Morphological changes of cell proliferation and apoptosis in XXXX jejunal mucosa at different ages.

@entity35 @entity1975 @entity121
AIM: To study the changes of cell proliferation and apoptosis in @entity35 jejunal epithelium at different ages. METHODS: Cell proliferation and apoptosis of the jejunal mucosal and glandulous epithelia from birth to postnatal 12(th) month were observed using immunocytochemistry (ICC), and TUNEL method. The height of villus, the thickness of @entity121 and the number of goblet cells in jejunal mucosal and glandulous epithelia were measured by BeiHang analytic software and analyzed by STAT. RESULTS: (1) @entity1975 ( @entity1975 ) positive cells of jejunal glandulous recess were found and increased in number from birth to the postnatal 3(rd) month. The number of @entity1975 positive cells peaked in the postnatal 3(rd) month, and decreased from then on. (2) The number of apoptotic cells also peaked in the postnatal 3(rd) month, showing a similar trend to that of the @entity1975 positive cells. (3) The height of jejunal villus increased after birth, peaked in the postnatal 3(rd) month and decreased from then on. The jejunal @entity121 became thicker in the postnatal 3(rd) week and the postnatal 12(th) month. The number of goblet cells of the jejunal mucosal and glandulous epithelia had a linear correlation with age. CONCLUSION: (1) @entity1975 positive cells are distributed in the jejunal glandulous recess. (2) Apoptotic cell number peaks in the postnatal 3(rd) month, indicating that cell proliferation and apoptosis are developed with the formation of digestive metabolism as @entity35 grows to maturity. (3) The thickness of jejunal @entity121 increases to a maximum in the postnatal 3(rd) week, which may be related to the change in diet from milk to solid food. (4) The number of goblet cells increases rapidly in the postnatal 3(rd) week, probably due to ingestion of solid food.
