@entity1243 and @entity8936 up-regulate XXXX expression in primary cultured normal @entity1 breast pre-adipocytes.

@entity1 @entity172 @entity0 @entity28 @entity1243 @entity6319 @entity4910 @entity8936
Adipocytes account for more than 90% of @entity1 breast volume and secrete adipocytokines, which play a role in @entity0 development. Among the adipocytokines is @entity1243 , which is secreted mainly by adipocytes and plays a key role in @entity0 development. @entity1243 expression is up-regulated in both @entity28 and @entity0 @entity1 , and promotes @entity0 cell growth. Exposure to environmental @entity172 has also been found to be directly related to the development of @entity0 . @entity8936 (Z) is a non-steroidal anabolic growth promoter with estrogenic activity that is widely used in the US beef industry due to its commercial benefits. @entity6319 is a natural compound extracted from cottonseed that inhibits @entity0 growth, and is potentially a chemopreventive food component. This study focused on Z and bio-active Z-containing sera (ZS) collected from Z-implanted beef, and evaluated their adverse health risk to @entity1 . We hypothesized that Z increases the risk of @entity0 in @entity28 @entity1 . A cell proliferation assay, ELISA analysis, RT-PCR and Western blotting were performed to investigate the interaction of @entity1243 , Z and @entity6319 in primary cultured normal @entity1 breast pre-adipocytes. The results indicated that Z and ZS stimulated the growth of pre-adipocytes isolated from normal @entity1 breast tissues by up-regulating @entity4910 expression, while @entity6319 reversed this effect.
