Prognostic Implications of Antibodies to @entity16683 in XXXX : A PRISMA-Compliant Meta-Analysis.

@entity1 @entity6571 @entity23114 @entity16683 @entity1578 @entity99 @entity775
UNASSIGNED: Prognostic evaluation is important for the management of @entity1 with @entity775 ( @entity775 ). Although some autoantibodies have been associated with disease activity and outcomes, the implication of antibodies to @entity16683 (anti- @entity23114 ) remains controversial.To conduct a meta-analysis of observational studies which addressed differences in clinical characteristics by anti- @entity23114 status in @entity1 with @entity775 .Three databases PUBMED, EMBASE, and OVID were systemically searched up to January 2015 using the terms " @entity16683 " or "liver-pancreas antigen" and " @entity775 " with restriction to English-language.Studies were included if at least 50 @entity1 with objective diagnosis of @entity775 were enrolled, anti- @entity23114 detection was performed for the @entity1 , and prognostic outcomes and/or disease severity were reported.Two investigators independently reviewed retrieved literature and evaluated eligibility. Discrepancy was resolved by discussion and a third investigator. Quality of included studies was evaluated using Newcastle-Ottawa Quality Assessment Scale (NOS). Data were pooled using fixed-effect or random-effect models.Prognostic outcomes included death from @entity1578 or requirement for liver transplantation, and responses to immunosuppressive therapy regarding remission or relapse. Results were combined on the odds ratio (OR) or standardized mean difference (SMD) scales.Eight studies were enrolled in this study, involving a total of 1297 @entity775 @entity1 among whom 195 with anti- @entity23114 . Pooled serum @entity6571 levels tended to be lower in anti- @entity23114 seropositive @entity1 . The presence of anti- @entity23114 conferred 3.1-fold increased risk of @entity99 in @entity775 @entity1 . The remission rates were comparable between anti- @entity23114 seropositive and seronegative @entity775 patients, while anti- @entity23114 positivity was associated with nearly 2-fold increased risk of relapse after drug withdrawal. Human leukocyte antigen (HLA) allotype DR3 was positively associated with anti- @entity23114 .Antibodies to @entity23114 may be an indicator of increased risks of @entity99 and treatment relapse for @entity775 @entity1 . Our findings suggest that the anti- @entity23114 seropositive @entity1 should be maintained indefinitely on individually adjusted medication to improve their prognosis.
