[Suppression to @entity1567 xenografts of XXXX embryo @entity231 by tissue inhibitor of metalloproteinases-2].

@entity1 @entity1567 @entity231 @entity47003 @entity5 @entity71879 @entity1573
OBJECTIVE: To explore the invasiveness of xenografts on @entity1573 embryo @entity231 ( @entity231 ) after @entity71879 ( @entity71879 ) gene transfection. METHODS: Fresh @entity1567 tissues were minced into 1-2 mm3 and transplanted on the @entity231 . There were three groups named as control group (Empt), plasma transfection group (Lipo), and @entity71879 gene transfection group (P). The specimens were respectively investigated by microscope indifferent spots after implanting. The volume of the xenografts and the weight of xenografts in the termination time of the experiment were recorded. The invasiveness of xenografts was divided into four grades by pathological examination. Western blot analysis was performed to investigate @entity47003 ( @entity47003 ) and @entity71879 protein in xenografts. RESULTS: @entity1567 tissues can survive on @entity231 and the @entity5 cells may invade it on 5-7 days after implanting. At 9 d after implanting, the invasiveness grades in P group were 7 in grade 0, 1 in grade 2, 0 in grade 3. The expression of @entity71879 protein in P group was significantly higher than that in Empt group (P < 0.05). The expression of @entity47003 protein in P group was lower than that in Empt group (P < 0.05). CONCLUSION: The @entity5 model of @entity1 @entity1567 on @entity231 was successfully established. The invasiveness of @entity1567 xenografts was suppressed might be due to @entity71879 gene transfection.
