Long-Term Reproducibility of Macular Ganglion Cell Analysis in Clinically Stable @entity726 XXXX .

@entity1 @entity1538 @entity726 @entity2033 @entity389
PURPOSE: To investigate the long-term reproducibility of macular ganglion cell analysis in clinically stable @entity726 @entity1 using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred nine eyes of 109 clinically stable @entity1538 @entity1 with a localized retinal nerve fiber layer (RNFL) defect and a corresponding macular ganglion cell-inner plexiform layer (GCIPL) defect were included in this retrospective, longitudinal study. Clinical stability was defined as showing no change on serial structural (stereo-disc and RNFL photography) and functional (visual field progression analysis) assessments. Three serial SD-OCT ( @entity2033 ) peripapillary and macular scans taken at 6-month intervals were analyzed. Intraclass correlation coefficient (ICC), coefficient of variation (CV), test-retest standard deviation (TRTSD), and tolerance limit of area and angular width of @entity389 and GCIPL thickness measurements were assessed. RESULTS: The ICC of the GCIPL thickness parameters ranged from 0.966 to 0.992, and the CV from 2.0% to 5.5%. The TRTSD was the lowest for the average GCIPL thickness (1.45  m), the highest for the minimum GCIPL thickness (3.42  m), and varied from 1.54 to 2.16  m for the sectoral measurements. The ICC, CV, and TRTSD were 0.993, 3.9%, and 5.32   for angular width, and 0.930, 6.7%, and 0.27 mm2 for area of @entity389 . Measurement variances (TRTSD) for the GCIPL measurements showed no significant association with the glaucomatous severity. CONCLUSIONS: The macular GCIPL thickness and deviation maps showed excellent long-term intervisit reproducibility. Macular ganglion cell analysis can be considered as an effective means of monitoring glaucomatous progression in macula.
