Pituitary Adenylate Cyclase-Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male XXXX .

@entity19381 @entity146 @entity148 @entity35 @entity31085
BACKGROUND: Severe or prolonged stress can trigger @entity146 illnesses including mood and @entity148 . Recent work indicates that @entity19381 plays an important role in regulating stress effects. In rodents, exogenous @entity19381 administration can produce persistent elevations in the acoustic startle response, which may reflect @entity148 -like signs including hypervigilance. We investigated whether @entity19381 causes acute or persistent alterations in behaviors that reflect other core features of mood and @entity148 (motivation, social interaction, and attention). METHODS: Using male @entity35 , we examined if @entity19381 (.25-1.0   g, intracerebroventricular infusion) affects motivation as measured in the intracranial self-stimulation test. We also examined if @entity19381 alters interactions with a conspecific in the social interaction test. Finally, we examined if @entity19381 affects performance in the 5-choice serial reaction time task, which quantifies attention and error processing. RESULTS: Dose-dependent disruptions in motivation, social interaction, and attention were produced by @entity19381 , as reflected by increases in reward thresholds, decreases in social behaviors, and decreases in correct responses and alterations in posterror accuracy. Behavior normalized quickly in the intracranial self-stimulation and 5-choice serial reaction time task tests but remained dysregulated in the social interaction test. Effects on attention were attenuated by the corticotropin-releasing factor receptor-1 antagonist @entity31085 but not the k opioid receptor antagonist JDTic. CONCLUSIONS: Our findings suggest that @entity19381 affects numerous domains often dysregulated in mood and @entity148 , but that individual signs depend on brain substrates that are at least partially independent. This work may help to devise therapeutics that mitigate specific signs of these disorders.
