Evaluation of gamma knife radiosurgery in the treatment of XXXX and mixed oligodendroastrocytomas.

@entity1 @entity5 @entity11 @entity10814 @entity816 @entity3271
OBJECT: Radiosurgery is commonly used for the treatment of @entity1 with @entity11 . The goal of this study was to evaluate the safety and efficacy of radiosurgery in the management of @entity1 with @entity3271 ( @entity3271 ) or mixed @entity816 ( @entity816 ). METHODS: A retrospective chart review of @entity1 treated between May 1990 and January 2000 identified 18 @entity1 (21 @entity5 ) with either an ODG (10) or a mixed @entity10814 (11) who had undergone radiosurgery. The median @entity1 age was 43 years (range 23-67 years). Sixteen @entity1 had undergone one or more @entity5 resections before radiosurgery; in two @entity1 biopsy sampling alone had been performed. @entity5 grades at the most recent operation were Grade I (one), Grade 2 (one), Grade 3 (12), and Grade 4 (seven @entity1 ). Seventeen @entity1 had undergone prior radiotherapy; 11 were treated with chemotherapy before radiosurgery, and one had undergone a prior linear accelerator-based radiosurgery treatment. The median @entity5 volume was 8.2 cm3 (range 1.9-47.7 cm3); the median margin dose was 15 Gy (range 12-20 Gy); and the median maximum dose was 32 Gy (range 24-50 Gy). In this heterogeneous group, 12 @entity1 died whereas six remain alive. Survival after radiosurgery was 78%, 61%, and 44% at 12, 24, and 48 months, respectively. Factors associated with an improved survival rate included younger age and smaller @entity5 . CONCLUSIONS: For @entity1 with @entity5 that have failed to respond to conventional therapies, radiosurgery may provide some survival benefit. Further study is needed to determine which subpopulation of these @entity1 will have the best chances of enhanced survival from this treatment.
