The influence of lung volume reduction with intrabronchial valves on the quality of life of @entity1 with heterogeneous XXXX - a prospective study.

@entity1 @entity286 @entity8015 @entity2415 @entity1030
INTRODUCTION: A heterogeneous @entity2415 is one of the most severe forms of @entity1030 ( @entity1030 ). In some cases, besides the standard pharmacotherapy, a new treatment option of @entity2415 can be used - bronchoscopic lung volume reduction (BLVR) with the use of intrabronchial valves. OBJECTIVES: To examine the health-related quality of life (HRQoL) of @entity1 with severe @entity2415 after intrabronchial valve ( @entity8015 ) implantation for the treatment of one lung. MATERIAL AND METHODS: From 2011 to 2013 a single centre prospective observational study was performed. The study assessed the effect of the therapeutic BLVR intervention, measured by St. George Respiratory Questionnaire (SGRQ). A statistical analysis by use of Wilcoxon test for dependent variables was performed. RESULTS: Twenty @entity1 were enrolled to the study (mean age 63    10 years), all ex-smokers with @entity286 exposure 38    11.3 packyears. After 3 months of @entity8015 treatment the average SGRQ score improved significantly in total (-12.8; p < 0.001) and in domains and the differences were for: "symptoms" (-8.5; p < 0.001), "activity" (-13.9; p < 0.001) and "influence on life"(-13.5; p < 0.002). CONCLUSIONS: The presented study revealed a significant improvement of the quality in the life measured by SGRQ after @entity8015 treatment for heterogeneous @entity2415 . For the first time our study showed the significant improvement of all three domains of SGRQ after @entity8015 treatment.
