Tumorigenesis: cell defense against XXXX ?

@entity5 @entity1457 @entity26 @entity1358 @entity519 @entity3
Microenvironmental elements can directly contribute to the induction and the maintenance of @entity5 . @entity26 is the main element in the cell microenvironment and @entity519 can affect the process of tumorigenesis. In response to @entity519 , cells change their pattern and characteristics. These changes suggest that it is not just adaptation, but some sort of cell defense against @entity519 . If @entity519 is corrected, then cell defense mechanisms are interrupted. An examination of the process of tumorigenesis helps to design better therapeutic strategies. A systematic review of the English literature was conducted by searching PubMed, Google Scholar, and ISI Web databases for studies on changes that defend and help cells to live in a @entity519 microenvironment. Cells respond to @entity519 by de-differentiation and an increase in @entity1457 proteins. Angiogenesis and deviation of inflammatory response in favor of @entity1358 and save the @entity26 -starved cells from death. Finally, anti-angiogenic therapies and more @entity519 enhance @entity3 , as @entity5 with low @entity26 concentration are more malignant than @entity5 with high @entity26 concentration. All these enable cells to migrate away from low @entity26 areas and seek a more conducive microenvironment. Therapies that make the microenvironment more @entity519 need to be revised. This has been done for anti-angiogenic therapies, previously considered to be anti- @entity5 approaches. Effective therapies may be correcting therapies which direct the @entity5 microenvironment towards natural physical/chemical condition. Correcting therapies either @entity5 cells to a normal form ( @entity5 cells) or help the immune system to eradicate @entity5 cells which can not be corrected.
