A retrospective analysis of treatment-related hospitalization costs of pediatric, adolescent, and young adult XXXX .

@entity1 @entity1398 @entity981 @entity5
UNASSIGNED: This retrospective study examined the longitudinal hospital outcomes (costs adjusted for inflation, hospital days, and admissions) associated with the treatment of pediatric, adolescent, and young adult @entity981 ( @entity981 ). @entity1 between one and 26  years of age with newly diagnosed @entity981 , who were treated at Primary @entity1 's Hospital (PCH) in Salt Lake City, Utah were included. Treatment and hospitalization data were retrieved from system-wide @entity5 registry and enterprise data warehouse. PCH is a member of the @entity1 's Oncology Group (COG) and @entity1 were treated on, or according to, active COG protocols. Treatment-related hospital costs of @entity981 were examined by computing the average annual growth rates (AAGR). Longitudinal regressions identified @entity1 characteristics associated with costs. A total of 505 @entity1 (46.9% female) were included. The majority of @entity1 had B-cell lineage @entity981 , 6.7% had @entity981 , and the median age at diagnosis was 4  years. Per- @entity1 , first-year @entity981 hospitalization costs at PCH rose from  24,197 in 1998 to  37,924 in 2012. The AAGRs were 6.1, 13.0, and 7.6% for total, pharmacy, and room and care costs, respectively. Average days (AAGR  =  5.2%) and admissions (AAGR  =  3.8%) also demonstrated an increasing trend. High-risk @entity1 had 47% higher costs per 6-month period in the first 5  years from diagnosis than standard-risk @entity1 (P  <  0.001). Similarly, relapsed @entity981 and stem cell transplantations were associated with significantly higher costs than nonrelapsed and no transplantations, respectively (P  <  0.001). Increasing treatment-related costs of @entity981 demonstrate an area for further investigation. Value-based interventions such as identifying low-risk fever and @entity1398 @entity1 and managing them in outpatient settings should be evaluated for reducing the hospital burden of @entity981 .
