Indications and effects of XXXX therapy in childhood.

@entity1 @entity296 @entity712 @entity101 @entity417 @entity3371 @entity4297
Chronic effects of @entity3371 were studied in 29 @entity1 (age, 4 months to 16 years; mean, 6.9 years) suffering from digitalis and diuretic resistant @entity712 ( @entity712 ) or @entity101 of different etiology. Twenty two @entity1 with @entity712 (13 dilated, 4 @entity296 , 5 @entity4297 ) and 7 cases with @entity101 were treated for 1 to 31 months (mean, 9 months). The dose of @entity3371 varied from 1 to 3 mg/kg/day (mean, 2.2 mg) in @entity712 and from 1.1 to 6.8 mg/kg/day (mean, 3.7 mg) in @entity101 . In @entity712 digoxin therapy was maintained while the dose of diuretics could be reduced or discontinued. In 4 severely @entity101 @entity1 the addition of a diuretic or beta blockers was necessary. In @entity712 clinical improvement was observed in 13 @entity1 (59%), while there was no response in 4 and 5 @entity1 died. The survivors exhibited a significant decrease of the cardiothoracic index (p less than 0.05), the PEP/LVET ratio (p less than 0.05) and an increase of the echocardiographic linear ejection fraction (p less than 0.001). If @entity101 was present, blood pressure decreased in all @entity1 (p less than 0.05). @entity3371 was well tolerated by all @entity1 except one who developed @entity417 . This side effect disappeared after having discontinued the drug. These findings suggest that @entity3371 is of benefit in controlling chronic @entity712 . @entity3371 alone or in combination with other drugs is effective in the management of severe @entity101 .
