Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult XXXX .

@entity1 @entity281 @entity2268
PURPOSE: To determine the incidence and the risks factors of peripherally inserted central catheter (PICC)-related infectious complications. MATERIALS AND METHODS: Medical charts of every in- @entity1 that underwent a PICC insertion in our hospital between January 2010 and October 2013 were reviewed. All PICC-related @entity281 were recorded and categorized as catheter-related bloodstream @entity281 (CR-BSI), exit-site @entity281 , and septic @entity2268 . RESULTS: Nine hundred and twenty-three PICCs were placed in 644 unique @entity1 , mostly male (68.3%) with a median age of 58 years. 31 (3.4%) PICC-related @entity281 occurred during the study period corresponding to an infection rate of 1.64 per 1000 catheter-days. We observed 27 (87.1%) CR-BSI, corresponding to a rate of 1.43 per 1000 catheter-days, 3 (9.7%) septic @entity2268 , and 1 (3.2%) exit-site infection. Multivariate logistic regression analysis showed a higher PICC-related infection rate with chemotherapy (odds ratio (OR) 7.2-confidence interval (CI) 95% [1.77-29.5]), auto/allograft (OR 5.9-CI 95% [1.2-29.2]), and anti-coagulant therapy (OR 2.2-95% [1.4-12]). CONCLUSION: Chemotherapy, auto/allograft, and anti-coagulant therapy are associated with an increased risk of developing PICC-related @entity281 . CLINICAL ADVANCE: Chemotherapy, auto/allograft, and anti-coagulant therapy are important predictors of PICC-associated @entity281 . A careful assessment of these risk factors may be important for future success in preventing PICC-related @entity281 .
