[Cellular immune function and its clinical implications in 45 @entity1 with XXXX ].

@entity1 @entity404 @entity1198 @entity1582 @entity22397 @entity4155 @entity880 @entity74 @entity6393 @entity405
OBJECTIVE: To investigate cellular immune function and its clinical significance in @entity1 with @entity1582 ( @entity1582 ). METHODS: 45 @entity1582 @entity1 were divided into three groups:newly diagnosed (n=18), stable stage (n=17) and relapsed/refractory (n=10). The frequencies of T cell subtypes, natural killer (NK) cells, dendritic cells (DC), helper T cells (including @entity1198 and Th2), regulatory T cells(Treg) and Th17 cells in peripheral blood were detected by flow cytometry. Serum concentrations of @entity6393 ( @entity6393 ), @entity880 dehydrogenase (LDH) and hemoglobin (Hb) were also detected, respectively. RESULTS: Compared with controls and stable stage group, the ratios of @entity404 +/ @entity405 +, DC1/ @entity22397 , and @entity1198 /Th2, the numbers of Treg and NK cells were significantly lower in newly diagnosed group. However, the ratio of @entity4155 /Treg was significantly higher in newly diagnosed group (P<0.05). Compared with stable stage group, the ratios of @entity404 +/ @entity405 +, DC1/ @entity22397 and @entity1198 /Th2 were significantly lower, and the ratio of @entity4155 /Treg was significantly higher in relapsed/refractory group (P<0.05). In higher ISS stages, the ratios of @entity404 +/ @entity405 + and @entity1198 /Th2 were significantly lower and the ratio of @entity4155 /Treg was significantly higher (P<0.05). There were negative correlations between the ratios of @entity404 +/ @entity405 +, DC1/ @entity22397 , @entity1198 /Th2 and the levels of @entity6393 and LDH, respectively (P<0.05). The ratio of @entity4155 /Treg was positively correlated with the levels of @entity6393 and LDH (P<0.05). They were no correlated with the level of Hb (P>0.05). CONCLUSION: The abnormal ratios of @entity404 +/ @entity405 +, DC1/ @entity22397 , @entity1198 /Th2 and @entity4155 /Treg were closely related with @entity74 stages, treatment outcomes, progression and prognosis in @entity1582 @entity1 .
