OS025. XXXX as a risk factor for hypertensivedisorders of pregnancy in @entity311 endemic regions: A systematic review and meta-analysis.

@entity1 @entity101 @entity281 @entity6866 @entity3964 @entity311
INTRODUCTION: @entity101 ( @entity101 ) are a leading cause of maternal mortality in low and middle income countries (LMICs). @entity101 complicates pregnancy in many malarial endemic areas with the greatest burden in sub-saharan Africa. It has been suggested that there is a link between placental @entity281 (PMI) caused by @entity3964 and @entity101 . To our knowledge, a systematic review has never been conducted on the relationship between PMI and @entity101 and the modification of that relationship with parity. OBJECTIVES: 1. To critically assess the association between PMI and @entity101 among a general obstetrical population in @entity6866 . To evaluate if the relationship between PMI and @entity101 is modified by parity. METHODS: We conducted a systematic review for any study reporting on placental @entity311 and @entity101 . A literature search based on a prospectively prepared protocol was conducted in PubMed Central and EMBASE until 06/09/2011. Additional data on parity of study @entity1 in each study group was requested from corresponding authors of included studies by personal contact through email. Studies were assessed using the Newcastle-Ottawa Scale. The Cochrane Revman 5.1 software was used for statistical analysis according to standardised methodology. Risk Ratios with 95% confidence interval were calculated. RESULTS: Seven studies met our inclusion criteria [1-7]. These included cross-sectional, case control and observational studies. Six were in English and one was translated internally from French. One study [2] was further excluded because it did not represent a general obstetrical population. Our meta-analysis found no association between PMI and @entity101 in a general obstetric population in @entity311 endemic areas [RR of 1.00, 95% CI of 0.82,1.23]. Furthermore, we did not find that this relationship was modified by parity in two studies [RR (nulliparous) 0.92, 95% CI of 0.26,3.25)]. Events= @entity1 with @entity101 (). CONCLUSION: Although trends and associations have been reported in individual studies, we did not find a significant association between PMI and the risk of @entity101 . There is an apparent need for a large prospective cohort study to be conducted on PMI and the possible association with @entity101 .
