Prevalence of intimal @entity1457 protein 60 homologues in XXXX and correlation with anti- @entity1457 protein antibody titers.

@entity1 @entity301 @entity1457 @entity5749 @entity1459 @entity453 @entity2939 @entity11217 @entity1851
@entity1457 proteins (HSPs) are among the most highly conserved and immunogenic proteins shared by microbial agents and mammals. @entity1 (h) @entity11217 is upregulated under stress conditions and serves as a target for cross-reactive cytotoxic HSP-serum-antibodies. The present study evaluates the expressions of @entity11217 and its homologue chlamydial (c) @entity11217 in advanced @entity1 @entity301 and correlates intimal tissue-bound HSP expressions with circulating HSP-antibodies. Coronary atherectomy specimens retrieved from 100 primary target lesions of @entity1 with @entity1459 ( @entity1459 ; n  =  40) or @entity5749 ( @entity5749 ; n  =  60) were assessed immunohistochemically for the presence of @entity11217 and cHSP60. In a subgroup (n  =  40), blood samples were tested for anti-Chl. pn.-IgG/IgA-titers and anti- @entity11217 -antibody titers. Coronary plaques revealed immunoreactive @entity11217 in 55% and cHSP60 in 45% of the lesions. Expression of both HSP homologues was significantly (each p  <  0.001) higher in @entity1459 lesions compared with @entity5749 lesions (7.4 vs. 1.2% and 6.0 vs. 1.1%). HSP homologues showed positive correlations both in @entity1459 - and @entity5749 -lesions (r  =  0.41, 0.33; p  <  0.05). cHSP60 showed no association with anti-Chl. pn.-IgG/IgA-titers, whereas expressions of both homologues correlated positive with anti- @entity11217 -Ab titers (r  =  0.42, p  <  0.05; r  =  0.50, p  <  0.01). Intimal amounts of @entity11217 homologues were associated with increased expressions of @entity1851 , @entity2939 . @entity1 and chlamydial @entity11217 colocalize within @entity301 , most prevalent in lesions associated with @entity1459 . Our data demonstrate a significant correlation between the intimal expressions of @entity11217 homologues and serum @entity11217 antibodies, thereby suggesting that humoral immune reactions may play an important role in @entity453 and plaque instability.
