Tissue factor expression in atrial endothelia associated with XXXX : possible involvement in intracardiac thrombogenesis.

@entity1 @entity32 @entity2194 @entity409 @entity49 @entity3457 @entity1031 @entity955 @entity715 @entity2401 @entity2880
INTRODUCTION: Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. @entity2401 has been detected recently in some @entity1 with lone @entity955 . Virchow's triad of low blood flow, @entity49 , and @entity409 , enhances @entity715 formation. The present study was designed to elucidate the role of @entity409 in thrombogenesis associated with @entity955 . MATERIAL AND METHODS: We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven @entity1 with @entity955 and cardiogenic @entity1031 . Tissues were divided into 7-13 sections and compared with control specimens from four @entity1 who died of noncardiac events. Expression of tissue factor, @entity2880 factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. RESULTS: Histopathologically, inflammatory cells infiltrated the endocardium and all seven @entity1 showed features of persistent @entity2401 . @entity3457 cells [15.3+/-9.4 @entity2194 ( @entity2194 , mean+/-S.D.) vs. control 2.2+/-4.4/ @entity2194 (P=0.0294)] and a few macrophages [5.1+/-8.4 cells/ @entity2194 vs. control 2.4+/-3.5 cells/ @entity2194 (P=NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. @entity2880 factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. CONCLUSION: Tissue factor expression induced by @entity32 is involved in the pathogenesis of @entity715 in @entity1 with @entity955 .
