Acute hypothalamo-pituitary-adrenal axis response to LPS-induced XXXX : expression pattern of kinin type B1 and B2 receptors.

@entity5694 @entity24934 @entity5019 @entity25580 @entity1812 @entity35 @entity4525 @entity774
UNASSIGNED: @entity1812 (BK) and des-Arg9-BK are pro-inflammatory mediators acting via B2 ( @entity24934 ) and @entity25580 ) receptors, respectively. We investigated the role of @entity24934 and @entity25580 in lipopolysaccharide (LPS)-induced @entity774 activation in SD @entity35 . LPS given intraperitoneally (ip) up-regulated @entity25580 mRNA in the hypothalamus, both @entity25580 and @entity24934 were up-regulated in pituitary and adrenal glands. Receptor localization was performed using immunofluorescence staining. @entity25580 was localized in the endothelial cells, nucleus supraopticus ( @entity4525 ), adenohypophysis and adrenal cortex. @entity24934 was localized nucleus paraventricularis (PVN) and @entity4525 , @entity774 . Blockade of @entity25580 prior to LPS further increased ACTH release and blockade of @entity25580 1 h after LPS decreased its release. In addition, we evaluated if blockade of central kinin receptors influence the LPS-induced stimulation of hypothalamic neurons. Blockade of both @entity25580 and @entity24934 reduced the LPS-induced @entity5019 immunoreactivity in the hypothalamus. Our data demonstrate that a single injection of LPS induced a differential expression pattern of kinin @entity25580 and @entity24934 in the @entity774 . The tissue specific cellular localization of these receptors indicates that they may play a crucial role in the maintenance of body homeostasis during @entity5694 .
