Inhibitory effects of high stability @entity46469 on @entity7609 -induced lipid accumulation in XXXX adipose-derived stem cells through modulation of long non-coding RNA.

@entity46469 @entity1 @entity137 @entity66 @entity28 @entity26 @entity3088 @entity7609
UNASSIGNED: Obesity is a serious worldwide disease, which is growing in epidemic proportions. Adipose-derived stem cells (ADSCs) are characterized as a source of mesenchymal stem cells that have acted as a potential application for regeneration. Recently, seaweeds rich in @entity3088 and polysaccharides have been supposed to show the ability to modulate risk factors for @entity28 and @entity66 . In the present study, we investigated the anti- @entity28 properties of high stability @entity46469 (HS-Fx) derived from brown seaweeds on the adipogenesis of ADSCs upon treatment with @entity7609 (PA). First, we showed the differentiation capability of ADSCs from morbid @entity28 @entity1 to transform into different cell types. Second, we found that the co-treatment of ADSCs with HS-Fx and PA showed no significant @entity137 against ADSCs, but PA induced the elevation of reactive @entity26 species (ROS) and lipid droplet accumulation was abolished. Thirdly, the PA-mediated down-regulation of lipid metabolism genes was reversed by the treatment of HS-Fx. By long non-coding RNAs (lncRNAs) screening, we found that PA-induced increases in the targeted lncRNAs were also decreased upon treatment with HS-Fx. On Silencing, these lncRNAs corresponded to the decrease in the lipid droplet accumulation of ADSCs induced by PA. ADSCs from @entity28 @entity1 would be direct and meaningful model cells to investigate the development of @entity28 and their treatments, rather than cell lines from other species. HS-Fx showed anti- @entity28 capability through modulating the elevation of ROS, down-regulation of lipid metabolism genes induced by PA, and upstream signaling, which might be critically resulted from the expression of lncRNAs.
