Comparative effectiveness of XXXX and botulinum for the treatment of essential voice @entity400 .

@entity1169 @entity1 @entity400 @entity7364
OBJECTIVES/HYPOTHESIS: To assess the comparative effectiveness of botulinum toxin and @entity1169 in @entity1 with @entity400 ( @entity400 ). STUDY DESIGN: Individual prospective cohort study. METHODS: Study @entity1 were recruited at the Emory Voice Center from @entity1 seeking treatment for @entity400 . Exclusion criteria included current b-blocker treatment, @entity7364 , or other disease that prevented the use of @entity1169 therapy. A 10-week washout period from prior botulinum toxin treatment occurred before enrollment. @entity1 were assessed via the Voice-Related Quality-Of-Life (VRQOL) questionnaire, Quality of life in @entity400 , and blinded perceptual voice assessment. These assessments were made at baseline voice 2 weeks after @entity1169 therapy and 4 weeks after botulinum toxin injection. RESULTS: Eighteen @entity1 were enrolled. After 2 to 4 weeks of @entity1169 therapy (with a maximum dosage of 60 mg to 90 mg per day), @entity1 report an average   VRQOL of 9.31. Six @entity1 report significant VRQOL improvement >10, with the rest reporting changes between -7.5 and 7.5. Fifteen @entity1 were followed for at least 4 weeks after botulinum toxin injection, reporting an average improvement in scaled VRQOL of 22.00. Blinded perceptual voice assessment demonstrates an improvement in overall severity of @entity400 with botulinum toxin. CONCLUSIONS: In some @entity1 with @entity400 , @entity1169 led to significant vocal improvement with no major side effects. Although botulinum toxin remains the gold-standard therapy for @entity1 with @entity400 , @entity1169 represents a possible alternative or adjuvant therapy for certain @entity1 .
