XXXX : outcomes of preoperative endosonography-guided fine needle aspiration, and recurrence during long-term follow-up.

@entity1 @entity6196 @entity788 @entity7582 @entity5 @entity787 @entity3
UNASSIGNED: Background and study aims: The role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the diagnosis and management of @entity788 (PNETs) is unclear. We aimed to compare clinical/endosonographic characteristics of cystic with solid PNETs, determine diagnostic accuracy of preoperative EUS-FNA, and evaluate recurrence rates after resection. @entity1 and methods: All @entity1 with cystic or solid @entity6196 confirmed by EUS-FNA between 2000 and 2014 were identified. A matched case-control study compared 50 consecutive @entity1 with cystic PNETs with 50 consecutive @entity1 with solid PNETs, matched by gender and age at diagnosis of index cystic @entity6196 . We compared clinical/endosonographic characteristics, assessed diagnostic accuracy of preoperative EUS-FNA for identifying @entity5 , and analyzed @entity5 -free survival of @entity1 with cystic and solid PNETs. Results: @entity788 tended to be larger than solid PNETs (mean 26.8 vs. 20.1mm, P=0.05), more frequently nonfunctional (96% vs. 80%, P=0.03), and less frequently associated with @entity7582 (10% vs. 28%, P=0.04). With surgical pathology as reference standard, EUS-FNA accuracies for @entity5 of cystic and solid PNETs were 89.3% and 90%, respectively; cystic PNETs were less associated with metastatic adenopathy (22% vs. 42%, P=0.03) and liver @entity3 (0% vs. 26%, P<0.001). Cystic fluid analysis (n=13), showed benign cystic PNETs had low @entity787 ( @entity787 ), Ki-67 <=2%, and no loss of heterozygosity. @entity1 with cystic and solid PNETs had similar recurrence risk up to 5 years after complete resection. Conclusions: @entity788 have distinct clinical and EUS characteristics, but were associated with less aggressive biological behavior compared with solid PNETs. EUS-FNA is accurate for determining malignant potential on preoperative evaluation. Despite complete resection, recurrence is observed up to 5 years following surgery.
