Hawthorn extract for treating XXXX : meta-analysis of randomized trials.

@entity1 @entity712 @entity344 @entity1353
The aim of this meta-analysis was to assess the evidence from rigorous clinical trials of the use of hawthorn extract to treat @entity1 with @entity712 . We searched the literature using MEDLINE, EMBASE, the Cochrane Library, CINAHL, CISCOM, and AMED. Experts on and manufacturers of commercial preparations containing hawthorn extract were asked to contribute published and unpublished studies. There were no restrictions about the language of publication. Two reviewers independently performed the screening of studies, selection, validation, data extraction, and the assessment of methodological quality. To be included, studies were required to state that they were randomized, double-blind, and placebo controlled, and used hawthorn extract monopreparations. Thirteen trials met all inclusion criteria. In most of the studies, hawthorn was used as an adjunct to conventional treatment. Eight trials including 632 @entity1 with @entity712 (New York Heart Association classes I to III) provided data that were suitable for meta-analysis. For the physiologic outcome of maximal workload, treatment with hawthorn extract was more beneficial than placebo (weighted mean difference, 7 Watt; 95% confidence interval [CI]: 3 to 11 Watt; P < 0.01; n = 310 @entity1 ). The pressure-heart rate product also showed a beneficial decrease (weighted mean difference, -20; 95% CI: -32 to -8; n = 264 @entity1 ) with hawthorn treatment. Symptoms such as @entity1353 and fatigue improved significantly with hawthorn treatment as compared with placebo. Reported adverse events were infrequent, mild, and transient; they included @entity344 . In conclusion, these results suggest that there is a significant benefit from hawthorn extract as an adjunctive treatment for @entity712 .
