@entity925 sensitivity after XXXX injection is not modified by systemic administration of monosodium glutamate.

@entity1 @entity3264 @entity101 @entity2956 @entity158 @entity367 @entity10 @entity925 @entity4202
BACKGROUND: Monosodium @entity3264 (MSG) is often thought to be associated with @entity10 and craniofacial @entity158 like @entity2956 . This randomized, double-blinded, placebo-controlled study was performed to investigate how ingestion of MSG affects @entity925 sensitivity before and after experimentally induced @entity925 . METHODS: Sixteen healthy adult subjects participated in 2 sessions with at least 1-week interval between sessions. In each session, two injections of @entity3264 ( @entity367 , 0.5 M, 0.2 ml) and two injections of saline (0.9%, 0.2 ml) into the masseter and temporalis muscles, respectively, were undertaken, with a 15 min interval between each injection. Injections of saline were made contralateral to @entity367 injections and done in a randomized order. @entity1 drank 400 mL of soda mixed with either MSG (150 mg/kg) or @entity4202 (24 mg/kg, placebo) 30 min before the intramuscular injections. Pressure @entity158 thresholds (PPT), autonomic parameters and @entity158 intensity were assessed prior to (baseline) and 30 min after ingestion of soda, as well as 5 min and 10 min after the intramuscular injections and at the end of the session. Whole saliva samples were collected prior to and 30, 45, 60, and 75 min after the ingestion of soda. RESULTS: MSG administration resulted in a significantly higher @entity367 level in saliva than administration of @entity4202 and was associated with a significant @entity101 . Injections of @entity367 were significantly more @entity158 than injections of @entity4202 . However, ingestion of MSG did not change the intensity of @entity367 -evoked @entity158 . @entity367 injections also significantly increased systolic and diastolic blood pressure, but without an additional effect of MSG ingestion. @entity367 injections into the masseter muscle significantly reduced the PPT. However, pre-injection MSG ingestion did not significantly alter this effect. Interestingly, PPT was significantly increased in the trapezius after MSG ingestion and intramuscular injection of @entity367 in the jaw muscles. CONCLUSION: The main finding in this study was that systemic intake of a substantial amount of MSG does not influence either @entity158 intensity or pressure @entity158 sensitivity in the masseter and temporalis muscles into which @entity367 injections were made.
