The critical role of @entity650 in the pathogenesis of XXXX .

@entity1 @entity650 @entity455 @entity1711 @entity1252 @entity1198 @entity12040 @entity3646 @entity4155 @entity1710 @entity379 @entity731
OBJECTIVES: To investigate T cell subsets and immune cytokine profiles in untreated @entity12040 ( @entity12040 ) @entity1 and the underlying immunopathological mechanism. METHODS: We enrolled 50 untreated @entity12040 @entity1 and 40 age-matched controls (20 healthy controls, 20 untreated @entity1252 @entity1 ). Enzyme-linked immunosorbent assays (ELISAs) were used to define cytokine profiles in all @entity1 , and flow cytometry was performed for 9 @entity12040 @entity1 and 12 healthy controls. @entity1710 and @entity1711 (H _ E) staining and immunohistochemistry (IHC) were performed in aortic tissues of 9 @entity12040 and 9 @entity731 @entity1 ; clinical data were also collected. RESULTS: Circulating CD4+ T cells were more frequent in @entity12040 @entity1 (p<0.05). Frequencies of @entity1198 , Th2, and Th17 cells were higher, whereas Treg cells were reduced in @entity12040 . Significantly higher levels of @entity650 and lower levels of @entity379 , @entity3646 , and @entity4155 were detected in @entity12040 @entity1 (p<0.05). By H _ E staining, thickened vascular walls with proliferation of collagen fibre were observed in most @entity1 . Inflammatory sites with infiltrating macrophages, lymphocytes, and neutrophils were located in adventitia. IHC revealed T cells (mainly CD4+ T cells) in @entity455 . Additionally, @entity650 was positive throughout the vascular wall in most specimens, whereas @entity379 , IL-12, and @entity4155 were detected in inflammatory sites of active @entity1 . @entity650 levels were positively related to ESR, CRP, and Kerr scores (p<0.05). CONCLUSIONS: Significantly increased levels of @entity650 were detected in peripheral blood and aortic tissues of untreated @entity1 . @entity650 might be a sensitive biomarker to assess disease activity and could be critical in the immunopathogenesis of @entity12040 .
