Hyponatraemia: A strong predictor of mortality in adults with XXXX .

@entity1 @entity1372 @entity299 @entity1011 @entity6924 @entity204
AIMS: We studied the prevalence of hyponatraemia and its prognostic implications in a large population of adult @entity1 with @entity299 (ACHD). METHODS AND RESULTS: A total of 1004 ACHD @entity1 were retrospectively entered in this study (mean age 36.2 +/- 14.4 years, 48.7% male). Cox regression was used to estimate mortality associated with hyponatraemia, adjusted for potential confounders using both multivariable regression and propensity score matching. Mean @entity1372 concentration in this ACHD cohort was 137.6 +/- 2.6 mmol/L. The overall prevalence of hyponatraemia in this cohort was 15.5% and was highest in congenitally corrected transposition (33.3%), after Fontan operation (29.6%), and in @entity1 with @entity6924 (22.0%). Predictors of hyponatraemia were worse functional class, cyanosis, higher serum @entity1011 levels, and treatment with diuretics. @entity1 were followed for a median of 4.1 years, during which there were 96 deaths. Hyponatraemia was a strong predictor of @entity204 , independent of age, previous surgery, functional class, systemic ventricular function, @entity1011 levels, and the use of diuretics (adjusted HR 2.82, 95% CI: 1.72-4.63, P < 0.0001). CONCLUSION: Hyponatraemia is relatively common in ACHD. Hyponatraemia carries a three-fold higher risk of @entity204 in ACHD and is a simple, cheap but powerful marker of mortality.
