Transcranial DC stimulation in XXXX : optimized cortical target supported by high-resolution computational models.

@entity1 @entity3445 @entity239 @entity158
In this study we aimed to determine current distribution and short-term analgesic effects of transcranial direct current stimulation (tDCS) in @entity239 using different electrode montages. For each electrode montage, clinical effects were correlated with predictions of induced cortical current flow using magnetic resonance imaging-derived finite element method head model. Thirty @entity1 were randomized into 5 groups (Cathodal-M1 [primary motor cortex], Cathodal-SO [supra-orbital area], Anodal-M1, Anodal-SO, and Sham) to receive tDCS application (2 mA, 20 minutes) using an extracephalic montage. @entity158 was measured using a visual numerical scale (VNS), pressure @entity158 threshold (PPT), and a body diagram (BD) evaluating @entity158 area. There was significant @entity158 reduction in cathodal-SO and anodal-SO groups indexed by VNS. For @entity3445 there was a trend for a similar effect in anodal-SO group. Computer simulation indicated that the M1-extracephalic montage produced dominantly temporo-parietal current flow, consistent with lack of clinical effects with this montage. Conversely, the SO-extracephalic montage produced current flow across anterior prefrontal structures, thus supporting the observed analgesic effects. Our clinical and modeling findings suggest that electrode montage, considering both electrodes, is critical for the clinical effects of M1-tDCS as electric current needs to be induced in areas associated with the @entity158 matrix. These results should be taken into consideration for the design of @entity158 tDCS studies. PERSPECTIVE: Results in this article support that electrode montage is a critical factor to consider for the clinical application of tDCS for @entity158 control, as there is an important correlation between the location of induced electrical current and tDCS-induced analgesic effects.
