Characteristics of XXXX Referred to a Pediatric @entity166 Clinic With Unexplained Fever.

@entity1 @entity3298 @entity7809 @entity221 @entity7551 @entity281 @entity311 @entity166 @entity1682
BACKGROUND: Older case series established diagnostic considerations for @entity1 meeting a priori definitions of @entity221 of unknown origin (FUO). No recent study has examined the final diagnoses of @entity1 referred for unexplained @entity221 . METHODS: This study was conducted with a retrospective chart review of @entity1 referred to a pediatric @entity166 clinic from 2008 to 2012 for unexplained @entity221 . RESULTS: Sixty-nine of 221 @entity1 were referred for "prolonged" unexplained @entity221 . Ten of these were not actually having @entity221 , and 11 had diagnoses that were readily apparent at the initial visit. The remaining 48 were classified as having FUO. The median duration of reported @entity221 for these @entity1 was 30 days; 15 had a diagnosis made, 5 of which were serious. None of the serious FUO diagnoses were @entity281 . Of 152 @entity1 with "recurrent" unexplained @entity221 , 92 had an "intermittent" @entity221 pattern, and most of these had sequential, self-limited viral illnesses or no definitive diagnosis made. Twenty of the 60 @entity1 with a "periodic" @entity221 pattern were diagnosed with periodic @entity221 , @entity7809 , @entity7551 , and @entity3298 . Overall, 166 @entity1 either were not having @entity221 , had self-limited illnesses, or ultimately had no cause of @entity221 discovered. Only 12 had a serious illness, 2 of which were @entity281 ( @entity311 and @entity1682 ). CONCLUSIONS: Most @entity1 referred with unexplained @entity221 had either self-limited illnesses or no specific diagnosis established. Serious diagnoses were unusual, suggesting that these diagnoses rarely present with unexplained @entity221 alone, or that, when they do, the diagnoses are made by primary care providers or other subspecialists.
