Roles of @entity72138 , a new heterocyclic hormone of the adrenals, and XXXX , a thymothyroid hormone, in the formation of blood cells.

@entity35 @entity72137 @entity1014 @entity72138
Treatment of normal @entity35 with the thymothyroid hormone @entity72137 accelerates the rate at which the 'functional' cells, neutrophils, red blood cells and lymphocytes, develop in the bone marrow from their corresponding committed precursor cells. Following the initial treatment of normal @entity35 with @entity72137 , there is a temporary elevation in the bone marrow of the relative concentrations of myeloblasts, rubriblasts and lymphoblasts. It has now been found that bilaterally adrenalectomized @entity35 have a different response from normal @entity35 to treatment with @entity72137 . Although treatment of bilaterally adrenalectomized @entity35 with @entity72137 accelerates the rate of development of their functional cells, the initial injection of @entity72137 is followed by a temporary decrease in the relative concentrations of myeloblasts, rubriblasts and lymphoblasts in their bone marrow. Additionally, adrenalectomized @entity35 treated concurrently with tritiated @entity1014 and @entity72137 show a significant lower percentage of labeled cells in their bone marrow than do correspondingly treated normal @entity35 . These results indicate that adrenalectomized @entity35 have a lower than normal concentration of stem cells in their bone marrow that can be committed to become functional cells. Treatment with @entity72138 , a new recently isolated heterocyclic hormone of the adrenals, causes adrenalectomized @entity35 to respond as normal @entity35 to the injection of @entity72137 . There is a temporary elevation of myeloblasts, rubriblasts and lymphoblasts in their bone marrow as well as a normal increase in the percentage of cells that are labeled following concurrent treatment with tritiated @entity1014 and @entity72137 . It may be concluded that treatment with @entity72138 increases the rate of replication of uncommitted bone marrow stem cells while treatment with @entity72137 increases the rate at which committed cells develop into their respective functional cells. A scheme is presented to show the suggested roles that @entity72137 and @entity72138 play in regulating the formation of blood cells.
