Multicentre prospective controlled study of XXXX and @entity2513 . Groupe d'Etude de l'Oesophage de Barrett.

@entity1 @entity652 @entity355 @entity548 @entity14 @entity2513 @entity694 @entity1744
Previous studies have suggested that @entity1 with @entity355 may be at increased risk of @entity14 , though the association is disputed. In a multicentre prospective study we compared the prevalence of @entity2513 in @entity1 with @entity355 and controls. @entity355 @entity1 (n = 104) had histological confirmation of columnar epithelium extending more than 3 cm above the gastro-oesophageal junction. The 537 controls were @entity1 with symptoms suggesting @entity1744 . No @entity1 had a personal history of @entity694 . Each @entity1 underwent colonoscopy. Histologically proven @entity652 were found in 26 Barrett's @entity1 (25%) and 75 controls (14%). Three @entity14 were discovered in each group. The prevalence of @entity652 was greater in the @entity355 group than in the control group (p < 0.01) but the relation became non-significant after adjustment for age and sex and control for other known risk factors by a logistic regression model (odds ratio 1.4 [0.7-2.7]). The relative risk of @entity652 was significantly higher in @entity1 older than 59 than in younger @entity1 (2.2 [1.3-3.5]) and in @entity1 than in @entity1 (3.4 [2.0-5.7]). Other factors contributing significantly to the risk of @entity652 were a family history of @entity14 (2.3 [1.1-4.8]), @entity548 (2.1 [1.1-3.9]), previous colonic investigation (0.3 [0.1-0.7]), and complete as opposed to partial colonoscopy (6.4 [0.8-48.3]). We conclude that @entity355 is not an independent risk factor for @entity14 and, therefore, is not, in itself an indication for colorectal screening.
