XXXX and mood disturbance after radical prostatectomy: consequences of biochemical evidence of recurrence.

@entity1 @entity263 @entity5 @entity458
PURPOSE: Biochemical recurrence of @entity263 often precedes any clinical sign or symptom of disease recurrence by several years. Thus, @entity1 may have laboratory evidence of recurrence and do not know what it portends in terms of the future disease course. Little is known about the emotional consequences of biochemical recurrence. We compared @entity5 in @entity1 with biochemical recurrence of @entity263 versus those without recurrence. In addition, associations among urinary symptoms, @entity5 were examined. MATERIALS AND METHODS: A survey including the American Urological Association symptom index, a @entity5 measure and the Profile of Mood States was mailed to @entity1 at a urology clinic at a tertiary care hospital in 1999. Of the sample of 270 @entity1 with @entity263 who underwent radical prostatectomy 126 (47%) responded to the mailed survey. A total of 45 @entity1 with biochemical @entity263 recurrence were compared to 81 @entity1 without recurrence. RESULTS: Higher urinary tract symptoms were associated with increased @entity5 (each p <0.05). Biochemical @entity5 recurrence was not independently associated with increased @entity5 . However, @entity1 with biochemical recurrence and more severe urinary tract symptoms reported the highest levels of @entity5 (each p <0.01). CONCLUSIONS: Psychological distress was highest in @entity1 with biochemical recurrence and elevated clinical symptoms. Urinary symptoms may be an important contributor to @entity458 in @entity1 with @entity263 who have biochemical recurrence.
