[An etiological and pathologic study of XXXX ].

@entity82 @entity30558 @entity738 @entity4005
OBJECTIVE: To investigate the clinicopathologic characteristics and mechanism of tissue injury caused by @entity4005 ( @entity4005 ) infection. METHODS: Thirty-three cases of @entity30558 in the nasal and pharyngeal region seen in this hospital from Jan. 1980 to Mar. 2000 were studied retrospectively. Warthin-Starry (W-S) stain was used to study all cases. Five cases were studied further with transmission electron microscope. RESULTS: W-S stain revealed a great number of @entity4005 in Mikulicz cells within the @entity738 . Electron microscopy demonstrated a number of phagosomes in the cytoplasm of Mikulicz cells where many @entity4005 were found. A small number of other organelles such as endoplasmic reticulums and lysozymes were squeezed to the side of cells. There were many granular substances on the surface of intracellular bacteria, which were not found on the extracellular @entity4005 . CONCLUSION: @entity4005 is a facultative intracellular bacteria that is able to resist the digestion of macrophages and to proliferate in them. Formation of @entity738 and @entity82 in @entity4005 infiltrated regions is the major cause of tissue injury.
