[Early fundus changes caused by repeated small crises in the XXXX : a model for @entity726 simplex].

@entity129 @entity75 @entity16 @entity726 @entity751
In @entity751 a repeated crisis of intraocular pressure (IOP) elevation to 25-45 mmHg continues for 3-10 days. During the relapses @entity16 often occurs. The IOP and its variation during the crisis are similar to those in @entity726 simplex. Therefore, the syndrome can be considered as a natural model for investigations into @entity726 simplex. By analyzing five cases of @entity751 in which the @entity75 ranged from the earliest to advanced stages, the development and progression of @entity16 of the optic nerve at varying chronically elevated IOP levels became evident. The earliest evident fundus change is a @entity129 ( @entity129 ) in the Bjerrum tangent, and not the enlargement of the physiologic excavation. The latter does not develop before stage IV. The slit-like @entity129 shows a decrease in sensitivity of 0.2-0.4 log ND unit, which is thus easily overlooked. As the disease progresses the @entity129 becomes more pronounced, its width increases and it becomes wedge-shaped. Due to a considerable loss of nerve fibers at the wedge-shaped defect, a small notch which develops in the direction of @entity129 is not observed until stage IV. Goldmann perimetry demonstrated a certain abnormality at stages IV-V; in addition to the wedge-shaped @entity129 , diffuse thinning of the @entity129 begins around the optic disk and develops into a large, concentric excavation. For identification of the most delicate NFLDs, stereo fundus photography in color with 8-fold magnification, on 6 x 6 film is recommended.
