Drug-induced pneumonitis: thin-section CT findings in 60 XXXX .

@entity1 @entity55 @entity26 @entity3174 @entity9992
PURPOSE: To describe thin-section computed tomographic (CT) findings in @entity1 with drug-induced @entity55 , to compare these CT findings, and to correlate them with arterial @entity26 tension level. MATERIALS AND METHODS: Thin-section CT scans obtained in 60 @entity1 with drug-induced @entity55 were evaluated retrospectively. The @entity1 had 31 cases of antineoplastic agent-induced @entity55 and 29 cases of nonneoplastic agent-induced @entity55 (antibiotic agent, 20 cases; herbal medicine [sho-saiko-to], four cases; antirheumatic agent, three cases; @entity3174 , one case; @entity9992 , one case). CT scans were reviewed by two chest radiologists in consensus. Correlation between arterial @entity26 tension level and the extent of disease at CT was available in 21 @entity1 . These two factors were compared by using the Spearman rank correlation coefficient. RESULTS: The predominant findings in antineoplastic agent-induced @entity55 were diffuse or multifocal ground-glass opacities with intralobular interstitial thickening. The predominant CT findings in antibiotic agent-induced @entity55 were patchy ground-glass opacities with centrilobular opacities and interlobular septal lines. The predominant CT findings in herbal medicine-induced @entity55 were diffuse ground-glass opacities with patchy consolidation. Interlobular septal lines and centrilobular opacities were observed more frequently in antibiotic agent-induced @entity55 , and intralobular interstitial thickening was observed more frequently in antineoplastic agent-induced @entity55 . A significant correlation was established between arterial @entity26 tension level and extent of disease at CT (r = -0.84, P <.05). CONCLUSION: In addition to ground-glass opacities and interlobular septal lines, the most common thin-section CT findings were intralobular interstitial thickening, observed in antineoplastic agent-induced @entity55 , and centrilobular opacities, observed in antibiotic-induced @entity55 .
