Differential Susceptibility of XXXX Pleural and Peritoneal Mesothelial Cells to Asbestos Exposure.

@entity1 @entity32 @entity650 @entity1261 @entity1356 @entity5 @entity3620 @entity1192 @entity13465 @entity10149 @entity23638 @entity687 @entity105 @entity10150 @entity1355
UNASSIGNED: @entity3620 ( @entity3620 ) is an aggressive @entity5 of mesothelial cells of pleural and peritoneal cavities. In 85% of cases both @entity3620 is caused by @entity1355 exposure. Although both are @entity1355 -induced @entity5 , the incidence of @entity3620 is significantly higher (85%) than peritoneal @entity3620 (15%). It has been proposed that @entity105 is a result of @entity1355 -induced @entity32 but it is not clear what contributes to the differences observed between incidences of these two @entity5 . We hypothesize that the observed differences in incidences of @entity3620 are the result of differences in the direct response of these cell types to @entity1355 rather than to differences mediated by the in vivo microenvironment. To test this hypothesis we characterized cellular responses to @entity1355 in a controlled environment. We found significantly greater changes in genome-wide expression in response to @entity1355 exposure in pleural mesothelial cells as compared to peritoneal mesothelial cells. In particular, a greater response in many common genes ( @entity687 , @entity23638 , @entity10149 , @entity10150 , @entity650 , @entity1 ) was seen in pleural mesothelial cells as compared to peritoneal mesothelial cells. Unique genes expressed in pleural mesothelial cells were mainly pro-inflammatory ( @entity1261 , @entity1356 , @entity1192 , @entity13465 ) and have previously been shown to be involved in development of @entity3620 . Our results are consistent with the hypothesis that differences in incidences of @entity3620 upon exposure to @entity1355 are the result of differences in mesothelial cell physiology that lead to differences in the inflammatory response, which leads to @entity5 . J. Cell. Biochem. 116: 1540-1552, 2015.    2015 Wiley Periodicals, Inc.
