Involvement of the subthalamic nucleus in @entity23 associated with XXXX .

@entity1 @entity23 @entity910 @entity191
Behavioural abnormalities such as @entity23 may develop when @entity1 with @entity191 receive dopaminergic therapy, although they can be controlled by deep brain stimulation of the subthalamic nucleus. We have recorded local field potentials in the subthalamic nucleus of 28 @entity1 with surgically implanted subthalamic electrodes. According to the predominant clinical features of each @entity1 , their @entity191 was associated with @entity23 (n = 10), @entity910 (n = 9) or no dopaminergic mediated motor or behavioural complications (n = 9). Recordings were obtained during the OFF and ON dopaminergic states and the power spectrum of the subthalamic activity as well as the subthalamocortical coherence were analysed using Fourier transform-based techniques. The position of each electrode contact was determined in the postoperative magnetic resonance image to define the topography of the oscillatory activity recorded in each @entity1 . In the OFF state, the three groups of @entity1 had similar oscillatory activity. By contrast, in the ON state, the @entity1 with @entity23 displayed theta-alpha (4-10 Hz) activity (mean peak: 6.71 Hz) that was generated 2-8 mm below the intercommissural line. Similarly, the @entity1 with @entity910 showed theta-alpha activity that peaked at a higher frequency (mean: 8.38 Hz) and was generated 0-2 mm below the intercommissural line. No such activity was detected in @entity1 that displayed no dopaminergic side effects. Cortico-subthalamic coherence was more frequent in the impulsive @entity1 in the 4-7.5 Hz range in scalp electrodes placed on the frontal regions anterior to the primary motor cortex, while in @entity1 with @entity910 it was in the 7.5-10 Hz range in the leads overlying the primary motor and supplementary motor area. Thus, dopaminergic side effects in @entity191 are associated with oscillatory activity in the theta-alpha band, but at different frequencies and with different topography for the motor ( @entity910 ) and behavioural (abnormal impulsivity) manifestations. These findings suggest that the activity recorded in @entity191 @entity1 with @entity23 stems from the associative-limbic area (ventral subthalamic area), which is coherent with premotor frontal cortical activity. Conversely, in @entity1 with l-dopa-induced @entity910 such activity is recorded in the motor area (dorsal subthalamic area) and it is coherent with cortical motor activity. Consequently, the subthalamic nucleus appears to be implicated in the motor and behavioural complications associated with dopaminergic drugs in @entity191 , specifically engaging different anatomo-functional territories.
