Prognostic relevance of pathologic subtypes and minimal invasion in XXXX of the pancreas.

@entity1377 @entity4929 @entity189 @entity4056 @entity19354 @entity652 @entity204 @entity356
Intraductal @entity4929 (IPMNs) of the pancreas are classified into the following four histopathologic subtypes: gastric, intestinal, pancreatobiliary, and oncocytic. However, the clinicopathologic characteristics of IPMN subtypes have not been fully clarified. Recently, a subgroup classification of @entity1377 ( @entity1377 ) was suggested in contrast to overt @entity189 from IPMCs (IC-IPMCs). The purpose of this study was to determine whether or not the pathologic subtype classification can predict prognosis and to validate the usefulness of the newly proposed diagnostic criteria of @entity1377 . We reviewed the clinicopathologic characteristics of 142 surgically resected cases of IPMNs. There were 54, 56, 30, and two cases of the gastric, intestinal, pancreatobiliary, and oncocytic types of IPMNs, respectively. The intestinal and pancreatobiliary types were more likely to have a main duct type. All @entity356 were @entity652 or @entity19354 , whereas greater than one half of the @entity4056 in situ or invasive @entity189 . A significant difference in recurrence and @entity204 rate was noted for @entity189 between the intestinal and pancreatobiliary types. The majority of @entity1377 were the intestinal type, whereas the majority of IC-IPMCs were the pancreatobiliary type. The IC-IPMC group showed a decreased recurrence-free and overall survival with statistically significance (p < 0.001 and p = 0.001, respectively). Our results suggest that the pathologic subtype classification and the newly proposed diagnostic criteria for minimal invasion may also be useful to predict prognosis of IPMNs of the pancreas.
