Immunochemical studies of XXXX -associated neuropathology.

@entity35 @entity3323 @entity1885
An immunohistochemical study on neurofilaments (NF) in the central and peripheral nervous systems of @entity35 after repeated treatment with @entity3323 was done by the avidin- @entity1885 complex method using monoclonal anti-neurofilaments antibodies (68, 160 and 200 kD). @entity35 were given @entity3323 (50 ml/kg) i.p. every day for 8 days. In the cerebrum, NF in perikarya of large nerve cells were weakly stained with all antibodies in both control and treated @entity35 , with no differences between the 2 groups. In the cerebellum, NF of the Purkinje cells were slightly stained with all 3 antibodies. In the treated @entity35 , a marked accumulation of NF in the distal part of the basket cell fibers was detected by 68 kD. In the molecular layer, some parallel fibers were also stained by 68 kD in the treated animals. In the spinal cord, all NF were stained, the staining being clearer in the lower part of the cord in the treated @entity35 . In the peripheral nerve of the treated @entity35 , many axons were segmentally swollen along the entire length of the nerve, especially, in the distal region. In muscle preparations of the treated @entity35 , some neuro-muscular junctions stained with 68 kD were also visible.
