Dominance of CD4+ alpha/beta T-cells and inferior role of innate immune reaction in liver XXXX .

@entity1 @entity5 @entity3
BACKGROUND: Tumor infiltrating lymphocytes (TIL) are frequently present in @entity1 @entity5 with CD8+(-)T-cells as effector and CD4+ T-cells as helper cells. Despite the well established knowledge about @entity5 , only little is known about metastatic disease, especially for liver @entity3 . The role of the innate immune system in the @entity5 defence is still enigmatic. MATERIALS AND METHODS: We performed a subtyping of TIL in 20 liver @entity3 . Using immunohistochemistry, CD20+, CD3+, CD56+, CD4+ and CD8+ lymphocytes, gamma/delta-T-cells and alpha/beta-T-cells in the @entity5 , the peritumoral region, portal tracts and lobules were investigated. RESULTS: The immune response was highly accentuated in the surroundings of the @entity3 with only few lymphocytes in the @entity5 itself. There was a dominance of CD3+(-)CD4+(-)alpha/beta-T-cells with a lower number of CD8+(-)T-cells. The CD4+/CD8+ ratio was 6:1. CD56+(-)NK/NKT-cells and gamma/delta-T-cells were rare. No differences were found between @entity3 from different primaries or according to the number or diameter of the @entity3 . CONCLUSION: TIL are part of an interaction between the @entity3 and the liver. Among them CD4+ T-cells seem to have a unique independent function in @entity5 response. The localization of the immune response in the @entity5 periphery might be a reason for insufficient @entity5 defense. A defect in the innate immune system could be a reason for the escape of the @entity3 cells from @entity5 surveillance.
