Alteration of G2 cell cycle regulators occurs during XXXX of the endometrium.

@entity1204 @entity10610 @entity14050 @entity8189 @entity876 @entity10609 @entity1478 @entity1869 @entity105 @entity9516
OBJECTIVES: In this study, we examined the alteration of the G2 pathway in @entity1869 ( @entity1869 ) and @entity1204 (EC), and analyzed the relationship between the G2 pathway status and the @entity876 pathway status. METHODS: A total of 103 cases (proliferative phase of the endometrium: 20, @entity1869 : 22, and endometrioid-type EC: 61 (I: 39, II: 5, III: 15, recurrence: 2)) were included in this study. We examined the @entity14050 , @entity9516 , @entity10609 , @entity10610 , and @entity8189 protein expression by immunohistochemistry. In 55 cases ( @entity1869 : 15; EC: 40), we analyzed @entity9516 mutations by RT-PCR-SSCP. RESULTS: There were no @entity9516 mutations in @entity1478 . Elevated or reduced expression rates of @entity14050 , @entity9516 , @entity10609 , @entity10610 and @entity8189 were 4.5% (1/22), 0%, 0%, 0% and 4.5% (1/22) in @entity1869 and 3.3% (2/61), 4.9% (3/61), 13.1% (8/61), 9.8% (6/61) and 9.8% (6/61) in EC. Alteration of the G2 pathway was higher in EC (32.8%; 20/61) than in @entity1869 (9.1%; 2/22; p = 0.047). The G2 pathway was significantly higher in the altered @entity876 pathway group (48.4%; 15/31) than in the normal @entity876 pathway group (16.7%; 5/30) in EC (p = 0.0134). The altered @entity876 pathway tended to be related with the @entity10610 / @entity8189 status (p = 0.0529). CONCLUSIONS: Alteration of the G2 pathway is thought to occur during @entity105 of the endometrium.
