Bone marrow histology and serum XXXX in @entity1582 --a new prognostic strategy.

@entity1 @entity417 @entity706 @entity5 @entity2262 @entity1582 @entity690
Bone marrow biopsies of 720 @entity1 with @entity1582 ( @entity1582 ) were investigated from 1968-1989. Histologic variables were correlated with clinical parameters and survivals to determine prognostic factors. In 207 of these @entity1 initial levels of serum @entity2262 (SB2M) were also measured for prognostic evaluation. Four @entity5 growth patterns were distinguished: interstitial (56%), interstitial/sheets (13%), nodular (15%) and packed marrow (16%) with median survivals of 46, 31, 22 and 16 months. When grouped according to the @entity5 cell mass in the biopsy, four histologic stages were recognized. Cellular characteristics were used to classify @entity1582 into 6 histologic types which were subsequently combined into 3 grades of @entity5 : low, intermediate and high, analogous to the @entity706 . With respect to @entity5 products, only SB2M proved to be a valuable prognostic indicator for staging and follow-up. Complications of @entity1582 such as @entity417 , azotaemia, @entity690 , hypercalcaemia and hypoalbuminaemia all predicted a poor prognosis, highly significant in the test statistics. We propose a new prognostic approach in @entity1582 , comprising 1) parameters defining the @entity5 itself, 2) the @entity5 products (SB2M) and 3) the @entity5 complications. This prognostic strategy combines information both on stage and @entity5 of @entity1582 and enables definition of smouldering and of aggressive variants of @entity1582 at an early stage.
