Prognostic factors of XXXX --experience of the German Multicentre Study SGCRC. German Study Group @entity189 .

@entity1 @entity41 @entity5 @entity189 @entity188 @entity3121 @entity477
A reliable evaluation of results of multimodal treatment requires the knowledge of the course of disease in @entity1 treated by surgery alone and of the relevant prognostic factors. The data of a prospective multicentre observation study (Study Group @entity189 , SGCRC) were analyzed by uni- and multivariate methods for the endpoints locoregional recurrence and observed overall survival. 1121 @entity1 with @entity188 are included. In 1056 (94.2%) @entity1 the @entity5 was resected, 34 @entity1 (3.0%) received postoperative adjuvant therapy, 61 @entity1 (5.4%) preoperative and 25 (2.2%) pre- and postoperative radiation. The observed 5-year survival rate for R0 (no @entity41 ) was 55% (95% confidence interval 52-58%), for R1 and R2 only 7% (3-11%). Following R0 resection the 5-year survival rates varied according to pT (74-24%) and pN (68-33%). The 5-year survival was 74% (68-80%) for stage I, 62% (56-68%) for stage II, 40% (35-45%) for stage III and 9% (0-21%) for stage IV. Stage III is prognostically inhomogeneous: @entity3121 : 5-year survival 47% (39-55%), @entity477 , 3: 34% (27-41%) (p < 0.01). The rate of locoregional recurrence is influenced by @entity5 related factors (stage and @entity5 site) and treatment related factors. Local spillage of @entity5 cells, the treating institution and the individual surgeon are independent factors influencing locoregional recurrence. Between locoregional recurrence and observed 5-year survival exists a highly significant correlation. The most important @entity5 related prognostic factors following surgical treatment are @entity41 status (R classification) and anatomic extent as described by pTNM and stage grouping UICC). The treating institution as well as the individual surgeon are further independent "prognostic factors" which determine the frequency of locoregional recurrence and thus survival. In analysis of treatment results the institution and the surgeon should be considered, in studies on adjuvant treatment a stratification according to department and surgeon is needed.
