XXXX and autoantibody fixation in an experimental model of @entity121 .

@entity35 @entity121
An experimental model of @entity121 was designed using parental antigens (muscle mitochondrial fraction) in F1 hybrid @entity35 (male @entity35 x female Sprague-Dawley). The immune response was modulated by spleen fragment transplant from either @entity35 (W) or F1. Antibody fixation and inflammatory reaction were studied in Extensor digitorum longus and soleus muscles. Immunization without spleen transplant resulted in antibody fixation mainly in capillaries and incompletely around muscle fibers; whorled fibers were found in 1/3 of F1 @entity35 immunized with antigen from @entity35 . Spleen transplants from Sprague Dawley (SD) @entity35 were usually accepted by F1; in some animals, antibodies surrounded completely muscle fibers and the percentage of animals showing @entity121 was increased. Spleen transplants from non immunized F1 were usually rejected by immunized F1; antibody reaction was found inside fibers of most of the @entity35 , @entity121 was present in 40% of the animals immunized with W, but absent in those immunized with SD antigen. In conclusion, this model can be used to study immunological responses to alloantigens (parental to F1). Spleen fragment transplant modulates the immune response. There was discrepancy between antibody fixation and @entity121 . The immunological response was different according to muscle fiber type composition and/or microcirculatory characteristics.
