@entity876 Protein accumulates in @entity652 and invasive non-functional XXXX .

@entity876 @entity1 @entity652 @entity5
The @entity876 protein, a negative regulator of cell growth, plays an important role in the pathogenesis of many @entity1 @entity5 following gene mutation and/or deletion. We screened a large number of @entity5 for @entity876 protein accumulation suggestive of gene mutation. Samples were divided into benign @entity652 (n = 95) and invasive @entity5 with local or distant invasion (n = 26). All main @entity5 classes were represented. Putative @entity876 mutations were detected by immunohistochemistry on paraffin-embedded sections using polyclonal CM-1 and monoclonal DO-7 and PAb1801 antibodies. Results were compared to normal post-mortem pituitary tissue controls (n = 17). @entity876 protein accumulation was detected in invasive @entity5 (16%), but only in corticotrophinomas (2/4) and @entity5 (4/15). In non-invasive @entity652 , protein accumulation was observed only in ACTH-secreting @entity5 where 50% were positive (16/32). No protein accumulation was identified in any control tissue. These results indicate that @entity876 protein accumulation may play a role in the development of @entity652 and in the progression of @entity5 to the invasive state.
