Effect of @entity353 on subclinical XXXX : A clinical trial comparing gastric bypass surgery and intensive lifestyle intervention.

@entity1 @entity296 @entity712 @entity353 @entity1674 @entity5845
AIMS: To investigate the effect of @entity353 induced by bariatric surgery and intensive lifestyle intervention on levels of circulating high-sensitivity cardiac troponin I. METHODS AND RESULTS: We measured high-sensitivity cardiac troponin I concentrations pre- and 12 months post-intervention in 136 subjects with @entity5845 participating in a controlled clinical trial comparing the effect of intensive lifestyle intervention vs. Roux-en-Y gastric bypass. At baseline median (interquartile range) high-sensitivity cardiac troponin I levels were 2.40 (1.28-3.95) ng/L in the bariatric surgery group and 2.35 (1.38-4.40) ng/L in the intensive lifestyle intervention group (p   =   0.736). The high-sensitivity cardiac troponin I concentration in a normal-weight control group was 0.90 (0.60-2.13) ng/L. During 12 months of follow-up, high-sensitivity cardiac troponin I decreased significantly more in the bariatric surgery group than in the intensive lifestyle intervention group (0.80 (0-1.80) vs. 0.15 (-0.50 to 1.00) ng/L; p   =   0.002). In a multivariate logistic regression model, surgery emerged as a predictor of reduction in high-sensitivity cardiac troponin I levels (odds ratio 2.32; 95% confidence intervals 1.03-5.22; p   =   0.041) independent of age, gender and other possible confounding baseline variables. In subsequent multivariate analyses, reductions in body weight and @entity1674 emerged as possible mediators of reduction in circulating levels of high-sensitivity cardiac troponin I. CONCLUSION: In @entity1 with @entity5845 , bariatric surgery was associated with a significantly greater reduction in high-sensitivity cardiac troponin I, an index of subclinical @entity296 , than intensive lifestyle intervention. The reduction appeared to be mediated by reductions in body weight and serum @entity1674 . This suggests that @entity353 following bariatric surgery may reduce cardiometabolic stress and subsequent risk of @entity712 .
