Factors affecting reorganisation of memory encoding networks in XXXX .

@entity1 @entity131 @entity410 @entity1315 @entity302 @entity2414
AIMS: In @entity1315 ( @entity1315 ) due to @entity131 reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that modulate memory functions: age at onset of @entity302 , @entity302 duration and @entity410 frequency in a large cohort of @entity1 . METHODS: We studied 53 @entity1 with unilateral @entity1315 and @entity131 (29 left). All @entity1 performed a functional magnetic resonance imaging memory encoding paradigm of faces and words. A continuous regression analysis was used to investigate the effects of age at onset of @entity302 , @entity302 duration and @entity410 frequency on the activation patterns in the memory encoding network. RESULTS: Earlier age at onset of @entity302 was associated with left posterior hippocampus activations that were involved in successful subsequent memory formation in left @entity131 @entity1 . No association of age at onset of @entity302 was seen with face encoding in right @entity131 @entity1 . In both left @entity131 @entity1 during word encoding and right @entity131 @entity1 during face encoding, shorter duration of @entity302 and lower @entity410 frequency were associated with medial temporal lobe activations that were involved in successful memory formation. Longer @entity302 duration and higher @entity410 frequency were associated with contralateral extra-temporal activations that were not associated with successful memory formation. CONCLUSION: Age at onset of @entity2414 encoding in @entity1 with @entity1315 due to @entity131 in the speech-dominant hemisphere. Shorter duration of @entity302 and lower @entity410 frequency were associated with less disruption of the efficient memory encoding network whilst longer duration and higher @entity410 frequency were associated with greater, inefficient, extra-temporal reorganisation.
