Glycoprotein IIb-IIIa content and @entity1423 in healthy volunteers and @entity1 with XXXX .

@entity1 @entity1187 @entity1423 @entity1397 @entity117 @entity1427 @entity857 @entity2880
Glycoprotein (GP) IIb-IIIa (aIIbb3-integrin) is the central receptor of @entity1423 . Activated @entity1427 -IIIa binds fibrinogen or @entity2880 factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between @entity1427 -IIIa expression on the platelet surface and platelet aggregating activity. @entity1427 -IIIa number, measured as maximal binding of complex-specific monoclonal antibody, varied by approximately two fold in both healthy volunteers (n   =   35) and @entity1 with @entity1187 ( @entity1187 ) (n   =   65). In healthy volunteers positive associations were observed between @entity1427 -IIIa number and the level of @entity857 -induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of @entity117 or non-saturating concentrations of @entity1427 -IIIa blockers. In the same group of volunteers almost no differences in aggregating activity were detected between donors carrying the GP IIIa Pro33 allele (n   =   15) and those with the GP IIIa Leu33Leu33 genotype (n   =   20). No significant relationships were revealed between @entity1423 and variations of plasma fibrinogen concentration. Positive correlation of the level of @entity857 -induced aggregation and @entity1427 -IIIa content was detected in @entity1 with @entity1187 within the first hour upon admission to the hospital when they had already received @entity117 , but not @entity1397 . However, there were no correlations between these parameters at days 3-5 and days 8-12 (before discharge). At these time points @entity1 were treated not only with @entity117 but were saturated with @entity1397 as well. In @entity1187 @entity1 we also evaluated the expression of another platelet adhesive receptor, GP Ib, and found a significant positive correlation between @entity1427 -IIIa and GP Ib content. A strong association was also revealed between the number of both receptors and mean platelet volume. The latter observation indicated that individual variations of the number of glycoprotein molecules are mainly affected by platelet size but not the density of their expression on the platelet membrane. Possible usefulness of measuring @entity1427 -IIIa content as a marker of increased platelet reactivity is discussed.
