Correlates of Segmental Pulse Wave Velocity in Older Adults: The XXXX Risk in Communities (ARIC) Study.

@entity122 @entity455 @entity1674 @entity731 @entity65 @entity165
BACKGROUND: Carotid-femoral @entity122 (cfPWV) is a well-established measure of central arterial stiffness, while brachial-ankle @entity122 (baPWV) is being used more frequently in East Asian countries. Few studies have simultaneously characterized the distributions and correlates of segment-specific @entity122 measures and their associations with cardiovascular risk factors. METHODS: We evaluated segment-specific @entity122 (cfPWV, baPWV, and femoral-ankle (faPWV)) in 4,974 older-aged African American and Caucasian adults in the community-based @entity731 Risk in Communities (ARIC) Study using a standardized protocol and the OMRON VP-1000 Plus system. We examined the distribution and multivariable-adjusted correlates of @entity122 measures by race and sex. RESULTS: Mean age ranged from 74  5 to 76  5 years across race-sex groups. In all race-sex groups, cfPWV correlated with baPWV but not with faPWV, and cfPWV and baPWV were higher with age, whereas faPWV was not. Heart rate and systolic blood pressure (SBP) were positively associated and weight was negatively associated with all @entity122 measures; however, the associations with age, glycated hemoglobin, @entity1674 , and high-density lipoprotein (HDL) @entity165 varied by segment and race-sex group. CONCLUSIONS: Our findings indicate that cfPWV and faPWV reflect distinct aspects of segment-specific @entity455 and their associated profile of cardiovascular risk factors. Even among older adults, age is associated with higher cfPWV and baPWV, but not with faPWV. Understanding factors that ostensibly play a role in increasing arterial stiffness in different arterial territories can inform opportunities for @entity65 ( @entity65 ) prevention and risk management.
