The XXXX @entity2289 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population.

@entity1 @entity1187 @entity2289 @entity101 @entity2299 @entity71312
Background. @entity1187 ( @entity1187 ) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. @entity2289 ( @entity2289 ) is the major inhibitor of the fibrinolysis and also is part of immune response. The @entity71312 gene polymorphism is related to increased @entity2289 protein levels. The aim of the study is to evaluate the association of @entity71312 @entity2289 polymorphism with @entity1187 . Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 @entity1 with diagnosis of @entity1187 . Results. The most important risk factor in our population was @entity101 , followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with @entity1187 . The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of @entity1187 dyslipidemic @entity1 (OR = 1.99, P = 0.04). The A allele and AA genotype of -844 polymorphism of @entity2289 gene are risk factors for @entity1187 . The AA genotype might be associated with the development of @entity2299 in @entity1187 @entity1 .
