An experimental study: does the neuroprotective effect increase when XXXX deepens after @entity131 ?

@entity1545 @entity131 @entity932 @entity428 @entity35 @entity2332
BACKGROUND: Experimental approaches have been promising with the use of therapeutic @entity2332 after @entity131 ( @entity131 ) whereas clinical data have not supported its efficacy. OBJECTIVES: This study aimed to investigate whether using selective deeper brain cooling correlates with a more neuroprotective effect on @entity428 ( @entity428 ) increments following @entity131 in @entity35 . MATERIALS AND METHODS: Adult male @entity35 (mean weight = 300 g; n = 25) were subjected to @entity1545 using a modified Marmarou method. Immediately after the onset of @entity131 , @entity35 were randomized into three groups. Selective brain cooling was applied around the head using ice packages. @entity932 ( @entity932 ) and @entity428 were continuously measured at 0, 30, 60, 120, and 180 minutes and recorded for all groups. Group 1 (n = 5) was normothermia and was assigned as the control group. Group 2 (n = 10) received moderate @entity2332 with a target @entity932 of between 32  C - 33  C and Group 3 (n = 10) was given a @entity2332 with a target @entity932 of below 32  C. RESULTS: All subjects reached the target @entity932 by the 30th minute of @entity2332 induction. The @entity932 was significantly different in Group 2 compared to Group 1 only at the 120th minute (P = 0.017), while @entity428 was significantly lower starting from the 30th minute (P = 0.015). The @entity932 was significantly lower in Group 3 compared to Groups 1 and 2 starting from the 30th minute (P = 0.001 and P = 0.003, respectively). The @entity428 was significantly lower in Group 3 compared to Group 1 starting from 30th minute (P = 0.001); however, a significant difference in @entity428 between Group 3 and Group 2 was observed only at the 180th minute (P = 0.047). CONCLUSIONS: Results of this study indicate that selective brain cooling is an effective method of decreasing @entity428 in @entity35 ; however, the @entity2332 caused a greater decrease in @entity428 three hours after @entity2332 induction.
