XXXX due to group B streptococci--perinatal risk factors and outcome of subsequent pregnancies.

@entity1 @entity295 @entity883 @entity397
All cases of early onset @entity883 ( @entity883 ) @entity295 in @entity1 born at Karolinska Hospital 1975-1986 were reviewed. @entity883 was diagnosed in 40 @entity1 within the first five days of life. The incidence was 1.24 per 1000 births. Fifty-five percent of the @entity1 were preterm and 48% were born more than or equal to 12 hours after @entity397 . Prematurity and/or prolonged @entity397 were present in 83% of all neonates with fatal outcome. Case fatality was 22%. Deliveries by both cesarean section (31%) and vacuum extraction (26%) were increased in the mothers when compared to an overall incidence of 14 and 12% (p less than 0.01). Twenty-four (89%) of 27 mothers had low type specific IgG antibodies against the infecting @entity883 -serotype. Late onset @entity883 was diagnosed in only two @entity1 during the period. Seventeen mothers went through 24 subsequent pregnancies. In 11 of those the mothers were colonized with @entity883 and 10 received penicillin prophylaxis during pregnancy and/or delivery. None of the @entity1 born after prophylaxis were colonized with @entity883 . Two were born prematurely and all had an uneventful course; whereas one @entity1 delivered at 26 weeks gestation of a colonized untreated mother died of @entity883 . Screening of parturients at risk and selective antibiotic prophylaxis may help to prevent early onset @entity883 .
