Aqueous Flare as an Indicator of Response to XXXX Treatment in @entity2994 : A Pilot Study.

@entity1 @entity2994 @entity4 @entity619 @entity1020
PURPOSE: To investigate aqueous flare change patterns in @entity2994 ( @entity2994 ) following intravitreal application of @entity619 implant. To evaluate the correlations between @entity1020 ( @entity1020 ), best corrected visual acuity (BCVA) and aqueous flare values. METHODS: This prospective, interventional pilot study included 40 eyes of 40 @entity1 with macular @entity4 associated with @entity2994 . All @entity1 received intravitreal injection of @entity619 implant at baseline visit. Full ophthalmologic examination, @entity1020 and aqueous flare measurements were performed prior to injection and repeated at months 1, 3, and 5. Aqueous flare, BCVA and @entity1020 changes between visits were assessed. Further statistical analysis was performed to investigate correlations between these three parameters. RESULTS: The @entity1 consist of 23 (57.5%) @entity1 and 17 (42.5%) @entity1 with a mean age of 65.7        6.2 years. Of the 40 eyes, 24 (60%) had @entity2994 and 16 (40%) had central @entity2994 . BCVA (log   MAR) was significantly correlated with aqueous flare at each visit (r   =   0.436, p      =   0.005; r   =   0.349, p   =   0.027; r   =   0.357, p   =   0.024; r   =   0.551, p   =   0.000, respectively). Flare values were also correlated with @entity1020 measurements in 3rd and 5th months (r   =   0.324, p   =   0.042; r   =   0.556, p   =   0.000, respectively). Comparing the percentage change in @entity1020 and flare values over time, the change in @entity1020 from baseline to 3rd and 5th months (r   =   0.441, p   =   0.004, r   =   0.448, p   =   0.004), from 1st month to 3rd and 5th months (r   =   0.441, p   =   0.004; r   =   0.461, p   =   0.003) and from 3rd month to 5th month were directly correlated with aqueous flare changes (r   =   0.584, p   =   0.000). Twenty-two eyes (55%) required second @entity619 implant application at 5th month. CONCLUSION: Considering the inflammatory base of @entity2994 , @entity619 implants effectively decreased the flare values in the anterior chamber. The @entity1020 change was directly correlated with aqueous flare values.
