@entity21188 XXXX functional variant is associated with microalbuminuria in the general population.

@entity101 @entity28 @entity6 @entity21188 @entity1985 @entity71085 @entity65 @entity454
BACKGROUND: Microalbuminuria is a risk factor for developing @entity454 and @entity65 . Mutations in @entity21188 have been shown to cause @entity1985 . Recently, a functional polymorphism of this gene ( @entity71085 ) was described and associated with a maturity-onset form of @entity1985 . We have investigated whether the carrier status of this novel genetic variant is associated with microalbuminuria in individuals from the general population. METHODS: Demographic, cardiovascular risk factors, and renal phenotypes in 1577 individuals from a cross-sectional-based study were collected following the general guidelines of the WHO-MONICA project (monitoring trends and determinants in @entity65 ). Blood and urine samples were obtained. Microalbuminuria was determined using a semiquantitative protocol, and DNA was extracted from peripheral lymphocytes. RESULTS: A strong association was found between the 229Q allele and microalbuminuria (P= 0.008). The presence of the 229Q allele was still associated with a 2.77-fold increased risk of presenting microalbuminuria even after adjustment for age, ethnicity, @entity101 , @entity28 , and @entity6 in a multiple logistic regression model. In addition, a statistically significant interaction was identified between the presence of the 229Q allele and body mass index (BMI) (P= 0.01), suggesting an additive effect between the 229Q allele and other risk factors for microalbuminuria. CONCLUSION: These data have important implications for the understanding of microalbuminuria in the general population and may contribute to better ways of disease prediction and prevention.
