XXXX and its influence on lymph node status.

@entity0 @entity1722 @entity5 @entity470 @entity4205 @entity3 @entity6881 @entity1491
BACKGROUND: Basal-like @entity0 often are regarded for circumscribed solitary lesions having unfavorable prognosis. On the other hand, a considerable proportion of @entity0 is multifocal and has increased metastatic potential. In this study, we analyzed the subgross distribution of the lesions in a @entity1491 , compared it with that in nonbasal-like @entity5 and studied the frequency of vascular invasion and lymph node @entity3 in relation to focality of the lesions. METHODS: A total of 511 consecutive cases documented in large-format histologic sections were studied. Tumors expressing at least one of the basal (myoepithelial) markers ( @entity4205 , @entity6881 , @entity470 ) in at least one of the invasive @entity5 foci were categorized as basal-like @entity5 . Triple-negative (ER/PR/ @entity1722 -negative) basal-like carcinomas also were analyzed. The distribution of lesions and the frequency of vascular invasion and lymph node @entity3 were analyzed. The study was approved by the Regional Ethical Committee Uppsala-  rebro. RESULTS: In 44% of cases, the invasive component was multifocal or diffuse. Combining the in situ and invasive @entity5 components resulted in 61% of cases with multifocal/diffuse distribution. The only statistically significant difference observed was that basal-like @entity5 lacked in situ components more often (21% vs. 9%; P  =  0.0075). No significant differences could be demonstrated regarding vascular invasion and lymph node status. Lymph node @entity3 appeared significantly more frequently in multifocal cases in both @entity5 categories. CONCLUSIONS: Basal-like @entity0 are as frequently multifocal as their non-basal-like counterparts; multifocality is associated with increased risk for vascular invasion and lymph node @entity3 in both @entity5 categories.
