Effects of high-intensity training on indices of ventilatory efficiency in chronic XXXX .

@entity1 @entity26 @entity712 @entity544
BACKGROUND: Measures of ventilatory inefficiency, such as the slope of the relation between ventilation and @entity544 production ((Equation is included in full-text article.)slope) and the @entity26 uptake efficiency slope (OUES) have recently been shown to be strong prognostic markers in @entity1 with @entity712 . Little is known regarding the effects of exercise training on these indices. METHODS: Fifty @entity712 @entity1 (mean age = 55    6 years, ejection fraction = 33    6%) referred to a residential cardiac rehabilitation program were randomized to a 2-month high-intensity training program (n = 24) or to a control group (n = 26). Before and after the study period, maximal cardiopulmonary exercise testing was performed, and markers of ventilatory inefficiency were determined. RESULTS: Training increased peak @entity26 uptake ((Equation is included in full-text article.); 23%), exercise time (29%), and peak workload (28%), whereas no changes were observed in controls (all P < .05 between groups). No differences were observed in the (Equation is included in full-text article.)slope in either group. However, the ventilatory equivalent for @entity26 ((Equation is included in full-text article.)ratio) was reduced at matched work rates throughout exercise (P < .01). The OUES increased by 12% in the exercise groups (P = .003) and 4% in controls. At baseline, trained @entity1 had an OUES that was 69% of the age-predicted value and this improved to 78% after training (P = .004). The change in OUES was significantly related to the change in peak (Equation is included in full-text article.)with training (r = 0.63, P = .001). CONCLUSION: High-intensity training resulted in marked improvements in exercise capacity in @entity1 with @entity712 . Training improved the OUES and reduced the (Equation is included in full-text article.)ratio, but the (Equation is included in full-text article.)slope was unchanged. Among measures of ventilatory inefficiency, the OUES may be more sensitive to training than the (Equation is included in full-text article.)slope.
