The significance of XXXX .

@entity1 @entity263 @entity5 @entity189 @entity1486
The diagnosis of @entity263 is most commonly made today by transrectal ultrasound guided needle biopsy. Often hypoechoic and peripheral zone lesions are the only areas sampled. Recently, we showed that this approach missed a quarter of the @entity5 that would be detected by a systematic biopsy technique. We term these missed @entity5 @entity189 . We reviewed 1,549 systematic sextant prostate needle biopsies, of which 417 @entity5 were detected and subdivided into @entity5 ( @entity5 detected on biopsy of a @entity5 ( @entity5 found only in normal [isoechoic] peripheral zone). We noted in @entity1 with only @entity5 that fewer biopsy cores per prostate revealed @entity5 (mean 1.6 versus 3.0, p < 0.0001) and that these @entity1 had lower serum @entity1486 levels (mean 14.4 versus 43.7, p < 0.001). The Gleason scores for the @entity5 were indistinguishable. The pathological staging of @entity5 was also similar. This study suggests that while @entity5 are generally smaller than @entity5 , they do not represent low grade clinically insignificant @entity189 . A systematic approach to performing prostate biopsy is recommended.
