@entity876 mutations in @entity189 : a comparison of solitary and multiple primary @entity5 and lymph node XXXX .

@entity1 @entity5 @entity957 @entity2 @entity189 @entity876 @entity3
Despite the steadily increasing number of @entity1 suffering from @entity957 of the oropharyngeal region, little is known about the molecular steps involved in the induction of these @entity5 . The aim of this study was to determine the incidence and type of @entity876 mutations in @entity957 . Five of 38 @entity1 had lymph node @entity3 , three @entity1 had multiple primary @entity189 and two @entity1 presented with multiple primary @entity5 and lymph node @entity3 . Exons 5 through 8 of the @entity876 gene were screened by single-strand conformation polymorphism analysis followed by direct DNA sequencing. A total of 16 @entity5 (42%) contained point mutations scattered throughout exons 5 to 8. Most mutations (56%) were transitions, predominantly G-->A. G-->T mutations prevailed among the transversions that have also been found in smoking-related @entity2 . One @entity189 showed a mutation which was retained in a lymph node @entity3 . The status of @entity876 differed in primary @entity189 of @entity1 with @entity5 indicating an independent generation of these @entity5 . The frequent occurrence of @entity876 mutations in @entity189 supports the view that this gene plays a role in initiation or progression of the malignant phenotype.
