Effects of extracts of Salvadora persica on proliferation and viability of XXXX dental pulp stem cells.

@entity1 @entity137 @entity2454
OBJECTIVES: Efficacy of an ideal antimicrobial agent depends on its ability to eliminate microorganisms while causing minimal @entity137 to host cells. The purpose of this study was to assess the effect of ethanolic and water extracts of Salvadora persica (SP) on proliferation and viability of @entity1 dental pulp stem cells (hDPSCs). MATERIALS AND METHODS: In this in-vitro study, the effects of seven concentrations of ethanolic and water extracts of SP (ranging from 5.75 mg/ml to 0.08 mg/ml) on hDPSCs were evaluated using the @entity2454 assay. The results were analyzed using one-way ANOVA and Tukey's post-hoc test. P < 0.05 was considered statistically significant. RESULTS: Water extract of SP only had @entity137 effect at 5.75 mg/ml concentration; and caused significant cell proliferation at 1.43-0.08 mg/ml concentrations at 24 h (P < 0.05). At 48 h, only 0.17 and 0.08 mg/ml concentrations caused significant cell proliferation (P < 0.05). Ethanolic extract of SP at 5.75-1.43 mg/ml concentrations showed severe @entity137 effects at 24 and 48 h. Other concentrations had no significant effects on cells (P > 0.05). CONCLUSION: The highest concentrations of both water and ethanolic extracts of SP had @entity137 effects on hDPSCs. Water extract of SP has favorable effects on cell proliferation at specific concentrations in a time-dependent manner.
