@entity1 kallikrein 10 in surgically removed XXXX @entity977 .

@entity1 @entity22547 @entity1637 @entity1885 @entity5 @entity406 @entity189 @entity1943 @entity977 @entity74 @entity563 @entity2390 @entity652
OBJECTIVE: @entity1 @entity22547 ( @entity22547 ), a @entity563 protease, plays an important role in the regulation of cell proliferation and @entity5 growth. In this work, we investigated @entity22547 immunoexpression in various types of surgically removed @entity1 @entity977 . DESIGN: Specimens were fixed in @entity406 and embedded in paraffin. Immunostaining was performed by the streptavidin- @entity1885 -peroxidase complex protocol using the LSAB+ Kit and a @entity22547 -specific rabbit polyclonal antibody. RESULTS: Results showed that both treated and untreated prolactin-producing @entity977 as well as TSH-producing @entity977 were conclusively immunopositive for @entity22547 . Immunostaining was mainly localized in the cytoplasm and was clearly visible in many @entity652 cells. In various other @entity5 types ( @entity1637 , gonadotroph, somatotroph @entity652 , and @entity189 ), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed @entity652 cells. Immunopositivity in the nuclei of various @entity5 types, as well as dual cytoplasmic and nuclear localization of @entity22547 in some of the @entity5 types, was an intriguing finding. Immunoexpression in GH-producing @entity652 exposed to @entity2390 , a long-acting @entity1943 analog, was significantly increased when compared to unexposed GH-producing @entity5 . CONCLUSION: More studies are needed to ascertain the role of @entity22547 in @entity977 development, prognosis, and progression. The question of whether @entity74 and the microenvironment can affect @entity22547 immunoexpression should also be investigated.
