[mRNA expressions of MAGE genes in human XXXX ].

@entity5 @entity20521 @entity2 @entity957 @entity3 @entity420
BACKGROUND: To investigate the expressions of @entity20521 in @entity2 at mRNA level. METHODS: Using a reverse transcription-polymerase chain reaction assay (RT-PCR), the expressions of @entity20521 in 35 @entity2 samples and non-tumorous lung tissues were examined. RESULTS: Of the 35 @entity5 samples, the @entity20521 were expressed at mRNA level in 22.9% (8/35), 62.9% (22/35), 37.1% (13/35) and 77.1% (27/35) respectively. At least one of these genes was expressed in 85.7% (30/35) of the samples. Two or more of these genes were expressed in 71.4% (25/35) of the samples. None of the non-tumorous lung tissue was positive for these genes. No significant difference of the frequency of MAGE gene expression was found between @entity420 and @entity957 , between different @entity5 stages, and between groups with or without lymph node @entity3 (P > 0.05). CONCLUSIONS: @entity20521 are expressed at a high percentage in @entity2 . All of these genes are negative in the adjacent non tumorous lung tissue. These results indicate the possibility of a future specific immunotherapy for @entity2 based on these MAGE antigens.
