Biochemical recurrence-free and XXXX -specific survival after radical prostatectomy at a single institution.

@entity1 @entity263 @entity5 @entity3121 @entity342 @entity1486
PURPOSE: To analyze the biochemical recurrence-free and @entity5 -specific survival after radical prostatectomy in a consecutive series of @entity1 with @entity263 . MATERIALS AND METHODS: We retrospectively reviewed data for 1,822 @entity1 who underwent radical prostatectomy with pelvic lymph node dissection at our institution between 1990 and 2009. After excluding 498 @entity1 who were treated with neoadjuvant @entity342 deprivation therapy or who were followed up for  <=6 months, we included 1324 @entity1 (mean age, 64.4 years; mean @entity1486 [PSA] level, 12.3 ng/ml). We assessed @entity1 age at the time of surgery, preoperative PSA concentration, biopsy and pathologic Gleason scores, pathologic stage, surgical margin status, disease progression, and survival. RESULTS: The mean follow-up time was 40 months (range, 6-193 months). The 5- and 10-year biochemical recurrence-free survival rates were 73.2% and 66.2%, respectively, and the 10-year @entity5 -specific survival rate was 92.4%. The mean time from surgery to biochemical recurrence was 18 months. In the multivariate analysis, Gleason score (4+3 vs. 2-6, p=0.004; 8-10 vs. 2-6, p<0.001), pathologic stage (pT3a vs. pT2, p=0.001; pT3b-4 vs. pT2, p<0.001; @entity3121 vs. pT2, p<0.001), and resection margin status (p<0.001) were statistically significant predictors of biochemical recurrence, with only pathologic stage (pT3b-4 vs. pT2, p=0.006; @entity3121 vs. pT2, p=0.010) being a statistically significant predictor of @entity5 -specific survival. CONCLUSIONS: Radical prostatectomy resulted in favorable @entity5 control in more than 70% of @entity1 after 5 years and a low (<10%) @entity5 -specific mortality rate after 10 years. The factors predictive of biochemical recurrence were Gleason score, pathologic stage, and resection margin status.
