Angiotensin-(1-7) inhibits growth of @entity1 lung adenocarcinoma xenografts in @entity19 through a reduction in XXXX .

@entity1 @entity19 @entity5 @entity9859 @entity2 @entity2918 @entity1129 @entity916 @entity1996
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide of the @entity916 -angiotensin system with vasodilator and antiproliferative properties. Our previous studies showed that Ang-(1-7) reduced serum-stimulated growth of @entity1 @entity2 cells in vitro through activation of a unique @entity1129 ((1-7)) receptor. The current study investigates the effect of Ang-(1-7) on @entity2 growth in vivo, using a @entity1 @entity2 xenograft model. Athymic @entity19 with @entity5 resulting from injection of A549 @entity1 @entity2 cells were treated for 28 days with either i.v. saline or Ang-(1-7), delivered by implanted osmotic mini-pumps. Treatment with Ang-(1-7) reduced @entity5 volume by 30% compared with the size before treatment; in contrast, @entity5 size in the saline-treated animals increased 2.5-fold. These results correlate with a reduction in the proliferation marker Ki67 in the Ang-(1-7)-infused @entity5 when compared with the saline-infused @entity5 tissues. Treatment with Ang-(1-7) significantly reduced @entity1996 ( @entity1996 ) mRNA and protein in @entity5 of Ang-(1-7)-infused @entity19 when compared with @entity19 treated with saline as well as in the parent A549 @entity1 @entity2 cells in tissue culture. These results suggest that Ang-(1-7) may decrease @entity1996 activity and proinflammatory @entity2918 to inhibit @entity2 growth. In contrast, the heptapeptide had no effect on @entity9859 mRNA in xenograft @entity5 or A549 cells. Because Ang-(1-7), a peptide with antithrombotic properties, reduces growth through activation of a selective @entity1129 ((1-7)) receptor, our results suggest that the heptapeptide represents a novel treatment for @entity2 by reducing @entity1996 .
