Characteristics and clinical outcome of proximal-third XXXX .

@entity1 @entity17263 @entity5 @entity3 @entity356
BACKGROUND: It is generally accepted that the prognosis of @entity1 with proximal @entity356 (PGC) is worse than that of @entity1 with more @entity356 . STUDY DESIGN: The aim of this study was to compare the clinical features and outcomes of PGC with those of middle- and distal-third @entity356 . A total of 646 primary @entity356 was analyzed as a retrospective study. RESULTS: Proximal @entity356 occurred in 21.8% of the 646 @entity5 analyzed, and approximately 21% of PGCs had esophageal invasion. The 5-year survival rate for @entity1 with PGC was significantly lower than that of @entity1 with more @entity5 . When the PGC group was divided into @entity1 with esophageal invasion and without esophageal invasion, @entity1 with esophageal invasion had significantly worse outcomes. When corrected for depth of invasion, lesions with esophageal invasion had significantly worse outcomes than those of other sites in T2 curative @entity5 . Proximal @entity356 with esophageal invasion was characterized by a larger @entity5 , deeper penetration, and a higher incidence of lymph node @entity3 compared with @entity5 in other sites, and in multivariate analysis of all curative cases, these variables were independent prognostic factors for survival. The frequency of positive proximal margins of @entity17263 was higher than those of other sites. CONCLUSIONS: The relatively poor prognosis associated with PGC is mainly from advanced @entity5 stages of esophageal invasion. Early detection is the most important strategy to improve the survival of @entity1 with PGC. In addition, aggressive lymph node dissection and chemotherapy for esophageal invasion should be considered even if the @entity5 invasion is moderate (T2 @entity5 ), and a @entity5 -free margin is important.
