A prospective study of thyroid function, morphology and autoimmunity in young XXXX with type 1 @entity6 .

@entity1 @entity6 @entity1669 @entity1955 @entity854 @entity1954 @entity1374
OBJECTIVE: Thyroid autoantibodies (TA) and thyroid ultrasonography are widely used in the diagnosis of @entity1669 ( @entity1669 ). However, we know little of the significance of having @entity854 ( @entity854 ) without having any other signs of @entity1669 . In a previous population-based study of 105 young @entity1 with type 1 @entity6 (T1DM) we found a high prevalence (42%) of @entity854 . In the present study we evaluate the development of both @entity854 and TA in a 3-Year follow-up of this cohort. DESIGN: Of the 105 previously investigated @entity1 and adolescents with T1DM (aged 5-21 Years), 101 were re-examined. Serum concentrations of @entity1954 (T(3)), @entity1955 (T(4)), TSH, thyroid peroxidase antibodies (TPOab) and thyroglobulin antibodies (Tgab), as well as thyroid size and morphology were determined in all @entity1 . RESULTS: During the 3 Years follow-up period, the prevalence of @entity1374 increased from 5 to 8%, the prevalence of TPOab was unchanged at 13%, while the prevalence of Tgab decreased from 14 to 7%. The prevalence of @entity854 increased from 42 to 49%. Most @entity1 presented @entity854 at both examinations. @entity1 with @entity854 had a higher prevalence of TA than those without @entity854 (P=0.038) and higher serum levels of TSH (P=0.027). All @entity1 with @entity1374 presented with @entity854 . However, many @entity1 with @entity854 had no other signs of @entity1669 . CONCLUSIONS: A high prevalence of @entity1374 , TA and thyroid @entity854 were found in young @entity1 with T1DM. Thyroid @entity854 was a sensitive but non-specific marker of @entity1669 and is therefore unsuitable for screening purposes. Instead, we recommend regular screening using serum TSH in the follow-up of young @entity6 @entity1 .
