Overnight use of continuous low-level heatwrap therapy for relief of XXXX .

@entity1 @entity1643 @entity5018 @entity158 @entity121
OBJECTIVE: To evaluate of the efficacy and safety of 8 hours of continuous, low-level heatwrap therapy administered during sleep. DESIGN: Prospective, randomized, parallel, single-blind (investigator), placebo-controlled, multicenter clinical trial. SETTING: Two community-based research facilities. @entity1 : Seventy-six @entity1 , aged 18 to 55 years, with acute, nonspecific @entity1643 . INTERVENTIONS: Subjects were stratified by baseline @entity158 intensity and gender and randomized to one of the following treatments: evaluation of efficacy (heatwrap, n=33; oral placebo, n=34) or blinding (unheated wrap, n=5; oral @entity5018 , n=4). All treatments were administered for 3 consecutive nights with 2 days of follow-up. MAIN OUTCOME MEASURES: Primary: morning @entity158 relief (hour 0) on days 2 through 4 (0-5-point verbal response scale). Secondary: mean @entity158 relief score (days 2-4, hours 0-8), mean extended @entity158 relief score (day 4, hour 0; day 5, hour 0), @entity121 , lateral trunk flexibility, and disability (Roland-Morris Disability Questionnaire). RESULTS: Heatwrap therapy was significantly better than placebo at hour 0 on days 2 through 4 for mean @entity158 relief (P=.00005); at hours 0 through 8 on days 2 through 4 for @entity158 relief (P<.001); at hour 0 on day 4 and at hour 0 on day 5 for mean @entity158 relief (P<.001); on day 4 in reduction of morning @entity121 (P<.001); for increased lateral trunk flexibility on day 4 (P<.002); and for @entity1643 on day 4 (P=.005). Adverse events were mild and infrequent. CONCLUSIONS: Overnight use of heatwrap therapy provided effective @entity158 relief throughout the next day, reduced @entity121 and disability, and improved trunk flexibility. Positive effects were sustained more than 48 hours after treatments were completed.
