Meal timing dominates the lighting regimen as a synchronizer of the circadian blood @entity1068 clearance rate rhythm in XXXX .

@entity35 @entity1068 @entity17323
The effects of timing of a single daily meal on the circadian rhythm of blood @entity1068 clearance rates were investigated in two groups of @entity35 maintained on opposite 12 hours light: 12 hours dark (LD) schedules. Initially, the @entity35 were fed ad libitum. Then feeding was restricted to 4 mid-light (ML) hours for one group and 4 @entity17323 ( @entity17323 ) hours for the other. Finally, the meal timing was reversed; the ML-fed group became the @entity17323 -fed group and vice versa. Following acclimatization to each of the 3 feeding regimens, blood @entity1068 clearance @entity35 ere determined for subgroups (n - 8) of both groups injected (i.p.) with @entity1068 at 5 times during 24-hour spans. The LD schedule synchronized the clearance rate rhythm during ad libitum feeding. Although the rhythm persisted without significant amplitude changes during restricted feeding regimens, minimal clearance rates during ML and @entity17323 feeding approximately the time of food presentation, with maximal rates 8-12 hours later. This relationship remained constant with the feeding phases were reversed. Thus, when food availability is limited, the single daily mean dominates the lighting regimen as synchronizer of the circadian blood @entity1068 clearance rate rhythm.
