XXXX -related mortality in Brazil: a neglected condition of a neglected disease.

@entity1203 @entity204 @entity532 @entity1201
BACKGROUND: @entity1201 is a public health problem and a neglected condition of morbidity and mortality in several countries of the world. We analysed time trends and spatiotemporal patterns of @entity1201 -related mortality in Brazil. METHODS: We performed a nationwide population-based study using secondary mortality data. We included all @entity204 that occurred in Brazil between 2000 and 2011, in which @entity1201 was mentioned in any field of @entity204 certificates. RESULTS: @entity1201 was identified in 7732/12 491 280 @entity204 (0.1%). Average annual age-adjusted mortality rate was 0.43 @entity204 /100 000 inhabitants (95% CI 0.40-0.46). The burden of @entity204 was higher among males, elderly, black race/colour and in @entity1201 regions. @entity1203 was the most common clinical form mentioned. Mortality rates showed a significant nationwide decrease over the period (annual percent change [APC]: -2.8%; 95% CI -4.2 to -2.4). We observed decreasing mortality rates in the South, Southeast and Central-West regions, while the rates remained stable in North and Northeast regions. Spatial and spatiotemporal high-risk clusters for @entity204 were distributed mainly in highly endemic and socio-economically deprived regions. CONCLUSIONS: @entity1201 is a neglected cause of @entity204 in Brazil since the disease is preventable, and a cost-effective treatment is available. Sustainable control measures should include appropriate management and systematic monitoring of @entity532 , such as severe @entity1201 reactions and adverse effects to multidrug therapy.
