Histological validation of diagnoses of XXXX among adults in the registries of Belarus and the Ukraine.

@entity5 @entity259 @entity189
In order to evaluate the diagnostic reliability of the @entity259 listed in adult registries from the Ukraine and Belarus, a histological review was organised of 327 randomly selected @entity259 cases diagnosed between 1980 and 1999. A final diagnosis was reached at a 5-day consensus conference by six pathologists who met around a multiheaded microscope. The study concluded with a comparison between the final diagnosis and the initial diagnosis. The pathologists agreed with the initial diagnosis of @entity5 in 286 cases (88%). A final diagnosis of papillary, follicular or @entity259 was reached in 86, 4, and 6% of the cases respectively. In 2.8% of the cases reviewed, diagnostic discrepancies persisted. The percentage of agreement between the final diagnosis and the initial diagnosis was 93%, with a weighted kappa-statistic of 0.61 (confidence interval 95% (CI(95%)): [0.45-0.77]). In all, 89% of the 286 confirmed @entity5 cases were in agreement for the type of @entity5 , with a kappa-statistic of 0.56 (CI(95%): [0.43-0.69]). The level of agreement differed according to @entity5 categories, with concordance rates of 94, 40 and 33% for papillary, follicular and medullary thyroid @entity189 respectively. The low prevalence of @entity259 in the adult population studied calls for further exploration. The discrepancies and classification difficulties encountered were analysed.
