The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among @entity1 with XXXX .

@entity1 @entity15 @entity66
OBJECTIVE: @entity66 ( @entity66 ) for @entity15 ( @entity15 ) can reduce relapses and delay progression; however, poor adherence and persistence with @entity66 can result in sub-optimal outcomes. The associations between @entity66 adherence and persistence and inpatient admissions and emergency room (ER) visits were investigated. METHODS: @entity1 with @entity15 who initiated a @entity66 in a US administrative claims database were followed for 1 year. Persistence to initiated @entity66 was measured as the time from @entity66 initiation to discontinuation (a gap of >60 days without drug 'on hand') or end of 1-year follow-up. Adherence to initiated @entity66 was measured during the persistent period and was operationalized as the medication possession ratio (MPR). @entity1 with an MPR <0.80 were considered non-adherent. Claims during the 1-year follow-up period were evaluated for the presence of an all-cause inpatient admission or an ER visit. Adjusted odds ratios (AORs) for inpatient admission or ER visit comparing persistent vs non-persistent and adherent vs non-adherent @entity1 were estimated using logistic regression models adjusted for @entity1 characteristics. RESULTS: The final sample included 16,218 @entity1 . During the 1-year follow-up period, 35.3% of @entity1 discontinued their initiated @entity66 and 13.9% were not adherent while on therapy. During that same period, 10.0% of @entity1 had an inpatient admission and 24.9% had an ER visit. The likelihoods of inpatient admission and ER visit were significantly decreased in persistent @entity1 (AOR [95% CI]   =   0.50 [0.45, 0.56] and 0.65 [0.60, 0.69], respectively) and in adherent @entity1 (AOR [95% CI]   =   0.83 [0.71, 0.97] and 0.86 [0.77, 0.95], respectively). CONCLUSIONS: Persistence and adherence with initiated @entity66 are associated with decreased likelihoods of inpatient admission or ER visit, which may translate to improved clinical outcomes.
