Dissociable Effects of @entity750 and XXXX on the Valuation of Harm in Moral Decision Making.

@entity1 @entity3034 @entity146 @entity935 @entity837 @entity1017 @entity750 @entity158 @entity1154
An aversion to harming others is a core component of @entity1 morality and is disturbed in @entity146 . Deficient harm aversion may underlie @entity146 , which both feature in psychopathy. Past work has highlighted monoaminergic influences on aggression, but a mechanistic account of how @entity1154 regulate antisocial motives remains elusive. We previously observed that most @entity1 show a greater aversion to inflicting @entity158 on others than themselves. Here, we investigated whether this hyperaltruistic disposition is susceptible to monoaminergic control. We observed dissociable effects of the @entity750 reuptake inhibitor @entity837 and the @entity935 precursor @entity3034 on decisions to inflict @entity158 on oneself and others for @entity1017 . Computational models of @entity146 showed that @entity837 increased harm aversion for both self and others, while @entity3034 reduced hyperaltruism. The effects of @entity837 were stronger than those of @entity3034 . Crucially, neither drug influenced the physical perception of @entity158 or other components of choice such as motor impulsivity or loss aversion, suggesting a direct and specific influence of @entity750 and @entity935 on the valuation of harm. We also found evidence for dose dependency of these effects. Finally, the drugs had dissociable effects on response times, with @entity837 enhancing behavioral inhibition and @entity3034 reducing slowing related to being responsible for another's fate. These distinct roles of @entity750 and @entity935 in modulating moral behavior have implications for potential treatments of social dysfunction that is a common feature as well as a risk factor for many @entity146 .
