Effect of acute cigarette smoking, alone or with XXXX , on gastric barrier function in healthy volunteers.

@entity1 @entity167 @entity16 @entity969 @entity356
BACKGROUND: Smoking is a risk factor for gastroduodenal ulcer and @entity356 . However, the pathophysiological mechanisms induced by acute cigarette smoking in the @entity1 gastric mucosa are poorly understood. AIM: To evaluate the effect of acute cigarette smoking, alone or with @entity167 , on the gastric permeability to @entity969 , a specific marker of @entity16 in the stomach. SUBJECTS AND METHODS: Twenty healthy volunteers (8 smokers/12 non-smokers) were studied. Each fasted subject ingested 500 ml of a 20% @entity969 solution and the amount of @entity969 excreted in a 5-hour urine collection was measured by gas chromatography Four @entity969 permeability tests were carried out: 1. basal, 2. while smoking 5 cigarettes, 3. after drinking 50 ml of a 40 degrees alcoholic beverage, 4. a combination of 2+3. RESULTS: @entity969 excretion increased after @entity167 ingestion (40.5 +/- 6.0 mg vs 143.1 +/- 28.9 mg, p = 0.002), but was not modified by acute cigarette smoking (34.4 +/- 5.9 mg). When @entity167 and cigarettes were simultaneously consumed, the increase in @entity167 -induced @entity969 excretion was significantly reduced (73.1 +/- 16.6 mg, p = 0.03). Basal @entity969 excretion was similar in smokers and non-smokers. However, in acute cigarette smoking, a decrease in @entity969 excretion was observed in smokers (p = 0.02) but not in non-smokers. CONCLUSIONS: These results indicate that acute cigarette smoking may tighten the gastric mucosa in habitual smokers and this is associated with a smaller increase of gastric permeability induced by @entity167 .
