Transient hypercapnic stress causes exaggerated and prolonged elevation of cardiac and renal interstitial norepinephrine levels in conscious XXXX @entity35 .

@entity101 @entity2944 @entity515 @entity1702 @entity35
The responses of sympathetic nerve activity to transient stress can be exaggerated in @entity1702 ( @entity1702 ), @entity101 subjects. Cardiac and renal interstitial norepinephrine (iNE) levels during and after transient @entity2944 were investigated in conscious @entity1702 @entity35 . Dahl @entity1702 and salt-resistant (SR) 6-wk-old @entity35 were fed a high-salt diet, and at 12 wk iNE levels in the heart and kidney were determined using microdialysis with probes inserted in the left ventricular (LV) wall and kidney. A telemetry system determined blood pressure and heart rate (HR) in separate animals. After recovery from the operation, data were collected before, during, and after exposure to normoxic 10% @entity515 for 25 min under unanesthetized conditions. The plasma NE concentrations at baseline did not differ between the two strains. Both cardiac and renal iNE levels were much higher in @entity1702 @entity35 than in SR @entity35 at baseline as well as during hypercapnic stress. After stress, the markedly increased iNE levels of @entity1702 @entity35 were prolonged in the LV as well as in the kidney. During hypercapnic stress, HR decreased in both @entity1702 and SR @entity35 , while sudden increases in HR immediately after the withdrawal from stress were followed by its slower reduction in @entity1702 @entity35 compared with SR @entity35 . In conclusion, transient hypercapnic stress causes exaggerated and prolonged elevation of iNE levels in the heart as well as in kidneys of @entity1702 animals.
