Reducing Sitting Time After XXXX : A Phase II Safety and Feasibility Randomized Controlled Trial.

@entity1 @entity64 @entity508 @entity158 @entity460
OBJECTIVE: To test the safety, feasibility, and effectiveness of reducing sitting time in @entity64 survivors. DESIGN: Randomized controlled trial with attention-matched controls and blinded assessments. SETTING: Community. @entity1 : @entity64 survivors (N=35; 22 @entity1 ; mean age, 66.9  12.7y). INTERVENTIONS: Four counseling sessions over 7 weeks with a message of sit less and move more (intervention group) or @entity460 for bone health (attention-matched control group). MAIN OUTCOME MEASURES: Measures included safety (adverse events, increases in @entity158 , @entity508 , or fatigue) and feasibility (adherence to trial protocol). Secondary measures included time spent sitting (including in prolonged bouts >= 30min), standing, and stepping as measured by the thigh-worn inclinometer (7d, 24h/d protocol) and time spent in physical activity of at least moderate intensity as measured by a triaxial accelerometer. The Multimedia Activity Recall for @entity1 and Adults was used to describe changes in use of time. RESULTS: Thirty-three @entity1 completed the full protocol. Four @entity1 reported falls during the intervention period with no other adverse events. From a baseline average of 640.7  99.6min/d, daily sitting time reduced on average by 30  50.6min/d (95% confidence interval [CI], 5.8-54.6) in the intervention group and 40.4  92.5min/d in the control group (95% CI, 13.0-93.8). @entity1 in both groups also reduced their time spent in prolonged sitting bouts (>= 30min) and increased time spent standing and stepping. CONCLUSIONS: Our protocol was both safe and feasible. @entity1 in both groups spent less time sitting and more time standing and stepping postintervention, but outcomes were not superior for intervention @entity1 . Attention matching is desirable in clinical trials and may have contributed to the positive outcomes for control @entity1 .
