Low microvessel density is an unfavorable histoprognostic factor in XXXX .

@entity1 @entity788 @entity7 @entity5 @entity189 @entity3 @entity2280
BACKGROUND AND AIMS: In many @entity5 , intratumoral microvascular density (MVD) has been suggested to be a prognostic parameter. We aimed to provide a quantitative evaluation of intratumoral microvascular density in a large series of resected endocrine @entity5 of the pancreas and to evaluate the potential prognostic significance of this parameter. METHODS: Eighty-two @entity5 from 77 @entity1 have been studied. MVD was evaluated by 2 observers after @entity2280 immunostaining and correlated with the following parameters: WHO classification, hormonal profile, @entity5 size, @entity7 expression, occurrence of @entity3 , duration of survival. RESULTS: MVD ranged from 5 to 92 vessels/field. MVD was significantly higher in well-differentiated @entity5 of uncertain behavior and in @entity189 . No close correlation was found between MVD and the hormonal profile. MVD was significantly higher in @entity5 characterized by the following histoprognostic parameters: size <2 cm, proliferation index <2%, no evidence of @entity3 . No close correlation was observed between MVD and @entity7 expression. Finally, a MVD <30 vessels/field was associated with the occurrence of @entity3 in @entity5 <2 cm and/or with a proliferation index <2% and with a significantly shorter survival after surgery. CONCLUSIONS: The quantitative analysis of microvessel density in @entity788 may identify @entity1 who, despite favorable conventional histoprognostic factors, are at risk of unfavorable evolution.
