An epidemic of maternal XXXX associated with elevated antiplatelet antibody. Platelet count and antiplatelet antibody in 116 consecutive pregnancies: relationship to neonatal platelet count.

@entity1 @entity3039 @entity882
Twenty-eight (24%) of 116 pregnant @entity1 studied prospectively during an 8-month period in 1983 had platelet counts of less than 150,000/mm3 at least once during pregnancy. Thirteen of these were @entity882 in both the prenatal and the peripartum period. Eighteen were restudied 3 to 12 months after delivery. One @entity1 , who was pregnant again, had a platelet count of 140,000/mm3. In the others, platelet counts were in the normal range. Platelet-associated immunoglobulin G and serum antiplatelet antibody levels were elevated in 79% and 61%, respectively, of these 28 @entity1 on at least one occasion. However, 59% of 73 pregnant nonthrombocytopenic @entity1 had increased platelet-associated immunoglobulin G levels and 59% had positive serum antiplatelet antibody test results. Twenty @entity1 who had increased platelet-associated immunoglobulin G levels and positive serum antiplatelet antibody test results were normal 6 to 10 months after delivery. Of 105 @entity1 studied, 10 were @entity882 . @entity882 was not predicted by maternal platelet count, platelet-associated immunoglobulin G, or serum antiplatelet antibody. By the fall of 1984, the incidence of @entity882 had dropped to two in 280 consecutive pregnancies. We conclude that (1) epidemics of @entity882 can occur in pregnant @entity1 and (2) if a @entity1 is found to be @entity882 for the first time during pregnancy, she should not be subjected to the measures advocated for the management of pregnancy in @entity1 with @entity3039 .
