XXXX and @entity7072 downregulate telomere length in @entity73 at the late period after low-dose exposure.

@entity7072 @entity73 @entity149 @entity3207 @entity2073 @entity7071
UNASSIGNED: Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of @entity149 at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of @entity7071 , @entity7072 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 @entity2073 ) and 78 controls with vascular @entity73 . Detailed psychometric interviews were performed to obtain quantitative data on the stage of @entity73 . Results. Statistically significant telomere @entity3207 was demonstrated in groups of clean-up workers with radiation doses in 100-250 @entity2073 and 250-500 @entity2073 range (subsequently M    SD: 15.85    0.27; p< 0.02; 15.89    0,33; p< 0.02; control: 17.21    0,23). A decrease in RTL was in parallel to radiation dose increase and overexpression of negative telomere length regulators: @entity7072 genes and, to a lesser extent @entity7071 ; the opposite tendency was demonstrated for TERT GE. In exposed over 500 @entity2073 a significant TERT overexpression was combined with decreased @entity7071 and @entity7072 GE, and absence of significant RTL changes in comparison with clean-up workers exposed to lower doses indicating a certain independency between gene expression and telomere length changes and possible threshold effects at this dose range. Analysis of the group of exposed in comparison with non-exposed demonstrated a significant decrease (p = 0.03) both of the mean MMSE and RTL parameters suggesting influence of previous exposure. Conclusion. This study shows parallel changes in decline of cognitive function and telomere length and differences in @entity7072 , TERT and @entity7071 gene regulation at the late period after low dose and over 500 @entity2073 exposure.
