Locomotor damage and brain XXXX induced by lead exposure are attenuated by @entity11676 treatment.

@entity72623 @entity66 @entity4968 @entity12609 @entity35 @entity6738 @entity1098 @entity11676
We investigated the antioxidant potential of @entity11676 (GA), a natural compound found in vegetal sources, on the motor and oxidative damages induced by lead. @entity35 exposed to lead (50 mg/kg, i.p., once a day, 5 days) were treated with GA (13.5mg/kg, p.o.) or @entity1098 (110 mg/kg, i.p.) daily, for 3 days. Lead exposure decreased the locomotor and exploratory activities, reduced blood @entity72623 activity, and increased brain @entity12609 (CAT) activity without altering other antioxidant defenses. Brain @entity66 ( @entity66 ) estimated by lipid peroxidation (TBARS) and protein @entity6738 were increased by lead. GA reversed the motor behavior parameters, the @entity72623 activity, as well as the markers of @entity66 changed by lead exposure. CAT activity remained high, possibly as a compensatory mechanism to eliminate hydroperoxides during lead @entity4968 . @entity1098 , a conventional chelating agent, was not beneficial on the lead-induced motor behavior and oxidative damages. Both GA (less) and @entity1098 (more) reduced the lead accumulation in brain tissue. Negative correlations were observed between the behavioral parameters and lipid peroxidation and the lead levels in brain tissue. In conclusion, GA may be an adjuvant in lead exposure, mainly by its antioxidant properties against the motor and oxidative damages resulting from such @entity4968 .
