XXXX with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features.

@entity5 @entity517 @entity4910 @entity1778 @entity1073 @entity7513
The t(11;14)(q13;q32) resulting in @entity4910 overexpression is consistently present in @entity1073 . However secondary chromosomal aberrations are also extremely common. Of these, 8q24 abnormalities associated with the t(11;14) are rare. Over the course of 10 years at M.D. Anderson @entity5 Center, we identified five cases of @entity1073 in which conventional cytogenetic analysis revealed complex karyotypes, including the t(11;14) and 8q24 abnormalities: one with t(8;14)(q24;q32), one with t(2;8)(q13;q24), and three with add(8)(q24). We performed fluorescence in situ hybridization (FISH) studies on all cases. In the case with the t(8;14), @entity7513 /myc fusion signals were identified, and in the case with the t(2;8), split @entity517 signals were detected. In the three cases with add(8)(q24), one case had split @entity517 signals and two cases had three copies of @entity517 . Thus, the @entity517 gene was involved in all cases. All five @entity5 had blastoid morphologic features, and four cases, including the cases with the t(8;14) and t(2;8), had @entity1778 involvement. We conclude that 8q24 abnormalities involving the @entity517 gene are uncommon secondary abnormalities that occur in a subset of @entity1073 . @entity517 gene abnormalities are associated with blastoid cytologic features and also may be associated with @entity1778 involvement.
