Role of @entity56013 XXXX to mediastinal lymph nodes in @entity1149 .

@entity1 @entity56013 @entity5 @entity1149 @entity477 @entity3
BACKGROUND: @entity56013 @entity3 to mediastinal lymph nodes is a well-known phenomenon in @entity1149 ( @entity1149 ). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected @entity1149 with either @entity56013 @entity3 or continuous mediastinal lymph node @entity3 (N2). @entity1 AND METHODS: We analyzed retrospectively the data of 45 @entity1 with a @entity477 -stage, who underwent resection for @entity1149 . Seventeen of these @entity1 (37.8%), showing no metastatic involvement of hilar (N1) lymph nodes, were compared to the remaining 28 @entity1 with infiltration of hilar nodes (N1) as well as N2 nodes. RESULTS: Multivariate analysis showed no statistically significant difference between the @entity56013 @entity3 and the continuous N2 group regarding sex, age, histology, T- or M-status. The frequency of @entity56013 @entity3 was higher in @entity1 with a @entity5 in the upper lobe (n = 12, 71%) compared to the lower lobe (n = 5, 29%). This difference was not statistically significant. In @entity1 with a non-continuous lymph node spread, 29 out of 119 resected mediastinal lymph nodes were infiltrated (1.7 per @entity1 , range: 1-10). Compared to 83 metastatic involved lymph nodes out of 198 resected mediastinal nodes (three per @entity1 , range: 1-10) in @entity1 with involvement of N1 and N2 nodes (P = 0.034, Mann-Whitney test). The 5-year survival rate of @entity477 @entity1 with @entity56013 @entity3 was 41% compared to 14% in @entity1 with involvement of N1 and N2 nodes (P = 0.019). CONCLUSIONS: @entity477 @entity1 with mediastinal lymph node @entity56013 @entity3 have a more favorable prognosis compared to @entity477 @entity1 with continuous infiltration of the regional lymph nodes. @entity1 with a continuous lymph node involvement show an increased number of infiltrated mediastinal lymph nodes per @entity1 compared to @entity1 with a non-continuous spread. @entity56013 @entity3 is an independent prognostic factor of survival. The presence of @entity56013 @entity3 seems to be a unique subgroup of @entity477 disease in @entity1149 .
