@entity5 of the XXXX and prostate: immunohistochemical, ultrastructural, and DNA flow cytometric analyses of nine cases.

@entity1 @entity2283 @entity242 @entity1494 @entity5 @entity75 @entity39 @entity189 @entity4483 @entity2277
@entity5 of the genitourinary tract is a rare pathologic entity of hitherto unknown etiology that, because of the cellular pleomorphism and the infiltrative nature of the lesion, may be mistakenly diagnosed as @entity189 or @entity242 . We retrospectively studied nine pseudosarcomatous @entity5 involving the bladder and prostate to define characteristic parameters that may allow for accurate diagnosis. The study @entity1 included four @entity1 and five @entity1 with a mean age of 48.7 years. Histologic analysis revealed @entity75 with a proliferation of spindle fibroblastic cells in a background of granulation tissue-type vascularity and inflammatory cells. Mitoses were infrequent and no atypical forms were found. Immunostaining was positive for @entity2277 and smooth muscle actin, and negative for @entity4483 protein, @entity2283 , myoglobin, and keratin. Ultrastructurally, the lesion displayed fibroblastic and myofibroblastic cell features. Flow cytometric DNA content analysis revealed uniform DNA diploidy and a low S-phase fraction. All @entity1 were alive and well with no evidence of disease after a mean follow-up of 4.8 years. In contrast, the @entity189 and @entity242 of the @entity1494 and prostate that were used as controls occurred in older @entity1 and had more frequent mitoses with atypical forms, @entity39 , and different immunostaining profiles; they were preponderantly aneuploid or diploid with high S-phase fraction. Awareness of the clinicopathologic and biologic characteristics of these lesions is necessary to ensure their accurate diagnosis and to prevent unnecessary radical therapy.
