Recombinant @entity1 XXXX and its effects on osseointegration.

@entity177 @entity1 @entity2533 @entity702
@entity177 are still a common occurrence, especially in areas of poor bone quality. The purpose of this study was to observe whether the application of a growth factor, recombinant @entity1 @entity2533 (rhTGF-beta1), would improve the healing of bone adjacent to @entity702 dental implants. Four adult male Yucatan minipigs had four @entity702 dental implants placed into the inferior border of each hemimandible. On the control side, the implants were placed in standard fashion. On the experimental side, rhTGF-beta1 within a carrier gel was placed into the recipient site before implant placement. After a 6-week healing period, two implants from each side were evaluated by pull-out testing and histomorphometric analysis. The mean pull-out force for experimental implants was 1,124.01 N and 818.12 N (P = 0.5015) for controls. The mean percentage of bone between adjacent threads on the implant surface was 49.74% for the experimental group and 36.50% for controls (P = 0.0783). The mean percentage of bone-implant surface contact was 41.86% for the experimental implant sites and 24.60% for the control implant sites (P = 0.0452). The application of rhTGF-beta1 to implant sites appears to increase the amount of bone healing adjacent to a @entity702 dental implants in minipig mandibles at the 6-week period. Further studies are required to quantify better the amount of growth factor required and to study its effects over a broader period of time to see whether these differences are maintained.
