XXXX @entity1986 in a renal allograft recipient.

@entity1 @entity8 @entity9538 @entity66 @entity8999 @entity1986
@entity1 polyomavirus (PV) @entity1986 has recently been recognized as a cause of severe @entity8 . It occurs in immunosuppressed @entity1 after reactivation of the latent virus PV type BK ( @entity8999 ) in the renal epithelium. @entity66 is defined as a morphologically manifest @entity8 with cytopathic signs accompanied by varying degrees of interstitial inflammatory cell infiltrates and functional impairment. It is also identified by the presence of cells containing viral inclusion bodies (decoy cells) in the urine. The authors report a case of BK PV @entity1986 in a 36-year-old renal allograft recipient. Under light microscopy the chief diagnostic indicator was detection of intranuclear viral inclusions, which were found exclusively in tubular epithelial cells. Cells with viral changes were often enlarged with nuclear atypia and chromatin basophilia. Widespread interstitial plasma cell infiltrates associated with @entity9538 were present. Intranuclear paracrystalline arrays of virus particles 35-38 nm in diameter were present as characteristic ultrastructural indicators. Urine samples revealed decoy cells with ground-glass-type intranuclear inclusions positive for @entity8999 by electron microscopy.
