Fractionated stereotactic radiotherapy for large and invasive non-functioning XXXX : long-term clinical outcomes and volumetric MRI assessment of @entity5 response.

@entity1 @entity227 @entity137 @entity5 @entity4611 @entity4614 @entity977
UNASSIGNED: Design: Fractionated stereotactic radiotherapy (FSRT) is frequently employed for the treatment of residual or recurrent @entity977 . We describe our use of FSRT for the treatment of large, invasive, nonfunctioning @entity977 (NFPAs). Methods: Sixty-eight @entity1 with a large residual or recurrent NFPAs were treated between April 2004 and December 2012, including 39 males and 29 females (median age 51 years). @entity227 were present in 34 @entity1 , consisting of @entity227 (n=31) and/or reduced visual acuity (n=12). Forty-five @entity1 had evidence of @entity4614 before FSRT. For most of the @entity1 , the treatment was delivered through 5-10 noncoplanar conformal fixed fields using a 6-MV linear accelerator to a dose of 45 Gy in 25 fractions. Results: At a median follow-up of 75 months (range 12-120 months), the 5-year and 10-year actuarial local control were 97% and 91%, respectively, and overall survival 97% and 93%, respectively. Forty-nine @entity1 had a @entity5 reduction, 16 remained stable, and 3 progressed. The relative @entity5 volume reduction measured using three-dimensional (3-D) magnetic resonance imaging (MRI) was 47%. The treatment was well tolerated with minimal acute @entity137 . Eighteen @entity1 developed @entity4614 . The actuarial incidence of new @entity4611 was 40% at 5 years and 72% at 10 years. No other radiation-induced complications occurred. Conclusions: Our results suggest that FSRT is an effective treatment for large or giant @entity977 with @entity137 .
