The XXXX MOX gene presents two alternative transcription start points differentially utilized and sensitive to respiratory activity.

@entity72525 @entity1042 @entity48328 @entity19168 @entity653 @entity505 @entity413
The peroxisomal @entity1042 metabolism of @entity19168 depends on a group of genes that are coordinately regulated. @entity1042 oxidase (Mox) plays a key role in this pathway and its synthesis has been shown to be regulated at the transcriptional level. MOX expression is strongly repressed on @entity413 and activated on @entity653 or @entity1042 . In this study we have identified two MOX transcripts that are differentially expressed along MOX derepression. The first one, named @entity48328 (for longer MOX), starts at position -425, is only weakly and transiently transcribed and is not translated into the Mox protein. The other is the true MOX mRNA, which initiates around position -25. Using a strain bearing multiple copies of MOX( @entity72525 ) and a reporter gene fused to the MOX promoter, regulation of the two transcripts was investigated. Initiation of the true MOX correlates with repression of @entity48328 and conditions that are repressive for MOX transcription, such as the inhibition of mitochondrial activity, lead to higher levels of @entity48328 expression. This effect was first observed in a mox mutant (Q1N-M8) unable to grow on nonfermentable @entity505 sources. No function was detected for @entity48328 , but its regulation follows a pattern similar to that of catalase, which is essential for @entity1042 metabolism. This suggests that, @entity48328 , although precisely regulated, seems to be a remnant of the evolution of the @entity1042 metabolism network.
