Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined XXXX / @entity588 and MYC rearrangement.

@entity1 @entity10730 @entity981 @entity588 @entity1075 @entity706 @entity2225 @entity2282 @entity1892 @entity2280 @entity7513
BACKGROUND: @entity981 ( @entity981 ) with combined @entity7513 / @entity588 and MYC rearrangement are rare and their clinical, cytogenetic and immunophenotypic features are not well characterized. Here, we describe a case of a 61-year-old @entity1 with @entity981 associated with these cytogenetic alterations and present a review of the literature of this disease. METHODS: Four-color flow cytometry (FC) was performed on a BD FACSCanto II flow cytometer. Data were analyzed with BD FACSDiva software. Cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies were performed by conventional methods. A review of the literature was performed by a PubMed-assisted search. RESULTS: Including our case, eight B-LBLs associated with a documented "double-hit" karyotype ( @entity7513 / @entity588 and 8q24/MYC rearrangement) were identified in the literature (male/female 2/6, age 15-65). Three occurred de-novo, and five had a history of a @entity2282 + @entity1892 . The typical immunophenotype was @entity2282 , @entity1075 , @entity10730 positive, and negative for @entity2280 and surface immunoglobulin (Ig), established either by flow cytometry or immunohistochemistry. Seven cases were @entity2225 -, and one case was @entity2225 +. Translocation partners of MYC varied, and included @entity7513 , lambda light chain, and an unknown gene on chromosome 9. Prognosis was poor with median survival of five months. CONCLUSIONS: @entity1 with @entity981 associated with a combined @entity7513 / @entity588 and MYC rearrangement often have a history of a mature @entity1892 . The immunophenotype of these cases is different from that of mature "double-hit" @entity706 ; FC is essential to differentiate the @entity981 cases from the leukemic phase of mature @entity1892 . This article is protected by copyright. All rights reserved.
