Chemotherapy for XXXX given during pregnancy: A case serie.

@entity1 @entity2208 @entity0 @entity5948 @entity649 @entity600
UNASSIGNED: 715 Background: Experience with chemotherapy for @entity0 during pregnancy is limited. This retrospective case series presents the accumulated experience of four London hospitals in giving chemotherapy to 28 pregnant @entity1 with @entity0 . This represents one of the largest series of such @entity1 to date. METHODS: A retrospective case note review was performed at four London hospitals to identify @entity1 who received chemotherapy for @entity0 whilst pregnant. RESULTS: Twenty-eight @entity1 were identified who had received chemotherapy for @entity0 whilst pregnant, with stage I (2), stage II (11), stage III (11) and stage IV disease (4). The mean maternal age at diagnosis was 34 years (range 28-42), the mean gestational age at diagnosis was 17 weeks (range 4-33). Seventeen @entity1 underwent surgery whilst pregnant, at a mean gestational age of 16 weeks (range 5-29). Chemotherapy was given in the adjuvant (17), neoadjuvant (7) and palliative settings (4). Sixteen @entity1 received @entity5948 -based chemotherapy, and 12 CMF. One @entity1 was treated in the first trimester, but had a @entity2208 . The remaining 27 @entity1 were treated in the second and third trimesters, commencing at a mean gestational age of 22.7 weeks (range 15-33). A total of 116 cycles of chemotherapy were given, with a median of 4 cycles during pregnancy (range 1-6). Chemotherapy was well tolerated at full doses without major complications. The mean gestational age at delivery was 37 weeks (range 30-40). No @entity600 were reported, and the mean birth weight of the @entity1 was 2.9kg (range 1.4 to 3.5). Two of the newborns experienced @entity649 and a total of 5 required transfer to a specialised neonatal unit, but all made full recoveries. CONCLUSIONS: In terms of peri-partum complications and immediate fetal outcome, chemotherapy can be safely administered to @entity1 with @entity0 in the second and third trimesters of pregnancy. No significant financial relationships to disclose.
