Expression of Ki-67, @entity5 suppressor proteins, growth factor, and growth factor receptor in juvenile XXXX : Ki-67 and @entity876 as predictors of aggressive disease.

@entity1 @entity1724 @entity5 @entity310 @entity470 @entity876 @entity1576 @entity995
The enhanced proliferation of epithelial cells is a typical feature of @entity1576 . The mechanism or mechanisms leading to abnormal epithelial proliferation remain unclear. Overexpression of growth factors and their receptors and @entity5 -suppressor proteins are known to cause cell transformation and proliferation. The objectives of this study were to evaluate the expression of these factors in juvenile @entity1576 with correlation to cellular proliferation activity, and to determine whether such expression is associated with the clinical course of the disease. The expression of @entity310 , @entity470 , @entity876 protein, @entity995 proteins and Ki-67 was quantified by immunohistochemistry in paraffin-embedded biopsy specimens taken at the initial surgical excision from @entity1 in whom @entity1724 was diagnosed. Clinical information regarding the number of disease sites, tracheobronchial spread, malignant transformation, and frequency of recurrences was reviewed. Thirty-five specimens were suitable for immunohistochemical evaluation. Ki-67 expression was significantly higher in @entity1 with multiple sites of disease and frequent recurrences. High @entity876 expression was significantly associated with malignant transformation. We concluded that Ki-67 and @entity876 expression may be predictive of the clinical course in @entity1 with @entity1724 .
