Weekly XXXX therapy compared with triweekly combination chemotherapy as concurrent adjuvant chemoradiation therapy after radical hysterectomy for @entity5 .

@entity1 @entity137 @entity417 @entity882 @entity5 @entity900 @entity3846 @entity1398 @entity1431
OBJECTIVE: To evaluate whether the use of triweekly combination chemotherapy together with radiation exerts a more beneficial systemic effect than weekly @entity900 chemoradiation in @entity1 with @entity5 after radical surgery. METHODS: We retrospectively analyzed @entity1 with stage @entity3846 to @entity5 who had undergone radical hysterectomy with pelvic lymph node dissection, followed by concurrent adjuvant chemoradiation therapy. The @entity1 were divided into 2 groups: the triweekly combination chemotherapy group and the weekly @entity900 chemotherapy group. We evaluated the survival and adverse effects of the 2 groups. RESULTS: In total, 201 @entity1 were included. The mean duration of follow-up was 52.2 months. Of the 201 @entity1 , 130 received triweekly combination chemotherapy, and 71 @entity1 received weekly @entity900 chemotherapy as an adjuvant treatment. The 5-year disease-free survival was 82.2% for @entity1 treated with weekly @entity900 chemotherapy and 74.3% for those treated with triweekly combination chemotherapy (P = 0.3929). The 5-year overall survival was 81.4% and 79.3% for the same treatment groups, respectively (P = 0.9833). The overall survival of the @entity1 with @entity5 was marginally higher in the triweekly combination chemotherapy group than in the weekly @entity900 group (P = 0.0582). @entity1431 , @entity1398 , @entity882 , @entity417 , and hepatopathy were significantly more common in the triweekly combination chemotherapy group. CONCLUSIONS: The weekly @entity900 chemotherapy group experienced the same therapeutic effect as the triweekly combination chemotherapy group but with less @entity137 . Therefore, weekly @entity900 chemotherapy is considered the more useful concurrent adjuvant chemoradiation regimen after radical surgery.
