[ XXXX : clinical and pathomorphological restructurings after surgical treatment of @entity449 .]

@entity1 @entity449 @entity1614 @entity439 @entity337 @entity397 @entity472
UNASSIGNED: The authors examined the state of @entity1 suffering from @entity1614 ( @entity1614 ) who endured operation for ascending @entity439 with replacement of the ascending aorta and aortic valve (Bentall operation), studying alterations of the skeleton, face, heart and eyes, as well as pathomorphological restructurings in the aortic wall. The study was carried out 7.0  4.2 years after the operation. We examined a total of 39 @entity1 with @entity1614 - 27 (69.2%) @entity1 and 12 (30.8%) @entity1 aged from 22 to 70 years old (average age - 42.1  13.4 years). All @entity1 were operated on for dissecting @entity439 of the ascending aorta accompanied by a considerable degree of @entity337 or @entity472 . The mean diameter of the aorta at the level of the sinuses of Valsalva amounted to 7.0  1.3 cm (minimal - 5.0 cm, maximal - 12.0 cm), the Z-score prior to operation was 12.7  6.5. The time form making the diagnosis of @entity1614 to surgical intervention for @entity449 amounted to 9.6  5.9 years. The condition after operative treatment in all @entity1 was satisfactory, with the haemodynamic indices stable: systolic AP - 133.5  19.1 mm Hg, diastolic AP 85.1  12.9 mm Hg, heart rate 74.8  7.2 bpm. The average systemic score for the symptoms and tests of @entity1614 @entity1 amounted to 8.2  3.3 points. Pathohistological alterations of the aorta in @entity1 with @entity1614 consisted in pronounced restructuring of the wall with deep irreversible alternative changes. The pathological process extended in the middle aortic layer all alone the length, but not only in the portions of @entity397 and dissection. The main pathomorphological signs in @entity1614 were as follows: focal accumulations of mucoid substances, dystrophic alterations of smooth-muscle cells, ribbon-like anuclear zones, formation of cystlike cavities, alterations of elastic fibres - fragmentation, hyperelastosis, multiplication, thinning and straightening, zones of elastolysis.
