Impact of common XXXX allele on @entity1 cognitive functions.

@entity6344 @entity1 @entity101 @entity52655 @entity33612
The @entity33612 polymorphism ( @entity6344 substitution, intron 9) of the @entity52655 gene has recently been associated with episodic memory and cognitive flexibility. These findings were inconsistent across reports though, and largely lacked gene-gene or gene-environment interactions. The aim of the present study was to determine the impact of the @entity33612 polymorphism on clinically relevant cognitive domains and its interaction with the modifiers 'lifestyle' and 'cardiovascular risk factors'. Five-hundred forty-five elderly volunteers (mean age 64 years,   7 years, 56% @entity1 ) accomplished a comprehensive cognitive testing. Principal component analysis was used to reveal the internal structure of the data, rendering four composite scores: verbal memory, word fluency, executive function/psychomotor speed, and working memory. Lifestyle was assessed with a detailed questionnaire, age-associated risk factors by clinical interview and examination. There was no main effect of the @entity33612 genotype on any cognitive composite scores. However, we found worse performance in executive functions for T-allele carriers in the presence of arterial @entity101 (b=-0.365, p=0.0077 and 0.031 after Bonferroni correction). This association was further modified by gender, showing the strongest association in @entity101 females (b=-0.500, p=0.0072 and 0.029 after Bonferroni correction). The effect of @entity52655 on cognitive function seems to be complex and modified by gender and arterial @entity101 .
