Association between Single Nucleotide Polymorphisms in XXXX and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis.

@entity71379 @entity23916 @entity20823 @entity32271 @entity71378
UNASSIGNED: The @entity20823 ( @entity20823 ) protein plays an important role in the repair of DNA double-strand breaks. The relationship between @entity20823 polymorphisms and the risk of radiation-induced @entity71378 on normal tissue remains inconclusive. Thus, we performed a meta-analysis to elucidate the association between @entity20823 polymorphisms and radiation-induced @entity71378 on normal tissue. All eligible studies up to December 2014 were identified through a search of the PubMed, Embase and Web of Science databases. Seventeen studies involving 656 cases and 2193 controls were ultimately included in this meta-analysis. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the association between @entity20823 polymorphisms and the risk of radiation-induced normal tissue @entity71378 . We found that the @entity20823 @entity32271 ( @entity23916 ) polymorphism was significantly associated with early @entity71378 induced by radiotherapy (OR = 1.99, 95%CI: 1.31-3.01, P = 0.001). A positive association lacking statistical significance with late @entity71378 was also identified (OR = 1.28, 95%CI: 0.97-1.68, P = 0.08). In addition, the @entity23916 polymorphism was significantly correlated with a higher risk of @entity71378 induced by head and neck area irradiation (OR = 2.41, 95%CI: 1.49-3.89, p = 0.0003) and breast irradiation (OR = 1.41, 95%CI: 1.02-1.95, p = 0.04), whereas the correlation was not significant for lung irradiation or pelvic irradiation. Furthermore, @entity20823 @entity71379 polymorphism may have a protective effect against late @entity71378 induced by radiotherapy (OR = 0.47, 95%CI: 0.26-0.86, P = 0.01). Well-designed large-scale clinical studies are required to further validate our results.
