Hepatobiliary system in XXXX .

@entity1 @entity82 @entity390 @entity1087 @entity39 @entity879 @entity3458 @entity5990 @entity2679 @entity490 @entity382 @entity99 @entity221 @entity2877
This paper reviews the literature reports concerning @entity3458 . @entity3458 can cause progressive @entity99 with significant @entity82 , often @entity82 , and decreased liver function by adulthood. Asymptomatic @entity1 commonly have @entity382 and elevated liver enzyme levels. The presence of @entity3458 obscures features otherwise useful in differential diagnosis. Acute episodes of the disease selectively affect the liver in 10% of @entity1 , causing hepatic crisis with @entity490 , @entity390 , @entity221 , @entity1087 , and transaminase elevation. @entity99 is often clinically indistinguishable from hepatic crisis, but in @entity99 the @entity490 is usually less, the @entity1087 tends to be more severe, and the transaminase elevation more prolonged. The two can be distinguished by serology and liver biopsy. Furthermore, acute @entity2679 or @entity2877 may have clinical and laboratory features similar to sickle cell hepatic crisis or @entity99 . By adulthood, 50%-70% of sickle cell @entity1 have @entity5990 . Elective cholecystectomy is indicated for those who are symptomatic, but, because of operative mortality, there is disagreement concerning surgery for asymptomatic @entity1 . The literature contains nine well-documented cases of @entity879 related to @entity3458 . The mechanism is unclear; however, as the @entity39 is often not severe, a metabolic problem is suggested.
