Characterization of two models of drug-induced constipation in XXXX and evaluation of mustard oil in these models.

@entity3160 @entity1108 @entity19 @entity508 @entity1510 @entity3897 @entity1338 @entity1142 @entity3062
Although it is known that both @entity1338 and @entity3062 cause delayed colonic transit in @entity19 , these models of drug-induced experimental @entity1142 have not yet been fully characterized. Therefore, the aims of this study were to validate the @entity1338 - and @entity3062 -induced delays of colonic transit in @entity19 as models of @entity508 , respectively, and to evaluate the effect of mustard oil, a @entity1108 agonist, in both models. Colonic transit was evaluated in @entity19 by determining the time needed to evacuate a bead inserted into the distal colon. Both @entity3062 and @entity1338 dose-dependently prolonged the evacuation time. @entity1338 (10 microg/kg) and @entity3062 (0.3 mg/kg) tripled the evacuation time compared to controls. These delays were antagonized by the administration of @entity3160 and @entity1510 , respectively. Tegaserod, a gastrointestinal motor-stimulating drug, reversed the delay in both models, but the effects were diminished at high doses. @entity3897 , an antispastic drug, improved the @entity3062 -induced delay, but did not affect the @entity1338 -induced delay. Mustard oil accelerated the colonic transit dose-dependently in both models of drug-induced @entity1142 . These results indicate that @entity1338 - and @entity3062 -induced delays in colonic transit are models of @entity508 , respectively, and that mustard oil may be effective on both types of @entity1142 .
