Effect of @entity5101 on accelerated rejection in XXXX heart transplantation.

@entity137 @entity548 @entity39 @entity5101 @entity5252 @entity35
The effect of @entity5101 ( @entity5252 ) on accelerated rejection was evaluated using a @entity35 heart transplantation model. Lewis @entity35 (LEW, RT1l) served as the organ recipient and Brown @entity35 (BN, RT1n) as the donor. In the accelerated rejection model, the LEW recipient was sensitized with BN skin and BN heart was transplanted 7 days later; the heart graft was rejected within 2 days (n = 7). Histologically, the graft showed @entity39 and @entity548 throughout the myocardium. @entity5252 (2.5 mg/kg/day) was administered to the recipient under the following three protocols: group 1: during the sensitization period (7 days); group 2: from 3 days after the sensitization to 2 days after grafting (7 days), and group 3: immediately after heart transplantation. The mean graft survival period in groups 1, 2, and 3 was 4.3 +/- 0.8 days (n = 7, p < 0.01 vs untreated host), 11.7 +/- 2.1 days (n = 7, p < 0.001, vs. untreated host), and 2.0 +/- 0 days (n = 6), respectively. The rejected grafts in groups 1 and 3 histologically showed @entity39 and @entity548 . By contrast, in group 2, the major histological change was interstitial lymphocyte infiltration and there were few findings such as @entity39 or @entity548 . In the complement-dependent @entity137 test, serum obtained at the second posttransplant day from the recipients treated in group 1 showed a high @entity137 level, although the @entity137 level of serum obtained from the recipients treated in group 2 was consistently low.(ABSTRACT TRUNCATED AT 250 WORDS)
