REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by XXXX .

@entity1 @entity41993 @entity1527 @entity1526 @entity281 @entity14813
It has been shown that the invasive trypomastigote forms of @entity1527 use and modulate components of the extracellular matrix (ECM) during the initial process of @entity281 . Infective trypomastigotes up-regulate the expression of laminin y-1 ( @entity41993 ) and thrombospondin (THBS1) to facilitate the recruitment of trypomastigotes to enhance cellular @entity281 . Silencing the expression of @entity41993 and THBS1 by stable RNAi dramatically reduces trypanosome @entity281 . @entity1527 gp83, a ligand that mediates the attachment of trypanosomes to cells to initiate @entity281 , up-regulates @entity41993 expression to enhance cellular @entity281 . Infective trypomastigotes interact with @entity41993 through galectin-3 ( @entity14813 ), a @entity1 lectin, to enhance cellular @entity281 . Silencing the expression of @entity14813 also reduces cellular @entity281 . Some trypanosome surface molecules also interact with the ECM to facilitate @entity281 . Despite the role of the ECM in @entity1527 @entity281 , almost nothing is known about the ECM interactome networks operating in the process of @entity1527 @entity281 . In this mini review, we critically analyze and discuss the regulation of the ECM by @entity1527 and its gp83 ligand, and present the first elucidation of the @entity1 ECM interactome network, regulated by @entity1527 and its gp83 ligand, to facilitate cellular @entity281 . The elucidation of the @entity1 ECM interactome regulated by @entity1527 is critically important to the understanding of the molecular pathogenesis of @entity1527 @entity281 and developing novel approaches of intervention in @entity1526 .
