Early XXXX viewed from its growth patterns.

@entity308 @entity5 @entity1066 @entity189 @entity356
In investigations of the natural history of @entity356 , the following conclusions were drawn. There are at least two types of @entity356 --a rapidly growing penetrating @entity5 (Pen) and a slowly growing superficial type (Super). The Super-type @entity5 are predominately @entity308 and are associated with favorable prognosis. A subtype of @entity5 , Pen A, is characterized by an elevated lesion and by differentiated @entity189 ; its @entity5 has a less favorable prognosis than a Pen @entity5 . The @entity5 ideally should be treated at the intramucosal stage. A @entity5 can be differentiated by cytophotometric DNA analysis. It seems that the @entity5 progresses to the funnel-shaped, non-Borrmann advanced type of @entity5 of a lesser incidence, and the Pen type leads to the most advanced @entity5 of Borrmann type. Low ploidy DNA patterns are seen in Super- and @entity5 , while @entity5 is featured by the high ploidy pattern. A slowly growing @entity5 is more likely to be detected because it remains at the early stage for a longer period. Conversely, the rapidly growing @entity5 is less likely to be detected until the @entity5 has reached an advanced stage. @entity1066 symptoms accompanied by the Super type seem to create a detection bias, and the chance of @entity5 detection is increased. A rough estimation of the occurrence rate of slowly and rapidly growing @entity5 is about 1:2. The frequent occurrence of slowly growing @entity5 seems to be characteristic of a @entity356 , as such is not likely the case with @entity5 seen elsewhere in the GI tract. We have to direct considerable efforts to studies of rapidly growing @entity356 ; the early detection of @entity5 will be a top priority study in this field. The focus of inspection should be directed to differentiation of "type-oriented @entity5 ." Nearly 20 years ago we first proposed the concept of the Pen type of early @entity356 . At that time relatively few investigators seemed to accept our view. However, understanding has gradually increased and infiltrated among Japanese researchers. The Japanese experience with @entity356 has been thought to be singular because of the high rate of detection of early @entity356 in these two decades.(ABSTRACT TRUNCATED AT 400 WORDS)
