Interdependence of radial scar and proliferative disease with respect to XXXX risk in @entity1 with benign breast biopsies.

@entity1 @entity0 @entity66 @entity2318 @entity1373
BACKGROUND: @entity2318 ( @entity2318 ) are benign breast lesions that have been implicated as independent risk factors for @entity0 ( @entity0 ). METHODS: A retrospective cohort study of 9556 @entity1 who underwent biopsy between 1950-1986 and enrolled in the Nashville Breast Cohort was performed to investigate the association between @entity2318 in a benign breast biopsy and the risk of @entity0 . The risk associated with @entity2318 and coexistent @entity66 ( @entity66 ) was assessed adjusting for age at biopsy using a Cox hazards regression analysis with time-dependent covariates. RESULTS: @entity2318 were identified in 880 @entity1 (9.2%). The average follow-up time was 20.4 years. Sixty-two @entity1 (7.0%) with @entity2318 developed @entity0 compared with 5.5% of controls. The relative risk of @entity0 associated with @entity2318 was 1.82 (95% confidence interval [95% CI], 1.2-2.7) at 10 years. Restricting the analysis to @entity1 age > 49 years increased the risk to 2.14 (95% CI, 0.6-2.8). These risks decreased with increasing years of follow-up. Approximately 92% of @entity1 with @entity2318 also had @entity66 , but @entity2318 were present in only 1.3% of biopsies without @entity66 . Analyses stratifying relative risk with regard to @entity66 found @entity2318 to minimally elevate the relative risk of subsequent @entity0 . CONCLUSIONS: @entity2318 in the absence of @entity66 is uncommon. Although the presence of @entity2318 in a benign breast biopsy mildly elevates the risk of @entity0 risk, the current analysis indicated that this risk can be largely attributed to the category of coexistent @entity66 . In @entity1 with both @entity2318 and @entity1373 , recommendations for interventions beyond biopsy should be based on the extent of @entity1373 .
