Effect of an alpha-adrenergic blocker, and ACE inhibitor and @entity918 on blood pressure and on renal function in type 2 @entity6 @entity1 with XXXX and @entity633 . A randomized cross-over study.

@entity1 @entity2175 @entity101 @entity6 @entity918 @entity11592 @entity21261 @entity633 @entity16427 @entity1011 @entity551
alpha-Adrenergic blockers are potential alternative antihypertensive agents for @entity6 @entity1 . Data on their relative efficacy and their effect on kidney function and @entity633 are very limited however. 76 @entity1 with @entity2175 , @entity101 (>/=140/90 mm Hg) and @entity633 (>/=30 mg/24 h) were randomized into three groups to receive @entity21261 (2.5-10 mg), @entity16427 (2-8 mg) or both. @entity1 of the first and second groups received a single agent for 4 months, the agents were then crossed for an additional period of 4 months followed by the addition of @entity918 (25 mg) for a third 4-month period. Blood pressure was monitored monthly, @entity1011 clearance and HbA1c were measured before and at the end of each treatment period. @entity1 of the third group received reduced doses of @entity21261 and @entity16427 for 4 months. @entity918 was then added for the subsequent 4 months. There was a significant decline in blood pressure values during the first period in all groups. @entity21261 : systolic blood pressure (SBP) 160 +/- 6 to 149 +/- 5 mm Hg; diastolic blood pressure (DBP): 101 +/- 3 to 94 +/- 3 mm Hg (p = 0.001). @entity633 declined from 350 +/- 105 to 205 +/- 96 mg/24 h (p = 0.001), @entity1011 clearance (CrCl) was unchanged. @entity16427 : SBP: 160 +/- 7 to 151 +/- 6 mm Hg; DBP: 97 +/- 4 to 90 +/- 4 mm Hg (p = 0.001). @entity633 373 +/- 121 to 322 +/- 107 mg/24 h (p = 0.065) and CrCl 87 +/- 7 to 91 +/- 6 ml/min. The combination of both agents at half doses was equipotent or superior to either drug alone. Cross-over of @entity21261 and @entity16427 reproduced the @entity551 effect and reversed the antialbuminuric effect. The addition of @entity918 resulted in a further decline of 6-14 mm Hg in SBP and 3-11 mm Hg in @entity11592 .
