Two year prognosis of XXXX : the ACCESS experience.

@entity1 @entity370 @entity5406 @entity1353
A cohort of 215 @entity370 @entity1 from the ACCESS study underwent a clinical evaluation at study enrollment and two years later. Approximately 80% of subjects had an improved or stable FVC, FEV1, chest radiograph determined by Scadding stage, and @entity1353 scale. African-Americans had less improvement in FVC than Caucasians (p = 0.04). @entity1 with @entity5406 at presentation were more likely to have improvement in the chest radiograph at two-year follow-up (p = 0.007). @entity1 with a lower annual family income were more likely to worsen with respect to @entity1353 (p = 0.01) and more likely to have new organ involvement at two-year follow-up (p = 0.045). The development of new organ involvement over the two year follow-up period was more common in African-Americans compared to Caucasians (p = 0.002) and more likely in those with extrapulmonary involvement at study entry (p = 0.003). There was an excellent concordance between changes in FVC and FEV1 over the two-year period. However, changes in FVC alone were inadequate to describe the change in pulmonary status of the @entity1 , as changes in chest radiographic findings or the level of @entity1353 did often but not always move in the same direction as FVC. In conclusion, data from this heterogeneous United States @entity370 population indicate that @entity370 tends to improve or remain stable over two years in the majority of @entity1 . Several factors associated with improved or worse outcome over two years were identified.
