[Malnutrition increases hippocampal neurogenesis in the immature XXXX after @entity159 ].

@entity1 @entity1603 @entity410 @entity12988 @entity4176 @entity22163 @entity302 @entity3147 @entity40 @entity35 @entity159
OBJECTIVE: Neurogenesis in the dentate gyrus of hippocampus persists in brain of the immature and adult @entity1 including @entity1 and it can be regulated by physiological and pathological events including nutritional status and @entity410 . The present study was designed to investigate the potential effects of @entity3147 followed by @entity302 on hippocampal neurogenesis in the immature @entity35 . METHODS: @entity35 pups were divided into 4 groups: malnourished (M), nourished (N), @entity410 ( @entity410 ) and @entity410 ( @entity410 ). The @entity35 pups of group M and group @entity410 were maintained on a starvation regimen from postnatal day 2 (P2) to @entity12988 . The @entity159 of the @entity35 pups in group @entity410 and group @entity410 was elicited by unilateral microinfusion of @entity4176 (KA) into the amygdula at @entity22163 . @entity35 pups of the 4 groups were given @entity1603 ( @entity1603 ) intraperitoneally twice daily for 2 days beginning at P17. At P19, the @entity35 pups were killed and the brains were processed for @entity1603 mitotic labeling combined with double-label immunohistochemistry using early neuron- or glia-specific markers TuJ1 (beta III tubulin) or @entity40 ( @entity40 ). RESULTS: There were no significant differences in the latent time of @entity410 between group M and group N [(12.4 +/- 2.6) min vs. (12.1 +/- 2.9) min, P < 0.05]. Histological assessment did not reveal any evidence of hippocampal cell loss after @entity159 in either group. @entity1603 -labeled cells were significantly higher in the @entity35 of group @entity410 (374 +/- 18) than group M (303 +/- 20), group @entity410 (312 +/- 24) than group N (269 +/- 18), respectively (P < 0.01). There was also significant difference between group M and group N, group @entity410 and group @entity410 , respectively (P < 0.01). No significant difference was seen between the @entity35 of group @entity410 and group M (P > 0.05). Approximately 60% of @entity1603 -labeled cells coexpressed TuJ1, and 5% approximately 10% of those co-expressed @entity40 . CONCLUSION: Early @entity3147 do not alter KA @entity410 susceptibility and the behavioral manifestations of @entity410 at @entity22163 . Although @entity3147 and @entity159 can increase the proliferation of newly developed cells in the immature @entity35 respectively, @entity3147 followed by @entity159 further increases this proliferation. Furthermore, most of newly developed cells differentiate into early neurons.
