Administration of glycoprotein IIb-IIIa inhibitors in @entity1 with ST-segment elevation XXXX .

@entity1 @entity63 @entity1188 @entity1427 @entity583
@entity1 with ST-segment elevation acute @entity583 require immediate reperfusion therapy. Reperfusion therapy can be provided by either pharmacologic or mechanical means. Pharmacologic reperfusion therapy consists of administering fibrinolytics, whereas mechanical reperfusion consists of performing percutaneous intervention, usually with stent placement. Each approach has been shown to decrease mortality, but each has disadvantages in establishing flow in the @entity1188 . Regardless of the approach, during an acute @entity583 , activation and externalization of glycoprotein (GP) IIb-IIIa receptors occur on the surface of platelets. The @entity1427 -IIIa inhibitors block the binding of fibrinogen to these platelet receptors. These inhibitors have been investigated in combination with both reperfusion strategies. The goal of adding @entity1427 -IIIa inhibitor therapy to either reperfusion approach is to obtain better early, complete, and sustained reperfusion. Subsequently, this should lead to better clinical outcomes for @entity1 with ST-segment elevation acute @entity583 . Although no mortality benefit has been seen with the addition of @entity1427 -IIIa inhibitor therapy, @entity63 have been reduced significantly.
