Effects of antithrombogenic agents on microvenous anastomoses in a XXXX model.

@entity1397 @entity117 @entity49 @entity6058 @entity8973 @entity3285 @entity35 @entity715
OBJECTIVE: To compare @entity49 rates among animals treated with @entity117 , @entity1397 , and @entity6058 @entity8973 using an anastomotic "tuck" model. DESIGN: Single-blind randomized animal study. SETTING: An animal laboratory at a tertiary care academic referral center. SUBJECTS: Forty-two retired Lewis breeder @entity35 divided into 3 equal groups. INTERVENTIONS: Before surgical intervention, 1 group received @entity117 (10 mg/kg) through gavage; 1 group, @entity1397 (5 mg/kg) through gavage; and the final group, @entity3285 (3 mg/kg) through intramuscular injection. Each @entity35 was then anesthetized, and the femoral veins were prepared bilaterally. A 180   venotomy was made, and the vessels were anastomosed with the tuck model set-up for anastomotic failure. The vessels were checked for patency every 15 minutes for 2 hours after clamp removal. MAIN OUTCOME MEASURES: The rate of @entity49 and the time to @entity715 . RESULTS: In both the @entity117 and @entity1397 groups, 2 of 28 vessels (7%) were thrombosed. @entity715 occurred in 3 of 28 vessels (11%) in the @entity6058 group (P = .86). All @entity715 in the @entity117 and @entity1397 groups took place at 7.5 minutes after clamp removal. In the @entity6058 group, the mean time to @entity715 was 7.5 minutes (range, 0-22.5 minutes). There was no difference in time to @entity715 among the 3 groups (P = .86). CONCLUSION: Using a microvenous tuck model set-up for anastomotic failure, we found no difference in the rate of @entity715 or the time to @entity715 in @entity35 pretreated with @entity117 , @entity1397 , or @entity6058 .
