Efficacy and safety of stenting for elderly @entity1 with severe and symptomatic XXXX : a critical meta-analysis of randomized controlled trials.

@entity1 @entity129 @entity64 @entity2998 @entity551 @entity1410 @entity583 @entity543 @entity1168 @entity204
OBJECTIVE: To investigate both short-term and long-term therapeutic efficacy and safety of @entity2998 ( @entity2998 ) and carotid artery endarterectomy (CEA) for elderly @entity1 with severe and symptomatic @entity543 . METHODS: PubMed, EMBASE, Cochrane Library, Clinical Trials Register Centers, and Google Scholar were comprehensively searched. After identifying relevant randomized controlled trials, methodological quality was assessed by using Cochrane tools of bias assessment. Meta-analysis was performed by RevMan software, and subgroup analyses according to different follow-up periods were also conducted. RESULTS: Sixteen articles of nine randomized controlled trials containing 6,984 @entity1 were included. Compared with CEA, @entity2998 was associated with high risks of @entity64 during periprocedural 30 days (risk ratio [RR]=1.47, 95% confidence interval [CI]: 1.15-1.88), 48 months (RR=1.37, 95% CI: 1.11-1.70), and >48 months (RR=1.76, 95% CI: 1.34-2.31). There was no significant difference in the aspects of @entity204 , disabling @entity64 , or @entity204 at any time between the groups. For other periprocedural complications, @entity2998 decreased the risk of @entity583 (RR=0.44, 95% CI: 0.26-0.75), @entity129 (RR=0.09, 95% CI: 0.04-0.22) and @entity1410 (RR=0.31, 95% CI: 0.14-0.68) compared with CEA, while it increased the risk of @entity1168 or @entity551 (RR=8.45, 95% CI 2.91-24.58). CONCLUSION: Compared with CEA, @entity2998 reduced @entity1410 , periprocedural @entity583 , and @entity129 , while it was associated with higher risks of both short-term and long-term nondisabling @entity64 . And they seemed to be equivalent in other outcome measures. As regards to its minimal invasion, it should be applied only in specific @entity1 .
