Fibrogenic potentials of XXXX used as abrasive blasting substitutes.

@entity82 @entity7864 @entity137 @entity1711 @entity406 @entity1710 @entity720 @entity3440 @entity35 @entity6619
This study was designed to examine the fibrogenic potentials of four @entity7864 that are being used as substitutes for @entity3440 sand in abrasive blasting. Six groups of 100 male @entity35 , including four coal slag groups, a vehicle control, and a positive control for @entity82 (Minusil quartz), were used. Each dust treatment group was given a single 40-mg dose of test agent via intratracheal instillation. Interim sacrifices of 15 animals per group were performed at 2 d, 3 mo, and 6 mo posttreatment, with the terminal sacrifice conducted at 12 mo. @entity1710 and @entity1711 stained histologic sections were prepared from designated @entity406 -fixed tissues collected at each necropsy and examined microscopically. Pulmonary @entity6619 analyses were performed for each group at the 2-d and 12-mo sacrifices. Pulmonary function analyses were conducted for each group at the 3-, 6-, and 12-mo sacrifices. Lung @entity720 analyses were conducted for 15 animals in each group at the terminal sacrifice. The pulmonary fibrogenic potentials of the four coal slag groups were compared histologically with the Minusil and vehicle controls. A mild to moderate @entity82 , which was progressive with time, was noted in each of the coal slag groups. However, the coal slag-induced lung @entity82 was much less than that produced by Minusil. Differences in @entity82 among the individual @entity7864 were relatively minor and certainly not as striking as those between the slags and Minusil. Other data derived from this study, such as lung @entity720 content, pulmonary particulate burdens, pulmonary function, and animal body weights, provided further evidence of a reduced @entity137 for the @entity7864 compared to Minusil.
