Influence of vasoactive substances on early toxic XXXX in the @entity235 .

@entity2871 @entity3143 @entity235 @entity349 @entity1855 @entity3371 @entity2918 @entity810 @entity141 @entity3352 @entity16982
The influence of different vasoactive substances on the evolution of @entity3143 -induced @entity810 ( @entity810 ) was evaluated in the @entity235 . @entity3143 alone caused a progressive fall in both glomerular filtration (GFR) and renal blood flow (RBF) during the first 3 h of the @entity349 administration (delta after 3 h: -44% and -39%) and provoked a concomitant stimulation of the renin-angiotensin (RAS) and @entity2871 systems. The administration of the @entity2871 inhibitor @entity16982 (2 mg/kg i.v. every 2 h) adequately inhibited the activation of the @entity2871 system after @entity3143 , but could not prevent the fall in GFR and RBF. The continuous intrarenal administration of the @entity141 entry blocker @entity1855 (0.005 mg/kg per min) into the left kidney resulted in the prevention of the postmercurial fall in GFR and RBF at the perfusion site. This beneficial effect was immediately lost when the @entity1855 administration was stopped. Finally, the administration of the converting enzyme inhibitor @entity3371 (300 micrograms/kg every 2 h) resulted in an effective inhibition of the renin-angiotensin system, the prevention of the postmercurial fall in RBF, and the partial attenuation of the fall in GFR. This beneficial effect was immediately lost after the intravenous administration of @entity3352 (2 mg/kg). These results indicate that the fall in GFR after @entity3143 can be prevented by vasoactive agents such as @entity3371 and @entity1855 and point at least in part to a pathophysiological role of the renin-angiotensin system or of an alteration in the equilibrium between renin-angiotensin and @entity2918 . The @entity2871 system is seemingly of no major importance.
