Oral contraceptive use and XXXX .

@entity1 @entity4383
BACKGROUND _ AIMS: Because most @entity1 with @entity4383 ( @entity4383 ) are young @entity1 , an important decision is whether to discontinue oral contraceptive (OC) use. The aims of this study were to evaluate (1) the number and size of @entity4383 in @entity1 with various patterns of OC use and in @entity1 without OC use and (2) the modifications in the number and size of @entity4383 during follow-up, according to OC use. METHODS: In a 9-year study in 216 @entity1 with @entity4383 , the diameter and number of lesions documented by magnetic resonance (MR) imaging were evaluated (1) at diagnosis according to OC use as follows: group A, no OC use (n = 28); group B, high-dose OC use (n = 46); group C, low-dose OC use (n = 98); group D, successive use of high-dose and low-dose OCs (n = 33); and group E, use of progestogens only (n = 11); and (2) during follow-up in 136 @entity1 , 14 of whom were OC nonusers who stayed off OCs, 89 discontinued OC use, 26 took low-dose OCs, and 7 stayed on a progestogen only. Twelve @entity1 became pregnant. In 168 @entity1 , the diagnosis of @entity4383 was made based on a combination of rigorously defined MR criteria. In the remaining 48 @entity1 , diagnosis was by surgical biopsy (n = 36) or resection (n = 12). Mean diameter and number of lesion(s) per @entity1 were assessed by MR imaging using the same protocol in all study @entity1 . RESULTS: No significant differences in the number or size of lesions were found in the 5 @entity1 groups. During follow-up, a change in lesion diameter occurred in only 4 @entity1 ; this event was not influenced by OC use. In the 12 @entity1 who became pregnant, lesion size was unchanged after delivery, pregnancy was uneventful, and delivery occurred spontaneously. CONCLUSIONS: These data suggest that (1) neither the size nor the number of @entity4383 are influenced by OC use; (2) size changes during follow-up are rare and do not seem to depend on OC use; and (3) pregnancy is not associated with @entity4383 changes or complications.
