The Effect of Visual Feedback on Writing Size in XXXX .

@entity1 @entity227 @entity66 @entity73 @entity191
@entity191 ( @entity191 ) leads to impairment in multiple cognitive domains. Micrographia is a relatively early @entity191 , characterized by a global reduction in writing size and a decrement in size during writing. Here we aimed to investigate the effect of @entity227 on writing size in @entity1 with @entity191 . Twenty-five @entity1 with @entity191 without @entity73 and twenty-five age-matched controls had to write a standard sentence with and without @entity227 . We assessed the effect of @entity227 by measuring vertical word size (i), horizontal length of the sentence (ii), and the summed horizontal word length without interspacing (iii), comparing @entity1 with controls. In both @entity1 and controls, writing was significantly larger without @entity227 . This enlargement did not significantly differ between the groups. Smaller handwriting significantly correlated with @entity66 severity. Contrary to previous observations that @entity227 caused increased writing size in specifically @entity191 , we did not find differences between @entity1 and controls. Both groups wrote larger without @entity227 , which adds insight in general neuronal mechanisms underlying the balance between feed-forward and feedback in visuomotor control, mechanisms that also hold for grasping movements.
