Exercise-induced left ventricular dysfunction in alcoholic and non-alcoholic XXXX .

@entity1 @entity64 @entity82 @entity167 @entity337 @entity4148 @entity299
BACKGROUND/AIMS: Autonomic and @entity299 have been reported in @entity1 with @entity82 . We studied left ventricular and autonomic function in 20 @entity1 with both alcoholic and non-alcoholic @entity82 . METHODS: Autonomic function was assessed by a standard battery of cardiovascular reflex tests. Supine exercise radionuclide ventriculography was used to assess the cardiac response to exercise. RESULTS: Exercise capacity was reduced in all @entity1 in association with marked chronotropic @entity337 (peak heart rates 120.5 +/- 6 bpm). Unlike normal subjects there was no increase in left ventricular ejection fraction on exercise. @entity64 volume increased by 23 +/- 6%, mediated by an increase in end-diastolic.volume of > 20%. Cardiac output was subnormal at maximal exercise, increasing by only 96 +/- 14% and 97 +/- 11% in alcoholic and non-alcoholic groups respectively. The majority (83%) of our @entity1 had @entity4148 . CONCLUSIONS: @entity1 with @entity82 of @entity167 and non- @entity167 related aetiologies have significantly impaired cardiovascular responses to exercise, which are similar to those of a denervated heart. This may have important clinical implications for the ability of these @entity1 to withstand cardiovascular stress.
