Prediction and monitoring of the response to chemoradiotherapy in oral XXXX using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings.

@entity1 @entity3798 @entity5 @entity957 @entity35621
OBJECTIVES: To evaluate whether a pharmacokinetic analysis is useful for both predicting and monitoring the response to chemoradiotherapy (CRT) in @entity5 . METHODS: @entity1 with @entity957 treated with preoperative CRT and surgery were enrolled. They underwent dynamic contrast-enhanced MRI before (n   =   23), and after CRT (n   =   20). We estimated four parameters: arrival time of contrast medium (TA), exchange rate constant from the extracellular extravascular space (EES) to plasma (k(ep)), elimination of contrast medium from the central compartment (k(el)) and an amplitude scaling constant ( @entity3798 ) using the @entity35621 model. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato's classification. We analysed the correlation between the parameters and the histological evaluation. RESULTS: The pre-CRT @entity3798 between the responders and non-responders was significantly different (P   =   0.046), however, the three parameters (TA, K(ep), K(el)) were not significantly different among the groups (P   =   0.76, P   =   0.60, P   =   0.09). As @entity3798 decreased, the @entity5 response improved. The change in the @entity3798 between the pre- and post-CRT of responders was significantly higher than that of non-responders (P   =   0.043). CONCLUSION: The @entity3798 , which is affected by the ratio of the EES, was an important parameter for predicting and monitoring the @entity5 response to CRT.
