Management of Invasive XXXX in @entity3052 and the Appropriate Time for Restarting Chemotherapy.

@entity1 @entity2379 @entity2380 @entity3052 @entity364 @entity1778 @entity1398 @entity18111 @entity7143 @entity204 @entity11794
OBJECTIVE: Rapid and effective treatment of invasive @entity364 (IFI) in @entity1 with @entity1778 is important for survival. In this study, we aimed to describe variations regarding clinical features, treatment modalities, time of restarting chemotherapy, and outcome in @entity1 with IFI and @entity3052 ( @entity3052 ). MATERIALS AND METHODS: The charts of all pediatric @entity3052 @entity1 in our clinic between the years of 2001 and 2013 were retrospectively reviewed. All @entity1 received prophylactic @entity2380 during the chemotherapy period. RESULTS: IFI was identified in 25 (14%) of 174 @entity3052 @entity1 . Most of them were in the consolidation phase of chemotherapy and the @entity1 had severe @entity1398 . The median time between @entity1778 diagnosis and definition of IFI was 122 days. Twenty-four @entity1 had pulmonary IFI. The most frequent finding on computed tomography was typical parenchymal nodules. The episodes were defined as proven in 4 (16%) @entity1 , probable in 7 (28%) @entity1 , and possible in 14 (56%) @entity1 . The median time for discontinuation of chemotherapy was 27 days. IFI was treated successfully in all @entity1 with @entity18111 , @entity2379 , @entity11794 , or @entity7143 alone or in combination. Chemotherapy was restarted in 50% of the @entity1 safely within 4 weeks and none of those @entity1 experienced reactivation of IFI. All of them were given secondary prophylaxis. The median time for antifungal treatment and for secondary prophylaxis was 26 and 90 days, respectively. None of the @entity1 died due to IFI. CONCLUSION: Our data show that rapid and effective antifungal therapy with rational treatment modalities may decrease the incidence of @entity204 and that restarting chemotherapy within several weeks may be safe in @entity1 with @entity3052 and IFI.
