XXXX and the occurrence of falls in an older population.

@entity4512 @entity1 @entity1118 @entity158
CONTEXT: @entity1118 is a major contributor to disability in older adults; however, the potential role of @entity1118 as a risk factor for falls is poorly understood. OBJECTIVE: To determine whether chronic @entity4512 is associated with an increased occurrence of falls in a cohort of community-living older adults. DESIGN, SETTING, AND @entity1 : The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Boston Study is a population-based longitudinal study of falls involving 749 adults aged 70 years and older. @entity1 were enrolled from September 2005 through January 2008. MAIN OUTCOME MEASURE: @entity1 recorded falls on monthly calendar postcards mailed to the study center during an 18-month period. RESULTS: There were 1029 falls reported during the follow-up. A report of 2 or more locations of @entity4512 at baseline was associated with greater occurrence of falls. The age-adjusted rates of falls per @entity1 -year were 1.18 (95% confidence interval [CI], 1.13-1.23) for the 300 @entity1 with 2 or more sites of joint @entity158 , 0.90 (95% CI, 0.87-0.92) for the 181 @entity1 with single-site @entity158 , and 0.78 (95% CI, 0.74-0.81) for the 267 @entity1 with no joint @entity158 . Similarly, more severe or disabling @entity158 at baseline was associated with higher fall rates (P < .05). The association persisted after adjusting for multiple confounders and fall risk factors. The greatest risk for falls was observed in @entity1 who had 2 or more @entity158 sites (adjusted rate ratio [RR], 1.53; 95% CI, 1.17-1.99), and those in the highest tertiles of @entity158 severity (adjusted RR, 1.53; 95% CI, 1.12-2.08) and @entity158 interference with activities (adjusted RR, 1.53; 95%CI, 1.15-2.05), compared with their peers with no @entity158 or those in the lowest tertiles of @entity158 scores. CONCLUSIONS: @entity1118 measured according to number of locations, severity, or @entity158 interference with daily activities was associated with greater risk of falls in older adults.
