XXXX and its impact on wound healing: an integrative review.

@entity1 @entity308 @entity167 @entity1131 @entity458 @entity2124
Wound healing is typically divided into 4 stages; disruption of any one of these stages can impair this process. This integrative review summarizes findings from key studies suggesting that @entity458 may exert a clinically relevant impact on wound healing. For example, stress has been shown to decrease levels of inflammatory mediators, prolonging the inflammatory stage of healing, and increasing overall healing time. @entity308 has also been linked with impeding wound healing. Hostility has also been correlated with decreased inflammatory mediators, conversely, effective communication has shown faster healing time. Compounding factors such as unhealthy behaviors are also linked to poor wound healing, such as decreased sleep, poor nutrition, reduced exercise, and increased @entity167 use. Clinical evidence suggests that @entity167 exposure can reduce angiogenesis. Limited sleep decreases @entity2124 secretion, resulting in decreased monocyte migration and activation of macrophages. @entity1131 can decrease capillary formation, collagen synthesis, and wound remodeling. Such evidence challenges clinicians to consider psychological factors when treating wound care @entity1 .
