Hypoglycemic effects of Welsh onion in an animal model of XXXX .

@entity6 @entity19 @entity3839 @entity35 @entity11669 @entity375 @entity4854 @entity413
Tight control of blood @entity413 is the most important strategy for the treatment of @entity6 . Here, we investigated the beneficial effects of Welsh onion on fasting and postprandial @entity4854 . Inhibitory activities of hot water extracts from the green stalk and white bulb, which are the edible portions of the Welsh onion, and the fibrous root extract against @entity375 a-glucosidase were measured in vitro. To study the effects of Welsh onion on postprandial @entity4854 , a starch solution (1 g/kg) with and without Welsh onion fibrous root extract (500 mg/kg) or @entity11669 (50 mg/kg) was administered to @entity3839 -induced @entity6 @entity35 after an overnight fast. Postprandial plasma @entity413 levels were measured and incremental areas under the response curve were calculated. To study the hypoglycemic effects of chronic feeding of Welsh onion, five-week-old db/db @entity19 were fed an AIN-93G diet or a diet containing either Welsh onion fibrous root extract at 0.5% or @entity11669 at 0.05% for 7 weeks after 1 week of adaptation. Fasting plasma @entity413 and blood glycated hemoglobin were measured. Compared to the extract from the edible portions of Welsh onion, the fibrous root extract showed stronger inhibition against @entity375 a-glucosidase, with an IC(50) of 239   g/mL. Oral administration of Welsh onion fibrous root extract (500 mg/kg) and @entity11669 (50 mg/kg) significantly decreased incremental plasma @entity413 levels 30-120 min after oral ingestion of starch as well as the area under the postprandial @entity413 response curve, compared to the control group (P < 0.01). The plasma @entity413 and blood glycated hemoglobin levels of the Welsh onion group were significantly lower than those of the control group (P < 0.01), and were not significantly different from those fed @entity11669 . Thus, we conclude that the fibrous root of Welsh onion is effective in controlling @entity4854 in animal models of @entity6 .
