Clinical evaluation of the efficacy of Shvitrahara kashaya and lepa in XXXX .

@entity1 @entity1694 @entity2118 @entity272 @entity62
Vitiligo is a progressive, idiopathic, @entity2118 of the skin, characterized by @entity62 . PUVA therapy is the treatment of choice in the modern system of medicine. In Ayurveda, Shvitra or Kilasa is the term employed to @entity272 . Shvitra is caused by various dietic and behavioral factors which aggravate the tridoshas, especially the Kapha dosha vitiating the Meda dhatu. Many Ayurvedic drugs are well known for the regeneration of melanocytes, among which Bakuchi is one. The present study was planned to study its efficacy in the regeneration of melanocytes. The outcome of treatment in 50 cases of Shvitra vis-  -vis @entity1694 receiving Shvitrahara kashaya and Shvitrahara lepa was analyzed and compared. Group I (n = 25) @entity1 were treated with Shvitrahara kashaya and Shvitrahara lepa; Group II (n = 15) @entity1 received Shvitrahara lepa only; and the remaining 10 @entity1 of Group III used both (Western medicine) oral psoralens and UV-A therapy. Assessment was done after 6 months with bi-monthly follow-ups. Out of 25 cases in Group I, 17 showed 80% improvement (t = 7.65; P < 0.01) in the surface area, number of lesions, pigmentation and associated symptoms like itching; out of 15 @entity1 in Group II, 10 showed partial repigmentation, i.e. 50% (t = 5.72; P < 0.01) response was observed. In Group III, 90% response (t = 6.14; P < 0.001) in repigmentation and number of lesions as well was noted but eight @entity1 developed adverse effects like sunburn, severe itching and gastric upset on taking oral psoralen. On the basis of results and observations, it can be concluded that Ayurvedic formulation containing Bakuchi is efficacious and has no untoward effects when compared to oral psoralens and UV-A therapy.
