XXXX exposures reported to US poison centers 2000-2014: Temporal trends and outcomes.

@entity1 @entity560
UNASSIGNED: There has been an increased use of @entity560 both by prescription and by the public as a widely available supplement. We evaluated 15 years of single-substance @entity560 exposures to US poison centers. METHODS: Retrospective analysis of data from the National Poison Data System (NPDS) to evaluate clinical effects, trends, and outcomes of exposures to @entity560 over the period January 1, 2000 through June 30, 2014. Cases were limited to exposures involving @entity560 as a single substance. Multiple vitamin products that may have included @entity560 were not included in this study. RESULTS: From 2000 through June 30, 2014, there were 25,397 @entity1 exposures to @entity560 reported to NPDS. There was a mean of 196 cases per year from 2000 to 2005, followed by a 1600% increase in exposures between 2005 and 2011 to a new annual mean of 4535 exposures per year. The mean and median ages were 23.4 years and 10 years, respectively. There were no fatalities, but five (0.02%) major effect outcomes. Serious medical outcomes (major or moderate outcome) were infrequent, ranging from 2 @entity1 /year to 22 @entity1 /year. Clinical effects were primarily gastrointestinal (0.7-1.5%) and mild neurological effects (0.2-0.4%). There was a decline in the percentage of @entity1 treated in a health care facility and of @entity1 with serious medical outcome. CONCLUSION: Despite the enormous increase in number of exposures, there was not a significant increase in @entity1 with a serious medical outcome. Rare severe outcomes may occur.
