@entity12098 and XXXX risk: a multipopulation pooled, cumulative exposure analysis.

@entity1 @entity4736 @entity6 @entity5 @entity12098 @entity150 @entity6170
AIMS/HYPOTHESIS: The evidence on the association between @entity12098 use and @entity150 is contradictory, with many studies subject to allocation bias. The aim of our study was to examine the effect of exposure to @entity12098 on @entity150 risk internationally across several cohorts. The potential for allocation bias was minimised by focusing on the cumulative effect of @entity12098 as the primary endpoint using a time-dependent approach. METHODS: Prescription, @entity5 and mortality data from @entity1 with type 2 @entity6 were obtained from six populations across the world (British Columbia, Finland, Manchester, Rotterdam, Scotland and the UK Clinical Practice Research Datalink). A discrete time failure analysis using Poisson regression was applied separately to data from each centre to model the effect of cumulative drug exposure on @entity150 incidence, with time-dependent adjustment for ever use of @entity12098 . These were then pooled using fixed and random effects meta-regression. RESULTS: Data were collated on 1.01 million @entity1 over 5.9 million @entity1 -years. There were 3,248 cases of incident @entity150 , with 117 exposed cases and a median follow-up duration of 4.0 to 7.4  years. Overall, there was no evidence for any association between cumulative exposure to @entity12098 and @entity150 in @entity1 (rate ratio [RR] per 100  days of cumulative exposure, 1.01; 95% CI 0.97, 1.06) or @entity1 ( @entity4736 .04; 95% CI 0.97, 1.11) after adjustment for age, calendar year, @entity6 duration, smoking and any ever use of @entity12098 . No association was observed between @entity6170 and @entity150 in @entity1 ( @entity4736 .01; 95% CI 0.98, 1.03) or @entity1 ( @entity4736 .00; 95% CI 0.94, 1.07). CONCLUSIONS/INTERPRETATION: The cumulative use of @entity12098 or @entity6170 was not associated with the incidence of @entity150 in this large, pooled multipopulation analysis.
