Changes in the concentration of XXXX and placental hormones following two methods of medical abortion in early pregnancy.

@entity1 @entity548 @entity1420 @entity53 @entity160 @entity3927 @entity4999
OBJECTIVE: Measurement of @entity160 ( @entity160 ) was used to investigate the occurrence of feto-maternal @entity548 in @entity1 undergoing medical abortion. DESIGN: Three groups of @entity1 with @entity4999 of 56 or less days were studied. A control and a @entity3927 group had two blood samples taken 48 h apart. @entity1 undergoing medical abortion with gemeprost had two blood samples taken 24 h apart. SETTING: Medical Termination Unit, Simpson Memorial Maternity Pavilion, Edinburgh. SUBJECTS: Three hundred and thirty-five @entity1 requesting abortion. INTERVENTIONS: Blood samples taken at 24 h or 48 h apart. MEASUREMENTS AND MAIN RESULTS: The rise in concentration of @entity160 in plasma was much higher (P = 0.01) in the two groups of @entity1 in whom abortion was induced by gemeprost or @entity3927 than in control @entity1 . Whereas only 5% of @entity1 in the control group had a significant rise in @entity160 , 27% and 33% of @entity1 in the @entity3927 and gemeprost groups, respectively, had a rise in @entity160 level which exceeded the 95th centile (> or = 38%). The concentration of hCG rose by 48 h in both control and @entity3927 groups. @entity1420 remained unchanged, and @entity53 decreased (P < 0.02) in the @entity3927 group. By 24 h, there was a significant fall in the concentrations of hCG, @entity1420 and @entity53 in the group who had aborted after being given gemeprost. CONCLUSIONS: Anti-D prophylaxis must be administered to rhesus negative @entity1 to avoid rhesus iso-immunisation.
