Cognitive function and anticonvulsant therapy: effect of monotherapy in XXXX .

@entity1 @entity2051 @entity1092 @entity109 @entity302 @entity3174 @entity2049
INTRODUCTION: The effect of antiepileptic drugs (AED) on cognitive function was studied in 87 @entity1 with @entity302 . MATERIAL AND METHODS: Group A: (n = 52) started AED treatment ( @entity2049 , @entity2051 , @entity1092 , @entity109 or @entity3174 ). Group B: (n = 27) had AED monotherapy withdrawn ( @entity2049 or @entity1092 ). Group C: (n = 8) was switched from @entity3174 to @entity2049 monotherapy. The @entity1 were tested before and 4 months after change of the treatment. RESULTS: In group A the test performances were in general unchanged. @entity1 who had their drug treatment withdrawn (group B) and the @entity1 who were switched from @entity3174 to @entity2049 (group C) improved in single tests. The predominant changes in performance seem to be due to practice effect. CONCLUSION: Cognitive functions are only minimally influenced by AEDs after short-term treatment whereas there is a slight improvement after discontinuation of long-term administration of @entity2049 and @entity1092 . A lack of practice effect might be the first indicator of a negative effect of AED on cognitive function.
