A comparison of the airway response to segmental antigen bronchoprovocation in XXXX and @entity2023 .

@entity1 @entity225 @entity12131 @entity2023 @entity130 @entity565 @entity2490 @entity56 @entity379 @entity1495 @entity112 @entity688 @entity1224
BACKGROUND: @entity1 with @entity56 and those with @entity2023 (without @entity565 ) share many immunopathologic features but differ in the presence of lower airway symptoms in response to antigen. OBJECTIVES: We sought to compare the airway inflammatory response to antigen in @entity1 with @entity12131 and @entity2023 . METHODS: Segmental bronchoprovocation with saline or ragweed antigen was performed in 9 @entity1 with @entity12131 and 9 @entity1 with @entity2023 without @entity565 . The antigen dose used in segmental bronchoprovocation was 10% of the dose that caused a 20% decrease in FEV1 in response to inhalation challenge. Bronchoalveolar lavage (BAL) was performed from the saline- and antigen-challenged segments at 5 minutes and 48 hours after challenge. BAL fluid was analyzed for cell count and differential, distribution of lymphocytes, and concentration of soluble factors ( @entity112 , @entity225 , @entity1495 , tissue inhibitor of metalloproteinase 1, and fibronectin). In addition, BAL cells were cultured ex vivo, and @entity225 , @entity379 , and @entity688 generation was measured. RESULTS: Antigen challenge led to similar patterns of cellular recruitment, mediator levels, and BAL cell cytokine generation in both groups; however, the dose of antigen required to promote comparable responses in the airway was significantly less in @entity1 with @entity565 . CONCLUSION: These data suggest that the pattern of acute airway inflammation in response to allergen does not by itself explain antigen-induced @entity1224 and @entity565 symptoms. We speculate that other factors, such as increased airway sensitivity to allergen or preexisting airway @entity130 , might explain why @entity1 with @entity565 and @entity2490 differ in their clinical and physiologic response to antigen exposure.
