Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in XXXX .

@entity8 @entity6098 @entity2686 @entity7418 @entity7420 @entity35
UNASSIGNED: The aim of this study was to investigate the effects of @entity7418 ( @entity7418 ) and @entity7420 ( @entity7420 ) on bone marrow-derived stem cell (BMSC) mobilization in @entity35 models of @entity8 /reperfusion (I/R) injury. In addition, the effects of @entity7418 and @entity7420 on cellular apoptosis were explored in order to determine the protective mechanism of the two factors against @entity8 . A unilateral @entity8 model was established for the model and treatment groups. The treatment and treatment control groups were subcutaneously injected with @entity7418 (200   g/kg/day) and @entity7420 (50   g/kg/day) 24 h after the establishment of the model for five consecutive days. The total number of leukocytes in the peripheral blood and the cellular percentages of @entity2686 ( @entity2686 )34(+), renal @entity6098 (+) and apoptotic cells were detected. The total number of leukocytes in the peripheral blood and the percentages of @entity6098 (+) cells in the treatment and treatment control groups reached maximum levels on the fifth postoperative day and were significantly higher than those in the normal control and model groups. The number of renal @entity6098 (+) cells in the treatment group was significantly increased compared with that in the treatment control and model groups. The apoptotic indices (AIs) of the model and treatment groups were higher than those of the normal control and treatment control groups. The AI of the model group was significantly higher than that of the treatment group. In conclusion, the combined application of @entity7418 and @entity7420 can mobilize sufficient numbers of BMSCs and cause cellular 'homing' to the injured site, thus inhibiting apoptosis and promoting the repair of @entity8 .
