Induction of XXXX in LSH hamsters.

@entity32 @entity3001 @entity625 @entity4 @entity2069 @entity603 @entity450
In studies of experimental @entity3001 , a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed @entity625 after injection of @entity2069 in the hind paws. When nonirradiated hamsters were injected in the hind paws with @entity2069 , acute transient @entity603 was present. A diffuse neutrophilic infiltrate involved the synovia and periarticular structures. The @entity32 was associated with @entity4 , @entity450 , and granulation tissue. Numerous spirochetes were seen in the synovial and subsynovial tissues. The histopathologic changes were enhanced in irradiated hamsters. The onset and duration of the induced @entity4 were dependent on the dose of radiation and the inoculum of spirochetes. Inoculation of irradiated hamsters with Formalin-killed spirochetes or medium in which @entity2069 had grown for 7 days failed to induce @entity4 . This animal model should prove useful for studies of the immune response to @entity2069 and the pathogenesis of @entity625 .
