Predictors of survival in XXXX of the head and neck.

@entity1 @entity5 @entity3 @entity204 @entity320 @entity1349
BACKGROUND: The head and neck is the most common site of @entity320 , a @entity5 with poor prognosis. In contrast to @entity320 , @entity320 of the head and neck (MMHN) is uncommon, with limited data regarding outcomes and prognostic factors drawn from small, single-institution case series. In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort. METHODS: MMHN cases (n = 815) diagnosed in the USA between 1973 and 2007 were analyzed in the Surveillance, Epidemiology, and End Results registry, and cause of @entity204 was individually determined in 778 (95.5%) cases. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to analyze prognostic variables. RESULTS: Disease-specific survival status was determined in 778 (95.5%) cases. The 5- and 10-year rates of @entity1349 ( @entity1349 ) were 25.2 and 12.2%; disease-specific survival (DSS), 32.4 and 19.3%. On multivariable analysis, anatomic primary site was an independent predictor of @entity1349 and DSS, with @entity5 in the nasal cavity and oral cavity associated with survival superior to @entity5 in the nasopharynx and paranasal sinuses. Age > 70 years, @entity5 size, nodal status, and distant @entity3 status were additional independent predictors of poorer survival. CONCLUSIONS: In this large cohort of @entity1 with MMHN, we have identified several novel factors robustly predictive of overall and @entity320 -specific survival.
