Behavioral and electrophysiological recovery following cryogenic XXXX .

@entity66 @entity4 @entity8162 @entity128 @entity51 @entity5828 @entity158 @entity6441 @entity35 @entity12786 @entity130
@entity158 can be reduced by cryoanalgesia of intercostal nerves. The technique involves focal freezing of peripheral nerves to interrupt @entity158 pathways, producing immediate functional changes that recover as the nerves regenerate. To assess the time-course of functional changes that follow nerve @entity66 were induced in @entity35 with a cryosurgical unit. The contralateral nerves were used as sham-operated controls. Following @entity128 , behavioral and electrophysiologic tests were repeated to 90 days. The acute effect of @entity128 was a decrease in behavioral measures of hind limb function (P less than 0.05), an increase in electrical threshold to elicit hind limb contraction (P less than 0.005), and an absence of stimulus-evoked compound action potential (P less than 0.005). Morphologic changes included substantial endoneurial @entity4 associated with @entity6441 . Remyelination occurred subsequently during the following 35 days. Although all physiologic measures returned toward normal, nerve conduction velocities were still much slower in the experimental group. In a second study, the long-term effects of cryogenic injury were compared with @entity130 with 10% @entity8162 @entity5828 , both of which produced a conduction velocity deficit that persisted at least 90 days after the @entity130 . These behavioral and electrophysiologic results complement previous reports of morphologic @entity51 including incomplete recovery of nerve fiber diameter and increased thickness of the @entity12786 .
