Increased prevalence of prolonged QT interval in males with primary or secondary XXXX : a pilot study.

@entity1 @entity251 @entity54671 @entity6126 @entity943 @entity14136
Symptoms and signs of @entity14136 span all organ systems, including the cardiovascular apparatus. The electrocardiographic QT interval reflects cardiac ventricular repolarization and, if prolonged, increases the risk of malignant @entity943 . QT interval duration is similar in @entity1 and @entity1 during childhood, but shortens in males after puberty and experimental studies suggest that @entity251 is a major contributor to shortening of QT interval in @entity1 . The aim of the present pilot study was to assess the duration of ventricular repolarization in adult males with primary or secondary @entity6126 . Standard ECG recordings were performed in 26 @entity1 (mean age 39.2 +/- 2.17 years) with @entity54671 and repeated in 15 @entity1 during @entity251 replacement. Twenty-six age-matched control @entity1 were also analysed. Measured QT intervals were corrected for heart rate according to Bazzett's formula (QTc = QT/radical RR interval). The prevalence of prolonged QTc was considerably higher in hypogonadal @entity1 (four of 26 @entity1 ) than in control @entity1 (none, p < 0.05) and in the general, healthy population (<2.5%). QTc interval normalized on hormone replacement therapy in the four @entity1 presenting prolonged QTc in the hypogonadal state. Heart rate and left ventricular mass did not differ among the two groups and no known QT-prolonging factor was apparent in @entity1 with abnormal QTc interval. In conclusion, a high number prolonged QT interval measurements was observed in hypogonadal @entity1 who may therefore be at increased risk for @entity943 . This observation reveals an additional feature of @entity14136 , which may benefit from @entity251 replacement therapy.
