[Relationship between the efficacy of inhaled corticosteroids and the leukotriene expression in @entity1 with XXXX ].

@entity1 @entity565 @entity21238 @entity11130
OBJECTIVE: To evaluate the relationship between leukotriene expression in blood polymorphonuclear leukocytes (PMNL) and the efficacy of inhaled corticosteroids (ICS) in @entity1 with @entity565 . METHODS: Thirty-two @entity1 with @entity565 (5-12 years) and ten healthy @entity1 (control group) were enrolled. The asthmatic @entity1 were subdivided into ICS well-controlled and ICS poorly-controlled groups based on their clinical symptoms and lung function. The level of @entity21238 ( @entity21238 ) mRNA in PMNL was detected by fluorescence quantitative polymerase chain reaction. The level of @entity21238 mRNA was expressed by the value of qCt, and the value of qCt was diversely correlated with the level of @entity21238 mRNA expression. The concentration of urinary @entity11130 (LTE4) was measured using ELISA. RESULTS: The expression of @entity21238 mRNA in PMNL was significantly higher in @entity1 with @entity565 (qCt: 1.12+/-0.27) than that in the control group (qCt: 1.42+/-0.12; P< 0.05). The expression of @entity21238 mRNA in PMNL in the ICS poorly-controlled group (qCt: 1.03+/-0.17) was significantly higher than that in the ICS well-controlled group (qCt: 1.24+/-0.33; P< 0.05) and the control group(1.42+/-0.12; P< 0.01). There was no significant difference in the level of urinary LTE4 among the the ICS poorly-controlled, the ICS well-controlled and the control groups. CONCLUSIONS: @entity21238 mRNA expression in PMNL in asthmatic @entity1 increases, and the @entity21238 mRNA expression in the ICS poorly-controlled group is higher than that in the ICS well-controlled group. This suggests that an increased leukotriene expression might be associated with poorly-controlled @entity565 .
