The prognostic importance of different XXXX in @entity712 .

@entity1 @entity712 @entity177 @entity1011 @entity204
BACKGROUND: Worsening renal function in @entity1 hospitalized for @entity712 portends a poor prognosis. However, criteria used to define worsening renal function are arbitrary, and the implications of different definitions remain unclear. We therefore compared the prognostic importance of various @entity177 in 1,002 @entity1 hospitalized for @entity712 ( @entity712 ). METHODS AND RESULTS: The @entity1 population was 49% female, aged 67 +/- 15 years. Twenty-three percent had a prior history of @entity177 , 73% had known depressed ejection fraction, and 63% had known @entity712 . On admission to the hospital, 47% were receiving ACE inhibitors, 22% beta-blockers, 70% diuretics and 6% NAID's. 72% developed increased serum @entity1011 during the hospitalization, with 20% developing an increase of > or = 0.5 mg/dL. Worsening renal function predicted both in-hospital mortality and length of stay > 10 days. Even an increased @entity1011 of 0.1 mg/dL was associated with worse outcome. Sensitivity for @entity204 decreased from 92% to 65% as the threshold for increased @entity1011 was raised from 0.1 to 0.5 mg/dL, with specificity increasing from 28% to 81%. At a threshold of a 0.3 mg/dL increase, sensitivity was 81% and specificity was 62% for @entity204 and 64% and 65% for length of stay >10 days. Adding a requirement of final @entity1011 of > or = 1.5 mg/dL improved specificity. CONCLUSIONS: This analysis demonstrates that any detectable decrease in renal function is associated with increased mortality and prolonged hospital stay. This suggests that therapeutic interventions which improve renal function might be beneficial.
