Lower extremity strength, systemic XXXX and all-cause mortality: Application to the "fat but fit" paradigm using cross-sectional and longitudinal designs.

@entity1 @entity32 @entity28 @entity1851
BACKGROUND: No study has applied the "fat-but-fit" paradigm with respect to muscular strength as an index of fitness, despite muscular strength being independently associated with functional ability and mortality. PURPOSE: To examine the relationship between lower extremity muscular strength, @entity1851 ( @entity1851 ), and all-cause mortality among normal weight, overweight and @entity28 individuals. METHODS: Data from the 1999-2002 NHANES were used (N=2740 adults; >= 50years). @entity1851 values were obtained from a blood sample. Lower body isokinetic knee extensor strength (IKES) was assessed using a Kin Kom MP isokinetic dynamometer. @entity1 data was linked to death certificate data from the National Death Index to ascertain all-cause mortality status. @entity1 were classified, based on body mass index (BMI) and strength as: normal weight and unfit (<75th IKES percentile); overweight and unfit; @entity28 and unfit: normal weight and fit (>= 75th IKES percentile); overweight and fit; and @entity28 and fit. RESULTS: Independent of physical activity and other confounders, compared to those who were normal weight and unfit, unfit overweight (b=.14, p=0.009), unfit @entity28 (b=.33, p<0.001), and @entity28 and fit (b=.17, p=0.008) @entity1 , had higher @entity1851 levels. However, there was no difference in @entity1851 levels between normal weight and unfit @entity1 and overweight and fit @entity1 (b=0.04, p=0.35). Compared to normal weight unfit adults, overweight fit (HR=0.28; 95% CI: 0.11-0.70; p=0.008) adults had a lower hazard rate for all-cause mortality. CONCLUSIONS: These finding suggest that increased lower body strength, independent of physical activity, may reduce premature all-cause mortality and attenuate systemic @entity32 among overweight adults.
