Local delivery of antibiotics via an implantable pump in the treatment of XXXX .

@entity1 @entity2167 @entity4034 @entity4509 @entity5153 @entity1011
Twenty-one @entity1 with @entity4034 were treated with surgical debridement and local antibiotic therapy. @entity4509 (19 @entity1 ) or @entity5153 (2 @entity1 ) was delivered locally via a pump implanted subcutaneously. The outflow catheters were led from the pump subcutaneously to the infected area and placed in the defect created by the surgical debridement. The pump was refilled at intervals, on an outpatient basis. The pump was surgically removed at the conclusion of therapy. Follow-up evaluation was for 12-27 months. The duration of hospitalization was five to 52 days (mean, 23 days). The infusions were sustained for 32-140 days (mean, 63 days). Systemic levels of antibiotics were always below acceptable trough levels. Levels in the wound drainage of the 11 @entity1 who drained after operation were always greater than the upper limit of the assay. Nephrotoxicity and @entity2167 were determined using pre- and posttherapy @entity1011 clearances and audiograms. Two @entity1 exhibited minimal nephrotoxicity ( @entity1011 clearance of 66 ml/minute and 55 ml/minute; normal, 70 ml/minute). There were no other adverse effects of the antibiotics. Sixteen @entity1 have not drained since removal of the pumps.
