Prognostic significance of biomarkers of diffuse large XXXX .

@entity1 @entity588 @entity986 @entity10807 @entity20630 @entity2282 @entity4042 @entity1892
UNASSIGNED: 9639 Background: Although @entity1892 ( @entity1892 ) is usually considered as a specific disease entity, findings suggest diversity rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), is useful in assessing overall prognosis with some reserve. It is likely that the prognostic assessment of @entity1 with @entity1892 might be improved by using biological features. METHODS: To determine the clinical significance and prognostic value of biological markers expressed in @entity1892 , we retrospectively studied 26 @entity1 diagnosed as de novo @entity1892 at Chungnam National University Hospital.Immunohistochemical studies were performed with @entity2282 , @entity4042 , @entity20630 , @entity588 , @entity986 , @entity10807 , and MHC-II, Ki-67 antibodies on archival pathology specimens. Two immunophenotypic patterns were distinguished according to the pattern of differentiation: germinal center (GC; @entity2282  / @entity4042 +/ @entity20630 -) or post-germinal center (pGC; @entity2282  / @entity4042  / @entity20630 +)type. RESULTS: The median age was 56 (range;37   69). 17 @entity1 (65.4%) were male. 5 @entity1 (19.2%) had 'B' symptoms. 11 @entity1 (42.3%) had the elevated LDH level. 5 @entity1 (19.2%) had bulky disease. After a median follow up duration of 48 months, the median survival time was 44 months with a range of 1   100+ months. 5-year overall survival rate was 32% by Kaplan-Meier method. The clinical factors affecting survival were serum LDH level, stage, B Symptom, bulky disease, stage at diagnosis. The only immunologic marker affecting survival was @entity588 . In @entity1 with the same IPI scores, @entity588 positive @entity1 had lower survival.(p = 0.002 ) The germinal center like type had better survival than post-germinal center like type but had no statistical significance. .(p = 0.064 ) Conclusion: Immunohistochemical profiles of @entity1892 maybe useful in predicting survival, especially @entity588 expression. Germinal center type had better survival than post-Germinal center like type without statistical significance. Large scale study in more @entity1 are warranted. No significant financial relationships to disclose.
