Immune system and prognosis in XXXX : a detailed immunohistochemical analysis.

@entity1 @entity6756 @entity404 @entity2940 @entity1529 @entity1530 @entity5 @entity4755 @entity14 @entity405
The efficacy of @entity5 cell-immune cell interactions depends on a number of factors, for example, the expression of HLA-I on @entity5 cells, the type of immune cell, the accessibility of @entity5 cells for immune cells and the expression of immunogenic epitopes. We assessed infiltration of @entity404 +, @entity405 +, @entity2940 + and @entity4755 + cells in the @entity5 epithelium, @entity5 stroma and advancing @entity5 margin of 93 @entity14 and correlated this to clinicopathological parameters, the expression of @entity1529 and @entity1530 /C on @entity5 cells, the presence of a basal membrane (BM)-like structure surrounding @entity5 nodules and the presence of microsatellite instability/mutator phenotype (absent @entity6756 expression). The median intraepithelial @entity404 +, @entity405 +, @entity2940 + and @entity4755 + cell infiltrations were 3, 23, 0 and 0 cells/mm(2) @entity5 , respectively. @entity1529 /BC expression by @entity5 cells was normal in 28/43%, heterogeneous in 59/48% and absent in 13/9% of the cases. A BM-like structure surrounding the @entity5 nodules was absent, present and thick in 47, 38 and 15% of the cases. Six cases lost @entity6756 expression. There was a positive correlation between leukocyte infiltration in the three compartments for @entity404 +, @entity405 +, @entity2940 + (partly) and @entity4755 + (all P<0.05) cell infiltration. Intraepithelial @entity405 + cell infiltration inversely correlated with @entity1529 (P=0.04) and @entity1530 /C expression (P=0.04). Intraepithelial @entity4755 + cell infiltration inversely correlated with @entity1530 /C expression (P=0.04). Moreover, intraepithelial infiltration of @entity405 + and @entity4755 + cells was inversely correlated to the presence of a BM-like structure (P=0.003 and 0.04, respectively). Uni- and multivariate analyses showed that a lower @entity5 stage (P=0.004) and marked infiltration of @entity405 + (P=0.04) and @entity4755 + cells (P=0.05) at the advancing @entity5 margin were independent prognostic factors for a longer disease-free survival. Loss of @entity6756 expression was correlated with a significantly higher intraepithelial @entity405 + and @entity4755 + cell infiltration. We conclude that infiltration of @entity405 + and @entity4755 + cells are important prognostic factors in @entity14 . However, their interaction with @entity5 cells is inversely correlated to the presence of HLA-I on @entity5 cells and a thick BM-like structure around @entity5 islets. Our data indicate that NK cells might play an important role in the immune surveillance in @entity14 @entity1 .
