Cytokine responses and correlations thereof with clinical profiles in XXXX with enterovirus 71 infections.

@entity1 @entity650 @entity32 @entity5737 @entity2789 @entity1356 @entity3124 @entity371 @entity687 @entity688 @entity204
BACKGROUND: Severe complications associated with EV71 infections caused many @entity1 @entity204 . However, the pathogenesis of EV71 infection in the severe cases remained poorly understood. METHODS: In this study we collected plasma and cerebrospinal fluid (CSF) specimens drawn in the acute and/or recovery phases from EV71-infected individuals, and plasma specimens from healthy @entity1 served as normal controls. We compared the levels of cytokines and chemokines determined by a Luminex-based cytokine bead array. RESULTS: The plasma levels of @entity1356 and @entity650 were significantly higher in severe and critical cases than in mild @entity1 and normal controls. Higher plasma levels of @entity650 , @entity688 , and @entity687 were evident in critical than severe cases. The CSF levels of @entity650 , @entity687 , and @entity371 were higher, and that of @entity5737 lower (compared to plasma), in severe and critical @entity1 . Significantly lower CSF levels of cytokines and chemokines were recorded in the recovery than the acute phase in severe and critical cases treated with intravenous immunoglobulin (IVIG) and glucocorticoids. Only the CSF levels of @entity650 , @entity371 , and @entity687 were significantly correlated with white blood cell counts, and absolute neutrophil and monocyte counts, in severe cases. Furthermore, the CSF levels of @entity650 were correlated with temperature in both cases. CONCLUSIONS: These data indicate that a major cytokine response and @entity32 , in both plasma and the CNS, are features of disease caused by EV71 infection. Systemic @entity32 caused by EV71 @entity2789 , and resulted in the disease progression to the @entity3124 stage.
