Effect of ganglion blockade on cerebrospinal fluid XXXX .

@entity3160 @entity235 @entity1854 @entity2647 @entity13673 @entity1338 @entity1063 @entity551
The source of @entity1063 (NE) in CSF has been unclear. It has been suggested that CSF NE indicates central neural noradrenergic tone and is determined differently from plasma NE. If CSF NE depended specifically on NE release in the CNS, then interference with ganglionic neurotransmission would be expected to decrease plasma NE but not CSF NE. @entity551 caused by ganglionic blockade might be expected to increase CSF NE reflexively. We infused the ganglion blocker, @entity13673 , intravenously into anesthetized @entity235 and measured the effects on mean arterial blood pressure (MAP) and on cisterna magna CSF levels of NE. The results were compared with those obtained on administration of saline, @entity1338 (2 micrograms/kg), @entity3160 (0.25 mg/kg), or @entity1854 and with those obtained when @entity551 during ganglion blockade was prevented by concurrent treatment with @entity2647 . @entity13673 decreased MAP by 40%, arterial NE by 64%, and CSF NE by 61%. @entity1854 administered intravenously to produce the same 40% depressor response increased arterial NE by 612% and CSF NE by 155%. Prevention of ganglion blockade-induced @entity551 using @entity2647 did not prevent the decrease in CSF NE caused by @entity13673 , and when @entity2647 was discontinued, the resulting @entity551 was not associated with increases in CSF NE. The similar decreases in plasma NE and CSF NE during ganglionic blockade, and the abolition of reflexive increases in CSF NE during @entity551 in ganglion-blocked subjects, cast doubt on the hypothesis that CSF NE indicates central noradrenergic tone and are consistent instead with at least partial derivation of CSF NE from postganglionic sympathetic nerve endings.
