Preventive effect of @entity7954 on XXXX induced by @entity3952 in @entity840 .

@entity7955 @entity3952 @entity7954 @entity649 @entity840 @entity26 @entity651 @entity519 @entity855 @entity647
@entity3952 -induced @entity519 is an animal model of @entity649 ( @entity649 ). Increased capillary permeability is a cause of @entity519 in @entity651 . Endothelial cells form a major capillary barrier, and disruption of the barrier appears to involve a decreased level of @entity855 in the cells. @entity7954 ( @entity7955 ) is an endogenous substance that is one of the @entity855 precursors and can cross some cell membranes via anion exchanger. We examined the effect of @entity7955 on @entity3952 -induced @entity651 in @entity840 . An intravenous injection of @entity3952 (15 microl/kg) caused severe @entity519 . Pretreatment with @entity7955 at a dose of 2, 20, or 200 micromol/kg attenuated the @entity3952 -induced decrease in the arterial partial pressure of @entity26 in a dose-dependent manner. Furthermore, @entity7955 attenuated the @entity3952 -induced increase in vascular permeability in the proximal and distal bronchi, as indicated by the extravascular leakage of Evans Blue dye. The combination of @entity7955 with @entity855 (4 micromol/kg) showed no additional inhibitory effect on @entity3952 -induced @entity651 , compared with @entity7955 alone. We suggest that @entity7955 is a promising candidate to prevent @entity519 in @entity647 associated with increased vascular permeability, such as @entity649 .
