The efficacy and safety of 0.75% XXXX vs 0.75% @entity1341 for peribulbar anaesthesia.

@entity1 @entity910 @entity1341 @entity1343 @entity158 @entity65
BACKGROUND: @entity1343 , the S(-)-enantiomer of racemic @entity1341 , is associated with a similar efficacy but a reduced potential for @entity65 than racemic @entity1341 . Thus, this prospective, randomised, double-masked study was undertaken to assess the efficacy and safety of 0.75% @entity1343 vs 0.75% @entity1341 , each with hyaluronidase, for peribulbar anaesthesia. METHODS: A total of 60 @entity1 undergoing elective anterior segment surgery were randomly allocated to receive either agent by a single, inferotemporal peribulbar injection technique, supplemented with a medial canthus injection if necessary. Ocular @entity910 and orbicularis oculi function were assessed by scoring systems at 2 min intervals until satisfactory @entity910 was achieved, and movements were reassessed on the day after surgery to confirm regression of the block. RESULTS: The time taken to reach a state of satisfactory anaesthesia and @entity910 was deemed to be the primary measure of efficacy. Both agents achieved this in a similar median time of 2 min after receiving 5 ml of the injectate, and the treatment difference was not statistically significant (P=0.24). Blood samples from the first 20 @entity1 were taken at intervals up to 4 h. These were analysed for plasma levels and confirmed similar plasma concentration vs time profiles for the two agents. Seven @entity1 in each group (23%) complained of @entity158 on injection but the technique was generally well tolerated. Two @entity1 in the @entity1343 group experienced serious adverse events, but neither was considered related to the study medication. The most common minor post-operative adverse event was prolongation of the local anaesthetic block, which was reported by nine @entity1 (four in the @entity1343 group and five in the @entity1341 group). CONCLUSIONS: @entity1343 and @entity1341 are equally successful in achieving clinically satisfactory peribulbar anaesthesia with few adverse effects.
