Alterations in functional connectivity of resting state networks during experimental XXXX - An exploratory study in healthy @entity1 .

@entity1 @entity32 @entity650 @entity5694 @entity146 @entity26 @entity400
UNASSIGNED: Systemic @entity32 impairs mood and cognitive functions, and seems to be involved in the pathophysiology of @entity146 . Functional magnetic resonance imaging (fMRI) studies revealed altered task-related blood- @entity26 -level-dependent (BOLD) responses during experimental @entity5694 , but little is known about effects of @entity32 on resting-state activity of the brain. Thus, we conducted a randomized, placebo-controlled study in healthy @entity1 receiving an intravenous injection of either low-dose (0.4ng/kg) lipopolysaccharide (LPS) (N=20) or placebo (N=25). Resting state activity was measured at baseline and 3.5h post-injection. Based on a two (condition)*two (group) design, we used multi-subject independent component analysis (ICA) to decompose and estimate functional connectivity within @entity400 ( @entity400 ). Seed-based analyses were applied to investigate the effect of LPS on the functional coupling for a priori-defined regions-of-interest (ROIs). ICA analyses identified 13 out of 35 components displaying common @entity400 . Seed based analysis revealed greater functional connectivity between the left thalamus and the cerebellum after LPS compared to placebo administration, while the functional coupling between seeds within the amygdala, insula, and cingulate cortex and various brain regions including parieto-frontal networks was significantly reduced. Within the LPS group, endotoxin-induced increases in @entity650 were significantly associated with resting-state connectivity between the left thalamus and left precuneus as well as the right posterior cingulate cortex. In summary, this exploratory study provides first evidence that @entity32 affects the coupling and regulation of multiple networks within the @entity1 brain at rest.
