[Unrelated cord blood transplantation for the treatment of XXXX ].

@entity1 @entity1667 @entity1778 @entity2132 @entity618 @entity1583 @entity2098
OBJECTIVES: To investigate the engraftment, survival and @entity2132 ( @entity2132 ) after transplantation of unrelated cord blood for the treatment of childhood and adult @entity1583 . METHODS: Seventeen @entity1 (13 @entity1 and 4 adults) with @entity1583 were enrolled in this study. Twelve @entity1 were transplanted with one unit and 5 with 2 units of cord blood. There were HLA-matched in 6 and HLA-mismatched at 1 approximately 2 loci in 11 @entity1 . Ten @entity1 were transplanted at stable status, 7 at advanced stage of @entity1778 . Conditioning regimens were BU/CY for 13 and CY/TBI for 3 @entity1 . Most @entity1 received additional ATG at a dose of 15 approximately 20 mg x kg(-1) x d(-1) for 3 days. CsA, @entity618 ( @entity2098 ) and @entity1667 were used for @entity2132 prophylaxis. RESULTS: Fourteen @entity1 survived more than 40 days after transplantation were evaluated for engraftment. At day 60 after UCBT, 86% and 71% of the @entity1 showed neutrophil and platelet engraftment, respectively. The time for an absolute neutrophil count > or = 0.5 x 10(9)/L was (21.0 +/- 1.3) days and platelet > or = 20 x 10(9)/L was (39.0 +/- 10.3) days. Four @entity1 developed grade II acute @entity2132 and 2 chronic @entity2132 . Of the 17 @entity1 , 11 were still alive and 8 of them were in event-free status. For the 10 @entity1 transplanted at stable status, 2 year overall survival is 90%, and event-free survival (EFS) 70%. However, for the 7 @entity1 transplanted at advanced stage of @entity1778 , only 2 survived without relapse. Of the 4 adult @entity1 , 2 had sustained engraftment and survived for 18 and 14 months, respectively. CONCLUSIONS: HLA-matched or 1 approximately 2 loci-mismatched UCBT is a feasible procedure to cure a significant proportion of @entity1 or adults with @entity1778 , especially if performed in a favourable phase of disease. Two units of CBT can be used for adult @entity1 if the cell number of one unit is not enough.
