Expression of @entity20929 in the XXXX kidney.

@entity3372 @entity548 @entity12584 @entity20929 @entity1808 @entity1483 @entity1826 @entity1827 @entity35 @entity551
@entity20929 are expressed in the @entity35 kidney, but the factors that regulate this expression remain unknown. To try to understand what these might be, we have measured the renal levels of @entity20929 mRNAs by the ribonuclease protection-assay technique after a number of clearly defined renal/hemodynamic insults. 1) Six hours after the induction of @entity548 and @entity551 , there was a threefold increase in @entity1827 mRNA and a simultaneous threefold decrease in @entity1826 mRNA. This indicates that, in this situation, these two ET isoforms are differentially controlled and emphasizes the need for assay techniques capable of distinguishing between them. 2) One day after application of a 0.2-mm clip to the left renal artery, there was a > 2.5-fold induction of @entity1827 mRNA in that kidney, which persisted for 10 days. A smaller rise in @entity1827 mRNA was seen in the contralateral organ. After 2 days, @entity1826 mRNA levels were reduced by approximately 50% in the clipped organ. Both @entity3372 (an angiotensin-converting enzyme inhibitor, 7.5 mg/kg daily) and @entity12584 (a nonselective ET receptor antagonist, 100 mg/kg daily) substantially reduced the elevation in @entity1827 mRNA seen in the clipped kidney after 2 days, suggesting that the generation of @entity1808 and the action of ET itself are involved in the mechanism by which clipping stimulates @entity1827 expression. By contrast, @entity3372 , but not @entity12584 , prevented the reduction in @entity1826 mRNA levels. 3) Renal denervation, dietary salt restriction, or diuretic treatment ( @entity1483 ) did not alter renal expression of @entity1827 or @entity1826 .(ABSTRACT TRUNCATED AT 250 WORDS)
