Effectiveness of nano- @entity692 toothpaste in reducing dentin XXXX : a double-blind randomized controlled trial.

@entity692 @entity1 @entity1388 @entity56
OBJECTIVE: The present double-blind randomized clinical trial aimed to compare the efficacy in reducing dentin @entity56 of a dentifrice formulation containing nano- @entity692 with a @entity1388 dentifrice and a placebo. METHOD AND MATERIALS: 105 subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: 1) nano- @entity692 15% toothpaste, @entity1388 -free; 2) @entity1388 toothpaste; 3) placebo. Groups 1, 2, and 3 were instructed to brush their teeth for 2 minutes twice a day with the provided toothpaste. The @entity1 's dentin @entity56 was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analog scale (VAS) was used. RESULTS: Significantly lower values of cold air sensitivity and tactile sensitivity (P<.001) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significantly (P<.001) lower values of sensitivity were reported for group 1 compared to groups 2 and 3, at 2 and 4 weeks respectively. The VAS scores were significantly lower (P<.001) in the test group at 2 and 4 weeks compared to baseline and to the control groups. CONCLUSION: The findings of the present study encourage the application of nano- @entity692 in @entity1388 -free toothpaste as an effective desensitizing agent providing quick relief from symptoms after 2 and 4 weeks.
