Photodynamic therapy using topical XXXX compared with cryotherapy for actinic keratosis: A prospective, randomized study.

@entity1 @entity4906 @entity1568 @entity19297 @entity5 @entity957
BACKGROUND: Actinic keratoses (AKs) are the most common @entity5 . Without treatment, a significant number of @entity1 with AK will experience @entity957 . Photodynamic therapy ( @entity4906 ) using the new highly selective photosensitizer @entity19297 is a promising new treatment modality for AK. OBJECTIVE: We investigated the complete response rates, cosmetic outcome, and @entity1 satisfaction after photodynamic therapy ( @entity4906 ) using @entity19297 (Metvix) versus cryotherapy in the treatment of AKs. METHODS: @entity1 were randomized to receive either cryotherapy with liquid @entity1568 spray or @entity4906 using @entity19297 cream 160 mg/g, 3 hours application time, and red light (75 J/cm(2)). RESULTS: Efficacy results from 193 @entity1 with 699 lesions (92% face/scalp and 93% thin/moderately thick) were analyzed. Overall complete response rates after 3 months were 69% for @entity4906 and 75% for cryotherapy. Both treatments gave higher response rates in thin lesions ( @entity4906 75%, cryotherapy 80%). @entity4906 gave better cosmetic results and higher @entity1 satisfaction than cryotherapy. CONCLUSION: @entity4906 using @entity19297 is an attractive treatment option for @entity1 with AK, with a response rate similar to that of cryotherapy, but with superior cosmetic results and high @entity1 satisfaction.
