Cardiovascular function and fluid compartments in newborn @entity235 XXXX .

@entity296 @entity548 @entity235 @entity1503 @entity520 @entity1168
@entity548 in the adult disrupts cellular function, resulting in a redistribution of fluids and electrolytes. There is little data about the effects of @entity548 on body fluids in the neonate. The purpose of this study was to determine the effects of @entity548 on cardiovascular function, coronary blood flow, @entity1503 ( @entity1503 ), plasma volume (PV), and extracellular fluid (ECF) volume in newborn @entity235 . Group 1 consisted of 88 @entity235 , 1-20 days old, and group 2 was 81 @entity235 , 3-6 wk old. There is a significantly higher ECF volume in younger (256 +/- 10 ml/kg) compared with older puppies (121 +/- 5 ml/kg). A 40% @entity548 caused ECF to fall less in the younger (-27%) than in the older puppies (-51%), whereas PV and @entity1503 decreased to a similar extent in both groups. After returning shed blood, PV and @entity1503 returned to prehemorrhage values, but there was a 12% deficit in functional ECF volume in both groups. A similar degree of @entity1168 , @entity296 , and @entity520 occurred in both groups during shock and after returning shed blood. Cardiac output and coronary blood flow, measured only in group 2, fell significantly in shock (-60 and -50%, respectively; P less than 0.05) and remained below control values after returning shed blood. Our data indicate that inadequate perfusion of the myocardium and persistent @entity520 impairs cardiac function in newborn shock.
