@entity6126 is not an independent predictor of high-risk disease in XXXX undergoing radical prostatectomy.

@entity1 @entity251 @entity263 @entity6126 @entity1486
BACKGROUND: A study was undertaken to assess the association between either preoperative serum total @entity251 (TT) or @entity6126 (defined as TT <3 ng/mL) with high-risk @entity263 ( @entity263 ) (defined as @entity1 with pathological extracapsular extension [ECE], seminal vesicle invasion [SVI], or Gleason grades >= 4 + 3 [high-grade @entity263 ]) at radical prostatectomy (RP). METHODS: A cohort of 673 consecutive Caucasian-European @entity1 who underwent RP at a single institute was used. None of the @entity1 had taken any hormonal neoadjuvant treatment or other hormonal preparations during the previous 12 months. Serum TT was measured the day before surgery (8-10 AM) in all cases. Logistic regression models tested the associations among predictors (eg, @entity1486 , clinical stage, biopsy Gleason sum, body mass index, and TT) and ECE, SVI, and high-grade @entity263 . RESULTS: Median TT was 4.5 ng/mL (mean, 4.5; range, 0.02-13.6). @entity6126 was found in 144 (21.4%) @entity1 , and severe @entity6126 (defined as TT <1 ng/mL) was observed in 37 (5.5%) @entity1 . Extracapsular extension, SVI, and high-grade @entity263 were found in 96 (14.6%), 88 (13.1%), and 153 (22.7%) @entity1 , respectively. @entity1 with high-risk @entity263 had median TT comparable to those with low-risk disease. At multivariate analysis, TT did not achieve independent predictor status for ECE, SVI, and high-grade @entity263 . Only circulating TT <1 ng/mL was an independent predictor of SVI (odds ratio, 3.11; P = .006). CONCLUSIONS: In contrast with previous reports, preoperative circulating TT levels were not associated with high-risk @entity263 . Likewise, @entity6126 did not achieve independent predictor status for high-risk @entity263 .
