Constitutive expression of the low-affinity neurotrophin receptor and changes during axotomy-induced XXXX of sensory neurones in the neonatal @entity35 dorsal root ganglion.

@entity39 @entity5 @entity11451 @entity35 @entity204
Sensory neurones in the dorsal root ganglion (DRG) of the neonatal @entity35 express the 75-kDa low-affinity neurotrophin receptor ( @entity11451 ) and these neurones degenerate rapidly after axotomy. @entity11451 belongs to the @entity5 @entity39 factor superfamily, several members of which have a role in cell @entity204 and it is constitutively expressed within a subpopulation of DRG neurones. @entity11451 has been implicated in mediating the degeneration of these neurones after axotomy. In this study, we characterize the expression of @entity11451 in sensory neurones of the newborn @entity35 DRG using immunohistochemistry. Furthermore, we investigate the change in constitutive expression pattern of @entity11451 in these neurones following axotomy. In the C7 and C8 DRG of the newborn @entity35 , @entity11451 is expressed in approximately 70% of DRG neurones. Those expressing @entity11451 can be classified into subpopulations with moderate or intense @entity11451 expression, each present in approximately equal proportions. Whilst @entity11451 expression is observed in neurones throughout the entire neuronal diameter range, a correlation exists between neuronal diameter and @entity11451 expression intensity. We also found that the most vulnerable population following axotomy were those sensory neurones which constitutively express the highest levels of @entity11451 , i.e. the large-diameter neurones.
