Truncated tau deregulates synaptic markers in @entity35 model for human XXXX .

@entity13859 @entity73 @entity195 @entity35 @entity528
Synaptic failure and @entity528 are two major neuropathological substrates of @entity73 in @entity195 ( @entity195 ). Only a few studies have demonstrated a direct relationship between these two @entity195 . To investigate tau mediated synaptic injury we used @entity35 model of @entity13859 that develops extensive neurofibrillary pathology in the cortex. Using fractionation of cortical synapses, we identified an increase in endogenous @entity35 tau isoforms in presynaptic compartment, and their mis-sorting to the postsynaptic density (PSD). Truncated transgenic tau was distributed in both compartments exhibiting specific phospho-pattern that was characteristic for each synaptic compartment. In the presynaptic compartment, truncated tau was associated with impairment of dynamic stability of microtubules which could be responsible for reduction of synaptic vesicles. In the PSD, truncated tau lowered the levels of neurofilaments. Truncated tau also significantly decreased the synaptic levels of Ab40 but not Ab42. These data show that truncated tau differentially deregulates synaptic proteome in pre- and postsynaptic compartments. Importantly, we show that alteration of Ab can arise downstream of truncated tau pathology.
