Overweight as predictor of long-term mortality among healthy, middle-aged XXXX : a prospective cohort study.

@entity1 @entity410 @entity65 @entity165
OBJECTIVES: Large epidemiological studies of non-smokers have demonstrated an association between overweight during midlife and increased mortality. However, little is known about whether this association may be explained by physical @entity410 . Thus, we aimed to examine this association in a long-term follow-up, with adjustment for @entity410 . METHODS: We prospectively studied mortality in relation to overweight in 2014 healthy Norwegian @entity1 40-59 years of age at enrollment in 1972-1975, and recorded cardiovascular and non- @entity65 during 25-27 years follow-up. Physical @entity410 was measured in a maximal exercise tolerance bicycle test. RESULTS: At baseline 717 @entity1 had overweight (body mass index 25.0-29.9) and 1221 had normal weight (body mass index<25.0). During follow-up 746 @entity1 died, 377 from cardiovascular causes. Among non-smokers with overweight/normal weight, @entity65 rates were 19.4%/11.3%, and @entity65 rates were 13.2%/14.4%. Overweight was related to @entity65 , even after adjustment for age, physical @entity410 , blood pressure and @entity165 level (RR: 1.52, p=0.010), but not to non- @entity65 (RR: 0.84, p=0.32). Among smokers overweight was not associated with cardiovascular or non- @entity65 . The difference in @entity65 between non-smokers with overweight and normal weight first appeared after 15 years of follow-up. CONCLUSION: Overweight appears to be an independent long-term predictor of @entity65 in middle-aged healthy non-smoking @entity1 , even after adjustment for physical @entity410 .
