Major histocompatibility antigens and lymphocyte subsets during @entity56 in the Lewis XXXX .

@entity32 @entity1008 @entity1885 @entity11264 @entity56 @entity35 @entity2443 @entity291
Major histocompatibility antigens were identified in frozen sections of normal Lewis @entity35 peripheral nerve tissue with monoclonal antibodies and an avidin- @entity1885 -peroxidase complex system. Class I antigen is normally required for cytotoxic/suppressor T lymphocyte function and class II antigen for activation of helper T lymphocytes. In the sciatic nerves class I antigen was expressed diffusely by most endoneurial and perineurial cells but class II antigen only by a minority. In the cauda equina class I antigen was expressed by all @entity2443 and some endoneurial cells, while class II antigen was expressed by a smaller proportion of @entity2443 cells in the endoneurium of spinal roots and interstitial cells surrounding dorsal root ganglion neurons. The endothelium of endoneurial, perineurial and meningeal vessels uniformly expressed class I but not class II antigen. @entity56 was induced in Lewis @entity35 by immunisation with @entity291 intradural root myelin. Early lesions consisted of multifocal infiltration of the nerve roots by cells expressing @entity1008 . Surrounding endoneurial cells showed markedly increased expression of major histocompatibility antigens. In inflammatory lesions about 10% of the cells were stained with pan T cell antibodies. T lymphocyte subsets were identified with antibody @entity11264 for helper cells and MRC OX-8 for cytotoxic/suppressor cells. The @entity11264 positive cells were usually slightly in excess of OX-8 positive cells and their relative proportions did not alter during the disease. The presence of class I antigen on normal endothelium and its increased expression on endoneurial cells in the early phase of @entity32 suggest an important role for class I restricted lymphocytes in the pathogenesis of the early stages of @entity56 .
