Association of genetic variants of the XXXX H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication.

@entity1 @entity72472 @entity6 @entity28 @entity914 @entity72471 @entity1017 @entity112 @entity72473 @entity16237 @entity934
RATIONALE: Antipsychotic affinity for the @entity112 H1 receptor and the muscarinic M3 receptor have been associated with the side effects @entity1017 , and development of @entity6 , respectively. OBJECTIVES: We investigated polymorphisms of the @entity112 H1 (HRH1) and muscarinic @entity934 receptor M3 ( @entity16237 ) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c). METHODS: We included 430 Caucasian @entity1 with a non-affective @entity914 using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were @entity28 and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, @entity72471 and @entity72472 , and one SNP in the @entity16237 gene, @entity72473 , were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor. RESULTS: A significant association of interaction between haplotype @entity72471 - @entity72472 and BMI (p value 0.025) and @entity28 (p value 0.005) in @entity1 using high-H1 affinity antipsychotics versus @entity1 using low-H1 affinity antipsychotics was found. There was no association of @entity16237 gene variant @entity72473 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants. CONCLUSIONS: This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in @entity1 with a @entity914 using antipsychotics. In future, genotyping of HRH1 variants may help predicting @entity1017 in patients using antipsychotics.
