Muscle and Joint Factors Associated With XXXX in the @entity6 Neuropathic Foot.

@entity1 @entity6 @entity16 @entity3949 @entity1897 @entity2412 @entity85 @entity121
BACKGROUND: @entity6 are a known risk factor for skin breakdown and amputation, but the causes of deformity are not well understood. The purposes of this study were to determine the effects of intrinsic foot @entity121 and limited ankle joint mobility on the severity of @entity85 , and determine the relationships between these potential contributing factors and indicators of @entity2412 ( @entity1897 and advanced glycation end products). METHODS: A total of 34 @entity1 with @entity3949 (average age, 59 years; range 41-73) were studied. MTPJ angle and intrinsic foot @entity121 were measured with computed tomography and magnetic resonance imaging, respectively. Maximum ankle dorsiflexion was measured using kinematics. Skin intrinsic fluorescence served as a proxy measure for advanced glycation end product accumulation. RESULTS: Total forefoot lean muscle volume (r = -0.52, P < .01) and maximum ankle dorsiflexion (r = -0.42, P < .05) were correlated with severity of @entity85 . Together they explained 35% of the variance of MTPJ angle. @entity16 was correlated with forefoot @entity121 (   = 0.53, P < .01). Skin intrinsic fluorescence was correlated to severity of @entity16 (r = 0.50, P < .01) but not maximum ankle dorsiflexion, or forefoot deterioration when controlling for @entity16 . CONCLUSION: These results suggest that the interplay of intrinsic foot @entity121 and limited ankle mobility may be the primary contributor to the development of @entity85 . Identifying these muscle and ankle motion impairments as risk factors for @entity85 supports the need for targeted interventions early in the disease process to slow, or possibly stop the progression of deformity over time and reduce the risk of amputation. LEVEL OF EVIDENCE: Level IV, case series.
