Deletion of XXXX cannabinoid receptor induces @entity161 -related behaviors in @entity19 .

@entity146 @entity14651 @entity19 @entity935 @entity73 @entity7097 @entity2072 @entity161 @entity750 @entity9767 @entity1090
The possible role of the @entity14651 ( @entity14651 ) in @entity146 has been considered. Several animal models use knockout (KO) @entity19 that display @entity161 -like behaviors and this study evaluated the role of @entity14651 in the regulation of such behaviors. @entity19 lacking the @entity14651 (CB(2)KO) were challenged in open field, light-dark box, elevated plus-maze, tail suspension, step down inhibitory avoidance, and pre-pulse inhibition tests (PPI). Furthermore, the effects of treatment with @entity2072 and @entity1090 were evaluated using the OF and the PPI test. Gene expression of @entity935 D(2)   ( @entity9767 ), adrenergic-a(2C)   (a(2C)r), serotonergic @entity750 (2A) and @entity750 (2C) receptors ( @entity750 (2A)r and @entity750 (2C)r) were studied by RT-PCR in brain regions related to @entity161 . Deletion of @entity14651 decreased motor activity in the OF test, but enhanced response to acute @entity2072 and produced mood-related alterations, PPI deficit, and @entity73 . Chronic treatment with @entity1090 tended to impair PPI in @entity7097 @entity19 , whereas it 'normalized' the PPI deficit in CB(2)KO @entity19 . CB(2)KO @entity19 presented increased @entity9767 and a(2C)r gene expressions in the prefrontal cortex (PFC) and locus coeruleus (LC), decreased @entity750 (2C)r gene expression in the dorsal raphe (DR), and @entity750 (2A)r gene expression in the PFC. Chronic @entity1090 treatment in @entity7097 @entity19 left a(2C)r gene expression unchanged, decreased @entity9767 gene expression (15    g/kg), and decreased @entity750 (2C)r and @entity750 (2A)r in PFC and DR. In CB(2)KO, the gene expression of @entity9767 in the PFC, of a(2C)r in the LC, and of @entity750 (2C)r and @entity750 (2A)r in PFC was reduced; @entity750 (2C)r and @entity750 (2A)r gene expressions in DR were increased after treatment with @entity1090 . These results suggest that deletion of @entity14651 has a relation with @entity161 -like behaviors. Pharmacological manipulation of @entity14651 may merit further study as a potential therapeutic target for the treatment of @entity161 .
