Overlap XXXX Is Associated with a Unique Gene Expression Pattern.

@entity32 @entity9707 @entity18123 @entity406 @entity5870 @entity102 @entity600 @entity12448 @entity14638 @entity67802 @entity373 @entity2731
Breakdown of the balance between maternal pro- and anti-inflammatory pathways is thought to allow an anti-fetal maternal immune response that underlies development of @entity32 . @entity32 is manifested by the influx of maternal inflammatory cells, including lymphocytes, histiocytes, and plasma cells, into the placental membranes, villi, and decidua. These infiltrates are recognized pathologically as chronic @entity5870 , @entity102 of unknown etiology, and chronic deciduitis. Each of these histological entities is associated with adverse fetal outcomes including intrauterine growth restriction and @entity600 . Studying the gene expression patterns in chronically inflamed placenta, particularly when overlapping histologies are present, may lead to a better understanding of the underlying mechanism(s). Therefore, this study compared tissue with and without @entity32 , manifested as overlapping chronic @entity5870 , @entity102 of unknown etiology, and chronic deciduitis. RNA expression profiling was conducted on @entity406 fixed, paraffin embedded placental tissue using Illumina microarrays. @entity18123 was the most significant differentially expressed gene identified and had increased expression in the inflamed tissue. In addition, @entity67802 , @entity14638 , @entity2731 , @entity373 , @entity12448 , and @entity9707 had increased expression in the inflamed placental samples. These differentially expressed genes are associated with T follicular helper cells, natural killer cells, and B cells. Furthermore, these genes differ from those typically associated with the individual components of @entity32 , such as @entity102 , suggesting that the inflammatory infiltrate associated with overlapping chronic @entity5870 , @entity102 of unknown etiology, and chronic deciduitis differs is unique. To further explore and validate gene expression findings, we conducted immunohistochemical assessment of protein level expression and demonstrate that @entity18123 expression was largely attributable to the presence of plasma cells as part of chronic deciduitis and that IgA positive plasma cells are associated with chronic deciduitis occurring in combination with chronic @entity5870 and @entity102 of unknown etiology but not with isolated chronic deciduitis.
