XXXX levels in an elderly population from the community--The implications of sex.

@entity1 @entity6949 @entity65
OBJECTIVES: The importance of sex on cardiac troponin levels is increasingly recognized. We investigated whether the entities associated with troponin leakage and the prognostic consequences thereof would differ between elderly @entity1 and @entity1 from the community. DESIGN AND METHODS: @entity6949 ( @entity6949 ) levels were measured using a high-sensitivity assay (Abbott Laboratories) in 70-year old @entity1 (n = 502) and @entity1 (n = 502) from the PIVUS study. All study @entity1 were followed up for 10 years regarding all-cause mortality and incident @entity65 . RESULTS: Median @entity6949 levels were 4.1 and 3.0 ng/L in @entity1 and @entity1 , respectively (p<0.001). By multiple linear regression, the relative contribution of lower left-ventricular ejection fraction and ischemic ECG changes to @entity6949 levels was greater in @entity1 compared to @entity1 . For other clinical and echocardiographic variables, similar associations were found. @entity6949 independently predicted all-cause mortality in @entity1 (n = 93 [18.5%]; hazard ratio [HR] 1.38 [1.12-1.70]) and @entity1 (n = 62 [12.4%]; HR 1.59 [1.11-2.28]) but not incident CV disease in subjects being CV healthy at baseline (n = 163/857). The interaction terms of sex on the associations of @entity6949 with both outcomes were non-significant. Sex-specific cut-offs did not improve prognostication. Variations in the pattern of entities associated with @entity6949 leakage had no impact on event rates. CONCLUSIONS: We found some differences in the entities associated with higher @entity6949 levels in elderly community-dwelling @entity1 and @entity1 . However, this did not translate into differences in the associations of @entity6949 with adverse outcome.
