Kefir induces apoptosis and inhibits cell proliferation in human XXXX .

@entity13352 @entity39 @entity5 @entity2667 @entity1735 @entity6007 @entity3052 @entity98 @entity6674 @entity880 @entity375
UNASSIGNED: @entity13352 is an uncommon subtype of @entity3052 which has been considered to be a subtype of @entity3052 with a worse prognosis. Intensive chemotherapy is the first line of treatment. In recent years, the effect of kefir on some @entity5 has been experimented. Kefir is a kind of beverage, which obtained by incubation of kefir grains with raw milk. Kefir grains are a symbiotic complex of different kinds of @entity375 and bacteria, especially @entity880 bacteria which gather in a mostly @entity1735 matrix, named kefiran. We investigated the effect of kefir on @entity13352 cell line (KG-1) and peripheral blood mononuclear cells (PBMCs). The cell line and PBMCs were treated with different doses of kefir and milk and incubated for three different times. We used Polymixin B to block the lipopolysaccharide and @entity6674 (1  mol/l) to neutralize the acidic media. Viability was detected by @entity98 assay. Apoptosis and @entity39 were assessed by annexin- @entity2667 staining. Our results showed that kefir induced apoptosis and @entity39 in KG-1 cell line. It was revealed that kefir decreased proliferation in @entity6007 cell line. We did not observe a remarkable effect of kefir on PBMCs. Our study suggested that kefir may have potential to be an effective treatment for @entity6007 .
