Unusually High Incidence of Paediatric XXXX in Sweden during the Period 1973 - 2013.

@entity1 @entity7017 @entity66 @entity3082
OBJECTIVE: The prevalence of @entity66 in Sweden during the " @entity3082 period" (1984-1996) was one of the highest in the world. The aim of this study was to assess the @entity66 incidence in our region over the 41-year period, and how diagnostic activity and diagnostic accuracy were affected by the introduction of antibody testing. We also looked into how @entity1 with mild @entity7017 were evaluated. METHODS: In the county of   sterg  tland in Sweden, 2790 paediatric @entity1 were investigated for suspected @entity66 between 1973 and 2013. Notes were scrutinised for data on sex, age, histopathological reports and final diagnosis. For comparative purposes this period was divided into three sub-periods (1973-1983, 1984-1996 and 1997-2013) named pre- @entity3082 , @entity3082 and @entity3082 . RESULTS: @entity66 diagnosis was received by 1,030 @entity1 . The peak incidence rate, 301 cases/100,000 in 1994 for the age group 0-1.9 years is the highest figure ever reported. The other age groups, 2-4.9, 5-14.9, and 15-17.9 years, also had high incidence rates. After the 1984-1996 " @entity3082 period" the incidence decreased for the youngest group but continued to increase for the other groups. The cumulative incidence at 18 years-of-age for @entity1 born during the @entity3082 reached 14 cases/1000 births, the highest figure hitherto reported. Diagnostic activity differed significantly between the three sub-periods (p<0.001) increasing gradually from 1984 and reaching a peak value of 0.87 in 2012. Cases of mild @entity7017 were more frequently regarded as @entity66 cases, decreasing significantly in the " @entity3082 " period (p<0.001). CONCLUSIONS: The incidence rate and cumulative incidence of @entity66 were possibly the highest ever reported. Changes in diagnostic activity and accuracy could not be attributed to the introduction of new antibody tests, possibly because of other changes e.g. variations in the symptoms at presentation and improved knowledge of the disease among parents and health professionals.
