Preliminary results of treatment of invasive @entity150 with radiotherapy and XXXX .

@entity1 @entity66 @entity41 @entity1494 @entity5 @entity900 @entity54060 @entity150
From October 1985 to February 1988, 41 @entity1 with @entity150 were treated with transurethral resection (TUR) and radiotherapy with simultaneous @entity900 chemotherapy at the University Hospital in Erlangen. Radiotherapy was performed as primary treatment in case of macroscopic @entity41 after TUR (n = 22) or as adjuvant treatment in @entity1 with macroscopically complete transurethral resection (n = 19). Age ranged from 44 to 77 years. Radiotherapy was given in daily fractions of 1.8 Gy. The pelvis was treated with a box up to 41.4 Gy and the bladder was boosted up to 50.4 Gy by a rotation technique. @entity900 was administered in the first and fifth treatment week on five consecutive days with 25 mg @entity900 /m2 per day as short infusion. Pathohistologic response was examined by control cystoscopy with biopsies from the deep layers 6 weeks after completing radiochemotherapy. Maximum follow-up is 24 months after control cystoscopy. After TUR plus radiochemotherapy, histologically confirmed complete remission rates according to T-stage were: 7/8 T1-, 26/31 T2-3-, and 2/2 T4- @entity5 . In @entity1 with macroscopic @entity5 prior to radiochemotherapy, histological and cytological complete remission was achieved in 2/ @entity54060 -, 14/18 T2-3-, and 1/1 T4-cancers with an overall complete response rate of 77%. In complete responders, 3 isolated local recurrences (2 T1- and one T3-recurrence) and two local recurrences with distant metastases have occurred until now. Six @entity1 had only partial response. Mild to moderate side effects occurred frequently, but overall treatment tolerance was good even in older @entity1 . Complications did not occur. So far, 7 cystectomies have been performed, 6 were a result of persistent or recurrent @entity5 and one a result of a @entity1494 after multiple TURs. Thirty-four of forty-one @entity1 (83%!) maintained their bladder and normal bladder function. In conclusion, moderate dose radiation therapy (50 Gy) in combination with simultaneous @entity900 chemotherapy is a well-tolerated treatment and highly effective for controlling @entity66 and preservation of bladder function in @entity150 .
