The effects of @entity40424 exposure on brain catecholamines in XXXX .

@entity71280 @entity2515 @entity935 @entity19231 @entity40424 @entity8584 @entity35 @entity669 @entity1063
1. @entity35 exposed to 2.0 mg/1. @entity40424 ( @entity40424 ) in the inspired air for 2 days, 4 h a day, showed a 13% decrease in their brain @entity1063 concentration and a 16% increase in their brain @entity935 concentration.2. After exposure for 5 or 10 days there was a further decrease in the concentration of @entity1063 in the brain, but brain @entity935 returned to the control level.3. In animals treated intraperitoneally with 2.0 mg/kg @entity2515 and exposed 2 and 3 days later to 2.0 mg/1. CS(2) for 4 h per day, the brain @entity935 concentration showed a 77% increase compared with the unexposed reserpinized animals, but the @entity1063 concentration remained unchanged.4. The @entity935 concentrations in the adrenals after 10 days' exposure to 2.0 mg/1. CS(2) were 67% to 100% higher than in the control animals. In reserpinized @entity35 , 2 days' exposure to @entity40424 nearly trebled the @entity935 content of adrenals.5. Exposure to @entity40424 had no effect on the @entity669 concentration in the brain, and there was no change in the brain @entity19231 ( @entity19231 ) activity. @entity669 in the brain showed a 30 to 96% increase in concentration and @entity19231 activity, using @entity71280 as substrate, showed an approximately 5% increase 0.5 to 2 h after the subcutaneous administration of 500 mg/kg @entity8584 .6. CS(2) at 10(-2)M or lower concentrations had no inhibitory effect on the brain @entity19231 activity in vitro. @entity8584 inhibited @entity19231 at 10(-2)M, but not at 10(-3)M or lower concentrations.
