Survival After Distant Metastasis in XXXX .

@entity1 @entity135 @entity3
BACKGROUND/AIM: In addition to locoregional recurrence distant @entity3 can limit the survival of @entity1 with @entity135 . The aim of the study was to analyze survival after distant metastasis of @entity135 . @entity1 AND METHODS: @entity1 with @entity135 and M0 status at initial diagnosis, who were treated with curative intent but developed distant @entity3 without synchronous locoregional recurrence were analyzed. Predictors for the duration of survival were evaluated using Cox regression analysis. RESULTS: A total of 46 @entity1 developed distant @entity3 which were detected after a mean time of 16 months, most were lung (59%) and bone @entity3 (24%). The most common therapy for distant metastasis was palliative chemotherapy; due to poor general condition, 21% of @entity1 were treated with best supportive care. The mean survival was 7.5 months, the overall survival at 1 and 2 years after diagnosis of distant metastasis were 40.4% and 26.2%, respectively. Regression analysis showed no significant predictors for prolonged survival, however, the three @entity1 surviving at the time of data collection were treated by surgical resection of solitary @entity3 . CONCLUSION: In cases of distant @entity3 , due to poor prognosis of the @entity1 , palliation is important and the treatment approach should be chosen taking into account the general condition of the @entity1 . In individual cases, resection of solitary @entity3 may be useful.
