Mechanisms of XXXX .

@entity137 @entity56 @entity6715
The skin is an organ most often affected by @entity137 . Because of limited reactivity of the skin, different drugs may induce the same reactions on the skin, even if the same drug may induce different @entity137 . Many of these @entity137 do not include immunological mechanisms, most of them are non-immunological processes. @entity137 which involve an immune system, may appear different times after drug administration. The severity of reactions is not dependent on the time at which adverse drug reaction appeared, even if some life threatening @entity137 appear immediately after a drug administration. Four types of immunological reactions, (according to Cooms and Gell), may be involved in a drug adverse reaction. The first type of reaction (anaphylactic reaction) begins early after drug administration and different severities of the reactions could exist. The second type, known as cytotoxic @entity56 , begins after some minutes to a few hours after a drug administration. Third and fourth types of immunological reactions begin usually hours to days after drug administration. Some types of immunological reactions may begin days to weeks after drug administration. Sensitization to the drugs must be happen early, since re-exposition to the drug leads to the @entity137 . The way of sensitization sometimes determines which immune mechanism will be involved and which clinical reaction will appear. Tests in vivo and in vitro can be used in the diagnosis of @entity137 . All these tests are more or less limited to a false positive or false negative reaction and possibilities of serious reactions in tests. Provocations tests give the most satisfactory results but they may be dangerous and life threatening. We must carefully choose the skin tests and apply them according to the suspected pathomechanism of adverse drug reaction geneses and estimate the usefulness and the risks of the tests. Serious @entity137 (i.e. Sy @entity6715 etc.) should not be tested. Some novel patents will have important implications in administration, diagnosis, and prevention of @entity137 .
