@entity10233 and @entity5161 exert modest beneficial actions on left ventricular diastolic function during @entity741 in XXXX .

@entity64 @entity296 @entity66 @entity63 @entity235 @entity10233 @entity432 @entity741 @entity3980 @entity5161
BACKGROUND: Volatile anesthetics exert cardioprotective effects during @entity741 . This investigation examined the regional systolic and diastolic mechanical responses to brief left anterior descending coronary artery ( @entity3980 ) occlusion in the central @entity63 zone and in remote normal myocardium in the conscious state and during @entity10233 and @entity5161 anesthesia. METHODS: Eighteen experiments were performed in nine @entity235 chronically instrumented for measurement of aortic and left ventricular pressure, cardiac output, @entity3980 coronary blood flow velocity, and @entity3980 and left circumflex coronary artery subendocardial segment length. Regional myocardial contractility was evaluated with the slope of the preload recruitable @entity64 work relationship determined from a series of left ventricular pressure-segment length diagrams in the @entity3980 and left circumflex coronary artery zones. Diastolic function was assessed with a time constant of isovolumic relaxation (tau), maximum segment lengthening velocity in @entity3980 and left circumflex coronary artery regions, and regional chamber stiffness constants derived using monoexponential and three-element exponential curve fitting in each zone. On separate experimental days, hemodynamics and indices of regional functional were obtained in the conscious state and during 1.1 and 1.6 minimum alveolar concentration end-tidal @entity10233 or @entity5161 before and during @entity432 . RESULTS: In conscious @entity235 , @entity432 abolished @entity64 work, increased chamber stiffness (monoexponential: 0.39 +/- 0.04 during control to 1.34 +/- 0.39 mm-1 during @entity432 ), and decreased the rate of early ventricular filling in the @entity63 zone. These changes were accompanied by increased contractility (slope: 103 +/- 8 during control to 112 +/- 7 mmHg during @entity432 ), rapid filling rate (maximum segment lengthening velocity: 46 +/- 5 during control to 55 +/- 7 mm.s-1 during @entity432 ), and chamber stiffness (monoexponential: 0.43 +/- 0.05 during control to 1.14 +/- 0.25 mm-1 during @entity432 ) in the normal region. Increases in tau were also observed in the conscious state during the period of @entity741 . @entity10233 and @entity5161 increased tau and decreased the slope and maximum segment lengthening velocity in a dose-related manner. Monoexponential and three-element element exponential curve fitting were unchanged by the volatile anesthetics in the absence of @entity63 . @entity296 and rapid filling rate were enhanced in the nonischemic region during @entity432 in the presence of @entity10233 and @entity5161 . In contrast to the findings in the conscious state, @entity63 -induced increases in tau and chamber stiffness in the @entity63 and normal zones were attenuated during anesthesia induced by @entity10233 and @entity5161 . CONCLUSIONS: The results indicate that increases in contractility of remote myocardium during brief regional @entity63 were preserved in the presence of @entity10233 and @entity5161 anesthesia. In addition, @entity10233 and @entity5161 blunted @entity63 -induced increases in tau and regional chamber stiffness in both the @entity63 and nonischemic zones. These results demonstrate that the volatile anesthetics may exert important beneficial actions on left ventricular mechanics in the presence of severe @entity66 and diastolic function during @entity63 .
