Whole exome sequencing reveals recurrent mutations in @entity2674 and FAT genes in XXXX of the pancreas.

@entity1 @entity68493 @entity1124 @entity5 @entity70215 @entity2674 @entity900 @entity3981 @entity189 @entity23138 @entity3
@entity3981 is a rare @entity5 with a poor prognosis. Compared to @entity1124 , its molecular features are poorly known. We studied a total of 11 @entity3981 , including 3 by exome and 4 by target sequencing. Exome sequencing revealed 65 nonsynonymous mutations and 22 indels with a mutation rate of 3.4 mutations/Mb per @entity5 , on average. By accounting for not only somatic but also germline mutations with loss of the wild-type allele, we identified recurrent mutations of @entity2674 and FAT genes. @entity2674 showed somatic or germline premature termination mutations, with loss of the wild-type allele in 3 of 7 @entity5 . @entity23138 , @entity68493 , and @entity70215 showed somatic or germline missense mutations in 4 of 7 @entity5 . The germline FAT mutations were with loss of the wild-type allele. Loss of @entity2674 expression was observed in 5 of 11 @entity5 . One @entity1 with a @entity2674 -mutated @entity5 experienced complete remission of liver @entity3 following @entity900 chemotherapy. In conclusion, @entity3981 show a distinct mutation pattern and often harbor somatic or germline mutations of @entity2674 and FAT genes. This result may warrant assessment of @entity2674 abrogation in @entity1 with the @entity189 to determine their sensitivity to chemotherapy.
