Comparative Neuroregenerative Effects of C-Phycocyanin and XXXX in a Model of @entity15 in @entity19 .

@entity19 @entity12421 @entity6172 @entity9674 @entity1234 @entity6503 @entity636 @entity15
UNASSIGNED: @entity15 ( @entity15 ) therapies approved so far are unable to effectively reverse the chronic phase of the disease or improve the remyelination process. Here our aim is to evaluate the effects of C-Phycocyanin (C-Pc), a biliprotein from Spirulina platensis with anti-oxidant, anti-inflammatory and cytoprotective properties, in a chronic model of @entity6503 ( @entity6503 ) in @entity19 . C-Pc (2, 4 or 8  mg/kg  i.p.) or @entity12421 (2000  IU, s.c.) was administered daily once a day or every other day, respectively, starting at disease onset, which differ among @entity6503 @entity19 between 11 and 15  days postinduction. Histological and immunohistochemistry (anti- @entity9674 , anti-CD3 and anti-APP) assessments were performed in spinal cord in the postinduction time. Global gene expression in the brain was analyzed with the Illumina @entity19 WG-6_V2 BeadChip microarray and the expression of particular genes, assessed by qPCR using the Fast SYBR Green RT-PCR Master Mix. Oxidative stress parameters ( @entity1234 , peroxidation potential, CAT/SOD ratio and @entity6172 ) were determined spectrophoto-metrically. Results showed that C-Pc ameliorates the clinical deterioration of animals, an effect that expresses the reduction of the inflammatory infiltrates invading the spinal cord tissue, the axonal preservation and the down-regulation of @entity636 expression in brain tissue and serum. C-Pc and @entity12421 improved the redox status in @entity19 subjected to @entity6503 , while microarray analysis showed that both treatments shared a common subset of differentially expressed genes, although they also differentially modulated another subset of genes. Specifically, C-Pc mainly modulated the expression of genes related to remyelination, gliogenesis and axon-glia processes. Taken together, our results indicate that C-Pc has significant therapeutic effects against @entity6503 , mediated by the dynamic regulation of multiple biological processes.
