@entity10201 viruses associated with community-acquired XXXX in @entity1 : matched case-control study.

@entity1 @entity778 @entity14536 @entity10201 @entity9488 @entity55 @entity15609 @entity497 @entity325
BACKGROUND: @entity497 ( @entity497 ) is the leading cause of death in @entity1 worldwide and a substantial proportion of childhood @entity497 is caused by viruses. A better understanding of the role of @entity778 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity10201 viruses and childhood @entity497 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity1 aged  <=5   years with radiological @entity497 . Healthy controls were consecutively enrolled at @entity1 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity325 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity55 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity10201 were detected in 60% of cases and were significantly associated with @entity497 with ORs >10. There was no association with @entity15609 virus, @entity1 @entity9488 and coronavirus and bocavirus were negatively associated with @entity497 . CONCLUSIONS: Our study indicates viral @entity497 is an underestimated disease and points out @entity14536 as a new important target for the prevention of childhood @entity497 .
