their standard @entity341 assessment. A total of 116 of these @entity1 were found to be CT positive (CT+), of which 46 @entity1 with @entity2075 (CT+) were identified for study. A total of 278 @entity1 were found to be CT negative (CT-) and were used as controls. CT scans were subjected to quanitative measurements of volume of blood and distance of bleed from recording electrodes by blinded independent experts, implementing a validated method for @entity1410 measurement. Using an algorithm based on brain electrical activity developed on a large independent cohort of @entity131 @entity1 and controls ( @entity131 -Index), @entity1 were classified as either positive or negative for structural @entity1545 . Sensitivity to @entity1410 was found to be 95.7% (95% CI=85.2, 99.5), specificity was 43.9% (95% CI=38.0, 49.9). There was no significant relationship between the @entity131 -Index and distance of the bleed from recording sites (F=0.044, p=0.833), or volume of blood measured F=0.179, p=0.674). Results of this study are a validation and extension of previously published retrospective findings in an independent population, and provide evidence that a @entity131 -Index for structural @entity1545 is a highly sensitive measure for the detection of potentially life-threatening @entity2075 , and could contribute to the rapid, quantitative evaluation and treatment of such @entity1 .
