Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of @entity1 with resected XXXX .

@entity5 @entity1 @entity788 @entity660
OBJECTIVE: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of @entity5 cell dissemination along the needle track has limited its use. We hypothesised that if @entity5 cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of @entity1 with resected @entity788 . DESIGN: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified @entity1 with locoregional @entity788 who underwent curative intent surgery from 1998 to 2009. The @entity1 who received EUS-FNA within the peridiagnostic period were included in the EUS-FNA group. @entity1 who did not receive EUS evaluation or who underwent EUS without FNA were included in the non-EUS-FNA group. Overall survival and @entity788 -specific survival were compared after controlling for relevant covariates. RESULTS: A total of 2034 @entity1 with @entity788 were included (90% @entity788 ). Of these, 498 (24%) @entity1 were in EUS-FNA group. @entity1 with multiple comorbidities and more recent diagnosis were more likely to receive EUS-FNA. In multivariate analysis, after controlling for age, race, gender, @entity5 histology, @entity5 stage, @entity5 grade, @entity5 location, SEER site, year of diagnosis, undergoing percutaneous aspiration/biopsy, Charlson Comorbidity Index, radiation and chemotherapy, EUS-FNA was marginally associated with improved overall survival (HR 0.84, 95% CI 0.72 to 0.99), but did not affect @entity5 -specific survival (HR 0.87, 95% CI 0.74 to 1.03). CONCLUSIONS: Preoperative EUS-FNA was not associated with increased risk of mortality. These data suggest that EUS-FNA can be safely performed for the work-up of suspicious @entity660 .
