Repeatability and variability of myocardial perfusion imaging techniques in XXXX : Comparison of arterial spin labeling and first-pass contrast-enhanced MRI.

@entity296 @entity19 @entity1188 @entity583 @entity65
PURPOSE: Preclinical imaging of @entity296 ( @entity296 ) can elucidate molecular mechanisms underlying @entity65 . We compared the repeatability and variability of two methods, first-pass MRI and arterial spin labeling (ASL), for imaging @entity296 in @entity19 . METHODS: Quantitative perfusion MRI in @entity19 was performed using both methods at rest, with a vasodilator, and one day after @entity583 . Image quality (score of 1-5; 5 best), between-session coefficient of variability (CVbs ), intra-user coefficient of variability (CVintra-user ), and inter-user coefficient of variability (CVinter-user ) were assessed. Acquisition time was 1-2 min for first-pass MRI and approximately 40 min for ASL. RESULTS: Image quality was higher for ASL (3.94        0.09 versus 2.88        0.10; P   <   0.05). Infarct zone CVbs was lower with first-pass (17        3% versus 46        9%; P   <   0.05). The stress perfusion CVintra-user was lower for ASL (3        1% versus 14        3%; P   <   0.05). The stress perfusion CVinter-user was lower for ASL (4        1% versus 17        4%; P   <   0.05). CONCLUSION: For low @entity296 conditions such as @entity1188 , first-pass MRI is preferred due to better repeatability and variability. At high @entity296 such as at vasodilation, ASL may be more suitable due to superior image quality and lower user variability. First-pass MRI has a substantial speed advantage. Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.
