Usefulness of oral XXXX in the treatment of @entity3332 after endoscopic submucosal dissection for superficial @entity1721 .

@entity1 @entity3332 @entity5 @entity384 @entity1721 @entity1282 @entity617
BACKGROUND: Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial @entity1721 . However, postprocedure stricture is common after ESD for extensive @entity5 , and multiple @entity384 ( @entity384 ) is required for recalcitrant cases. OBJECTIVE: To evaluate the effectiveness of oral @entity617 in controlling postprocedure @entity3332 . DESIGN: Retrospective study. SETTING: Endoscopy department at a university hospital. @entity1 : @entity1 who underwent complete circular or semicircular ESD for @entity1721 involving more than three fourths of the lumen were treated with either pre-emptive @entity384 or oral @entity617 . INTERVENTION: Preemptive @entity384 was started on the third day post-ESD and continued twice weekly for 8 weeks. Oral @entity617 was started at 30 mg/day on the third day post-ESD , tapered gradually, and then discontinued 8 weeks later. An additional @entity384 was performed on demand in both groups whenever @entity1282 appeared. MAIN OUTCOME MEASUREMENT: The incidence of @entity3332 and number of @entity384 sessions required to relieve @entity1282 . RESULTS: Stricture at 3 months after ESD was found in 7 of 22 @entity1 in the preemptive @entity384 group but only 1 of 19 in the oral @entity617 group (P < .05). The average number of @entity384 sessions required was 15.6 in the preemptive @entity384 group and 1.7 in the oral @entity617 group (P < .0001). After complete circular ESD, 32.7 @entity384 sessions were needed on average in the preemptive @entity384 group, whereas fewer were needed in the oral @entity617 group (P < .05). LIMITATIONS: Nonrandomized study. CONCLUSIONS: Post-ESD esophageal strictures were persistent even if treated preemptively with multiple @entity384 sessions, but oral @entity617 may offer a useful preventive option.
