Effect of acute XXXX and @entity520 on intestinal electrolyte transport in vivo.

@entity5838 @entity8777 @entity3884 @entity1219 @entity2865 @entity1372 @entity3157 @entity5993 @entity520 @entity74 @entity972 @entity35
The effects of acute @entity5838 and @entity520 on intestinal electrolyte transport were studied in adult @entity35 . Animals were made alkalotic or acidotic by gavage feeding of 1 M solutions of @entity1219 (pH = 7.42), @entity5993 (pH = 7.52), @entity8777 (pH = 7.18), or 0.75 M (NH4)2SO4 (pH = 7.21). After 1-3 h, animals were anesthetized and prepared for in vivo perfusion of the jejunum, ileum, and colon. The jejunum exhibited increased net @entity972 absorption in @entity5838 and decreased @entity972 absorption in @entity520 . In the ileum, net @entity1372 absorption and @entity972 secretion were decreased, and @entity3157 secretion was increased in @entity5838 , and opposite effects were observed in @entity520 . The ileal lumen minus blood gradient for PCO2 (an index of @entity3884 ion secretion) was greater in acidotic than in alkalotic animals. The levels of ileal @entity1372 , @entity3157 , and @entity972 transport and the PCO2 gradient correlated well with the plasma pH and @entity3157 concentration in individual animals. In the colon, net @entity3157 secretion and @entity2865 absorption increased and @entity972 secretion decreased in @entity5838 , and opposite effects were observed in @entity520 . The colonic lumen minus blood PCO2 gradient was not affected by acid-base balance. Colonic @entity3157 transport correlated with the plasma @entity2865 concentration as well as with the plasma pH. The @entity74 had no effect on transmural potential difference. These results suggest that acute @entity5838 and @entity520 alter @entity1372 and @entity3884 ion transport in the ileum and @entity2865 and @entity3157 transport in the colon.
