Prognostic factors in XXXX of the lower lip.

@entity1 @entity5 @entity957 @entity189 @entity3
One hundred eighty-seven @entity957 of the lower lip were examined microscopically to identify parameters that might predict @entity3 and @entity1 outcome. Excision specimens of 157 nonmetastasizing @entity189 (group I) were compared with specimens from 30 @entity5 that had metastasized (group II). The following features were recorded: architectural pattern; microscopic thickness (mm); cytologic grade; presence of muscle, nerve, or vessel invasion; inflammatory response; and mitotic rate. The mean thickness was 2.5 mm for group I @entity5 and 7.5 mm for group II @entity5 . Seventy-six per cent of the group I @entity5 were 3 mm thick or less, whereas only one group II lesion (3 per cent) was less than 3 mm thick. Five per cent of the group I @entity5 , compared with 77 per cent of the group II @entity5 , were at least 6 mm thick. Perineural invasion was seen in 5 per cent of the group I and 41 per cent of the group II lesions. Three per cent of the group I @entity189 had a dispersed pattern, compared with 57 per cent of those in group II. One group I lesion (0.6 per cent) and 37 per cent of the group II @entity5 were grade 4. Each of these differences was statistically significant (P less than 0.0001). For all lesions studied, @entity3 had occurred in 60 per cent with perineural invasion, 74 per cent measuring 6 mm or more, 77 per cent with a dispersed pattern, and 92 per cent that were grade 4. These important prognostic variables were best evaluated in the deeper portions of the lesions.
