@entity11950 inhibits XXXX cell growth and migration via blocking @entity584 / @entity3470 / @entity4104 signaling.

@entity5 @entity4104 @entity19 @entity11950 @entity584 @entity3470 @entity1778 @entity98
@entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.
