Protective effect of intra-peritoneal XXXX on postoperative renal function after @entity900 -based intra-peritoneal intra-operative chemotherapy.

@entity1 @entity43 @entity8 @entity1425 @entity900 @entity177 @entity810 @entity1011 @entity551 @entity454
OBJECTIVES: Intra-operative @entity900 -based intra-peritoneal chemotherapy (IPC) may alter renal function in @entity1 with advanced @entity43 . The aim of this study was to describe postoperative alteration of renal function after @entity900 -based IPC and to identify risk factors for moderate to severe @entity810 . STUDY DESIGN: This prospective observational study was carried out on 77 consecutive @entity1 who underwent @entity900 -based IPC procedures, with (n=23) or without (n=54) intra-peritoneal @entity1425 , for advanced @entity43 . Postoperative renal function was assessed using serial serum creatinine measurements and was based on serum @entity1011 changes from pre-operative values, according to the risk, @entity177 , loss, @entity454 (RIFLE) classification. @entity1 were divided into two groups according to postoperative renal function: @entity1 with @entity8 or failure (IF group) or @entity1 with no renal alteration or renal risk (NR group). Clinical variables were compared between the IF and NR groups using univariate and multivariate analysis. RESULTS: Postoperative acute change in renal function was observed in 34 (44.2%) @entity1 (unimodal distribution), among whom 23 @entity1 (29.8%) constituted the IF group. In univariate analysis, the absence of @entity1425 in the IPC bath, a higher duration of severe @entity551 , a lower postoperative blood protein level, and a lower volume of intra-operative diuresis were significantly associated with the occurrence of @entity8 or failure. In multivariate analysis, the absence of @entity1425 was the only factor associated with the occurrence of moderate to severe @entity810 (odds ratio [95% confidence interval]=4.49 [1.36-14.80]). CONCLUSIONS: Transient @entity810 after @entity900 -based IPC associated with cytoreductive surgery is frequent and intra-peritoneal @entity1425 plays a protective role.
