The histogenesis of DMH-induced @entity694 in XXXX .

@entity5 @entity18399 @entity35 @entity2513 @entity694 @entity20132
Twenty-one Donryu male @entity35 of six weeks old were injected with @entity20132 ( @entity18399 ), once a week, for 4 to 20 weeks, and sacrificed at intervals of two weeks since a lapse of four weeks after the commencement of the injections. The DMH induced 320 atypia lesions, from 0.03 through 20 mm in size, of grade II or higher. The rate of benign lesions was higher in the group receiving less than 20 injections than in the group of 20 injections of DMH, while in the latter group, the rates of the benign, borderline and malignant lesions were stable, suggesting that benign lesions mainly develop in the earlier period of the DMH treatment, and thereafter various grades of lesions develop at a constant rate. All the benign lesions were less than 1 mm in size, and all lesions greater than 1 mm were malignant. In addition, the size of the lesion was significantly greater when it was occupied by malignant crypts in a greater rate. These results indicate that the benign lesions become cancerous before they reach a certain size ( @entity2513 sequence). Twenty-seven minute lesions (less than 1 mm) were mixed lesions of malignant and benign atypia, suggesting that the @entity2513 sequence is elicited in any size of lesion. On the other hand, there were 41 minute @entity5 , which constituted 27.7% of the overall minute lesions and included three "single crypt" @entity5 . In addition, @entity5 were smaller when compared to the malignant-dominant mixed lesions. These results indicate that about 30% of @entity694 develop de-novo.
