XXXX . Clinical presentation, cytologic pattern and stromal changes.

@entity1 @entity1494 @entity5 @entity4 @entity189 @entity150 @entity546 @entity2335
The clinical presentation, cytologic pattern and stromal changes in the cystectomy specimen were studied in a group of 26 @entity1 with @entity150 who underwent cystectomy. Only cases in which the nuclear area of the @entity189 in situ cells was over 80 sq micron (large-cell type) were included in this study. The results indicate that the cells from large-cell @entity150 exfoliate easily, resulting in a cytologic pattern of predominantly single, highly abnormal @entity5 cells. Due to the increased exfoliation of the affected epithelium, the @entity1494 is focally denuded; therefore, while cytology may be strongly positive for @entity5 in these cases, the histologic diagnosis can be falsely negative when only denuded stroma is biopsied. The @entity4 causes complaints of " @entity2335 ." The neoplastic urothelium may involve contiguously related epithelial surfaces. When the lesion extends into the prostatic ducts, the @entity1 can have "pseudoprostatitis" complaints. Urethral extension may give @entity546 . In one female @entity1 , involvement of the vagina and vulva was found. @entity189 in situ may develop in @entity1 with papillary low-grade @entity150 during follow-up, with a concomitant shift in the cytologic and clinical patterns; this deserves the consideration and attention of the cytologist and the clinician due to its serious clinical implications.
