Endothelial expression of XXXX and @entity4725 is suppressed by postbypass plasma containing increased soluble @entity2071 and @entity4725 .

@entity1 @entity32 @entity4725 @entity1356 @entity4105 @entity2533 @entity2071 @entity67182 @entity687 @entity688 @entity1851
OBJECTIVE: Endothelial cell dysfunction has been implicated in the inflammatory response to cardiopulmonary bypass, and the upregulation of endothelial cell expression of adhesion molecules might promote leukocyte extravasation in vivo. Soluble endothelial cell adhesion molecules are increased after bypass. The aim of this study was to investigate the relationship between endothelial cell-surface expression of adhesion molecules and their concentration in plasma after coronary artery bypass grafting. METHODS: Ten @entity1 undergoing coronary artery bypass with cardiopulmonary bypass had 5 plasma samples taken at defined intervals before, during, and after cardiopulmonary bypass. Plasma was incubated with @entity1 umbilical vein endothelial cell monolayers, and expression of @entity4105 , @entity2071 , and @entity4725 on the surface of @entity1 umbilical vein endothelial cell monolayers was measured by means of enzyme-linked immunosorbent assay. Plasma soluble adhesion molecules, @entity1851 , @entity687 , @entity688 , @entity2533 , and neutrophil counts were determined for each @entity1 . RESULTS: Markers typical of acute @entity32 (ie, @entity687 , neutrophils, and @entity1851 ) were all increased after bypass. Soluble plasma intercellular and @entity4725 (but not @entity4105 ) were increased after bypass. However, endothelial cell expression of @entity67182 (but not @entity4105 ) were significantly decreased by exposure to postbypass plasma. Additionally, postbypass plasma inhibited @entity1356 -stimulated endothelial cell expression of vascular cell and @entity2071 . @entity688 and @entity2533 , both of which are known to inhibit endothelial cell adhesion molecule expression, were respectively increased 10-fold and 3-fold (P <.05) after bypass. CONCLUSIONS: Despite containing increased soluble intercellular and @entity4725 , postbypass plasma inhibits endothelial cell expression of intercellular and @entity4725 . Upregulated vascular expression of adhesion molecules might not be essential for endothelial activation after bypass.
