The long-term effects of @entity888 exposure during pre-adolescence on @entity308 -like behaviour in a genetic animal model of XXXX .

@entity308 @entity7865 @entity888 @entity146 @entity73 @entity1316 @entity148 @entity716 @entity35
UNASSIGNED: @entity888 ( @entity7865 ) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include @entity716 , @entity148 and @entity1316 , as well as increased risk of developing a @entity146 later in life. The current study investigated the long-term effects of chronic @entity7865 exposure during pre-adolescence in stress-sensitive Flinders Sensitive Line (FSL) @entity35 (genetic model of @entity308 ) and control Flinders Resistant Line (FRL) @entity35 . @entity7865 or vehicle control was administered twice daily from post-natal day 19 (PostND19) to PostND34, followed by behavioural testing at either PostND35 (early effects) or long-lasting after withdrawal at PostND60 (early adulthood). Animals were evaluated for @entity308 -like behaviour, locomotor activity, social interaction and object recognition memory. @entity7865 reduced @entity308 -like behaviour in both FSL and FRL @entity35 at PostND35, but enhanced this behaviour at PostND60. @entity7865 also reduced locomotor activity on PostND35 in both FSL and FRL @entity35 , but without effect at PostND60. Furthermore, @entity7865 significantly lowered social interaction behaviour (staying together) in both FRL and FSL @entity35 at PostND35 and PostND60, whereas self-grooming time was significantly reduced only at PostND35. @entity7865 treatment enhanced exploration of the familiar vs. novel object in the novel object recognition test (nORT) in FSL and FRL @entity35 on PostND35 and PostND60, indicative of reduced cognitive performance. Thus, early-life @entity7865 exposure induce @entity73 . Lastly, early-life exposure to @entity7865 may result in acute antidepressant-like effects immediately after chronic exposure, whereas long-term effects after withdrawal are depressogenic. Data also supports a role for genetic predisposition as with FSL @entity35 .
