Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and XXXX with @entity15 .

@entity1 @entity10368 @entity1010 @entity15882 @entity15
BACKGROUND: Whole @entity1010 is a putative outcome measure in monitoring relapsing-remitting @entity15 (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in @entity15 and normal controls (NC). METHODS: We studied @entity15 [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized @entity15882 from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations. RESULTS: @entity10368 .5T was higher than @entity10368 T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. @entity10368 T showed a larger volume decrease and larger effect size in detecting @entity1010 in @entity15 versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to @entity10368 .5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between @entity10368 .5T and EDSS (r = -.43, P = .027) and @entity10368 T and EDSS (r = -.49, P = .011) and between @entity10368 .5T and T25FW (r = -.46, P = .018) and @entity10368 T and T25FW (r = -.56, P = .003) slightly favored 3T. @entity15882 -cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53). CONCLUSIONS: Field strength may impact whole brain volume measurements in @entity1 with @entity15 though the differences are not too divergent between 1.5T and 3T.
