Continuous Subcutaneous @entity2690 Infusion in Neonates and XXXX Below 1 Year: Analysis of Initial Bolus and Basal Rate Based on the Experiences from the German Working Group for Pediatric Pump Treatment.

@entity1 @entity2690 @entity6
BACKGROUND: @entity6 is rare in young @entity1 and neonates. Continuous subcutaneous @entity2690 infusion (CSII) is used most frequently for @entity2690 treatment in this age group. However, the individual doctor's experience is scarce because of the low prevalence of @entity6 in this age. For this study @entity1 treated with CSII with an age below 1 year were selected from the German/Austrian @entity6 ( @entity6 ) database, and basal rate and bolus calculation were described. MATERIALS AND METHODS: For all @entity1 less than 1 year of age, basal rate and mealtime boluses were compared among @entity1 with @entity6 ( @entity6 ), @entity1 with @entity6 ( @entity6 ), and infants with @entity6 ( @entity6 ). RESULTS: Fifty-eight @entity1 with @entity6 , 67 neonates with @entity6 , and 43 @entity1 with early @entity6 development after 6 months and negative b-cell antibodies ( @entity6 ) could be analyzed. @entity6 @entity1 at onset required a median total @entity2690 amount of 0.83   IU/kg of body weight, whereas @entity6 @entity1 required 0.74   IU/kg of body weight (P   =   0.63). Basal @entity2690 requirement however, was different between the two groups (0.56   IU/kg of body weight in @entity6 vs. 0.43   IU/kg in @entity6 ) (P   =   0.036). The percentage basal profile of @entity6 and @entity6 @entity1 was quite similar to @entity1 at the age of 1-5 years. The proportion of prandial @entity2690 at onset was significantly different (32% in @entity6 vs. 53% in @entity6 ) (P   <   0.00001). @entity6 @entity1 showed almost similar data to @entity6 @entity1 . The pattern of mealtime bolus @entity2690 was not different among the groups. CONCLUSIONS: The presented data can be used as an initial guide value to start CSII treatment in neonates and @entity1 . To be on the safe side we recommend the lower quartile for the dosage as the starting value in nonketotic @entity1 .
