Effect of coriander seed (Coriandrum sativum L.) XXXX extract on insulin release from pancreatic beta cells in @entity3839 -induced @entity6 @entity35 .

@entity627 @entity6 @entity3839 @entity406 @entity4543 @entity158 @entity35 @entity1068 @entity413
Coriander (Coriandrum sativum L.) is grown as a spice crop all over the world. The seeds have been used to treat indigestion, @entity6 , @entity627 and @entity158 in the joints. In the present study, an @entity1068 extract of the seeds was investigated for effects on insulin release from the pancreatic beta cells in @entity3839 -induced @entity6 @entity35 . Blood samples were drawn from the retro-orbital sinus before and 1.5, 3 and 5 h after administration of the seed extract. Serum @entity413 levels were determined by the @entity413 oxidase method. To determine the insulin releasing activity, after extract treatment the animals were anaesthetized by @entity4543 , the pancreas was excised, fixed in 10% @entity406 and embedded in paraffin for sectioning. Pancreatic sections of 5 microm were processed for examination of insulin-releasing activity using an immunocytochemistry kit. The results showed that administration of the @entity1068 extract (200 and 250 mg/kg, i.p.) exhibited a significant reduction in serum @entity413 . Administration of @entity3839 decreased the number of beta cells with insulin secretory activity in comparison with intact @entity35 , but treatment with the coriander seed extract (200 mg/kg) increased significantly the activity of the beta cells in comparison with the @entity6 control @entity35 . The extract decreased serum @entity413 in @entity3839 -induced @entity6 @entity35 and increased insulin release from the beta cells of the pancreas.
