The interplay of the gut microbiome, XXXX , and volatile organic compounds.

@entity32 @entity14646 @entity344 @entity6636 @entity6741 @entity3645
Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut @entity6636 in @entity344 . Gut @entity6636 occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of @entity3645 (BA) in the gut. BA metabolites as a result of microbial transformations act as signaling molecules and have demonstrated regulation of intestinal homeostasis through the @entity14646 and FXR receptors by inhibiting @entity32 , preventing pathogen invasion, and maintaining cell integrity. The presence of VOC footprints is the resultant effect to gut microbiome substrate fermentation. Aim. To review the role of the gut microbiome and @entity6741 signaling in intestinal homeostasis and the resultant use of VOCs as potential noninvasive surrogate biomarkers in gut @entity6636 . Methods. A systematic search on PubMed and Medline databases was performed to identify articles relevant to gut @entity6636 , BA metabolism, and VOCs. Conclusions. The host and presence of the gut microbiome appear to regulate the BA pool size. A dysbiotic gut microbiome results in disrupted intestinal homeostasis, which may be reflected by VOCs, differentiating those who are healthy and those with disease.
