Patterns of XXXX recurrence in localized resected @entity157 .

@entity1 @entity157 @entity5
BACKGROUND: Tumor resection in non-metastatic @entity157 ( @entity157 ) @entity1 with adequate liver reserve offers a potential cure, but has a high 5-year recurrence rate. We analyzed the patterns of @entity5 relapse after partial hepatectomy to guide post-operative management. METHODS: A total of 144 @entity157 @entity1 (1996-2011) after partial hepatectomy were reviewed. Statistical correlations were determined using univariate and partition analyses. RESULTS: A median follow-up of 20 months showed recurrence in 71 (49%) @entity1 , and the median time to recurrence was 11.9 months. Vascular invasion (P<0.01) and number of lesions (P<0.01) predicted for recurrence. Histologic grade was not correlated with recurrence. Twenty-two (31%) @entity1 developed both surgical margin (SM) and concurrent intrahepatic recurrences, and 28 (40%) had non-SM intrahepatic recurrences with no other signs of recurrence. On partition analysis, the risk of marginal recurrence in @entity1 with SM <1 mm and SM >= 1 mm was 35% and 13.5% respectively. Approximately 57% of @entity1 with intrahepatic recurrence had recurrence  <=2.5 cm from SM. CONCLUSIONS: Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and @entity5 stage. About 57% of @entity1 with intrahepatic relapse had a recurrence close ( <=2.5 cm) to the SM. Additionally, @entity1 with SM <1 mm have a higher recurrence rate and may benefit from adjuvant local therapy.
