Different patterns of spontaneous brain activity between @entity400 and postural instability/gait difficulty subtypes of XXXX : a resting-state fMRI study.

@entity1 @entity3034 @entity191 @entity400 @entity4365 @entity1344
AIMS: @entity1344 ( @entity1344 ) and @entity400 ( @entity400 ) subtypes of @entity191 ( @entity191 ) show different clinical manifestations; however, their underlying neural substrates remain incompletely understood. This study aimed at investigating the subtype-specific patterns of spontaneous brain activity in @entity191 . METHODS: Thirty-one @entity1 with @entity191 (12 @entity400 /19 @entity1344 ) and 22 healthy gender- and age-matched controls were recruited. Resting-state functional magnetic resonance imaging data were collected, and @entity4365 ( @entity4365 ) was measured. Voxelwise one-way analysis of covariance and post hoc analyses of @entity4365 were performed among the three groups, with age and gender as covariates ( @entity3034 daily dosage and gray matter volume as additional covariates for validation analysis). Correlations of clinical variables (e.g., disease duration and @entity1344 / @entity400 subscale score) with @entity4365 values were examined. RESULTS: Compared with controls, @entity1 with @entity400 exhibited higher @entity4365 in the right cerebellar posterior lobe and @entity1 with @entity1344 exhibited lower @entity4365 in the bilateral putamen and cerebellar posterior lobe, and higher values primarily in several cortical areas including the inferior and superior temporal gyrus, superior frontal, and parietal gyrus. Compared with @entity1 with @entity1344 , @entity1 with @entity400 had higher @entity4365 in the bilateral putamen and the cerebellar posterior lobe, as well as lower @entity4365 in the bilateral temporal gyrus and the left superior parietal lobule. In all @entity1 , @entity4365 in the bilateral cerebellar posterior lobe positively correlated with @entity400 score and @entity4365 in the bilateral putamen negatively correlated with @entity1344 score. CONCLUSION: Different patterns of spontaneous neural activity in the cerebellum and putamen may underlie the neural substrate of @entity191 motor subtypes.
