The relationship between XXXX and hemodialysis-related connective tissue disorders.

@entity1 @entity23032 @entity2783 @entity2262 @entity5145 @entity923 @entity461 @entity454
Dialysis-related @entity2783 (DRA), such as @entity5145 ( @entity5145 ) and @entity923 ( @entity923 ), occurs in the connective tissues of @entity1 on long-term hemodialysis (HD). Recently, it was suggested that advanced glycation end products (AGEs) and @entity2262 ( @entity2262 ) modified with AGEs are related to DRA. The aim of this study is to elucidate whether serum levels of @entity23032 , which is an AGE, relate to the occurrence of DRA in @entity1 with long-term HD. 127 @entity454 @entity1 , with @entity5145 or @entity923 and undergoing HD, were examined. Serum @entity23032 was measured by the HPLC method with column switching. @entity2262 and intact parathyroid hormone (i- @entity461 ) were measured. @entity23032 levels were significantly elevated in the @entity5145 , @entity923 , and DRA groups ( @entity1 in the DRA group had either @entity5145 and/or @entity923 ). There were no significant differences in the @entity2262 and i- @entity461 levels between any group. The duration of HD did not correlate with either @entity23032 or @entity2262 levels, but did with i- @entity461 . Receiver-operating characteristic (ROC) analysis was performed to examine the discriminatory ability of @entity23032 , @entity2262 , and i- @entity461 for DRA. The area under the ROC curve was the greatest for @entity23032 . Serum @entity2262 levels were not related with the occurrence of DRA. The fact that serum @entity23032 was higher in DRA than in non-DRA indicates that it has potential as an indicator of the occurrence of DRA in long-term HD @entity1 .
