Health related quality of life in adolescent and young adult survivors of lower extremity XXXX .

@entity1 @entity860 @entity3478 @entity4218 @entity717
BACKGROUND: Dramatic increases in survival rates have led to increased interest regarding the health related quality of life (HRQOL) of adolescent and young adult survivors of @entity3478 . This study investigated HRQOL and @entity717 in adolescent and young adult survivors of lower extremity @entity3478 as a function of type of surgical intervention, gender, and age at assessment. PROCEDURE: Twenty-eight @entity1 (age range 18-32 years) completed three generic and one disease-specific measures of HRQOL and a measure of @entity717 . For analysis, surgical intervention was grouped into @entity4218 ( @entity4218 ; allograft fusion and endoprosthesis) and ablative surgeries ( @entity860 ; amputation or Van Nes rotationplasty). Age at study was grouped into  <= 25 years of age and >=  26 years of age. The MOS-SF-36, HUI2, HUI3, and EORTC-QLQ-C30 were used to measure HRQOL and the TESS was used to assess @entity717 . RESULTS: Survivors reported HRQOL equivalent to the general population, with the exception of physical functioning. @entity4218 reported poorer HRQOL than AMP @entity1 for emotional functioning and fatigue. Males reported better HRQOL compared with females for overall HRQOL, general health, physical functioning, and social functioning. Finally, younger @entity1 generally reported better HRQOL than older @entity1 for overall HRQOL and physical functioning. CONCLUSIONS: This study identifies @entity4218 surgical intervention, female gender and older age as risk factors for reduced HRQOL in adolescent and young adult survivors of lower extremity @entity3478 . This study also provides information about what instrument may be most useful in identifying these specific difficulties and subgroups.
