Kindling antagonism: a role for hindbrain XXXX in the development of site suppression following concurrent, alternate stimulation.

@entity935 @entity410 @entity1063 @entity2955
The concurrent, alternate electrical stimulation of the septal nucleus and the entorhinal cortex results in the development of fully generalized @entity410 at one site (dominant site) and the lack of development of kindled @entity410 at the other (suppressed or antagonized site). We have labeled this phenomenon kindling antagonism. Previous work from our laboratory has demonstrated that the whole brain depletion of @entity1063 (NE) eliminates the development of kindling antagonism. In the present study animals were treated with the neurotoxin @entity2955 ( @entity2955 ) as neonates. The neonatal administration of @entity2955 produced robust increases in brainstem and cerebellar NE levels and depletions of forebrain NE levels when assayed at maturity. Striatal @entity935 levels were spared by this treatment. Neonatal @entity2955 did not alter the development of the kindling antagonism phenomenon which is typically observed following concurrent, alternate stimulation of the septal nucleus and entorhinal cortex. Neonatal @entity2955 treatment significantly facilitated the rate of kindled @entity410 development at dominant sites but failed to alter thresholds for the elicitation of afterdischarges (AD) or patterns of development of AD durations. Other characteristics of kindling antagonism were similarly unaffected by @entity2955 treatment. These data suggest that brainstem and/or cerebellar NE are sufficient to mediate the development of kindling antagonism in the relative absence of forebrain NE.
