A Genetic Modifier of the Gut Microbiome Influences the Risk of XXXX and @entity2259 After Hematopoietic Stem Cell Transplantation.

@entity1 @entity11632 @entity2132 @entity2259
UNASSIGNED: The @entity1 gut microbiome is involved in vital biological functions, such as maintenance of immune homeostasis and modulation of intestinal development and enhanced metabolic capabilities. Disturbances of the intestinal microbiota have been associated with development and progression of inflammatory conditions, including @entity2132 ( @entity2132 ). The @entity11632 ( @entity11632 ) gene produces an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa. @entity11632 genotype has been shown to modify the gut microbiome. We hypothesized that @entity11632 genotype influences risk of @entity2132 and bacterial translocation after allogeneic hematopoietic stem cell transplantation (HSCT). @entity11632 genotype was determined in 150 consecutive @entity1 receiving allogeneic HSCT at our center. We abstracted clinical characteristics and outcomes from the transplantation database. Cumulative risk of any acute @entity2132 varied by @entity11632 genotype, with decreased risk in those with A/A genotype and increased risk in those with G/G genotype. In contrast, the cumulative incidence of @entity2259 was increased in those with A/A genotype. We conclude that the @entity11632 genotype influences risk of acute @entity2132 and @entity2259 after HSCT. We hypothesize that the mechanisms involve altered intestinal surface glycosylation and microbial composition but this requires additional study.
