Humoral immunity in XXXX pregnancy: interrelationships with maternal/neonatal complications and maternal metabolic control.

@entity1 @entity14380 @entity6 @entity465 @entity291
The presence of islet cell antibodies (ICA), @entity14380 ( @entity465 ), other organ-specific autoantibodies, insulin antibodies and two different types of immune complexes (AgAb) in @entity6 pregnant @entity1 treated with insulin during pregnancy was investigated and compared with maternal metabolic control and with the course and outcome of pregnancy. One hundred and eighteen pregnant @entity6 @entity1 were grouped according to type of @entity6 : 56 were insulin-dependent @entity6 @entity1 who had been previously treated with insulin (Group 1); 23 were non-insulin-dependent @entity6 @entity1 who had previously received diet or oral treatment (Group 2); 39 had gestational @entity6 (Group 3). 94 @entity1 were subjected to regular check-ups during pregnancy and blood samples were taken during the last month of pregnancy (phase A); some were treated with standard preparations of insulin, the remainder with purified insulins. 24 @entity1 were treated with purified insulins (a @entity291 and porcine mixture) on entering the study and blood samples were taken at regular intervals during pregnancy (phase B). ICA were detected in 12% of the @entity1 in Group 1 and in 5% of those in Group 3. There was no significant variation in the titre during the gestational period. ICA were not detected in the @entity1 in Group 2. No @entity465 were found in any of the @entity1 . The positivity of the other organ-specific autoantibodies was similar to that the normal control group. Insulin antibodies were found in concentrations of 67%, 73% and 25% in Groups 1,2 and 3 respectively during the last month of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
