Systematic review with meta-analysis: post-infectious XXXX after travellers' @entity294 .

@entity1 @entity5377 @entity8527 @entity294 @entity344 @entity1902 @entity1744
BACKGROUND: @entity344 is known as a risk factor for the development of the @entity1744 (post-infectious @entity1744 , @entity5377 ). The incidence of @entity5377 ranges between 3% and over 30% of @entity1 after @entity1902 . AIM: To perform a meta-analysis pools and report data concerning the relative risk (RR) of @entity5377 after @entity8527 . METHODS: Database search using Medline through PubMed, Scopus, EBM Reviews (Cochrane Database of Systematic Reviews) and PsycINFO was performed to identify relevant studies. Those that met the inclusion criteria were pooled. A random effects model (Mantel-Haenszel) was performed. RESULTS: Six eligible studies were found. In three of six studies, the authors reported a statistically significant association of @entity8527 and @entity5377 . The pooled RR was 3.35 (95% CI: 2.22-5.05) with a significant overall effect (P  <  0.00001). Overall @entity5377 incidence was 5.4% in @entity8527 subjects and 1.4% in healthy subjects. There was no significant heterogeneity within the pooled studies (I(2)   =  5%). Self-reported @entity8527 alone resulted in an over 1.5-fold RR for @entity5377 compared to laboratory-confirmed @entity8527 [RR 3.90 (95% CI: 2.35-6.49) vs. RR 2.42 (95% CI: 1.22-4.78)]. CONCLUSIONS: There is a strong association between travellers' @entity294 and post-infectious @entity1744 . Self-reports of exposure seem to result in a higher post-infectious @entity1744 occurrence than laboratory-confirmed cases of travellers' @entity294 , but further studies are needed to confirm this finding. Finally, potential influences of the selection of an appropriate study population on post-infectious @entity1744 epidemiology are discussed.
