Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for XXXX .

@entity1 @entity82 @entity41 @entity5 @entity68317
AIMS: The histological modification produced by neoadjuvant chemoradiation on primary @entity5 has been investigated by many authors, and a prognostic value of @entity5 regression grade (TRG) has been identified. Tumor regression grade on metastatic mesorectal lymphnodes has been never evaluated. The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, @entity68317 ) after preoperative chemoradiation in @entity5 @entity1 and to determine the correlation with TRG of @entity5 . METHODS: Surgical specimens from 35 @entity1 who underwent chemoradiation were included. @entity68317 on mesorectal lymphnodes was assessed by immunohistochemistry. Response to treatment was evaluated by a 5-point @entity68317 based on the ratio of @entity41 to @entity82 . RESULTS: Complete pathologic response ( @entity68317 ) was observed in 18 @entity1 (51%). In 4 @entity1 (11%) no regression was observed ( @entity68317 5). In 4 cases only reactive lymphnodes were found. @entity68317 on lymphnodes significantly correlated with TRG on @entity5 (p<0.05). CONCLUSIONS: Neoadjuvant chemoradiation determines a @entity5 regression on mesorectal lymphnodes as on @entity5 ; further studies are needed to evaluate the prognostic value of @entity68317 .
