Early-stage XXXX : long-term results with radiotherapy alone or combined radiotherapy and chemotherapy.

@entity1 @entity1375 @entity137 @entity82 @entity4557 @entity5 @entity3052 @entity978 @entity4685
BACKGROUND: Controversy still exists over the optimal management of early-stage @entity978 ( @entity978 ); presentation features may have a different prognostic impact according to initial therapy, and long-term @entity137 must be fully evaluated. @entity1 AND METHODS: This study included 164 @entity1 with stage IA-IIA @entity978 treated with radiotherapy (RT) alone or combined radio- and chemotherapy (CT) according to presenting features and their attendant prognostic significance. The RT group included 88 @entity1 with favorable prognostic features; the combined modality group included 76 @entity1 with one or more unfavorable features. In the RT group, 85% of @entity1 received extended-mantle or STNI; in the combined modality group, RT consisted of mantle- (49%), extended mantle- (37%), and involved-field irradiation (14%); CT consisted of 6 cycles of MOPP before 1984; 3 cycles of ABVD were substituted for MOPP thereafter. RESULTS: Complete remission was obtained in 94% and 99% of @entity1 of the RT and combined modality groups, respectively. The 10-year actuarial @entity4557 ( @entity4557 ) in the RT group was 62% and was influenced by stage (p = 0.04) and histology (p = 0.01); in the combined modality group, @entity4557 was 88% and was influenced by the presence of bulky disease. Overall survival and @entity5 mortality between the therapy groups were comparable. RT-related @entity137 consisted of mediastinal @entity82 (8 cases), @entity4685 (3), @entity1375 (2); other long-term events included 2 cases of @entity3052 in the combined MOPP and RT group. Altogether, 8 of 20 @entity1 who died were in their first complete remission. CONCLUSIONS: In stage IA-IIA @entity978 , the combined modality therapy reduced the risk of relapse compared to radiation alone; long-term @entity137 of RT was not negligible and relapses could occur late.
