Anti-inflammatory liposomes have no impact on liver regeneration in XXXX .

@entity1 @entity32 @entity40679 @entity409 @entity619 @entity14997 @entity3929 @entity35 @entity99
INTRODUCTION: Surgical resection is the gold standard in treatment of @entity99 , giving the @entity1 the best chance to be cured. The liver has a unique capacity to regenerate. However, an inflammatory response occurs during resection, in part mediated by Kupffer cells, that influences the speed of regeneration. The aim of this study was to investigate the effect of a Kupffer cell targeted anti-inflammatory treatment on liver regeneration in @entity35 . METHODS: Two sets of animals, each including four groups of eight @entity35 , were included. Paired groups from each set received treatment with placebo, low dose @entity619 , high dose @entity619 or low dose anti- @entity40679 @entity619 . Subsequently, the @entity35 underwent 70% partial hepatectomy. The two sets were evaluated on postoperative day 2 or 5, respectively. Blood was drawn for circulating markers of @entity32 and @entity409 tissue was sampled for analysis of regeneration rate and proliferation index. RESULTS: The high dose @entity619 group had significantly lower body and liver weight than the placebo and anti- @entity40679 -dex groups. There were no differences in liver regeneration rates between groups. Hepatocyte proliferation was completed faster in the placebo group, although this was not significant. The anti- @entity40679 -dex group showed increased blood levels of albumin and @entity3929 aminotransferase and a diminished inflammatory response in terms of significantly reduced @entity14997 , a2-macroglobulin and Interleukine-6. CONCLUSION: Low dose @entity619 targeted to Kupffer cells does not affect histological liver cell regeneration after 70% hepatectomy in @entity35 , but reduces the inflammatory response judged by circulating markers of @entity32 .
