@entity40759 interacts with plasma @entity10194 concentrations to influence insulin resistance in individuals with the XXXX .

@entity2175 @entity40759 @entity844 @entity462 @entity209 @entity10194 @entity141 @entity72642 @entity1718 @entity413
BACKGROUND: @entity40759 protein (intracellular @entity141 -dependent @entity462 protease) may play a role in @entity413 metabolism, pancreatic b cell function, and regulation of thermogenesis. Several @entity40759 polymorphic sites have been studied for their potential use as risk markers for @entity2175 ( @entity209 ). @entity1718 are key metabolic regulators that may interact with genetic factors and influence @entity413 metabolism. OBJECTIVE: The objective was to examine whether the genetic variability at the @entity40759 gene locus is associated with the degree of insulin resistance and plasma @entity844 concentrations in subjects with @entity209 . DESIGN: The insulin sensitivity index, @entity413 effectiveness, insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)], insulin secretion (disposition index, acute insulin response, and HOMA of b cell function), plasma @entity844 composition, and 5 @entity40759 single nucleotide polymorphisms (SNPs) were determined in a cross-sectional analysis of 452 subjects with @entity209 participating in the LIPGENE dietary intervention cohort. RESULTS: The @entity72642 SNP interacted with plasma total @entity10194 ( @entity10194 ) concentrations, which were significantly associated with insulin sensitivity (P < 0.031 for fasting insulin, P < 0.028 for HOMA-IR, and P < 0.012 for @entity413 effectiveness). The G/G genotype was associated with lower fasting insulin concentrations, lower HOMA-IR, and higher @entity413 effectiveness in subjects with low @entity10194 concentrations (below the median) than in subjects with the minor A allele (G/A and A/A). In contrast, subjects with the G/G allele with the highest @entity10194 concentrations (above the median) had higher fasting insulin and HOMA-IR values and lower @entity413 effectiveness than did subjects with the A allele. CONCLUSION: The @entity72642 polymorphism at the @entity40759 gene locus may influence insulin sensitivity by interacting with the plasma @entity844 composition in subjects with @entity209 . This trial was registered at clinicaltrials.gov as NCT00429195.
