Comparison analysis in synchronous and metachronous metastatic XXXX based on microarray expression profile.

@entity8945 @entity5 @entity75 @entity7542 @entity9859 @entity1912 @entity4493 @entity71561 @entity63043 @entity46359 @entity3 @entity14 @entity10241 @entity2247 @entity3840
BACKGROUND/AIMS: @entity14 ( @entity14 ) is one of the most common @entity5 , and liver @entity3 is one of the major causes of death of @entity14 . This study aimed to compare the genetic difference between metachronous lesions (MC) and @entity75 ( @entity75 ) and explore the molecular pathology of @entity14 @entity3 . METHODOLOGY: Microarray expression profile data (GSE10961) including 8 MC and 10 @entity75 was downloaded from Gene Expression Omnibus. The differentially expressed genes (DEGs) between the two groups were identified based on T test. Furthermore, GO enrichment analysis was performed for the down-regulated DEGs using DAVID. Finally, Classify validation of known @entity14 genes based on previous studies between MC and @entity75 samples was conducted. RESULTS: Total of 36 DEGs including 35 down-regulated DEGs and 1 up-regulated DEGs were identified. The expressional differences of the 5 informative oncogenes: EGFr, @entity10241 , @entity3840 ( @entity2247 ), @entity7542 ( @entity9859 ), and @entity1912 between @entity75 and MC were really tiny. CONCLUSIONS: Some DEGs, such as @entity46359 , @entity4493 , @entity63043 , @entity71561 and @entity8945 might play crucial roles in the regulation of @entity14 @entity3 (both @entity75 and MC) and by disrupting some pathways. However, our results indeed demand further research and experiment.
