Clinical review: Diagnosis and treatment of subclinical XXXX .

@entity1 @entity101 @entity6 @entity28 @entity170 @entity700 @entity699 @entity701 @entity774
CONTEXT: Subclinical @entity699 (SH) is a condition of biochemical @entity701 excess without the classical signs or symptoms of overt @entity699 . It is thought to be present in the 5-30% of @entity1 with incidentally discovered @entity774 ( @entity700 ), which in turn are found in 4-7% of the adult population. Therefore, SH has been suggested to be present in 0.2-2.0% of the adult population. Some studies suggested that this condition is present in 1-10% of @entity1 with @entity6 or established @entity170 . The present manuscript reviews the literature on diagnostic procedures and the metabolic effect of the recovery from SH. EVIDENCE ACQUISITION: A PubMed search was used to identify the available studies. The most relevant studies from 1992 to November 2010 have been included in the review. EVIDENCE SYNTHESIS: The available data suggest that SH may be associated with chronic complications, such as @entity101 , @entity6 , overweight/ @entity28 , and @entity170 . The available intervention studies suggest that the recovery from SH may lead to the improvement of @entity101 and @entity6 . A retrospective study suggests that this beneficial effect could be predicted before surgery. CONCLUSIONS: SH is suggested to be associated with some chronic complications of overt @entity701 excess. Recovery from this condition seems to improve these complications. However, a large, prospective, randomized study is needed to confirm this hypothesis and to establish the best diagnostic approach to identify @entity1 with @entity700 who can benefit from surgery.
