The Disposition of XXXX and Metabolite in Human Hair.

@entity12336 @entity1288 @entity71774 @entity5708
UNASSIGNED: The disposition of @entity1288 ( @entity5708 ) and metabolites in hair remains poorly characterized. We present a case involving a pharmacist in an impaired professionals' monitoring program in whom hair testing yielded @entity5708 on two occasions. On both occasions, his hair was negative for the @entity12336 (OM) metabolite at the cutoff concentration of 100 pg/mg. He claimed that, absent the detection of metabolite, the @entity5708 necessarily represented external contamination. This prompted a review of the laboratory's @entity5708 -positive hair results for the quarter April-June 2014. Overall, 466 specimens contained @entity5708 , with a mean (median) concentration of 2,375 (1,060) pg/mg. Of these @entity5708 -positive specimens, only 47 (10%) contained detectable OM. When @entity5708 was present at or below the mean (median) concentration, only 2.2% (1.3%) of specimens were OM-positive. In the setting of @entity5708 administration, the detection of OM in hair is unlikely at a cutoff concentration of 100 pg/mg. More consistent demonstration of @entity5708 metabolite(s) in hair will require the validation of methods to detect OM at lower concentrations and/or methods to detect @entity71774 .
