Genotypic distribution of common variants of endosomal toll like receptors in healthy Spanish XXXX . A comparative study with other populations.

@entity1 @entity6800 @entity72871 @entity64800 @entity72872 @entity6801 @entity6438 @entity72873 @entity66363 @entity64796 @entity64795 @entity15933 @entity4334 @entity792 @entity22879 @entity15935
UNASSIGNED: Genetic variants of endosomal toll like receptors (TLR) have been associated with many infectious, @entity792 , but few studies have been reported in the Spanish population. The aim of this study was to describe the allelic and genotypic distributions of some common @entity4334 substitutions of endosomal TLRs in healthy Spanish @entity1 and to compare them with those already published in other population groups. Nine substitutions were analysed in 150 DNA samples from 150 Spanish, non-related healthy females: @entity6800 @entity64795 and @entity64796 ; @entity6438 @entity72871 and @entity72872 ; @entity22879 @entity66363 and @entity6801 @entity15933 , @entity15935 , @entity72873 and @entity64800 . Genotyping was carried out by real time PCR and melting curve analysis in a LightCycler 480. A systematic review was performed in order to compare the genotypic distributions in our cohort with those previously published in other population groups. The comparative study was performed with the two tailed Fisher's test or the Yates continuity correction for the Chi-square test when appropriate. No homozygotes for @entity72872 in @entity6438 were found, and @entity72873 and @entity64800 of @entity6801 were in strong linkage disequilibrium. Genotype distributions in endosomal TLR are similar to other Spanish series previously reported. As expected, most differences were found when comparing our distributions with Asiatics, but differences were also found with other Caucasian populations. Since there are significant variations in genotypic distributions of TLRs in both interracial groups and within the same ethnic group, to carry out studies of disease susceptibility in more restricted groups is mandatory.
