Early-phase differences in health-related quality of life, XXXX , and physical function between human leucocyte antigen-haploidentical and other allogeneic haematopoietic stem cell transplantation recipients.

@entity1 @entity308 @entity159
PURPOSE: This study investigated the differences between allogeneic haematopoietic stem cell transplantation (allo-HSCT) @entity1 receiving HSC from human leucocyte antigen (HLA)-haploidentical donors (HID) and other donors that included HLA-matched sibling, matched unrelated, and unrelated umbilical cord blood donors in the 6 weeks after HSCT with respect to quality of life (QOL), @entity159 , and physical function. METHODS: The study included 126 @entity1 (HID group, n  =  100; other donor group, n  =  26) who underwent allo-HSCT between July 2007 and December 2012. @entity1 were evaluated for health-related QOL using the Medical Outcome Study 36-item Short Form Health Survey. Psychological status was measured by Hospital Anxiety and @entity308 Scale. Physical function was assessed using tests for handgrip strength, knee extensor strength, and the 6-min walk test. RESULTS: After HSCT, the HID group showed significantly greater improvements in the general health subscale and Mental Component Summary (MCS) of QOL than the other donor group (P  <  0.01). Multivariate analysis confirmed that complete remission and age were associated with changes in the general health subscale before and after HSCT (P  <  0.05). With regard to physical function, the HID group showed significantly more decline than the other donor group with respect to handgrip strength and knee extensor muscle strength after HSCT (P  <  0.05). Total corticosteroid dose was associated with decreased handgrip strength before and after HSCT (P  <  0.05). CONCLUSIONS: The donor type affects QOL, @entity159 , and physical function in allo-HSCT recipients; these findings may provide insights for customised rehabilitation strategies for HSCT recipients.
