Association of @entity1561 with impaired endothelial function by flow-mediated XXXX : A meta-analysis.

@entity1 @entity384 @entity409 @entity7936 @entity1507 @entity1561 @entity731
AIM: Endothelial dysfunction was observed in @entity1 with @entity1561 . The aim of the present study was to evaluate the extent of endothelial function impairment in @entity1 with @entity1561 . METHODS: We systematically searched through the PubMed, Embase, China National Knowledge Infrastructure and Wanfang databases for studies dated up to January 2015. All observational studies that compared endothelial function between @entity1561 @entity1 and healthy controls were included. Endothelial function was measured by brachial artery flow-mediated @entity384 and @entity1507 -induced dilatation techniques. RESULTS: Eleven observational studies were identified. Meta-analysis indicated that @entity1561 @entity1 were associated with a reduction in brachial artery flow-mediated @entity384 (weighted mean difference, -4.82%; 95% confidence interval [CI], -5.63 to -4.00) compared with the healthy controls. Subgroup analysis indicated that the @entity1 with @entity7936 or a body mass index of more than 30   kg/m(2) appeared to have a greater reduction in their flow-mediated @entity384 . However, no significant differences were observed in the @entity1507 -induced @entity384 (weighted mean difference, -0.4%; 95% confidence interval, -2.19 to 1.39). CONCLUSION: @entity1561 is associated with a greater risk of @entity409 as indicated by the decreased brachial artery flow-mediated @entity384 . Assessment of endothelial function may be recommended to identify subclinical @entity731 and to create subgroups of @entity1561 @entity1 who are at higher risk of future cardiovascular events.
