Prognostic significance of XXXX in @entity2828 is associated with @entity4910 expression.

@entity1 @entity2828 @entity588 @entity4093 @entity5 @entity39 @entity7762 @entity4910 @entity19767 @entity880 @entity3 @entity37916
BACKGROUND: At diagnosis, identification of reliable biological indicators of prognosis to allow stratification of @entity1 according to different risks is an important but still unresolved aspect in the treatment of @entity2828 ( @entity2828 ) @entity1 . This study aimed to explore the role of @entity7762 expression on prognosis of @entity2828 @entity1 . @entity1 AND METHODS: Specimens from 109 @entity1 with non-metastatic @entity2828 treated at the Rizzoli Institute with neoadjuvant chemotherapy (protocols ISG/SSGIII, @entity37916 , EW-2, EW-REN2, EW-REN3, EW-PILOT) and 17 @entity3 were studied. Sixty-eight @entity1 (62%) remained disease-free and 41 (38%) relapsed (median follow-up: 67 months, range 9-241 months). Expression of @entity7762 and of some of its targets ( @entity4910 , @entity588 , @entity4093 and @entity19767 ) was evaluated by qRT-PCR using TaqMan MicroRNA Assays and/or by immunohistochemistry on tissue microarrays from the same @entity1 . RESULTS: High expression of @entity7762 in localized @entity5 was significantly related to better event-free and overall survival (P = 0.004). Relevance of @entity7762 was confirmed by using different calibrators (normal mesenchymal stem cells and different normal tissues). By multivariate Cox regression analysis, low @entity7762 expression as well as nontotal @entity39 and high levels of @entity880 dehydrogenase were all confirmed as independent risk factors associated with poor outcome. Expression of @entity7762 was lower in @entity3 than in primary @entity5 . It inversely correlated with expression of @entity4910 and Ki-67. CONCLUSIONS: By demonstrating its relationship with clinical outcome, we propose evaluation of @entity7762 at diagnosis of @entity2828 @entity1 to allow early risk stratification. Validation of these results would nonetheless ultimately need a prospective assessment.
