Prognostic Factors in XXXX Less Than 3 Centimeters: Actuarial Analysis, Accumulative Incidence and Risk Groups.

@entity1 @entity5 @entity1149 @entity1350 @entity204
INTRODUCTION: In TNM classification, factors determining the @entity5 ( @entity5 ) component in @entity1149 have scarcely changed over time and are still based solely on anatomical features. Our objective was to study the influence of these and other morphopathological factors on survival. METHODS: A total of 263 @entity1 undergoing lung resection due to stage I @entity1149  <=3cm in diameter were studied. A survival analysis and competing-risk estimate study was made on the basis of clinical, surgical and pathological variables using actuarial analysis and accumulative incidence methods, respectively. A risk model was then generated from the results. RESULTS: Survival at 5 and 10 years was 79.8 and 74.3%, respectively. The best prognostic factors were presence of symptoms, smoking habit and FEV1>60%, number of resected nodes>7, squamous histology, @entity1350 , absence of visceral pleural invasion and presence of invasion more proximal than the lobar bronchus. All these were statistically significant according to the actuarial method. The factor "age<50 years" was close to the margin of statistical significance. Pleural invasion and vascular invasion were entered in the multivariate analysis. The competing-risk analysis showed a probability of @entity204 due to @entity5 of 14.3 and 35.1% at 5 and 10 years, respectively. Significant variables in the univariate and multivariate analyses were similar, with the exception of FEV1>60%. CONCLUSIONS: Pleural invasion and vascular invasion determine survival or risk of @entity204 due to @entity1149  <=3cm and can be used for generating a predictive risk model.
