Analysis of @entity5689 and Phosphoinositol-3 Kinase expression in primary XXXX .

@entity6459 @entity2880 @entity5 @entity2279 @entity5689 @entity2184 @entity13634 @entity10412 @entity3 @entity3895
BACKGROUND: To evaluate the regulation of blood supply in primary @entity2184 through @entity5689 ( @entity3895 -1)/Phosphoinositol-3 Kinase ( @entity10412 ). METHODS: The expression of @entity3895 -1 and @entity10412 was analyzed in 51 paraffin sections of metastatic (n   =   30) and non-metastastic @entity2184 (n   =   21). Two trained observers quantified @entity3895 -1 and @entity10412 immunfluorecensce expression by determining intensity of staining and percentage of positive cells. The expression was correlated with known prognostic factors. Besides angiogenesis by means of @entity6459 expression, the normal vasculature ( @entity2880 Factor expression) were evaluated semi-quantitatively. Vasculogenic mimicry (VM) was analyzed by @entity2279 /PAS staining. RESULTS: All examined specimens expressed @entity3895 -1 with a mean of 90.34 % @entity3895 -1 positive cells (range, 3.23-100%). @entity3 was associated with a higher @entity3895 -1 expression. The correlation of @entity3895 -1 with well-established prognostic factors showed a significant association between @entity3895 -1 expression and largest @entity5 diameter (p   =   0.022), @entity13634 -classification (p   =   0.008), and invasion of optic nerve head (p   =   0.048). @entity10412 was expressed by all @entity2184 with a mean of 87.28% cells showing @entity10412 expression. A higher level of @entity10412 was significantly associated with larger height (p   =   0.042) and progressed TNM-stage (p   =   0.016). The percentage of @entity10412 and @entity3895 -1 positive cells were significantly associated (p   =   0.034). For @entity10412 and @entity3895 -1 expression a non-significant association with VM was shown (p   =   0.064 and p   =   0.072, respectively). No correlation of @entity10412 or @entity3895 -1 with angiogenesis or mature vasculature was seen (p   >   0.05). CONCLUSIONS: @entity3895 -1 expression may be especially up-regulated in larger @entity2184 . As it was correlated with @entity10412 expression and VM in this series of @entity2184 , @entity3895 -1 might induce the formation of VM via the @entity10412 -signalling cascade. This article is protected by copyright. All rights reserved.
