Birth weight, XXXX , and adult lung function.

@entity1 @entity3617 @entity55 @entity565 @entity1576 @entity1729
BACKGROUND: Historical cohort studies in England have found that @entity1729 in early childhood are associated with lower levels of lung function in late adult life. These relations are investigated in a similar study in Scotland. METHODS: In 1985-86 a follow up study was carried out of 1070 @entity1 who had been born in St Andrew's from 1921 to 1935 and followed from birth to 14 years of age by the Mackenzie Institute for Medical Research. Recorded information included birth weight and @entity1576 . The lung function of 239 of these individuals was measured. RESULTS: There was no association between birth weight and lung function. Pneumonia before two years of age was associated with a difference in mean forced expiratory volume in one second (FEV1) of -0.39 litres (95% confidence interval (CI) -0.67, -0.11; p = 0.007) and in mean forced vital capacity (FVC) of -0.60 litres (95% CI -0.92, -0.28; p < 0.001), after controlling for age, sex, height, smoking, type of spirometer, and other illnesses before two years. Similar reductions were seen in @entity1 and @entity1 . @entity3617 before two years was associated with smaller deficits in FEV1 and FVC. @entity565 or wheeze at two years and older and cough after five years were also associated with a reduction in FEV1. CONCLUSIONS: The relation between impaired fetal growth and lower lung function in late adult life seen in previous studies was not confirmed in this cohort. The deficits in FEV1 and FVC associated with @entity55 and @entity3617 in the first two years of life are consistent with a causal relation.
