[Oral XXXX --an overview].

@entity1697 @entity2345 @entity5 @entity2640 @entity9821 @entity189 @entity2173 @entity1282 @entity1613 @entity8619
@entity1613 are defined as a generalized state associated with a significantly increased risk of @entity5 . For the oral and perioral region, @entity1282 , @entity8619 ( @entity8619 ), @entity2345 ( @entity2345 ), syphilis, @entity9821 , @entity2173 as well as @entity2640 play a role as @entity1613 . The number of published cases of oral or perioral malignant transformation for some of these diseases is small. In addition, @entity1697 associated with syphilis are of historical interest, although publications in the 1990s still reported positive serology of syphilis and @entity189 of the tongue. @entity8619 is still controversially discussed as to its premalignant nature. Transformation rates have been reported between 0% and 5.6%. Recent prospective studies have revealed that possibly oral lichenoid reactions (OLR) are more likely to form the basis of malignant transformation as compared to the classic @entity8619 . The differentiation between @entity8619 and OLR is difficult both from clinical and histopathological aspects. The second most important @entity1613 is @entity2345 , which is caused by betel quid chewing. @entity2345 is most prevalent in South and Southeast Asia. The transformation rate is as high as 7.6% making @entity2345 one of the most important @entity1613 of the oral region.
