XXXX therapy in @entity3124 due to seasonal and pandemic @entity683 .

@entity1 @entity3124 @entity1887 @entity228 @entity651 @entity683 @entity701 @entity1344 @entity1224 @entity288
BACKGROUND: Survey data suggest that Canadian intensivists administer @entity288 to @entity3124 @entity1 primarily in response to @entity1224 , perceived risk for @entity1887 and @entity1344 . OBJECTIVE: To describe variables independently associated with systemic @entity228 therapy during an @entity683 outbreak. METHODS: The present analysis was retrospective cohort study involving @entity3124 @entity1 with @entity683 in two Canadian cities. Hospital records were reviewed for @entity3124 @entity1 treated in the intensive care units (ICUs) of eight hospitals in Canada during the 2008 to 2009 and 2009 to 2010 @entity683 outbreaks. Abstracted data included demographic information, symptoms at disease onset, chronic comorbidities and baseline illness severity scores. Corticosteroid use data were extracted for every ICU day and expressed as @entity701 dose equivalent in mg. Multivariable regression models were constructed to identify variables independently associated with corticosteroid therapy in the ICU. RESULTS: The study cohort included 90 @entity1 with a mean (   SD) age of 55.0  17.3 years and Acute Physiology and Chronic Health Evaluation II score of 19.8  8.3. @entity1 in 2009 to 2010 were younger with more severe @entity651 but similar exposure to @entity288 . Overall, 54% of @entity1 received @entity288 at a mean daily dose of 343  330 mg of @entity701 for 8.5  4.8 days. Variables independently associated with corticosteroid therapy in the ICU were history of @entity1224 (OR 4.8 [95% CI 1.6 to 14.9]) and @entity1344 (OR 4.6 [95% CI 1.2 to 17.8]). CONCLUSION: Observational data revealed that @entity1344 and @entity1224 were associated with corticosteroid therapy in the critical care setting, similar to a recent survey of stated practice. Efforts to determine the effects of @entity288 in the ICU for these specific clinical situations are warranted.
