Are persistently symptomatic XXXX associated with abnormal inflammatory profiles? A prospective study.

@entity1 @entity5752 @entity5788 @entity5737 @entity174 @entity4666 @entity3814 @entity1193 @entity12868 @entity687 @entity158 @entity371 @entity1118
STUDY DESIGN: A case-control study with prospectively collected samples for laboratory analysis in a series of @entity1 with @entity174 and a series of @entity1 without @entity174 who underwent fusion for @entity5752 . OBJECTIVE: Was an exploratory data analysis for candidate cytokine biomarkers present in the @entity174 milieu of @entity1 with persistent back @entity158 associated with @entity3814 . SUMMARY OF BACKGROUND DATA: Lumbar and thoracic compression @entity174 are common. Little is known about the presence of inflammatory mediators within fractured @entity5788 in the clinical setting. METHODS: Thirty @entity1 diagnosed with a single thoracic or lumbar compression @entity174 were treated with single level vertebroplasty. At the time of intervention, needle aspiration was carried out at the fractured level. A multiplexed bead assay was used to assess the presence of 27 different cytokines and inflammatory mediators. A control group consisted of needle aspiration samples of 30 lumbar @entity5788 from 13 @entity1 with @entity1118 but no @entity174 undergoing open instrumented fusion. RESULTS: Thirty @entity1 with 30 @entity174 consisted of 23 female and 7 male with a mean age of 77.5 years (SD 13.6; range 42 to 97) and a mean of 3.9 weeks of @entity158 (SD 3.1; range 1 to 12). The highest levels of inflammatory mediators were (in order): @entity1193 , PDGF, @entity5737 , @entity371 , @entity687 , and eotaxin. These mediators were present at concentrations>200 pg/mL. Compared with controls with @entity1118 , significant differences were present for 4 mediators: TNF, @entity12868 , @entity4666 , and IL-12. The panel of these 4 markers was 93.3% specific and 66.7% sensitive for @entity174 compared with the control group. CONCLUSIONS: Inflammatory mediators are present in needle aspirates of symptomatic @entity3814 . Some of these mediators show different levels than in @entity1 with @entity1118 but no @entity174 . LEVEL OF EVIDENCE: Diagnostic level of evidence II.
