Impact of Exposure Uncertainty on the Association between XXXX and Preeclampsia in the C8 Health Project Population.

@entity1 @entity2206 @entity2207 @entity1468
BACKGROUND: Uncertainty in exposure estimates from models can result in exposure measurement error and can potentially affect the validity of epidemiological studies. We recently used a suite of environmental models and an integrated exposure and pharmacokinetic model to estimate individual @entity2206 ( @entity2207 ) serum concentrations and assess the association with @entity1468 from 1990 through 2006 for the C8 Health Project @entity1 . OBJECTIVES: The aims of the current study are to evaluate impact of uncertainty in estimated @entity2207 drinking-water concentrations on estimated serum concentrations and their reported epidemiological association with @entity1468 . METHODS: For each individual public water district, we used Monte Carlo simulations to vary the year-by-year @entity2207 drinking-water concentration by randomly sampling from lognormal distributions for random error in the yearly public water district @entity2207 concentrations, systematic error specific to each water district, and global systematic error in the release assessment (using the estimated concentrations from the original fate and transport model as medians and a range of 2-, 5-, and 10-fold uncertainty). RESULTS: Uncertainty in @entity2207 water concentrations could cause major changes in estimated serum @entity2207 concentrations among @entity1 . However, there is relatively little impact on the resulting epidemiological association in our simulations. The contribution of exposure uncertainty to the total uncertainty (including regression parameter variance) ranged from 5% to 31%, and bias was negligible. CONCLUSIONS: We found that correlated exposure uncertainty can substantially change estimated @entity2207 serum concentrations, but results in only minor impacts on the epidemiological association between @entity2207 and @entity1468 . Citation: Avanasi R, Shin HM, Vieira VM, Savitz DA, Bartell SM. 2016. Impact of exposure uncertainty on the association between @entity2206 and @entity1468 in the C8 Health Project population. Environ Health Perspect 124:126-132;   http://dx.doi.org/10.1289/ehp.1409044.
