Complications associated with selective high-dose intraarterial @entity900 and concomitant radiation therapy for advanced XXXX .

@entity1 @entity135 @entity8962 @entity5 @entity900 @entity1410
PURPOSE: To describe the incidence and severity of complications associated with intraarterial @entity900 and concomitant radiation therapy for advanced @entity135 . MATERIALS AND METHODS: One hundred five @entity1 treated between June 1993 and March 1998 were studied. Forty-seven (44%) had T4 lesions and 40 (37%) had bulky (N2/3) nodal disease. Three hundred eighty-five procedures were performed. All @entity1 were treated with selective intraarterial @entity5 -directed @entity900 (150 mg/m(2) weekly x 4), simultaneous intravenous @entity8962 (9 g/m(2)) for systemic neutralization of @entity900 , and conventional external-beam radiation to the @entity5 and nodal disease (total dose of 66-74 Gy). RESULTS: One hundred five @entity1 were evaluated for complications. Twenty-two (5.7%) groin @entity1410 occurred, none of which needed therapy. Two asymptomatic common carotid artery dissections were reported. Two @entity1 experienced acute occlusion of the external iliac artery requiring a femorofemoral bypass. Overall, there were 41 grade III/IV chemotoxic events related to treatment. Chemotoxic events included 29 mucosal events, nine hematologic events, two otologic events, and one gastrointestinal event. No renal events occurred. There were three permanent and three transient neurologic events. CONCLUSION: Selective high-dose intraarterial @entity900 and concomitant radiation therapy for advanced @entity135 can be performed safely with a relatively low complication rate compared to standard intravenous chemotherapy treatment protocols.
