Outcomes in stage I XXXX following the introduction of stereotactic body radiotherapy in Alberta - A population-based study.

@entity1 @entity1149 @entity5 @entity1349
PURPOSE: To review outcomes of @entity1 with stage I @entity1149 ( @entity1149 ) following the introduction of stereotactic body radiation therapy (SBRT). METHODS: SBRT cases were linked to the @entity5 registry database along with clinical, treatment and health service parameters for n=2146 cases of stage I @entity1149 diagnosed between 2005 and 2011. The pre-diagnosis Aggregated Clinical Risk Grouping score (ACRG3) was used as a proxy for pre-treatment @entity1 comorbidity. A Cox regression model and the concordance statistic (C-statistic) were used to examine variables predicted for @entity1349 ( @entity1349 ). RESULTS: The SBRT utilization rate increased annually with superior @entity1349 to conventional RT (median survival [MS] of 39.4 VS. 23.5months, P<0.001) despite higher ACRG3 scores. Surgical @entity1 were younger, had lower ACRG3, achieving MS of 69.6months. Regression analysis indicated both Surgery (hazard ratio [HR]=0.23, 95% CI: 0.18-0.28) and SBRT (HR=0.33, 95% CI: 0.21-0.51) remained most strongly associated with @entity1349 . ACRG3 (HR=0.79, P<0.001) and age (HR=0.83, P=0.03) were independently associated with @entity1349 . The @entity1349 model was associated with the C-statistic at 0.86, 95% CI: 0.81-0.90. CONCLUSION: In stage I @entity1149 @entity1 treated with surgery have the best survival. SBRT demonstrates improved @entity1349 compared to conventional RT. C-statistic result demonstrates discrimination of treatment selection factors on @entity1349 .
