Protective effect of XXXX on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings.

@entity1 @entity5721 @entity63 @entity1711 @entity450 @entity1710 @entity5261 @entity468 @entity528 @entity385
BACKGROUND AND PURPOSE: The goal of thrombolytic therapy in @entity1 with acute @entity385 is early recanalization, but this may result in delayed @entity5721 . The purpose of this study was to evaluate the neuroprotective effect of @entity5261 in a transient @entity63 cat model by using MR perfusion imaging and histopathologic analyses. METHOD: One-hour temporary occlusion of the left middle cerebral artery of @entity468 was performed in the control @entity63 group (n = 10), and 100 mg/kg of @entity5261 was intravenously injected immediately after recanalization in the @entity5261 -treated group (n = 15). MR imaging was performed at 1, 24, and 48 hours after recanalization, and the perfusion patterns were investigated. Terminal-deoxynucleotidyl transferase mediated nick and end-labeling (TUNEL) and @entity1710 - @entity1711 (H_E) stainings were performed at the corresponding sections. RESULTS: In the control @entity63 group, the number of TUNEL-positive cells was significantly increased in the areas with reperfusion @entity450 (P < .05). In the @entity5261 -treated group, no significant increase in the number of TUNEL-positive cells was noted in the areas of reperfusion @entity450 . The difference in the number of TUNEL-positive cells between the control @entity63 and @entity5261 -treated group in the areas of reperfusion @entity450 was significant (P < .05). The total number of TUNEL-positive cells and the area of severe @entity63 @entity528 on H_E stain were also significantly attenuated in the @entity5261 -treated @entity468 compared with the control @entity63 @entity468 (P < .05). CONCLUSION: Our results suggest that @entity5261 has neuroprotective effects against @entity5721 and @entity63 .
