Mite component-specific IgE repertoire and phenotypes of XXXX in childhood: the tropical perspective.

@entity1 @entity483 @entity2023 @entity7130 @entity565 @entity56
Sensitization to perennial aeroallergens correlates with the risk of persistent @entity565 ( @entity565 ) in @entity1 . In tropical Singapore, multiple codominant species of mites abound in the indoor environment, and preferential species-specific sensitization has been associated with different phenotypes of @entity56 . We investigated the pattern of mite component-specific IgE (mcsIgE) in @entity1 with different phenotypes of @entity56 in an environment with multiple mite species exposure. A prospective evaluation of newly diagnosed @entity1 with clinical diagnosis of @entity2023 ( @entity2023 ), @entity483 ( @entity483 ), or @entity565 and sensitization to one or more aeroallergens were performed. Sera were tested for specific IgE against an extensive panel of @entity7130 and Blomia tropicalis allergens. A total of 253 @entity1 were included, mean age 7.3 yr, 79% fulfilled criteria for @entity2023 , 46% @entity565 , 71% @entity483 , and 31% for all three. Sensitization to one or both mites was observed in 91% of @entity1 , 89% were sensitized to @entity7130 , and 70% to B. tropicalis. The most common mite allergens recognized by these atopic @entity1 were Der p 1 (64%), Der p 2 (71%), Blo t 5 (45%), Blo t 7 (44%), and Blo t 21 (56%). Specific IgE responses to an increased number of distinct mite allergens correlated with the complexity of the @entity56 phenotype. In multivariate analysis, an increased risk for the multi-systemic phenotype ( @entity2023 + @entity565 + @entity483 ) was associated with sensitization to an increased repertoire of mite components (three or more) (OR 4.3, 95% CI 2.1-8.8, p = 0.001) and a positive parental history of @entity565 (OR 2.4, 95% CI 1.2-2.9, p = 0.013). A highly pleiomorphic IgE response to the prevalent indoor mites is associated with the presence of a multi-systemic @entity56 phenotype in childhood in a tropical environment.
