Neoadjuvant proton beam irradiation followed by transscleral resection of XXXX in 106 cases.

@entity1 @entity5 @entity1939 @entity2184 @entity3
AIMS: To describe results after neoadjuvant proton beam irradiation followed by transscleral resection of large @entity2184 . METHODS: Retrospective interventional case series, including 106 consecutive @entity1 . @entity5 control, enucleation and @entity3 development were assessed with survival curves. Predictors of local recurrence and @entity3 were investigated with log-rank testing. RESULTS: Mean follow-up was 3.2   years. Local recurrence occurred in five cases with an estimated risk of 4.2% and 10.4% at 3 and 5   years after treatment, respectively. Enucleation was performed in 10 cases with an estimated risk of 9.2% and 18.4% at 3 and 5   years, respectively. Significant risk factors for local recurrence were not evident. @entity3 was estimated to occur in 28.4% at 3   years and 40.3% at 5   years, correlating with @entity1 's age only (p=0.01). Seventy four @entity1 (69.8%) underwent vitreoretinal surgery for complications after @entity5 resection. Median visual acuity (VA) was 20/50 at diagnosis and 20/400 in the third year after treatment. VA preservation of 20/200 or better was achieved in 33 @entity1 (31.1%). CONCLUSION: Neoadjuvant proton beam irradiation may help to prevent local recurrence after transscleral resection. Additional vitreoretinal surgery was frequently needed in the presented series. The majority of @entity1 avoided enucleation and functional @entity1939 .
