Expression of Toll-like receptors in nasal epithelium in XXXX .

@entity2023 @entity566 @entity6801 @entity4100 @entity20040 @entity56 @entity11709 @entity13976
UNASSIGNED: Toll-like receptors (TLRs) are important in barrier homeostasis, but their role in airborne @entity566 is not fully understood. The aim was to evaluate baseline and allergen-induced expression of TLR proteins in nasal epithelium during @entity2023 . Nineteen otherwise healthy non-smoking volunteers both @entity56 to birch pollen and non- @entity56 controls were enrolled. We took nasal biopsies before and after off-seasonal intranasal birch pollen or diluent challenge. The expression of epithelial @entity11709 -7, @entity6801 -10, and @entity4100 proteins was immunohistochemically evaluated from the nasal biopsies. The @entity11709 -3 and @entity20040 -10 mRNAs were observed by RNA-microarray. Baseline epithelial expression of TLR proteins was wide and identical in controls and atopics. After off-seasonal intranasal birch pollen challenge, a negative change in the expression score of @entity11709 and @entity13976 proteins was detected in the atopic group. TLR mRNA expression was not affected by birch pollen challenge. Nasal epithelium seems to express all known TLRs. The mechanisms by which @entity11709 , and @entity13976 proteins could affect pollen allergen transport need further studies.
