Exercise improves cognition in XXXX : The PRET- @entity191 randomized, clinical trial.

@entity1 @entity717 @entity2414 @entity191
BACKGROUND: This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in @entity191 ( @entity191 ) randomized, controlled trial. METHODS: This study was a prospective, parallel-group, single-center trial. Fifty-one nondemented @entity1 with mild-to-moderate @entity191 were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA). RESULTS: Eighteen @entity1 in mFC and 20 @entity1 in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; P   =   0.04) and Stroop (0.3; 0, 0.6; P   =   0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; P   <   0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; P   <   0.01) and Stroop (0.3; 0.1, 0.5; P   =   0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; P   <   0.01), Stroop (0.2; -0.1, 0.6; P   =   0.048), and BTA (0.3; 0, 0.8; P   =   0.048). No neurological or cognitive adverse events were observed. CONCLUSIONS: This study provides class IV level of evidence that 24 months of PRET or mFC may improve @entity2414 in nondemented @entity1 with mild-to-moderate @entity191 .    2015 International Parkinson and @entity717 Society.
