XXXX Is Present in De Quervain Disease-Correlation Study Between Biochemical and Histopathological Evaluation.

@entity1 @entity32 @entity82 @entity8806
BACKGROUND: De @entity8806 is a stenosing condition of the sheath of the abductor pollicis longus and extensor pollicis brevis tendons at the radial styloid process. Previous studies consistently reported that the pathological change of this condition is thought to be primarily an extensor retinaculum thickened by @entity82 and angiogenesis instead of @entity32 . Contradictorily, the conservative treatment for de @entity8806 is anti-inflammatory medication. The inflammatory response may be involved in this disease; however, there is no present study directly evidencing whether the inflammatory responses exist in de @entity8806 or not. The histopathology of de @entity8806 is yet to be elucidated clearly. PURPOSE: To grade all specimens in the different stages and characterize specific inflammatory cell and factors to examine whether inflammatory response is involved in de @entity8806 . METHODS: Retinaculum samples were collected from 13 @entity1 with de @entity8806 after surgery. The specimens were evaluated histologically by collagen structure grading and immunohistochemically by quantifying the presence of neutrophil elastase, macrophages, cyclooxygenase, and vascular endothelium. RESULTS: Neutrophil elastase and cyclooxygenase occur in the de @entity8806 retinaculum and increased with the grade of collagen structure. After angiogenesis, macrophage infiltration occurs in the grade II matrix worse than grade III matrix. CONCLUSIONS: @entity32 is present in de @entity8806 . This study provides direct evidence for inflammatory cell and infiltration factors and offer valuable clues for specific pharmacological therapies for de @entity8806 .
