[Acne, @entity3428 and oral XXXX resistance. 23 cases. Therapeutic implications].

@entity1 @entity3428 @entity10211 @entity43
BACKGROUND: We earlier demonstrated that oral @entity10211 can be associated with @entity3428 in @entity1 with acne. The aim of this study was to evaluate the causal relationships of the different etiologies in case of unsuccessful treatment. @entity1 AND METHODS: The study group included 120 @entity1 with late-onset acne resistant to different treatment and signs of @entity3428 . A complete hormone work-up was obtained in all @entity1 . There was a group of 23 @entity1 who failed to respond to @entity10211 and 97 @entity1 in the control group. Unsuccessful treatment was defined as persistance of grade 2 lesions after a mean cumulative dose of 166 mg/kg @entity10211 . RESULTS: In the non-responders to @entity10211 , @entity3428 was observed in 22 out of 23 cases: pituitary (n = 2), adrenal (n = 5), ovarian (n = 13), peripheral (n = 2). In the control group, @entity3428 was found in 89 out of 97 @entity1 : pituitary (n = 6), adrenal (n = 45), ovarian (n = 33), peripheral (n = 5). The distribution of two etiologies, ovary and adrenal, demonstrated a significant difference between @entity10211 non-responders and controls, the former having a higher frequency of @entity43 . DISCUSSION: These findings confirm that untreated @entity43 , is a source of unsuccessful treatment with oral @entity10211 .
