[Pharmacokinetics of XXXX derivatives].

@entity1 @entity9158 @entity13641
Pharmacokinetic properties of @entity9158 derivatives drug possessing antipsychotic, actoprotector, antiarrhythmic, antiulcerogenic, antiallergic, uricosuric, anthelmintic activities have been summarized. Pharmacokinetics of @entity9158 derivatives used in veterinary practice as anthelmintic drugs is also considered. @entity13641 derivatives are characterised by multicompartment and ambiguous pharmacokinetic models. The derivatives of @entity13641 are subjected to the first pass metabolism in the liver, and, therefore, they are converted to both active, and inactive metabolites. It is necessary to take into account for coadministration of @entity13641 with other drugs. Hepatoduodenal circulation and repeated adsorption of unchanged drug and its metabolites in the gut is observed for @entity9158 . Many derivatives of @entity13641 are characterised by rather low absolute bioavailability during peroral intake (from 2 up to 60%). Benzimidazsole derivative may bind to proteins and cell elements of blood. More often pharmacokinetic profile of @entity13641 is linear for low doses, however, at high doses the linearity is lost. For animals and @entity1 pharmacokinetic models are always nearly identical.
