Two cases of XXXX .

@entity1 @entity410 @entity693 @entity51 @entity911 @entity10 @entity1118 @entity309 @entity288
UNASSIGNED: Central nervous system (CNS) involvement by @entity309 ( @entity309 ) in the form of @entity693 ( @entity693 ) is rare and most commonly occurs in the setting of longstanding severe @entity309 . Due to a wide range of clinical presentations and nonspecific laboratory findings, it presents a diagnostic challenge often requiring brain biopsy. Only a few histopathologically confirmed cases have been described in the literature. Our aim is to describe two cases of @entity693 and review the literature. The first case is of a previously healthy 37-year-old @entity1 who presented with severe @entity10 and focal @entity51 . Magnetic resonance imaging demonstrated abnormal leptomeningeal enhancement in the left frontal and parietal sulci. The second case is of a 62-year-old @entity1 with a history of mild @entity1118 who presented with @entity911 , personality changes and @entity410 . Both @entity1 ultimately underwent brain biopsy which demonstrated @entity693 on pathologic examination. Administration of @entity288 resulted in significant clinical improvement in both cases. To our knowledge, our unusual case of @entity693 in the young @entity1 is the fifth reported case of @entity693 in a @entity1 with no prior history of @entity309 . Such an atypical presentation makes diagnosis even more difficult and highlights the need for awareness of this entity in the diagnostic consideration of a @entity1 presenting with unexplained neurologic symptoms. Our literature review underscores the clinical and pathologic heterogeneity of CNS involvement in @entity309 .
