XXXX -induced @entity1224 and pathology in the @entity840 .

@entity32 @entity840 @entity16 @entity10345 @entity1544 @entity26678 @entity112 @entity6587 @entity3137 @entity1224
We assessed the nature and progression of @entity3137 and histaminic reactivity in English short-haired @entity840 at 2, 24, 72, 168, and 504 hours after @entity26678 ( @entity10345 ) exposure (4 hours of 3 ppm of TDI for 5 consecutive days). To also determine whether TDI-specific, IgE-like antibodies developed in TDI-exposed animals, passive cutaneous anaphylaxis testing was done 28 days after TDI. Bronchial reactivity was determined serially by measuring specific airway conductance as a function of increasing doses of aerosolized @entity112 in six exposed and three control animals studied intact and unanesthetized. The remaining 10 exposed and 10 control @entity840 were sacrificed in groups of two at each time point to obtain airway tissue for light microscopic examination. We found that @entity1224 to @entity112 occurred after TDI in all animals tested. It was maximal 2 hours after the 5-day exposure and remitted by 72 hours. In addition, marked @entity1224 occurred after TDI that persisted for at least 168 hours. There were dramatic signs of @entity16 associated with the @entity6587 that included substantial decreases in epithelial cilia, mucin content, and mast cells, as well as @entity1544 , numerous mitotic figures, and a prominent polymorphonuclear leukocytic infiltrate. Passive cutaneous anaphylaxis tests in exposed animals were negative. Our results suggest that TDI-induced @entity6587 may be related to @entity3137 and @entity32 .
