Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among @entity1 with XXXX : a meta-analysis and systematic review.

@entity1 @entity246 @entity353 @entity1176
BACKGROUND/PURPOSE: Gonadotropin releasing hormone( @entity1176 ) as an adjunct to orchidopexy for the treatment of @entity246 is still controversial. Present evidences were studied through a meta-analysis of comparative clinical trials. METHOD: Systematic literature search was done up to September 30, 2013. Studies were independently appraised by two reviewers. Continuous data of fertility indices were extracted as @entity353 ( @entity353 ) and standard deviation (SD); while nominal data of fertility indices were extracted as relative risk (RR). Random effects model was used to analyze the pooled effect estimates. Inter-study heterogeneity and publication bias were assessed. PROSPERO Protocol registration (CRD42013004922). RESULTS: Ten eligible studies were included. The pooled effect estimates showed that cryptorchid @entity1 treated with @entity1176 when compared with controls, have significantly increased germ cell per tubule ( @entity353 : 0.35; 95% CI 0.07-0.62, P=0.01) and increased RR to have normal value of germ cell per tubule (RR: 2.86; 95% CI 1.73-4.71, P<0.0001). Inter-study heterogeneity was noted, source identified with subgroup analysis. Publication bias was not evident. No @entity1176 related adverse events were reported in all studies. CONCLUSION: Evidence suggests that a subset of @entity1 with @entity246 may benefit from @entity1176 as adjunctive to orchidopexy in improving the fertility index. However, future studies are recommended to specifically identify subgroup characteristics of @entity246 that will clearly benefit from the treatment.
