Acute XXXX studies of Croton membranaceus root extract.

@entity286 @entity137 @entity1133 @entity1067 @entity648 @entity72838 @entity492 @entity2101 @entity493 @entity1011 @entity35 @entity1068
AIM OF THE STUDY: Croton membranaceus root and leaf extracts are used in the Bahamas to aromatize @entity286 , in Nigeria to improve digestion, and in Ghana, for @entity1067 . Despite claims of success there is paucity of information on its @entity137 . The aim of this study was to determine if Croton membranaceus has acute @entity137 properties. MATERIALS AND METHODS: Roots were air-dried in a solar dryer for one week before milling. The powder was extracted with 96% @entity1068 , freeze-dried and re-extracted with distilled water and freeze-dried. 15 male @entity35 (180-200 g) were divided equally into 2 treatment groups [low dose (LD) and @entity2101 ( @entity2101 )], plus a control group (C). LD and @entity2101 received 1500 and 3000 mg/kg b.wt. Croton membranaceus aqueous extract, respectively, one time and observed for 14 days. Haematological [Full Blood Count and haemoglobin (Hb)], biochemical [ @entity648 , @entity493 aminotransferase (ALA), @entity492 aminotransferase (AST), total protein, albumin, globulin, alkaline phosphatise (ALP), y-glutamyltranspetidase (GGT), @entity1133 , @entity1011 , @entity1011 kinase - Muscle and Brain (CK-MB), @entity1011 kinase - Total ( @entity72838 )] examinations were performed. RESULTS: Control group's CK-MB (5444  534 U/L) and LD group CK-MB (4014  1016 U/L) were significantly different (p<0.05). Control and the @entity2101 group CK-MB (3955  1135 U/L) were significantly different (p<0.05). Both LD and @entity2101 @entity72838 levels (697  197U/L and 732  203 U/L, respectively), were lower than the control (1139  220 U/L) at 48 h and 14 days (p<0.05, p<0.05, respectively). y-GT levels of the @entity2101 group was 4.8  0.4 U/L compared to the Control group value of 0.9  0.2 U/L (p<0.05). CONCLUSIONS: Taking all factors into consideration, Croton membranaceus ingestion does not produce general acute @entity137 . However, its @entity1011 kinase lowering ability could be explored.
