Severe @entity2147 after pituitary/ XXXX surgery in adolescents: clinical characteristics and potential mechanisms.

@entity1 @entity2338 @entity28 @entity1640 @entity27 @entity1955 @entity2147 @entity2339 @entity977 @entity701 @entity25
OBJECTIVES: After resection of @entity2339 , @entity1 are at risk for development of @entity2338 , @entity28 , and @entity2147 . However, the prevalence and pathophysiology of these complications are unclear. The purpose of this study was to assess the prevalence and severity of @entity2147 in @entity1 after resection of @entity977 and to study the potential factors that contribute to this @entity25 if present. We further hypothesized that decrements in orexin levels may contribute to the @entity25 . METHODS: Six @entity1 who underwent @entity1640 /pituitary surgery were identified. Five of these @entity1 and 5 matched control subjects underwent overnight polysomnography followed by a multiple sleep latency test. @entity1 who had a primary @entity25 ( @entity27 ) underwent treatment and were restudied subsequently (n = 2). Blood levels of pituitary hormones were measured. Blood and cerebrospinal fluid (CSF) were drawn from 4 @entity1 and 3 control subjects to measure orexin levels. RESULTS: Endocrine control was appropriate in all @entity1 . Although @entity1 had longer sleep duration but similar sleep efficiency than control subjects, relatively severe daytime somnolence was present (mean sleep latency: 10.3 +/- 5.3 minutes vs 26.2 +/- 1.1 minute in control subjects). Sleepiness did not correlate with body mass index or age. Furthermore, serum and CSF orexin levels did not differ between @entity1 and control subjects. CONCLUSIONS: Severe @entity25 is frequent among @entity1 who undergo pituitary/ @entity1640 surgery and does not seem to result from inappropriate @entity701 or @entity1955 replacement, disturbed nocturnal sleep, or low levels of orexin in the serum or CSF. We therefore speculate that other, unidentified neurohormonal mechanisms may mediate the excessive @entity25 of these @entity1 .
