Effects of nidus microarchitecture on XXXX hemodynamics.

@entity1 @entity7026 @entity2758
UNASSIGNED: Intranidal vessel geometry and organization underlying flow within @entity7026 ( @entity2758 ) is poorly understood. We examine the relationship between intranidal vessel characteristics and @entity2758 flow. Records of @entity1 with @entity2758 evaluated at our institution between 2007 and 2013 were retrospectively reviewed. @entity1 were included if surgical specimens were available and flows were obtained before treatment using quantitative magnetic resonance angiography. Intranidal vessels were identified and the diameter and cross-sectional area of each vessel were measured from digitized images of specimen slides. The relationship between vessel diameter, vessel cross-sectional area, @entity2758 volume, and @entity2758 flow was assessed. Twenty-nine @entity1 were included. Mean total number of vessels per specimen was 133. Mean total @entity2758 flow was 340  276mL/min. Mean vessel diameter ranged from 0.18-2.37mm and mean vessel cross-sectional area ranged from 0.09-9.46mm(2). Linear regression analysis showed that total flow is significantly associated with larger @entity2758 volume (R(2)=0.28, P=0.007), but not with number of vessels per section of the specimen (P=0.20) or mean vessel diameter (P=0.92). Exponential regression analysis demonstrated that @entity2758 flow is significantly correlated to the sum of the cross-sectional vessel areas within each specimen (R(2)=0.16, P=0.05). Total @entity2758 flow is significantly related to sum of the cross-sectional areas of all vessels within each nidus, rather than to total number of vessels or mean nidal vessel diameter. This finding suggests that the sum of the cross-sectional areas of intranidal vessels likely determines the resistance to flow within a @entity7026 .
