Acute @entity299 events  <=30  days after laboratory-confirmed XXXX among U.S. veterans, 2010-2012.

@entity1 @entity778 @entity712 @entity281 @entity683 @entity955 @entity299 @entity1011 @entity583 @entity2401 @entity65
BACKGROUND: @entity299 is a known potential complication of @entity281 . Because U.S. veterans cared for at the U.S. Department of Veterans Affairs are older and have more @entity65 ( @entity65 ) risk factors than the general U.S. population, veterans are at risk for @entity299 of @entity281 . We investigated biomarkers of @entity299 characteristics and associated @entity299 among veterans who received cardiac biomarker testing  <=30  days after laboratory-confirmed @entity778 . METHODS: Laboratory-confirmed @entity683 cases among veterans cared for at U.S. Department of Veterans Affairs' facilities for October 2010-December 2012 were identified using electronic medical records (EMRs). Influenza confirmation was based on respiratory specimen viral culture or antigen or nucleic acid detection. Acute @entity299 (ACI) was defined as an elevated cardiac biomarker (troponin I or @entity1011 kinase isoenzyme MB) >99  % of the upper reference limit occurring  <=30  days after @entity683 specimen collection. EMRs were reviewed for demographics, @entity65 history and risk factors, and ACI-associated @entity299 . RESULTS: Among 38,197 @entity1 with @entity683 testing results, 4,469 (12  %) had a positive result; 600 of those @entity1 had cardiac biomarker testing performed  <=30  days after @entity683 testing, and 143 (24  %) had one or more elevated cardiac biomarkers. Among these 143, median age was 73  years (range 44-98 years), and 98 (69  %) were non-Hispanic white. All @entity1 had one or more @entity65 risk factors, and 98 (69  %) had a history of @entity65 . Eighty-six percent of ACI-associated events occurred within 3  days of @entity683 specimen collection date. Seventy @entity1 (49  %) had documented or probable acute @entity583 , 8 (6  %) acute @entity712 , 6 (4  %) @entity2401 , and 4 (3  %) @entity955 . Eleven (8  %) had non-cardiac explanations for elevated cardiac biomarkers, and 44 (31  %) had no documented explanation. Sixty-eight (48  %) @entity1 had received @entity683 vaccination during the related @entity683 season. CONCLUSION: Among veterans with laboratory-confirmed @entity281 and cardiac biomarker testing  <=30  days after @entity683 testing, approximately 25  % had evidence of ACI, the majority within 3  days. Approximately half were @entity583 . Our findings emphasize the importance of considering ACI associated with @entity281 among @entity1 at high risk, including this older population with prevalent @entity65 risk factors.
