The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on XXXX .

@entity1 @entity753 @entity270 @entity1674 @entity904 @entity165
Lipid apheresis (extracorporeal lipoprotein elimination) is administered to @entity1 with @entity753 who fail to respond to standard therapy. The nature of the treatment process raises the suspicion that it decreases not only @entity165 but also antioxidants. A group of 12 @entity1 (average age 47  17 y, 4 homozygous and 8 heterozygous individuals) with @entity753 treated by LDL-apheresis or rheohaemapheresis for 3-12 y was included in the study. In addition to @entity165 and @entity1674 levels, @entity270 and @entity904 and also other markers of antioxidant activity were investigated. Nevertheless, the most important determined parameter was the @entity270 / @entity165 ratio in serum and lipoproteins. The results indicate that both extracorporeal elimination methods are effective and suitable ways to treat severe @entity753 , as the LDL fraction of @entity165 decreased by approximately 77% and 66% following LDL-apheresis and rheohaemapheresis, respectively. In addition, the serum @entity270 decreased by 54% and 57% and the decrease of the serum @entity904 was approximately 20%. However, the main marker of antioxidant capacity, @entity270 / @entity165 ratio, in the serum, VLDL and LDL significantly increased. The increase of @entity270 levels in the erythrocyte membranes of 2% following LDL-apheresis and a significant increase of 4% following rheohaemapheresis were confirmed. The presented results indicate that LDL-apheresis and rheohaemapheresis can be considered to be safe procedures according to the antioxidant capacity of the serum, VLDL and LDL lipoprotein fractions and the erythrocyte membrane.
