Cell proliferation-associated proteins in XXXX , including papillary serous and endometrioid subtypes.

@entity1 @entity1204 @entity10610 @entity1364 @entity1377 @entity5 @entity8189 @entity8780 @entity7596 @entity54232 @entity4348
Cyclin dependent kinases (cdks) and cyclins regulate the progression of cells through the cell cycle and can be overexpressed in @entity1 @entity5 . The purpose of this study was to evaluate the immunohistochemical profile of these proliferation-associated proteins and correlate the results with clinicopathologic parameters of @entity1204 . Archival tissue sections from 91 @entity1204 were immunostained using monoclonal antibodies against @entity10610 cdk, @entity54232 , @entity8780 , Ki-67, and @entity1364 . Immunoreactivity was semiquantitatively assessed and the results correlated with pathologic features and survival. Of the 91 @entity1204 , 74 were endometrioid (17 villoglandular, 57 of usual type) and 17 were @entity1377 . The positivity rates for the different proteins in papillary serous and endometrioid @entity5 , respectively, were as follows: @entity10610 , 24% and 23%; @entity7596 , 71% and 64%; @entity8189 , 24% and 26%; @entity8780 , 47% and 9%; Ki-67, 82% and 64%; and @entity1364 , 47% and 47%. Only @entity8780 correlated with histologic @entity5 type with significantly higher expression in both @entity1377 compared to nonvilloglandular @entity4348 (p = 0.0001). @entity8780 positivity also correlated with advanced @entity5 stage (p = 0.0001). Ki-67, @entity7596 , and @entity1364 correlated with @entity1 survival in @entity4348 on univariate analysis (p = 0.01, 0.02, and 0.003, respectively), but, on multivariate analysis, only @entity5 grade (p = 0.02) and depth of invasion (p = 0.04) were independent predictors of outcome. In summary, although most of the cell proliferation-associated proteins studied did not appear to be associated with clinicopathologic features of @entity1204 , there was significantly higher expression of @entity8780 in @entity1377 compared to nonvilloglandular @entity4348 , suggesting a possible role of @entity8780 in @entity5 behavior. In addition, Ki-67, @entity7596 , and @entity1364 expression correlated with survival in @entity4348 , but only in a univariate analysis.
