Potential influence of in utero and early neonatal exposures on the later development of XXXX .

@entity1 @entity3465 @entity532 @entity46 @entity1468 @entity20428 @entity2909
OBJECTIVE: To investigate the possible correlation between maternal characteristics, in utero and early neonatal life exposures, and the development of @entity46 in adult life. DESIGN: Case-control study. SETTING: University hospital. @entity1 (S): A group of 161 @entity1 with @entity46 and a control group of 230 @entity1 undergoing laparoscopy for benign @entity20428 and free of @entity46 . INTERVENTION(S): All @entity1 included in the study were requested to answer a series of questions about their mothers' gestational data and on their own perinatal and early postnatal lives. MAIN OUTCOME MEASURE(S): Odds ratio, adjusted odds ratios, and 95% confidence intervals for the associations between maternal characteristics during the @entity1 's pregnancy, in utero exposure to @entity532 , and the type of feeding received during the neonatal period with the development of @entity46 in adult life. RESULT(S): Mothers of @entity1 with @entity46 were significantly more likely to be affected by @entity2909 , with a higher incidence of smoking during pregnancy. @entity1 with @entity46 were more frequently born prematurely, with a significantly lower birth weight, and their mothers experienced @entity1468 during their pregnancies more often than control subjects. They were also more frequently formula fed than breast fed in early life. However, only @entity3465 and formula feeding were retained in the multivariate analysis model. CONCLUSION(S): Among intrauterine and early neonatal exposures, @entity3465 and formula feeding were risk factors for the development of @entity46 in adult life. Further studies should evaluate the underlying biologic mechanisms.
