Treatment with various antibiotics of experimental @entity884 caused by XXXX -resistant @entity885 .

@entity1 @entity801 @entity2892 @entity2176 @entity114 @entity95 @entity885 @entity2886 @entity11248 @entity204 @entity3402 @entity884
BACKGROUND: @entity885 currently accounts for one-half of viridans streptococci. Treatment has become complicated due to the increase in resistance to @entity114 and @entity2886 . The aim of the study was to assess the efficacy of various antibiotics as monotherapy and in association with @entity801 , in a experimental model of @entity884 in @entity95 . The effects were compared with a control group and a group given classical @entity114 - @entity801 treatment. MATERIAL AND METHODS: @entity884 was induced in 180 @entity95 with a clinical isolate of @entity885 . Treatment was started 48 h after infection, and lasted 5 days. The animals were divided into nine groups of 20 @entity95 : G1, untreated controls; G2, @entity114 - @entity801 ; G3, @entity3402 - @entity801 ; G4, @entity2892 ; G5, @entity2892 - @entity801 ; G6, @entity11248 ; G7, @entity11248 - @entity801 ; G8, @entity2176 and G9, @entity2176 - @entity801 . Response to therapy was evaluated by mortality curves, as negative blood cultures, concentration of @entity885 in aortic vegetations and rate of sterilization of vegetations. RESULTS: Vegetation weight was significantly lower in treated groups than in controls; lower weights were found in G5, 6, and 9. G9 sterilized 75% of the vegetations. @entity204 occurred in 25% of the control group and in 4.76% of G6 and 7. Blood cultures became negative most rapidly in G9. CONCLUSIONS: Combined treatment with @entity2176 - @entity801 may be highly efficacious in @entity1 with @entity884 caused by @entity114 -resistant @entity885 . Other combinations, such as @entity2892 - @entity801 and @entity11248 - @entity801 , may be also advantageous.
