Coancestry in apparently XXXX .

@entity1 @entity120
OBJECTIVE: To examine sporadic cases of @entity120 of coancestry. DESIGN: An epidemiologic study of families of @entity1 with @entity120 . SETTING: A university-affiliated referral population. @entity1 : Family members of 13 @entity1 with @entity120 . MEASUREMENTS: Family pedigrees involving grandparents, parents, siblings, and @entity1 were supplemented by genealogic records. Coefficients of kinship (Ck) were calculated for the @entity1 with @entity120 who demonstrated coancestry and compared with 500 sets of controls drawn at random from genealogic records. RESULTS: Two @entity1 with @entity120 demonstrated coancestry. The great-great grandfather and great-great grandmother of one @entity1 were the great-grandfather and great-grandmother of the other @entity1 . No other cases of @entity120 were identified in these two families. The CK of the affected individuals (CK = 10.02 x 10(-5)) suggests strongly that the observed relationship did not occur by chance alone. Among 500 random sets of matched controls, only two sets yielded CK of 10.02 x 10(-5) or greater (p = 0.004). Coancestry could not be identified for the other five families of @entity1 with @entity120 for whom genealogic records were available. CONCLUSIONS: The finding of coancestry in @entity1 with @entity120 suggests that a genetic basis exists for some @entity1 with apparently @entity120 . @entity120 may be more common than previously recognized.
