Targeting @entity19562 and its dependence receptor XXXX kinase receptor C: a new antitumoral strategy.

@entity19562 @entity5 @entity13820 @entity521 @entity669 @entity734
INTRODUCTION: @entity13820 ( @entity13820 ) is a neurotrophin receptor that belongs to the @entity669 kinase receptor family. This family primarily consists of proto-oncogenes, and @entity13820 has been involved in oncogenic translocations. However, its expression in @entity5 is often associated with good prognosis, suggesting it actually acts as a @entity5 suppressor. @entity13820 has recently been demonstrated to be a dependence receptor, which regulates neuronal survival. @entity734 receptors share the ability to trigger apoptosis in the absence of their ligand, a feature that has been suggested to confer a @entity5 suppressor function to these receptors. A selective advantage for a @entity5 cell to survive in an environment with limited ligand availability would hence be either to lose the expression of the dependence receptor, or to gain expression of its ligand. AREAS COVERED: The role of @entity19562 ( @entity19562 ) and its dependence receptor @entity13820 in @entity521 , and its suitability as a therapeutic target. EXPERT OPINION: Autocrine production of @entity19562 represents a selective advantage for @entity5 growth and dissemination, in a large fraction of aggressive @entity521 . Disruption of the @entity19562 autocrine loop in malignant neuroblasts, triggers @entity521 cell death, and @entity521 metastasis in animal models. Thus, a novel way of targeting the @entity669 kinase receptor, is via the reactivation of its intrinsic ability to trigger cell death.
