Diagnostic value of MRI proton density fat fraction for assessing XXXX in chronic @entity10745 .

@entity1 @entity10745 @entity1560
Objective. To assess the diagnostic performance of a T1-independent, T2(*)-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of @entity1560 in a cohort of @entity1 affected by chronic @entity10745 , using liver biopsy as gold standard. Methods. Eighty-one untreated @entity1 with chronic @entity10745 were prospectively enrolled. All included @entity1 underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 @entity1 included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31    11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2(*) decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S >=  1 and 0.929 (95% CI 0.847 to 0.975) for S = 2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of @entity1560 .
