Non-linear significant relationship between use of glycopeptides and isolation of XXXX -resistant Enterococcus species in a university hospital setting.

@entity1 @entity2176 @entity48094 @entity2886 @entity11248 @entity2887 @entity2794
BACKGROUND: Emergence of colonization and infection with @entity2176 -resistant enterococci (VRE) has become a worldwide challenge. To investigate whether the increasing incidence of VRE isolation can be correlated with use of glycopeptides in the hospital setting, we conducted a hospital-wide two-year study in the university hospital of Vienna. METHODS: Within the period from January 2011 through December 2012 all @entity1 with isolation of invasive or non-invasive VRE were retrospectively included. Specialty-specific data concerning the consumption of @entity2176 and @entity11248 , @entity2887 and third generation @entity2886 in @entity2794 ( @entity2794 ) from June 2010 through May 2012 were extracted from the hospital pharmacy computer system. To assess the relationship between the usage of those antibiotics and the incidence of VRE (VRE-rate per 10 000 @entity1 ) a Poisson regression was performed. FINDINGS: In the study period 266 @entity1 were colonized or infected with VRE. Specialty-specific VRE isolation was as follows: general surgical units (44 @entity1 ), bone marrow transplant unit (35 @entity1 ), general medical units (33 @entity1 ), cardiothoracic surgery (27 @entity1 ), nephrology (26 @entity1 ), haematooncology (22 @entity1 ), gastroenterology (17 @entity1 ), urology (17 @entity1 ), and the infectious diseases unit (11 @entity1 ). Hospital-wide consumption of glycopeptides was higher for @entity11248 than for @entity2176 (26 242 versus 8677 @entity2794 ). Specialty-specific VRE incidence significantly increased with the use of @entity48094 , @entity2887 or third generation @entity2886 (p   <   0.001). The results of the Poisson regression for @entity2176 (p   =   0.0018) and @entity11248 (p   <   0.0001) separately were both highly significant. Spearman's correlation coefficient indicated a strong correlation between the two variables (rho   =   0.8). CONCLUSION: Overall usage of glycopeptides, @entity2887 or third generation @entity2886 contributed to the emergence of VRE in the hospital setting.
