Pilot study for family-based association analysis of XXXX in a Korean population: Analysis for candidate genes positionally on chromosome 18q21.

@entity1032 @entity71705 @entity71706 @entity71710 @entity71713 @entity71711 @entity71707 @entity161 @entity716 @entity71708 @entity1594 @entity71712 @entity71709 @entity47410
INTRODUCTION: @entity161 is the most devastating @entity1032 that causes severe deterioration in social and occupational functioning. This is a pilot study for family-based association analysis of @entity161 in a Korean population to search candidate genes functionally relevant and positionally on chromosome 18. METHODS: We have recruited 27 probands (with @entity716 ) with their parents and siblings whenever possible. We analyzed 20 SNPs (Single Nucleotide Polymorphism) of seven neuronal genes in chromosome 18 for DNA samples that was checked for the data quality and genotype error. For testing of association, we performed family-based association tests analyses with each individual SNP, using the phenotype of @entity716 . And then, we performed family-based association tests haplotype analyses with each individual SNP, using the phenotype of @entity716 . Finally, we performed linkage disequilibrium analyses for the phenotype of @entity161 . RESULTS: We found one significant SNPs of one neuronal gene in chromosome 18 (P value   <   0.05) for the qualitative phenotype of @entity716 ( @entity71705 : @entity47410 ). We also found significant haplotypes of four SNPs in @entity47410 ( @entity47410 ) gene of chromosome 18 (P value   <   0.1) for the phenotype of @entity716 ( @entity71705 - @entity71706 - @entity71707 - @entity71708 ). Two SNPS within the @entity47410 gene ( @entity71708 , @entity71709 ), plus SNPs within the malic enzyme 2 ( @entity71710 , @entity71711 ), and @entity1594 genes ( @entity71712 , @entity71713 ) were in strong linkage disequilibrium with each other (D'   >   0.60). DISCUSSION: The present findings provide convergent evidence (fine mapping of a chromosomal locus 18q21 associated with @entity161 ) suggesting that a specific @entity47410 could be a candidate gene for causing a spectrum of @entity161 phenotype.
