Effects of beta-casomorphin-5 on passive avoidance response in XXXX .

@entity5541 @entity19 @entity5172 @entity2730 @entity14719 @entity70551 @entity5591 @entity291
The effects of intracerebroventricular (i.c.v.) injection of @entity291 beta-casomorphin-5 (beta-CM-5: @entity70551 ), a micro-opioid agonist derived from milk beta-casein, on step-down type passive avoidance tasks were investigated in @entity19 . Intracerebroventricular administration of a high dose (10 microg) of beta-CM-5 produced a significant decrease in step-down latency. @entity5541 (5 microg, i.c.v.) almost completely reversed the beta-CM-5-induced shortening of step-down latency, although neither @entity5172 (5 ng, i.c.v.) nor @entity14719 (5 microg, i.c.v.) had any significant influence on the effect of beta-CM-5. Meanwhile, a low dose (0.5 microg, i.c.v.) of beta-CM-5 inhibited @entity5591 (1 mg/kg)-induced impairment of passive avoidance response. These results indicated that a high dose of beta-CM-5 induces @entity2730 , whereas a low dose ameliorates @entity5591 -induced @entity2730 .
