Measurement of effective pulmonary capillary pressure using the pressure profile after pulmonary XXXX .

@entity1 @entity3126 @entity235 @entity649 @entity120 @entity358 @entity72336 @entity750 @entity112 @entity432
Pulmonary artery catheters are frequently used to measure @entity358 , particularly the pulmonary wedge pressure (Pw), which reflects pulmonary venous and ideally left atrial pressures. However, the pulmonary capillary pressure (Pc) is the major force in the formation of @entity3126 . Unfortunately, Pw has been interpreted as being identical to Pc. In this study we used 7-Fr pulmonary artery catheters to measure effective Pc in closed-chest animals and @entity1 . The decreasing pressure profile after pulmonary @entity432 was separated into fast and slow components, with the inflection point between them representing Pc. Pc was also estimated by mathematically analyzing the curves in terms of a precapillary resistance, a large pulmonary capillary capacitor, and a postcapillary resistance. In @entity235 , Pc was determined after pulmonary vascular resistance had been increased by infusing @entity750 and @entity112 . While Pw remained unchanged, @entity750 increased pulmonary artery pressure (Ppa) 52% and @entity72336 %, whereas @entity112 increased Ppa only 25%, but increased Pc by 35%. This is consistent with studies showing that @entity750 primarily elevates precapillary resistance, and @entity112 increases postcapillary resistance. In thoracic surgery @entity1 , Pc was not consistently related to Pw. This measurement was simple, reproducible, and provided a more precise capillary filtration pressure than Pw. It should be clinically useful in monitoring @entity1 with @entity120 and adult @entity649 , especially those with pulmonary artery catheters.
