Primary radiation therapy in the treatment of XXXX .

@entity1 @entity957 @entity5 @entity66
From 1970 to 1986, 45 @entity1 received primary radiation therapy for @entity957 at the University of California Los Angeles (UCLA) Center for the Health Sciences and Wadsworth Veteran's Administration Hospital. Seven @entity1 were lost to follow-up or had prior irradiation, and were excluded. Thirty-eight @entity1 received a median dose of 70 Gy (62.5 to 80 Gy) to the primary site. After a median follow-up of 48 months, initial control of disease at the primary site was accomplished in 74% of the @entity1 . The initial control by stage was as follows: TI, 83%, T2, 67%; and T3, 63%. After surgical salvage, local control increased to 92%, 80% and 75% for stages T1, T2, and T3, respectively. Twenty-nine percent (11 of 38) of the @entity1 had cervical node metastases at presentation. Radiation provided regional control in 96% (26 of 27) with @entity66 and 86% (six of seven) with N1 disease at diagnosis. Sixteen @entity1 (42%) had an additional malignancy of the upper aerodigestive tract. Because the incidence of second @entity5 after treatment is high and surgical salvage of treatment failures is possible, close follow-up is essential in the management of this @entity5 . We conclude that radiation therapy is an effective modality for the treatment of @entity957 . Primary radiation therapy may offer many @entity1 the chance to avoid surgical procedures that are both cosmetically and functionally debilitating without compromosing treatment outcome.
