Central Corneal Thickness Correlates With @entity26 Levels in the XXXX Anterior Chamber Angle.

@entity1 @entity2840 @entity267 @entity231 @entity26 @entity726 @entity4095
PURPOSE: To measure @entity26 ( @entity4095 ) in eyes of @entity1 undergoing intraocular surgery and identify correlations with @entity2840 ( @entity2840 ). DESIGN: Prospective, cross-sectional study. METHODS: setting: Institutional. @entity1 population: 124 @entity1 undergoing @entity231 and/or @entity726 surgery. observation procedure: Prior to surgery, an @entity26 sensor was introduced into the anterior chamber (AC) via peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned for 3 measurements in all @entity1 : (1) near central corneal endothelium; (2) in mid-AC; and (3) in AC angle. In @entity1 undergoing @entity231 extraction, additional measurements were taken (4) at the anterior lens surface and (5) in the posterior chamber. main outcome measures: @entity4095 measurements at 5 locations within the eye were compared to @entity2840 measurements by multivariate regression analyses. RESULTS: There was a statistically significant inverse correlation between @entity2840 and @entity4095 in the anterior chamber angle (P  = .048). @entity4095 was not significantly related to @entity2840 at any other location, including beneath the central @entity267 . Regression analysis relating @entity2840 to age, race, and @entity26 levels in all 5 locations in the anterior segment revealed an association of a thinner @entity267 with increasing age (P  = .007). CONCLUSIONS: Physiologic correlations with @entity2840 may provide clues to understanding why a thinner @entity267 increases the risk of open @entity726 . Associations between @entity726 risk, @entity2840 , and @entity4095 in the AC angle suggest that exposure of the outflow system to increased @entity26 or @entity26 metabolites may increase oxidative damage to the trabecular meshwork cells, resulting in elevation of intraocular pressure.
