The impact of increasing dose on XXXX in @entity263 .

@entity1 @entity263 @entity5 @entity342 @entity1349
PURPOSE: To assess the impact of increasing dose on @entity1349 ( @entity1349 ) for @entity263 @entity1 . METHODS: Treatment data were obtained on more than 20,000 @entity1 in the National Oncology Data Alliance  , a proprietary database of merged @entity5 registries, who were treated for @entity263 with definitive radiotherapy between 1995 and 2006. Eligible @entity1 had complete data on total dose, T stage, use and timing of @entity342 deprivation therapy (ADT), and treatment start date (n   =   20,028). @entity1 with prior @entity5 were excluded. RESULTS: On multivariate analysis, dose, T stage, grade, marital status, age, and neoadjuvant ADT were significant predictors of @entity1349 . Hazard ratios for @entity1349 declined monotonically with increasing dose, reaching 0.63 (95  % Confidence Interval 0.53-0.76) at >= 80  Gy. On subset analysis, neoadjuvant ADT significantly improved @entity1349 in high risk @entity1 but was not significant in lower risk @entity1 . The dose response was maintained across all risk groups. Medical comorbidities were balanced across all dose strata and sensitivity analysis demonstrated that other prognostic factors were unlikely to explain the observed dose response. CONCLUSIONS: This study suggests that increasing dose significantly improves @entity1349 in @entity263 @entity1 treated with radiotherapy.
