CT-guided unilateral thalamotomy with macroelectrode mapping for the treatment of XXXX .

@entity1 @entity2003 @entity191 @entity2845 @entity400
OBJECTIVE: To evaluate the effect of unilateral thalamotomy in @entity1 with @entity191 . METHODS: The junction of the ventralis oralis posterior and ventralis intermedius nuclei targeted under CT-guidance, and confirmed by impedance recording and macrostimulation. RESULTS: At the 6-month assessment the @entity400 has been completely abolished in 37 @entity1 (82.2%), and reduced in 6 @entity1 (13.3%). The Unified @entity191 Rating Scale @entity400 score decreased by 92.5%, @entity2003 improved by 65.9%. Axial symptoms and @entity2845 showed smaller improvement. The levodopa and anti-cholinergic medication significantly reduced. An improvement in the quality of life measured by the @entity191 Questionnaire (PDQ-39) has been observed. The dimensions of mobility, activities of daily living, emotional well being, and stigma were significantly (P<0.05) better, other changes were not significant. The single index improved from 47.8+/-7.8 to 28.9+/-6.3. Transient complications noted in 9 @entity1 (20%), mild persistent morbidity observed in 3 @entity1 (6.7%). At the 1, 2 and 3-year follow-up neither contralateral @entity400 , @entity2003 , nor @entity2845 progression was statistically significant. CONCLUSIONS: CT-guided thalamotomy with macro-electrode mapping provides a safe, effective and long lasting control of @entity400 and @entity2003 , reduces the need for medication, and improves the quality of life.
