Quality of life after XXXX diagnosis and survival.

@entity1 @entity5 @entity204 @entity0
PURPOSE: To examine the association of quality of life (QOL) after diagnosis of @entity0 with mortality and recurrence. @entity1 AND METHODS: From 2002 to 2004, a total of 2,230 @entity0 survivors completed the General Quality of Life Inventory-74 6 months after diagnosis as part of the Shanghai @entity0 Survivor Study. Also collected at baseline was information on demographic and clinical characteristics. At 36 months postdiagnosis, 1,845 of these @entity1 were re-evaluated for QOL. Outcomes were ascertained by in- @entity1 interview and record linkage to the vital statistics registry. The association of QOL with total mortality and @entity5 recurrence was assessed by using Cox regression analysis. RESULTS: During a median follow-up of 4.8 years after the 6-month postdiagnosis QOL assessment, 284 @entity204 were identified. Recurrence was documented in 267 @entity1 after 108 @entity1 with @entity0 or recurrence before study enrollment were excluded. @entity1 with the highest tertile of social well-being QOL score, compared with those with the lowest score, had a 38% decreased risk of mortality (95% CI, 0.46 to 0.85; P for trend = .002) and a 48% decreased risk of @entity0 recurrence (95% CI, 0.38 to 0.71; P for trend < .001). QOL assessed at 36 months postdiagnosis was not significantly associated with subsequent risk of mortality or recurrence. CONCLUSION: Social well-being in the first year after @entity5 diagnosis is a significant prognostic factor for @entity0 recurrence or mortality, suggesting a possible avenue of intervention by maintaining or enhancing social support for @entity1 soon after their @entity0 diagnosis to improve disease outcomes.
