[Role of the stroma of the hematopoietic organs in the development of XXXX . Intramedullary regulation of granulomonocytopoiesis].

@entity981 @entity82 @entity3052 @entity1503 @entity236 @entity7173
Bone marrow trepanobiopsies were cultivated in the agar drop-liquid medium system. A total of 155 subjects with different @entity1503 and 31 controls were examined. It was shown that prolonged cultivation of trepanobiopsies makes it possible to functionally evaluate the stromal elements of the bone marrow. The whole medullary tissue is characterized by marked heterogeneity as regards its ability to synthesize humoral stimulants of granulomonocytopoiesis. The colony-stimulating ability (CSA) of this tissue combines the CSA of the hemopoietic and stromal cells. In @entity236 of varying degree, the function of the bone @entity236 is highly activated. The trepanobiopsy areas short of the hemopoietic tissue possess a higher ability to form a monolayer on the dish surface. During @entity3052 and @entity981 relapses, the ability of the bone @entity236 to synthesize the humoral stimulants is lowered, whereas the ability to form monolayers is less demonstrable. In diseases associated with the development of secondary @entity82 (CMF, CML, @entity7173 ), the bone @entity236 was discovered to be less capable of synthesizing the humoral stimulants, which provides evidence against the involvement of fibrous tissue in the formation of the total CSA of the bone marrow. It is assumed that fibroblasts and fatty cells are related histogenetically and that their proliferation is controlled by humoral factors.
