Expression of six XXXX major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver.

@entity19 @entity11005 @entity409 @entity72625
@entity19 major urinary proteins (MUPs) are encoded by a family of about 35 to 40 highly conserved genes. In the preceding paper (K. Shahan, M. Gilmartin, and E. Derman, Mol. Cell. Biol. 7:1938-1946, 1987), we presented the sequences of the most abundant @entity11005 mRNAs in the liver ( @entity11005 I, II, and III) and in the lachrymal ( @entity11005 IV) and submaxillary ( @entity72625 ) glands. We have shown that these five mRNAs are coded by five distinct genes, @entity11005 I through V. In the present communication, we examine the expression of @entity11005 genes in all of the six tissues in which @entity11005 mRNAs are synthesized, the mammary, parotid, @entity409 . We show that gene @entity11005 II is expressed in the liver and in the mammary gland, that gene @entity11005 IV is expressed in the lachrymal and parotid glands, and that gene @entity72625 is expressed in the submaxillary, sublingual, and lachrymal and parotid glands, and that gene @entity72625 is expressed in the submaxillary, sublingual, and lachrymal glands. Furthermore, we present evidence that in addition to genes @entity11005 I through V, another gene, @entity11005 VI, is expressed in BALB/c @entity19 in the parotid gland. The tissue-specific synthesis of @entity11005 mRNAs is thus brought about by two major mechanisms: the expression, in different tissues, of different members of the family and the expression of a single gene at various levels in different tissues. When a particular @entity11005 gene is expressed in several tissues, transcripts of this gene initiate at the same site and are spliced and polyadenylated in the same manner.
