Changes in arterial stiffness but not carotid intimal thickness in XXXX .

@entity1 @entity442 @entity2012 @entity123 @entity731 @entity65 @entity122
CONTEXT: @entity2012 increases @entity65 . We tested the hypothesis that increased arterial stiffness together with left @entity123 may be a contributory factor. @entity1 AND DESIGN: Fifty-six @entity1 (40 males, 54    13 yr; 25 active disease, 31 in remission) and 46 healthy controls (30 males, 52    13 yr) underwent measurements of aortic pulse wave velocity ( @entity122 ), carotid Doppler (IMT), echocardiography, and cardiovascular risk factors. RESULTS: Mean serum @entity442 was 323    286 ng/ml (sd score 1.8    1.9) in all @entity1 . Age, body mass index, diastolic blood pressure (BP), and lipid levels were similar comparing @entity1 and controls. Systolic BP (130.8    19.9 vs. 122    14 mm Hg controls, P < 0.01) and @entity122 (11.7    3.8 vs. 9.7    2.8 m/sec, 95% confidence interval -3.4 to -0.7, P <0.01) were higher in @entity1 than controls. Regression analysis revealed age, presence of @entity2012 , systolic BP, and body mass index, inversely, as significantly and independently associated with @entity122 . No difference in carotid IMT was seen (0.8    0.2 @entity1 vs. 0.7    0.2 mm controls, P = 0.5) or between active/controlled disease. In the subset of @entity1 with echocardiography (n = 32), left ventricular mass was higher by a mean of 38.2 g (95% confidence interval -80.9 to +4.6, P = 0.08). CONCLUSION: In summary, @entity1 with @entity2012 had independently and significantly increased aortic @entity122 as evidence of arterial stiffening but unaltered carotid IMT compared with controls, also influenced by age and systolic BP. Premature @entity65 in @entity1 with @entity2012 is likely related to pressure-related arterial and left ventricular stiffening rather than @entity731 .
