Small intestinal @entity413 absorption and duodenal motility in XXXX .

@entity1 @entity6 @entity10546 @entity46850 @entity4148 @entity413
OBJECTIVE: Small intestinal @entity413 absorption is increased in animal models of @entity6 , but little data are available in @entity1 . Small intestinal motility is reported to be frequently abnormal in @entity1 with @entity6 and could potentially affect @entity413 absorption. Our aim was to evaluate small intestinal @entity413 absorption and duodenal motor responses to intraduodenal nutrients, in @entity1 with type 1 @entity6 and controls. METHODS: Eight type 1 @entity1 (two with @entity4148 ) and nine controls were studied during euglycemia. A manometric catheter was positioned across the pylorus, and nutrient infused intraduodenally (90 kcal over 30 min), followed by a bolus of @entity10546 ( @entity46850 ). Blood was sampled to measure @entity413 and @entity46850 concentrations. RESULTS: During nutrient infusion, the number of duodenal waves did not differ between @entity1 and controls. After the infusion, @entity1 with @entity6 had more propagated duodenal wave sequences (p < 0.05). The area under the plasma @entity46850 curve did not differ between the groups but correlated with both the blood @entity413 concentration at the time of @entity46850 administration (r = 0.64, p < 0.005) and the number of duodenal waves (r = 0.52, p < 0.05) and antegrade propagated duodenal sequences (r = 0.51, p < 0.05) preceding the @entity46850 bolus. CONCLUSIONS: During euglycemia, duodenal motor responses to small intestinal nutrient are comparable in @entity1 with relatively uncomplicated type 1 @entity6 and healthy subjects, but duodenal motility after nutrient infusion is increased in @entity1 . Small intestinal @entity413 absorption is similar in @entity1 and controls, but may be dependent on the blood @entity413 concentration and duodenal motor activity.
