A comparison of the effects of converting-enzyme inhibition and protein restriction in experimental XXXX .

@entity632 @entity8 @entity1985 @entity1184 @entity3371 @entity3450 @entity35
We compared the effects of protein restriction and converting-enzyme inhibition by @entity3371 (CAP) on urinary protein excretion (UP) and progressive @entity8 ( @entity8 ) in an experimental model of @entity3450 induced in @entity35 by a single injection of @entity632 (ADR) at a dose of 3 mg/kg. Two isocaloric diets with a 6% and 22% (NP) protein content were used. Experimental groups were started on NP, on NP plus CAP (500 mg/liter) or on an isocaloric diet with a 6% protein content at day 2 after ADR injection and followed for 38 days. According to a cross-over design, groups were then switched to the alternative diet or maintained on the original diet, whereas in one CAP-treated group CAP treatment was stopped. All groups were followed for another 34 to 42 days and then sacrificed. Results showed that UP and the incidence of @entity8 were significantly reduced in groups on the isocaloric diet with a 6% protein content during the full length or the second half of the observation period. In contrast, CAP had no effect on UP or on the incidence of @entity8 , although systolic blood pressure was significantly reduced. Renal function studies performed in separate groups on the same regimes at 5 weeks after induction of ADR @entity3450 , showed that LP had lowered glomerular filtration rate numerically and renal plasma flow significantly, whereas CAP was found to have no effect on glomerular filtration rate and renal plasma flow. Glomerular volumes were increased in proteinuric @entity35 on both NP diet and NP diet with CAP treatment. The present study confirms earlier reports that in ADR- @entity1985 @entity35 , protein restriction attenuates UP and @entity8 without affecting systolic blood pressure, whereas converting-enzyme inhibition does not have this beneficial effect although systolic blood pressure is lowered. @entity8 seems to be related to glomerular extension and @entity1184 . The effect of protein restriction may be partially hemodynamically mediated by afferent vasoconstriction, resulting in a decrease in glomerular filtration rate and a reduction in protein flux across the ADR-induced large pore defects.
