Serum @entity14539 : the missing link in the bone-vessel cross-talk in hemodialysis XXXX ?

@entity1 @entity454 @entity6 @entity14539 @entity730 @entity79 @entity729 @entity22
UNASSIGNED: We found for the first time that in @entity22 @entity1 , higher @entity14539 serum level was associated with severe @entity730 ( @entity730 ). In addition, cortical bone microarchitecture (density and thickness) assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at tibia was also independently associated with severe @entity730 . These results suggest that @entity14539 may be involved in the association of @entity79 with @entity729 in hemodialysis @entity1 . INTRODUCTION: Severe @entity730 are predictive of high cardiovascular mortality in @entity22 ( @entity22 ) @entity1 . In @entity1 with @entity454 , a high aortic @entity730 score was associated with lower bone turnover on bone biopsies. Thus, we hypothesized that @entity14539 , a Wnt pathway inhibitor mainly secreted by osteocytes and acting on osteoblasts to reduce bone formation, may be associated with @entity729 in @entity22 @entity1 . METHODS: Fifty-three @entity22 @entity1 , aged 53  years [35-63] (median [Q1-Q3]) were included. Serum was sampled before the @entity22 session to assay @entity14539 . Framingham score was computed and the @entity730 ( @entity730 ) score was assessed according to Kauppila method on lateral spine imaging using DEXA. Tibia bone status was evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). @entity1 were distributed into two groups according to their @entity730 score: @entity1 with mild or without @entity730 (score below 6) versus @entity1 with severe @entity730 (score of 6 and above). RESULTS: In multivariate analysis, after adjustment on age, dialysis duration and @entity6 , serum @entity14539 and cortical thickness were independently associated with severe @entity730 (odds ratio (OR)   =   1.43 for each 0.1  ng/mL increase [95  % confidence interval (CI) 1.10-1.83]; p   =   0.006 and 0.16 for 1 SD increase [0.03-0.73]; p   =   0.018, respectively). A second cardiovascular model adjusted on Framingham score and the above mentioned confounders showed similar results. CONCLUSIONS: Elevated @entity14539 serum level and poorer tibia cortical bone structure by HR-pQCT were positively and independently associated with higher odds of severe @entity730 in @entity22 patients. Serum @entity14539 may become a biomarker of @entity79 and vascular risk in @entity22 @entity1 .
