XXXX influences the risk of @entity726 by @entity2790 .

@entity725 @entity30626 @entity3547 @entity30716 @entity726 @entity5689 @entity48101 @entity43941 @entity2790 @entity21123 @entity29714 @entity50070 @entity71491 @entity61258
UNASSIGNED: @entity725 ( @entity725 ) is a blinding disease. Two important risk factors for this disease are a positive family history and @entity2790 (IOP), which is also highly heritable. Genes found to date associated with IOP and @entity725 are @entity21123 , @entity5689 / @entity30716 , @entity50070 and @entity43941 . However, these genes explain only a small part of the heritability of IOP and @entity725 . We performed a genome-wide association study of IOP in the population-based Rotterdam Study I and Rotterdam Study II using single nucleotide polymorphisms (SNPs) imputed to 1000 Genomes. In this discovery cohort (n = 8105), we identified a new locus associated with IOP. The most significantly associated SNP was @entity71491 (b = 0.44, P-value = 1.87 * 10(-8), minor allele frequency = 0.12), within the gene @entity61258 . Independent replication in five population-based studies (n = 7471) resulted in an effect size in the same direction that was significantly associated (b = 0.16, P-value = 0.04). The SNP was also significantly associated with @entity725 in two independent case-control studies [n = 1225 cases and n = 4117 controls; odds ratio (OR) = 1.53, P-value = 1.99 * 10(-8)], especially with high-tension @entity726 (OR = 1.66, P-value = 2.81 * 10(-9); for normal-tension @entity726 OR = 1.29, P-value = 4.23 * 10(-2)). @entity61258 plays an important role in the @entity3547 / @entity3547 kinase pathway, which has been implicated in IOP regulation. Furthermore, it binds to @entity21123 and links the @entity21123 , @entity5689 / @entity30716 and @entity50070 pathway to Mendelian @entity725 genes ( @entity29714 , @entity30626 , @entity48101 ). In conclusion, this study identified a novel association between IOP and @entity61258 .
