XXXX of the sellar region--a review.

@entity6010 @entity1 @entity5 @entity1373 @entity2124 @entity977 @entity652 @entity528
@entity6010 are benign, @entity528 and are found for the most part in @entity1 and young adults. They are most often localized in either the spinal cord or the cerebral hemispheres. @entity6010 in the sellar region are extremely rare and only 43 such @entity5 (including 4 own cases) have ever been described in the literature. Although these @entity5 are genuine rarities without any epidemiological importance, they do provide some interesting information on tumorigenesis of @entity977 : 65% of the @entity6010 are associated with a @entity977 . 74% of @entity1 with these @entity5 suffered hormonal oversecretion of at least one of the pituitary hormones (mostly @entity2124 ). With only one exception, the hypothalamic releasing hormone corresponding to the hormonal oversecretion syndrome could be demonstrated in the @entity6010 immunohistochemically. Ultrastructural studies could demonstrate close cell to cell contacts between @entity652 and gangliocytome cells. All these data support the hypothesis that chronic overstimulation by hypothalamic releasing hormones play a role in the development of hormone secreting @entity977 . However, in contrast to sellar gangliocytemas, extrahypothalamic @entity5 secreting excessive hypothalamic hypophysiotropic hormones have never been associated with a @entity977 . They have only been associated with @entity1373 . Therefore, the hypothesis can be made that hypothalamic releasing hormones only promote but do not initiate tumorigenesis of @entity977 .
