Efficacy of intravenous XXXX for pre-emptive @entity1337 .

@entity1 @entity7988 @entity1337 @entity158 @entity954
AIM: To determine whether intravenous @entity7988 is effective as pre-emptive @entity1337 for breast surgery. DESIGN: Randomised, controlled, double blind study. @entity1 AND METHODS: 50 @entity1 undergoing breast surgery under general anaesthesia randomised to receive either 100 mg intravenous @entity7988 30 minutes before (Group I), or immediately after @entity954 (Group II). Postoperatively, @entity158 scores (Visual Analogue Scale, VAS) and time to rescue analgesic were recorded by an independent, blinded observer. The study was terminated when rescue analgesic was required (VAS > or =4 or demand for analgesic). STATISTICAL ANALYSIS: Continuous variables were analysed by the unpaired 't' test, discrete variables with the chi square test, and survival curves by the log-rank test. RESULTS: @entity158 scores were significantly lower in Group I till 10 hours after surgery. The number of @entity1 requiring @entity1337 at 4, 6, 8 and 10 hours was significantly lower in group I (0% vs. 47% [P <0.0001], 0% vs. 44% [P <0.003], 0% vs. 80% [P <0.0001], 0% vs. 100% [P <0.0001] respectively). The mean time for rescue analgesic was 15.47 -/+ 2.87 hours in group I versus 4.22 -/+ 2.55 hours in group II (P <0.0001). CONCLUSION: Pre-emptive @entity1337 with Intravenous @entity7988 (100mg) produces better postoperative @entity158 -relief in @entity1 undergoing breast surgery.
