Expression of circulating microRNA-1 and microRNA-133 in pediatric @entity1 with XXXX .

@entity1 @entity1165 @entity591 @entity9630 @entity4710 @entity943
UNASSIGNED: Paroxysmal or persistent @entity591 in pediatric @entity1 is a common disease. Certain circulating microRNAs (miRNAs) have been associated with @entity943 . The present study investigated miRNAs in the plasma of pediatric @entity1 with @entity591 . Forty pediatric subjects were included retrospectively: 24 with recurrent sustained @entity591 [seven cases of @entity1165 ( @entity1165 ) and 17  cases of @entity4710 ( @entity4710 )] and 16  healthy controls. Circulating @entity9630 and miR  -133 in the plasma were detected by fluorescent quantitative polymerase chain reaction. @entity9630 levels were significantly decreased in the @entity943 group compared with those in the controls (P=0.004) whilst miR  -133 expression levels were not significantly different between the two groups (P=0.456). Both @entity9630 and miR  -133 levels showed significant differences between the @entity4710 and @entity1165 groups (P=0.004 and P=0.046, respectively), and a significant decrease in @entity9630 levels was observed in the @entity4710 group as compared with the controls (P<0.001). No significant difference was observed in the expression levels of miR  -133. By contrast, miR  -133 levels were significantly increased in the @entity1165 group compared with those in the controls (P=0.024), whereas no statistically significant difference was observed in the expression levels of @entity9630 . Receiver operating characteristic curves showed that 1/ @entity9630 was significant for the evaluation of @entity591 . Additionally, @entity9630 produced enhanced sensitivity and specificity for the evaluation of @entity4710 compared with miR  -133, whereas miR  -133 was a better marker to assess @entity1165 . This study demonstrated that miRNAs may be appropriate markers for pediatric @entity591 ; @entity9630 levels were decreased in the @entity943 group compared with those in the healthy controls. Furthermore, @entity1 with @entity4710 had lower @entity9630 expression levels while those with @entity1165 had higher miR  -133 expression levels.
