Recombinant XXXX interferon-alpha I 1 inhibits the migration of lymphocytes from lymph nodes but not into lymph nodes.

@entity2920 @entity291 @entity742 @entity794
Recombinant @entity291 interferon-alpha I 1 ( @entity2920 ) was tested for effects on lymphocyte migration into and out of the lymph nodes of @entity742 . Chronic lymph drainage methods were used to monitor the efferent lymph of single lymph nodes of unanaesthetized animals. When @entity2920 was injected into the drainage area of the lymph node, infused directly via an afferent lymphatic, or injected intravenously, a marked decrease in cell output was observed. Nanogram quantities of @entity2920 produced an effect that lasted several hours. To test whether this effect was specific for lymphocytes, we first stimulated a lymph node with @entity794 so that large numbers of neutrophils and lymphocytes were present in efferent lymph. When @entity2920 was then injected, the lymphocytes disappeared from efferent lymph but the neutrophils did not. Normal efferent lymph cells were labeled with radioisotopes and injected intravenously during the @entity2920 induced effect. The entry of lymphocytes from the blood was significantly enhanced at a time coinciding with the suppressed cell exit in the efferent lymph. Recovery data indicated that the lymphocytes were retained temporarily in the lymph node but were not destroyed. Furthermore, the @entity291 @entity2920 does not appear to be conspicuously antigenic in @entity742 . It is not yet certain whether @entity2920 enhances the interactions of cells within the lymph node thereby potentiating immunologic reactions.
