The efficacy of oral isotretinoin versus cyproterone compound in female @entity1 with acne and the triad of cutaneous XXXX : A randomized clinical trial.

@entity1 @entity5477 @entity19857 @entity3428 @entity74 @entity751 @entity3427
BACKGROUND: SAHA ( @entity19857 , @entity5477 , Hirsutism and Androgenetic Alopecia) syndrome is a @entity74 , with variant response to treatment. Triad of cutaneous @entity3428 included nodulocystic or severe acne, female pattern hair loss and @entity3427 . AIM: The aim of this study is to compare the effectiveness of isotretinoin and cyproterone compound in the treatment of @entity5477 , in @entity1 with @entity751 or triad of cutaneous @entity3428 . MATERIALS AND METHODS: 30 female @entity1 with @entity751 were divided randomly into two groups. Group A was treated with cyproterone compound from day 5 of menstrual cycle onwards for 3 weeks and a week without it and group B received isotretinoin, with a dose of 0.75 mg/kg per day from the beginning of menses onwards for 4 months. The results were evaluated by a blind dermatologist using @entity5477 Severity Index (ASI) score at baseline and monthly for 4 months. RESULTS: Despite a continuous reduction in ASI score in both the groups, according to both physician (P = 0.63) and @entity1 (P = 0.25) assessment, cyproterone compound was not statistically more effective than conventional treatment of @entity5477 at the end of the study. Side-effects were reported in @entity1 in both groups, generally being mild and tolerable except in two subjects. CONCLUSION: This study indicates that cyproterone compound is not superior to isotretinoin in the treatment of @entity5477 in @entity1 with @entity751 or triad of cutaneous @entity3428 . Indeed, other studies are needed to evaluate the effect of cyproterone compound (regardless of androgen level) and isotretinoin in subjects with only @entity5477 .
