Hemodynamic effects of calcium antagonists in cardiac XXXX .

@entity1 @entity64 @entity7220 @entity301 @entity1855 @entity591
Hemodynamic studies were carried out after cardiac catheterization with a floatation catheter in the pulmonary artery and cannulation of the brachial artery for the calculation of cardiac output by means of the Fick principle. Continuous pressure recordings were carried out at rest and under submaximal treadmill exercise in the supine body position in 5 homogeneous groups of 12 @entity1 , all with disorders due to @entity301 . In a control test, hemodynamic investigations were carried out at rest before medication, under stress and after recovery. Similar tests were performed after intravenous administration of either isotonic saline as placebo, @entity7220 (1.1 and 1.6 mg/kg) or @entity1855 (0.07 and 0.14 mg/kg). It was shown that there was a marked dose-related reduction in peripheral vascular resistance with a maximum effect occurring at 2-5 min after the intravenous administration of @entity7220 (1.1 and 1.6 mg/kg) reaching 23 and 39%, respectively, or @entity1855 (0.07 and 0.14 mg/kg) attaining 28 and 39%, respectively, at rest and, to a similar extent, under stress conditions. In @entity1 with sinus rhythm, the mean arterial pressure was reduced. Cardiac outputs and @entity64 volumes were increased at rest as well as under stress. There was no evidence of a depressant action of the drug on hemodynamic variables. An interplay of simultaneous changes in preload and afterload seems to be responsible for the effects obtained. The doses used were those commonly employed in the termination of supraventricular @entity591 . However, a potential depressant effect of @entity7220 in @entity1 with markedly reduced ventricular function is not excluded by this study.
