Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino XXXX .

@entity308 @entity3175 @entity19 @entity1042 @entity1324 @entity1372 @entity3636 @entity149 @entity148
BACKGROUND: Kaempferia galanga is an important medicinal plant and has been traditionally used to help restlessness, stress, @entity148 , @entity308 etc. in tropics and subtropics of Asia including Bangladesh, India, China, Japan and Indochina. Literature survey revealed that there are very less reports on neuropharmacological activity of this plant. Therefore, the present study investigated the sedative activity of different extracts of rhizome and leaf of Kaempferia galanga. METHODS: The sedative activity was evaluated by using thiopental @entity1372 induced sleeping time, hole cross and open field tests in Swiss albino @entity19 at the doses of 100 and 200  mg/kg body weight per oral (p.o). The @entity1324 extract of rhizome (ACR), as well as petroleum ether fraction (PEF), @entity3636 fraction (CHF), @entity1042 fraction (MEF) and @entity1324 extract of leaf (ACL) were examined for sedative activity. RESULTS: In the sedative activity study, all the extracts exhibited significant (p   <   0.05 and p   <   0.001) reduction of onset and duration of thiopental @entity1372 induced sleeping time, reduction of locomotor and exploratory activities in the hole cross and open field tests. In thiopental @entity1372 induced sleeping time test, the @entity3636 extract of rhizome (200  mg/kg) showed maximum 358.55  % effect in duration of loss of righting reflex, whereas the standard drug @entity3175 (2  mg/kg) produced 231.42  % effect. In hole cross and open field tests, maximum 95.09  % and 95.58  % suppression of locomotor activity were observed with the acetonic leaf extract (200  mg/kg) whereas suppression of locomotor activity of the standard drug @entity3175 were 71.70  % and 70.58  % respectively. CONCLUSION: The present study indicates that the @entity1324 extracts of rhizome and leaf of Kaempferia galanga including fractions @entity149 (CNS) depressant properties which supports its use in traditional medicine. So, the plant may be further investigated to find out for its pharmacological active natural products.
