Noninvasive evaluation of renal oxygenation in XXXX by BOLD-MRI.

@entity1 @entity10911 @entity8 @entity6 @entity2316 @entity519 @entity164
PURPOSE: To evaluate the renal oxygenation in @entity164 2 @entity6 by blood oxygenation level dependent magnetic resonance imaging (BOLD-MRI). MATERIALS AND METHODS: Forty-eight @entity1 with @entity164 2 @entity6 and 67 healthy controls were recruited. All @entity1 were further divided into four subgroups based on renal functional level. Bilateral renal cortical R2* ( @entity10911 *) and medullary R2* (MR2*) values were extracted and quantified on BOLD-MRI, then R2* ratio between medulla and cortex (MCR) was calculated. @entity10911 *, MR2* and MCR were compared among the groups separately. The relationships were analyzed between R2* values and clinical index of renal function. RESULTS: Compared with controls, MR2* and @entity10911 * in @entity6 were significantly increased. The positive relationship was found between MR2* and estimated glomerular filtration rate (eGFR), and @entity10911 * was negatively correlated with eGFR. Interestingly, the MCR increased in early stage of @entity6 and decreased along with the aggravation of @entity2316 ( @entity2316 ). CONCLUSION: BOLD-MRI can non-invasively detect and assess the @entity8 in @entity6 . Our findings suggest that @entity519 in medulla is more apparent and earlier than in cortex. During the progression of @entity2316 , a reversion of corticomedullary oxygenation gradient can be detected, thus, MCR would be adopted to suppose the progression and prognosis of @entity2316 .
