Pulsatile versus steady-state component of blood pressure in elderly females: an independent risk factor for XXXX ?

@entity1 @entity101 @entity1674 @entity1372 @entity65
OBJECTIVE: To evaluate whether the pulsatile component of blood pressure can be a risk factor independent of the steady component in elderly females. DESIGN: Fifty-two elderly @entity101 female @entity1 were compared with 32 normotensive control subjects of the same age. According to the results of that first study, a cohort of 126 elderly females was studied over a 3-year period to evaluate whether the pulsatile and steady-state components of blood pressure correlated with the same parameters and could predict the occurrence of @entity65 . RESULTS: In the first study the @entity101 @entity1 with elevated pulse pressure had significantly higher @entity1674 level and lower urinary @entity1372 excretion than the @entity101 @entity1 with lower pulse pressure and than the control subjects of the same age. The incidence of @entity65 over a 3-year period was significantly higher in the elderly @entity101 females with increased pulse pressure. In the cohort of 126 females mean arterial pressure (MAP) and pulse pressure did not show the same degree of correlation with the biological parameters tested (plasma @entity1674 : MAP r = 0.162, P < 0.05; pulse pressure r = 0.314, P < 0.0005; urinary @entity1372 excretion: MAP r = -0.365, P < 0.0001; pulse pressure r = -0.257, P < 0.002). Furthermore, for the same MAP level, @entity1 with @entity65 in a 3-year period had significantly higher pulse pressure values. Pulse pressure (and not MAP) was a strong predictor of @entity65 . CONCLUSIONS: In elderly @entity101 females the pulsatile and the steady-state components of blood pressure did not correlate with the same biological parameters. Furthermore, the pulsatile component, when explored by pulse pressure, seemed to be a strong independent @entity65 factor.
