Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in XXXX Spectrum Disorders: Influence of History of Language Delay.

@entity10791 @entity854 @entity72 @entity2438
UNASSIGNED: @entity72 ( @entity72 ) are a group of conditions that @entity854 in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the @entity2438 spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of @entity72 . In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in @entity72 individuals with and without a history of @entity10791 . We included 64 @entity72 adults of normal intelligence (37 without a history of @entity10791 and 27 with a history of @entity10791 ). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with @entity72 and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between @entity72 individuals with and without a history of @entity10791 in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that @entity72 subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. @entity2438 Res 2015, 8: 556-566.    2015 International Society for @entity2438 Research, Wiley Periodicals, Inc.
