[ XXXX and @entity191 : biochemical and anatomo-clinical correlation].

@entity1 @entity303 @entity191 @entity1877 @entity2026 @entity56 @entity195
Intellectual deterioration may be observed in the course of @entity191 . Since it had been reported that central cholinergic systems degenerate in @entity195 and @entity195 , we measured the activity of @entity1877 acetyltransferase (C.A.T.) and the number of muscarinic receptors in various cortical regions of 12 control subjects and 20 @entity1 and compared these biochemical results with clinical and neuropathological data concerning the @entity1 . Thirteen of the @entity191 @entity1 showed signs of intellectual decline (moderate in 8, severe in 5) and neuropathological examination of the cortex revealed in 10 cases large number of @entity195 changes extending beyond the hippocampus. C.A.T. activity was decreased in the cerebral cortex in every @entity1 . The decrease was greater in intellectually deteriorated @entity1 and in the group with numerous senile changes in the cortex. The number of muscarinic receptors was increased in @entity1 that had been treated with anticholinergic drugs until they died, but also in those who had not received these drugs, suggesting and underlying denervation @entity56 . In the caudate nucleus, however, neither C.A.T. activity nor muscarinic receptor number was altered, indicating that the cortical cholinergic lesion was specific. Although in most cases @entity303 in @entity191 was of the Alzheimer type, the case of a @entity191 @entity1 in whom cortical C.A.T. activity was severely decreased, in spite of the absence of cortical histopathological evidence characteristic of @entity195 , suggests that a @entity191 different from the Alzheimer type also exists. In @entity191 as in @entity195 . activity in the cerebral cortex results from degeneration of the cholinergic neurones in the nucleus of Meynert which projects to the cortex. Although the severity of @entity2026 seems in relationship with the extent of degeneration, this could already begin before intellectual impairment is apparent.
