How Does XXXX -DBS Affect Speech in @entity3520 ?

@entity1 @entity3520 @entity14243 @entity73 @entity7364 @entity8408 @entity3519 @entity4653
BACKGROUND: Globus pallidus internus deep brain stimulation ( @entity14243 -DBS) can be an effective treatment for @entity3520 . However, @entity8408 have previously been reported as a common possible side effect of the treatment. OBJECTIVES: To study possible deterioration of speech after @entity14243 -DBS and describe this in different dimensions. METHODS: Speech was systematically evaluated in 15 @entity1 with predominant torticollis and @entity14243 -DBS. Each @entity1 was tested twice within one day in two stimulation conditions: ON-DBS vs. OFF-DBS. Speech analyses comprised both function-oriented (perceptual scales, acoustic analyses) and communication-related measures (intelligibility, naturalness). A control sample of 15 healthy speakers underwent the same speech assessment. RESULTS: On the group level, @entity1 with @entity3519 showed mild but significant @entity73 scale, the intelligibility score, and the naturalness ratings in both stimulation conditions (Mann-Whitney, P  <  .05). No stimulation-induced deterioration was found. A slight increase in articulation rate was measured in the ON condition. On the single-case level, effects of @entity14243 -DBS on speech were heterogenous. In one @entity1 we observed a deterioration of speech ( @entity4653 ), in a second @entity1 with a history of childhood stuttering we found an aggravation of dysfluency. Impressive benefits could be documented in another @entity1 who also suffered from @entity7364 . CONCLUSIONS: The study provides evidence that @entity73 is not a necessary side-effect of @entity14243 -DBS in @entity3520 . Both, recurring of stuttering and a worsening of @entity4653 may be seen in individual @entity1 . The positive effects of @entity14243 -DBS on the symptoms of @entity7364 merits further research as DBS is not commonly applied in this population.
