Neural Substrates of Auditory Emotion Recognition Deficits in XXXX .

@entity1 @entity2167 @entity73 @entity1650 @entity914 @entity72247 @entity51 @entity161
@entity2167 (AER) are a core feature of @entity161 and a key component of social @entity73 . @entity2167 are tied behaviorally to impaired ability to interpret tonal ("prosodic") features of speech that normally convey emotion, such as modulations in base pitch ( @entity72247 ) and pitch variability (F0SD). These modulations can be recreated using synthetic frequency modulated (FM) tones that mimic the prosodic contours of specific emotional stimuli. The present study investigates neural mechanisms underlying @entity1650 using a combined event-related potential/resting-state functional connectivity (rsfMRI) approach in 84 @entity161 / @entity914 @entity1 and 66 healthy comparison subjects. Mismatch negativity (MMN) to FM tones was assessed in 43 @entity1 /36 controls. rsfMRI between auditory cortex and medial temporal (insula) regions was assessed in 55 @entity1 /51 controls. The relationship between AER, MMN to FM tones, and rsfMRI was assessed in the subset who performed all assessments (14 @entity1 , 21 controls). As predicted, @entity1 showed robust reductions in MMN across FM stimulus type (p = 0.005), particularly to modulations in F0M, along with impairments in AER and FM tone discrimination. MMN source analysis indicated @entity2167 , whereas rsfMRI analyses showed reduced auditory-insula connectivity. MMN to FM tones and functional connectivity together accounted for    50% of the variance in AER performance across individuals. These findings demonstrate that impaired preattentive processing of tonal information and reduced auditory-insula connectivity are critical determinants of social @entity73 in @entity161 , and thus represent key targets for future research and clinical intervention. SIGNIFICANCE STATEMENT: @entity161 @entity1 @entity51 in the ability to infer emotion based upon tone of voice [auditory emotion recognition (AER)] that @entity73 in social cognition and global functional outcome. This study evaluated neural substrates of @entity1650 in @entity161 using a combined event-related potential/resting-state fMRI approach. @entity1 showed impaired mismatch negativity response to emotionally relevant frequency modulated tones along with impaired functional connectivity between auditory and medial temporal (anterior insula) cortex. These deficits contributed in parallel to @entity1650 and accounted for    50% of variance in AER performance. Overall, these findings demonstrate the importance of both @entity2167 and @entity1650 in the pathophysiology of social @entity73 in @entity161 .
