@entity6288 , intramuscular fat deposition, and @entity10478 independently predict the outcomes of XXXX .

@entity1 @entity10478 @entity28 @entity5 @entity6288 @entity157
BACKGROUND _ AIMS: Obesity defined by body mass index (BMI) significantly increases the risk of @entity157 ( @entity157 ). In contrast, not only @entity28 but also underweight is associated with poor prognosis in @entity1 with @entity157 . Differences in body composition rather than BMI were suggested to be true determinants of prognosis. However, this hypothesis has not been demonstrated conclusively. METHODS: We measured skeletal muscle index (SMI), mean muscle attenuation (MA), visceral adipose tissue index, subcutaneous adipose tissue index, and visceral to subcutaneous adipose tissue area ratios ( @entity10478 ) via computed tomography in a large-scale retrospective cohort of 1257 @entity1 with different stages of @entity157 , and comprehensively analyzed the impact of body composition on the prognoses. RESULTS: Among five body composition components, low SMI (called @entity6288 ), low MA (called intramuscular fat [IMF] deposition), and high @entity10478 (called @entity10478 ) were significantly associated with mortality, independently of @entity5 stage or @entity1 -Pugh class. A multivariate analysis revealed that @entity6288 (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.18-1.96; p=0.001), IMF deposition (HR, 1.34; 95% CI, 1.05-1.71; p=0.020), and @entity10478 (HR, 1.35; 95% CI, 1.09-1.66; p=0.005) but not BMI were significant predictors of survival. The prevalence of poor prognostic body composition components was significantly higher in underweight and @entity28 @entity1 than in normal weight @entity1 . CONCLUSIONS: @entity6288 , IMF deposition, and @entity10478 independently predict mortality in @entity1 with @entity157 . Body composition rather than BMI is a major determinant of prognosis in @entity1 with @entity157 .
