CT findings of XXXX with clinically complete response following neoadjuvant chemotherapy--histological correlation.

@entity1 @entity0 @entity66 @entity5 @entity2286 @entity11595
In @entity0 @entity1 , several regimens of neoadjuvant chemotherapy have been developed in order to achieve prognostic advantages for individual @entity1 . Though some percentages of @entity0 @entity1 show clinically complete response to neoadjuvant chemotherapy, the histopathological specimens of these @entity1 demonstrate a considerably high frequency of the existence of @entity66 . In this study, we aimed to evaluate the therapeutic effect of neoadjuvant chemotherapy for @entity0 @entity1 showing clinically complete response (cCR) to neoadjuvant chemotherapy, using thin-section (5 mm) helical CT (prone position) with bolus injection of contrast agent. Between April 1994 and March 2002, 9 @entity1 with @entity0 showing cCR to the neoadjuvant chemotherapy, who had undergone thin-section CT study both before and following neoadjuvant chemotherapy, enrolled in the study. The mean age of the @entity1 was 46.2 years and all of them were female. The clinical stages were, 8 @entity1 in stage II, and one in stage IIIA. In the CT evaluation, @entity66 was visualized in 5 out of the 9 @entity1 . Histopathological examination disclosed the existence of @entity5 in 6 out of the 9 @entity1 , but only non-invasive @entity5 was revealed in 1 out of the 6. As @entity1 having @entity66 composed only of non-invasive @entity5 are classified into the pathologically complete response group according to the WHO classification, 4 out of these 9 @entity1 showing clinically complete response to the neoadjuvant chemotherapy were classified into pCR (pathologically complete response) group, and another 5 were classified into the @entity11595 (pathologically partial response) group. As a result, the diagnostic accuracy of the second CT study performed after neoadjuvant chemotherapy was evaluated as 77.8%, with a sensitivity of 80.0%, a specificity of 75.0%, a positive predictive value ( @entity2286 ) of 80.0%, and a negative predictive value (NPV) of 75.0%. Therefore, for precise evaluation of the neoadjuvant chemotherapeutic effect for @entity0 , thin-section CT studies are considered to be essential.
