Effects of combined extract of XXXX , coffee, green tea and garcinia on lipid profiles, glycaemic markers and inflammatory responses in hamsters.

@entity644 @entity32 @entity137 @entity66 @entity1560 @entity1674 @entity329 @entity3645 @entity6353 @entity165
BACKGROUND: Dyslipidaemia is highly associated with cardiovascular and @entity66 , which have been ranked second and third place of leading causes of death in Taiwan. Some plant extracts have been proved effective against dyslipidaemia. However, the combination of plant extracts was rarely studied. The purpose of the present study is to understand the beneficial effects of a combined extract (comprising @entity6353 , coffee, green tea and garcinia; CCGG) on lipid profiles in serum, liver, and faeces as well as glycaemic markers and related proinflammatory cytokines by using an appropriate animal model, the golden @entity329 . METHODS: A total of 40 male hamsters were randomly assigned to five groups: (1) vehicle control, (2) high- @entity165 diet control, (3) high- @entity165 diet of 311  mg/kg/d of CCGG, (4) high- @entity165 diet of 622  mg/kg/d of CCGG and (5) high- @entity165 diet of 1555  mg/kg/d of CCGG. At the end of the experiment, blood, tissue and faecal samples were collected for further analysis. RESULTS: After 6 weeks of treatment, CCGG supplementation significantly reduced serum lipid content ( @entity1674 , total @entity165 and LDL-C) and hepatic lipid content ( @entity1674 and @entity165 ) with dose-dependent effects. In addition, an @entity644 ( @entity3645 ) was observed after supplementation. Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) index and serum proinflammatory cytokine levels (TNF-a and IL-6) involved in dyslipidaemia was markedly improved. In addition, by monitoring biochemical parameters as well as histopathology of major tissues, no @entity137 was observed after the consumption of CCGG. CONCLUSION: Dietary CCGG supplementation may exert potential effects on ameliorating hyperlipidaemia, insulin resistance, @entity1560 and related @entity32 .
