Single region of interest versus multislice T2* MRI approach for the quantification of hepatic XXXX overload.

@entity1 @entity8674 @entity797 @entity68
PURPOSE: To evaluate the effectiveness of the single ROI approach for the detection of hepatic @entity68 burden in @entity8674 ( @entity8674 ) @entity1 in respect to a whole liver measurement. MATERIALS AND METHODS: Five transverse hepatic slices were acquired by a T2* gradient-echo sequence in 101 @entity8674 @entity1 and 20 healthy subjects. The T2* value was calculated in a single region of interest (ROI) defined in the medium-hepatic slice. Moreover, the T2* value was extracted on each of the eight ROIs defined in the functionally independent segments. The mean hepatic T2* value was calculated. RESULTS: For @entity1 , the mean T2* values over segments VII and @entity797 were significantly lower. This pattern was substantially preserved in the two groups identified considering the T2* normal cutoff. All segmental T2* values were correlated with the single ROI T2* value. After the application of a correction map based on T2* fluctuations in the healthy subjects, no significant differences were found in the segmental T2* values. CONCLUSION: Hepatic T2* variations are low and due to artifacts and measurement variability. The single ROI approach can be adopted in the clinical arena, taking care to avoid the susceptibility artifacts, occurring mainly in segments VII and @entity797 .
