A randomized clinical trial of preoperative versus postoperative XXXX in elective cesarean delivery.

@entity190 @entity1 @entity396
OBJECTIVE: To determine the optimum time for @entity396 administration to minimize @entity190 during and after elective cesarean delivery. METHODS: A randomized clinical trial was conducted at Mansoura University Hospital, Egypt, between January 1, 2013, and December 31, 2014. Eligible @entity1 had full-term pregnancies, were scheduled to have a cesarean, and had normal fetal heart tracing. @entity1 were randomly allocated into two equal groups using computer-generated tables and sealed opaque envelopes. @entity396 (400 g, given rectally) was given either before (group 1) or after (group 2) surgery. @entity1 , investigators, and data analysts were not masked to group assignment. The primary outcome was @entity190 . RESULTS: A total of 348 @entity1 were included (174 in each group). @entity190 was significantly lower in group 1 than in group 2 (570  240 vs 844  270mL; P<0.001). The frequency of maternal and neonatal adverse events did not differ between the groups. CONCLUSION: Preoperative @entity396 (400 g, given rectally) reduces @entity190 to a greater extent than does postoperative @entity396 during elective cesarean delivery. The frequency of complications was not affected by time of administration.
