Neurotoxicology of XXXX in the cat. Electrophysiological studies.

@entity51 @entity468 @entity1891 @entity16
@entity468 were given @entity1891 (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when @entity51 became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or other proprioceptors which responded to muscle stretch were encountered. Those primary endings of soleus muscle spindles which did respond were significantly reduced in dynamic but not length sensitivity. Length sensitivity of secondary endings was unchanged. Thresholds of secondary but not primary endings were elevated. The average conduction velocity of soleus motor axons was reduced 30% but no deficit was detected in motor nerve terminal function. Indirectly-elicited contractile tension of the soleus muscles of the neuropathic @entity468 was not significantly lower than that in untreated animals. Amplitudes of spinal monosynaptic reflexes were unaffected. These data indicate, that in the cat, @entity16 results partly from dysfunction in muscle spindles and peripheral nerves.
