Pathologic and clinical features of XXXX .

@entity154 @entity712 @entity339 @entity295 @entity39 @entity75 @entity262 @entity886 @entity475 @entity397 @entity337 @entity179 @entity4461 @entity1188 @entity340 @entity943 @entity166 @entity2259
@entity166 is a @entity262 associated with high morbidity and mortality. Clinical recognition and effective management is challenging, but insights can be gleaned from relevant pathologic features. Risk factors include @entity475 , possibly certain other @entity154 , and @entity2259 . Auscultation can provide clues regarding valvular involvment, particularly when a diastolic left basilar murmur of @entity337 is present. @entity886 and insufficiency may also alter femoral arterial pulse characteristics. Echocardiography may facilitate diagnosis, particularly with @entity886 , but may not be able to distinguish between small @entity339 and early chronic @entity179 . @entity75 develop along edges of valve closure on the ventricular aspect of the aortic valve and the atrial surface of @entity340 . They may extend across valve leaflet, from valves to adjacent left atrial endocardium, interventricular or interatrial septum, or chordae tendineae. Vegetations can be friable and frequently embolize to spleen, kidney, and left ventricle - often before clinical recognition of the disease. @entity340 develops as a consequence of @entity340 , @entity39 , perforation, or @entity397 of the chordae tendineae. Histopathologic appearance varies with respect to duration of disease and antimicrobial therapy. These factors influence the amount of @entity39 material, @entity4461 , fibrin, and inflammatory cells which make up the vegetations. Bacteria are not always identified in @entity340 , especially following antibacterial therapy, but may be detected in other organs. Common sequellae include @entity712 , @entity295 , @entity943 , and systemic organ @entity1188 .
