Multiple evidence for an early age pro-oxidant state in Down Syndrome XXXX .

@entity1 @entity14625 @entity9492 @entity7599 @entity66 @entity270 @entity620 @entity3624 @entity2041 @entity1467 @entity14626 @entity414
@entity66 has been associated with @entity1467 ( @entity1467 ) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of @entity1467 @entity1 aged 2 months to 57 years: (a) leukocyte @entity7599 ( @entity7599 ); (b) blood @entity2041 ; (c) plasma levels of: @entity14626 (Glx) and @entity14625 (MGlx); some antioxidants ( @entity414 , UA, @entity620 , AA and @entity270 ), and @entity3624 oxidase (XO) activity. A significant 1.5-fold increase in @entity7599 levels was observed in 28 @entity1467 @entity1 vs. 63 controls, with a sharper increase in @entity1467 @entity1 aged up to 30 years. The @entity9492 :GSH x 100 ratio was significantly higher in young @entity1467 @entity1 (< 15 years), in contrast to @entity1467 @entity1 aged >or=15 years that showed a significant decrease in the @entity9492 :GSH x 100 ratio ratio vs. controls of the respective age groups. Plasma Glx levels were significantly higher in young @entity1467 @entity1 , whereas no significant difference was detected in @entity1467 @entity1 aged >or=15 years. Unlike Glx, the plasma levels of MGlx were found to be significantly lower in @entity1467 @entity1 vs. controls. A significant increase was observed in plasma levels of UA in @entity1467 @entity1 that could be related to an increased plasma XO activity in @entity1467 @entity1 . The plasma concentrations of AA were also increased in young (< 15 years) @entity1467 @entity1 , but not in older @entity1 vs. controls in the same age range. The levels of @entity270 in @entity1467 @entity1 did not differ from the values determined in control donors. The evidence for a multiple pro-oxidant state in young @entity1467 @entity1 supports the role of oxidative stress in @entity1467 phenotype, with relevant distinctions according to @entity1 ' ages.
