Effects of short-term administration of XXXX on the subgingival microflora.

@entity1 @entity868 @entity548
The effect of a 5-day course of systemic @entity868 was investigated in 11 recall maintenance @entity1 over a period of 3 months. Crevicular fluid flow, @entity548 on probing, pocket depth, and composition of the subgingival microbiota as observed by dark-field microscopy, were measured. The study design allowed @entity1 to act as their own controls. At baseline 1 (day 0), each @entity1 had a randomly assigned quadrant scaled and root-planed, and received oral hygiene instruction. Microbiological and clinical parameters were measured at baseline 1 (before treatment) and at 3, 6, and 12 weeks in both the root-planed and a designated no-treatment quadrant. At baseline 2 (12 weeks), the contralateral quadrant was scaled and root-planed, and the oral hygiene instruction was reinforced. At this appointment, each @entity1 was given 15 @entity868 tablets (250 mg), 1 to be taken 3 times per day for 5 days. At the end of this period, @entity1 were seen 1-2 h after taking their last tablet, and blood and crevicular fluid samples were taken to determine the concentration of @entity868 by microbiological assay in the serum and crevicular fluid. Microbiological and clinical parameters were measured at baseline 2 (before treatment) and at 13, 15, 18, and 24 weeks in both the root-planed and designated non-root-planed ( @entity868 only) quadrants. Results demonstrated that in this group of recall maintenance @entity1 , @entity868 was no more effective than root-planing alone in reducing the relative % of total motile organisms and spirochetes in 5-8 mm pockets. Crevicular fluid flow was, however, significantly reduced for 11 weeks; serum and crevicular fluid levels of @entity868 were similar 1 to 2 h after drug ingestion.
