Pathogens of skin and skin-structure infections in the UK and their susceptibility to antibiotics, including XXXX .

@entity1 @entity801 @entity796 @entity5176 @entity1066 @entity40629 @entity794 @entity2886
OBJECTIVES: Bacterial skin and skin-structure infections (SSSIs) are frequent settings for antibiotic use. We surveyed their UK aetiology and pathogen susceptibility, including susceptibility to @entity40629 . METHODS: Consecutive SSSI isolates were collected at 35 UK hospitals, to a maximum of 60/site, together with 15 'supplementary' @entity794 /site. Isolates were re-identified and BSAC susceptibility testing was performed, with parallel CLSI agar testing for @entity40629 . RESULTS: Isolates (n=1908) were collected from 1756 hospitalized @entity1 , predominantly with surgical and traumatic infections, abscesses and infected @entity1066 and largely from general medicine and general surgery @entity1 . They included 1271 @entity794 (201 @entity794 ), 162 b-haemolytic streptococci, 269 Enterobacteriaceae, 138 @entity796 and 37 enterococci. Most (944/1756) @entity1 had monomicrobial MSSA infections. Rates of resistance to @entity5176 , @entity801 and @entity2886 were <20% in Enterobacteriaceae and <10% in @entity796 . @entity794 rates varied greatly among hospitals and were 2.5-fold higher in general medicine than in general surgery @entity1 . At breakpoint, @entity40629 inhibited: (i) all MSSA and 97.6% of @entity794 , with MICs of 2 mg/L for the few resistant @entity794 ; (ii) all b-haemolytic streptococci; and (iii) 83% of Enterobacteriaceae. High-level @entity40629 resistance in Enterobacteriaceae involved ESBLs or AmpC enzymes. @entity40629 MICs by CLSI methodology generally equalled those by BSAC or were 2-fold higher, but this differential was 4-16-fold for @entity796 . CONCLUSIONS: Irrespective of @entity1 group, SSSIs were dominated by @entity794 . Most pathogens were susceptible, but 15.8% of @entity794 were @entity794 , with locally higher prevalence.
