@entity632 @entity137 changes myocardial energy metabolism in XXXX .

@entity632 @entity8 @entity137 @entity712 @entity35 @entity5 @entity1283 @entity299 @entity3105 @entity413
BACKGROUND: @entity632 ( @entity3105 ) is an antitumor antibiotics used against @entity5 . But its @entity137 limits the therapy of @entity3105 . OBJECTIVE: The purpose of this study was to evaluate @entity3105 @entity137 and the alteration of energy metabolism after short term and long term treatment. METHODS: Male @entity35 were randomly assigned to four groups: Short term control group, short term @entity3105 treatment group, long term control group and long term @entity3105 treatment group. In short term treated group, @entity35 were injected with @entity3105 i.p. at a dose of 2.5  mg/kg every 48  h for six equal injections. In long term, treated group, @entity35 were tail-intravenously injected with @entity3105 at a dose of 3  mg/kg once a week for four weeks. At the end of the experiment, histopathological changes, general blood biomarkers, endogenous antioxidant enzymes, cardiac energy metabolism and related mRNA expression of AMPK signal pathway were determined. RESULTS: @entity3105 induced prominent oxidative stress, a higher mortality rate, histological and ECG changes, obvious @entity1283 , @entity299 and @entity299 in short term treatment @entity35 . In long term treatment @entity35 , @entity3105 caused serious @entity8 and @entity299 , terrible @entity299 , clear alteration of substrate utilization and AMPK signal pathway. CONCLUSION: @entity3105 treatment can induce different damages after short term and long term treatment. In short term treatment group, @entity35 experienced a terrible mortality rate about 40%, the @entity299 , @entity299 and an early @entity712 which are potential connected with reduction of @entity413 utilization. In the long term treatment group, serious @entity8 and obvious changes of mRNA expressions of AMPK signal pathway were observed. Meanwhile, the serious @entity299 and substrate utilization alteration denote an obviously @entity712 . This study could be helpful to develop therapy strategies of @entity3105 complications for clinical application.
