Freezing of gait in XXXX is associated with altered functional brain connectivity.

@entity1 @entity2167 @entity191 @entity6556 @entity221
BACKGROUND: @entity1 with @entity191 ( @entity191 ) may develop several gait disturbances during the @entity221 and Freezing of gait ( @entity6556 ) is one of them. Several neuroimaging studies have been conducted to identify the neural correlates of @entity6556 but results have not been uniform. Resting state functional MRI (rs-fMRI) is relatively less explored in @entity191 @entity1 with @entity6556 . This study aims to compare the whole brain resting state connectivity of @entity191 @entity1 with and without @entity6556 using rs-fMRI. METHODS: rs-fMRI was obtained for 28 @entity191 @entity1 (15 with and 13 @entity1 without @entity6556 ) who were matched for various demographic and clinical characteristics. Seed to voxel analysis was performed at whole brain level and compared between the two groups. RESULTS: When compared to @entity1 without @entity6556 , the @entity1 with @entity6556 had reduced functional connectivity across multiple seeds. Major finding was reduced inter-hemispheric connectivity of left parietal opercular cortex with multiple regions of the brain primarily involving the primary @entity2167 , which also negatively correlated with the FOGQ scores. CONCLUSION: Our findings suggest that alterations in the resting state functional connectivity of the opercular parietal cortex may be one of the substrates of @entity6556 . Reduced interhemispheric connectivity probably is the reason for impairment of control and coordination in bilateral leg movements while walking.
