Infarct Volume Prediction by Early Magnetic Resonance Imaging in a @entity19 @entity64 Model Depends on XXXX Duration and Time of Imaging.

@entity64 @entity63 @entity2500 @entity19 @entity1188
BACKGROUND AND PURPOSE: Despite standardization of experimental @entity64 models, final @entity1188 sizes after @entity2500 ( @entity2500 ) vary considerably. This introduces uncertainties in the evaluation of drug effects on @entity64 . Magnetic resonance imaging may detect variability of surgically induced @entity63 before treatment and thus improve treatment effect evaluation. METHODS: @entity2500 of 45 and 90 minutes induced brain @entity1188 in 83 @entity19 . During, and 3 and 6 hours after @entity2500 , we performed multiparametric magnetic resonance imaging. We evaluated time courses of cerebral blood flow, apparent diffusion coefficient (ADC), T1, T2, accuracy of @entity1188 prediction strategies, and impact on statistical evaluation of experimental @entity64 studies. RESULTS: ADC decreased during @entity2500 but recovered completely on reperfusion after 45 and partially after 90-minute @entity2500 , followed by a secondary decline. ADC lesion volumes during @entity2500 or at 6 hours after @entity2500 largely determined final @entity1188 volumes for 90 but not for 45 minutes @entity2500 . The majority of chance findings of final @entity1188 volume differences in random group allocations of animals were associated with significant differences in early ADC lesion volumes for 90, but not for 45-minute @entity2500 . CONCLUSIONS: The prediction accuracy of early magnetic resonance imaging for @entity1188 volumes depends on timing of magnetic resonance imaging and @entity2500 duration. Variability of the posterior communicating artery in C57Bl6 @entity19 contributes to differences in prediction accuracy between @entity2500 . Early ADC imaging may be used to reduce errors in the interpretation of post @entity2500 treatment effects on @entity64 volumes.
