A study of the efficacy of topical and systemic therapy for the treatment of feline @entity14476 XXXX .

@entity1216 @entity5897 @entity3101 @entity281 @entity468 @entity14476
@entity14476 @entity281 was induced in 21 healthy SPF-derived @entity468 . Once @entity281 was established (4 weeks after inoculation) the @entity468 were divided into three equal groups housed in separate rooms and monitored for 16 weeks. During this time, group A @entity468 received oral @entity3101 at approximately 50 mg/kg daily and were shampooed twice weekly with a product containing @entity1216 and @entity5897 . Group B @entity468 were treated with @entity3101 alone, and group C @entity468 served as untreated controls. The @entity468 were examined on a weekly basis and the severity of lesions was scored semi-quantitatively. In addition, hair samples were collected from each cat on a weekly basis by the MacKenzie brush technique and by the sticky-tape method. A semi-quantitative scoring system was also used for the assessment of fungal ( @entity14476 ) growth. Generally, significant differences in clinical scores were not seen between the groups although at weeks 3, 4 and 11 there was a significant difference (P< or =0.015) with @entity468 in group A having significantly lower median scores than those in group C. Median times to clinical resolution (return of clinical scores to zero) in groups A, B and C were at treatment weeks 2, 9 and 12, respectively (P>0.05). Median times for mycological resolution (persistently negative culture results) for groups A, B and C were at treatment weeks 2, 9 and 12, respectively, for the MacKenzie brush technique and at weeks 4, 8 and 12 for the sticky-tape technique. For both these results, the groups differed significantly (P< or =0.001) and in both instances group A had significantly more rapid resolution than groups B or C. Median culture scores were significantly different between the three groups using one or both of the sampling techniques at week 2 through to week 12 of treatment with median scores for either group A alone, or groups A and B being significantly lower than group C (P< or =0.026). These results showed a benefit from the addition of twice-weekly @entity1216 - @entity5897 shampooing to systemic @entity3101 therapy alone in the treatment of @entity14476 infected @entity468 .
