Enhancement of XXXX with contralateral hand activation.

@entity1 @entity1726 @entity2003
OBJECTIVE: Quantify the enhancement of @entity2003 associated with a contralateral activation maneuver. METHODS: Twelve subjects with @entity1726 and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60   without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with @entity1726 were tested in both OFF-MED and ON-MED states. @entity2003 was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on @entity2003 . RESULTS: @entity1726 @entity1 had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p=0.002). Medication substantially reduced differences in torque resistance between controls and @entity1726 @entity1 in the Passive and Active conditions. CONCLUSIONS: A contralateral activation maneuver substantially increases @entity2003 in @entity1 with @entity1726 , specifically the OFF-MED state. @entity2003 is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. SIGNIFICANCE: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of @entity1726 .
