Cardiorespiratory function and pathological findings in XXXX reimplanted after hypothermic preservation.

@entity63 @entity235 @entity73 @entity616 @entity515 @entity2507 @entity972 @entity7634
A good result from the heart-lung transplantation depends on the quality of the preservation of cardiopulmonary transplants. To determine the functional and pathological status of the @entity616 after preservation for several hours, we performed 10 heterologous heart-lung transplantations in @entity235 (weight 13.5 kg) under extracorporeal circulation. Weight and length compatibility between donor and receiver was ensured. Measurements of hemodynamics, lung mechanics and blood gases were performed in the donor and in the receiver before the transplantation, and in the receiver after heart-lung reimplantation. Histological studies were carried out by biopsy on the heart and on the lung of the donor before removal, at the beginning of the preservation at low temperature, after 3 h of @entity63 in cold, and every hour after recirculation in the @entity616 . Myocardial preservation was conducted with cold cardioplegia at 4 degrees C (Ringer lactate solution with high @entity972 ). Lung preservation was achieved by injecting a @entity7634 -Collins solution at 4 degrees C, with addition of @entity235 plasma, into the pulmonary artery; during the whole ischemic phase, the lung parenchyma was maintained at 0 degrees C, and inflated at a 10 cm @entity2507 pressure. After transplantation, we observed that cardiac output was low in all cases, with normal or subnormal pulmonary arterial pressure. Dynamic lung compliance was very low immediately after transplantation, and increased when restarting the circulation, but deteriorated again after several hours. At the same time alveolo-arterial O2 pressure difference and arterio-alveolar @entity515 pressure difference progressively increased, due to the extensive @entity73 .(ABSTRACT TRUNCATED AT 250 WORDS)
