Study of restorative processes in @entity131 in the first seven days after XXXX .

@entity1 @entity1545 @entity131 @entity146 @entity51 @entity204
UNASSIGNED: @entity131 represent the main cause of @entity204 and invalidity all over the world. @entity1 surviving a severe @entity131 often present long-term disabilities, @entity51 , cognitive, @entity146 . @entity1545 are directly caused by the traumatic agent, and indirectly caused by the action of cells involved in the restorative process. The main cells involved in the restorative process are microglias and astrocytes. By using an experimental model, we investigated the reaction of these cells in the first week after a severe @entity1545 , followed by @entity131 . Of the two cell types, the most rapid and intense reaction was held by the macroglias, also known as resident macrophages of the central nervous system. Alongside the activation of local microglias, in the restorative process there were also involved blood monocytes that turned into macrophages. 24 hours after the injury, the number of macrophage cells  mm   at brain wound level increased 2-4 times, after three days - 10-12 times, and after seven days - over 20 times. The astrocyte reaction was slower, their activation being signaled no sooner than three days from injury, when their number in the perilesional brain parenchyma increased approximately two times, while after seven days - approximately 4-5 times. Both astrocytes and macrophages (microglias), besides their beneficial effects in restoring traumatic @entity1545 , may have unfavorable effects upon the nervous cells in the immediate proximity of the injury. Destruction of vascular network by the traumatic agent, and the extremely slow restore of vascularization, partially explain brain neurons @entity204 on extend areas.
