DWI Lesion Patterns Predict Outcome in Stroke XXXX with Thrombolysis.

@entity1 @entity2500 @entity1188 @entity432 @entity385
BACKGROUND: Lesion patterns may predict prognosis after acute @entity385 within the middle cerebral artery (MCA) territory; yet it remains unclear whether such imaging prognostic factors are related to @entity1 outcome after intravenous thrombolysis. AIMS: The aim of this study is to investigate the clinical outcome after intravenous thrombolysis in acute MCA @entity385 with respect to diffusion-weighted imaging (DWI) lesion patterns. METHODS: Consecutive acute @entity385 cases of the MCA territory treated over a 7-year period were retrospectively analyzed. All acute @entity2500 @entity1 underwent a MRI scan before intravenous thrombolytic therapy was included. DWI lesions were divided into 6 patterns (territorial, other cortical, small superficial, internal border zone, small deep, and other @entity1188 ). Lesion volumes were measured by dedicated imaging processing software. Favorable outcome was defined as modified Rankin scale (mRS) of 0-2 at 90 days. RESULTS: Among the 172 @entity1 included in our study, 75 (43.6%) were observed to have territorial @entity1188 patterns or other deep @entity1188 patterns. These @entity1 also had higher baseline NIHSS score (p < 0.001), a higher proportion of large cerebral @entity432 (p < 0.001) and larger @entity1188 volume (p < 0.001). Favorable outcome (mRS 0-2) was achieved in 89 @entity1 (51.7%). After multivariable analysis, groups with specific lesion patterns, including territorial @entity1188 and other deep @entity1188 pattern, were independently associated with favorable outcome (OR 0.40; 95% CI 0.16-0.99; p = 0.047). CONCLUSIONS: Specific lesion patterns predict differential outcome after intravenous thrombolysis therapy in acute @entity2500 @entity1 .
