Exposure to XXXX in adolescence improves the working memory and @entity148 -like behavior of adult female @entity35 with intrauterine growth restriction, independently of hippocampal neurogenesis.

@entity6100 @entity1603 @entity132 @entity2404 @entity146 @entity2141 @entity1592 @entity2819 @entity148 @entity35 @entity2414
UNASSIGNED: @entity1592 ( @entity1592 ) is a risk factor for @entity2414 and @entity132 during growth and adulthood. However, this risk might be modulated by environmental factors during development. Here we examined whether exposing adolescent male and female @entity35 with @entity2404 -induced @entity1592 to @entity6100 ( @entity6100 ) affected their working memory and @entity148 -like behavior in adulthood. We also used @entity1603 staining to investigate hippocampal cellular proliferation and @entity1603 and @entity2141 double staining to investigate neural differentiation in female @entity1592 @entity35 . In the absence of adolescent stress, @entity1592 female @entity35 , but not male @entity35 , scored significantly lower in the T-maze test of working memory and exhibited higher @entity148 -like behavior in the elevated-plus maze test compared with controls. Adolescent exposure to @entity6100 abolished these @entity146 in @entity1592 females. In the absence of adolescent stress, hippocampal cellular proliferation was significantly higher in @entity1592 females than in non- @entity1592 female controls and was not influenced by adolescent exposure to @entity6100 . Hippocampal neural differentiation was equivalent in non-stressed control and @entity1592 females. Neural differentiation was significantly increased by adolescent exposure to @entity6100 in controls but not in @entity1592 females. There was no significant difference in the serum @entity2819 concentrations between non-stressed control and @entity1592 females; however, adolescent exposure to @entity6100 significantly increased serum @entity2819 concentration in control females but not in @entity1592 females. These results demonstrate that adolescent exposure to @entity6100 improves @entity146 independent of hippocampal neurogenesis in adult @entity35 with @entity1592 .
