Compatibility of Astragalus and Salvia extract inhibits XXXX and ventricular remodeling by regulation of protein kinase D1 protein.

@entity296 @entity1711 @entity1710 @entity35 @entity583
AIMS: This study is to determine the effect of astragalus and salvia extract on the alteration of myocardium in a @entity35 model of @entity583 . METHODS: A total of 40 male @entity35 were randomly divided into the sham-operated group, the control group, the Astragalus group, the Salvia group, and the compatibility of Astragalus and Salvia and group. The cardiac functions were determined at 8 weeks after treatment. @entity1710 - @entity1711 staining was performed to observe the morphology and arrangement of cardiomyocytes. Masson's trichrome staining was performed to investigate the distribution of myocardial interstitial collagen. Immunohistochemical staining was performed to determine the expression ofprotein kinase D1 in myocardial tissues. RESULTS: In the sham-operated group, the Astragalus group, the Salvia group, and the compatibility of Astragalus and Salvia group, the left ventricular systolic pressure and the maximum rate of left ventricular pressure were significantly increased while the left ventricular end diastolic pressure were significantly decreased when compared with those in the control group (P < 0.05). Normal morphology and arrangement of cardiomyocytes were maintained in the compatibility of Astragalus and Salvia group. Contents of collagen fibers in myocardial tissues were decreased in the compatibility of Astragalus and Salvia group (P < 0.05). Expression levels of protein kinase D1 were significantly decreased in cardiomyocytes of the compatibility of Astragalus and Salvia group. CONCLUSIONS: Compatibility of Astragalus and Salvia extract may inhibit @entity296 and ventricular remodeling by regulation of protein kinase D1 protein in a @entity35 model of @entity583 .
