Long-term correction of hyperglycemia and XXXX in @entity1723 . A five-year randomized prospective study.

@entity1 @entity6 @entity1723 @entity989 @entity413
Thirty-eight @entity1 with @entity1723 who had background @entity989 and no residual endogenous insulin secretion as assessed by plasma C-peptide determinations, were randomized to either conventional insulin treatment or to more intensive @entity413 control using ultralente insulin as basal cover and soluble insulin at mealtimes and were followed for five years. Plasma @entity413 profile and glycosylated hemoglobin were determined every eight weeks. Eye examinations were performed at the start of the study and after one, three and five years. Age, duration of @entity6 , insulin dosage, glycemic control were comparable in the two groups. The mean plasma @entity413 profile was similar at entry in both groups and did not change in the conventionally-treated group. Mean plasma @entity413 profile 11.2 +/- 1 mmol/l with glycosylated hemoglobin level 10.7 +/- 0.3% fell to 7.9 +/- 0.4 mmol/l and 8.7 +/- 0.5% respectively during intensive treatment. Retinal morphology deteriorated during the follow-up with no significant differences between @entity1 under unchanged conventional treatment and intensive insulin regimen. @entity989 developed in six @entity1 --three of these were under intensive insulin treatment. These data suggest that substantial long-term improvement of glycemic control does not affect progression of background @entity989 even when it is mild. The evolution of established @entity989 in insulin dependent @entity6 @entity1 is not only a function of poor glycemic control; other factors, either intrinsic or environmental, must also be important.
