XXXX of @entity1468 / @entity3036 : a systematic review and meta-analyses.

@entity1 @entity66 @entity3657 @entity3036 @entity1468 @entity299 @entity65
BACKGROUND: Preeclampsia affects 3% to 5% of gestations and @entity3036 0.05% to 0.93%, but their subsequent cardiovascular sequelae are unclear. The aim of this study was to determine if @entity1 with a history of @entity1468 / @entity3036 are at increased risk of long-term cardiovascular sequelae. METHODS: From Medline and Embase searches, we included case-control and cohort studies that examined cardiac, @entity3657 , or @entity65 >6 weeks postpartum, in @entity1 with and without a history of @entity1468 / @entity3036 and that controlled for or matched for confounders. Two independent reviewers determined study eligibility and extracted data. RESULTS: Five case-control and 10 cohort studies met eligibility criteria, with a total of 116,175 @entity1 with and 2,259,576 @entity1 without @entity1468 / @entity3036 . Most studies focused on @entity1 <56 years of age. Relative to @entity1 with uncomplicated pregnancies, @entity1 with a history of @entity1468 / @entity3036 had an increased risk of subsequent @entity299 in both the case-control studies (odds ratio 2.47, 95% CI 1.22-5.01) and the cohort studies (relative risk [RR] 2.33, 1.95-2.78), as well as an increased risk of @entity66 (RR 2.03, 1.54-2.67), @entity3657 (RR 1.87, 0.94-3.73), and @entity65 (RR 2.29, 1.73-3.04). Meta-regression revealed a graded relationship between the severity of @entity1468 / @entity3036 and the risk of @entity299 (mild: RR 2.00, 1.83-2.19, moderate: RR 2.99, 2.51-3.58, severe: RR 5.36, 3.96-7.27, P<.0001). CONCLUSIONS: @entity1 with a history of @entity1468 / @entity3036 have approximately double the risk of early cardiac, cerebrovascular, and @entity3657 , and @entity65 . Further research is needed to determine the mechanisms underlying these associations and to identify effective prevention strategies.
