Repeated liver resection for recurrent XXXX .

@entity5 @entity1 @entity157 @entity409
BACKGROUND AND AIM: @entity5 recurrence after liver resection occurs in the majority of @entity1 with @entity157 ( @entity157 ). This study was conducted to clarify the safety and effectiveness of repeated liver resection as a curative option for intrahepatic @entity157 recurrence. METHODS: Between July 1990 and January 2009, 483 @entity1 underwent 514 curative hepatic resections for @entity157 in our institution. Among this collective, 27 @entity1 underwent 31 repeated resections due to recurrent @entity157 (27 s resections, three third resections and one forth resection). The outcome of these @entity1 was retrospectively reviewed using a prospective database. RESULTS: Perioperative morbidity and mortality was 11% (three of 27) and 0%. Six @entity1 showed @entity409 , 23 underwent minor liver resections (fewer than three segments) and five @entity1 underwent major resections (three or more segments). The majority of the @entity1 showed no signs of @entity409 (16 of 27). The median @entity5 free margin was 1.5 mm (range: 0 to 20 mm). The median @entity5 diameter was 40 mm (range: 10 to 165 mm). @entity5 dedifferentiations at time of @entity5 recurrence were not observed. The 1-, 3- and 5-year overall survival rates after second liver resection were 96%, 70% and 42%. CONCLUSIONS: Repeated liver resection is a valid and safe curative therapy option for recurrent @entity157 and results in significant prolongation of survival in comparison to interventional treatment strategies in selected @entity1 . However, due to @entity409 , multifocal intrahepatic or extrahepatic recurrence repeated resection is only feasible in a minority of @entity1 .
