Association of genetic variants at 3q22 with @entity8 in @entity1 with XXXX .

@entity1 @entity8 @entity71097 @entity6 @entity2316 @entity71098
@entity2316 ( @entity2316 ) is the primary cause of morbidity and mortality in @entity1 with @entity6 ( @entity6 ) and affects about 30% of these @entity1 . We have previously localized a @entity2316 locus on chromosome 3q with suggestive linkage in Finnish individuals. Linkage to this region has also been reported earlier by several other groups. To fine map this locus, we conducted a multistage case-control association study in @entity6 @entity1 , comprising 1822 cases with @entity8 and 1874 @entity6 @entity1 free of @entity8 , from Finland, Iceland, and the British Isles. At the screening stage, we genotyped 3072 tag SNPs, spanning a 28 Mb region, in 234 @entity1 and 215 controls from Finland. SNPs that met the significance threshold of p < 0.01 at this stage were followed up by a series of sample sets. A genetic variant, @entity71097 , in the noncoding region at 3q22 was associated with increased risk of @entity2316 (overall p = 7.07 x 10(-6), combined odds ratio [OR] of the allele = 1.33). The estimated genotypic ORs of this variant in all Finnish samples suggested a codominant effect, resulting in significant association, with a p value of 4.7 x 10(-5) (OR = 1.38; 95% confidence interval = 1.18-1.62). Additionally, an 11 kb segment flanked by @entity71098 and @entity71097 , two strongly correlated variants (r(2) = 0.95), contains three elements highly conserved across multiple species. Independent replication will clarify the role of the associated variants at 3q22 in influencing the risk of @entity2316 .
