Genome-wide scan for XXXX milk-fat composition. I. Quantitative trait loci for short- and medium-chain fatty acids.

@entity6221 @entity35924 @entity23398 @entity1718 @entity291 @entity24160
A genome-wide scan was performed to identify @entity23398 ( @entity23398 ) for short- and medium-chain @entity1718 (expressed in wt/wt %). Milk samples were available from 1,905 @entity291 from 398 commercial herds in the Netherlands, and milk-fat composition was measured by gas chromatography. DNA was available from 7 of the paternal half-sib families: 849 @entity291 and their 7 sires. A genetic map was constructed comprising 1,341 SNP and 2,829 cM, with an average information content of 0.83. Multimarker interval mapping was used in an across-family regression on corrected phenotypes for the 7 half-sib families. Four @entity23398 were found: on @entity291 autosome (BTA) 6, a @entity23398 was identified for C6:0 and C8:0; on BTA14, a @entity23398 was identified for fat percentage, all odd-chain @entity1718 , and C14:0, C16:0, C16:1, and their unsaturation indices; on BTA19, a @entity23398 affected C14:0; and on BTA26, a @entity23398 was identified for the @entity6221 and their unsaturation indices. The @entity23398 explained 3 to 19% of phenotypic variance. Furthermore, 49 traits with suggestive evidence for linkage were found on 21 chromosomes. Additional analyses revealed that the @entity23398 on BTA14 was most likely caused by a mutation in @entity24160 , whereas the @entity23398 on BTA26 was most likely caused by a mutation in the @entity35924 gene. Quantitative trait loci that affect specific @entity1718 might increase the understanding of physiological processes regarding fat synthesis and the position of the causal genes.
