Clinical significance of secreted protein acidic and rich in XXXX and its relation to @entity189 progression.

@entity1 @entity9618 @entity1476 @entity5 @entity189 @entity418 @entity3
BACKGROUND: Secreted protein acidic and rich in cystein ( @entity9618 ) is a small extramatrix-associated protein. Its production increases during angiogenesis and enhances @entity1476 ( @entity1476 ) expression. The goal of this study was to show the clinical relevance of @entity9618 and its relation to @entity1476 expression in @entity418 @entity1 . METHODS: The authors investigated @entity9618 mRNA expression in 48 tissue samples of @entity5 characterized by @entity1476 mRNA expression in a Northern blot analysis. Western blot analysis and immunohistochemistry were also performed in @entity418 tissue samples. RESULTS: All 48 tissue specimens had high expression of @entity9618 mRNA. Quantitative evaluation showed that high @entity9618 mRNA was associated significantly with lymph node @entity3 (P = 0.05) and poorer prognosis (P = 0.025). Expression of @entity9618 mRNA was associated significantly with @entity1476 mRNA expression (R = 0.65; P < 0.01). Both @entity9618 and @entity1476 were immunolocalized intensely in @entity189 and stromal cells, whereas normal esophageal mucosa and submucosa did not express @entity9618 . The 35-kilodalton cleaved @entity9618 was detected in @entity418 tissue specimens by Western blot analysis and it was associated with @entity1476 mRNA expression. CONCLUSIONS: In terms of clinical significance, @entity9618 accumulation may reflect a functional correlation with @entity1476 and the associated expression could play a key role in the progression of @entity418 .
