Apoptosis in the epididymal epithelium of adult male XXXX exposed to @entity4742 .

@entity172 @entity251 @entity4743 @entity329 @entity4742
Apoptosis in the testis and prostate exposed to disrupters of endocrine function, including @entity4742 ( @entity4743 ), during neonatal or postnatal periods has repeatedly been demonstrated, but not in the mature epididymis. We investigated the effects of @entity4743 , a potent and synthetic @entity172 , on apoptosis in the adult. Adult male @entity329 received an SC injection of @entity4743 and were then sacrificed to collect epididymides after 1, 4, or 7 days of treatment. A significant decrease in epididymal weight and an increase in apoptotic cells were shown on the first day after @entity4743 injection. Flow cytometry showed that @entity4743 treatment (1 mg/kg) for 1, 4, or 7 days induced significant apoptosis both in the caput and the cauda epididymides. Greater numbers of apoptotic cells were detected in the caput than in the cauda at a fixed time after @entity4743 treatment. Serum levels of @entity251 decreased markedly within 24 hr after @entity4743 administration, reaching undetectable levels of 0.1 ng/ml at 4 days and thereafter. These results indicate that @entity4743 administration can increase epididymal apoptosis with a decrease in serum @entity251 levels. Because @entity4743 used to be injected into domestic animals, adult males also have a chance to take this substance through food. Our study indicates that exposure to @entity4743 in adults is as toxic as that in the perinatal period.
