Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of @entity1 with XXXX .

@entity1 @entity23944 @entity29088 @entity7501 @entity11225 @entity10094 @entity1468 @entity56203
The objective of this study was to quantify the relative expression of @entity11225 , inhibin/activin beta(A), beta(B), @entity23944 and beta-glycan genes in placental tissue of term pre-eclamptic @entity1 and controls to investigate if these genes are up-regulated in the placenta in @entity1468 . Seven @entity1 with @entity10094 were matched with 10 normal pregnant controls for gestational age, maternal age, and parity. Total RNA was isolated from each sample. Complementary DNA samples produced by reverse transcription were used in the real time PCR to quantify the expression of @entity23944 subunits, follistatin, ACTRIA, @entity56203 , ACTRIIA, @entity29088 , beta-glycan and @entity7501 genes. The ratio between the target and @entity7501 expression was calculated to provide relative gene expression. @entity11225 : @entity7501 and inhibin/activin beta(A): @entity7501 ratios were significantly higher in placental tissue from @entity1 with @entity1468 (P = 0.04 and P = 0.01 respectively) compared with matched control placental gene expression. Placental samples from both groups expressed beta(B), @entity23944 and beta-glycan genes. However, there was no significant difference in the relative expression of these genes between the groups. Increases in the placental expression of @entity11225 and inhibin/activin beta(A) subunit genes could contribute to the rise in circulating levels of @entity11225 and activin A in @entity1468 . The mechanism(s) involved in increased gene expression in @entity1468 is as yet unclear.
