An observational study of XXXX induced sedation and its pharmacological management.

@entity1 @entity1088 @entity30182 @entity1770 @entity25
UNASSIGNED: @entity1088 induced sedation is common but its management is unclear. We analyzed the factors associated with @entity1088 -induced sedation and the efficacy of common pharmacological strategies. We conducted a naturalistic observational study using two years electronic records of a cohort @entity1 and three analyses: a cross sectional analysis of factors associated with total number of hours slept (as an objective proxy of sedation), and two prospective analyses of which factors were associated with changes in hours slept and the efficacy of two pharmacological strategies. 133 @entity1 were included, of which 64.7% slept at least 9h daily. Among monotherapy @entity1 (n=30), only @entity30182 levels (r=.367, p=.03) correlated with hours slept. Using the prospective cohort (n=107), 42 @entity1 decreased the number of hours slept, due to decreasing @entity1088 (40%) or augmenting with @entity1770 (36%). These two strategies were recommended to 22 (20.6%) and 23 (21.5%) subjects respectively but the majority (81.8% and 73.9%) did not reduce number of hours slept. Thus, pharmacological and non-pharmacological factors are involved in sedation. @entity30182 plasma levels correlated with @entity25 . Reducing @entity1088 and @entity1770 augmentation were associated to amelioration of sedation, although both strategies were effective only in a limited numbers of subjects.
