Increased XXXX after Transfusion of Leukoreduced Non-Irradiated Blood Products in Recipients of Allogeneic Stem Cell Transplants after Reduced-Intensity Conditioning.

@entity1 @entity33 @entity2348 @entity281 @entity1398 @entity2132 @entity221
UNASSIGNED: Blood components transfused to hematoprogenitor stem cell transplant (HSCT) recipients are irradiated to prevent @entity2132 ( @entity2132 ). The effect of transfusing non-irradiated blood products in HSCT outcome, including incidence of transplant complications, @entity2348 , acute and chronic GVHD presentation, and characteristics, has not been documented. Clinical records as well as blood bank and electronic databases of HSCT @entity1 grafted after reduced-intensity conditioning who received irradiated versus non-irradiated blood products, after blood irradiation became unavailable at our center, were scrutinized for transplant outcome, clinical evolution, engraftment characteristics including days to neutrophil and platelet recovery, acute and chronic GVHD, rate and @entity281 , and additional transplant-related comorbidities. All transfused blood products were leukoreduced. A total of 156 HSCT recipients was studied, 73 received irradiated and 83 non-irradiated blood components. @entity2348 were significantly more frequent in @entity1 transfused with non-irradiated blood products, P  = .04. Clinically relevant increased rates of @entity221 and @entity1398 and @entity33 were also documented in these @entity1 . No cases of @entity2132 occurred. Classical GVHD developed in 37 @entity1 (50.7%) who received irradiated blood products and 36 (43.9%) who received non-irradiated blood products, P  = .42. Acute GVHD developed in 28 @entity1 (38.4%) in the blood-irradiated and 33 @entity1 (39.8%) in the non-irradiation group, P  = .87. The 2-year GVHD-free survival rate was 40% in the irradiated versus 40.6% in the non-irradiation group, P  = .071. Increased @entity2348 were found in HSCT recipients transfused with non-irradiated blood products, which ideally must always be irradiated.
