Neonatal Genetic Variation in XXXX Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids.

@entity1 @entity20583 @entity18160 @entity649 @entity25085 @entity479 @entity24715 @entity11819 @entity6192 @entity288
UNASSIGNED: Objective   The aim of the study is to evaluate the association of @entity479 metabolism and respiratory gene polymorphisms in neonates exposed to antenatal @entity288 (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS. Study Design   This candidate gene study is a secondary analysis of @entity1 enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 @entity479 metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with @entity649 ( @entity649 ), continuous positive airway pressure (CPAP)/ventilator use ( @entity24715 ), and SGA. Results   @entity11819 , @entity6192 , and @entity20583 minor alleles were associated with an increased risk of SGA. @entity18160 and @entity25085 minor alleles were associated with an increased likelihood of @entity649 . Carriage of minor alleles in SerpinA6 was associated with an increased risk of @entity24715 . @entity6192 and @entity20583 minor alleles were associated with a decreased likelihood of @entity24715 . Conclusion   @entity479 metabolism and respiratory gene SNPs are associated with respiratory outcomes and SGA in @entity1 exposed to ACS. Risks for respiratory outcomes are affected by minor allele carriage as well as by treatment with multiple ACS.
