The effect of dose intensity on M-VAC therapy for advanced XXXX .

@entity632 @entity1 @entity137 @entity1261 @entity5 @entity900 @entity64132 @entity236 @entity1499 @entity5713
M-VAC therapy ( @entity1499 , @entity5713 , @entity632 , and @entity900 ) has improved the treatment results of @entity5 @entity1 . However, it is sometimes complicated by @entity137 , including @entity236 . We analyzed the relative dose intensity in each @entity1 undergoing M-VAC chemotherapy in relation to the chemotherapeutic effect and survival. In addition, the role of @entity1261 ( @entity1261 ) in the dose intensity of M-VAC therapy was analyzed. Between June 1988 and March 1993, 29 @entity1 with advanced @entity5 were treated with M-VAC therapy in our institution. Of 18 @entity1 with evaluable lesions, 2 (11.1%) showed a @entity64132 (38.9%) showed a partial response (PR), and the overall response rate was 50.0%. The median follow-up period for these 18 @entity1 was 14.6 months and the median survival was 8.7 months, with 12 of the 18 @entity1 being alive at the time of analysis. The relative dose intensity (RDI) for these 18 @entity1 was 0.81 for @entity1499 , 0.80 for @entity5713 , 0.92 for @entity632 , and 0.91 for @entity900 , for a mean RDI of 0.87. There was no correlation between the chemotherapeutic effect and the RDI. When we calculated the RDI for all 29 @entity1 who underwent M-VAC therapy, @entity1261 increased the RDI of @entity632 significantly. The results of this retrospective study indicate that a dose intensity for M-VAC therapy in the range of 0.61-1.00 is unlikely to correlate with the chemotherapeutic effect, although @entity1261 contributes to increasing the RDI of @entity632 .
