Long-term treatment of XXXX : results of a randomized controlled trial.

@entity1 @entity1744 @entity102 @entity12593
To examine the long-term management of @entity1744 we conducted a two-part controlled therapeutic trial on 28 @entity1 who had recovered completely after four to six weeks of treatment with ispaghula husk and @entity12593 . In part I @entity1 were randomly divided into two groups. Group A received a placebo capsule while Group B continued with treatment as before. After six months the response to treatment was assessed according to a scoring system. The overall relapse rate in Group B was 46 per cent compared to 82 per cent in group A. With continued treatment @entity1 in Group B became asymptomatic from the fourth month while @entity1 in Group A continued to deteriorate. In part II, @entity1 who had relapsed whilst on placebo received active treatment. Six of the seven who agreed to continue with the study became asymptomatic within four weeks. However, all the @entity1 who were asymptomatic while on active treatment relapsed on discontinuation and again recovered on reinstitution of active treatment. We conclude that @entity1744 is a @entity102 and that treatment with a combination of ispaghula husk and @entity12593 is effective, both in relieving symptoms and in the maintenance of remission.
