Effect of @entity2332 on intestinal adaptation and @entity105 in the XXXX .

@entity5 @entity2985 @entity86 @entity35 @entity105 @entity2332
@entity86 enhances experimental intestinal @entity105 , but the effects of nonsurgical adaptation are uncertain. The tropic and @entity5 -promoting potentials of moderate @entity2332 were tested in two groups of male @entity35 housed at 10 degrees C for 30 weeks. One group (n = 10) received a 6-week course of @entity2985 (total dose 90 mg kg-1). The second group (n = 7) acted as hypothermic controls. Another 2 groups maintained at 22 degrees C received @entity2985 (n = 15) or served as normothermic controls (n = 15). Overall food intake was 42% higher in the hypothermic groups, yet at sacrifice mean body weight was 13% lower (P less than 0.01). @entity2332 and @entity2985 combined to produce the following increases in crypt cell production rate (CCPR), as determined stathmokinetically: duodenum 170%, jejunum 172%, ileum 74%, proximal colon 227% (P = 0.05-0.01). Independently @entity2332 had no effect, but @entity2985 produced 76-156% increases in CCPR throughout the large intestine. Although @entity2332 did not affect overall @entity5 yield, the mean diameter of proximal @entity5 was increased by 65% (P less than 0.05). In @entity35 receiving @entity2985 , @entity2332 stimulates cell proliferation in the small bowel as well as in the proximal colon, where it has a correspondingly mild cocarcinogenic effect.
