Total joint arthroplasty and the risk of XXXX : a general population, propensity score-matched cohort study.

@entity1 @entity626 @entity571 @entity572 @entity583 @entity1211 @entity570
OBJECTIVE: To replicate recent findings indicating that total knee arthroplasty (TKA) or @entity572 ( @entity572 ) surgery will substantially reduce the risk of serious cardiovascular events among @entity1 with @entity571 . METHODS: A time-stratified, propensity score-matched cohort study was conducted to assess the incidence of @entity583 ( @entity583 ) in a UK general population. The study population included individuals ages >= 50 years who had a UK National Health Service READ code diagnosis of @entity626 (to evaluate TKA) or @entity570 (to evaluate @entity572 ) between January 2000 and December 2012. RESULTS: Among the @entity1 who underwent TKA and their matched non-TKA control subjects (each n   = 13,849), 306 @entity1 and 286 control subjects developed @entity583 during the followup. During the first postoperative month, the risk of @entity583 was substantially increased among the TKA group compared with the non-TKA group (hazard ratio [HR] 8.75, 95% confidence interval [95% CI] 3.11-24.62), and then gradually declined during the subsequent followup. The HR for the risk of @entity583 over the entire followup was 0.98 (95% CI 0.82-1.18). The corresponding HRs for the risk of @entity583 in those who had undergone @entity572 compared with the non- @entity572 group (each n   =   6,063) were 4.33 (95% CI 1.24-15.21) in the first postoperative month and 0.87 (95% CI 0.66-1.15) overall. In analyses using @entity1211 as a positive control outcome, both the first month and overall HRs for the risk of @entity1211 were substantially increased in both the TKA and @entity572 groups. CONCLUSION: These findings provide the first general population-based evidence to indicate that TKA and @entity572 among @entity571 @entity1 are associated with a substantially increased risk of @entity583 during the immediate postoperative period. However, the overall long-term impact of these surgeries was null, unlike the risk of @entity1211 , which remained elevated years after @entity1 had undergone the procedure.
