Identification and expression analysis of 26 oncogenes of the receptor XXXX kinase family in @entity4576 after @entity2348 .

@entity295 @entity5 @entity2348 @entity4576 @entity519 @entity13195 @entity4149
Receptor @entity4149 kinases (RTKs) are high-affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. RTKs are not only key regulators of normal cellular processes, but are also involved in the progression of many types of @entity5 , and responses to various biotic and abiotic stresses. Catfish is a primary aquaculture species in the United States, while its industry is drastically hindered by several major diseases including enteric @entity295 of catfish (ESC) that is caused by @entity13195 . Disease outbreaks are often accompanied by @entity519 stress, which affects the performance and survival of fish by reducing disease resistance. In this study, we identified 26 RTK oncogenes in the @entity4576 genome, and determined their expression profiles after ESC infection and @entity519 stress. The 26 RTK genes were divided into four subfamilies according to phylogenetic analysis, including TIE (2 genes), ErbB (6 genes), EPH (14 genes), and INSR (4 genes). All identified RTKs possess a similar molecular architecture including ligand-binding domains, a single transmembrane helix and a cytoplasmic region, which suggests that these genes could play conserved biological roles. The expression analysis revealed that eight RTKs were significantly regulated after @entity2348 , with dramatic induction of insulin receptor genes including INSRb, IGF1Ra, and IGF1Rb. Upon @entity519 stress, EPHB3a, EGFR, ErbB4b, and IGF1Rb were expressed at higher levels in the tolerant catfish, while EPHA2a, EPHA2, TIE1 and INSRa were expressed at higher levels in the intolerant catfish. These results suggested the involvement of RTKs in immune responses and @entity519 tolerance.
