Morphometric MRI alterations and postoperative @entity410 control in refractory XXXX .

@entity1 @entity410 @entity131 @entity1315 @entity194 @entity302 @entity21 @entity62
UNASSIGNED: Refractory mesial @entity1315 (mTLE) is a debilitating condition potentially amenable to resective surgery. However, between 40 and 50% @entity1 continue to experience @entity410 . The development of imaging prognostic markers of postoperative @entity410 outcome is a crucial objective for @entity302 research. In the present study, we performed analyses of preoperative cortical thickness and subcortical surface shape on MRI in 115 of @entity1 with mTLE and radiologically defined @entity131 being considered for surgery, and 80 healthy controls. @entity1 with excellent (International League Against @entity302 outcome (ILAE) I) and suboptimal (ILAE II-VI) postoperative outcomes had a comparable distribution of preoperative @entity21 . Conventional volumetry of whole hippocampal and extrahippocampal @entity62 , could not differentiate between @entity1 outcome groups. However, surface shape analysis revealed localized atrophy of the thalamus bilaterally and of the posterior/lateral hippocampus contralateral to intended resection in @entity1 with persistent @entity410 relative to those rendered @entity410 free. Data uncorrected for multiple comparisons also revealed @entity194 of the ipsilateral hippocampus posterior to the margins of resection in @entity1 with persistent @entity410 . This data indicates that persistent @entity410 after temporal lobe surgery are related to localized preoperative shape alterations of the thalamus bilaterally and the hippocampus contralateral to intended resection. Imaging techniques that have the potential to unlock prognostic markers of postoperative outcome in individual @entity1 should focus assessment on a bihemispheric thalamohippocampal network in prospective @entity1 with refractory mTLE being considered for temporal lobe surgery. Hum Brain Mapp, 2014.    2014 The Authors @entity1 Brain Mapping Published by Wiley Periodicals, Inc.
