Impact of XXXX ( @entity9770 ) gene polymorphism on antiepileptic drug monotherapy in North Indian @entity302 population.

@entity1 @entity1501 @entity137 @entity9770 @entity9769 @entity1255 @entity1092 @entity2186 @entity2049 @entity302 @entity3174 @entity3562 @entity734
BACKGROUND AND OBJECTIVES: @entity734 ( @entity734 ) are known to interfere with @entity1255 metabolism. @entity3562 may be a risk factor associated in the long-term treatment with @entity734 . Both ge.netic and non-genetic factors are responsible for @entity3562 . @entity9769 @entity9770 polymorphism leads to the reduction in enzyme activity and subsequent elevation of plasma @entity1255 . This study aimed to investigate the role of @entity9769 @entity9770 polymorphism in @entity302 @entity1 receiving @entity734 as monotherapy ( @entity3174 , @entity2049 , and @entity1092 ) and showing @entity137 and non- @entity137 , and the impact of @entity734 on @entity3562 in North Indian population. DESIGN AND SETTINGS: Blood samples for this case-control study were collected from the outpatient depart.ment and wards of the Department of Neurosciences at the All India Institute of Medical Sciences, New Delhi, India, between July 2008 and May 2010. @entity1 AND METHODS: In this study, 200 @entity302 @entity1 and 100 normal controls were assessed for total @entity1255 (tHcy), @entity2186 , and @entity1501 levels using enhanced chemiluminescence enzyme immunoassay method (ImmuliteR, 1000 systems, DPC, United States); genotyping of @entity9769 @entity9770 was done using polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: The results showed a significant increase in tHcy levels in @entity302 @entity1 with @entity137 and non- @entity137 than in normal controls (P < .005). The allelic and genotypic distributions were found to be statistically significant in @entity137 and non- @entity137 groups (P < .05). CONCLUSION: The result confirmed that @entity3562 is common in adults receiving AED treatment for @entity302 with @entity137 and non- @entity137 groups. This increase in tHcy is mainly related to low @entity1501 and vita.min B12 levels, which are the main determinants for tHcy.
