Histological analysis of myleran induced XXXX of longitudinal deficiency in @entity35 .

@entity11898 @entity3145 @entity509 @entity35 @entity56515
In this study, @entity11898 was used as a model of @entity11898 and the pathogenesis of the @entity56515 of @entity11898 was investigated. @entity11898 was induced in @entity35 fetuses by a single oral administration of myleran to pregnant @entity35 on day 10 of pregnancy. The dose of myleran administered was 40 mg/kg of body weight. In order to observe the process of formation of the foot plates and digital rays of @entity11898 , histological examination was done. The period of development studied was from day 12 to 16 of pregnancy. A series of fetuses was surgically removed from their mothers at 12 hours' interval. Histological examinations of the hind limbbuds and foot plates were performed quantitatively. The formation of hind limbbuds was detected on day 12 in myleran treated group as in control group. The formation of digital rays in the myleran treated group was initially observed on day 14.5, 12 hours later than control. The size of hind limbbuds and the density of mesenchymal cells in hind limbbuds treated by myleran was smaller than control and the @entity509 of the limbbuds was maximum on day 14. The shape of foot plates treated by myleran was asymmetrical compared with the symmetrical limbbuds in controls. Concerning @entity3145 in limbbuds, dead cells of ectoderm were distributed on the top of the limbbuds on day 12 and they disappeared 24 hours later. On the other hand, dead cells of mesenchyme were scattered in hind limbbuds on day 12.(ABSTRACT TRUNCATED AT 250 WORDS)
