Anti-annexins autoantibodies: their role as biomarkers of XXXX .

@entity1 @entity51349 @entity10784 @entity2597 @entity4404 @entity1252 @entity49 @entity1701 @entity3830 @entity460 @entity244 @entity393 @entity792 @entity309 @entity785
Annexins are a group of 12 highly conserved proteins which exert several regulatory functions on cell biology. There are involved in numerous cell processes including vesicle trafficking, @entity460 signaling, cell growth, division, and apoptosis. Autoantibodies directed toward annexin I, II, V and XI have been reported, but their role and their clinical correlates are controversial. Annexin I exerts an anti-inflammatory effect by suppressing the generation of inflammatory mediators and anti-annexin I antibodies were detected in @entity1 affected with @entity309 , systemic ( @entity1252 ) and @entity3830 . @entity10784 and V have a high affinity for phospholipids playing a pivotal role in the regulation of coagulation cascade. Anti- @entity10784 and anti- @entity4404 antibodies were found in @entity1 with arterial or @entity49 , especially in those with @entity792 ( @entity792 ) such as @entity1252 , @entity1701 ( @entity1701 ) or @entity785 . Anti- @entity4404 antibodies were also found in @entity1 with @entity393 with or without @entity1701 . @entity51349 is involved in several biological pathways, particularly apoptosis and cell proliferation. Anti- @entity51349 antibodies have been found in @entity1 with @entity1252 , @entity2597 , @entity309 , @entity244 and @entity1701 . The metanalysis of studies published up to now showed that the Odds Ratio for having an @entity792 in anti- @entity51349 positive @entity1 was 5.08 (95% CI 2.06-12.58).
