Long-term effect of a single dose of @entity599 mustard on nerve conduction velocity and electromyography pattern in XXXX hindlimb.

@entity1 @entity4968 @entity2901 @entity35 @entity599 @entity5723 @entity528
OBJECTIVE: Biological effects of @entity599 mustard (SM) on various systems have been investigated in both @entity1 and animals. However, few studies are available on the effect of SM on the peripheral nervous system. In the present study, long-term effects of a single dose of SM on nerve conduction velocity and electromyography (EMG) pattern is evaluated in hindlimb of adult male @entity35 . METHODS: SM @entity4968 was induced by two means: subcutaneous injection of 1 and 3.5 mg/kg SM in two experimental groups (1 and 2) and cutaneous application of 8 and 13 mg/kg SM in groups 3 and 4. Sham and control groups received SM vehicle, @entity5723 , and nothing, respectively. Electrophysiological assessments were performed after 26 weeks as follows: sciatic nerve conduction study that included measuring, amplitude, duration, and latency of M-wave, F-wave latency, and EMG study in resting and minimal contraction states. RESULTS: Results indicate that sciatic nerve conduction velocity did not significantly change in any experimental groups. However, resting EMG records showed some abnormalities very similar to positive sharp waves and @entity2901 reported in @entity1 . These abnormalities were observed in 6 of 36 intoxicated @entity35 . CONCLUSIONS: Although the present data are in favor of @entity528 , to rule out the possibility of other types of @entity528 , additional thorough studies at ultrastructural level are suggested.
