Morning Blood Pressure Surge, Dipping, and Risk of Coronary Events in Elderly Treated XXXX @entity1 .

@entity1 @entity7127 @entity101
BACKGROUND: The independent prognostic significance of @entity7127 ( @entity7127 ) of blood pressure (BP) is not yet clear. We investigated the association between @entity7127 of systolic BP and risk of coronary events in elderly treated @entity101 @entity1 . METHODS: The occurrence of coronary events was evaluated in 1,191 elderly treated @entity101 @entity1 (age range 60-90 years). Subjects were divided according to tertiles of @entity7127 of systolic BP of the population as a whole, by dipping status and by group-specific tertiles of @entity7127 of systolic BP in dippers and nondippers. RESULTS: During the follow-up (9.1    4.9 years, range 0.4-20 years), 120 coronary events occurred. In the population as a whole, coronary event risk was not significantly associated with tertiles of @entity7127 of systolic BP, whereas nondippers were at higher risk than dippers. When nondippers and dippers were analyzed separately, by group-specific tertiles of @entity7127 of systolic BP, coronary event risk was associated with @entity7127 of systolic BP in dippers but not in nondippers. After adjustment for various covariates, Cox regression analysis showed that dippers in the third tertile (>23 mm Hg) of @entity7127 of systolic BP (hazard ratio 1.912, 95% confidence interval 1.048-3.488, P = 0.03) and nondippers (hazard ratio 1.739, 95% confidence interval 1.074-2.815, P = 0.02) were at higher coronary event risk than dippers with @entity7127 of systolic BP <23 mm Hg . CONCLUSIONS: In elderly treated @entity101 @entity1 , high @entity7127 of systolic BP predicts coronary events in dippers but not in nondippers. Nondippers, however, show higher risk of coronary events independently of @entity7127 in systolic BP.
