[Another type of interaction between blood levels of digitalis and anti-arrhythmic drugs: @entity6838 and XXXX . Experience with long-term therapy].

@entity1 @entity2643 @entity137 @entity591 @entity6838 @entity3938
In clinical Arrhythmology it is often necessary to associate digitalis and antiarrhythmic agents. This calls for study of possible interaction between the employed drugs. We found a statistically significant correlation between digitalis and @entity2643 plasma level in @entity1 on long term treatment with both drugs. A statistically significant linear correlation between plasma @entity2643 level and @entity6838 (0.25 mg/day) or beta-methyldigoxin (0.20 mg/day) was documented in 33 @entity1 . 23 @entity1 had been treated with these drugs for paraxysmal reciprocating supraventricular @entity591 since an average of 52 months (computerized follow-up). ( @entity2643 average weekly dose was 1078 +/- 168 mg after a loading dose of 12 gm given over one month). 10 @entity1 were on chronic treatment with higher weekly doses of @entity2643 (average dose 2380 +/- 731 mg per week). Thyroid function tests (T4; @entity3938 ; T3UP; TSH; @entity3938 ) were checked in every @entity1 . Further studies are warranted to understand the mechanism of the interaction between @entity2643 and digitalis. As a clinical implication we point out that @entity2643 - @entity6838 (or betamethyldigoxin) interaction in our @entity1 has neither resulted in over-therapeutic plasma level nor in signs of @entity137 .
