The growth endocrine XXXX and @entity32 responses after laparoscopic cholecystectomy.

@entity1 @entity650 @entity32 @entity2301 @entity442 @entity2124 @entity2963 @entity2270 @entity1851
OBJECTIVE: It is well known that conventional surgery leads to detrimental immune and catabolic responses, thus there is growing interest in the effect of minimally invasive techniques on postoperative endocrine and immune function. The aim of this prospective study was to evaluate the @entity2124 (GH)/insulin-like growth factor-1 ( @entity442 )/ @entity2301 ( @entity2301 ) @entity2270 and acute phase ( @entity650 , @entity650 , and @entity1851 , @entity1851 ) responses in @entity1 who underwent laparoscopic cholecystectomy. DESIGN: Twenty-nine @entity1 (16 @entity1 , 13 @entity1 ; age: 58+8 years) with a history of uncomplicated symptomatic @entity2963 participated in the study. Blood samples were collected prior to and at 24 hrs and 48 hrs after laparoscopic cholecystectomy. Serum concentrations of @entity2124 , @entity442 , @entity2301 , and @entity650 were determined by standard sandwich enzyme-linked immunosorbent assay (ELISA), while @entity1851 was measured by nephelometry. ANOVA with repeated measures and Tukey's post-hoc test were used to evaluate changes in serum measurements. RESULTS: The laparoscopic cholecystectomy resulted in a significant postoperative increase in circulating levels of @entity650 (p=0.031), which is the main cytokine responsible for inducing the acute @entity32 response, and of the acute phase protein @entity1851 (p=0.005). A significant increase in @entity2124 levels at 24 hrs (p=0.034) and decrease of @entity442 on both postoperative days were also found (p=0.045, 0.044), while no changes were documented in @entity2301 levels. Significant correlations were revealed between postoperative levels of the acute phase proteins and growth @entity2270 hormones (p<0.05 - 0.001). CONCLUSIONS: Our findings suggest that laparoscopic cholecystectomy induces acute phase endocrine and immune responses. These changes may represent a state of systemic @entity32 and @entity2124 resistance, compatible with possible cytokine-induced anti-anabolic or catabolic effects even after this minimally invasive cholecystectomy.
