Low 25-Hydroxyvitamin D Levels Are Associated with Infections and Mortality in XXXX with @entity82 .

@entity1 @entity32 @entity82 @entity14282 @entity409 @entity3851 @entity166 @entity14951 @entity560
BACKGROUND _ AIMS: @entity560 , best known to regulate bone mineralization, has numerous additional roles including regulation inflammatory pathways. Recently, an increased incidence of @entity14951 ( @entity14282 ) deficiency has been found in subjects suffering from @entity409 . We here investigated if low @entity560 levels might be associated with prognosis, @entity32 and @entity166 in @entity1 with @entity82 . METHODS: We performed a prospective cohort study investigating the relation between @entity14282 levels and stages of @entity82 , mortality and complications of @entity82 , including infections. RESULTS: 251 @entity1 with @entity82 were enrolled into the present prospective cohort study. @entity14282 levels were quantified by radioimmunoassay from serum samples obtained at study inclusion. The mean follow-up time was 411    397 days with a range of 1-1382 days. 30 (12.0%) @entity1 underwent liver transplantation and 85 (33.8%) individuals died within the study. The mean serum @entity14282 concentration was 8.93    7.1 ng/ml with a range of 1.0 to 46.0 ng/ml. @entity14282 levels differed significantly between @entity1 Pugh scores and showed a negative correlation with the @entity3851 ( @entity3851 ) score. @entity1 with decompensated @entity82 and @entity166 , had significantly lower @entity14282 levels compared to subjects without complications. Low @entity14282 was associated with mortality in uni- as well as multivariate Cox regression models. CONCLUSIONS: @entity14282 deficiency is associated with advanced @entity409 and low @entity14282 levels are an indicator for a poor outcome and are associated with @entity166 .
