@entity6019 and poorly differentiated XXXX .

@entity1 @entity242 @entity6020 @entity5 @entity6019 @entity3905 @entity1478
U.T.M.D. Anderson Hospital cases filed as @entity1478 were reviewed. Malignant mixed @entity5 , @entity6020 , and poorly differentiated @entity242 of uncertain origin were excluded, and a minimum of 36 months follow-up was required. On pathologic examination, the remaining cases fell into two distinct groups: @entity6019 (11 cases) and poorly differentiated @entity1478 (seven cases). The former were characterized histologically by small to medium-sized uniform cells and distinctive arterial vasculature resembling the spiral arteries to the normal endometrium; they were thus considered to exhibit endometrial stromal differentiation. The latter showed topographic configurations indicative of endometrial origin but did not demonstrate endometrial stromal differentiation; they were composed of generally larger cells with nuclear hyperchromatism and pleomorphism and had no distinctive vascular pattern. The mitotic rate was usually low in @entity6019 and high in poorly differentiated @entity1478 , although two examples of the former had more than 20 mitoses per 10 high-power fields. All but one of the @entity1 with @entity6019 were less than 50 years of age, whereas all of those with poorly differentiated @entity1478 were older than 50 years. One @entity1 with @entity6019 died of @entity5 , two were living with @entity5 at latest follow-up, and eight were clinically @entity5 -free. By contrast, six of those with poorly differentiated @entity1478 died of @entity5 , all within 34 months. The extent of @entity5 was the major prognostic factor in both groups; the three @entity1 with @entity6019 who were dead or living with @entity5 all had extrauterine extension at the time of hysterectomy (only one of the other eight did so) and all six who died with poorly differentiated @entity1478 had myometrial invasion (the one survivor had a @entity5 limited to the endometrium). Other pathologic factors, including mitotic rate, had no prognostic significance in either category; of particular interest was that both @entity1 who had @entity6019 with high mitotic rates were @entity5 -free. It is concluded that @entity6019 is a distinct @entity5 entity whose diagnosis should not depend on mitotic rate, and it is suggested that poorly differentiated @entity1478 is closely related to @entity3905 , in view of clinical and pathologic similarities.
