Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of XXXX .

@entity5 @entity1 @entity788 @entity1124
BACKGROUND: Serological proinflammatory markers such as C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been associated with reduced survival for many different types of @entity5 . This study determined the prognostic value of the preoperative value of these markers in @entity1 with resectable @entity788 . METHODS: Consecutive @entity1 who underwent pancreaticoduodenectomy for @entity1124 were entered into our database from 2001 to the present day. CRP, NLR, and PLR at the time of presentation were recorded as well as overall and disease-free survival. RESULTS: Seventy-four @entity1 were identified. Overall median survival was 35.0 months and median disease-free survival was 27.0 months. Follow-up ranged from 1 to 125.8 months. Preoperative NLR was significantly greater in those @entity1 who developed recurrence in the follow-up period (4.5 vs. 3.1). CRP and PLR were not found to differ significantly between the two groups. Kaplan-Meier survival analysis of @entity1 with NLR > 5 demonstrated a disease-free survival of 12 months compared with 52 months for those @entity1 with NLR < 5 (p < 0.001). CONCLUSION: Preoperative NLR offers important prognostic information regarding disease-free survival following curative resection of @entity1124 .
