Temporal Trends in Characteristics of Newly Diagnosed Nontraumatic XXXX of the Femoral Head From 1997 to 2011: A Hospital-Based Sentinel Monitoring System in Japan.

@entity1 @entity2530 @entity230 @entity39 @entity1252 @entity358 @entity395 @entity479
BACKGROUND: Nontraumatic @entity2530 of the femoral head (ONFH) is a @entity395 caused by @entity39 of unknown etiology. A few studies have demonstrated trends in the number of @entity1 with ONFH. However, there are no data on temporal trends in characteristics such as age, gender, and causative factors. To investigate this, we examined data from a multicenter hospital-based sentinel monitoring system in Japan. METHODS: A total of 3041 newly-diagnosed ONFH @entity1 from 34 participating hospitals who were reported to the system from 1997-2011 were analyzed. We examined age at diagnosis, potential causative factors, and underlying diseases for which @entity1 received systemic @entity479 administration. Their temporal trends were assessed according to date of diagnosis in 5-year intervals (1997-2001, 2002-2006, and 2007-2011). RESULTS: The gender ratio and distribution of potential causative factors did not change. Regarding underlying diseases requiring @entity479 administration, the proportion of @entity1 with @entity1252 decreased in males (10% to 6.4%) and in females (37% to 29%). Proportion of @entity1 with renal transplantation fell consistently across the study period in both males (3.8% to 1.2%) and females (3.2% to 0.8%). In contrast, the proportion of @entity1 receiving @entity230 for @entity358 (except asthma) significantly increased in both males (0.5% to 5.5%) and females (0.5% to 3.6%). CONCLUSIONS: This large descriptive study is the first to investigate temporal trends in the characteristics of ONFH, which provide useful information for future studies.
