[Comparison of carbetocin and oxytocin effectiveness for prevention of postpartum XXXX after caesarean delivery].

@entity1 @entity190 @entity548
OBJECTIVES: The aim of the study was to compare the effectiveness of carbetocin and oxytocin for prevention of postpartum @entity548 (PPH) after caesarean section. MATERIAL AND METHODS: We analyzed data from 279 @entity1 who received 100  g of carbetocin intravenously or 10 IU of oxytocin into the uterine muscle as a rudimentary treatment for prevention of PPH. RESULTS: @entity190 was statistically significantly higher (p=0.0136) in the entire study group as compared to the oxytocin group, and in cases when additional uterotonics were administered (p=0.0090). Also, we observed a statistically significantly correlation between the need for additional treatment and @entity1 BMI. @entity1 with pre-pregnancy BMI of >= 25 more often required additional medicaments after administration of carbetocin as compared to oxytocin (p=0.0077). We noted a statistically significantly higher rate of using additional treatment (p<0.05) after administering oxytocin into the uterine muscle as compared to intravenously given carbetocin (75% vs. 33%, respectively). CONCLUSIONS: 1. Carbetocin is more effective than oxytocin in the prevention of PPH and significantly reduces the necessity to administer therapeutic uterotonics during caesarean delivery. 2. Higher rates of additional treatment with uterotonics after the administration of carbetocin as compared to oxytocin in a group of @entity1 after2 or more cesarean sections and @entity1 with BMI of >= 25 require further studies in a target-selected larger sample size. 3. Based on our findings, it is not possible to conclude that 100  g of intravenous carbetocin is more effective than 10 IU of oxytocin given to the uterine muscle during caesarean delivery to prevent PPH.
