Anti-Caries Effect of XXXX -Containing Formulations in vivo: A Systematic Review and Meta-Analysis.

@entity1 @entity1388 @entity369 @entity460
OBJECTIVE: To assess the anti-caries effect of @entity369 -containing formulations in vivo on caries lesions compared with @entity1388 or placebo. METHODS: Randomized or quasi-randomized @entity1 clinical trials wherein @entity369 was delivered by any method were considered. The MEDLINE, Web of Science, EMBASE, Cochrane Library, and CBM databases were searched to identify relevant articles published up to December 2014. Grey literature was also searched. Two authors performed data extraction independently and in duplicate using data collection forms. Each included study was assessed using the Cochrane risk of bias assessment tool. RESULTS: Of the 470 studies screened, 31 full articles were scrutinized and assessed for eligibility. Ten studies (n = 15,546 @entity1 ) were selected for final inclusion. The meta-analysis results (n = 7 studies) demonstrated a synergistic effect of @entity369 when used in conjunction with @entity1388 on early coronal and root caries compared with placebo or @entity1388 alone. No specific side effects related to @entity369 usage were identified. CONCLUSIONS: When used in combination with a @entity460 compound and @entity1388 , @entity369 potentially provides a superior anti-caries effect compared with matched formulations of @entity1388 alone. However, the level of evidence was downgraded because of risks of bias and potential publication bias. In the future, more high quality, non-industry-supported clinical studies in this research area are required before any definitive recommendations can be made.
