Imaging studies in Freund's complete adjuvant model of regional @entity625 , a model suitable for the study of @entity158 mechanisms, in the XXXX .

@entity32 @entity1931 @entity625 @entity8650 @entity2681 @entity16 @entity1324 @entity3795 @entity158 @entity35 @entity85
OBJECTIVE: In view of the extensive distribution in the spinal cord of primary afferent nociceptive nerve fibers from the @entity35 hind paw, a model of regional @entity32 would be useful in the study of @entity158 . However, the subcutaneous intraplantar injection of a single low dose of Freund's complete adjuvant ( @entity3795 ) has been used mostly as an @entity32 model. We undertook this study to characterize this model by means of conventional radiography, microfocal computed tomography, and bone densitometry and by examining changes in @entity158 -related behavior. METHODS: Male @entity35 were injected unilaterally with @entity3795 or saline subcutaneously in the hind paw and killed 7, 15, and 30 days after injection. @entity158 -related behavior was studied using the Hargreaves, von Frey, and @entity1324 tests. RESULTS: @entity3795 -injected animals developed @entity8650 and @entity625 restricted to the joints of the injected hind paw. No signs of joint involvement were observed 7 days after @entity3795 injection. On day 15 after @entity3795 injection, there was widening of joint space indicative of joint effusion. By day 30 after @entity3795 injection, there was evidence of @entity16 with joint space narrowing, @entity2681 , @entity85 . There were no changes contralaterally or in saline-injected @entity35 . @entity1931 and cold @entity1931 were present in the affected hind paw from day 1 through day 30. CONCLUSION: Signs of @entity625 were strictly unilateral and started only 2 weeks after injection. Since the affected area has a broad representation in the spinal cord, this model has advantages over monarthritis models for the study of plastic changes in the dorsal horn of the spinal cord.
