Neurological and pathological improvements of @entity385 in XXXX with @entity902 nanoparticles.

@entity63 @entity19 @entity2500 @entity16 @entity26 @entity23410 @entity1235 @entity1188 @entity224 @entity902 @entity385
@entity385 is a major, urgent @entity16 in which reactive @entity26 species (ROS) are deeply involved in the detrimental effects. @entity902 nanoparticle (nPt) species are a novel and strong scavenger of such ROS, so we examined the clinical and neuroprotective effects of nPts in @entity19 @entity63 brain. @entity19 were subjected to transient @entity2500 (tMCAO) for 60 min. Upon reperfusion, nPt or vehicle was administered intravenously. At 48 hr after the tMCAO, motor function, @entity1188 volume, immunohistochemistry of neurovascular components (endothelial NAGO, tight junctional occludin, and basal laminal collagen IV), and zymography for @entity1235 activity were examined. @entity224 anion generation at 2 hr after tMCAO was determined with oxidized @entity23410 . Compared with vehicle, treatment with nPts significantly improved the motor function and greatly reduced the @entity1188 volume, especially in the cerebral cortex. Immunohistochemical analyses revealed that tMCAO resulted in a minimal decrease of NAGO and occludin but a great decrease of collagen IV and a remarkable increase of @entity1235 . Treatment with nPts greatly reduced this decrease of collagen IV and activation of @entity1235 and, with large reductions of @entity1235 activation on zymography and @entity224 production. The present study demonstrates that treatment with nPts ameliorates the neurological scores with a large reduction in @entity1188 size as well as the preservation of outer components of the neurovascular unit (collagen IV) and inactivation of @entity1235 . A strong reduction of @entity224 anion production by nPts could account for such remarkable neurobehavioral and neuroprotective effects on @entity385 .
