Botulinum toxin type A as treatment of partially accommodative XXXX .

@entity1 @entity1736 @entity892 @entity5971
OBJECTIVE: To determine the effectiveness of a botulinum toxin type A injection in both medial rectus muscles in @entity1 with partially accommodative @entity5971 . Residual deviation and stability of strabismus were evaluated at 18 months follow up. METHOD: A prospective, analytical, quasi-experimental study was conducted on a cohort of 21 @entity1 who underwent total cycloplegic refraction and with a residual deviation of at least 14 DP. A botulinum toxin type A dose of 5 IU was injected into each medial rectus muscle for a residual deviation greater than 18 DP, with a dose of 2.5 IU being used for a deviation between 14 and 18 DP. Multivariate logistic regression analyses were performed to relate residual deviation to variables recorded as potential predictors. RESULTS: A total of 21 @entity1 were included, 33.3% (n=7) males and 66.6% (n=14) females. Mean visual acuity was -.28  .25 logMAR for right eye (range 0 to -1) and -.42  .31 logMAR for left eye (range 0 to -1.3). Mean angle of residual deviation before application of botulinum toxin was 40.95  8.6DP without spectacles correction, and 22.3  7.99 DP with full cycloplegic refraction. Adverse effects were @entity1736 in 14.2% (n=3), @entity892 23.8% (n=5), and vertical deviation in 33% (n=7). One @entity1 had a poor outcome, therefore required surgical treatment. At one year follow up, 85.71% of @entity1 showed good results with @entity5971 of 12 DP or less, dropping to 71.43% at 18 months of follow up. CONCLUSION: Botulinum toxin type A is an effective long-term treatment with a good response in 71.43% of @entity1 . No predictors of good response were demonstrated.
