Genetic variation at the XXXX locus: evidence for association with long-term outcome after @entity385 .

@entity1 @entity64 @entity2252 @entity71776 @entity385
BACKGROUND AND PURPOSE: Rates and extent of recovery after @entity64 vary considerably between individuals and genetic factors are thought to contribute to post- @entity64 outcome. @entity2252 ( @entity2252 ) plays important roles in brain plasticity and repair and has been shown to be involved in @entity64 severity, recovery, and outcome in animal models. Few clinical studies on @entity2252 genotypes in relation to @entity385 have been performed. The aims of the present study are therefore to investigate whether genetic variation at the @entity2252 locus is associated with @entity64 , recovery and/or short-term and long-term functional outcome after @entity385 . METHODS: Four @entity2252 tagSNPs were analyzed in the Sahlgrenska Academy Study on @entity385 (SAHLSIS; 600 @entity1 and 600 controls, all aged 18-70 years). @entity64 severity was assessed using the NIH @entity64 Scale (NIHSS). @entity64 recovery was defined as the change in NIHSS over a 3-month period. Short- and long-term functional outcome post- @entity64 was assessed using the modified Rankin Scale at 3 months and at 2 and 7 years after @entity64 , respectively. RESULTS: No SNP was associated with @entity64 severity or recovery at 3 months and no SNP had an impact on short-term outcome. However, @entity71776 was independently associated with poor functional outcome 7-years after @entity64 (OR 0.66, 95% CI 0.46-0.92; P= 0.006). CONCLUSIONS: @entity2252 gene variants were not major contributors to @entity385 severity, recovery, or short-term functional outcome. However, this study suggests that variants in the @entity2252 gene may contribute to poor long-term functional outcome after @entity385 .
