Analysis of results of radiation therapy for XXXX of the cervix.

@entity1 @entity957 @entity5
From April 1969 through December 1980, 251 @entity1 with invasive, @entity957 of the cervix received radical radiation therapy consisting of a combination of external beam and intracavitary therapy designed to deliver 7000 to 8000 rad to Point A and 6000 to 6500 rad to the pelvic lymph nodes. The disease-free survival at 2, 5, and 10 years for @entity1 with @entity5 was 90%, 76%, and 76%, respectively, whereas for @entity1 with Stage IIB disease it was 77%, 62%, and 59%, respectively. The survival for the entire group at 2, 5, and 10 years was 80%, 65%, and 62%, respectively. Sixty-eight @entity1 had a recurrence within the irradiated volume, for a locoregional recurrence rate of 27% (68/251). In 49 @entity1 complications developed for an overall complication rate of 19.5% (49/251). An analysis of the complications and their degree of severity revealed a correlation with the dose of intracavitary plus external beam therapy given to Point A and to the rectum. The mean dose to Point A for @entity1 with and without complications were 7877 rad (standard error [SE] +/- 95) and 7593 rad (SE +/- 67), respectively. The mean rectal dose for @entity1 with and without intestinal complications were 6767 rad (SE +/- 157) and 6426 rad (SE +/- 78), respectively. The dose difference between @entity1 with and without complications was statistically significant for Point A (P = to 0.0163) but not for the rectal dose (P = to 0.0887). There was no correlation between the bladder dose and urinary complications. Other treatment methods as well as @entity1 and @entity5 parameters, are being currently analyzed to identify which factors, singly or in combination, may contribute to the development of treatment failures or complications.
