Absence of neutralizing antibodies against XXXX among @entity1 in Kamphaeng @entity30637 , Thailand.

@entity1 @entity778 @entity30637 @entity281 @entity683
BACKGROUND: Influenza A/H5N1 actively circulated in Kamphaeng @entity30637 (KPP), Thailand from 2004 to 2006. A prospective longitudinal cohort study of @entity778 in 800 adults conducted during 2008-2010 in KPP suggested that subclinical or mild @entity281 had occurred among this adult cohort. However, this study was conducted after the peak of H5N1 activity in KPP. Coincidentally, banked serum samples were available from a prospective longitudinal cohort study of primary school @entity1 who had undergone active surveillance for febrile illnesses from 2004 to 2007 and lived in the same district of KPP as the adult cohort. OBJECTIVES: We sought to investigate whether subclinical or mild @entity281 had occurred among KPP residents during the peak of H5N1 activity from 2004 to 2006. STUDY DESIGN: H5N1 microneutralization (MN) assay was performed on banked serum samples from a prospective longitudinal cohort study of primary school @entity1 who had undergone active surveillance for febrile illnesses in KPP. Annual blood samples collected from 2004 to 2006 from 251 @entity1 were selected based on the criteria that they lived in villages with documented @entity281 . RESULT: No H5N1 neutralizing antibodies were detected in 753 annual blood samples from 251 @entity1 . CONCLUSION: During 2004-2006, very few subclinical or mild @entity281 occurred in KPP. Elevated H5N1 MN titers found in the adult cohort in 2008 were likely due to cross-reactivity from other @entity683 virus subtypes highlighting the complexities in interpreting @entity683 serological data.
