Neonatal exposure to the D1 agonist XXXX inhibits pair bonding in the adult prairie vole.

@entity11640 @entity10095 @entity12174 @entity146 @entity935 @entity73 @entity245 @entity2344
The monogamous prairie @entity245 to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal @entity935 system are not well characterized. This study examined whether early manipulation of the @entity935 system, a known mediator of adult prairie vole social behavior, during neonatal development would affect adult aggressive and @entity146 . Eight-day-old pups were given a single treatment with either 1 mg/kg of @entity2344 (D1 agonist), @entity11640 (D2 agonist), @entity10095 (D1 antagonist), @entity12174 (D2 antagonist), or saline vehicle. As adults, animals received tests for @entity146 and partner preference. Activation of D1-like receptors in @entity73 partner preference formation, but had no effect on aggression. Other neonatal treatments had no effect on their behavior as adults. To determine whether D1 activation in pups induced changes in @entity935 receptor expression, we performed autoradiography on striatal tissue from a second cohort of saline-treated and @entity2344 -treated animals. Although sex differences were observed, we found no treatment differences in D1 or D2 receptor binding in any striatal subregion. This study shows that exposure to a single early pharmacological alteration of @entity935 receptor activity may have long-term effects on the social behavior of prairie voles.
