A High-Salt Diet Differentially Modulates Mechanical Activity of Afferent and Efferent Collecting Lymphatics in XXXX Iliac Lymph Nodes.

@entity32 @entity64 @entity19 @entity4358 @entity1702 @entity3
BACKGROUND: The lymphatic system contributes to fluid homeostasis in various tissues. Recent evidence suggests that lymphangiogenesis induced by a @entity1702 ( @entity1702 ) is associated with blood pressure regulation. Lymph nodes, located along lymphatic pathways, are not only important secondary lymphoid tissues for cancer @entity3 , @entity32 , and immune responses, but are also important for fluid homeostasis. Afferent lymphatics collect lymph from the pre-nodal area and efferent lymphatics drain lymph out of the lymph nodes. However, the difference in mechanical activity between afferent and efferent lymphatics and the effect of a @entity1702 on these vessels have not been shown. METHODS AND RESULTS: Changes in mechanical activity of isolated afferent and efferent lymphatics in @entity1702 ( @entity1702 ) and 4-week @entity1702 @entity19 in response to increases in intraluminal pressures from 3 to 7   cm @entity4358 were measured using video-microscopy. The higher intramural pressure equivalently decreased pumping activity of afferent and efferent lymphatics in @entity1702 @entity19 . A @entity1702 suppressed the amplitude, ejection fraction, and @entity64 volume of afferent lymphatics, leading to marked reductions in pumping activity. In contrast, the pumping activities of efferent lymphatics were resistant to a @entity1702 and were preserved by enhancing the contraction frequency. CONCLUSIONS: A @entity1702 differentially modulated the mechanical activity of afferent and efferent collecting lymphatics in @entity19 iliac lymph nodes.
