Effect of active @entity281 on cytochrome P450-mediated metabolism of @entity205 in renal transplant XXXX .

@entity1 @entity9472 @entity409 @entity2348 @entity205 @entity281 @entity1011
BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity205 ( @entity9472 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity2348 on @entity9472 metabolism were studied in renal transplant @entity1 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity1 , diagnosed with fungal or @entity2348 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity9472 was performed at least 1  week before the onset of @entity281 . Exclusion criteria were @entity1 with acute or chronic unstable @entity409 , elderly @entity1 , and @entity1 on concomitant drugs affecting @entity9472 metabolism. @entity9472 trough levels and serum @entity1011 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity281 , during @entity281 and in many cases, post @entity281 . RESULTS: @entity9472 trough levels and SCR concentrations increased significantly during the @entity281 (P  <  0.001, P  =  0.002) respectively. Of the @entity1 , 87% experienced a concomitant rise in @entity9472 trough level and SCR concentrations. No significant difference between pre- @entity281 and post- @entity281 levels of @entity9472 trough and SCR was found. CONCLUSIONS: @entity9472 trough and SCR levels increased during @entity2348 and returned to pre- @entity281 levels once the @entity281 was resolved. The data generated stress the importance of monitoring @entity9472 levels during episodes of @entity281 . Our recommendations concerning @entity9472 dose adjustment differ according to severity and duration of @entity281 .
