Analysis of CAG repeat expansions in XXXX .

@entity1 @entity164 @entity4531
STUDY OBJECTIVES: A relatively high prevalence of @entity4531 has been recently reported in a substantial proportion of @entity1 affected with @entity164 . Our aim was to investigate whether there is a common genetic etiology between @entity4531 and @entity164 . DESIGN: Systematic differences in the number of @entity164 trinucleotide repeat were investigated by means of an association study. The relationship between the size of the expanded alleles and several clinical features was also considered. @entity1 AND SETTING: 125 extensively characterized @entity4531 @entity1 compared with 188 healthy controls matched for ethnic background. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: No CAG repeat expansions in the pathologic or intermediate range were detected in any of the examined subjects, including @entity1 and controls. A similar allelic distribution was observed in both groups (Mann-Whitney U test = 78406; P = 0.99). Moreover, stratification analyses of the @entity1 ' samples according to different clinical and polysomnographic variables disclosed no significant differences. CONCLUSIONS: These results do not provide evidence toward an involvement of large CAG trinucleotide expansions at the @entity164 locus in idiopathic @entity4531 .
