Second Surgery in Insular XXXX .

@entity1 @entity5 @entity11 @entity818 @entity3271
Background. Given the technical difficulties, a limited number of works have been published on @entity11 surgery and risk factors for @entity5 recurrence (TR) are poorly documented. Objective. The aim of the study was to determine TR in adult @entity1 with initial diagnosis of insular @entity11 ( @entity11 ) that subsequently underwent second surgery. Methods. A consecutive series of 53 @entity1 with insular @entity11 was retrospectively reviewed; 23 @entity1 had two operations for TR. Results. At the time of second surgery, almost half of the @entity1 had experienced progression into high-grade @entity11 (HGGs). Univariate analysis showed that TR is influenced by the following: extent of resection (EOR) (P < 0.002),   VT2T1 value (P < 0.001), histological diagnosis of @entity3271 (P = 0.017), and mutation of @entity818 (P = 0.022). The multivariate analysis showed that EOR at first surgery was the independent predictor for TR (P < 0.001). Conclusions. In @entity1 with insular LGG the EOR at first surgery represents the major predictive factor for TR. At time of TR, more than 50% of cases had progressed in HGG, raising the question of the oncological management after the first surgery.
