Myocardial function and geometry in XXXX subjects with low levels of afterload.

@entity1184 @entity1 @entity101
BACKGROUND: It has been hypothesized that the level of end-systolic wall stress (sigma(m)) is a feedback signal that regulates the level of @entity1184 . Thus, low levels of sigma(m) may signify inappropriate @entity1184 . METHODS: To characterize left ventricular (LV) structure and systolic function in @entity101 subjects with low levels of sigma(m), we studied 763 @entity1 . LV function was studied by midwall stress-shortening analysis. Partition values for sigma(m) were derived from a separate group of normal subjects, and the study population was divided into low stress (group I, n = 136), high stress (group III, n = 157), and intermediate stress group II (n = 470). LV chamber and myocardial function were characterized by relating shortening at the endocardium and at the midwall, respectively, to stress. RESULTS: As expected, group III @entity1 had the highest values for systolic blood pressure and LV cavity size but the lowest values for wall thickness and relative wall thickness. Surprisingly, however, there were no significant differences among stress groups with regard to age or body mass index. Contrary to the hypothesis that low levels of stress are indicative of excessive @entity1184 , there were no significant differences among the 3 groups with regard to LV mass or any form of LV mass index. Furthermore, despite lower mean values for afterload, group I @entity1 had significantly lower values for midwall shortening, and this finding was indicative of reduced myocardial function; stress-shortening plots demonstrated that 28% of group I @entity1 fell below 95% CI compared with 10% of group II and only 5% of group III @entity1 . CONCLUSIONS: @entity101 subjects with low values for sigma(m) have more concentric LV geometry (higher relative wall thickness) and, on average, reduced myocardial function.
