XXXX is involved in the pathogenesis of cutaneous lichen planus.

@entity1 @entity32 @entity9338 @entity18297
BACKGROUND: @entity9338 ( @entity9338 ) is a chronic inflammatory and immune-mediated disease. @entity18297 is one of the most extensively studied Wnt proteins, and has important functions in stimulating @entity32 , cell proliferation, cell fate determination and cell differentiation. @entity18297 expression in @entity9338 has not been comprehensively studied to date. AIM: To determine the expression and distribution of @entity18297 in @entity9338 . METHODS: Skin samples were obtained from @entity1 with @entity9338 and healthy controls (HCs). The @entity18297 gene was detected by real-time quantitative PCR, and @entity18297 protein by immunohistochemical analysis and western blotting. RESULTS: @entity18297 mRNA was upregulated in @entity9338 samples compared with the HC skin samples (P  <  0.001). @entity18297 protein was overexpressed in all layers of the epidermis and dermis in @entity9338 compared with HC skin (all P  <  0.001). These results were confirmed by western blotting. CONCLUSIONS: The data presented in this study suggest that @entity18297 pathway may play an important role in the pathogenesis of @entity9338 .
