The significance of serum XXXX elevation in malignant and nonmalignant diseases.

@entity43 @entity1 @entity0 @entity5344 @entity5 @entity2 @entity10224 @entity204
OBJECTIVES: The aims of the study were to investigate whether an elevated @entity10224 level signals @entity43 and to find the cause of @entity204 for 247 @entity1 with elevated values among the 5550 @entity1 screened in 1986-1988 in the Stockholm population. METHODS: The Swedish Regional @entity5 Registry delivered malignancy diagnoses among the 5550 @entity1 screened. The Cause of Death Registry gave the cause of @entity204 among the @entity1 with elevated @entity10224 values. RESULTS: @entity1 with @entity43 were excluded. In 44 @entity1 with elevated @entity10224 values other @entity5 were reported to the @entity5 Registry. They represent 18% of the entire group with elevated values. Among the 5297 @entity1 with normal @entity10224 values 13% developed various @entity5 . The difference between incidence of @entity5 in @entity1 with elevated values and @entity1 with normal values is significant, P = 0.02. Especially during the test-related period, from 1 year before to 1 year after the test, @entity5 were detected in 6.9% of the population with elevated values and in only 1.6% with normal values (P = < 0.001). @entity0 and @entity2 were overrepresented among @entity1 with elevated @entity10224 values (P = 0.015 and < 0.001, respectively). Of the total 5500 @entity1 screened, 358 @entity1 died with different diagnoses. Elevated @entity10224 values had been noted earlier in 25 @entity1 , and of these 20 died of @entity5344 . CONCLUSIONS: Asymptomatic postmenopausal @entity1 with elevated @entity10224 levels in @entity43 screening trials should, if @entity43 is excluded, be investigated for possible @entity0 . The findings also suggest that elevated @entity10224 level is a risk factor for @entity204 from @entity5 .
