T5 spinal cord transection increases susceptibility to reperfusion-induced @entity1165 by enhancing sympathetic activity in conscious XXXX .

@entity1164 @entity1619 @entity1165 @entity63 @entity1563 @entity591 @entity2224 @entity35 @entity451 @entity204
We recently documented that @entity451 ( @entity1619 (5) spinal cord transection) alters cardiac electrophysiology and increases the susceptibility to @entity1165 induced by programmed electrical stimulation. However, @entity1563 is the leading cause of @entity204 in industrially developed countries and will be the major cause of @entity204 in the world by the year 2020. The majority of these deaths result from @entity591 that culminate in @entity2224 . beta-Adrenergic receptor antagonists have been shown to reduce the incidence of @entity1164 . Therefore, we tested the hypothesis that chronic @entity1619 (5) spinal cord transection increases the susceptibility to clinically relevant @entity63 -reperfusion-induced sustained @entity1165 due to enhanced sympathetic activity. Intact and chronic (4 wk after transection) @entity1619 (5) spinal cord-transected ( @entity1619 (5)X) male @entity35 were instrumented to record arterial pressure, body temperature, and ECG. In addition, a snare was placed around the left main coronary artery. The susceptibility to sustained @entity1165 produced by 2.5 min of occlusion and reperfusion of the left main coronary artery was determined in conscious @entity35 by pulling on the snare. Reperfusion culminated in sustained @entity1165 in 100% of @entity1619 (5)X @entity35 (susceptible @entity1619 (5)X, 10 of 10) and 0% of intact @entity35 [susceptible intact, 0 of 10 (P < 0.05, @entity1619 (5)X vs. intact)]. Beta-adrenergic receptor blockade prevented reperfusion-induced sustained @entity1165 in @entity1619 (5)X @entity35 [susceptible @entity1619 (5)X 0 of 8, 0% (P < 0.05)]. Thus @entity451 increases the susceptibility to reperfusion-induced sustained @entity1165 due to enhanced sympathetic activity.
