Characteristics and Prognostic Factors of XXXX of the Jaws: A Retrospective Cohort Study.

@entity1 @entity66 @entity5 @entity421 @entity1349
Importance: @entity421 of the jaws is rare and clinically distinct from @entity421 of the long bones of the body with different treatment and outcomes. The literature on these @entity5 is limited to case reports and small case series mostly from single institutions. We used data from the population-based national Surveillance, Epidemiology and End Results (SEER) @entity5 registry to determine the epidemiology and prognostic factors associated with @entity421 of the jaws. Objective: To investigate the epidemiologic characteristics and prognostic factors for survival in @entity1 diagnosed with @entity421 of the jaws. Design, Setting, and @entity1 : A retrospective, population-based cohort study of 541 @entity1 in the SEER @entity5 registry diagnosed with @entity421 of the jaws from 1973 through 2011 were reviewed. Exposures: @entity1 had been treated with surgery, radiation, both, or neither. Main Outcomes and Measures: Overall and @entity66 . Results: A total of 541 @entity1 diagnosed with @entity421 of the jaws were identified (49.9% male and 50.1% female, with a mean age of 41.3 years). Kaplan-Meier analysis demonstrated an @entity1349 ( @entity1349 ) and @entity66 ( @entity66 ) of 53% and 62%, respectively, at 5 years and 35% and 54%, respectively, at 10 years. Multivariate Cox regression analysis revealed that independent predictors of @entity1349 and @entity66 included age at diagnosis (hazard ratio [HR], 1.03; 95% CI, 1.02-1.04 [P   <   .001] for @entity1349 ; and HR, 1.03; 95% CI, 1.02-1.05 [P   <   .001] for @entity66 ); stage at presentation (HR, 1.37; 95% CI, 1.10-1.71 [P   =   .006] for @entity1349 ; and HR, 1.34; 95% CI, 1.01-1.76 [P   =   .04] for @entity66 ); and surgical resection (HR, 0.31; 95% CI, 0.16-0.60 [P   <   .001] for @entity1349 ; and HR, 0.22; 95% CI, 0.09-0.56 [P   =   .001] for @entity66 ). @entity5 size was not significant for @entity1349 (HR, 1.00; 95% CI, 1.00-1.01 [P   =   .11] but significant for @entity66 (HR, 1.01; 95% CI, 1.00-1.01 [P   =   .003]). Conclusions and Relevance: To our knowledge, this is the largest study to date investigating prognostic factors for survival in @entity1 diagnosed with @entity421 of the jaws. Determinants of survival include age at diagnosis, stage at presentation, @entity5 size, and surgical therapy. Radiation therapy was not associated with improved survival, reflecting the controversy surrounding its use in in clinical literature.
