[Therapeutic effect of some antibiotics on experimental staphylococcal infection and its correlation with in vitro activity of antibiotics in sub-inhibitory concentration against XXXX strains].

@entity801 @entity19 @entity5152 @entity6186 @entity95 @entity794 @entity281 @entity1793
The aim of the study was to demonstrate of whether the therapeutic effects of antibiotics depend on their in vitro activity in sub-inhibitory concentrations against staphylococci. @entity5152 , @entity801 and @entity6186 were used in the study. Groups of @entity794 strains, containing 6 strains with similar MIC values each but different sensitivity to sub-inhibitory antibiotic concentrations (sub-MIC) were selected (a total of 36 trains): i. strains increasing their sensitivity to phagocytosis and bactericidal activity of @entity95 leukocytes after incubation with an antibiotic in 0.1 MIC concentration, ii. strains with sensitivity to the above factors unaffected by incubation with an antibiotic in 0.5 MIC concentration. The doses of staphylococci causing death of 90-100% of Swiss albino @entity19 10 days after i.p. infection were determined. The injected doses (LD 90-100) and various doses of antibiotics were used to determine ED50 values as well as the survival rate of the @entity19 with experimental @entity1793 after treatment with these antibiotics. It was demonstrated that effective doses (ED 50) of the antiboitics were significantly lower when the antibiotics were administered once to @entity19 infected with strains @entity794 sensitive to sub-MIC concentrations of the investigated antibiotics than for @entity19 infected with strains resistant to their sub-MIC concentrations. Similar correlations were observed in @entity19 which were given the antibiotics several times (for 7 days): the percentage of the surviving @entity19 was higher in the group infected with sub-MIC sensitive strains. The therapeutic effect of @entity5152 , @entity801 and @entity6186 demonstrated a significant correlation with the @entity794 strains used to induce the @entity281 and their sensitivity, or lack of sensitivity in vitro, to phagocytosis and bactericdal activity of leukocytes in the presence of antibiotics in sub-MIC concentrations.
