Cytopathological Analysis of Cyst Fluid Enhances Diagnostic Accuracy of XXXX .

@entity1 @entity788 @entity660 @entity189 @entity787 @entity45 @entity22097 @entity1141
UNASSIGNED: Widespread use of cross-sectional imaging and increasing age of the general population has increased the number of detected @entity660 . However, several pathological entities with a variety in malignant potential have to be discriminated to allow clinical decision making. Discrimination between mucinous @entity788 ( @entity788 ) and nonmucinous @entity660 is the primary step in the clinical work-up, as malignant transformation is mostly associated with mucinous PCN. We performed a retrospective analysis of all resected PCN in our tertiary center from 2000 to 2014, to evaluate preoperative diagnostic performance and the results of implementation of the consensus guidelines over time. This was followed by a prospective cohort study of @entity1 with an undefined @entity45 , where the added value of cytopathological mucin evaluation to @entity787 ( @entity787 ) in cyst fluid for the discrimination of mucinous PCN and nonmucinous cysts was investigated. Retrospective analysis showed 115 @entity1 operated for a PCN, with a correct preoperative classification in 96.2% of the @entity1 . High-grade @entity1141 or @entity189 was observed in only 32.3% of mucinous PCN. In our prospective cohort (n=71), 57.7% of @entity1 were classified as having a mucinous PCN. @entity787 >= 192ng/mL had an accuracy of 63.4%, and cytopathological mucin evaluation an accuracy of 73.0%. Combining these 2 tests further improved diagnostic accuracy of a mucinous @entity22097 to 76.8%. @entity787 level and mucin evaluation were not predictive of the degree of @entity1141 . These findings show that adding cytopathology to cyst fluid biochemistry improves discrimination between mucinous PCN and nonmucinous cysts.
