Apoptotic and anti-angiogenic effects of Salvia triloba extract in XXXX cell lines.

@entity1552 @entity137 @entity522 @entity263 @entity5737 @entity7 @entity5 @entity1243 @entity442 @entity18974 @entity540 @entity687 @entity2843 @entity9205 @entity7741
UNASSIGNED: Plants, due to their remarkable composition, are considered as natural resources of bioactive compounds with specific biological activities. Salvia genus (Lamiaceae) has been used around the world in complementary medicine since ancient times. We investigated the cytotoxic, apoptotic and anti-angiogenic effects of methanolic Salvia triloba extract (STE) in @entity263 cells. Cell viability was evaluated by XTT; apoptosis was investigated by DNA fragmentation and @entity522 /7 activity assays. Changes in the angiogenic cytokine levels were investigated by human angiogenesis antibody array. Scratch assay was used to determine the cell motility. STE induced @entity137 and apoptosis in a concentration-dependent manner in both @entity5 cells; however, it was not cytotoxic to normal cells. Cell motility was reduced in PC-3, DU-145 and HUVEC cells by STE treatment. @entity7741 , @entity18974 , @entity540 , EGF, @entity442 and @entity9205 levels were significantly decreased by -2.9, -3.7, -1.7, -1.7, -2.0 and -1.8 fold in STE-treated DU-145 cells, however, @entity7741 , @entity687 , @entity1243 , @entity5737 , @entity2843 , @entity1552 and @entity7 levels were significantly decreased by -5.1, -2.0, -2.4, -3.1, -1.5, -2.0 and -2.5 fold in PC-3 cells. These data suggest that STE might be a promising candidate for anti- @entity5 and anti-angiogenic treatment of @entity263 .
