Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal XXXX .

@entity172 @entity1 @entity1372
OBJECTIVE: Controversies surrounding the physiological effects of hormone replacement therapy (HRT) currently lie at the forefront of medicine. Important interindividual factors that affect blood pressure, such as smoking, body mass and @entity1372 intake, may account for the conflicting findings seen in studies examining the effects of HRT on blood pressure. DESIGN: The study was a randomized, double-blind, placebo-controlled trial. METHODS: The effect of combination HRT and @entity172 -only replacement therapy (ERT) on ambulatory blood pressure was examined in a sample of 46 healthy, normotensive, non-smoking, non-obese postmenopausal @entity1 between 45 and 65 years of age. Twenty-four hour urinary @entity1372 excretion was examined prior to and following treatment. The @entity1 were randomized to 3 months' treatment with HRT, ERT or placebo. RESULTS: After treatment, there were no significant effects of either HRT or ERT on daytime or night-time systolic or diastolic blood pressure. @entity1372 excretion was similar across the groups. There were no effects of treatment on night-time blood pressure dipping. CONCLUSIONS: The findings from this prospective treatment study support the conclusion that HRT has no significant effect on daytime or night-time blood pressure in a sample of healthy, non-smoking postmenopausal @entity1 .
