Teratogenic potential of purified @entity211 and @entity48023 in subchronically exposed XXXX .

@entity211 @entity137 @entity48023 @entity853 @entity212 @entity4901 @entity35
Male and female Sprague-Dawley (Spartan) @entity35 were exposed to dietary levels of 0, 60, 200 or 600 ppm purified @entity211 ( @entity212 ) or @entity48023 (PCA) for 181 days, through mating and pregnancy. The daily intakes of @entity212 were 0, 4, 13 or 43 mg/kg body weight and of @entity4901 were 0, 4, 12 or 41 mg/kg body weight. Animals exposed to @entity212 generally consumed more food than control animals during pregnancy. Dams at the high-dose level of both compounds showed evidence of @entity137 , weighing less on day 0 of gestation and gaining less throughout pregnancy than did the controls. Dams exposed to the high dose of @entity212 gained less weight during pregnancy (exclusive of the gravid uterus) than control dams. At the 43 mg/kg/day dose level @entity212 was embryolethal. Foetuses at the lower dose levels of @entity212 exhibited dose-related decreases in body weights. A reduction in crown-rump length and an @entity853 were seen at 13 mg/kg/day in @entity212 animals only. An intake of 41 mg PCA/kg/day was associated with a decrease in the number of corpora lutea and in embryolethality. PCA exposure also resulted in reductions in foetal body weight and crown-rump lengths of males at 4 and 41 mg/kg/day. Female foetuses were unaffected.
