9A.08: INTERLEUKINS 33 AND @entity1356 SERUM LEVELS ARE CONNECTED TO COMMON CAROTID ARTERIES REMODELING IN HYPERTENSIVE XXXX WITH OBESITY.

@entity1 @entity101 @entity28 @entity1356 @entity1184 @entity2998 @entity6889
OBJECTIVE: To investigate interrelations between @entity6889 ( @entity6889 ) and @entity1356 ( @entity1356 ) serum levels and common carotid arteries (CCA) remodeling in @entity101 @entity1 with @entity28 . DESIGN AND METHOD: 80 @entity101 @entity1 (51 obese) have been observed. An ultrasound examination of CCA with estimation of its geometrical type was performed (cut-off value for vascular wall @entity1184 was vascular segment mass >0,275g/cm, concentric remodeling was diagnosed with relative wall thickness of CCA >0,2). @entity6889 and @entity1356 serum levels were estimated using ELISA. RESULTS: @entity6889 and @entity1356 levels were higher in @entity101 @entity1 (p<0,001), independently of BMI. Cluster analysis was made to reveal both cytokines' levels impact on CCA geometry. @entity6889 >73pg/ml, @entity1356 >25pg/ml was associated with 80,0% prevalence of normal CCA geometry and 20,0% of its @entity1184 . @entity1356 >20pg/ml with @entity6889 <71pg/ml was characterized by 80,0% prevalence of normal geometry, 10,0% of non- @entity101 concentric remodeling of CCA, 5,0% of concnetric and 5,0% of @entity1184 . @entity6889 >71pg/ml with @entity1356 <25pg/ml was associated with decrease of normal CCA geometry prevalence to 50,0% with increase of @entity1184 rate to 41,7%; other 8,3% @entity1 had @entity2998 . @entity6889 <71 pg/ml, @entity1356 <20pg/ml (p>0,05 vs control group) had 57,9% of normal geometry, 15,8% of concentric remodeling, 15,8% of concnetric @entity1184 and 10,5% of @entity2998 . CONCLUSIONS: @entity6889 and @entity1356 serum levels were elevated in @entity101 @entity1 independently of presence of @entity28 . A pronounced isolated increase in @entity6889 level was associated with abrupt increase of CCA @entity1184 prevalence, especially its concentric variant. Accompanying increase in @entity1356 level reduced this effect.
