Cost of persistent XXXX in Italy.

@entity1 @entity565 @entity748
BACKGROUND: Asthma is a common disease of the airways with a significant burden for the society and for @entity1 ' quality of life. The Social Impact of Respiratory Integrated Outcomes (SIRIO) study estimated a mean cost of 1,177.40     per @entity1 /year in Italy, in 2007. The aim of the present study was to update the cost of persistent @entity565 @entity1 in Italy. METHODS: An observational, retrospective, bottom-up analysis was carried out starting from the data base operating in the Lung Unit of the Specialist Medical Centre (CEMS), Verona (Italy), over the period June 2013-December 2015. @entity1 ' data were recorded over the 12        2  months before the enrollment and during 12        2  months of follow-up. The prospective was the Italian National Health Service and the broad Italian society. Clinical data were measured in terms of forced expiratory volume in 1  s (FEV1%) and number of relapses. Healthcare resources (namely; number of hospitalizations and/or ER admissions; number of visits; drug use and duration, and indirect costs) were recorded. RESULTS: The cohort consisted of 817 @entity1 with persistent @entity565 of different severity. They had a 42.96% male prevalence; a mean (  SE) age of 49.06 (  0.64) years; a mean 87.47% (  0.81) FEV1% pred. in baseline, and 69.16% of subjects had comorbidities. The mean (  SE) number of relapses was 0.91 (  0.09) per @entity1 /year before the enrolment. After 12  months, FEV1% significantly improved by +6.31% (  0.45) from the corresponding baseline value (p    <   0.001). The number of relapses decreased of -0.46 (  0.09) (p    <   0.001). The estimated total annual cost per @entity748 @entity1 was 1,183.14     (  65.79    ) during the 12  months before the enrolment, and 1,290.89     (  68.74    ) throughout the follow-up. The increase was mostly due to the significantly increased duration of therapeutic strategies. The costs of hospitalization, general practitioner and rescue medications were significantly decreased. CONCLUSIONS: The periodic update of cost analysis is a key to monitor the trend of main @entity565 outcomes and related expenditure over time. It allows to plan the most convenient actions in terms of prevention strategies and effective interventions, with the aim of optimizing the healthcare resources consumption and maximizing the impact on clinical outcomes and @entity1 ' quality of life. The role of an appropriate pharmacological strategy still proves crucial in minimizing @entity565 morbidity and the corresponding socio-economic impact.
