XXXX with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases.

@entity1 @entity788 @entity82 @entity1689 @entity29 @entity74 @entity3527
To clarify clinicopathologic features of @entity1689 with lymphoplasmacytic infiltration, we carried out a study of 35 cases. There were two histologic groups, which we have designated lymphoplasmacytic sclerosing @entity788 and @entity1689 . Lymphoplasmacytic sclerosing @entity788 (22 cases) was a fibrosing process with diffuse lymphoplasmacytic infiltrates involving pancreatic lobules and ducts, adipose tissue, blood vessels, and common bile duct. Obliterative @entity3527 was found in every case except for one. The histologic features were similar to other @entity74 , and one @entity1 also had retroperitoneal @entity82 . Affected @entity1 tended to be elderly @entity1 . @entity1689 (13 cases) was characterized by inflammatory infiltrates (including neutrophils) that were denser in the lobules than in interlobular fibrotic areas. Neutrophils were also prominent in the ducts, and destruction of the duct epithelium was commonly seen. @entity1 ages were more broadly distributed than in lymphoplasmacytic sclerosing @entity788 . Two @entity1 had @entity29 . We conclude that @entity1689 with lymphoplasmacytic infiltration, sometimes called autoimmune @entity788 , consists of at least two different processes. One of these, lymphoplasmacytic sclerosing @entity788 , is a histologically unique lesion and could be a pancreatic manifestation of @entity74 .
