A randomised study comparing the effect on ovarian activity of a progestogen-only pill (POP) containing XXXX and a new POP containing @entity4863 in a 24/4 regimen.

@entity172 @entity548 @entity1420 @entity4863 @entity53 @entity7281 @entity2670
UNASSIGNED: Objectives Progestogen-only pills (POPs) are safer with respect to cardiovascular risks than contraceptives containing @entity172 . Despite the increased contraceptive efficacy of a @entity7281 -only pill compared with a traditional POP, POPs are still not widely used due to an unpredictable @entity548 pattern. A new POP containing 4 mg @entity4863 has been developed with a 24/4 intake regimen which may improve the @entity548 pattern. The objectives of this study were to investigate ovulation inhibition with the new @entity4863 -only pill in comparison with the @entity7281 -only pill and, in addition, to assess the effects on cervical mucus permeability and @entity548 . Methods Sixty-four healthy volunteers with proven ovulatory cycles were randomised and treated with either the @entity4863 -only or the @entity7281 -only pill during two 28-day cycles. Follicular diameter, endometrial thickness, and serum @entity53 (E2) and @entity1420 concentrations were measured and Hoogland scores were determined. Additionally, cervical mucus scores, @entity548 and return of ovulation were assessed. Results Both treatments effectively inhibited ovulation. Follicular diameter, E2 levels and Hoogland scores were equal, demonstrating @entity2670 . One subject in each group had a Hoogland score of 6, but the criteria for normal luteal activity were not fulfilled. In both groups, ovulation did not occur before day 9 of the post-treatment cycle. Cervical mucus permeability was suppressed in both groups. The median number of @entity548 and spotting days was lower in the @entity4863 group. Conclusions The new @entity4863 -only pill inhibited ovulation as effectively as the @entity7281 -only pill despite the 4-day hormone-free interval.
