Relationship between height at diagnosis and @entity5 in young XXXX : a meta-analysis.

@entity1 @entity2828 @entity5494 @entity5 @entity421
OBJECTIVE: Some evidence exists that @entity1 with @entity421 and @entity2828 are taller than the general population. However, previous studies are under-powered, lack comprehensive data and show inconsistencies. METHODS: Relevant studies linking @entity421 and @entity2828 with height at diagnosis were identified in two major online databases, Medline (1950 to 2009) and Embase (1980 to 2009). Outcomes in individual studies were reported as @entity5494 ( @entity5494 ) scores or percentages of study population with height at diagnosis above the median of the reference population. We performed separate random-effects meta-analyses for each outcome and @entity5 type. RESULTS: 14 studies examined the height of @entity1 with @entity421 or @entity2828 . Meta-analyses on @entity5494 scores found @entity1 with @entity421 were 0.260 @entity5494 (95% CI: 0.088-0.432) taller than the reference population (five studies). A meta-analysis on percentages found 62% (95% CI: 57%-67%) of @entity1 were estimated to have a height above the median (six studies). @entity1 with @entity2828 were 0.096 @entity5494 (95% CI 0.004-0.188) taller (four studies). Only one study reported the percentage of @entity2828 @entity1 with height above the median. CONCLUSION: The average height of @entity1 with @entity421 , but not @entity2828 , was significantly above the average height of the reference population by 2-3 centimetres. The observed differences indicate the involvement of pubertal longitudinal bone growth in @entity421 development while different biological pathways could be relevant for @entity2828 .
