Reduction of XXXX + T cell subsets involved in incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

@entity1 @entity404 @entity39 @entity5 @entity2533 @entity403 @entity1199 @entity405
UNASSIGNED: @entity403 + T cells ( @entity404 + Tregs and @entity405 + Treg) have been demonstrated to play roles in the maintenance of tolerance after allogeneic hematopoietic stem cell transplantation (Allo-HSCT). We have found that @entity403 + y  TCR+ Treg cells (y  Tregs) exerted regulatory functions. In the current study, @entity1 were recruited and divided as non-cGVHD, limited cGVHD and extensive cGVHD groups. Healthy volunteers were recruited as healthy group. Treg cells were evaluated by flow cytometry. Serum cytokine levels of @entity1199 , @entity5 @entity39 factor-a, interferon-y and transforming growth factor-b1 ( @entity2533 ) were evaluated by ELISA. The results showed that percentages of @entity404 + Tregs, @entity405 + Tregs and y  Tregs were all significantly increased in non-cGVHD group compared with those in healthy group, limited cGVHD group and extensive cGVHD group. Moreover, compared with extensive cGVHD group, percentages of these three types of Tregs were significantly increased in limited cGVHD group. The levels of @entity2533 increased dramatically in non-cGVHD group compared with other groups. Spearman's correlation analysis revealed that the increased levels of @entity2533 and @entity1199 were positively associated with increased Treg subsets, indicating that @entity2533 and @entity1199 participated in the expansion process of @entity403 + Tregs in vivo. Our findings support that increasing the number of Tregs following allo-HSCT would be a preferential strategy for controlling cGVHD. Copyright    2015 John Wiley _ Sons, Ltd.
