[Determination of liver XXXX by 1H MR spectroscopy].

@entity1 @entity1560 @entity1674 @entity72983 @entity209
BACKGROUND: @entity209 is responsible for increasing the fat content of the liver. Among several non-invasive methods of liver fat analysis, the most important role is played by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). This pilot study describes the methodology for measurements of @entity1674 in the liver in a group of liver transplant @entity1 using 1H MRS at 3T. METHODS AND RESULTS: Thirty-eight @entity1 (12 Female, 27 male, aged 19-71) who underwent routine preventive examination at IKEM were included in the MRS study. The fat content of liver biopsies was classified according to the number of affected hepatocytes, HIS. Based on this classification, there were 20 @entity1 with a @entity1560 score of S0, 15 @entity1 with a score of S1, 2 @entity1 with a score of @entity72983 @entity1 with a score of S3. 1H MR spectra were measured from three positions in the liver. Following Longo et al, the concentration of fat phi(fat), was calculated from the signal intensities of water and @entity1674 . Linear correlation between the number of affected hepatocytes and fat content was described by the equation: HIS = 6.4 phi(fat) -2.1; r2 = 0.85; p = 0.001. CONCLUSIONS: The pilot study confirmed that examination of fat content using 1H MRS at 3T is well tolerated by @entity1 . Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive and screening examination measurement of fat in the liver.
