Diagnosis and treatment of XXXX in liver transplant recipients in an endemic area.

@entity1 @entity9178 @entity3109 @entity272 @entity378
BACKGROUND: Treatment of @entity9178 ( @entity9178 ) with @entity3109 is recommended for transplant recipients with positive @entity272 ( @entity272 ). However, @entity272 could be an imperfect identifier of @entity9178 in this population. In addition, the risk of @entity3109 hepatotoxicity could be high in liver transplant recipients (LTR). A retrospective cohort study was performed to evaluate the diagnosis and treatment of @entity9178 in LTR. METHODS: Charts of all 547 @entity1 who received primary liver transplantation at a University Hospital in Spain between 1988 and 1998 were reviewed. RESULTS: @entity272 was performed in 373 @entity1 (71%) before transplantation. The result was positive in 89 (24%). The median follow-up after transplantation was 49 months. None of the @entity272 -positive @entity1 developed @entity378 ( @entity378 ), but 5 out of 284 @entity1 with negative @entity272 (1.76%) had active @entity378 (P=0.6). Twenty-three @entity1 received @entity3109 as treatment of @entity9178 according to the decision of the attending physician. None of these @entity1 developed @entity378 , but 4 of them (17%) presented @entity3109 hepatotoxicity. Among @entity1 who did not receive @entity3109 , 2 out of 21 (9.52%) with radiologic previous @entity378 developed active @entity378 versus 0.44% (2/452) among the remaining @entity1 (relative risk [RR], 27.8, 95% CI, 3.2-147). CONCLUSIONS: Treatment of @entity9178 with @entity3109 can not be recommended to LTR on the basis of a positive @entity272 because it is an imperfect identifier of @entity1 at risk of @entity378 . LTR with radiologic features of previous @entity378 are at higher risk of posttransplant active @entity378 . @entity3109 -related hepatotoxicity is more frequent among LTR than in the general population.
