Impaired reproductive fitness in mothers of XXXX with juvenile autoimmune arthropathies.

@entity1 @entity410 @entity3465 @entity4932 @entity393
OBJECTIVE: To assess the reproductive fitness of mothers of @entity1 with @entity4932 ( @entity4932 ). METHODS: A mail survey assessing pregnancy outcome was carried out among mothers of @entity1 with @entity4932 ( @entity4932 mothers) treated at a tertiary paediatric rheumatology centre. The best friends of the @entity4932 mothers served as controls. Besides family history, sociodemographics and reproductive outcomes were measured, including the number of pregnancies, pregnancy complications and gestational age at the time of delivery. RESULTS: @entity4932 mothers (n = 227) and controls (n = 235) had similar sociodemographics and racial backgrounds. On average, @entity4932 mothers reported a greater number of conceptions than controls (3.5 vs 3.1; P = 0.01) but had significantly higher rates of pregnancy complications (25% vs 15%; P<0.001). Corrected for differences in the absolute number of pregnancies between groups, the chances of having a miscarriage [mean (s.d.), 0.12 (0.18) vs 0.09 (0.16); P = 0.02] or preterm delivery [0.08 (0.21) vs 0.04 (0.15); P<0.02] were significantly greater among @entity4932 mothers than controls. CONCLUSIONS: Mothers of @entity1 with @entity4932 have @entity410 . This phenomenon is unlikely to be the result of difficulty with conception but rather to be due to higher rates of @entity393 and @entity3465 .
