XXXX receptor activation can trigger electrical activity in human @entity11 cells.

@entity2227 @entity1024 @entity5 @entity11 @entity4176 @entity1023 @entity593 @entity140 @entity143 @entity141 @entity463 @entity3271
Cells from major types of @entity11 , i.e. @entity3271 and @entity463 , are able to generate action potentials upon a current injection similar to neurons (Patt et al. (1996) Neuroscience, 71, 601-611; Labrakakis et al. (1997b) J. Neuropath. Exp. Neurol., 56, 243-254. Here, we report that activation of ionotropic @entity2227 receptors by the selective agonist, @entity4176 , or by @entity2227 itself, depolarized the @entity5 cells in culture and living slices from @entity5 tissue, and can elicit volleys of action potentials, as recorded with the patch-clamp technique. Sixty-six percent of the @entity463 cells, 44% of the astocytoma and 86% of the @entity3271 cells responded to @entity2227 and the specific agonist of @entity140 / @entity4176 receptors, @entity4176 . The involvement of non- @entity143 ( @entity1024 ) receptors is further supported by the observation that both @entity4176 and @entity2227 currents were blocked by CNQX ( @entity1023 ). The receptor activation was accompanied by an increase in cytosolic @entity141 , as recorded with a @entity593 microfluorometric system. The @entity141 elevation was mediated by the activation of @entity141 channels due to membrane depolarization. The presence of voltage-gated @entity141 channels was confirmed by patch-clamp experiments. Taken together, these findings imply that the electrophysiological properties of @entity11 cells are more reminiscent of those of neurons than of glial cells.
