Cardiac baroreceptor sensitivity predicts long-term outcome after acute XXXX .

@entity1 @entity64 @entity4375 @entity299 @entity943 @entity385
BACKGROUND AND PURPOSE: The baroreceptor reflex arc is important in the short-term regulation of the cardiovascular system, and small studies have reported @entity299 ( @entity4375 ) after @entity64 . However, the prognostic significance of impaired @entity4375 is uncertain. METHODS: One hundred twenty-four @entity1 underwent simultaneous ECG and noninvasive beat-to-beat blood pressure (BP) monitoring within 72 hours of neuroradiologically confirmed acute @entity385 . Cardiac @entity4375 was assessed from the combined alpha-index by means of power spectral analysis techniques. Baseline data for @entity64 @entity1 were compared with those of a control group matched for age, sex, and casual BP. @entity1 were followed up for a median of 1508 days (range, 9 to 2656 days), and outcome was compared between @entity1 with and without impaired @entity4375 . RESULTS: Median @entity4375 values were significantly lower in @entity64 @entity1 than in controls (5 [interquartile range, 3.5 to 7.4] versus 6.2 [interquartile range, 4.5 to 8.3] ms/mm Hg; P=0.04). Sixty-one (33 male) @entity1 (mean age, 70.2 [SD 10.5] years) had impaired @entity4375 (< or =5.0 ms/mm Hg) compared with 63 (35 male) @entity1 (mean age, 70.6 [SD 11.7] years) without impaired @entity4375 (>5.0 ms/mm Hg). @entity64 @entity1 with impaired @entity4375 values had a significantly poorer prognosis (28% versus 8% mortality rate during the follow-up period) although there were no differences in age, @entity64 severity, @entity64 type, or casual or 24-hour BP parameters between the 2 groups. CONCLUSIONS: Impaired cardiac @entity4375 is associated with increased long-term mortality after acute @entity385 , irrespective of age, sex, @entity64 type, and BP. This may reflect @entity943 , but the mechanisms underlying this association are unknown, although therapies that improve cardiac @entity4375 after @entity64 warrant further investigation.
