Value of oral effervescent powder administration for multidetector CT evaluation of XXXX .

@entity1 @entity5 @entity2286 @entity418
PURPOSE: To assess the value of oral effervescent powder (EP) for evaluation of esophageal distension, and for detection and staging of @entity418 with contrast-enhanced CT. MATERIALS AND METHODS: 84 @entity1 without esophageal pathology and 52 @entity1 with histological confirmed diagnosis of @entity418 were included in this prospective IRB-approved study. Half of the @entity1 in both groups received EP prior to CT. Esophageal distension was assessed by planimetry of the inner (IA) and outer area (OA). Two blinded readers evaluated the datasets separately with regard to diagnosis of @entity418 (yes/no) and staging (T0-T4), if applicable. Distension results were compared (t-Test). In @entity1 with @entity5 sensitivity, specificity, NPV and @entity2286 were calculated. CT staging results were compared to histopathology (Cohen-k). RESULTS: IA and IA/OA were significantly larger after EP as compared to the group without EP (p<0.05). Sensitivity, specificity, NPV and @entity2286 for @entity5 detection @entity5 were as follows: 78%/78%, 98%/98%, 95%/95%, 87%/87% with EP; 60%/68%, 98%/98%, 94%/94%, 80%/83% without EP. Staging with EP was good (k=0.84/0.67) and moderate without EP (k=0.58/0.59). CONCLUSIONS: Administration of EP prior to CT results in good distension of the esophagus, and improves detection and staging of @entity418 , as compared to control studies without EP.
