[Effects of @entity3971 and related compounds on erythrocytes and hepatocytes from @entity35 and XXXX -liposomes].

@entity308 @entity607 @entity4749 @entity35 @entity3971 @entity4748 @entity12682 @entity2142 @entity4747
The effects of @entity3971 , @entity12682 and @entity607 on erythrocytes, hepatocytes, @entity4747 ( @entity4748 )-liposomes and surface tension were studied at various concentrations. @entity3971 at 10 mM caused a slight inhibition of @entity2142 in @entity35 erythrocytes. @entity12682 at 4 and 10 mM and @entity607 at 0.6 to 10 mM caused a significant inhibition of @entity2142 . In the enzyme leakage from isolated @entity35 hepatocytes, @entity3971 at 0.001 to 0.4 mM and 2 to 10 mM, @entity12682 at 2 to 10 mM and @entity607 at 0.001 to 4 mM caused an inhibition in GOT leakage. The leakage of @entity4749 from hepatocytes was inhibited by @entity3971 at 0.4 to 10 mM, @entity12682 at 2 to 10 mM, and @entity607 at 0.001 to 4 mM. @entity607 at 10 mM caused increases in GOT and @entity4749 leakage. The inhibition of @entity3971 and @entity607 on the LDH leakage in hepatocytes were observed at a concentration of 0.001 mM and 0.1 to 1 mM, respectively. @entity12682 or @entity607 at 10 mM caused an increase in LDH leakage. Phase-transition temperature of @entity4748 -liposomes was @entity308 by @entity3971 and @entity607 at 1 to 10 mM and by @entity12682 at 5 and 10 mM. @entity12682 at 1 and 10 mM and @entity607 at 10 mM caused a @entity308 of surface tension, but @entity3971 caused no change in surface tension. The order of effects on erythrocyte, hepatocyte and @entity4748 -liposome membranes was @entity607 greater than @entity3971 greater than or equal to @entity12682 . In the present study, @entity3971 and its related compound showed a positive correlation between their effects on various membranes and germicidal effects as evaluated by the @entity3971 coefficient, but the effects were not related to a @entity308 of surface tension.
