XXXX in a Boxer.

@entity1087 @entity706 @entity235 @entity229 @entity784 @entity11770 @entity1503 @entity14427 @entity56 @entity272 @entity491
UNASSIGNED: A 7-year-old male Boxer with a 3.5-year history of @entity56 was presented with multiple poorly circumscribed nodules and maculae of the skin and tongue, and @entity1087 . Cytologic and histopathologic examination of the @entity272 revealed @entity706 . Cells were CD3(+) and CD8(+) in flow cytometry. The CBC showed a moderate @entity491 with 16% atypical lymphocytes with irregularly cleaved nuclei. Flow cytometric phenotyping of peripheral blood showed an elevated proportion of the CD8(+) T-lymphocyte subpopulation, indicating a malignant population of T-cell origin, and the electropherogram of the PCR antigen receptor rearrangement produced a monoclonal peak for TCRy. Liver enzyme activities were markedly increased and abdominal ultrasound examination showed increased echogenicity of the liver and enlarged abdominal lymph nodes. Fine-needle aspirates of the liver confirmed infiltration with lymphocytes exhibiting the same morphology as the cells detected in skin and peripheral blood. Treatment was induced with @entity14427 , @entity11770 , and @entity229 . Partial clinical remission of the @entity272 was achieved within 10  days, and @entity1503 resolved. Despite further treatment with @entity14427 and @entity11770 , the @entity235 relapsed within one  month and was euthanized. Presence of malignant lymphocytes in skin, peripheral blood, and liver indicate a rare variant of leukemic @entity784 , equivalent of S  zary syndrome in a @entity235 . This case report describes the use of flow cytometry as a complementary tool for lymphocyte characterization of @entity272 for the first time.
