Effect of @entity1 Wharton's jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of XXXX cells.

@entity1 @entity632 @entity1603 @entity5 @entity4404 @entity2 @entity792
Multipotent mesenchymal stem cells (MSCs) are recently found to alter the @entity5 condition. However their exact role in @entity5 development is not yet fully unraveled. MSCs were established to perform many of their actions through paracrine effect. Thus investigation of MSC secretome interaction with @entity5 cells may provide important information for scientists who are attempting to apply stem cells in the treatment of the disease. In this study we investigated the effect of @entity1 Wharton's jelly derived MSC (WJ-MSCs) secretome on proliferation, apoptotic potential of A549 @entity2 cells, and their response to the chemotherapeutic agent @entity632 . WJ-MSCs were isolated from @entity1 umbilical cord and then characterized according to the International Society for Cellular Therapy criteria and WJ-MSC secretome was collected. @entity1603 cell proliferation assay and @entity4404 -PI staining were used for the evaluation of cytotoxic and proapoptotic effects of WJ-MSC secretome on A549 cells. WJ-MSC secretome neither induced @entity2 cells nor affected the apoptotic potential of the @entity5 cells. We also studied the combinatorial effect of WJ-MSC secretome and the anticancer drug doxorubicinwhich showed no induction of drug resistance when A549 cells was treated with combination of WJ-MSC secretome and @entity632 . Although MSCs did not show antitumor properties, our in vitro results showed that MSC secretome was not tumorigenic and also did not make @entity2 cells resistant to @entity632 . Thus MSC secretome could be considered safe for other medical purposes such as cardiovascular, neurodegenerative, and @entity792 which may exist or occur in @entity5 @entity1 .
