[Association between the polymorphism of GNB3C825T gene and XXXX in @entity1 ].

@entity1 @entity135 @entity907 @entity14643 @entity1163
OBJECTIVE: Investigate the association between GNB3C825T gene polymorphism and pediatric @entity907 . METHOD: Syncope group consisted of 54 cases of unexplained @entity1163 in @entity1 , including 18 males and 36 females, at the age of 11.8 years; control group consisted of 54 healthy @entity1 over the same period, of whom 20 were male and 34 female, at the age of 11.2 years. The @entity1 underwent @entity135 ( @entity135 ). According to @entity135 test results, @entity135 -positive group and @entity135 -negative group were further classified. For cases in @entity135 -positive group, based on the changes in blood pressure and in heart rate during @entity135 , vasodepressor, mixed and cardioinhibitory patterns were studied. DNA was extracted from peripheral blood in all the @entity1 . A pair of primers was designed flanking 825 polymorphic loci. Products were recovered by using polymerase chain reaction (PCR). GNB3 @entity14643 polymorphism was detected by using gene-side GNB3C825T sequencing. Allele distribution between the various groups were studied. RESULT: Among fifty-four @entity1 with @entity1163 , @entity135 was positive in 30 cases, including vasodepressor pattern in 15 cases (50.0%), mixed pattern in 9 cases (30.0%) and cardioinhibitory pattern in 6 cases (20.0%). Whereas the subjects in control group had negative @entity135 response. GNB3C825T allele C in the control and @entity1163 groups was 81.5% and 65.7%, respectively. GNB3C825T allele T in the control and @entity1163 groups was 18.5% and 34.3%, respectively (  (2) = 6.888, P < 0.05). GNB3C825T allele C in @entity135 -positive and negative groups was 61.7% and 81.3%, respectively. And GNB3C825T allele T in @entity135 -positive and negative groups was 38.3% and 18.7%, respectively (  (2) = 4.905, P < 0.05). GNB3C825T allele frequency did not show statistically significant difference among the 3 hemodynamic patterns of VVS (  (2) = 0.658, P > 0.05). CONCLUSION: Study on GNB3C825T allele frequency in @entity1 with @entity907 is of significant value for a better understanding of the pathophysiology of VVS and provide a molecular biologic basis for its mechanisms.
