[Therapeutic effects of @entity3398 in the treatment of various infections in XXXX (author's transl)].

@entity1 @entity6747 @entity5443 @entity8174 @entity698 @entity796 @entity298 @entity526 @entity294 @entity327 @entity794 @entity797 @entity1576 @entity12277 @entity293 @entity221 @entity3398 @entity30773
In order to ascertain the therapeutic effects of @entity3398 ( @entity5443 ), a new semisynthetic @entity12277 antibiotic, it was administered to pediatric @entity1 with several infections. There were 8 @entity1 with @entity1576 ( @entity1576 ), 3 with @entity293 ( @entity293 ), 2 with @entity698 complicated with @entity298 , 2 with @entity30773 , one each of left coxitis, infected medial cervical cyst, @entity221 after a V-P shunt operation, purulent @entity8174 and intractable @entity294 with @entity221 , namely, a total of 20 @entity1 aged from one month to 11 years 6 months. A @entity5443 vial which contained 1 g of @entity5443 was used in two ways, i.e., one shot intravenous injection and drip infusion. The dosage of the drug varied from 57 to 121 mg/kg/day and the administration was continued from 2 to 20 days. Clinical effects were evaluated as follows: when cardinal symptoms disappeared within 3 days it was considered to be 'excellent'; within 5 days 'good'; and no change of clinical symptoms within 5 days 'poor'. The bacteriological effect was expressed as 'eliminated', 'unchanged' and 'undetermined'. Clinical efficacy evaluated as 'excellent' occurred in 11 cases, 'good' in 8 cases and 'poor' in 1 case, the efficacy rate being 95.0%. When classified by the disease, the efficacy rate was as follows: 'good' to 'excellent' in 7 out of the 8 cases of @entity1576 , 'excellent' in all of the 3 cases of @entity293 , 'good' and 'excellent' in the 2 cases of @entity30773 and in the 2 cases of @entity298 , 'excellent' in each case of left coxitis, purulent @entity8174 and intractable @entity294 with @entity221 , 'good' in each case of infected medial cervical cyst and @entity221 with a V-P shunt operation. From the bacteriological point of view, 'eliminated' occurred in 5 cases, 'reduced' in 1 case and 'undetermined' in the 2 cases of @entity1576 , 'eliminated' in all of the 3 cases of @entity293 , 'eliminated' in 1 case and 'undetermined' in the 1 case of @entity298 , 'undetermined' in the 2 cases of @entity30773 , 'eliminated' in each case of infected medial cervical cyst and purulent @entity8174 and 'undetermined' in the other cases. Antimicrobial efficacy measured by MIC was compared with CEZ and CET, and the results were as follows: @entity5443 was inferior to the two cephalosporins for @entity794 , it was between CEZ and CET for @entity327 and @entity6747 , and @entity5443 was superior to CEZ and CET for @entity526 . All of the 3 antibiotics had poor antimicrobial efficacy for @entity796 and @entity797 . There were neither clinical side effects nor abnormal laboratory findings which were obviously attributable to @entity5443 during and after administration of the drug.
