Senescent change in tissue weight and immunoreactive @entity11982 , XXXX , and vasopressin in eight regions of C57BL/6J @entity19 brain and pituitary.

@entity11982 @entity19 @entity3239 @entity2339 @entity3000
Tissue weights and immunoreactive (IR) content and concentration of @entity11982 , @entity3000 , and vasopressin were assayed for senescent change in anterior pituitary, neurointermediate pituitary, @entity2339 , hippocampus, striatum, dorsolateral cortex, and pons-medulla, as well as residual brain samples remaining after the other dissections. Groups of naive male C57BL/6J @entity19 , 8-12 months old and 28-32 months old, served as subjects. Old @entity19 exhibited significant decline in anterior pituitary and hippocampus weight. Significant increases with age were found in pons-medulla weight. @entity3239 -endorphin content decreased in @entity2339 and neurointermediate pituitary. IR @entity3000 decreased in striatum and dorsolateral cortex. IR vasopressin content increased in @entity2339 and residual brain. Assays were replicated in later experiments using additional subjects, for total Ns of up to 54 @entity19 . Although significant overall results were always consistent in direction from replication to replication, the magnitude of age change exhibited considerable variability. Such results suggest that single experiments on age changes in neuropeptides, particularly those giving negative results, should be carefully scrutinized and replicated before their acceptance as evidence for a transmitter's stability or instability throughout the lifespan.
