Mild decrease in estimated glomerular filtration rate and XXXX are associated with all-cause and cardiovascular mortality in the general population.

@entity1 @entity644 @entity8 @entity1009 @entity1011 @entity2798
BACKGROUND: A recent collaborative meta-analysis by @entity8 : Improving Global Outcomes reported that an estimated glomerular filtration rate (eGFR) <60 mL/ @entity1009 .73 m(2) and an albumin-to-creatinine ratio of >=  10 mg/g were independent predictors for mortality in the general population. However, selection bias, heterogeneity of the cohorts and measurement issues could be limitations. METHODS: We analyzed the relationship of eGFR and @entity644 with mortality in the Korean general population, represented by 112,115 @entity1 , aged >=  20 years, who had a @entity2798 check-up with homogenous calibration of @entity1011 measurement from 2003 to 2009. @entity644 (trace or more) was determined by urine dipstick. RESULTS: eGFR and @entity644 were independently associated with all-cause mortality (ACM) and cardiovascular mortality (CVM), and progressive increases in risks for mortality were noted according to eGFR level and the presence of @entity644 . Compared with eGFR 90-105 mL/ @entity1009 .73 m(2), hazard ratio (HRs) for ACM were 1.60 [95% confidence interval (CI) 1.12-2.30] for eGFR 60-74 mL/ @entity1009 .73 m(2) and 3.54 (2.20-5.68) for eGFR <60 mL/ @entity1009 .73 m(2) in @entity1 with no @entity644 . In @entity1 with @entity644 , HRs for ACM were 2.10 (1.41-3.12) for eGFR 75-89 mL/ @entity1009 .73 m(2), 2.30 (1.50-3.53) for eGFR 60-74 mL/ @entity1009 .73 m(2) and 3.77 (2.15-6.38) for eGFR <60 mL/ @entity1009 .73 m(2). Similar findings were observed for CVM. CONCLUSIONS: eGFR <75 mL/ @entity1009 .73 m(2) and urine dipstick trace or more were independent risk factors of ACM and CVM. The risks of adverse outcomes are greater in the general population with mild @entity8 or mild @entity644 .
