Effects of thermal injury on skeletal metabolism in two strains of XXXX .

@entity1 @entity851 @entity19 @entity2331 @entity130
Long-term growth retardation occurs in @entity1 and @entity2331 occur among @entity1 and adults who have been burned or suffer other injuries that result in a systemic inflammatory response. The purpose of this study was to define some of the growth, and to determine cancellous and cortical bone changes that occur following @entity130 in several contrasting strains of @entity19 . Male C3H/HeN and Balb/c @entity19 were given about a 20% total @entity130 and 10 days later skeletal tissues were collected. The bone ash weights of the burned animals from both strains were less than their sham controls. In both strains, cancellous bone volumes were less in the burned animals than in their respective sham or baseline control groups. The loss of bone was particularly evident in the secondary spongiosa regions and also included a decrease in trabecular thickness and connectivity and an increase in trabecular separation. @entity851 was suppressed in the burn animals. In the burned animals, indices of cancellous bone formation were substantially reduced whereas those in cortical bone were essentially nonexistent. The numbers of osteoclasts were increased in cancellous bone, and endocortical eroded surface was increased in the burn animals. These data show that there are rapid and profound changes in skeletal growth and metabolism in an experimental model of @entity130 . In general, a greater relative response was observed in the Balb/c vs. the C3H/HeN strain. @entity130 resulted in a rapid and dramatic suppression of bone formation and endochondral growth with increased bone resorption in both cancellous and cortical bone.
