[ XXXX --evolutive panorama of diagnosis and treatment in the last forty years].

@entity1 @entity6283 @entity50567 @entity16 @entity2361 @entity2360 @entity1575
In 1912, Wilson and Fleischer independently reported autopsied @entity1 with progressive @entity16 associated with @entity1575 , and they proposed that the syndrome could be a specific disease of toxic origin. In 1952, Scheinberg demonstrated a deficiency of serum ceruloplasmin in @entity2360 , and it became possible to diagnose the illness while the @entity1 was still asymptomatic. In 1956, Walshe introduced @entity2361 as the most excellent drug for treatment of the disease. These epoch-making discoveries encouraged Japanese physicians to make early diagnosis and to try prevention of the disease. This lecture was to review the changing panorama in the diagnosis, treatment and prognosis of the disease in the period of forty years focusing on the experiences in Japan. Early detection of the @entity1 based on @entity50567 made it possible to investigate the onset ages of an elevation of serum GOT or @entity6283 and the appearance of Kayser-Fleischer (KF) rings. So far, the youngest @entity1 who exhibited high @entity6283 level and KF rings were three years and five years old, respectively. It became popular that an unexpected elevation of serum transaminase in apparently healthy @entity1 of three years or more prompted to examine the possibility of @entity2360 , and an increasing number of non-familial @entity1 in late infancy have been detected. Now, the mass-screening for @entity2360 is in progress. Follow-up studies on the prophylaxis for more than thirty years definitely proved that the appearance of clinical symptoms was prevented with the continued @entity2361 therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
