In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After XXXX With Multimodal MRI and OCT.

@entity2194 @entity17 @entity921 @entity19 @entity3391 @entity989 @entity35 @entity528 @entity130
PURPOSE: Excitotoxicity has been linked to the pathogenesis of @entity2194 and @entity130 and may involve @entity528 of both anterior and posterior visual pathways. However, their spatiotemporal relationships remain unclear. We hypothesized that the effects of excitotoxic @entity989 (ERI) on the visual system can be revealed in vivo by diffusion tensor magnetic resonance imagining (DTI), @entity921 -enhanced magnetic resonance imagining (MRI), and optical coherence tomography (OCT). METHODS: Diffusion tensor MRI was performed at 9.4 Tesla to monitor white matter integrity changes after unilateral @entity3391 ( @entity3391 )-induced ERI in six @entity35 and six C57BL/6J @entity19 . Additionally, four @entity35 and four @entity19 were intravitreally injected with saline to compare with @entity3391 -injected animals. Optical coherence tomography of the retina and @entity921 -enhanced MRI of anterograde transport were evaluated and correlated with DTI parameters. RESULTS: In the @entity35 optic nerve, the largest axial diffusivity decrease and radial diffusivity increase occurred within the first 3 and 7 days post ERI, respectively, suggestive of early @entity528 and delayed @entity17 . The optic tract showed smaller directional diffusivity changes and weaker DTI correlations with retinal thickness compared with optic nerve, indicative of anterograde degeneration. The splenium of corpus callosum was also reorganized at 4 weeks post ERI. The DTI profiles appeared comparable between @entity35 and @entity19 models. Furthermore, the @entity3391 -injured visual pathway showed reduced anterograde @entity921 transport, which correlated with diffusivity changes along but not perpendicular to optic nerve. CONCLUSIONS: Diffusion tensor MRI, @entity921 -enhanced MRI, and OCT provided an in vivo model system for characterizing the spatiotemporal changes in white matter integrity, the eye-brain relationships and structural-physiological relationships in the visual system after ERI.
