Biochemical and behavioral changes in @entity35 during and after chronic XXXX exposure.

@entity2254 @entity935 @entity1425 @entity2819 @entity854 @entity2339 @entity2922 @entity35 @entity1063
Two groups of @entity35 were implanted with ALZET minipumps to deliver vehicle or a theoretical amount of 1 mg/kg per h of @entity2254 (A) for 12 days. After 3 days of A-exposure, motor movements and stereotypic behavior were markedly increased. Subsequent testing during A-exposure showed that motor movements and stereotypic behavior remained significantly increased but declined. After removal of the pumps, these effects disappeared and no differences at rest, during stress or A challenge, were apparent in either group. Animals sacrificed after 3 days of drug exposure, showed a drastic decrease in cardiac, but not adrenal, @entity2922 levels. In the brain, @entity1063 (NE) levels were markedly decreased in the frontal cortex, @entity2339 , caudate, pons-medulla and cerebellum. @entity1425 (E) levels were unaffected and @entity935 (DA) levels were decreased in most areas without reaching statistical significance. Plasma @entity2819 levels were similar in both groups. Animals in both groups sacrificed about 25 days after pump removal were biochemically similar. Under our conditions, A-exposure produced marked behavioral and biochemical changes but there was no evidence of @entity854 after cessation of drug treatment.
