Genomic instability in XXXX .

@entity1 @entity5 @entity977 @entity652 @entity105
@entity977 most commonly are identified as small, incidental microadenomas. They however may progress to macroadenoma forming intra and @entity5 which in about 1/3 of cases invade surrounding structures at the time of diagnosis. Mechanism of @entity105 remains still elusive. Because the value of karyotyping is limited by the technical problems related to cytogenetic methods, we studied the spectrum of chromosomal imbalances associated with @entity977 using comparative genomic hybridization (CGH). Copy number aberrations on all 22 autosomes were evaluated by CGH using advanced computer software. In total, fifteen @entity1 were included in the study of 9 non-invasive, 4 invasive and two recurrent @entity652 . The mean age of the @entity1 were 48 years ranging from 36 to 68 years. @entity5 showed hormonal activity. The histogram of all 15 cases representing the DNA imbalances as an incidence curve along each chromosome showed losses particularly for chromosomes 1p, 2q, 4, 5, 6, 11q, 12q, 13q and 18q as well as overrepresentation on 9q, 16p, 17p, 19, 20q. Functioning @entity652 carried more imbalances than non-functioning, specifically deletions on chromosome 4 and 18q as well as overrepresentations of chromosomes 17 and 19. Invasive @entity652 carried more overrepresentations at 1p34 than non-invasive @entity5 . Recurrent @entity652 harbored more alterations than @entity5 , particularly DNA gains. The primary data is accessible at our CGH online @entity5 database at http://amba.charite.de/cgh. Reviewing the existing literature on the genetics of @entity977 and discussing our results in this context, we hope that our study will contribute to the knowledge of this @entity5 .
