Metabolic effects of bariatric surgery in XXXX models of circadian disruption.

@entity1 @entity66 @entity28 @entity19 @entity209 @entity413
BACKGROUND/OBJECTIVES: Mounting evidence supports a link between circadian disruption and @entity209 . @entity1 with circadian disruption (for example, night-shift workers) have an increased risk of @entity28 and @entity66 compared with the non-disrupted population. However, it is unclear whether the @entity28 and @entity28 associated with circadian disruption respond to therapeutic treatments as well as individuals with other types of @entity28 . SUBJECTS/METHODS: Here, we test the effectiveness of the commonly used bariatric surgical procedure, Vertical Sleeve Gastrectomy (VSG), in @entity19 models of genetic and environmental circadian disruption. RESULTS: VSG led to a reduction in body weight and fat mass in both Clock(  19) mutant and constant-light @entity19 models (P<0.05), resulting in an overall metabolic improvement independent of circadian disruption. Interestingly, the decrease in body weight occurred without altering diurnal feeding or activity patterns (P>0.05). Within circadian-disrupted models, VSG also led to improved @entity413 tolerance and lipid handling (P<0.05). CONCLUSIONS: Together these data demonstrate that VSG is an effective treatment for the @entity28 associated with circadian disruption, and that the potent effects of bariatric surgery are orthogonal to circadian biology. However, as the effects of bariatric surgery are independent of circadian disruption, VSG cannot be considered a cure for circadian disruption. These data have important implications for circadian-disrupted @entity28 @entity1 . Moreover, these results reveal new information about the metabolic pathways governing the effects of bariatric surgery as well as of circadian disruption.
