A population-based study of malignant XXXX in Ontario.

@entity1 @entity788 @entity5 @entity1582 @entity1745
DESIGN: Population-based cohort study. BACKGROUND: Malignant @entity1745 (MSCC) has long been recognized as an important complication of @entity5 , but its incidence is unknown. OBJECTIVES: To describe the incidence, the management, and the outcome of MSCC in the @entity5 population of the Canadian province of Ontario. METHODS: Episodes of MSCC, and treatments used for each episode, were identified by linking electronic hospital separation records and @entity5 centre records to Ontario's population-based @entity5 registry. The cumulative frequency of MSCC in the last 5 years of life was described in the 121435 @entity1 who died of @entity5 in Ontario between 1990 and 1995. Survival after the first episode of MSCC, and duration of hospitalization with MSCC, was described. RESULTS: The cumulative probability of experiencing at least one episode of MSCC in the 5 years preceding death from @entity5 was 2.5% overall, and ranged from 0.2% in @entity788 to 7.9% in @entity1582 . Overall, 60.2% of first episodes of MSCC were treated with primary radiotherapy, and 16.1% with surgery +/- postoperative radiotherapy, while in the remaining 23.7%, there was no record of radiotherapy or surgery. Overall, the median survival following the first episode of MSCC was 2.9 months. The diagnosis of MSCC was associated with a doubling of the time spent in hospital in the last year of life. CONCLUSION: MSCC is a fairly common occurrence among @entity1 dying of @entity5 . There is a 40-fold variation in the cumulative incidence of MSCC among different types of @entity5 .
