XXXX after en bloc salvage surgery for @entity135 .

@entity1 @entity135 @entity5 @entity260 @entity213
OBJECTIVE: To analyze the frequency of and risk factors for @entity260 after en bloc salvage surgery for @entity135 . DESIGN: Retrospective cohort study. SETTING: @entity1 were evaluated from February 7, 1990, to November 17, 1999, in a tertiary @entity5 center hospital. @entity1 : Consecutive sample of 124 @entity1 from the hospital database. Only @entity1 with recurrent @entity213 undergoing en bloc salvage resection were eligible for the study. MAIN OUTCOME MEASURES: We analyzed the frequency of and risk factors for complications after salvage surgery. RESULTS: The @entity5 location was the lip in 6 @entity1 , oral cavity in 55, oropharynx in 31, larynx in 24, and hypopharynx in 8. Previous treatment was surgery alone in 20 @entity1 , radiotherapy alone in 68, surgery and radiotherapy in 21, and radiotherapy and chemotherapy in 14. An additional @entity1 received chemotherapy alone before salvage surgery. The clinical stage of the recurrent @entity5 was I or II in 23 @entity1 and III or IV in 101 @entity1 . @entity260 occurred in 66 @entity1 (53.2%). Fifty-three @entity1 (42.7%) had minor complications, and 23 @entity1 (18.5%) had major ones. There were 4 postoperative deaths (3.2%). The major factor associated with the overall occurrence of @entity260 was the clinical stage of the recurrent @entity5 (P =.02). The occurrence of minor complications correlated with the previously treated site, with complications occurring more often in @entity1 undergoing locoregional vs local treatment (P =.04). Major complications were associated with the time between initial treatment and salvage surgery (P =.05). CONCLUSIONS: Salvage surgery can be performed with acceptable rates of @entity260 . The clinical stage of the recurrent @entity5 and the previous site treated were the 2 major factors associated with the occurrence of @entity260 .
