Structural and functional changes in retinal vasculature induced by @entity2479 -reperfusion in XXXX .

@entity2000 @entity2479 @entity63 @entity989 @entity35 @entity6667 @entity528
UNASSIGNED: Recent studies have shown retinal blood vessel damage in experimental models of @entity2000 . The present study aimed to provide a detailed description of the structural and functional changes in retinal vasculature induced by @entity2479 -reperfusion (I/R) in @entity35 . @entity2479 was induced for 60  min by raising the intraocular pressure to 130  mmHg. Morphological changes in vascular components (endothelial cells, pericytes, and basement membranes), the patency and perfusion of blood vessels, and expression of @entity6667 ( @entity6667 ) were assessed in the retinas at 2, 7, and 14 days after I/R. Significant reductions in vascular densities were observed at 7 and 14 days after I/R. Pericyte loss occurred after the appearance of endothelial cell degeneration, whereas the vascular basement membranes remained unchanged. Some vessels showed no perfusion in damaged retina. A decrease in the immunoreactivity of @entity6667 in the region extending from the ganglion cell layer to the outer plexiform layer was evident 2  days after I/R. In retinal I/R model, @entity2479 cells are rapidly (<2 day) damaged following reperfusion, therefore, the current results suggest that neuronal cell damage precedes @entity528 , and neuronal cells may play an important role in maintaining vascular structure and function through the production and release of endothelial cell survival factors, including @entity6667 . Neuronal cell damage could be an additional cause of progression of @entity63 @entity989 by reducing blood supply to the retinal neurons due to the destruction of the blood vessel network.
