@entity10431 receptor and soluble matrix metalloproteinase-9 in @entity3052 XXXX : a possible relation to disease invasion.

@entity1 @entity10431 @entity706 @entity5 @entity3052 @entity1495 @entity2290
Extracellular proteolytic enzymes of the urokinase-type plasminogen activator ( @entity2290 ) and metalloproteinase (MMP) family play a crucial role in the matrix degradation and tissue remodeling process characteristic of @entity5 . The receptor for @entity10431 ( @entity10431 ) serves to localize and intensify the action of @entity2290 and is expressed on the surface of malignant cells. Although the biological significance of @entity1495 and soluble urokinase receptor in growth and progression of @entity706 is understood, its clinical significance in @entity3052 ( @entity3052 ) has not been fully elucidated. In this study, we determined the levels of soluble urokinase-type plasminogen activator receptor (suPAR), cellular @entity10431 and sMMP-9 in 43 newly diagnosed @entity3052 @entity1 at diagnosis, before chemotherapy, and also studied 10 normal subjects served as a control group. After chemotherapy suPAR and @entity1495 were determined at remission and relapse. The levels of suPAR, cellular PAR were significantly higher (P= 0.001, 0.001) and @entity1495 was significantly lower (P=0.001) in @entity3052 @entity1 at diagnosis as compared to controls. suPAR and @entity1495 levels were significantly lower in @entity3052 @entity1 who achieved complete remission (CR) as compared to those who did not (P= 0.001 for both). Levels of suPAR and @entity1495 were significantly correlated to peripheral blood blast cells (r= 0.88, P= 0.001; r= 0.65, P= 0.001, respectively) and blast cell distribution ratio (BCDR, r= 0.84, P= 0.001; r=65, P= 0.001, respectively). suPAR, cellular PAR and @entity1495 were significantly higher in @entity1 with extramedullary infiltration as compared with those without (P= 0.001, 0.001, <0.05). The suPAR, cellular @entity10431 , and @entity1495 levels were uneven in @entity3052 FAB subtypes being highest in M5(P<0.05 for all). @entity1495 and suPAR levels were correlated with the disease status. In @entity3052 survivors, @entity1495 , cellular @entity10431 and suPAR were significantly lower as compared to non-survivors (P= 0.001 for all). In conclusion, @entity1495 and su PAR levels might be used as a marker for disease activity and may contribute to blast cell dissemination. @entity1495 and suPAR may be target molecules in the strategy of treatment of @entity3052 .
