Association of XXXX genotype and common cardiovascular risk factors with the amount of @entity68 in atherosclerotic carotid plaques.

@entity1 @entity66 @entity6 @entity2104 @entity1255 @entity543 @entity68
INTRODUCTION: The aim of this study was to evaluate the @entity68 burden of carotid atherosclerotic plaques removed from @entity1 treated for @entity66 and find any relation with @entity2104 genotype and other common cardiovascular risk factors. METHODS: Consecutive @entity1 undergoing carotid endarterectomy were included in the study. All @entity1 had high-grade @entity543 (>70%). The clinical characteristics and serum parameters of the study population were recorded and the @entity2104 genotype was determined. The presence of hemosiderin deposits in the plaques was identified using Perl's stain on adjacent serial sections. RESULTS: 70 specimens were processed for histologic examination: 27 plaques from @entity6 @entity1 (16 with the Hp 1-1 or 2-1 genotype and 11 with the Hp 2-2 genotype) and 43 plaques from non @entity6 @entity1 (20 with the Hp 1-1 or 2-1 genotype and 23 with the Hp 2-2 genotype). In plaques from @entity6 @entity1 the density of Perl's @entity68 stain was significantly higher in the Hp 2-2 group compared with that in the Hp 1-1 or 2-1 group (p = 0.008). The correlation and regression analysis of all possible clinical and laboratory predictors of intraplaque @entity68 deposition showed that four factors were independently associated with intraplaque @entity68 deposition: male gender, serum @entity1255 , Hp 2-2 genotype and @entity6 treatment. CONCLUSIONS: Male @entity6 @entity1 with increased plasma levels of @entity1255 and the Hp 2-2 genotype had higher carotid plaque @entity68 deposition. Current evidence and pathophysiological considerations suggest that the increased intraplaque @entity68 deposition may be associated with increased oxidative stress, affecting the stability of the carotid plaque.
