Adolescents with @entity12554 have XXXX .

@entity1 @entity455 @entity28 @entity1242 @entity384 @entity12554 @entity774
CONTEXT: @entity1 with @entity774 ( @entity774 ) because of 21-hydroxylase deficiency have multiple vascular risk factors. Young adults with @entity774 have increased intima media thickness, but there have been no studies of vascular function and structure in @entity1 with @entity774 . OBJECTIVE: To establish whether @entity1 with @entity774 have reduced vascular function and increased carotid intima media thickness (cIMT) when compared to healthy and @entity28 @entity1 . DESIGN AND @entity1 : Cross-sectional study of 14 @entity1 (14.8 years    3.2, seven @entity1 ) with @entity12554 compared to 28 @entity28 and 53 healthy controls. MEASUREMENTS: All subjects had assessment of endothelial function flow-mediated dilatation, ( @entity384 ), smooth muscle function @entity1242 dilatation (GTN) and cIMT. Anthropometric data, resting blood pressure and biochemical variables were also measured. RESULTS: @entity774 subjects had significantly reduced @entity384 (4.5    3.0% vs 7.5    5.2%; P = 0.04) and GTN (17.2    1.6% vs 28.4    8.4%; P < 0.001) when compared to controls and the impairment was comparable to the @entity28 cohort. There was no significant difference in cIMT between groups. @entity774 subjects had increased homoeostasis model of assessment-insulin resistance [HOMA-IR 2.5 (0.2-2.9) vs 1.8 (0.5-4.2); P = 0.04], waist-to-height ratio (0.47    0.05 vs 0.44    0.04; P = 0.02) and higher systolic blood pressure Z score (0.29    0.9 vs-0.24    0.64, P = 0.01) compared to healthy controls but not when compared to @entity28 controls. CONCLUSIONS: Subjects with @entity774 have evidence of @entity455 by adolescence.
