Regular exercise decreases liver tumors development in hepatocyte-specific @entity2370 -deficient @entity19 independently of XXXX .

@entity1 @entity1560 @entity19 @entity5 @entity7936 @entity2370 @entity3470 @entity1561 @entity157
BACKGROUND _ AIMS: Unhealthy lifestyles predispose to @entity7936 ( @entity7936 ), which may further result in the development of @entity157 ( @entity157 ). Although @entity7936 @entity1 benefit from physical activity, it is unknown whether regular exercise reduces the risk of developing @entity157 . Therefore, we studied the effect of regular exercise on the development of @entity157 in male hepatocyte-specific @entity2370 -deficient @entity19 (AlbCrePten(flox/flox)), which develop @entity1560 and @entity157 spontaneously. METHODS: @entity19 were fed a standardized 10% fat diet and were randomly divided into exercise or sedentary groups. The exercise group ran on a motorized treadmill for 60 minutes/day, 5 days/week during 32 weeks. RESULTS: After 32 weeks of regular exercise, 71% of exercised @entity19 developed nodules larger than 15 mm(3) vs 100% of @entity19 in the sedentary group. The mean number of @entity5 per liver was reduced by exercise, as well as the total tumoral volume per liver. Exercise did not affect @entity1560 and had no effect on the @entity1561 ( @entity1561 ) Activity Score (NAS). Exercise decreased @entity5 cell proliferation. Mechanistically, exercise stimulated the phosphorylation of AMPK and its substrate raptor, which decreased the kinase activity of @entity3470 . CONCLUSIONS: These data show a benefit of regular exercise on the development of @entity157 in an experimental model of @entity7936 and offer a rationale for encouraging predisposed @entity1 to increase their physical activity for the prevention of @entity157 .
