The effects of perioperative XXXX administration on convalescence and wound healing.

@entity1 @entity130 @entity5 @entity1151 @entity281 @entity1820 @entity65 @entity236 @entity413 @entity1487
Administration of chemotherapy is delayed by most clinicians until complete recovery from surgery because it is generally feared that cytotoxic drugs impair wound healing, reduce resistance against @entity281 , and may hinder the recovery process. However, clinical experience is lacking. This clinical study examines the effect of perioperative administration of @entity1487 on the healing of wounds and intestinal anastomoses and the recovery process in general. Forty @entity1 with advanced @entity1820 entered the study. Intravenous bolus administration of 0.5 g of @entity1487 was started during surgery. The @entity1 underwent a variety of abdominal operations for palliation or cure. A total of 22 gastric and enteric anastomoses were performed. One half gram of @entity1487 diluted in 150 mL of 5% @entity413 solution was given intravenously over one hour daily for ten days postoperatively. The @entity1 were carefully evaluated for any alteration in the postoperative recovery. Thirty-eight of the 40 @entity1 received the full course of @entity1487 . Twenty-one @entity1 had an uneventful postoperative course. Eighteen had mild to moderate @entity65 unrelated to @entity1487 administration. One @entity1 died of @entity1151 16 days after abdominoperineal resection. Surgical wounds healed without complications in 37 @entity1 . One case of @entity130 occurred after sigmoidectomy. Two @entity1 developed wound infections that healed secondarily. All 22 @entity1 with anastomoses recovered without any evidence of leakage. Colostomies and gastrostomies functioned as anticipated. Side effects attributed to @entity1487 appeared in seven of the @entity1 ; in only two of the @entity1 were complications life-threatening, involving @entity236 . All @entity1 recovered after discontinuation of @entity1487 therapy and with supportive treatment. On the whole, the course of recovery of this group was no different than expected from @entity1 with advanced @entity5 who were undergoing extensive surgery. Based on this study, it seems that @entity1487 administration during and immediately after surgery has no deleterious effect on wound healing and recovery.
