Association between circulating @entity14257 levels and medication use in XXXX scheduled for cardiac surgery.

@entity1 @entity2661 @entity14257 @entity560
BACKGROUND AND AIM: Low @entity560 status, i.e. circulating @entity14257 (25OHD) levels <50  nmol/l, is independently associated with increased CVD risk. Medication use may influence 25OHD levels. We therefore investigated the association of circulating 25OHD with medication use in @entity1 scheduled for cardiac surgery. METHODS AND RESULTS: A total of 11,256 @entity1 were included in this cross-sectional study. We compared 25OHD levels of medication users (18 groups of continuously used and 5 groups of intermittently used medications) with levels of non-users. Moreover, we assessed variables (medications, demographic and clinical parameters) that were independently associated with 25OHD levels <50  nmol/l. The prevalence of 25OHD levels <50  nmol/l was 65.7%. The use of statins and immunosuppressive agents was significantly associated with higher 25OHD levels and lower odds ratios of 25OHD levels <50  nmol/l. The use of ACE-inhibitors, @entity2661 and antibiotics was associated with lower 25OHD levels and higher odds ratios of 25OHD levels <50  nmol/l. However, only use of antibiotics, immunosuppressive agents and @entity2661 showed clinically relevant differences in 25OHD levels, i.e. differences of more than +4  nmol/l or -4  nmol/l, compared with respective non-users. These medications were prescribed either intermittently (antibiotics, @entity2661 ) and/or infrequently (<2%; immunosuppressive agents, @entity2661 ) and/or its causal relationship with circulating 25OHD is questionable (antibiotics). Female sex and blood drawing during wintertime were associated with the highest odds ratios of 25OHD levels <50  nmol/l. CONCLUSION: Data indicate that in @entity1 with high cardiovascular risk profile medication use does not substantially contribute to 25OHD levels <50  nmol/l.
