The Effect of High-Frequency Stimulation on Sensory Thresholds in XXXX @entity1 .

@entity1 @entity2198 @entity602 @entity158 @entity1118
BACKGROUND: @entity2198 ( @entity2198 ) has recently gained attention as an alternative to parameters used in traditional @entity602 ( @entity602 ). Because @entity2198 is paresthesia free, the gate theory of @entity158 control as a basis of @entity602 has been called into question. The mechanism of action of @entity2198 remains unclear. OBJECTIVE: We compare the effects of @entity2198 and traditional @entity602 on quantitative sensory testing parameters to provide insight into how @entity2198 modulates the nervous system. METHODS: Using quantitative sensory testing, we measured thermal detection and @entity158 thresholds and mechanical detection and pressure @entity158 thresholds, as well as vibratory detection, in 20 @entity602 @entity1 off stimulation (OFF), on traditional stimulation (ON) and on @entity2198 in a randomized order. RESULTS: @entity2198 significantly increased the mechanical detection threshold compared to OFF stimulation (p < 0.001) and traditional @entity602 (p = 0.01). Pressure @entity158 detection and vibratory detection thresholds also significantly increased with @entity2198 compared to ON states (p = 0.04 and p = 0.01, respectively). In addition, @entity2198 significantly decreased 10- and 40-gram pinprick detection compared to OFF states (both p = 0.01). No significant differences between OFF, ON and @entity2198 states were seen in thermal and thermal @entity158 detection. CONCLUSION: @entity2198 is a new means of modulating @entity1118 . The mechanism by which @entity2198 works seems to differ from that of traditional @entity602 , offering a new platform for innovative advancements in treatment and a greater potential to treat @entity1 by customizing waveforms.
