Offline exhaled nitric oxide in emergency department and subsequent XXXX control.

@entity748 @entity1 @entity697 @entity565 @entity134 @entity2263
BACKGROUND: Few studies have evaluated exhaled NO measurement during @entity697 . OBJECTIVES: To evaluate exhaled NO fraction (FE(NO)) and peak expiratory flow (PEF) time-courses during @entity697 treatment ( @entity2263 -agonist plus systemic @entity134 ) and to assess whether FE(NO) time-course predicts subsequent @entity565 control. METHODS: Sixty-five @entity748 @entity1 (mean +/- SD, 34 +/- 10 years) were prospectively enrolled in three Emergency Departments. RESULTS: Sixteen @entity1 were excluded (failure of offline FE(NO) measurement at 100 mL/s [FE(NO 0.1)], n = 4, and early discharge). The 49 remaining @entity1 performed FE(NO 0.1) and PEF on admission, at the 2nd (H2) and 6th hour (H6). Follow-up using an Asthma Control Diary was obtained in 27 of 49 @entity1 , whether they were hospitalized (n = 9) or discharged (n = 18). All but 2 @entity1 had elevated FE(NO) on admission (median [interquartile], 49 [26-78] ppb). Unlike PEF, mean FE(NO 0.1) of our sample was not significantly modified by treatment. No significant relationship was evidenced between exhaled NO and PEF variations. The variation of FE(NO 0.1) [H0 minus H6] was different in @entity1 who were hospitalized (decrease of 8 +/- 20 ppb) versus discharged (increase of 5 +/- 20 ppb, p = 0.04). This variation of FE(NO 0.1) was correlated with the Diary score (control of subsequent week), an initial increase in FE(NO 0.1) being associated with better @entity565 control. Nevertheless, neither exhaled NO nor PEFR were good predictors of @entity565 control. CONCLUSIONS: An increase in FE(NO) is observed in almost all @entity1 with @entity697 , and its subsequent increase within 6 hours is associated with a better degree of @entity565 control in the subsequent week.
