The Impact of Aerobic Exercise on XXXX and Neurocognition in Individuals With @entity161 : A Single-Blind, Randomized Clinical Trial.

@entity1 @entity410 @entity149 @entity161 @entity2252
UNASSIGNED: Individuals with @entity161 display @entity149 for which available treatments offer only limited benefits. Yet, findings from studies of animals, clinical and nonclinical populations have linked neurocognitive improvements to increases in @entity410 ( @entity410 ) via aerobic exercise training (AE). Such improvements have been attributed to up-regulation of @entity2252 ( @entity2252 ). However, the impact of AE on neurocognition, and the putative role of @entity2252 , have not been investigated in @entity161 . Employing a proof-of-concept, single-blind, randomized clinical trial design, 33 individuals with @entity161 were randomized to receive standard psychiatric treatment (n = 17; "treatment as usual"; TAU) or attend a 12-week AE program (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. @entity1 completed assessments of @entity410 (indexed by VO2 peak ml/kg/min), neurocognition (MATRICS Consensus Cognitive Battery), and serum- @entity2252 before and after and 12-week period. Twenty-six @entity1 (79%) completed the study. At follow-up, the AE @entity1 improved their @entity410 by 18.0% vs a -0.5% decline in the TAU group (P = .002) and improved their neurocognition by 15.1% vs -2.0% decline in the TAU group (P = .031). Hierarchical multiple regression analyses indicated that enhancement in @entity410 and increases in @entity2252 predicted 25.4% and 14.6% of the neurocognitive improvement variance, respectively. The results indicate AE is effective in enhancing neurocognitive functioning in @entity1 with @entity161 and provide preliminary support for the impact of AE-related @entity2252 up-regulation on neurocognition in this population. Poor @entity410 represents a modifiable risk factor for @entity149 in @entity161 for which AE training offer a safe, nonstigmatizing, and side-effect-free intervention.
