Cognitive impact of anticholinergic medication in XXXX : Adding insult to injury?

@entity1 @entity308 @entity1494 @entity73 @entity46057 @entity15
BACKGROUND: @entity73 in @entity15 ( @entity15 ) is well recognized, being documented even in the earliest stages of the disease. @entity46057 ( @entity46057 ) are frequently used to address bladdder symptoms in this population. @entity46057 are known for their deleterious cognitive effects in older individuals; however their potential impact on cognition has received less attention in the context of @entity15 . OBJECTIVE: To explore possible detrimental effects of bladder-directed @entity46057 on cognitive functioning in @entity15 . METHODS: 42 @entity15 @entity1 who had been on classical, bladder-directed @entity46057 for >= 6 months were compared to 46 @entity1 not receiving @entity46057 , in terms of their scores on Symbol Digit Modality Test (SDMT) and Selective Reminding Test (SRT). @entity1 also completed questionnaires for fatigue (Modified Fatigue Impact Scale - MFIS) and @entity308 (Beck Depression Inventory-Fast Screen - BDIFS). RESULTS: @entity1 using @entity46057 showed significantly lower SDMT and SRT scores compared to those not using @entity46057 (p<0.001; t-test). The association of lower cognitive test performance with @entity46057 usage was robust, even when other variables (like age, gender, EDSS, etc.) were considered. CONCLUSION: Our results suggest that chronic use of classical @entity46057 for @entity1494 may have a negative impact on cognitive functioning in @entity15 @entity1 . These potential cognitive side effects need to be considered both in clinical practice and research settings.
