Altered levels of n-6/n-3 @entity1718 in XXXX heart and storage fat following variable dietary intake of @entity4722 .

@entity844 @entity3106 @entity3952 @entity4600 @entity6298 @entity2434 @entity1474 @entity3633 @entity35 @entity1718 @entity4722
Fat-supplemented dies enriched with @entity4722 by the addition of 12% w/w sunflower seed oil or proportionally reduced in @entity4722 by addition of 12% mutton fat were fed to @entity35 for 18 months before the @entity844 composition of perirenal storage fat and myocardial membranes (phospholipids) was determined. Although the @entity844 composition of perirenal fat generally reflected that of the diet, there was an inverse relationship between the consumption of n-6 and the deposition of n-9 @entity1718 . In addition, enhanced deposition of @entity3952 (18:1, n-9) appears to be related to the dietary intake of @entity3106 (18:0). In contrast, in myocardial membranes the n-3 @entity1474 are found to be increased when the intake of n-6 @entity1474 is reduced. This is particularly evident for @entity4600 (22:6, n-3) which is significantly increased in @entity2434 , @entity3633 , and @entity6298 fractions of myocardial membranes, when the mutton fat diet was fed. After feeding the sunflower seed oil diet, the increased consumption of @entity4722 produced only small changes in the 18:2, n-6 content of cardiac @entity2434 and @entity3633 . These major classes of membrane phospholipids also showed only small increases in 20:4, n-6. In @entity6298 , increased 18:2, n-6 also followed increased dietary intake, but this was not accompanied by increased 20:4, n-6. These changes in myocardial phospholipid @entity844 composition are similar to those observed after short-term feeding reported previously and confirm that changes in dietary n-6/n-3 @entity844 intake affect the @entity844 composition of both myocardial membranes and storage fat. These changes persist for the duration of the feeding period.
