Combination therapy for XXXX .

@entity1 @entity8974 @entity3101 @entity6 @entity37129 @entity6313 @entity20517 @entity2059
Combination therapy is one way of improving the cure rate of @entity6313 . The LION Study examined the efficacies of @entity8974 and @entity2059 . The Icelandic cohort of the study reported that after 5 years only 46% of the @entity8974 -treated @entity1 and 13% of the @entity2059 -treated @entity1 were still disease-free, suggesting that relapses and reinfections were common in the long term treatment of @entity6313 with monotherapy. Combination therapy is a well-established principle in mycology; the current strategy involves the combination of oral and topical antifungal treatments. A number of specific drug combinations have proved to be useful in the treatment of @entity6313 : @entity37129 and @entity3101 , @entity20517 and @entity3101 , @entity20517 and @entity8974 , and @entity20517 and @entity2059 . However, comparison of the combination trials can be difficult because of the short duration of some of the studies and variation in global cure rates. Although it is necessary to consider these factors it is clear that combination therapy offers advantages when compared with monotherapy. Combination therapy can be administered sequentially or in parallel. Parallel therapy is recommended for @entity1 who are likely to fail therapy (e.g. @entity1 with @entity6 ), whereas sequential therapy is recommended for @entity1 who show a poor response to initial treatment.
