Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and XXXX detected by fluorescence in situ hybridization.

@entity7465 @entity5 @entity517 @entity4910 @entity2184 @entity320 @entity1722
To assess the differences between @entity320 of different location and different etiology, 372 @entity320 were brought in a tissue microarray format. The collection included 23 acral and 118 @entity320 , @entity320 , 100 @entity2184 , and 122 @entity320 metastases. Fluorescence in situ hybridization (FISH) was used to assess copy number changes of the @entity4910 ( @entity4910 ), @entity7465 , @entity517 ( @entity517 ), and @entity1722 genes. FISH analysis revealed distinct differences between @entity320 from different locations. @entity4910 amplifications were detected in @entity320 from sites with chronic sun exposure (6 of 32 cases), acral @entity320 (4 of 17 cases), and @entity320 (one of ten cases) but not in @entity2184 . High-level @entity7465 amplifications were exclusively present in acral @entity320 (2 of 19 cases). @entity517 copy number gains were detected in 32 of 71 @entity2184 , @entity320 , and 6 of 67 @entity320 from sites with intermittent sun exposure but not in acral @entity320 nor @entity320 from sites with chronic sun exposure. Alterations of the @entity517 gene were associated with advanced @entity5 stage. There were no high-level @entity1722 amplifications. Site-specific genetic and epigenetic features may impact the response of @entity320 to various anti- @entity5 drugs and should be considered in future studies on the molecular pathogenesis of @entity320 .
