Complications after radiotherapy and radical hysterectomy in XXXX .

@entity1 @entity172 @entity5 @entity4269 @entity344 @entity293
OBJECTIVE: To evaluate the overall complications, major as well as minor, in @entity1 treated for @entity5 as related to treatment parameters. METHODS: In this retrospective study, 167 consecutive @entity1 with @entity5 treated with preoperative radiotherapy and radical hysterectomy were investigated. Clinical data were collected from the medical files. RESULTS: Transient or permanent complications appeared in up to half of all @entity1 . Seven percent exhibited intraoperative complications and 35% suffered from early postoperative urinary tract problems; most frequently @entity293 . After one year, the urinary tract complications dominated; voidance difficulties and incontinence being most common. @entity344 occurred in 15% of @entity1 . @entity4269 appeared during the first year in 21% of the @entity1 but several of the mild or moderate cases improved after the first year. The relative risk of @entity4269 was increased with shorter duration of surgery, extensive preoperative irradiation to the bladder and after external postoperative irradiation. Some form of late sequelae remained in every fifth @entity1 , and every fourth @entity1 , aged 24-44 years, periodically suffered from vasomotor symptoms despite @entity172 replacement therapy. CONCLUSION: The complications after radiotherapy and radical hysterectomy in @entity5 suggest that attempts should be made to evaluate effective treatments designed to minimize risk to the @entity1 .
