The comparative efficacy of drug therapies used for the management of corticosteroid-induced XXXX : a meta-regression.

@entity1 @entity175 @entity1568 @entity171 @entity170 @entity79 @entity460 @entity1388 @entity560
We determined the comparative efficacy of @entity560 , @entity175 , @entity1388 , and @entity171 for the management of corticosteroid-induced @entity170 using meta-regression models. A systematic search for trials was conducted using MEDLINE, bibliographic references, abstracts from national meetings, and contact with pharmaceutical companies and content experts. We included all randomized controlled trials, lasting at least 6 months, of adult @entity1 on oral corticosteroids that evaluated treatment comparisons between @entity560 , @entity175 , @entity171 , or @entity1388 either with no therapy/ @entity460 or with each other and that reported extractable results. The outcome measure of interest was change in lumbar spine @entity79 ( @entity79 ). We identified 45 eligible trials, which provided 49 eligible treatment comparisons (some trials had three arms or more). Our results indicated that @entity171 were the most effective class (effect size 1.03; 95% CI: 0.85, 1.17); results were similar even when newer generations of @entity1568 -containing @entity171 were excluded from analysis. We found the efficacy of @entity171 was enhanced further when used in combination with @entity560 (effect size, 1.31; 95% CI: 1.07, 1.50). @entity560 and @entity175 were more effective than no therapy/ @entity460 (effect size, 0.46; 95% CI: 0.27, 0.62; and effect size, 0.51; 95% CI: 0.33, 0.67, respectively) and were of similar efficacy, but both were significantly less effective than @entity171 . @entity1388 appeared effective, but there were too few studies (n = 5) to draw robust conclusions regarding its efficacy compared with the other three therapies. In summary, @entity171 are the most effective of evaluated agents for managing corticosteroid-induced @entity170 . The efficacy of @entity171 is enhanced further with concomitant use of @entity560 .
