Treatment of XXXX of the Jaw.

@entity1 @entity115 @entity174 @entity15896 @entity4 @entity170 @entity5520 @entity292 @entity89 @entity3061 @entity63038 @entity2530
The definition of @entity5520 -related @entity89 (BRONJ) was recently broadened and it is now known as medication-related @entity89 (MRONJ). To date, the management of MRONJ is controversial. Conservative treatment is recommended, but it is difficult to successfully treat stage 3 MRONJ. Administration of @entity15896 for the MRONJ treatment has only been documented in independent case reports and there are few reports on @entity1 with MRONJ treated with @entity15896 . An 81-year-old @entity1 was referred in May 2014 for treatment of an unhealed tooth extraction wound in the mandible. He took @entity63038 (1mg/d orally) for 2 years because of @entity170 cure. On clinical examination, soft tissue @entity4 in the left mandibular first molar region extended to the inferior border of the mandible with extraoral @entity292 . Computed tomography (CT) revealed @entity3061 extending to the inferior border resulting in pathologic @entity174 of mandibular bone. Based on these findings, a diagnosis of stage 3 MRONJ was made. We performed conservative treatment, including @entity115 , but his symptoms did not improve. He was then treated with once-weekly subcutaneous injection of @entity15896 . Although @entity15896 injections were started without antibiotics, after 1 week, @entity4 , erythema, and purulent discharge from the extraoral @entity292 increased rapidly. Therefore, we combined the once-weekly @entity15896 injection with @entity115 administration. Three months later, the @entity2530 had healed and CT showed significant bone regeneration and healing of the mandibular pathologic @entity174 . In addition, the mandibular @entity292 showed healing and the intraoral @entity292 was covered with normal mucosa.
