Experimental production of poststenotic dilatation in the carotid arteries of XXXX .

@entity101 @entity575 @entity1373 @entity95 @entity850
Arterial dilatation distal to a @entity850 has been known as poststenotic dilatation (PSD). This paper describes arterial constriction enough to produce PSD, time course of PSD, structural changes of the dilated segments and influence of @entity101 on the development of PSD. These problems were studied in 2 experimental protocols. In protocol I, 87 carotid arteries of 45 @entity95 were constricted by @entity575 clip of 0.65 to 2.0 mm in diameter. The arterial diameter was measured at the sites both proximal and distal to the constriction after 3 days to 8 weeks. In protocol II, 22 carotid arteries of 12 @entity95 with experimental one-or two-kidney Goldblatt @entity101 were constricted and the development of PSD was compared with age matched controls. Remarkable PSD developed in arteries with moderate @entity850 of 45 to 60% constriction. The degree of dilatation expressed as ratio of distal to proximal diameter reached about 1.5 at the end of the second week and remained unchanged thereafter. Destruction of the elastic fibers with intimal @entity1373 was observed in the dilated segments even at the early stages of the PSD. Both mild and severe @entity850 failed to produce prominent PSD. In protocol II, the PSD averaged 1.18 +/- 0.05 (mean +/- SE) in @entity101 , and 1.32 +/- 0.03 in normotensive animals (p less than 0.05). The result suggests that chronic @entity101 decreases the distensibility of the arteries.
