MicroRNA-498 is downregulated in @entity1149 and correlates with XXXX progression.

@entity1 @entity5 @entity1149 @entity41156 @entity2
OBJECTIVE: @entity1149 ( @entity1149 ) is the most common type of @entity1 @entity2 , with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated with @entity1149 . In this study, we sought to determine the expression, the clinical value and its role in @entity1149 progression. METHODS: Clinical @entity1149 tissues and common cell lines were collected. Real-time PCR was performed to quantify the @entity41156 expression. In addition, the association of @entity41156 expression with clinical pathological factors and prognosis was statistically analyzed. Furthermore, cell proliferation was measured after @entity41156 was overexpressed transiently in cells. RESULTS: We found that @entity41156 was significantly decreased in @entity1149 as well as cell lines, when compared with their separated controls. Decreased @entity41156 expression was associated with sex, @entity5 type and @entity5 size. Functionally, ectopic expression of @entity41156 in A549 and H661 cells inhibited cell proliferation. CONCLUSION: Our data indicated that @entity41156 is downregulated and correlated with @entity5 progression, which might be a putitive therapeutic target in @entity1149 treatment.
