Competing cardiovascular outcomes associated with electrocardiographic left XXXX : the @entity731 Risk in Communities Study.

@entity1 @entity712 @entity301 @entity123 @entity731 @entity65
BACKGROUND: Individuals with electrocardiographically determined left @entity123 (ECG LVH) are at risk of multiple @entity65 ( @entity65 ) outcomes simultaneously. The study sought to characterise the competing incidences for subtypes of first @entity65 events or non- @entity65 death in those with and without ECG LVH. METHODS: @entity1 in the @entity731 Risk in Communities (ARIC) Study were included. ECG LVH was defined according to Sokolow-Lyon criteria. Competing Cox models were used to compare hazards for diverse outcomes within groups (e.g., among those with ECG LVH) and for a given event between groups (ECG LVH vs. no ECG LVH). RESULTS: After 15 years, @entity1 with ECG LVH at baseline (N=383) had a cumulative incidence of first @entity65 events and non- @entity65 deaths of 29.2% and 6.1%, respectively (HR 4.86; 95% CI 3.04 to 7.77). In @entity1 without ECG LVH (N=6576) the incidence of any first @entity65 event and non- @entity65 death was 18.9% and 6.9%, respectively (HR 2.67; 2.39 to 2.98). Similar associations were observed in @entity1 (N=381 with and N=8187 without ECG LVH). @entity301 ( @entity301 ) was the most common first event in @entity1 with ECG LVH (15.0%) and @entity712 was the most common first event in @entity1 with ECG LVH (10.5%). After adjustment for risk factors including systolic blood pressure, any @entity65 event remained the most likely first event. CONCLUSIONS: Among middle-aged individuals with ECG LVH, the most likely first events are @entity301 in @entity1 and @entity712 in @entity1 ; these results may have implications for preventive approaches.
