Clinical Experience with Pulse Dose Rate Brachytherapy for Conservative Treatment of XXXX and Comparison with Historical Data of Low Dose Rate Brachytherapy.

@entity1 @entity137 @entity5 @entity957 @entity1066 @entity189 @entity3 @entity17539
AIMS: To assess the efficacy of pulse dose rate (PDR) interstitial brachytherapy in the treatment of @entity189 and to compare with historical data of low dose rate (LDR) brachytherapy. MATERIALS AND METHODS: We reviewed the clinical records of 27 consecutive @entity1 treated in our institution with exclusive PDR brachytherapy for a @entity957 . The median @entity5 greatest diameter was 20  mm (range: 10-50  mm). Twenty-three @entity1 (85%) had @entity5 limited to the glans and/or prepuce and four @entity1 (15%) also had inguinal lymph node @entity3 . Implantations were carried out according to the Paris system and treatments were delivered with PDR brachytherapy. RESULTS: The median brachytherapy dose was 60  Gy (range: 60-70  Gy). The median treated volume was 28  cm(3) (range: 8-62  cm(3)). The median reference isodose rate was 0.4  Gy/pulse/h (range: 0.4-0.5  Gy/pulse/h). The median number of pulses was 150 (range: 120-175 pulses). With a median follow-up of 33 months (range: 6-64 months), @entity5 relapses in the penis were reported in four @entity1 (15%). All @entity1 with only local relapse (n  =  3) were successfully salvaged with partial amputation. The estimated overall survival rate at 3 years was 95% (95% confidence interval: 83-100%). No grade 3 or more acute reaction was observed. Delayed @entity1066 and stenoses requiring at least one meatal dilatation were reported in two (9%) and five (22%) @entity1 without local relapse. The treated volume was significantly correlated to the risk of clinically relevant delayed @entity137 . CONCLUSIONS: The efficacy/ @entity137 results of PDR brachytherapy for the treatment of @entity17539 are comparable with those obtained with LDR brachytherapy in historical cohorts.
