[Role of the @entity989 ( @entity989 ) in the pathogenesis and treatment of XXXX ( @entity1103 )].

@entity1 @entity2194 @entity6 @entity7 @entity2295 @entity532 @entity1103 @entity288 @entity519 @entity989 @entity13191
@entity13191 ( @entity13191 ) has recently been shown to be the most potent inhibitor of angiogenesis in the @entity1 eye, suggesting that loss of @entity13191 is involved in the pathogenesis of proliferative @entity6 . However, a protective role for @entity13191 in pericyte loss requires elucidation. Present studies suggest that @entity13191 proteins could protect against advanced glycation end product (AGE), which induce @entity989 . Substitution of @entity13191 proteins may be a promising strategy in the treatment of @entity1 with early @entity6 . Therefore, injury of @entity989 is the basic condition, not only of the progress of @entity2295 , but initiation of early @entity532 and @entity1103 as well. Recently new intravitreal drugs being used in the treatment of @entity2194 with increased level of VEGE. Intravitreally administered a human, monoclonal anti- @entity7 agent acts only as symptomatic treatment. It does not eliminate @entity519 and requires repeated administration. It is worth emphasizing, that @entity7 functions are not limited to active angiogenesis, but also seems to require the maintenance and differentiation of mature blood vessels, such as the choriocapillaris. Therefore, delivery of these anti- @entity7 treatments needs to be specific to sites of @entity2295 or limited to a short duration, to prevent disruption of the normal vasculature. The effective method, which preserves @entity989 , improves oxygenation and release traction on the macula, leading to decreased permeability with subsequent resolution in @entity1103 , is pars plana vitrectomy with ILM peeling. There are several investigations that support the theoretical value of vitrectomy for the treatment of @entity1103 . Intraoperative administration of anti- @entity7 agent and @entity288 may additionally improve results of operative treatment.
