Prospective Associations Between Early Long-Term Household XXXX Smoke Exposure and Subsequent Indicators of Metabolic Risk at Age 10.

@entity1 @entity286 @entity28
INTRODUCTION: Although there are established risks associated with gestational @entity286 smoke exposure, few studies have addressed the metabolic hazards of domestic exposure in early childhood. This study prospectively examines the long-term relationship between early childhood exposure to household smoke and two adiposity-related measures at age 10. METHODS: @entity1 from the Quebec Longitudinal Study of @entity1 Development birth cohort were categorized into one of three groups of early childhood household exposure to @entity286 smoke over four time points (from ages 1 to 7 years): never-exposed; transient exposure; and continuous exposure. Follow-up measures of body mass index and waist circumference were independently assessed at age 10. RESULTS: Compared to being never exposed, transient and continuous household smoke exposure predicted increases of 0.93cm (95% confidence interval [CI] between 0.05 and 1.82cm; P = .03) and 1.56cm (95% CI between 0.07 and 3.05cm; P = .04) in @entity1 's waist circumference, respectively. @entity1 exposed to transient and continuous household smoke, compared to unexposed @entity1 , also showed 0.48 and 0.81 point increases in their body mass index, respectively, both Ps = .005. Once adjusted, for confounding variables, only transient household smoke remained associated with 43% greater odds of belonging to the overweight/obese category (95% CI between 1.12 and 1.81cm; P < .01). CONCLUSIONS: We found significant long-term prospective associations between home-based secondhand smoke exposure and unhealthy body fat distribution. Waist circumference in youth has become an important risk factor for @entity28 -related diseases in adulthood. Our findings emphasize the importance public health initiatives and parental sensitization aimed at domestic exposure reductions during the critical early childhood years.
