Transient release of lipid peroxidation products as a non-invasive marker of successful reperfusion after thrombolysis for XXXX .

@entity1 @entity908 @entity26 @entity1188 @entity4466 @entity880 @entity583 @entity1851
OBJECTIVES: To evaluate an increase in plasma concentration of @entity4466 reactive substances as a non-invasive biochemical test of reperfusion after thrombolysis and to investigate the relation between the inflammatory response after @entity583 and the production of the substances. METHODS: Venous samples were taken from 19 @entity1 receiving thrombolysis for @entity583 before the start of therapy and every hour afterwards up to 5 hours and then at 24 and 48 hours and the concentration of @entity4466 reactive substances measured. These substances are markers of lipid peroxidation induced by free @entity26 radicals. Early reperfusion was judged by regression of ST elevation and late coronary artery patency from the results of coronary angiography 24-72 hours after thrombolysis. RESULTS: The concentration of @entity4466 reactive substances increased in only 6 out of 14 @entity1 with signs of early reperfusion. In @entity1 with late coronary artery patency the corresponding number was 6 out of 15. However, a significant increase in the concentration of @entity4466 reactive substances was found for the whole group 24 and 48 hours after treatment. The change in concentration in serum correlated significantly with that of @entity1851 --an acute phase reactant (r = 0.62, P < 0.01)--but not to the serum activities of markers of @entity1188 size such as @entity908 kinase B and @entity880 dehydrogenase. CONCLUSIONS: The fluorimetric assay used in this study to measure the concentration of @entity4466 reactive substances seems to be an insensitive method of detecting reperfusion after thrombolysis for @entity583 . The increase in concentrations found 24 and 48 hours after treatment correlated with @entity1851 concentrations but not with those of markers of @entity1188 size.
