Cyclooxygenase-2 expression and angiogenesis in XXXX --association with polyp size.

@entity1 @entity1127 @entity7 @entity5 @entity3009 @entity14 @entity2247 @entity2880
BACKGROUND: @entity2247 is the rate-limiting enzyme in @entity3009 synthesis, and plays an important role in @entity5 enlargement. @entity2247 is expressed in @entity1 gastric and @entity14 , and the expression increases in a @entity5 size-dependent manner. In the present study, we attempted to examine the @entity2247 expression pattern in @entity1127 , a non-tumorous lesion. @entity1 AND METHODS: Fifty-eight @entity1127 , obtained by endoscopic polypectomy, were immunostained with anti- @entity2247 and antivascular endothelial growth factor ( @entity7 ) antibodies. Microvessel density (MVD) was determined by @entity2880 factor immunostaining. RESULTS: In larger @entity1127 , @entity2247 was expressed mainly on the luminal side of the @entity1127 , while it was absent in smaller @entity1127 . A significant correlation between @entity2247 immunoreactivity and polyp size was observed (p < 0.01). High @entity7 expression and MVD were observed mainly in the same stromal region of the @entity1127 where @entity2247 was expressed. Both @entity7 expression and MVD were also correlated with polyp size significantly (ps < 0.01). CONCLUSIONS: @entity2247 expression increased in a size-dependent manner in non-tumorous @entity1127 , suggesting that @entity2247 expression is not necessarily linked to epithelial cell transformation. Moreover, @entity2247 may participate in polyp enlargement through angiogenesis by promoting @entity7 production.
