Effects of total parenteral nutrition on lipid metabolism in XXXX .

@entity407 @entity1375 @entity1560 @entity52927 @entity13688 @entity1674 @entity165 @entity35 @entity8856
BACKGROUND: The pathophysiologic mechanisms behind the development of @entity1560 during total parenteral nutrition (TPN) and the possible relationship to alterations of @entity13688 activities in different tissues are not fully known. It is also unknown whether continuous and discontinuous administration of @entity8856 affect lipid metabolism differently. METHODS: TPN, including 8.4 g of @entity1674 per kilogram per day, was given for 10 days to two groups of male @entity35 that received the infusions discontinuously and continuously, respectively. Freely fed @entity35 were used as controls. RESULTS: TPN led to @entity407 and accumulation of @entity1674 in the liver. High-density lipoproteins were enriched in @entity1674 , whereas high-density lipoprotein @entity165 and phospholipid levels were low. The activities of @entity52927 were markedly decreased, and @entity13688 activities in adipose tissue and in cardiac muscle were both up-regulated. The increased levels of @entity165 and phospholipids in the serum of TPN animals were more pronounced after discontinuous administration. CONCLUSIONS: TPN including lipids interferes with the normal regulation of lipid metabolism. Although the mechanisms remain obscure, the elevation of @entity13688 activities seems functionally important to accommodate the increased input of @entity1674 during TPN. Possibly, the observed alterations in lipase activities may be attributed to a state of @entity1375 .
