Local anaesthetic wound infiltration after internal fixation of XXXX : a randomized, double-blind clinical trial in 33 @entity1 .

@entity1 @entity2249 @entity390 @entity1337 @entity1342 @entity158
Abstract: @entity158 control may assist early mobilisation after internal fixation of @entity2249 . Systemic opioids have significant side effects in elderly @entity1 . We present an evaluation of the effect of local anaesthetic infiltration in such cases , the objective being to decrease the need for postoperative opioids and to improve @entity158 control for @entity1 after surgery. 33 @entity1 undergoing internal fixation with 2 parallel hook pins were randomized into 2 groups in a double blind study (ClinicalTrials.gov: NCT00529425). 33 @entity1 received intraoperative infiltration followed by 6 postoperative injections through an intraarticular catheter in eight-hour intervals. 19 @entity1 received @entity1342 and 14 received saline. The intervention period was 48 hours and the observation period was 5 days. In both groups there were no restrictions on the total daily dose of rescue analgesics. @entity158 was assessed at specific postoperative time-points and the daily consumption of opioid drugs needed for @entity1337 was registered. There was no significantly reduced consumption of standardized opioid rescue analgesics or @entity158 in the study group receiving @entity1342 injections. Apart from a reduction in @entity390 in the study group on the second postoperative day, there were no significant differences in the occurrence of side effects between the groups. On day 2 the placebo group had less @entity158 than the study group. Local anaesthetic infiltration after fixation of @entity2249 does not reduce opioid consumption or @entity158 '.
