Surgical management of endobronchial inflammatory XXXX .

@entity5 @entity1 @entity1224 @entity1353
BACKGROUND: Endobronchial @entity5 are @entity5 composed of clonal populations of smooth muscle cells and a variable lymphocytic inflammatory component. They represent a challenge with respect to diagnosis, classification, and surgical resection due to their infrequent occurrence. METHODS: We retrospectively reviewed our experience with @entity1 who had @entity5 in the major airways over a 15-year period, in order to understand the incidence, natural biology, treatment, and long-term outcome of individuals with this type of @entity5 in an endobronchial location. RESULTS: Between 1995 and 2010, 11 @entity1 (9 female, 2 male) underwent surgical resection of a @entity5 arising within the tracheobronchial tree. The mean age was 39.6 years (range, 22.3 to 53.6 years). All @entity1 were symptomatic, with cough and @entity1353 as the most common presenting complaints. Rigid bronchoscopy with endobronchial biopsy was utilized to establish the diagnosis in 9 of 11 @entity1 . Laser-mechanical debulking was performed to relieve @entity1224 prior to operation in 10 of 11 @entity1 . Because of wide submucosal infiltration of the @entity5 , surgical resection for complete removal was required for all individuals. Tracheal resection was performed in 3 @entity1 , carinal resection in 1 @entity1 , mainstem bronchial resection in 2 @entity1 , sleeve resection in 3 @entity1 , bilobectomy in 1 @entity1 , and right lower lobectomy in 1 @entity1 . Resection with @entity5 -free margins was accomplished in all @entity1 . Mean @entity5 size was 2.3 cm (range, 1.5 to 3.5 cm). There were no operative deaths, with all @entity1 alive and disease-free at a mean of 6.1    3.7 years. CONCLUSIONS: Complete surgical resection of inflammatory @entity5 presenting in a major airway is safe and leads to excellent survival for @entity1 with this uncommon disease.
