Effect of the blood supply to the normal noninfarcted myocardium on the incidence and severity of early post-occlusion XXXX in @entity235 .

@entity296 @entity235 @entity1188 @entity432 @entity2224 @entity3980 @entity453 @entity850 @entity943
This work was initiated by the discrepancy existing between the traditional experimental @entity1188 model with occlusion of one single major coronary artery in the otherwise healthy myocardium and the clinical situation in which two or more major coronary arteries are stenosed at the same time. A model mimicking this latter clinical situation was elaborated as follows: In anaesthetized, open-chest @entity235 the haemodynamic, electrophysiological and blood flow changes due to 5 min occlusion of the left anterior descending coronary artery ( @entity3980 ) were studied in the absence and presence of a critical constriction of the left circumflex coronary artery (LCX). Control @entity432 resulted in enhanced ST-segment elevation and inhomogeneity of electrical activation, depressed left ventricular contractility (LVdP/dt) and local myocardial contractility, as well as in a decline of @entity296 ( @entity296 ) in the ischaemic area supplied by @entity3980 . These changes were accompanied by no or slight extrasystolic activity. In the presence of critical @entity850 of LCX, occlusion of the @entity3980 aggravated @entity296 , i.e. ST-segment elevation and diminution of @entity296 were more marked, mainly in the subepicardium of the ischaemic area. The incidence and severity of @entity943 significantly increased. Even @entity2224 occurred in one third of the animals, both during @entity432 and after its release. Thus, acute @entity432 in the presence of a stenosed LCX produced a more severe @entity296 associated with more severe @entity943 than occlusion of @entity3980 alone. This model is more relevant to the clinical situation in which multivessel @entity453 is common.
