Significance of endostreptosin antibody titers in poststreptococcal XXXX .

@entity1 @entity8 @entity883 @entity71681 @entity631
@entity71681 (ESS) is an immunologically well defined cytoplasmic antigen of group A and some group C streptococci. ESS is probably the pathogenetic @entity631 ( @entity631 ). Antibodies to ESS (ESS-Ab) were determined by microcomplement fixation in 1,102 @entity1 and by ELISA in 105 @entity1 . In 168 @entity1 with @entity631 (90 from the U.S.A. and 78 from Kuwait) the arithmetic mean titer was 45.2 (log10 1.40 +/- 0.606) and 50.2 (log10 1.51 +/- 0.394) respectively, both significantly elevated compared to 347 age matched @entity1 and adults from the U.S.A. whose arithmetic mean titer was 9.1 (log10 0.83 +/- 0.635) and 7.5 (log10 0.55 +/- 0.492) respectively and 139 @entity1 from Kuwait whose arithmetic mean titer was 15.7 (log10 0.92 +/- 0.495). In 51 @entity1 with @entity631 , the mean ELISA value was 67.5% higher than the values obtained from 54 normal age matched controls. @entity1 with @entity883 without renal involvement had only transiently and mildly elevated values. ESS-Abs in @entity1 with other types of @entity631 were in the range of normal. ESS-Ab titers do not parallel the titers of streptococcal exoenzymes. ESS-Ab titers are of importance for the differential diagnosis of @entity8 and of similar significance for the understanding of the pathogenetic mechanism of @entity631 . They are possibly of significance for therapy in the form of an active vaccine.
