Parasite molecules and host responses in XXXX .

@entity1 @entity8434 @entity12047
UNASSIGNED: @entity8434 is the infection by the larvae of cestode parasites belonging to the @entity12047 sensu lato species complex. Local host responses are strikingly subdued in relation to the size and persistence of these larvae, which develop within @entity1 organs as "hydatid cysts" measuring up to tens of cm in diameter. In a context in which helminth-derived immune-suppressive, as well as Th2-inducing, molecules garner much interest, knowledge on the interactions between @entity12047 molecules and the immune system lags behind. Here we discuss what is known and what are the open questions on @entity12047 molecules and structures interacting with the innate and adaptive immune systems, potentially or in demonstrated form. We attempt a global biological approach on molecules that have been given consideration primarily as protective (Eg95) or diagnostic antigens (antigen B, antigen 5). We integrate glycobiological information, which traverses the discussions on antigen 5, the mucin-based protective laminated layer and immunologically active preparations from protoscoleces. We also highlight some less well known molecules that appear as promising candidates to possess immune-regulatory activities. Finally, we point out gaps in the molecular-level knowledge of this infectious agent that hinder our understanding of its immunology. This article is protected by copyright. All rights reserved.
