Association of Comorbid Psychopathology With the Duration of XXXX .

@entity1 @entity146 @entity835 @entity1316 @entity5099 @entity74
UNASSIGNED: Risk factors for the development of @entity835 ( @entity835 ) have been well-researched. Comparatively little is known, however, about factors associated with the persistence of @entity835 over time. This research explored whether the temporal sequencing of comorbid @entity146 in relation to the onset of the index @entity5099 episode were associated with the length of this episode. Four comprehensive diagnostic assessments were conducted between ages 16 and 30 with a large and regionally representative community sample (n = 816), among which 173 @entity1 were diagnosed with a lifetime @entity5099 . In separate unadjusted analyses, any internalizing disorder and any @entity1316 with onset prior to that of the index @entity5099 episode were each significantly and negatively associated with @entity5099 duration. These effects, however, were reduced to trend level in adjusted analyses that controlled for putative confounders. Following the onset of the index @entity5099 episode, the subsequent occurrence of any @entity74 , internalizing @entity74 , or other substance use disorder during the index @entity5099 episode was significantly and positively associated with the duration of that episode in both unadjusted and adjusted analyses. These findings collectively suggest that the presence of internalizing-spectrum disorders prior to the onset of the index @entity5099 episode affords some modest protection against protracted episodes, whereas the emergence of broad-spectrum psychopathology within the index @entity5099 episode, most notably noncannabis substance use disorders, is associated with @entity74 persistence. The relevance of these findings for various motivational models of @entity835 is discussed. (PsycINFO Database Record
