XXXX : A combined approach in the management.

@entity1 @entity2828 @entity66 @entity786 @entity4316 @entity3
Twenty-seven histologically confirmed cases of localised @entity2828 were treated by two different regimes. Radiotherapy alone was used in 13 cases and a combination of chemotherapy and radiotherapy in 14. Single agent chemotherapy ( @entity786 ) was given sequentially in nine @entity1 and @entity786 and @entity4316 in five. There is a significant difference in the response to these different regimes. Only 69.2% of @entity1 treated by radiotherapy alone were disease-free, for a median period of 10.4 months and @entity3 were noticed in 53.8% of cases. The disease-free survival in @entity1 treated by combination therapy (radiotherapy and chemotherapy) was 18.4 months and @entity3 were seen in only 42.9%. However, no @entity3 were seen in @entity1 who received @entity786 and @entity4316 , during a period of 14 months and only one @entity1 showed @entity66 . It is concluded that the addition of @entity786 alone is not adequate in the management of @entity2828 . @entity4316 in addition to @entity786 has improved the disease-free survival period significantly. The optimum dose of radiotherapy and its combination with other chemotherapeutic agents needs further trials to find the best and most suitable schedule.
