Hormonal prevention of XXXX .

@entity251 @entity263 @entity586 @entity585 @entity10831 @entity342 @entity4383
@entity263 is disease in which the mortality rate is highly variable among populations. An increasing risk with migratory changes suggests that some environmental factor or factors influence @entity263 risk. It is well established that the prostate is hormonally influenced. Carcinogenesis is a process of malignant transformation evolving over time, involving cellular growth and division. There is evidence suggesting that androgenic influences over a period time encourages the process of prostate carcinogenesis. Studies of prostate biology support the concept that @entity586 is the principal @entity342 responsible for both normal and hyperplastic growth of the prostate gland. It may be that @entity342 causes prostate carcinogenesis. Suppression of @entity586 synthesis may inhibit @entity4383 . Some preclinical and clinical observations support this hypothesis. A placebo controlled randomized trial using @entity585 , an inhibitor of @entity10831 , the enzyme that converts @entity251 to @entity586 , is ongoing. The endpoint of this trial is reduction of @entity263 incidence.
