Plasma soluble XXXX receptor-1 levels predict outcomes of @entity55 -related @entity326 @entity1 : a prospective observational study.

@entity1 @entity32 @entity8 @entity295 @entity7 @entity326 @entity55 @entity1503 @entity520 @entity881 @entity2290
INTRODUCTION: Despite recent advances in the management of @entity326 , mortality rates are still unacceptably high. Early identification of the high-mortality risk group for early intervention remains an issue under exploration. @entity7 ( @entity7 ), soluble @entity7 receptor-1 (sVEGFR1) and @entity2290 have diverse effects in the pathogenesis of @entity295 , which involve @entity32 , anti- @entity32 , endothelial cell repair, and vascular permeability change. Their roles in predicting @entity881 remain to be clarified. METHODS: Pneumonia-related @entity326 @entity1 from medical intensive care units were enrolled for this prospective observational study. We also included 20 @entity1 with @entity55 without @entity881 for comparison. Plasma levels of @entity7 and sVEGFR1 and @entity2290 activity within 24 hours of shock onset were measured. We compared plasma levels of these biomarkers with APACHE II scores between subgroups of @entity1 , and evaluated their predictive value for 28-day @entity881 . RESULTS: A total of 101 @entity1 , including 81 with @entity55 -related @entity326 and 20 with @entity55 without @entity881 , were enrolled. Non-survivors of @entity326 had significantly higher plasma sVEGFR1 levels (659.3    1022.8 vs. 221.1    268.9 pg/mL, respectively, P < 0.001) and @entity2290 activity (47.2    40.6 vs. 27.6    17.2 units, respectively, P = 0.001) when compared with those of the survivors. Kaplan-Meier survival analysis demonstrated significantly higher mortality in @entity1 with higher levels of sVEGFR1 (P < 0.001) and @entity2290 activity (P = 0.031). In Cox regression analysis, plasma sVEGFR1 level was independently associated with, and best predicted, the 28-day mortality of @entity326 (HR: 1.55, 95% CI: 1.05-2.30). Plasma sVEGFR1 level and @entity2290 activity had good correlation with @entity8 , @entity520 , and @entity1503 ; their levels significantly increased when the number of organ dysfunctions increased. In multivariate analysis, plasma sVEGFR1 level (HR: 2.82, 95% CI: 1.17-6.81) and @entity2290 activity (HR: 2.75, 95% CI: 1.06-7.13) were independent predictors of the presence of concomitant multi- @entity881 . The predictive value of @entity7 for @entity881 was limited in @entity55 -related @entity326 @entity1 . CONCLUSIONS: High plasma sVEGFR1 level in the early stage of @entity55 -related @entity326 independently predicted 28-day mortality and multi- @entity881 .
