The @entity164 2 @entity6 -associated variant in XXXX is associated with latent autoimmune @entity6 in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study.

@entity1 @entity6 @entity12011 @entity8406 @entity8405 @entity164
AIMS/HYPOTHESIS: The variants of @entity8405 ( @entity8405 ) gene have been proposed to be associated with @entity12011 ( @entity12011 ). We sought to confirm the possible association in Europeans and to examine the interaction between one gene variant and clinical data. METHODS: The @entity8405 @entity8406 C-to-T polymorphism was genotyped in 211 @entity12011 , 1,297 @entity164 2 @entity6 , 545 @entity164 1 @entity6 and 1,497 control individuals from Hungary. A meta-analysis of our and previously published studies was performed to evaluate the size and the heterogeneity of the gene effect. RESULTS: The meta-analysis yielded a significant effect of @entity8405 T allele (OR 1.28; p < 0.0001) on @entity12011 risk without heterogeneity among Europeans. The T allele conferred equally strong susceptibility to @entity12011 and @entity164 2 @entity6 . In the Hungarian dataset, the T allele was associated with @entity12011 and @entity164 2 @entity6 , but not with @entity164 1 @entity6 . T allele carriers had significantly lower BMI than @entity1 with the CC genotype in the @entity12011 and @entity164 2 @entity6 groups (p = 0.0021 and p = 0.0013, respectively). In both diseases, the @entity6 risk was significantly higher in the non-overweight than in the overweight BMI category (p = 0.0013 and p < 0.0001, respectively); susceptibility to @entity12011 was increased by 2.84-fold in non-overweight individuals compared with overweight ones. CONCLUSIONS/INTERPRETATION: The meta-analysis demonstrates that @entity8405 @entity8406 polymorphism is a population-independent susceptibility locus for @entity12011 in Europeans. The effect size is similar for @entity12011 and @entity164 2 @entity6 . The gene effect on @entity6 risk may be modulated by BMI, such that the lower the BMI, the higher the gene effect.
