Trends in risk of recurrence after the first XXXX in adults younger than 55 years of age in Sweden.

@entity1 @entity64 @entity385
BACKGROUND: Previous studies on @entity64 recurrence in younger adults often contain small sample size which makes it difficult to study trends in @entity64 recurrence over a long period of time. AIMS: The aim of the present study was to investigate temporal trends in the risk of recurrence in younger @entity1 with a first @entity385 . METHODS: All @entity1 and @entity1 aged 18-54 years who had survived at least 28 days after a first @entity385 from 1987 to 2006 were identified in the Swedish Inpatient Register. The @entity1 were stratified into four 5-year periods according to their admission period and were followed up for a total of four years after the index event with regard to recurrent @entity385 . A Cox regression model was used to analyze the risk of recurrent @entity385 . RESULTS: Of the 17,149 @entity385 @entity1 who were identified, 2432 (14.2%) had a recurrent @entity385 event within four years. From the first to the last periods (1987-1991 versus 2002-2006), the four-year risk of recurrent @entity385 decreased by 55% (hazard ratio 0.45, 95% confidence interval 0.39-0.53) in @entity1 and 59% (hazard ratio 0.41, 95% confidence interval, 0.33-0.50) in @entity1 . The cumulative four-year risk was 11.8% (95% CI 10.55-13.25) in @entity1 and 9.8% (95% CI 8.40-11.46) in @entity1 during the last five-year period (2002-2006). CONCLUSIONS: The risk of recurrence among younger @entity385 @entity1 has decreased over the past 20 years. Despite these improvements, younger @entity1 are still at a high risk for recurrent @entity385 .
