Postpartum resolution of glomerular changes in @entity4 - @entity644 - XXXX @entity1468 .

@entity1 @entity644 @entity8 @entity101 @entity4 @entity1468 @entity6064
Complete resolution of glomerular changes in @entity6064 of pregnancy has been reported to occur as early as 4 weeks postpartum, whereas their persistence for as long as 2 years in some instances has been noted. However, the mechanism of resolution remains obscure. Percutaneous renal biopsy was performed in 22 @entity1 between 10 and 14 days after delivery. These @entity1 fulfilled the criteria for @entity6064 of pregnancy ( @entity4 - @entity644 - @entity101 @entity1468 ). Biopsy specimens were examined, using light, immunofluorescence and electron microscopy. Semithin sections were studied in view of greater reliability and better relation with further electron microscopic studies. A diffuse increase in mesangial cellularity and matrix was seen in all glomeruli with varying intensity, compatible with mesangium activity, more than endothelial proliferation. So-called capillary occlusions by endothelial swelling were not observed in the biopsies taken 10 days after delivery, but expulsed mesangial cytoplasm could be observed incidentally in the capillary lumen. This phenomenon may explain the wrong interpretation of paraffin sections studied by light microscopy. The presence of immunoglobulins in the glomeruli, seen by immunofluorescence, seems to be nonspecific trapping. In view of experimental studies of mesangium function in macromolecular uptake and processing, it is possible that resolution of the characteristic @entity8 in @entity6064 is promoted by mesangium activity.
