Compliance in microcomputer-assisted conventional XXXX therapy: computer simulation study results.

@entity1 @entity6 @entity2690 @entity1735 @entity413
Compliance in @entity6 self-management is a complex issue. It involves the interdependent daily actions of self-measurement of blood @entity413 and adherence to a prescribed schedule of daily activities. This impacts strongly on lifestyle because it necessitates precise meal timing as well as control of size and @entity1735 content. We sought to identify how strongly relaxing the lifestyle constraints per se would impact the ability to achieve improved metabolic control. To isolate these effects from those that result from poor measurement compliance, we used a computer simulator called OMNI et al. Furthermore, to standardize the "clinical" therapy, a second microprocessor device called an " @entity2690 Dosage Computer" was used to adjust @entity2690 doses based on the usual clinical practice of four times a day precibal blood @entity413 measurements. Ten type 1 @entity6 @entity1 were stimulated and each followed for 120 simulated days. In each such subject, the simulation was repeated three times to include three different levels of lifestyle compliance ranging from excellent to poor. In all three protocols, starting from a level of poor control of @entity6 , mean blood @entity413 values were significantly improved without significant differences after 120 days of computer-simulated treatment. Only the standard deviations, expressing the fluctuations of blood @entity413 and hence its stability, increased with decreasing lifestyle compliance. This computer simulation predicts that consistent self-monitoring of four blood @entity413 values per day is the cornerstone of @entity6 self-control and that the use of these data according to a standardized therapeutic algorithm for @entity2690 adjustment may successfully stabilize even @entity1 with poor lifestyle compliance. Clinical studies must follow.
