Novel antiadhesion barrier does not prevent XXXX in a @entity95 model.

@entity834 @entity5224 @entity254 @entity95 @entity1104 @entity298
Intraperitoneal adhesions following surgical procedures cause considerable morbidity. Hyaluronic acid/ @entity5224 (HA/CMC) films have been shown to be effective agents in decreasing @entity1104 formation. However, when there is an inadvertent leak of bowel contents into the peritoneum due to incomplete @entity254 , @entity1104 formation about a defect in order to prevent further leakage and to promote healing of the wound is important for the prevention of morbidity and mortality. The purpose of this study was to determine if an antiadhesion film (HA/CMC) impairs these potentially beneficial adhesions to bowel anastomoses, thus predisposing them to enteric leaks with subsequent @entity298 . Sixty-four @entity95 were divided in two groups, each undergoing a complete or partial (90% @entity254 to simulate @entity834 ) large bowel @entity254 . Half of each of the above groups were treated by wrapping a HA/CMC film over the @entity254 and the other half were untreated controls. These two subgroups were then further divided equally and sacrificed at either 7 or 14 days for evaluation of @entity254 integrity and strength. The average anastomotic bursting pressures did not change significantly between those groups treated with HA/CMC when compared to untreated controls at 7 or 14 days or in the complete or partial @entity254 group (Student's t test). Adhesion formation to the @entity254 was not impaired in either group independent of HA/CMC film application. This study suggests that while HA/CMC film has been shown to decrease adhesions in other models, healing of a @entity95 colonic @entity254 even in the presence of an anastomotic defect takes place, further suggesting that the stimulus for @entity1104 formation can overcome the antiadhesion properties of HA/CMC.(ABSTRACT TRUNCATED AT 250 WORDS)
