@entity209 and risk of incident @entity6 : findings from the European Prospective Investigation into XXXX and Nutrition-Potsdam Study.

@entity1 @entity6 @entity5 @entity1144 @entity854 @entity209 @entity4854 @entity165
BACKGROUND: Several aspects concerning the relationship between the @entity209 and incident @entity6 are incompletely understood including the magnitude of the risk estimate, potential gender differences in the associations between the @entity209 and incident @entity6 , the associations between the components of the @entity209 and incident @entity6 , and whether the @entity209 provides additional prediction beyond its components. To shed light on these issues, we examined the prospective association between the @entity209 defined by the National @entity165 Education Program (NCEP) and International @entity6 Federation (IDF) and @entity6 . METHODS: We used data for 2796 @entity1 and @entity1 aged 35-65 years from the European Prospective Investigation into @entity5 and Nutrition-Potsdam Study followed for an average of 6.9 years. This analysis employed a case-cohort design that included 697 @entity1 who developed @entity6 and 2099 @entity1 who did not. Incident @entity6 was identified on the basis of self-reports and verified by contacting the @entity1 's attending physician. RESULTS: The adjusted hazard ratio for the NCEP definition was 4.62 (95% confidence interval [CI]: 3.90-5.48) and that for the IDF definition was 4.59 (95% CI: 3.84-5.50). The adjusted hazard ratios for the NCEP but not IDF definition were higher for @entity1 than @entity1 . When @entity1 who had no @entity854 were used as the reference group for the NCEP definition, the adjusted hazard ratio for having 3 or more abnormalities increased to 22.50 (95% CI: 11.21-45.19). Of the five components, @entity1144 and @entity4854 were most strongly associated with incident @entity6 . CONCLUSION: In this study population, both definitions of the @entity209 provided similar estimates of relative risk for incident @entity6 . The increase in risk for @entity1 with the @entity209 according to the NCEP definition was very large when contrasted with the risk among those who had no @entity854 .
