Very low-density lipoprotein-apoprotein CI is increased in XXXX : comparison with apoprotein CIII.

@entity2298 @entity1 @entity8 @entity644 @entity6 @entity301 @entity2316 @entity2299 @entity7964 @entity177
BACKGROUND: Recent studies have suggested that apoprotein (apo) CI in very low-density lipoprotein (VLDL) plays an important role in causing @entity2298 independent of apo CIII, which is associated with @entity301 ( @entity301 ). Because the incidence of @entity301 is increased in @entity6 @entity1 and is even higher when @entity2316 is developed, we measured apo CI levels in VLDL from type 2 @entity6 @entity1 , with various degree of @entity8 , and compared the results with those for healthy controls or @entity7964 @entity1 with @entity177 ( @entity177 ). METHODS: This study enrolled healthy control subjects, type 2 @entity6 @entity1 with normoalbuminuria, microalbuminuria, overt @entity644 , and @entity177 on hemodialysis and @entity7964 hemodialysis @entity1 . VLDL (density <1.006) was separated by ultracentrifugation. Then the apo CI, CIII, and B concentrations in VLDL were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The apo CI, CIII, and B concentrations in VLDL were respectively 3-, 2-, and 2-fold higher, respectively, in @entity6 @entity1 with overt @entity644 than in controls. Hemodialysis @entity1 with @entity2316 had levels of apo CI, CIII, and B in VLDL that were 2.6-, 2.7- and 2-fold higher, respectively, than those in controls. @entity7964 @entity1 also had a 2.7-fold higher level of VLDL apo CIII, whereas VLDL apo CI and VLDL apo B were not significantly increased. VLDL apo CI was significantly correlated with VLDL apo B independently of VLDL apo CIII level. CONCLUSION: An increase of VLDL apo CIII is a prominent feature of @entity2299 in @entity177 @entity1 , regardless of whether they are @entity6 or @entity7964 , whereas an increase of VLDL apo CI is more specific to @entity2316 and is closely associated with an increase of VLDL particle numbers, a new risk factor for @entity301 .
