Retinal Blood Flow and Retinal Blood @entity26 Saturation in Mild to Moderate XXXX .

@entity1 @entity6 @entity2479 @entity26 @entity9734
Purpose: The aim of this study was to evaluate the relationship between @entity2479 ( @entity2479 ) and retinal blood @entity26 saturation ( @entity9734 ) in mild to moderate nonproliferative @entity6 (NPDR) and in age-matched controls. Methods: One eye of each of 15 healthy subjects (68    6 years) and 13 subjects with mild to moderate NPDR (67    10 years) was dilated. None of the @entity1 with NPDR had received treatment for their retinopathic changes or had any evidence of sight-threatening characteristics. Doppler Fourier-domain optical coherence tomography blood flow was measured using the prototype RTVue system; six separate measurements each comprising an upper and a lower nasal pupil scan were acquired. Six hyperspectral retinal measurements were acquired using a noninvasive hyperspectral retinal camera (prototype H-8.5 HR Camera). Results: Total @entity2479 was significantly lower in NPDR when compared to controls (42.7    7.5 vs. 33.0    9.2  L/min; P = 0.004). Mean retinal arterial and venular @entity9734 were higher in NPDR than in controls (94.7    2.4% vs. 92.9    1.6%, P = 0.02; 62.5    5.7% vs. 56.3    4.7%, P = 0.003). This study showed a correlation between @entity2479 and arteriolar @entity9734 in both controls (r = 0.58, P = 0.02) and NPDR (r = 0.54, P = 0.05), but no correlation between venular @entity2479 and venular @entity9734 in controls (r = 0.24, P = 0.83) or in NPDR (r = 0.23, P = 0.45). The arteriovenous difference (AV difference) was lower in the NPDR group when compared to controls (30.6    6 vs. 36.7    5.3, P = 0.008). Conclusions: This study found a lower total @entity2479 and a lower AV difference in the NPDR group, suggesting a reduced @entity26 uptake from the retina in @entity1 with relatively early @entity6 .
