Using saccades to diagnose covert hepatic XXXX .

@entity1 @entity410 @entity82 @entity75 @entity73 @entity99
UNASSIGNED: @entity99 ( @entity99 ), previously known as Minimal @entity99 , is a subtle @entity73 found in 30-70  % of @entity82 @entity1 . It has been linked to poor quality of life, @entity410 to drive, and increased mortality: treatment is possible. Despite its clinical significance, diagnosis relies on psychometric tests that have proved unsuitable for use in a clinical setting. We investigated whether measurement of saccadic latency distributions might be a viable alternative. We collected data on 35 @entity82 @entity1 at Addenbrooke's Hospital, Cambridge, with no evidence of clinically overt @entity75 , and 36 age-matched healthy controls. Performance on standard psychometric tests was evaluated to determine those @entity1 with @entity99 as defined by the World Congress of Gastroenterology. We then compared visually-evoked saccades between those with @entity99 and those without, as well as reviewing blood test results and correlating saccadic latencies with biochemical parameters and prognostic scores. @entity82 @entity1 have significantly longer median saccadic latencies than healthy controls. Those with @entity99 had significantly prolonged saccadic latencies when compared with those without @entity99 . Analysis of a @entity82 @entity1 's saccades can diagnose @entity99 with a sensitivity of 75  % and a specificity of 75  %. We concluded that analysis of a @entity82 @entity1 's saccadic latency distributions is a fast and objective measure that can be used as a diagnostic tool for @entity99 . This improved early diagnosis could direct avoidance of high-risk activities such as driving, and better inform treatment strategies.
