[Combined therapy of advanced XXXX and one-stage repair of the defect].

@entity1 @entity548 @entity5 @entity957 @entity189 @entity418
OBJECTIVE: To evaluate the treatment of advanced @entity957 . METHODS: Eight @entity1 with @entity189 underwent resections combining mandibular ramus and oral cavity approaches, neck dissection and one-stage repair of the defect with pectoralis major myocutaneous flap (PM). The managements were supplemented with preoperative chemotherapy and postoperative radiotherapy. RESULTS: Following up 3 to 9 years, 6 of 8 cases(75%) survived for more than 3 years. Two of 8 cases (25%) died of different causes postoperatively. One case died of serious @entity548 resulted from radio-mandibulomyelitis 3 months after operation, and the other case died of @entity418 2 years after operation. Two cases complicated radio-mandibulomyelitis. Two cases suffered from temporary regurgitation of food to the nasal chamber. CONCLUSIONS: Through this combined approach, the @entity189 could be resected en bloc under direct visual field and keeping 1-1.5 cm safe margin to the @entity5 . Neck dissection, preoperative chemotherapy and postoperative radiotherapy were supplemental measures. Combined therapy was of great significance in reducing recurrence of the @entity5 . PM was usually survived and easily obtained, hence, suitable for repairing the pharyngeal defect.
