[Prognostic value of cardiovascular MRI in XXXX .]

@entity1 @entity6 @entity741 @entity2287 @entity543
CLINICAL/METHODICAL ISSUE: Despite an increased cardiovascular risk in @entity1 with @entity6 they are a heterogeneous population with very different individual manifestation of diseases; therefore, a profound stratification is recommended. STANDARD METHODS: Clinical examinations and blood biomarkers are typically used in @entity6 @entity1 to determine the risk for developing cardio-cerebrovascular events. METHODICAL INNOVATIONS: Cardiac as well as whole-body magnetic resonance imaging (MRI) including cardiovascular sequences are established methods for clinical diagnostics. Their significance in predicting the outcome and the corresponding risk stratification for @entity1 with @entity6 is becoming increasingly more important based on recent study results. PERFORMANCE: Late @entity2287 enhancement (LGE) in cardiac MRI detects silent @entity741 in up to 30   % of @entity6 @entity1 , which is associated with a hazard ratio of 3-6 for cardiovascular events. Regional left ventricular wall motion abnormalities and decreased ejection fraction also have a prognostic value in @entity6 . Based on whole-body MRI, the vessel score as well as @entity543 have been evaluated as additional predictors for cardio-cerebrovascular events. ACHIEVEMENTS: The MRI-based predictors have independent and incremental prognostic value beyond traditional risk stratification for cardio-cerebrovascular events; however, only the comprehensive assessment of whole-body MRI including angiography allows the identification of @entity1 who remain free of cardio-cerebrovascular events over a period of 6  years. PRACTICAL RECOMMENDATIONS: Cardiac MRI, particularly the detection of LGE, can be recommended for risk stratification of @entity1 with @entity6 . The clinical relevance of the added prognostic value of whole-body MRI needs to be clarified in further studies.
