A Pyrosequencing Investigation of Differences in the Feline Subgingival Microbiota in Health, XXXX and Mild @entity2521 .

@entity1 @entity527 @entity235 @entity2522 @entity2521 @entity468
@entity2521 is the most frequently diagnosed health problem in @entity468 yet little is known about the bacterial species important for the disease. The objective of this study was to identify bacterial species associated with health, @entity2522 or mild @entity2521 (<25% attachment loss) in feline plaque. Knowledge of these species is a first step in understanding the potential for improving oral health of @entity468 via dietary interventions that alter the proportions of influential species. @entity527 samples were collected from 92 @entity468 with healthy gingiva, @entity2522 or mild @entity2521 . Pyrosequencing of the V1-V3 region of the 16S rDNA from these plaque samples generated more than one million reads and identified a total of 267 operational taxonomic units after bioinformatic and statistical analysis. Porphyromonas was the most abundant genus in all gingival health categories, particularly in health along with Moraxella and Fusobacteria. The Peptostreptococcaceae were the most abundant family in @entity2522 and mild @entity2521 . Logistic regression analysis identified species from various genera that were significantly associated with health, @entity2522 or mild @entity2521 . The species identified were very similar to those observed in @entity235 plaque in the corresponding health and disease states. Such similarities were not observed between cat and @entity1 at the bacterial species level but with disease progression similarities did emerge at the phylum level. This suggests that interventions targeted at @entity1 pathogenic species will not be effective for use in @entity468 but there is more potential for commonalities in interventions for @entity468 and @entity235 .
