Genetic predisposition to XXXX .

@entity1546 @entity1192 @entity1356
INTRODUCTION: The proinflammatory cytokine @entity1192 is a key regulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption. Allele2 of @entity1356 is associated with a four-fold increase in @entity1356 production. The aim of this case-control study was to evaluate the gene polymorphism of @entity1356 in the pathogenesis of endodontic failure. We hypothesized that the gene polymorphism (allele2 of @entity1356 ) would influence host response and enhance inflammatory reactions predisposing to @entity1546 ( @entity1546 ). MATERIALS AND METHODS: Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled. Inclusion and exclusion criteria were applied, and 34 subjects with signs/symptoms of @entity1546 with otherwise acceptable RCT were included. Sixty-one controls showed healing with acceptable RCT. Genomic DNA from buccal mucosa was amplified by polymerase chain reaction followed by restriction fragment length polymorphism to distinguish the alleles of @entity1356 gene polymorphism. RESULTS: A significant difference in the distribution of the polymorphic genotype among cases (70.6%) and controls (24.6%) (P < .001, Pearson   (2)) was shown. CONCLUSIONS: These findings suggest that specific genetic markers associated with increased @entity1356 production may contribute to increased susceptibility to @entity1546 .
