Effect modification of XXXX on associations between endogenous @entity134 sex hormones and @entity729 in @entity1 at midlife.

@entity1 @entity251 @entity28 @entity53 @entity730 @entity134 @entity342 @entity729 @entity443
OBJECTIVE: The aim of this study was to examine whether @entity28 modifies the effects of endogenous @entity134 sex hormones on @entity729 in @entity1 at midlife. METHODS: Associations between @entity53 , @entity251 , @entity443 , and free @entity342 index and the presence and extent of coronary and aortic @entity730 were evaluated in 187 @entity28 (body mass index, >= 30 kg/m) and 281 nonobese (body mass index, <30 kg/m) @entity1 from the Study of @entity1 's Health Across the Nation. Logistic and linear regressions were used as appropriate. RESULTS: Prevalence rates of coronary and aortic @entity730 were significantly higher among @entity28 compared with nonobese @entity1 (P < 0.001, for both). In multivariable analyses, @entity134 sex hormones were not associated with the presence of coronary @entity730 . However, for the extent of coronary @entity730 , significant interactions were found between @entity28 and both @entity443 (P < 0.0001) and free @entity342 index (P = 0.008). In nonobese @entity1 , higher @entity443 (P = 0.0006) and lower free @entity342 index (P = 0.01) were associated with a greater extent of coronary @entity730 , whereas lower @entity443 was associated with greater extent of coronary @entity730 in @entity28 @entity1 (P = 0.05). For aortic @entity730 outcomes, higher @entity443 was associated with the presence of aortic @entity730 among nonobese @entity1 (odds ratio, 1.64; 95% CI, 1.16-2.32, for each 1-SD greater @entity443 ). CONCLUSIONS: Associations between endogenous @entity134 sex hormones and @entity729 vary by @entity28 status among perimenopausal @entity1 . Further research is needed to better understand the possible mechanisms of these associations.
