Effects of Olax gambecola @entity1042 extract on smooth muscle and XXXX blood pressure.

@entity4033 @entity101 @entity1042 @entity840 @entity95 @entity551 @entity2607 @entity3897 @entity1286 @entity35 @entity3352 @entity750 @entity460
A @entity1042 extract of the roots of Olax gambecola induced a biphasic contractile response consisting of a transitory initial rapid contraction (Phase I), followed by a slowly developing sustained increase in basal tone (Phase II) on @entity35 fundus, antrum, @entity840 taenia coli, @entity95 jejunum and aorta. The Phase I contraction was abolished by @entity3897 , attenuated significantly by @entity3352 and potentiated by @entity2607 while the Phase II response was unaffected. @entity4033 , @entity1286 , @entity750 ( @entity750 ) antagonists or desensitization of @entity750 receptors did not alter either the Phase I or the Phase II contractions. @entity460 channel blockers and procedures affecting @entity460 translocation abolished the Phase I contraction while only reducing the Phase II contractions. Transmural electrical stimulation produced contractions of the fundus which were attenuated by the extract. Single bolus injections of extract produced a rapid fall in blood pressure in both normotensive and spontaneously @entity101 @entity35 but intravenous infusion resulted in a sustained fall in blood pressure which was maintained throughout the infusion period. Chronic i.p. administration of extract to spontaneously @entity101 @entity35 reduced blood pressure markedly but did not alter the blood pressure of normotensive animals. The @entity551 response to single bolus injections was abolished by @entity3897 and potentiated by @entity2607 . The activity profile of the extract suggests the presence of at least two active principles in the crude extract of Olax gambecola used in this study.
