@entity1255 and lipid peroxidation in haemodialysis: role of @entity4181 and XXXX .

@entity1 @entity4181 @entity66 @entity270 @entity1865 @entity1255 @entity2033 @entity1234 @entity920 @entity731 @entity204 @entity65
BACKGROUND: @entity65 are the leading cause of @entity204 in haemodialysis @entity1 . Hyperhomocysteinaemia is an independent risk factor. Basic research has provided strong evidence that oxidation of low-density lipoprotein (LDL) plays an important role in the pathogenesis of @entity731 . @entity66 , lipid metabolism alterations, and hyperhomocysteinaemia observed in haemodialysis @entity1 could induce increases in LDL oxidation. This study was designed to determine the effect of @entity4181 on hyperhomocysteinaemia and to assess the antioxidant efficacy of @entity4181 . The antioxidant effect of @entity4181 was compared with that of @entity270 . METHODS: Sixteen stable @entity1 (11 @entity1 , five @entity1 ; mean age 54.3+/-6.32 years) on standard haemodialysis received 400 mg of @entity270 , orally, at the end of each haemodialysis session for 3 months. After a 1-month wash-out, they received 10 mg of @entity4181 , intravenously, at the end of each haemodialysis session for an additional 3 months. Blood samples were drawn in the morning after an overnight fast and before dialysis. Plasma @entity270 was analysed by high-pressure liquid chromatography. @entity1234 ( @entity1865 ) was determined using a fluorimetric method and plasma @entity920 oxidized anti-LDL antibodies (Ab-LDLox) were measured with an ELISA method using native LDL and oxLDL as antigens. Plasma @entity1255 was determined by an FPIA method. RESULTS: @entity4181 supplements significantly reduced hyperhomocysteinaemia (-44%), @entity1865 concentrations (-40%), and IgG-LDLox titres (-13%). CONCLUSIONS: Treatment with @entity4181 lowers plasma @entity1255 levels and, like @entity270 , affords antioxidant protection, which prevents lipid peroxidation. This lowering of lipid peroxidation may reduce the risk of @entity731 and prevent or delay @entity65 in @entity2033 @entity1 .
