Rapid assessment of cerebral autoregulation by near-infrared spectroscopy and a single dose of XXXX .

@entity1 @entity101 @entity3124 @entity3194 @entity2647
Rapid bedside determination of cerebral blood pressure autoregulation (AR) may improve clinical utility. We tested the hypothesis that cerebral Hb oxygenation (HbDiff) and cerebral Hb volume (HbTotal) measured by near-infrared spectroscopy (NIRS) would correlate with cerebral blood flow (CBF) after single dose @entity2647 (PE). @entity3124 @entity1 requiring artificial ventilation and arterial lines were eligible. During rapid blood pressure rise induced by i.v. PE bolus, /\HbDiff and /\HbTotal were calculated by subtracting values at baseline (normotension) from values at peak blood pressure elevation ( @entity101 ). With the aid of NIRS and bolus injection of @entity3194 , relative measures of CBF, called blood flow index (BFI), were determined during normotension and during @entity101 . BFI during @entity101 was expressed as percentage from BFI during normotension (BFI%). Autoregulation indices (ARIs) were calculated by dividing BFI%, /\HbDiff, and /\HbTotal by the concomitant change in blood pressure. In 24 @entity1 (11 newborns and 13 @entity1 ), significant correlations between BFI% and /\HbDiff (or /\HbTotal) were found. In addition, the associations between Hb-based ARI and BFI%-based ARI were significant with correlation coefficients of 0.73 (or 0.72). Rapid determination of dynamic AR with the aid of cerebral Hb signals and PE bolus seems to be reliable.
