Hippocampal hyperexcitability facilitates amygdala kindling in XXXX .

@entity35 @entity410 @entity1249
BACKGROUND _ OBJECTIVES: The amygdala and hippocampus are recognized as the two important structures in the brain involved in the development and control of kindled @entity410 . The study on the precise interconnection between these two regions can provide important insights into the functional anatomy of complex partial @entity410 . In this study the effect of an experimentally increased excitability in hippocampal neurons, via hippocampal kindling, on the amygdala kindling rate was investigated in @entity35 . METHODS: Animals were divided into four groups. Tripolar electrodes were implanted in the amygdala and @entity1249 region of the dorsal hippocampus of animals of Groups 1, 3 and 4. In Group 2 animals, tripolar electrodes were only implanted in the amygdala. In Group 1, one week after surgery, the @entity35 were kindled first from the hippocampus and the next day kindled by amygdala stimulation. In Groups 2 and 3, one week after surgery, @entity35 were kindled from the amygdala. Group 4 animals had a recovery period of one week plus 32 days, which was the mean of the hippocampal kindling rate in Group 1, and then were kindled from the amygdala. RESULTS: In Group 1, the amygdala kindling rate (n; number of days for which animals were stimulated before a stage 5 motor @entity410 is triggered) and @entity410 stage at day n/2 were significantly facilitated and increased respectively. There was also a significant positive correlation between hippocampal and amygdala kindling rates. INTERPRETATION _ CONCLUSION: Results obtained show that an increase in hippocampal excitability can facilitate kindling from the amygdala. Thus, it is suggested that the hippocampus has an important role in the development and propagation of @entity410 from the amygdala.
