Is a leaky gut involved in the pathogenesis of XXXX ?

@entity1 @entity2656 @entity558 @entity650 @entity13359 @entity11884 @entity1356 @entity310 @entity409 @entity344 @entity969 @entity3645 @entity688
Increased @entity344 has been demonstrated in several @entity409 . It may facilitate the absorption of gut-derived endotoxin-stimulating Kupffer cells to release proinflammatory cytokines or other potentially hepatotoxic compounds. We examined @entity344 , plasma levels of anti-lipopolysacharides (anti- @entity558 ), and four proinflammatory cytokines in 20 @entity1 with @entity13359 ( @entity13359 ) compared with 22 normal pregnant and 29 non-pregnant @entity1 . Urinary excretion of @entity969 and the urinary @entity11884 / @entity2656 (L/M) ratio after a standard oral load were used to assess @entity344 . Anti- @entity558 (IgA, IgM, and IgG) were measured in peripheral blood by @entity1 EndoCAb test kit; @entity310 , @entity1356 , @entity650 , and @entity688 by Quantikine HS @entity1 immunoassays. Sucrose urinary excretion was similar in the three groups, indicating normal gastric permeability. The urinary L/M ratio was significantly higher in @entity13359 than in the other groups [median (interquartile range): 0.018% (0.011-0.023) in @entity13359 , 0.012% (0.009-0.016) in normal pregnancies, and 0.009% (0.008-0.012) in non-pregnant @entity1 , P < .01]. No significant differences were found in anti- @entity558 or cytokines plasma levels except slightly higher levels of @entity650 in @entity13359 @entity1 than in non-pregnant @entity1 (P < .05). Four of five @entity1 with abnormal urinary L/M ratio during @entity13359 continued to show abnormalities in tests up to 2 years after delivery. In conclusion, an increased intestinal permeability was detected in @entity13359 @entity1 during and after pregnancy. A "leaky gut" may participate in the pathogenesis of @entity13359 by enhancing the absorption of bacterial endotoxin and the enterohepatic circulation of cholestatic metabolites of sex hormones and @entity3645 .
