Diagnostic Utility of XXXX and MOC-31 in Distinguishing @entity1358 from Renal Oncocytoma.

@entity5689 @entity1358 @entity1637 @entity703
PURPOSE: @entity703 consist of heterogeneous groups that frequently show complex and overlapping morphology, thus making it difficult to make a correct diagnosis. One of the most problematic differential diagnoses is to distinguish @entity1358 ( @entity1358 ) from @entity1637 . These should be distinguished by differences in their behavior and clinical outcome. Our study was performed to identify whether @entity5689 and MOC-31 are useful immunohistochemical markers for differentiating chromophobe @entity1358 from @entity1637 . MATERIALS AND METHODS: We selected 23 chromophobe RCCs, 8 @entity1637 , and 25 clear cell RCCs and performed immunohistochemical staining for @entity5689 and MOC-31. RESULTS: @entity5689 was positive in 20 (87%) of 23 chromophobe RCCs, 0 of 8 @entity1637 , and 21 (84%) of 25 clear cell RCCs. MOC-31 was positive in 22 (96%) of 23 chromophobe RCCs, 2 (25%) of 8 @entity1637 , and 14 (56%) of 25 clear cell RCCs. There was a statistically significant difference in the expression of @entity5689 and MOC-31 between chromophobe @entity1358 and @entity1637 (p<0.001). In addition, clear cell @entity1358 was also significantly different from @entity1637 in the expression of @entity5689 (p<0.001) and was significantly different from chromophobe @entity1358 in the expression of MOC-31 (p<0.001). CONCLUSIONS: @entity5689 and MOC-31 can be useful markers in the differential diagnosis of chromophobe @entity1358 , @entity1637 , and clear cell @entity1358 .
