The XXXX protein is a key regulator of nuclear architecture in differentiating @entity521 cells.

@entity1 @entity28552 @entity12922 @entity521 @entity2057 @entity369 @entity14827
The cell nucleus contains two closely related structures, Cajal bodies (CBs) and gems. CBs are the first site of accumulation of newly assembled splicing snRNPs (small nuclear ribonucleoproteins) following their import into the nucleus, before they form their steady-state localization in nuclear splicing speckles. Gems are the nuclear site of accumulation of survival motor neurons (SMNs), an insufficiency of which leads to the @entity14827 , @entity2057 ( @entity2057 ). @entity28552 is required in the cytoplasm for the addition of core, Sm, proteins to new snRNPs and is believed to accompany snRNPs to the CB. In most cell lines, gems are indistinguishable from CBs, although the structures are often separate in vivo. The relationship between CBs and gems is not fully understood, but there is evidence that symmetrical dimethylation of @entity369 residues in the CB protein coilin brings them together in HeLa cells. During neuronal differentiation of the @entity1 @entity521 cell line SH-SY5Y, CBs and gems increase their colocalization, mimicking changes seen during foetal development. This does not result from alterations in the methylation of coilin, but from increased levels of @entity28552 . Expression of exogenous @entity28552 results in an increased efficiency of @entity12922 transport to nuclear speckles. This suggests different mechanisms are present in different cell types and in vivo that may be significant for the tissue-specific pathology of @entity2057 .
