[ XXXX : disease course in 3 cases].

@entity1 @entity5 @entity409 @entity1350 @entity13904
INTRODUCTION: @entity13904 is an uncommon @entity1350 , one of intermediate-grade @entity5 . @entity13904 is rare and often associated with multiple site involvement. CASES: Three @entity1 with cutaneous EHE without systemic involvement in one case, with skin, @entity409 in two others cases are reported. One @entity1 is in complete remission after one year. The second @entity1 is stable without treatment after ten years. In the third @entity1 , alpha interferon given for one year don't produce effective results and the lesions do not progress without treatment after eight years of follow-up. DISCUSSION: Cutaneous presentation of EHE is quite variable. After the diagnosis is done, systemic involvement must be detected specially in bone, liver or lung. Metastatic spread or mulitcentric origin of the @entity5 are a matter of controversy. The pathobiologic behavior of EHE is not clearly recognized. Little data are available regarding the results of treatment with alpha interferon.
