Alterations in XXXX Receptor and @entity29022 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration.

@entity1 @entity162 @entity2000 @entity3264 @entity29022 @entity19 @entity1713 @entity10092 @entity4176 @entity72645 @entity528
@entity528 differentially impacts glutamatergic signaling in downstream On and Off @entity162 . In rodent models, @entity528 leads to loss of glutamatergic signaling in On @entity162 , whereas Off @entity162 appear to retain @entity3264 sensitivity, even after extensive photoreceptor loss. The localization and identity of the receptors that mediate these residual @entity3264 responses in Off @entity162 have not been determined. Recent studies show that macaque and @entity19 Off @entity162 receive glutamatergic input primarily through @entity4176 -type @entity3264 receptors. Here, we studied the impact of @entity528 on @entity3264 receptor and their associated proteins in Off and On @entity162 . We show that the @entity4176 receptor subunit, @entity10092 , persists in remodeled Off bipolar cell dendrites of the rd10 @entity19 retina. However, the pattern of expression is altered and the intensity of staining is reduced compared to wild-type retina. The @entity4176 receptor auxiliary subunit, @entity72645 , also remains in Off bipolar cell dendrites after extensive @entity528 . Similar preservation of @entity4176 receptor subunits was evident in @entity1 retina in which photoreceptors had degenerated due to @entity1713 . In contrast, @entity528 leads to loss of synaptic expression of @entity29022 in @entity19 and @entity1 On @entity162 , but strong somatic expression remains. These findings demonstrate that Off @entity162 retain dendritic @entity3264 receptors during @entity2000 and could thus serve as a conduit for signal transmission from transplanted or optogenetically restored photoreceptors.
