Proposal of the performance status combined Japan Integrated Staging system in XXXX complicated with cirrhosis.

@entity1 @entity96 @entity5 @entity1575 @entity157 @entity1349
UNASSIGNED: The present study examined the prognostic ability of our proposed performance status combined Japan Integrated Staging (PS-JIS) system in @entity157 ( @entity157 ) @entity1 with @entity1575 ( @entity1575 ) comparing with other four prognostic systems including original JIS system, the Barcelona Clinic Liver Cancer classification system, TNM classification system and the @entity96 Italian Program (CLIP) scoring system. A total of 1,170 @entity157 @entity1 complicated with @entity1575 were analysed. The disease was staged for all analysed @entity1 by means of the five staging systems. The cumulative @entity1349 ( @entity1349 ) rate was calculated by Kaplan-Meier method and tested by log-rank test. We also examined prognostic factors associated with @entity1349 using univariate and multivariate analyses and compared the prognostic ability in each prognostic system using concordance index (c-index) at 1-, 3- and 5-year time-points. Overall significance in each prognostic system was P<0.001. In the multivariate analyses, @entity5 number, @entity1 -Pugh classification, PS, initial treatment modality and several laboratory parameters were significant independent predictors linked to @entity1349 . For all cases, in each time-point, the c-index of PS-JIS system was the highest among five staging systems (0.847, 0.816 and 0.808, respectively), indicating that PS-JIS system has the best predictability among these staging systems. According to subgroup analyses stratified by initial treatment modality, in @entity1 treated with surgical resection (n=205), CLIP scoring system had the highest c-index at every time-point, whereas in @entity1 treated with percutaneous ablative therapies (n=632) at 3- and 5-year time-point and in those with transcatheter arterial therapies (n=281) at every time-point, the c-index of PS-JIS system was the highest. In conclusion, the proposed PS-JIS score can be a useful prognostic system for @entity157 @entity1 complicated with @entity1575 .
