Reduced in vitro erythroid progenitor cell growth in XXXX .

@entity1 @entity417 @entity5
Peripheral blood and bone marrow were studied in 21 @entity1 with disseminated untreated @entity5 in an attempt to define abnormalities of erythropoiesis associated with the development of @entity417 . Haemoglobin concentration at or below 13 g/dl was present in 13 cases. Marrow morphology was normal in all cases except one, in which small numbers of @entity5 cells were found. Clonal assay of erythroid progenitors showed a significant decrease in the number of BFU-E (p = 0.03) and CFU-E (p = 0.01) compared with cultures from normal marrow (12 subjects). The growth of granulocyte and macrophage progenitors (GM-CFCs) was similar in @entity1 with @entity5 and normal subjects. When normal marrow was incubated in the presence of serum from @entity5 @entity1 , no inhibitory factors could be detected either for BFU-E or CFU-E growth. In all @entity1 circulating T8 numbers were significantly raised (p = 0.0002). Consequently, the median T4:T8 ratio in blood was 1.2, and this was significantly lower than the ratio of 1.7 found in 20 normal subjects (p = 0.036). In 18 @entity1 the bone marrow T4:T8 ratio of 1.1 was significantly lower than the ratio of 2.9 found in seven normal subjects (p = 0.04). Total blood white cell counts, neutrophils, and monocyte numbers were also increased (p = 0.0001; p = 0.0001; p = 0.002).
