Ten year follow up of @entity31 XXXX with and without low grade @entity1141 .

@entity1 @entity31 @entity14 @entity1893 @entity258 @entity1141
BACKGROUND AND AIMS: @entity258 ( @entity258 ) is believed to predispose to @entity14 ( @entity14 ), and proctocolectomy has been advocated when this is identified. Between 1978 and 1990, 160 @entity1 with longstanding extensive @entity31 ( @entity31 ) were recruited for annual colonoscopic surveillance and 40 developed @entity258 at some stage. We report the outcome of this cohort 10 years after the original study ended. METHODS: Retrospective cohort study and histopathological review of the original diagnoses of @entity258 . The outcome of 158/160 (98.8%) @entity1 was established in 2000. RESULTS: Of the 128 @entity1 still alive and with an intact colon at the end of 1990, two were not traceable, 29 had @entity258 , and 97 had no @entity1141 (controls). After 10 years, @entity1893 ( @entity1893 ) or @entity14 developed in 3/29 @entity258 (10%) and in 4/97 controls (4.0%). Kaplan-Meier analysis from 1991 to death or colectomy did not show a statistically significant difference between the two groups (log rank test p=0.63). Histopathological review demonstrated the unreliability of @entity258 diagnosis. Agreement between pathologists was uniformly poor: kappa <0.4 for all comparisons. CONCLUSION: @entity258 diagnosis is not sufficiently reliable to justify prophylactic colectomy. Conservative management of established @entity258 cases should not be ruled out.
