Autologous Conditioned Serum as a Novel Alternative Option in the Treatment of XXXX : A Prospective Study.

@entity1 @entity1193 @entity1192 @entity158 @entity717 @entity614
STUDY DESIGN: The study was conducted on @entity1 who received autologous conditioned serum (ACS) as a line of treatment at the Orthopedics outpatient department of Post Graduate Institute of Medical Education and Research (PGIMER, Chandigarh) from January 2011 to June 2012. Of the 1,224 @entity1 , 20 males or females were included in the study based on the inclusion and exclusion criteria. The institutional board of PGIMER approved the study before it was initiated. PURPOSE: To study the efficacy of ACS in the treatment of @entity614 . OVERVIEW OF LITERATURE: @entity1192 appears to be of special importance among the cytokines identified in orthopedic diseases. ACS contains high concentrations of @entity1193 , antagonist to IL-1 in that is a biochemical 'sensitizer' of nerve roots in @entity614 . METHODS: We included 20 @entity1 with @entity614 after obtaining informed consent. We prepared ACS as described by Meijer et al. Under bi-planar fluoroscopic imaging in anterior-posterior and lateral views, ACS was administered via epidural perineural technique. @entity1 in both groups were evaluated by quadruple visual analogue scale, straight leg raising test, revised @entity717 index, and 12-Item Short Form of Health Survey before and after epidural injections at 3 weeks, 3 months, and 6 months. RESULTS: There was a statistically significant change in all parameters from pre-injection to first, second, and third follow-up (p<0.001). CONCLUSIONS: ACS can modify the disease course in addition to reducing @entity158 , disability and improving general health.
