Left atrial booster pump function is an independent predictor of subsequent life-threatening XXXX in non-ischaemic cardiomyopathy.

@entity1 @entity998 @entity714 @entity384 @entity737 @entity6475 @entity591 @entity299 @entity943 @entity1002 @entity1480
AIMS: Left atrial (LA) function helps to preserve @entity998 and to control pulmonary capillary wedge pressure in the setting of left ventricular (LV) impairment, but little is known about the contribution of the LA function to @entity943 . We sought whether LA booster pump function was associated with @entity943 in @entity1 undergoing primary prevention @entity737 ( @entity737 ) implantation for @entity384 ( @entity384 ), independent of @entity6475 ( @entity6475 ) and @entity1480 ( @entity1480 ). METHODS AND RESULTS: We identified 124 @entity384 @entity1 (56    13, 67 male) who underwent echocardiography pre- @entity737 implantation for primary prevention. The main outcome measure was appropriate @entity737 therapy (anti- @entity591 pacing or shock). The mitral A-wave was used as an LA functional marker. @entity1480 was defined as standard deviation of time to peak strain of each segment. Over a median follow-up of 3.8    2.2 years, 36 @entity1 had appropriate @entity737 therapy, including 23 shocks. @entity1 with appropriate @entity737 therapy had lower A-wave velocity (P < 0.001), larger LA volume (P < 0.001), and impaired circumferential @entity1480 (P = 0.006), but similar ejection fraction (EF) (P = 0.40) and @entity6475 (P = 0.11). In sequential Cox proportional hazards models, A-wave, E/A ratio, and @entity6475 were significantly associated with outcomes, independent of age, sex, and @entity299 or @entity714 . In nested Cox models, mitral A-wave had a prognostic value @entity1002 (E/A, E/e', and LA volume) and @entity1480 . CONCLUSION: LA booster pump function was an independent and incremental predictor of @entity943 in @entity384 over @entity6475 and @entity1480 , and may aid better risk stratification in this population.
