Surgical acquired XXXX : myth or reality?

@entity1 @entity63 @entity254 @entity1963 @entity11451 @entity35 @entity21 @entity1142
PURPOSE: A number of @entity1 operated on for @entity1963 continue to have @entity1142 and abdominal distension for years after surgery. Some authors have proposed that @entity63 during surgery may induce @entity1963 . The aim of the present study was to study the effects of @entity63 on the enteric nervous system of sigmoid colon in an animal model. METHODS: A surgical model of @entity63 was created. 34 adult @entity35 underwent a laparotomy where the marginal arterioles of the sigmoid colon were ligated. After that, a section in the middle segment of the sigmoid colon was performed followed by an @entity254 . The presence of @entity63 was assessed by measurement of visible light spectroscopy tissue oximetry and histological examination. Colonic function was assessed by evaluation of stool weight. @entity35 were killed at 1, 8 and 12 weeks after the operation. 12 @entity35 were sham-operated. Enteric nervous system was evaluated by means of immunohistochemistry with @entity11451 p75. Quantitative analysis of the number of @entity21 and ganglion cells in the myenteric plexus was performed. RESULTS: The surgical model of @entity63 significantly decreased tissue oxygenation (pre-surgical = 54.69    7.32 %; post-surgical = 27.37    9.2 %; p < 0.001). There was no disturbance in body-weight gaining in experimental groups and daily stool output did not vary after surgery (pre-surgical = 4.24    0.94 g; post-surgical = 3.82    1 g; p = 0.09). All experimental groups showed persistent @entity21 . However, there was a significant decrease in the number of @entity21 in all the experimental groups compared to control (1w: 45.91    7.66; 8w: 44.17    10.56; 12w: 36.17    15.06 vs control: 56.88    8.66; p < 0.01). The number of total ganglion cells was significantly reduced only in the experimental group killed at week 12 compared to control (1w: 539    167.58; 8w: 488.58    154.41; 12w: 343.94    161.91 vs control: 513.96    126.97; p < 0.01). The rate of ganglion cells per @entity21 was significantly higher in the groups killed at week 1 and 8 versus control group (1w: 11.63    2.53; 8w: 11.11    2.56; 12w: 9.34    1.16 vs control: 9.02    1.81; p < 0.05). CONCLUSION: Long-term follow-up after surgically induced @entity63 in the @entity35 showed a decreased number of ganglion cells and @entity21 . Nevertheless, it did not produce @entity1963 .
