Invasive XXXX in Phramongkutklao Hospital 2004-2008: clinical data, serotype distribution and antimicrobial resistance patterns.

@entity1 @entity66 @entity55 @entity114 @entity693 @entity3524 @entity2259
OBJECTIVE: To describe the clinical course, serotype distribution and antimicrobial resistance patterns of invasive @entity66 (IPD) cases in a public hospital. MATERIAL AND METHOD: Retrospective review of IPD cases occurring from January 2004 through December 2008 was performed. Antibiotic susceptibility testing and serotyping were performed for available isolates. RESULTS: Fifty one IPD cases occurred during the study period, of which 47 had medical records available for review. The majority of cases occurred among @entity1 under 5 years of age (23.4%) and adults over 60 years of age (36.1%). Underlying diseases were identified in 72.3% of @entity1 . Fifty-three percent of cases were associated with @entity55 , while 17% had @entity693 , and 15% had @entity2259 . Serotype could be determined for 15 (31.9%) isolates, and 6B was most common. Based on current antibiotic susceptibility breakpoints for @entity693 , 4 of the 7 available isolates from @entity693 cases were @entity114 resistant and one had reduced susceptibility to @entity3524 . Among @entity693 isolates, 96.7% were @entity114 susceptible and 3.3% had intermediate susceptibility to @entity114 . Overall case fatality proportion was 19%. CONCLUSION: At this tertiary care hospital in Bangkok, IPD has disproportionately affected young @entity1 and the elderly. High rates of @entity114 resistance among @entity693 cases, the most severe form of IPD, underscore the need of appropriate treatment strategies and vaccine usage.
