Clinical behavior and a contemporary management algorithm for prepubertal XXXX : a summary of the Prepubertal Testis Tumor Registry.

@entity1 @entity5 @entity2970 @entity160 @entity44
PURPOSE: The Prepubertal Testis Tumor Registry was established by the Urologic Section of the American Academy of Pediatrics in 1980 to record data on a large number of prepubertal @entity5 regarding presentation, treatment and outcome to define appropriate management better. We reviewed the registry data in the context of other modern studies to elucidate the appropriate management of these rare @entity5 . MATERIALS AND METHODS: Relevant data in the prepubertal @entity5 registry were tabulated and analyzed. RESULTS: There were 395 prepubertal @entity1 who had a primary @entity5 . Generally @entity5 accounted for 38% of cases. A significant proportion of @entity5 were benign regardless of @entity1 age. @entity160 levels for @entity1 with benign and @entity5 overlapped in @entity1 younger than 6 months. Of the @entity1 with @entity2970 80% presented with stage 1 disease and overall survival was excellent. There were no metastases or deaths among the @entity1 with @entity44 . Of all @entity1 with @entity5 metastases developed in only 1. CONCLUSIONS: We recommend initial excisional biopsy for all amenable prepubertal @entity5 , except those with an @entity160 level that is clearly increased for @entity1 age. @entity1 with @entity5 may be released from oncological followup. @entity1 with stage I @entity2970 should be monitored closely, and those with recurrent or metastatic @entity2970 should be treated with chemotherapy. Retroperitoneal lymph node dissection is reserved for @entity1 with recurrent retroperitoneal masses following chemotherapy. Aggressive treatment of metastatic Sertoli cell or undifferentiated @entity5 is warranted.
