XXXX of the residual small intestine after partial enterectomy. A neurohumoral feedback?

@entity1184 @entity1707 @entity2270 @entity7298
Experiments were designed to test, using 76 @entity1707 , 1) whether a humoral factor inducing @entity1184 is released after partial enterectomy or not, and 2) whether visceral sensitivity conducted to the central nervous system by the route of the vagus plays a role in the @entity1184 or not. Vascular parabiosis was established between @entity1707 paired for an identical blood group and histocompatibility. A continuous blood cross circulation was maintained for 410 h either between two normal @entity1707 or between a normal and a jejunectomized (30 per cent) @entity1707 . Their growth and food intake, and the tissue weight of their small intestine were checked. Both the jejunectomized @entity1707 and their unoperated partners showed a significant @entity1184 of the small intestine, whether residual or intact, as compared to intact @entity1707 cross circulated between them. The @entity1184 observed in the unoperated partners of the jejunectomized @entity1707 was not the result of any @entity7298 . There was thus a true humoral mediation of the @entity1184 . Vagal deafferentation, i.e. a selective surgical suppression of the vagal afferent (sensory) pathways originating below the diaphragm, was performed in jejunectomized @entity1707 . Their performances and small intestine morphology (whole tissue weight and dry weight of the mucosa) were compared to those measured in jejunectomized but vagally intact @entity1707 . The dry weight of the mucosa of the residual small intestine in resected @entity1707 was restored (after 28 days) at a value similar to that measured for the intact small intestine in controls. Opposite to that, the dry weight of the mucosa of the residual intestine of resected + deafferented @entity1707 was significantly lower, due to the absence of any @entity1184 . This difference did not result from any change in the food intake level. Therefore it was concluded that vagal afferences from the digestive tract are necessary in eliciting the @entity1184 . From these results and some recent bibliographical data, it is tentatively concluded that @entity1184 of the residual small intestine after partial enterectomy might be mediated through a neuro-humoral feedback whose afferent way would be the vagal sensory pathway, and efferent way would be a hormonal one monitored by the hypothalamo-hypophyseal @entity2270 .
