Intrathecal chemotherapy for recurrent central nervous system XXXX .

@entity1 @entity706 @entity2592 @entity1500 @entity6537 @entity1499
PURPOSE: To report the use of intrathecal chemotherapy for two @entity1 with recurrent central nervous system (CNS) @entity6537 . DESIGN: Two interventional case reports. @entity1 : The clinical course of two @entity1 with documented recurrent CNS @entity6537 were retrospectively reviewed. INTERVENTION: Both @entity1 had previously undergone external beam radiation therapy to the orbit and brain, as well as systemic @entity1499 ( @entity1500 ) and intrathecal @entity2592 ( @entity2592 ), for primary CNS @entity6537 . Both @entity1 developed recurrent CNS @entity6537 and treatment involved intrathecal @entity1500 and @entity2592 delivered by means of an Ommaya reservoir. MAIN OUTCOME MEASURE: Survival and resolution of @entity6537 . RESULTS: Complete remission of the CNS @entity6537 was seen in both @entity1 . Both @entity1 maintain reading visual acuity in at least one eye. Both @entity1 remain disease free with @entity706 for greater than 5 years after initial diagnosis. CONCLUSIONS: Intrathecal chemotherapy for recurrent CNS @entity6537 seems to be effective in preserving vision and possibly increasing survival.
