Treatment of XXXX with endobronchial application of synthetic hydrogel (CoSeal).

@entity1143 @entity1 @entity16058 @entity39 @entity2415 @entity519 @entity370
Abstract: Background: @entity1143 with persistent air leak is a common problem causing significant morbidity, prolonged hospital stay and increased health care costs. When conventional therapy fails, an alternative to prolonged chest tube drainage or surgery is needed. New bronchoscopic techniques have been developed to close the air leak by reducing the flow of air through the leak. The objective of this study was to analyze our experience with bronchoscopic application of a synthetic hydrogel for the treatment of such fistulas. Methods:We conducted a retrospective study of @entity1 with @entity1143 with persistent air leaks, treated with synthetic hydrogel application via flexible bronchoscopy. @entity1 characteristics, underlying disease and outcome of endoscopic treatment were analyzed. Results:Between January 2009 and December 2013, 22 @entity1 (14 @entity1 , 8 @entity1 ; mean age    SD, 62    10 years) were treated with one to three applications of a synthetic hydrogel per @entity1 . The primary etiology of persistent air leak was @entity39 pneumonia (n=8), post thoracic surgery (n=6), @entity2415 (n=5), @entity16058 (n=2) and @entity370 (n=1). Nineteen @entity1 (86%) had a complete resolution of the air leak leading to successful removal of chest tube 4.3    0.9 days post last bronchoscopic application. The procedure was very well tolerated, with two @entity1 coughing up the hydrogel and one having @entity519 requiring bronchoscopic suctioning. Conclusion:Bronchoscopic administration of a synthetic hydrogel is an effective, nonsurgical, minimally invasive intervention for @entity1 with persistent pulmonary air leaks secondary to @entity1143 . Background: @entity1143 with persistent air leak is a common problem causing significant morbidity, prolonged hospital stay and increased health care costs. When conventional therapy fails, an alternative to prolonged chest tube drainage or surgery is needed. New bronchoscopic techniques have been developed to close the air leak by reducing the flow of air through the leak. The objective of this study was to analyze our experience with bronchoscopic application of a synthetic hydrogel for the treatment of such fistulas. Methods: We conducted a retrospective study of @entity1 with @entity1143 with persistent air leaks, treated with synthetic hydrogel application via flexible bronchoscopy. @entity1 characteristics, underlying disease and outcome of endoscopic treatment were analyzed. Results: Between January 2009 and December 2013, 22 @entity1 (14 @entity1 , 8 @entity1 ; mean age    SD, 62    10 years) were treated with one to three applications of a synthetic hydrogel per @entity1 . The primary etiology of persistent air leak was @entity39 pneumonia (n=8), post thoracic surgery (n=6), @entity2415 (n=5), @entity16058 (n=2) and @entity370 (n=1). Nineteen @entity1 (86%) had a complete resolution of the air leak leading to successful removal of chest tube 4.3    0.9 days post last bronchoscopic application. The procedure was very well tolerated, with two @entity1 coughing up the hydrogel and one having @entity519 requiring bronchoscopic suctioning. Conclusion: Bronchoscopic administration of a synthetic hydrogel is an effective, nonsurgical, minimally invasive intervention for @entity1 with persistent pulmonary air leaks secondary to @entity1143 .
