Combined effect of topical @entity4447 and radiation therapy on skin-infiltrating lesions of XXXX -a pilot study.

@entity1 @entity4447 @entity0 @entity9188 @entity5 @entity344 @entity3 @entity158 @entity236
It has been reported that @entity4447 ( @entity9188 ) is an apoptosis inducer and radiation sensitizer for various @entity5 cell lines. In this study of @entity0 @entity1 , we examined the combined effect of topical @entity9188 and radiation therapy on fungating and/or skin-infiltrating lesions of @entity0 . The dermatological, @entity344 of the treatment were also monitored. @entity9188 gel (0.05%) was applied to @entity5 lesions 1 h prior to delivery of each fraction, with the gel removed about 5 min before the irradiation. Superficial radiation was delivered using an electron beam from a linear accelerator. Every week, the @entity5 lesions were photographed to evaluate effectiveness, and blood was sampled to monitor changes in hemogram and biochemical profile. Seven @entity0 @entity1 with cutaneous @entity3 were enrolled in this study. In terms of @entity5 , the rates for complete, partial response and stable disease were 42.9 (three of seven), 42.9 (three of seven) and 14.3% (one of seven), respectively. The skin @entity158 , assessed by a visual analog scale, and secretion from all of the seven superficial and fungating wounds decreased markedly after treatment. Significant @entity236 or granulocytosis was not noted. Further, changes in renal and hepatic function were also not significant. It seems reasonable to conclude that @entity9188 may be an effective and safe radiosensitizer for palliative radiotherapy for skin-infiltrating lesions of @entity0 .
