Natural history and clinical outcome of XXXX diagnosed in the young adult.

@entity1 @entity5 @entity703
OBJECTIVES: To determine the natural history of @entity1 younger than 40 years (young @entity1 [YP] group) who are diagnosed with a @entity703 ( @entity703 ) and to compare the natural history of these @entity1 with the more typical older @entity1 (OP) with @entity703 . METHODS: We reviewed our database and identified 34 @entity1 (younger than 40 years old, median age 35) who underwent surgery for a sporadic @entity703 . The YP group outcomes were compared with 100 @entity1 between 41 and 85 years (median 65). We fit a Cox proportional hazards model to examine the relationship between age at presentation and recurrence risk. RESULTS: The median @entity5 size in the YP group was 3.8 cm (range 0.6 to 19) and in the OP group was 5.0 cm (range 0.9 to 22; P = 0.225). @entity5 were discovered incidentally in 51% and 56% of the YP and OP groups, respectively (P = 0.65). The frequency of partial nephrectomy did not differ between the two groups (35% YP and 30% OP, P = 0.55). The frequency of malignant histologic subtypes did not differ between the groups (P = 0.439). In the YP group, only larger @entity5 size (hazard ratio 1.23, 95% confidence interval 1.02 to 1.50, P = 0.034) was associated with a statistically significant increased risk of recurrence. Those in the YP group were not more or less likely to develop recurrence than those in the OP group (hazard ratio 0.79, 95% confidence interval 0.22 to 2.85, P = 0.72). The 5-year disease-free survival rate was 73% and 80% in the YP and OP groups, respectively (P = 0.23). The 5-year disease-specific survival rate was 85% and 84% in the YP and OP groups, respectively (P = 0.88). CONCLUSIONS: The findings of our study indicate that the natural history of RCTs is similar in both younger and older @entity1 . Young @entity1 were neither more nor less likely to develop recurrence compared with their older counterparts.
