Distribution of a new B-cell-associated surface antigen (BL7) detected by a monoclonal antibody in human XXXX .

@entity981 @entity19 @entity5 @entity1072 @entity3052 @entity1582 @entity1892 @entity1778 @entity9865 @entity236 @entity1860
A murine monoclonal antibody (anti-BL7) was raised by immunization of BALB/c @entity19 with a precursor B-cell line (Josh-7) which detects a heat-stable, nonimmunoprecipitable antigen. The expression of BL7 was investigated in peripheral blood and/or @entity236 cell suspensions stained by indirect immunofluorescence and analyzed by flow cytometry. Lymphoblasts from 43 of 43 cases of "null" @entity981 were BL7-. Five cases of @entity981 and 5 cases of @entity1860 were also BL7-. All 63 cases of @entity1072 were BL7+. Neoplastic cells in 22 of 28 cases of @entity1892 in @entity1778 phase were also BL7+. Expression of BL7 showed some correlation with Rappaport's histological classification. Four cases of @entity1582 and @entity9865 were BL7-. Twenty-three cases of @entity3052 were also analyzed. Of these, only the acute promyelocytic (M3,4 cases) and acute myelomonocytic (M4, one case) varieties expressed BL7 on a small proportion (approximately 15%) of the @entity1778 cells. All other subgroups were BL7-. The reactivity of anti-BL7 was compared to other B-cell antibodies on selected samples and was shown to be different from B1, B2, and the BA antibodies. Anti-BL7 is a unique monoclonal antibody useful in the study of @entity5 .
