Effect of dietary hyperlipidemic components and fish oil on concentration of lipids in liver and liver XXXX profile of @entity35 .

@entity5204 @entity844 @entity1474 @entity6221 @entity10194 @entity382 @entity35 @entity8981 @entity1718 @entity165
This investigation was attempted to clarify the effects of dietary hyperlipidemic components and fish oil on concentration of lipids in liver and liver @entity844 profile of @entity35 . In a first experiment male @entity35 were maintained on a semipurified low-fat diet with 6.5% coconut oil and 1.5% safflower oil, but without added @entity165 , or a high-fat hyperlipidemic diet supplemented with 7.3% coconut oil, 7.3% beef tallow, 0.4% safflower oil, and 1.5% @entity165 for 28 days. @entity35 fed the hyperlipidemic diet were then switched to fish oil diets with 1.4%, 2.8%, and 5.6% fish oil in exchange for coconut oil and beef tallow for, respectively, 10 and 20 days. In a second experiment male @entity35 were fed low-fat or high-fat diets without or with 1.5% added @entity165 for 28 days. Half of each group was then changed to a fish oil diet (for 20 days) which contained 5.6% fish oil in exchange for coconut oil and beef tallow. In experiment 1, @entity35 fed the hyperlipidemic diet @entity382 within 28 days. Experiment 2 showed that @entity165 in the diet was responsible for the accumulating liver lipids. Feeding diets with added @entity165 , the proportions of @entity1718 ( @entity10194 ), especially 18:0, were markedly reduced in liver, whereas levels of @entity6221 ( @entity8981 ) were greatly increased compared to diets without added @entity165 . This increase was most pronounced with respect to 16:1 and 18:1. In contrast, fish oil diets lowered @entity8981 level in liver in spite of its high @entity8981 content. @entity35 fed the highly saturated hyperlipidemic diet low in 18:2 n-6 had reduced 18:2 n-6 levels in liver compared to @entity35 fed the low-fat diet without added @entity165 . Also, 20:4 n-6 level in liver was markedly reduced after the administration of the hyperlipidemic diet or the fish oil diets. Results of experiment 2 elucidate that @entity165 as well as fish oil sharply lowered 20:4 n-6 level in liver, which might be due to a reduced desaturation. In both experiments feeding fish oil increased all long-chain n-3 @entity1474 ( @entity5204 ) in liver. This occurred in a dose-dependent fashion and reached a maximum level with 5.6% fish oil in the diet. When additional @entity165 was applied 22:6 n-3 level in liver fell. This indicates also an impaired desaturation of @entity5204 due to dietary @entity165 .
