Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a XXXX Care Editors' Expert Forum.

@entity353 @entity6 @entity28 @entity164 @entity209 @entity65
As @entity28 rates increase, so too do the risks of @entity164 2 @entity6 , @entity65 , and numerous other detrimental conditions. The prevalence of @entity28 in U.S. adults more than doubled between 1980 and 2010, from 15.0 to 36.1%. Although this trend may be leveling off, @entity28 and its individual, societal, and economic costs remain of grave concern. In June 2014, a @entity6 Care Editors' Expert Forum convened to review the state of @entity28 research and discuss the latest prevention initiatives and behavioral, medical, and surgical therapies. This article, an outgrowth of the forum, offers an expansive view of the @entity28 epidemic, beginning with a discussion of its root causes. Recent insights into the genetic and physiological factors that influence body weight are reviewed, as are the pathophysiology of @entity28 -related @entity209 and the concept of metabolically healthy @entity28 . The authors address the crucial question of how much @entity353 is necessary to yield meaningful benefits. They describe the challenges of behavioral modification and predictors of its success. The effects of @entity6 pharmacotherapies on body weight are reviewed, including potential weight-neutral combination therapies. The authors also summarize the evidence for safety and efficacy of pharmacotherapeutic and surgical @entity28 treatments. The article concludes with an impassioned call for researchers, clinicians, governmental agencies, health policymakers, and health-related industries to collectively embrace the urgent mandate to improve prevention and treatment and for society at large to acknowledge and manage @entity28 as a serious disease.
