Prognostic Significance of Serum Alkaline Phosphatase Level in XXXX : A Meta-Analysis of Published Data.

@entity1 @entity5 @entity421 @entity3 @entity1349
Background. Serum alkaline phosphatase (SALP) is commonly elevated in @entity421 @entity1 . A number of studies have investigated the prognostic role of SALP level in @entity1 with @entity421 but yielded inconsistent results. Method. Systematic computerized searches were performed in PubMed, Embase, and Web of Science databases for relevant original articles. The pooled hazard ratios (HRs) and relative risks (RRs) with corresponding confidence intervals (CIs) were calculated to assess the prognostic value of SALP level. Results. Finally, 21 studies comprising 3228 @entity1 were included. Overall, the pooled HRs of SALP suggested that elevated level had an unfavorable impact on @entity421 @entity1 ' @entity1349 ( @entity1349 ) (HR = 1.82; 95% CI: 1.61-2.06; p < 0.001) and event-free survival (EFS) (HR = 1.97; 95% CI: 1.61-2.42; p < 0.001). Combined RRs of SALP indicated that elevated level was associated with presence of @entity3 at diagnosis (RR = 5.55; 95% CI: 1.61-9.49; p = 0.006). No significantly different results were obtained after stratified by variables of age range, @entity5 stage, sample size, and geographic region. Conclusion. This meta-analysis demonstrated that high SALP level is significantly associated with poor @entity1349 or EFS rate and presence of @entity3 at diagnosis. SALP level is a convenient and effective biomarker of prognosis for @entity421 .
