A Comparison of Structural Brain Imaging Findings in Autism Spectrum Disorder and XXXX .

@entity71 @entity4987 @entity2438 @entity245 @entity3057
UNASSIGNED: @entity2438 and @entity71 are regarded as distinct disorders in the current @entity4987 . However, recent research and the RDoC initiative are recognizing considerable overlap in the clinical presentation of @entity2438 , @entity71 , and other @entity245 . In spite of numerous neuroimaging findings in @entity2438 and @entity71 , the extent to which either of the above views are supported remains equivocal. Here we compare structural MRI and DTI literature in @entity2438 and @entity71 . Our main findings reveal both distinct and shared neural features. Distinct expressions were in total brain volume ( @entity2438 : increased volume, @entity71 : decreased volume), amygdala ( @entity2438 : overgrowth, @entity71 : normal), and internal capsule ( @entity2438 : unclear, @entity71 : reduced FA in DTI). Considerable overlap was noted in the corpus callosum and cerebellum (lower volume in structural MRI and decreased FA in DTI), and superior @entity3057 (reduced FA in DTI). In addition, we identify brain regions which have not been studied in depth and require more research. We discuss relationships between brain features and symptomatology. We conclude by addressing limitations of current neuroimaging research and offer approaches that account for clinical heterogeneity to better distinguish brain-behavior relationships.
