Studies on serum lipoproteins of XXXX developing spontaneous @entity407 .

@entity407 @entity1 @entity1674 @entity412 @entity5522 @entity35 @entity165
The lipid composition of the serum lipoproteins of @entity35 with varying degrees of @entity407 was investigated. The concentrations of all the lipoproteins were increased with increasing @entity407 . The elevation was found to be more pronounced for very low density VLDL) and low density (LDL) than for high density lipoproteins (HDL). A linear relationship exists between @entity412 and @entity165 contents of VLDL fractions independent of the VLDL level. Eighty to ninety per cent of serum @entity1674 are located in the VLDL fraction. Linear relationships were found between the levels of serum @entity1674 or VLDL @entity1674 and the levels of LDL and HDL @entity165 , respectively. Furthermore, linear relationships exist between total @entity165 content in serum and @entity165 concentration in VLDL, LDL and HDL, respectively. Thus, lipoprotein levels may be estimated by measuring serum @entity165 or @entity412 concentrations. Disk electrophoresis and ultracentrifugation revealed that the LDL fraction (d. 1.006 - 1.063) could be divided into two fractions, which both increase with age. The spontaneous @entity5522 of the old @entity35 make these animals suitable as a model for evaluation of drugs against @entity1 @entity5522 .
