Impact of acid secretion, XXXX , and mucus thickness on gastric transfer of antibiotics in @entity35 .

@entity32 @entity10026 @entity868 @entity115 @entity4581 @entity8867 @entity3621 @entity1534 @entity35 @entity4546
BACKGROUND AND AIMS: The success of @entity1534 eradication regimens depends on gastric pH, @entity32 , and mucus thickness. Our aim was to investigate the effects of acid secretion, @entity32 , and mucolysis on gastric antibiotic transfer. SUBJECTS AND METHODS: A total of 134 anaesthetised @entity35 were given @entity868 , @entity115 , or @entity4581 intravenously and gastric contents were aspirated via an indwelling cannula. Acid secretion was controlled by either @entity4546 or @entity10026 while @entity3621 was induced by infection with @entity1534 or dosing with @entity8867 . Mucolysis was achieved by instilling pronase into the gastric lumen. RESULTS: @entity868 transfer increased with acid secretion and fell with @entity4546 , independently of gastric pH. @entity4581 was also transferred with acid but was then rapidly degraded. @entity4546 prevented this degradation, raising gastric luminal concentrations. @entity4546 did not alter @entity115 transfer. @entity3621 induced by @entity1534 did not alter gastric transfer of @entity868 and @entity115 but that of @entity4581 was increased by 23%. However, @entity3621 induced by @entity8867 reduced @entity4581 transfer without any effect on @entity868 or @entity115 transfer. Pronase treatment increased @entity115 transfer fourfold and @entity868 by 66% but reduced @entity4581 transfer by 35%. CONCLUSIONS: @entity868 and @entity4581 are predominantly transferred with gastric acid rather than by an acid trapping mechanism. Pronase increases the appearance of @entity115 and @entity868 in gastric secretions.
