XXXX depletion and residues in eggs after oral administration to laying hens.

@entity3403 @entity1626 @entity18687 @entity11439 @entity10003
UNASSIGNED: The depletion of @entity3403 (DC) residues in eggs was determined after oral drug administration by drinking water to laying hens. The antibiotic was supplied to birds for 5 consecutive days and the eggs were collected during medication and 18  days after withdrawal. DC residues were determined by LC-MS/MS. DC was isolated from eggs with a solution of 0.02  M of @entity11439 ( @entity10003 ), 0.1  M @entity18687 and @entity1626 . The limit of detection (LOD) and limit of quantification (LOQ) of the method were 2 and 5    g  kg(-1), respectively. Analyses were performed on whole egg, egg white and yolk separately. DC was detectable 24  h after the beginning of administration. The concentration of antibiotic increased daily, resulting in the highest DC concentration in whole eggs at the first day of the withdrawal period. Thirteen days after withdrawal, the content of DC in whole eggs was below the LOQ of the method. However, some differences were found in the depletion curve of DC between egg white and yolk. Residues of DC in egg white were much higher during treatment and 1 day after withdrawal, but later the concentration in egg white decreased fairly rapidly and a higher DC content in egg yolk was observed. The depletion period was shorter for egg white than for yolk, and DC was detected in the egg white until 12  days after withdrawal and 2  days more in egg yolk than in white. DC reached a peak faster in egg white, but the residues were detectable for longer period in the yolk.
