Effect of peroral esophageal myotomy for XXXX treatment: A Chinese study.

@entity1 @entity1318 @entity9285 @entity14303 @entity1017
AIM: To assess the safety and feasibility of peroral esophageal myotomy (POEM) in @entity1 with @entity1318 . METHODS: From January 2012 to March 2014, 50 @entity1 (28 @entity1 , 22 @entity1 ; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all @entity1 , both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure. RESULTS: POEM was successfully completed for all @entity1 . The mean procedure time was 55.4    17.3 min and the mean total length of myotomy of the circular esophagus was 10.5    2.6 cm. No specific complications occurred, with the exception of two @entity1 that developed asymptomatic @entity14303 and @entity9285 . Clinical improvement in symptoms was achieved in all @entity1 . Approximately 77.5% of @entity1 experienced @entity1017 6 mo after POEM, with an average of 4.78 kg (range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM (Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two @entity1 , but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm (P < 0.01). CONCLUSION: POEM can relieve @entity1318 symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.
