Prospective Study of 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography for Detecting XXXX and Unknown Primary Sites.

@entity1 @entity788 @entity5 @entity4303 @entity14103 @entity13098
PURPOSE: @entity788 ( @entity788 ) are increasing in incidence, and accurate staging is important for selecting the appropriate treatment. @entity14103 imaging is a promising approach for detecting @entity788 and could help in selecting optimal therapeutic strategies. The aim of this study was to prospectively determine the clinical utility of @entity14103 positron emission tomography (PET)/computed tomography (CT) in detecting unknown primary and metastatic @entity788 . @entity1 AND METHODS: One hundred thirty-one @entity1 were enrolled in a prospective study of @entity1 undergoing @entity14103 PET/CT, @entity13098 single-photon emission computed tomography (SPECT)/CT and multiphasic CT scan, and/or magnetic resonance imaging in a blinded fashion with comprehensive biochemical testing. The primary outcome measure was the detection of lesions by each imaging study. RESULTS: @entity14103 PET/CT imaging detected 95.1% of lesions (95% CI, 92.4% to 96.8%) with an average maximum standardized uptake value of 65.4    47 (range, 6.9 to 244), anatomic imaging detected 45.3% of lesions (95% CI, 37.9% to 52.9%), and @entity13098 SPECT/CT detected 30.9% of lesions (95% CI, 25.0% to 37.5%), with a significant difference between imaging modalities (P < .001). In four of 14 @entity1 (28.6%), @entity14103 PET/CT found a previously unknown @entity5 , and detected primary GEPNET, lymph node, and distant metastases correctly in 72 of 113 lesions (63.7%) when compared with histopathology, with 22.1% and 38.9% detected by using @entity13098 SPECT/CT and anatomic imaging, respectively. On the basis of findings with @entity14103 PET/CT, 43 of 131 @entity1 (32.8%) had a change in management recommendation. In @entity1 with @entity4303 symptoms but negative biochemical testing, @entity14103 PET/CT detected lesions in 65.2% of @entity1 , 40% of which were detected neither by anatomic imaging nor by @entity13098 SPECT/CT. CONCLUSION: @entity14103 PET/CT imaging provides important information for accurate staging of @entity788 and selection of appropriate treatment interventions even in the absence of biochemical evidence of disease in symptomatic @entity1 .
