Sequential changes of sonographic and computed tomography findings in the normal @entity95 liver after percutaneous XXXX injection. Correlation with pathologic findings.

@entity82 @entity41 @entity39 @entity5 @entity95 @entity8681 @entity715 @entity99 @entity1068
RATIONALE AND OBJECTIVES: The authors assessed the sequential sonographic and computed tomographic (CT) findings and their correlations with pathologic findings of the normal @entity95 liver after percutaneous @entity1068 injection ( @entity8681 ). METHODS: In 30 anesthetized @entity95 , 1 mL of @entity1068 was injected percutaneously under sonographic guidance. The animals were divided into five groups of six @entity95 each according to the times of sonography and CT examinations after @entity8681 : day 1 (immediately after), day 3, week 1, week 2, and week 4. The radiologic findings were analyzed regarding echogenicity (sonography) and density patterns before and after contrast administration (CT). The relations between radiologic findings and pathologic findings were examined using statistical analysis. The lesion size was measured using sonography and CT and compared with the actual size of the pathologic specimen. RESULTS: Sonography and CT showed various radiologic findings according to the time elapsed after @entity8681 . The livers were hyperechoic in 100% (6/6) of the @entity95 on day 1; this changed to isoechoic (67%, 12/18) or slightly hypoechoic (22%, 4/18) after week 1 through week 4 after @entity8681 on sonography. CT scanning showed well-defined, hypodense lesions with no contrast enhancement in 100% (6/6) of the @entity95 on day 1, and the lesions were slightly hypodense and relatively poorly defined in 88% (21/24) after day 3. Peripheral enhancement was noted in 83% (15/18) after week 1. Histopathologic examination revealed @entity715 and @entity99 correlating well with hyperechogenicity on sonography and very low density on CT immediately after @entity8681 . Coagulation @entity39 was a main pathologic finding in the central portion of the lesions after day 3 and correlated with the CT findings of central low density without contrast enhancement. After week 1, peripheral granulation tissue and @entity82 were correlated with peripheral contrast enhancement on CT. Lesion size was largest in the week 1 group, and the size difference was statistically significant between the week 1 group and the day 1 group. CONCLUSIONS: Sonographic and CT findings of the @entity8681 -treated normal @entity95 liver varied with time in a predictable manner and correlated with pathologic findings. After a week, the @entity8681 -treated normal liver shows perilesional enhancement that is nodular and irregular (particularly until 2 weeks); this must be taken into account when evaluating the therapeutic effect after @entity8681 using conventional CT studies. Although long-term data are missing, control CT scans for @entity41 should not be performed before the second week after @entity8681 because of the difficulty discerning enhancing @entity5 from enhancing @entity82 .
