Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential XXXX .

@entity1 @entity8 @entity101 @entity2232 @entity540 @entity65
Previous evidence has demonstrated a relationship between growth factors and @entity65 . This study was aimed at evaluating levels of some endothelium-derived growth factors, and their relationship with microalbuminuria (MAU), in essential @entity101 . Ninety-nine mild-moderate essential @entity101 (EH) and 25 healthy controls were studied. All @entity1 underwent 24-h blood pressure monitoring, serum @entity2232 ( @entity2232 ), @entity540 ( @entity540 ) and platelet-derived growth factor (PDGF), and 24-h MAU assays. Later, EH were divided into two subsets consisting of microalbuminurics (MAU >11 microg/min) and nonmicroalbuminurics (MAU <11 microg/min). In microalbuminuric EH, circulating @entity2232 , @entity540 , and PDGF were significantly higher than in nonmicroalbuminurics (P < .0001, P < .0001, P < .005, respectively) or in controls. In the group of 99 EH, significant positive correlations of MAU with both @entity2232 and @entity540 (r = 0.35, P < .001, and r = 0.34, P < .001, respectively) were found. @entity2232 and @entity540 correlated significantly (r = 0.31, P < .002). Circulating @entity540 also correlated significantly with MAU in the microalbuminuric EH subset (r = 0.49, P < .01). Our results show that in microalbuminuric EH circulating levels of certain growth factors are increased. In @entity1 essential @entity101 these factors are linked with MAU, an early @entity8 marker.
