[Effects of esophageal distension on XXXX pancreatic exocrine secretion].

@entity2997 @entity4486 @entity235 @entity3157 @entity3897 @entity16340
The pancreatic exocrine secretion responses to distension of the thoracic oesophagus were studied in @entity4486 anesthetized @entity235 and decerebrated @entity235 occluded the pyloric sphincter with submucosal ligature. In 79 of 149 distensions, the pancreatic outflow was increased by 70.6% of control value before the distension with latencies of one to five minutes. This response was accompanied by the increased protein and @entity3157 outputs of 83.1% and 303.0% of control value, respectively. In 68 of 149 distensions, the pancreatic outflow, protein and @entity3157 outputs were decreased by 23.2%, 17.1% and 29.1% of control value, respectively. After transthoracic vagotomy immediately above the diaphragm or administration of @entity3897 , the increased response was abolished, but the decreased one was not. The decreased response was markedly reduced by @entity2997 , and completely abolished after following adrenalectomy. Furthermore, it was completely abolished after splanchnicotomy, too. There was no relationship between the pancreatic exocrine secretion and the serum @entity16340 concentration before and after distension of the oesophagus. These results provide an evidence for the existence of the oesophago-pancreatic excitatory and inhibitory responses. The excitatory one is due to the vago-vagal reflex and the inhibitory one is due to the vago-splanchnic reflex.
