Effect of XXXX on the cell cycle of @entity11748 .

@entity19 @entity665 @entity1778 @entity11748 @entity1500 @entity1499
The influence of @entity1499 ( @entity1500 ) on the proliferative activity of cells in different phases of cell cycle has been studied. @entity1500 (5 mg/kg) was injected i.p. 3 days after the inoculation of 5 X 10(6) @entity1778 cells, into F1 (DBA X C57 BL) @entity19 . It was shown that @entity1500 causes degeneration of cells, being in G1- as well as in S-phase at the time of drug injection. Incorporation of @entity665 was suppressed for a period ranging from 2 to 12 hr after @entity1500 administration, which is demonstrated by the decrease in the number of grains per cell. The number of cells labeled after 3H-TdR injection was also sharply decreased during this period. For a period of 3 until 15 hr after @entity1500 administration the mitotic index decreased significantly as a result of inhibition of DNA synthesis. The blocking of the G1-S transition was evident during 4 hr after @entity1500 . Thereafter the G1-S transition proceeds at a rate which is practically equal to that for nontreated controls. @entity1500 did not inhibit transition to mitosis of cells being in G2-phase and in a very late S-phase at the time of drug injection. The sensitivity of G1-cells to the cytocidal effect of @entity1500 shows that for @entity11748 cells @entity1500 can be classified as a cycle-specific drug killing both G1-and S-cells rather than S-phase specific agent with self-limitation.
