@entity1494 after spinal contusion injury in the adult XXXX .

@entity1 @entity32 @entity35 @entity1494 @entity1566 @entity811 @entity2335
Traumatic @entity1566 ( @entity1566 ) permanently alters bladder function in @entity1 . @entity811 and @entity2335 occur in both @entity1 @entity1566 as well as in rodent models of @entity1566 . Others have reported early @entity1566 -dependent disruption to bladder uroepithelial integrity that results in increased permeability to urine and urine-borne substances. This can result in @entity2335 , or @entity32 of the bladder, an ongoing pathological condition present throughout the chronic phase of @entity1566 in @entity1 . The goals of our study were twofold: (1) to begin to examine the inflammatory and molecular changes that occur within the bladder uroepithelium using a clinically-relevant spinal contusion model of injury, and (2) to assess whether these alterations continue into the chronic phase of @entity1566 . @entity35 received either moderate @entity1566 or sham surgery. Urine was collected from @entity1566 and sham subjects over 7 days or at 7 months to assess levels of excreted proteins. @entity32 in the bladder wall was assessed via biochemical and immunohistochemical methods. Bladder tight junction proteins, mediators of uroepithelial integrity, were also measured in both the acute and chronic phases of @entity1566 . Urine protein and hemoglobin levels rapidly increase following @entity1566 . An @entity1566 -dependent elevation in numbers of neutrophils within the bladder wall peaked at 48 h. Bladder tight junction proteins demonstrate a rapid but transient decrease as early as 2 h post- @entity1566 . Surprisingly, elevated levels of urine proteins and significant @entity1494 proteins could be detected in chronic @entity1566 , suggesting that early pathological changes to the bladder may continue throughout the chronic phase of injury.
