Trace element concentration in primary XXXX --a systematic review.

@entity1 @entity96 @entity4259 @entity219 @entity920 @entity157 @entity68
BACKGROUND: The incidence of primary @entity96 varies between countries. Many of the etiological factors contributing to the geographical variations in incidence are unknown. Development of @entity157 has been linked to levels of trace elements. This review summarizes the evidence associating @entity157 with trace elements. METHODS: MEDLINE, EMBASE, and CENTRAL databases were searched. Various inclusion and exclusion criteria were applied to select the articles for inclusion. Data extraction was performed using a custom designed data extraction form. RESULTS: A total of 12,344 references were identified. Duplicates, 1,597, were excluded. Clearly irrelevant references, 10,676, were excluded through reading titles and abstracts. Some references (59) were excluded by applying the exclusion criteria. Twelve studies including 646 @entity1 and measuring @entity68 content (8), @entity920 content (11), @entity219 (9), and @entity4259 (2) qualified for the review. Although a meta-analysis was not possible due to heterogeneity between the studies, a clear pattern of distribution of the trace elements was discernible. CONCLUSION: @entity68 and @entity219 content are lower in @entity157 than in surrounding tissues or normal controls. @entity920 content is lower in @entity157 than in surrounding tissues and cirrhotic controls. Epidemiological and physiological reasons for the trace element alterations should be further investigated.
