Effects of age and dysfunction on XXXX meibomian glands.

@entity1 @entity409 @entity1195 @entity194 @entity936 @entity3066 @entity6864
OBJECTIVE: To identify age-related changes in @entity1 meibomian glands that may be associated with @entity409 ( @entity409 ). METHODS: Excess eyelid tissue from 36 @entity1 (age range, 18-95 years, 19 female, 17 male) who underwent canthoplasty procedures were used. Dermatologic history, age, and presence of @entity409 were recorded. Samples were frozen, sectioned, and stained with specific antibodies against @entity6864 ( @entity6864 ) to identify meibocyte differentiation, Ki67 nuclear antigen to identify cycling cells, and @entity1195 to identify inflammatory cell infiltration. RESULTS: Staining for @entity6864 showed cytoplasmic and nuclear localization in the 2 youngest subjects (ages, 18 and 44 years). Older individuals (>60 years) showed predominantly nuclear staining, with cytoplasmic staining limited to the basal acinar cells in 17 of 31 subjects. The number of Ki67 positively stained basal cells were significantly elevated in the younger compared with older subjects based on linear regression analysis (r(2) = 0.35; P < .001). There was also a significant correlation between MG expression grade and @entity1195 cell infiltration (r = 0.414; P = .05). CONCLUSIONS: These results indicate that aging @entity1 meibomian glands show decreased meibocyte differentiation and cell cycling that is associated with the development of @entity409 . Findings also suggest that altered @entity6864 signaling may lead to acinar @entity194 and development of an age-related hyposecretory @entity409 . CLINICAL RELEVANCE: @entity409 and evaporative @entity936 are common age-related @entity3066 . Understanding the underlying mechanism of @entity409 may lead to the development of novel therapeutic strategies to treat this disease.
