Specific adverse effects of XXXX - A true-to-life monotherapy study.

@entity1 @entity4677 @entity410 @entity308 @entity25 @entity146 @entity1092 @entity2049 @entity2146 @entity302 @entity2414 @entity2812 @entity734
BACKGROUND: In patients taking @entity734 ( @entity734 ) for @entity302 , adverse effects (AEs) often lead to unfavorable quality of life, impaired adherence, and, eventually, discontinuation of pharmacological treatment. In a true-to-life sample of subjects from our academic @entity302 outpatient clinic, we aimed to identify predictors for overall high AE burden and for specific AEs focusing on @entity1 on monotherapy. METHODS: All @entity1 >= 16years of age with @entity302 for >= 12months were routinely asked to complete the Liverpool Adverse Event Profile (LAEP) just before their appointment. @entity302 , and treatment variables were derived from our comprehensive outpatient database. RESULTS: Out of 841 @entity1 , 438 (61% female, mean age: 44.7  17.1years) on monotherapy were included in this study. @entity4677 (n=151), @entity2812 (n=167), @entity1092 (n=73), or controlled-release @entity2049 (n=47) were the most commonly used @entity734 ( @entity734 ). Independent predictors for general high AE burden (LAEP score>= 45) were duration of @entity302 , lack of 12-month @entity410 freedom, and @entity302 , but none of the four individual @entity734 . The most frequent LAEP-defined specific AEs were @entity25 , difficulty concentrating, @entity2414 . The three most frequent independent predictors for each of the 19 AEs were lack of 12-month @entity410 freedom (13/19 AEs), individual AED (7/19 AEs), and @entity302 (6/19 AEs). @entity4677 was independently associated with anger/ @entity146 , nervousness/ @entity2146 , upset stomach, @entity308 , and @entity25 ; @entity2812 with nervousness/ @entity2146 , upset stomach, and difficulty concentrating; and @entity1092 with upset stomach and shaky hands. CONCLUSION: Individual @entity734 independently predicted some specific AEs, but not overall high AE burden. Our findings may help to characterize @entity1 with @entity302 who are at high risk for specific AEs. Dose reduction or change to another AED may reduce LAEP score and potential nonadherence.
