Factors affecting pregnancy outcomes in young @entity1 treated with fertility-preserving therapy for well-differentiated endometrial cancer or XXXX .

@entity1 @entity11796 @entity7288 @entity5 @entity3443 @entity1478 @entity1869 @entity4348
BACKGROUND: @entity1 hoping to preserve their fertility receive conservative treatment with high-dose @entity11796 ( @entity3443 ) for well-differentiated @entity4348 ( @entity4348 ) or @entity1869 ( @entity1869 ) . Such treatment generally involves frequent intrauterine operations, including dilation and curettage (D_C) and endometrial biopsy (EMB), which could result in @entity7288 , endometrial thinning, or intrauterine adhesion. In turn, any of these outcomes could adversely affect implantation and pregnancy development. The current study thus aimed to identify factors that might affect pregnancy following conservative treatment by @entity3443 . METHODS: We compared a pregnancy group (45 @entity1 ) with a non-pregnancy group (53 @entity1 ) of @entity3443 -treated @entity1 to evaluate the factors affecting clinical pregnancy establishment. We undertook a multivariate logistic regression analysis based on factors shown by univariate analysis to be significantly different between the groups. Univariate analysis identified number of D_C, endometrial thickness, duration of @entity3443 administration, age of pregnancy permission (the age at which a @entity1 was first allowed to attempt pregnancy after disappearance of the lesion), period of disappearance of lesions, and recurrence as independent variables. RESULTS: The odds ratios (95  % confidence interval) of multivariate analysis for disease recurrence, @entity1478 , and age of pregnancy permission were 0.283 (0.102-0.785), 1.677 (1.251-2.248), and 0.889 (0.792-0.998), respectively. There was no significant difference in the other independent variables between groups. CONCLUSIONS: We identified three factors considered to affect pregnancy establishment following conservative treatment with @entity3443 : recurrence, @entity1478 , and the age of the pregnancy permission. Introduction of infertility treatment including assisted reproductive technology (ART) soon after achieving @entity5 disappearance by @entity3443 would therefore be beneficial for @entity1 with disease recurrence, thin endometrium, or a higher age of pregnancy permission.
