Randomized Comparison of Surveillance Intervals in Familial XXXX .

@entity1 @entity652 @entity6523 @entity14
PURPOSE: Colonoscopic surveillance is recommended for individuals with @entity14 ( @entity14 ). However, the appropriate screening interval has not yet been determined. The aim of this randomized trial was to compare a 3-year with a 6-year screening interval. @entity1 AND METHODS: Individuals between ages 45 and 65 years with one first-degree relative with @entity14 age < 50 years or two first-degree relatives with @entity14 were selected. @entity1 with zero to two @entity652 at baseline were randomly assigned to one of two groups: group A (colonoscopy at 6 years) or group B (colonoscopy at 3 and 6 years). The primary outcome measure was @entity6523 ( @entity6523 ). Risk factors studied included sex, age, type of family history, and baseline endoscopic findings. RESULTS: A total of 528 @entity1 were randomly assigned (group A, n = 262; group B, n = 266). Intention-to-treat analysis showed no significant difference in the proportion of @entity1 with @entity6523 at the first follow-up examination at 6 years in group A (6.9%) versus 3 years in group B (3.5%). Also, the proportion of @entity1 with @entity6523 at the final follow-up examination at 6 years in group A (6.9%) versus 6 years in group B (3.4%) was not significantly different. Only @entity6523 at baseline was a significant predictor for the presence of @entity6523 at first follow-up. After correction for the difference in @entity6523 at baseline, differences between the groups in the rate of @entity6523 at first follow-up and at the final examination were statistically significant. CONCLUSION: In view of the relatively low rate of @entity6523 at 6 years and the absence of @entity14 in group A, we consider a 6-year surveillance interval appropriate. A surveillance interval of 3 years might be considered in @entity1 with @entity6523 and @entity1 with >=  three @entity652 .
