Large maculopapular @entity75 are associated with favorable outcome in childhood-onset XXXX .

@entity1 @entity20145 @entity66 @entity5310 @entity75 @entity20131 @entity17586 @entity272
BACKGROUND: Mastocytosis, characterized by pathologic accumulation of mast cells, can manifest itself in adulthood or childhood. Pediatric @entity1 usually have @entity20145 ( @entity20145 ) with mast cell infiltrates limited to the skin and spontaneous improvement of @entity272 after several years. However, there are some @entity1 with persistent disease resembling adulthood-onset @entity5310 . OBJECTIVE: The current classification of @entity20145 differentiates between 3 subforms. In clinical practice we noticed that different variants of these subforms might exist, particularly in @entity1 with childhood-onset @entity5310 . Therefore, in the present study, we aimed to investigate whether specific @entity75 in @entity1 with childhood-onset @entity5310 are associated with other disease parameters. METHODS: We analyzed 144 @entity1 with a disease onset of less than age 17 years using a systematic dermatologic approach. RESULTS: One hundred twenty-two @entity1 presented with @entity17586 ( @entity17586 ), 12 @entity1 presented with diffuse @entity20145 , and 10 @entity1 presented with solitary @entity20131 . @entity1 with @entity17586 showed particularly heterogeneous @entity75 and were therefore grouped into 3 variants presenting either with small lesions ( @entity17586 -small, @entity272 <1 cm in diameter; n  = 19), large lesions ( @entity17586 -large, @entity272 >= 1 cm in diameter; n  = 89), or @entity75 ( @entity17586 -other, n  = 14). @entity1 with @entity17586 -large lesions, compared with those with @entity17586 -small lesions, were characterized by significantly lower tryptase levels, @entity66 onset. In addition, more @entity1 with @entity17586 -large lesions exhibited spontaneous regression of @entity75 . CONCLUSION: Our data show that @entity1 with @entity17586 -large lesions compared with those with @entity17586 -small lesions have a more favorable disease course and suggest exploring the size of @entity75 as a prognostic parameter in childhood-onset @entity17586 .
