Relationship between XXXX , @entity2538 gene polymorphisms and Peak Bone Mineral Density in College Students in China.

@entity2538 @entity4613 @entity66813 @entity79 @entity72068 @entity460 @entity72069 @entity560
BACKGROUND: @entity79 ( @entity79 ) is influenced by both genetic and environmental factors, genes explains most of variation. As the novel candidate genes @entity72068 and @entity2538 may have been associated with spinal @entity79 in adult. This study was to investigate the relationship among these two genes^ @entity79 and the life style factors in young female. METHODS: The @entity72069 single nucleotide polymorphism (SNP) of the @entity72068 gene and the @entity66813 SNP of the @entity2538 gene were genotyped using SNaPshot   in 359 students from Xinjiang. The prospective study included 203 Han and 156 Uyghur subjects. @entity79 was measured using quantitative computed tomography (QCT). @entity460 , @entity4613 and alkaline phosphatase were measured by ELISA method. Physical activity, dietary @entity460 and life styles were assessed by questionnaire. RESULTS: Both SNPs showed differences in genotype and allele frequencies (P < 0.05) between the Han and Uyghur subjects. Total @entity460 intake, energy intake, tea and milk intake were also significantly different between two groups (P < 0.05). Multiple regression analysis showed an association between @entity79 and @entity560 intake (P = 0.000), milk (P = 0.000), exercise (P = 0.029), @entity72069 (P = 0.028), energy intake (P = 0.043). CONCLUSION: This study demonstrated the polymorphisms of the @entity72069 and @entity66813 are associated with @entity79 both in Han and Uyghur subjects. @entity79 , in Xinjiang, appears to be associated with several known factors that are well described in the literature. While the genotypes of @entity72069 and @entity66813 do not appear have a strong effect on the @entity79 .
