Plasma lipoprotein-associated phospholipase A2 in @entity1 with XXXX and @entity2998 .

@entity1 @entity1004 @entity1989 @entity6511 @entity2998 @entity209 @entity731 @entity165
BACKGROUND: Lipoprotein-associated phospholipase A    (Lp- @entity1989   ) is a recently identified and potentially useful plasma biomarker for cardiovascular and @entity731 . However, the correlation between the Lp- @entity1989    activity and @entity2998 remains poorly investigated in @entity1 with @entity209 ( @entity209 ). The present study aimed to evaluate the potential role of Lp- @entity1989    as a comprehensive marker of @entity209 in individuals with and without @entity2998 . METHODS: We documented 118 consecutive @entity1 with @entity209 and 70 age- and sex-matched healthy subjects served as controls. The @entity1 were further divided into two groups: 39 with carotid plaques and 79 without carotid plaques to elucidate the influence of Lp- @entity1989    on @entity2998 . The plasma Lp- @entity1989    activity was measured by using ELISA method and carotid @entity1004 ( @entity1004 ) was performed by ultrasound in all @entity1 . RESULTS: Lp- @entity1989    activity was significantly increased in @entity209 subgroups when compared with controls, and was higher in @entity1 with carotid plaques than those without plaques (P < 0.05). Furthermore, we found that significant difference in Lp- @entity1989    was obtained between @entity1 with three and four disorders of @entity209 (P < 0.01). Age (b = 0.183, P = 0.029), LDL- @entity165 (b = 0.401, P = 0.000) and waist-hip ratio (b = 0.410, P = 0.000) emerged as significant and independent determinants of Lp- @entity1989    activity. Multiple stepwise regression analysis revealed that LDL- @entity165 (b = 0.309, P = 0.000), systolic blood pressure (b = 0.322, P = 0.002) and age (b = 0.235, P = 0.007) significantly correlated with max @entity1004 , and @entity6511 was not an independent predictor for @entity1004 . CONCLUSIONS: Lp- @entity1989    may be a modulating factor for @entity1004 via age and LDL- @entity165 , not independent predictor in the pathophysiological process of @entity2998 in @entity1 with @entity209 .
