XXXX : analysis of clinical stages.

@entity1 @entity410 @entity2045 @entity15617 @entity739 @entity2473 @entity302 @entity159
PURPOSE: @entity302 is one of the main features of @entity15617 ( @entity15617 ), although it is not described in depth. To determine the spectrum of @entity302 , we studied its main characteristics. METHODS: Based on clinical charts, we retrospectively analyzed the evolution of electroclinical features of 12 @entity1 with confirmed @entity15617 . RESULTS: @entity302 could be divided into three periods: (a) an early stage (median age, 3 months), characterized by focal clonic @entity159 , usually triggered by fever (10 @entity1 ). Ictal EEG showed runs of slow spike-waves and slow waves in the posterior regions, and interictal EEG multifocal and polymorphic slow waves (three cases), or mixed slow spike-waves and slow waves (seven cases). Partial @entity410 control was obtained in nine @entity1 during 5.9 months; (b) an intermediate stage (median age, 10 months) with @entity739 (11 @entity1 ) in which interictal EEG demonstrated modified @entity739 (seven cases), diffuse irregular slow waves and spike-waves (four cases). Six @entity1 died at the median age of 15 months; and (c) a late stage in the six remaining @entity1 (median age, 25 months), with multifocal @entity410 , @entity2473 , and @entity2045 in four @entity1 , whereas two @entity1 became @entity410 free. Interictal EEG showed multifocal high-amplitude activity, mixed with irregular slow waves in all six cases. These @entity1 died at the median age of 3.6 years. CONCLUSIONS: Based on a relatively large series of @entity15617 @entity1 with a quite prolonged survival, we individualized three successive periods in the course of @entity302 : early focal status, then @entity739 , and then @entity2045 and multifocal @entity302 after age 2 years.
