What is required in terms of mass drug administration to interrupt the transmission of schistosome parasites in regions of XXXX ?

@entity1 @entity281 @entity2040
BACKGROUND: @entity2040 is endemic in 54 countries, but has one of the lowest coverages by mass drug administration of all helminth diseases. However, with increasing drug availability through donation, the World Health Organisation has set a goal of increasing coverage to 75  % of at-risk @entity1 in endemic countries and elimination in some regions. In this paper, we assess the impact on @entity2040 of the WHO goals in terms of control and elimination. METHODS: We use an age-structured deterministic model of schistosome transmission in a @entity1 community and the effect of mass drug administration. The model is fitted to baseline data from a longitudinal re-infection study in Kenya and validated against the subsequent re-infection data. We examine the impact on host worm burden of the current treatment trend, extrapolated to meet the WHO goals, and its sensitivity to uncertainty in important parameters. We assess the feasibility of achieving elimination. RESULTS: Model results show that the current treatment trend, extrapolated to the WHO goals, is able to greatly reduce host worm burdens. If coverage is continued at the same level beyond 2020, elimination is possible for low to moderate transmission settings, where transmission intensity is defined by the basic reproduction number, R0. Low levels of adult coverage have a significant impact on worm burden  in all settings. Model validation against the re-infection survey demonstrates that the age-structured model is able to match post-treatment data well in terms of egg output, but that some details of re-infection among school @entity1 and young adults are not currently well represented. CONCLUSIONS: Our work suggests that the current WHO treatment goals should be successful in bringing about a major @entity281 in treated communities. If continued  over a 15 year period, they are likely to result in elimination, at least in areas with lower transmission.
