Effects of body XXXX reduction resulting from chemopreventive agent treatment on mammary gland morphology.

@entity7045 @entity1420 @entity5 @entity11069 @entity53 @entity1017 @entity7044 @entity35
Moderate reductions (< or = 15%) in body @entity1017 , similar to those observed after administration of some chemopreventive agents in chemically induced mammary @entity5 models, will result in @entity5 (up to 55%). The objective of this study was to determine whether changes in mammary gland differentiation, proliferation, apoptosis, and @entity53 and @entity1420 levels are affected by moderate reductions in body weight induced after chemopreventive agent treatment and dietary restriction. The body weights of female @entity35 were reduced by dietary restrictions to match those of @entity35 receiving @entity11069 ( @entity11069 ) at a dose known to inhibit @entity7044 ( @entity7045 )-induced mammary @entity5 . @entity11069 supplementation or dietary restrictions began 1 wk before MNU administration at 50 days of age. Mammary gland differentiation, proliferation, apoptosis, and serum levels of @entity53 and @entity1420 were measured at 50, 57, and 71 days of age. Casein expression, proliferating cellular nuclear antigen expression, and apoptosis were not significantly different from controls in the dietary-restricted group. Proliferating cellular nuclear antigen expression was significantly lower in @entity11069 -treated animals than in controls at 57 days of age. The diameter of the mammary gland ducts was smaller at 71 days of age in the treatment groups. A decrease in @entity53 levels for each group was observed at 50 days of age, but not at later time points. @entity1420 levels were reduced in the @entity11069 group, but not in the dietary-restricted group, during each time period. It would appear that the observed decrease in mammary @entity5 observed with moderate reductions in body @entity1017 might be due to multiple related factors different from those related to @entity11069 treatment.
