The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in exacerbation of XXXX .

@entity1 @entity1030 @entity233 @entity1851
OBJECTIVE: To investigate whether neutrophil-lymphocyte ratio and platelet-lymphocyte ratio like @entity1851 can be used as markers of acute exacerbation in @entity1030 . METHODS: The cross-sectional study was conducted at Konya Training and Research Hospital, Konya, @entity233 , between December 2012 and April 2013, and comprised @entity1 with stable and acute @entity1030 . All @entity1 were male and aged >40 years. @entity1 were included prospectively from outpatient and emergency units according to recent Initiative for @entity1030 2013 criteria. @entity1851 , neutrophil-lymphocyte ratio and platelet-lymphocyte ratio of each group were measured and compared. RESULTS: Of the 94 @entity1 , 48(51%) had stable disease with a mean age of 66.65  10.17 years (range: 49-79 years), and 46(49%) had acute exacerbation with a mean age of 62.67  9.41 years (range: 48-92 years). Mean levels of @entity1851 , neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were 5.04  6.65, 2.75  1.11 and 137.39  65.42 for stable disease, and 57.68  58.49, 7.99  5.72 and 231.18  141.36 for those with acute exacerbation (p=0.001). Cut-off values were neutrophil-lymphocyte ratio =3.3, platelet-lymphocyte ratio =150, and @entity1851 =5 mg/dl. Positive predictive values for @entity1851 , neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were determined as 82% (odds ratio: 27.4); 85% (odds ratio: 32.5); and 73% (odds ratio: 6.3) . Receiver-operating characteristic curve showed a significantly more area under curve of neutrophil-lymphocyte ratio (0.88) compared to platelet-lymphocyte ratio (0.74) (p<0.05). CONCLUSIONS: During acute exacerbations of @entity1030 , neutrophil-lymphocyte ratio may be used as an easily measurable, available and cost-effective parameter with high prognostic accuracy in clinical practice.
