[Central @entity551 effects of @entity1774 in anaesthetised XXXX (author's transl)].

@entity308 @entity101 @entity5829 @entity5521 @entity95 @entity551 @entity1338 @entity1063 @entity1774 @entity2955 @entity1168
The effects of intracerebroventricular (i.c.v.) injection of @entity1774 , a new antihypertensive agent, on blood pressure and heart rate were investigated and compared with those of @entity1338 in anaesthetized @entity95 . The i.c.v. injection of @entity1774 or @entity1338 induced a decrease in blood pressure and heart rate in doses which were ineffective by an intravenous route. The @entity308 effect of @entity1774 was less than that of @entity1338 , but the duration of this action was obviously longer than that of @entity1338 . A fall in heart rate caused by @entity1774 was always less conspicuous than that by @entity1338 in equipotent @entity101 doses. Decrease in blood pressure and heart rate caused by the two drugs were inhibited by i.c.v. pretreatment with @entity5521 and @entity2955 , respectively. These findings suggest that presynaptic and/or postsynaptic alpha-adrenoceptors in the brain may play an important role in the @entity551 and @entity1168 produced by @entity1774 as well as @entity1338 . Furthermore, the uptake mechanism at the presynaptic sites of central noradrenergic neurons may be involved in the mode of @entity551 and bradycardic actions of these two drugs since these effects were abolished by pretreatment with @entity5829 , an inhibitor of @entity1063 uptake into the presynaptic nerve terminals.
