Verbal memory impairment in new onset XXXX : Relationship with frontal and medial temporal morphology.

@entity1 @entity162 @entity73 @entity409 @entity1650 @entity4207
UNASSIGNED: Objectives. Verbal memory (VM) impairment is a trait feature of @entity162 ( @entity162 ) that is present at illness onset and associated with functional outcome. However, little is known about the morphological abnormalities underlying this deficit early in the disease course. This study examined the neurobiological correlates of @entity73 in euthymic newly diagnosed @entity1 , with attention to frontal and medial temporal (MT) structures known to contribute to VM. Methods. Euthymic @entity1 with @entity162 recently recovered from their first episode of @entity162 (n = 42) were compared with healthy subjects (n = 37) using measures of the California Verbal Learning Test (CVLT-II) associated with frontal and MT functioning. A subset of @entity1 had 3T MRI scan (n = 31 @entity1 group, n = 30 healthy subject group). Hippocampal and prefrontal volumes were analyzed using FreeSurfer 5.1 and correlated with their corresponding CVLT-II subscores. Results. @entity1 showed decreased performance in total learning as well as short and long delay verbal recall. Consistent with @entity409 , they also showed @entity1650 and @entity4207 . In the @entity1 group only, left hippocampal volumes were negatively correlated with these measures. Conclusions. These results suggest that anomalous MT functioning is involved with @entity73 early in the course of @entity162 .
