Comparison of the thrombolytic efficacy of defibrase and urokinase on @entity235 coronary artery thrombosis and the mechanism of urokinase-induced XXXX .

@entity548 @entity235 @entity1003 @entity1188 @entity920 @entity715 @entity943
The thrombolytic efficacy of defibrase (DF) and urokinase (UK) was evaluated and compared in a @entity235 model in which left circumflex coronary artery (LCX) @entity715 formation was initiated by electrical stimulation (150 UA, DC) of the arterial intimal surface via an implanted @entity920 wire electrode. Forty-eight mongrel @entity235 were equally divided into 8 groups: six groups for both intravenous (iv) and intracoronary (ic) infusion of DF, UK and normal saline 30 min after complete obstruction by a LCX @entity715 , the remaining two groups for iv infusion DF and UK 360 min after occlusion. Results showed that in the control groups no LCX recanalization after infusion occurred, but all the treated groups recanalized when drug infusion started 30 min after occlusion. @entity715 wet weight and @entity1188 size were much higher in the control group. No significant differences were found between treated groups except that the recanalizing speed was fastest by ic UK with the highest occurrence rate of reperfusion @entity943 . For 6-hour-old thrombi, DF was more effective than UK for recanalization. @entity715 wet weight and @entity1188 size were lower in the recanalized @entity235 . Both agents reduced plasma plasminogen and fibrinogen significantly but serious incision @entity548 was only found in the UK group. In order to study the mechanism underlying UK-induced @entity548 , we observed the influences of UK and DF on @entity1003 factors in another 12 @entity235 . Results showed that DF only reduced factor 1 while UK additionally reduced coagulation factors 2, 7, 8 and 10, indicating that the non-selective depletive effect on coagulation factors may be one of the mechanisms of UK-induced @entity548 . We conclude that both DF and UK can lyse fresh coronary thrombi, DF was more effective than UK on lysing older thrombi, considering its convenient use and less frequency of side effects, DF is therefore considered a more promising agent clinically.
