Changes in markers of oxidative status in brain, liver and kidney of young and aged XXXX following exposure to aromatic white spirit.

@entity308 @entity1160 @entity10519 @entity409 @entity2041 @entity35
Levels of @entity2041 and activity of @entity1160 synthetase were assayed in organs of @entity35 following inhalation of a heterogeneous solvent mixture containing both aliphatic and @entity10519 . This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult (5-month-old) and aged (14-month-old) @entity35 . @entity308 of levels of @entity1160 synthetase in the P2 fraction of kidney was observed, which was more severe in aged than young adult @entity35 . @entity1160 synthetase is a cytosolic enzyme especially susceptible to oxidative damage. A parallel @entity308 of this enzyme was also seen in the corresponding hepatic fractions. However, levels of @entity1160 synthetase in the hippocampus were elevated by this exposure. @entity2041 levels were @entity308 in P2 fractions of livers of exposed @entity35 , and also in the corresponding renal fraction. @entity2041 concentration was unchanged in cerebral fractions. Overall results were interpreted to imply that pro-oxidant events were @entity409 following prolonged inhalation of the solvent mixture. The changes found in brain tissue did not reveal evidence of oxidative stress but, however, suggested that glial activation was taking place.
