Alpha 2-adrenoceptors in amygdala control renal sympathetic nerve activity and renal function in conscious spontaneously @entity101 XXXX .

@entity3160 @entity8 @entity10342 @entity101 @entity1372 @entity35 @entity10341 @entity8074
The contributions of alpha 2- and beta 2-adrenoceptors in the central amygdaloid nucleus to the @entity8 and decreased urinary @entity1372 excretion resulting from environmental stress (air jet) in conscious spontaneously @entity101 @entity35 (SHR) were examined. Air stress increased mean arterial pressure and renal sympathetic nerve activity (47% from 9.3 +/- 0.8 integrator resets/min), and decreased urinary @entity1372 excretion (38% from 2.4 +/- 0.3 microEq/min/100 g b. wt.). After bilateral administration of @entity8074 (2 X 2.5 micrograms) (alpha 2-adrenoceptor agonist) into the central amygdaloid nucleus of the same SHR, air stress had no effect on renal sympathetic nerve activity (+7% from 7.5 +/- 0.8 integrator resets/min) or urinary @entity1372 excretion (+5% from 3.5 +/- 0.4 microEq/min/100 g b. wt.), but still increased mean arterial pressure. These effects of guanabenz were prevented by the prior bilateral administration of the alpha 2-adrenoceptor antagonist, @entity3160 (2 X 15 micrograms), into the central amygdaloid nucleus; @entity3160 alone had no effect on the renal responses to air stress in SHR. Guanabenz in the lateral cerebral ventricle (2 micrograms), the basolateral amygdaloid nucleus (2 X 2.5 micrograms) or a site dorsal to the central amygdaloid nucleus in the area of globus pallidus (2 X 2.5 micrograms) had no effect on the renal sympathetic nerve activity or urinary @entity1372 excretion responses to air stress. Similarly, @entity10342 (2 X 1 microgram; @entity10341 antagonist) in the central amygdaloid nucleus had no effect on the renal responses to air stress.(ABSTRACT TRUNCATED AT 250 WORDS)
