Histopathological and immunohistochemical study of exocrine and endocrine XXXX in avian @entity683 A experimentally infected @entity233 showing evidence of pancreatic regeneration.

@entity788 @entity19352 @entity101 @entity233 @entity6 @entity656 @entity660 @entity1689 @entity281 @entity683 @entity209
In order to investigate the @entity660 caused by the @entity281 with either H7N1 or H7N3 low-pathogenicity avian @entity683 viruses, 28 experimentally infected @entity233 were submitted for histopathology, immunohistochemistry, haematobiochemistry and real-time reverse transcriptase polymerase chain reaction after different days post- @entity281 (DPI). The localization of viral antigen and the measurement of @entity19352 and glucagon expression in the pancreas were assessed to verify the progression from @entity788 to @entity209 , such as @entity6 . At the early @entity281 phase (4-7 DPI), a severe @entity656 was recognized. During the intermediate phase (8-17 DPI), a mixed acute/chronic change associated with regenerative ductular proliferation was observed. A loss of pancreatic islets was detected in most severe cases and viral antigen was found in the pancreas of 11/28 @entity233 (4-10 DPI) with the most severe histological damage. In @entity233 euthanized at 39 DPI (late phase), a @entity1689 was observed with the reestablishment of both the exocrine and the endocrine pancreas. @entity19352 and glucagon expression manifested a progressive decrease with subsequent ductular positivity. Haematobiochemistry revealed @entity101 in the first week post- @entity281 and hyperglycaemia in the second, with a progressive normalization within 21 DPI. This study allowed the identification of progressive @entity660 , suggesting that @entity683 virus might be responsible for metabolic derangements. Moreover, it highlighted a remarkable post-damage hyperplastic and reparative process from a presumptive common exocrine/endocrine precursor. This potential regeneration deserves further investigation for its relevance in a therapeutic perspective to replace lost and non-functional cells in @entity6 .
