Baseline dietary fiber intake and XXXX in the @entity3505 bran fiber randomized trial.

@entity3505 @entity1 @entity2513 @entity652
BACKGROUND: The @entity3505 Bran Fiber (WBF) trial was a double-blind, high-fiber versus low-fiber phase III intervention trial in which @entity1 were randomly assigned to receive a cereal fiber supplement of either 2.0 g/day or 13.5 g/day to assess whether a high-fiber supplement could decrease risk of recurrent @entity2513 . Although no effect of the supplement on polyp recurrence was observed, @entity1 consumed a baseline average of 17.5 grams of fiber per day, which may have been sufficient to protect against @entity652 . Therefore, we examined whether baseline fiber intake affected @entity2513 or modified the effect of treatment group in the WBF trial @entity1 . METHODS: Quartiles of baseline fiber intake were calculated on the basis of the distribution in the study population. Odds ratios (ORs) for @entity652 were calculated using the lowest quartile of fiber intake as the reference. The effect of fiber from specific food sources on @entity652 was also assessed. All statistical tests were two-sided. RESULTS: Adjusted ORs (95% confidence intervals) for @entity652 were 0.79 (0.56 to 1.12), 0.76 (0.54 to 1.08), and 0.83 (0.57 to 1.19) for the second, third, and fourth quartiles, respectively. Fiber from the three primary food sources (fruits; breads, cereals and crackers; and vegetables) had no appreciable effect on @entity652 . Baseline fiber intake also had little effect on @entity652 when the population was stratified by treatment group. In addition, there was no interaction between treatment group and quartile of baseline fiber intake. CONCLUSIONS: No association was found between amount of fiber consumed at baseline and @entity652 in the WBF trial @entity1 . The baseline fiber intake, whether considered as a whole or from specific sources, did not modify the effect of treatment group.
