Erratum: Automated synthesis and dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a radiotracer for imaging of @entity42436 in XXXX .

@entity1 @entity0 @entity2073 @entity42436 @entity35
UNASSIGNED: 6-Deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF) is a promising PET radiotracer for imaging @entity42436 in @entity0 . The present work describes GMP synthesis of 6-[(18)F]FDF in an automated synthesis unit (ASU) and dosimetry calculations to determine radiation doses in @entity1 . GMP synthesis and dosimetry calculations are important prerequisites for first-in- @entity1 clinical studies of 6-[(18)F]FDF. The radiochemical synthesis of 6-[(18)F]FDF was optimized and adapted to an automated synthesis process using a Tracerlab FXFN ASU (GE Healthcare). Starting from 30 GBq of cyclotron-produced n.c.a. [(18)F]fluoride, 2.9    0.1 GBq of 6-[(18)F]FDF could be prepared within 50 min including HPLC purification resulting in an overall decay-corrected radiochemical yield of 14    3% (n = 11). Radiochemical purity exceeded 95%, and the specific activity was greater than 5.1 GBq/ mol. @entity35 were used for biodistribution experiments, and dynamic and static small animal PET experiments. Biodistribution studies served as basis for allometric extrapolation to the standard @entity1 anatomic model and normal organ-absorbed dose calculations using OLINDA/EXM software. The calculated @entity1 effective dose for 6-[(18)F]FDF was 0.0089 @entity2073 /MBq. Highest organ doses with a dose equivalent of 0.0315 @entity2073 /MBq in a @entity1 were found in bone. Injection of 370 MBq (10 mCi) of 6-[(18)F]FDF results in an effective whole body radiation dose of 3.3 @entity2073 in @entity1 , a value comparable to that of other (18)F-labeled PET radiopharmaceuticals. The optimized automated synthesis under GMP conditions, the good radiochemical yield and the favorable @entity1 radiation dosimetry estimates support application of 6-[(18)F]FDF in clinical trials for molecular imaging of @entity42436 in @entity0 @entity1 .[This corrects the article on p. 248 in vol. 4.].
