Utero-ovarian ultrasonographic and Doppler flow analyses in female childhood XXXX survivors with regular menstruation and normal circulating follicle-stimulating hormone levels.

@entity5 @entity1
OBJECTIVE: To analyze the hormonal, ultrasonographic, and color Doppler parameters in a population-based follow-up study of female childhood @entity5 survivors with regular menstrual cycle and normal early follicular FSH values. DESIGN: Controlled, prospective clinical study. SETTING: University hospital. @entity1 (S): Twenty-eight female @entity1 affected by a @entity5 during childhood and 14 age-matched healthy controls. INTERVENTION(S): Hormonal, ultrasonographic, and color Doppler analyses. MAIN OUTCOME MEASURE(S): In the midluteal phase of the cycle, the @entity1 underwent hormonal assay of gonadotropins, E2, and P; ultrasonographic evaluation of the uterine and ovarian volume, the endometrial thickness, and of the corpus luteum characteristics; color Doppler analysis of uterine, intraovarian, and periluteal arteries. RESULT(S): A greater uterine volume and a better utero-ovarian vascularization was observed in controls in comparison with @entity5 survivors. In @entity1 who suffered from childhood @entity5 the P values were lower than in controls. On the basis of circulating P (> or < 20 nmol/L) values, we divided the former group in ovulatory and nonovulatory @entity1 . We observed that even if there were no differences between ovulatory @entity5 survivors and controls, the nonovulatory group showed a reduced uterine volume associated with elevated resistance at the level of uterine and intraovarian arteries. Among these two groups the time elapsed between the diagnosis of @entity5 and menarche was shorter in nonovulatory than in ovulatory @entity1 , and was directly correlated with both uterine volume (r = 0.660) and ovarian volume (r = 0.597). CONCLUSION(S): Ultrasonographic and Doppler analyses may noninvasively study the subtle utero-ovarian modification after anticancer therapies.
