[Evaluation of an immunological test for detecting occult fecal blood for case-finding in XXXX ].

@entity1 @entity1127 @entity5 @entity14 @entity652
Screening for @entity14 ( @entity5 and @entity1127 ) by searching for blood in stools using the gaiac test is a well-known method. We evaluated a new gaiac test, the originality of which from its coupling with an enzyme immuno-assay specifically measuring @entity1 hemoglobin (Fecatest). The objectives of this new test were to decrease false positives and thus to improve the positive predictive value of screening. Subjects over 45 years of age attending health examinations at a Center of Preventive Medicine were studied. Of the 5,185 subjects who received the test, 4,376 (84 p. 100) performed it correctly, demonstrating good compliance in this population. For 664 (15 p. 100), the results of the gaiac test were positive. This positivity rate was higher for @entity1 than for @entity1 (20 p. 100 vs. 10 p. 100) but was not influenced by age. After positive results, 471 (70 p. 100) @entity1 completed investigations decreasing the overall compliance to 80 p. 100. Fifteen cases of @entity5 and 78 cases of @entity652 were found. The positive predictive value of the test was 20 p. 100 for @entity5 . A benign cause was found in 44 p. 100 of 471 @entity1 , and investigations were negative in 36 p. 100. When the gaiac test was positive, the immunoenzymatic method significantly improved the positive predictive value for @entity5 (6 p. 100 vs. 3 p. 100) but not for @entity1127 (20 p. 100 vs. 17 p. 100). Three of the 15 @entity5 and half of the 78 @entity652 would not have been discovered with the immunoenzymatic method.(ABSTRACT TRUNCATED AT 250 WORDS)
