XXXX with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties.

@entity1 @entity295 @entity2176 @entity1423 @entity303 @entity114 @entity1686 @entity3524 @entity281 @entity2259 @entity884
BACKGROUND: Since Aerococcus sanguinicola was designated as a species in 2001, only a few cases of @entity2259 have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola @entity2259 and to determine the antibiotic susceptibility and the capacity of the bacteria to form biofilm and to induce @entity1423 . METHODS: Isolates of A sanguinicola from blood cultures were retrospectively identified from 2 clinical microbiology laboratories for 2006 to 2012. Species identity was confirmed through sequencing of the 16S rRNA gene. The medical charts of @entity1 were reviewed. The minimum inhibitory concentration (MIC) for relevant antibiotics was determined. Biofilm formation was measured as the amount of @entity1686 absorbed. @entity1423 was determined by aggregometry. RESULTS: Eleven cases of A sanguinicola @entity2259 were identified. All @entity1 were male and the median age was 82 years (range 67-93). Nine @entity1 fulfilled criteria for severe @entity295 , and 2 @entity1 died at hospital. Two @entity1 were diagnosed with @entity884 . Most @entity1 had underlying urinary tract diseases or an indwelling urinary tract catheter. Five @entity1 suffered from @entity303 . None of the @entity1 was treated with immunosuppressive medications. The MIC values of the isolates were in line with previous reports, with low MICs for @entity114 , @entity3524 , and @entity2176 . All 11 isolates produced biofilms but not all could induce @entity1423 . CONCLUSIONS: A sanguinicola can cause severe @entity281 in elderly @entity1 with urinary tract abnormalities and the bacteria possess potential virulence mechanisms.
