Combination of @entity1161 therapy for XXXX and @entity511 of the skull base: the Centre de Protonth  rapie D'Orsay experience.

@entity1 @entity511 @entity137 @entity5 @entity1161 @entity3580
PURPOSE: Prospective analysis of @entity5 control, survival, and treatment complications in 44 consecutive @entity1 treated with fractionated @entity1161 for a @entity3580 or @entity511 of the skull base. METHODS AND MATERIALS: Between December 1995 and December 1998, 45 @entity1 with a median age of 55 years (14-85) were treated using a 201-MeV proton beam at the Centre de Protonth  rapie d'Orsay, 34 for a @entity3580 and 11 for a @entity511 . Irradiation combined high-energy photons and protons. Photons represented two-thirds of the total dose and protons one-third. The median total dose delivered within the gross @entity5 volume was 67 cobalt Gray equivalent (CGE) (range: 60-70). RESULTS: With a mean follow-up of 30.5 months (range: 2-56), the 3-year local control rates for @entity3580 and @entity511 were 83.1% and 90%, respectively, and 3-year overall survival rates were 91% and 90%, respectively. Eight @entity1 (18%) failed locally (7 within the clinical @entity5 volume and 1 unknown). Four @entity1 died of @entity5 and 2 others of intercurrent disease. In univariate analysis, young age at time of radiotherapy influenced local control positively (p < 0.03), but not in multivariate analysis. Only 2 @entity1 presented Grade 3 or 4 complications. CONCLUSION: In skull-base @entity3580 and @entity511 , the combination of photons with a proton boost of one-third the total dose offers an excellent chance of cure at the price of an acceptable @entity137 . These results should be confirmed with a longer follow-up.
