Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in @entity1 XXXX .

@entity1 @entity5 @entity2918 @entity1426 @entity1721 @entity189 @entity418 @entity2247
Cyclo-oxygenase (COX) is a key enzyme in the conversion of @entity1426 to @entity2918 . @entity2247 expression has been found in many @entity5 . This study analyzed the correlation between @entity2247 expression and angiogenesis or apoptosis in @entity1 @entity418 . The study examined the expression of @entity2247 in six @entity418 cell lines and in 100 @entity1721 , comparing intratumoral microvessel density (IMVD) and apoptotic index (AI) by immunohistochemistry and TUNEL methods. @entity2247 was variably expressed in all the cell lines examined. @entity2247 immunoreactivity was observed mainly in the cytoplasm of @entity189 cells. Significantly higher mean IMVD and lower AI were noted in the 51 strong @entity2247 expressing cases than in the 49 weak cases. IMVD and AI were negatively correlated. @entity2247 expression was higher in the @entity5 with lymphatic invasion than in the others. These data indicate that @entity2247 expression is associated with increased intratumoral microvessels and suppression of @entity5 cell apoptosis. Thus @entity2247 might play an important role in the angiogenesis and regulation of apoptosis in @entity1721 .
