The renal sympathetic baroreflex in the XXXX . Arterial and cardiac baroreceptor influences, resetting, and effect of anesthesia.

@entity8 @entity1854 @entity95 @entity2647
Curves relating @entity8 and mean arterial pressure were derived in conscious @entity95 during ramp changes in mean arterial pressure, elicited by perivascular balloon inflation. The @entity8 -mean arterial pressure relationship consisted of a high-gain sigmoidal region about resting, where @entity8 rose or fell in response to moderate falls and rises of mean arterial pressure. With larger pressure rises, @entity8 first fell to a lower plateau and then reversed at even higher mean arterial pressure. When mean arterial pressure was lowered below resting, @entity8 rose to an upper plateau and then reversed abruptly toward resting at low mean arterial pressure. Both arterial and cardiac baroreceptors exerted substantial inhibitory influences on @entity8 at all pressure levels. These effects appeared additive over the central high gain region of the curve, but beyond this region there were non-additive interactions. The latter were affected considerably by alfathesin anesthesia. In other experiments, we studied the effects of sustained alterations in resting mean arterial pressure induced by infusing @entity1854 and @entity2647 , which produced rapid resetting of the renal baroreflex. The latter could be accounted for, in part, by resetting of the threshold of the arterial baroreceptors and in part by contributions from other afferents, probably the cardiac receptors. During resetting associated with @entity1854 -induced falls in resting blood pressure, high-gain reflex adjustments in @entity8 to moderate changes in mean arterial pressure were preserved, but during resetting associated with @entity2647 -induced rises in resting mean mean arterial pressure, the resting @entity8 lay on the lower curve plateau, resulting in reduction in the apparent gain of the reflex @entity8 response to moderate changes in mean arterial pressure.
