Fatiguing exercise initiated later in life reduces incidence of @entity955 and improves sleep quality in XXXX .

@entity1 @entity64 @entity1295 @entity3207 @entity955 @entity299 @entity121 @entity238
As the @entity1 body ages, the risk of @entity299 and @entity64 greatly increases. While there is evidence that lifelong exercise is beneficial to the heart's health, the effects of beginning exercise later in life remain unclear. This study aimed to investigate whether exercise training started later in life is beneficial to cardiac aging in @entity238 . We examined 4-week-old wild-type virgin female flies that were exposed to exercise periods of either 1.5, 2.0, or 2.5 h per day, 5 days a week for 2 weeks. Using M-mode traces to analyze cardiac function by looking at parameters including heart rate, rhythmicity, systolic and diastolic diameter, and interval and fractional @entity3207 , we found that cardiac function declined with age, shown by an increase in the number of @entity955 events and a decrease in fractional @entity3207 . About 2.0 and 2.5 h of exercise per day displayed a reduced incidence of @entity955 events, and only physical exercise lasting 2.5-h period increased fractional @entity3207 and total sleep time in @entity238 . These data suggested that training exercise needs to be performed for longer duration to exert physiological benefits for the aging heart. Additionally, climbing ability to assess the exercise-induced @entity121 was also measured. We found that 2.0 and 2.5 h of exercise caused exercise-induced @entity1295 , and fatiguing exercise is beneficial for cardiac and healthy aging overall. This study provides a basis for further study in @entity1 on the impact of beginning an exercise regimen later in life on cardiac health.
