Comparative distribution patterns of @entity1413 and fibronectin in XXXX arteriosclerotic aorta.

@entity1 @entity75 @entity1294 @entity95 @entity1413 @entity4288
The distribution patterns of @entity1413 and fibronectin were studied in @entity75 of @entity1 aortas as well as in the regions devoid of any @entity75 of the same aortas. Frozen sections were analyzed for fibronectin and collagens by indirect immunofluorescence or immunoperoxidase analysis with specific antisera prepared in @entity95 against @entity1 plasma fibronectin and against @entity1 @entity1413 . Tissue samples were also stained for type I and III collagen distribution using Picro Sirius red according to the method described by Junqueira et al. (1979). In the regions devoid of any visible @entity75 , there is a co-distribution in the media of the aortic wall of @entity1413 , with a predominance of type I collagen. Type I collagen is also visible in the intima, as a continuous layer. This is attributed to an age-dependent change of the aorta ( @entity4288 ). Fibronectin can be demonstrated as a thin layer in the subendothelium and as a weak immunofluorescence over the media. In recent or evolutive @entity1294 , fibronectin and type III collagen appear to be strongly increased and superimposed. There is also an increase of type I collagen in the intimal region of the plaque. The co-distribution of type III collagen and fibronectin in the @entity1294 may suggest a tissue-repair-type of process, analogous to that which can be observed during wound healing. Our results suggest that in @entity75 , type III collagen and fibronectin are predominantly synthesized.(ABSTRACT TRUNCATED AT 250 WORDS)
