Morphometric analysis of @entity1204 : 1. Does @entity1821 accompany deep invasion by XXXX ?

@entity1204 @entity1 @entity5 @entity6684 @entity189 @entity3 @entity1821
Important prognostic factors for @entity1204 include histologic differentiation, depth of @entity3 , and clinical stage. Deep myometrial penetration is more commonly observed with poorly differentiated @entity189 , but it is unknown if these @entity5 are poorly differentiated de novo, or if selection toward more aggressive, less differentiated cells occurs during invasion. To study this question, we performed a morphometric analysis to quantitate the amount of glandular differentiation in superficial portions of 22 @entity1204 for comparison with deep portions of the same @entity5 . Point counting of randomly selected fields was performed on histologic sections of hysterectomy specimens of 22 @entity1 with stage I @entity1204 . The components enumerated were @entity5 cells participating in gland formation ( @entity6684 ), non-gland-forming @entity5 cells (UI), @entity5 gland lumens (LUM), inflammatory cells (IC), and stroma (endometrium or myometrium) (ST). Slides of @entity5 were divided into superficial, middle, and deep thirds. No statistically significant differences were seen between superficial and deep thirds (UI: 45% vs. 43%; @entity6684 : 33% vs. 32%; LUM: 22% vs. 24%; IC: 3% vs. 3% of points counted, p greater than .1, paired t-test). The density of @entity5 cells relative to stroma was greater in the superficial region (55% vs. 41%, p less than .001, paired t-test). Additionally, field-to-field heterogeneity was examined by four methods. No relationship between increased heterogeneity and poor prognosis was identified. These findings do not support the concept that invasion by @entity1204 is accompanied by @entity1821 .
