Effects of XXXX -induced @entity6 on postpneumonectomy lung growth and connective tissue levels.

@entity4116 @entity35 @entity6 @entity3839 @entity230
@entity6 is generally accompanied by abnormal levels of growth hormone and adrenal @entity230 , hormones known to modulate postpneumonectomy (post-PNX) compensatory lung growth. Thus, we examined the possibility that @entity6 may affect post-PNX lung growth processes. Left PNX was performed in young @entity6 @entity35 ( @entity3839 -induced; 75 mg/kg body weight) (DM-PNX) and in control @entity35 (C-PNX), for comparison with sham-operated control @entity35 (C-SHAM). The @entity35 were permitted free access to food and water. Examination at day 7 after surgery showed that right lung absolute dry weight and absolute DNA, collagen and @entity4116 contents were increased in C-PNX and DM-PNX @entity35 (but only C-PNX values reached those of both lungs in C-SHAM @entity35 ). Body weights (BW) of DM-PNX @entity35 were lower than those of C-PNX and C-SHAM @entity35 . Lung DNA/BW in C-PNX and DM-PNX @entity35 were comparable, and matched values for both lungs in C-SHAM @entity35 . Lung dry weight/BW, collagen/BW, and @entity4116 /BW in DM-PNX @entity35 exceeded values in C-PNX @entity35 and even more for values of both lungs in C-SHAM @entity35 . Data of another experiment, comparing DM-PNX @entity35 with body weight-matched (by food limitation) PNX and control @entity35 (WMC-PNX and WMC-SHAM @entity35 , respectively) indicated comparable lung absolute DNA contents in DM-PNX and WMC-PNX @entity35 (which matched values for both lungs in WMC-SHAM @entity35 ), however, lung absolute collagen and elastic contents were greater in the DM-PNX @entity35 .(ABSTRACT TRUNCATED AT 250 WORDS)
