Contact @entity56 response to @entity3304 ( XXXX ) in @entity35 : insight from sensitization phase.

@entity7940 @entity19 @entity12718 @entity568 @entity13358 @entity3304 @entity56 @entity35
@entity56 ( @entity56 ) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. Majority of @entity56 studies were conducted in @entity19 and there is paucity of data in other experimental animals. In the present study, characteristics of contact @entity56 reaction to @entity3304 ( @entity3304 ) were determined in Th1-prone Dark Agouti (DA) @entity35 by evaluating sensitization phase as a function of time-dependent changes in draining lymph nodes (DLN). Apart from basic indices of DLN activity (cellularity and proliferation), the production of cytokines relevant for @entity56 induction, @entity568 ( @entity568 ), interferon-y (IFN-y), @entity7940 ( @entity7940 ) and @entity12718 ( @entity12718 ) was analyzed. Anti-inflammatory cytokine @entity13358 ( @entity13358 ) production by DLN cells was determined as well. Highest production of @entity568 , IFN-y and @entity7940 in sensitized animals was observed at day 3 after @entity3304 application, with a decrease at day 5. Increased messages for IFN-y and @entity7940 were noted at this time point. In contrast to inflammatory cytokines, anti-inflammatory cytokine @entity12718 ( @entity12718 ) was undetectable during the entire sensitization phase. Differential pattern ( @entity568 and IFN-y) and level (IFN-y and @entity7940 ) of inflammatory cytokine production was noted in sensitized Th2-prone Albino Oxford (AO) @entity35 . Similarly to DA @entity35 , no changes in @entity12718 were noted in AO @entity35 -dependent differences in inflammatory cytokine production seem to be based on anti-inflammatory cytokine @entity13358 ( @entity13358 ). Production of IFN-y concomitantly with undetectable @entity12718 in both strains classify @entity35 @entity56 to @entity3304 as Th1/type 1 reaction. Detection of @entity7940 in sensitized DLN cells points to the involvement of T( @entity7940 ) cells in @entity35 contact @entity56 .
