Chemical adrenalectomy reduces @entity131 induced by XXXX .

@entity1 @entity131 @entity410 @entity4235 @entity35 @entity63 @entity4176 @entity519 @entity1251 @entity230
Glucocorticoids (GCs), the adrenal steroids secreted during stress, have numerous catabolic effects which include damage to neurons of the hippocampus, a principal neural target site for the @entity230 . In the @entity35 , the extent of GC exposure over the lifespan is a major determinant of the rate of hippocampal neuron death during aging. GCs also modulate the severity of @entity131 in the @entity35 following insults such as @entity410 or @entity519 - @entity63 . As evidence, exogenous GCs exacerbate, while adrenalectomy attenuates @entity131 after these insults. Thus, it is possible that diminution of endogenous GC secretion might protect the @entity1 hippocampus after similar neurological insults; adrenalectomy under such circumstances is obviously not a viable clinical option. We demonstrate the protective effects of transient chemical adrenalectomy with the GC synthesis inhibitor, @entity4235 . @entity35 were microinfused with the excitotoxin @entity4176 in order to induce @entity410 ; this insult caused a significant GC stress-response. Attenuation of that response with @entity4235 reduced the @entity1251 @entity131 produced by @entity4176 . @entity4235 did not change the intensity of @entity410 , but rather, apparently, changed the capacity of neurons to withstand the @entity410 . Thus, @entity4235 , which is used safely and efficaciously in other clinical contexts, might prove protective of the brain following @entity410 in the @entity1 .
