Cells expressing dendritic cell markers are present in the XXXX .

@entity309 @entity5750 @entity75 @entity8730 @entity14931 @entity72750 @entity4896
OBJECTIVE: To determine if dendritic antigen-presenting cells (DC) are present in rheumatoid nodules, as has been reported in the @entity75 of @entity309 . METHODS: Nodules (n = 14) were examined with monoclonal antibodies (Mab) recognizing the DC differentiation/activation markers @entity8730 , CMRF44, and @entity72750 and an antibody recognizing the @entity4896 antigen present on epithelial tissue associated DC. Results. Cells expressing CMRF44 were common in rheumatoid nodules, comprising 22% of nucleated cells versus 13% in synovial membranes (n = 10). Cells positive for @entity4896 (5%) and @entity8730 (2%) were less common. A majority (86%) of CMRF44 positive cells were also positive for the macrophage marker @entity5750 . This left a significant minority of putative DC that were single stained with CMRF44. CONCLUSION: Cells bearing DC markers are as frequent in the @entity14931 as in the @entity75 . A majority are "indeterminate" cells that are @entity5750 positive but a proportion are single stained putative DC. The lack of lymphoid collections containing DC and T and B lymphocytes in the nodule suggests that local presentation of antigen may not occur in the @entity14931 , as is thought to be the case in synovial membranes containing lymphoid follicles. This difference could potentially be explained by different states of activation, and differentiation of DC within the 2 lesions.
