[Clinicopathological analysis of loss of fragile @entity3793 triad expression in XXXX ].

@entity1 @entity3793 @entity1792 @entity5 @entity2 @entity406 @entity1149 @entity1600 @entity957 @entity420 @entity982 @entity21900
BACKGROUND: To investigate the relationship between expression of fragile @entity3793 triad gene protein, @entity21900 , and clinicopathological characteristics of @entity1 @entity2 . METHODS: @entity21900 protein expression was detected in 92 cases of @entity406 -fixed, @entity982 -embedded @entity1 @entity2 by @entity1792 -microwave-SP immunohistochemical method, of which 52 were @entity1149 ( @entity1149 ) and 40 @entity5 ( @entity5 ). Its relationship to histological grade, @entity1600 and histological classification were analysed. RESULTS: The loss of @entity21900 protein expression were found in 62.0% (57/92) and 4.3% (4/92) of @entity5 tissue and normal lung tissue, respectively and there was a significant difference in the expression of @entity21900 protein between @entity5 and normal tissue (P=0.000). 53.8% (28/52) of the cases of @entity1149 showed a marked loss or absence of @entity21900 expression, 46.2% (24/52) of cases were negative, 7.7% (4/52) showed a higher expression and 38.5% (20/52) equal to the level of @entity21900 expression compared with the matched normal tissues. The loss of @entity21900 expression was closely related to histological grade (P=0.003), to @entity1600 (P=0.029), and to histological classification of the cases (P=0.003). There was a significant difference between grade I+II (38.2%; 13/34) and @entity5 (83.3%; 15/18), between @entity5 with @entity1600 (70.8%; 17/24) and those without (39.3%; 11/28), and between @entity957 ( 68.6%; 24/35) and @entity420 (23.5%; 4/17). The loss of @entity21900 protein expression was found in 33 of 40 cases of @entity5 (82.5%) and the remainder 7 cases (17.5%) showed the same quantity of expression of @entity21900 , compared with the normal bronchial mucosa. CONCLUSIONS: The expression of @entity21900 protein may be associated with the decreasing differentiation, @entity1600 and histological classification in @entity1149 , and be corresponding to the occurrence and evolution of @entity5 . These results suggest that the decreased @entity21900 expression plays an important role in the development and progression of the @entity5 , and thus may become a new prognostic marker in @entity1 @entity2 .
