Comparison of antibiotic-only and antibiotic- @entity134 combination treatment in corneal XXXX @entity1 : double-blinded randomized clinical trial.

@entity1 @entity7046 @entity1066 @entity619 @entity134 @entity3283 @entity230
OBJECTIVE: To determine the benefit of early addition of corticosteroids to antibiotics in the treatment of @entity3283 . DESIGN: Randomized clinical trial. @entity1 : Thirty eyes of 30 @entity1 , over the age of 12 years, with @entity3283 confirmed by culture. METHODS: @entity1 were randomized before enrollment; 15 were treated with @entity7046 (Zymar) and a masked placebo and the other 15 were treated with @entity7046 and masked @entity619 0.1% (Maxidex). Primary outcome was residual @entity1066 size at 10 weeks based on digital photographs. Secondary outcomes included residual @entity1066 area by clinician estimate, visual acuity, VF-14 score, and time to healing. RESULTS: All subjects (n = 30) demonstrated a reduction in @entity1066 size over the study period. There was no significant difference between the 2 groups in terms of the primary outcome. There was a significant difference between the 2 groups in 1 of the secondary outcomes. The mean residual @entity1066 size compared with the baseline by clinician estimate (slit-lamp) was -0.789 mm2 for the antibiotic-only group and -4.206 mm2 for the antibiotic- @entity134 group (p = 0.05). Among the other secondary outcomes there were no significant differences between the 2 groups. CONCLUSIONS: No benefit was demonstrated in our primary outcome for using @entity230 in combination with antibiotic therapy in treatment of @entity3283 . This study suggests that the early addition of @entity230 to the antibiotic treatment of @entity3283 does not seem to be harmful when employed in a closely monitored clinical setting.
