Increase of intracranial pressure after hypothermic XXXX in a chronic porcine model.

@entity1 @entity1707 @entity1545 @entity4798 @entity63 @entity1167 @entity204
OBJECTIVE: An increase in intracranial pressure has been shown to threaten the outcome of @entity1 with @entity63 or traumatic @entity1545 . Its impact on the outcome of @entity1707 undergoing hypothermic @entity1167 has been evaluated in this study. DESIGN: Fifty-six @entity1707 underwent a 75-min period of hypothermic @entity1167 at 20 degrees C. Intracranial pressure, cerebral microdialysis, hemodynamic and metabolic parameters were monitored throughout the experiment. The animals were allowed to survive until the 7th postoperative day and, then, electively killed. RESULTS: The 7-day survival rate was 60.7%, and among survivors, 20 of them (58.8%) developed @entity4798 . A significant increase in intracranial pressure as compared with the baseline level was observed since the end of cooling (p = 0.047) and the difference became larger during all the postoperative intervals (p < 0.0001). Animals that died postoperatively tended to have higher intracranial pressure levels during all the postoperative intervals, but such a difference reached significance only at the 4-h postoperative interval (p = 0.040). The same tendency was observed among animals that survived until the 7th postoperative day and that developed @entity4798 or not, but the difference between these two groups did not reach statistical significance. The animals that died or developed postoperatively @entity4798 had higher intracranial pressure values postoperatively as compared with those that survived without developing @entity4798 and such a difference reached significance at the 2-h (p = 0.015) and 4-h postoperative intervals (p = 0.035). The peak intracranial pressure was 17.2 mmHg (IQR, 13.7-20.8) in animals that died or developed @entity4798 and 14.1 mmHg (IQR, 11.8-16.4) in those that survived 7 days without developing @entity4798 (p = NS). CONCLUSION: Intracranial pressure increases significantly after 75 min of experimental hypothermic @entity1167 and such an increase is associated with a high risk of @entity204 and @entity4798 .
