Antinociceptive activity and toxicity of XXXX and @entity37181 in @entity19 .

@entity4485 @entity410 @entity19 @entity27026 @entity1337 @entity1510 @entity6882 @entity1576 @entity37181 @entity1286
The antinociceptive (radiant heat tail-flick), convulsant and lethal activities of @entity6882 ( @entity27026 ) and @entity37181 (NMEP) were studied after s.c. and i.c.v. administration to @entity19 . Both compounds s.c. exhibited @entity1510 -reversible antinociceptive activity. MEP (ED50 = 23 mg/kg) was 2.5 to 5 times more potent, on a molar basis, than NMEP (ED50 = 72 mg/kg). NMEP was a convulsant [ED50 = 105 mg/kg (s.c.) and 64 micrograms/ @entity19 (i.c.v.)], with a small therapeutic index relative to @entity1337 whose activity was potentiated by @entity1510 and antagonized by @entity4485 or @entity1286 , s.c. Death due to s.c. MEP was preceded by @entity410 , whereas i.c.v. MEP provoked a primarily depressant lethality. @entity1510 antagonized death due to i.c.v. MEP while unmasking its convulsant activity. It is concluded that NMEP is the principal mediator of MEPs central nervous system excitation, that @entity410 are mediated by a different population of receptors than either @entity1576 and that @entity1510 exacerbates the convulsant activity of MEP and NMEP.
