Brain and XXXX in @entity15 . Correlation between MRI parameters, clinical subtypes and symptoms.

@entity1 @entity2504 @entity66 @entity75 @entity602 @entity15
We investigated various magnetic resonance MRI parameters for both brain and spinal cord to see if any improved the clinicoradiological correlation in @entity15 . Ninety-one @entity15 @entity1 (28 relapsing-remitting, 32 secondary progressive and 31 primary progressive) were imaged using conventional T1, proton density- and T2-weighted MRI of the brain and spinal cord. Focal brain and spinal cord lesion load was scored, as were @entity66 , brain ventricular volume and spinal cord cross-sectional area. Clinical measures included the expanded disability status scale (EDSS), the functional systems score and a dedicated urology complaint questionnaire. Secondary progressive @entity1 differed from relapsing-remitting and primary progressive @entity1 by a larger number of hypointense T1 lesions in the @entity2504 and @entity602 . Primary progressive @entity1 more often had @entity66 in the brain and/or spinal cord than did relapsing-remitting and secondary progressive @entity1 . In the entire study population, EDSS correlated with both brain and spinal cord MRI parameters, which were independent. The urological complaint score correlated only with spinal cord MRI parameters. In relapsing-remitting and secondary progressive @entity15 , the correlation between MRI and clinical parameters was better than in the entire population. In this subgroup EDSS variance could be explained best by T1 @entity75 load, ventricle volume and spinal cord cross-sectional area. In the primary progressive subgroup the clinicoradiological correlation was weak for brain parameters but was present between @entity602 and spinal cord MRI parameters. In conclusion, the different brain and spinal cord MRI parameters currently available revealed considerable heterogeneity between clinical subtypes of @entity15 . In relapsing-remitting and secondary progressive @entity15 both brain and spinal cord MRI may provide a tool for monitoring @entity1 , while in primary progressive @entity15 the clinicoradiological correlation is weak for brain imaging.
