Gamma Rhythms Link Prefrontal Interneuron Dysfunction with Cognitive Inflexibility in @entity26308 /6(+/-) XXXX .

@entity69963 @entity26308 @entity19 @entity73 @entity14978 @entity161
UNASSIGNED: Abnormalities in GABAergic interneurons, particularly fast-spiking interneurons (FSINs) that generate gamma (y;    30-120  Hz) oscillations, are hypothesized to disrupt prefrontal cortex (PFC)-dependent cognition in @entity161 . Although y rhythms are abnormal in @entity161 , it remains unclear whether they directly influence cognition. Mechanisms underlying @entity161 's typical post-adolescent onset  also remain elusive. We addressed these issues using @entity19 heterozygous for @entity69963 , which regulate GABAergic interneuron development. In @entity69963 (+/-) @entity19 , FSINs become abnormal following adolescence, coinciding with the onset of @entity73 and @entity14978 . Inhibiting PFC interneurons in control @entity19 reproduced these deficits, whereas stimulating them at y-frequencies restored @entity73 in adult @entity26308 /6(+/-) @entity19 . These pro-cognitive effects were frequency specific and persistent. These findings elucidate a mechanism whereby abnormal FSIN development may contribute to the post-adolescent onset of @entity161 endophenotypes. Furthermore, they demonstrate a causal, potentially therapeutic, role for PFC interneuron-driven y oscillations in cognitive domains at the core of @entity161 . VIDEO ABSTRACT.
