Peripheral chemoreflex sensitivity and sympathetic nerve activity are normal in XXXX divers during training season.

@entity1 @entity64 @entity26 @entity27 @entity519 @entity386
@entity386 divers are exposed to repeated massive arterial @entity26 desaturation, which could perturb chemoreflexes. An earlier study suggested that peripheral chemoreflex regulation of sympathetic vasomotor tone and ventilation may have recovered 4 or more weeks into the off season. Therefore, we tested the hypothesis that peripheral chemoreflex regulation of ventilation and sympathetic vasomotor tone is present during the training season. We determined ventilation, heart rate, blood pressure, cardiac @entity64 volume, and muscle sympathetic nerve activity (MSNA) during isocapnic @entity519 in 10 breath hold divers and 11 matched control subjects. The study was carried out at the end of the season of intense @entity386 trainings. Baseline MSNA frequency was 30+/-4bursts/min in control subjects and 25+/-4bursts/min in breath hold divers (P=0.053). During @entity519 burst frequency and total sympathetic activity increased similarly in both groups. Sympathetic activity normalized during the 30-minute recovery. @entity519 -induced stimulation of minute ventilation was similar in both groups, although in divers it was maintained by higher tidal volumes and lower breathing frequency compared with control subjects. In both groups, @entity519 increased heart rate and cardiac output whereas total peripheral resistance decreased. Blood pressure remained unchanged. We conclude that peripheral chemoreflex regulation of ventilation and sympathetic vasomotor tone is paradoxically preserved in @entity386 divers, both, during the off and during the training season. The observation suggests that repeated arterial @entity26 desaturation may not be sufficient explaining sympathetic reflex abnormalities similar to those in @entity27 @entity1 .
