Microtubule-associated tau protein positive neuronal and glial inclusions in XXXX .

@entity1 @entity8095 @entity527 @entity1423 @entity2655 @entity73 @entity3072 @entity1129 @entity746 @entity5515
BACKGROUND: The authors compared tau protein deposition in the frontal cortex of @entity1 with @entity73 of @entity746 ( @entity746 ) (n = 6), cognitively intact @entity1 with @entity2655 (n = 6), and age-matched controls (n = 6) in order to determine the pathologic substrate of @entity746 . METHODS: Archival paraffin-embedded tissue was examined using Gallyas staining and immunostaining for tau-1 (phosphorylation-dependent @entity3072 ), tau-2 (phosphorylation independent), @entity3072 ( @entity1129 8; ser(396) phosphorylation), beta-amyloid, glial fibrillary acid protein, SMI 31 (recognizing phosphorylated NFH), @entity8095 , or ubiquitin. RESULTS: Tau immunoreactive astrocytic and dense neuronal inclusions were found in both @entity2655 and @entity746 , although to a greater extent in @entity746 . @entity5515 and @entity1423 , immunoreactive with tau-1 and @entity1129 8 but rarely to ser(396) tau, were unique to @entity746 . Dense extracellular aggregates were observed by both Gallyas staining and tau-1 immunostaining. Tufted degenerating astrocytes containing tau-1 and @entity1129 8 immunoreactive aggregates and, rarely, dense @entity527 immunoreactive with tau-1 and @entity1129 8, but not with ser(396) tau or beta-amyloid, were observed in @entity746 . Tau positive glial coiled bodies were observed in the deep cortical layers and adjacent subcortical white matter in @entity746 . Although 3R and 4R tau mRNA isoforms were expressed to similar levels in the frontal cortex of all cases, the total amount of tau mRNA was increased in both @entity2655 and @entity746 . Both gray and white matter soluble tau protein expression was similar among control, @entity2655 , and @entity746 cases. CONCLUSIONS: @entity73 in @entity2655 may reflect abnormal tau protein metabolism.
