[Correlation from Undiluted Vitreous Cytokines of Untreated Central XXXX with Spectral Domain Optical Coherence Tomography].

@entity1 @entity650 @entity227 @entity7 @entity1713 @entity2994 @entity3012 @entity2842 @entity2788 @entity1020
UNASSIGNED: Purpose: To correlate key inflammatory and pro-angiogenic cytokines from undiluted vitreous fluid of treatment-na  ve @entity1 with central @entity2994 (CRVO) with SD-OCT parameters. Methods: Thirty-five @entity1 (age 71.1 years, 24 phakic, 30 non-ischaemic) underwent intravitreal combination therapy, including single-site 23-gauge core vitrectomy. Twenty-eight samples from @entity1 with idiopathic, non-uveitis floaterectomy served as controls. Levels of @entity650 ( @entity650 ), @entity2842 ( @entity2842 ), and @entity7 ( @entity7 -A) were correlated with @entity227 (logMar), category of CRVO (ischaemic or non-ischaemic) and morphological parameters, such as @entity1020 ( @entity1020 ), thickness of @entity2788 (Tneuro), extent of @entity1713 ( @entity1713 ) and disintegrity of the IS/ @entity3012 and others. Results: Mean @entity650 was 64.7   pg/ml (SD      115.8), mean @entity2842 1015.7   pg/ml (     970.1), and mean @entity7 278.4   pg/ml (     512.8), which was significantly higher than the control values of @entity650 6.2        3.4   pg/ml (p   =   0.06), @entity2842 253.2        73.5   pg/ml (p   <   0.0000001) and @entity7 7.0        4.9   pg/ml (p   <   0.0006), respectively. All cytokines correlated highly with one another (correlation coefficient r   =   0.82 for @entity650 and @entity2842 ; r   =   0.68 for @entity650 and @entity7 ; r   =   0.64 for @entity2842 and @entity7 ). @entity650 correlated significantly with @entity1020 , TRT, @entity1713 , dIS/ @entity3012 , and dELM. @entity2842 correlated significantly with @entity1713 , dIS/ @entity3012 , and dELM. @entity7 did not correlate with changes in SD-OCT, while it had a trend to be higher in the ischaemic versus the non-ischaemic CRVO groups (p   =   0.09). Conclusions: The inflammatory cytokines were more often correlated with morphological changes assessed by SD-OCT, whereas @entity7 did not correlate with CRVO-associated changes in SD-OCT. @entity7 inhibition alone may not be sufficient to decrease the inflammatory response in CRVO therapy.
