Genetic Evidence for Possible Involvement of the @entity460 Channel Gene XXXX in Autism Pathogenesis in Chinese Han Population.

@entity10598 @entity245 @entity2438 @entity73308 @entity72 @entity460 @entity73309
UNASSIGNED: @entity72 ( @entity72 ) are a group of @entity245 . Recent studies suggested that @entity460 channel genes might be involved in the genetic etiology of @entity72 . @entity10598 , encoding an alpha-1 subunit of voltage-gated @entity460 channel, has been reported to play an important role in neural development. Previous study detected that a single nucleotide polymorphism (SNP) in @entity10598 confers risk to @entity72 in Central European population. However, the genetic relationship between @entity2438 and @entity10598 in Chinese Han population remains unclear. To explore the association of @entity10598 with @entity2438 , we performed a family-based association study. First, we carried out a family-based association test between twelve tagged SNPs and @entity2438 in 239 trios. To further confirm the association, the sample size was expanded to 553 trios by recruiting 314 additional trios. In a total of 553 trios, we identified association of @entity73308 and @entity73309 with @entity2438 though this would not survive after Bonferroni correction. Our findings suggest that @entity10598 might play a role in the etiology of @entity2438 .
