Self-reported Conflicts of Interest and Trial Sponsorship of Clinical Trials in XXXX Involving Radiotherapy.

@entity9859 @entity1 @entity263
OBJECTIVES: To examine the association between trial sponsorship and conflicts of interest ( @entity9859 ) with clinical trial conclusions for @entity263 trials related to radiotherapy. MATERIALS AND METHODS: The MEDLINE database was searched for all @entity263 clinical trials published between 2004 and 2013 and identified 1396 studies. Two investigators independently identified trials published in the English language of >= 30 @entity1 , and extracted relevant data. Clinical trials were classified according to trial characteristics, sponsorship source and type, @entity9859 , and study conclusion, and analyzed by univariable and multivariable logistic regression. RESULTS: Of 240 eligible trials, 160 (67.5%) evaluated drugs without radiotherapy, 60 (25%) involved radiotherapy, and 18 (7.5%) involved procedures without radiotherapy. Of the 60 radiotherapy trials eligible for analysis, positive sponsorship and potential @entity9859 were present in 58.3% and 20% of trials, respectively. Study conclusions were positive, negative, or neutral in 78.3%, 5%, and 16.7% of trials, respectively. No association was found between positive conclusions and either industry support of potential @entity9859 . Positive conclusions were reported in 86.7% and 83.3% of trials with sponsorship and @entity9859 , respectively, as compared with 75.6% and 77.1% of those without sponsorship (P=0.37) and @entity9859 (P=0.64). Sponsorship was significantly associated with radiotherapy trials combined with drugs (odds ratio 5.5, P=0.01) and higher-risk disease (odds ratio 4.71, P=0.01). CONCLUSIONS: The presence of sponsorship was associated with radiotherapy trials involving drugs or studying @entity263 . However, there were no identified associations between study conclusion and sponsorship type or @entity9859 .
