Cytodiagnosis of epithelioid malignant XXXX (amelanotic) and diagnostic dilemmas.

@entity1 @entity2283 @entity242 @entity5 @entity5701 @entity189 @entity3059 @entity1893 @entity320
@entity320 is an aggressive @entity5 , and early diagnosis can reduce mortality in such @entity1 . Diagnosis may be delayed in @entity5 . We present one such case, a 35-year-old lady with a rapidly growing mass over the right angle of mandible. Fine-needle aspiration cytology was done, and smears showed discretely arranged large epithelioid cells with high N:C ratio, prominent single to multiple nucleoli. Occasional binucleated and multinucleated @entity5 giant cells were also noted. Poorly differentiated @entity189 , high-grade @entity1893 , @entity5701 , and @entity242 were included as differential diagnoses. Immunocytochemistry (ICC) revealed Melan-A/ @entity3059 positivity in some cells and S-100 positivity in most @entity5 cells. @entity2283 , pancytokeratin, and leukocyte common antigen were negative. Based on cytomorphological features and ICC findings, a diagnosis of epithelioid variant of @entity5701 was rendered. Later on, true cut biopsy and histologic examination of excised specimen and adjunct immunohistochemistry with positive Melan-A and S-100 confirmed the diagnosis.
