@entity1091 clearance measurements as an indication of XXXX nephrotoxicity in the rat.

@entity870 @entity1372 @entity205 @entity2507 @entity10200 @entity972 @entity1011 @entity1091
1. Measurements of the rate of @entity1091 clearance, which provides an estimate of proximal renal tubular iso-osmotic reabsorption (i.e. @entity1372 and @entity2507 ), were used to study @entity2507 and electrolyte reabsorption during the development of @entity205 ( @entity870 ) induced nephrotoxicity. 2. CsA, administered daily by gavage at 50 mg/kg body weight, produced a nephrotoxicity which was characterized by reductions in the clearance rates of @entity1011 , @entity1372 and @entity972 , and increased @entity10200 , enzymuria and urine flow rate. 3. Decreased @entity1091 clearance rate and increased proximal iso-osmotic reabsorption accompanied significant reductions in @entity1011 clearance rate. Absolute proximal tubular reabsorption, however, was not affected by CsA administration. 4. Reductions in the absolute distal tubular reabsorption of @entity1372 , @entity972 and @entity2507 were also observed. 5. Alterations in renal tubular function occur early in the development of CsA nephrotoxicity as a result of both direct proximal tubulotoxicity and an effect on the afferent arteriole. 6. Measurements of the rate of @entity1091 clearance may be a useful adjunct to the diagnosis of CsA nephrotoxicity.
