Prognostic significance of Traf2- and Nck- interacting kinase ( @entity73302 ) in XXXX .

@entity1 @entity5 @entity73302 @entity9134 @entity14
BACKGROUND: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of @entity5 has been realized. This study aimed to identify a novel biomarker for @entity14 ( @entity14 ). METHODS: The expression profiles of @entity5 cells in 152 @entity1 with stage I-III @entity14 were examined using microarray analysis. High expression in @entity14 cells, especially in @entity1 with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected @entity9134 - and Nck-interacting kinase ( @entity73302 ), which was known to be associated with progression in @entity14 through Wnt signaling pathways. We analyzed the protein expression of @entity73302 using immunohistochemistry (IHC) and investigated the relationship between protein expression and @entity1 characteristics in 220 stage I-III @entity14 @entity1 . RESULTS: Relapse-free survival was significantly worse in the @entity73302 high expression group than in the @entity73302 low expression group in stage II (p   =   0.028) and stage III (p   =   0.006) @entity1 . In multivariate analysis, high @entity73302 expression was identified as a significant independent risk factor of distant recurrence in stage III @entity1 . CONCLUSION: This study is the first to demonstrate the prognostic significance of intratumoral @entity73302 protein expression in clinical tissue samples of @entity14 , in that high expression of @entity73302 protein in primary @entity5 was associated with distant recurrence in stage II and III @entity14 @entity1 . This @entity73302 IHC study might contribute to practical decision-making in the treatment of these @entity1 .
