Effects of pinealectomy on the levels and the circadian rhythm of plasma @entity1255 in XXXX .

@entity1255 @entity2041 @entity2493 @entity2197 @entity35 @entity3562 @entity65
@entity3562 is an independent @entity65 factor. There are several factors including aging that contribute to the development of @entity3562 . Nevertheless, the exact mechanisms causing this condition are still debated. We hypothesize that the age-related decrease in @entity2493 levels may be consequential in @entity3562 . Recently, we found that plasma @entity1255 (Hcy) levels are increased in pinealectomized (PINX) @entity35 and @entity2493 reverses this increase. The aim of the present study was to determine if there is a circadian rhythm of plasma Hcy in @entity35 and to examine the effect of pinealectomy on this cycle. Plasma Hcy levels demonstrated a 24-hr rhythm with a peak at 02:00 hr and a nadir at 14:00 hr in both control and PINX @entity35 . Pinealectomy did not change the phase of the rhythm or the nocturnal elevation of plasma Hcy, but it did significantly increase mean plasma Hcy levels compared with those in controls and in @entity35 that were sham pinealectomized (sPINX) (P < 0.05). @entity2493 decreases plasma Hcy levels while causing an increase in total @entity2041 (tGSH). In conclusion, we speculate that decreasing levels of @entity2493 during aging lead to @entity3562 and a decrease in t @entity2197 and the latter may be one of the factors causing @entity3562 in the elderly population.
