Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood XXXX : A Pilot Study.

@entity3519 @entity1 @entity2472
UNASSIGNED: Abnormal motor cortex activity is common in @entity3519 . Cathodal transcranial direct current stimulation may alter cortical activity by decreasing excitability while anodal stimulation may increase motor learning. Previous results showed that a single session of cathodal transcranial direct current stimulation can improve symptoms in childhood @entity3519 . Here we performed a 5-day, sham-controlled, double-blind, crossover study, where we measured tracking and muscle overflow in a myocontrol-based task. We applied cathodal and anodal transcranial direct current stimulation (2 mA, 9 minutes per day). For cathodal transcranial direct current stimulation (7 @entity1 ), 3 subjects showed improvements whereas 2 showed worsening in overflow or tracking error. The effect size was small (about 1% of maximum @entity2472 ) and not clinically meaningful. For anodal transcranial direct current stimulation (6 @entity1 ), none showed improvement, whereas 5 showed worsening. Thus, multiday cathodal transcranial direct current stimulation reduced symptoms in some @entity1 but not to a clinically meaningful extent, whereas anodal transcranial direct current stimulation worsened symptoms. Our results do not support transcranial direct current stimulation as clinically viable for treating childhood @entity3519 .
