Antishock effect of U-67,590A, @entity73220 , associated with restoration of lowered vascular reactivity in endotoxemic XXXX .

@entity73220 @entity5694 @entity551 @entity1617 @entity134 @entity35 @entity1063 @entity4338 @entity526 @entity934
We wished to investigate the modulating effects of a glucocorticoid on mortality and sustained @entity551 in endotoxemic @entity35 in conjunction with in vitro study of responses of isolated aorta to @entity4338 , @entity1063 (NE), and @entity934 ( @entity1617 ). @entity5694 was induced by intravenous (i.v.) bolus injection of 50 mg/kg @entity526 endotoxin in @entity35 , resulting in high mortality. Pretreatment with U-67,590A, @entity73220 , at a dose of 9 mg/kg resulted in 100% survival; the survival rate of saline-treated controls was 21%. Isolated @entity35 aorta that had been treated with endotoxin for 4 h showed decreases in contractile responses to @entity4338 and NE and in relaxing response to @entity1617 . Similar attenuation of contractile responsiveness was observed in endothelium-denuded preparations. Addition of endotoxin to the in vitro tissue bath did not inhibit the responses in a 4-h period. Pretreatment with @entity73220 inhibited the late gradual decrease in blood pressure (BP) but not the early @entity551 response to endotoxin. The responses to @entity4338 or NE of aorta isolated 4 h after the endotoxin injection remained suppressed in U-67,590A-treated @entity35 but were restored in 24 h. These results suggest that @entity5694 impairs the endothelium moderately, but this does not account for either reduced reactivity of vascular smooth muscle to vasoconstrictor agents or the sustained @entity551 . The @entity134 inhibits @entity5694 -induced mortality and sustained @entity551 .
