The role of heregulin-alpha as a motility factor and XXXX as a growth factor in wound healing.

@entity1915 @entity0 @entity7514 @entity470 @entity12251 @entity33 @entity105 @entity1722
Wound healing is a complex process of which growth and motility are essential features. The aim of this study was to search for keratinocyte-derived secreted factors that may play a role in these mechanisms, and their corresponding receptors. Growth and motility factors were purified from conditioned medium from cultured primary keratinocytes. Receptor and growth factor expression profiles were investigated by immunohistochemical, western blotting, and in situ hybridization analysis on cultured keratinocytes and tissue sections derived from chronic wounds. The most potent autocrine growth factor for keratinocytes, which it was possible to purify and sequence from keratinocyte-conditioned medium, is @entity1915 . Its receptor @entity470 is up-regulated on the membranes of keratinocytes lining the edge of the wound. From the same keratinocyte-conditioned medium, heregulin-alpha was purified as a potent motility factor for keratinocytes. Its receptor is @entity7514 , which is up-regulated on the membranes of keratinocytes lining the edge of the wound and on keratinocytes that had migrated towards the centre of the wound. @entity12251 - another receptor for heregulin-alpha - is weakly present in occasional cells near the edge of the wound. The co-receptor for @entity7514 and @entity12251 is @entity1722 , which is also present in epidermal cells but not overexpressed. This study shows that heregulin-alpha is a potent motility factor for normal epithelial cells and that it plays a central role in the process of wound healing of stratified epithelia. Heregulin-alpha has already been shown to be the motility factor leading to migration of @entity1722 / @entity1722 -overexpressing @entity0 cells. The role of @entity1915 as a growth factor and of heregulin-alpha as a motility factor for keratinocytes in epidermal and @entity33 healing parallels their motility and growth induction in @entity105 .
