Association of @entity148 Symptoms in Offspring of Bipolar Parents with XXXX Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype.

@entity1 @entity162 @entity148 @entity750
OBJECTIVE: Offspring of parents with @entity162 ( @entity162 ) have been shown to be at high risk for @entity162 . @entity148 , even at subclinical levels, have been associated with increased risk for @entity162 in these youth. The s-allele of the @entity750 transporter-linked polymorphic region (5-HTTLPR) has been implicated in the pathophysiology of both @entity162 and @entity148 and has been associated with pharmacological treatment response and increased risk for antidepressant side effects. Therefore, we aimed to explore 1) whether @entity148 in offspring of @entity162 parents were associated with presence of the 5-HTTLPR s-allele and 2) whether @entity148 in the offspring of @entity162 parents according to the 5-HTTLPR genotypes are related to antianxiety medication status. METHODS: A total of 64 offspring of @entity162 parents (mean age: 13.7 years) and 51 healthy controls (HC) (mean age: 13.7 years) were compared genetically and on the Multidimensional @entity148 Scale for @entity1 (MASC). RESULTS: Offspring of @entity162 parents showed higher levels of overall @entity148 than did the HC group. Only antianxiety medication na  ve offspring of @entity162 parents were found to have an association between 5-HTTLPR genotypes and @entity148 . The antianxiety medication na  ve offspring of @entity162 parents with the s-allele showed higher level of overall @entity148 than offspring of @entity162 parents with the l/l genotype. No significant differences in @entity148 or their association with the 5-HTTLPR genotype were found in the HC group. CONCLUSIONS: This study indicated that there may be an association between 5-HTTLPR genotypes and @entity148 in offspring of @entity162 parents, and that antianxiety medication status may affect @entity148 in the offspring of @entity162 @entity1 according to genotype.
