Role of apoptosis in modulation of the growth of XXXX colorectal tubular and villous adenomas.

@entity1 @entity5493 @entity5 @entity652 @entity204
To estimate the effect of cell proliferation and deletion on the growth of the @entity1 @entity652 and eight @entity5493 were examined. Tubular @entity652 were categorized into three grades of cellular atypia: mild, moderate, and severe. @entity5493 were given a single grade. Morphological characteristics of apoptosis (nuclear condensation and budding) were used to quantify an apoptotic index, AI (percentage of apoptotic cells in viable adenomatous cells). The apoptotic cells were found mainly among the basal site of the adenomatous tubules. The AIs of tubular @entity652 with mild, moderate, and severe grades of atypia were 3.5, 5.7 and 8.8 per cent, respectively. The AI of @entity5493 was 1.8 per cent, which was significantly lower than that of tubular @entity652 . The mitotic indices, MIs (percentage of mitotic cells in viable adenomatous cells) of tubular @entity652 were 0.41 per cent (mild), 0.58 per cent (moderate), and 0.83 per cent (severe), and for @entity5493 the MI was 0.38 per cent. There was a close positive relationship between the AI and @entity652 , which paralleled the grade of atypia. These results indicate that both cell proliferation and @entity204 were more frequent in @entity652 with severe atypia than in @entity652 with mild atypia. Moreover, the significantly lower AI of @entity5493 , known to develop into large @entity5 when compared with tubular @entity652 , suggests that reduced apoptoses may lead to a shift in tissue kinetics towards expansive growth.
