Mono- or polytherapy and the severity of XXXX .

@entity1 @entity410 @entity302 @entity6191 @entity159
1. Out of 295 outpatients who were followed up by our staff for longer than 4 years, a total of 196 @entity1 was subjected to this retrospective study. The inclusion criterion was that they had inevitably been placed on polytherapy of two or more @entity302 ( @entity302 ). In other words, they had failed to reach monotherapy for some reasons. 2. One of the determinant factors for the success or failure of monotherapy was the type of @entity302 . Namely, @entity6191 ( @entity6191 ) was relatively easy to attain by monotherapy regardless of the @entity410 type, whereas @entity6191 ( @entity6191 ) with combined @entity410 and secondary @entity302 (SPE) with mixed @entity410 were not infrequently difficult to be placed on a monotherapy regimen. In the latter case, however, an abrupt withdrawal of @entity302 was apt to cause an exacerbation of @entity410 . 3. There were some @entity1 who could reach a complete freedom from @entity410 as a result of bi- or polytherapy and became socially adaptable and acceptable. They themselves are, if not all, afraid of a possible relapse of @entity410 produced by a reduction in the number of @entity302 hitherto prescribed. In some cases, a family member may refuse monotherapy, or even physicians are reluctant to switch to monotherapy because the @entity1 have experienced @entity159 in the past.(ABSTRACT TRUNCATED AT 250 WORDS)
