Prevalence of and Risk Factors for Intracranial XXXX .

@entity1 @entity410 @entity341 @entity1504 @entity854
BACKGROUND AND OBJECTIVES: Prospective data are lacking to determine which @entity1 might benefit from prompt neuroimaging after unprovoked @entity410 . We aimed to determine the prevalence of, and risk factors for, relevant @entity1504 in @entity1 with first, unprovoked @entity410 . METHODS: We conducted a 6-center prospective study in @entity1 aged >28 days to 18 years with seemingly unprovoked @entity410 . @entity341 ( @entity341 ) clinicians documented clinical findings on a standardized form. Our main outcome was the presence of a clinically relevant intracranial abnormality on computed tomography (CT) or MRI, defined as those that might change management, either emergently, urgently, or nonurgently. RESULTS: We enrolled 475 of 625 (76%) eligible @entity1 . Of 354 @entity1 for whom cranial MRI or CT scans were obtained in the @entity341 or within 4 months of the @entity341 visit, 40 (11.3%; 95% confidence interval [CI]: 8.0-14.6%) had clinically relevant @entity1504 , with 3 (0.8%; 95% CI: 0.1-1.8%) having emergent/urgent abnormalities. On logistic regression analysis, a high-risk past medical history (adjusted odds ratio: 9.2; 95% CI: 2.4-35.7) and any focal aspect to the @entity410 (odds ratio: 2.5; 95% CI: 1.2-5.3) were independently associated with clinically @entity854 . CONCLUSIONS: Clinically relevant @entity1504 occur in 11% of @entity1 with first, unprovoked @entity410 . Emergent/urgent abnormalities, however, occur in <1%, suggesting that most @entity1 do not require neuroimaging in the @entity341 . Findings on @entity1 history and physical examination identify @entity1 at higher risk of @entity854 .
