Motor complications in an incident XXXX cohort.

@entity1 @entity3034 @entity304 @entity5834 @entity910 @entity191 @entity400 @entity285
BACKGROUND AND PURPOSE: @entity3034 treatment in @entity191 ( @entity191 ) causes motor fluctuations and @entity910 , but few data describe their development or severity in unselected incident cohorts. METHODS: Demographic, clinical, treatment, smoking, @entity5834 and @entity285 data from 183 @entity1 with @entity191 were gathered from the @entity304 Incidence in Northeast Scotland (PINE) study, a community-based, incident cohort. With Kaplan-Meier survival analysis and Cox regression modelling the development, and severity, of @entity910 and motor fluctuations and which factors independently influenced their onset were assessed. RESULTS: After a mean follow-up of 59  months, 39 @entity1 (21.3%) developed motor fluctuations and 52 (28.4%) developed @entity910 . Kaplan-Meier estimates of the probability of motor fluctuations and @entity910 after 5  years of dopaminergic treatment were 29.2% [95% confidence interval (CI) 21.5%-38.8%] and 37.0% (95% CI 28.5%-47.1%) respectively. 19.8% developed motor fluctuations requiring treatment changes but only 4.0% (95% CI 1.5%-10.4%) developed @entity910 requiring treatment changes by 5  years. Cumulative @entity3034 dose [hazard ratio (HR) 1.38 (95% CI 1.19-1.60)], female sex [HR 2.41 (1.19-4.89)] and younger age at diagnosis [HR 1.08 (1.04-1.11)] were independently associated with development of motor fluctuations. Cumulative @entity3034 dose [HR 1.23 (1.08-1.40)] and female sex [HR 2.51 (1.40-4.51)] were independently associated with @entity910 . In exploratory analyses, moderate @entity5834 exposure was associated with fewer motor fluctuations, longer symptom duration with more @entity910 , and @entity400 at diagnosis with higher rates of both complications. CONCLUSIONS: In this community-based incident @entity191 cohort, severe @entity910 were rare. Cumulative @entity3034 dose was the strongest predictor of both @entity910 and motor fluctuations.
