Comparison of @entity19 and @entity1 Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related XXXX .

@entity1 @entity8173 @entity19 @entity1939 @entity989 @entity1020
BACKGROUND: The @entity1 @entity989 ( @entity989 ) plays an important role in the pathogenesis of @entity1020 ( @entity1020 ). @entity1020 is the leading cause of @entity1939 worldwide. There is currently no effective treatment available. Preclinical studies in @entity1020 @entity19 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity19 and @entity1 @entity989 . METHODS: We performed a microarray study to identify and functionally annotate @entity989 specific gene expression in @entity19 and @entity1 @entity989 . We used a meticulous method to determine C57BL/6J @entity19 @entity989 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity19 and @entity1 @entity989 . RESULTS: We defined sets of @entity19 (64), @entity1 (171) and @entity19 - @entity1 interspecies (22) @entity989 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity19 and @entity1 @entity989 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity989 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity1020 . For example, @entity8173 , most likely the main complement regulator in @entity1020 pathogenesis was highly expressed in @entity1 @entity989 , but almost absent in @entity19 @entity989 . Furthermore, functions assigned to @entity19 and @entity1 @entity989 expression profiles indicate (patho-) biological differences related to @entity1020 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity1020 .
