Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative XXXX .

@entity1 @entity644 @entity8 @entity1009 @entity740 @entity1988 @entity454
BACKGROUND: Data on global (IV-G) and segmental (IV-S) diffuse proliferative @entity1988 (DPLN) in @entity1 are lacking. METHODS: To determine the clinicopathology and prognosis of DPLN subclasses IV-G and IV-S, we analyzed the clinical, laboratory, and demographic data of 56 @entity1 aged <18  years diagnosed with DPLN [36 (64.3  %) with IV-G; 20 (35.7  %) with IV-S] between 2004 and 2013. Clinical endpoints were: (1) complete remission (CR), (2) @entity740 [CKD; defined as estimated glomerular filtration rate (eGFR) of <60  mL/ @entity1009 .73  m(2) or @entity454 ( @entity454 )], and (3) death. RESULTS: @entity644 and the activity index were higher in @entity1 with IV-G (p   <   0.05). Global endocapillary proliferation and leukocyte exudation were predominant in IV-G @entity1 , whereas segmental endocapillary proliferation was predominant in @entity1 with IV-S (p   <   0.005). CR rates in IV-G and IV-S @entity1 were 50 and 60  %, respectively (p   =   0.47). Renal survival rates, defined as an eGFR of >= 60  mL/ @entity1009 .73  m(2), were 93, 78, and 64  % at 1, 5, and 10  years, respectively. @entity1 survival rates at 1, 5, and 10  years were 98, 96, and 91  %, respectively. @entity1 and renal survival rates were similar in both subclasses. CONCLUSIONS: Although @entity1 with IV-G and IV-S displayed some clinical and histopathological disparities, renal outcomes were similar. The majority of @entity1 with DPLN reached adulthood but accrued significant @entity8 . Treatment regimens which can slow the progression of CKD are needed.
