The significance of intrathecal catheter location in XXXX .

@entity35 @entity3303 @entity132 @entity616
Although chronic intrathecal catheterization is a widely used method in @entity35 , few calibration experiments have been performed. In this study, we investigated the correlation between the side position of the catheter tip and the side differences observed in the motor and @entity132 after intrathecal administration of @entity3303 to a large number of @entity35 . The existence of a @entity616 was determined by the paw withdrawal test. The motor impairment was assessed by observing the complete clubbing of the hindpaw and measuring the hindpaw grip strength. After experimental use, we established the position of the catheter tip. The catheter tips were variously located in all directions of the transverse plane in the @entity35 spinal subarachnoid space. @entity3303 administration (100 or 500 microg/5 microL; n = 264 and 112, respectively) led to dose-dependent motor and @entity132 . The effect of 100 microg of @entity3303 exhibited side differences; i.e., the extents of both motor (r = 0.77) and sensory (r = 0.60 and r = 0.67 for the right and the left side, respectively) disturbances correlated significantly with the location of the catheter tip. Our data have shown that detection of the paralytic and/or antinociceptive effect of small-dose @entity3303 before planned experiments is a simple and reliable method for prediction of the location of the catheter tip. We suggest that the position of the catheter might cause side differences in the drug effect, especially if small doses of drugs are administered and their effects are investigated on both sides.
