XXXX : determining the genetic profile from ultrasound-guided percutaneous biopsy specimens obtained during the diagnostic workups.

@entity5 @entity1 @entity0
OBJECTIVES: To evaluate the possibility of determining the genetic profile of primary @entity5 of the breast from specimens obtained by ultrasound-guided percutaneous biopsies during the diagnostic imaging workup. MATERIAL AND METHODS: This is a retrospective study in 13 consecutive @entity1 diagnosed with invasive @entity0 by B-mode ultrasound-guided 12 G core needle biopsy. After clinical indication, the pathologist decided whether the paraffin block specimens seemed suitable (on the basis of @entity5 size, validity of the sample, and percentage of @entity5 cells) before sending them for genetic analysis with the MammaPrint   platform. RESULTS: The size of the @entity5 on ultrasound ranged from 0.6cm to 5cm. In 11 @entity1 the preserved specimen was considered valid and suitable for use in determining the genetic profile. In 1 @entity1 (with a 1cm @entity5 ) the pathologist decided that it was necessary to repeat the core biopsy to obtain additional samples. In 1 @entity1 (with a 5cm @entity5 ) the specimen was not considered valid by the genetic laboratory. The percentage of @entity5 cells in the samples ranged from 60% to 70%. In 11/13 cases (84.62%) it was possible to do the genetic analysis on the previously diagnosed samples. CONCLUSION: In most cases, regardless of @entity5 size, it is possible to obtain the genetic profile from tissue specimens obtained with ultrasound-guided 12 G core biopsy preserved in paraffin blocks.
