The expression of MACC1 and its role in the proliferation and apoptosis of salivary XXXX .

@entity1 @entity5 @entity2347 @entity900 @entity982 @entity3 @entity694
BACKGROUND: The objective of this study was to investigate the relationship between @entity3 -associated in @entity694 and @entity1 clinical characteristics. We also examined the role of @entity3 -associated in @entity694 in the proliferation and apoptosis in @entity2347 . MATERIAL AND METHODS: @entity3 -associated in @entity694 expression was analysed in 65 @entity982 -embedded tissue specimens of salivary @entity2347 and 25 adjacent non-cancerous tissues by immunohistochemistry (IHC). We used RNA interference technology to silence @entity3 -associated in @entity694 expression in ACCM cells. Cell Counting Kit-8 tests, transwell experiments and flow cytometry were used to test the proliferation, @entity900 resistance, migration, invasion and apoptosis of ACCM cells. RESULTS: @entity3 -associated in @entity694 nuclear and cytoplasmic expression in salivary @entity2347 tissue was higher than in the adjacent normal salivary tissue. The expression level was closely associated with @entity5 histological grading, perineural invasion and surrounding @entity5 invasion. The downregulation of @entity3 -associated in @entity694 expression inhibited proliferation and induced apoptosis in ACCM cells. The knock-down of @entity3 -associated in @entity694 expression had no effect on migration, invasion and chemoresistance. CONCLUSIONS: @entity3 -associated in @entity694 may have an important role in @entity5 development in @entity2347 . @entity3 -associated in @entity694 is a potential biomarker for @entity2347 .
