Primary XXXX of the mediastinum: a clinicopathological report of six cases.

@entity1 @entity632 @entity3726 @entity4619 @entity786 @entity4911 @entity5855 @entity1892 @entity1891 @entity1893 @entity617
BACKGROUND: Primary mediastinal @entity1893 [ @entity1893 ] predominates in young adult with diffuse large B-cell histologic characteristics, and favorable prognosis. Six @entity1 with this disease were diagnosed and treated at the Tri-Service General hospital during the period of 1986 to 1991. METHODS: Pathology data were reviewed. All cases were classified according to the International Working Formulation. All specimens were studied immunohistologic for immunoglobulin kappa and lambda light chains, @entity4619 ( @entity4619 ), B cell marker (L26) and T cell marker ( @entity4911 _ @entity5855 ). All @entity1 were treated with @entity786 , @entity632 , @entity1891 and @entity617 ( @entity3726 ) and adjuvant radiotherapy. RESULTS: Most of the @entity1 were young adults with bulky disease in the anterior mediastinum. All presented with symptoms attributed to a rapidly growing mass. Four @entity1 had superior vena cava syndromes. The histologic types were @entity1892 , including immunoblastic cell in two, and diffuse large cleaved cells in four @entity1 . Three were in stage II and the others were in stage IV. Complete response was achieved in four @entity1 and partial response in two, with an overall response rate of 100%. CONCLUSIONS: The results suggest that primary @entity1893 commonly occurs in young adults and had an associated aggressive clinical course. In view of these results, observation have also suggested that intensive chemotherapy and bone marrow transplantation are needed for @entity1 who relapse or fail to get complete remission.
