Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in XXXX detection.

@entity1 @entity227 @entity1538 @entity101 @entity726 @entity9999 @entity194
PURPOSE: The aim of this study was to evaluate the diagnostic usefulness of the combined use of frequency-doubling technology (FDT) perimetry and polarimetry of the retinal nerve fiber layer. DESIGN: Cross-sectional study. METHODS: Seventy ocular @entity101 @entity1 (normal optic disk and standard perimetry, elevated intraocular pressure [>21 mm Hg]), 59 @entity1 with "preperimetric" @entity1538 (glaucomatous optic disk @entity194 , elevated intraocular pressure [>21 mm Hg], no @entity227 in standard perimetry), 105 @entity1 with "perimetric" @entity1538 (glaucomatous optic disk @entity194 and clearly marked @entity227 ), and 73 control subjects had FDT screening (protocol: C-20-5) and polarimetric measurements ( @entity9999 ). Criteria for exclusion: optic disks larger than 4 mm(2), media opacities, @entity1 younger than 33 years or older than 66 years. None of the subjects had earlier FDT perimetry. One eye of each @entity1 and control subject entered the statistical evaluation. Database and statistical software were used for case-wise recalculation of all missed localized probability levels to create a FDT screening score. RESULTS: At a predefined specificity of 94.5% in control eyes, discrimination between "perimetric" @entity726 and normal subjects is superior using the FDT perimetry (sensitivity = 84.8%) in comparison to polarimetry (sensitivity = 63.8%), whereas sensitivity is similar with both methods in "preperimetric" @entity1 ( @entity9999 , FDT: 25.4%). In several cases, @entity1 classified as glaucomatous by the @entity9999 are not the same @entity1 as identified by the FDT perimetry. Therefore, a two-dimensional discrimination analysis can increase correct positive classification. Using a linear combination of the present FDT screening score and polarimetry ("the number"), 92.4% of "perimetric" @entity726 and 44.1% of "preperimetric" @entity726 have been classified as glaucomatous. CONCLUSION: Joint usage of polarimetry and FDT perimetry indicate that a combination of different techniques which can uncover different @entity726 properties, might be helpful in early @entity726 detection.
