Neuroendocrine XXXX - diagnosis circumstances, staging and treatment: a case report.

@entity1 @entity788 @entity1353 @entity5 @entity55 @entity158 @entity382 @entity3
UNASSIGNED: @entity5 ( @entity5 ) of the pancreas are rare and frequently malignant. Our presentation of a pancreatic NEN analyzes the diagnosis circumstances, staging, treatment, one-year evolution and disease particularities. A 39-year-old nonsmoker @entity1 was admitted in the Clinic of Pulmonology, Tirgu Mures, Romania with a @entity55 suspicion (fever, @entity158 irradiated below the diaphragm, mild @entity1353 ). The chest X-ray showed a rise of the left diaphragm. Abdominal ultrasound revealed a large pancreas-related @entity5 . Computerized tomography (CT) scan with contrast confirmed a well-vascularized @entity788 , which invades spleen, collateral circulation of the @entity382 without secondary lesions and no retroperitoneal adenopathies. The @entity1 was referred to the surgery where there was performed total @entity5 resection, spleen resection, and large lymphadenectomy. Histopathology and immunohistochemistry revealed the pancreatic NEN G2 grade, T3N1M0 and allowed accurate treatment. 2010 World Health Organization (WHO) @entity5 classification recommends further treatment-related biomarkers determination only in selected cases. Our case evolution after one year was favorable without local @entity5 relapse or @entity3 . The close survey of the @entity1 (by clinical exam, imaging and biological markers) is ongoing. The onset of asymptomatic @entity788 may have atypical respiratory symptoms. Imaging methods (ultrasound, contrast CT) are recommended in borderline symptomatology. Radical surgical resection of the @entity5 with lymphadenectomy, histopathology with immuno-histochemistry play an essential role in the correct diagnostic, grading, staging and treatment of pancreatic @entity5 . Close survey of the clinical, imagistic and biological markers is recommended.
