Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric @entity1 with XXXX .

@entity1 @entity73 @entity8568 @entity1019 @entity244 @entity6349
UNASSIGNED: Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between @entity8568 ( @entity8568 ), intrahemispheric association pathways, and network function. Methods. Each @entity1019 ( @entity1019 ) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of @entity6349 cortex in the expected anatomic locations of Broca's (BA) and @entity244 ( @entity244 ) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 @entity8568 @entity1 and 16 age/gender-matched controls were included. All normative controls had an identifiable left @entity1019 . 6/7 @entity8568 @entity1 with @entity6349 cortex within BA and/or @entity244 had no left @entity1019 ; @entity8568 @entity1 without involvement of these regions had a lower frequency of absence of the left @entity1019 (p < 0.006). All @entity1 without a left @entity1019 had some degree of @entity73 . @entity8568 @entity1 without a left @entity1019 had a significantly greater frequency of @entity73 compared to those @entity8568 @entity1 with a left @entity1019 (p < 0.003). Conclusion. In @entity1 with @entity8568 (1) the presence of @entity6349 cortex within @entity244 and/or BA is associated with absence of the left @entity1019 and (2) absence of the left @entity1019 is associated with @entity73 .
