Metabolic engineering for the production of plant XXXX .

@entity23386 @entity11545 @entity40873 @entity1286 @entity3812 @entity8075
UNASSIGNED: Several plant @entity23386 (PIAs) possess powerful pharmaceutical and biotechnological properties. Thus, @entity8075 metabolism and its fascinating molecules, including @entity1286 , @entity3812 and @entity11545 , have attracted the attention of both the industry and researchers involved in plant science, biochemistry, chemical bioengineering and medicine. Currently, access and availability of high-value PIAs [commercialized (e.g. @entity11545 ) or not (e.g. @entity40873 )] is limited by low concentration in nature, lack of cultivation or geographic access, seasonal production and risk of overharvesting wild plant species. Nevertheless, most commercial PIAs are still extracted from plant sources. Efforts to improve the production of @entity8075 have largely been impaired by the lack of knowledge on @entity8075 metabolism. With the development and integration of next-generation sequencing technologies, high-throughput proteomics and metabolomics analyses and bioinformatics, systems biology was used to unravel metabolic pathways allowing the use of metabolic engineering and synthetic biology approaches to increase production of valuable PIAs. Metabolic engineering provides opportunity to overcome issues related to restricted availability, diversification and productivity of plant alkaloids. Engineered plant, plant cells and microbial cell cultures can act as biofactories by offering their metabolic machinery for the purpose of optimizing the conditions and increasing the productivity of a specific alkaloid. In this article, is presented an update on the production of @entity8075 in engineered plant, plant cell cultures and heterologous micro-organisms.
