Enzymatically Modified Starch Ameliorates Postprandial Serum XXXX and Lipid Metabolome in Growing @entity1707 .

@entity1 @entity1707 @entity576 @entity4336 @entity1674 @entity11938 @entity19846 @entity3689 @entity413
UNASSIGNED: Developing host digestion-resistant starches to promote @entity1 health is of great research interest. @entity576 ( @entity576 ) are widely used in processed foods and although the modification of the starch molecule allows specific reduction in digestibility, the metabolic effects of @entity576 have been less well described. This short-term study evaluated the impact of enzymatically modified starch (EMS) on fasting and postprandial profiles of blood @entity413 , @entity11938 and lipids, and serum metabolome in growing @entity1707 . Eight jugular-vein catheterized @entity1707 (initial body weight, 37.4 kg; 4 months of age) were fed 2 diets containing 72% purified starch (EMS or waxy @entity4336 starch (control)) in a cross-over design for 7 days. On day 8, an 8-hour meal tolerance test (MTT) was performed with serial blood samplings. Besides biochemical analysis, serum was analysed for 201 metabolites through targeted mass spectrometry-based metabolomic approaches. @entity1707 fed the EMS diet showed increased (P<0.05) immediate serum @entity11938 and plasma @entity413 response compared to @entity1707 fed the control diet; however, area-under-the-curves for @entity11938 and @entity413 were not different among diets. Results from MTT indicated reduced postprandial serum @entity1674 with EMS versus control diet (P<0.05). Likewise, serum metabolome profiling identified characteristic changes in glycerophospholipid, lysophospholipids, @entity19846 and @entity3689 metabolome profiles with EMS diet compared to control diet. Results showed rapid adaptations of blood metabolites to dietary starch shifts within 7 days. In conclusion, EMS ingestion showed potential to attenuate postprandial raise in serum lipids and suggested constant alteration in the synthesis or breakdown of sphingolipids and phospholipids which might be a health benefit of EMS consumption. Because serum @entity11938 was not lowered, more research is warranted to reveal possible underlying mechanisms behind the observed changes in the profile of serum lipid metabolome in response to EMS consumption.
