Characterization of alterations in plasma lipoprotein lipid and apoprotein profiles accompanying hepatoma-induced XXXX in @entity35 .

@entity407 @entity14839 @entity5 @entity17120 @entity12217 @entity12216 @entity412 @entity7283 @entity35 @entity165
Alterations in plasma lipoprotein lipid and apoprotein accompanying the @entity407 of @entity35 bearing @entity7283 7288C were characterized. In @entity5 -bearing animals all plasma lipid classes except @entity14839 (CE) were elevated, particularly free @entity165 (FC) and @entity412 (TG), which increased by 57 and 63%, respectively. Fasting only partially reduced the @entity5 -induced @entity407 and had no effect on the ratios of FC/CE and TG/CE. Analysis of plasma lipoproteins revealed an elevation of VLDL, IDL, and LDL in host @entity35 , with more than a 2-fold increase in both lipid and protein of VLDL. In contrast, the three high density fractions, @entity17120 , HDL3, and d greater than 1.21 g/ml, were reduced. The inverse changes in concentration of host lipoproteins of lower versus higher density indicate a defective catabolism of TG-rich lipoprotein. This possibility is supported by the analysis of apolipoprotein. The percentage of total apoprotein contributed by apo C-I and C-II was reduced in all host fractions except @entity17120 , while the C-IIIs remained unchanged except for a small decrease in C-III-3 of host VLDL and a slight increase in the combined C-IIIs of @entity17120 . These changes were reflected in the decreased C-I+C-II/C-III ratios of all host lipoprotein fractions. @entity12217 levels remained similar to control values except for a significant decrease in @entity17120 . Host VLDL showed increased @entity12216 and A-I content, while A-IV was decreased in @entity17120 . Changes in apo B profiles were also observed.
