A retrospective immunohistochemical and clinicopathological study of XXXX of the urinary tract.

@entity1 @entity4153 @entity3507 @entity5 @entity1606 @entity3508 @entity2277 @entity3
BACKGROUND: To investigate the immunohistochemical and clinicopathological behaviors of primary @entity4153 ( @entity4153 ). METHODS: A retrospective study of 10 cases of urinary tract SCC (7 @entity1 and 3 @entity1 , average age, 54; range, 35-78 years) at Chang Gung Memorial Hospital is reported. Among these cases, 3 @entity5 arose from the kidney, 2 from the renal pelvis, 2 from the ureter, and 3 from the bladder. Clinical and follow-up data were obtained. Histological and immunohistochemical studies with antibodies to neuroendocrine (NE) markers were conducted. RESULTS: The most prominent common feature of the 10 @entity4153 was their cell histopathology: small to medium-sized round to spindle-shaped cells with scanty cytoplasm, hyperchromatic nuclei, and inconspicuous nucleoli. Immunostaining revealed positive @entity3508 ( @entity3508 ) reactivity in 10 of 10 @entity5 , but there was focal and weak staining for @entity3507 ( @entity3507 ) in 4 of 10 @entity5 . The 7 @entity1 with @entity2277 -positive @entity4153 all developed metastatic lesions, and 5 of them expired within 1 year. CONCLUSIONS: @entity4153 of the urinary tract system share similar histopathological features and NE markers with their pulmonary counterpart. @entity3508 was expressed more consistently than @entity3507 in these @entity5 . However, the preferential expression of @entity3508 and intensity of immunostaining of these 2 NE markers did not predict the clinical outcome of these @entity1 . The presence of both @entity1606 or SCC alone did not foretell the clinical outcome either. @entity1 with the presence of @entity2277 in the @entity5 tissues appeared to have poorer prognoses with early @entity3 and mortality.
