Effects of intravenous immunoglobulins (IVIG) on peripheral blood B, NK, and T cell subpopulations in XXXX with recurrent spontaneous abortions: specific effects on @entity1454 and @entity2940 molecules.

@entity1 @entity404 @entity2940 @entity2686 @entity3138 @entity1050 @entity405 @entity4755 @entity1196 @entity1454 @entity4071 @entity2393 @entity9536 @entity5690 @entity792 @entity1361 @entity16445
Polyspecific IgG given intravenously at high dose (IVIG) are increasingly used as an immunomodulating therapy in @entity792 . However, very few studies have dealt with the action of IVIG on the expression of the leukocyte markers. During a clinical trial in which 13 young and healthy @entity1 received IVIG to prevent unexplained recurrent abortions we have evaluated by flow cytometry the action of IVIG on 17 @entity2686 ( @entity1050 ). We found that the IVIG perfusions (0.5 g/kg) induced an increase in the number of polymorphonuclear and monocyte cells in the peripheral blood. This effect lasted 8 days. The IVIG treatment had no effect upon T cell populations stained with antibodies specific for @entity3138 , CD3, @entity404 , @entity405 and on @entity404 +CD45RA+, @entity404 + @entity2393 +, @entity405 + @entity1361 +, @entity405 + @entity1361 - subpopulations. A weak decrease in the B cell number was observed. The most striking phenomenon was the decrease in the number of @entity2940 + cells, whereas @entity4071 + and @entity4755 + cells were unaltered. By the double-staining technique we showed that @entity2940 + @entity4071 + cells became @entity2940 - @entity4071 + cells. Moreover, IVIG decrease the expression level of the @entity1454 molecule on monocytes and lymphocytes. The other adhesion molecules studied remained steady ( @entity9536 , @entity5690 , @entity16445 , @entity2393 , @entity1361 , and @entity1196 ). This study has shown that IVIG have no effect on 15 of 17 @entity1050 used but downmodulate two adhesion molecules playing a key role in the immune system.
