Eight Weeks of Cosmos caudatus (Ulam Raja) Supplementation Improves Glycemic Status in XXXX with Type 2 Diabetes: A Randomized Controlled Trial.

@entity1 @entity6 @entity2690 @entity164 @entity2412 @entity413
Objectives. Optimizing glycemic control is crucial to prevent @entity2412 . Cosmos caudatus is reported to have promising effect in improving plasma blood @entity413 in an animal model. However, its impact on @entity1 remains ambiguous. This study was carried out to evaluate the effectiveness of C. caudatus on glycemic status in @entity1 with @entity164 2 @entity6 . Materials and Methods. In this randomized controlled trial with two-arm parallel-group design, a total of 101 subjects with @entity164 2 @entity6 were randomly allocated to @entity6 or @entity6 controls for eight weeks. Subjects in @entity6 group consumed 15   g of C. caudatus daily for eight weeks while @entity6 controls abstained from taking C. caudatus. Both groups received the standard lifestyle advice. Results. After 8 weeks of supplementation, C. caudatus significantly reduced serum @entity2690 (-1.16 versus +3.91), reduced HOMA-IR (-1.09 versus +1.34), and increased QUICKI (+0.05 versus -0.03) in @entity6 group compared with the @entity6 controls. HbA1C level was improved although it is not statistically significant (-0.76% versus -0.37%). C. caudatus was safe to consume. Conclusions. C. caudatus supplementation significantly improves @entity2690 resistance and @entity2690 sensitivity in @entity1 with @entity164 2 @entity6 .
