Visceral XXXX and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy @entity1 .

@entity1 @entity28 @entity4293 @entity146 @entity1674 @entity442 @entity1144 @entity1254
BACKGROUND: Prostate disease incidence is expected to rise among developing nations secondary to increased prevalence of @entity28 and the elderly. Although many case-control studies have associated @entity28 to prostate cancer @entity146 , few have correlated markers of prostate pathology to biomarkers of @entity1144 and insulin resistance, using an apparently healthy cohort. This study aims to fill this gap. MATERIALS AND METHODS: The 219 consenting adult Arab @entity1 , aged 30-70 years, were included in this cross-sectional study. Demographics were noted and anthropometrics measured. Fasting blood samples were extracted, and glycaemic and lipid profile were determined using routine laboratory methods. Serum adipocytokines and inflammatory markers were measured using multiplex assays. Total prostate-specific antigen (tPSA), free PSA (fPSA), parathyroid-related protein ( @entity4293 ) and endoglin were measured using enzyme-linked immunosorbent assays. RESULTS: Serum @entity1674 and waist-hip ratio (WHR) were significantly and positively associated with circulating (tPSA) levels in all subjects (P < 0  01). Systolic blood pressure (SBP), @entity1254 , active plasminogen activator inhibitor-1 ( @entity442 ( @entity442 ) had significant inverse associations to tPSA. Stepwise linear regression revealed that @entity1254 , @entity442 , WHR and @entity4293 explained 30% of variance in tPSA levels (P < 0  0001), while SBP, resistin and BMI explained 18  7% of variance in endoglin (P = 0  001). CONCLUSIONS: The associations of @entity1254 and WHR strengthen the link between insulin resistance and visceral adiposity to prostate volume markers among apparently healthy Arab @entity1 . Follow-up studies are needed to extend these preliminary findings so that early interventions can be provided to those at increased risk.
