Shared and distinct genetic variants in XXXX .

@entity1 @entity31693 @entity1593 @entity6 @entity31692 @entity3145 @entity1723 @entity10669 @entity15842 @entity2902 @entity5812 @entity20870 @entity4386 @entity31694
BACKGROUND: Two inflammatory disorders, @entity1723 , cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared. METHODS: We evaluated the association between type 1 @entity6 and eight loci related to the risk of @entity1593 by genotyping and statistical analyses of DNA samples from 8064 @entity1 with type 1 @entity6 , 9339 control subjects, and 2828 families providing 3064 parent- @entity1 trios (consisting of an affected @entity1 and both biologic parents). We also investigated 18 loci associated with type 1 @entity6 in 2560 @entity1 with @entity1593 and 9339 control subjects. RESULTS: Three @entity1593 loci-- @entity20870 on chromosome 1q31, @entity31692 on chromosome 2q12, and @entity31693 on chromosome 6q25--were associated with type 1 @entity6 (P<1.00x10(-4)). The 32-bp insertion-deletion variant on chromosome 3p21 was newly identified as a type 1 @entity6 locus (P=1.81x10(-8)) and was also associated with @entity1593 , along with @entity15842 on chromosome 18p11 and @entity4386 on chromosome 2q33, bringing the total number of loci with evidence of a shared association to seven, including @entity31694 on chromosome 12q24. The effects of the @entity31692 and @entity31693 alleles confer protection in type 1 @entity6 and susceptibility in @entity1593 . Loci with distinct effects in the two diseases included INS on chromosome 11p15, @entity2902 on chromosome 10p15, and @entity5812 on chromosome 1p13 in type 1 @entity6 and @entity10669 on 3q25 and LPP on 3q28 in @entity1593 . CONCLUSIONS: A genetic susceptibility to both @entity1723 shares common alleles. These data suggest that common biologic mechanisms, such as @entity3145 and intolerance to dietary antigens, may be etiologic features of both diseases.
