The genetics of XXXX in allergic disease.

@entity402 @entity2939 @entity5750
PURPOSE OF REVIEW: The 'hygiene hypothesis' implies that infections in early childhood prevent the development of @entity402 . Atopy is caused by the interaction of the environment with genetic factors. Therefore, both contacts with microbial products such as endotoxin as well as @entity5750 , a gene involved in the immunological response to endotoxin, are discussed in this review. RECENT FINDINGS: @entity5750 is a multifunctional receptor for endotoxin and other bacterial wall components. Membrane-bound @entity5750 is expressed on monocytes and macrophages. It forms a complex with @entity2939 . Genetic studies have shown an association of variants in the @entity5750 gene with the prevention of (and severity of) @entity402 . However, phenotype definitions and the allele that showed association differed between studies. In addition, the presence of endotoxin in house dust appears to be inversely related to @entity402 in different studies. SUMMARY: It can be hypothesized that different levels of endotoxin exposure could interact with specific @entity5750 variants in the prevention of @entity402 . If confirmed in prospective cohort studies, this might represent an important gene by environmental interaction in the development of @entity402 . This could possibly open ways for the primary prevention of @entity402 .
