Effect of intravenous omega-3 fatty acid infusion and hemodialysis on XXXX composition of free @entity1718 and phospholipids in @entity1 with end-stage renal disease.

@entity1 @entity5204 @entity844 @entity1474 @entity1718
BACKGROUND: @entity1 treated with hemodialysis (HD) have been reported to have decreased levels of   -3 @entity1474 ( @entity5204 ) in plasma and cells. The aim of this study was to investigate the effect of   -3 @entity5204 administered intravenously during HD, as well as the effect of HD treatment, on the @entity844 composition of plasma free @entity1718 (FFAs), plasma phospholipids, and platelet phospholipids. METHODS: Forty-four HD @entity1 were randomized to groups receiving either a single dose of a lipid emulsion containing 4.1 g of   -3 @entity5204 or placebo (saline) administered intravenously during HD. Blood was drawn immediately before (baseline) and after (4 hours) HD and before the next HD session (48 hours). @entity844 composition was measured using gas chromatography. RESULTS: The increase in   -3 FFAs was greater in the   -3 @entity5204 group compared with the placebo group, whereas the increase in total FFAs was similar between the 2 groups. In the   -3 @entity5204 group,   -3 @entity5204 in plasma phospholipids were higher after 48 hours than at baseline, and in platelet phospholipids,   -3 @entity5204 increased after 4 hours. In the placebo group, no changes were observed in   -3 @entity5204 in plasma and platelet phospholipids. CONCLUSIONS: Intravenous   -3 @entity5204 administered during HD caused a transient selective increase in   -3 FFA concentration. Furthermore,   -3 @entity5204 were rapidly incorporated into platelets, and the content of   -3 @entity5204 in plasma phospholipids increased after 48 hours.
