THERAPY OF ENDOCRINE DISEASE: XXXX supplementation and body composition: results from a meta-analysis study.

@entity1 @entity251 @entity1619 @entity412 @entity209 @entity165
OBJECTIVE: The role of @entity251 (T) in regulating body composition is conflicting. Thus, our goal is to meta-analyse the effects of @entity1619 ( @entity1619 ) on body composition and metabolic outcomes. METHODS: All randomized controlled trials (RCTs) comparing the effect of @entity1619 on different endpoints were considered. RESULTS: Overall, 59 trials were included in the study enrolling 3029 and 2049 @entity1 in @entity1619 and control groups respectively. @entity1619 was associated with any significant modification in body weight, waist circumference and BMI. Conversely, @entity1619 was associated with a significant reduction in fat and with an increase in lean mass as well as with a reduction of fasting glycaemia and insulin resistance. The effect on fasting glycaemia was even higher in younger individuals and in those with @entity209 . When only RCTs enrolling hypogonadal (total T <12mol/l) subjects were considered, a reduction of total @entity165 as well as @entity412 (TGs) levels were also detected. Conversely, an improvement in HDL @entity165 levels as well as in both systolic and diastolic blood pressure was not observed. CONCLUSION: Our data suggest that @entity1619 is able to improve body composition and glycometabolic profile particularly in younger subjects and in those with metabolic disturbances. Specifically designed studies are urgently needed to confirm this point.
