Preoperative serum CA 19-9 level as a predictive factor for recurrence after curative resection in XXXX .

@entity1 @entity1125 @entity1735
BACKGROUND: Complete surgical @entity1125 ( @entity1125 ) offers the only chance of cure; however, long-term survival remains very limited because of frequent recurrence after surgery. The purpose of our study was to evaluate whether the preoperative serum @entity1735 antigen (CA) 19-9 level could predict recurrence after curative resection of @entity1125 . METHODS: We performed a retrospective review of the medical records of @entity1 who were diagnosed with @entity1125 and underwent curative resection. The optimal cutoff value for the preoperative serum level of CA 19-9 that predicted recurrence was determined by a ROC curve. Preoperative and postoperative risk factors for recurrence were evaluated using log-rank test. RESULTS: A total of 101 @entity1 were eligible for this study. The optimal cutoff value of preoperative serum CA 19-9 level to predict recurrence was 55  U/mL. Forty-five @entity1 (44.6%) experienced recurrence after curative resection with a median follow-up period of 28.4  months. Recurrence occurred in 33 (61.1%) of 54 @entity1 with CA 19-9 levels >= 55  U/mL compared with only 12 (25.5%) of 47 @entity1 with CA 19-9 levels <55  U/mL. The recurrence rate was significantly higher in @entity1 with baseline CA 19-9 serum levels >= 55  U/mL (hazard ratio, 3.282; 95% confidence interval, 1.684-6.395; P  <  0.001). CONCLUSIONS: Elevated preoperative serum CA 19-9 was associated with a high risk of recurrence after curative resection of @entity1125 . Different treatment plans might be needed for @entity1 with @entity1125 and high serum levels of CA 19-9.
