Treatment of XXXX with Alternative Therapies (THAT) Study: a randomized clinical trial.

@entity1 @entity551 @entity101
OBJECTIVES: To examine the effect of spinal manipulation on blood pressure. DESIGN: This randomized clinical trial compared the effects of chiropractic spinal manipulation and diet with diet alone for lowering blood pressure in @entity1 with high-normal blood pressure or stage I @entity101 . Blood pressure observers were blinded to treatment group. SETTING: The study was conducted at the Berman Center for Clinical and Outcomes Research in Minnesota. Chiropractic treatments were administered by chiropractic physicians within private practice settings. @entity1 One hundred and forty @entity1 and @entity1 , aged 25-60 years, with high-normal blood pressure or stage I @entity101 , were enrolled. One hundred and twenty-eight @entity1 completed the study. INTERVENTIONS: (i) A dietary intervention program administered by a dietitian or (ii) a dietary intervention program administered by a doctor of chiropractic in conjunction with chiropractic spinal manipulation. The frequency of treatment for both groups was three times per week for 4 weeks, for a total of 12 visits. MAIN OUTCOME MEASURES: The primary outcomes for this study were change from baseline in @entity551 . RESULTS: Study groups were comparable at baseline. Changes in potentially confounding covariates did not differ between groups. Average @entity551 were -4.9/5.6 mmHg for diet group and -3.5/4.0 mmHg for the chiropractic group. Between group changes were not statistically significant. CONCLUSIONS: For @entity1 with high normal blood pressure or stage I @entity101 , chiropractic spinal manipulation in conjunction with a dietary modification program offered no advantage in lowering either @entity551 compared to diet alone.
