Pulmonary manifestations of XXXX .

@entity1 @entity2926 @entity1458 @entity358 @entity1576 @entity1696 @entity382 @entity580
BACKGROUND: Pulmonary manifestations in @entity2926 are considered a major complication and are related to a poor prognosis. We present a large series of @entity1 with @entity358 using a practical approach based on the presence of @entity1576 ( @entity1576 ). METHODS: A retrospective study of @entity1 with confirmed @entity2926 . RESULTS: One hundred and sixty-nine @entity1 with a laboratory-confirmed diagnosis of @entity2926 were investigated. One hundred and thirty-four @entity1 (36.7  14 years of age) had @entity358 . Severe @entity358 was defined by evidence of @entity1576 . Univariate analysis found the following factors related to severe @entity358 : dyspnoea (OR=10.14, p<0.0001), pulmonary crepitations (OR=4.8, p<0.0004), abnormal chest X-ray (OR=9.88, p<0.007) with alveolar shadowing (OR=8.12, p<0.0001), @entity1458 / @entity1696 (OR=5.48, p<0.0001), @entity382 (OR=7.11, p< 0.0001), shock (OR=8.38, p< 0.0001), ICU admission (OR=60.08, p< 0.0001), dialysis (OR=4.87, p< 0.001), mechanical ventilation (OR=216, p< 0.0001) and development of @entity580 (OR=21.5, p< 0.0001). The mortality rate was significantly different between severe (40%) and non-severe (5.3%) pulmonary forms (OR=11.87, p< 0.0001). Multivariate analysis found two independent factors related to severe @entity358 : dyspnoea (OR=10.18, p< 0.0001) and @entity1458 / @entity1696 (OR=4.87, p< 0.0009). We performed a multivariate analysis to assess independent factors related to mortality and found: mechanical ventilation requirement (OR=27.85, p< 0.0001) and AST greater than 150 IU/L (OR=4.57, p< 0.02). Haemoptysis was associated with survival (OR=0.2, p< 0.02). CONCLUSIONS: Severe @entity358 in @entity2926 is associated with extensive disease involving other organs. The association of multiple factors is associated with severe forms of the disease and a high mortality rate.
