The impact of surgery for XXXX upon health-related quality of life and pelvic floor outcomes during the first year of treatment: a longitudinal, mixed methods study.

@entity5 @entity1 @entity158
OBJECTIVE: To measure the long-term impact of surgical treatment for @entity5 upon health-related quality of life and pelvic floor outcomes during the first year of therapy. METHODS: Prospective, longitudinal, mixed-methods study. Twenty-three @entity1 aged >18  years with a new diagnosis of @entity5 were recruited. The EORTC QLQ C30, SF-36 and an electronic pelvic floor assessment questionnaire (ePAQ-PF) were administered at baseline (pre-treatment) and 3, 6, 9 and 12  months post-treatment. Mixed effects repeated measures models (all adjusted for age and BMI) were used to investigate changes over time and differences between @entity5 stage. Qualitative interviews were carried out with 11 of the @entity1 and analysed using a thematic approach. RESULTS: Mean age was 59.9  years (SD   =   15.3; range   =   23.8-86.6  yrs). Mean BMI was 30.0 (SD   =   4.5; range   =   24.4-38.2). Sixteen @entity1 had early (Stage 1 to 2B), and seven @entity1 had advanced stage disease (Stage 3 to 4B). Questionnaire scores revealed that physical and social functioning, fatigue, @entity158 and general sex life were significantly worse at 12  months than pre-treatment (p   =   < 0.05). Qualitative analysis revealed multiple treatment side effects which were perceived as severe and enduring. @entity1 with advanced @entity5 had significantly worse SF-36 mental health scores at 12  months compared to @entity1 with early stage disease (p   =   0.037). CONCLUSIONS: Surgery for @entity5 has long-term implications which can be persistent 12  months post-treatment. High rates of morbidity relating to lymphoedema and sexual function re-enforce the need for specialist clinics to support @entity1 who suffer these complications.    2015 The Authors. Psycho-Oncology published by John Wiley _ Sons Ltd.
