The action of XXXX on isolated coronary arteries of different species.

@entity1 @entity1707 @entity235 @entity3897 @entity3451 @entity734 @entity934
The action of @entity934 ( @entity3451 ) on extramural coronary arteries (CA) of @entity235 , @entity1707 , and @entity1 was tested in vitro. @entity3451 dilated precontracted @entity235 CA in @entity734 on the state of endothelium. This dilation was mediated through muscarinic receptors since @entity3897 inhibited it effectively. Preparations without active precontraction were not influenced at all or slightly dilated. Both @entity1 and porcine CA were exclusively contracted by @entity3451 independently of the presence or absence of precontraction. The @entity3451 contraction in porcine CA was found to be endothelium-independent, but also inhibited by @entity3897 as well as the @entity3451 contraction in @entity1 CA. Adrenoceptor blockers did not influence @entity3451 reactivity. High concentrations of @entity3451 (greater than 10(-5) mol/l) decreased the further responsiveness of the vessels to the mediator (tested in @entity235 and @entity1707 only). Spontaneous mechanical activity was registered only in @entity1 CA. Different @entity3451 reactivity in @entity235 compared with @entity1707 and @entity1 is interpreted as species-dependent. It must be taken into account when @entity1 coronary physiology is modeled in animals.
