Age and the neuromuscular blockading effects of XXXX .

@entity1 @entity3370 @entity2897 @entity4094
PURPOSE: To investigate the influence of age on the neuromuscular blocking effect of @entity2897 . METHODS: 90 @entity1 with ASA I and II were assigned to the following groups according to their age: adults, @entity1 , and @entity1 . Each group was subdivided into three subgroups according to the first dose of @entity2897 . @entity1 were administrated at a first dose of @entity2897 randomly, and their responses to @entity3370 ( @entity3370 ) stimulation were observed. When the same degree of the first response (T1) continuously repeats three times, the percentage of T1 inhibition was recorded, and the curve of dose-effect relationship and ED95 were calculated. A second dose of @entity2897 was then administrated (total volume 100  g/kg). The recovery phase in each @entity1 was observed upon T1 reaching the maximum blocking effect (100%). RESULTS: Once the maximum blocking effect was reached, @entity1 were intubated. There were 83 cases (92.2%) of @entity1 with grade 1 and 7 (7.8%) @entity1 with grade 2 intubating conditions. ED95 was 59.29, 55.88 and 45.39  g/kg in adults, @entity1 , and @entity1 , respectively. ED95 positively correlated with age. The clinical duration of @entity4094 , effective action duration of @entity4094 , and in vivo action duration of @entity4094 in adults was longer than that in @entity1 (P<0.05), but shorter than in @entity1 (P<0.05). However, there were no significant differences in the recovery index among groups (P>0.05). CONCLUSION: Age influences the neuromuscular blocking effects of @entity2897 to a certain extent.
