Systemic acute phase proteins response in XXXX experimentally infected with Eimeria zuernii.

@entity32 @entity294 @entity4306 @entity281 @entity1017 @entity7019 @entity291 @entity12314
UNASSIGNED: Acute phase proteins (APPs) have been demonstrated to be useful in evaluating general health stress and diseases in cattle. @entity7019 ( @entity7019 ) and @entity12314 (Hp) are APPs that are produced during @entity32 , and likely play a role in host immunological defence against @entity281 and the associated intestinal tissue damage. We investigated the involvement of @entity7019 and @entity4306 in an experimental study, including three groups of @entity291 : a control group (group 0, n=11), and two groups infected with either 150,000 or 250,000 Eimeria zuernii oocysts (group 1 (n=11) and group 2 (n=12), respectively). The @entity291 were monitored for 28 days and data was collected on oocyst excretion, faecal score, animal weight, and @entity7019 and Hp serum concentrations. Generalized linear mixed models showed that the clinical symptoms, indicated by an increase in the number of oocysts in the faeces and severe @entity294 , manifested at patency for group 1 and 2. Serum Hp and @entity7019 levels also increased during this period. Hp appeared to be a more sensitive marker than @entity7019 , and differences between groups 1 and 2 were observed only for Hp. Linear regression models showed a negative association between @entity1017 and Hp concentrations, calculated as the area under the curve (AUC) during the overall experimental period and the patency period. A similar result was seen for @entity7019 only during the patency period. This result supports the assumption that reduced @entity1017 due to E. zuernii @entity281 is an immunologically driven process that involves an increase in APPs. A random intercept regression model of oocyst shedding groups showed that @entity291 shedding 1-500 oocysts had reduced concentrations of Hp, indicating that a different immunological reaction occurs during mild shedding of E. zuernii oocysts than during more intensive shedding. A similar model was used to examine associations between faecal scores and Hp concentrations for each group. Group 2 @entity291 with haemorrhagic @entity294 displayed higher Hp levels than @entity291 in that group with lower faecal scores, which may be in response to an increased demand for Hp in the repair process as a result of haemolysis. APPs seem to play an important role in determining the course of E. zuernii @entity281 in @entity291 , which may enhance our understanding of the immunological reaction and development of this disease.
