Topical XXXX delays healing of deep thermal wounds in albino @entity95 .

@entity75 @entity1066 @entity95 @entity6478 @entity4490
The present investigation was undertaken to explore the @entity1066 healing properties of three dosage schedules of different strengths of topically administered @entity6478 solution in thermally produced skin @entity1066 on the side of the midline on the back of the @entity95 . Four circular thermal burns about 4.0 cm in diameter (two on either side of the midline) were made 4.0 cm apart on the pre shaved back of each anaesthetized (with @entity4490 sod., 45 mg/kg, ip) @entity95 with a heated template, applied for 30 sec. Three days later under anaesthesia, the burns were excised removing epidermis, dermis and subcutaneous tissue. The animals were randomly divided into various groups. @entity1066 on one side of the midline were treated with normal saline and served as control, whereas those on the other side were treated with @entity6478 solutions. Each @entity1066 was observed for its size, slough formation and any sign of irritation on alternate days until healing was complete. Healing of @entity1066 were significantly delay in comparison to control group with all the strength of @entity6478 (0.02%, 0.5% and 1%) in all the dosage schedule (o.d., b.i.d. and q.i.d.) in terms of days required for complete healing (except with b.i.d. dosage schedule of 0.5% _ q.i.d. dosage schedule of 1% @entity6478 solution), @entity1066 size and area under the size time curve (except with b.i.d. _q.i.d. dosage schedule of 1% @entity6478 solution). Thus, it is concluded that unlike mechanical @entity1066 topical @entity6478 delays wound repair in @entity75 .
