The pro-inflammatory role of XXXX at the maternal-fetal interface.

@entity66 @entity1356 @entity11707 @entity1254 @entity1468 @entity56932 @entity687
PROBLEM: A successful pregnancy is contingent on maternal tolerance of the immunologically foreign fetus. @entity66 such as @entity1468 arise in part due to an inappropriate immune response by the placenta. A number of molecules have been proposed to temper cellular response to pro-inflammatory mediators, including @entity11707 and @entity56932 . METHODS: Cytotrophoblast cells from healthy term placentas were treated with @entity1254 in vitro and analyzed with qPCR and ELISA-based assays. Immunohistochemistry was performed on term villous sections and cultured trophoblasts. RESULTS: Treatment with @entity1254 increased expression of @entity1356 and @entity687 . Term villi express @entity11707 in cytotrophoblasts and the syncytiotrophoblast, and @entity56932 by the syncytiotrophoblast. Treatment of trophoblast cells with @entity1254 increased @entity56932 expression. CONCLUSION: These data describe a role for @entity1254 in enhancing pro-inflammatory signals in in vitro syncytialized trophoblasts. Additionally, this represents the first time the @entity11707 / @entity56932 pathway has been implicated in a trophoblast response to a pro-inflammatory mediator.
