XXXX ( @entity3008 ): examining oral contraceptive pills and the onset of disease.

@entity1 @entity172 @entity358 @entity3008 @entity393
BACKGROUND: @entity3008 ( @entity3008 ) is a rare @entity358 of @entity1 of unknown etiology. Diffuse cystic changes associated with multifocal clusters of smooth muscle-like cells ( @entity3008 cells) replace normal lung parenchyma, leading to progressive @entity393 . Reports of exacerbations of @entity3008 with the use of exogenous @entity172 and during pregnancy suggest an association between hormones and clinical deterioration. OBJECTIVES: To conduct the largest case series to date in order to characterize the demographics of a living cohort of @entity1 with @entity3008 . To evaluate the effect of oral contraceptive pill (OCPs) use on the age at onset of symptoms in a large population of @entity1 with @entity3008 . METHODS: The study population was drawn from the University of Miami (UM) @entity3008 database consisting of 91 living @entity1 previously diagnosed with @entity3008 by a physician. A self-administered questionnaire was mailed to the @entity1 . RESULTS: The final response rate was 91.2% (83 of 91), and the study @entity1 were 96.4% white, 1.2% Asian, 1.2% African American, and 1.2% American Indian; 68.4% identified their ethnicity as European and 14.5% as Jewish. Of the @entity1 surveyed, 73 were still menstruating at the time of @entity3008 diagnosis. Among these @entity1 , the rate of use of OCPs was approximately 27%, similar to the rate in the general population. There was a significant difference between the age at onset of symptoms in @entity1 using OCPs vs. @entity1 not using OCPs (29.2 +/- 4.7 vs. 32.9 +/- 8.0, p = 0.0397). CONCLUSIONS: The present study suggests that OCPs may serve as catalysts to promote an earlier occurrence of @entity3008 .
