INHIBITORY EFFECT OF XXXX ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST.

@entity108 @entity19316 @entity25962 @entity1976 @entity5 @entity2310 @entity107 @entity5906 @entity21077 @entity8312 @entity3929 @entity880 @entity35 @entity157
@entity157 ( @entity157 ) is the fifth most common @entity5 . An important approach to control @entity157 is chemoprevention. This study aims at investigating the antitumor effect of @entity19316 ( @entity8312 ). @entity35 were injected with @entity107 ( @entity108 ) to establish @entity157 . Tumor development was observed. Liver function was evaluated. Apoptosis and cell cycle arrest-related makers and signaling cascades were determined by Western blot, RT-PCR and flow cytometric analysis. The administration of @entity8312 could significantly inhibit @entity5 development in @entity108 -induced @entity157 @entity35 , shown by reduced incidence of @entity5 , decreased number of @entity5 nodules and reduced maximal size of @entity5 . @entity108 -induced increase of @entity5906 aminotransferase, @entity3929 aminotransferase, @entity880 dehydrogenase and alkaline phosphatase activities were significantly inhibited by @entity8312 . @entity8312 exhibited inhibitory effect on @entity157 through induction of apoptosis and cell cycle arrest in @entity35 . @entity8312 induced apoptosis through increasing @entity2310 , decreasing @entity1976 , increasing the release of cytochrome c, and activating caspase, which consisted of the mitochondrial apoptotic pathway. @entity8312 induced G2/M cell cycle arrest through down-regulation of @entity25962 / @entity21077 . In addition, inhibition of Akt and ERK signaling and the antioxidant activities of @entity8312 may also contribute to its antitumor effect. These data provide new insight into the mechanisms underlying the antitumor effect of @entity8312 .
