Intermittent cycles of remote ischemic preconditioning augment XXXX healing.

@entity1 @entity1066 @entity6 @entity4760
UNASSIGNED: The morbidity and mortality caused by @entity4760 ( @entity4760 ) are still significant. Conservative treatment of @entity4760 is often ineffective. Treatment modalities using stem cells directly into the @entity4760 or systematically have been introduced recently. Ischemic preconditioning (IPC) has been proved to be a cheap, simple, and safe method which can augment stem cells number in the peripheral blood circulation. This study's purpose was to test whether IPC can improve @entity4760 healing. Forty @entity6 @entity1 were enrolled and divided into study and control groups. All @entity1 received their regular treatment. The study group @entity1 received in addition brief, transient cycles of IPC while the control group @entity1 received a sham procedure only. The procedure was repeated every 2 weeks to complete a follow-up period of 6 weeks. The @entity1066 were photographed to measure wound area, and the degree of granulation tissue was assessed. No serious adverse events were noted. Twenty-two @entity1 from the study group and 12 from the control group completed the entire follow-up. The ratio of @entity1 who reached complete healing of their ulcer was 9/22 (41%) in the study group compared with 0/12 (0%) in the control group, p   =   0.01. Furthermore, the mean remaining ulcer area at the end of the follow-up was significantly smaller in the study group, 25        6% of the initial area vs. 61        10% in the control group, p   =   0.007. The degree of granulation increased after one cycle of treatment in 8/24 (33%) study @entity1 compared to 3/16 (19%) in the control group, p   =   0.47. Remote, repeated IPC significantly improves the healing of @entity4760 . This simple, safe, inexpensive treatment method should be considered to be routinely applied to @entity6 @entity1 with @entity4760 in addition to other regular treatment modalities.
