Production of @entity310 by normal and XXXX .

@entity310 @entity4179 @entity3610 @entity7790
The mechanism of anovulation in @entity3610 remains unknown. As circulating concentrations of FSH are apparently normal, and in vivo, granulosa cells from @entity3610 are hyperresponsive to FSH, it has been suggested that the lack of follicular development in @entity3610 is caused by overexpression of a paracrine growth factor that inhibits steroidogenesis. @entity4179 and the structurally homologous @entity310 ( @entity7790 ) are suitable candidates for this role, but although the production of the latter has been demonstrated in the ovary, no comparison has been performed between the levels in normal ovaries and PCO. We compared the levels of @entity7790 in follicular fluid and in granulosa cell- and theca- and stroma-conditioned media from normal ovaries and PCO. @entity7790 was present in the range of 0.2-200 ng/mL in follicular fluid. There was a significant inverse correlation of @entity7790 with follicle size, with no differences between follicles from normal ovaries and PCO. Granulosa cell-conditioned medium contained concentrations of @entity7790 ranging from 0.1-200 ng/1000 cells. There was a wide range of concentrations in theca- and stroma-conditioned media, with levels varying from 0.2-100 ng/mg tissue and no consistent effect of LH. There were no significant differences between the levels from normal ovaries or PCO in medium conditioned by any compartment of the ovary. We conclude that the failure of folliculogenesis in @entity3610 is not likely to be due to overproduction of @entity7790 by the ovary.
