Microbes of the tonsils in PFAPA ( @entity221 , @entity3136 , XXXX and @entity3298 ) syndrome - a possible trigger of febrile episodes.

@entity1 @entity3136 @entity3298 @entity7551 @entity794 @entity4091 @entity5132 @entity375 @entity221
UNASSIGNED: @entity221 , @entity3136 , @entity7551 , and @entity3298 (PFAPA) is a @entity221 that is often cured by tonsillectomy (TE). We hypothesized that microbes present in the tonsils may act as a trigger for the activation of inflammasomes and investigated the microbiology of the tonsils in PFAPA @entity1 and controls. We recruited 31 consecutive @entity1 who underwent TE due to PFAPA; 24 @entity1 who underwent TE due to other reasons served as controls. We cultured all the samples for bacteria, mycobacteria, @entity375 , and viruses and used PCR for 15 viruses. Also biofilm formation and histologic findings were identified. The samples of the @entity1 yielded @entity5132 more often than did the controls (16 vs 0%, p  =  0.003). @entity794 occurred in only 10% of the @entity1 , but in 38% of the controls (p  =  0.01). @entity4091 occurred less often in @entity1 than in controls. Biofilm was present in 55% of PFAPA tonsils, but in only 24% of the controls (p  =  0.03). The microbes found in the tonsils of PFAPA @entity1 showed significant differences from those of controls. This may in part explain the efficacy of TE in PFAPA.
