Visual loss in XXXX of childhood.

@entity1 @entity32 @entity2194 @entity231 @entity4 @entity1596 @entity262 @entity726 @entity4932 @entity1939 @entity6519 @entity3251
AIMS: To investigate the manifestations and severity of @entity1596 in @entity1 and to identify the risk and specific causes of @entity1939 in this population. METHODS: Retrospective study of data of 123 consecutive @entity1 examined with active @entity1596 and the onset of @entity2194 before the age of 16 years. Numerous variables were assessed including age and sex distribution, laboratory data, the presence of @entity262 , onset and course of @entity32 , clinical features and complications, therapeutic strategies and their outcomes, final visual acuity, and characteristics associated with poor visual outcome. RESULTS: @entity262 was observed in 36/123 @entity1 (29%), with @entity4932 being the most frequent (25/123, 20%). @entity3251 was diagnosed in 12/23 @entity1 with posterior @entity1596 (52%; 10% of all with @entity1596 ). @entity32 required systemic drugs in 57 (46%) @entity1 . Ocular complications were observed in 93 @entity1 (76%), of which the most common was @entity231 (43/123, 35%). Intraocular surgery was required in 35 @entity1 (28%; in total 75 procedures). Three @entity1 (2%) became @entity1939 and an additional 20/121 (17%) had one @entity1939 caused by @entity1596 . The most frequent causes of @entity1939 were @entity6519 in the macular area and @entity726 in contrast with @entity4 ( @entity4 ) in adults. CONCLUSIONS: @entity1596 in childhood is a potentially blinding disease, in the majority of @entity1 characterised by a chronic course and a high complication rate.
