XXXX and hyponatraemia.

@entity1 @entity1372 @entity5011 @entity2286
BACKGROUND: Hyponatraemia is a recognized association of the @entity5011 ( @entity5011 ) and is also known to occur after the administration of intravenous infusion of gamma globulin (IVIG), a treatment often used in management of @entity5011 . AIMS: To document serum @entity1372 concentration in @entity5011 @entity1 before, during and after management procedures (including IVIG) positive pressure ventilation ( @entity2286 ) and the use of medications capable of causing a low serum @entity1372 . To consider whether pseudohyponatraemia might be a contributory factor. To assess whether hyponatraemia is a predictor of poor outcome. METHODS: Clinical record audit of 84 @entity1 with @entity5011 admitted to Christchurch Hospital, New Zealand, over a 10-year period. RESULTS: Serum @entity1372 concentration was significantly low (<133 mmol/L) in 26 of 84 (31%) @entity1 . In 12 of these cases the hyponatraemia developed during or after IVIG, suggesting that pseudo-hyponatraemia was a contributing factor. Six (7%) significantly hyponatraemic @entity1 died, but no eunatraemic or slightly hyponatraemic @entity1 died (P = 0.001). Six of 38 @entity1 aged > or =50 years died, whereas none of the 46 @entity1 aged <50 years died (P = 0.007). Five of 19 ventilated @entity1 died but only one of 65 non-ventilated died (P = 0.002). CONCLUSIONS: Significant hyponatraemia occurred in 26 (31%) of the @entity1 , but in 12 of these it appeared likely that pseudohyponatraemia caused by IVIG was a contributing factor. Hyponatraemic @entity1 have a poorer prognosis than eunatraemic @entity1 , however it is difficult to separate this factor from other poor prognostic factors (older age and @entity2286 ).
