The impaired synthesis of insulin and its inability to inhibit XXXX in cerebrovascular accident.

@entity64 @entity6 @entity1423 @entity19 @entity117 @entity21652 @entity1723 @entity842 @entity715 @entity413 @entity385
UNASSIGNED: Both @entity385 ( @entity385 ) and @entity64 ( @entity64 ) are reported to occur due to @entity715 on the arteries of the brain. As @entity6 is a risk factor for @entity64 and insulin is reported to prevent @entity715 , the role of insulin in @entity385 and @entity64 was investigated. Forty eight @entity64 victims ( @entity385  =  22, @entity64  =  26) and equal number of aged and sex matched normal volunteers participated in the study. @entity842 was determined by methemoglobin method. Insulin and Dermcidin isoform-2 (DCN2) level was determined by ELISA by using insulin and dermcidin antibody. Insulin binding to the platelet membrane was analyzed by scat chard plot. Treatment of normal platelet rich plasma (10(8)platelets/ml) with 15 Units insulin/ml produced 1.41  nmol NO. The @entity21652 from the @entity385 and @entity64 victims produced 0.38  nmol NO and 0.08  nmol NO respectively. Pretreatment of @entity21652 from @entity385 or @entity64 subjects with 15   M @entity117 followed by 15 Units of insulin/ml resensitized the platelets to the inhibitory effect of insulin. @entity19 hepatocytes treated with 0.14   M DCN2 abolished the @entity413 induced insulin synthesis by NO that can be reversed by using 15   M @entity117 . It can be concluded that presence of DCN2 in @entity64 causes a condition similar to @entity1723 and nullified the effect of insulin in the inhibition of @entity1423 in both @entity385 and @entity64 . The effect was reversed by 15   M @entity117 .
