Effects of @entity3988 , @entity1406 , @entity4688 and XXXX on frequency of ventricular premature complexes.

@entity1 @entity4688 @entity101 @entity944 @entity1184 @entity918 @entity3988 @entity1406 @entity4346 @entity943
@entity943 occur frequently in @entity1 with @entity101 left ventricular (LV) @entity1184 and have been associated with increased incidence of @entity944 . In this study, the effect of various antihypertensive medications on @entity943 was evaluated in 31 @entity101 @entity1 with moderate to severe @entity4346 . @entity1 were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: @entity3988 120 or 240 mg/day, @entity1406 100 or 200 mg/day, @entity4688 10 or 20 mg/day and @entity918 50 or 100 mg/day. Each drug therapy was administered for 4 weeks. The sequence of each treatment was determined at random. Echocardiographic measurements and electrocardiograms were obtained only at baseline. Biochemical measurements and 48-hour Holter monitoring were obtained at baseline and at the end of each treatment. All treatments resulted in a significant but similar decrease in blood pressure. In the group as a whole @entity3988 decreased ventricular premature complexes (VPCs) by 65% (p < 0.05) and @entity1406 by 52% (p = 0.07). @entity4688 and @entity918 had no effect. In 12 @entity1 with > or = 5 VPCs/hour at baseline, @entity3988 and @entity1406 decreased VPCs by 66% (p < 0.05). It is concluded that in @entity101 @entity1 with moderate to severe @entity4346 , both @entity3988 and @entity1406 significantly reduce VPCs.
