Hemagglutinin protease secreted by XXXX induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses @entity5 growth in @entity19 model.

@entity27624 @entity1380 @entity1838 @entity5 @entity19 @entity899 @entity1379
UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity5 treatment. In this study we have shown antitumor activity of @entity27624 ( @entity27624 ) secreted by @entity1838 . One   g of @entity27624 showed potent antitumor activity when injected into Ehrlich ascites @entity5 in Swiss albino @entity19 . Weekly administration of this dose is able to significantly diminish a large @entity5 volume within 3  weeks and increases the survival rates of cancerous @entity19 . @entity27624 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity899 with increased ratio of pro-apoptotic @entity1380 to anti-apoptotic @entity1379 signify that @entity27624 induced apoptogenic signals lead to death of the @entity5 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity27624 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity27624 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity27624 may be used as a new candidate drug for @entity5 therapy.
