The role of neuroendocrine system in the pathogenesis of XXXX (minireview).

@entity1 @entity627 @entity2990 @entity409 @entity2124 @entity1636 @entity9027 @entity309
Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. In susceptible individuals a dysfunction of the neuroendocrine system may be one of the risk factors involved in the pathogenesis of @entity627 . Specific causes of altered neuroendocrine function are still not fully elucidated. Accumulation of genetical, environmental, behavioral and other risk factors during long preclinical period may result in chronic imbalances in homeostatic mechanisms maintained by neuroendocrine, microvascular and immune systems. Chronic inflammatory stress mediated by humoral and neural signals during active stages of the disease and autoantibodies against the structures of the neuroendocrine system may further participate in the @entity409 . In a subset of @entity1 with @entity309 ( @entity309 ), an assumed defect of the @entity1636 may be implicated in the pathogenesis. Results of some studies support the concept of @entity409 in @entity1 with premenopausal onset of the @entity309 . Significantly lower levels of @entity9027 ( @entity2990 ) plasma levels of @entity1 who subsequently developed @entity309 indicate that @entity409 may be present already in preclinical period and thus are not only secondary due to ongoing inflammatory process. These findings are sketching the new prospects of possible primary prevention of @entity309 in the future. The role of some other hormones including prolactin, @entity2124 , sex hormones and involvement of autonomic nervous system in relation with the @entity627 is also reviewed in the paper. Further research concerning their role in the pathogenesis of other @entity627 will possibly provide new prospects in optimizing their therapy.
