Polarized in vivo expression of XXXX and @entity4155 between acute and chronic @entity272 .

@entity1 @entity32 @entity483 @entity82 @entity4382 @entity565 @entity1373 @entity4155 @entity2533 @entity56 @entity272 @entity1413
BACKGROUND: In @entity483 ( @entity483 ) there is evidence of tissue @entity82 involving a number of structural changes, including papillary dermal @entity82 and @entity1373 . These changes are suggested to be the result of @entity32 . Several remodeling-associated cytokines, including @entity2533 , @entity4382 , and @entity4155 , have been shown to be increased in @entity56 , including @entity565 . OBJECTIVE: We investigated @entity2533 , @entity4382 , and @entity4155 expression in skin biopsy specimens recovered from acute and chronic @entity272 from @entity1 with @entity483 , as well as from uninvolved skin of @entity1 with @entity483 and skin from healthy volunteers. We also examined the correlation between the expression of these cytokines and the extent of total, type I, and type III collagen deposition. METHODS: We evaluated the expression of @entity2533 , @entity4382 , and @entity4155 by means of immunohistochemistry. Collagen deposition was assessed by means of immunohistochemistry and van Gieson staining. RESULTS: @entity2533 expression was markedly enhanced in both acute and particularly chronic lesions (P <.001). Although @entity4382 expression was significantly increased only in chronic lesions (P <.0001), @entity4155 was preferentially associated with acute lesions (P <.005). Although @entity1413 was not significantly different among the groups, type I collagen deposition was significantly increased in chronic @entity483 (P <.0005). There was a significant correlation between @entity4382 and type I collagen deposition, as well as the number of eosinophils in skin specimens from @entity1 with @entity483 (r (2) = 0.527, and r (2) = 0.622, respectively; P <.0001). CONCLUSION: These results suggest that @entity2533 , @entity4382 , and @entity4155 are involved in the remodeling of @entity272 in @entity1 with @entity483 . However, @entity4382 and @entity4155 are preferentially expressed at different stages of the disease. Type I collagen appeared to be the major subtype involved in this repair process.
