Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and @entity28 XXXX .

@entity1 @entity650 @entity28 @entity2690 @entity1386 @entity2842 @entity21320 @entity413
PURPOSE: Most of what we know about adipose tissue is restricted to observations derived after an overnight fast. However, @entity1 spend the majority of waking hours in a postprandial (fed) state, and it is unclear whether increasing @entity1386 impacts adipose tissue responses to feeding. The aim of this research was to investigate postprandial responses in adipose tissue across varying degrees of @entity1386 . METHODS: Thirty males aged 35-55  years with waist circumference 81-118  cm were divided equally into groups categorized as either lean, overweight or @entity28 . @entity1 consumed a meal and insulinaemic, glycaemic and lipidaemic responses were monitored over 6  h. Subcutaneous adipose tissue samples were obtained at baseline and after 6  h to examine changes in gene expression and adipose tissue secretion of various adipokines. RESULTS: Following consumption of the meal, @entity2690 and @entity413 responses were higher with increased @entity1386 (total AUC effects of group; p  =  0.058 and p  =  0.027, respectively). At 6  h, significant time effects reflected increases in @entity650 (F  =  14.7, p  =  0.001) and @entity2842 (F  =  10.7, p  =  0.003) and reduction in @entity21320 adipose tissue gene expression (F  =  24.6, p  <  0.001), all independent of @entity1386 . Ex vivo adipokine secretion from adipose tissue explants remained largely unchanged after feeding. CONCLUSIONS: Increased systemic measures of postprandial metabolism with greater @entity1386 do not translate into increased inflammatory responses within adipose tissue. Instead, postprandial adipose tissue changes may represent a normal response to feeding or a (relatively) normalized response with increased @entity1386 due to either similar net exposure (i.e. per g of adipose) or reduced adipose tissue responsiveness.
