Cytokines in fetal blood and XXXX in Rh-immunized pregnancies.

@entity1 @entity650 @entity417 @entity1307 @entity6703 @entity2772 @entity2841
OBJECTIVE: To determine fetal serum and @entity6703 ( @entity6703 ) levels of interleukin (IL)-3, @entity650 , @entity2841 , stem cell factor, and @entity1307 , and to explore the relationship between cytokines and hemoglobin concentration, white blood cell count (WBC), and platelet count in fetuses affected by Rh immunization. METHODS: Thirty-four consecutive Rh-immunized @entity1 in gestational weeks 19-33 were included. All @entity1 were investigated by funipuncture and 13 by amniocentesis. The levels of @entity2772 , @entity650 , @entity2841 , stem cell factor, and @entity1307 were estimated using commercially available immunoassays. RESULTS: There was a significant correlation between @entity1307 concentrations in fetal serum and @entity6703 (r = 0.54, P < .05), whereas none of the other cytokines showed a positive correlation between these two compartments. Fetal serum contained higher concentrations of @entity2772 , @entity2841 , stem cell factor, and @entity1307 compared with @entity6703 . In contrast, the @entity650 level was significantly higher in @entity6703 compared with fetal serum (P = .002). @entity1307 and @entity2772 levels were both negatively correlated with fetal hemoglobin concentrations (r = -0.75, P = .02, and r = -0.67, P = .045). The fetal WBC correlated significantly with the fetal serum concentration of @entity2841 (r = 0.38, P = .04). CONCLUSION: @entity1 fetuses with @entity417 due to erythrocyte immunization exhibit an increased production of @entity1307 and @entity2772 . Other studied cytokines (such as @entity650 ) did not correlate with the degree of @entity417 . Among the studied cytokines, only @entity1307 showed a positive correlation between fetal serum and @entity6703 .
