Postoperative Complications Affect Long-Term Survival Outcomes Following Hepatic Resection for XXXX .

@entity1 @entity66 @entity260 @entity14 @entity1349
BACKGROUND: The impact of @entity260 ( @entity260 ) on long-term survival outcomes following hepatic resection for @entity14 ( @entity14 ) is in controversy. The aim of the present meta-analysis was to systematically evaluate the POC effect on @entity1349 ( @entity1349 ) and @entity66 ( @entity66 ) in @entity1 undergoing hepatic resection for @entity14 . METHODS: We conducted a systematic review and meta-analysis of all observational studies to evaluate the POC effect on @entity1349 and @entity66 in @entity1 undergoing hepatic resection for @entity14 . A search for all major databases and relevant journals from inception to January 2014 without restriction on languages or regions was performed. @entity260 were extracted and graded according to a validated system of classification. Outcome measures were postoperative 1-, 2-, 3-, and 10-year OSs and DFSs. Both random-effects and fixed-effect models were used to pool the hazard ratios (HRs) of the survival outcomes. Test of heterogeneity was performed with the Q statistic. RESULTS: A total of 2370 @entity1 were included in the meta-analysis. Both 5- and 10-year postoperative OSs showed significant decreases in @entity1 with @entity260 (HR  =  1.52; 95  % CI 1.27-1.83; P  <  0.001 and HR  =  1.36; 95  % CI 1.18-1.58; P  <  0.001, respectively). Similar outcomes were also observed in terms of DFSs, with the 5- and 10-year HRs found to be 1.37 (95  % CI 1.23-1.53; P  <  0.001) and 1.34 (95  % CI 1.17-1.53; P  <  0.001), respectively, compared to no POC group. CONCLUSIONS: @entity260 are strongly related to long-term oncologic outcomes following hepatic resection for @entity14 . Further efforts to refine surgical technique and postoperative management to avoid complications may improve the long-term oncological outcomes of the selected @entity1 .
