Efficacy of XXXX versus placebo in @entity158 control after hemorrhoidectomy. Results of a controlled clinical trial.

@entity1 @entity868 @entity158 @entity6713 @entity282
INTRODUCTION: @entity6713 occurs in 50% of @entity1 aged > 40 years and is the most common reason for anorectal surgery. @entity158 is the main complication. Multiple topical and systemic drugs have been investigated for @entity158 control, but there is no ideal treatment. @entity868 has been shown to decrease @entity282 but is not used widely. OBJECTIVE: To evaluate the effect of oral @entity868 versus placebo and to assess @entity282 following hemorrhoidectomy. MATERIAL AND METHODS: Controlled clinical trial in adult @entity1 who underwent elective hemorrhoidectomy for grade III/IV @entity6713 . @entity1 were assigned to receive @entity868 (500 mg q8 h orally; study group, SG) or placebo (control group, CG) for 7 days after surgery. @entity158 was assessed using a visual analog scale after surgery. Analgesic administration (time and use of analgesics) and resumption of daily life activities were also assessed. RESULTS: Forty-four @entity1 were included, 22 in each group. @entity282 differed significantly between the SG and CG at 6 h (3.86    0.56, 6.64    1.49), 12 h (5.59    1.33, 8.82    0.79), 24 h (6.86    1.49, 9.73    0.45), day 4 (5.32    2.10, 9.50    0.59), day 7 (3.14    1.03, 7.36    1.39), and day 14 (2.14    0.46, 5.45    1.29). The first analgesia dose was required at 21.27    5.47 h in the CG and 7.09    2.36 h in the SG (p < 0.05), the time of analgesic use was 6.86    1.61 days in the CG and 13.09    2.48 days in the SG (p < 0.05), and resumption of daily activities occurred at 7.59    1.56 days in the CG and 14.73    3.76 days in the SG (p < 0.05). CONCLUSION: Oral administration of @entity868 is effective in @entity158 management after hemorrhoidectomy.
