The effects of beta-estradiol on @entity8496 activity, cell cycle progression and growth factor synthesis in the XXXX cell line.

@entity1 @entity1915 @entity1782 @entity0 @entity5 @entity33415 @entity10242 @entity817 @entity1722 @entity8496
The aim of this study was to test the hypothesis that some of the proliferative effects of steroid hormones on @entity5 cells are mediated by the @entity8496 proto-oncogenes. The @entity1 @entity0 cell line MCF-7 is @entity1782 ( @entity1782 ) positive (+). NCI/ADR-RES is a @entity1 cell line lacking the @entity1782 ( @entity1782 -) that was initially named @entity33415 and @entity817 kinase activities were examined in cell lines treated with beta-estradiol for 24 hours. Increases in @entity10242 and @entity33415 activities were observed after treatment with beta-estradiol in the @entity1782 (+) MCF-7 cells but not in the @entity1782 (-) NCI/ADR-RES cells. In contrast, no significant changes in @entity817 activity were observed. Thus beta-estradiol can induce @entity10242 and @entity33415 activities in @entity1782 (+) cells. In addition, beta-estradiol caused cell cycle progression in MCF-7 cells and an increased proliferative response to beta-estradiol was observed in MCF-7, which overexpressed constitutively-active @entity10242 (MCF/DeltaRaf-1). Increased mRNA levels of the ligand for the @entity1722 receptor, @entity1915 (ARG) were observed after beta-estradiol treatment of MCF-7 cells whereas constitutively higher levels of ARG and its receptor, @entity1722 mRNAs were detected in MCF/DeltaRaf-1 cells. These findings suggest that targeting @entity8496 may prove efficacious in @entity0 therapies.
