Peripheral blood stem cell collection in a XXXX with @entity1860 and a high circulating nucleated red cell fraction.

@entity1503 @entity1 @entity9236 @entity1860
A high level of circulating @entity1503 ( @entity1503 ) in @entity1 with @entity9236 could potentially complicate peripheral blood stem cell (PSC) collection. The mononuclear @entity1503 might comprise a significant fraction of the total mononuclear cells in the final product. We report a successful PSC collection in a @entity1 with more @entity1503 than WBC in the peripheral blood. A 27-year-old @entity1 with @entity1860 underwent eight PSC collection procedures, seven using the Cobe Spectra (Spectra) and one using the Fenwal CS3000 Plus (CS). PSC product manipulations to remove @entity1503 were unnecessary. As assessed by post-collection @entity1503 : WBC ratio as a percent of the initial ratio, Spectra selectively harvested mononuclear leukocytes over @entity1503 . The collected products had a mean @entity1503 : WBC ratio that was 3.4% of the peripheral blood ratio. Adequate numbers of mononuclear leukocytes were collected with less than 6% @entity1503 contamination. The single CS procedure resulted in a comparable @entity1503 reduction efficiency as the Spectra. We conclude that PSC harvest using automated blood cell separators from @entity1 with a high level of circulating @entity1503 may result in a product with an acceptable number of @entity1503 .
