XXXX and @entity1887 .

@entity1 @entity8719 @entity1887 @entity2526 @entity1274 @entity179 @entity393
Studies of clinical, audiometric and histological defects in @entity1 with conductive @entity8719 , demonstrated the occurrence of subclinical manifestations in the hair, nails, joints and teeth. Light-microscopic examination of the skin in these @entity1 has shown metachromasia of the ground substance and @entity179 in the collagen and elastic fibres. @entity2526 , in the organs developing from the ectoderm and mesoderm, led to the conclusion that @entity8719 is a universal disease characterized by ectomesodermal insufficiency, a @entity1887 . Optical measurement of the corneal thickness by corneometry has been introduced as an objective method for the diagnosis of @entity1887 . This method, now used routinely in our clinic, shows a high frequency of abnormal corneal thickness among @entity1 with @entity8719 . Such a @entity1 is termed 'cornea-positive'. @entity8719 with pure @entity1274 has been studied by X-ray in axial and semiaxial tomography. These @entity1 were often X-ray positive and among them there were many cornea-positive individuals. Cases with noise-induced @entity393 may also be cornea-positive, i.e. they may exhibit, @entity1887 indicating that their hearing organs are characterized by a decreased resistance to noise. Corneometry has shown its value in the diagnosis of insufficient somatic constitution typical of individuals at risk.
