Bone structure and turnover in XXXX .

@entity1 @entity1472 @entity174 @entity6 @entity79
SUMMARY: We compared skeletal parameters in type 2 @entity6 (T2DM) and non- @entity6 postmenopausal @entity1 . Bone structure by dual energy x-ray absorptiometry (DXA) and HR-pQCT was not different, although procollagen type 1 @entity1472 -terminal propeptide (P1NP) and osteocalcin levels were lower in T2DM. INTRODUCTION: T2DM is associated with increased @entity174 risk, but, paradoxically, with higher cross-sectional bone density (BMD) as measured by DXA. We sought explanations to this puzzle by investigating detailed structural and biochemical skeletal parameters in T2DM. METHODS: Cross-sectional comparison of 25 postmenopausal T2DM @entity1 and 25 matched controls using DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT) and biochemical bone turnover markers. RESULTS: BMD by DXA did not differ between T2DM and controls. HR-pQCT assessment also did not differ, with the exception of cortical area at the tibia, which tended to be lower in the diabetics (difference of 12        6 [mean    SD] mm, p   =   0.06). P1NP and osteocalcin levels were lower in T2DM as compared to controls (P1NP, 34.3        16 vs. 57.3        28 ng/ml; p   =   0.005; osteocalcin, 4.5        2 vs. 6.2        2 nmol/L; p   =   0.001). CONCLUSIONS: Postmenopausal @entity1 with T2DM had lower levels of bone formation markers as compared to controls. Aside from a possible decrease in cortical bone area at a weight-bearing site, bone structure was not altered in T2DM. @entity79 may be a skeletal parameter that is present in T2DM.
