The Neurological Outcome of Isolated PVL and Severe IVH in Preterm XXXX : Is It Fair to Compare?

@entity1 @entity548 @entity245 @entity51 @entity5719 @entity306
OBJECTIVE: We compared the neurological outcome of isolated @entity5719 and severe @entity548 in a cohort of very low birth weight @entity1 born and managed at single tertiary-care center in Saudi Arabia. METHODS: We undertook a descriptive retrospective chart review of the neurological status of very low birth weight @entity1 who were born and managed over a 5-year period at King Abdulaziz Medical City, Riyadh. The neurological outcome of neonates with isolated @entity5719 and severe @entity548 (grades III and IV) was studied and compared in relation to @entity245 and @entity306 . RESULTS: A total of 20 @entity1 with isolated @entity5719 and 26 with severe @entity548 (grades III and IV) were identified for this study. Of 20 @entity1 with isolated @entity5719 , 9 (45%) had good developmental outcome and 11 (55%) had bad developmental outcome. Of 26 @entity1 of severe @entity548 , 14 (54%) had good developmental outcome and 12 (46%) had bad developmental outcome (P  =  0.55). Significant motor @entity51 affecting function is distributed as follows: 11/20 (55%) in the isolated @entity5719 group and 7/26 (27%) in the severe @entity548 group (P  =  0.05). @entity306 was diplegic in 7/11 (64%) and quadriplegic in 4/11 (36%) in the isolated @entity5719 group, and hemiplegic 3/7 (43%), diplegic in 1/7 (14%), and quadriplegic in 3/7 (43%) in the severe @entity548 group (P  =  0.03). Distribution of the neurological outcome according to @entity5719 grade was as follows: for @entity5719 grade I (n  =  8), 6/8 (75%) had good neurological outcome and 2/8 (25%) had bad neurological outcome. In @entity5719 grade II (n  =  4), good neurological outcome was seen in three @entity1 (75%) and bad neurological outcome was seen in one @entity1 (25%). All @entity1 (n  =  8) with @entity5719 grade III had bad outcome (P  <  0.01). CONCLUSION: About half of @entity1 with isolated @entity5719 and severe @entity548 had a poor developmental outcome. However, the severity of @entity306 was greater in the isolated @entity5719 @entity1 and correlates highly with @entity5719 grade. Symmetrical @entity306 is the most common motor deficit associated with isolated @entity5719 , whereas asymmetrical @entity306 is seen exclusively with severe @entity548 .
