Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for XXXX .

@entity565 @entity2490 @entity402 @entity56 @entity484
BACKGROUND: WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent @entity565 and @entity56 is conflicting. We examined whether following recommended breastfeeding guidelines alters the long-term risks of @entity565 , @entity484 , @entity2490 or @entity402 . METHODS: The effect of nonexclusive (0, >0-6, >6 months) and exclusive breastfeeding (0, >0-4, >4 months) on repeated measures of @entity565 (10, 18 years), @entity484 , @entity2490 , and @entity402 (1-or-2, 4, 10, 18 years) risks was estimated in the IoW cohort (n = 1456) using log-linear models with generalized estimating equations. The Food Allergy and Intolerance Research (FAIR) cohort (n = 988), also from the IoW, was examined to replicate results. RESULTS: Breastfeeding (any or exclusive) had no effect on @entity565 and @entity56 in the IoW cohort. In the FAIR cohort, any breastfeeding for >0-6 months protected against @entity565 at 10 years (RR = 0.50, 95% CI = 0.32-0.79, P = 0.003), but not other outcomes, whilst exclusive breastfeeding for >4 months protected against repeated @entity2490 (RR = 0.36, 95% CI = 0.18-0.71, P = 0.003). Longer breastfeeding was protective against late-onset wheeze in the IoW cohort. CONCLUSION: The protective effects of nonexclusive and exclusive breastfeeding against long-term allergic outcomes were inconsistent between these colocated cohorts, agreeing with previous observations of heterogeneous effects. Although breastfeeding should be recommended for other health benefits, following breastfeeding guidelines did not appear to afford a consistent protection against long-term @entity565 , @entity484 , @entity2490 or @entity402 . Further research is needed into the long-term effects of breastfeeding on @entity56 .
