Survival analysis following resection of AJCC XXXX based on different combinations of T and N stages.

@entity1 @entity5 @entity1600 @entity3 @entity1086 @entity204
BACKGROUNDS/AIMS: According to 7th AJCC TNM staging system, @entity1086 ( @entity1086 ) with @entity1600 ( @entity1600 ) @entity3 is classified as N1 or N2; thus making the stage IIIB (N1) or IVB (N2). Stage IIIB consists of N1 status with wide coverage of T1-3, but T3N1 group often showed poorer outcomes than T1-2N1 groups. This study intended to assess post-resection prognosis of T3N1 versus other stage III subgroups. METHODS: We selected 103 @entity1 from our institutional database of @entity1086 who underwent R0 resection between July 1996 and June 2009 and whose @entity1086 was confined to stage T3N0, T1-3N1 or T1-3N2. These @entity1 were stratified into five groups, namely, T3N0 (n=26), T1N1 (n=13), T2N1 (n=35), T3N1 (n=20) and T1-3N2 (n=9), and were followed for >= 5 years or until @entity204 . RESULTS: Surgical procedures were minor liver resection (n=53), minor liver resection with bile duct resection (n=23), major liver resection (n=12), major liver resection with bile duct resection (n=5), and hepatopancreatoduodenectomy (n=12). Mean follow-up period was 57.2  68.5 months. Overall 5-year survival rate based on all-cause @entity204 and @entity5 , respectively, was 57.7% and 60.6% in T3N0, 15.4% and 15.4% in T1N1 (n=13), 28.6% and 28.6% in T2N1 (n=35), 5.0% and 5.7% in T3N1 (n=20), and 22.2% and 22.2% in T1-3N2. The survival outcome of T3N1 group was the poorest among the four stage III groups and was comparable to that of stage IVB (p=0.53). CONCLUSIONS: The prognosis of T3N1 @entity1086 is unusually poor even after R0 resection, thus we suggest extensive @entity1600 may be necessary in @entity1 with T3 @entity5 for accurate prognostic evaluation and radical removal of potential nodal micrometastasis. Further validation of this result is necessary in large @entity1 populations from multiple centers.
