[Proliferative nodules in XXXX : a clinicopathological analysis of eight cases].

@entity1 @entity6841 @entity5 @entity75 @entity8205 @entity4483 @entity320
OBJECTIVE: To study the clinicopathologic features, differential diagnosis and prognosis of proliferative nodules(PNs) in @entity8205 (CMN). METHODS: Histopathologic evaluation and immunohistochemical study by EnVision method were carried out in 8 cases of PNs in CMN. The clinical information and follow-up data were analyzed. RESULTS: The age of @entity1 ranged from 1 to 54 years (mean 27.6 years). @entity5 were located on face (3 cases), on back (2 cases), upper extremities (2 cases) and lower extremities(1 case). Microscopically, PNs with expansile growth were observed in 8 cases of CMN. Melanocytes in PNs show variable pleomorphism with a mitotic activity of 0 to 4 per 10 high power fields. Blending of cells with adjacent CMN was noted in 6 cases. According to the morphology of melanocytes in PNs, it was classified into different types including large oval melanocytes (4 cases), small melanocytes (2 cases) and Spitz-nevus-like forms (2 cases). Immunohistochemically, melanocytes in PNs were consistent with those in adjacent CMN. They were diffusely positive for @entity4483 protein, but were either negative or focally positive for HMB45. Less than 5% of melanocytes were positive for Ki-67 in 8 cases of @entity6841 . Follow-up was available in all cases, ranging from 9 to 82 months. Seven @entity1 with excision of single @entity6841 in CMN were alive with no evidence of disease, while 1 @entity1 with multiple PNs in CMN was stable with disease after 62 months follow-up. CONCLUSIONS: @entity6841 is a rare @entity75 arising in CMN. Recognition of its specific histologic features can help to avoid being misdiagnosed as @entity320 . Long term follow-up should be recommended in @entity1 with PNs, especially in those with atypical histologic features. Further investigation is needed to elucidate its clinical behavior.
