Evaluation of the Association Between Common Genetic Variants Near the XXXX Gene and Primary Angle Closure Glaucoma in a Han Chinese Population.

@entity71582 @entity725 @entity71583 @entity71579 @entity71578 @entity71581 @entity71580 @entity21123 @entity71577 @entity2747
Purpose: Recently, three large genome-wide association studies have identified multiple variants associated with @entity725 ( @entity725 ) near the @entity21123 gene. Considering that @entity725 and primary @entity2747 (PACG) share many similar clinical manifestations, the present study was conducted to investigate whether these genetic variants were also associated with PACG in a Han Chinese population. Methods: A case-control association study of 1122 cases (PACG/PAC) and 1311 normal, matched controls was undertaken. Seven single-nucleotide polymorphisms (SNPs) near the @entity21123 gene, including @entity71577 , @entity71578 , @entity71579 , @entity71580 , @entity71581 , @entity71582 , and @entity71583 , were genotyped. Genotype and allele frequencies were assessed using   2 tests. Linkage disequilibrium (LD) structure was analyzed by computer software. Results: Among the SNPs genotyped, no association was observed between these SNPs and PACG. However, we discovered that two haplotypes, CATTTAC (corrected P = 0.048) and CGCCCGC (corrected P = 0.048), remained significantly associated with PACG/PAC after Bonferroni correction. Subjects with the CATTTAC haplotype have a 1.71-fold increased possibility of having PACG/PAC, whereas subjects with the CGCCCGC haplotype have 0.47-fold decreased possibility of developing PACG. Conclusions: Our findings suggest that the genetic backgrounds of PACG and @entity725 might be different. However, whether or not @entity21123 plays a role in the development of PACG is still not made certain by this study. Thus, further research is needed to find the role of @entity21123 in the progress of PACG.
