HEMOGLOBIN PRODUCTION FACTORS IN THE XXXX LIVER : III. ANEMIAS-PRIMARY, APLASTIC AND SECONDARY-LEUKEMIAS.

@entity1 @entity417 @entity190 @entity2150 @entity1778 @entity7645 @entity68
Biological assay of the @entity1 liver in various types of @entity417 shows conspicuous differences in the concentration of hemoglobin producing factors. @entity7645 shows very high values and the liver in untreated cases may show maximal storage of the hemoglobin producing factors. Liver therapy reduces this store as the missing factor is supplied and new hemoglobin and red cells can be turned out by the marrow. @entity2150 likewise shows high concentration of hemoglobin producing factors as there is no outlet for this material through the red marrow. @entity417 due to @entity190 will show low normal values but even long standing severe @entity417 will not seriously deplete this store of hemoglobin producing factors in the liver. @entity417 due to blood destruction within the body shows higher values and some excess store of hemoglobin producing factors and @entity68 . @entity1778 gives a biological assay like secondary @entity417 due to @entity190 and always presents definite @entity417 . @entity68 analyses show conspicuous differences and @entity68 concentration within the liver parenchyma does not in any way parallel the concentration of hemoglobin producing factors. The highest values for @entity68 concentration are found in @entity2150 (70 mg. per cent)- high values in @entity7645 (51 mg. per cent)-normal values in @entity1778 (13 mg. per cent)-and low values in @entity417 due to @entity190 (5.3 mg. per cent). These findings should aid in a more complete understanding of the pathogenesis and internal metabolism of various @entity417 .
