The content of free @entity1522 in the stratum corneum is increased in XXXX .

@entity1 @entity6682 @entity1522 @entity195 @entity6248
Xerosis is one of the characteristics of aged skin. Xerosis may be caused by a decrease in the stratum corneum free @entity1522 which are natural moisturizing factors derived from @entity6682 . In aged skin, @entity6682 is immunohistochemically decreased compared with the levels in young skin. However, the differences in stratum corneum @entity1522 between aged and young skin have not been analyzed quantitatively. Therefore, in this study we determined the stratum corneum @entity1522 per 1000 stratum corneum cells in aged and young skin by high-performance liquid chromatography. The amount of @entity6682 mRNA in the epidermis was also compared between aged and young skin using RT-PCR. The total amount of @entity1522 in the stratum corneum was larger in aged @entity195 skin than in young skin. Only a few @entity1522 were found in the stratum corneum of @entity6248 @entity1 (control skin). The expression of @entity6682 mRNA in aged skin was, however, similar to that in young skin. These findings suggest that the immunohistochemical decrease in @entity6682 in aged skin may be caused by promotion of @entity6682 proteolysis in the upper layers of the stratum spinulosum.
