XXXX : A Diabetic Microvascular Complication of Special Clinical, Diagnostic, and Prognostic Importance.

@entity16 @entity8249 @entity4148 @entity3949
UNASSIGNED: Damage of small nerve fibers may lead to a large variety of clinical symptoms. Small-fiber @entity16 underlies the symptoms of @entity3949 , which may decrease quality of life. It also contributes to the poor prognosis of @entity3949 because it plays a key role in the pathogenesis of foot ulceration and @entity4148 . Impairment of small nerve fibers is considered the earliest alteration in the course of @entity3949 . Therefore, assessment of functional and morphological @entity8249 may enable timely diagnosis. The definition, symptoms, and clinical significance of small-fiber @entity16 are considered in the present review. An apparently more complex interaction between small-fiber impairment and microcirculation is extensively discussed. Diagnostic modalities include morphometric and functional methods. Corneal confocal microscopy and punch skin biopsy are considered gold standards, but noninvasive functional tests are also diagnostically useful. However, in routine clinical practice, small-fiber @entity16 is diagnosed by its typical clinical presentation. Finally, prompt treatment should be initiated following diagnosis.
