Radiation Dose to the Penile Structures and @entity1 -Reported XXXX in Long-Term @entity263 Survivors.

@entity1 @entity323 @entity263 @entity409 @entity158 @entity250
AIM: The involvement of various penile structures in radiotherapy (RT)-induced @entity263 survivors remains unclear and domains beyond @entity323 such as orgasm, and @entity158 have typically not been considered. The purpose of this study was to investigate @entity250 post-RT for @entity263 and to examine whether radiation dose to different penile structures can explain these symptoms. METHODS: We investigated @entity250 in two treated @entity263 cohorts and in one non-pelvic-irradiated cohort, 328 sexually active @entity1 part of an unselected, population-based study conducted in 2008. The treated subjects were prescribed primary/salvage external-beam RT to 70 Gy@2.0 Gy/fraction. Absorbed RT doses (Dmean and Dmax ) of the corpora cavernosa (CC), the penile bulb (PB), and the total penile structure (CC   +   PB) were related to 13 @entity1 -reported symptoms on @entity250 by means of factor analysis (FA) and logistic regression. RESULTS: Three distinct symptom domains were identified across all cohorts: " @entity323 " ( @entity323 , two to five symptoms), " @entity409 " ( @entity409 , two to four symptoms), and " @entity158 " (two to three symptoms). The strongest predictor for @entity323 symptoms was CC   +   PB Dmax (P   =   0.001-0.03), CC and PB Dmean predicted @entity409 symptoms equally well (P   =   0.03 and 0.02-0.05, respectively), and the strongest predictor for @entity158 symptoms was CC   +   PB Dmean (P   =   0.02-0.03). CONCLUSION: @entity250 following RT was separated into three main domains with symptoms related to @entity323 , @entity409 , and @entity158 . Chances for intact sexual functionality may be increased if dose to the total penile structure can be restricted for these domains in the planning of RT. Thor M, Olsson CE, Oh JH, Alsadius D, Pettersson N, Deasy JO, and Steineck G. Radiation dose to the penile structures and @entity1 -reported @entity250 in long-term @entity263 survivors. J Sex Med **;**:**-**.
