@entity2008 in XXXX .

@entity1 @entity784 @entity3191 @entity11728 @entity1892 @entity2008
Data on @entity2008 in @entity784 are very rare as compared with those reported in @entity1892 . We performed a cytogenetic study in 71 untreated @entity1 with @entity3191 , classified according to the criteria of the REAL classification. Fifty-seven @entity1 (80.3%) had abnormal clones, whereas 9 karyotypes (12.7%) showed only normal metaphases; 5 karyotypes (7%) could not be analyzed. Recurrent numerical @entity2008 comprised +3 (21%), +5 (15.7%), +7 (15.5%), +21 (14%), -13 (14%), +8 (12.2%), +19 (12.2%), -10 (10.5%), and -Y (9% of male @entity1 ). Chromosomes involved in structural rearrangements were chromosome 6 (31.5%), mainly due to 6q deletions (19.2%), 1q (22.8%), 7q (22.8%), 9p (19.4%), 9q (19.2%), 4q (19.2%), 3q (19.2%), 2p (17.5%), 1p (17.5%), and 14q (17%). Trisomies 3 and 5 mainly correlated with @entity784 . Isochromosome 7q, associated with trisomy 8, was present in two cases of @entity11728 /delta @entity784 . Rearrangements involving the location of T-cell receptor genes were rarely observed (chromosome band 7q35 was rearranged only in three cases, 14q11 in two cases, and 7p15 in none). No correlation could be found between the cytogenetic findings and histologic subgroup or clinical outcome in these @entity1 . Further studies are needed to understand the significance of these abnormalities in @entity3191 , and to reach a better evaluation of histologic correlations, as many differences persist between the two major classification systems, KIEL and REAL.
