High levels of phosphatase and tensin homolog expression predict favorable prognosis in @entity1 with XXXX .

@entity1 @entity5 @entity957 @entity1149 @entity983 @entity420
OBJECTIVE: The prognostic role of phosphatase and tensin homolog ( @entity983 ) in @entity1149 ( @entity1149 ) has been controversial. @entity1 AND METHODS: In this study, levels of @entity983 expression were investigated in @entity1149 @entity1 and their prognostic value in @entity1149 was assessed. @entity983 expression in @entity5 tissues from 68 @entity1149 @entity1 was analyzed using immunohistochemistry and confocal microscopy. Survival analysis was performed using the log-rank test and Cox proportional hazards regression analysis. RESULTS: @entity1149 @entity1 classified as expressers of high levels of @entity983 (n = 46) had better prognoses than those classified as expressers of low levels (mean survival 17.1 versus 12.9 months, log-rank p = 0.038). In @entity1 with @entity420 ( @entity420 ), high @entity983 expression (n = 9) was associated with significantly longer survival than low @entity983 expression (mean survival 23.50 versus 15.54 months, log-rank p = 0.043). High levels of @entity983 expression resulted in 43% reduction in risk for all @entity1149 @entity1 (HR = 0.57, 95% CI: 0.33-0.98, p = 0.041). @entity983 expression and clinical stage remained significantly associated with survival after adjustment for age, sex and @entity5 type (HR = 0.56, 95% CI: 0.32-0.99; p = 0.048; HR = 0.54, 95% CI: 0.36-0.97; p = 0.045). No significant difference in continuous @entity983 expression levels was observed among groups with different clinical or pathological characteristics (p > 0.17). When levels of @entity983 expression were binarized using the optimal cutpoint, higher levels of @entity983 expression were observed in @entity1 with T1/T2 than in those with T3/T4 (80% and 58% respectively, p = 0.049) and in @entity1 with @entity420 than in those with @entity957 ( @entity957 ) (78% and 58% respectively, p = 0.08). No significant difference in binarized @entity983 expression levels was found among groups with any other clinical/pathologic characteristic (p > 0.28). CONCLUSIONS: Our results suggest that high levels of @entity983 expression may be favorable prognostic marker in @entity1149 @entity1 .
