Alterations in contrast medium-induced XXXX after bepridil in @entity1 with @entity453 .

@entity1 @entity12962 @entity8639 @entity301 @entity1009 @entity26 @entity450 @entity8633 @entity460 @entity453
The acute effects of an intravenous infusion of @entity8633 ( @entity12962 ) (4 mg . kg-1) on left ventricular (LV) hemodynamics, coronary sinus blood flow (CSBF), and myocardial metabolism were studied in eight @entity1 with @entity453 . In contrast with data previously reported with @entity460 channel blockers, @entity12962 induced an elevation in LV end-diastolic pressure from 12.0 +/- 7.1 to 20.1 +/- 7.2 mm Hg (mean +/- SD, p less than 0.001) and a fall in LV dp/dt max from 1339 +/- 302 to 1177 +/- 251 mm Hg . @entity8639 (p less than 0.01). This significant alteration in LV function is likely to be explained by the lack of effect on heart rate and aortic pressure observed after an acute intravenous infusion of @entity12962 . Myocardial @entity26 consumption (MVO2) increased from 448 +/- 272 to 498 +/- 273 mumol . @entity1009 (p less than 0.05) as did CSBF from 79.5 +/- 42.7 to 92.1 +/- 45.1 ml X @entity1009 (p less than 0.01). Lactate extraction fell from 0.33 +/- 0.17 to 0.15 +/- 0.17 (p less than 0.05). A contrast medium-induced @entity301 ( @entity450 ) evidenced an increased hyperemic volume from 9.5 +/- 3.6 to 12.1 +/- 4.5 ml/100 g LV (p less than 0.01) and @entity450 duration from 23.3 +/- 6.9 to 32.3 +/- 15.4 sec (p less than 0.05) after @entity12962 . However, the peak/resting CSBF ratio was blunted after @entity12962 from 1.74 +/- 0.18 to 1.61 +/- 0.12 (p less than 0.05), evidencing a net effect of @entity12962 on @entity450 .(ABSTRACT TRUNCATED AT 250 WORDS)
