Complications of combined radiation therapy and surgery for XXXX and inferior hypopharynx.

@entity1 @entity5 @entity189 @entity281 @entity292 @entity204 @entity12391
A group of 554 @entity1 was studied to determine and compare the complications of combined preoperative radiation therapy with surgery and combined surgery with postoperative radiation therapy when used for treatment of @entity189 and inferior hypopharynx. The complications recorded were @entity281 , slough, carotid blowout, glottic insufficiency, pharyngeal stricture, @entity204 , @entity12391 , @entity292 , and margins of resection involved with @entity5 . The highest complication rates were in the partial laryngopharyngectomy-postoperative radiation group (63.6%) and in the supraglottic laryngectomy-postoperative radiation group (52.9%). Most of the increase in total complication rate was attributable to higher rates of glottic insufficiency and margins involved with @entity5 categories. The lowest complication rates were in the hemilaryngectomy with no radiation group (4.5%) and the total laryngectomy-postoperative radiation group (12.8%). The complication rate for the supraglottic laryngectomy-postoperative radiation group (52.9%) was significantly higher than for the preoperative radiation-supraglottic laryngectomy group (26.4%). Within the partial laryngopharyngectomy group, there was no significant difference in total complication rate between the use of preoperative (47.2%) or postoperative radiation (63.6%). Within the total laryngectomy group there was no significant difference between complication rates when either preoperative or postoperative radiation was employed. There was no significant difference in the rate of carotid blowout, @entity12391 , @entity204 , slough, or @entity292 , between preoperative or postoperative radiation in any of the surgical groups. In general, @entity1 with conservation surgery seem to tolerate postoperative radiation without a prohibitive increase in complications.
