The relation between two polymorphisms in the @entity4738 gene and body mass index, blood pressure and @entity165 in @entity28 XXXX .

@entity1 @entity16123 @entity4738 @entity28 @entity619 @entity701 @entity165
OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a @entity16123 polymorphism in the @entity4738 ( @entity4738 ) gene is associated with higher sensitivity to low-dose @entity619 (0.25 mg), evaluated as both @entity701 suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the @entity16123 polymorphism, and a BclI restriction site polymorphism in a group of Italian @entity1 with severe @entity28 . DESIGN: Two hundred and seventy-nine @entity1 (mean BMI 45.9 +/- 0.9 kg/m2) were genotyped using both PCR-restriction fragment length polymorphism analysis and Taqman Sequence Detection System. Determination of several metabolic and antropometric parameters was also performed in order to correlate them to the genotype. RESULTS: In this group of @entity28 @entity1 , 13 subjects (eight female, five males) were heterozygous for the @entity16123 variant (allelic frequency 2.3%) and had significantly higher BMI (P < 0.04), resting energy expenditure (P < 0.03) and food intake (P < 0.01) when compared to wild-type homozygotes. When the data were analysed according to sex, female heterozygotes for the @entity16123 allele had significantly higher BMI (P = 0.04), resting energy expenditure (P = 0.03) and food intake (P = 0.008) than @entity28 @entity1 with the wild-type 363 GR gene. Male carriers of this variant also had higher values for these variables although the differences did not reach statistical significance. A case-control study with homozygous wild-type @entity28 subjects which were age-, sex- and BMI-matched, revealed no difference in resting energy expenditure and food intake. The allele frequency of the BclI variant was 27% (89 females and 41 males out of 269 subjects). No differences in anthropometric and metabolic parameters were found between subjects heterozygous or homozygous for this variant @entity4738 in this @entity28 population. However, when we studied the effect of the presence of the BclI polymorphism and the @entity16123 variant in the same individual, we found that the subjects who carried both polymorphisms had a tendency towards higher systolic and diastolic blood pressure and significantly higher total and LDL- @entity165 levels (P = 0.005 and P = 0.05, respectively). DISCUSSION: Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the @entity16123 variant who develop @entity28 , may become even more @entity28 , possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently. Furthermore, these data suggest that @entity16123 carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile.
