Myocardial XXXX -201 kinetics and regional flow alterations with 3 hours of @entity1563 and either rapid reperfusion through a totally patent vessel or slow reperfusion through a critical @entity850 .

@entity5045 @entity235 @entity1563 @entity4214 @entity1188 @entity432 @entity850
Myocardial @entity4214 -201 kinetics and regional blood flow alterations were examined in a @entity235 model using 3 hours of @entity1563 and different methods of reperfusion. Group I comprised 10 @entity235 undergoing a 3 hour left anterior descending @entity432 and no reperfusion. Group II comprised seven @entity235 undergoing 3 hours of left anterior descending @entity432 and rapid reperfusion through a totally patent vessel. Group III comprised 10 @entity235 undergoing 3 hours of left anterior descending @entity432 and slow reperfusion through a residual @entity850 . All @entity235 received 1.5 mCi of @entity4214 -201 after 40 minutes of @entity1563 . During occlusion and 2 hours of reperfusion, serial hemodynamic, blood flow and myocardial @entity4214 -201 activity measurements were made. The relative @entity4214 -201 gradient (normal zone minus ischemic zone activity when initial normal activity is expressed as 100%) during left anterior descending @entity1563 was similar in all groups. Group I, 87 +/- 3%; Group II, 78 +/- 6%; Group III, 83 +/- 6% (p = NS). After 2 hours of either method of reperfusion, the final relative gradient had decreased to a similar level (Group II, 51 +/- 9%; Group III, 42 +/- 6%). These values were not significantly different from the final relative @entity4214 -201 gradient seen in @entity235 undergoing a sustained 3 hour occlusion (Group I, 55 +/- 5%). After 2 hours of reperfusion, both methods of reflow were associated with similar degrees of "no reflow." Transmural flows in the central ischemic zone were 89 +/- 10% of normal in Group II and 71 +/- 6% of normal in Group III after reperfusion, with both flows substantially higher than the relative @entity4214 -201 activities in these @entity235 . @entity1188 size (percent of left ventricle) determined with @entity5045 was similar in all groups (Group I, 24 +/- 4%; Group II, 29 +/- 4%; Group III, 25 +/- 4%). Thus, in this experimental @entity235 model, 3 hours of @entity1563 followed by either rapid reperfusion through a totally patent vessel or slow reperfusion through a critical @entity850 resulted in little delayed @entity4214 -201 redistribution or myocardial salvage as assessed histologically, despite significant recovery of regional flow.
