Serum IgG to @entity1457 proteins and @entity2523 gingivalis antigens in @entity6 @entity1 with XXXX .

@entity1 @entity4041 @entity6 @entity1840 @entity2285 @entity1457 @entity1723 @entity2521 @entity367 @entity11217 @entity2523
BACKGROUND: Past studies have reported a correlation between the presence and severity of @entity2521 and serum antibody titers to species-specific antigens of @entity2523 or to cross-reactive antigens, such as lipopolysaccharide (LPS) and @entity1457 proteins (HSP), shared between @entity2523 and other bacteria. Our recent study of periodontal treatment outcome in insulin-dependent (type 1) @entity6 @entity1 with severe @entity2521 (IDDMI/ @entity2521 ) resulted in two key findings: 1. serum @entity367 decarboxylase autoantibody ( @entity1840 Ab) levels were significantly associated with periodontal pocket depth change (PDC) and 2. serum IgG titers to @entity2523 cells were positively associated with @entity1840 Ab level in seropositive ( @entity1840 Ab +) @entity1 . We have therefore hypothesized that profiles of serum autoantibody levels and IgG titers, to P. gingivalis-specific antigens may be useful in assessing risk for @entity2521 in such @entity1 . AIM: To determine whether PDC resulting from non-surgical periodontal treatment can be predicted using profiles of baseline IgG titers to P. gingivalis-specific antigens, @entity1 HSP, and @entity1840 . METHODS: PDC was assessed two months after non-surgical periodontal treatment of 7 @entity1840 Ab + and 11 @entity1840 AbIDDM/ @entity2521 @entity1 . Pretreatment titers to @entity1840 , recombinant @entity1 @entity1457 proteins ( @entity4041 , @entity2285 , and @entity11217 ), and various P. gingivalis antigens were measured using radioligand precipitation or enzyme-linked immunosorbent (ELISA) assays and compared to the same measurements for 154 recent-onset @entity1723 @entity1 and 46 non- @entity6 controls. RESULTS: Median titers (ELISA units) to @entity4041 and @entity2285 were significantly higher than non- @entity6 controls for @entity1840 Ab + (p degrees = 0.002) and @entity1840 Ab- (p = 0.034) @entity1723 / @entity2521 @entity1 , respectively. Multivariate regression analysis indicated significant partial correlation of PDC with log-transformed titers to @entity4041 (r = - 0.62, p = 0.008), @entity2285 (r = + 0.62, p = 0.009), @entity1840 (r = - 0.60, p = 0.01) and @entity2523 LPS (r = - 0.5 1, p = 0.04). Furthermore, hierarchical clustering of baseline profiles of log-transformed @entity4041 , @entity2285 , and @entity1840 Ab titers sorted @entity1 into two distinct clusters with significantly different median PDC (1.45 min, n = 10 vs. 0.65 min, n = 8; p = 0.016, Mann-Whitney). CONCLUSION: Pretreatment profiles of serum antibody titers to @entity4041 , @entity2285 , @entity1840 , and @entity2523 LPS may be useful for predicting which @entity1 with @entity1723 / @entity2521 will have a poor response to non-surgical periodontal therapy.
