Substaging of Lymph Node Status in Resected XXXX Has Strong Prognostic Correlations: Proposal for a Revised N Classification for TNM Staging.

@entity5 @entity1124 @entity3
BACKGROUND: The current @entity5 -node- @entity3 staging system for the pancreas does not incorporate the number of lymph nodes (LNs) with @entity3 . METHODS: Among 1649 pancreaticoduodenectomies, 227 stringently defined @entity1124 ( @entity1124 ) that had undergone a specific approach of LN harvesting were analyzed for the prognostic value of LN substaging protocols used for other gastrointestinal (GI) organs. RESULTS: The median number of LNs harvested was 18, and the median number of LNs with @entity3 was 3. Lymph node @entity3 was detected in 175 cases (77  %). The number of LNs involved correlated significantly with clinical outcome. When cases were substaged with the protocol already in use for the upper GI organs (N0: no @entity3 , N1: @entity3 to 1-2 LNs; N2: @entity3 to >= 3 LNs), the median overall survival times were 35, 21, and 18  months, and the respective 3-year survival rates were 46, 34, and 20  % (p  =  0.004). Analysis of the Surveillance, Epidemiology and End Results (SEER) database also confirmed the survival differences between these substages (median overall survival times of 23, 15, and 14  months and respective 3-year survival rates of 37, 22, and 18  %; p  <  0.0001). The substaging protocol for the lower GI organs (N0: no @entity3 ; N1: @entity3 to 1-3 LNs; N2: @entity3 to >= 4 LNs) also was significant, with median overall survival times of 35, 21, 18  months and respective 3-year survival rates of 46, 26, and 23  %; p  =  0.009). The association between higher N stage and shorter survival persisted with multivariate modeling for both protocols, although the prognostic value of the upper GI protocol appeared to be slightly stronger according to the Akaike Information Criterion method. CONCLUSION: In conclusion, with proper LN harvesting, the LN @entity3 rate in @entity1124 is very high (77  %). Substaging of LN @entity3 has significant prognostic value and needs to be considered in the N staging of @entity1124 . The protocol already in use for other upper GI tract organs, which currently also is proven significant for ampulla, would be preferable, although the lower GI tract protocol also is applicable.
