Effect of Antrodia camphorata on Inflammatory Arterial XXXX -Mediated Platelet Activation: The Pivotal Role of Protein Kinase C.

@entity32 @entity455 @entity82 @entity101 @entity10671 @entity1423 @entity2404 @entity2872 @entity1426 @entity7131 @entity584 @entity715 @entity10670 @entity1031 @entity460 @entity141 @entity731 @entity1028 @entity65
Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti- @entity32 , antimetastasis, and anticancer activities and plays a role in liver @entity82 , vasorelaxation, and immunomodulation. @entity32 leads to @entity455 and @entity65 , including @entity1028 , @entity101 , and @entity731 . Platelet activation plays a crucial role in intravascular @entity715 , which is involved in a wide variety of @entity65 . However, the effect of Antrodia camphorata on platelet activation remains unclear. We examined the effects of Antrodia camphorata on platelet activation. In the present study, Antrodia camphorata treatment (56-224    g/mL) inhibited @entity1423 induced by collagen, but not @entity2872 , an analogue of @entity2404 , thrombin, and @entity1426 . Antrodia camphorata inhibited collagen-induced @entity460 ( @entity141 ) mobilization and phosphorylation of @entity7131 ( @entity7131 ) and @entity584 . In addition, Antrodia camphorata significantly reduced the aggregation and phosphorylation of @entity7131 in @entity10670 ( @entity10671 ) activated platelets. In conclusion, Antrodia camphorata may inhibit platelet activation by inhibiting of @entity141 and @entity7131 cascade and the @entity584 pathway. Our study suggests that Antrodia camphorata may be a potential therapeutic agent for preventing or treating @entity1031 .
