Multifocal XXXX associated with @entity5 are clonal and carry a high mutation burden.

@entity43 @entity1 @entity75 @entity5 @entity189 @entity46 @entity10160 @entity10161
UNASSIGNED: Endometriosis is a significant risk factor for clear cell and @entity43 and is often found contiguous with these @entity5 . Using whole-genome shotgun sequencing of seven @entity43 ( @entity43 ) and targeted sequencing in synchronous @entity46 , we have investigated how this @entity189 may evolve from @entity46 . In every case we observed multiple @entity5 -associated somatic mutations in at least one concurrent @entity75 . @entity10161 and @entity10160 mutations appeared consistently in concurrent @entity46 when present in the primary @entity43 . In several cases, one or more @entity75 carried the near-complete complement of somatic mutations present in the index @entity43 . Ancestral mutations were detected in both @entity5 -adjacent and -distant @entity75 , regardless of any cytological atypia. These findings provide objective evidence that multifocal benign @entity75 are clonally related and that CCCs arising in these @entity1 progress from @entity75 that may already carry sufficient @entity5 -associated mutations to be considered @entity5 themselves, albeit with low malignant potential. We speculate that genomically distinct classes of @entity46 exist and that @entity43 with high mutational burden represents one class at high risk for malignant transformation.    2015 The Authors. The Journal of Pathology published by John Wiley _ Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
