Control of XXXX growth by @entity2764 restriction or treatment with an antivitamin agent.

@entity2764 @entity5 @entity35 @entity157 @entity71307
The growth of 9A and 7316A Morris @entity157 was studied in @entity2764 (PN)-depleted and in pair-fed control @entity35 . @entity35 groups were fed the respective diets for 3 weeks, inoculated with 9A and 7316A @entity5 cells in both hind leg muscles, and killed after 21 and 41 days respectively. Another group was fed ad lib the PN-sufficient diet and similarly inoculated with 7777 @entity157 cells. In this instance @entity5 were let grow maximally to the extent that @entity35 were practically unable to move and feed themselves. At this time ten animals were treated with @entity71307 every other day for 9 days, leaving five (untreated) @entity35 as controls. @entity35 pair-fed the PN-sufficient diet developed significantly heavier 9A and 7316A @entity157 with P less than or equal to 0.005 and P less than 0.001 significance levels, respectively. Treatment with the antivitamin agent extended significantly animal life span. Six @entity35 lived for 8 days, three for 12, and one for 18 days. Four of the untreated @entity35 died within 3 days, the fifth on the 8th day. These results demonstrate that PN restriction causes significant @entity5 weight and its in situ inactivation in vivo significantly extends the life of the @entity5 bearing animals.
