Comparison of @entity2247 , Ki-67, and @entity588 expression in normal esophageal mucosa, @entity355 , dysplasia, and XXXX with postablation mucosa and implications for ablative therapies.

@entity1 @entity588 @entity355 @entity146 @entity5 @entity33 @entity1893 @entity2247 @entity420
BACKGROUND: The neosquamous mucosa that replaces ablated esophageal endothelium after @entity33 for @entity355 or @entity1893 ( @entity1893 ) may retain buried glandular tissue. This study aimed to assess the @entity5 potential, cellular proliferation, and resistance to apoptosis of this buried glandular tissue by measuring @entity2247 , Ki-67, and @entity588 expression in these tissues. METHODS: A prospectively collected database was sourced for esophageal biopsy specimens with normal histologic appearance, @entity355 , @entity1893 , @entity420 , and postablation mucosa comprising ablated Barrett's and ablated @entity1893 . Quantitative analysis of cellular markers was achieved immunohistochemically using monoclonal antibodies for the @entity2247 enzyme (suggesting increased @entity5 potential), Ki-67 antigen (suggesting cellular proliferation), and @entity588 oncoprotein (suggesting oncogenic resistance to apoptosis). Grading was performed by independent, blinded observers, and the pre- and postablation cellular disparities were subsequently noted. RESULTS: The buried glandular elements of postablation mucosa demonstrated universally greater @entity2247 , Ki-67, and @entity588 expression than normal esophagus. @entity355 and @entity420 expressed significantly greater @entity2247 and Ki-67 at the deep glandular level than postablation mucosa. @entity1893 demonstrated greater Ki-67 expression than the postablation tissue but only within the superficial glands. Overall, the expression of @entity2247 correlated significantly with Ki-67 expression in deep glandular tissue. CONCLUSIONS: Ablation of pathologic mucosa in @entity355 and @entity1893 reduces the expression of some markers of @entity146 . However, the buried glandular tissue of the postablation mucosa still exhibits a higher expression than normal esophageal epithelium. This has potential implications for the follow-up treatment of these @entity1 because it is unclear whether the true risk of @entity5 progression is adequately reduced. A more comprehensive study is required to address this issue.
