Type 1 @entity6 Is Associated With an Increased Risk of @entity174 Across the Life Span: A Population-Based Cohort Study Using XXXX ( @entity283 ).

@entity1 @entity174 @entity283 @entity6 @entity173
OBJECTIVE: This study was conducted to determine if type 1 @entity6 is associated with an increased risk of @entity174 across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from @entity283 ( @entity283 ) in the U.K. (data from 1994 to 2012), in which 30,394 @entity1 aged 0-89 years with type 1 @entity6 were compared with 303,872 randomly selected age-, sex-, and practice-matched @entity1 without @entity6 . Cox regression analysis was used to determine hazard ratios (HRs) for incident @entity174 in @entity1 with type 1 @entity6 . RESULTS: A total of 334,266 @entity1 , median age 34 years, were monitored for 1.9 million @entity1 -years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in @entity1 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in @entity1 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity @entity174 comprised a higher proportion of incident @entity174 in @entity1 with versus those without type 1 @entity6 (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident @entity173 identified the highest HR of 5.64 (95% CI 3.55-8.97) in @entity1 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in @entity1 30-39 years. CONCLUSIONS: Type 1 @entity6 was associated with increased risk of incident @entity174 that began in childhood and extended across the life span. @entity1 with type 1 @entity6 sustained a disproportionately greater number of lower extremity @entity174 . These findings have important public health implications, given the increasing prevalence of type 1 @entity6 and the morbidity and mortality associated with @entity173 .
