Preoperatively irradiated @entity189 : analysis of the histopathologic response and predictive value of XXXX immunostaining.

@entity5 @entity189 @entity1364 @entity876
OBJECTIVES: To investigate the relationship between the histopathologic effects of preoperative chemoradiotherapy in @entity5 and the proteins, @entity1364 ( @entity1364 ) and @entity876 . METHODS: Samples from 73 @entity5 were examined. The histopathologic effects observed in the resected specimens induced by preoperative chemoradiotherapy were correlated with the inmunohistochemical expression of @entity1364 and @entity876 in biopsies obtained by rectoscopy before chemoradiotherapy. RESULTS: Thirty-five @entity5 showed a high @entity1364 index (48%). Nuclear accumulation of @entity876 protein was detected in 53 @entity5 (72%). Specimens were assigned one of four grades based on the amount of residual viable @entity5 . Three @entity5 (4%) showed complete regression; 8 other @entity189 (11%) showed only small numbers of @entity5 cells scattered within the field of stromal reaction. In these cases, it was considered that the @entity5 had responded significantly to radiotherapy. @entity5 with a high @entity1364 index responded to chemoradiotherapy more frequently (8/35; 72%) than @entity5 with a low index (3/38; 43%) (p = 0.07). @entity876 -negative @entity5 responded more frequently (4/20; 20%) than positive @entity5 (7/53; 13.2%) (p = 0.50). When pathologic and immunohistochemical characteristics of the @entity5 were included in a logistic regression model, only high @entity1364 index (odds ratio 5.35, 95% confidence interval 1.07-26.7) (p = 0.04) was significantly associated with the histologic response to preoperative chemoradiotherapy. CONCLUSION: High proliferative activity of @entity5 , as determined by @entity1364 immunostaining, is predictive of the response to preoperative chemoradiotherapy.
