Presentation and Progression of Childhood-Onset XXXX in Northern Stockholm County.

@entity1 @entity31 @entity29 @entity1960 @entity30
BACKGROUND: Some studies have suggested that childhood-onset @entity29 ( @entity29 ) is characterized by extensive intestinal involvement and rapid progression to complications. Here, we report the presentation and progression of @entity1 diagnosed with @entity29 during childhood in a population-based cohort from northern Stockholm County. METHODS: Medical records for all 280 @entity1 diagnosed in the period 1990-2007 with childhood-onset @entity29 in northern Stockholm County were followed until 2011 (median follow-up time, 8.8 yr). Disease phenotypes were classified according to the Paris pediatric @entity29 classification. RESULTS: Among the 74 @entity1 with @entity31 , 72% presented with pancolitis. Among the 200 @entity1 with @entity30 ( @entity30 ), 75% presented with @entity1960 . Complicated disease behavior was observed in 18% of @entity1 with @entity30 by end of follow-up. Extension of the disease territory was observed in 22% of @entity1 with @entity31 and 15% of @entity1 with @entity30 . The cumulative risk of intra-abdominal surgery after 10 years was 8% (95% confidence interval, 4%-20%) for @entity31 and 22% (95% confidence interval, 15%-28%) for @entity1 with @entity30 . Nonmucosal healing at 1 year was associated with a complicated disease course in @entity1 with @entity30 (hazard ratio = 14.56; 95% confidence interval, 1.79-118.68; P = 0.01). CONCLUSIONS: @entity1 with childhood-onset @entity29 were characterized by extensive @entity1960 that was relatively stable over time and associated with a relatively low risk of complications and abdominal surgery. Our findings confirm the more extensive disease location in pediatric @entity29 but did not identify the proposed dynamic and aggressive nature of the childhood-onset phenotype. The association of nonmucosal healing with a complicated disease course suggests that endoscopy should guide treatment intensity in childhood-onset @entity30 .
