Evaluation of XXXX management by total skin electron beam therapy with "translational technique".

@entity4888 @entity1 @entity137 @entity8721 @entity66 @entity5 @entity1066 @entity194 @entity272
PURPOSE: The aim of this study was to evaluate the outcomes of total skin electron beam therapy (TSEBT) with "translational technique" in the management of @entity4888 ( @entity4888 ). METHODS: Between January 1995 and October 2014, 51 @entity1 with @entity4888 were treated using TSEBT with translational technique. The total dose was 2800-3600 cGy, de-livered in 7 to 20 fractions. Out of the total 51 @entity1 , 22 (43.1%) had T2 (generalized patch/plaque) disease, 20 (39.3%) had T3 disease ( @entity5 stage), and 9 (17.6%) had @entity66 . Radiation-related late @entity272 parameters including @entity194 , pigmentation changes, hair loss, @entity8721 and @entity1066 were assessed according to RTOG/EORTC Late Radiation Morbidity Scoring Schema after at least 3 months from TSEBT. RESULTS: Treatment response was categorized as complete remission (CR), partial remission (PR), or non-responding (NR) lesions. After TSEBT with translational technique, CR rate was 68.6% and PR rate 23.5%, while the NR rate was 7.9%. Overall, the rates of grade 1, grade 2, grade 3, and grade 4 @entity137 were 17.6% )9 @entity1 ), 39.3% (20 @entity1 ), 35.3% (18 @entity1 ), and 7.8% (4 @entity1 ), respectively. At a median follow-up of 79 months (range 14-142), overall survival (OS) and disease-free survival (DFS) rates were 83% and 46%, respectively. CONCLUSION: For @entity1 with @entity4888 refractory to topical chemotherapy and phototherapy, TSEBT with translational technique offers excellent local control (LC: CR+PR) and favorable OS rates along with substantial relief of symptoms.
