Hormone-induced XXXX affects early embryonic development.

@entity1 @entity19 @entity31806 @entity245 @entity1155
OBJECTIVE: To analyze the effects of @entity245 on embryonic development in @entity19 , because intrafollicular oocyte development may be delayed during assisted reproductive technology (ART) treatment in @entity1 . DESIGN: Experimental @entity19 study. SETTING: University hospital. ANIMAL(S): Female C57Bl/6 @entity19 . INTERVENTION(S): @entity31806 is used as a GnRH-antagonist in ART treatments. To assess the effect of @entity245 on embryonic development, @entity31806 was applied concomitantly with follicle stimulation by pregnant mare serum gonadotropin. Ovulation was induced by hCG. Controls were stimulated with pregnant mare serum gonadotropin without delaying ovulation. @entity1155 was assessed from the number of tertiary follicles, ruptured follicles, and corpora lutea in @entity19 ovaries after @entity31806 treatment. Number and weight of embryos and placentas, as well as number of resorption sites and dead embryos, was determined on day 17.5 of pregnancy. MAIN OUTCOME MEASURE(S): Inhibition of ovulation, embryonic development. RESULT(S): @entity31806 inhibited ovulation in @entity19 , as shown by an increase in number of tertiary follicles concomitant with a significant inhibition of follicle rupture and corpora lutea formation. @entity245 caused by @entity31806 treatment led to a significant increase in resorption sites and a significant decrease in embryonic weight of offspring. CONCLUSION(S): Preovulatory oocyte overripeness might have an effect on fertility and embryonic development during ART treatment.
