Bone marrow aspirations and lumbar punctures in XXXX at diagnosis: correlation with IRSS staging.

@entity1 @entity3 @entity995
BACKGROUND: Few studies have suggested that routine bone marrow (BM) and cerebrospinal fluid (CSF) evaluation is not needed in all @entity1 with @entity995 . Although the International @entity995 Staging System was developed recently, there remain no clear stage-specific guidelines with regard to the need for BM and CSF evaluations as part of the metastatic workup for @entity1 with @entity995 . METHODS: This is a retrospective study analyzing results of CSF cytology and BM evaluation at presentation/diagnosis in @entity1 with @entity995 registered at our center from June, 2003 to June, 2009. Only cases with both BM biopsy and lumbar puncture were included. RESULTS: Of the 259 evaluable @entity1 , 18 (7%) were positive for @entity3 either in CSF and/or BM. Although 7 of these had overt @entity3 at presentation (stage IV), 1 belonged to stage II and 10 to stage IIIa. No stage 0 or I @entity1 tested positive despite presence of histopathologic high-risk factors. CONCLUSIONS: This is the largest study evaluating the role of metastatic workup in @entity1 with @entity995 at presentation. We conclude that CSF and BM evaluation is not required in @entity1 with stage 0 and I @entity995 at presentation. No definitive recommendation could be made for stage II @entity1 ; while stage III and IV @entity1 must certainly be evaluated.
