The role of an abnormal @entity1486 level and an abnormal digital rectal examination in the diagnosis of XXXX : A cross-sectional study in Qatar.

@entity1 @entity263 @entity1069 @entity5 @entity1067 @entity1486
OBJECTIVE: To investigate the role of an abnormal @entity1486 (PSA) level and abnormal findings on a digital rectal examination (DRE) in the detection of @entity263 in @entity1 in Qatar. @entity1 AND METHODS: Between June 2008 and September 2012, 651 @entity1 had a transrectal ultrasonography-guided biopsy of the prostate (TRUSBP) at our centre. The indications for a biopsy were a high PSA level (>4  ng/mL), or an abnormal DRE result. @entity1 were assessed by a thorough history, clinical examination and routine laboratory investigations. Data, including age, DRE findings, TRUS findings, total PSA level, prostate volume and the pathology results, were evaluated. RESULTS: The mean (SD) age of the 651 @entity1 was 64.1 (7.4) years. @entity263 was detected in 181 @entity1 (27.8%), @entity1067 in 275 (42.2%) and @entity1069 in 236 (36.4%). The sensitivity and specificity for detecting @entity263 were 93.9% and 8.5% for an abnormal PSA level (>4  ng/mL), 46.1% and 84.7% for abnormal DRE findings, and 95% and 30.2% for the two combined. Using a receiver operating characteristics curve, a PSA threshold of 7.9  ng/mL had a sensitivity of 56.6% and specificity of 52.8%. When a PSA threshold of 7.9  ng/mL was used in combination with abnormal DRE findings, the overall accuracy was 76.9%. CONCLUSION: The PSA threshold level of 7.9  ng/mL, determined by this analysis, has a higher likelihood of detecting @entity263 in @entity1 in Qatar. However, it failed to detect @entity5 in substantially many @entity1 with statistically significant disease.
