Immunologic studies in XXXX and control subjects.

@entity1 @entity2608 @entity161 @entity792
Heath and coworkers proposed that @entity161 may be an @entity792 in which antibodies are built up against specific substances in certain brain cells. Heath reports that @entity161 @entity1 exhibit abnormal brain waves in recordings from the caudate nucleus and septal area. These abnormal waves can also be recorded from similar sites in monkey brains after injections into the lateral ventricle cerebrospinal fluid of gamma-G-immunoglobulins (IgG) isolated from the blood of acutely ill @entity161 @entity1 . We prepared IgG fractions from control subjects and acutely ill @entity161 @entity1 and tested them in @entity2608 under double-blind conditions. Of 107 sera tested from 24 @entity161 @entity1 , 29 produced positive electroencephalographic recordings in the monkeys. From 30 control subjects we tested 80 samples and found 6 to be positive according to Heath's criteria. This amounts to more than 1 positive reaction for every 4 @entity161 @entity1 ' fractions tested and approximately 1 positive in 13 from control subjects' serum fractions. The difference between control and @entity1 groups is highly significant (p less than 0.001). Although our results confirm the experimental findings of the Heath group concerning abnormal EEG activity associated with an IgG fraction from @entity161 @entity1 , they differ from Heath's results for fractions from control @entity1 . We found positive effects from a small number of control fractions whereas Heath claims never to have observed positive biological activity in control fractions. The @entity792 has numerous drawbacks, the greatest of which is the inability to demonstrate the presence of circulating antibody in @entity161 @entity1 with the use of standard immunologic techniques.
