Corpus callosum section and other disconnection procedures for medically intractable XXXX .

@entity1 @entity410 @entity75 @entity149 @entity51 @entity302
Corpus callosum section for carefully selected @entity1 with uncontrolled @entity302 has become more acceptable as operative complications have decreased. From consideration of anatomical pathways utilized in the spread of @entity410 discharges, section of the corpus callosum is expected to decrease, but not abolish, bilaterally synchronous EEG abnormalities arising from most cerebral locations, perhaps excluding the temporal lobe. Clinical experience confirms this expectation. Persistence of some bilateral synchrony, presumably through subcortical relays, does not usually diminish the effectiveness of corpus callosum section on clinically generalized @entity410 that are eliminated or markedly decreased in 85% of @entity1 after total corpus callosum section. Generalized @entity410 types that respond include tonic, atonic, @entity410 . @entity1 who continue to have generalized @entity410 usually have low IQ and perhaps extensive bilateral cerebral involvement increases the extent to which subcortical structures participate in generalization. Complex partial @entity410 may cease, usually in @entity1 with well-circumscribed, often extratemporal @entity410 foci. Focal @entity410 intensify in 25% of @entity1 ; a predictable consequence of sectioning interhemispheric inhibitory connections. Permanent disconnection syndromes, which are only rarely symptomatic, include sensory disconnection after posterior section, and @entity75 after total section. A small percentage of @entity1 develop impairments in language, motor, or memory functions. @entity51 are predicted by pre-existing unilateral mild or moderate @entity149 . Partial section of the corpus callosum produces control of generalized @entity410 half as frequently as complete section. Neurologic sequelae of partial section occur nearly as frequently but are less severe.
