Management and Outcomes of XXXX

@entity1 @entity308 @entity353 @entity28 @entity6426 @entity25 @entity3755 @entity10 @entity23695 @entity1771 @entity3119 @entity221 @entity5550 @entity22
OBJECTIVES: To evaluate the effectiveness and comparative effectiveness of treatments for @entity1 with @entity5550 ( @entity5550 ) and bariatric surgery @entity1 and @entity1 with loss-of-control (LOC) eating. Studies of @entity5550 therapies include pharmacological interventions, psychological and behavioral interventions, or combinations of approaches. We examined whether treatment effectiveness differed in @entity1 subgroups and described @entity221 for @entity5550 and LOC eating. DATA SOURCES: We searched MEDLINE(  ), EMBASE(  ), the Cochrane Library, Academic OneFile, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) through January 19, 2015. Eligible studies included randomized controlled trials (RCTs), nonrandomized trials, meta-analyses, and, for @entity221 , cohort and case-control studies. REVIEW METHODS: Pairs of reviewers independently selected, extracted data from, and rated the risk of bias of relevant studies; they graded the strength of evidence using established criteria. We conducted meta-analysis for some treatment outcomes. RESULTS: Of 52 included RCTs of treatment; 48 concerned @entity5550 therapy. Course-of- @entity221 evidence came from 15 observational studies. We examined four major outcomes: binge eating and abstinence, eating-related psychopathology, weight, and general psychological and other outcomes. Second-generation antidepressants (as a class), @entity1771 (an anticonvulsant), and @entity23695 (a stimulant) were superior to placebo in achieving abstinence and reducing binge episodes and/or binge days and eating-related obsessions and @entity3119 . Second-generation antidepressants decreased @entity308 . @entity1771 and @entity23695 produced @entity353 in study populations whose members were virtually all overweight or @entity28 . A few formats of cognitive behavioral therapy (CBT)   therapist led, partially therapist led, and guided self-help   were superior to placebo in achieving abstinence and reducing binge frequency. CBT for @entity5550 was generally ineffective for reducing weight or @entity308 in this population. Therapist-led CBT was not superior to either partially therapist-led CBT or structured self-help CBT for @entity6426 and weight outcomes. Behavioral weight loss treatment produced greater weight loss than CBT at the end of treatment but not over the longer run. @entity1771 , @entity3755 , and @entity23695 were associated with @entity25 , including @entity22 ; @entity1771 and @entity23695 were associated with sympathetic nervous system arousal and @entity10 . We found no evidence on bariatric surgery @entity1 . Treatments for LOC eating in @entity1 did not achieve superior @entity353 outcomes. Evidence on the course of either @entity221 was limited. Early adolescent @entity5550 and LOC eating predicts such behaviors in the future. CONCLUSIONS: @entity5550 @entity1 may benefit from treatment with second-generation antidepressants, @entity23695 , @entity1771 , and CBT. Additional studies should address other treatments, combinations of treatment, and comparisons between treatments; treatment for postbariatric surgery @entity1 and @entity1 ; and the course of these illnesses.
