Metastatic @entity2828 / XXXX of bone at diagnosis: prognostic factors--a report from Saudi Arabia.

@entity1 @entity2828 @entity6196 @entity5
BACKGROUND: To evaluate outcome and prognostic factors in Saudi Arabian @entity1 with metastatic @entity2828 and @entity6196 of bone (PMES) at diagnosis. PROCEDURE: Ninety-nine of 304 (33%) consecutive @entity1 with @entity2828 and @entity6196 of bone registered at our centre from 1975 to 1998, had metastatic disease at registration and 93 were available for analysis. The maximum x-axis diameter of the @entity5 was used as the measure of @entity5 size. Usually a trial of systemic treatment was undertaken before a decision was made on local treatment. Standard chemotherapy regimens were used in all treated @entity1 . Forty-one (44%) @entity1 did not receive radical local treatment due to an inadequate response to chemotherapy, or a decision not to undertake more than palliative treatment. Radical treatment of the primary site was radiation alone 41 (79%), resection alone 7 (13%), and resection and radiation 4 (8%). RESULTS: The 5-year survival rates were 9% for all 93 evaluable @entity1 , 16% for 52 @entity1 who received chemotherapy and radical local treatment, 0% for 41 @entity1 who received lesser treatment, 19% for 43 @entity1 with lung metastases alone, and 0% (P = 0.002) for 50 @entity1 with other sites involved. For 60 @entity1 with imaging data, 5-year survivals were 34 and 0% when the maximum transverse diameter of the @entity5 was < 10 cm (N = 20) and > or = 10 cm (N = 40), respectively. CONCLUSIONS: Small @entity5 size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results.
