Decision-making performance in XXXX correlates with lateral orbitofrontal volume.

@entity1 @entity550 @entity304 @entity191
BACKGROUND: @entity1 with @entity191 ( @entity191 ) exhibit poor decision-making, and the underlying neural correlates are unclear. We used voxel-based morphometry with Diffeomorphic Anatomical Registration through Exponentiated Lie algebra to examine this issue. METHODS: The decision-making abilities of 20 @entity1 with @entity191 and 37 healthy controls (HCs) were measured with a computerized Iowa Gambling Task (IGT). We assessed the local gray matter volumes of the @entity1 and HCs and their correlations with decision-making performance, disease duration, disease severity, and anti- @entity304 medication dose. RESULTS: Compared with the HCs, the @entity1 with @entity191 exhibited poor IGT performances. The gray matter volumes in the medial orbitofrontal cortex, @entity550 , and right middle frontal gyrus were decreased in the @entity1 . Results in the regression analysis showed that lateral orbitofrontal volume correlated with performance in the IGT in @entity191 . Regions that correlated with disease duration, severity, and medication dose did not overlap with orbitofrontal regions. CONCLUSION: Our results indicate that the lateral and medial orbitofrontal cortex are related to decision-making in @entity191 @entity1 . Since the medial orbitofrontal cortex is shown to be involved in monitoring reward, reward monitoring seems to be impaired as a whole in @entity191 @entity1 . Meanwhile, the lateral region is related to evaluation of punishment, which is considered to have an influence on individual differences in decision-making performance in @entity191 @entity1 .
