Estimating glomerular filtration rate: Performance of the CKD-EPI equation over time in @entity1 with @entity164 2 XXXX .

@entity1 @entity6 @entity1674 @entity740 @entity164 @entity5531 @entity33299 @entity165
AIMS: To assess the performance of the @entity740 Epidemiology Collaboration (CKD-EPI) equation at baseline and longitudinally in @entity1 with @entity164 2 @entity6 . METHODS: Adults with @entity164 2 @entity6 attending Austin Health, Melbourne, with>= 3 prospective @entity33299 measurements were included in this retrospective study. Plasma disappearance rate of @entity5531 ( @entity5531 ) was used to calculate measured @entity33299 ( @entity33299 ) and compared to estimated @entity33299 (eGFR). The agreement between @entity33299 and eGFR was estimated using Intraclass Correlation Coefficient (ICC). RESULTS: 152 @entity1 had a median of 4 (IQR: 3, 5) @entity33299 measurements over a period of 11years (IQR: 9, 12). The difference between @entity33299 and eGFR increased proportionally to the magnitude of the @entity33299 , increasing by 0.2ml/min/1.73m(2) for every 1ml/min/1.73m(2) increase in @entity33299 , indicative of proportional bias. At lower @entity33299 levels, eGFR overestimated @entity33299 , and at higher @entity33299 levels, eGFR underestimated @entity33299 . There was a significant association between LDL @entity165 , @entity1674 , HbA1c, diastolic blood pressure and the difference between @entity33299 and eGFR. CONCLUSIONS: The CKD-EPI formula underestimates @entity33299 and the rate of decline of @entity33299 in @entity1 with @entity164 2 @entity6 with an @entity33299 greater than 60ml/min/1.73m(2). The association between LDL @entity165 , @entity1674 , HbA1c, diastolic blood pressure and the difference between @entity33299 and eGFR warrants further study.
