@entity12023 effects on pupil size and pupillary light reflexes in XXXX .

@entity1 @entity303 @entity191 @entity195 @entity12023 @entity8124
Diagnostic tests for @entity195 ( @entity195 ) involving @entity12023 blockade of cholinergic oculomotor functions were examined in @entity195 @entity1 (n=15), @entity191 ( @entity191 ) @entity1 (n=15), and non-clinical control (NC) @entity1 (n=15). Pupillographic methods were used to measure pupil diameter and pupillary light reflexes after double-blind ocular administration of dilute @entity12023 (0.01%) in one eye and saline in the other eye. Changes in pupil size were measured in bright background light and near-darkness. @entity12023 increased pupil diameter to a similar extent in all three groups in light and darkness. @entity12023 also reduced the amplitude and latency of the pupillary light reflex to a similar extent for all three groups. @entity12023 pupillary response tests, therefore, were not sensitive or specific diagnostic tests for @entity195 . Peak constriction amplitude of the pupillary light reflex was significantly reduced in both eyes in @entity195 and @entity191 groups relative to non-clinical controls, but @entity195 and @entity191 groups did not differ significantly. The pupillary light reflex test, therefore, was sensitive to @entity195 , but lacked adequate specificity. Finally, peak constriction amplitude correlated significantly with @entity303 severity and @entity8124 treatment may have partially normalized pupillary light reflex abnormalities in @entity195 @entity1 . The pupillary light reflex test, therefore, may index central cholinergic dysfunction associated with disease progression and improvement in cholinergic function associated with pharmacologic treatment response in @entity195 .
