XXXX in pregnancy: once-a-day @entity2756 versus multiple doses of @entity7048 . A randomized, double-blind trial.

@entity1 @entity2756 @entity7048 @entity2885
OBJECTIVE: The purpose of this study was to compare the efficacy of a single daily dose of intravenous @entity2756 with that of multiple-dose @entity7048 in the treatment of acute @entity2885 in pregnancy. STUDY DESIGN: This was a double-blind, randomized, clinical trial. @entity1 admitted to the hospital with the diagnosis of acute @entity2885 in pregnancy were enrolled and randomized according to a computer-generated randomization schedule. The study group received a single daily 1 gm dose of @entity2756 intravenously along with two additional doses of normal saline solution. The comparison group received three daily 2 gm doses of @entity7048 intravenously. All infusions were given on an 8-hour schedule. Treatments were continued until the @entity1 became afebrile. Each @entity1 was discharged from the hospital on a regimen of appropriate oral antibiotics as directed by urine culture and sensitivities. At follow-up visits test-of-cure cultures were obtained. RESULTS: During the 2-year study period, 178 @entity1 were randomized: 88 received @entity7048 and 90 @entity2756 . @entity1 demographics and presenting signs and symptoms were similar in both groups. No differences were noted between the groups regarding days of febrile morbidity, length of hospital stay, or treatment failures. CONCLUSIONS: Daily single-dose intravenous @entity2756 is as effective as multiple-dose @entity7048 in the treatment of @entity1 with acute @entity2885 during pregnancy.
