Is late antibiotic prophylaxis effective in the prevention of secondary XXXX ?

@entity1 @entity788 @entity7362 @entity656 @entity2177 @entity2889 @entity35 @entity204
BACKGROUND: Secondary infection of the inflamed pancreas is the principal cause of @entity204 after severe acute @entity788 (AP). Although @entity1 are not always managed early in the course of AP in clinical practice, prophylactic antibiotics that were used in experimental studies in @entity35 were always initiated early after induction of @entity788 . The effectiveness of antibiotics initiated later is unknown. AIM: The aim of this study was to compare the effectiveness of @entity2177 and @entity2889 initiated early versus later in the course of @entity656 ( @entity656 ) in @entity35 . METHODS: 100 @entity35 were studied. @entity656 was induced in @entity35 by intraductal injection of 3% @entity7362 . @entity35 were divided randomly into five groups: group I @entity35 received normal saline as a placebo, group II and IV @entity35 received three times daily @entity2889 60 mg/kg i.p. at 2 and 24 h, respectively and group III and V @entity35 received twice daily @entity2177 50 mg/kg i.p. at 2 and 24 h, respectively, after induction. At 96 h, all @entity35 were killed for quantitative bacteriologic study. A point-scoring system of histological features was used to evaluate the severity of @entity788 . RESULTS: @entity2889 and @entity2177 initiated 2 h after induction of @entity788 significantly reduced the prevalence of @entity788 (p < 0.001 and p < 0.04, respectively) as compared to controls. Neither of the antibiotics initiated later during the course of AP caused a significant decrease in @entity788 in @entity35 (p > 0.05). Although the @entity35 treated early infected less frequently than the @entity35 treated later, the comparison reached statistical significance only in the @entity2889 group (p < 0.02). CONCLUSION: Early antibiotic treatment reduces @entity788 more efficiently than late antibiotic treatment in @entity656 in @entity35 .
