Factors Affecting Penetration of XXXX in Lower Extremity Ischemic Tissues.

@entity1 @entity6 @entity3657 @entity16 @entity2177
UNASSIGNED: The aims of this study were to evaluate factors influencing the distribution of @entity2177 in tissue of @entity1 suffering from varying degrees of @entity3657 ( @entity3657 ). Blood and tissue samples were collected from @entity1 undergoing debridement or amputation procedures and the amount of @entity2177 in them was determined using high-performance liquid chromatography. All @entity1 were administered a 200-mg dose of intravenous @entity2177 prior to the debridement or amputation procedure. Data, including @entity1 gender, age, type of @entity6 , presence of @entity16 , medications taken, and severity of @entity3657 were collected. These data were then analyzed to determine factors influencing the concentrations of @entity2177 in tissue of the lower limbs. The Kruskal-Wallis test, Spearman correlation, and chi-square test were used to relate covariates and fixed factors with the concentration of @entity2177 in tissue. Following bivariate analysis, a 3-predictor regression model was fitted to predict tissue concentrations of @entity2177 given information about these predictors. Blood and tissue samples were collected from 50 @entity1 having an average age of 68 years. Thirty-three @entity1 were males and 35 @entity1 suffered from type 2 @entity6 . The average number of medications that these @entity1 were taking was 10. The majority of @entity1 (n = 35) were suffering from severe @entity3657 . Tissue concentrations of @entity2177 were mainly related to plasma concentrations of @entity2177 , number of medications that the @entity1 were taking and severity of @entity3657 .
