Proximal axonal changes after XXXX in @entity1 .

@entity1 @entity4094 @entity713 @entity1897 @entity130
@entity1897 leads to changes in the proximal axon. @entity130 in @entity1 were investigated to characterize such electrophysiological changes. Mixed nerve conduction studies (MNCS) and @entity713 ( @entity713 ) were performed proximal to the injury. Control values were obtained from the uninjured limb. Median (n = 24) and ulnar (n = 35) nerve injuries were studied. The injured nerves had significant mixed nerve action potential (MNAP) amplitude reductions (median: P < 0.0001; ulnar: P < 0.0001). The majority of the MNAP amplitude reductions were severe and early. There was slowing in the mixed nerve conduction velocity (MNCV) (median: P = 0.09; ulnar: P = 0.04) and motor conduction velocity (MCV) (median: P = 0.046; ulnar: P = 0.005). Axonal loss appears to play a significant role in producing the MNCS changes observed, and its early occurrence is noteworthy. @entity4094 could be secondary to the effects of injury as well as collateral sprouting of uninjured axons. Proximal axonal changes may have an impact on recovery.
