Surgical results of metastatic @entity1745 (MSCC) from @entity1149 ( XXXX ): analysis of functional outcome, survival time, and complication.

@entity1 @entity5 @entity1149 @entity2 @entity51 @entity1745
BACKGROUND CONTEXT: A number of studies have reported favorable surgical results for metastatic @entity5 from various solid @entity5 . However, there are few data available on metastatic @entity1745 (MSCC) from @entity2 despite its considerable frequency. PURPOSE: The study aims to present the functional outcomes, survival time, and complications after surgical treatment for MSCC from @entity1149 ( @entity1149 ). STUDY DESIGN/SETTING: This is a longitudinal observational study. @entity1 SAMPLE: The study includes 50 @entity1 who had @entity51 and underwent surgical treatment for MSCC from @entity1149 . OUTCOME MEASURES: The Eastern Cooperative Oncology Group performance status (ECOG-PS), ambulatory status, overall survival, factors associated with survival time, and perioperative complications were analyzed. METHODS: The postoperative changes of ECOG-PS and ambulatory status were assessed. The factors affecting postoperative ambulatory status were evaluated using logistic regression analysis. Survival time was calculated using the Kaplan-Meier method. To identify the prognostic factors, log-rank test and Cox hazards regression model were used for univariate and multivariate analyses, respectively. Major complications within postoperative 30 days and mortality rate were recorded. RESULTS: The study cohort consisted of 27 males and 23 females with a mean age of 58.0  11.3 years at the time of surgery. An ECOG-PS improvement by at least one grade was observed in 33 of 50 cases (66.0%). Among 39 @entity1 who were not ambulatory before surgery, 23 @entity1 (59.0%) regained ambulatory ability after surgery. @entity1 who were preoperatively ambulant and those who underwent surgery within 72 hours from @entity51 had an increased chance of postoperative ambulation. The median for overall survival after surgery was 5.2 months. Five prognostic factors were identified on univariate analysis: time from @entity51 , responsiveness to preoperative chemotherapy, postoperative chemotherapy, postoperative ECOG-PS, and postoperative ambulatory status. Multivariate analysis revealed that time to @entity51 (risk ratio [RR]: 2.28, p=.023), postoperative chemotherapy (RR: 6.58, p<.001), and postoperative ECOG-PS (RR: 2.73, p=.040) were independent prognostic factors of survival time. Major complications developed in 34.0% of @entity1 (17 of 50), and the 30-day mortality rate was 10.0% (5 of 50). CONCLUSIONS: Functional improvements were observed through surgical treatment even with relatively high complication rates for MSCC from @entity1149 . Earlier surgical treatment could act as an adjuvant therapy for prolonging survival by improving functional status.
