Presence of prolonged dispersion of qt intervals in late survivors of childhood XXXX therapy.

@entity1 @entity1164 @entity712 @entity944 @entity5 @entity4349 @entity299 @entity1162 @entity943 @entity204
To determine the incidence of abnormal dispersion of QT intervals on an ECG the authors measured these intervals in long-term survivors after @entity4349 treatment for childhood @entity5 and compared the incidence to the traditional markers, @entity1162 . @entity1162 (QTd) and @entity1162 (QTcd) have been associated with serious @entity943 and @entity944 in many forms of @entity299 . The above intervals and shortening fraction (SF) on echocardiogram were determined in 64 late survivors who were 4-22 years post @entity4349 therapy. They were divided into 2 groups: group I, 39 @entity1 with normal function with SF >or= 29%, and group II, 15 @entity1 with SF < 29%. An additional 10 @entity1 had died and had SF < 29% at the time of @entity204 . They were divided into 2 groups: group III, 5 @entity1 who died with @entity712 after a mean of 12 years from of therapy, and group IV, 5 @entity1 who had a @entity1164 after a mean of 9 years from end of therapy. In group I @entity1 , the incidence of @entity1162 was < 6%, whereas that of QTd and QTcd was > 38%. In group II @entity1 , the presence of @entity1162 was < 16%, whereas that of QTd and QTcd was > 40%. The QTc (p =.01), QTd (p =.02), and QTcd (p =.01) were significantly higher and SF (<.01) significantly lower in group IV compared to those alive (group I and II @entity1 ) with no significant difference in age, number of years of follow-up, precordial radiation dose, or @entity4349 dose between the two. The combination of QTcd > 110 ms and diminished SF < 29% was found to be associated with @entity944 . In summary, the long-term survivors of @entity4349 therapy had a high incidence (>38%) of abnormally prolonged QT dispersion intervals, QTd and QTcd, even in those with normal QT and QTc on an ECG and normal shortening fraction on an echocardiogram.
