Effects of exogenous @entity5445 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral @entity413 in older individuals with normal @entity413 tolerance or @entity164 2 XXXX .

@entity1 @entity5735 @entity6 @entity6029 @entity5736 @entity4202 @entity164 @entity551 @entity413 @entity5445 @entity2449
AIMS/HYPOTHESIS: A postprandial fall in BP occurs frequently in older individuals and in @entity1 with @entity164 2 @entity6 . The magnitude of this decrease in BP is related to the rate of gastric emptying (GE). Intravenous administration of @entity5445 ( @entity5445 ) attenuates the @entity551 response to intraduodenal @entity413 in healthy older individuals. We sought to determine the effects of exogenous @entity5445 on BP, GE, @entity6029 ( @entity6029 ) flow and glycaemic response to oral ingestion of @entity413 in healthy older individuals and @entity1 with @entity164 2 @entity6 . METHODS: Fourteen older volunteers (six @entity1 , eight @entity1 ; age 72.1        1.1  years) and ten @entity1 with @entity164 2 @entity6 (six @entity1 , four @entity1 ; age 68.7        3.4  years; HbA1c 6.6        0.2% [48.5        2.0  mmol/mol]; nine with blood @entity413 managed with @entity2449 , two with a @entity5736 and one with a @entity5735 inhibitor) received an i.v. infusion of @entity5445 (0.9  pmol  kg(-1)  min(-1)) or saline (154  mmol/l @entity4202 ) for 150  min (t   =   -30  min to t   =   120  min) in randomised order. At t   =   0  min, volunteers consumed a radiolabelled 75  g @entity413 drink. BP was assessed with an automated device, GE by scintigraphy and @entity6029 flow by ultrasonography. Blood @entity413 and serum insulin were measured. RESULTS: @entity5445 attenuated the fall in diastolic BP after the @entity413 drink in older individuals (p   <   0.05) and attenuated the fall in systolic and diastolic BP in @entity1 with @entity164 2 @entity6 (p   <   0.05). GE was faster in @entity1 with @entity164 2 @entity6 than in healthy individuals (p   <   0.05). In both groups, individuals had slower GE (p   <   0.001), decreased @entity6029 flow (p   <   0.05) and a lower degree of glycaemia (p   <   0.001) when receiving @entity5445 . CONCLUSIONS/INTERPRETATION: Intravenous @entity5445 attenuates the @entity551 response to orally administered @entity413 and decreases @entity6029 flow, probably by slowing GE. @entity5445 and 'short-acting' @entity5445 agonists may be useful in the management of postprandial @entity551 .
