The effects of aerobic endurance exercise on pulse wave velocity and XXXX in adults: A systematic review and meta-analysis.

@entity1 @entity121 @entity122
UNASSIGNED: The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) or cohort studies that evaluated the effect of aerobic endurance exercise on pulse wave velocity ( @entity122 ) and @entity121 ( @entity121 ) in adults. @entity121 and @entity122 were the most commonly used parameters for the assessment of arterial stiffness. The MEDLINE, Cochrane, ISI, and Ovid databases were searched between January 2000 and February 2015. A total of 1654 @entity1 in 26 RCTs and two cohort studies were included in the meta-analysis. In studies for which @entity122 was the outcome, aerobic endurance exercise had a significant effect on reducing @entity122 [-0.67, 95% CI -0.97, -0.38; I(2) =   89%; heterogeneity, P   <   0.0001]. Changes in peripheral arterial @entity122 were statistically greater than in central arterial @entity122 . In the RCTs for which @entity121 was the outcome, changes [-0.04, 95% CI -0.12, 0.04; I(2)    =   95%; heterogeneity, P   <   0.00001] in @entity121 did not reach statistical significance. In the two cohort studies, changes [-8.81, 95% CI -9.25, -8.37; I(2)    =   22%; heterogeneity, P   =   0.26] in @entity121 were statistically significant. Subgroup analysis indicated a longer duration aerobic exercise and a greater improvement in VO2max were associated with larger reductions in @entity122 . Reductions in @entity121 were observed in two cohort studies, but not in four RCTs.
