Influence of Microvesicles in Breast Cancer XXXX and their Therapeutic Implications.

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Microvesicles are membranous sac structures released from cell surfaces of many eukaryotic cells. Their presence in the blood and urine also signify their potential use as biomarkers for early detection and diagnosis of different diseases. At present, synthesis and release of these vesicles from ma @entity5 ells and their role in disease progression requires further research. In this report, correlation of microvesicles along with br @entity0 e @entity3 as been explored. Me @entity3 s a process of a non-randomized set of events, which begins with a loss of ca @entity5 ell adhesion at the primary tu @entity5 ite. Later on, these cells invade the surrounding tissue and enter into circulation. After compromising host immune response, these cells extravasate and localized at the suitable distant site for a secondary growth. Involvement of microvesicles in modulating this process has also been observed. Microvesicles released from primary ca @entity5 ells may carry mRNA, miRNAs, DNA and various proteins. These vesicles may also influence multi drug resistance as observed in br @entity0 ell lines. A thorough understanding of microvesicles synthesis and their potential implication in me @entity3 ould facilitate the design of novel therapeutic approach for br @entity0
