Comparison between familial and nonfamilial XXXX in France.

@entity1 @entity321 @entity5 @entity73168 @entity320
BACKGROUND AND DESIGN: Five percent to 10% of @entity320 ( @entity320 ) occur in a familial setting. Clinical, epidemiologic, and genetic studies of familial @entity73168 in different regions of the world have led to various results. To assess the characteristics of familial @entity73168 in France, the clinical, histologic, and epidemiologic characteristics of 295 @entity1 with @entity73168 were recorded, and a comprehensive familial investigation was performed for each case. @entity1 with a family history of @entity73168 were compared with nonfamilial cases. RESULTS: @entity320 occurred as a @entity5 in 22 (8%) of 295 @entity1 . Among the multiple variables studied, those significantly associated with the familial occurrence of @entity73168 were red hair, inability to tan, and presence of clinically atypical moles. When these variables were considered together in a multivariate analysis, only the association with red hair (P = .001) and atypical moles (P < .05) remained significant. In addition, the @entity1 with @entity321 exhibited the following tendencies: a younger age at diagnosis, a higher number of moles, and the development of multiple primary @entity320 , but these results did not reach statistical significance. Factors relating to UV light exposure, histologic features of @entity73168 , course of the disease, and occurrence of @entity5 showed a similar distribution between familial and nonfamilial cases. CONCLUSION: A familial investigation should be performed for each @entity1 with @entity73168 in France, particularly when he or she exhibits phenotypic risk factors for @entity73168 such as red hair and atypical moles.
