Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of XXXX .

@entity1552 @entity1476 @entity5 @entity3928 @entity2843 @entity201 @entity1495
BACKGROUND: The intraductal growth (IG) type of @entity201 has a better prognosis than the @entity3928 ( @entity3928 ) and periductal infiltrating (PI) types. @entity1476 and @entity1495 , regulated by @entity1552 and @entity2843 , respectively, play important roles in the degradation of the basement membrane during @entity5 invasion. Alteration in MMPs and TIMPs may regulate the gross morphology of @entity201 . METHODS: @entity1476 and @entity1495 were analyzed in 35 @entity201 and 4 normal livers with fresh tissue using zymography and real-time reverse transcription-polymerase chain reaction (RT-PCR), and expressions of @entity1476 , @entity1495 , @entity2843 , and @entity1552 were evaluated in 76 @entity201 by immunohistochemistry. RESULTS: Activity of @entity1476 and its active form were detected in 80% and 57% of @entity201 respectively. The total @entity1476 , active 62 kDa @entity1476 , and @entity1476 mRNA increased 5.4 and 8.2 times, 4.4 and 10.9 times, and 2.9 and 5.8 times in the @entity3928 and PI types, respectively, compared to the IG type. The majority of @entity1495 was in the proform and active 82 kDa @entity1495 was detected in 9% of @entity201 . @entity1495 revealed no significant difference in relation to the gross types. The balanced expressions of @entity1476 / @entity1552 and @entity1495 / @entity2843 were significantly decreased in the @entity3928 and PI types, compared to the IG type. In the normal and nonneoplastic livers, the expressions of @entity1476 and @entity1495 were very low without active forms. CONCLUSIONS: The activities of @entity1476 and loss of balanced expressions of @entity1476 / @entity1552 and @entity1495 / @entity2843 are suggested as playing important roles in invasive growth related to the gross type of @entity201 .
