Pure XXXX and in situ component of ductal invasive carcinoma of the breast. A preliminary morphometric study.

@entity3821 @entity2372 @entity5 @entity146 @entity189 @entity6578
Nuclear pleomorphism is a fundamental feature in evaluating the @entity146 of @entity3821 ( @entity3821 ) of the breast. In this study, pure @entity3821 and the in situ component (IS-comp) of @entity189 ( @entity189 ) are compared in order to verify if these are two different entities or the same process observed at different times during its evolution. Five cases of pure @entity3821 and nine of @entity189 with extensive in situ component were selected. They were moderately and poorly differentiated. 30 nuclei for each @entity3821 , and 30 nuclei for both the in situ and invasive component of each @entity189 were studied; thus, a total of 720 nuclei were submitted to the @entity2372 ( @entity2372 ) analysis, which enables a numerical expression not only of dimensions (area, perimeter, diameter) but also of nuclear contour irregularities and nuclear shape distortions. Univariate statistical comparisons were carried out between the nuclei of: (1) @entity3821 and in situ component of @entity189 , (2) @entity3821 and the invasive component of infiltrating @entity189 and (3) between the in situ and invasive component of infiltrating @entity189 . Multivariate analysis was utilized to compare nuclei of @entity3821 with the in situ component of @entity189 . The in situ features of each @entity5 were also evaluated with the @entity6578 ( @entity6578 ). Nuclei of pure @entity3821 resulted significantly larger (p < 0.001) and with a more regular shape (p < 0.001) than those of the in situ component of @entity189 . No differences were observed between the nuclei of the in situ and the invasive component of infiltrating @entity189 . Multivariate statistical analysis discriminated 77% of nuclei of in situ proliferation when both G2 and G3 @entity5 were considered, and 80% when only G3 @entity5 were considered. In conclusions morphological differences exist between pure @entity3821 and the in situ component of @entity189 , which may be an expression of their biological behavior; moreover, these morphological differences seem to have a better discriminating power within the same histological grade.
