Natural course of total mismatch and predictors for tissue XXXX .

@entity1 @entity64 @entity4905 @entity1188 @entity432
OBJECTIVE: We longitudinally assessed @entity1 presenting with total mismatch and hypothesized that hypoperfusion intensity ratio (HIR), severity of @entity64 , and @entity432 are predictors of tissue fate. METHODS: @entity1 with suspected @entity64 or @entity4905 admitted to our emergency department between September 2008 and October 2012 with suspected @entity64 or @entity4905 were eligible to participate in the ongoing @entity64 imaging study 1000Plus. @entity1 received acute and follow-up @entity64 MRI, basic demographics were collected, and @entity64 severity was rated according to the NIH @entity64 Scale (NIHSS). Inclusion criteria for the substudy were total mismatch on admission examination and available follow-up. RESULTS: We identified 23 @entity1 with total mismatch: median age 70 years (interquartile range 66-78), 10 female (43.5%). @entity1188 was found on follow-up diffusion-weighted imaging (median lesion size 1.3 mL) in 9 @entity1 (39.1%). @entity1188 was correlated with NIHSS at admission (p = 0.026) and HIR (p = 0.015) but not with @entity432 . Clinical outcome as measured by last recorded NIHSS score and modified Rankin Scale score at discharge was significantly worse in @entity1 with @entity1188 on follow-up. CONCLUSION: Final @entity1188 is frequently seen in @entity1 with total mismatch. Clinical presentation at admission and severity of hypoperfusion measured by HIR, but not occlusion of the supplying vessel, predict tissue fate.
