Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 XXXX .

@entity39 @entity5 @entity16663 @entity1636 @entity3 @entity1758
The definitive diagnostic criteria for malignant @entity16663 are distant @entity3 and/or local invasion. The Weiss histopathologic system is the most commonly used method for assessing @entity5 because of its simplicity and reliability. Unfortunately, its application remains subjective. This current retrospective study evaluated the Weiss system and assessed the value of @entity1758 labeling in the diagnosis of @entity1636 . Twenty-four @entity5 with distant @entity3 , gross local invasion, or recurrence were selected and matched on their functioning status to 25 @entity5 . Two independent observers delineated the Weiss criteria. An @entity1758 labeling index was determined. Presence of three or more Weiss microscopic criteria was related to @entity5 (specificity 96%, sensitivity 100%), thus confirming the value of the Weiss system. Interobserver agreement for the Weiss system (total score) was excellent (r = 0.94). The lack of reliability for some Weiss criteria led us to propose a statistically modified system, based on the most reliable criteria (2.mitotic rate x 2.cytoplasm x abnormal mitoses x @entity39 x capsular invasion) with a significant correlation with the Weiss system (r = 0.98). The @entity1758 labeling index was significantly higher in @entity5 (p <0.0001). @entity1758 could also help to differentiate @entity16663 .
