Laboratory assessment of warfarin reversal with XXXX tests versus international normalized ratio in @entity1 with @entity510 .

@entity3459 @entity1 @entity556 @entity510
We assess the in-vivo relationship between international normalized ratio (INR) and @entity3459 tests in @entity1 with life-threatening bleeding who received prothrombin complex concentrate (PCC) for warfarin reversal. This was a prospective pilot study in adult @entity1 with @entity510 related to anticoagulation with warfarin. Thromboelastography (TEG), @entity556 generation parameters and INR were assessed at baseline, 30 min, 2 and 24 h after PCC. Changes in laboratory parameters and relationship between INR and @entity3459 tests were assessed over time. Eight @entity1 mean [standard deviation (SD)] age 72 (16) were included and received mean (SD) dose of PCC 24 (5)units/kg. Four @entity1 died during the study, all with INR values more than 1.5 thirty minutes after PCC. Mean (SD) INR was 3.0 (1.3) and decreased significantly to 1.8 (0.48) thirty minutes after PCC (P<0.01). Baseline endogenous @entity556 potential and @entity556 peak were 890 nmol/min and 123 nmol and increased significantly to 1943 nmol/min (P<0.01) and 301 nmol (P<0.01) 30 min after PCC administration. Reaction (R)-time decreased significantly (P=0.02), and maximum amplitude and overall coagulation index (CI) significantly increased during treatment (P<0.01, respectively). @entity556 generation and TEG values corrected after PCC administration; however, INR did not fully correct. @entity1 that died tended to be older with prolonged INR values across the study period. INR and TEG values correlated well with @entity556 generation before administration of PCC, but this relationship was lost afterward.
