Visceral pleura invasion and pleural lavage XXXX cytology by @entity2 : a prospective appraisal.

@entity1 @entity1143 @entity5 @entity2 @entity1149 @entity3
BACKGROUND: Despite an early-stage diagnosis, @entity2 presenting with @entity3 ( @entity3 ) or malignant pleural lavage cytology (PLC) has a poor prognosis. The purpose of this study was to correlate @entity3 to malignant PLC. METHODS: One hundred forty-three consecutive @entity1 scheduled for surgical lung resection having undergone preresectional pleural lavage cytology were reviewed. There were 121 malignant and 22 nonmalignant lesions. All cases were studied by pathology, histology, previous transthoracic puncture, @entity3 , and presence of pleural lymphatic involvement. RESULTS: PLC was positive (n = 13) or suspected (n = 5) for malignant cells in, respectively, 10.7% and 4.1% of @entity1 with @entity2 . There was no positive PLC in cases of nonmalignant disease. PLC was positive only in pT2 @entity5 and almost always when the @entity5 was exposed on the pleural surface, thus possibly exfoliating within the pleural space (12/17 @entity1 , 70.6%; p < 0.01). Positive PLC was obtained whatever the histology but did not appear related to previous transthoracic puncture or involvement of pleural lymphatics by @entity5 cells. CONCLUSIONS: @entity3 and positive PLC are linked, and the appearance of @entity5 cells within the @entity1143 can be explained by @entity5 desquamation. The role that visceral pleura involvement and parietal pleura reabsorption play in @entity2 is of paramount importance and deserves further research. A better understanding of their relationship could have major implications in the therapeutic management of @entity1149 .
