@entity40725 is implicated in the cardioprotective activity of @entity33448 XXXX against @entity3044 -induced myocardial fibrogenesis.

@entity296 @entity82 @entity19 @entity3857 @entity33448 @entity40725 @entity8670 @entity3044 @entity65
ETHNOPHARMACOLOGICAL RELEVANCE: @entity33448 (Burkill) F.H. Chen (Araliaceae) has a long history of clinical application in China for the treatment of @entity65 . @entity33448 @entity3857 (PNS) have been proven to be the major cardioprotective substances of @entity33448 (Burkill) F.H. Chen (Araliaceae). AIM OF THE STUDY: The current study further investigated the molecular mechanisms associated with the cardioprotective effect of PNS. MATERIALS AND METHODS: C57BL/6J @entity19 were subject to @entity3044 ( @entity8670 )-induced @entity296 in the absence or presence of PNS treatment. Histological, immunohistochemical and molecular biological approaches were taken to assess the effects of PNS treatment on @entity8670 -induced @entity296 and ensuing fibrogenesis. RESULTS: PNS treatment significantly attenuated @entity8670 -induced @entity296 and @entity82 . The expression of an anti-fibrotic microRNA, @entity40725 , was significantly decreased in @entity8670 -challenged @entity19 hearts. In contrast, PNS treatment resulted in increased cardiac expression of @entity40725 . The expression of @entity40725 target genes including Collagen (Col) 1a1, Col1a2, Col3a1 and Col5a1, fibrillin 1 (Fbn1) as well as TGFb1 was significantly increased by @entity8670 , which exhibited decreased expression by PNS intervention. CONCLUSIONS: Our results demonstrate for the first time that the cardioprotective effects of PNS could in part implicate increased expression of @entity40725 in the heart, which may help increase the understanding of the pharmacological activities of PNS in treating @entity65 .
