Effects of mono- and dual blockade of the renin-angiotensin system on markers of cardiovascular status in hypertensive XXXX with mild and moderate renal failure.

@entity1 @entity1289 @entity2922 @entity67 @entity7832
BACKGROUND/AIMS: Dual renin-angiotensin system (RAS) blockade has no more efficiency to decrease cardiovascular mortality than mono-blockade. Our goal was to explore differences between other cardiovascular markers in @entity1 with RAS blockade. METHODS: We analyzed two groups of @entity1 treated with a long-term @entity1289 inhibitor (MONO-group, n = 20) and an @entity1289 inhibitor and angiotensin II receptor blocker (DUAL-group, n = 15). Ambulatory blood pressure monitoring, echocardiography, arterial stiffness and levels of @entity2922 , endogenous @entity7832 (EO), pro-brain natriuretic peptide and more types of urinary albumin measurements were performed. RESULTS: In the DUAL-group, we found significantly better cardiac parameters, but the levels of EO and urinary albumins were similar in both groups. The level of EO correlates with nighttime mean arterial blood pressure (R = 0.556, p = 0.032) and arterial b-stiffness (R = 0.512, p = 0.042). Urinary immuno-unreactive albumin showed a relationship with @entity67 of the heart (R = -0.508, p = 0.045) diurnal index of diastolic blood pressure (R = -0.569, p = 0.021) in the MONO-group. CONCLUSION: Cardiac parameters were more prosperous in the DUAL-group, but the levels of EO did not differ between groups. The level of EO correlated with blood pressure and arterial stiffness markers in the MONO-group only. The urinary immuno-unreactive albumin may be a new marker of cardiovascular conditions.
