Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in XXXX .

@entity1 @entity1164 @entity6 @entity944 @entity4346 @entity453 @entity955 @entity1011 @entity583 @entity943 @entity1002
BACKGROUND: Following @entity583 , individual @entity1 can have wide variations in the extent of @entity1002 ( @entity1002 ) and increased left ventricular (LV) mass. Both affect the risk for @entity1164 , but only LV ejection fraction is used for risk prediction. OBJECTIVE: The purpose of this study was to evaluate the independent as well as the additive contributions of increased LV mass and decreased LV ejection fraction to @entity1164 in the general population. METHODS: In the ongoing Oregon Sudden Unexpected Death Study, we studied consecutive @entity1164 cases (n = 191) and @entity453 controls (n = 203) from the Portland, Oregon, metropolitan area (population approximately 1,000,000; 2002-2008). Comparisons of echocardiographic LV mass obtained prior and unrelated to @entity1164 ( @entity1164 ) were conducted, and a logistic regression model was used to evaluate the relationship between @entity1164 , severe @entity1002 , LV mass, and other relevant clinical variables. RESULTS: In a multivariate model, both severe @entity1002 and @entity4346 ( @entity4346 ) were associated with increased @entity1164 risk (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.1-3.2 for severe @entity1002 ; OR 1.8, 95% CI 1.1-2.9 for @entity4346 ). In @entity1 with coexisting severe @entity1002 and @entity4346 , risk of @entity1164 was additive (OR 3.5, 95% CI 1.7-7.2). In the same model, increased age, @entity955 /flutter, elevated @entity1011 , and @entity6 independently increased risk, and use of angiotensin receptor blockers attenuated risk. CONCLUSION: Reduced LV ejection fraction and increased LV mass had independent and additive effects on risk of @entity944 . Despite the significant overlap between the two conditions, these findings point toward the existence of independent mechanistic pathways for @entity943 that occur due to @entity1002 and @entity4346 .
