Expression of angiotensin type 1 and 2 receptors in brain after transient XXXX in @entity35 .

@entity64 @entity2806 @entity2500 @entity1809 @entity1808 @entity11082 @entity35
Angiotensin II ( @entity1808 ) type 2 receptors (AT2Rs) have been associated with apoptosis. We hypothesized that AT2Rs are increased in @entity64 and may contribute effects of @entity64 to the brain. To test this, we have examined the expression of @entity1809 ( @entity1809 ), @entity11082 and @entity1808 levels in the brain 24 h after transient @entity2500 ( @entity2500 ). The densities of @entity1809 and @entity11082 were measured by quantitative autoradiography (n=6). The levels of @entity1808 were measured by radioimmunoassay (RIA) (n=6) and by immunohistochemistry (n=3). @entity1809 levels on autoradiography showed a significant decrease (0.87+/-0.06 to 1.39+/-0.07 fmol/mg, p<0.01) in the ventral cortex of the @entity64 side compared to the cortices of non- @entity64 (NS) @entity35 (n=4). There was no significant difference on ATIR in the contralateral verbal cortex of the @entity64 @entity35 compared to NS control. In contrast, levels of @entity11082 in the ventral cortex of both the @entity64 and the contralateral sides were significantly increased (0.77+/-0.06, p<0.05 and 0.91+/-0.05, p<0.01 compared to 0.60+/-0.03 fmol/mg tissue, respectively). RIA showed that @entity1808 in the ventral cortex of both the @entity64 and the contralateral sides were significantly increased (241.63+/-47.72, p<0.01 and 165.51+/-42.59, p<0.05 compared to 76.80+/-4.10 pg/g tissue, respectively). Also, @entity1808 in the hypothalamus was significantly increased (179.50+/-17.49 to 118.50+/-6.65 pg/g tissue, p<0.05). Immunohistochemistry confirmed the increase of @entity1808 . These results demonstrate that brain @entity1808 and AT2Rs are increased whereas AT1Rs are decreased after transient @entity2500 in @entity35 . We conclude that in @entity64 , @entity1808 and @entity11082 are activated and may contribute neural effects to @entity2806 .
