The effects of morphine, naloxone, and k opioid manipulation on endocrine functioning and social behavior in monogamous XXXX (Callicebus cupreus).

@entity31901 @entity20388 @entity34773 @entity6253
UNASSIGNED: The   opioid receptor ( @entity6253 ) and @entity31901 ( @entity31901 ) have been implicated in pair-bond formation and maintenance in socially monogamous species. Utilizing monogamous @entity20388 (Callicebus cupreus), the present study examined the potential role opioids play in modulating the response to separation, a potent challenge to the pair-bond. In Experiment 1, paired male @entity20388 were separated from their pair-mate for 30-min and then received saline, naloxone (1.0mg/kg), morphine (0.25mg/kg), or the @entity31901 agonist, U50,488 (0.01, 0.03, or 0.1mg/kg) in a counter-balanced fashion, immediately prior to a 30-min reunion with their mate. Blood samples were collected immediately prior to and after the reunion. Males receiving morphine approached females less, initiated contact less, and females broke contact with the males less. The increase in cortisol in response to naloxone was greater compared to vehicle, and the increase in cortisol in response to the high dose of U50,488 compared to vehicle approached significance. In Experiment 2, paired males were treated with the @entity31901 antagonist, @entity34773 (0.1, 0.3, or 1.0mg/kg), or saline 24h prior to a 60-min separation from their mate. Blood samples were collected at the time of injection and immediately before and after separation. Administration of the low dose of @entity34773 decreased the locomotor component of the separation response compared to vehicle. The present study found that the opioid system is involved in both the affiliative and separation distress components of a pair-bond, and these components are regulated by different opioid receptors.
