Predicting complications of pregnancy with first-trimester maternal serum free-betahCG, XXXX and inhibin-A.

@entity1 @entity3152 @entity101 @entity6 @entity14422 @entity15714
OBJECTIVE: To find whether fbetahCG, @entity15714 and inhibin-A levels in maternal serum or fetal nuchal translucency (NT) thickness at the first-trimester screening for trisomy 21 (T21) might detect @entity1 at high risk for adverse pregnancy outcomes. METHODS: A retrospective analysis of 1136 @entity1 with singleton pregnancy between 10 and 14 weeks. @entity1 with @entity14422 were allotted to five subgroups: small for gestational age (SGA), large for gestational age (LGA), gestational @entity6 (GDM), @entity101 , @entity3152 ; @entity1 with normal pregnancy represented the control group. NT, maternal serum fbetahCG, @entity15714 and inhibin-A were measured. Mann-Whitney test was used for the comparison of fbetahCG, @entity15714 , inhibin-A and NT between a subgroup of a certain pregnancy complication and the control group. Multivariate logistic regression models were built to explore the relationship among different variables and the occurrence of @entity14422 . RESULTS: @entity15714 values were significantly lower in @entity1 who delivered SGA babies (n=51, 0.76 MoM; p=0.002) and significantly higher in @entity1 who delivered LGA babies (n=120, 1.12 MoM; p=0.036). In @entity1 with GDM (n=27), fbetahCG, @entity15714 and inhibin-A were insignificantly lower than in controls, whereas in @entity1 with @entity101 (n=56) no significant differences between the groups were found. In @entity1 with a @entity3152 (<34 weeks) (n=17), inhibin-A levels were significantly higher (1.25 MoM; p=0.015). CONCLUSION: Low @entity15714 level is associated with the delivery of an SGA baby and high @entity15714 with the delivery of an LGA baby. High inhibin-A is associated with @entity3152 before 34 weeks. Feto-placental products in the first trimester do not prove to be useful as a screening tool for predicting @entity14422 .
