XXXX -derived microbial production of carcinogenic @entity3094 in achlorhydric @entity4726 .

@entity1 @entity4726 @entity356 @entity375 @entity1068 @entity413 @entity3094
BACKGROUND: @entity3094 is a local carcinogen in the digestive tract in @entity1 . @entity4726 leads to microbial colonization of the stomach, which could enhance microbial production of @entity3094 from @entity1068 . The aim of the study was to study microbial @entity1068 metabolism and @entity3094 production in the stomach of achlorhydric @entity4726 @entity1 . METHODS: For the in vivo study, @entity413 or @entity1068 was infused via a nasogastric tube to the stomach of seven achlorhydric @entity4726 @entity1 and five healthy controls. Gastric juice samples for @entity1068 and @entity3094 determinations and microbial analysis were obtained at 30 and 60 min after the infusions. For the in vitro study, gastric juice samples from 14 @entity4726 @entity1 and 16 controls were obtained during gastroscopy, whereafter the samples were incubated for 2 h with 1% @entity1068 at 37 degrees C and @entity3094 was determined. RESULTS: Minor endogenous @entity1068 and @entity3094 concentrations were detected after @entity413 infusion in the gastric juice of four @entity4726 @entity1 . After @entity1068 infusion, the mean intragastric @entity3094 level of the @entity4726 @entity1 was 4.5-fold at 30 min and 6.5-fold at 60 min compared to controls. In vitro, the difference between the study groups was even higher, 7.6-fold. A vast selection of oral bacterial species and some Enterobacteriaceae and @entity375 were presented in the gastric juice of @entity4726 @entity1 . CONCLUSIONS: Microbial @entity1068 metabolism leads to high intragastric @entity3094 levels after @entity1068 drinking in achlorhydric @entity4726 @entity1 . This could be one of the factors responsible for enhanced @entity356 risk among @entity4726 @entity1 .
