An evaluation and replication of miRNAs with disease stage and XXXX -specific mortality.

@entity1 @entity29087 @entity5 @entity16105 @entity1442 @entity71367 @entity14 @entity6956 @entity694 @entity3373
UNASSIGNED: MicroRNAs (miRNAs) have been implicated in @entity14 ( @entity14 ) development and associated with prognostic indicators such as disease stage and survival. Prognostic associations are often based on few individuals and imprecise. In this study, we utilize population-based data from 1,141 @entity14 cases to replicate previously reported associations between 121 miRNAs and disease stage and survival. The Agilent @entity1 miRNA Microarray V19.0 was used to generate miRNA data following a stringent quality control protocol. Assessment of survival was done using Cox Proportional Hazard models adjusting for age, disease stage and @entity5 molecular phenotype. Five miRNAs were associated with more @entity1442 stage; @entity3373 -5p and hsa-miR-31-5p showed increased expression with more advanced @entity5 stage, while hsa-miR-200b-3p, @entity29087 and hsa-miR-451a had decreased expression with more @entity5 . Thirteen miRNAs were associated with @entity14 mortality among individuals diagnosed with @entity694 while 14 were associated with @entity14 mortality after a diagnosis with @entity5 . Strongest associations were observed for those miRNAs that were expressed in a small subset of @entity5 . Most notable associations were for @entity3373 -3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and @entity6956 (HR 10.28, 95% CI 1.31, 80.84) with @entity694 and @entity16105 -5p (HR 0.17, 95% CI 0.05, 0.54) for @entity5 . hsa-miR-374a-5p, @entity71367 and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of @entity5 site. Our findings illustrate the need for a large sample to evaluate the association of miRNAs with survival and disease stage in order to determine associations by @entity5 site.
