Disturbances in XXXX secretion and action in adolescents with @entity1278 .

@entity1 @entity851 @entity2301 @entity442 @entity1278 @entity2124 @entity3147 @entity9045
@entity1 in whom @entity1278 develops during adolescence have failure of linear growth associated with low levels of insulin-like growth factor I ( @entity442 ). To investigate the pathophysiology of @entity851 in adolescents with @entity1278 , we measured basal @entity2124 ( @entity2124 ), @entity9045 ( @entity9045 ), @entity442 , and @entity2301 ( @entity2301 ) in three groups of @entity1 : (1) 28 recently hospitalized female adolescents with @entity1278 , (2) 23 of the same @entity1 after partial weight restoration, and (3) 28 healthy control subjects matched for age, sex, and pubertal stage. Fasting @entity2124 levels in group 1 did not differ significantly from those in group 3. In contrast, serum @entity9045 (p < 0.001), @entity442 (p < 0.001), and @entity2301 (p < 0.01) were significantly lower in group 1 than in group 3. Serum @entity9045 and @entity2301 levels were positively correlated with body mass index. Serum @entity9045 levels were low in @entity1 in all five pubertal stages and even in those shown to have adequate @entity2124 secretion. In group 2 (after refeeding) the serum @entity442 concentration increased significantly and @entity9045 and @entity2301 returned to normal. We conclude that @entity1 with @entity1278 have diminished @entity2124 action resulting in decreased secretion of @entity442 . The positive correlation with body mass index and the reversibility with refeeding suggest that these changes are secondary to @entity3147 . Altered @entity2124 function that occurs during the years of active growth can explain the @entity851 seen in @entity1278 .
