[Correlation of chromosome 1p and 19q status and expression of XXXX mutant @entity818 protein in @entity5 ].

@entity5 @entity818 @entity816 @entity28485 @entity3271
OBJECTIVE: To correlate the presence of chromosome 1p/19q deletion with the expression of @entity28485 mutant @entity818 status in @entity5 , and to explore molecular markers for predicting @entity5 . METHODS: The study included 75 @entity5 (38 @entity3271 and 37 @entity816 ). Immunohistochemistry was used to detect the expression of @entity28485 mutant @entity818 protein, and fluorescence in situ hybridization (FISH) was employed to detect 1p/19q deletion. RESULTS: Deletion of chromosome 1p and/or 19q was detected in 37 cases (37/75, 49.3%), among which co-deletion of 1p and 19q was seen in 34 cases (closely correlated, P < 0.01). @entity3271 WHOIIhad a slightly higher deletion rate than @entity3271 WHO III, although without statistical significance. @entity3271 had a significantly higher deletion rate of chromosome 1p/19q than @entity816 WHO II and WHO III (P < 0.05). While combined loss of 1p/19q was always detected in @entity3271 when FISH was positive, isolated 1p or 19q deletion was only found in @entity816 . The expression of @entity28485 mutant @entity818 was detected in 51 of 75 cases (68.0%), in which @entity3271 had a higher positive rate than @entity816 . Statistical analysis demonstrated a significant correlation between the expression of @entity28485 mutant @entity818 protein and the presence of combined 1p/19q deletion in @entity3271 (P < 0.05). CONCLUSIONS: A significant correlation was observed between the expression of @entity28485 mutant protein and 1p/19q LOH.Expression of 132H mutant @entity818 protein is the potential biomarker for predicating the presence of 1p/19q deletion in @entity3271 .
