Metabolic alterations underlying the development of @entity39 in the substantia nigra in XXXX .

@entity410 @entity39 @entity209 @entity15945 @entity302 @entity880 @entity35 @entity159 @entity855
The substantia nigra pars reticulata (SNPR) has previously been shown to undergo tissue @entity39 following @entity159 induced by @entity15945 in the @entity35 . Even if the @entity35 is ventilated, the SNPR develops @entity39 if the @entity302 period lasts more than 30 min. @entity35 brains were frozen in situ after 20 and 60 min of @entity410 activity and after 60 min of @entity410 activity followed by 60 min recovery. Labile energy metabolites were then analyzed in the SNPR and in the periaqueductal grey matter (PAG, control region). In the PAG, the metabolite changes during @entity159 were similar to those reported for cerebral cortex and hippocampus. Measurements showed an unchanged @entity855 content and energy charge (97% and 98% of control, respectively) and an accumulation of @entity880 to 9.2 +/- 0.6 mumol/g in the 60-min group. In the PAG, all metabolites measured had returned to control values after 60 min of recovery. In the SNPR, the perturbation of the energy metabolites was much more pronounced during @entity159 . The concentration of @entity855 decreased to 75 +/- 3%, the energy charge to 91% +/- 12% and the adenylate pool to 86.7 +/- 5.7% of control. @entity880 accumulated to concentrations of 16.1 +/- 1.8 mumol/g and 24.9 +/- 2.3 mumol/g in the 20-min and 60-min groups, respectively. The concentration of @entity880 was still increased above control after 60 min recovery, whereas the concentration of @entity855 and the energy charge were lower than control. The findings demonstrate that sustained and intense neuronal activation can cause @entity209 and thereby lead to @entity39 .(ABSTRACT TRUNCATED AT 250 WORDS)
