Effect of antiretroviral therapy on hemoglobin A2 values can have implications in antenatal XXXX screening programs.

@entity1 @entity9611 @entity14027 @entity24194 @entity8674 @entity13554 @entity645 @entity11140 @entity15833 @entity4764 @entity2395
BACKGROUND: Raised @entity13554 ( @entity13554 ) is the diagnostic hallmark of @entity8674 trait (bTT). @entity4764 may arise in @entity645 -positive patients on antiretroviral therapy (ART). We compared the effect of various antiretroviral drugs on @entity13554 levels. We attempted to determine which drugs elevate @entity13554 levels causing a false-positive diagnosis of bTT and correlate the findings with red cell indices. METHODS: A retrospective analysis of the records of an antenatal @entity2395 screening program was carried out for 78 @entity645 -positive adults (70 antenatal @entity1 and 8 husbands) to study the effect of antiretroviral drugs on @entity13554 levels. Three had bTT; 20 treatment-na  ve subjects constituted controls. The effects of @entity9611 (36 cases), @entity14027 (7 cases), and @entity15833 (12 cases) were evaluated. High-performance liquid chromatography was done for @entity13554 levels. Values of 3.5-3.9% were borderline and   >=    4% with @entity24194 microcytosis was considered to be bTT. RESULTS: Twenty individuals not on ART had normal @entity13554 %. Three @entity1 had bTT and showed @entity24194 microcytosis despite being on @entity9611 . Fourteen of 55 @entity1 on treatment (25.5%) had borderline @entity13554 values (mean 3.7%): 11 were on a @entity9611 -based regimen and 3 on a @entity14027 -based regimen. One @entity1 on @entity9611 had 4.1% @entity13554 with normal Hb and severe @entity11140 (MCV 128.5 fl), leading to a false suspicion of bTT. All @entity1 on @entity15833 had normal @entity13554 . Hematological parameters, including mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and @entity13554 levels were increased due to antiretroviral drugs @entity9611 and @entity14027 . CONCLUSION: Treatment-na  ve subjects and those on @entity15833 showed no effect on @entity13554 levels compared with @entity9611 and @entity14027 . A proportion of @entity1 on @entity9611 or @entity14027 had borderline elevated @entity13554 levels, which could lead to a false impression of bTT.
