Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with XXXX .

@entity1 @entity1552 @entity8111 @entity70558 @entity70557 @entity70553 @entity70555 @entity34189 @entity2843 @entity70560 @entity439 @entity70559 @entity70554 @entity70556 @entity438
BACKGROUND AND PURPOSE: Remodeling of the extracellular matrix seems to be a crucial event in the pathogenesis of @entity438 . Matrix metalloproteinases are the most important degrading enzymes in the extracellular matrix. Their activity is controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). To investigate the possible impact of genetic variants within the genes encoding @entity34189 , we conducted this case-control study. METHODS: A study sample was analyzed that comprised 44 @entity1 with @entity438 and 44, 41, and 40 controls for the analysis of @entity34189 , respectively. Differences in genotype and allele frequencies of identified polymorphisms were determined. The entire coding regions and parts of the promoter sequences of the @entity34189 genes were with using the automated laser fluorescence technique. RESULTS: Nine polymorphisms were identified, 3 located in @entity2843 ( @entity70553 , @entity70554 , @entity70555 ), 4 in @entity1552 ( @entity70556 , @entity70557 , @entity70558 , @entity70559 ), and 2 in @entity8111 ( @entity70560 , @entity70554 ), whereas @entity70556 , @entity70557 , and @entity70558 of the @entity1552 gene are newly identified polymorphisms. We detected no deviation from Hardy-Weinberg equilibrium in any of the groups. The C allele of the @entity70555 polymorphism was more frequently found in female than in male controls (exact nominal P=0.0012). However, this finding could not be validated by analysis of a second sample of 113 controls (exact nominal P=1.0000). There were no differences in genotype and allele frequencies between any of the other groups. CONCLUSIONS: Our analysis of the entire coding region of 3 TIMPs, which are the main inhibitors of metalloproteinase activity in the extracellular matrix, failed to show an association between genetic polymorphisms and an @entity438 . These data do not support the hypothesis that genetic variants within these genes have an impact on @entity439 development in the white population.
