Strawberry Phytochemicals Inhibit Azoxymethane/Dextran Sodium Sulfate-Induced Colorectal Carcinogenesis in Crj: CD-1 XXXX .

@entity1 @entity19 @entity5 @entity1994 @entity694
UNASSIGNED: @entity1 and experimental @entity694 are enhanced by a pro-inflammatory microenvironment. Pharmacologically driven chemopreventive agents and dietary variables are hypothesized to have future roles in the prevention of @entity694 by targeting these processes. The current study was designed to determine the ability of dietary lyophilized strawberries to inhibit inflammation-promoted @entity694 in a preclinical animal model. @entity19 were given a single i.p. injection of azoxymethane (10 mg kg-1 body weight). One week after injection, @entity19 were administered 2% (w/v) dextran sodium sulfate in drinking water for seven days and then an experimental diet containing chemically characterized lyophilized strawberries for the duration of the bioassay. @entity19 fed control diet, or experimental diet containing 2.5%, 5.0% or 10.0% strawberries displayed @entity5 incidence of 100%, 64%, 75% and 44%, respectively (p < 0.05). The mechanistic studies demonstrate that strawberries reduced expression of proinflammatory mediators, suppressed nitrosative stress and decreased phosphorylation of phosphatidylinositol 3-kinase, @entity1994 , extracellular signal-regulated kinase and nuclear factor kappa B. In conclusion, strawberries target proinflammatory mediators and oncogenic signaling for the preventive efficacies against @entity694 in @entity19 . This works supports future development of fully characterized and precisely controlled functional foods for testing in @entity1 clinical trials for this disease.
