The presence of @entity2940 / XXXX in @entity11511 correlates with the expression of cytotoxic molecules and is associated with worse response to treatment.

@entity1 @entity10730 @entity981 @entity2940 @entity10807 @entity13433 @entity4071 @entity2280 @entity11511 @entity405 @entity1116
Some cases of @entity11511 ( @entity981 ) express markers found in natural-killer (NK) cells, such as @entity2940 and @entity4071 . Out of 84 T-cell @entity981 cases diagnosed at our Institution, @entity2940 and/or @entity4071 was detected in 24 (28.5%), which we designated T/NK- @entity981 group. Clinical features, laboratory characteristics, survival and expression of cytotoxic molecules were compared in T/NK- @entity981 and @entity11511 @entity1 . Significant differences were observed regarding age (24.9 vs. 16.4 years in T/NK- @entity981 and @entity11511 , respectively, P = 0.006) and platelet counts (177 x 10(9)/l vs. 75 x 10(9)/l in T/NK- @entity981 and @entity11511 , respectively, P = 0.03). Immunophenotypic analysis demonstrated that @entity2280 , CD45RA and @entity1116 were more expressed in T/NK- @entity981 @entity1 , whereas @entity405 and @entity10730 were more expressed in @entity11511 @entity1 (P < 0.05). The mean overall survival (863 vs. 1869 d, P = 0.02) and disease-free survival (855 vs. 2095 d, P = 0.002) were shorter in @entity1 expressing @entity2940 / @entity4071 . However, multivariate analysis identified @entity2940 / @entity4071 as an independent prognostic factor only for DFS. Cytotoxic molecules were highly expressed in T/NK- @entity981 compared to @entity11511 . Perforin, @entity10807 and @entity13433 were detected in 12/17, 4/17 and 7/24 T/NK- @entity981 @entity1 and in 1/20, 0/20 and 1/20 @entity11511 respectively (P < 0.001, P = 0.036 and P = 0.054). Therefore, the presence of @entity2940 / @entity4071 was associated with distinct clinical features and expression of cytotoxic molecules in the blasts.
