Craniofacial surgery for XXXX : report of an international collaborative study.

@entity1 @entity2122 @entity5 @entity957 @entity260 @entity420
BACKGROUND: @entity5 of the skull base are rare. Therefore, no single center treats enough @entity1 to accumulate significant numbers for meaningful analysis of outcomes after @entity2122 ( @entity2122 ). The current report was based on a large cohort that was analyzed retrospectively by an International Collaborative Study Group. METHODS: One thousand three hundred seven @entity1 who underwent @entity2122 in 17 institutions were analyzable for outcome. The median age was 54 years (range, 1-98 years). Definitive treatment prior to @entity2122 had been administered in 59% of @entity1 and included radiotherapy in 367 @entity1 (28%), chemotherapy in 151 @entity1 (12%), and surgery in 523 @entity1 (40%). The majority of @entity5 (87%) involved the anterior cranial fossa. @entity957 (29%) and @entity420 (16%) were the most common histologic types. The margins of surgical resection were reported close/positive in 412 @entity1 (32%). Adjuvant postoperative radiotherapy was received by 510 @entity1 (39%), and chemotherapy was received by 57 @entity1 (4%). RESULTS: @entity260 were reported in 433 @entity1 (33%), with local wound complications the most common (18%). The postoperative mortality rate was 4%. With a median follow-up of 25 months, the 5-year overall, disease-specific, and recurrence-free survival rates were 54%, 60%, and 53%, respectively. The histology of the @entity5 , its intracranial extent, and the status of surgical margins were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. CONCLUSIONS: @entity2122 is a safe and effective treatment option for @entity1 with @entity5 . The histology of the @entity5 , its intracranial extent, and the status of surgical margins are independent determinants of outcome.
