Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on XXXX , @entity13270 and @entity13811 .

@entity1 @entity50082 @entity32 @entity13270 @entity64 @entity565 @entity13811 @entity1239 @entity273 @entity148 @entity460 @entity158
Mammals contain 28 genes encoding Transient Receptor Potential (TRP) proteins. The proteins assemble into cationic channels, often with @entity460 permeability. Important roles in physiology and disease have emerged and so there is interest in whether the channels might be suitable therapeutic drug targets. Here we review selected members of three subfamilies of @entity1 TRP channel ( @entity50082 , @entity13270 and @entity13811 ) that show relevance to sensing of adversity by cells and biological systems. Summarized are the cellular and tissue distributions, general properties, endogenous modulators, protein partners, cellular and tissue functions, therapeutic potential, and pharmacology. @entity50082 is stimulated by receptor agonists and other factors that include lipids and metal ions; it heteromultimerises with other TRPC proteins and is involved in cell movement and @entity148 control. @entity13270 is activated by @entity273 ; it is implicated in stress-related inflammatory, vascular and neurodegenerative conditions. @entity13811 is stimulated by a wide range of irritants including mustard oil and @entity1239 but also, controversially, noxious cold and mechanical pressure; it is implicated in @entity158 and inflammatory responses, including in the airways. The channels have in common that they show polymodal stimulation, have activities that are enhanced by redox factors, are permeable to @entity460 , and are facilitated by elevations of intracellular @entity460 . Developing inhibitors of the channels could lead to new agents for a variety of conditions: for example, suppressing unwanted tissue remodeling, @entity32 , @entity158 and @entity148 , and addressing problems relating to @entity565 and @entity64 .
