[Treatment of XXXX by efficient phototherapy].

@entity1 @entity4629 @entity4837 @entity648 @entity109 @entity3638 @entity413
@entity4837 derives from an initial insufficiency of all processes which metabolize hydrophobic @entity648 into diglucuronide excretable in bile. The term 'neonatal @entity3638 ' should only be used when there is a potential risk of @entity648 intoxication. Thus, the concept @entity3638 is not necessarily linked to the exceeding of a certain threshold value, but rather to the maturity of the @entity1 and its clinical condition. In this sense, @entity3638 is, therefore, always a syndrome requiring treatment. Besides substitution transfusion, which is highly effective per se, but risky and costly, enzyme induction (e.g., by administration of @entity109 ) represents an elegant causal therapy; however, because of its slow onset of action, it has to be given prophylactically to almost all newborns. In addition, this method requires a general induction of all microsomal enzyme systems, and is hence a major intervention in the process of maturation of the neonatal enzyme systems. Therefore, phototherapy must be regarded as the treatment of choice in cases of @entity4629 . It leads to a bypassing of the hepatic enzyme insufficiency in that by interaction between light with a wavelength of around 460 nm and the @entity648 molecules in the skin, an isomeric, water-soluble, renally secretable @entity648 is produced. The effect of phototherapy, i.e., the reduction in the serum @entity648 concentration under phototherapy, may be described as a simple e-function. The evaluation of this regular occurrence provides important information applicable to the phototherapy procedure: it should not be initiated prematurely, the duration of radiation should be as short as possible, the irradiated surface as large as possible, the radiation source should be exploited to a maximum by keeping the distance from the light source short and using lateral reflectors. As supporting measures intestinal lavage, early oral administration of @entity413 or oligosaccharide solution and possibly in some cases also @entity1 albumin are very useful.
