Structural Changes by Spectral Domain Optical Coherence Tomography in XXXX With @entity6 .

@entity1 @entity10911 @entity6 @entity5471 @entity735 @entity1020
BACKGROUND: With a possible increase in the prevalence of @entity6 ( @entity5471 ), the pediatric @entity1 population is expected to be at risk for other health care complications. Current imaging modalities, such as the spectral domain optical coherence tomography (SD-OCT), that allow micron resolution imaging of the retina have become a standard of care for showing morphological changes seen in the retina in adults with @entity6 . Such pathologies can be associated with known risk factors such as poor glycemic control (HbA1C) and body mass index (BMI). METHODS: A comprehensive screening was performed in subjects with @entity5471 including nonmydriatic fundus imaging (Canon, @entity10911 Plus-AF with EOS-60D, Tokyo, Japan) and SD-OCT imaging (Optovue, iVue, Fremont, CA). SD-OCT scans were acquired showing @entity1020 ( @entity1020 ) and thickness of the parafoveal regions and the perifoveal regions. Associations of macular, paramacular, and perimacular thickness were analyzed as a function of HbA1C and BMI by simple linear regressions. RESULTS: SD-OCT changes were analyzed in eyes of subjects with @entity5471 and normal fundus appearance by color imaging. Linear regression analysis of @entity1020 @entity735 ( @entity735 ), paramacula @entity735 , @entity735 (LT), perimacula LT with BMI were statistically significant (P < .05). HbA1C >7.5% was also found statistically significant in the macula @entity735 , paramacula @entity735 , paramacula LT, perimacula @entity735 , and perimacula LT. A general trend of thickening of the macula, paramacula, and perimacula was observed with increasing HbA1C (>7.5%) and increasing BMI; however, no statistical significance was found. CONCLUSIONS: SD-OCT with retinal imaging was feasible in young individuals with @entity5471 and revealed ultrastructural macular and perimacular changes prior to manifest clinical disease.
