XXXX in @entity1 with impaired left ventricular function undergoing coronary artery bypass grafting-- @entity7604 versus nifedipin.

@entity1 @entity296 @entity308 @entity908 @entity1188 @entity2473 @entity594 @entity7604 @entity2553
BACKGROUND AND OBJECTIVE: @entity296 and @entity1188 are major complications immediately after coronary artery bypass grafting. They may be due to incomplete surgical revascularization, perioperative anaesthetic management or @entity2553 of arterial grafts, e.g. the internal mammary artery. Infusions of @entity594 or @entity7604 have been advocated to prevent @entity2473 of the mammary artery. The study compared the incidence of @entity296 after continuous infusion of either @entity594 (0.2 microg kg(-1) min(-1)) or @entity7604 (0.375 microg kg(-1) min(-1)) in @entity1 with compromised left ventricular function scheduled for elective coronary artery bypass graft. METHODS: After Institutional Review Board approval, this double-blinded randomized clinical study enrolled 30 adult @entity1 with compromised left ventricular function (ejection fraction < 0.4) scheduled for elective coronary artery bypass grafting after written informed consent had been obtained. Ischaemia was detected by Holter electrocardiographic monitoring. The incidence of @entity296 death was monitored by serial determinations of the @entity908 kinase-MB (CK-MB) and troponin-I. RESULTS: New ST elevation > or = 0.2 mV or new ST @entity308 < or = 0.1 mV occurred in five of 15 @entity1 in the @entity7604 group (33.3%) and in 13 of 15 @entity1 (86.6%) in the @entity594 group (P < 0.05). There were increases in CK-MB and troponin-I in both groups. Twenty-four hours postoperatively, CK-MB (P = 0.003) and troponin-I (P = 0.001) were significantly higher in the @entity594 group. CONCLUSIONS: Perioperative continuous infusion of @entity7604 , compared with @entity594 , results in a significantly lower incidence of @entity296 and @entity296 damage after elective coronary artery bypass grafting.
