Striational autoantibodies: quantitative detection by enzyme immunoassay in @entity1737 , XXXX , and recipients of @entity2361 or allogeneic bone marrow.

@entity1 @entity704 @entity5 @entity1737 @entity2361 @entity2132
Striational autoantibodies (StrAb) are a useful serologic marker of @entity704 in @entity1 with @entity1737 ( @entity1737 ). We compared a standard immunofluorescence method with a new enzyme immunoassay (EIA) for detection of StrAb. Retrospective testing of 264 stored sera by the two methods yielded well-correlated results (58 sera were positive by both assays; r = 0.8). For 104 @entity1 with spontaneously acquired @entity1737 or @entity704 , results were 100% concordant, of which 53% were positive. For 34 recipients of @entity2361 , StrAb were found in 15% by EIA and in 6% by immunofluorescence. StrAb were detected in two of four bone marrow recipients by EIA and in one by immunofluorescence. Prospective testing of 434 fresh sera (of which 49 were positive by the two methods) yielded discordant results in only 4. Serial EIA quantitation of StrAb in two @entity1 with @entity1737 and @entity704 proved useful in monitoring immunosuppressant therapy and in a third @entity1 predicted recurrence of the @entity5 . A high prevalence of StrAb was detected by both assays in elderly @entity1 with spontaneous @entity1737 , but StrAb were more readily quantifiable by EIA. The EIA method proved to be highly sensitive and specific for detecting StrAb in @entity1 with @entity704 with and without @entity1737 , in @entity1 treated with @entity2361 , and in those with @entity2132 after bone marrow transplantation.
