The Longitudinal Course of Fatigue in @entity309 : Results from the Norfolk XXXX Register.

@entity1 @entity1295 @entity309 @entity625
OBJECTIVE: Fatigue is common and burdensome in @entity309 ( @entity309 ). Despite @entity309 @entity1295 progression varying significantly between individuals in practice, existing longitudinal analyses only examine symptom advancement on a population level. This study aimed to determine @entity1295 trajectories at an individual level and to characterize those @entity1 with the poorest prognosis, with a view to enabling earlier interventions. METHODS: @entity1 with @entity309 reporting clinically relevant baseline @entity1295 (>=  20 mm on a 0-100 mm visual analog scale) were identified from a longterm inflammatory @entity625 cohort (the Norfolk @entity625 Register). Fatigue changes from baseline to 1- and 4-year followups were calculated, and sex-stratified group-based trajectory modeling (GBTM) determined trajectories of the symptom between which baseline characteristics were compared. RESULTS: Among 338 @entity1 , only minimal average changes were observed between recruitment to 1 year (6.0 mm, SD 26.9) and 4 years (5.5 mm, SD 29.3). This was despite 45.6% and 40.7% of @entity1 reporting clinically significant improvements (>=  10 mm) at these respective followups. GBTM revealed varied trajectories of @entity1295 , which for both sexes consisted of Improved ( @entity1 , n = 48 and @entity1 , n = 81) or persistent Moderate-high paths (n = 54, n = 105), and further included a persistent High trajectory in @entity1 (n = 50). @entity1 who followed persistent trajectories were best distinguished from improvers by @entity1 -reported rather than demographic or clinical variables. CONCLUSION: Among @entity1 with @entity309 presenting with clinically relevant @entity1295 , distinct longitudinal symptom trajectories were identified on an individual level despite nominal average changes in @entity1295 on a group level. It is possible to identify and characterize subgroups of @entity1 who report persistent @entity1295 and should therefore be targeted to receive future @entity1295 -alleviating interventions.
