Cytological grading of XXXX on fine needle aspirates and its relation with histological grading.

@entity1 @entity5 @entity0
BACKGROUND: Grading of @entity0 on fine needle aspiration cytology (FNAC) is beneficial for selecting @entity1 for neoadjuvant chemotherapy. AIMS: To grade the @entity0 on FNAC using Robinson grading system and to assess the concordance of cytological grading (CG) with histological grading (HG) using Elston-Ellis modification of Scarff-Bloom-Richardson grading system. MATERIALS AND METHODS: The study was conducted for 1-year, comprising of 50 female @entity1 attending outpatient departments (OPD) as well as admitted in various surgical wards of a teaching hospital, diagnosed as @entity0 . FNAC smears were stained with May-Grunwald-Giemsa and Papanicolaou (Pap) stains and CG was done using Robinson system on Pap stained smears. The results were compared with HG system after resection of @entity5 . RESULTS: Of 50 cases, 14 (28%) cases were graded as grade I, 24 (48%) grade II, and 12 (24%) grade III by CG, whereas 9 (18%), 28 (56%) and 13 (26%) cases were graded as grade I, II and III by HG. The result showed overall 72% concordance of CG with HG, with grade II and grade III showing highest degree of concordance (83.33%), which is comparable to previous studies. Kappa measurement showed a higher degree of agreement in high-grade @entity5 compared with low-grade @entity5 (0.73 in grade III, 0.53 in grade II and 0.39 in grade I). CONCLUSION: Cytological grading is comparable to HG in majority of cases. Because neoadjuvant chemotherapy is becoming increasingly popular as primary treatment modality of @entity0 , CG could be a useful parameter in selecting the mode of therapy and predicting @entity5 behavior.
