Risk Factors for Progression or Malignancy in Main-Duct and Mixed-Type XXXX .

@entity1 @entity788 @entity4929 @entity6 @entity5 @entity1157
OBJECTIVES: The 2012 international guidelines state that surgery should be considered for all surgically fit @entity1 with @entity788 ( @entity1157 )/mixed @entity4929 ( @entity4929 ). This study evaluated the follow-up results of @entity1157 /mixed @entity4929 and risk factors for progression or @entity5 . METHODS: @entity1 with @entity1157 /mixed @entity4929 were retrospectively enrolled and divided into surgical and nonsurgical groups. These 2 groups were compared and further categorized as progression/ @entity5 or not. In the nonsurgical group, disease progression was defined as radiologic @entity5 growth or adjacent organ invasion. RESULTS: Data from 101 @entity1 (73 males; mean [SD] age, 66.3   [9.1]   years), including 27 and 74 in the nonsurgical and surgical groups, respectively, were analyzed. Mural nodules were more frequently detected in the surgical group (7.4% vs 31.1%, P = 0.018), whereas more multifocal cysts were observed in the nonsurgical group (40.7% vs 20.3%, P = 0.037). Forty-one @entity1 (40.6%) showed progression or @entity5 . Multivariate analysis showed that main pancreatic duct of 10 mm or greater (odds ratio, 4.368; P = 0.024) and pre-existing @entity6 (odds ratio, 3.077; P = 0.046) were independent risk factors for progression or @entity5 . CONCLUSIONS: A watchful waiting strategy could be feasible for some @entity1 with @entity1157 /mixed @entity4929 , particularly those with a main pancreatic duct of less than 10 mm and without @entity6 .
