Intraocular lens material evaluation by XXXX abrasion in vitro: a scanning electron microscope study.

@entity4625 @entity1346 @entity95 @entity1539
Prosthetic posterior chamber intraocular lenses can abrade the @entity1539 pigmented epithelium, resulting in pigment dispersion, callus formation, and @entity1539 adhesions. To evaluate @entity1539 abrasion from intraocular lens materials, we developed an in vitro test and studied three materials: @entity4625 ( @entity4625 ), @entity1346 , and @entity4625 surface-modified by covalent binding of a hydrophilic polymer (surface-modified @entity4625 ). Each lens was rubbed 1,000 times on the posterior @entity1539 of pigmented @entity95 using a total force of 0.5 gram. Scanning electron micrographs of the abraded irides were scored using a subjective, nonparametric numerical scale. @entity4625 lenses removed @entity1539 epithelium completely, exposing underlying connective tissue. @entity1346 lenses damaged an area longer and narrower than the @entity4625 lens and also exposed connective tissue. Surface-modified @entity4625 lenses caused only slight surface damage, including flattening or breaking of protruding suspensory ligaments. The test conditions used cannot precisely mimic prolonged lens implantation in living subjects. Nevertheless, the results indicate that @entity1539 -lens interaction may be reduced in vivo by using a surface-modified @entity4625 lens. This hypothesis should be further verified by animal implantation studies.
