Diagnostic and therapeutic management for suspected XXXX .

@entity1 @entity1033 @entity12949 @entity6220 @entity2025 @entity8492 @entity272
BACKGROUND: @entity12949 (HSV) is a rare disease associated with high mortality and morbidity rates. @entity2025 can be subdivided into 3 clinical manifestations: isolated @entity8492 ( @entity8492 ) @entity6220 and disseminated disease. Consensus guidelines for diagnostic and therapeutic management are not available. OBJECTIVES: To evaluate the diagnostic work-up and therapeutic management in neonates with suspected or proven @entity2025 . STUDY DESIGN: Retrospective study of diagnostic and therapeutic management in all neonates with suspected @entity2025 admitted to our neonatal nursery between January 2005 and July 2010. RESULTS: A total 53 neonates with suspected @entity2025 were included in the study and classified as @entity272 (n=2), @entity6220 (n=41) or disseminated disease (n=10). None of the included @entity1 tested positive for @entity2025 . Correct and complete diagnostic work-up was performed in only 11% (6/53) of the cases. All neonates were treated with intravenous @entity1033 . CONCLUSIONS: None of the neonates with suspected HSV tested positive. Diagnostic management in neonates with suspected @entity2025 was often improper and incomplete. Consensus guidelines to identify low-risk @entity1 in whom HSV testing and @entity1033 treatment is not warranted, are urgently needed.
