Bioassay of XXXX for possible carcinogenicity (CAS No. 99-55-8).

@entity2695 @entity19 @entity5 @entity5426 @entity35 @entity157 @entity72283
A bioassay of @entity72283 for possible carcinogenicity was conducted using Fischer 344 @entity35 and B6C3F1 @entity19 . @entity72283 was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The time-weighted average high and low dietary concentrations of @entity72283 were, respectively, 0.01 and 0.005 percent for @entity35 , and 0.23 and 0.12 percent for @entity19 . After a 78-week period of compound administration, observation of the @entity35 continued for an additional 30 to 31 weeks and observation of the @entity19 continued for up to an additional 20 weeks. For each species, 50 animals of each sex were placed on test as controls and fed only the basal diet. There were no significant positive associations between the concentration of @entity72283 administered and mortality in @entity35 or @entity19 of either sex, and adequate numbers of animals in all groups survived sufficiently long to be at risk from late-developing @entity5 . No @entity5 were observed in @entity35 of either sex and no convincing statistical evidence was provided for a significant positive association between compound administration and the incidence of any @entity5 in @entity35 . Among @entity19 there was a statistically significant positive association between administration of the chemical and the incidences of @entity157 in both males and females. The combined incidence of @entity2695 and @entity5426 in male @entity19 and the incidence of @entity5426 in female @entity19 were not statistically significant in relation to their respective control groups. However, they were considered to be associated with compound administration since they rarely occur in untreated B6C3F1 @entity19 . Under the conditions of this bioassay @entity72283 was carcinogenic in B6C3F1 @entity19 , causing @entity157 in both sexes, an increase in the combined incidence of @entity2695 and @entity5426 in male @entity19 , and an increased incidence of @entity5426 in female @entity19 . The compound was not carcinogenic in Fischer 344 @entity35 .
