High risk of subsequent @entity5 continues with extended follow-up of childhood XXXX : report from the Late Effects Study Group.

@entity1 @entity0 @entity2785 @entity3478 @entity5 @entity2 @entity978 @entity259 @entity356
PURPOSE: We present an update of a previously reported Late Effects Study Group cohort of 1,380 @entity1 with @entity978 ( @entity978 ) diagnosed between 1955 and 1986 in @entity1 aged 16 years or younger. We describe the pattern and incidence of subsequent @entity5 (SNs) occurring with extended follow-up. @entity1 AND METHODS: Median age at diagnosis of @entity978 was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years. RESULTS: An additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [ @entity259 ], 18.5, 95% CI, 15.6 to 21.7). The cumulative incidence of any second @entity5 was 10.6% at 20 years, increasing to 26.3% at 30 years; and of solid @entity5 was 7.3% at 20 years, increasing to 23.5% at 30 years. @entity0 was the most common solid @entity5 ( @entity259 , 56.7). Other commonly occurring @entity259 ( @entity259 , 36.4), @entity3478 ( @entity259 , 37.1), and colorectal ( @entity259 , 36.4), lung ( @entity259 , 27.3), and @entity356 ( @entity259 , 63.9). Risk factors for solid @entity5 included young age at @entity978 and radiation-based therapy. Thirty-two @entity1 developed third @entity5 , with the cumulative incidence approaching 21% at 10 years from diagnosis of second @entity5 . CONCLUSION: Additional follow-up of this large cohort of @entity978 survivors documents an increasing occurrence of known radiation-associated solid @entity5 , ( @entity0 ), as well as emergence of @entity2785 common in adults, ( @entity2 ) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.
