Prognostic value of biochemical markers of brain damage and oxidative stress in post-surgical XXXX @entity1 .

@entity1 @entity510 @entity4483 @entity538 @entity1234 @entity439 @entity3508 @entity1865
The aim of this study is to determine effective biochemical markers and optimal sampling timing for prediction of neurological prognosis in post-surgical @entity510 ( @entity510 ) @entity1 . Subjects were a sequential group of @entity510 @entity1 admitted to our centre who underwent @entity439 clipping before Day 3 and who received a cerebrospinal fluid (CSF) drain. CSF samples from 32 @entity1 were collected on Days 3, 7, and 14. Neurological outcome was assessed by neurosurgeons using the Glasgow outcome scale (GOS) at 6 months after onset. CSF levels of @entity3508 ( @entity3508 ), @entity4483 , and @entity538 ( @entity538 ) were determined using enzyme-linked immunosorbent assay, and the CSF concentrations of @entity1234 ( @entity1865 ) were determined using spectrophotometric assay. In univariate analysis, @entity4483 on Days 3 and 14, @entity538 on Days 3 and 7, and @entity1865 on Day 14 were significantly higher in the poor outcome group (GOS 1-4) than in the good outcome group (GOS 5). In multivariate analysis, only @entity1865 on Day 14 was identified as a significant predictor of poor neurological outcome at 6 months after onset. The area under the receiver-operating characteristic (ROC) curve for @entity1865 on Day 14 was 0.841. For a threshold of 0.3 microM, sensitivity and specificity were 0.875 and 0.750, respectively. Our findings suggest that these biochemical markers, especially @entity1865 , show significant promise as predictors of neurological outcome in clinical practice.
