Circulating levels of both Th1 and Th2 chemokines are elevated in XXXX with @entity370 .

@entity1 @entity14420 @entity16952 @entity371 @entity370 @entity366
BACKGROUND: In @entity370 , the T helper type 1 (Th1) response tends to predominate at affected disease sites; however, whether Th1/Th2 polarization occurs in the peripheral circulation is unknown. METHODS: Fifty-two @entity1 with @entity370 and 21 healthy volunteers were investigated. The concentrations of @entity371 ( @entity371 )/ @entity371 and @entity14420 ( @entity14420 )/ @entity14420 in the serum, bronchoalveolar lavage fluid (BALF) and culture supernatant were measured by an enzyme-linked immunosorbent assay. The circulating @entity366 + CD4+ T cells and @entity16952 + CD4+ T cells were assessed by flow cytometry. RESULTS: The @entity366 - or @entity16952 -positive ratios among CD4+ T cells were both higher in @entity370 than in healthy volunteers. The serum levels of both @entity371 and @entity14420 of the @entity1 with @entity370 were significantly higher than those of the healthy volunteers. In @entity1 with @entity370 , a larger amount of @entity371 was generated by the BALF cells, whereas @entity371 production by peripheral blood mononuclear cells did not increase in comparison to the control subjects. The @entity14420 levels produced by peripheral blood mononuclear cells of @entity370 @entity1 were significantly higher than those of the controls, while no difference existed between the 2 groups regarding @entity14420 production by BALF cells. CONCLUSION: @entity371 is mainly produced at the lung and @entity14420 in the peripheral circulation in @entity370 @entity1 . Both @entity371 and @entity14420 cooperatively play a role in the pathogenesis of @entity370 .
