Effect of preemptive topical @entity3522 on XXXX relief after photorefractive keratectomy.

@entity1 @entity3522 @entity735 @entity158 @entity282
PURPOSE: To assess the prophylactic effect of preoperative application of topical @entity3522 on @entity282 control in @entity1 having photorefractive keratectomy (PRK). SETTING: Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN: Randomized masked clinical trial. METHODS: In this @entity735 , @entity1 having bilateral PRK received 1 drop of @entity3522 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each @entity1 ) received topical @entity3522 every 6 hours for 2 days. One day and 2 days postoperatively, @entity1 were asked to rate the perceived @entity158 in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses. RESULTS: All 70 @entity1 (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, @entity1 reported @entity158 scores that were clinically and statistically significantly lower in the eyes pretreated with @entity3522 than in the fellow eyes (0.97 versus 2.09) (P=.018). @entity158 scores at 2 days did not differ significantly (P=.877). CONCLUSION: Administration of a single drop of topical @entity3522 0.1% 2 hours before PRK seemed to increase the efficacy of @entity282 management in a clinically and statistically significant manner. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
