Effects of chronic binge-like @entity1068 consumption on @entity2072 self-administration in XXXX .

@entity11640 @entity935 @entity167 @entity7875 @entity2072 @entity2608 @entity1068
BACKGROUND: Most @entity2072 abusers also abuse alcohol, but little is known about interactions that promote co-abuse. These experiments in @entity2608 determined the effects of >8 weeks of @entity1068 ( @entity167 ) consumption on @entity2072 self-administration (n=6), effects of @entity935 (DA) receptor antagonists on @entity2072 reinforcement (n=3-4 per drug) and the ability of the D2-like DA receptor agonist @entity11640 to elicit @entity7875 (n=3). METHODS: Monkeys self-administered @entity2072 (0.0-1.0mg/kg/injection, i.v.) under a 300-s fixed-interval schedule and the above-listed variables were measured before @entity167 exposure. Next, monkeys consumed a sweetened, 4% @entity167 solution in the home cage under binge-like conditions: 1h, 5 days/week with daily intake equaling 2.0g/kg @entity167 . After approximately 8 weeks, measures were re-determined, then @entity167 drinking was discontinued. Finally, acute effects of @entity167 on @entity2072 self-administration were determined by infusing @entity167 (0.0-1.0g/kg. i.v.) prior to @entity2072 self-administration sessions (n=4). RESULTS: In five of six monkeys, @entity167 drinking increased self-administration of low @entity2072 doses but did not alter reinforcing effects of higher doses. Self-administration returned to baseline after @entity167 access was terminated (n=3). Effects of DA receptor antagonists on @entity2072 self-administration were not consistently altered after @entity167 consumption, but the ability of @entity11640 to induce @entity7875 was enhanced in two of three monkeys. Acute @entity167 infusions only decreased self-administration of lower @entity2072 doses. CONCLUSIONS: Taken together, the data suggest that long-term @entity167 exposure can increase sensitivity to @entity2072 , possibly by increasing D3 receptor sensitivity. Data do not support a role for acute pharmacological interactions in promoting @entity2072 / @entity167 co-abuse.
