Activated charcoal and the absorption of XXXX in @entity35 .

@entity35 @entity20150 @entity68
The treatment of @entity68 poisoning has typically not included the administration of activated charcoal due to the lack of evidence supporting its efficacy. Several in vitro studies have demonstrated good adsorption of @entity68 in a variety of pH ranges that were comparable to those found with other drugs for which activated charcoal is clinically used. This study was designed to determine whether activated charcoal altered the gastrointestinal absorption of toxic doses of @entity68 as @entity20150 in an in vivo model. Seventy-five male @entity35 were randomly assigned into 5 groups: control given only distilled water; 100 mg elemental @entity68 and water; 1:1 charcoal to @entity68 ; 2:1 charcoal to @entity68 ; and 4:1 charcoal to @entity68 . All treatments were administered consecutively by gavage within 5 min. Physiological measurements and blood samples were taken at 0, 1, 4 and 8 h after treatment. There were no consistent differences in physiological measurements among the 5 groups. Mean serum @entity68 concentrations did not differ among Groups 2, 3, 4 and 5 at the 4 sampling times except at I h between Groups 4 and 5. The area under the curve for serum @entity68 concentrations did not differ among the treatment groups. Activated charcoal did not alter the extent of @entity68 absorption in the experimental model.
