Evaluation of single-photon emission tomography imaging of supratentorial brain gliomas with XXXX sestamibi.

@entity1 @entity1136 @entity64 @entity706 @entity39 @entity75 @entity11 @entity867
Single-photon emission tomography (SPET) with @entity1136 sestamibi (MIBI) was carried out in 61 adult @entity1 with supratentorial expanding @entity75 . Thirty-one @entity1 had pathologically proven @entity11 . Ten @entity1 had pathologically proven @entity11 , while another 12 @entity1 had a clinical diagnosis of @entity11 . The other eight @entity1 had a variety of lesions including radiation @entity39 (3), abscess (2), @entity64 (2) and primary @entity706 (1). SPET was performed 15 min after administration of 740-930 MBq MIBI and transverse, sagittal and coronal views were reconstructed. Using computed tomography or magnetic resonance imaging guidance, a MIBI uptake index was computed as the ratio of counts in the lesion to counts in the contralateral homologous region. In high-grade @entity11 , the MIBI index ranged from 1.9 to 6.6 (mean 3.6 +/- 1.4) whereas it ranged from 0.8 to 1.7 (1.1 +/- 0.2) in the pathologically proven low-grade group (P < 0.01). No significant difference was found between the two low-grade groups (1.1 +/- 0.2 vs 1.1 +/- 0.2). No overlap was found between high-grade and @entity11 index values. @entity1 with suspected radiation @entity39 , @entity867 or @entity64 did not demonstrate high MIBI uptake (0.9-2.2), whereas one @entity1 with @entity706 did (3.9). This study suggests that MIBI SPET imaging is of value in distinguishing low-from high-grade supratentorial @entity11 in adults.
