Musculoskeletal ultrasonography in healthy subjects and ultrasound criteria for XXXX (the ESPOIR cohort).

@entity1 @entity79 @entity625 @entity603
OBJECTIVE: To confirm the occurrence of @entity79 and @entity603 in healthy subjects detectable by ultrasound (US) and to establish US criteria for @entity625 . METHODS: Our study involved 127 healthy subjects matched with a cohort of @entity1 with @entity625 (the ESPOIR cohort). The second and fifth metacarpophalangeal (MCP) joints and the fifth metatarsophalangeal (MTP) joint of both hands and feet were assessed with US to detect @entity79 ; and the second, third, fourth, and fifth MCP and the fifth MTP were evaluated for synovial thickening in B-mode US and synovial vascularity in power Doppler. @entity79 and @entity603 were defined according to the Outcome Measures in Rheumatology Clinical Trials consensus. RESULTS: @entity79 and grade 2-3 synovial thickening in B-mode were detected in 11% and 9% of healthy subjects. To consider the diagnosis of @entity625 , a cutoff at 1 case of synovial thickening in B-mode enabled discrimination between @entity1 with @entity625 and healthy subjects, with a good sensitivity of 74.8% (95% CI 67.2%-82.3%) and a high specificity of 90.5% (95% CI 85.4%-95.6%). If higher specificity is required to confirm the diagnosis of @entity625 , cutoff at 2 cases of synovial thickening in B-mode or at 2 cases of @entity79 gave optimal results, with specificity of 98.4% (95% CI 96.2%-100%) and 100%, respectively, and lower sensitivity of 59.8% (95% CI 51.2%-68.3%) and 17% (95% CI 10.5%-23.5%) (area under the curve = 0.85 for @entity603 and 0.63 for @entity79 ). Neither the combination of power Doppler signal plus @entity79 , nor @entity79 plus synovial thickening on the same joint, were seen in healthy subjects. CONCLUSION: A single case of @entity79 or synovial thickening in B-mode is common in healthy subjects. However, more than 1 case of synovial thickening in B-mode or @entity79 is a strong argument for the diagnosis of early @entity625 .
