Serum transforming growth factor-beta levels depend on allergen exposure in XXXX .

@entity1 @entity32 @entity2023 @entity13366 @entity2533 @entity56 @entity688
BACKGROUND: @entity2023 ( @entity2023 ) is characterized by @entity32 sustained by dysregulated immune response. T-regulatory cells are involved in @entity2023 pathogenesis, mainly producing @entity688 and transforming growth factor (TGF)-beta. Indeed, there is a functional and allergen-specific defect of T-regulatory cells in @entity2023 . However, there are no data about the influence of allergen exposure on @entity2533 serum levels. Therefore, the aim of this preliminary study was to evaluate @entity2533 serum levels in @entity1 with seasonal @entity2023 . @entity1 were evaluated either outside the pollen season and after 1 preseasonal @entity13366 ( @entity13366 ) course (38 subjects) or during the pollen season (57 subjects). METHODS: All @entity1 were @entity56 to Parietaria and/or grasses alone. @entity2533 was measured by a commercially available kit. Symptoms, drug use and eosinophils were evaluated.Serum allergen-specific IgG and IgA levels were also measured by the ELISA method. RESULTS: @entity2533 serum levels were significantly lower in @entity1 evaluated outside the pollen season in comparison with the other 2 situations. @entity13366 induced the significantly highest @entity2533 serum levels. There was a significant negative relationship between @entity2533 and eosinophils in @entity1 after @entity13366 . IgG and IgA levels were higher in @entity13366 -treated @entity1 . CONCLUSION: This preliminary study provides evidence that @entity2533 serum levels are significantly dependent on allergen exposure.
