An exaggerated blood pressure response to exercise is associated with subclinical XXXX in normotensive individuals.

@entity1 @entity296 @entity101 @entity13519 @entity6475 @entity299
OBJECTIVES: An exaggerated blood pressure (BP) response to exercise is associated with adverse cardiovascular outcomes, even in normotensive individuals. The purpose of this study was to compare myocardial function between normotensive individuals with and without an exaggerated BP response. METHODS: We evaluated global myocardial function using speckle tracking echocardiography in normotensive individuals. Two-dimensional speckle tracking echocardiography and a treadmill exercise test were performed simultaneously in 171 normotensive individuals (mean age: 48  8 years; 97 @entity1 ) without any structural @entity299 . RESULTS: Among 171 normotensive individuals, 19 (11%) exhibited an exaggerated BP response (>= 200 mmHg for @entity1 and >= 190 mmHg for @entity1 ) during the treadmill test. Conventional echocardiographic parameters were similar between the two groups. However, on strain analyses, the systolic and early @entity6475 of the left ventricle (LV) and left atrium were lower in individuals with an exaggerated BP response to exercise. The peak @entity13519 during exercise was inversely related to @entity299 of the LV (r=-0.35, P<0.01) and left atrium (r=-0.41, P<0.01). On multivariate analyses, an exaggerated BP response to exercise was shown to be an independent determinant of reduced global longitudinal strain of the LV (b=-0.20, P<0.05) and left atrium (b=-0.28, P<0.05). CONCLUSION: Normotensive individuals with an exaggerated BP response to exercise exhibit @entity296 . Even without apparent @entity101 , an exaggerated BP response could cause repeated increases in afterload and result in subclinical @entity296 .
