Blood group-related antigens in @entity1 germ cell XXXX .

@entity1 @entity5 @entity2970 @entity189 @entity20604 @entity10711 @entity4797
With the use of immunohistochemical techniques, seven mouse monoclonal antibodies and the lectin from Ulex europaeus, detecting blood group antigens of the @entity20604 and Lewis systems, have been used to define the distribution of these antigenic structures in germ cell @entity5 . The reagents used recognize the following blood group antigens: A, B, H, Lewisa, Lewisb, X (Lewisx), Y (Lewisy), and type I precursor antigen. @entity5 from 29 @entity1 were studied. @entity5 studied consisted of pure @entity189 for eight @entity1 , pure @entity2970 for two @entity1 , @entity189 plus @entity2970 in one @entity1 , and yolk sac @entity5 in one @entity1 . Also studied were nine classic @entity4797 and a group of six @entity1 with @entity5 classified as @entity4797 that exhibited atypical histological features. One @entity1 had an @entity189 arising from the mediastinum which could not be conclusively identified as a germ cell @entity5 morphologically and was analyzed separately. All @entity189 and @entity2970 exhibited strong positivity for type I precursor structure as detected by the K-21 monoclonal antibody. In marked contrast, there was non staining in classic @entity4797 but heterogeneous staining in five of six @entity4797 . The majority of @entity189 and all @entity2970 studied demonstrated strong positivity for blood group antigen H. For @entity4797 , however, only one of the atypical cases and two of the classic cases (occasional cells) stained for H. Focal expression of the Y antigen was identified in 5 of 17 @entity4797 and in the majority of @entity189 and @entity2970 . Two @entity2970 and two classic @entity4797 expressed blood group X. The remaining blood group antigens were not expressed by @entity4797 while they were variably expressed by @entity189 and @entity2970 . These data suggest that K-21 and blood group antigen H may be distinguishing markers of @entity10711 . If so, it is possible that the heterogeneous expression of blood group substances in @entity4797 with atypical histologies is an indication of differentiation towards @entity10711 .
