Comparison of 1-day versus 1-hour application of topical neomycin/ @entity6414 before XXXX surgery.

@entity1 @entity231 @entity6414 @entity4279 @entity6353 @entity597
PURPOSE: To compare the efficacy of 2 prophylaxis regimens before @entity231 surgery using topical antibiotics (1 hour before surgery versus the day before), both with @entity4279 , with regard to reducing the preoperative conjunctival bacterial load. SETTING: Tertiary ophthalmic referral center, Munich, Germany. DESIGN: Prospective comparative case series. METHODS: Eyes were treated with topical antibiotics and their conjunctival sac flush irrigated using 10 mL of @entity4279 1.0%. All eyes were randomized to receive either 4 applications of topical 3500 IU/mL neomycin @entity597 /6000 IU/mL @entity6414 sulfate within 1 hour preoperatively (Group 1) or on the day before surgery (Group 2). Conjunctival specimens were obtained at 4 timepoints: T0C untreated fellow eye (control), T0 surgery eye (after antibiotic prophylaxis but before @entity4279 irrigation), T1 after @entity4279 , and T2 at the conclusion of surgery. All specimens were inoculated onto blood and @entity6353 -blood agar and into thioglycollate broth. RESULTS: One hundred thirty-three eyes of 133 consecutive @entity1 were included (Group 1, 64 eyes; Group 2, 69 eyes). The antibiotic regimens were equally effective in reducing the aerobic and microaerophilic conjunctival flora (Group 1, P=.028; Group 2, P=.000), but had no significant effect on anaerobic bacteria (Group 1, P=.201; Group 2, P=.117). Flush irrigation of the conjunctival sac using 10.0 mL @entity4279 1.0% significantly decreased the conjunctival bacterial load in both groups. CONCLUSION: Topical neomycin/ @entity6414 was equally effective in reducing the conjunctival bacterial load whether given 1 day or 1 hour before surgery. The greatest effect was achieved by irrigating the conjunctival sac using @entity4279 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
