Severity of hypoperfusion in distinct brain regions predicts severity of XXXX in different reference frames.

@entity1 @entity64 @entity550 @entity132 @entity63 @entity71
BACKGROUND AND PURPOSE: Hemispatial neglect is among the most common and disabling consequences of right hemisphere @entity64 . A variety of variables have been associated with the presence or severity of neglect but have not evaluated the independent effects of location, severity, and volume of @entity63 . Few have determined areas involved in different types of neglect. We identified the contributions of these variables to severity of viewer-centered versus stimulus-centered neglect in acute ischemic right hemisphere @entity64 . METHODS: We studied 137 @entity1 within 24 hours of @entity64 onset with MR diffusion- and perfusion-weighted imaging and a test of @entity132 that distinguishes between viewer-centered and stimulus-centered neglect. Using multivariable linear regression, we identified the independent contributions of severity of @entity63 in specific locations, volume of @entity63 , and age in accounting for severity of each neglect type. RESULTS: Severity of hypoperfusion in angular gyrus was the only variable that significantly and independently contributed to severity of viewer-centered neglect. Volume of dysfunctional tissue and hypoperfusion in @entity550 also accounted for some variability in severity of viewer-centered neglect. Severity of hypoperfusion of superior temporal cortex was the only variable that independently and significantly contributed to severity of stimulus-centered neglect. CONCLUSIONS: Location, severity, and volume of @entity63 together determine the type and severity of neglect after right hemisphere @entity64 . Results also show that perfusion-weighted MRI can be used as a semiquantitative measure of tissue dysfunction in acute @entity64 and can account for a substantial proportion of the @entity71 in the acute stage.
