The Epidemiology of Nonsurgical XXXX in Denmark: A Nationwide Case Finding Study.

@entity1 @entity231 @entity174 @entity177 @entity261 @entity395 @entity461
UNASSIGNED: @entity261 ( @entity261 ) is a @entity395 most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low @entity461 levels. Knowledge about this group of @entity1 , including their mortality and morbidity, is very sparse. The aim was to identify all @entity1 diagnosed with nonsurgical @entity261 in Denmark and assess their mortality and risk of complications. Through registers and review of individual @entity1 hospital charts we identified all @entity1 diagnosed with nonsurgical @entity261 in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age- and gender-matched population-based controls. We identified a total of 180 @entity1 with nonsurgical @entity261 among whom 123 (68%) were alive at the date of follow-up (prevalence of 2.3/100,000 inhabitants). Compared with controls, mortality was not increased, but @entity1 had a significantly increased risk of @entity177 (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), @entity231 (HR 4.21), and @entity174 at the upper extremities (HR 1.93). In contrast @entity1 had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical @entity261 is a rare disease associated with a number of complications that should be considered when taking care of these @entity1 .    2015 American Society for Bone and Mineral Research.
