Endoscopic submucosal dissection for submucosal invasive XXXX and curability criteria.

@entity1 @entity3578 @entity5 @entity895 @entity189 @entity7453 @entity3 @entity356
AIMS: The aims of the present study were to evaluate the feasibility of endoscopic submucosal dissection (ESD) as curative treatment for node-negative @entity356 (EGC) and to consider further expansion of the curability criteria for submucosal invasive EGC. METHODS: A total of 977 EGC in 855 @entity1 treated by ESD were enrolled. They were divided into @entity5 (M); minimally @entity3 (<500  m from the muscularis mucosa) ( @entity895 ); and deeper @entity3 (>500  m from the muscularis mucosa) ( @entity3578 ). The technical feasibility of ESD for @entity895 and M were compared, and the clinical prognosis of @entity895 was evaluated. Furthermore, the volume of @entity189 invading to the submucosal layer, which we called the SM volume index, was calculated virtually to analyze its correlation with @entity7453 . RESULTS: There were no statistical differences in technical outcomes and complications between M and @entity895 . Curative resection rates were significantly better in M than in @entity895 (M, 92.6%; @entity895 , 63.8%). No local recurrences and distant @entity3 were found in 48 @entity895 @entity1 declared to have undergone curative resections. Most cases (72.0%) with successful ESD but non-curative resection exceeded 30mm in maximum size, and no local recurrences and @entity3 were found in these @entity1 . The SM volume index of these cases was comparatively small. CONCLUSION: The technical and theoretical validity of ESD for @entity895 was validated. The possibility of further expansion of the curability criteria for @entity3 was suggested by the evaluation of the SM volume index.
