Functioning XXXX with peripheral steroid cell proliferation: a report of twenty-four cases.

@entity43 @entity19967 @entity1 @entity1420 @entity5 @entity5000 @entity48 @entity134 @entity8940 @entity4303 @entity44
Twenty-four cases of an unusual type of @entity43 with functioning stroma in which bands of @entity134 -hormone-producing cells were located adjacent to the @entity5 are presented. The cells were of stromal lutein cell type in 14 cases, stromal Leydig cell type in two cases, and hilus cell type in eight cases. Of the @entity5 with peripheral lutein cells, 11 were monodermal @entity44 , including eight examples of @entity19967 , two strumal carcinoids, and one trabecular @entity4303 ; the other three @entity5 in this group were a @entity48 , a @entity5000 containing syncytiotrophoblast cells, and a metastatic @entity4303 . The @entity5 with peripheral stromal Leydig cells were a @entity19967 and a @entity4303 . Three of the @entity5 with peripheral hilus cells were @entity8940 , four were cysts of probable rete origin, and the eight was a @entity48 . The @entity1 ' ages ranged from 13-82 (average 58) years. Eighty percent of the @entity1 were postmenopausal; one was pregnant. Forty-two percent of the @entity1 had androgenic manifestations, 29% had evidence of hyperestrinism, and one (4%) had evidence of @entity1420 excess. In 29% of the cases there was no clinical evidence of hormonal imbalance. Those @entity5 with peripheral stromal Leydig cells or hilus cells were accompanied by androgenic manifestations in over one-half the cases, and those @entity5 with peripheral lutein cells had a slightly higher association with estrogenic rather than androgenic changes. @entity1 chorionic gonadotropin and its beta subunit were demonstrated by the immunoperoxidase technique in some neoplastic cells in 4 of the 17 cases in which it was performed. @entity43 with peripheral steroid-hormone-producing cells should be distinguished from the typical @entity43 with functioning stroma, which contains lutein cells scattered throughout its stroma.
