Safety of XXXX as a source of @entity3875 in @entity233 rations.

@entity14282 @entity233 @entity14951 @entity3875
A target animal safety study investigated the effects of providing @entity14951 ( @entity14282 ) as a replacement for @entity3875 in pelleted @entity233 feeds. Five groups of @entity233 were fed diets containing @entity3875 at 68.9 micrograms/kg feed (control) or @entity14282 at concentrations of 49.5 (0.5x), 99 (1x), 495 (5x) or 990 (10x) micrograms @entity14282 /kg feed. The effects of @entity14282 or @entity3875 on performance, health, hematology, gross pathology and tissue concentrations of @entity14282 in female and male @entity233 were compared at 112 days of feeding. There was no significant difference from control in pen body weight in any of the groups. When feed conversion was calculated without taking into account body weights of birds that died during the study, there was no significant difference from control in any of the groups. When feed conversion was corrected for mortality, the only significant effect was that females at the 5x level (495 micrograms @entity14282 /kg feed) had improved feed conversion. Significantly increased mortality occurred during the study in the 10x (990 micrograms @entity14282 /kg feed) male group only. No histomorphologic tissue alterations attributable to dietary administration of @entity14282 were observed in tissues examined at any dietary level of @entity14282 . @entity14282 did not adversely affect animal health at the proposed use level of 99 micrograms/kg feed when replacing @entity3875 in @entity233 rations. The proposed use level also provides at least a 5-fold margin of safety.
