Spinal nicotinic receptor activity in a genetic model of XXXX .

@entity101 @entity2514 @entity3371 @entity8147 @entity158 @entity35 @entity10446
Intrathecal @entity10446 , a nicotinic receptor agonist, elicits greater dose-dependent increases in blood pressure, heart rate and nociceptive responses in SHR than normotensive @entity35 strains. Similar to adult @entity35 , cardiovascular and nociceptive responses were augmented in prehypertensive SHR than age-matched WKY. While @entity2514 or @entity3371 pretreatment significantly lowered blood pressure in both SHR and WKY @entity35 , responses to i.t. @entity10446 were still greater in SHR. By contrast, i.t. @entity10446 elicited responses were not exaggerated in @entity8147 -salt hypertensive WKY @entity35 . Pressor and irritation responses to i.t. @entity10446 can be divided into a transient, initial and persisting, late phases. Both are augmented in SHR. In F1 @entity35 , only the late phase pressor and @entity158 responses to i.t. @entity10446 are similar in magnitude to those observed in SHR suggesting a possible dominant trait in the SHR. Overall, our findings suggest that hyper-responsiveness in nociception and pressor activity to spinal @entity10446 in SHR may be pathogenetically associated, but not a consequence, of @entity101 .
