Genetic counseling and testing in families with XXXX .

@entity5 @entity1 @entity694 @entity14
BACKGROUND: Genetic testing to refine @entity5 risk is available. However, little is known about factors affecting the uptake of testing for the most common hereditary @entity694 , @entity14 . This study investigated attitudes, intentions, and uptake of genetic testing within newly identified families with @entity14 . METHODS: Cohort study conducted at the National Institutes of Health between April 15, 1996, and November 20, 1999. Data were collected through questionnaires before semistructured education sessions, individual counseling sessions, and the offer of genetic testing. RESULTS: Of the 111 eligible first-degree relatives, 51% chose to participate in education and individual counseling sessions. Participation was associated with greater numbers of first-degree relatives with @entity5 ; no association was found between participation and personal history of @entity5 . Before education and individual counseling sessions, 64% of @entity1 had heard little about genetic testing for @entity5 ; however, most (97%) stated intentions to pursue testing. Fifty-one percent identified learning about their @entity1 's risks as the most important reason to consider testing. Thirty-nine percent identified the potential effect on their health insurance as the most important reason to not undergo testing. Of the 111 eligible first-degree relatives, 51% chose to undergo genetic testing. @entity1 ' intentions to pursue genetic testing were significantly affected by concerns regarding the ability to handle the emotional aspects of testing and the psychosocial effect on family members. CONCLUSIONS: Genetic counseling and testing offers the potential to focus @entity5 screening resources in individuals truly at increased risk, thereby reducing mortality and morbidity. Fears of discrimination and concerns about psychological and psychosocial issues may present barriers to the use of current @entity5 prevention strategies, including genetic counseling and testing.
