[Quantitative perfusion imaging by multi-slice CT in @entity64 XXXX ].

@entity1 @entity64 @entity2806 @entity63 @entity93 @entity2541 @entity98 @entity1188
OBJECTIVES: Evaluation of a parametric deconvolution algorithm (DA) in the diagnostic assessment of @entity64 @entity1 by multi- slice spiral computed tomography (MS-CT). MATERIAL AND METHODS: 52 @entity1 (age range 34 - 89 years) with clinically suspected acute @entity63 of one hemisphere and no @entity1188 on plain cerebral CT underwent CT perfusion ( @entity93 ), performed on average 3.4 hours after the onset of symptoms by using MS-CT (4 x 8 mm scan volume). Using a DA-based software module, perfusion images of the cerebral blood perfusion (CBP), cerebral blood volume ( @entity2541 ) and mean transit time ( @entity98 ) were calculated and assessed by two readers for visually apparent perfusion abnormalities. Amount and extension of perfusion disturbances were measured and correlated with the outcome. RESULTS: Of 44 @entity1 , in whom perfusion maps could be generated, territorial @entity1188 was confirmed by follow-up in 22 subjects. With a sensitivity of 95 % @entity63 could be detected on @entity98 -maps (CBP 91 %, @entity2541 77 %). Specificity was highest (100 %) for @entity2541 -maps. @entity1 with @entity1188 showed significant (p < 0.001) reduction of CBP (10.7 vs. 38.3 ml/100 ml/min), @entity2541 (1.3 vs. 2.3 ml/100 ml) and prolongation of @entity98 (12.3 vs. 4.3 s) compared to the contralateral hemisphere, whereas in @entity1 without @entity1188 no significant changes were found. Extension of @entity2541 reduction showed the best correlation (r = 0.82) with final @entity1188 volume. CONCLUSION: The DA-based CTP protocol evaluated in this study is a suitable tool for the early identification and quantification of @entity2806 .
