@entity5 mortality and incidence of mesothelioma in a cohort of wives of XXXX workers in Casale Monferrato, Italy.

@entity1 @entity5 @entity2 @entity3620 @entity1355
BACKGROUND: Family members of @entity1355 workers are at increased risk of @entity3620 ( @entity3620 ). Although the hazard is established, the magnitude of the risk is uncertain, and it is unclear whether risk is also increased for other @entity5 . Few cohort studies have been reported. OBJECTIVE: The "Eternit" factory of Casale Monferrato (Italy), active from 1907 to 1986, was among the most important Italian plants producing @entity1355 -cement (AC) goods. In this article we present updated results on mortality and @entity3620 incidence in the wives of workers at the factory. METHODS: We studied a cohort of 1,780 @entity1 , each married to an AC worker during his employment at the factory but not personally occupationally exposed to @entity1355 . Cohort membership was defined starting from the marital status of each worker, which was ascertained in 1988 from the Registrar's Office in the town where workers lived. At the end of follow-up (April 2003), 67% of @entity1 were alive, 32.3% dead, and 0.7% lost to follow-up. Duration of exposure was computed from the husband's period of employment. Latency was the interval from first exposure to the end of follow-up. RESULTS: The standardized mortality ratio (SMR) for @entity5 [21 observed vs. 1.2 expected; SMR = 18.00; 95% confidence interval (CI), 11.14-27.52] was significantly increased. @entity2 was not increased (12 observed vs. 10.3 expected; SMR = 1.17; 95% CI, 0.60-2.04). Eleven incident cases of pleural @entity3620 were observed (standardized incidence ratio = 25.19; 95% CI, 12.57-45.07). CONCLUSIONS: Household exposure, as experienced by these AC workers' wives, increases risk for pleural @entity3620 but not for @entity2 .
