Effects of Intratumoral Inflammatory Process on XXXX Uptake: Pathologic and Comparative Study with 18F-Fluoro-a-Methyltyrosine PET/CT in @entity957 .

@entity1 @entity32 @entity8984 @entity419 @entity5 @entity535 @entity957
UNASSIGNED: The accurate depiction of both biologic and anatomic profiles of @entity5 has long been a challenge in PET imaging. An @entity32 , which is innate in the carcinogenesis of @entity957 ( @entity957 ), frequently complicates the image analysis because of the limitations of @entity419 and maximum standardized uptake values (SUVmax). New PET parameters, metabolic @entity5 volume (MTV) and total lesion glycolysis (TLG), as well as (18)F-fluoro-a-methyltyrosine ((18)F-FAMT), a malignancy-specific @entity535 -based PET radiotracer, are considered more comprehensive in @entity5 image analysis. Here, we showed the substantial effects of the intratumoral inflammatory process on @entity419 uptake and further study the possibility of MTV and TLG to predict both @entity5 biology (proliferation activity) and anatomy (pathologic @entity5 volume). METHODS: @entity419 and (18)F-FAMT PET images from 25 @entity957 @entity1 were analyzed. SUVmax on the @entity5 site was obtained. PET volume computerized-assisted reporting was used to generate a volume of interest to obtain MTV and TLG for @entity419 and total lesion retention (TLR) for @entity8984 -FAMT. The whole @entity5 dissected from surgery was measured and sectioned for pathologic analysis of @entity5 @entity32 grade and Ki-67 labeling index. RESULTS: The high SUVmax of @entity419 was related to the high @entity32 grade. The SUVmax ratio of @entity419 to @entity8984 -FAMT was higher in inflammatory @entity5 (P < 0.05) whereas the corresponding value in @entity5 with a low @entity32 grade was kept low. All @entity8984 -FAMT parameters were correlated with Ki-67 labeling index (P < 0.01). Pathologic @entity5 volume predicted from MTV of @entity8984 -FAMT was more accurate (R = 0.90, bias = 3.4    6.42 cm(3), 95% confidence interval = 0.77-6.09 cm(3)) than that of @entity419 (R = 0.77, bias = 8.1    11.17 cm(3), 95% confidence interval = 3.45-12.67 cm(3)). CONCLUSION: @entity419 uptake was overestimated by additional uptake related to the intratumoral inflammatory process, whereas (18)F-FAMT simply accumulated in @entity5 according to @entity5 activity as evaluated by Ki-67 labeling index in @entity957 .
