Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts XXXX in adolescence.

@entity1 @entity2023 @entity16292 @entity7671 @entity3991
BACKGROUND: Component-resolved diagnosis might improve the prediction of future allergy in young @entity1 . OBJECTIVE: We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and @entity2023 to birch pollen (ARbp) from early childhood up to age 16 years. METHOD: Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/ @entity1 Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 @entity1 were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. RESULTS: IgE reactivity to @entity3991 v 1 was found in 12%, 17%, and 25% of @entity1 at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: @entity3991 v 1  > @entity7671 d 1  > Cor a 1.04  > Ara h 8  > Pru p 1  > @entity16292 g 1  > Api g 1  > Act d 8  > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of @entity3991 v 1-specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. @entity1 with severe ARbp at age 16 years had higher levels of @entity3991 v 1-specific IgE at age 4 years compared with @entity1 with mild symptoms. CONCLUSION: ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.
