Nigrostriatal dopaminergic depletion produces orofacial XXXX .

@entity2847 @entity1931 @entity935 @entity128 @entity158 @entity35 @entity2955 @entity9
BACKGROUND: @entity935 is implicated in different @entity158 . The mechanisms underlying this invalidating @entity158 are not yet understood. Therefore, the present study investigated if unilateral or bilateral lesions of the medial forebrain bundle (MFB) could induce a trigeminal @entity1931 ( @entity1931 ) comparable to that obtained after chronic construction @entity128 (CCI-IoN) in @entity35 . METHODS: Unilateral and bilateral nigrostriatal lesions were obtained by injecting @entity2955 into the MFB, and peripheral lesion was obtained by CCI-IoN. Static allodynia behaviour was tested by a mild non-noxious static von Frey filament stimulus. The analgesic effects of @entity2847 (D2R agonist) were assessed by both intraperitoneal and intracisternal injections. Finally, immunohistochemical study was done to investigate the implication of the protein kinase c isoform gamma (PKCy) and the phosphorylated form of extracellular signal-related kinase 1/2 (pERK1/2) in @entity158 sensitization at segmental level. RESULTS: @entity2955 -lesioned animals developed @entity1931 in the orofacial region as assessed by non-noxious stimuli. Intraperitoneal and intracisternal injections of @entity2847 alleviated this allodynic behaviour. Investigations within the medullary dorsal horn revealed an increase in PKCy expression, a protein implicated in the chronicity of @entity158 , within superficial laminae in @entity2955 -lesioned @entity35 . Also static mechanical stimulations of the orofacial region evoked increased expression of the molecular @entity158 marker pERK1/2 in @entity2955 -lesioned @entity35 . CONCLUSION: Our data show that unilateral and bilateral @entity935 depletion promoted trigeminal @entity1931 comparable to that obtained after CCI-IoN. This allodynia can be alleviated by D2R activation, making D2R agonist a potential analgesic for orofacial @entity9 .
