Contribution of genetically engineered animals to the analyses of complement in the pathogenesis of XXXX .

@entity1310 @entity8 @entity66 @entity19 @entity18544 @entity631
The complement system is indispensable for host defence. Unregulated activation, however, is related to @entity66 . In order to elucidate the significance of complement, methodology that disrupts the complement system is essential. Advances in molecular genetics made direct modulations of the genes of complement components and their regulatory proteins feasible. One method is disruption of genes that encode complement components. Several studies have been conducted with these @entity19 in models such as nephrotoxic serum (NTS) @entity1310 , ischaemia reperfusion and immune complex-mediated @entity631 . These studies all showed that depletion of complement components ameliorated the severity of the diseases. Complement regulatory protein serves a regulatory role in the complement system. Genetically engineered animals that overexpress these proteins have been employed to elucidate their biological roles. @entity19 overexpressing soluble complement regulatory proteins were protected from the lesion of both NTS and the glomerular endothelial injury model. In contrast, knockout @entity19 that lack expression of @entity18544 ( @entity18544 ), a complement regulatory protein, developed severe @entity8 when subnephritogenic doses of NTS were administered. These genetically engineered animals shed light on the mechanism of initiation and progression of @entity8 .
