Bioavailability of @entity65803 in XXXX after liver enzyme induction by various inducers with or without protein binding properties.

@entity3175 @entity35 @entity11464 @entity2644 @entity109 @entity3174 @entity41379 @entity869 @entity65803
The serum levels and the half life of @entity869 derived from @entity65803 after administration of the latter to a total of 61 @entity35 classified in 7 groups were determined. Each of these groups was pre-treated for 15 days with the following inducers; @entity109 , @entity3174 , @entity3175 , @entity2644 and @entity11464 . The control group received saline. The @entity41379 concentration in the urine prior to and after the administration of inducers and the liver weight were taken as enzyme induction indices. Results showed a positive correlation between the indices of induction and the levels of @entity869 originating from @entity65803 with a significant correlation coefficient between the serum levels of @entity869 and urine @entity41379 for all drugs studied. The different effect of the various drugs indicated that they could be classified into the following two groups: a) those that induced a significant increase of the levels and half life (t1/2) of @entity869 . The effect was significant in decreasing order for @entity11464 (r = 0,990), @entity3175 (r = 0,990) and @entity3174 (r = 0,753). b) those which initially resulted in a significant increase of the levels of @entity869 and thereafter in a decrease with a significant shortening of its t1/2 too. The effect was most significant for @entity109 (r = 0,887) and less so for @entity2644 (r = 0,800). Only for these two drugs was a significant and actually negative correlation observed between @entity41379 and t1/2 that is: @entity109 (r = -0,967) @entity2644 (r = -0,752). Results suggest an interaction of @entity65803 and the above inducers.
