Skeletal muscle morphology in @entity6288 defined using the EWGSOP criteria: findings from the XXXX ( @entity6288 ).

@entity1 @entity6288
BACKGROUND: @entity6288 is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with @entity6288 among community dwelling older @entity1 . METHODS: One hundred and five @entity1 aged 68-76 years were recruited to the @entity6288 ( @entity6288 ) for detailed characterisation of muscle including measures of muscle mass, strength and function. Muscle tissue was obtained from a biopsy of the vastus lateralis for 99 @entity1 and was processed for immunohistochemical studies to determine myofibre distribution and area, capillarisation and satellite cell (SC) density. RESULTS: Six (6  %) @entity1 had @entity6288 as defined by the European Working Group on @entity6288 in Older @entity1 (EWGSOP) criteria. These @entity1 had lower SC density (1.7 cells/mm(2) vs 3.8 cells/mm(2), p   =   0.06) and lower SC/fibre ratio (0.02 vs 0.06, p   =   0.06) than @entity1 without @entity6288 . Although @entity1 with @entity6288 tended to have smaller myofibres and lower capillary to fibre ratio, these relationships were not statistically significant. CONCLUSION: We have shown that there may be altered muscle morphology parameters in older @entity1 with @entity6288 . These results have the potential to help identify cell and molecular targets for therapeutic intervention. This work now requires extension to larger studies which also include @entity1 .
