[ XXXX transport into the bile, especially in the intra- and postoperative periods].

@entity1 @entity6279 @entity1087 @entity1448 @entity6278
Using 13 @entity1 undergoing operation of the bile duct, @entity6278 ( @entity6279 ) transport into the bile and the gallbladder tissue was investigated. One gram of @entity6279 was administered through drip infusion over 30 minutes every 12 hours. @entity6279 concentration in bile was measured for samples surgically collected about 103 minutes (75-141 minutes) after the start of @entity6279 administration. @entity6279 concentrations in bile samples collected from gallbladder were found to be as high as 326.6 +/- 432.3 micrograms/ml in @entity1 with neither @entity1087 nor @entity1448 , indicating sufficient @entity6279 transport. When @entity1448 were present, @entity6279 concentrations were very low, or moderately @entity1087 was also present. Changes in @entity6279 concentration were then measured over 6 hours after administration in @entity1 with an external biliary fistula every other day for a period of 7 days, from the first postoperation day. As for horal changes, @entity6279 concentration reached its peak in 2 hours after the start of administration in most cases. Maximum @entity6279 concentrations in @entity1 without @entity1087 were high, ranging from 313.3 to 1,232.3 micrograms/ml (mean, 641.2 micrograms/ml), and @entity6279 was found at 4.0-76.6 micrograms/ml (mean, 37.4 micrograms/ml), even after 6 hours. As for diurnal changes, @entity6279 was determined to be sufficiently transported into the bile from the first postoperation day. Although @entity6279 concentrations tended to be lower on the fifth postoperation day than on other days, there was no statistical significance in differences in daily concentrations examined. @entity6279 concentrations in gallbladder tissues were determined to be 22.7 4/- 32.1 micrograms/g, and they decreased over time exponentially.
