Gastric electrical stimulation with short pulses reduces vomiting but not @entity943 in XXXX .

@entity390 @entity235 @entity73 @entity391 @entity1951 @entity943
BACKGROUND _ AIMS: The aim of this study was to investigate the acute effects of 3 different methods of electrical stimulation in the prevention of @entity1951 -induced emetic response and @entity943 . METHODS: Seven female hound @entity235 chronically implanted with 4 pairs of electrodes on gastric serosa were used in a 5-session study. Saline and @entity1951 were infused in sessions 1 and 2, respectively. In the other 3 sessions with @entity1951 infusion, 3 different methods of electrical stimulation (short-pulse stimulation, long-pulse stimulation, and electroacupuncture) were applied. Gastric slow waves and @entity391 and behaviors suggestive of @entity390 were recorded in each session. In a separate study, additional experiments were performed in 5 vagotomized @entity235 to investigate vagally mediated mechanisms. RESULTS: @entity1951 induced @entity943 , uncoupling of slow waves, and @entity391 and behaviors suggestive of @entity390 (P < 0.02, analysis of variance). Long-pulse stimulation, but not short-pulse stimulation or electroacupuncture, was capable of preventing @entity1951 -induced @entity943 and gastric slow wave uncoupling. Short-pulse stimulation and electroacupuncture, but not long-pulse stimulation, prevented @entity391 and significantly reduced the symptom scores, which was not noted in the @entity235 with truncal vagotomy. CONCLUSIONS: Long-pulse stimulation normalizes @entity1951 -induced @entity73 with no improvement in @entity391 and behaviors suggestive of @entity390 . Short-pulse stimulation and electroacupuncture prevent @entity391 and behaviors suggestive of @entity390 induced by @entity1951 but have no effects on slow waves, and their effects are vagally mediated.
