@entity5379 in situ mRNA expression in @entity14 from Iraqi XXXX .

@entity1 @entity5379 @entity4998 @entity1476 @entity5 @entity3 @entity1495 @entity14 @entity420 @entity3271
@entity5379 ( @entity1476 and @entity1495 ) preferentially degrade the basement membrane, a key step in @entity5 invasion, @entity3 , and induction of vascularization of @entity5 tissue. AIM: To determine @entity1476 and @entity1495 in situ mRNA expressions in @entity14 from Iraqi @entity1 . MATERIALS AND METHODS: Forty archived paraffin-embedded @entity14 samples and their resection margins were enrolled in our study. Thin paraffin embedded sections (3-5  m thick) of both @entity5 and resection margins were prepared for each respective biopsy and were used to detect @entity1476 and @entity1495 in situ mRNA expressions based on in situ hybridization technique. STATISTICAL ANALYSIS: Statistical analyses were conducted to describe different variables and parameters in this research, and to describe relationships with each other as well. For the comparisons, the t test of significance was used. The associations were found by chi-square (  2 ) and analysis of variance (ANOVA) tests, or as appropriate, as well as 95% confidence interval. The correlations were calculated using correlation coefficient (r). Statistical significance was defined as P < 0.05. RESULTS: Based on the current outcome, there were significant differences in @entity1476 and @entity1495 in situ mRNA expressions when each @entity5 sample were compared to its respective resection margin (P < 0.001 and P < 0.001, respectively). When @entity5 samples were analyzed based on their depth of invasion, means of in situ mRNA expressions of both @entity1476 and @entity1495 were significantly increased in the group in which @entity5 invaded submucosa into muscularis properia (SMP) compared to that of @entity5 in serosa (SE) group and @entity5 invading other organs (OR) group (P < 0.05 and P < 0.05, respectively). Furthermore, when @entity5 lymph node @entity3 were questioned, exclusively, @entity1476 in situ mRNA expression was significantly differentiated among N0, N1, and N2 groups (P < 0.05). Regarding the possible correlation between the two investigated parameters with respect to various histopathological variables, both @entity1476 and @entity1495 in situ mRNA expressions have significant positive correlation in @entity5 samples (r = 0.88), whereas in resection margins, this correlation was absent. Interestingly, @entity1476 and @entity1495 in situ mRNA expressions were found to correlate positively as well as significantly within @entity5 differentiation [ @entity3271 ( @entity3271 ) @entity420 : r = 0.78; @entity4998 ( @entity4998 ) @entity420 : r = 0.90; and poorly differentiated (PD) @entity420 : r = 0.91], @entity5 stage (A-B: r = 0.70 and C-D: r = 0.95), depth of invasion (SMP: r = 0.77; SE: r = 0.87; and OR: r = 0.97), lymph node @entity3 (N0: r = 0.82; N1: r = 0.92; and N2: r = 0.96), and @entity5 size (<3 mm 3 : r = 0.76 versus >= 3 mm3: r = 0.94). CONCLUSIONS: Overexpression of @entity1476 and @entity1495 are often associated with increased invasive metastatic potential of @entity14 . However, their activities are essential during the early stages of @entity5 progression.
