Value of Dynamic Susceptibility Contrast Perfusion MRI in the Acute Phase of Transient XXXX .

@entity1 @entity10931 @entity2730 @entity16
PURPOSE: @entity10931 ( @entity10931 ) is a transitory, short-lasting @entity16 characterized by a sudden onset of antero- and retrograde @entity2730 . Perfusion abnormalities in @entity10931 have been evaluated mainly by use of positron emission tomography (PET) or single-photon emission computed tomography (SPECT). In the present study we explore the value of dynamic susceptibility contrast perfusion-weighted MRI (PWI) in @entity10931 in the acute phase. METHODS: From a MRI report database we identified @entity10931 @entity1 who underwent MRI including PWI in the acute phase and compared these to control subjects. Quantitative perfusion maps (cerebral blood flow (CBF) and volume (CBV)) were generated and analyzed by use of Signal Processing In NMR-Software (SPIN). CBF and CBV values in subcortical brain regions were assessed by use of VOI created in FIRST, a model-based segmentation tool in the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL). RESULTS: Five @entity10931 @entity1 were included (2 @entity1 , 3 @entity1 ). On PWI, no relevant perfusion alterations were found by visual inspection in @entity10931 @entity1 . Group comparisons for possible differences between @entity10931 @entity1 and control subjects showed significant lower rCBF values bilaterally in the hippocampus, in the left thalamus and globus pallidus as well as bilaterally in the putamen and the left caudate nucleus. Correspondingly, significant lower rCBV values were observed bilaterally in the hippocampus and the putamen as well as in the left caudate nucleus. Group comparisons for possible side differences in rCBF and rCBV values in @entity10931 @entity1 revealed a significant lower rCBV value in the left caudate nucleus. CONCLUSIONS: Mere visual inspection of PWI is not sufficient for the assessment of perfusion changes in @entity10931 in the acute phase. Group comparisons with healthy control subjects might be useful to detect subtle perfusion changes on PWI in @entity10931 @entity1 . However, this should be confirmed in larger data sets and serial PWI examinations.
