Glucocorticoid receptors in immunological subtypes of childhood XXXX cells: a Pediatric Oncology Group Study.

@entity1 @entity981 @entity1619 @entity3052 @entity1778 @entity8624
Glucocorticoid receptors were quantitated by a whole cell method in cells from 593 @entity1 with @entity3052 at the time of diagnosis. @entity1778 cells were also immunologically typed and divided into early pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-negative), pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-positive), B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-positive), and T- (reactive with antibodies to T-lymphocyte antigens) subtypes. There was a median of 9.7 X 10(3) sites per cell in the 359 with early pre-B- @entity981 , a median of 8.1 X 10(3) sites per cell from 103 @entity1 with @entity8624 , and a median of 4.0 X 10(3) sites per cell from 116 @entity1 with @entity1619 . The distributions per cell were significantly different among these 3 groups (P less than 0.0001). The 15 @entity1 with B-cell disease had a median of 3.2 X 10(3) sites per cell. At the time of analysis, remission induction data are available for most of these @entity1 . Within the early pre-B- group 291 @entity1 with a median receptor number of 9.9 X 10(3) achieved remission, while 13 with a median receptor number of 4.8 X 10(3) did not. These distributions were significantly different (P = 0.034). Within the pre-B- and T-cell groups the distributions of receptor numbers for responders and non-responders were not significantly different. We conclude that each immunological subtype has characteristic receptor distribution. High receptor number within the null group is associated with the ability of the @entity1 to achieve remission; however, the range of values within each @entity1 group is too broad to use this assay as a predictor of response for any individual @entity1 .
