The relationship between lipids/lipoproteins and @entity731 in African Americans and whites: the XXXX Risk in Communities Study.

@entity1004 @entity1 @entity1674 @entity9478 @entity755 @entity9477 @entity731 @entity165
PURPOSE: The relationships between lipids/lipoproteins and @entity731 were determined in African Americans and whites to assess the consistency of the relationship between these two groups. Differences could suggest varying biological, environmental, or life-style cofactors influencing development of @entity731 . METHODS: In the @entity731 Risk in Communities Study, 2966 African Americans and 9399 whites had determinations of LDL, HDL, @entity9477 , and @entity9478 @entity165 , @entity1674 , @entity755 , and lipoprotein (a). Carotid @entity1004 ( @entity1004 ) was measured using B-mode ultrasound imaging. RESULTS: The associations, using linear regression, between carotid @entity1004 and LDL @entity165 , HDL @entity165 , and other lipid measurements were significantly weaker in African Americans than whites. Averaging @entity1 and @entity1 , a 1.034 mmol/L (40 mg/dl) difference in LDL @entity165 was associated with a 0.028 mm @entity1004 difference in whites but a 0.019 difference in African Americans. Similarly, for HDL @entity165 , a 0.44 mmol/L (17 mg/dl) difference is associated wth 0.026 mm difference in carotid @entity1004 in whites and 0.011 mm difference in African Americans. The associations are much weaker in African Americans than whites at the bifurcation and internal carotid, the carotid sites most prone to @entity731 . Analysis was done stratifying for risk factors that differ between African Americans and whites, but within most, the relationships remained substantially weaker in African Americans. CONCLUSIONS: We have observed a statistically significant difference in the association between many lipids/lipoproteins and carotid @entity1004 between African Americans and whites. Analysis of many potential cofactors have not provided an explanation for the weaker association. Although possible differences in prior levels of these lipids may provide one explanation for the finding, these results need confirmation in other studies.
