Health-related quality-of-life parameters as independent prognostic factors in advanced or metastatic XXXX .

@entity1 @entity632 @entity1353 @entity5 @entity900 @entity1295 @entity448 @entity150 @entity3 @entity158 @entity1499 @entity136 @entity5713 @entity22
PURPOSE: This retrospective analysis examined prognostic significance of health-related quality-of-life (HRQoL) parameters combined with baseline clinical factors on outcomes (overall survival, time to progressive disease, and time to treatment failure) in @entity150 . @entity1 AND METHODS: Outcome and HRQoL (European Organization for Research and Treatment of @entity5 Quality of Life Questionnaire C30) data were collected prospectively in a phase III study assessing @entity136 and @entity900 versus @entity1499 , @entity5713 , @entity632 , and @entity900 in locally advanced or metastatic @entity150 . Prespecified baseline clinical factors (performance status, @entity5 -node- @entity3 staging, visceral metastases [VM], alkaline phosphatase [AP] level, number of metastatic sites, prior radiotherapy, disease measurability, sex, time from diagnosis, and sites of disease) and selected HRQoL parameters (global QoL; all functional scales; symptoms: @entity158 , @entity1295 , @entity22 , @entity1353 , @entity448 ) were evaluated using Cox's proportional hazards model. Factors with individual prognostic value (P <.05) on outcomes in univariate models were assessed for joint prognostic value in a multivariate model. A final model was developed using a backward selection strategy. RESULTS: @entity1 with baseline HRQoL were included (364 of 405, 90%). The final model predicted longer survival with low/normal AP levels, no VM, high physical functioning, low role functioning, and no @entity448 . Positive prognostic factors for time to progressive disease were good performance status, low/normal AP levels, no VM, and minimal @entity1295 ; for time to treatment failure, they were low/normal AP levels, minimal @entity1295 , and no @entity448 . Global QoL was a significant predictor of outcome in univariate analyses but was not retained in the multivariate model. CONCLUSION: HRQoL parameters are independent prognostic factors for outcome in advanced @entity150 ; their prognostic importance needs further evaluation.
