XXXX in total joint replacement.

@entity1 @entity691 @entity738 @entity3677 @entity158
Fourteen @entity1 (15 joints) developed a foreign body reaction to @entity3677 , @entity691 , or metal adjacent to a total joint implant, a condition we would like to term @entity738 . There were eight male and six female @entity1 . Their average age was 61 years. The hip was involved in 14 joints (femoral component 11 times, acetabulum 7, and greater trochanter once). One @entity1 presented with @entity738 of the knee. The principal findings included increasing @entity158 and radiographic evidence of loosening occurring on average 2.7 years following the implant. This was followed by a characteristic and gradually developing radiographic pattern of discrete rounded lucencies. These developed into large ovoid lytic areas, destroying both @entity3677 and bone. Histologically, the appearances were characterized by histiocytic infiltration and the presence of multiple foreign body giant cells. Foreign material was identified in 9 of 11 cases. The pathogenesis is unknown but appears related to micromovement or loosening of the implant.
