Temporal Characterization of Marburg XXXX following Aerosol Challenge in @entity2608 .

@entity778 @entity646 @entity4988 @entity37237 @entity7593 @entity57330 @entity73252 @entity51338 @entity54773 @entity1003 @entity36224 @entity281 @entity2629 @entity2608 @entity491
Marburg @entity778 is a lethal @entity7593 for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study, 15 @entity2608 were sequentially sacrificed following aerosol exposure to the @entity37237 , with longitudinal changes in physiology, immunology, and histopathology used to assess disease progression. Immunohistochemical evidence of @entity281 and resulting histopathological changes were identified as early as day 3 postexposure (p.e.). The appearance of fever in infected animals coincided with the detection of serum @entity646 and plasma viral genomes on day 4 p.e. High (>10(7) PFU/ml) viral loads were detected in all major organs (lung, liver, spleen, kidney, brain, etc.) beginning day 6 p.e. Clinical pathology findings @entity1003 , @entity491 , and profound liver destruction as indicated by elevated liver transaminases, @entity2629 , and @entity4988 . Altered cytokine expression in response to @entity281 included early increases in Th2 cytokines such as @entity57330 ( @entity57330 ) and @entity73252 and late-stage increases in Th1 cytokines such as @entity36224 , @entity51338 , and @entity54773 ( @entity54773 ). This study provides a longitudinal examination of clinical disease of aerosol MARV @entity281 in the @entity2608 model. IMPORTANCE: In this study, we carefully analyzed the timeline of Marburg virus @entity281 in nonhuman primates in order to provide a well-characterized model of disease progression following aerosol exposure.
