Recurrent miscarriage is associated with a family history of XXXX : a retrospective cohort study.

@entity1 @entity2208 @entity66 @entity299 @entity1211 @entity65
OBJECTIVE: To determine whether @entity1 experiencing recurrent miscarriage were more likely to have a family history of @entity65 . DESIGN: Retrospective cohort study. SETTING: @entity1 having a first birth in Scotland between 1992 and 2006. SAMPLE: A total of 74, 730 first births were linked to the hospital admission and death certification data for the @entity1 's parents through the @entity1 's birth certificates. METHODS: The incidence of @entity65 in the @entity1 's parents was related to the number of @entity2208 experienced before their daughters' first births using a Cox proportional hazards model. MAIN OUTCOME MEASURES: Death or hospital admission of the @entity1 's parents for @entity299 ( @entity299 ), @entity66 ( @entity66 ) or @entity1211 ( @entity1211 ). MAIN RESULTS: There was an increased incidence of @entity299 in the parents of @entity1 who experienced two @entity2208 before their first birth (hazard ratio 1.25, 95% CI 1.04-1.49) and parents of @entity1 who experienced three or more @entity2208 before their first birth (hazard ratio 1.56, 95% CI 1.14-2.15). Adjustment for the characteristics of the @entity1 at the time of the first birth was without material effect. There was no significant association between miscarriage and family history of @entity66 or @entity1211 . There was no significant association between the number of therapeutic terminations of pregnancy before the first birth and the incidence of any type of @entity65 in the @entity1 's parents. CONCLUSIONS: The parents of @entity1 who experience recurrent miscarriage are more likely to experience @entity299 . Recurrent miscarriage and @entity299 may have common patho-physiological pathways and genetic predispositions.
