Internally vs. externally triggered movements in @entity1 with XXXX .

@entity1 @entity308 @entity73 @entity191 @entity51 @entity1155
BACKGROUND: Psychomotor retardation is a prominent clinical feature of @entity308 . While several studies investigated these deficits, differences between internally and externally triggered response selection and initiation are less well understood. In the current study, we delineate internally vs. externally driven response selection and initiation in @entity308 and their relation to @entity1155 . METHODS: 20 inpatients diagnosed with a (unipolar) @entity308 and 20 closely matched healthy controls performed a computerized motor paradigm assessing differences between internally and externally cued movements. Psychomotor performance and basic memory functions were assessed using a neuropsychological test-battery. To examine within group homogeneity a multivariate clustering approach was applied. RESULTS: @entity1 featured a global slowing of internally and externally cued response selection compared to controls, as well as impairments in @entity1155 . Yet, basic motor speed was preserved. Furthermore, @entity1 were more severely impaired when movements involved internal response selection. The data-driven clustering revealed two @entity1 subgroups, which both showed @entity1155 , while only one featured slowing of response selection. INTERPRETATION: The results suggest a differential rather than a global @entity1155 slowing in @entity308 with specific @entity73 as cognitive aspects of @entity1155 functioning. As found for @entity308 , in @entity191 internally cued movements are more severely affected than externally cued reactions. Both may therefore be caused by dopaminergic deregulation due to @entity51 . Finally, multivariate clustering of behavioral data may be a promising future approach to identify subtypes of @entity73 in different @entity1 populations.
