Effects of XXXX on action potentials generation in @entity19 sinoauricular node strips.

@entity19 @entity4524 @entity974 @entity3303 @entity973
The physiological role of Ito has yet to be clarified. The goal of this study is to investigate the possible contribution of the transient outward current (Ito) on the generation of transmembrane action potentials (APs) and the sensitivity of @entity19 sinoauricular node (SAN) cells to a @entity973 ( @entity974 ) as Ito blocker. The electrophysiological identification of cells was performed in the sinoauricular node artery area (nstrips  =  38) of the subendocardial surface using microelectrode technique. In this study, for the first time, it was observed that dependence duration of action potential at the level of 20% repolarization (APD20) level under a @entity974 concentration in the pacemaker SAN and auricular cells corresponds to a curve predicted by Hill's equation. APD20 raised by 70% and spike duration of AP increased by 15-25%, when @entity974 concentration was increased from 0.1 to 5.0  mmol/L. Auricular cells were found to be more sensitive to @entity974 than true pacemaker cells. This was accompanied by a decrease in the upstroke velocity as compared to the control. Our data and previous findings in the literature lead us to hypothesize that the @entity974 -sensitive current participates in the repolarization formation of pacemaker and auricular type cells. Thus, study concerning the inhibitory effects of @entity3303 and @entity4524 on APD20 can explain the phenomenon of the decrease in upstroke velocity, which, for the first time, was observed after exposure to @entity974 . Duration of AP at the level of 20% repolarization (APD20) under a 4-AP concentration 0.5  mmol/L in the true pacemaker cells lengthen by 60-70% with a control.
