The safety and efficacy of high-dose proton beam radiotherapy for XXXX : a phase 2 prospective trial.

@entity1 @entity82 @entity137 @entity5 @entity648 @entity3 @entity157 @entity99 @entity34
BACKGROUND: @entity34 ( @entity34 ) may provide useful local-regional treatment for @entity157 ( @entity157 ). The purpose of this study was to evaluate the safety and efficacy of @entity34 for @entity157 . METHODS: @entity1 with @entity82 who had radiological features or biopsy-proven @entity157 were included in the study. @entity1 without @entity82 and @entity1 with extrahepatic @entity3 were excluded. The mean age was 62.7 years. The mean @entity5 size was 5.5 cm. Eleven @entity1 had @entity5 , and 46% were within the Milan criteria. @entity1 received 63 Gy delivered over a 3-week period with @entity34 . RESULTS: Seventy-six @entity1 were treated and followed prospectively for treatment outcomes at Loma Linda University Medical Center. Acute @entity137 was minimal; all @entity1 completed the full course of treatment. @entity99 was evaluated using liver enzyme, @entity648 , and albumin levels; no significant change supervened 6 months posttreatment. Median progression-free survival for the entire group was 36 months, with a 60% 3-year progression-free survival rate for @entity1 within the Milan criteria. Eighteen @entity1 subsequently underwent liver transplantation; 6 (33%) explants showed pathological complete response and 7 (39%) showed only microscopic residual. CONCLUSIONS: @entity34 was found to be a safe and effective local-regional therapy for inoperable @entity157 . A randomized controlled trial to compare its efficacy to a standard therapy has been initiated. @entity5 2011.    2011 American @entity5 Society.
