Effect of fluid shear stress on portal vein remodeling in a XXXX model of @entity101 .

@entity101 @entity1575 @entity40656 @entity1711 @entity1184 @entity12468 @entity1710 @entity842 @entity1827 @entity35
Aims. To explore the effects and mechanisms of fluid shear stress on portal vein remodeling in a @entity35 model of @entity101 . Methods. Subcutaneous injections of @entity40656 were given to establish a @entity35 model of @entity1575 and @entity101 . Biomechanical technology was adopted to determine the dynamic changes of haemodynamic indices and fluid shear stress. @entity842 (NO), synthase (NOS), and @entity1827 ( @entity1827 ) of the portal vein blood were measured. Changes in geometric structure and ultrastructure of the portal vein were observed using optical and electron microscopy. Results. After the CC14 injections, @entity35 haemodynamics were notably altered. From week 4 onwards, @entity12468 , PVF, and PVR gradually and significantly increased (P < 0.05 versus baseline). The fluid shear stress declined from week 4 onwards (P < 0.01 versus control group). NO, NOS, and @entity1827 increased after repeated CCI4 injections. @entity1710 and @entity1711 staining showed thickened portal vein walls, with increased inside and outside diameters. Electron microscopy revealed different degrees of endothelial cell degeneration, destruction of basement membrane integrity, proliferating, and @entity1184 smooth muscle cells. Conclusions. Fluid shear stress not only influenced the biomechanical environment of the portal vein but also participated in vascular remodeling.
