Treatment of locoregional @entity3 of XXXX with radiotherapy and intralesional beta-interferon injection.

@entity1 @entity5 @entity320 @entity3
Intralesional injection of beta-interferon can lead to remission of metastatic @entity320 . Simultaneous radiotherapy may augment the effect of these injections. The effect of intralesional beta-interferon injections combined with radiotherapy was examined in @entity1 with metastatic @entity320 . A total of 20 @entity1 with inoperable, incapacitating and disfiguring @entity320 were treated with simultaneous external beam radiotherapy (electrons and/or photons) and intralesional injection of beta-interferon. The total radiation dosage ranged from 40-50 Gy, fractionated as 1.8 Gy five times per week. beta-Interferon (Fiblaferon) 3-5 million units per injection was administered three times weekly until symptoms disappeared or until termination of therapy. One @entity1 was treated with beta-interferon alone; the area harbouring the @entity5 had been previously irradiated. Five @entity1 treated in this way showed partial remission after combined therapy and 12 showed complete remission, with permanent regression of @entity3 . The latter group included five @entity1 with lengthy survival times, including one @entity1 who has been free of symptoms for 7 years following treatment. Injected @entity3 showed complete regression in the @entity1 who was treated exclusively with beta-interferon post-irradiation. In conclusion, combined treatment with radiotherapy and intratumoral injection of beta-interferon controlled local @entity5 growth in inoperable metastatic @entity320 .
