Studies on germinal effects of @entity3092 , a naturally occurring XXXX .

@entity1 @entity137 @entity19 @entity73 @entity6660 @entity3733 @entity3088 @entity29278 @entity35 @entity3092 @entity3096
@entity3092 ( @entity29278 ) is one of the most widely occurring @entity3088 ingested by @entity1 in food. It has been shown to be mutagenic in prokaryotes as well as in in vitro @entity1 cell lines. In view of the unavoidability of ingesting it via a normal diet, there is a need to assess the potential genetic risk to @entity1 , due to @entity3096 ingestion, using whole animal assays. Dominant lethal studies have been carried out in adult Swiss male @entity19 and @entity35 male @entity35 to investigate the germinal effects of @entity3092 . Adult Swiss males were treated with 200, 300 or 400 mg/kg of @entity3092 dissolved in 60% @entity3733 , intraperitoneally. In the @entity35 study, 200 and 300 mg/kg of @entity3092 were used. Individually caged males were paired with untreated females for a week and six sequential matings were carried out. Two independent experiments in @entity19 and a single experiment in @entity35 constituted the study. Females were evaluated for inducted dominant lethality during the midterm of pregnancy. At 200 mg/kg dose of @entity3092 , there were no significant differences between control and the test group in pregnancy, total or live implantations in @entity19 or @entity35 during the whole test period that could be attributed to the @entity3096 exposure. In @entity19 at 300 and 400 mg/kg of @entity3092 , there was a profound reduction in fertility of the males during all six matings. The number of total and live implantations also decreased, particularly at the 400 mg/kg dose, although the sample size was too small to be statistically significant. Contrary to this, the @entity35 study did not show any @entity73 , nor was there any substantial suppression of total and live implantations at the highest (300 mg/kg) dose tested. There were no significant differences between control and treated groups with regard to the number of dead implantations at any dosage level at any stage of the study in @entity19 and @entity35 . Thus, no post-implantation losses--a reliable measure of dominant lethal mutations--were induced by @entity3092 in @entity19 or @entity35 . The loss of fertility could be due to germinal @entity137 , @entity6660 or impairment of fertilizing ability of the treated animals.(ABSTRACT TRUNCATED AT 400 WORDS)
