Macrophage-Colony Stimulating Factor ( @entity6824 ) Predicts XXXX Progression and Mortality.

@entity1 @entity0 @entity5 @entity6823 @entity469 @entity3 @entity6824
BACKGROUND: Macrophage colony-stimulating factor ( @entity6824 ), also known as @entity6824 ( @entity6824 ), and its receptor @entity6823 have been correlated with poor prognosis in many @entity5 types including @entity0 . Herein, we investigated the prognostic impact of @entity6824 and @entity6823 expression in @entity5 epithelial and stromal compartments in primary @entity0 and axillary lymph node @entity3 . In addition, the density of @entity469 + @entity5 -associated macrophages (TAMs) and CD3+ T-lymphocytes was examined. MATERIALS AND METHODS: Tumor tissue was obtained at the time of primary surgery from 68 prior treatment @entity0 @entity1 , 38 with axillary lymph node @entity3 and 30 @entity1 without @entity3 . Digital video analysis was performed on immunohistochemically stained slides. RESULTS: The expression of @entity6824 , @entity6823 and the density of TAMs and CD3+ T-lymphocytes were then correlated to @entity3 and disease-specific mortality. Metastasized primary @entity5 had higher @entity5 epithelial and stromal expressions of @entity6824 (p<0.001 and p=0.002, respectively) and @entity6823 (both p=0.03) compared to non-metastatic @entity5 . Similar findings were made for the density of @entity469 + (p=0.003) and CD3+ cells in the @entity5 epithelium (p<0.001). In multivariate analysis, a high @entity5 epithelial expression of @entity6824 in primary @entity0 predicted mortality (hazard ratio (HR)=8.6, p=0.039). CONCLUSION: High expression of @entity6824 and @entity6823 and high density of TAMs and CD3+ T-lymphocytes were related to @entity0 progression. @entity6824 expression in @entity5 epithelium predicted @entity0 mortality.
