Microinfarct pathology, XXXX , and cognitive systems.

@entity1 @entity303 @entity73 @entity1711 @entity1710 @entity1188 @entity195 @entity204
BACKGROUND AND PURPOSE: Little is known about the role of microinfarcts in @entity303 and cognition. We examined microinfarcts and @entity303 , @entity73 in community-dwelling older @entity1 . METHODS: Four hundred twenty-five subjects enrolled in the Religious Orders Study underwent annual clinical evaluations, including 19 neuropsychological tests and assessment for @entity303 , and brain autopsy (39% @entity1 ; mean age at @entity204 , 87; Mini-Mental State Examination score, 21). Neuropathologic examination documented the presence, number, and location of chronic microinfarcts on 6- m @entity1710 - @entity1711 -stained sections from cortical and subcortical regions. Multiple regression analyses adjusted for age at @entity204 , sex, education, @entity1188 , @entity195 pathology, and Lewy bodies. RESULTS: Microinfarcts were present in 129 of 425 (30%) @entity1 (54 cortical, 80 subcortical, 49 multiple); 58 of 129 (45%) of @entity1 with microinfarcts did not exhibit @entity1188 . @entity1 with microinfarcts had increased odds of @entity303 (OR, 1.77; 95% CI, 1.07-2.92), especially those @entity1 with multiple cortical microinfarcts. Microinfarcts were also associated with lower average global cognition (estimate, -0.287; SE, 0.113; P=0.012), particularly for @entity1 with multiple cortical microinfarcts. Microinfarcts were specifically associated with lower episodic memory (estimate, -0.279; SE, 0.138; P=0.044), semantic memory (estimate, -0.391; SE, 0.130; P=0.003), and perceptual speed (estimate, -0.400; SE, 0.117; P<0.001). In addition, single, multiple, and cortical microinfarcts were associated with worse semantic memory and perceptual speed (all P<0.028). Neither @entity1188 nor @entity195 pathology modified these associations (all P>0.154). CONCLUSIONS: Microinfarcts are common, and @entity1 with multiple cortical microinfarcts have higher odds of @entity303 . Microinfarcts are also associated with lower cognition, specifically perceptual speed and semantic and episodic memory.
