More Accurate Prediction of Metastatic XXXX @entity1 ' Survival with Prognostic Model Using Both Host Immunity and @entity5 Metabolic Activity.

@entity1 @entity788 @entity419 @entity5 @entity1349
INTRODUCTION: Neutrophil to lymphocyte ratio (NLR) and standard uptake value (SUV) by @entity419 PET represent host immunity and @entity5 metabolic activity, respectively. We investigated NLR and maximum SUV (SUVmax) as prognostic markers in @entity788 ( @entity788 ) @entity1 who receive palliative chemotherapy. METHODS: We reviewed 396 @entity788 @entity1 receiving palliative chemotherapy. NLR was obtained before and after the first cycle of chemotherapy. In 118 @entity1 with PET prior to chemotherapy, SUVmax was collected. Cut-off values were determined by ROC curve. RESULTS: In multivariate analysis of all @entity1 , NLR and change in NLR after the first cycle of chemotherapy (  NLR) were independent prognostic factors for @entity1349 ( @entity1349 ). We scored the risk considering NLR and   NLR and identified 4 risk groups with different prognosis (risk score 0 vs 1 vs 2 vs 3: @entity1349 9.7 vs 7.9 vs 5.7 vs 2.6 months, HR 1 vs 1.329 vs 2.137 vs 7.915, respectively; P<0.001). In PET cohort, NLR and SUVmax were independently prognostic for @entity1349 . Prognostication model using both NLR and SUVmax could define 4 risk groups with different @entity1349 (risk score 0 vs 1 vs 2 vs 3: @entity1349 11.8 vs 9.8 vs 7.2 vs 4.6 months, HR 1 vs 1.536 vs 2.958 vs 5.336, respectively; P<0.001). CONCLUSIONS: NLR and SUVmax as simple parameters of host immunity and metabolic activity of @entity5 cell, respectively, are independent prognostic factors for @entity1349 in @entity788 @entity1 undergoing palliative chemotherapy.
