Effects of continuous infusion of @entity4671 at various dose rates on adrenal function in XXXX .

@entity4485 @entity1369 @entity235 @entity1425 @entity701 @entity4671 @entity1063
BACKGROUND: @entity4671 is a commonly used sedative in intravenous anesthesia. The aim of this study was to compare the effects of various @entity4671 doses administered by continuous infusion on adrenal function in @entity235 under general anesthesia. METHODS: Thirty-six healthy adult male @entity235 were randomly divided into six groups. Sodium @entity4485 alone was administered to the control group (group C); five experimental groups (E1, E2, E3, E4, and E5) were also given @entity4671 at doses of 10, 15, 20, 25, and 30   g        kg(-1)        min(-1), respectively, to maintain anesthesia. Heart rate (HR), mean arterial pressure (MAP), and bispectral index (BIS) were monitored. Serum @entity701 , @entity1369 , @entity1425 , and @entity1063 levels were measured, and HR, MAP, and BIS values recorded, before intubation (T0), and at 1  h, 2  h, and 3  h after intubation (T1-3). RESULTS: @entity701 and @entity1369 levels in groups E1-5 decreased as the doses and times of continuous infusion of @entity4671 increased. The @entity701 level was significantly decreased compared with baseline at T3 in group E1 and at T1-3 in groups E2-5 (P   <   0.05). Compared with the corresponding levels in group C, @entity701 levels were significantly lower than T0 values at T3 in group E1 and at T1-3 in groups E2-5 (P   <   0.05). The @entity1369 level was significantly lower at T3 in group E2 and at T1-3 in groups E3-5 (P   <   0.05). Significant reductions in @entity701 levels at T2-3 in group E2 and at T1-3 in groups E3-5 compared with group C were also observed (P   <   0.05). The plasma @entity1425 and @entity1063 levels, HR, MAP, and BIS in groups E1-5 were within the normal range at the different times and with the different doses (P   >   0.05). CONCLUSIONS: @entity701 and @entity1369 levels decreased with time and continuous infusion of @entity4671 ; there were no significant changes in @entity1425 and @entity1063 levels, HR, MAP, and BIS in any group.
