Adaptations in lipid metabolism of XXXX adipose tissue in lactogenesis and lactation.

@entity844 @entity1425 @entity653 @entity2922 @entity1063 @entity291
The timing and magnitude of metabolic adaptations in adipose tissue during lactogenesis and lactation were determined in first lactation @entity291 . In vitro rates of lipogenesis and palmitate esterification were measured to estimate in vivo synthesis. Lipolysis was measured in the basal state and as maximally stimulated by @entity1063 or @entity1425 to estimate physiological adaptations as well as the changes in @entity2922 responsiveness. Subcutaneous adipose tissue was biopsied at -1, -0.5, +0.5, 1, 2, and 6 months from parturition. From 1 to 0.5 months prepartum there was a 54% reduction in lipogenesis, a 16% reduction in esterification, a 54 and 77% increase in @entity1063 - and @entity1425 -stimulated free @entity844 (FFA) release, respectively, and a 28% increase in @entity1425 -stimulated @entity653 release. The immediate postpartum period (0.5 and 1 month) was marked by a decrease in lipogenesis to 5% and esterification to 50% of -1 month rates. During this period, @entity1063 -stimulated FFA release increased 50% above -1 month rates, @entity1425 -stimulated FFA release increased 128%, and @entity1063 - and @entity1425 -stimulated @entity653 release increased 30 and 87%, respectively. Midlactation (2 and 6 months) was marked by a dramatic rebound in lipogenesis and esterification to 14-fold and 2.5-fold prepartum rates, respectively. Basal @entity653 release doubled during this period, while basal FFA release declined to near prepartum levels. @entity2922 -stimulated FFA and @entity653 release decreased from the peak during midlactation, but remained elevated compared to prepartum levels.(ABSTRACT TRUNCATED AT 250 WORDS)
