Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade XXXX : an image-guided biopsy study.

@entity5 @entity1 @entity11 @entity1758
BACKGROUND AND PURPOSE: As newer MR imaging techniques are used to assist with @entity5 grading, biopsy planning, and therapeutic response assessment, there is a need to relate the imaging characteristics to underlying pathologic processes. The aim of this study was to see how rCBV, a known marker of @entity5 vascularity, relates to cellular packing attenuation and cellular proliferation. MATERIALS AND METHODS: Nine @entity1 with histologically proved high-grade @entity11 and 1 with a supratentorial PNET requiring an image-guided biopsy were recruited. @entity1 underwent a DSC study. The rCBV at the intended biopsy sites was determined by using a histogram measure to derive the mean, maximum, and 75th centile and 90th centile values. This measure was correlated with histologic markers of the @entity1758 labeling index (as a marker of @entity11 cell proliferation) and the total number of neoplastic cells in a high-power field (cellular packing attenuation). RESULTS: There was a good correlation between rCBV and @entity1758 by using all the measures of rCBV. The mean rCBV provided the best results (r = 0.66, P < .001). The only correlation with cellular packing attenuation was with the 90% centile (rCBV(90%), r = 0.36, P = .03). The increase in rCBV could be seen over 1 cm from the edge of enhancement in 4/10 cases, and at 2 cm in 1/10. CONCLUSIONS: rCBV correlated with cellular proliferation in high-grade @entity11 but not with cellular packing attenuation. The increase in rCBV extended beyond the contrast-enhancing region in 50% of our @entity1 .
