Potentiated reinstatement of XXXX -seeking behavior following @entity2254 infusion into the basolateral amygdala.

@entity2254 @entity935 @entity2072 @entity1154 @entity35
Reinstatement of extinguished drug-seeking behavior following chronic drug self-administration has been demonstrated in @entity35 in the presence of conditioned cues. This experimental model of cue-induced relapse can be used to assess the neural circuitry involved in relapse. We have previously shown that blockade of @entity935 D1 receptors in the basolateral amygdala (BLA) abolishes conditioned cue-induced reinstatement of @entity2072 -seeking behavior. The present study tested the hypothesis that @entity2254 -induced facilitation of @entity1154 neurotransmission in the BLA would potentiate conditioned cue-induced reinstatement of extinguished drug-seeking behavior. During daily self-administration sessions over 10 consecutive days, @entity35 pressed a lever to receive @entity2072 infusions (0.2 mg/0.05 ml) paired with a light+tone compound stimulus. Following self-administration, @entity35 underwent daily extinction sessions, during which no stimuli were presented. On the test days, @entity35 received intra-BLA @entity2254 (10 or 30 micro g/side) or vehicle infusions followed by extinction or conditioned cue-induced reinstatement testing. @entity2254 infusions did not alter extinction responding relative to vehicle infusions. During reinstatement testing, conditioned cue presentation significantly increased responding over extinction levels, and intra-BLA @entity2254 produced a dose-dependent increase in lever responding relative to vehicle infusions. These findings suggest that enhanced @entity1154 tone in the BLA potentiates the motivational effect and/or salience of @entity2072 -paired cues during reinstatement.
