Risk factors for the rapid increase in risk of acute coronary events in XXXX with new-onset @entity309 : a nested case-control study.

@entity1 @entity1187 @entity65 @entity7134 @entity583 @entity309
OBJECTIVE: To investigate risk factors for @entity1187 ( @entity1187 ) in @entity1 with new-onset @entity309 ( @entity309 ). METHODS: We performed a nested case-control study of @entity1 with incident @entity309 included in the Epidemiological Investigation of @entity309 study. Cases with @entity1187 were identified using Swedish national health registers and matched with up to 5 controls without @entity1187 , based on incidence density-based sampling. Information on potential exposures (clinical disease activity, serologic features, genetic markers, comorbidities, pharmacotherapies, and sick leave) was collected from medical charts and register-based sources. RESULTS: We identified 138 cases and 624 controls. Smoking, history of @entity583 , and >50 days of sick leave the year following @entity309 onset were associated with an increased risk of @entity1187 . Area under the curve measurements of C-reactive protein level, erythrocyte sedimentation rate, Disease Activity Score in 28 joints (DAS28), and global health in the upper tertile during the first year and the complete followup period were both strongly associated with an increased risk of @entity1187 . Treatment with disease-modifying antirheumatic drugs did not alter the @entity1187 risk, nor did the presence of rheumatoid factor (RF) or shared epitope alleles, whereas high anti-citrullinated protein antibody ( @entity7134 ) levels were borderline significantly associated with @entity1187 risk. CONCLUSION: In this study of risk factors for @entity1187 in incident @entity309 , clinical markers of inflammatory activity, disease activity, and total number of days of sick leave and disability pension during the first year following @entity309 onset were identified as @entity1187 risk factors. We found no association with RF, which was previously linked to @entity65 risk in @entity309 , but there was a borderline significant association with high @entity7134 levels.
