Age-related changes in @entity165 and @entity6741 metabolism in spontaneously @entity101 XXXX .

@entity101 @entity1007 @entity6742 @entity17659 @entity412 @entity3150 @entity6741 @entity382 @entity35 @entity3645 @entity165
Age-related changes in serum and liver @entity165 , phospholipid and @entity412 levels, serum lipoproteins, biliary secretion of @entity165 , phospholipids and @entity3645 , fecal excretion of @entity3150 and @entity3645 , and the pool size of @entity3645 were examined in spontaneously @entity101 @entity35 (SHR) and @entity35 -Kyoto @entity35 (WKR). SHR showed distinct age- and sex-related changes when young and marked aged- @entity35 @entity1007 after 1 yr of age. (1) @entity165 shifted from blood to the liver between 10 and 20 wk only in male SHR and not at all in WKR. (2) Serum lipoprotein percentages changes; alpha-lipoprotein decreased, pre-beta-lipoprotein increased, but beta-lipoprotein did not change. These changes appeared only in male SHR and after 13 to 15 wk of age. (3) @entity382 in SHR, although not detected at 5 to 6 wk, progressed more rapidly than in WKR, giving values almost double those in WKR after 13 to 15 wk. @entity382 in female SHR was much less than in the male. (4) Bile flow, biliary secretion, and the pool size of @entity3645 increased. However, when expressed on the basis of liver weight, these values were similar to those in WKR, suggesting that the increases were caused by the @entity382 . (5) Differences appeared in the @entity6741 composition. A large amount of @entity17659 was present in SHR of both sexes and the @entity6742 percentage was low in male SHR. (6) Changes were observed in fecal @entity6741 excretion. Since the daily amounts in male SHR were similar to those in WKR, the hepatic synthesis activity (mg per day per 10 g liver) in male SHR was almost half that in WKR at all ages.
