Effects of the Cessation of Mass Screening for XXXX at 6 Months of Age: A Population-Based Study in Osaka, Japan.

@entity1 @entity4180 @entity521
BACKGROUND: In 2004, the Japanese government halted the 6-month mass screening program for @entity521 . We investigated whether its cessation had led to an increase not only in mortality due to this disease but also in the incidence of advanced-stage disease among older @entity1 . METHODS: Study subjects were @entity521 @entity1 retrieved from the population-based Osaka Cancer Registry. Trends of incidence and mortality from @entity521 were analyzed by calendar year and birth cohort. Prognostic factors, including stage and v-myc avian myelocytomatosis viral oncogene @entity521 derived homolog ( @entity4180 ) oncogene status, were compared before and after the cessation of mass screening. RESULTS: Age-standardized incidence rates in 2005-2009 (the cessation period of mass screening; 11.1 per million) were similar to those in 1975-1979 (the pre-screening period; 8.6 per million). Age-standardized mortality rates tended to decrease from 1975-1979 (4.0 per million) to 2005-2009 (2.7 per million) in parallel with the improvement in survival. Analysis by birth cohort indicated that the mortality rates in 2004-2005 (after cessation) for @entity1 0-4 years of age were lower than those in 1975-1979 (O:E ratio 0.25; 95% confidence interval, 0.03-0.90). For @entity1 1-9 years of age, there was a not significant difference in the distribution of stage, @entity4180 oncogene status, and DNA ploidy between 1991-2003 (the mass screening period) and 2004-2008 (after cessation). CONCLUSIONS: The cessation of mass screening for @entity521 does not appear to have increased mortality due to this disease or incidence of advanced-stage disease among older @entity1 .
