The role of a single XXXX measurement in the diagnosis of @entity177 and the prognosis of fetal viability.

@entity1 @entity3556 @entity1420 @entity7207 @entity177 @entity490
OBJECTIVE: To assess the role of a single maternal serum @entity1420 measurement in the immediate diagnosis of @entity177 and in the long term prognosis of fetal viability. DESIGN: A prospective comparative study of @entity1 presenting with @entity3556 and @entity490 in early pregnancy. The comparison group was defined retrospectively as @entity1 who presented with @entity490 without history of, or the subsequent occurrence of, @entity3556 and whose pregnancies continued to viability. The study groups were defined retrospectively as threatened-continuing, non-continuing (including blighted ovum, missed abortion, incomplete and complete abortion) and tubal pregnancy groups, according to the outcome of the pregnancies. SETTING: The emergency room at the gynaecology department of a teaching hospital. SUBJECTS: Four hundred and eighty-nine @entity1 presenting with singleton pregnancy, @entity3556 and/or @entity490 in the first 18 weeks of pregnancy. The comparison group comprised 131 @entity1 without @entity3556 whose pregnancies continued to viability. The study group comprised 358 @entity1 with 148 threatened-continuing pregnancies, 175 non-continuing and 35 @entity7207 . INTERVENTIONS: A 10 ml blood sample was taken and pelvic ultrasonography was performed at presentation. Otherwise, conventional management was used. MAIN OUTCOME MEASURES: @entity1420 levels were interpreted in accordance with the outcome of the pregnancy: comparison, threatened-continuing, non-continuing or tubal. Viability was defined as 28 weeks or more weeks of gestation. RESULTS: @entity1420 levels were significantly lower in the non-continuing and tubal pregnancy groups than in the comparison and threatened-continuing groups (P < 0.001 in all cases). A cut-off level at 45 nmol/1 was found to differentiate between the viable (comparison and threatened-continuing) pregnancies and the abnormal (non-continuing and tubal) pregnancies with 87.6% sensitivity and 87.5% specificity. CONCLUSIONS: A single serum @entity1420 measurement taken in early pregnancy is valuable in the immediate diagnosis of @entity177 and the long term prognosis of viability.
