Evaluation of chromosome 8 and 11 aneuploidies in washings and biopsy materials of XXXX .

@entity1 @entity2007 @entity5 @entity1606 @entity150
We compared chromosome 8 and 11 aneuploidies on bladder biopsy @entity5 tissues and bladder washing @entity1606 ( @entity1606 ) and their relationship to @entity5 malignancy. Interphase fluorescence in situ hybridization (FISH) was applied to nuclei of washing material and biopsy samples of 17 @entity1 with @entity1606 . Incidence of cells having @entity2007 was clearly nonrandom from @entity1 to @entity1 . There was no significant difference in the incidence of aneuploid frequency for chromosomes 8 and 11 between biopsies of @entity150 and bladder washing samples (P > 0.05). For chromosome 8, incidence of disomic cells (having two signals) in @entity5 was significantly lower than in grade II @entity5 of both washing samples (P = 0.004) and biopsy materials (P = 0.005), indicating a high frequency of @entity2007 . The incidence of nuclei with four or more than four signals of chromosome 8 was significantly higher in @entity5 than in grade II @entity5 in washing samples (P = 0.031 and 0.003, respectively). Similarly, in biopsy material, the incidence of nuclei with more than four signals of chromosome 8 was significantly higher in @entity5 than in grade II @entity5 (P = 0.004). For chromosome 11, in both washing samples and biopsy materials, the incidence of disomic cells (having two signals) in @entity5 was significantly lower than that detected in grade II @entity5 (P = 0.031 and 0.014, respectively), indicating a high frequency of @entity2007 . In biopsy materials, the incidence of nuclei with three or four signals was significantly higher than that in grade II @entity5 (P = 0.014 and 0.012, respectively). These findings suggest that FISH analysis of bladder washing samples can be effectively detected as genetic changes of @entity150 . It might predict genetic progression of these @entity5 , which might be related to @entity5 stage, because higher stages of @entity5 showed a higher incidence of aneuploidies of chromosomes 8 and 11.
