Anticholinergic drugs and health-related quality of life in older adults with XXXX .

@entity303 @entity1 @entity1032
Objectives: To examine the association between the use of anticholinergic drugs and the health-related quality of life (HRQoL) among community-dwelling older adults with @entity303 . Methods: This was a retrospective, longitudinal, cohort study of older  adults aged 65 years and above diagnosed with @entity303 using Medical Expenditure Panel Survey data. Anticholinergic drug exposure was measured using the Anticholinergic Drug Scale. The HRQoL measures of interest were Physical Component Score (PCS) and @entity1032 ( @entity1032 ). Two separate unweighted multiple linear regression analyses were performed to determine the association of anticholinergic drugs with PCS and @entity1032 , while adjusting for other factors and baseline HRQoL measures. Results: The study included 112 @entity1 with @entity303 ; 15.18% of whom used anticholinergic drugs. The majority of the @entity1 were between the ages of 65 and 79 years (53%), @entity1 (57%), and  had poor or low family income (65%). After controlling for other factors and baseline HRQoL, anticholinergic drug use was associated with 7.48 unit reductions in PCS (P  <0.01), whereas no association was found between anticholinergic drug use and @entity1032 . Baseline HRQoL measures were found to be significant in both models. Conclusion: Anticholinergic drugs  are associated with reduced PCS of HRQoL in older adults with @entity303 . The study findings suggest the need for carefully monitoring the health status of elderly @entity1 when prescribing anticholinergic agents in this vulnerable population.
