Molecular pathogenesis of T lymphocyte-induced XXXX in @entity99 .

@entity558 @entity39 @entity167 @entity568 @entity409 @entity1505 @entity8885 @entity35 @entity99 @entity1068
The development of @entity167 -induced @entity99 is, in part, a consequence of the immunological/inflammatory response that @entity167 stimulates. The abnormalities of immune function in heavy drinkers have been documented well. Cytokines, especially @entity1505 , produced from macrophages/Kupffer cells, play a role in the induction of liver cell @entity39 and apoptosis. @entity1505 can cause liver cell apoptosis through the @entity1505 receptor or Fas/CD95 which is expressed by liver cells. Furthermore, chronic @entity1068 consumption may damage the liver by inhibiting the hepatotrophic and hepatoprotective actions of @entity1505 and other cytokines. There exists an intrinsic lymphocyte population in the normal liver. Intrahepatic T lymphocytes consist of a heterogeneous population of cells that has many and varied functional characteristics in addition to classical T cell activity. The population of intrahepatic T lymphocytes may arise via a thymus-independent pathway. Our recent work has demonstrated the role of liver-associated T lymphocytes in the pathogenesis of @entity167 related @entity99 initiated by a variety of stimuli such as endotoxin (lipopolysaccharide, @entity558 ) or concanavalin A (Con A). Our studies have, for the first time, suggested that @entity167 consumption alone does not lead to the development of marked @entity409 (at least in the @entity35 ), but rather that a second insult is required for this to occur. Liver-associated T lymphocytes in @entity35 spontaneously secrete @entity8885 , @entity568 and @entity1505 in vitro culture. There is a significant decline in the amounts of @entity8885 and @entity1505 secreted in @entity1068 -consuming @entity35 compared with non- @entity1068 consuming @entity35 . The numbers of T cells, NK cells and Kupffer cells in liver perfusates remains stable over a prolonged period of @entity1068 consumption. However, following Con A injection, there was an inappropriate increase in the amounts of @entity568 and @entity1505 secreted in in vitro culture of liver-associated T lymphocytes and a significant increase in the percentage of CD4+ T cells and CD25+ T cells in liver perfusates compared with non- @entity1068 consuming @entity35 . It suggested that liver-associated T lymphocytes are involved in the inflammatory process associated with @entity167 related @entity99 through increased cytokine secretion ( @entity1505 ).
