Effects of Controlled Cortical Impact on the XXXX Brain Vasculome.

@entity1545 @entity32 @entity131 @entity19 @entity179 @entity130
UNASSIGNED: Perturbations in blood vessels play a critical role in the pathophysiology of @entity1545 and @entity179 . Here, we use a systematic genome-wide transcriptome screening approach to investigate the vasculome after @entity131 in @entity19 . @entity19 were subjected to controlled cortical impact and brains were extracted for analysis at 24   h post-injury. The core of the traumatic lesion was removed and then cortical microvesels were isolated from nondirectly damaged ipsilateral cortex. Compared to contralateral cortex and normal cortex from sham-operated @entity19 , we identified a wide spectrum of responses in the vasculome after @entity130 . Up-regulated pathways included those involved in regulation of @entity32 and extracellular matrix processes. Decreased pathways included those involved in regulation of metabolism, mitochondrial function, and transport systems. These findings suggest that microvascular perturbations can be widespread and not necessarily localized to core areas of direct injury per se and may further provide a broader gene network context for existing @entity32 , metabolism, and blood-brain barrier alterations after @entity131 . Further efforts are warranted to map the vasculome with higher spatial and temporal resolution from acute to delayed phase post- @entity130 . Investigating the widespread network responses in the vasculome may reveal potential mechanisms, therapeutic targets, and biomarkers for @entity131 .
