Acute increase in plasma D-dimer level in XXXX : an experimental study.

@entity43 @entity1 @entity35 @entity63
BACKGROUND: Torsion of the ovary is a rare but serious cause of gynecologic surgical emergency. Specific laboratory markers that support the preoperative diagnosis of @entity43 are not currently available in the clinical routine. The aim of this study was to investigate the diagnostic value of plasma D-dimer level as an early indicator of @entity43 in an experimental @entity35 @entity43 model. METHODS: Sixteen female adult @entity35 were used for this controlled experimental study. Eight @entity35 in the sham operation group (Group I) underwent a surgical procedure similar to Group II but the ovary was not occluded. In Group II (eight @entity35 ), a torsion model was created by using atraumatic vascular clips just above and below the right ovary for a 2-h period of @entity63 . Right ovaries were surgically removed at the end of the procedure in each group. Blood was sampled before and after operation to assess plasma D-dimer levels. The main outcome measure was ovarian histopathologic findings scores and plasma D-dimer levels. RESULTS: There was no significant difference in pre-operative plasma D-dimer levels (0.5963    0.2047 mg/l in Group I, 0.6344    0.1348 mg/l in Group II, P = 0.815, Mann-Whitney U-test). However, mean plasma D-dimer value for Group II was significantly higher than that in the control group (1.2267    0.3099 versus 0.6213    0.2346 mg/l, respectively, Mann-Whitney U-test, P < 0.001), following 2 h of @entity43 . Ovarian tissue damage scores were also statistically significantly different among groups. CONCLUSIONS: If the observations made in a @entity35 model are extended to @entity1 , plasma D-dimer measurement may be a valuable parameter in the early diagnosis of @entity43 .
