Altered resting state neuromotor connectivity in @entity1 with chronic prostatitis/chronic XXXX : A MAPP: Research Network Neuroimaging Study.

@entity1 @entity5116 @entity1118 @entity2371
Brain network activity associated with altered motor control in individuals with @entity1118 is not well understood. @entity5116 ( @entity5116 ) is a debilitating condition in which previous studies have revealed altered resting pelvic floor muscle activity in @entity1 with @entity5116 compared to healthy controls. We hypothesized that the brain networks controlling pelvic floor muscles would also show altered resting state function in @entity1 with @entity5116 . Here we describe the results of the first test of this hypothesis focusing on the motor cortical regions, termed pelvic-motor, that can directly activate pelvic floor muscles. A group of @entity1 with @entity5116 (N  =  28), as well as group of age-matched healthy male controls (N  =  27), had resting state functional magnetic resonance imaging scans as part of the Multidisciplinary Approach to the Study of Chronic @entity2371 (MAPP) Research Network study. Brain maps of the functional connectivity of pelvic-motor were compared between groups. A significant group difference was observed in the functional connectivity between pelvic-motor and the right posterior insula. The effect size of this group difference was among the largest effect sizes in functional connectivity between all pairs of 165 anatomically-defined subregions of the brain. Interestingly, many of the atlas region pairs with large effect sizes also involved other subregions of the insular cortices. We conclude that functional connectivity between motor cortex and the posterior insula may be among the most important markers of altered brain function in @entity1 with @entity5116 , and may represent changes in the integration of viscerosensory and motor processing.
