Antinociceptive effect of XXXX in adjuvant arthritic @entity35 .

@entity308 @entity33885 @entity35 @entity4411 @entity37655
The antinociceptive effect of @entity33885 (CPC) and @entity37655 were examined in adjuvant arthritic @entity35 . In the behavioral study, @entity4411 (100-400 mg/kg, p.o.) but not @entity37655 (100-400 mg/kg, p.o.) had a dose-dependent antinociceptive effect, determined using the flexion test. In the electrophysiological study, CPC (25-50 mg/kg, i.v.) but not @entity37655 (50 mg/kg, i.v.) @entity308 the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB), while the evoked responses of non-nociceptive neurons were not @entity308 by either CPC (50 mg/kg, i.v.) or @entity37655 (50 mg/kg, i.v.). The spontaneous firings of the VB nociceptive neurons were @entity308 by both CPC (50 mg/kg, i.v.) and @entity37655 (50 mg/kg, i.v.). However, @entity37655 (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also @entity308 the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic @entity35 . These results indicate that CPC but not @entity37655 , has an antinociceptive action in adjuvant arthritic @entity35 .
