Surface functionalized mesoporous @entity3440 nanoparticles as an effective carrier for @entity1259 delivery to XXXX cells.

@entity137 @entity10849 @entity12279 @entity5 @entity1259 @entity8681 @entity3440 @entity694 @entity14872 @entity970 @entity968
UNASSIGNED: Recent studies with inorganic nanoparticles modified with functional groups have demonstrated improvement in drug delivery into @entity5 cells. In the present study, we prepared, characterized, and evaluated mesoporous @entity3440 nanoparticles (MSNs) as carriers for @entity1259 (EPI) in order to improve the antitumor efficacy of this drug. MSNs were prepared and functionalized with @entity14872 , @entity968 ( @entity970 ) and @entity12279 - @entity968 ( @entity8681 - @entity970 ) groups. Different nanoparticulate formulations were loaded with EPI. The in vitro @entity137 and the in vivo antitumor efficacy of MSNs containing EPI were evaluated versus free EPI. The EPI release from nanoparticles was shown to be pH-dependent. The size of MSNs functionalized with @entity10849 - @entity968 (MSN- @entity8681 - @entity970 ) was 123.8  4.8nm. This formulation showed the best antitumor effects at an EPI dose of 9mg/kg in C-26 @entity694 model. The biodistribution results proved that MSN- @entity8681 - @entity970 -EPI had a higher @entity5 accumulation compared to free EPI, 3h after drug administration. The results indicated that this formulation could be effective nanocarriers for anti- @entity5 therapies.
