Prognostic factors for survival after curative resection of Dukes' B XXXX .

@entity1 @entity694 @entity5
AIM: Data on the prognostic factors for survival in @entity1 with locally advanced, node-negative @entity694 are limited. This study aimed to determine which factors might predict survival in @entity1 with Dukes' B (T3 or T4, N0) @entity694 . METHOD: One hundred and eighty (93 male; median age 75 [range, 38-96] years) consecutive @entity1 who had resection of a primary Dukes' B (on final histopathological analysis) @entity694 between 1998 and 2003 were studied. No @entity1 received neoadjuvant chemotherapy. Multivariate Cox regression modelling was used to assess the prognostic value of variables. Median follow up was 85 (60-125) months. RESULTS: Thirteen (7%) @entity1 had a perforation at presentation. The median distance from @entity5 to the nearest longitudinal resection margin was 6 (0.3-27) cm. One hundred and twenty-four (69%) @entity1 had a lymph node yield of 12 or more nodes. Actual 5-year survival was 59%. On multivariate regression analysis, @entity5 perforation (perforation vs no perforation, 5-year survival, 23%vs 61%; hazard ratio (HR), 3.7; 95% confidence interval (CI), 1.6-8.4; P = 0.002), @entity5 -to-margin distance (< 5 cm vs >=  5 cm, 48%vs 65%; HR, 1.7; 95% CI, 1.1-2.7; P = 0.039) and older age (>=  75 years vs < 75 years, 45%vs 72%; HR, 3; 95% CI, 1.8-5; P < 0.001) were independent significant variables. CONCLUSION: A lymph node yield of 12 or more nodes is not a significant prognostic factor for survival after resection of Dukes' B @entity694 . @entity1 with @entity5 perforation or limited resection have worse prognosis.
