Histological changes associated with the use of intravenous @entity205 in the treatment of severe XXXX may mimic @entity1141 .

@entity1 @entity32 @entity31 @entity205 @entity230 @entity1141
BACKGROUND: During six years experience of intravenous @entity205 (i.v. Cy) for severe @entity31 we have noted that changes of villous architecture and epithelial regeneration occur even when the disease fails to enter clinical remission and colectomy is required. OBJECTIVE: To describe the histological changes in @entity1 who received i.v. Cy and @entity230 compared with those treated with i.v. @entity230 alone. @entity1 AND METHODS: Two groups of histological sections were reviewed. The first group was of 23 colectomy specimens from @entity1 who had been treated with i.v. Cy and @entity230 . For 11 @entity1 pre-Cy histological sections were available. The second group was of 10 colectomy specimens from @entity1 who had received i.v. @entity230 alone. Biopsies were scored for their histological disease activity (HDAI), villous architecture and epithelial regeneration. The HDAI assesses the degree of @entity32 . RESULTS: The post-Cy group had higher median scores for villous architecture and epithelial regeneration compared to the pre-Cy and poststeroid groups. For the @entity1 where both pre- and post-Cy histological sections were available 63% increased their villous score post-Cy and 82% increased their epithelial regeneration score post-Cy. CONCLUSION: Although villous transformation and epithelial regeneration may be seen in UC they are more frequent and more severe in those @entity1 who received i.v. Cy and i.v. @entity230 , compared to controls who received i.v. @entity230 alone. These histological changes may mimic @entity1141 . Increased awareness of this potential mimic of @entity1141 is crucial for @entity1 management.
