[Sympathomimetic component of XXXX renal action in water-saline depletion].

@entity2011 @entity935 @entity1009 @entity1372 @entity1011 @entity413
In 20 healthy subjects hydro-saline depletion was achieved by a 4-day natriuretic treatment associated with hypo-saline diet. @entity935 (DA) was infused in subpressor dose (.1 microgram . kg-1 . @entity1009 ) during sustained hypotonic @entity2011 induced by 5% @entity413 infusion. Four 15-min clearance periods were performed. DA was infused during the 2nd and the 3rd period. The effective renal plasma flow (RPF) as well as the glomerular filtration rate (GFR) were calculated by PAH and @entity1011 clearances, respectively. In our experimental conditions DA produced: a) an increase in the abnormally isoosmotic @entity1372 reabsorption as % of @entity1372 distal load; b) a decrease in both @entity1372 and osmolar clearance; c) an early increase in free water clearance. RPF and GFR decreased not significantly. The present results indicate that DA in hydro-saline depletion helps to preserve the extracellular fluid volume in minimizing the salt and water loss associated with hypotonic @entity2011 . These effects on @entity1372 excretion may be related to sympathomimetic properties acquired by DA in this experimental condition.
