Root of Polygonum cuspidatum extract reduces progression of @entity2316 via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in XXXX -induced @entity6 @entity35 .

@entity1 @entity6 @entity2316 @entity11240 @entity3839 @entity1918 @entity633 @entity1975 @entity35 @entity7622 @entity4854 @entity413
BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is highly expressed in the renal tissues of @entity1 with @entity2316 , and it plays an important role in the initiation and progression of @entity2316 . The aim of this study was to evaluate the protective effects of root of Polygonum cuspidatum extract ( @entity11240 ) on early renal glomerular proliferation in @entity3839 (STZ)-induced @entity6 @entity35 . METHODS: @entity11240 (100, 350 mg/kg/day) was administered to @entity6 @entity35 for 16 weeks. Blood @entity413 and @entity633 were measured. Renal histology, @entity1918 ( @entity1918 ), and @entity1975 ( @entity1975 ) expression levels were also examined. RESULTS: After 16 weeks of treatment with @entity11240 , severe @entity4854 and @entity633 were observed in the @entity6 @entity35 . The expressions levels of @entity1918 and @entity1975 proteins were significantly increased in the glomeruli of the @entity6 @entity35 . The expression levels of PDGF-BB and its receptor expressions were greatly increased in the glomeruli of the @entity6 @entity35 . However, @entity11240 markedly reduced @entity633 in the @entity6 @entity35 . @entity11240 inhibited @entity1918 and @entity1975 up-regulation and ameliorated PDGF-BB and PEGFR-Ss protein expression in the @entity6 @entity35 . In addition, the binding of PDGF-BB/PDGFR-Ss was inhibited by @entity11240 as shown by an in vitro assay. CONCLUSIONS: These results suggest that @entity11240 has an inhibitory effect on @entity7622 in @entity2316 via the inhibition of the interaction of PDGF-BB with its receptor. @entity11240 may have beneficial effects in preventing the progression of @entity2316 .
