@entity2946 : A common XXXX : Prognostic factors and predictors of outcome.

@entity1 @entity1313 @entity5 @entity2269 @entity2946
BACKGROUND: @entity2946 is a common @entity5 in the pediatric population, accounting for 25% of all childhood @entity1313 and relatively uncommon in adults. This review was to investigate treatment outcome and prognostic factors after treatment of @entity2946 . MATERIALS AND METHODS: A total of 53 @entity1 with histological confirmed @entity2946 cases treated at our institute between 2006 and 2012 were included in the study. Demographic variables, clinical variables, radiological findings and treatment details with respect to age, sex, signs and symptoms, location of @entity5 , extent of surgical resection, histopathology type, radiotherapy dose, follow-up period and outcomes were recorded. Survival was analyzed by using these parameters. RESULTS: Thirty-one (58.5%) @entity1 were pediatric (<14 years), and 22 (41.5%) @entity1 were adults (>= 14 years). Duration of symptoms were <3 months in 19 (36%) and more than 3 months in 34 (64%) @entity1 . @entity5 resection was performed in all @entity1 with gross total resection in 8 (15%) @entity1 , near total resection in 34 (64%) @entity1 and subtotal resection in 11 (21%) @entity1 . All @entity1 underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 36 Gy with additional boosts to the posterior fossa up to 54 Gy. Median overall survival was 50 months for the total group whereas 36 months for pediatric age group and 70 months for adult group. @entity2269 histology showed an improved outcome compared with other histologies with a median survival of 71 months compared with that of classical @entity2946 histology being 36 months and other histologies shown a median survival of 34 only. CONCLUSIONS: Treatment of @entity2946 with surgery and CSI yields long survival rates in both @entity1 and adults. Adult age group and desmoplastic histology were associated with a favorable outcome.
