The Use and Abuse of Transcranial Magnetic Stimulation to Modulate Corticospinal Excitability in XXXX .

@entity1 @entity9808
UNASSIGNED: The magnitude and direction of reported physiological effects induced using @entity9808 ( @entity9808 ) to modulate @entity1 motor cortical excitability have proven difficult to replicate routinely. We conducted an online survey on the prevalence and possible causes of these reproducibility issues. A total of 153 researchers were identified via their publications and invited to complete an anonymous internet-based survey that asked about their experience trying to reproduce published findings for various @entity9808 protocols. The prevalence of questionable research practices known to contribute to low reproducibility was also determined. We received 47 completed surveys from researchers with an average of 16.4 published papers (95% CI 10.8-22.0) that used @entity9808 to modulate motor cortical excitability. Respondents also had a mean of 4.0 (2.5-5.7) relevant completed studies that would never be published. Across a range of @entity9808 protocols, 45-60% of respondents found similar results to those in the original publications; the other respondents were able to reproduce the original effects only sometimes or not at all. Only 20% of respondents used formal power calculations to determine study sample sizes. Others relied on previously published studies (25%), personal experience (24%) or flexible post-hoc criteria (41%). Approximately 44% of respondents knew researchers who engaged in questionable research practices (range 32-70%), yet only 18% admitted to engaging in them (range 6-38%). These practices included screening subjects to find those that respond in a desired way to a @entity9808 protocol, selectively reporting results and rejecting data based on a gut feeling. In a sample of 56 published papers that were inspected, not a single questionable research practice was reported. Our survey revealed that approximately 50% of researchers are unable to reproduce published @entity9808 effects. Researchers need to start increasing study sample size and eliminating-or at least reporting-questionable research practices in order to make the outcomes of @entity9808 research reproducible.
