Global Estimates of the Prevalence and Incidence of Four Curable XXXX in 2012 Based on Systematic Review and Global Reporting.

@entity1 @entity281 @entity1047 @entity2953
BACKGROUND: Quantifying @entity2953 ( @entity2953 ) prevalence and incidence is important for planning interventions and advocating for resources. The World Health Organization (WHO) periodically estimates global and regional prevalence and incidence of four curable STIs: @entity1047 , gonorrhoea, trichomoniasis and syphilis. METHODS AND FINDINGS: WHO's 2012 estimates were based upon literature reviews of prevalence data from 2005 through 2012 among general populations for @entity281 with @entity1047 , gonorrhoea, and trichomoniasis, and nationally reported data on syphilis seroprevalence among antenatal care attendees. Data were standardized for laboratory test type, geography, age, and high risk subpopulations, and combined using a Bayesian meta-analytic approach. Regional incidence estimates were generated from prevalence estimates by adjusting for average duration of @entity281 . In 2012, among @entity1 aged 15-49 years, the estimated global prevalence of @entity1047 was 4.2% (95% uncertainty interval (UI): 3.7-4.7%), gonorrhoea 0.8% (0.6-1.0%), trichomoniasis 5.0% (4.0-6.4%), and syphilis 0.5% (0.4-0.6%); among @entity1 , estimated @entity1047 prevalence was 2.7% (2.0-3.6%), gonorrhoea 0.6% (0.4-0.9%), trichomoniasis 0.6% (0.4-0.8%), and syphilis 0.48% (0.3-0.7%). These figures correspond to an estimated 131 million new cases of @entity1047 (100-166 million), 78 million of gonorrhoea (53-110 million), 143 million of trichomoniasis (98-202 million), and 6 million of syphilis (4-8 million). Prevalence and incidence estimates varied by region and sex. CONCLUSIONS: Estimates of the global prevalence and incidence of @entity1047 , gonorrhoea, trichomoniasis, and syphilis in adult @entity1 and @entity1 remain high, with nearly one million new infections with curable @entity2953 each day. The estimates highlight the urgent need for the public health community to ensure that well-recognized effective interventions for @entity2953 prevention, screening, diagnosis, and treatment are made more widely available. Improved estimation methods are needed to allow use of more varied data and generation of estimates at the national level.
