Effects of Aerobic Training on Cognition and Brain @entity413 Metabolism in Subjects with Mild XXXX .

@entity1 @entity11509 @entity419 @entity73 @entity26 @entity411 @entity413
BACKGROUND: @entity411 ( @entity411 ) is a promising intervention for @entity73 ( @entity73 ). OBJECTIVE: To evaluate the effects of @entity411 on cognition and regional brain @entity413 metabolism (rBGM) in @entity73 @entity1 . METHODS: Subjects performed a twice-a-week, moderate intensity, @entity411 program for 24 weeks. Assessment with @entity11509 -cog, a comprehensive neuropsychological battery, and evaluation of rBGM with positron emission tomography with @entity419 ( @entity419 -PET) were performed before and after the intervention. Aerobic capacity was compared using the maximal @entity26 consumption VO2max (mL/Kg/min). @entity419 -PET data were analyzed on a voxel-by-voxel basis with SPM8 software. RESULTS: Forty subjects were included, with a mean (M) age of 70.3 (5.4) years and an initial Mini-Mental State Exam score of 27.4 (1.7). Comparisons using paired t-tests revealed improvements in the @entity11509 -cog (M difference: -2.7 (3.7), p< 0.001) and VO2max scores (M difference: 1.8 (2.0) mL/kg/min, p< 0.001). Brain metabolic analysis revealed a bilateral decrease in the rBGM of the dorsal anterior cingulate cortex, pFWE=0.04. This rBGM decrease was negatively correlated with improvement in a visuospatial function/attentional test (rho=-0.31, p=0.04). Several other brain areas also showed increases or decreases in rBGM. Of note, there was an increase in the retrosplenial cortex, an important node of the default mode network, that was negatively correlated with the metabolic decrease in the dorsal anterior cingulate cortex (r=-0.51, p=0.001). CONCLUSION: @entity411 improved cognition and changed rBGM in areas related to cognition in subjects with @entity73 .
