Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator XXXX in Post-Lung Transplant Primary Graft Dysfunction Risk.

@entity1 @entity52249 @entity2289 @entity72351 @entity651 @entity813
UNASSIGNED: The authors previously identified plasma @entity2289 ( @entity2289 ) level as a quantitative @entity651 biomarker in @entity813 ( @entity813 ). They hypothesized that plasma levels of @entity2289 used as a quantitative trait could facilitate discovery of genetic loci important in @entity813 pathogenesis. A two-stage cohort study was performed. In stage 1, they tested associations of loci with @entity2289 plasma level using linear modeling. Genotyping was performed using the Illumina CVD Bead Chip v2. Loci meeting a p < 5   *   10(-4) cutoff were carried forward and tested in stage 2 for association with @entity813 . Two hundred ninety-seven enrollees were evaluated in stage 1. Six loci, associated with @entity2289 , were carried forward to stage 2 and evaluated in 728 @entity1 . @entity72351 ( @entity52249 [ @entity52249 ]) was significantly associated with @entity813 (p   =   0.006). The increased risk of @entity813 for carrying at least one copy of this variant was 11.7% (95% confidence interval 4.9-18.5%). The false-positive rate for individuals with this genotype who did not have @entity813 was 6.1%. Variants in the @entity52249 gene are associated with higher circulating @entity2289 plasma levels and validate for association with clinical @entity813 . A protein quantitative trait analysis for @entity813 risk prioritizes genetic variations in @entity52249 and supports a role for Toll-like receptors in @entity813 pathogenesis.
