Dental manifestations of XXXX and abnormalities of collagen I metabolism.

@entity1 @entity8804 @entity18456 @entity3466 @entity4500 @entity6926
The in vitro protein-chemical features and the molecular background of @entity6926 ( @entity6926 ), a heritable disorder of collagen I metabolism, have been elucidated in recent years. The aim of our study was to find the prevalence of @entity8804 ( @entity8804 ) and other @entity4500 in 88 @entity1 with @entity6926 , to compare clinical with radiologic abnormalities, and to correlate these clinical/radiologic findings with the results of gel electrophoresis and molecular studies of collagen I. Twenty-eight percent of @entity6926 @entity1 had @entity8804 . Most @entity1 with @entity8804 had radiologic abnormalities, but some @entity1 had radiologic signs compatible with @entity8804 , but no clinical signs of @entity8804 . @entity6926 @entity1 with @entity8804 were more severely affected by @entity6926 than those without @entity8804 . In @entity18456 and IV, in contrast, there was no difference in overall severity between @entity1 with and without @entity8804 . @entity8804 was not associated with any particular molecular aberration in any @entity6926 type. If defining @entity8804 from the presence of both clinical and radiologic signs, collagen I produced by cultured fibroblasts was qualitatively abnormal from all @entity6926 @entity1 with @entity8804 . Some @entity6926 @entity1 had dental abnormalities not resembling @entity8804 . A qualitative collagen abnormality could not be found in any of these @entity1 . Denticles, i.e., calcifications within the @entity3466 , were found more frequently in @entity6926 @entity1 than in control subjects.
