[Ecchymotic patches of the fingers and XXXX ].

@entity1 @entity55567 @entity44759 @entity2100 @entity74 @entity158 @entity750 @entity460
Ecchymotic patches on the fingers and @entity44759 in @entity55567 are two benign but recurrent clinical disorders occurring chiefly in young @entity1 . They involve superficial cutaneous hemorrhagic signs. Both disorders testify to @entity2100 without perturbation of general hemostasis. Diagnosis is easy for those familiar with the disorders. Ecchymotic episodes accompanied by @entity158 begin at the roots of the fingers. Microtraumatism is soon seen to be involved. Ecchymosis develops at the flexor muscles of the fingers but "capillary" resistance is only reduced in one third of cases. The pathogenic explanation involves rupture of a small post-capillary vein due to disorders in the control system of kinins and local metabolites. The autoerythrocyte sensitization syndrome described in 1955 by Gardner and Diamond is characterized by painful and febrile episodes followed by purpuric and ecchymotic lesions of the skin on various parts of the body, but not necessarily on the legs. Dysneurotonic effects are frequent but diagnosis is based upon promotion of the disorder by intradermal or subcutaneous injection of a minimal quantity of autologous blood. Immunological effects are considered but the ailment involves @entity74 , notably of the capillary-vein segment, in particular at Copley's endo-endothelial fibrin film. Imbalance in fibrin formation and lysis is associated with perturbation of the kinin and @entity750 systems. In addition to the use of certain bioflavonoids and @entity460 inhibitors, prevention and treatment should involve consideration of drugs which affect plasticity in the vascular wall and pericapillary interstitial conjunctiva and the rheological properties of blood flow and interstitial tissue.
