XXXX . Clinical evaluation of 32 cases.

@entity1 @entity249 @entity11157 @entity170 @entity7793
AIM: @entity7793 , also termed @entity11157 ( @entity11157 ), is characterized by cessation of menstruation before the age of 40 years. Pathogenetic mechanisms are not so clear, particularly genetic implications of cellular apoptosis. Diagnostic approach is multifactorial and therapy depends on the pregnancy wish. METHODS: Eight hundred and thirty @entity1 approached the Menopausal Center of the University Department of Gynaecological, Obstetrical and Reproductive Sciences of the Second University of Naples between October 1998 and October 2002. All @entity1 were clinically investigated and selected on the basis of menopausal age, pregnancy wish and @entity7793 . RESULTS: Menopausal mean age was 48.31+/-4.62 years and 32 @entity1 (4%) were affected by @entity11157 because of menopausal appearance before the age of 40. Three of these @entity1 were treated to have a pregnancy; the remaining 29 required medical treatment to reduce menopausal symptoms. The @entity170 risk for @entity7793 @entity1 was similar to the other @entity1 . The cardiovascular risk was increased because of an increase in risk factors in @entity11157 @entity1 . No breast or endometrial pathology was revealed and therapy compliance was satisfactory without any drop-out. CONCLUSION: @entity11157 has a varied etiology, pathogenetic aspects, clinical evolution and therapeutical approach. Adequate treatment of @entity7793 @entity1 presents good compliance, resolution of @entity249 when required and a successful resolution of menopausal symptoms.
