@entity6701 nanoparticles promote @entity943 via a direct interaction with XXXX cardiac tissue.

@entity1 @entity32 @entity825 @entity73 @entity65 @entity6701 @entity35 @entity943 @entity3759
BACKGROUND: In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and @entity65 . Nanoparticles <50  nm in size are known to pass the alveolar-pulmonary barrier, enter into bloodstream and induce @entity32 , but the direct pathogenic mechanisms still need to be evaluated. We thus focused our attention on @entity6701 ( @entity3759 ) nanoparticles, the most diffuse nanomaterial in polluted environments and one generally considered inert for the @entity1 body. METHODS: We conducted functional studies on isolated adult @entity35 cardiomyocytes exposed acutely in vitro to @entity3759 and on healthy @entity35 administered a single dose of 2  mg/Kg @entity3759 NPs via the @entity825 . Transmission electron microscopy was used to verify the actual presence of @entity3759 nanoparticles within cardiac tissue, toxicological assays were used to assess lipid peroxidation and DNA tissue damage, and an in silico method was used to model the effect on action potential. RESULTS: Ventricular myocytes exposed in vitro to @entity3759 had significantly reduced action potential duration, @entity73 and decreased stability of resting membrane potential. In vivo, a single intra-tracheal administration of saline solution containing @entity3759 nanoparticles increased cardiac conduction velocity and tissue excitability, resulting in an enhanced propensity for inducible @entity943 . Computational modeling of ventricular action potential indicated that a membrane leakage could account for the nanoparticle-induced effects measured on real cardiomyocytes. CONCLUSIONS: Acute exposure to @entity3759 nanoparticles acutely alters cardiac excitability and increases the likelihood of arrhythmic events.
