Effects on indicators of tissue perfusion in XXXX anesthetized with @entity5161 at two multiples of the minimum alveolar concentration.

@entity235 @entity26 @entity880 @entity5161 @entity590
UNASSIGNED: OBJECTIVE To investigate the effects of @entity5161 @entity590 administered at 2 multiples of the minimum alveolar concentration (MAC) on tissue perfusion in @entity235 . ANIMALS 8 healthy young adult Beagles. PROCEDURES A randomized crossover design was used. @entity235 were anesthetized with @entity5161 at 1.5 or 2.0 times the MAC for 2 hours, a 7-day washout period was provided, and @entity235 were reanesthetized with the alternate treatment. Various physiologic variables were monitored before @entity590 (baseline), at 20-minute intervals during @entity590 , and after anesthetic recovery. Variable values were compared between MAC multiples by means of repeated-measures ANOVA, with the Tukey test used for multiple comparisons. RESULTS During @entity590 , mean arterial blood pressure, cardiac output, and mixed venous @entity26 saturation were significantly greater when @entity5161 was administered at 1.5 versus 2.0 times the MAC. Cardiac output gradually increased during @entity590 at 1.5 times but not at 2.0 times the MAC. Arterial blood @entity880 concentration did not differ between MAC multiples at any point; however, this concentration decreased with increasing anesthetic duration at both MAC multiples. @entity26 delivery differed between MAC multiples, and @entity26 consumption differed from baseline during @entity590 at 2.0 times the MAC. @entity26 extraction was higher at 2.0 versus 1.5 times the MAC. Heart rate differed between MAC multiples only after anesthetic recovery. CONCLUSIONS AND CLINICAL RELEVANCE @entity5161 @entity590 impaired tissue perfusion in @entity235 , but these changes would not be clinically relevant with @entity26 delivery at 100%. Peripheral tissue perfusion was maintained or improved with time.
