XXXX chemical conversion coatings on metallic substrates for biomedical application: A review.

@entity174 @entity219 @entity8038 @entity1391 @entity460 @entity702 @entity68 @entity1760
Phosphate chemical conversion (PCC) technology has been investigated for improving the surface performance of metallic implants in the biomedical field over the last decade. The metallic materials, such as @entity1760 and its alloys, @entity702 , pure @entity68 and stainless steel are widely used as orthopedic devices for immobilization of @entity174 in clinic. They were previously studied as metal substrates for @entity8038 aiming to modify their biocompatibility and osteoconductivity. @entity219 , @entity460 and zinc-calcium PCC coatings are frequently utilized considering their nature and the end-use. Although @entity8038 has been confirmed to potentially improve the bio-performance of metallic implants in vitro and in vivo by many researchers, there are no unified standards or regulations to give quantitative appraisal of its quality and property. As such, an overview of several main @entity1391 phases together with their properties and behaviors in vitro and in vivo was conducted. The mechanism of phosphating was also briefly discussed. Critical qualities of @entity8038 used for biomedical application including corrosion resistance, wettability and bonding strength were analyzed separately. Biological response including in vitro cell investigations and in vivo tissue response were discussed in terms of the cytocompatibility and bioactivity of @entity8038 . Further investigations are proposed to develop appropriate performance evaluation measurements by combining conventional technologies and biomedical procedures.
