Pressure and frequency dependent linkage between motility and epithelial secretion in XXXX proximal small intestine.

@entity1 @entity294 @entity194 @entity841
BACKGROUND: Motor disturbances are sometimes associated with @entity294 by unknown mechanisms. AIM: To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS: Experiments were performed in 21 healthy volunteers and three @entity1 with @entity194 . METHODS: Duodenal and jejunal motor activities were registered in the fasted state by open tip manometry. Secretion was measured directly by marker perfusion and indirectly by recording transmural @entity841 ( @entity841 ). RESULTS: A significant correlation was found between "low pass filtered" pressure and @entity841 , but no correlation was found between amplitudes of isolated contractions and @entity841 changes. During repeated phasic contractions (phase III of migrating motor complex), @entity841 increased at a rate that was higher in the duodenum than in the jejunum, and higher in @entity1 with @entity194 than in healthy controls. After reaching a peak, @entity841 decreased despite continuing phasic motor activity, provided that there was no concomitant increase in mean pressure. Fluid secretion increased roughly in parallel with @entity841 , except at the very end of the cycle. CONCLUSIONS: To explain these findings, one has to postulate participation of at least two types of receptor: a slowly adapting pressure sensitive receptor and another mechanoreceptor, possibly a mucosal touch receptor, to account for the run down phenomenon. This model predicts that short lasting trains of contractions, so called discrete clusters, will be a particularly potent stimulus for activation of mucosal secretion.
