Impaired revascularization of transplanted XXXX pancreatic islets is chronic and glucose-independent.

@entity19 @entity6 @entity10835
BACKGROUND: Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in @entity19 islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets implanted into nondiabetic and @entity6 recipients, and also evaluated changes in vascular density up to 6 months posttransplantation. METHODS: Islets were syngenically transplanted beneath the renal capsule of normoglycemic or @entity10835 - @entity6 C57BL/6 @entity19 . One to 6 months later, the animals were killed and the grafts removed. Histologic slides were prepared and stained with Bandeiraea simplicifolia. RESULTS: The vascular density in all transplanted islets was decreased compared with native islets. There were no differences in the islet graft vascular density between nondiabetic and @entity6 animals. No improvement over time occurred. CONCLUSIONS: The vascular density is decreased in islets implanted to cure @entity6 recipients. No improvement occurs in transplanted islets after 1 month posttransplantation.
