Impact of family history of XXXX on development of multiple primaries after diagnosis of @entity694 .

@entity1 @entity788 @entity263 @entity0 @entity5 @entity150 @entity694
PURPOSE: The purpose of this study was to assess risk of developing multiple primaries after a diagnosis of @entity694 and to determine the impact that having a family history of @entity5 has on @entity5 risk. METHODS: Data from the Utah Cancer Registry and the Utah Population Database were used. A cohort of 2,236 first primary @entity694 were observed for the subsequent development of additional primary @entity5 . RESULTS: We observed a greater than expected incidence of @entity788 among the cohort. The standardized incidence ratios were 2.77 (95 percent confidence interval (CI), 2.07-3.70), 2.26 (95 percent CI, 1.34-3.81), and 2.38 (95 percent CI, 1.32-4.30), respectively. Having a family history of @entity694 did not greatly influence risk of having a multiple primary. However, there was a trend toward increased risk of @entity788 (hazard rate ratios, 1.99; 95 percent CI, 0.67-5.90) and @entity150 (hazard rate ratios, 2.35; 95 percent CI, 0.77-7.18) among @entity1 with a family history of @entity5 . We also observed that risk of uterine @entity5 in the cohort was positively associated with family history of uterine @entity5 , risk of @entity0 was positively associated with family history of @entity0 , and risk of @entity263 was positively associated with family history of @entity263 . CONCLUSIONS: @entity1 with @entity694 are at a greater risk of developing @entity788 . Although a family history of @entity694 did not have a large impact on developing other @entity5 , a family history of other primary @entity5 did influence risk of other @entity5 .
