Effects of long-term @entity503 administration on the natural history of @entity449 in XXXX .

@entity6970 @entity20616 @entity121 @entity449 @entity19 @entity15395 @entity439 @entity715 @entity503 @entity1028
UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity19 @entity1028 ( @entity1028 ). @entity6970 (-/-) @entity19 were implanted with saline- or @entity15395 ( @entity15395 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity503 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity15395 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity715 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity15395 compared with 46.2% for @entity15395 + CQ; P = NS) and categorical distribution of @entity439 . The markedly reduced survival rate observed with @entity15395 (57.1% for @entity15395 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity15395 + CQ; P = NS compared with @entity15395 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity15395 compared with 1.97    0.21 mm for @entity15395 + CQ; P = NS). @entity20616 fragmentation, collagen accumulation, and smooth @entity121 , which were higher in @entity15395 -treated @entity19 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity1028 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity449 . Manipulation of autophagy as a mechanism to reduce @entity1028 may need re-evaluation.
