Is the antihypertensive effect of XXXX due to volume depletion?

@entity1 @entity1369 @entity101 @entity2178 @entity1372 @entity1613 @entity916 @entity2661 @entity551 @entity17132
Long-term treatment with @entity17132 in @entity1 with essential @entity101 has provided very interesting results. The administration of the drug caused an immediate significant @entity551 which was then maintained for as long as 30 months. The fall in blood pressure was initially associated with a significant decrease in body weight, a clear rise in plasma @entity916 activity (PRA) and a significant increase in plasma @entity1369 concentration; all these changes are consistent with a depletion of extracellular volume and blood volume. With time, however, the mentioned changes were reversed. Body weight, PRA and plasma @entity1369 were normalized after three weeks of treatment and remained normal thereafter. This late observation suggests a normalization in extracellular fluid volume and blood volume, and an antihypertensive effect of the drug independent from volume depletion. How can this effect occur? One possible explanation is a direct vasodilatory effect of @entity17132 which has been shown in experimental animals. Against such a possibility is the unsuccessful treatment of @entity101 in oliguric @entity1 on regular dialysis treatment. A second possibility is a decrease in @entity1372 content of the arteriolar wall with the consequent decrease in vascular response to pressor agents ( @entity2178 , @entity2661 ). A third possibility is a hemodynamic adjustment to the @entity1613 which would normalize cardiac output and peripheral resistances (autoregulation) so that normal blood pressure is maintained as in normal subjects.
