Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy for XXXX : A Meta-Analysis of Randomized Controlled Trials.

@entity1 @entity353 @entity1103 @entity299 @entity1020
OBJECTIVE: To evaluate the relative efficacy of ranibizumab (RBZ) monotherapy or combined with laser (RBZ + Laser) versus laser monotherapy for the treatment of @entity1103 ( @entity1103 ). METHODS: A comprehensive literature search using PUBMED, ClinicalTrials.gov, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing RBZ or RBZ + Laser to laser monotherapy in @entity1 with @entity1103 . Efficacy estimates were determined by comparing @entity353 ( @entity353 ) in the change of best corrected visual acuity (BCVA) and @entity1020 ( @entity1020 ) from baseline, and the risk ratios (RR) for the proportions of @entity1 with at least 15 letters change from baseline. Safety analysis estimated the RR of @entity299 at 6 to 12 months in RBZ therapy vs. laser monotherapy. Statistical analysis was performed using the RevMan 5.1 software. RESULTS: Seven RCTs were selected for this meta-analysis, including 1749 @entity1 (394 @entity1 in the RBZ group, 642 @entity1 in the RBZ + Laser group, and 713 @entity1 in the laser group). RBZ and RBZ + Laser were superior to laser monotherapy in the mean change of BCVA and @entity1020 from baseline ( @entity353 =5.65, 95% confidence interval (CI), 4.44-6.87, P<0.00001; @entity353 =5.02, 95% CI, 3.83-6.20, P<0.00001, and @entity353 =-57.91, 95% CI, -77.62 to -38.20, P<0.00001; @entity353 =-56.63, 95% CI, -104.81 to -8.44, P=0.02, respectively). The pooled RR comparing the proportions of @entity1 with at least 15 letters improvement or deterioration were also in favor of RBZ and RBZ + Laser (RR=2.94, 95% CI, 1.82-4.77, P<0.00001; RR=2.04, 95% CI, 1.50-2.78, P<0.00001, and RR=0.21, 95% CI, 0.06-0.71, P=0.01; RR=0.52, 95% CI, 0.29-0.95, P=0.03, respectively). There were no significant differences between RBZ and RBZ + Laser for any of the parameters. There were no difference in the safety profile between RBZ and laser. CONCLUSION: RBZ and RBZ + Laser had better visual and anatomic outcomes than laser monotherapy in the treatment of @entity1103 . RBZ + Laser seemed to be equivalent to RBZ.
