A feline model for experimental studies of peritumor XXXX .

@entity2657 @entity428 @entity5 @entity4 @entity11 @entity468
An in vivo model for correlative imaging studies of intracerebral @entity5 and peritumor @entity2657 has been developed. Adult male and female @entity468 implanted with 1 x 10(6) or 5 x 10(5) 9L @entity11 cells had parietal @entity5 of 4 mm or greater in diameter and showed signs of @entity428 13.7 +/- 1.9 days or 19.2 +/- 1.3 days after implantation. No immunosuppression was required and the success rate for @entity5 growth after implantation was 88%. Histologically, the @entity5 resembles a @entity5 . The @entity5 contained the highest water content (85.94%); peritumor white matter was more @entity4 (73.01%) than white matter in the contralateral hemisphere (69.04%), sham-operated (69.41%) and control brain (68.76%). There was no correlation between the size of the @entity5 and water content in @entity5 or white matter. Increased tissue albumin in peritumor white matter indicated blood-brain barrier dysfunction within the @entity5 and confirmed the vasogenic origin of the @entity4 . Proton magnetic resonance imaging provided good spatial and contrast resolution with increased signal intensity in @entity4 white matter, decreasing with distance from the @entity5 . The large brain of this animal model allows the use of serial imaging and regional correlative biochemical measurements in a single animal. Other advantages of this model are its predictability and the short time required to produce @entity5 with marked peritumor @entity4 .
