Epidemiology of XXXX due to extended-spectrum Beta-lactamase-producing bacteria in a pediatric intensive care unit.

@entity1 @entity3524 @entity281 @entity25323 @entity4005 @entity5505 @entity526
OBJECTIVES: To determine the proportion of @entity281 caused by extended-spectrum   -lactamase ( @entity25323 )-producing @entity4005 or @entity526 Gram-negative organisms in the pediatric intensive care unit (PICU), and to identify risk factors for these @entity281 . METHODS: A retrospective, single-center chart review of @entity1 admitted to a PICU in a 5-year period with @entity281 caused by @entity4005 species or @entity526 was completed. Data collected include demographics, length of stay, outcome, and relevant risk factors previously defined in the literature. RESULTS: A total of 110 isolates were cultured from 94 @entity1 . A total of 53% of the isolates were @entity526 , and the remainder were @entity4005 subspecies. Of the 110 isolates, 13 isolates (11.8%) in 7 @entity1 were @entity25323 positive. The @entity25323 -producing isolates were equally distributed amongE coli and @entity4005 and were primarily cultured from tracheal aspirates. Most of the @entity25323 -positive isolates (9 of 13; 69%) were cultured from @entity1 who received @entity5505 and/or @entity3524 in the preceding 30 days. @entity1 infected with @entity526 had higher PRISM 1 scores and were more likely to have a Foley catheter, whereas @entity4005 were more common in mechanically ventilated males. Although not statistically significant, 80% of @entity1 who were infected with non- @entity25323 -producing organisms survived to hospital discharge versus 57% of those infected with @entity25323 -producing @entity526 and @entity4005 . CONCLUSIONS: Almost 12% of @entity526 and @entity4005 isolates in this @entity1 population tested positive for @entity25323 production. @entity25323 production was equally distributed between @entity526 and @entity4005 species. These organisms were cultured from 7% of the study @entity1 . As reported in previous studies, @entity1 infected with @entity25323 -producing organisms most often had received prior cephalosporins and had a longer length of stay in the PICU.
