Risk factors for XXXX , Dunnigan variety.

@entity1 @entity4223 @entity6 @entity1674 @entity1243 @entity18417 @entity74
OBJECTIVES: @entity18417 ( @entity18417 ), is an @entity74 due to missense mutations in the @entity4223 ( @entity4223 ) gene encoding nuclear lamina proteins. It is characterized by loss of subcutaneous fat from the extremities and trunk and accumulation of fat in the head and neck region beginning at puberty. @entity1 with @entity18417 are predisposed to metabolic complications of insulin resistance such as @entity6 . We sought to identify risk factors for @entity6 in @entity1 with @entity18417 . RESEARCH DESIGN AND METHODS: A cross-sectional study comparing clinical, biochemical, and anthropometric variables and @entity4223 genotypes in @entity18417 @entity1 with and without @entity6 . RESULTS: We studied 52 @entity1 and 24 @entity1 with @entity18417 from 18 different families. Twenty-eight @entity1 (54%) but only four @entity1 (17%) had @entity6 (P < 0.001); therefore further comparisons were mostly limited to @entity1 . Compared with @entity1 without @entity6 , those with @entity6 had higher BMI (median values 23 vs. 24 kg/m(2), respectively; P = 0.03), increased chin skinfold thickness (10 vs. 20 mm; P = 0.001), lower rates of nulliparity (60% vs. 28%; P = 0.04), and higher levels of fasting serum @entity1674 (2.4 vs. 3.5 mmol/l; P < 0.001) but similar serum @entity1243 levels (3.4 vs. 3.6 ng/ml; P = 0.9). The prevalence of @entity6 was not related to age, menopausal status, family history of type 2 @entity6 in unaffected relatives, or @entity4223 genotype. CONCLUSIONS: We conclude that increased adiposity as reflected by excess subcutaneous fat accumulation in the chin region and parity may predispose @entity1 with @entity18417 to develop @entity6 .
