Dose-response relationship in XXXX .

@entity7227 @entity840 @entity3304 @entity34039 @entity272
The dose-response relationship (challenge phase) of the @entity272 response was investigated in previously sensitized Hartley @entity840 . Larger numbers of animals were used per group at the lower doses so that statistically significant observations could be made. Model compounds known to be skin sensitizers were used: a strong sensitizer, @entity3304 ( @entity3304 ), and a weaker sensitizer, @entity7227 ( @entity34039 ). A gradation in response to changing @entity3304 doses was easily observed by using either the open epicutaneous test (OET) or the Buehler occlusive patch test. The Buehler test was used to study the dose-response relationship of @entity3304 sensitization. The sensitivity of the OET and Buehler test was judged not adequate to measure the dose response for @entity34039 , because at high doses a high incidence of responders was not obtained. Therefore, the maximization test was used to evaluate @entity34039 . Similar, non-linear dose-response curves were obtained with each compound. The higher doses produced a somewhat linear relationship, but at lower doses the curves flattened out and more slowly approached a zero response. Thus, for potent sensitizers, concentrations found in exposure situations might be in the linear portion of the dose-response curve. For weak responders, use concentrations might be in the shallow portion of the curve, where reactions would be underestimated if a linear dose-response curve were assumed.
