Clinical Prognosis in Neonatal XXXX : The Role of Cerebrospinal Fluid Protein.

@entity1 @entity1087 @entity4008 @entity146 @entity55 @entity16 @entity693 @entity413 @entity386
UNASSIGNED: Neonates are at high risk of @entity693 and of resulting @entity16 . Early recognition of neonates at risk of poor prognosis would be helpful in providing timely management. From January 2008 to June 2014, we enrolled 232 term neonates with @entity4008 admitted to 3 neonatology departments in Shanghai, China. The clinical status on the day of discharge from these hospitals or at a postnatal age of 2.5 to 3 months was evaluated using the Glasgow Outcome Scale (GOS). @entity1 were classified into two outcome groups: good (167 cases, 72.0%, GOS = 5) or poor (65 cases, 28.0%, GOS = 1-4). Neonates with good outcome had less frequent @entity386 , drowsiness, poor feeding, bulging fontanelle, @entity146 and more severe @entity1087 compared to neonates with poor outcome. The good outcome group also had less @entity55 than the poor outcome group. Besides, there were statistically significant differences in hemoglobin, mean platelet volume, platelet distribution width, C-reaction protein, procalcitonin, cerebrospinal fluid (CSF) @entity413 and CSF protein. Multivariate logistic regression analyses suggested that poor feeding, @entity55 and CSF protein were the predictors of poor outcome. CSF protein content was significantly higher in @entity1 with poor outcome. The best cut-offs for predicting poor outcome were 1,880 mg/L in CSF protein concentration (sensitivity 70.8%, specificity 86.2%). After 2 weeks of treatment, CSF protein remained higher in the poor outcome group. High CSF protein concentration may prognosticate poor outcome in neonates with @entity4008 .
