A comparison of XXXX and @entity6513 eye anesthetics.

@entity1 @entity2708 @entity24505 @entity6513 @entity158
OBJECTIVE: To compare two topical eye anesthetics, @entity24505 and @entity6513 , for @entity158 of instillation and duration of activity. METHODS: Volunteers received both anesthetics in a prospective, randomized, double-masked protocol. The subjects were given one drop of a study solution in the lower lid fornix of the left eye. Immediately after receiving the medication, they rated the @entity158 of instillation on a previously validated visual-analog @entity158 scale. This procedure was then repeated in the right eye with the other study solution. @entity158 scales were quantified by making measurements to the nearest millimeter from the point of scale origin to the point marked by the @entity1 . The time interval until return of the corneal blink reflex was determined using a @entity2708 wisp. @entity158 scores and the time to return of corneal reflex were analyzed by the Sign test and Wilcoxon rank-sum test, respectively, with significance defined as p < 0.05. RESULTS: Twenty-three subjects were available for analysis. Twenty subjects reported @entity24505 hurt less than @entity6513 , two felt the @entity158 was the same for the two agents, and only one reported that @entity24505 was more @entity158 . The mean @entity158 score for @entity6513 was 24 mm (100 mm maximum) higher than that for @entity24505 (p < 0.0002). @entity24505 lasted 1.3 minutes longer than @entity6513 , 10.7 minutes versus 9.4 minutes (p = 0.0001). CONCLUSION: @entity24505 eye drops cause less @entity158 than @entity6513 eye drops upon instillation. Anesthesia from @entity24505 last slightly longer. These properties make @entity24505 preferable to @entity6513 .
