Moderate @entity3747 due to normal serum @entity10692 levels in an asymptomatic kindred with XXXX .

@entity1 @entity3747 @entity851 @entity10692 @entity261 @entity14645 @entity27935 @entity460 @entity1011 @entity1098 @entity560
@entity261 was diagnosed in nine members of a kindred of three generations. This study investigated why these @entity1 were asymptomatic and without @entity851 , in contrast to the common presentation of @entity261 . In the @entity14645 subjects, serum @entity460 level was 7.4 +/- 0.8 mg/dl (mean +/- SD) and ionized serum @entity460 level was 3.48 +/- 0.21 mg/dl. Immunoreactive parathyroid hormone values were inappropriately low. Injection of @entity1098 in one @entity1 lowered ionized @entity460 levels, but immunoreactive parathyroid hormone values did not rise. Serum levels of @entity10692 and other @entity560 metabolites were normal or elevated and substantially higher than in other @entity261 states. The normally observed positive correlation between the fasting urinary @entity460 / @entity1011 ratio and serum @entity10692 that reflects the dependence of net bone resorption on @entity10692 was upheld in @entity261 @entity1 . It is proposed that the subjects with @entity27935 in this kindred had moderate asymptomatic @entity3747 without @entity851 because normal or elevated serum @entity10692 levels enhanced intestinal @entity460 absorption. This may represent one point in the spectrum of @entity261 . Alternately, both the moderate degree of @entity3747 and the normal serum calcitriol values could have been related to mild, partial @entity261 , which could have been inherited in this kindred.
