XXXX , thyroid function, and @entity2690 resistance - is there a link? A longitudinal study.

@entity1 @entity353 @entity28 @entity2690 @entity1017 @entity214
BACKGROUND: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in @entity28 @entity1 and are most likely to be associated with @entity2690 resistance. However, clinical relevance of this association remains unclear. OBJECTIVES: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment - @entity2690 resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with @entity353 in @entity28 @entity1 . SUBJECTS AND METHODS: Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric @entity28 group (344 @entity1 were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI- @entity214 ) variations:  <=-0.5 (significant @entity353 ); 0.5-0 ( @entity353 ); and >0 ( @entity1017 ). Statistical analysis was performed using SPSS 19.0  . RESULTS: The prevalence of increased TSH levels was 9.3%. At baseline TSH (p=0.007), fT4 (p=0.006), and HOMA-IR (p<0.001) were positively correlated to BMI- @entity214 (n=344). Weight reduction was verified in 67 out of 100 cases but significant loss was present in only 21 cases. Decreases in both TSH and BMI- @entity214 were independently associated with decreases in HOMA-IR (p=0.005 and p=0.016, respectively). There was no correlation between TSH and BMI- @entity214 variation. Significant decreases in the HOMA-IR (p=0.006) were only achieved in the significant @entity353 group. CONCLUSIONS: The prevalence of hyperthyrotropinemia was lower than previously reported. However, cutoff values were adjusted to pubertal stage, suggesting an over report in other studies. @entity2690 resistance and TSH were positively correlated, independent of body status. Although @entity353 was not associated with TSH variation, a decrease in TSH levels was independently associated with decreases in HOMA-IR.
