Leber's XXXX II. @entity941 angiographic studies.

@entity1 @entity1781 @entity941
Fluorescein angiography was performed in 71 @entity1 at risk to develop Leber's @entity1781 (L.O.N.), in 10 females carriers of this disease and in 5 @entity1 during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 @entity1 could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same @entity941 angiographic abnormalities. One @entity1 from the at risk group who obtained high abnormal scores-identical to @entity1 in the acute phase-developed L.O.N. 6 months later.
