Adhesion molecules in XXXX .

@entity1 @entity32 @entity66 @entity4725 @entity31 @entity29 @entity4105 @entity2071 @entity30
The ability of leucocytes to adhere to endothelium is essential for leucocyte migration into inflammatory sites. Some of these adhesion molecules are released from the cell surface and can be detected in serum. The soluble adhesion molecules @entity2071 ( @entity2071 ), @entity4105 , and @entity4725 ( @entity4725 ) were studied in the serum of @entity1 with @entity30 , @entity31 , and healthy controls. A second blood sample was taken from @entity1 with @entity66 after one month of treatment and a third two months after remission was achieved. Tissue expression of the same adhesion molecules was studied by immunohistology. Circulating @entity4725 concentrations were significantly higher in @entity1 with active @entity31 (n = 11, median = 165 U/ml) compared with @entity1 with inactive @entity31 (n = 10, median = 117 U/ml, p < 0.005), active @entity30 (n = 12, median = 124 U/ml, p < 0.02), and controls (n = 90, median = 50 U/ml, p < 0.0001). Within each disease group there were no significant differences in @entity4105 or @entity2071 concentrations between the active and inactive states, however, @entity1 with active @entity30 had significantly higher @entity2071 concentrations (n = 12, median = 273 ng/ml) than controls (n = 28, median = 168, p < 0.003). @entity4725 concentrations fell significantly from pretreatment values to remission in active @entity31 (p < 0.01). In @entity30 there was a significant fall in @entity2071 both during treatment (p < 0.01) and two months after remission (p < 0.02). Vascular expression of @entity2071 occurred more often and was more intense in inflamed tissue sections from @entity1 with @entity31 and @entity30 than from controls. Vascular labelling with antibody to @entity4105 also occurred more often in @entity1 with active @entity29 . In conclusion, increased circulating concentrations of selected adhesion molecules are associated with @entity29 . There is also evidence of local upregulation, particularly of @entity2071 . Differential expression of adhesion molecules in tissue may play a part in the initiation of leucocyte migration and local @entity32 ; the function of circulating adhesion molecules is unknown, but may play a physiological part in blocking adhesion.
