Association between inflammatory markers and liver fat: The Multi-Ethnic Study of XXXX .

@entity1 @entity650 @entity82 @entity1560 @entity409 @entity1561 @entity731 @entity13228 @entity1851
BACKGROUND: @entity1561 ( @entity1561 ) is a common @entity409 . Data is emerging that an independent association between markers of subclinical @entity731 and @entity1561 exists and it may be considered as an independent predictor of cardiovascular (CV) outcomes. We aim to better characterize the relationship between @entity1561 and inflammatory markers in a multi-ethnic cohort by assessing @entity1560 on computed tomography (CT) scans. METHODS: The Multi-Ethnic Study of @entity731 (MESA) is a longitudinal, population-based study from four ethnic groups free of CV disease at baseline. The inflammatory markers studied include: @entity1851 ( @entity1851 ) and @entity650 ( @entity650 ). On CT scans liver-to-spleen ratio (LSR: Hounsfield Units (HU) of the liver divided by HU of spleen) of <1 and liver attenuation of <40 HU were used as criteria for @entity1560 . Unadjusted and adjusted multivariate linear and logistic regression analysis was performed. RESULTS: 4038 @entity1 amongst 6814 MESA population with visible spleen on the CT scan, available @entity1851 and @entity650 levels and no reported liver @entity82 were included. The average age was 61 +/- 10 years, 37% Caucasians and 45% were males. Mean @entity1851 and @entity650 were 2.36 mg/dl and 1.37 pg/ml respectively. 696 @entity1 (17%) had LSR of <1 and 253 (6%) had liver attenuation of <40 HU. When using LSR <1 as a continuous variable, the correlation (adjusted odds ratio (OR)) with @entity1851 >2.0 was 0.037 (95% CI: 0.02-0.054) and with @entity650 was 0.014 (95% CI: 0.004-0.023). On the other hand when presence and absence of LSR <1 was considered, higher ORs for association with @entity13228 : 1.41 (95% CI: 1.16 to 1.73) and @entity650 :1.18 (95% CI: 1.05 to 1.31) were found. Similarly, the adjusted association of per unit decrease in liver attenuation with @entity13228 was 1.92 (95% CI: 1.20 to 2.63) while for @entity650 was 1.08 (95% CI: 0.69 to 1.47). When considering presence and absence of liver attenuation <40 HU the OR for @entity13228 was 2.27 (95% CI: 1.62 to 3.16) and for @entity650 was 1.33 (95% CI: 1.13 to 1.58). CONCLUSION: @entity1851 and @entity650 levels were found to be significantly associated with liver fat assessed on CT scan after adjusting for other risk factors for @entity731 .
