Association between @entity1199 / XXXX and @entity31694 polymorphisms and risk of celiac disease: a meta-analysis.

@entity1593 @entity12549 @entity71062 @entity15787 @entity31703 @entity1199 @entity792 @entity31694
UNASSIGNED: @entity1593 ( @entity1593 ) is a common @entity792 characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of @entity1199 / @entity15787 ( @entity12549 and @entity71062 ) and @entity31694 ( @entity31703 ) may influence susceptibility to @entity1593 , although the effects remain unclear. We performed a meta-analysis of the associations between @entity12549 , @entity71062 , and @entity31703 polymorphisms and @entity1593 risk. PubMed, EMBASE, and the China National Knowledge Infrastructure were searched. ORs and 95%CIs of each single nucleotide polymorphism (SNP) were estimated using the fixed-effect model if I(2) < 50% in the test of heterogeneity; otherwise, the random-effect model was used. Our meta-analysis included 12,986 @entity1593 cases and 28,733 controls from 16 independent samples, and the analysis of each SNP contained a subset of the total. We found that the minor allele T of both @entity12549 (T vs G, OR = 0.72, 95%CI = 0.67-0.78, P < 0.001) and @entity71062 (T vs C, OR = 0.76, 95%CI = 0.71-0.83, P < 0.001) in @entity1199 / @entity15787 significantly decreased the risk of @entity1593 . However, the minor allele A of @entity31703 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in @entity31694 significantly increased @entity1593 susceptibility. The estimated lambda values were 0.49, 0.50, and 0.53 for @entity12549 , @entity71062 , and @entity31703 , respectively, suggesting that a co-dominant model of genotype effect was most appropriate for the three SNPs. Our results support associations between the three SNPs and @entity1593 and provide a strong argument for further research.
