Epidemiology of XXXX .

@entity5 @entity157 @entity1 @entity96
Because of its high incidence in many of the most populous countries in the world, its often fulminant course, poor response to conservative treatment, low resectabilty rate when symptomatic, high recurrence rate after resection and liver transplantation, and grave prognosis, @entity157 is now regarded as one of the major @entity5 . @entity157 is the most common primary @entity96 . Relative to other @entity5 , it ranks fifth in overall frequency (fifth in @entity1 and eighth in @entity1 ) and fourth in annual mortality rate. An estimated 372,000 new cases of @entity157 are diagnosed each year, constituting 4.6% of all new @entity1 @entity5 (6.3% in @entity1 ; 2.7% in @entity1 ). The annual mortality rate from the @entity5 is virtually the same as its annual incidence. The highest incidences occur in eastern and southeastern Asia, some of the Western Pacific islands, and sub-Saharan Africa. Intermediate incidences are found in eastern and southern Europe, the Caribbean, Central America, and Western Asia. @entity157 is uncommon in the remaining countries. @entity1 are affected more often than are @entity1 . The incidence generally increases with increasing age, although there is a definite shift towards a younger age distribution in black African and ethnic Chinese populations.
