XXXX . An immunohistochemical study of the epithelial component.

@entity5 @entity2543 @entity1352
Twenty-five @entity1352 were studied with a battery of antibodies directed against keratin and @entity2543 ( @entity2543 ). The keratin antibody MNF 116 showed reactivity in 24 @entity5 . In addition, 22 @entity5 showed reactivity with the antibody Keratin Wide Spectrum, 20 with the antibody Keratin 56, 64, and 19 with CAM 5.2. Seventeen @entity5 showed reactivity with @entity2543 . The keratin and @entity2543 reactivity was present in cells lining obvious cleft-like structures in @entity5 . In the spindle cell areas of both biphasic and monophasic @entity5 , we found clusters of a few reacting cells apparently located around small clefts. In the @entity5 , clusters of @entity5 cells reactive for both the keratins and @entity2543 were present. In conclusion, we found that proper identification of epithelial differentiation in @entity1352 is facilitated by an immunohistochemical application of anti-epithelial antibodies. In most @entity5 , there was immunoreactivity for the same type of keratins as are normally identified in simple epithelia (the antibody CAM 5.2), but also for those found in stratified squamous epithelia (the antibody Keratin 56, 64). The results indicate that screening for epithelial features on paraffin sections in the various types of @entity1352 , even the poorly differentiated @entity5 , is improved if epithelial antibodies with a broad spectrum of reactivity are chosen.
