Fertility of long-term male survivors of XXXX diagnosed during childhood.

@entity1 @entity981 @entity5 @entity73 @entity1778
@entity73 among @entity1 treated during childhood for @entity5 are known to occur after some, but not all, types of anti- @entity5 therapy. This is the first study to evaluate proven fertility among adult male survivors of childhood @entity981 ( @entity981 ). In a retrospective cohort study, proven fertility (ever fathered a pregnancy) was evaluated by self-report among 213 @entity1 treated for @entity981 before age 18 on protocols of the @entity1 's @entity5 Group (CCG). Controls (N = 145) were drawn from among male siblings. Overall, with a proportional hazards analysis, proven fertility of male survivors was not different from that of controls (relative fertility (RF) = 0.95, 95% CI 0.63-1.43). However, married @entity1 treated before age 10 with high dose (24 cGy) cranial radiotherapy (RT), without spinal RT, had only 9% of the fertility of controls (Relative risk, RR = 0.09, 95% CI 0.01-0.82). High dose cranial RT at older ages was not associated with a statistically significant fertility deficit (RR = 0.56, 95% CI 0.25-1.28). In this first study of proven fertility among @entity1 treated for @entity1778 , the majority of survivors showed no evidence of @entity73 compared to controls. However, @entity1 treated at a young age with high dose cranial RT may have impaired fertility. These results suggest that further investigation of @entity1 with these treatments is needed to confirm and extend these findings.
