Neurocognitive function and outcome in XXXX : a 10-year follow-up of an epidemiological cohort.

@entity73 @entity149 @entity51 @entity161 @entity74 @entity716
The natural history of @entity149 in @entity161 is unclear. We aimed to characterise this in an epidemiological first-episode cohort and relate it to long-term outcome. All but 1 of 112 first-episode @entity716 cases ascertained from a geographical catchment area were traced at 10-12 years. Neurocognitive and multi-dimensional outcome assessments were made at interview in 49 cases with @entity161 and @entity74 . Twenty-four of these had completed the same @entity149 at index admission. Comparisons with normative data showed @entity73 in a proportion of the first episode (FE) sample at baseline. Significant deterioration was seen over the follow-up period in three of nine sub-tests: object assembly, picture completion and memory for designs. @entity149 at outcome, but not baseline, correlated with clinical outcome. Poor outcome was associated with a decline in performance on visuo-spatial tasks and a failure to improve on frontal-temporal tasks during the follow-up period. @entity51 may be present in the FE, but do not progress over 10-12 years. Visuo-spatial function is spared in the FE but may deteriorate over time. Changes in both these patterned deficits are predictive of clinical outcome.
