Hyperbaric XXXX pretreatment attenuates hepatic reperfusion injury.

@entity63 @entity19 @entity26 @entity1234 @entity35 @entity99 @entity1865 @entity855
Microcirculatory derangement, energy depletion and lipid peroxidation have been related to development of @entity63 -reperfusion @entity99 . This study investigates the effects of hyperbaric @entity26 (HBO) on @entity99 -reperfusion injury. Adult, male @entity35 were used. Three groups were evaluated: 1) sham-operated control (laparotomy only, no @entity63 , no HBO), n=8; 2) @entity63 control (1-h @entity63 , 2-h reperfusion, no HBO), n=8; and 3) HBO pretreatment (100%, @entity26 , 2.5 atm absolute, 90 min) plus @entity63 (1-h @entity63 , 2-h reperfusion), n=8. An in vivo microscope was used to investigate hepatic microcirculation. Tissue @entity1234 ( @entity1865 ) and @entity855 ( @entity855 ) were determined. In comparison with the @entity63 control group, HBO significantly improved harmful insults following @entity63 -reperfusion. HBO lessened adherent leukocyte count (6.00+/-1.31 cells/200 microm vs 11. @entity19 .88 cells/200 microm), and improved flow velocity (1.72+/-0.26 mm/s vs 0.83+/-0.19 mm/s) in post-sinusoidal venules. HBO also reduced @entity1865 (1.04+/-0.24 nmol/mg protein vs 2.24+/-0.49 micromol/g protein), and increased @entity855 (2.03+/-0.17 micromol/g wet wt vs 0.73+/-0.11 micromol/g wet wt) levels. This study demonstrates that HBO before @entity63 may ameliorate the @entity63 -reperfusion @entity99 in the @entity35 model.
