@entity1507 therapy in XXXX and @entity712 .

@entity1 @entity712 @entity63 @entity3362 @entity3361 @entity1507 @entity951 @entity10
@entity3362 are vasodilators of venous and arterial smooth muscle commonly prescribed both for @entity951 and @entity712 . Primarily venodilators, @entity3362 also affect the systemic circulation if administered in sufficient dosage. In the coronary circulation, the principal effect is on the large epicardial and collateral vessels. Blood is shunted toward the @entity63 subendocardium. In the majority of @entity1 with @entity951 , relief of symptoms by @entity3362 is primarily due to hemodynamic effects on preload and afterload, unless the @entity1 has @entity3361 . In @entity1 with @entity712 , @entity3362 decrease the resistance to the emptying of blood from the left ventricle as well as the filling pressure. @entity3362 are relatively well tolerated, except for an initial throbbing @entity10 which rapidly resolves as tolerance develops. @entity3362 are available in a multitude of forms including sublingual, oral, topical, transmucosal, intravenous, and spray preparations. Oral preparations undergo a first-pass effect in the liver, requiring larger doses. Other forms avoid this problem by direct transdermal absorption or the intravenous route. The latter has the advantage of rapid administration and ease of titration. The choice of @entity1507 depends upon the clinical situation.
