[Immediate @entity56 is rarely implicated in drug induced XXXX ].

@entity1 @entity1496 @entity1931 @entity117 @entity2690 @entity2886 @entity134 @entity56 @entity1286 @entity207 @entity1443 @entity110 @entity2021
INTRODUCTION: The unexpected appearance of acute @entity110 during the course of drug treatment gives rise to the following question: is it an @entity56 @entity110 (due to an immediate @entity56 : IgE mediated specific immunity) or is it pseudo- @entity56 ? We report our findings in an immuno-allergological study of @entity1 who were sent for @entity1931 which presented as immediate hypersensivity ( @entity110 , angiooedema, @entity2021 ). METHODS: A prospective study was conducted including all the @entity1 who were sent to the unit for @entity110 or angiooedema type @entity1931 . @entity1 were questioned about previous chronic @entity110 and also about @entity110 after taking different medicines. The clinical examination looked for a dermographism. All the @entity1 then took skin tests for immediate @entity56 , the molecule was contra-indicated and tests for cross-reactivity were conducted. @entity1 : Three hundred fifty @entity1 were sent to this unit between February 2000 and April 2001 for @entity1931 , mostly with @entity110 /angiooedema but in 7 cases with @entity2021 . The incriminated drugs were varied: 50 p. 100 were due mainly to penicillins and @entity2886 . Other drug groups were also involved: non @entity134 anti-inflammatories, @entity117 and @entity1443 for the most part, along with local anesthetics, @entity1286 -based products, contrast @entity1496 products, corticosteroids. RESULTS: Of the 350 @entity1 tested, only 22 were @entity56 and had positive tests for the incriminated drug. In these 22 @entity1 , with the exception of 2 of them, the effects were severe ( @entity2021 in 7 @entity1 ) and the @entity110 was only a minor manifestation of the reaction. The drugs responsible were cephalosporin (10 @entity1 ), the penicillin (6 @entity1 ), @entity2690 (2 @entity1 ), gonadorelin (1 @entity1 ), carboxymethylcellulose (1 @entity1 ), lidocain (1 @entity1 ), and @entity207 (1 @entity1 ). The 328 other @entity1 had negative tests and were able to retake the tested molecule without incident. Most of them had antecedents of chronic @entity110 or dermographism. DISCUSSION: Only 22 @entity1 of the 350, i.e. 6 p. 100 were genuinely @entity56 . These @entity1 were those who presented the most severe symptoms. The other @entity1 , i.e. the majority, suffered from pseudo- @entity56 drug-induced @entity110 , which made retaking the medicines possible.
