Presence and distribution of biogenic @entity4478 ( XXXX , @entity750 and @entity1425 ) in immunophenotyped @entity1 immune cells.

@entity1 @entity4545 @entity1075 @entity1425 @entity6115 @entity4478 @entity750 @entity112 @entity35
OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity1 immune cells. In an earlier experiment, @entity4545 , endorphin and T(3) were studied and found in different subsets of @entity1 immune cells. Here, three biogenic @entity4478 ( @entity112 , @entity750 and @entity1425 ) were studied. METHODS: Biogenic @entity6115 content of immunophenotyped @entity1 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity6115 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity6115 could be detected in each subset of leukocytes, except @entity1425 and @entity750 in granulocytes. Activated T cells contained a higher amount of the @entity4478 , and @entity1075 +B cells a higher amount of @entity112 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity112 and @entity1425 than lymphocytes and granulocytes contained twice as much @entity112 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity1 lymphocytes contain the three biogenic @entity6115 , similar to @entity35 . However, while each @entity6115 was present in monocytes, in granulocytes @entity750 and @entity1425 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity1 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.
