Prevalence of Thyroid Dysfunction in XXXX : The Population-Based HUNT Study in Norway.

@entity1 @entity1375 @entity6 @entity12011 @entity1669 @entity1378 @entity164
CONTEXT: Associations between @entity12011 and @entity1669 are known but insufficiently characterized. Some evidence suggests that @entity164 2 @entity6 may also be associated with @entity1375 . OBJECTIVE: The objective of the study was to investigate associations of @entity12011 with the prevalence of hypo- and @entity1378 . DESIGN AND SETTING: This was a cross-sectional, population-based study of adults in two surveys of the Nord-Tr  ndelag Health (HUNT) Study. @entity1 : A total of 34 235 @entity1 of HUNT2 (1995-1997) and 48 809 @entity1 of HUNT3 (2006-2008) participated in the study. MAIN OUTCOME MEASURES: Prevalence of hypo- and @entity1378 was estimated, assessed by self-report, serum measurements, and linkage with the Norwegian Prescription Database. RESULTS: In HUNT2, @entity12011 was associated with a higher age-adjusted prevalence of @entity1375 among both @entity1 (prevalence ratio 1.79, 95% confidence interval [CI] 1.30-2.47) and @entity1 (prevalence ratio 2.71, 95% CI 1.76-4.19), compared with having no @entity6 . For @entity1378 , the corresponding cumulative prevalence ratios were 2.12 (95% CI 1.36-3.32) in @entity1 and 2.54 (95% CI 1.24-5.18) in @entity1 with @entity12011 . The age-adjusted excess prevalence of @entity1375 (   6 percentage points) and the presence of thyroid peroxidase antibodies (8-10 percentage points) associated with @entity12011 was similar in @entity1 and @entity1 . @entity164 2 @entity6 was not associated with the prevalence of @entity1375 . In HUNT3, associations were broadly similar to those in HUNT2. CONCLUSIONS: Autoimmune @entity6 , but not @entity164 2 @entity6 , was strongly and gender neutrally associated with an increased prevalence of hypo- and @entity1378 and the presence of thyroid peroxidase antibodies. Increased surveillance for @entity1375 appears not necessary in @entity1 with @entity164 2 @entity6 .
