Breast-fed @entity1 achieve a higher rate of brain and whole body @entity7238 accumulation than formula-fed XXXX not consuming dietary @entity7238 .

@entity1 @entity7238 @entity844 @entity4601 @entity52126
@entity7238 ( @entity4601 ) has been increasingly recognized as an important @entity844 for neural and visual development during the first 6 mon of life. One important point of controversy that remains is the degree to which adequate levels of @entity4601 can be acquired from endogenous synthesis in @entity1 vs. what should be provided as dietary @entity4601 . We have approached this problem by a retrospective analysis of published body composition data to estimate the actual accumulation of @entity4601 in the @entity1 @entity1 brain, liver, adipose tissue, remaining lean tissue, and whole body. Estimating whether @entity1 can synthesize sufficient @entity4601 required comparison to and extrapolation from animal data. Over the first 6 mon of life, @entity4601 accumulates at about 10 mg/d in the whole body of breast-fed @entity1 , with 48% of that amount appearing in the brain. To achieve that rate of accumulation, breast-fed @entity1 need to consume a minimum of 20 mg @entity4601 /d. Virtually all breast milk provides a @entity4601 intake of at least 60 mg/d. Despite a store of about 1,050 mg of @entity4601 in body fat at term birth and an intake of about 390 mg/d @entity52126 (alpha-LnA), the brain of formula-fed @entity1 not consuming @entity4601 accumulates half the @entity4601 of the brain of breast-fed @entity1 while the rest of the body actually loses @entity4601 over the first 6 mon of life. No experimental data indicate that formula-fed @entity1 not consuming @entity4601 are able to convert the necessary 5.2% of alpha-LnA intake to @entity4601 to match the @entity4601 accumulation of breast-fed @entity1 . We conclude that dietary @entity4601 should likely be provided during at least the first 6 mon of life.
