A @entity6069 mutation, high breast density and prominent pushing margins of a XXXX independently contribute to a frequent false-negative mammography.

@entity1 @entity0 @entity5345 @entity5 @entity6069
Female @entity6069 mutation carriers develop in up to 50% @entity0 ( @entity0 ) before age 50 years. We investigated whether the specific histologic features of @entity5345 /2-associated @entity0 influence imaging. We correlated the mammographic results with the histology of 34 @entity0 in @entity6069 mutation carriers and 34 @entity5 in @entity1 , matched for age and year of diagnosis. Mammography was significantly more frequently false-negative in carriers than controls (62% vs. 29% p = 0.01), despite comparable @entity5 size (mean solidus in circle 1.51 vs. 1.75) and breast density (high 41% vs. 53%). The image in carriers was significantly less as spiculated mass (6 vs. 18 p = 0.01). Cancers of @entity5345 /2 mutation carriers had frequently higher mitotic counts (p < 0.0001) and prominent pushing margins around the @entity5 (p = 0.08) (p = 0.05 for 32 @entity5345 ). We also observed that prominent "pushing margins" correlated significantly with a false-negative mammography (p = 0.005) and with a mammographic image of a smooth, not a spiculated, mass (p = 0.01). False-negative mammography correlated independently with: @entity5345 /2 mutation (p = 0.02), prominent pushing margins (p = 0.03) and high breast density (p = 0.01). MRI was carried out in 12 carriers, had 100% sensitivity and detected 5 @entity5 , still occult at physical examination and mammography. A @entity5345 /2 mutation and high breast density at mammography contribute independently to false-negative mammography results. In mutation carriers any mammographic mass must be regarded with suspicion. Pushing margins of the @entity5 partly explain these results. For early @entity0 detection in mutation carriers additional methods like MRI may be needed. This may not be necessary in other young @entity1 with breast symptoms.
