A clinical study of XXXX osteochondroplastica: findings from a large Chinese cohort.

@entity1 @entity32 @entity854 @entity21159 @entity9384
BACKGROUND AND STUDY AIMS: @entity21159 ( @entity21159 ) is an uncommon disease of the tracheobronchial system that leads to narrowing of the airway lumen from @entity9384 . The aim of this study is to perform a detailed review of this rare disease in a large cohort of @entity1 with @entity21159 proven by fiberoptic bronchoscopy from China. @entity1 AND METHODS: Retrospective chart review was performed on 41,600 @entity1 who underwent bronchoscopy in the Department of Respiratory Medicine of Changhai Hospital between January 2005 and December 2012. Cases of @entity21159 were identified based on characteristic features during bronchoscopic examination. RESULTS: 22 cases of bronchoscopic @entity21159 were identified. Among whom one-half were male and the mean age was 47.45  10.91 years old. The most frequent symptoms at presentation were chronic cough (n=14) and increased sputum production (n=10). @entity854 were observed in 3/18 @entity1 and findings on computed tomography consistent with @entity21159 such as beaded intraluminal calcifications and/or increased luminal thickenings were observed in 18/22 @entity1 . @entity1 were classified into the following categories based on the severity of bronchoscopic findings: Stage I (n=2), Stage II (n=6) and Stage III (n=14). The result that bronchoscopic improvement was observed in 2 @entity1 administered with inhaled corticosteroids suggested that resolution of this disease is possible. CONCLUSIONS: @entity21159 is a benign disease with slow progression, which could be roughly divided into 3 stages on the basis of the characteristic endoscopic features and histopathologic findings. @entity32 was thought to be more important than the other existing plausible hypotheses in the course of @entity21159 . Inhaled corticosteroids might have some impact on @entity1 at Stage I/II.
