Prevalence of abnormal lipid profiles and the relationship with the development of microalbuminuria in adolescents with type 1 XXXX .

@entity3916 @entity6 @entity2316 @entity14822 @entity1011 @entity165
OBJECTIVE: To explore the prevalence of @entity14822 and their relationship with albumin excretion and microalbuminuria in adolescents with type 1 @entity6 . RESEARCH DESIGN AND METHODS: The study population comprised 895 young subjects with type 1 @entity6 (490 males); median age at the baseline assessment was 14.5 years (range 10-21.1), and median @entity6 duration was 4.8 years (0.2-17). A total of 2,194 nonfasting blood samples were collected longitudinally for determination of total @entity165 , LDL @entity165 , HDL @entity165 , TG, and non-HDL @entity165 . Additional annually collected data on anthropometric parameters, @entity3916 , and albumin-to- @entity1011 ratio (ACR) were available. RESULTS: Total @entity165 , LDL @entity165 , HDL @entity165 , and non-HDL @entity165 were higher in females than in males (all P < 0.001). A significant proportion of subjects presented sustained @entity14822 during follow-up: total @entity165 >5.2 mmol/l (18.6%), non-HDL @entity165 >3.4 mmol/l (25.9%), TG >1.7 mmol/l (20.1%), and LDL @entity165 >3.4 mmol/l (9.6%). Age and duration were significantly related to all lipid parameters (P < 0.001); @entity3916 was independently related to all parameters (P < 0.001) except HDL @entity165 , whereas BMI SD scores were related to all parameters (P < 0.05) except total @entity165 . Total @entity165 and non-HDL @entity165 were independently related to longitudinal changes in ACR (B coefficient +/- SE): 0.03 +/- 0.01/1 mmol/l, P = 0.009, and 0.32 +/- 0.014/1 mmol/l, P = 0.02, respectively. Overall mean total @entity165 and non-HDL @entity165 were higher in microalbuminuria positive (n = 115) than in normoalbuminuric subjects (n = 780): total @entity165 4.7 +/- 1.2 vs. 4.5 +/- 0.8 mmol/l (P = 0.04) and non-HDL @entity165 3.2 +/- 1.2 vs. 2.9 +/- 0.8 mmol/l (P = 0.03). CONCLUSIONS: In this longitudinal study of adolescents with type 1 @entity6 , sustained @entity14822 were related to age, duration, BMI, and @entity3916 . Furthermore, ACR was related to both total @entity165 and non-HDL @entity165 , indicating a potential role in the pathogenesis of @entity2316 .
