@entity9367 attenuates @entity8 in @entity35 with XXXX .

@entity8 @entity82 @entity1695 @entity657 @entity9367 @entity2098 @entity618 @entity1810 @entity2528 @entity35 @entity631
AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity631 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity9367 (Trip). The present study was to investigate the effect of Trip on @entity8 in a model of @entity1695 ( @entity1695 ). METHODS: @entity1695 or sham-operated @entity35 were randomly assigned to receive @entity618 ( @entity2098 ), Trip or vehicle and were killed on days 7 and 14 after @entity1695 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity657 ( @entity657 ) and osteopontin. Interstitial collagen deposition and amounts of @entity1810 ( @entity1810 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity1810 , @entity2528 ( @entity2528 ), @entity657 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity657 and osteopontin, interstitial collagen deposition and amounts of @entity1810 were significantly reduced by @entity2098 or Trip. @entity2098 or Trip significantly reduced the mRNA expression of @entity1810 , @entity2528 , @entity657 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity82 in a @entity35 @entity1695 model and the effect of Trip on @entity8 was similar to that of @entity2098 . Trip may be useful as a potential candidate in the treatment of @entity8 .
