Role of Right @entity67 in Predicting Early and Long-Term Mortality in Cardiac Resynchronization Therapy XXXX .

@entity1 @entity712 @entity7086 @entity67 @entity4266
BACKGROUND: Right ventricular (RV) dysfunction has been associated with poor prognosis in @entity712 ( @entity712 ). However, less data is available about the role of @entity67 in @entity1 with cardiac resynchronization therapy (CRT). We aimed to investigate if @entity67 would predict outcome in CRT. DESIGN: We enrolled prospectively ninety-three consecutive @entity712 @entity1 in this single center observational study. All @entity1 underwent clinical evaluation and echocardiography before CRT and 6 months after implantation. We assessed RV geometry and function by using speckle tracking imaging and calculated strain parameters. We performed multivariable Cox regression models to test mortality at 6 months and at 24 months. RESULTS: @entity67 , characterized by decreased @entity4266 ( @entity4266 ) [10.2 (7.0-12.8) vs. 19.5 (15.0-23.9) %, p<0.0001] and @entity7086 ( @entity7086 ) [15.6 (10.0-19.3) vs. 17.4 (10.5-22.2) %, p = 0.04], improved 6 months after CRT implantation. Increasing baseline @entity4266 and @entity7086 predicted survival independent of other parameters at 6 months [hazard ratio (HR) = 0.37 (0.15-0.90), p = 0.02 and HR = 0.42 (0.19-0.89), p = 0.02; per 1 standard deviation increase, respectively]. @entity4266 proved to be a significant independent predictor of mortality at 24 months [HR = 0.53 (0.32-0.86), p = 0.01], and @entity7086 showed a strong tendency [HR = 0.64 (0.40-1.00), p = 0.05]. The 24-month survival was significantly impaired in @entity1 with @entity4266 below 10.04% before CRT implantation [area under the curve = 0.72 (0.60-0.84), p = 0.002, log-rank p = 0.0008; HR = 5.23 (1.76-15.48), p = 0.003]. CONCLUSIONS: Our findings indicate that baseline @entity67 is associated with poor short-term and long-term prognosis after CRT implantation.
