[Evaluation of the interest of procalcitonin in the diagnosis of @entity5870 in preterm premature XXXX . An observational and prospective study].

@entity1 @entity295 @entity2348 @entity5870 @entity10132 @entity397 @entity2588
INTRODUCTION: Diagnosis of @entity5870 ( @entity5870 ) is difficult because all clinical and biological signs are rarely concordant. According to recent literature, @entity10132 could act as a specific marker of @entity2348 . Our main objective was to assess whether @entity10132 could improve our management of @entity1 with preterm premature @entity397 (pPROM), allowing earlier and more specific diagnosis for @entity5870 . METHODS: @entity1 with pPROM from 24  and 34weeks of @entity2588 were included, from November 2013  to October 2014. @entity10132 was collected twice a week, from pPROM until delivery. Obstetricians were blinded from @entity10132 results, in order not to influence the management of the @entity1 . @entity10132 values were then compared to clinical and other biological diagnostic markers (CRP and white blood cells count [WBC]). RESULTS: Thirty @entity1 were included, with 11  cases of histological @entity5870 and 5  early-onset @entity295 . With a cut-off value of 0.05ng/mL, the sensitivity of @entity10132 to detect histological @entity5870 was 54%, the specificity was 79% and the positive and negative predictive value were respectively 60% and 75%. The positive likelihood ratio was 2.57  and the negative likelihood ratio was 0.58. Using @entity10132 values, our medical decision of foetal extraction would have change in 5  cases (in a wrong way in 3  of them). CONCLUSION: @entity10132 in the diagnostic of @entity5870 is not useful in the management of @entity1 .
