Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese XXXX .

@entity3294 @entity1 @entity1254 @entity412
Data from cellular systems and transgenic animal models suggest a role of @entity3294 in the regulation of very low-density lipoprotein (VLDL) metabolism. However, the precise mechanism whereby @entity3294 regulates VLDL metabolism remains to be elucidated in @entity1 . In this study, we examined the associations between the kinetics of high-density lipoprotein (HDL)- @entity3294 and VLDL-apoB-100 kinetics, and plasma @entity1254 concentrations. The kinetics of HDL- @entity3294 and VLDL-apoB-100 were measured in 37 nonobese @entity1 using stable isotope techniques. Plasma @entity1254 concentration was measured using immunoassays. Total plasma @entity3294 concentration was positively associated with HDL- @entity3294 production rate (PR) (r = 0.734, P < .01); both were positively associated with plasma @entity412 concentration (r = 0.360 and 0.369, respectively) and VLDL-apoB-100 PR (r = 0.406 and 0.427, respectively), and inversely associated with plasma @entity1254 concentration (r = -0.449 and -0.375, respectively). Plasma @entity1254 was inversely associated with plasma @entity412 concentration (r = -0.327), VLDL-apoB-100 concentration (r = -0.337), and VLDL-apoB-100 PR (r = -0.373). In multiple regression models including waist circumference and plasma insulin, plasma @entity1254 concentration was an independent determinant of total plasma @entity3294 concentration (b-coefficient = -0.508, P = .001) and HDL- @entity3294 PR (b-coefficient = -0.374, P = .03). Conversely, total plasma @entity3294 concentration (b-coefficient = 0.348, P = .047) and HDL- @entity3294 PR (b-coefficient = -0.350, P = .035) were both independent determinants of VLDL-apoB-100 PR. However, these associations were not independent of plasma @entity1254 . Variation in HDL @entity3294 production, and hence total plasma @entity3294 concentration, may exert a major effect on VLDL-apoB-100 production. Plasma @entity1254 may also contribute to the variation in VLDL-apoB-100 production partly by regulating @entity3294 transport.
