Responses of the normal XXXX kidney to sequential @entity63 events.

@entity1708 @entity8 @entity308 @entity63 @entity177 @entity432 @entity810 @entity1011 @entity35 @entity855
This study was undertaken to help define how one episode of @entity8 , insufficient to cause @entity810 , influences the susceptibility of the kidney to a second more severe @entity63 event. Female @entity35 underwent either 15 min of bilateral @entity432 ( @entity432 ) or sham @entity432 . They were subjected 30 min, 3.5 h, or 24 h later to 25 min of @entity432 . Renal function (GFR, BUN, @entity1011 ), histology, and @entity1708 concentrations were compared before and after the 25-min @entity63 event. Only the @entity35 with a 30-min hiatus between the 15- and 25-min bouts of @entity432 had significantly worse @entity177 than controls subjected to a single 25-min @entity63 event. Three findings were noted only in the @entity35 with increased susceptibility: tubular cell swelling and luminal membrane injury prior to 25 min of @entity432 and a relative failure of @entity855 formation immediately following 25 min of @entity432 . Susceptibility to 25 min of @entity432 did not correlate with preischemia @entity855 content. CONCLUSION: prior mild @entity63 transiently lowers renal resistance to a second @entity63 event. Normal resistance is rapidly restored once improvements in prior cell membrane injury, cell volume regulation, and cellular energetics occur. However, resistance to additional @entity63 can be normal despite persisting @entity308 in renal @entity855 content.
