ADAMTS Expression in XXXX .

@entity71332 @entity146 @entity5 @entity71331 @entity71330 @entity55655 @entity27369 @entity14 @entity3531 @entity17865
ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion, proliferation and migration. Through their thrombospondin motifs they also possess anti-angiogenic properties. We investigated whether ADAMTSs participate in @entity14 progression and invasion. Their expression was investigated at both mRNA and protein levels. Using RT-PCR, the expression of @entity17865 and @entity71330 was estimated in @entity14 of different @entity5 stage and anatomic site and 3 cell lines of different @entity146 . An overexpression of @entity55655 was observed, especially in tissue samples, whereas @entity71331 were found to be down-regulated. Western blot analysis further supported the RT-PCR findings, revealing in addition the degradation of @entity71331 in @entity5 . In situ expression and localization of @entity71332 was also investigated by immunohistochemical analysis. Our data suggest a positive correlation between @entity55655 expression and @entity5 progression, in contrast with the anti-angiogenic members of the family, @entity71331 , which were found to be down-regulated. Our findings support the notion that overexpression of @entity27369 and @entity3531 in @entity14 might be a possible invasive mechanism of @entity5 cells in order to degrade proteoglycans of ECM.
