Technique and outcome of autotransplanting thyroid tissue after XXXX .

@entity1 @entity1136 @entity6145 @entity4510
BACKGROUND/OBJECTIVE: Limited animal and @entity1 studies have shown function, albeit inadequate, of implanted thyroid tissue in muscles. This work aimed to ascertain results in a larger number of @entity1 , finding practical method for implantation, studying the effect of changing weight of implant and effect of passage of time on its function. METHODS: Forty @entity1 had @entity4510 . A piece of the excised gland was finely minced, mixed with saline as emulsion, and injected in thigh muscles. Twelve @entity1 had 5-g implants, while 28 @entity1 had 10-g implants. Four parameters were studied at 2 months, 6 months, and 12 months: @entity1136 isotope uptake by the implant; thyroid stimulating hormone (TSH); free T3 (FT3); and free T4 (FT4). RESULTS: All autotransplanted thyroid tissue survived and functioned. After 12 months, mean values (   standard deviation) of isotope uptake, TSH, FT3, and FT4 of the 5-g implants were 0.44      0.16%, 27.74      30.4  UI/mL, 3.07      1.10 pg/mL, and 1.01      0.3  ng/dL, repectively. Those for the 10  g implants were 0.71      0.20%, 22.78      19.7  UI/mL, 3.92      1.2  pg/mL, and 1.05      0.3  ng/dL, repectively. Ten-gram implants showed significantly higher isotope uptake than 5-g. TSH, FT3, and FT4 significantly improved over the period of 1 year. CONCLUSION: Injection of thyroid tissue suspension is a simple method for thyroid autotransplantation. TSH was elevated in the majority to maintain normal or near normal thyroid hormones. Ten-gram implants showed higher isotope uptake than 5-g, although this difference was not reflected by @entity6145 profile. The implant seemed to function better with the passage of time from 2 months to 12 months.
