XXXX and @entity6126 are associated with an increased risk of predominant Gleason 4 pattern on radical prostatectomy specimen.

@entity1 @entity251 @entity263 @entity28 @entity11179 @entity6126
PURPOSE: To compare histological features of @entity263 according to both @entity28 , defined by a body mass index (BMI) >= 30 kg/m2, and androgenic status in @entity1 who underwent radical prostatectomy. MATERIALS AND METHODS: Between March 2007 and September 2013, clinical, pathological and biological data were prospectively collected for @entity1 referred for radical prostatectomy in a single European center. Preoperative total @entity251 (TT) and bioavailable @entity251 (bioT) serum determinations were performed. The threshold for @entity6126 was set at TT <3 ng/mL. The preoperative @entity11179 value was registered. Gleason score (GS) and predominant Gleason pattern (PrdGP) were determined in prostate tissue specimens, and crosschecked by two uro-pathologists. Statistical analyzes were done for PrdGP4 risk assessment. RESULTS: A total of 937 consecutive @entity1 were included. One hundred and thirty-five filled the criterion for @entity28 (14.4%), out of which 42 had TT <3 ng/mL (31.1%), while in non- @entity28 @entity1 , only 97 had TT <3 ng/mL (12.0%). In prostate specimens, mean GS was 6.8  0.5: 291 @entity1 (31.1%) had a PrdGP4. The incidence of PrdGP4 was higher (p<0.001) in the 135 @entity28 @entity1 [50% when hypogonadal (p<0.02) or 42% when eugonadal (p<0.005)] than in non- @entity28 @entity1 (28.9% and 27.1%, respectively). In multivariable analyzis for PrdGP4 risk, @entity28 , TT <3 ng/mL, @entity11179 , and age were independent risk factors. CONCLUSIONS: Both @entity28 and @entity6126 are independent risk factors for PrdGP4 in @entity1 who underwent radical prostatectomy and should be taken into account in @entity263 management, to improve the therapeutic choice, especially when prostate sparing approach is considered.
