[Control of XXXX and complications in long-term streptokinase therapy].

@entity1 @entity548 @entity1003 @entity1151 @entity1150 @entity432 @entity715
Streptokinase was infused for 103 +/- 25 hrs. in 27 @entity1 (6 with @entity1150 of the leg, 7 with @entity715 of Vv. axillaris and subclavia, 9 with @entity1151 , 3 with chronic @entity432 , 2 with @entity715 of the retinal vein). @entity1003 studies were performed repeatedly. Anticoagulation (prolongation of thrombin time to 1 1/2-2 1/2 of normal) could be achieved without additional heparin by reduction of streptokinase to doses as low as 20 000 U/h. Reptilase time correlated significantly with thrombin times. Following 24 hrs. of infusion, PTT was less than 50 sec. and Quick test less than 50% of normal in most instances. No correlation was found between PTT or Quick test and factor II, V, VI, X activities during streptokinase infusion. Bleeding was observed in 18 @entity1 . The infusion was stopped because of @entity548 in 3 cases. None of the coagulation tests performed in this study correlated with the incidence of @entity548 . Hemoglobin concentration decreased 2,6 +/- 1,6 gr% and this decrease could no be explained by blood lesses.
