@entity32 is associated with decreased functional connectivity within corticostriatal reward circuitry in XXXX .

@entity1 @entity32 @entity650 @entity308 @entity1356 @entity935 @entity73 @entity4270 @entity1193 @entity51 @entity2146 @entity1851
@entity308 is associated with alterations in corticostriatal reward circuitry. One pathophysiological pathway that may drive these changes is @entity32 . Biomarkers of @entity32 (for example, cytokines and @entity1851 are reliably elevated in @entity308 @entity1 . Moreover, administration of inflammatory stimuli reduces neural activity and @entity935 release in reward-related brain regions in association with reduced motivation and @entity4270 . Accordingly, we examined whether @entity32 in @entity308 affects corticostriatal reward circuitry to lead to deficits in motivation and goal-directed motor behavior. Resting-state functional magnetic resonance imaging was conducted on 48 medically stable, unmedicated outpatients with major @entity308 . Whole-brain, voxel-wise functional connectivity was examined as a function of @entity1851 using seeds for subdivisions of the ventral and dorsal striatum associated with motivation and motor control. Increased @entity1851 was associated with decreased connectivity between ventral striatum and ventromedial prefrontal cortex (vmPFC) (corrected P<0.05), which in turn correlated with increased @entity4270 (R=-0.47, P=0.001). Increased @entity1851 similarly predicted decreased dorsal striatal to vmPFC and presupplementary motor area connectivity, which correlated with decreased motor speed (R=0.31 to 0.45, P<0.05) and @entity2146 slowing (R=-0.35, P=0.015). Of note, mediation analyses revealed that these effects of @entity1851 on connectivity mediated significant relationships between @entity1851 and @entity4270 and @entity73 . Finally, connectivity between striatum and vmPFC was associated with increased plasma @entity650 , @entity1356 and @entity1193 (R=-0.33 to -0.36, P<0.05). These findings suggest that decreased corticostriatal connectivity may serve as a target for anti-inflammatory or pro-dopaminergic treatment strategies to improve motivational and @entity51 in @entity1 with @entity32 , including @entity308 .
