Rectal biopsies obtained with jumbo biopsy forceps in the evaluation of XXXX .

@entity1 @entity1963
BACKGROUND AND AIM: Refractory constipation is an extremely common problem in @entity1 and @entity1 . The diagnostic suspicion of @entity1963 often arises in this clinical setting. Diagnosing @entity1963 can be difficult; however, excluding the diagnosis is much easier, only requiring the demonstration of ganglion cells in the distal rectum. The most common method for obtaining tissue from the rectum involves a blind suction biopsy. This technique has been complicated by serious adverse events, equipment malfunction, and inadequate specimens. Our goal was to evaluate the adequacy of specimens obtained with a flexible endoscope and jumbo biopsy forceps to rule out @entity1963 in the @entity1 outside the newborn period. @entity1 AND METHODS: We retrospectively reviewed 668 rectal biopsies taken during 167 endoscopies on 156 @entity1 being evaluated for @entity1963 from 2001 to 2008 at the Baystate Medical Center @entity1 's Hospital. Four biopsies were taken from each @entity1 approximately 2.5 cm from the anal verge. Biopsies were obtained using a flexible endoscope and jumbo biopsy forceps. During the first 6 years the Olympus FB-50U-1 large cup fenestrated biopsy forceps was used. During the last 2 years the Boston Scientific Radial Jaw 4 Jumbo biopsy forceps was used instead. RESULTS: The Boston Scientific Radial Jaw 4 Jumbo biopsy forceps yielded adequate specimens 93% of the time, which surpassed most published results of other techniques. There were no complications reported. CONCLUSIONS: Obtaining rectal biopsies with a flexible endoscope and jumbo biopsy forceps is a safe and effective means to rule out the diagnosis of @entity1963 in @entity1 .
