Characteristics associated with early and late XXXX @entity3 .

@entity1 @entity5 @entity1489 @entity1066 @entity3 @entity320
BACKGROUND: Differences in risk factors for @entity3 at different time intervals after treatment have been described in several @entity5 ; however, to the authors' knowledge, no extensive study examining this issue in @entity320 has been conducted to date. METHODS: The authors performed a nested case-control study of @entity1 with @entity320 who presented with only local disease. @entity1 in the case group included 549 @entity1 who developed @entity3 > or =6 months after surgery. Of these, 320 @entity1 developed @entity3 within 3 years after undergoing definitive surgery (early @entity3 [EM]), and 70 @entity1 developed @entity3 > or =8 years after undergoing definitive surgery (late @entity3 [LM]). For each case, a control @entity1 was chosen who had @entity320 but who did not develop @entity3 in the same interval. Univariate and conditional multivariate logistic regression were used in the analysis of 34 clinical and @entity5 characteristics. RESULTS: Multivariate analysis confirmed previously established risk factors for @entity3 , such as increasing @entity5 thickness. In addition, the authors discovered that a personal history of @entity1489 (P = .006) and a history of @entity5 (P = .020) also were associated with @entity3 . In comparing the 320 EM @entity1 with the 70 LM @entity1 , EM @entity1 were more likely to have thicker lesions (P < .001), @entity1066 (P = .016), and a history of @entity1489 (P = .024). CONCLUSIONS: In this study, 2 potentially novel risk factors for @entity320 @entity3 were identified, and different profiles of risk factors were constructed for EM versus LM. These differences may be important in future risk identification and stratification for clinical trials and for the management and treatment of @entity1 with @entity320 .
