Comparative effects of single dose and repeated oral XXXX administration on indoleamine synthesis and memory functions in @entity35 .

@entity35 @entity5581 @entity2340 @entity750 @entity1130
Brain functions can be affected by the availability of dietary precursors of neurotransmitters. The diet induced increase in @entity2340 (TRP) availability has been shown to increase brain @entity750 ( @entity750 , @entity750 ) synthesis and various related behaviors. A prominent role of @entity750 in memory functions is widely acknowledged. Increased brain @entity750 concentration is shown to enhance cognitive function whereas decreased @entity750 metabolism in brain has been shown to impair memory. This study was designed to investigate the effects of single dose and repeated TRP administration on brain TRP, @entity750 and its metabolite @entity1130 ( @entity5581 ) levels and on memory functions in @entity35 . TRP at a dose of 100 mg/kg body weight were orally administered to @entity35 . Assessment of memory in @entity35 was done using the water maze test (WM). Brain TRP, @entity750 and @entity5581 levels were comparable to control after single TRP administration. Repeated administration of TRP for 6 weeks significantly increased brain TRP (P<0.05), @entity750 (P<0.01) and @entity5581 (P<0.01) levels with respect to controls. Memory enhancement effect of TRP was not seen after single oral administration whereas repeated TRP intake significantly (P<0.01) enhanced memory functions of @entity35 as evidenced by the decreased latency time to reach the hidden platform in WM. Our results indicate that repeated but not single oral TRP administration is involved in the enhanced memory functions in @entity35 .
