XXXX downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells.

@entity1 @entity455 @entity75 @entity4538 @entity3820 @entity281 @entity731 @entity71509 @entity59827 @entity18514
Infection by @entity4538 ) is associated with the development of @entity455 and may cause severe @entity75 in infected fetuses. Platelet-derived growth factor receptors alpha and beta ( @entity18514 ) control important cellular processes associated with @entity731 and fetal development. In the present investigation, our goal was to determine whether infection by HCMV can influence the expression of @entity18514 in @entity1 smooth muscle cells (SMCs). In connection with HCMV infection in vitro the levels of @entity18514 at the cell surface and in the total cellular protein of SMCs were reduced in parallel with decreases in the levels of the corresponding mRNAs. These effects were dependent on immediate-early (IE) or early (E) HCMV gene products, since inhibition of late genes did not prevent HCMV from affecting the expression of @entity18514 . The downregulation of @entity3820 caused by HCMV was dose dependent. Furthermore, confocal microscopy revealed that the localization of @entity3820 was altered in HCMV-infected cells, in which this protein colocalized with proteins associated with endosomes ( @entity71509 ) and lysosomes ( @entity59827 ), indicating entrance into pathways for protein degradation. Altogether these observations indicate that an IE and/or E HCMV protein(s) downregulates the expression of @entity18514 in SMCs. This phenomenon may disrupt cellular processes of importance in connection with cellular differentiation, migration, and/or proliferation. These observations may explain why @entity281 with HCMV can cause fetal @entity75 .
