Chromogranin positive cells in XXXX and transitional mucosa.

@entity1 @entity5 @entity189 @entity344 @entity14
AIMS: Immunostaining of chromogranin identifies @entity344 cells. The detailed distribution and significance of chromogranin positive cells in @entity14 and in transitional mucosa remain unclear. The aim of this study was to clarify these aspects. METHODS: The distribution of chromogranin positive cells was studied by immunohistochemical methods in normal epithelium remote from @entity189 , in transitional mucosa, and in @entity189 of the colorectum. In selected cases northern or western blot analyses were performed. RESULTS: Chromogranin positive cells were seen in the lower third of the normal crypts and less frequently in transitional mucosa. Thirty five per cent (n = 38) of @entity14 showed immunohistochemically positive @entity189 cells in the @entity5 tissue. Northern and western blot analyses showed similar results. There was no difference in clinicopathological factors, including prognosis, between chromogranin positive cases of @entity14 (n = 38) and chromogranin negative cases (n = 70). CONCLUSIONS: Neuroendocrine cell differentiation is controlled in transitional mucosa and the presence of chromogranin positive cells in @entity189 tissue does not influence the @entity1 's prognosis.
