Immediate functional recovery and avoidance of reperfusion injury with surgical revascularization of short-term XXXX .

@entity1734 @entity2227 @entity235 @entity1563 @entity492 @entity972 @entity855
Functional recovery with surgical revascularization of acutely ischemic myocardium has not been compared with its nonsurgical counterpart in experimental preparations of @entity1563 . This study compares the functional and metabolic recovery of ischemic (1 hr @entity1563 ) segments revascularized either by restoration of coronary patency (simulating nonsurgical recanalization, e.g., angioplasty) or by surgical revascularization with multidose hypothermic @entity972 blood cardioplegic solution. Twenty-two anesthetized open-chest @entity235 were instrumented with Millar micromanometer-tip catheters to measure left ventricular and aortic pressures. Piezoelectric ultrasonic dimension gauges were implanted in the subendocardium supplied by the left anterior descending coronary artery to measure segmental contractile function. In five @entity235 , only biopsy samples were obtained for control measurements of @entity855 , @entity1734 , and tissue water content. In the remaining 17 @entity235 , the left anterior descending artery and collaterals were ligated for 1 hr. The ligatures were removed in eight @entity235 and coronary perfusion continued for 2 hr, simulating nonsurgical reperfusion. The remaining nine @entity235 were placed on cardiopulmonary bypass and the hearts were arrested for 1 hr with multidose (every 20 min) blood cardioplegic solution enhanced with @entity2227 and @entity492 , simulating surgical revascularization (coronary artery bypass grafting). The coronary ligatures were not released until the second cardioplegic infusion, simulating graft placement. One hour of @entity1563 placed 39.4 +/- 2.5% of the left ventricle at risk, and converted active systolic shortening to persistent paradoxical bulging (25.2 +/- 2.2% to -5.8 +/- 1.2% systolic shortening).(ABSTRACT TRUNCATED AT 250 WORDS)
