Gut microbiota and diet in @entity1 with different XXXX tolerance.

@entity2175 @entity1 @entity34565 @entity3363 @entity6 @entity5710 @entity1735 @entity413
UNASSIGNED: @entity2175 ( @entity2175 ) is a serious disease. The gut microbiota has recently been identified as a new potential risk factor in addition to well-known @entity6 risk factors. To investigate the gut microbiota composition in association with the dietary patterns in @entity1 with different @entity413 tolerance we analyzed 92 @entity1 : with normal @entity413 tolerance (n=48), @entity5710 ( @entity5710 , n=24), @entity2175 (n=20). Metagenomic analysis was performed using 16SrRNA sequencing. The diet has been studied by a frequency method with a quantitative evaluation of food intake using a computer program. Microbiota in the samples was predominantly represented by Firmicutes, in a less degree by Bacteroidetes. Blautia was a dominanting genus in all samples. The representation of Blautia, @entity34565 was lower in @entity5710 than in @entity2175 @entity1 , and even lower in those with normal @entity413 tolerance. After the clustering of the samples into groups according to the percentage of protein, fat, @entity3363 in the diet, the representation of the Bacteroides turned to be lower and Prevotella abundance turned to be higher in @entity1735 cluster. There were more @entity1 with insulin resistance, @entity2175 in the fat-protein cluster. Using the Calinski-Harabasz index identified the samples with more similar diets. It was discovered that half of the @entity1 with a high-fat diet had normal tolerance, the others had @entity2175 . The regression analysis showed that these @entity2175 @entity1 also had a higher representation of Blautia. Our study provides the further evidence concerning the structural modulation of the gut microbiota in the T2DM pathogenesis depending on the dietary patterns.
