Effects and Safety of XXXX on Neuroprotection: A Meta-analysis Based on PRISMA Guidelines.

@entity1 @entity3152 @entity2399 @entity548 @entity390 @entity2400 @entity5719 @entity1576 @entity204 @entity306
UNASSIGNED: To evaluate the evidence of effects and safety of @entity2399 on neuroprotection for preterm @entity1 who had exposure in uteri.We searched electronic databases and bibliographies of relevant papers to identify studies comparing @entity2399 ( @entity2400 ) with placebo or other treatments in @entity1 at high risk of @entity3152 and reporting effects and safety of @entity2400 for antenatal @entity1 . Then, we did this meta-analysis based on PRISMA guideline. The primary outcomes included @entity204 , @entity306 ( @entity306 ), @entity548 , and @entity5719 . Secondary outcomes included various neonatal and maternal outcomes.Ten studies including 6 randomized controlled trials and 5 cohort studies, and involving 18,655 preterm @entity1 were analyzed. For the rate of moderate to severe @entity306 , @entity2400 showed the ability to reduce the risk and achieved statistically significant difference (odd ratio [OR] 0.61, 95% confidence interval [CI] 0.42-0.89, P = 0.01). The comparison of mortality rate between the @entity2400 group and the placebo group only presented small difference clinically, but reached no statistical significance (OR 0.92, 95% CI 0.77-1.11, P = 0.39). Summarily, the analysis of adverse effects on babies showed no margin (P>0.05). Yet for mothers, @entity2400 exhibited obvious side-effects, such as @entity1576 , @entity390 and so forth, but there exited great heterogeneity. @entity2400 administered to @entity1 at high risk of @entity3152 could reduce the risk of moderate to severe @entity306 , without obvious adverse effects on babies. Although there exit many unfavorable effects on mothers, yet they may be lessened through reduction of the dose of @entity2400 and could be tolerable for mothers. So @entity2400 is both beneficial and safety to be used as a neuroprotective agent for premature @entity1 before a valid alternative was discovered.
