Effects of thrombolytic therapy on evolution of left ventricular function in XXXX .

@entity1 @entity1188 @entity432 @entity583 @entity850
Use of thrombolytic therapy in the early hours of @entity583 ( @entity583 ) has gained widespread acceptance. One potential benefit of early reperfusion could be improved left ventricular (LV) function. Experimental animal studies have demonstrated that duration of coronary occlusion determines ultimate @entity1188 size and have also raised the issue of reperfusion injury. The evolution of LV function after @entity583 in @entity1 where there is no attempt at early reperfusion is discussed. Studies of LV function following thrombolytic therapy in @entity1 have illustrated the following points. Time to successful reperfusion appears to be a critical determinant for potential for LV functional recovery. If reperfusion is achieved within 2.5 hours after onset of symptoms, consistent recovery of function within the @entity1188 zone appears to be possible. With reperfusion from 2.5 to six hours after onset of symptoms, there is no predictable, substantial improvement in either global or regional LV function. Within the framework of this general conclusion, there are three potential exceptions: Successful reperfusion up to six hours after onset of symptoms may prevent @entity1188 expansion. @entity1 with subtotal occlusion of the @entity1188 vessel prior to therapy in this time period may have more potential for recovery of LV function than those with @entity432 . A tight residual @entity850 following thrombolytic therapy may mask potential for functional recovery in the @entity1188 zone. Earlier diagnosis and treatment of @entity583 is one obvious solution for the overall lack of beneficial results on evolution of LV function seen in most studies to date.(ABSTRACT TRUNCATED AT 250 WORDS)
