Role of macula densa cyclooxygenase-2 in XXXX .

@entity13586 @entity101 @entity2792 @entity3449 @entity35 @entity4665 @entity8228
Upregulation of the inducible cyclooxygenase ( @entity4665 ) in the macula densa accompanies the activation of the juxtaglomerular apparatus in many high- @entity3449 conditions. The functional role of @entity4665 in these disease states is poorly understood. We tested whether @entity4665 is required to increase @entity3449 in @entity2792 . @entity35 with established two-kidney, one-clip (2K1C) @entity101 were treated for 2 wk with two different inhibitors of @entity4665 , @entity8228 and @entity13586 , respectively. @entity101 in 2K1C @entity35 was not affected or slightly enhanced by @entity4665 inhibition, as measured intra-arterially in conscious animals. The increase in plasma @entity3449 activity was also unchanged by both @entity13586 and @entity8228 . The number of glomeruli with a @entity3449 -positive juxtaglomerular apparatus was elevated in clipped kidneys and decreased in contralateral kidneys of 2K1C @entity35 . This pattern was unaltered by @entity4665 inhibition. To test the effects of @entity4665 blockade on a primarily macula densa-mediated stimulus, we studied salt depletion for comparison. A low-salt diet induced a significant increase in plasma @entity3449 activity, which was partially inhibited by treatment with @entity8228 . We conclude that inhibition of @entity4665 in established @entity2792 does not affect @entity3449 synthesis or release. Thus either @entity4665 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high @entity3449 in @entity2792 .
