Subthalamotomy improves @entity5212 -induced XXXX in monkeys.

@entity5212 @entity304 @entity4790 @entity910 @entity191 @entity4176 @entity2608
Hyperactivity of the subthalamic nucleus (STN) is major characteristic of @entity304 secondary to substantia nigra lesions. Interruption of the STN-internal pallidum (GPi) pathway is a new stereotactic target for @entity191 . We have studied the antiparkinsonian efficacy of STN lesions in @entity5212 -treated monkeys. Four @entity2608 were made @entity191 by @entity5212 (i.v. 0.15 +/- 1 mg/kg) administration over 3 months. Unilateral subthalamotomy ( @entity4176 ) was performed by a standard stereotactic method. Severity was rated from 0 (normal) to V by fine manual motor tests. Three monkeys (severity state III/IV) showed marked improvement in spontaneous activity, facial expression and manual dexterity bilaterally but significantly greater in the limb contralateral to the lesion. Mild hemichorea was present in 2 and hemiballism in one. L-Dopa treatment (50 mg b.i.d.) enhanced the hemidyskinesias moderately. The therapeutic effect has persisted for over 8 months postsurgery. Monkey No.4 (severity stage V) showed @entity4790 in the lower limb contralateral to the lesion but no improvement and died a few days later. Subthalamotomy improves @entity304 in moderately severe @entity191 monkeys. @entity910 might be a persistent complication.
