@entity20927 / XXXX translocation (14;19)(q32;q13) in @entity1893 .

@entity1 @entity1893 @entity66 @entity706 @entity146 @entity4812 @entity1072 @entity2109 @entity20927 @entity2935 @entity7513
The recurrent cytogenetic (CG) abnormality t(14;19)(q32;q13) involving the oncogene @entity20927 is described in @entity1 with atypical @entity1072 ( @entity1072 ). We report four @entity1 with @entity1893 ( @entity1893 ) bearing t(14;19). All cases were female and their age ranged from 62 to 91. Histologically, there were two cases of @entity1072 ( @entity1072 ), both @entity2935 positive with atypical morphology, one case of @entity2109 ( @entity2109 ), and one case of @entity4812 ( @entity4812 ). One @entity1072 @entity1 showed t(14;19) as the sole abnormality and experienced a benign course for 8 years. The other three cases showed secondary CG progression, including tetraploidy, del(6q), t(8;22) and del(13q). These cases were @entity146 in clinical behavior, including an @entity1072 case which transformed to @entity706 in 4 months. Southern analysis and long distance PCR confirmed @entity20927 / @entity7513 Calpha translocation in one case. We propose that NHLs with t(14;19) may have evolved from the same spectrum of disease as @entity1072 . The poor prognosis of @entity66 is associated with the occurrence of recurrent secondary CG changes, commonly found in B cell lymphoproliferative diseases.
