Physical Activity and Risk of @entity301 and XXXX in Older Adults: The Cardiovascular Health Study.

@entity1 @entity64 @entity301 @entity583 @entity204 @entity65 @entity385
BACKGROUND: Although guidelines suggest that older adults engage in regular physical activity (PA) to reduce @entity65 ( @entity65 ), surprisingly few studies have evaluated this relationship, especially in those >75 years. In addition, with advancing age the ability to perform some types of PA might decrease, making light-moderate exercise such as walking especially important to meet recommendations. METHODS AND RESULTS: Prospective cohort analysis among 4207 US @entity1 and @entity1 of a mean age of 73 years (standard deviation=6) who were free of @entity65 at baseline in the Cardiovascular Health Study were followed from 1989 to 1999. PA was assessed and cumulatively updated over time to minimize misclassification and assess the long-term effects of habitual activity. Walking (pace, blocks, combined walking score) was updated annually from baseline through 1999. Leisure-time activity and exercise intensity were updated at baseline, 1992, and 1996. Incident @entity65 (fatal or nonfatal @entity583 , @entity204 , or @entity64 ) was adjudicated using medical records. During 41   995 @entity1 -years of follow-up, 1182 @entity65 events occurred. After multivariable adjustment, greater PA was inversely associated with @entity301 , @entity64 (especially @entity385 ), and total @entity65 , even in those >= 75 years. Walking pace, distance, and overall walking score, leisure-time activity, and exercise intensity were each associated with lower risk. For example, in comparison with a walking pace <2 mph, those that habitually walked at a pace >3 mph had a lower risk of @entity301 (0.50; confidence interval, 0.38-0.67), @entity64 (0.47; confidence interval, 033-0.66), and @entity65 (0.50; confidence interval, 0.40-0.62). CONCLUSIONS: These data provide empirical evidence supporting PA recommendations, in particular, walking, to reduce the incidence of @entity65 among older adults.
