@entity2493 attenuates the mitochondrial translocation of mitochondrial fission proteins and @entity589 , cytosolic @entity460 overload and cell death in XXXX -induced @entity137 in @entity521 SH-SY5Y cells.

@entity24893 @entity137 @entity589 @entity7865 @entity888 @entity75 @entity71777 @entity2493 @entity460 @entity521
UNASSIGNED: @entity888 ( @entity7865 ) is an addictive drug that can cause @entity137 and @entity75 . Several pieces of evidence have demonstrated that @entity7865 @entity137 results in increases in oxidative stress that regulate an intracellular signaling cascade that leads to cell death. Recently, several studies have emphasized that the overload of cytosolic @entity460 levels and mitochondrial fission into a small mitochondrial structure is involved in cell death processes. In the present study, we aimed to investigate the effects of @entity7865 @entity137 on cytosolic @entity460 overload and mitochondrial fission in @entity521 SH-SY5Y cells. Additionally, the protective effect of @entity2493 against @entity7865 -induced @entity137 was also investigated. The results of the present study demonstrated that @entity7865 significantly decreases cell viability and increases the levels of mitochondrial fission ( @entity71777 and @entity24893 ) proteins and pro-apoptotic protein, @entity589 in isolated mitochondria. The levels of @entity24893 in the cytosol of @entity7865 -treated cells had no significant differences compared to the control untreated cells. @entity7865 also significantly increased the cytosolic @entity460 levels. @entity2493 reversed the toxic effects of @entity7865 by restoring cell viability and inhibiting the increase in mitochondrial @entity71777 levels and the mitochondrial translocation of @entity24893 and @entity589 . Additionally, @entity2493 was able to reduce the @entity7865 -induced increase in cytosolic @entity460 levels and fragmented mitochondria into small globular structures in SH-SY5Y cells. The results of the present study demonstrate the potential abilities of @entity2493 to maintain the homeostasis of mitochondrial dynamics and cytosolic @entity460 levels in @entity7865 -induced @entity137 in neuronal cells.
