World Health Organization grade III XXXX . A retrospective study for outcome and prognostic factors assessment.

@entity5 @entity1 @entity1653
BACKGROUND: @entity1653 are uncommon primary @entity5 associated with high level of recurrence and low life expectancy. Through three institutions experience, we analysed the clinical characteristics of @entity1 with @entity5 to determine their outcome and identify prognostic factors that may influence recurrence and survival. MATERIAL AND METHODS: A retrospective search identified 62 cases of WHO grade III @entity1653 , of whom 9 (14.5%) were not considered in the survival analysis as no follow-up data were available. Thirty @entity1 (48.4%) had a previous history of non- @entity5 surgery. The @entity1 underwent a total of 139 surgical resections and 42 courses of radiotherapy of which 27 were given after the WHO grade @entity1653 diagnosis. RESULTS: Eighteen @entity1 (29.5%) were re-operated for a relapse of their @entity1653 . Median time between the first and the second surgery was 1.3 years. Median overall survival time was 3.5 years. Overall survival probabilities at 1, 2 and 5 years were 74.6%, 95% confidence interval (CI) [63.8, 87.1], 58.7%, 95% CI [46.4, 74.3] and 37.7%, 95% CI [25, 56.8], respectively. Extent of resection was associated with the survival. DISCUSSION: This retrospective series highlights the poor prognosis associated with the diagnosis of @entity5 . Complete or subtotal resection may prolong the @entity1 ' survival. We could not confirm the usefulness of postoperative radiotherapy.
