Effect of intracoronary thrombolytic therapy on exercise-induced ischemia after XXXX .

@entity1 @entity37706 @entity3885 @entity1188 @entity741 @entity583
Intracoronary streptokinase (SK) therapy increases vessel patency rate after @entity583 ( @entity583 ) and thus may lead to a greater exercise-induced @entity741 . This hypothesis was tested in 39 @entity1 enrolled in an angiographically randomized trial of intracoronary SK (19 treated with SK and 20 control subjects); all @entity1 underwent thallium-201 scintigraphy at rest before acute angiography, as well as at rest and during stress 5 to 6 weeks after @entity583 . The @entity1 were classified into 2 groups based on the presence (n = 13) or absence (n = 26) of @entity37706 at the end of the acute angiography. Semiquantitative score of myocardial thallium uptake was expressed as percent of maximal defect score. Thallium defect score at rest between admission and 5 to 6 weeks' study decreased from 10 +/- 16% units in the control group and from 23 +/- 14% units in the SK group (p = 0.01). This decrease was related to opening of the @entity1188 (opening 23 +/- 16% vs occlusion 5 +/- 10%). The change in exercise-induced defect score was significantly (p = 0.01) larger in @entity1 in the SK group (11 +/- 6% units) than in those in the control group (5 +/- 7% units). The perfusion defect during exercise was larger (p = 0.006) in @entity1 with @entity3885 (10 +/- 6% units) than in @entity1 with @entity3885 (3 +/- 7%). This difference was independent of the number of diseased coronary vessels.(ABSTRACT TRUNCATED AT 250 WORDS)
