Risk factors associated with XXXX following allogeneic bone marrow transplantation for acute leukemia in Japanese experience.

@entity1 @entity981 @entity786 @entity3052 @entity281 @entity348 @entity2834 @entity401
Records of 101 @entity1 with @entity3052 who received allogeneic bone marrow transplantation (BMT) with preparation using @entity786 and @entity348 ( @entity348 ) from September 1975 through July 1984 were collected into Japanese Bone Marrow Transplant Registry from 15 of the participating hospitals. These @entity1 were divided into two groups by year of BMT. Group I included nine @entity981 ( @entity981 ) and nine @entity981 ( @entity981 ) @entity1 who received BMT before 1980. Group II consisted 39 @entity981 and 44 @entity981 @entity1 who were treated after 1981. One-year survivals were 11% and 58% in groups I and II, respectively (p less than 0.001). Probabilities of developing @entity401 at one year were 93% and 37% in groups I and II, respectively (p less than 0.001). Of 14 @entity1 who developed @entity401 in group I, twelve (86%) died of @entity401 . Fifteen of 22 (68%) were fatal in group II. Using proportional hazard regression model, year of BMT (p = 0.0001) and selection of platelet donor with negative cytomegalovirus ( @entity2834 ) titer (p = 0.0215) were found to be significant risk factors associated with @entity401 . The present analysis indicated that change in the selection of @entity1 , e.g., in remission without @entity281 at the time of BMT, as well as treatment modality, e.g., fractionated @entity348 , and selection of platelet donor with negative @entity2834 titer, resulted in the significant improvement in the survival and decreased incidence of @entity401 .
