Distribution of @entity1364 and XXXX in intraepithelial squamous cell lesions of @entity1 bronchus.

@entity1 @entity1364 @entity470 @entity957 @entity1544 @entity982
Distribution of @entity1364 and @entity470 was studied by immunohistochemistry in intraepithelial squamous cell lesions of @entity1 bronchus. Ten biopsy specimens were examined for each of the following categories of lesions (50 specimens altogether): normal bronchial epithelium, @entity1544 , @entity1544 , and @entity957 in situ, in addition to invasive @entity957 . The percentage positivity of immunoreactive cells and their localization in the epithelium were examined in formalin-fixed, @entity982 -embedded tissues of bronchial biopsy specimens retrieved from the surgical pathology file. @entity1364 positivity ranged from 3.2% (normal bronchial epithelium), to 7.6% ( @entity1544 ), 51.8% ( @entity1544 ), and 85.0% ( @entity957 in situ). The difference between the groups was statistically significant (p < 0.01). The percentage positivity for invasive @entity957 was 56.9%. @entity470 positivity ranged from 7.3% (normal bronchial epithelium), to 38.7% (benign squamous epithelium), 67.5% ( @entity1544 ), and 91.3% ( @entity957 in situ). The difference between the groups was statistically significant (p < 0.01). Invasive @entity957 positivity was 49.7%. Both @entity1364 -positive and @entity470 -positive cells showed zonal distribution in the bronchial epithelium. They were located in the basal cell layer in normal bronchial epithelium and expanded upward as the morphologic changes advanced. In @entity957 in situ, both @entity1364 -positive and @entity470 -positive cells covered the entire thickness of the bronchial epithelial layer.(ABSTRACT TRUNCATED AT 250 WORDS)
