Comparison of efficacy of intraarticular application of magnesium, XXXX and @entity12802 with placebo in arthroscopic surgery.

@entity1 @entity1340 @entity12802 @entity2400 @entity1343 @entity158 @entity1443 @entity282
PURPOSE: Arthroscopic knee surgery is done in outpatient settings; however, @entity282 is a major barrier for discharge and limits early rehabilitation. The efficacy of intraarticular application of @entity2400 , @entity1343 and @entity12802 , with placebo on @entity282 after arthroscopic meniscectomy was evaluated. METHODS: One hundred and twenty ASA status I-II @entity1 undergoing elective arthroscopic meniscectomy were included in this randomized, single blind, prospective study. Group-M (GM) @entity1 had intraarticular 500 mg of @entity2400 in 20 ml saline; group-P (GP) @entity1 had intraarticular 20 ml saline; group-LB (GLB) @entity1 had 100 mg @entity1343 in 20 ml (0.5%); group-L (GL) @entity1 had intraarticular 8 mg of @entity12802 in 20 ml saline before tourniquet deflation. Postoperative analgesia was maintained by iv @entity1340 PCA 0.3 mg kg(-1) bolus dose and 5 min lockout time during the first 4 h and later with @entity1443 500 mg. The NRS values at rest and at exercise and analgesic consumptions were evaluated at the end of the first, second and 4th hours and at the 12th, 24th and 48th hours by an anaesthesiologist who was blind to the solutions administered. RESULTS: All study groups provided analgesia when compared with GP. The first request of oral analgesic time was shorter in GP. Analgesic consumptions of GP were higher than other groups. @entity158 scores during 1, 2 and 4 h postoperatively were lower in all study groups than the GP. CONCLUSION: Administration of all the drugs provided better analgesia than placebo and the most effective one was @entity12802 .
