The Comparison of Infusion of Two Different Sedation Regimens with XXXX and @entity3652 Combination During Plastic and Reconstructive Surgery.

@entity1 @entity3652 @entity1875 @entity158 @entity282 @entity65
OBJECTIVE: Anesthetic agents are often combined to enhance their therapeutic effects while minimizing adverse events. The aim of this study was to evaluate the effects of two different sedation regimens of @entity3652 and @entity1875 combination via infusion on perioperative variables in @entity1 who underwent plastic and reconstructive surgery. METHODS: This randomized double-blind clinical trial was done on 80 @entity1 who were randomized to two groups; group 1 (n  =  40) received a 2:1 mixture of 9  mg/ml @entity1875 and 4.5  mg/ml @entity3652 , and group 2 (n  =  40) received a 4:1 mixture of 9  mg/ml @entity1875 and 2.25  mg/ml @entity3652 . After premedication and before local anesthetic injection, the infusion of mixtures was adjusted to attain the Ramsay sedation scores of 5 in both groups. We recorded induction time, sedation efficacy, cardiovascular and respiratory events, recovery time, and incidence of adverse events during and after the procedure. RESULTS: The mean of volume infusion of mixtures in the beginning of the procedure was higher in group 2 (3.2      1. 2  ml) than in group 1 (2.4      0.8  ml) (p  <  0.001). The induction time for sedation was 2.8      0.8  min and 2.6      0.4  min in group 1 and group 2, respectively (p  =  0. 92). The number of oversedated @entity1 was greater in group 2 compared to group 1 but not statistically significant (p  =  0. 80). The sedation efficacy was similar between the two groups. The hemodynamic changes during the procedure were greater in group 2 compared to group 1 (p  =  0. 001). The recovery time was not significantly different between the two groups (p  =  0.43). The mean @entity158 score in the recovery room was lower in group 1 than group 2 (1.2      0.8 vs 2.8      1.8, p  =  0. 01). Moreover, 4 (10  %) @entity1 in group 1 and 10 (25  %) @entity1 in group 2 needed opioid administration (p  =  0. 02). Other postoperative adverse events were similar between the two groups. CONCLUSION: We recommend the use of a 2:1 combination of @entity1875 - @entity3652 , because it reduced the rescue @entity1875 requirement and consequently produced lower @entity65 effects and also less @entity282 . LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
