Esophageal motility after peroral endoscopic myotomy for XXXX .

@entity1318 @entity1 @entity28224 @entity1282
BACKGROUND: Peroral endoscopic myotomy (POEM) has been introduced as a novel endoscopic treatment for @entity1318 . The aim of this work is to assess the changes in esophageal motility caused by POEM in @entity1 with @entity1318 . METHODS: Forty-one @entity1 with @entity1318 underwent POEM from September 2012 to November 2014. Esophageal motility of all @entity1 was evaluated preoperatively and 1  month after POEM utilizing high-resolution manometry, which was performed with ten water swallows, ten steamed bread swallows, and @entity1282 ( @entity1282 ). RESULTS: In single swallows, including liquid swallows and bread swallows, all the parameters of lower esophagus sphincter resting pressure (LESP), 4-s integrated relaxation pressure (4 @entity28224 ), and intra-bolus pressure (IBP) were decreased between pre- and post-POEM @entity1 (all p  <  0.05). Postoperatively, the trend of distal contractile integral (DCI) and distal esophageal peristaltic amplitude declined in subtype II and subtype III (subtype II: p  <  0.05; subtype III: p  >  0.05), but increased in subtype I (subtype I: p  >  0.05). In liquid swallows, the Eckardt score of subtype II @entity1 decreased with DCI, and distal esophageal peristaltic amplitude after POEM was significantly lower compared with those showing increased values of those two parameters (p  <  0.05). In @entity1282 , the rate of LES relaxation increased from 66.67 to 95.24  %, but without normal response in all @entity1318 @entity1 . CONCLUSIONS: POEM reduces LES pressure in @entity1318 , and partly restores esophageal motility. POEM displayed varying effect on esophageal motility in @entity1 with different patterns of swallowing. In addition, the changes in parameters associated with esophageal peristalsis correlated with decreases in Eckardt score.
