Dermal @entity3468 of the nasal philtrum in a Giant Schnauzer and three Saint Bernard XXXX .

@entity32 @entity34356 @entity548 @entity28284 @entity235 @entity1066 @entity3468 @entity4571 @entity158 @entity803 @entity1909
@entity3468 of the nasal philtrum is described in four @entity235 . Two of the Saint Bernards were related. The lesions were solitary, well-circumscribed, linear @entity1066 that were neither pruritic nor @entity158 . The age of the @entity235 at the time the owners first noticed the lesion ranged from 3 to 6 years. The @entity1066 had been present for 0.5-5 years before diagnosis was pursued. Three of the @entity235 experienced repeated, mild episodes of @entity548 from the @entity1066 . Two @entity235 also experienced a severe episode of @entity548 that required surgical intervention. Histopathological findings included a V-shaped @entity1066 , @entity32 subjacent to the @entity1066 and @entity1909 bordering the @entity1066 . The most remarkable pathological findings were present in the deep dermal arteries and arterioles subjacent to the @entity1066 . The changes were characterized by subendothelial spindle cell proliferation with marked extracellular matrix deposition that stained blue with Alcian Blue ( @entity34356 ) and Masson's trichrome (collagen) and resulted in intimal thickening, and stenosis of dermal arteries and arterioles. Immunohistochemical studies suggested that the proliferating spindle cells were of either myofibroblast or smooth muscle origin (actin and @entity28284 positive). Anti-inflammatory therapy (glucocorticoids; @entity803 and @entity4571 ; fish oil) may be beneficial for long-term control of this condition, however, long-term maintenance treatment appears to be necessary.
