Glomerular morphology in @entity1985 XXXX addicts.

@entity4521 @entity1 @entity8 @entity644 @entity1987 @entity6 @entity70770 @entity3450 @entity177 @entity1463 @entity3630 @entity8424 @entity1985 @entity1445
Renal biopsies of 23 @entity4521 addicts who presented with the @entity1985 were examined by light and electron microscopy. The majority of @entity1 (14) showed @entity8 on light microscopy, four @entity1 showed "minimal change", and two were classified as "focal @entity1463 ." In one case focal mesangial proliferation was the outstanding feature; one @entity1 had @entity6 ; and one had @entity3630 and dysproteinemia. Visceral epithelial swelling and proliferation were present in 14 @entity1 on light on light microscopy. Electron microscopy showed distinct podocyte changes consisting of loss of foot processes, vacuolization, and cytoplasmic degeneration; focal separation of podocytes from basement membranes was found in 11 of 18 cases. In some instances a few electron-dense deposits were present in the mesangium. @entity8 was not encountered, although it occurs in 30 to 40% of unselected adult @entity1985 individuals. Of 15 @entity1 followed for 2 months to 5 years, one died of @entity4521 @entity1445 , eight went into @entity177 , two improved, and four continued to have @entity644 . It is concluded that @entity1985 of @entity4521 addicts is most often associated with @entity8 and occasionally with @entity1987 or focal @entity1463 . Conceivably these three conditions represent different phases of one disease process, although different reactions to @entity4521 or its various vehicles and contaminants cannot be excluded. The morphologic resemblance to experimental @entity8424 and @entity70770 -induced @entity3450 suggests a possible toxic origin.
