A high- @entity3106 diet does not impair XXXX tolerance and insulin sensitivity in healthy women.

@entity3106 @entity3952 @entity1003 @entity1718 @entity413
Results in epidemiological and experimental studies suggest that a diet rich in saturated fat may affect insulin sensitivity. However, no published data are available on the effect of @entity3106 in this respect. Therefore, we examined the effects of a high- @entity3106 diet and a high- @entity3952 diet on @entity413 metabolism, serum lipids and lipoproteins, and @entity1003 factors in 15 healthy female subjects. Subjects followed the two experimental diets for 4 weeks according to a randomized crossover design. Both experimental diet periods were preceded by consumption of a baseline diet for 2 weeks. The diets provided 36% of energy (E%) as fat. In the experimental diets, 5 E% stearic or @entity3952 was substituted for 5 E% of @entity1718 in the baseline diet. After the experimental diets, no differences were found in the insulin sensitivity index (mean+/-SEM, 5.4+/-1.9 v 5.2+/-1.6 x 10(-4) min(-1) x microU(-1) x mL(-1), nonsignificant [NS]), @entity413 effectiveness (0.026+/-0.006 v 0.026+/-0.003 min(-1), NS), or first-phase insulin reaction ([FPIR] 368+/-57 v 374+/-66 mU/L x min, NS). The concentration of serum lipids and lipoproteins and @entity1003 factors did not differ after the diet periods. In conclusion, a diet rich in @entity3106 did not deteriorate @entity413 tolerance or insulin action in young healthy female subjects as compared with a diet rich in @entity3952 .
