Exogenous @entity855 disodium administration during primary percutaneous coronary intervention reduces no-reflow and preserves left ventricular function in XXXX with @entity583 : a study using myocardial contrast echocardiography.

@entity1 @entity855 @entity951 @entity583 @entity1002
BACKGROUND: It is unknown whether @entity855 disodium ( @entity855 ) administration during primary percutaneous coronary intervention (PCI) is useful in anterior @entity583 ( @entity583 ). METHODS: The study was a prospective, non-randomized, open-label trial. Primary PCI was successfully performed in 204 consecutive @entity1 with first anterior @entity583 . @entity855 at a mean dose of 117 microg/kg/min for 45 min on an average was infused intravenously during PCI in 100 @entity1 (Group 1). In the other 104 @entity1 , normal saline was administered (Group 2). ST-segment resolution (STR) was estimated 90 min after recanalization. The no-reflow ratio was measured 2 weeks later, using intravenous myocardial contrast echocardiography. @entity1002 ( @entity1002 ), LV regional wall motion (LVRWM), and LV end-diastolic volume index (LVEDVI) were measured 6 months later. RESULTS: Baseline @entity1 characteristics of the two groups were similar, including TIMI risk scores. Significant STR (> or =50% resolution compared to baseline) (66% versus 50%; Group 1 versus Group 2, p=0.02), no-reflow ratio (24% versus 34%, indicated by mean values, p=0.02), @entity1002 (61% versus 55%, p=0.0007), LVRWM (-1.56 versus -2.05, using the SD/chord, p=0.0001), and LVEDVI (60 ml/m(2) versus 71 ml/m(2), p=0.0007) were significantly better in Group 1, and the no-reflow ratio, @entity1002 , LVRWM and LVEDVI were significantly better in @entity855 -administered @entity1 , regardless of antecedent @entity951 or advanced age. @entity855 Administration was consistently identified as a significant determinant for STR, no-reflow ratio, @entity1002 , LVRWM, and LVEDVI. CONCLUSIONS: Intravenous @entity855 administration during reperfusion is an independent determinant of STR and the no-reflow ratio, and @entity1002 , LVRWM, and LVEDVI at 6 months after primary PCI.
