Epidemiologic study of XXXX in Honduras, 1975-1983.

@entity1 @entity1527 @entity235 @entity234 @entity3911
Between 1975 and 1983, 53 @entity1 with parasitologically proven @entity234 ( @entity234 ) and 16 @entity1 with suspected @entity234 were diagnosed in Honduras. The @entity1 ' ages ranged from 3 months to 10 years, but 95% were younger than 3 years old. Since 1978, when 16 @entity1 were reported, the yearly incidence has declined, and in 1982 only 4 @entity1 were reported. We located and interviewed the families of 57 of the 69 @entity1 . At the onset of illness, all 57 @entity1 lived in rural areas, and 55 lived in southern Honduras. All the @entity1 who were discharged from the hospital alive were still living at the time of the interview. A case-control study, using age-matched neighbors as controls, showed that @entity1 were significantly more likely to have lived in poorly constructed, wood-stick houses. We used an indirect immunofluorescence test to analyze blood samples for @entity3911 antibodies from 218 family members of @entity1 , 170 family members of controls, and 156 @entity1 living on the island of El Tigre, where 4 of the 5 most recently diagnosed @entity1 lived. Although 15 specimens gave a positive reaction to L. donovani antigen, each gave a stronger reaction when tested against @entity1527 cruzi antigen, suggesting that the reactions to @entity3911 were false positives. A serosurvey of 279 @entity235 of cases and controls and from El Tigre showed that 24 had positive reactions to L. donovani antigen, but only 4 (1.4%) had higher titers to @entity3911 than to @entity1527 .(ABSTRACT TRUNCATED AT 250 WORDS)
