Factor XIII and XXXX antibodies in @entity29 .

@entity1 @entity66 @entity548 @entity31 @entity344 @entity29 @entity465 @entity8265 @entity30
@entity8265 ( @entity8265 ) has been identified as an autoantigen in @entity66 ( @entity66 ). There is a marked homology between different forms of transglutaminase, such as @entity8265 and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 @entity66 @entity1 , 20 @entity465 ( @entity465 )-negative controls and a group with @entity29 (34 with @entity30 and 23 with @entity31 ). IgA-antibodies against @entity8265 correlated with @entity465 titres and had high sensitivity and specificity in screening for @entity66 . Only in two @entity66 @entity1 were high titres found of IgA-antibodies against factor XIII, non-reactive with @entity8265 . Both lacked @entity548 tendency. The presence of IgG-antibodies against @entity8265 , in contrast, had low sensitivity and specificity in screening for @entity66 and were frequently seen in @entity29 . Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in @entity1 with @entity30 and in both @entity465 -negative and positive @entity1 . Despite a marked homology with @entity8265 , the occurrence of high titre IgA-antibodies against factor XIII is infrequent in @entity66 , but may-when present-be the result of epitope spreading. The presence of IgG-antibodies in @entity66 and @entity29 illustrates the complexity of autoantibody reactions in @entity344 .
