XXXX : a novel approach to thyroid ablative therapy for @entity2743 .

@entity1 @entity32 @entity1496 @entity82 @entity3937 @entity2743 @entity39 @entity1416 @entity887 @entity5652 @entity1374
Despite the availability of effective treatments for @entity2743 , there are @entity1 who are unable to tolerate, or choose not to accept, current therapies (oral medication, radioactive @entity1496 , or surgery). In this study, we have examined the use of @entity1374 as an option for @entity1 who suffer from @entity2743 and who fit into one of the preceding @entity1 groups. Selective arteriography, followed by @entity887 of thyroid arteries, was performed using Seldinger's technique in 22 @entity1 with @entity2743 . Six of the @entity1 received both @entity1416 and surgery at 2-3 wk after @entity887 . No serious complications were noted in any @entity1 . In those who were treated with only interventional @entity887 , 14 of 22 (63.6%) became euthyroid and remained in this state for the duration of the study. The remaining 2 @entity1 required a maintenance dose of antithyroid drug therapy ( @entity3937 , 5-10 mg/d; or @entity5652 , 50-100 mg/d). @entity1 were followed for a median time of 27 months (range, 6-50). At the end of the follow-up period, all 22 @entity1 were euthyroid, the size of thyroid gland had decreased by one third to one half its original volume, but 2 @entity1 continued to require antithyroid drugs. Histologic analysis of thyroid tissue from 6 @entity1 who had @entity887 followed by surgery showed that @entity887 blocked both the superior and inferior thyroid arteries plus most of their branches. Evidence of chemical @entity32 , @entity39 , and @entity82 were observed in embolized thyroid tissue. The average diameter of capillary network within the body of the thyroid adjacent to superior and inferior artery was 0.12-0.25 mm, with the smallest ones ranging from 0.04-0.11 mm. The diameter of the capillaries in the isthmus ranged from 0.13-0.15 mm. The average diameters of the superior and inferior arteries were 2-5.5 and 3-3.75 mm, respectively, measured using radiographs from angiography. Based on the measured diameters of arteries, the appropriate size of embolizing granules can be selected, and complete @entity887 of the majority of the thyroid glands was achieved with a high frequency of therapeutic success. Histological examination of the thyroid tissue and clinical follow-up after @entity887 indicate that this procedure is an effective, minimally invasive, and safe method for the treatment of @entity2743 @entity1 who cannot, or choose not to, accept current therapies.
