Simultaneous comparison of relative damage to chromatic pathways in XXXX and @entity726 : correlation with clinical measures.

@entity1 @entity227 @entity1538 @entity101 @entity726 @entity2790 @entity7085
PURPOSE: To use a new methodological approach, based on luminance noise, to assess without bias the relative damage of blue-yellow and red-green pathways in @entity2790 and @entity726 and to correlate obtained measurements with clinical markers of disease progression. METHODS: A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: @entity1 with primary @entity1538 (n = 51 eyes), @entity1 with @entity2790 (n = 95 eyes), and control subjects (n = 46 eyes). Viewing conditions were such that the function of the macula was being tested, using a discrimination task under noisy conditions. Confusion vectors, and parameters obtained from discrimination @entity7085 were correlated with perimetric and clinical data taken from the same groups. RESULTS: The lengths of the major axis of chromatic discrimination @entity7085 and all confusion vectors were significantly different between the groups. These measures followed a significant gradient of worsening performance from the control to @entity101 and @entity726 groups, which was steeper for the tritan axis. There was a significant global positive correlation between test parameters and cup-to-disc ratio and a significant negative correlation with the perimetric mean deviation index. @entity7085 length in @entity1 with @entity2790 correlated significantly with the duration of their @entity101 state. CONCLUSIONS: This psychophysical test can detect @entity227 in a significant subset of @entity1 with long-term @entity101 with preserved visual fields. Macular function is damaged earlier than previously believed, in both the blue-yellow and red-green pathways.
