Benefits and complications of photodynamic therapy of papillary XXXX .

@entity1 @entity1377 @entity1940 @entity6 @entity63 @entity1713 @entity5 @entity8702 @entity1829
OBJECTIVE: To evaluate the potential benefit and risks of photodynamic therapy (PDT) in the treatment of @entity1377 . DESIGN: Prospective, noncomparative, interventional case series. @entity1 : Five @entity1 with solitary @entity8702 on the temporal portion of the optic nerve presenting with exudative decompensation and decrease in visual acuity (VA). METHODS: All eyes received a standardized PDT treatment with 6 mg/kg body surface area verteporfin and application of 100 J/cm(2) light at 692 nm. One to three PDT courses were performed until resolution of exudation was achieved. A continuous follow-up was provided with documentation 1 week before and at 4 to 6 weeks, 3 months, and 12 months after the last treatment application. MAIN OUTCOME MEASURES: Functional parameters included best-refracted VA (Early Treatment @entity6 Study), and central scanning laser ophthalmoscope (SLO) scotometry and peripheral (automated perimetry) visual fields; anatomic parameters were presence of @entity1829 or @entity1713 (ophthalmoscopy) and @entity5 size (ultrasonography). RESULTS: Pretreatment VA levels ranged from 20/40 to 20/800; posttreatment levels ranged from 20/64 to 20/2000. Tumor regression with resolution of macular exudate and @entity1713 was obtained in all eyes. A decline in VA of 1, 3, and 10 lines, respectively, was documented in three @entity1 . Complications included transient decompensation of vascular permeability, occlusion of retinal vessels, and @entity63 of the optic nerve. CONCLUSIONS: PDT is successful in reducing @entity5 size and exudative activity. Vaso-occlusive effects at the level of the retina and optic nerve compromise the functional benefit. Parameters proven safe in @entity1940 may be inappropriate in retinal capillary lesions of the optic nerve.
