XXXX plays a critical role in oral, but not dermal, wound healing.

@entity19 @entity34551 @entity5003 @entity5765
Wound healing is a well-orchestrated complex process leading to the repair of injured tissues. After injury, proinflammatory cytokines act as important modulators of the inflammatory process. @entity5003 expression has been regarded as necessary for healing; however, its effects have also been implicated in delayed wound repair. Currently, there is no consensus or direct evidence that @entity5003 activity plays a central role in the healing process. The present investigation was undertaken to define the role of IL-1R signaling in the healing outcome of an excisional wound in the palate or scalp of @entity19 that had targeted deletions of the IL-1 @entity5765 ( @entity34551 (-/-)) compared with matched wild-type @entity19 . Histomorphometric analysis was undertaken to assess the degree of healing and the recruitment of polymorphonuclear and mononuclear phagocytes. After 14 days, wild-type @entity19 exhibited complete closure of intraoral wounds, while @entity34551 (-/-) animals had only partial closure (50%). In the @entity34551 (-/-) @entity19 , healing tissues exhibited a persistent inflammatory cell infiltrate, which did not occur in wild-type animals. Treatment with antibiotics significantly diminished the persistent inflammatory infiltrate and improved healing in the experimental animals. In contrast to oral wounds, the rate of healing and recruitment of polymorphonuclear cells in scalp wounds was similar in @entity34551 (-/-) and wild-type @entity19 . The present data underscore the importance of @entity5003 in wound healing in a challenging environment and identify its principal role in facilitating the healing process by protecting an open wound from bacterial insult. In a less challenging environment, the production of new connective tissue and its coverage by migrating epithelium are minimally affected by the absence of @entity5003 activity.
