@entity5 regression and positional changes in XXXX during radical radiotherapy.

@entity1 @entity5 @entity1149 @entity2 @entity891
INTRODUCTION: We have used respiratory-correlated cone beam computed tomography (rcCBCT) imaging to study the volumetric and positional changes that occur throughout the course of radical radiotherapy in @entity1149 ( @entity1149 ). METHODS: @entity5 volumes and centers of mass were recorded and analyzed on weekly serial rcCBCT images of @entity1149 @entity1 treated with radical radiotherapy to a dose >= 45 Gy with concurrent chemotherapy. RESULTS: Sixty @entity1 with locally advanced @entity1149 were included; in 31 @entity1 , the @entity5 was peripheral and thus suitable for contouring. There was a mean percent decrease of 40.2% by fraction 15 and 51.1% by treatment completion. Among all 60 @entity1 , 19 @entity1 (32%) had more than 30% regression by fraction 15 and 25 @entity1 (81%) by treatment completion. Statistically significant @entity5 migration in at least one direction between the first and the last 2 weeks was demonstrated in 14 of 27 @entity1 . Clinically relevant changes ( @entity891 and effusions) were noted in 11 of 29 visually assessed @entity1 . CONCLUSIONS: Current rcCBCT image quality allows assessment of @entity5 located more peripherally. Significant @entity5 regression was documented in the majority of @entity1 . In view of these observations, the suitability of adaptive radiotherapy in @entity2 treatment should be further investigated.
