Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in XXXX : the IFM experience.

@entity1 @entity34792 @entity66 @entity1582 @entity10267
UNASSIGNED: In @entity1582 , cytogenetic changes display important value for @entity1 ' outcome. In this setting, the most important changes are the del(17p), and the t(4;14), conferring a poor outcome. However, a certain heterogeneity is observed in survival of these high-risk @entity1 . We hypothesized that other chromosomal changes may impact the outcome. We retrospectively analyzed a large series of 242 @entity1 displaying either the t(4;14) (157 @entity1 ), or the del(17p) (110 @entity1 ), 25 @entity1 presenting @entity66 , using SNP-array. In @entity1 with t(4;14), del(1p32) (p<0.001), del22q (p<0.05) and more than 30 chromosomal structural changes (p=0.01) negatively impacted PFS. For OS, @entity34792 ) (p=0.01), del(1p32) (p<0.001), and the number of chromosomal structural changes (p<0.05 and p=0.01 for [10;30[and more than 30 structural changes, respectively) worsened the prognosis of @entity1 . For @entity1 with del(17p), del6q (p=0.01) worsened the prognosis of @entity1 , whereas @entity10267 (p=0.01) and monosomy 14 (p=0.03) were found to have a protective effect on PFS. For OS, del(1p32) (p=0.01) worsened the prognosis of @entity1 , whereas more than 8 numerical changes (p=0.004) was found to have a protective effect on survival. This study, which is the largest series of high-risk @entity1 , analyzed with the most modern genomic technique, identified one main factor negatively impacting survival: del(1p32).
