Pregnancy does not accelerate corticotroph XXXX progression in Nelson's syndrome.

@entity1 @entity4545 @entity101 @entity6 @entity5 @entity532 @entity699 @entity3036 @entity204 @entity2241
CONTEXT: Pituitary surgery is the first line of treatment for @entity699 ; when surgery fails, bilateral adrenalectomy may be proposed, particularly for @entity1 with a desire for pregnancy. Little is known about the impact of pregnancy on corticotroph @entity5 progression after bilateral adrenalectomy. OBJECTIVE: The aim was to evaluate the impact of pregnancy on corticotroph @entity5 progression after bilateral adrenalectomy in @entity699 and to assess maternal and pregnancy outcomes. DESIGN: We conducted a retrospective cohort study. SETTING: @entity1 who became pregnant after bilateral adrenalectomy were followed in a single center. @entity1 : Twenty pregnancies from 11 @entity1 with @entity699 were treated by bilateral adrenalectomy and no pituitary irradiation. MEASUREMENTS: Corticotroph @entity5 progression was assessed by serial pituitary magnetic resonance imaging and plasma @entity4545 measurements before, during, and after pregnancy. Comparisons were performed using paired Wilcoxon rank tests. Data on maternal and neonatal outcomes were recorded by correspondence from @entity1 and obstetricians. RESULTS: Corticotroph @entity5 progression occurred in eight of 17 pregnancies, and @entity4545 increased in eight of 10 pregnancies. However, rates of increase during or after pregnancy were not faster than those observed before pregnancy. @entity532 occurred in four pregnancies from two @entity1 , including gestational @entity101 in three and @entity6 in three. Among these four pregnancies, three had a favorable outcome, and one led to an in utero @entity204 after @entity3036 , due to loss to follow-up. No other @entity2241 were reported. CONCLUSION: Pregnancy does not accelerate corticotroph @entity5 progression after bilateral adrenalectomy. Pregnancy is manageable, provided the @entity1 can be followed closely.
