Accuracy of i-Scan for Optical Diagnosis of XXXX : A Meta-Analysis.

@entity1 @entity694 @entity1127 @entity1586
BACKGROUND: i-Scan is a novel virtual chromoendoscopy system designed to enhance surface and vascular patterns to improve optical diagnostic performance. Numerous prospective studies have been done to evaluate the accuracy of i-Scan in differentiating @entity694 from non-neoplasms. i-Scan could be an effective endoscopic technique for optical diagnosis of @entity1586 . OBJECTIVE: Our aim of this study was to perform a meta-analysis of published data to establish the diagnostic accuracy of i-Scan for optical diagnosis of @entity1586 . METHODS: We searched PubMed, Medline, Elsevier ScienceDirect and Cochrane Library databases. We used a bivariate meta-analysis following a random effects model to summarize the data and plotted hierarchical summary receiver-operating characteristic (HSROC) curves. The area under the HSROC curve (AUC) serves as an indicator of the diagnostic accuracy. RESULTS: The meta-analysis included a total of 925 @entity1 and 2312 @entity1127 . For the overall studies, the area under the HSROC curve was 0.96. The summary sensitivity was 90.4% (95%CI 85%-94.1%) and specificity was 90.9% (95%CI 84.3%-94.9%). In 11 studies predicting @entity1127 histology in real-time, the summary sensitivity and specificity was 91.5% (95%CI 85.7%-95.1%) and 92.1% (95%CI 84.5%-96.1%), respectively, with the AUC of 0.97. For three different diagnostic criteria (Kudo, NICE, others), the sensitivity was 86.3%, 93.0%, 85.0%, respectively and specificity was 84.8%, 94.4%, 91.8%, respectively. CONCLUSIONS: Endoscopic diagnosis with i-Scan has accurate optical diagnostic performance to differentiate neoplastic from non-neoplastic @entity1127 with an area under the HSROC curve exceeding 0.90. Both the sensitivity and specificity for diagnosing @entity1586 are over 90%.
