Osteoarticular complications of XXXX : The diagnostic value and importance of detection matrix metalloproteinases.

@entity1 @entity3334 @entity3377 @entity5 @entity1495 @entity792
OBJECTIVES: Matrix metalloproteinases (MMPs) has been implicated in the pathogenesis of infective, @entity5 and @entity792 . In this study, we investigated the serum level of MMPs and its clinical importance in @entity1 @entity3377 . @entity1 AND METHODS: This study included 60 @entity3377 @entity1 treated at the Clinic for Infectious Diseases, Clinical Centre, University of Sarajevo. Matrix metalloproteinases serum levels were quantified by ELISA. RESULTS: The investigation involved three groups: 30 @entity1 with complications, 30 @entity1 without complications of @entity3377 and 30 healthy control examinees. The complications of @entity1 @entity3377 varied but osteoarticular involvement dominated (n=21/30; 70%). Matrix metalloproteinases serum levels in the @entity1 with complications were highest. The serum level of @entity3334 in @entity1 with complications was the highest at 9.45; in @entity1 without complications it was 3.78 and in the control examinees it was lowest at 3.62 (p=0.001). The serum level of @entity1495 in @entity1 with complications was the highest at 105.66; in @entity1 without complications 64.67, and in the control examinees it was lowest at 37.32 (p=0.001). The serum level of MMP-13 in @entity1 with complications was highest at 138.86; in @entity1 without complications at 64.85; and in the control examinees it was the lowest at 29.55 (p=0.001). Pearson's coefficient showed a statistically significant positive correlation between levels of tested matrix metalloproteinases and development complications in @entity1 @entity3377 (p=0.001). CONCLUSION: This study showed the diagnostic value and importance of detection of matrix metalloproteinases in @entity1 @entity3377 . MMPs are a useful serum biomarker for assessment of disease activity.
