Treatment with endotracheal therapeutics after @entity4834 microinstillation inhalation exposure increases blood cholinesterase levels in XXXX .

@entity5591 @entity410 @entity137 @entity859 @entity71976 @entity3045 @entity840 @entity52464 @entity12935 @entity358 @entity64276 @entity35415 @entity4834 @entity9966 @entity11015 @entity5595
@entity12935 ( @entity12935 ) and @entity64276 ( @entity64276 ) activities were measured in the blood and tissues of animals that are treated with a number of endotracheally aerosolized therapeutics for protection against inhalation @entity137 to @entity4834 . Therapeutics included, aerosolized @entity9966 ( @entity11015 ), @entity5591 or combination of @entity11015 with @entity3045 , @entity5595 , keratinocyte growth factor, @entity859 A1 receptor antisense oligonucleotide ( @entity52464 ), @entity71976 (2,3 DABA), oxycyte, and survanta. @entity840 exposed to 677.4   mg/m(3) or 846.5   mg/m(3) (1.2 LCt(50)) @entity4834 for 4   min using a microinstillation inhalation exposure technique and treated 1   min later with the aerosolized therapeutics. Treatment with all therapeutics significantly increased the survival rate with no @entity410 throughout the 24   h study period. Blood @entity12935 activity determined using @entity35415 as substrate showed 20% activity remaining in @entity4834 -exposed animals compare to controls. In aerosolized @entity11015 and @entity5591 -treated animals the remaining @entity12935 activity was significantly higher (45-60%) compared to @entity4834 -exposed animals (p   <   0.05). Similarly, treatment with all the combination therapeutics resulted in significant increase in blood @entity12935 activity in comparison to @entity4834 -exposed animals although the increases varied between treatments (p   <   0.05). @entity64276 activity was increased after treatment with aerosolized therapeutics but was lesser in magnitude compared to @entity12935 activity changes. Various tissues showed elevated @entity12935 activity after therapeutic treatment of @entity4834 -exposed animals. Increased @entity12935 and @entity64276 activities in animals treated with nasal therapeutics suggest that enhanced breathing and reduced @entity358 possibly contribute to rapid normalization of chemical warfare nerve agent inhibited cholinesterases.
