Curative effect of an XXXX - @entity32495 combination in the postischemic syndrome following transient @entity2806 in @entity235 .

@entity32495 @entity64 @entity27962 @entity2806 @entity235 @entity63 @entity26 @entity519 @entity413 @entity4095
Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient @entity2806 , and the influence of treatment with @entity27962 plus @entity32495 were studied in mongrel @entity235 . 10 min of transient @entity2806 was induced by bilateral clamping of both carotid and vertebral arteries. After declamping, the mean time necessary until cerebral venous @entity4095 (cvPO2) reached a value of 3.6 kPa, threshold for tissue @entity519 , was 80 min. At this time (T0), venous cerebral blood flow (vCBF) and cerebral perfusion pressure (Perf P) were below (60 and 20%, respectively) preischemic values, while cerebral vascular resistance (CVR) and @entity26 and @entity413 extraction rates increased despite a normal cerebral @entity26 consumption (CMRO2). At T0 ventilatory assistance without (control group) or with (treated group) intravenous infusion of @entity27962 plus @entity32495 was applied for 110 min. Between T0 and T110 min, 2 @entity235 died in the control group. During this period vCBF decreased by more than 60% in the control group while it slightly increased in the treated group. A strong decrease in Perf P (40%) and increase in CVR (140%) was observed in the control group while in the treated group Perf P and CVR slightly decreased (14 and 35%, respectively). CMRO2 decreased by 60% in the control group but remained within the normal range in the treated group. The fact that cvPO2 remained constantly below the initial value of 3.6 kPa in the control group and, on contrary, above this value in the group infused with @entity32495 plus @entity27962 indicates that the vCBF improvement leads to an increase in @entity26 supply and is involved in the keeping of the adequacy between flow and metabolism. Our results support the hypothesis that the @entity63 may play an important role in the acute prognosis of @entity64 . They clearly indicate that early cerebral resuscitation by infusion of @entity27962 plus @entity32495 , maintaining @entity26 availability and CBF above initial thresholds, should improve the long-term neurological outcome.
