Recurrence of XXXX after resection: patterns, treatments, and prognosis.

@entity1 @entity101 @entity96 @entity5 @entity160 @entity204
OBJECTIVE: We sought to determine the factors associated with survival after recurrence of @entity96 ( @entity96 ) after resection and the outcome of our prospectively applied treatment protocol. BACKGROUND: Very little is known about the prognosis of @entity96 that recurs after resection and the outcomes associated with treatments applied to recurrent @entity5 . METHODS: A total of 661 @entity96 @entity1 undergoing resection from January 1988 to January 2011 were reviewed to identify those with recurrence. Single recurrences with preserved liver function, and no portal @entity101 were treated with resection. @entity1 with multiple @entity5 or poor liver function and no major comorbidities were listed for transplantation. @entity1 with up to 3 @entity5 , each 4 cm or smaller, and not eligible for transplantation, received ablation. @entity1 not eligible for ablation received embolization. Other treatments such as systemic therapy and radiation were used in remaining @entity1 , but not in a systematic manner. RESULTS: Recurrent @entity96 developed in 356 (54%) @entity1 at a median time of 22 months from primary resection. Median survival from time of recurrence to @entity204 was 21 months. Variables independently associated with survival from recurrence included time from primary resection to recurrence, @entity160 more than 100 ng/mL at recurrence, @entity5 larger than 3 cm, BCLC stage at recurrence, and type of treatment rendered for the recurrence. All variables except treatment modality were significantly correlated with characteristics of the original @entity5 . CONCLUSIONS: Most of the variables associated with outcome after recurrence are linked to the @entity5 at initial presentation. Nevertheless, meaningful survival can be achieved with appropriate treatment of recurrent @entity5 .
