Association between subclinical carotid atherosclerosis, hyperhomocysteinaemia and XXXX .

@entity1 @entity455 @entity1255 @entity73 @entity5784 @entity731 @entity121
OBJECTIVE: Evidence suggests that @entity121 ( @entity121 ) and plasma @entity1255 ( @entity5784 ) levels are associated with one another, and both appear to be related to @entity73 . However, no connection between both factors taken together and @entity73 ( @entity73 ) has been established. This study analysed potential relationships between @entity121 , @entity5784 and @entity73 . METHODS: We included 105 @entity1 with @entity73 and 76 controls with no history of @entity455 . All @entity1 underwent laboratory analyses, a carotid ultrasound, and clinical and neuropsychological assessment. We used the Mantel-Haenszel test (MHT), ANCOVA and multiple linear regression models (MLRM) to examine any associations between @entity121 , @entity5784 and cognitive state. RESULTS: The MHT revealed a significant association between @entity121 and risk of @entity73 (z = 4.285, P < 0.0001). The OR for the upper quartile vs the lower quartile was 5.12 (95% CI: 2.12-12.36). MHT also showed a clear association between @entity5784 levels and risk of @entity73 (z = 3.01, P = 0.003). OR for the upper vs the lower quartile was 3.39 (95% CI: 1.41-8.12). Additionally, we found a correlation between @entity121 and @entity5784 (r = 0.162, P = 0.032). CONCLUSIONS: Our results suggest that there is a connection between @entity121 , @entity5784 levels and presence of @entity73 in a population with no history of clinically manifest @entity731 . Furthermore, there is also a connection between the @entity121 and @entity5784 levels themselves.
