[A new infusion method for a XXXX analogue].

@entity1 @entity6027 @entity63 @entity1066 @entity4770 @entity158 @entity2827
BACKGROUND: Iloprost, a @entity4770 , is chemically stable and it has been successfully used by intravenous infusion in severe @entity63 . Usually Iloprost is diluted in 0.9% @entity2827 solution and infused intravenously for six hours each day for 28 days in hospital. METHODS: In the present study after the first three days of infusion with a traditional pump in hospital, a home pump has been utilised for the infusion of Iloprost at home. This device allows the continue infusion of Iloprost at a flow rate of 2 ml/h for six days, then the pump is filled with a new solution. The home pump consists of a protective shell in @entity6027 (10 x 12 cm), 270 ml of volume, inside there is a balloon reservoir (3 membranes) which is filled with Iloprost. The structure of Iloprost does not change into the home pump as evidenced by HPLC studies and its continue infusion allows plasmatic high levels of its active isomers during the 28 days of therapy. In 30 @entity1 , 25 @entity1 and 5 @entity1 (mean age 61 years) with Fontaine stage IIB (6), III (5) and IV (19) POAD Iloprost has been infused with the home pump. The follow-up period was 1 to 16 months. RESULTS: The results have shown 4 major amputations and 1 death, in 9 @entity1 complete @entity158 relief and @entity1066 , and in 6 @entity1 only improvement in relief of @entity158 and @entity1066 . CONCLUSIONS: All the @entity1 appreciated this system of infusion because they had a normal life; in addition it is less expensive because the @entity1 stay in hospital only 3 days.
