Side effects of XXXX deprivation therapy: monitoring and minimizing @entity137 .

@entity1 @entity172 @entity323 @entity3429 @entity263 @entity11796 @entity101 @entity6 @entity417 @entity137 @entity458 @entity247 @entity1017 @entity6303 @entity342 @entity453 @entity906 @entity1486
The current trends in favor of @entity342 deprivation therapy (ADT) for nonmetastatic @entity263 at the stage of biochemical recurrence or increasing @entity1486 raises the issue of exposing otherwise asymptomatic @entity1 to potential side effects over the longer term. Some of these side effects can have deleterious effects on quality of life, and others may contribute to increased risks for serious health concerns associated with aging. Sexual side effects are the most well-recognized adverse effects from ADT and include loss of libido, @entity323 ( @entity323 ), and hot flashes. Loss of libido is distressing to many @entity1 , and they may not pursue treatments for @entity323 . However, for those who do maintain sexual interest, various remedies are available. The incidence of hot flashes, which may not abate over the course of ADT, is close to 80%. @entity172 , progestin @entity6303 , @entity11796 , @entity906 , and @entity3429 have been shown to alleviate hot flashes and associated symptoms. Physiologic effects, including @entity247 , changes in body composition ( @entity1017 , reduced muscle mass, increase in body fat), and changes in lipids, are less commonly recognized as side effects of ADT. These may lead to an exacerbation of potentially more serious conditions, such as @entity101 , @entity6 , and @entity453 . Loss of bone mineral density, @entity417 , and hair changes also may occur. Additionally, both the diagnosis of @entity263 and the hormonal therapy can cause @entity458 . These side effects need more systematic study in clinical trials. Physicians should be aware of far-reaching consequences of ADT and should incorporate strategies for preventing and managing @entity137 into routine practice.
