@entity1068 and XXXX interactions in humans: cardiovascular consequences.

@entity11718 @entity167 @entity2072 @entity551 @entity1068
Intranasal @entity2072 ( @entity11718 ) and oral @entity1068 ( @entity167 ) were administered to nine research volunteers during daily experimental sessions. Following the determination of baseline cardiovascular indexes, an @entity167 cocktail (0, 19.4, 38.7, or 58.1 g of @entity167 in lemonade) was consumed over a ten-minute period. @entity2072 (4, 48, 96 mg) was inhaled 25 minutes after the start of @entity167 drinking. Breath samples were collected 50 minutes after the start of @entity167 drinking to estimate blood @entity167 level (BAL). The effect of these doses, alone and in combination, on @entity551 (BP), while resting and while performing a serial acquisition task, were determined. @entity11718 and @entity167 alone significantly increased HR up to 6 bpm without affecting BP. Combining the two highest doses of @entity11718 with the highest BAL increased HR by 20 bpm. During task performance, in the absence of drug, HR was increased up to 5 bpm, and BP was unchanged. Combining the highest @entity11718 dose and BAL with task performance increased HR by 40 bpm. Small increases in BP were also observed under these conditions. These results indicate that combinations of @entity167 , @entity11718 and task performance produce greater increases in HR than BP, and, in addition, this increase in HR is greater than that observed following @entity11718 , @entity167 , or task performance alone.
