XXXX intestinal epithelial cells express functional cytokine receptors sharing the common @entity16409 chain of the interleukin 2 receptor.

@entity1 @entity3647 @entity9597 @entity26159 @entity4666 @entity6977 @entity6978 @entity16409 @entity2902 @entity1199 @entity3646 @entity669
Interleukin (IL) 2 signaling requires the dimerization of the @entity3647 ( @entity3647 ) and common gamma ( @entity16409 ) chains. The gamma is also a component of the receptors for @entity3646 , @entity6977 , and @entity4666 . To assess the extent and role of the receptor signal transducing system utilizing the @entity16409 chain on @entity1 intestinal epithelial cells, the expression of @entity16409 , @entity3647 , and receptor chains specific for @entity3646 , @entity6977 , and @entity4666 was assessed by reverse transcription-coupled PCR on @entity1 intestinal epithelial cell lines and on isolated primary @entity1 intestinal epithelial cells. Caco-2, HT-29, and T-84 cells were found to express transcripts for the @entity16409 and @entity9597 chains constitutively. @entity3647 chain expression was demonstrated in Caco-2 and HT-29 but not in T-84 cells. None of the cell lines expressed mRNA for the @entity2902 chain. After stimulation with epidermal growth factor for 24 h Caco-2, HT-29, and T-84 cells expressed transcripts for @entity6978 . In addition, Caco-2 and HT-29 cells expressed mRNA for the @entity26159 . Receptors for @entity1199 , @entity3646 , @entity6977 , and @entity4666 on intestinal epithelial cells lines appeared to be functional; stimulation with these cytokines caused rapid @entity669 phosphorylation of proteins. The relevance of the observations in intestinal epithelial cell lines for intestinal epithelial function in vivo was supported by the demonstration of transcripts for @entity16409 , @entity3647 , @entity9597 , @entity6978 , and @entity26159 in primary @entity1 intestinal epithelial cells.
