Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic XXXX .

@entity1 @entity3821 @entity0 @entity5 @entity470 @entity6881 @entity1722
UNASSIGNED: @entity0 is the most common @entity5 in Singapore @entity1 . @entity3821 ( @entity3821 ) is the putative, non-obligate precursor of the majority of invasive @entity0 . The efficacy of the Singapore breast-screening pilot project in detecting early stage @entity0 led to the launch of a national breast-screening programme, BreastScreen Singapore (BSS), in January 2002. In this study, we compared clinicopathological and immunohistochemical characteristics, as well as clinical outcomes, between screen-detected and symptomatic @entity3821 . The study cohort comprised 1202 cases of @entity3821 diagnosed at Singapore General Hospital from 1994 to 2010. Comparison of clinicopathological parameters, immunohistochemical results of ER, PR, @entity1722 , @entity6881 , @entity470 , and 34bE12, and clinical outcomes was carried out between the 2 groups. Amongst 1202 cases, 610 (50.7  %) were screen-detected and 592 (49.3  %) were symptomatic @entity3821 . Screen-detected cases were smaller in size (P  <  0.001), of lower nuclear grade (P  =  0.004), and more frequently expressed ER (P  <  0.001). Luminal A phenotype was more frequently observed in screen-detected @entity3821 , while triple-negative and @entity1722 phenotypes were more common in symptomatic @entity3821 (P  <  0.001). The basal-like phenotype was also more frequent in symptomatic @entity3821 (P  =  0.041). Mean and median follow-up was 99.7 and 97.8  months, respectively, with a maximum follow-up of 246.0  months. More symptomatic @entity1 developed invasive recurrences compared to screen-detected @entity1 (P  =  0.001). A trend for better disease-free survival was observed in screen-detected @entity1 (P  =  0.076). @entity1 who were screen-detected experienced better overall survival than those with symptomatic @entity3821 (P  =  0.007). Our data indicate a more  favourable outcome of screen-detected @entity3821 @entity1 confirming the role of BSS in early identification of this curable  disease.
