Evaluation of a novel XXXX -preserved wound covering gel on dermal wound healing.

@entity1 @entity1496 @entity19 @entity25107 @entity4 @entity12468 @entity4280 @entity4279
OBJECTIVE: Daily wound assessment, including dressing changes and the removal of old ointments causes discomfort for the @entity1 . We therefore developed a new thermoreversible and transparent gel formulation that allows for filling wounds of different shapes and depths. The aim of the study was to investigate the effect of a wound covering gel on wound healing and the skin's microcirculation. MATERIALS AND METHODS: Investigations were carried out in a standardized and reproducible wound model (hairless @entity19 SKH1/hr, n = 30). Three groups were studied by intravital fluorescence microscopy: treatment with @entity25107 -preserved wound covering gel, a formulation containing 3% @entity4280 ( @entity12468 )- @entity1496 , and physiological saline for control. Microcirculatory standard parameters were analysed. RESULTS: The non-perfused area vanished within 14 days due to angiogenesis. The venular diameter, @entity4 formation and functional capillary density showed no significant differences between the three groups. CONCLUSION: The use of the newly developed wound covering gel has no toxic effects on microcirculation and angiogenesis and reveals no significant differences in the overall assessment of microcirculation compared to the control group and the well-established @entity4279 . The transparent antibacterial wound covering gel allows for direct wound assessment. Due to its thermoreversible gel formulation it enables good wound contact and easy handling.
