Comparison of the clinicopathologic features of XXXX and @entity2835 .

@entity2835 @entity1 @entity9849 @entity991 @entity1295 @entity31 @entity111 @entity920 @entity255
@entity991 and @entity2835 are chronic cholestatic syndromes that may be difficult to differentiate clinically. Destructive @entity255 occurs in both diseases and leads to similar clinical and biochemical abnormalities. Therefore, we compared the clinical, biochemical, immunologic, radiologic, and hepatic histologic features of these syndromes in two large groups of @entity1 prospectively selected by predefined criteria. @entity2835 (n = 258) occurred predominantly in middle-aged @entity1 who were usually symptomatic with @entity1295 and @entity111 , commonly had @entity9849 sicca, and often were hyperpigmented. Tests for antimitochondrial antibodies were always positive, usually in very high titer. Although the extrahepatic bile ducts were normal radiographically, smooth tapering and narrowing of the intrahepatic bile ducts was occasionally noted. Hepatic histology was diagnostic when a florid duct lesion was present. In contrast, @entity991 (n = 60) occurred primarily in young @entity1 who were usually symptomatic with @entity1295 and @entity111 and frequently had chronic @entity31 . Tests for antimitochondrial antibodies were nearly always negative and cholangiography demonstrated abnormalities of the extrahepatic and intrahepatic bile ducts in all cases. Although hepatic histology was often compatible with the diagnosis, it was usually not diagnostic, and considerable overlap existed with the abnormalities seen in @entity2835 . Likewise, biochemical tests of @entity920 metabolism were similar in both syndromes. These results call attention to the differences and similarities in the clinicopathologic features of these two cholestatic syndromes and provide a basis for a rational diagnostic strategy.
