Evaluation of an asymmetric stent patch design for a XXXX specific @entity438 using Computational Fluid Dynamic ( @entity5173 ) calculations in the Computed Tomography (CT) derived lumen.

@entity1 @entity5173 @entity439 @entity397 @entity438
Stenting may provide a new, less invasive therapeutic option for @entity438 . However, a conventional porous stent may be insufficient in modifying the blood flow for clinical @entity439 . We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an @entity438 of a specific @entity1 geometry to block the strong inflow jet. To evaluate the effect of the patch on aneurysmal flow dynamics, we "virtually" implanted it into the @entity1 's @entity439 geometry and performed @entity5173 ( @entity5173 ) analysis. The patch was computationally deformed to fit into the vessel lumen segmented from the @entity1 CT reconstructions. After the flow calculations, a patch with the same design was fabricated using laser cutting techniques and welded onto a commercial porous stent, creating a @entity1 -specific asymmetric stent. This stent was implanted into a phantom, which was imaged with X-ray angiography. The hemodynamics of untreated and stented @entity439 were compared both computationally and experimentally. It was found from @entity5173 of the @entity1 @entity439 that the asymmetric stent effectively blocked the strong inflow jet into the @entity439 and eliminated the flow impingement on the @entity439 wall at the dome. The impact zone with elevated wall shear stress was eliminated, the aneurysmal flow activity was substantially reduced, and the flow was considerably reduced. Experimental observations corresponded well qualitatively with the @entity5173 results. The demonstrated asymmetric stent could lead to a new minimally invasive image guided intervention to reduce @entity439 growth and @entity397 .
