Arterial dysfunction in XXXX : results of arterial reactivity and pulse wave propagation tests.

@entity1 @entity296 @entity101 @entity6 @entity66 @entity1242 @entity1112 @entity409 @entity731 @entity122
OBJECTIVE: To assess arterial distensibility using pulse wave velocity ( @entity122 ) measurements and its relation with endothelium dependent vasodilatation (EDV) in @entity1 with cardiological @entity1112 . METHODS: The study group consisted of 92 @entity1 : 52 with @entity1112 (34 @entity1 , 18 @entity1 , mean (SD) age 45 (3) years) and 40 healthy volunteer controls (27 @entity1 , 13 @entity1 , mean (SD) age 41 (2) years) without risk factors of @entity731 and with negative ECG exercise test and normal proximal coronaries on transoesophageal echocardiography. @entity1 with @entity101 , @entity6 , @entity66 , or @entity296 were excluded. @entity122 measured by a Complior Colson device was calculated for each @entity1 . EDV was assessed from two dimensional Doppler measurement using an Acuson Sequoia with 8 MHz linear transducer at rest, during postischaemic reactive hyperaemia, and after an oral dose of 400 micro g of @entity1242 . RESULTS: @entity122 was significantly higher in @entity1 with @entity1112 than in healthy subjects (9.3 (0.7) m/s v 8.2 (0.9) m/s, respectively, p < 0.001). Baseline brachial artery diameter was similar in the @entity1112 and control groups (4.0 (0.6) mm v 4.08 (0.64) mm, NS). EDV was impaired in @entity1 with @entity1112 compared with controls (6.6 (3.0)% v 11.1 (3.9)%, p < 0.001). Endothelium independent vasodilatation was similar in both groups. In @entity1 with @entity1112 there was a positive correlation between @entity122 and the degree of EDV (r = 0.864, p < 0.001). The cut off value for @entity122 was 8.5 m/s, with a sensitivity of 62% and a specificity of 91%. CONCLUSIONS: EDV but not @entity1242 induced vasodilatation is decreased in @entity1 with @entity1112 . There is a strong correlation between @entity122 and the degree of @entity409 of peripheral arteries in @entity1 with @entity1112 . @entity122 assessment may be useful to identify abnormal vascular physiology in these @entity1 .
