Growth index is independent of microvessel density in XXXX .

@entity7 @entity5 @entity1149 @entity2279 @entity876 @entity3 @entity105
Induction of angiogenesis is essential for @entity105 and facilitates the processes of @entity5 development and @entity3 . @entity7 ( @entity7 ) is an important angiogenic regulator under physiologic and pathologic conditions. To elucidate the role of angiogenesis in malignant growth, we evaluated angiogenesis and @entity7 expression in a panel of 68 @entity1149 ( @entity1149 ) and examined their relation with the kinetic parameters, ploidy, and @entity876 protein status, which have been analyzed previously. Angiogenesis was estimated as microvascular density (MVD) of the @entity5 area by @entity2279 immunodetection. Expression of @entity7 was also immunohistochemically evaluated. All possible associations were assessed through a series of statistical methods. The mean MVD value was 39 microvessels/mm(2), and high @entity7 immunoreactivity was observed in all specimens, with a mean percentage of positive cells of 73%. The relation between MVD and @entity7 expression was not statistically significant (P = 0.065). No association was observed between MVD or @entity7 levels with the proliferation index, apoptotic index, @entity5 ploidy status, @entity876 expression, and overall survival. We conclude that in a subset of @entity1149 , angiogenesis may be associated with @entity7 , but other factors also participate in this process. Angiogenesis and growth (proliferation and apoptosis) are independent and probably differentially operated procedures, with only growth partially controlled by @entity876 protein expression.
