Direct comparison of cardiac troponin I and cardiac troponin T in the detection of exercise-induced XXXX .

@entity1 @entity10020 @entity6949 @entity741
BACKGROUND: It is unknown, whether cardiac troponin (cTn) I or @entity10020 is the preferred biomarker in the detection of exercise-induced @entity741 . METHODS: We investigated @entity1 with suspected @entity741 referred for exercise or pharmacological rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) to directly compare the diagnostic accuracy of high-sensitivity @entity6949 (hs- @entity6949 ) and hs- @entity10020 . Diagnostic performance was analyzed separately according to stress modality. Hs- @entity6949 and hs- @entity10020 were measured before, immediately after, as well as 2h and 4h after maximal exercise in a blinded fashion. Further, all clinical information available to the treating cardiologist was used to quantify the clinical judgment regarding the presence of @entity741 using a visual analog scale twice: once prior and once after stress-testing. The presence of stress-induced @entity741 was adjudicated using SPECT combined with coronary angiography findings. RESULT: A total of 403 consecutive @entity1 were enrolled in our study, of which 229 underwent exercise stress and 174 @entity1 pharmacological stress. Exercise-stress-induced @entity741 was detected in 90 @entity1 (39.3% of 229). Levels of hs- @entity6949 and hs- @entity10020 were both significantly higher at all time-points examined in @entity1 with exercise-induced @entity741 as compared to @entity1 without @entity741 (all p<0.001). Correlation of hs- @entity6949 and hs- @entity10020 was high in direct comparison of time-points (Spearman's rho all >= 0.7). The AUCs for baseline/peak/2h/4h for hs- @entity6949 and hs- @entity10020 were 0.71/0.71/0.72/0.69 vs. 0.74/0.73/0.71/0.72, respectively (all p=ns for hs- @entity6949 versus hs- @entity10020 ). In @entity1 undergoing pharmacological stress, the AUCs for baseline/peak/2h/4h for hs- @entity6949 and hs- @entity10020 were 0.66/0.66/0.68/0.67 and 0.61/0.62/0.64/0.59, respectively (all p=ns for hs- @entity6949 versus hs- @entity10020 ). Also the combinations including clinical judgment or changes during serial sampling were similar for hs- @entity6949 and hs- @entity10020 (all p=ns). CONCLUSIONS: Hs- @entity6949 and hs- @entity10020 provide comparable diagnostic information regarding exercise-induced @entity741 . Overall, their diagnostic accuracy seems moderate. UNIQUE IDENTIFIER: NCT01838148.
