Human health risk assessment of XXXX . I: Toxicology and hazard identification.

@entity95 @entity7452 @entity1304 @entity35 @entity2359
@entity1304 is persistent in the environment and toxic to wildlife. Legal mandates necessitate that a risk assessments be performed for @entity1304 by the @entity7452 ( @entity7452 ) and the United States Environmental Protection Agency (USEPA). This hazard identification (hazard ID) compared critical no-observed effect levels (NOEL) for acute, subchronic and chronic exposure intervals between the agencies. NOELs were discussed in light of their application to numerous exposure scenarios (occupational, general population and dietary). Only the acute oral NOELs differed between @entity7452 (0.7 mg/kg/day) and USEPA (1.5 mg/kg/day). Pregnant @entity95 were considered by @entity7452 to be more responsive to low gavage doses of @entity1304 than non-pregnant female or male @entity35 in the acute study selected by USEPA. NOELs for other exposure routes and durations were similar between agencies. @entity7452 and USEPA concurred that a Food Quality Protection Act (FQPA, 1996) Safety Factor is not needed after evaluating all studies including a Developmental @entity2359 study. The SF was reduced to 1x. NOELs generated from this hazard ID will be used to calculate the Margins of Exposure for all scenarios and subsequently the risk characterization for @entity1304 .
