Humoral regulation of blood flow to choroid plexus: role of XXXX .

@entity6021 @entity5463 @entity95 @entity1951 @entity2647
The goal of this study was to examine humoral mechanisms that regulate blood flow to the choroid plexus. We determined the effects of @entity5463 on blood flow (microspheres) to the choroid plexus in anesthetized and awake @entity95 . In anesthetized @entity95 , blood flow to the choroid plexus was 342 +/- 31 (mean +/- SEM) ml/min/100 g under control conditions. Intravenous infusion of @entity1951 at 4 and 40 mU/kg increased plasma @entity1951 levels from 11 +/- 1 to 55 +/- 15 and 441 +/- 120 pg/ml, respectively, and blood flow to the choroid plexus decreased by 48 +/- 6% and 70 +/- 4%. Cerebral blood flow was not affected by infusion of @entity1951 . Similar responses to infusion of @entity1951 were observed in awake @entity95 . The V1 antagonist [ @entity6021 ] (10 micrograms/kg i.v.) had no effect on resting blood flow, but abolished the effect of @entity1951 on blood flow to the choroid plexus. Vasoconstrictor responses of the choroid plexus to intravenous infusion of @entity2647 were not attenuated by the V1 antagonist. Thus, circulating @entity1951 , at plasma levels that are observed under physiological and pathophysiological conditions, has marked effects on blood flow to the choroid plexus. These effects appear to be mediated through a V1 receptor. We speculate that @entity1951 may play an important role in regulation of blood flow to the choroid plexus and perhaps in the regulation of cerebrospinal fluid production.
