Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of XXXX risk: a randomized controlled trial.

@entity3978 @entity32 @entity1 @entity28 @entity1674 @entity409 @entity412 @entity65 @entity6398 @entity413
BACKGROUND: Postprandial dysmetabolism-an exaggerated spike in @entity1674 , @entity413 , and insulin-increases @entity65 risk by inducing oxidative stress, @entity32 , and @entity409 . @entity3978 -rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of @entity6398 , but there is little research on their postprandial effects. OBJECTIVE: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (   1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as @entity412 , @entity413 , and insulin responses. DESIGN: Healthy, overweight or @entity28 [mean    SEM body mass index (in kg/m(2)): 31    0.5] adults (mean    SEM age: 28    2 y; 17 @entity1 and 13 @entity1 ) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by >= 1 wk for @entity1 and    1 mo for @entity1 to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. RESULTS: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P < 0.002) and significantly increased @entity1674 , insulin, and @entity413 at all time points (P < 0.001) relative to baseline. CONCLUSIONS: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in @entity1674 , @entity413 , or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other @entity3978 -rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.
