The systemic and local acute phase response following XXXX .

@entity1545 @entity15370 @entity131 @entity1024 @entity32 @entity75 @entity19 @entity635 @entity693 @entity143
It is not known whether @entity131 results in a systemic acute phase response (APR) or whether an APR influences outcome after an insult to the CNS. The present study sought to establish whether @entity1545 elicits a systemic or local APR. The expression of @entity15370 ( @entity15370 ) mRNA in liver and brain tissues was measured by Taqman reverse transcriptase-polymerase chain reaction after an excitotoxic lesion in the striatum or challenge with a proinflammatory cytokine. @entity1024 ( @entity143 )-induced @entity75 did not elicit a systemic APR. In contrast, proinflammatory challenge with @entity19 recombinant @entity635 (mrIL-1beta) resulted in a significant hepatic @entity15370 mRNA expression within 6 hours. Thus, an inflammatory challenge that results in a @entity693 leads to a hepatic APR, whereas @entity131 alone, with no evidence of a @entity693 , does not produce an APR. This is surprising because @entity143 leads to an increase in endogenous @entity635 synthesis. This suggests that the brain has an endogenous antiinflammatory mechanism, which protects against the spread of @entity32 after an acute injury. In the brain, both @entity75 and proinflammatory challenge resulted in a profound parenchymal upregulation of @entity15370 mRNA after 6 and 12 hours in the injected hemisphere. These results suggest that the local APR may play a role as an antiinflammatory mechanism. These findings indicate a potentially pivotal role for peripheral and local @entity15370 production on outcome after @entity1545 .
