Entry of XXXX cells into islets induces changes that lead to amplification of the cellular response.

@entity4725 @entity379 @entity1619 @entity2071
In an accompanying paper, we find specific localization of @entity1619 cells only to islets of Langerhans bearing the specific antigen. Instrumental in the specific localization was the presence of intraislet dendritic cells bearing the b-cell-peptide-MHC complex. Here, we report that the entry of diabetogenic CD4 T cells very rapidly triggered inflammatory gene expression changes in islets and vessels by up-regulating chemokines and adhesion molecules. @entity4725 ( @entity4725 ) expression was notable in blood vessels, as was @entity2071 ( @entity2071 ). @entity2071 was also found on b-cells. These expression changes induced the entry of nonspecific T cells that otherwise did not localize to the islets. In contrast to the entry of diabetogenic CD4 T cells, the entrance of nonspecific T cells required a chemokine response and @entity4725 expression by the islets. @entity379 was important for the early gene expression changes in the islets. By microarray analysis, we detected up-regulation of a group of IFN-inducible genes as early as 8 h post-T-cell transfer. These studies establish that entry of @entity1619 cells induces a state of receptivity of islets to subsequent immunological insults.
