Experimental XXXX to systemic drugs.

@entity19 @entity786 @entity2644 @entity9584 @entity5478 @entity5105 @entity56 @entity2169 @entity10040
We have induced @entity9584 in @entity19 to systemically administered drugs, specifically @entity10040 and @entity2644 . @entity19 were photosensitized to systemic @entity10040 or @entity2644 by i.p. administration of drug followed by UVB and UVA irradiation of shaved flank skin, on two consecutive days. Control @entity19 received i.p. drug with no irradiation. In some experiments @entity786 pretreatment, or intradermal Corynebacterium parvum ( @entity5478 ), was administered as an immunoadjuvant. All animals were photochallenged on day 5 with i.p. drug followed by UVA irradiation of one ear. @entity19 that had been previously immunized with drug and UV radiation developed @entity2169 and @entity5105 , evident 24 h after photochallenge, but not at 4 h. Control animals showed no reactions. In a typical experiment of photosensitization to systemic @entity10040 , the experimental group had a mean increase in ear thickness of 6.0 X 10(-2) mm 24 h after photochallenge, while unsensitized control animals showed a mean change of -0.8 X 10(-2) mm. The histopathology of the positive challenge reaction was characteristic of a @entity56 . Adoptive transfer of @entity9584 to systemic @entity10040 to naive recipients was accomplished by i.v. injection of lymph node cells (5 X 10(7) harvested from actively photosensitized donors. Clinical reports have suggested that exposure to systemic medications followed by sunlight can induce an eruption having a photoallergic basis. We now report the first experimental proof of that hypothesis. The @entity19 model should facilitate exploration of photoallergic mechanisms and, in addition, it provides the basis for a prospective test of systemic drugs for their photoallergenicity.
