Biomarker-based prediction of XXXX -related @entity14 : a case-control study.

@entity32 @entity5 @entity29 @entity876 @entity14 @entity17367 @entity258 @entity1141
BACKGROUND: Regular colonoscopic surveillance for detection of @entity1141 is recommended in longstanding @entity29 ( @entity29 ), however, its sensitivity is disputed. Screening accuracy may increase by using a biomarker-based surveillance strategy. METHODS: A case-control study was performed to determine the prognostic value of DNA ploidy and @entity876 in @entity29 -related @entity5 . Cases with @entity29 -related @entity14 ( @entity14 ), detected in our surveillance program between 1985-2008, were selected and matched with two controls, for age, gender, disease characteristics, interval of follow-up, PSC, and previous surgery. Biopsies were assessed for DNA ploidy, @entity876 , grade of @entity32 and @entity5 . Progression to @entity5 was analyzed with Cox regression analysis, adjusting for potentially confounding variables. RESULTS: Adjusting for age, we found statistically significant Hazard ratios (HR) between development of @entity14 , and @entity258 (HR5.5; 95%CI 2.6-11.5), abnormal DNA ploidy ( @entity17367 .06-1.34, HR4.7; 95%CI 2.9-7.8 and DI>1.34, HR6.6; 95%CI 3.7-11.7) and @entity876 immunopositivity (HR3.0; 95%CI 1.9-4.7) over time. When adjusting for all confounders, abnormal DNA ploidy ( @entity17367 .06-1.34, HR4.7; 95%CI 2.7-7.9 and DI>1.34, HR5.0; 95%CI 2.5-10.0) and @entity876 immunopositivity (HR1.7; 95%CI 1.0-3.1) remained statistically significant predictive of @entity5 . CONCLUSION: In longstanding @entity29 , abnormal DNA ploidy and @entity876 immunopositivity are important risk factors of developing @entity14 . The yield of surveillance may potentially increase by adding these biomarkers to the routine assessment of biopsies.
