@entity1312 protects @entity19 intestine from XXXX and reperfusion injury through regulation of innate and adaptive immunity.

@entity1944 @entity308 @entity63 @entity19 @entity2047 @entity1750 @entity15369 @entity9094 @entity58 @entity1379 @entity1312 @entity1990 @entity10957 @entity26667
BACKGROUND: @entity63 -reperfusion (I/R) injury is a major factor leading to @entity1944 or graft loss after intestinal surgery or transplantation. This study investigated the cytoprotective effects and putative mechanisms of interleukin (IL)-13 after intestinal I/R injury in the @entity19 . METHODS: @entity19 warm intestinal I/R injury induced by clamping the superior mesenteric artery for 100 min with tissue analysis at 4 and 24 hr after reperfusion. Treated animals received intravenous recombinant @entity19 @entity1312 ( @entity10957 antibody, whereas controls received saline. RESULTS: @entity10957 administration markedly prolonged animal survival (100% vs. 50% in saline controls) and resulted in near normal histopathological architecture. @entity10957 treatment also significantly decreased myeloperoxidase activity. @entity19 conditioned with @entity10957 had a markedly @entity308 @entity1990 expression and increased the expression of @entity9094 , antioxidant hemeoxygenase-1, and antiapoptotic A20, @entity1379 / @entity26667 , compared with that of controls. Unlike in controls, the expression of mRNA coding for @entity2047 /interferon-y, and @entity15369 / @entity1750 remained @entity308 , whereas that of @entity1312 / @entity58 reciprocally increased in the @entity19 treated with @entity10957 . Administration of anti- @entity1312 antibody alone or in combination with @entity10957 resulted in outcomes similar to that seen in controls. CONCLUSIONS: This study demonstrates for the first time that @entity1312 plays a protective role in intestinal warm I/R injury and a critical role in the regulation of @entity9094 and @entity1990 signaling. The administration of @entity1312 exerts cytoprotective effects in this model by regulating innate and adaptive immunity while the removal of @entity1312 using antibody therapy abrogates this effect.
