National Lupus Hospitalization Trends Reveal Rising Rates of Herpes Zoster and Declines in XXXX .

@entity1 @entity2803 @entity10592 @entity55 @entity1252 @entity364 @entity1292 @entity166 @entity2259
OBJECTIVE: Infection is a leading cause of morbidity and mortality in @entity1252 ( @entity1252 ). Therapeutic practices have evolved over the past 15 years, but effects on @entity166 of @entity1252 are unknown. We evaluated trends in hospitalizations for severe and @entity1292 in a population-based @entity1252 study. METHODS: Data derive from the 2000 to 2011 United States National Inpatient Sample, including individuals who met a validated administrative definition of @entity1252 . Primary outcomes were diagnoses of @entity2259 , @entity55 , opportunistic @entity364 , @entity2803 , or @entity10592 ( @entity10592 ). We used Poisson regression to determine whether infection rates were changing in @entity1252 hospitalizations and used predictive marginals to generate annual adjusted rates of specific infections. RESULTS: We identified 361,337 @entity1252 hospitalizations from 2000 to 2011 meeting study inclusion criteria. Compared to non- @entity1252 hospitalizations, @entity1252 @entity1 were younger (51 vs. 62 years), predominantly female (89% vs. 54%), and more likely to be racial/ethnic minorities. @entity1252 diagnosis was significantly associated with all measured severe and @entity1292 . From 2000 to 2011, adjusted @entity1252 hospitalization rates for herpes zoster increased more than non- @entity1252 rates: 54 to 79 per 10,000 @entity1252 hospitalizations compared with 24 to 29 per 10,000 non- @entity1252 hospitalizations. Conversely, @entity1252 hospitalizations for @entity10592 disproportionately decreased: 5.1 to 2.5 per 10,000 @entity1252 hospitalizations compared with 0.9 to 1.3 per 10,000 non- @entity1252 hospitalizations. CONCLUSIONS: Among @entity1 with @entity1252 , herpes zoster hospitalizations are rising while @entity10592 hospitalizations are declining. These trends likely reflect evolving @entity1252 treatment strategies. Further research is needed to identify @entity1 at greatest risk for @entity166 .
