Cerebral changes and XXXX after an ischemic heart disease: a multimodal MRI study.

@entity1 @entity1187 @entity73 @entity409
UNASSIGNED: Three to 6  months after an @entity1187 ( @entity1187 ), @entity73 is observed in more than 30  % of the @entity1 , mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of @entity409 . Thirty-three @entity1 were recruited 4      1  months after a first @entity1187 . Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4      1  months after @entity1187 ) and 6  months later (ie 10      1  months after @entity1187 ). Using both time-points, we identified 3 groups of @entity1 according to normative data based on age, gender and education level: 15 'cognitively normal' @entity1 without impairment at each follow-up, 10 'transient @entity73 ' @entity1 with an impairment only at baseline and 8 'impairing' @entity1 with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between @entity73 and cognitively normal @entity1 . At the functional level, compared to the 'cognitively normal' group, the 'transient @entity73 ' @entity1 presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the 'impairing' @entity1 presented only a non-significant decrease of functional connectivity. @entity409 in @entity1187 @entity1 is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient @entity73 @entity1 . Further studies with larger sample size are needed to confirm these results and to determine if these @entity1 could be at higher risk for developing permanent @entity73 .
