HLA genetics for diagnosis of susceptibility to early-onset XXXX .

@entity1 @entity2228 @entity2521 @entity1533 @entity2523
Human leukocyte antigens (HLA) are essential in the recognition of foreign antigens in humoral immune response, which is genetically predetermined. Susceptibility to certain diseases that involve the immune response has been studied in relation to distinct HLA types. Although some diseases have been found to correlate to specific HLA loci positively, it has been difficult to isolate HLA types that predispose @entity1 to periodontal destruction. Here, we review the current knowledge and recent advances in HLA genetics and its biology, which determine susceptibility to early-onset @entity2521 (EOP). The @entity1533 *1501-DQB1*0602 genotype has been found with increasing frequency in EOP @entity1 . This HLA genotype expresses aspartic acid at position 57 and @entity2228 at position 70 on the DQ beta chain, suggesting a capability to bind certain bacterial antigens. The T cell response against the outer membrane protein (Ag53) of @entity2523 was examined via this HLA genotype. Strong T cell response against Ag53 p141-161 was inhibited partially by anti-DR antibody, but not by anti-DQ antibody. Possible host and bacterial peptides capable of binding @entity1533 *1501 were elucidated when the peptide sequence was compared to gene and protein databases. These results suggest that @entity1 who have the @entity1533 *1501-DQB1*0602 genotype may have an accelerated T cell response to certain periodontopathic bacteria such as @entity2523 in hyperimmune reactions and thus increased susceptibility to EOP.
