Persistent behavioral effects following early life exposure to @entity1968 or XXXX in @entity3392 .

@entity3570 @entity1 @entity6100 @entity1092 @entity3457 @entity10204 @entity600 @entity8853 @entity601 @entity1968 @entity427 @entity3392 @entity554
BACKGROUND: Moderate to severe @entity10204 in @entity554 signaling during early development is associated with a constellation of physical @entity601 , including @entity3570 . It is thought that more subtle @entity10204 of this system, which might be achievable via dietary (i.e. @entity8853 ) or pharmacological (i.e. @entity1092 ) exposure in @entity1 , will manifest on behavioral domains including sociability, without overt physical abnormalities. METHODS: During early life, @entity3392 were exposed to low doses of two chemicals that disrupt @entity554 signaling. From 0 to 5dpf, larvae were reared in aqueous solutions containing @entity1968 (0, 0.02, 0.2 or 2nM) or @entity1092 (0, 0.5, 5.0 or 50 M). One cohort of @entity3392 was assessed using a locomotor activity screen at 6-dpf; another was reared to adulthood and assessed using a neurobehavioral test battery ( @entity427 , novel tank exploration, shoaling, and predator escape/avoidance). RESULTS: There was no significant increase in the incidence of physical @entity600 among exposed fish compared to controls. Both @entity1968 and @entity1092 exposures during development disrupted @entity3457 with persisting behavioral alterations later in life, primarily manifesting as @entity6100 . CONCLUSIONS: Social behavior and some aspects of motor function were altered in exposed fish; the importance of examining emotional or psychological consequences of early life exposure to @entity554 acting chemicals is discussed.
