XXXX After Robotic-Assisted Radical Prostatectomy Is Not Associated with Perioperative Outcome and Histopathological Findings.

@entity1 @entity263 @entity5 @entity190 @entity86
INTRODUCTION: Recently a retrospective study has been published describing a significant correlation of immediate @entity86 (IPLC) and a favorable pathological Gleason score (pGS) in @entity1 undergoing robotic-assisted radical prostatectomy (RARP). The aim of the present study was to prospectively validate these results on an external dataset. MATERIALS AND METHODS: In total, 346 @entity1 undergoing RARP as first-line therapy for @entity263 were included. Clinical and histopathological parameters, criteria of IPLC, and pGS were recorded prospectively. Potential association between IPLC and pGS was evaluated by univariate and multivariate analyses. RESULTS: IPLC was found in 77.2% (n   =   267) of all @entity1 with a median leukocyte blood count (LBC) of 12.5   *   10(9)/L (interquartile range, 10.2-15   *   10(9)/L). Of these, in 255 @entity1 IPLC was found within the range of 10-20   *   10(9)/L, whereas an IPLC of >20   *   10(9)/L was found in only 12 @entity1 . Of the @entity1 , 49.1%, 40.5%, and 10.4% presented with a pGS6, pGS7, and pGS8-10 @entity5 , respectively. There was neither a univariate nor a multivariate correlation between IPLC and pGS. Furthermore, no significant correlation could be detected between IPLC and other clinical, intraoperative, or histopathological criteria. In 175 (66%) @entity1 with IPLC normal LBC levels were measured on postoperative Day 4. CONCLUSIONS: IPLC was not associated with more favorable @entity5 biology (lower pGS, better @entity5 stage) and not influenced by @entity1 conditions (age, body mass index, American Society of Anesthesiologists score, smoking) or intraoperative parameters ( @entity190 , operating time, surgeon). In addition, there was no significant correlation with serious complications (Clavien-Dindo Grade 3a/b) within a period of 90 days.
