XXXX during liver transplantation as determined by @entity15901 .

@entity1 @entity8 @entity177 @entity810 @entity1011 @entity15901 @entity413 @entity454
@entity810 ( @entity810 ) has significant prognostic implications for long-term outcomes in @entity1 undergoing liver transplantation. In several retrospective studies, perioperative variables have been associated with @entity810 . These variables have been mainly associated with changes in @entity1011 concentrations over several days or months post-transplantation. To better define @entity810 , new markers have become available that help to identify @entity1 at risk for @entity8 within hours of a triggering insult. We prospectively enrolled liver transplant @entity1 at our institutions to evaluate @entity15901 ( @entity15901 ), a marker of early @entity8 , as a surrogate for @entity810 in @entity1 undergoing liver transplantation. Blood was prospectively collected at predetermined time points from 59 @entity1 at 2 institutions. The electronic anesthesia records and the hospital computer data system were reviewed for perioperative variables. Data collection included @entity1 demographics, intraoperative variables such as fluid management, transfusion requirements, hemodynamics, and urine output. Subsequently, @entity1 were grouped according to the presence of risk for developing @entity810 as defined by the RIFLE (risk, @entity177 , loss, and @entity454 ) criteria. The difference between the @entity15901 concentration 2 hours after reperfusion and the baseline @entity15901 concentration was predictive of @entity810 in all @entity1 , including @entity1 with preexisting @entity8 . In @entity1 with @entity1011 concentrations less than 1.5 mg/dL, a single @entity15901 determination 2 hours after reperfusion of the liver was associated with the development of @entity810 . Total occlusion of the inferior vena cava was associated with @entity810 . In conclusion, @entity15901 concentrations obtained during surgery were highly associated with postoperative @entity810 in @entity1 undergoing liver transplantation. These findings will allow the design of larger interventional studies. Our findings regarding the impact of surgical techniques and @entity413 require validation in larger studies.
