Temporal patterns of association between cigarette smoking and XXXX risk.

@entity1778 @entity981 @entity1860 @entity1072
OBJECTIVES: To evaluate variation in smoking-related @entity1778 risk with time-since-exposure. METHODS: We analyzed data from a population-based case-control study conducted in Germany. Odds ratios were estimated by applying conditional logistic regression methods to 470 incident @entity1778 cases and 1,009 controls. Cases were classified as @entity981 ( @entity981 ), @entity981 ( @entity981 ), @entity1860 ( @entity1860 ), and @entity1072 ( @entity1072 ). Temporal variation in the impact of smoking on @entity1778 risk was assessed via exposure time-windows and a spline latency function. RESULTS: Current smokers were at greater risk of @entity981 than those who never smoked (OR = 1.65 95% CI: 0.95, 2.87) and a positive trend was observed in @entity981 risk with cumulative pack-decades smoked, under a 2-year exposure lag assumption (OR/pack-decade = 1.11 95% CI: 0.96, 1.30). This was primarily due to the association between @entity981 and smoking in the period 2 to <10 years prior (OR/pack-decade = 2.72 95% CI: 0.93, 7.99). There was minimal evidence of association between @entity981 risk and packs smoked 10 or more years prior. @entity1860 and @entity981 exhibited minimal evidence of association with smoking status. @entity1072 exhibited a positive association with smoking in the periods 2 to <10 years and 10 to <20 years prior to diagnosis although estimates of association were highly imprecise. CONCLUSIONS: The temporal pattern of smoking-induced @entity981 risk appears to follow a prompt peak in excess incidence that diminishes with time since exposure.
