Implied functional crossed cerebello-cerebral diaschisis and interhemispheric compensation during hand grasping more than 20  years after XXXX in early childhood.

@entity1 @entity5 @entity895 @entity76 @entity6447 @entity2055
BACKGROUND: Crossed cerebello-cerebral diaschisis (CCCD) conventionally refers to decreased resting cerebral activity caused by injury to the contralateral cerebellum. We investigated whether functional activation of a contralesional cerebral cortical region controlling a specific task is reduced during task performance in a @entity1 with a @entity76 . We also examined functional compensation by the corresponding ipsilesional cerebral cortex. It was hypothesized that dysfunction of the primary sensorimotor cortex ( @entity895 ) contralateral to the @entity76 would be detected together with a compensatory increase in neural activity of the ipsilesional @entity895 . To test these possibilities, we conducted non-invasive functional neuroimaging techniques for bilateral @entity895 during hand grasping, a task known to activate predominantly the @entity895 contralateral to the grasping hand. Activity in @entity895 during hand grasping was measured electrophysiologically by magnetoencephalography and hemodynamically by near-infrared spectroscopy in an adult with mild @entity6447 associated with a large injury of the right cerebellum due to resection of a @entity5 in early childhood. RESULTS: During left hand grasping, increased neural activity was detected predominantly in the right @entity895 , the typical developmental pattern. In contrast, neural activity increased in the bilateral @entity895 with slight right-side dominance during right (ataxic) hand grasping. CONCLUSIONS: This study reported a case that implied functional CCCD and compensatory neural activity in the @entity895 during performance of a simple hand motor task in an adult with @entity76 and mild hemiataxia 24  years prior to the study without rehabilitative interventions. This suggests that @entity76 in early childhood may result in persistent functional abnormalities in the cerebrum into adulthood. Therapeutic treatments that target functional CCCD and interhemispheric compensation might be effective for treating @entity2055 due to @entity76 .
