Anticoagulants and experimental XXXX -evaluation of antimetastatic effects in different model systems.

@entity3924 @entity5 @entity19 @entity1524 @entity2 @entity1003 @entity3 @entity320
Intravenous @entity5 cell injection and spontaneously metastasising transplantable @entity5 have been used as models for @entity5 spread. To evaluate the validity of these two experimental approaches for the study of @entity1003 and @entity3 , the effect of anticoagulants on "secondary" @entity5 growth was investigated in both models and the results were compared. The B16 @entity320 and the @entity2 in C57BL @entity19 were employed throughout the study, and anticoagulation was rendered through the use of phenprocoumon, heparin and ancrod. All anticoagulants were capable of reducing lung colonies after i.v. @entity5 cell injection, whereas only @entity3924 significantly diminished the formation of spontaneous @entity3 . A review of the current literature on anticoagulants and @entity5 dissemination and the observations described lead to the following conclusions: (1) Results from studies with i.v. introduced @entity5 cells cannot be extrapolated to spontaneously metastasising @entity5 . (2) Spontaneously metastasising @entity5 represent the preferable model for the study of antimetastatic effects of anticoagulants. (3) Little evidence exists to support the concept of the pathogenetic role of fibrin formation in the establishment of spontaneous @entity3 from blood-borne @entity5 cells. (4) @entity1524 derivatives are potent antimetastatic drugs, their mode of action appears to be independent of their anticoagulant activity.
