Clinicopathologic Effect of XXXX Mutation in @entity11511 .

@entity1 @entity71593 @entity5538 @entity11511 @entity15786
BACKGROUND: The present study aimed to determine the frequencies and clinicopathologic effect of a @entity15786 [DNA ( @entity5538 -5)-methyltransferase 3A] mutation in @entity1 with @entity11511 ( @entity11511 ). @entity1 AND METHODS: A total of 64 @entity1 with @entity11511 who had been admitted to Mansoura University Oncology Center were included in the present study. For all @entity1 , DNA extraction and amplification with sequencing analysis using the 310 ABI genetic analyzer for detection of a mutation ( @entity71593 ). RESULTS: The @entity15786 mutation ( @entity71593 ) was found in 12 of the 64 @entity1 (18.8%). The @entity15786 mutation was frequently detected in the older age group and was associated with high leukocytic counts, a high bone marrow blast cell percentage, and the frequent presence of extramedullary disease. However, it was not associated with the hemoglobin level, red blood cell count, or platelet count. The @entity1 with mutant @entity11511 had a low tendency to achieve remission after induction. These @entity1 had significantly shorter overall survival and shorter disease-free survival compared with those with wild-type @entity11511 (P  = .037 and P  = .006, respectively). CONCLUSION: @entity15786 is frequently mutated in @entity11511 and is associated with distinct clinicopathologic entities and a poor prognosis. These findings could help in risk stratification and treatment decisions for @entity1 with @entity11511 .
