XXXX , an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae).

@entity4444 @entity1819 @entity28964 @entity30153 @entity1066 @entity3352 @entity35 @entity200 @entity1068 @entity2275
In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of @entity1819 induced by @entity1068 . The @entity1066 index (ULI) was significantly reduced by oral administration of the essential oil of B. dracunculifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The analysis of the chemical composition of the essential oil from B. dracunculifolia by GC showed that this was composed mainly of mono- and @entity200 and the majority compound was @entity28964 . Therefore, antiulcerogenic activity of @entity28964 (50, 250 and 500 mg/kg) was investigated using @entity1068 -, @entity3352 - and stress-induced @entity1066 models in @entity35 . In the stress-induced @entity1066 model, a significant reduction of the ULI in animals treated with @entity28964 (50, 250 and 500 mg/kg) and @entity4444 (100 mg/kg) was observed, compared to the control group (p < 0.05). The percentage of inhibition of @entity1066 was 41.22, 51.31, 56.57 and 53.50% in groups treated with 50, 250, 500 mg/kg of @entity28964 and 100 mg/kg of @entity4444 (positive control), respectively. Regarding @entity1068 - and @entity3352 -induced @entity1066 models, it was observed that the treatment with @entity28964 (250 and 500 mg/ kg) significantly reduced the ULI in comparison with the control group (p < 0.05). The dose of 50 mg/kg reduced the parameters analyzed but this was not statistically significant. In the @entity1068 -induced model percentage of inhibition of @entity1066 was 34.20, 52.63, 87.63 and 50.87% in groups treated with 50, 250, 500 mg/kg of @entity28964 and 30 mg/kg of @entity30153 (positive control), respectively. In @entity3352 - @entity1066 the percentage of inhibition of @entity1066 was 34.69, 40.80, 51.02 and 46.93% in groups treated with 50, 250, 500 mg/kg of @entity28964 and 100 mg/ kg of @entity4444 (positive control), respectively. The results of this study show that @entity28964 displays antiulcer activity, as it significantly inhibited the formation of @entity1066 induced in different animal models. However, further pharmacological and toxicological investigations, to delineate the mechanism(s) of action and the toxic effects, are required to allow the use of @entity28964 for the treatment of @entity2275 .
