The distribution of hyaluronan in human skin and mature, XXXX .

@entity8274 @entity15773 @entity2805
A @entity8274 ( @entity8274 ) was used to locate the distribution of @entity15773 in normal skin and in various types of scar tissue: mature scar tissue, @entity2805 and keloids. The study was intended to establish whether or not a deviant @entity15773 distribution could explain the different clinical features of these scar tissues. The distribution of @entity15773 was found to differ between the various scar tissues. In normal skin an intense @entity15773 -staining was observed in the papillary dermis. In mature scar tissue the distribution of @entity15773 resembled that of normal uninjured tissue, but the layer of @entity15773 was thinner. In @entity2805 , @entity15773 occurred mainly as a narrow strip in the papillary dermis. Keloid tissue showed the least @entity15773 -staining of the papillary layer and resembled that of the bulging reticular dermis. In contrast, the thickened granular and spinous layer of the keloid epidermis exhibited an intense @entity15773 -staining. We suggest that the altered distribution and amount of @entity15773 in these different scar tissues may contribute to their different clinical characteristics. This histochemical technique for the demonstration of @entity15773 in scar tissue could be of use in clinical work to decide on therapeutic strategies.
