Intravenous Thrombolysis is Effective in Young Adults: Results from the Baden-Wuerttemberg XXXX Registry.

@entity1 @entity64 @entity5275 @entity385
BACKGROUND: The efficacy of @entity5275 ( @entity5275 ) is sufficiently proven in @entity385 @entity1 of middle and older age by means of randomized controlled trials and large observational studies. However, data in young @entity64 @entity1  <=50   years are still scarce. In this study, we aimed to evaluate the effectiveness and safety of @entity5275 in young adults aged 18-50   years. Data from a consecutive and prospective @entity64 registry was analyzed that covers a federal state with 10.8 million inhabitants in southwest Germany. METHODS: Our analysis comprises 51,735 @entity385 @entity1 aged 18-80   years and hospitalized from January 2008 to December 2012. Of these, 4,140 (8%) were aged 18-50   years and 7,529 (15%) underwent @entity5275 . Data on 8,439 @entity1 (16% of the study population) were missing for National Institutes of @entity64 severity score at admission and/or modified Rankin Scale (mRS) at discharge and were excluded from outcome analysis. In sensitivity analysis, @entity1 with incomplete data were also examined. Binary logistic regression models were used adjusted for @entity1 , hospital, and procedural parameters and stratified by age group (18-50 and 51-80   years, subgroup analyses 18-30, 31-40, and 41-50   years) to assess the relationship between @entity5275 and mRS at discharge. RESULTS: @entity5275 appears equally effective in young adults 18-50   years (adjusted odds ratio 1.40, 95% confidence interval 1.12-1.75; p   =   0.003), compared to @entity1 51-80   years of age (1.33, 1.23-1.43; p   <   0.001). Age-stratified analyses suggest an inverse relation of age and effectiveness, which appears to be highest in very young @entity1 18-30   years of age (2.78, 1.10-7.05; p   =   0.03). DISCUSSION: @entity385 etiology, vascular dynamics, and recovery in young @entity1 differ from those of middle and older age. The evidence from routine hospital care in Germany indicates that @entity5275 in young @entity64 @entity1 appears to be at least equally effective as in the elderly.
