The effect of @entity3724 on insulin sensitivity and plasma lipid profile in non-diabetic males with low high XXXX .

@entity1 @entity3724 @entity6 @entity1674 @entity412 @entity751 @entity2101 @entity1720 @entity413 @entity165
@entity6 , particularly those with very low levels of high density lipoprotein (HDL) type @entity165 and high levels of very low density type lipoprotein (VLDL), are associated with insulin resistance and @entity1720 . The evidence that elevation of HDL @entity165 and diminution of @entity1674 with drugs, with improvement in insulin sensitivity is still lacking. In the treatment of the @entity751 with hypolipidaemic drugs, the associated metabolic abnormality of insulin resistance/sensitivity has to be addressed. We investigated the degree of @entity1720 in 23 @entity1 with low HDL and/or raised @entity1674 by measuring the fasting, first and second hour insulin levels during an oral @entity413 tolerance test (OGTT) and repeated the measurements after a 6-month course of @entity3724 . The insulin levels were correlated with the OGTT, blood pressure, total @entity165 , HDL @entity165 , LDL @entity165 , and @entity1674 measured before and at the end of the trial. The serum insulin at the second hour of the OGTT fell from 100.79 +/- 42.79 mU/l to 54.56 +/- 25.43 mU/l (P < 0.0005) even though there was no change in the blood @entity413 level at this point. Our study shows that @entity3724 ( @entity3724 ) 300 mg daily significantly raises the pretreatment low HDL @entity165 (from 0.64 +/- 0.1 mmol/l to 0.99 +/- 0.2 mmol/l) as well as lowers the @entity412 level (from 2.17 +/- 1.1 mmol/l to 1.43 +/- 0.64 mmol/l) in @entity1 with @entity2101 . The data also support the conclusion that treatment with @entity3724 @entity1720 as measured by the corresponding insulin levels of the OGTT in the study subjects who presented with very low HDL @entity165 level. There was also a decrease in blood pressure readings in our study subjects. Throughout the trial, there was no significant change in body weight or exercise level in the subjects studied.
