Toxicological screening of Daouri, a polyherbal formulation used in XXXX in the Central Region of Togo.

@entity1 @entity137 @entity1133 @entity1011 @entity35 @entity99 @entity493
ETHNOPHARMACOLOGICAL RELEVANCE: Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the @entity137 of individual plants. The present investigation aims to study the composition and potential @entity137 of Daouri used in @entity1 in the Kotokoli community. MATERIALS AND METHODS: Surveys were performed using a semi-structured questionnaire to determine the composition of Daouri. On the basis of these data collected, Standard Daouri was formulated, and its aqueous extract was orally administered at 300, 600 and 1200mg/kg to @entity35 for 28 days. On the 29th day, the @entity35 were sacrificed and their serum were analysed to evaluate @entity99 . RESULTS: Four categories of Daouri were collected. The plant combinations used in each Daouri formulation varied according to the pathological conditions, including the age of the @entity1 and the availability of each plant. The most plants cited in the four Daouri were Khaya senegalensis (Desv.) A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. _ Diels. Although there was an increase in the alkaline phosphatase concentration, different doses of the aqueous extract of Standard Daouri were not toxic after 28 days of administration. In addition, the concentrations of @entity493 transaminase, @entity1011 and @entity1133 were not different between the Daouri-treated and control groups. CONCLUSION: Daouri is plant combination used in @entity1 in the Kotokoli community as a part of African Traditional Medicine. Standard Daouri is not toxic in @entity35 .
