Downregulated microRNA-155 expression in peripheral blood mononuclear cells of @entity2175 XXXX is not correlated with increased inflammatory cytokine production.

@entity1 @entity650 @entity2175 @entity558 @entity6 @entity10015 @entity310 @entity413
OBJECTIVES: The role of @entity10015 in immune responses of PBMCs of @entity2175 ( @entity2175 ) @entity1 has not been studied. DESIGN AND METHODS: 20 Healthy and 20 @entity2175 subjects were participated in the study. @entity10015 expression in PBMCs of the subjects was measured using real-time PCR. The levels of secreted @entity650 and @entity310 cytokines were quantified using ELISA. RESULTS: A downregulation of @entity10015 expression was observed in untreated and @entity558 treated PBMCs of @entity6 @entity1 compared to controls. There was a significant upregulation of @entity10015 after @entity558 treatment in PBMCs of both control and @entity6 groups. In healthy subjects and in both untreated and @entity558 -treated conditions, @entity10015 expression was negatively correlated with weight, waist circumference and body mass index. In @entity6 group, there was a negative correlation between @entity10015 expression and @entity413 levels only in @entity558 treated cells. Furthermore, systolic blood pressure was found to negatively correlate with @entity10015 expression in untreated PBMCs of both healthy and @entity6 subjects. The results also showed a significant correlation between @entity10015 expression and @entity310 and @entity650 levels in @entity558 treated cells. CONCLUSIONS: Our data demonstrate that @entity10015 expression is reduced in PBMCs of @entity6 @entity1 and this reduced expression does not seem to be involved in increased cytokine production from PBMCs of these @entity1 .
