Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for XXXX .

@entity1 @entity4 @entity1373 @entity5105 @entity2518 @entity10211
Successful and long-standing eradication of @entity1373 has remained difficult due to the propensity of these lesions to be extensive. Current treatments include excision, electrodesiccation, laser vaporization, and oral @entity10211 , each often associated with unacceptable side effects or lesional recurrence. The purpose of this study was to evaluate the safety and effectiveness of laser-assisted photodynamic therapy using topical @entity2518 ( @entity2518 ) and 595 nm pulsed dye laser (PDL) irradiation for the treatment of @entity1373 . Ten @entity1 with @entity1373 received 1 or 2 treatments at 6 week intervals with topical 20% @entity2518 followed 1 hour later by 595 nm PDL irradiation. Matched lesions served as controls and were either treated with PDL alone or were left untreated. @entity1 were evaluated at regular intervals for 3 months. Results demonstrated that combination topical @entity2518 and PDL treatment effected better clinical results than PDL treatment alone. No changes were observed in untreated control lesions. Side effects were mild and limited to transient @entity5105 , @entity4 , and focal crusting. It is the conclusion of the authors that laser-assisted photodynamic therapy with topical @entity2518 and PDL irradiation can achieve safe and effective improvement of @entity1373 . Further study is warranted to determine the longevity of the clinical results observed.
