Pathological characterization of primary splenic myxoid liposarcomas in three XXXX .

@entity38630 @entity242 @entity11691 @entity235 @entity5 @entity1579 @entity3 @entity3257 @entity1821
@entity3257 ( @entity3257 ) represent 23%-34% of @entity235 primary @entity242 . @entity1821 account for 2%-6% of @entity3257 but myxoid variants are rarely reported and information on their behaviour is fragmentary. An 8-year-old male crossbreed (case 1), a 12-year-old female French bulldog (case 2), and an 11-year-old crossbreed (case 3) underwent splenectomy after the detection of a splenic nodule. Histology, histochemistry, immunohistochemistry, and @entity1579 ( @entity1579 ) were performed. Bundles of spindle-to-polygonal cells containing occasional cytoplasmic oil-red-O positive vacuoles embedded in an Alcian blue-positive extracellular matrix were observed. Aggregates of round cells were detected in cases 1 and 3. All @entity5 were vimentin positive and actin, @entity38630 , @entity11691 , and S100 negative. The @entity1579 evidenced different maturational stages of adipose cells (lipoblasts, intermediate, and undifferentiated). All the cases developed hepatic @entity3 and were euthanized. Disease free interval was 2 months in cases 1 and 3, and 21 months in case 2. The presence of a neoplastic embolus in case 1 and areas of round cell differentiation in cases 1 and 3 represented the sole prognostic indices.
