Mortality after radiotherapy for XXXX .

@entity1 @entity16071 @entity242 @entity1313 @entity5 @entity1778 @entity204 @entity11885
The mortality experience of 10,834 @entity1 treated with x-rays for @entity11885 between 1948 and 1960, 10,834 matched comparison subjects, and 5,392 siblings was evaluated over an average follow-up period of 26 years. Mortality was ascertained by linking unique personal identification numbers of study subjects with the national @entity204 registry. Radiotherapy in childhood was associated with an increased risk of @entity204 due to @entity5 of the head and neck (relative risk (RR) = 3) and @entity1778 ( @entity16071 .3). No other causes of @entity204 were significantly elevated after irradiation. The excess of @entity1313 (average intracranial dose = 150 rads) confirms that the central nervous system of the @entity1 is sensitive to the induction of @entity5 by radiation. The bone marrow dose averaged over the entire body was approximately 30 rad, and the estimated risk coefficient of 0.9 excess @entity1778 per million per year per rad is consistent with other studies of whole-body exposure. A significant @entity242 (RR = 9) was also observed. The pattern of @entity5 risk over time was bimodal; an early peak due to excess @entity1778 occurred within a few years of exposure, whereas excesses of solid @entity5 were most apparent after about 15 years. Despite the excess of @entity5 among exposed @entity1 , over 50% of the deaths in the entire study population were from external events, mainly accidents or events related to military service. An estimate of the total impact of @entity5 after childhood irradiation will require additional years of observation since the population irradiated is just now entering the age ranges normally associated with high @entity5 risk.
