Is @entity842 involved in cutaneous vasodilation during body heating in XXXX ?

@entity1 @entity1617 @entity7293 @entity842 @entity934
The neurotransmitter responsible for neurogenic vasodilation in @entity1 skin during body heating is unknown. We sought to determine whether the vasodilating substance @entity842 (NO) is involved in this phenomenon. Six subjects were heated for 50 min by use of a water-perfused suit while forearm blood flow (FBF) was measured with plethysmography and skin blood flow (SkBF) was measured by the laser-Doppler method in both arms. In one forearm, @entity7293 ( @entity7293 ), an NO synthase blocker, was infused into the brachial artery. Bolus doses of @entity7293 (< or = 4 mg/min) for 5 min were given to blunt NO-mediated vasodilator responses to @entity934 ( @entity1617 , 64 micrograms/min). A continuous infusion of @entity7293 (< or = 1.0 mg/min) was used during body heating to maintain NO synthase blockade. In the forearm receiving @entity7293 , FBF was 1.8 +/- 0.3 ml.100 ml-1.min-1 before drug infusion and rose to 9.5 +/- 1.3 ml.100 ml-1.min-1 with @entity1617 . After @entity7293 infusion, FBF was 1.3 +/- 0.2 ml.100 ml-1.min-1 and rose to 2.6 +/- 0.4 ml.100 ml-1.min-1 with @entity1617 (both P < 0.05 vs. pre- @entity7293 ). Similar changes in SkBF were seen with @entity1617 and @entity7293 , confirming that the drugs reached cutaneous vessels. With body heating, oral temperature increased by 1.2 degrees C, heart rate increased by 34 beats/min, and mean arterial pressure remained constant at approximately 75 mmHg. FBF in the treated forearm rose to 11.5 +/- 2.1 vs. 12.6 +/- 1.7 ml.100 ml-1.min-1 in the control forearm (P > 0.05, control vs. treated response).(ABSTRACT TRUNCATED AT 250 WORDS)
