Suppressed diluting segment reabsorption in @entity9475 : studies in 1 XXXX and synthesis of literature data.

@entity1 @entity9475 @entity1219 @entity1372 @entity972
We analyzed renal @entity1372 handling in a @entity1 with @entity9475 after equilibration on diets containing 200 and 700 mmol @entity1219 /day. No @entity972 supplements were given. Clearance studies were performed during maximal water diuresis, maximal free water clearance was taken as measure of diluting segment @entity1372 reabsorption. A normal reference frame of diluting segment @entity1219 reabsorption at varying delivery rates to that segment was drawn from data collected in similarly studied normal subjects after equilibration on low (20 and 200 mmol/day) or very high (916-1,224 mmol/day) @entity1372 intakes. The results were compatible with a defect in diluting segment reabsorption in the @entity1 , which appeared more pronounced during the high @entity1372 intake. Recent reports do not agree with the existence of such a defect in @entity9475 . One of the reasons of this difference may be the lack of a proper reference frame in previously published studies. We, therefore, compared clearance data in adults with @entity9475 published by others with our studies in normals. Our analysis showed that in @entity9475 (1) a moderate diluting segment @entity1219 reabsorption defect is often present, and (2) the proximal reabsorption is frequently elevated relative to @entity1372 intake. Severely suppressed diluting segment reabsorption and relatively low proximal reabsorption may also occur, particularly in association with salt loading or reduced glomerular filtration. It seems, therefore, that much of the continuing controversy on renal @entity1372 handling in @entity9475 may be solved by using the proper frame of reference.
