The role of @entity3645 in reducing the metabolic complications of XXXX after bariatric surgery: a systematic review.

@entity1 @entity7902 @entity14646 @entity6 @entity28 @entity4961 @entity3645 @entity105 @entity413 @entity165
BACKGROUND: Bariatric surgery is currently the most efficacious treatment for @entity28 and its associated metabolic co-morbidities, such as @entity6 . The metabolic improvements occur through both weight-dependent and weight-independent mechanisms. @entity3645 ( @entity7902 ) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery. This systematic review assesses the evidence from both @entity1 and animal studies for the role of @entity7902 in reducing the metabolic complications of @entity28 following bariatric surgery. METHODS: We conducted a systematic search of Medline and Embase databases to identify all articles investigating the role of @entity7902 in mediating the metabolic changes observed following bariatric surgery in both animal and @entity1 studies. Boolean logic was used with relevant search terms, including the following MeSH terms: ' @entity3645 and salts', 'bariatric surgery', 'metabolic surgery', 'gastrointestinal tract/surgery' and ' @entity28 /surgery'. RESULTS: Following database searches (n=1197), inclusion from bibliography searches (n=2) and de-duplication (n=197), 1002 search results were returned. Of these, 132 articles were selected for full-text review, of which 38 articles were deemed relevant and included in the review. The findings support the effects of @entity7902 on satiety, lipid and @entity165 metabolism, incretins and @entity413 homoeostasis, energy metabolism, gut microbiota and endoplasmic reticulum stress following bariatric surgery. Many of these metabolic effects are modulated through the BA receptors @entity4961 and @entity14646 . We also explore a possible link between @entity7902 and @entity105 following bariatric surgery. CONCLUSIONS: Overall there is good evidence to support the role of @entity7902 in the metabolic effects of bariatric surgery through the above mechanisms. @entity7902 could serve as a novel therapeutic pharmacological target for the treatment of @entity28 and its associated co-morbidities.
