@entity6 -induction @entity409 of 70-kDA dextran: role of XXXX and hypoinsulinemia.

@entity6 @entity409 @entity7964 @entity941 @entity35 @entity4854 @entity413
In vivo studies were conducted in @entity35 to determine the role of @entity4854 and hypoinsulinemia in the previously reported @entity409 and increase in the serum concentrations of 70-kDa @entity941 -dextran (FD-70) in @entity6 ( @entity6 ) rats. The serum, urine, and hepatic concentrations of FD-70 were measured by size exclusion chromatography after i.v. administration of a single doses (5 mg/kg) of FD-70. Intravenous administration of a single 2 IU/kg dose of insulin to @entity6 @entity35 at time zero or 4 h after the administration of FD-70 resulted in an increase in some and no change in other animals in their rate of elimination of FD-70 from serum. The presence or absence of a significant insulin effect on the disposition of FD-70 in these animals was, respectively, associated with the presence or absence of a significant insulin-induced hypoglycemic effect. Fasting @entity6 @entity35 for 24 h caused normoglycemia, and subsequently, the disposition of FD-70 became similar to that in @entity7964 ( @entity7964 ) @entity35 . Likewise, i.p. injections of @entity413 to @entity7964 @entity35 rendered them hyperglycemic, and the disposition of FD-70 in these @entity35 became similar to that in untreated @entity6 animals. However, i.v. injection of @entity413 , which did not result in sustained @entity4854 , did not change the disposition of FD-70 in @entity7964 @entity35 . Further, the disposition of FD-70 remained unaffected by an i.v. 2 IU/kg dose of insulin administered to @entity7964 @entity35 at time zero. Considering all animals, there was a significant negative relationship between the 12-h hepatic recovery of FD-70 and the area under the serum concentration-time curves of @entity413 . It is concluded that the @entity409 of FD-70 in @entity6 @entity35 is due to @entity4854 and not
