Tissue response to XXXX -based blend with phospholipid polymer for biodegradable cardiovascular stents.

@entity1 @entity15274 @entity95 @entity7049 @entity35 @entity715 @entity2945
A temporary cardiovascular stent device by bioabsorbable materials might reduce late stent @entity715 . A water-soluble amphiphilic phospholipid polymer bearing @entity2945 groups (PMB30W) was blended with a high-molecular-weight @entity7049 ( @entity15274 ) to reduce unfavorable tissue responses at the surface. The @entity15274 implants and the polymer blend ( @entity15274 /PMB30W) implants were inserted into subcutaneous tissues of @entity35 , the infrarenal aorta of @entity35 , and the internal carotid arteries of @entity95 . After 6 months subcutaneous implantation, the @entity15274 /PMB30W maintained high density of @entity2945 groups on the surface without a significant bioabsorption. After intravascular implantation, the cross-sectional areas of polymer tubing with diameters less than 1.6  mm were histomorphometrically measured. Compared to the @entity15274 tubing, the @entity15274 /PMB30W tubing significantly reduced the @entity715 formation during 30  d of implantation. @entity1 peripheral blood mononuclear cells were cultured on the @entity15274 and the @entity15274 /PMB30W to compare inflammatory reactions. Enzyme-linked immunosorbent assay quantified substantially decreased proinflammatory cytokines in the case of the @entity15274 /PMB30W. They were almost the same level as the negative controls. Thus, we conclude that the @entity2945 groups could reduce tissue responses significantly both in vivo and in vitro, and the @entity15274 /PMB30W is a promising material for preparing temporary cardiovascular stent devices.
