Plasma ghrelin response to an oral @entity413 load in XXXX -deficient adults treated with @entity2124 .

@entity1 @entity2690 @entity2124 @entity3190 @entity413
BACKGROUND: Little is known about the pathophysiology of ghrelin secretion in @entity2124 -deficient adults treated with @entity2124 , and the relationship between plasma ghrelin and @entity3190 induced by an oral @entity413 load has not been investigated in these @entity1 . OBJECTIVE: In the present study we examined the relationship between plasma ghrelin, @entity2690 , C-peptide and leptin after an oral @entity413 load in @entity2124 -deficient adults receiving treatment with @entity2124 . METHODS: Plasma ghrelin, leptin, @entity2690 , C-peptide and blood @entity413 were measured before and then at 30, 60, 90 and 120 min after the ingestion of @entity413 (75 g orally) in 20 @entity2124 -deficient adults (12 @entity1 and 8 @entity1 ), who had been treated with @entity2124 for 7.2 +/- 1.3 years (mean +/- SE). Plasma ghrelin was also determined before and after the @entity413 load in 10 age-and weight-matched healthy @entity1 (5 @entity1 and 5 @entity1 ). RESULTS: The oral @entity413 load induced a similar percent suppression of plasma ghrelin in the @entity2124 -deficient @entity1 and in the healthy @entity1 . In both groups plasma ghrelin decreased significantly 30 min after the @entity413 load and remained suppressed throughout the test period. In the @entity1 plasma @entity2690 (baseline, 15.9 +/- 3.9 microIU/ml) and C-peptide (baseline, 2.5 +/- 0.3 ng/ml) showed opposite changes with peak responses at 30 min ( @entity2690 , 109.5 +/- 15.6 microIU/ml) or 60 min (C-peptide, 10.3 +/- 1.1 ng/ml). In these @entity1 , post- @entity413 , but not baseline plasma ghrelin levels correlated negatively with plasma @entity2690 , C-peptide and blood @entity413 levels, whereas baseline plasma ghrelin correlated inversely with baseline plasma leptin. CONCLUSIONS: The similar suppression of plasma ghrelin in @entity2124 -deficient @entity1 treated with @entity2124 and in healthy @entity1 after an oral @entity413 load argues against disturbed regulation of ghrelin secretion in these @entity1 . The correlations between post- @entity413 plasma ghrelin, @entity2690 and blood @entity413 support the existence of a previously proposed link between @entity3190 (or increased blood @entity413 ) and suppression of ghrelin levels.
