Measurement of serum XXXX phosphorylase levels by highly sensitive enzyme-linked immunosorbent assay in @entity356 .

@entity1 @entity5 @entity1014 @entity356 @entity1487
@entity1014 phosphorylase (TP) is an enzyme that converts 5'-DFUR to @entity1487 and also acts as an angiogenic factor. Measurement of serum TP levels has recently become possible by highly sensitive enzyme-linked immunosorbent assay (ELISA). We examined 38 @entity1 with @entity356 to measure serum TP levels by highly sensitive ELISA method and tissue TP levels by conventional ELISA. In addition, immunohistochemical staining of normal and @entity5 tissues was also performed. Serum TP levels in @entity1 with stages III and IV and inoperable or recurrent @entity5 were significantly higher than those in healthy controls. A high correlation was found between serum TP levels and @entity5 TP levels (r=0.65, p<0.0001). Moreover, serum TP levels were about 1/2500 of @entity5 TP levels. Tissue TP values in @entity5 were significantly higher than those in normal tissue. On the other hand, no significant differences among the @entity5 stages were found in either serum or @entity5 tissue. In conclusion, we demonstrate that serum TP levels strongly reflect @entity5 TP levels, and it may predict clinicopathological factors, prognosis, or sensitivity of anti- @entity5 drugs.
