Effect of lipid profile on prognosis in the XXXX with amyotrophic lateral sclerosis: Insights from the @entity31435 clinical trial.

@entity1 @entity31435 @entity2655 @entity4053 @entity2495 @entity1282 @entity165
UNASSIGNED: @entity1 with @entity2655 may have insufficientenergy substrates, due to @entity1282 and @entity2495 , which adversely affects the prognosis. Hyperlipidaemia has been reported to be associated with @entity2655 and to represent a significant prognostic factor for survival in @entity2655 . The aim of this study was to examine the prevalence of dyslipidaemia among a cohort of @entity1 with @entity2655 and how the lipid profile of @entity1 with @entity2655 influenced the prognosis. This was a prospective observational cohort study comprising 512 @entity2655 @entity1 , recruited for the @entity31435 ( @entity31435 ) investigational medicinal product trial. @entity4053 serum concentrations of total @entity165 (TC), low density lipoprotein @entity165 (LDL-C) and high density lipoprotein @entity165 (HDL-C) were measured as part of routine monitoring in the trial. Seventy-three percent of the @entity1 had hypercholesterolaemia (defined as total @entity165 >=  5.1 mmol/l) at the screening visit. The prevalence of hypercholesterolaemia decreased with time and was 64% at 18 months follow-up. On unadjusted analysis total @entity165 , LDL-C and LDL/HDL ratio had a statistically significant effect on survival (p = 0.015, 0.003 and 0.027, respectively). When adjusted for prognostic covariates, however, none of the lipid measures was found to have a statistically significant effect on survival. In conclusion, prognosis in @entity2655 is not influenced by the lipid profile of @entity1 .
