@entity6654 : cell type, growth factor expression, and XXXX angiographic and retinal photographic correlations.

@entity2283 @entity3145 @entity7 @entity538 @entity6654 @entity2277 @entity941 @entity6474
BACKGROUND: We studied the cellular constituents and the expression of @entity7 ( @entity7 ) and transforming growth factor-beta ( @entity6474 ) in @entity6654 (ERMs), attempting to correlate the presence of these growth factors with @entity941 leakage during angiography and with the amount of @entity3145 . METHODS: Idiopathic ERMs were excised at vitrectomy in 41 consecutive cases and stained for @entity538 ( @entity538 ), @entity2277 , cytokeratin, @entity2283 and actin. A subset of 13 cases for which @entity941 angiograms and colour retinal photographs were available was further studied for the presence of @entity7 and @entity6474 in the ERMs, @entity941 leakage and amount of @entity3145 . RESULTS: Of the 41 ERMs, 31 (76%) were found to be fibroglial by light microscopy; 40 (98%) stained for @entity538 , 39 (95%) for @entity2277 , 10 (24%) for cytokeratin, 3 (7%) for @entity2283 and 11 (27%) for actin. Of the 13 ERMs in the subset, staining was positive for @entity7 in 11 (85%) and for @entity6474 in 11 (85%). There was no statistically significant relationship between the presence of @entity7 and leakage (p = 0.68) or between the presence of @entity6474 and scar size (p = 0.90). When both @entity7 and @entity6474 were present, there was likely to be leakage or a large scar, or both, which suggested that an interaction exists between the two growth factors (p = 0.057). When leakage occurred, large scars were 2.5 times less likely to be present; when no leakage occurred, large scars were 2.5 times more likely to be present (odds ratio 0.4; Yules association coefficient -0.43). INTERPRETATION: The cells constituting idiopathic ERMs were primarily fibroglial with minimal staining evidence for the presence of contractile proteins in their cytoplasm. @entity7 and @entity6474 were present in 85% of specimens. Although there was no direct correlation between the presence of these growth factors and either @entity941 leakage or the abundance of scar tissue respectively, there was some evidence for the interaction of these growth factors in producing either leakage or abundance of scar tissue.
