Treg/Th17 balance in stable CAD XXXX with different stages of @entity453 .

@entity1 @entity404 @entity951 @entity453 @entity731 @entity688
Objective. Immune processes play a significant role in @entity731 plaque progression. Regulatory T cells and T helpers 17 were shown to possess anti- and pro-atherogenic activity, respectively. We aimed to investigate the balance of circulating Treg and Th17 in stable @entity951 @entity1 with different stages of @entity453 . Methods. Treg, Th17 and Th1 cell frequencies were studied in 117 @entity1 via direct immunofluorescence staining and flow cytometry. Group 1 had intact coronary arteries. Group 2 and Group 3 had undergone previous coronary stenting; in Group 2 no @entity453 was found, in Group 3 @entity1 had disease progression in non-invaded coronary arteries. Group 4 had severe @entity453 . Results. The frequencies of @entity404 +CD25highCD127low, @entity404 +foxp3+, and @entity404 +IL10  +  T cells were decreased, and @entity404 +IL17  +  T cells frequencies were increased in group 4 vs. 1. Treg/Th17 ratios were declined in groups 3 and 4 vs. groups 1 and 2. @entity688 level was lower while hsCRP and sCD25 levels were higher in group 4 vs. 1. Conclusion. We assume that the imbalance in pro- and anti-inflammatory/atherogenic lymphocyte subpopulations is associated with @entity731 progression.
