The physiopathological significance of XXXX : a study of 64 cases.

@entity1 @entity706 @entity2783 @entity1581 @entity8058 @entity1582 @entity8057
Sixty-four patients with monoclonal protein in serum but initially without evidence of @entity1582 , @entity8057 , @entity2783 or @entity706 , were studied. Fifty @entity1 (78%) were observed for a period of exceeding 3 years. Based on the follow-up data the @entity1 were classified into the following four groups: Group 1 = @entity1 with transient @entity1581 : 4 . 7%; Group 2 = @entity1 without significant increase in monoclonal serum protein: 75%; Group 3 = @entity1 with more than 50% increase in monoclonal serum protein: 14 . 1%; Group 4 = @entity1 in whom @entity1582 developed: 6 . 2%. The mean interval from discovery of the serum monoclonal protein to evolution to @entity1582 was 61 months. Retrospective analysis of age, sex, blood count, bone marrow picture, antigenic type and size of serum monoclonal proteins, presence of small amounts of homogeneous light chain in the urine, serum albumin level, levels of residual immunoglobulins, did not help to distinguish initially the @entity1 in whom the @entity1581 evolved to @entity1582 from @entity1 in whom the disease remained benign and stable. The evolution to @entity1582 had occurred abruptly after long periods of stable condition; and until this progression the follow-up data were similar to the @entity1 with benign disease. The possible physiopathology of occurrence and evolution of @entity8058 is discussed.
