Fast neutrons in the treatment of locally advanced XXXX .

@entity1 @entity0 @entity440 @entity39 @entity5 @entity1066 @entity158 @entity3 @entity204
The clinical investigation of fast neutrons at Hammersmith Hospital included 17 @entity1 who between them had 20 T4 @entity0 . The majority of these @entity5 were @entity1066 and all were @entity158 . Ten had recurred after multiple other therapies. Complete local regression was achieved in all but one (95%) and no @entity5 recurred. Symptoms were relieved in all cases. Median survival was 26 months. Three @entity1 developed small areas of @entity39 following trauma of previous radiation. All the neutron treated breasts became fibrosed, but this was painless. Neutron treatment needed only 12 attendances over 28 days, in contrast to the best results from photon therapy which required 6-7 weeks followed by implant of radioactive wire and/or surgical excision. One @entity1 who had bilateral @entity5 received neutrons to the left breast and X-ray therapy (photons) to the right. The photon treated @entity5 did not completely regress and recurred. The neutron treated one completely regressed and did not recur. Neutrons were also more effective than @entity440 which causes complete regression in only about 30% of cases. It is suggested that neutron therapy is indicated for locally advanced @entity5 which do not respond to hormones. Since @entity3 were a common cause of @entity204 , there remains a need for an effective adjuvant treatment, acceptable to elderly @entity1 .
