Effect of day care attendance on sensitization and @entity1097 wheezing differs by XXXX genotype in 2 population-based birth cohort studies.

@entity1 @entity566 @entity1097 @entity2938 @entity56
BACKGROUND: Variation in the @entity2938 gene ( @entity2938 /-16934) is associated with @entity56 among farmers' @entity1 but not among @entity1 not living on farms. OBJECTIVE: To test the hypothesis that the same genetic variant conferring protection in the farming environment is associated with reduced risk of developing @entity56 phenotypes among urban @entity1 attending day care in early life. METHODS: In 2 population-based birth cohorts (Manchester, United Kingdom, Manchester Asthma and @entity566 Study [MAAS]; Tucson, Ariz, Tucson @entity1 Immune Study [IIS]), @entity1 were recruited prenatally and followed prospectively (MAAS: 3, 5, 8 and 11 years; IIS: 1, 2, 3 and 5 years). We assessed @entity56 sensitization and @entity1097 wheezing at each follow-up. RESULTS: A total of 727 @entity1 participated in Manchester and 263 in Tucson. We found no significant associations between @entity2938 /-16934 and sensitization and @entity1097 wheeze in either cohort. However, a different pattern emerged when we explored the interaction between @entity2938 /-16934 and day care attendance on these outcomes. We found a significant interaction between day care and @entity2938 /-16934 on the development of sensitization in the longitudinal model in MAAS in that @entity1 carrying the T allele who attended day care were less likely to be sensitized than those who did not attend day care, whereas among AA homozygotes, the association tended to be in the opposite direction. In a longitudinal model in IIS, we found a significant interaction between day care attendance and @entity2938 /-16934 on the development @entity1097 wheezing. Significant interactions between @entity2938 /-16934 and day care were maintained when adjusting for socioeconomic status. CONCLUSION: The effect of day care on sensitization and @entity1097 wheezing may differ among @entity1 with different variants of the @entity2938 gene.
