Cytomegalovirus Genotype Distribution Among Congenitally and Postnatally Infected XXXX : Association of Particular Glycoprotein (g)B and gN Types With Symptomatic Disease.

@entity1 @entity20675 @entity17266 @entity16 @entity4538 @entity281 @entity16834
UNASSIGNED: Background.    @entity4538 is a leading cause of @entity281 , and there are limited data on prognosis markers in disease development. We aimed to study 3 virology targets (glycoprotein [g]B, gN, and UL144) to assess their correlation with @entity281 and various organ system involvement. Methods.    Forty-eight congenital cases and 58 postnatally infected @entity1 were included (2003-2014). Genotyping for the 3 targets and distribution among the cohorts were investigated, and the relationship between the gB, gN, and UL144 types with clinical manifestations in @entity281 was also studied. Results.    All of the genotypes were similarly represented among cohorts, and the most prevalent were the UL144B, @entity17266 , and @entity20675 genotypes. The @entity16834 genotype was associated with abnormal image findings by ultrasound and/or magnetic resonance in @entity281 (odds ratio [OR], 6.2; 95% confidence interval [CI], 1.1-34.3; P = .036); the @entity20675 genotype was associated with an elevated risk of developing @entity16 (OR, 7.0; 95% CI, 1.1-45.9; P = .043). Both @entity20675 and @entity16834 were independent factors for symptomatic @entity281 . Statistical analyses showed no association between any UL144 genotype and disease severity. Conclusions.    All of the genotypes can be involved in @entity281 , although the @entity16834 and @entity20675 genotypes might be associated with a more serious illness.
