Effect of food on gastrointestinal transit of liquids in XXXX .

@entity1 @entity5434 @entity1443 @entity3378 @entity27009
We investigated the gastrointestinal transit of liquids, as well as various gastric pH profiles, in fed @entity5434 . Twelve grams of a biscuit-type solid food were provided 1 h before the test. The @entity1443 method was used to determine the gastric half-emptying time (t(50%)), which provided an estimate of the gastric emptying rate. The gastric emptying rate of liquids was significantly reduced after food intake in monkeys. The mean t(50%) value was 143.5 min and comparable to that of @entity1 after eating. However, there was a large variability in the t(50%) between individual animals as shown by the coefficient of variance of approximately 80%. Next, the median oro-caecal transit time in fed monkeys was determined to be 1.8 h, using the @entity3378 - @entity27009 method. There was no significant difference in oro-caecal transit time between unfed and fed monkeys; thus, food intake has no significant effect on the oro-caecal transit time of liquids in either monkeys or @entity1 . However, the oro-caecal transit time in @entity1 is about 2 h longer than that in monkeys. Our experiments using several different foods suggested that the typical @entity1 gastric pH profile could not be simulated in fed monkeys.
