[Studies on multiple mucosal biopsy in XXXX with bladder cancer. 2. Evaluation on the relationship between the results of multiple mucosal biopsy and recurrence, and the clinical course of cases with @entity189 in situ and micro-invasion of @entity189 in situ].

@entity5 @entity1 @entity189
The predictive value of grade, number of @entity5 and histology of mucosal biopsy for @entity5 recurrence, the course of @entity189 in situ were examined. The Kaplan-Meier's method was used for the estimation of the recurrence-free rate in the @entity1 who had undergone transurethral resection (TUR) and the logrank test for testing the significance of difference in recurrence-free rate. The 5-year recurrence-free rate was 32.2%. The recurrence-free rate was 51.0% after 40 months postoperatively in @entity1 with a @entity5 , 12.8% after 42 months postoperatively in those with @entity5 . The @entity1 with a @entity5 had a significantly higher recurrence-free rate than those with @entity5 (P less than 0.001). The recurrence-free rate was analyzed according to the grade of main @entity5 , but significantly difference was not present. The recurrence-free rate was 44.4% after 42 months postoperatively in @entity1 with normal histology of mucosal biopsy and 9.5% after 34 months postoperatively in those with abnormal histology. The @entity1 showing normal histology in mucosal biopsy had a significantly higher recurrence-free rate than those with abnormal findings (P less than 0.001). the recurrence-free rate at the same area of biopsy site was analyzed according to the histologies of 537 mucosal biopsies. The recurrence-free rate was 76.7% after 42 months post operatively in areas with a normal biopsy, 44.3% after 35 months postoperatively in those with abnormal histology and the difference was statistically significant (P less than 0.001). Of the 15 @entity1 found to have @entity189 in situ, 4 were @entity189 in situ, 6 were associated with superficial @entity5 and 5 were associated with invasive @entity5 . Thirteen of the 15 @entity1 were alive and free of disease 18 to 42 months later. Two @entity1 associated with invasive @entity5 died 5 and 18 months after transcatheter embolization of internal iliac arteries. Of the 13 @entity1 who were found to have microinvasion of @entity189 in situ, 4 were not associated with visible @entity5 , 6 were associated with superficial @entity5 and 3 were associated with invasive @entity5 . Nine of the 13 @entity1 are alive and free of disease 7 to 53 months later. A @entity1 without any visible @entity5 who was treated with TUR and intravesical chemotherapy died and three @entity1 with invasive @entity5 died irrespective of the mode of treatment.(ABSTRACT TRUNCATED AT 400 WORDS)
