Quantification of regulatory T cells in @entity1 with XXXX .

@entity1 @entity404 @entity1252 @entity2902 @entity688 @entity792 @entity7986
@entity404 + T cells that constitutively express @entity2902 exhibit powerful suppressive properties. Such cells have been denominated regulatory T cells (T(R)). Alterations in T(R)cells are known to cause organ-specific @entity792 in animal models. The aim of this work was to quantify @entity404 + @entity2902 + T cells in @entity1 with @entity1252 ( @entity1252 ). Thirty untreated @entity1 (ten with active disease) and ten healthy volunteers were studied. Flow cytometry was used to quantify cell populations. @entity404 + @entity7986 +, @entity404 + @entity2902 + and @entity404 + @entity2902 (bright) cells were considered. Peripheral blood mononuclear cell cultures were performed and supernatants collected for @entity688 and 12 measurement. @entity404 + @entity2902 + cells were significantly decreased in @entity1 with active disease when compared to control subjects and @entity1 without disease activity (P<0.001). @entity404 + @entity7986 + cells were increased in @entity1 with active disease when compared to controls (P=0.041). Accordingly, @entity404 + @entity2902 (bright) cells were decreased in @entity1 with active disease compared to healthy subjects (P<0.001). IL-12 production was hampered in cells from @entity1 during periods of active disease when compared to healthy controls and @entity1 during remission (P<0.001). We observed a correlation between decreased T(R)number and reduced IL-12 mononuclear cell production (r=0.362, P=0.05). This work demonstrates that @entity404 + @entity2902 + T cells are decreased in @entity1 with clinically active @entity1252 .
