Sex, Adiposity, and @entity101 Status Modify the Inverse Effect of Marine Food Intake on Blood Pressure in Alaska Native (Yup'ik) XXXX .

@entity1 @entity7784 @entity1568 @entity101 @entity4600 @entity1144 @entity551 @entity13140
BACKGROUND: Alaska Native @entity1 currently have a higher prevalence of @entity101 than do nonnative Alaskans, although in the 1950s @entity101 was rare among Alaska Native @entity1 . A novel biomarker of marine foods, the @entity1568 isotope ratio (  @entity13140 ) in RBCs was shown to be negatively associated with @entity551 . Few studies have examined how individual characteristics modify the association of marine food intake with blood pressure. OBJECTIVE: This exploratory analysis examines whether sex, adiposity, and @entity101 modify the inverse association between marine food intake and blood pressure. METHODS: We used covariate-adjusted linear models to describe the association between   @entity13140 and blood pressure in 873 adult Alaska Native (Yup'ik) @entity1 who resided in 8 communities in southwest Alaska. We separately stratified by sex, body mass index (BMI) group, @entity1144 , and @entity101 status and assessed the interaction between   @entity13140 and @entity1 characteristics on blood pressure via likelihood ratio tests. RESULTS: The association between   @entity13140 and systolic blood pressure was modified by sex, BMI status, and @entity1144 , with the inverse association observed only in the male (b = -1.5; 95% CI: -2.4, -0.6 : , nonobese BMI (b = -1.7; 95% CI: -2.5, -1.0), and @entity1144 (b = -1.6; 95% CI: -2.4, -0.9) strata (all P-interaction < 0.0001). A reduction in diastolic blood pressure associated with   @entity13140 was observed in the nonobese BMI (b = -1.1; 95% CI: -1.7, -0.5) and @entity1144 (b = -1.1; 95% CI: -1.7, -0.5) strata, although only the interaction between BMI group and   @entity13140 with diastolic blood pressure was significant. The inverse association between   @entity13140 and both @entity551 was observed in nonhypertensive individuals, although the comparison had limited power. The results were consistent with those identified by using combined RBC concentrations of @entity7784 and @entity4600 as the biomarker of marine food intake, although the associations identified by using   @entity13140 were larger. CONCLUSIONS: Obesity status modified the inverse association between marine food intake and both @entity551 in adult Alaska Native (Yup'ik) @entity1 . The inverse association between   @entity13140 and systolic blood pressure was also modified by sex.
