Activation of Peroxisome Proliferator-Activated Receptor y (PPARy) Through @entity4026 / XXXX and @entity1810 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded @entity35 Hearts.

@entity71889 @entity82 @entity101 @entity1184 @entity1808 @entity1810 @entity299 @entity35 @entity583 @entity4026
BACKGROUND/AIMS: Cardiac remodeling is a common pathophysiological change along with chronic @entity101 and @entity583 . Recent evidence indicated that cardiac tissue expressed peroxisome proliferator-activated receptor y (PPARy). However, the functional role of PPARy in @entity299 remained unclear. The present study was designed to investigate the relationship between PPARy activation and pressure overload-induced @entity299 . METHODS: Cardiac remodeling model was successfully established by abdominal aorta ligation. Cardiac @entity82 and cardiomyocyte @entity1184 were simulated by 100 nM @entity1808 ( @entity1808 ) in vitro. Haemodynamic parameters, the expressions of @entity71889 , a-MHC, b-MHC, @entity1810 ( @entity1810 ), collagen-I, collagen-III and @entity4026 were examined. RESULTS: Morphological and haemodynamic measurements showed that the activation of PPARy improved the @entity299 and decreased interstitial @entity82 in @entity299 @entity35 . Further results also showed that the activation of PPARy inhibited the expressions of @entity71889 and @entity1810 in the @entity299 . The activation of PPARy also inhibited the proliferation and collagen production of cardiac fibroblasts, and down-regulated the activity of @entity71889 and the expression of @entity1810 induced by @entity1808 in cultured neonatal @entity35 cardiomyocytes and cardiac fibroblasts, respectively, through @entity4026 pathway. CONCLUSIONS: These results suggested that PPARy activation effectively inhibited @entity299 processes by suppression of @entity71889 and @entity1810 expressions through @entity4026 pathway in the pressure-overloaded hearts induced by abdominal aorta ligation in @entity35 .    2015 S. Karger AG, Basel.
