Preserved incretin effect after complete surgical denervation of the pancreas in young XXXX .

@entity1707 @entity11938 @entity72659 @entity413
Plasma @entity11938 responses to intragastric (i.g.) (1.5 g/kg b.wt.) and "isoglycemic" intravenous (i.v.) @entity413 were measured in ten unanesthetized young @entity1707 to assess the contribution of gastrointestinal factors to the total @entity11938 secretion as observed after i.g. @entity413 . The participation of nerves was estimated by comparing metabolic tests performed before and after total surgical pancreatic denervation. In the five animals which survived the procedure, 52.6% of the @entity11938 response after i.g. @entity413 was calculated to be due to incretion factors, a value similar to the 54.8% found in the preoperative series (with intact pancreatic innervation). The response of IR- @entity72659 to i.g. @entity413 was not significantly different between preoperative and postoperative tests, although a subtotal duodenectomy had to be performed in the course of the operation designed to completely denervate the pancreas. Intragastric and i.v. (also tested by bolus @entity413 injection) @entity413 tolerance was almost identical before and after the operation. It was concluded that nerves do not seem to play a major role in mediating the incretin effect in @entity1707 . Hormonal factors, including @entity72659 , appear to be more important.
