Longitudinal assessment of XXXX effects on oral word production and symptoms in first-episode @entity161 at acute and stabilized phases.

@entity1 @entity12269 @entity935 @entity75 @entity161 @entity716 @entity2727
BACKGROUND: Some studies have reported @entity716 symptom exacerbation during "pharmacologic challenge" paradigms using @entity935 agonists. Few studies, however, have examined the effects of these agonists on neurocognitive functions in @entity1 with @entity161 . This study assessed the effects of @entity2727 infusion on an oral word production test with demonstrated @entity75 , and on clinical state. METHODS: @entity1 were tested at two different phases; at the onset of their first-episode of @entity161 (acute phase), and then again after they had responded to treatment and were clinically stable (stabilization phase). During each phase, @entity1 were tested prior to and following @entity2727 infusion. Symptom clusters (i.e., positive, negative, and disorganization) were formed from @entity12269 and SADS-C (+PD) ratings at each of these four timepoints. RESULTS: @entity1 produced significantly more words at preinfusion and while stabilized, suggesting that overall, decreased @entity935 activity was associated with better word production. Redundant errors (i.e., perseverations of previously mentioned words and production of multiple words with the same roots) increased significantly following infusion in the stabilized phase. Disorganization symptoms increased significantly following infusion, regardless of study phase. CONCLUSIONS: These findings are consistent with previous theoretical and empirical findings relating @entity935 activity to verbal output, a "redundancy bias" in cognitive control, and exacerbation of disorganization symptoms.
