Cumulative effect of risk factors on short-term surgical success of XXXX augmented trabeculectomy.

@entity1 @entity1138 @entity726 @entity1139 @entity134 @entity2297
CONTEXT: Risk factors for failure of trabeculectomy may have a cumulative effect on the outcome. AIMS: To study the effect of preoperative ocular risk factors on the surgical outcome of trabeculectomy augmented with 2 commonly used doses of @entity1138 . SETTINGS AND DESIGN: In a prospective cohort study, cases were recruited over an 18 month period. 92 eyes of 83 @entity1 with one to three known risk factors for failure of trabeculectomy underwent @entity1138 ( @entity1139 ) augmented trabeculectomy. METHODS AND MATERIAL: Trabeculectomy was done with a randomly chosen @entity1139 dose of 0.2 mg/ml or 0.4 mg/ml. All cases were followed up for a period of at least 3 months. Surgical success was defined as the lowering of intraocular pressure (IOP) below 21 mmHg during the follow up period. STATISTICAL ANALYSIS USED: Chi square test, paired t test, odds ratio, effect size. RESULTS: Eyes with two or three risk factors (out of @entity726 , failed trabeculectomy, @entity2297 , post @entity726 , @entity726 , adherent leucoma, @entity726 , prolonged medical therapy, @entity134 induced @entity726 , post penetrating @entity726 and @entity726 ) had a significantly poorer surgical success rate (88% and 78%) than eyes with one risk factor (100%). 0.4 mg/ml @entity1139 used sub-sclerally had a statistically similar effect on lowering the IOP as 0.2 mg/ml in all groups. The rate of complications was significantly higher in the 0.4 mg/ml subgroup. CONCLUSIONS: The presence of more than one preoperative ocular risk factor, affects the surgical success of @entity1139 augmented trabeculectomy in high-risk cases. Because of the significantly higher rate of complications with the higher dose of @entity1139 , this should be used sparingly, only in cases with more than two risk factors.
