Modification of endotoxin-induced haemodynamic and haematological changes in the @entity95 by XXXX , F(ab')2 fragments and @entity10419 .

@entity1667 @entity1 @entity882 @entity2404 @entity10419 @entity326 @entity4 @entity1457 @entity95 @entity1426 @entity2918 @entity4770 @entity1431 @entity551
The effects of @entity1667 , F(ab')2 fragments of @entity1 gamma globulins and @entity10419 , an inhibitor of complement activation, were tested on endotoxin-induced haemodynamic and haematological changes in the @entity95 . Their effects were compared with complement depletion by cobra venom factor (CVF) pretreatment. The results provide further evidence for the role of complement activation and the concomitant triggering of the @entity1426 cascade in the early phase of shock. The formation of vasoactive @entity2918 ( @entity4770 and @entity2404 ), the arterial @entity551 and the @entity882 were largely dependent on the presence of the intact complement system. F(ab')2 fragments (150 mg kg-1, i.v.) diminished the second fall in blood pressure to some extent but failed to alter any of the other endotoxin-induced changes. @entity1667 (40 mg kg-1, i.v.) given 10 min before endotoxin significantly reduced the activation of complement, the second rise of @entity4770 and the secondary @entity551 , but was without effect on the early thromboxane peak of the haematological features of endotoxin shock. @entity10419 (20 mg kg-1, i.v.) may be of potential interest for treatment of @entity326 , since the drug suppressed the endotoxin-induced activation of complement, the formation of @entity4770 , both @entity551 phases, the @entity882 and the concomitant release of @entity2404 . The role of leukocytes and their @entity1426 metabolites in plasma exudation deserves further investigation, because @entity1431 and @entity4 were not complement-dependent and were not affected by any of the treatments. Our results indicate that drugs, interfering with complement activation and/or prostaglandin biosynthesis, may be @entity1457 , provided that they are administered at an early stage.
