Predictive factors for early symptomatic recurrence in XXXX : does angiogenesis have a role to play?

@entity1 @entity816 @entity5 @entity7
We studied predictive factors with respect to angiogenesis and proliferative indices for early symptomatic recurrences in @entity1 with @entity816 ( @entity816 ). One hundred and eighteen @entity1 who underwent surgery for @entity816 were divided into non-recurrent and early symptomatic recurrence groups to analyze clinicoradiological and immunohistopathological (n=33) parameters. @entity1 with @entity5 presented with symptoms for a mean duration of 10.2    9.1 months while those with recurrent @entity5 presented slightly earlier (6.9    4.5 months). @entity5 locations were the cerebellum (38.1%), optic chiasm (27.9%), supratentorial region (19.4%) and brainstem (9.3%). Recurrent @entity5 were mostly located in the cerebellum (44%) and brainstem (33%). Strong contrast enhancement was noted in 70 (59.3%) @entity5 , while 48 (40.7%) showed poor contrast. Resection was complete in 53% of @entity1 while near total excision was achieved for the remaining @entity1 . Cellularity and pleomorphism were similar in both groups. Extensive endothelial proliferation was observed in 18.1% of @entity1 while the remainder showed a focal pattern. Diffuse @entity7 ( @entity7 ) expression was observed in 36.3% of @entity1 while 63.6% showed mild-to-moderate focal expression. Endothelial proliferation and @entity7 expression were more pronounced in @entity1 with @entity5 , but this was not statistically significant. MIB-I labeling indices were similar (1-5%) for both groups. Symptomatic recurrences were common in infratentorial PAs. Radiology, histopathology and proliferative indices did not offer any prognostic information. Angiogenesis markers such as endothelial proliferation and VEFG expression did not predict early symptomatic recurrence. Diffuse @entity7 expression and endothelial proliferation were observed in @entity5 that showed strong contrast enhancement.
