@entity6337 effects of 635-nm light on @entity235 XXXX cells incubated with @entity2518 .

@entity1 @entity6337 @entity235 @entity2518 @entity1606 @entity13880 @entity150 @entity6053
OBJECTIVE: To determine whether @entity1606 ( @entity1606 ) cells incubated in media containing @entity2518 ( @entity6053 ) would produce sufficient @entity13880 ( @entity13880 ) to cause lethal phototoxic effects when exposed to 635-nm light. SAMPLE POPULATION: @entity235 @entity1606 cells (K9TCC). PROCEDURE: Cultured K9TCC cells were exposed to graded doses of @entity6053 , and @entity13880 concentrations were determined. Cells then were exposed to various doses of 635-nm light from a diode laser, and cell viability was assayed. RESULTS: Production of @entity13880 was dependent on time and dose of @entity6053 . The K9TCC cells incubated with @entity6053 produced sufficient @entity13880 to cause lethal phototoxic effects when exposed to 635-nm light. @entity6337 effects were dependent on time and dose of @entity6053 . Increasing laser power density and energy density decreased cell survival. CONCLUSIONS AND CLINICAL RELEVANCE: @entity6053 is an effective photosensitizer for in vitro photodynamic treatment of K9TCC cells. Further studies are warranted to assess the safety and efficacy of @entity6053 as a photosensitizer for use in treating @entity235 with @entity1606 . Impact for @entity1 Medicine-On the basis of this study, @entity235 with @entity1606 may be useful in the development of protocols for @entity6053 -based photodynamic therapy of @entity1 affected with @entity150 .
