Lipid levels in XXXX : systematic review and meta-analysis.

@entity1 @entity3610 @entity2299 @entity1674 @entity412 @entity165
OBJECTIVE: To quantify the magnitude and pattern of low-density lipoprotein (LDL) @entity165 and nonhigh-density lipoprotein (HDL) @entity165 levels in @entity1 with @entity3610 ( @entity3610 ) versus control @entity1 . DESIGN: Systematic review and meta-analysis of lipid levels in published cross-sectional studies worldwide where @entity3610 @entity1 and controls were examined and sampled. MAIN OUTCOME MEASURE(S): Differences in plasma lipids (including @entity1674 , HDL- @entity165 , LDL- @entity165 , and nonHDL- @entity165 ) in @entity3610 versus control subjects were calculated. Comparisons were made with and without body mass index (BMI) matching. RESULT(S): @entity412 levels were 26 mg/dL (95% confidence interval [CI] 17-35) higher and HDL- @entity165 concentrations 6 mg/dL (95% CI 4-9) lower in @entity1 with @entity3610 . Also, LDL- @entity165 and nonHDL- @entity165 concentrations were higher in @entity3610 : by 12 mg/dL (95% CI 10-16) and 19 mg/dL (95% CI 16-22), respectively. With BMI matching, LDL- @entity165 and nonHDL- @entity165 were still higher in @entity3610 : by 9 mg/dL (95% CI 6-12) and 16 mg/dL (95% CI 14-19), respectively. LDL- @entity165 and nonHDL- @entity165 differences were greater with National Institutes of Health criteria [15 mg/dL (95% CI 13-17) and 21 mg/dL (95% CI 16-25), respectively] versus Rotterdam criteria [8 mg/dL (95% CI 5-12) and 17 (95% CI 13-22), respectively]. CONCLUSION(S): @entity2299 is common in @entity3610 . Beyond known alterations in @entity1674 and HDL- @entity165 , @entity1 with @entity3610 have higher LDL- @entity165 and nonHDL- @entity165 , regardless of BMI. We recommend that all @entity1 with @entity3610 be screened for @entity2299 , including LDL- @entity165 and nonHDL- @entity165 determinations, for effective cardiovascular risk prevention.
