Prospective Evaluation of Associations Between Prenatal XXXX and Adulthood Coronary Heart Disease Risk: The New England Family Study.

@entity1 @entity6 @entity301 @entity701 @entity165
OBJECTIVE: Increasing evidence suggests that early life factors may influence @entity301 ( @entity301 ) risk; however, little is known about the contributions of prenatal @entity701 . Objectives were to prospectively assess the associations of maternal @entity701 levels during pregnancy with offspring's 10-year @entity301 risk during middle age. METHODS: @entity1 were 262 mother-offspring dyads from the New England Family Study. Maternal free @entity701 was assessed in third-trimester maternal serum samples. Ten-year @entity301 risk was calculated in offspring at a mean age of 42 years, using the validated Framingham risk algorithm incorporating @entity6 , systolic and diastolic blood pressure, total and high-density lipoprotein @entity165 , smoking, age, and sex. RESULTS: In multivariable-adjusted linear regression analyses adjusted for age and race/ethnicity, high versus low maternal @entity701 tertile was associated with 36.7% (95% confidence interval [CI] = 8.4% to 72.5%) greater mean 10-year @entity301 risk score in @entity1 . There was no association in @entity1 (-2.8%, 95% CI = -23.8% to 24.0%). Further adjustment for in utero socioeconomic position showed 26.1% (95% CI = -0.5% to 59.9%) greater @entity301 risk in @entity1 . Adjustment for maternal age and size for gestational age had little effect on findings. CONCLUSIONS: Maternal prenatal @entity701 levels were positively associated with 10-year @entity301 risk among female, and not male, offspring. Adjusting for socioeconomic position during pregnancy reduced effect size in @entity1 , suggesting that it may be a common prior factor in both maternal @entity701 and @entity301 risk. These findings provide evidence that targeting mothers who have elevated prenatal @entity701 levels, including elevated @entity701 in the setting of low socioeconomic position, may potentially reduce long-term @entity301 risk in their offspring.
