Role of free @entity26 radicals in the development of @entity344 in XXXX @entity295 .

@entity375 @entity295 @entity998 @entity16 @entity1049 @entity26 @entity344 @entity5828 @entity224 @entity468 @entity551 @entity526
Live @entity526 were infused into anesthetized @entity468 given 0.6 ml bile/kg and 80 mM @entity5828 into the stomach. @entity551 , cardiac output, and gastric blood flow were monitored. @entity344 flow were measured by microspheres. The microscopic @entity16 was graded 0-4 (stomach) or 0-5 (intestine). One group of @entity468 (N = 8) received 5 mg @entity375 CuZn @entity224 dismutase (SOD) as a bolus before bacteria followed by infusion 50 mg/3 hr. Four of these @entity468 were also given catalase in the same dose. Controls (N = 8) had no treatment. After 3 hr gastric ulceration (grades 2-4) was found in controls but only in 50% of treated @entity468 (P less than 0.1). About 50% and 25% of the @entity468 in both groups developed significant small intestinal and @entity1049 , respectively. SOD or SOD/catalase had no effect on late systemic @entity551 , @entity998 , or transient increase in pulmonary pressure. Total gastric blood flow did not change, while at late @entity295 gastric mucosal flow was decreased in the treated group. Small intestinal mucosal flow decreased in both series. It is concluded that free @entity26 radicals may be of partial importance in the development of @entity295 -induced gastric, but not intestinal, @entity16 .
