Neuroprotective strategies for basal ganglia degeneration: XXXX .

@entity179 @entity2359 @entity2033
There are three main mechanisms of neuronal cell death which may act separately or cooperatively to cause @entity179 . This lethal triplet of metabolic compromise, excitotoxicity, and oxidative stress causes neuronal cell death that is both necrotic and apoptotic in nature. Aspects of each of these three mechanisms are believed to play a role in the @entity179 that occurs in both @entity2033 . Strategies to rescue or protect injured neurons usually involve promoting neuronal growth and function or interfering with @entity2359 processes. Considerable research has been done on testing a large array of neuroprotective agents using animal models which mimic these disorders. Some of these approaches have progressed to the clinical arena. Here, we review neuroprotective strategies which have been found to successfully ameliorate the @entity179 associated with @entity2033 . First, we will give an overview of the mechanisms of cell death and the background of @entity2033 . Then we will elaborate on a range of neuroprotective strategies, including neurotrophic factors, anti-excitotoxins, antioxidants, bioenergetic supplements, anti-apoptotics, immunosuppressants, and cell transplantation techniques. Most of these approaches hold promise as potential therapies in the treatment of these disorders.
