Potential for modulation of the fas apoptotic pathway by epidermal growth factor in XXXX .

@entity5 @entity12 @entity242 @entity12020
One important mechanism by which @entity5 cells parasitize their host is by escaping apoptosis. Thus, selectively facilitating apoptosis is a therapeutic mechanism by which oncotherapy may prove highly advantageous. One major apoptotic pathway is mediated by @entity12 ( @entity12 ). The death-inducing signaling Ccmplex (DISC) and subsequent death-domain aggregations are created when @entity12 is bound by its receptor thereby enabling programmed cell death. Conceptually, if a better understanding of the Fas pathway can be garnered, an oncoselective prodeath therapeutic approach can be tailored. Herein, we propose that EGF and @entity12020 play essential roles in the regulation of the Fas apoptotic pathway in @entity242 . @entity5 and in vitro data suggest viable cells counter the prodeath signal induced by @entity12 by activating EGF, which in turn induces prosurvival @entity12020 . The prosurvival attributes of @entity12020 ultimately predominate over the death-inducing @entity12 . Cells destined for elimination inhibit this prosurvival response via a presently undefined pathway. This scenario represents a novel role for EGF and @entity12020 as regulators of the Fas pathway in @entity242 .
