The value of testosterone deprivation in stage D1 XXXX .

@entity1 @entity263 @entity342 @entity3 @entity204
The question of whether hormonal manipulation is effective in the treatment of stage D1 @entity263 has yet to be determined conclusively. To study this question a retrospective review was conducted of 68 @entity1 with stage D1 disease. Of the @entity1 22 underwent immediate orchiectomy, 24 delayed orchiectomy and 11 exogenous antiandrogen treatment (8 immediate and 3 delayed treatment), and 11 had no @entity342 deprivation. The @entity1 were placed into 2 groups consisting of those receiving immediate hormonal deprivation (30) and those having treatment at the time of bone @entity3 or who are as yet untreated (38). The minimum followup was 60 months. The median interval to progression to bone @entity3 was 43 months in the delayed treatment group compared to 100 months in the immediate hormonal deprivation group. This difference was statistically significant (p equals 0.0087). Likewise, the median period from diagnosis to @entity204 was 90 months in the delayed treatment group and 150 months in the immediate treatment group. This difference was not significant (p equals 0.1110). Thus, orchiectomy or adequate @entity342 deprivation from our data significantly prolongs the interval to bone @entity3 in @entity1 with @entity263 limited to the pelvic lymph nodes. The apparent increased length of survival of the immediate treatment group lacks statistical confirmation.
