Integrated PET/MR mammography for quantitative analysis and correlation to prognostic factors of XXXX .

@entity1 @entity419 @entity0 @entity5 @entity513 @entity3
BACKGROUND: We investigated the relationship between @entity419 PET parameters and apparent diffusion coefficient (ADC) values obtained by diffusion weighted MRI (DWI) in @entity1 with @entity513 ( @entity513 ). In addition, the prognostic utility of PET/MR mammography parameters was compared with that of known histologic prognostic factors. METHODS: Forty-six @entity1 aged 50.7    10.5 years underwent a preoperative PET/MR mammography assessment using an integrated PET/MR scanner. T1w, T2w, DWI [b value = 50, 400, and 800 s/mm2], dynamic contrast enhancement sequences, and @entity419 PET imaging were performed. IDCs were assessed using SUVmax values and intratumoral heterogeneities (IH) from the @entity419 PET images and mean (ADCmean) and minimum ADC (ADCmin) values were measured using the DWI images. Relationships between the PET parameters and ADC values were evaluated. Furthermore, SUVmax and ADC values were compared with histologic factors, @entity5 size, nodal status, @entity3 , Ki-67 expression and @entity0 ( @entity0 ). RESULTS: In total 46 IDCs (2.1-7.5 cm in size) were analyzed. SUVmax (p = 0.012) and elevated IH (p = 0.041) were negatively correlated with ADCmin, then @entity0 (p = 0.013) and high Ki-67 expression (p = 0.002) were associated with higher SUVmax. @entity513 with @entity3 had low ADCmin values (p = 0.045). CONCLUSION: @entity419 PET metabolic parameters and ADCmin were negatively correlated. PET parameters and ADC values might reflect the expression of biological features of @entity5 and @entity5 invasiveness, respectively. Integrated PET/MR mammography seemed like to have potential of a one-stop method for evaluating and predicting the prognosis of @entity513 .
