Asynchrony in executive networks predicts XXXX in @entity15 .

@entity1 @entity73 @entity15
OBJECTIVE: Cognitive slowing is a core neuropsychological symptom of @entity15 ( @entity15 ). We aimed to assess the extent to which @entity73 in @entity15 was predicted by changes in dorsolateral prefrontal networks. METHOD: We assessed @entity1 with relapsing-remitting @entity15 and healthy controls (HCs) on measures of processing speed. @entity1 underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. RESULTS: @entity1 were slower than HCs on the processing speed tasks. @entity1 showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. @entity1 ' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, @entity1 who had stronger functional connections with DLPFC in group-disparate networks performed faster than @entity1 with weaker connections with DLPFC in group-disparate networks. CONCLUSION: Results suggest that @entity15 -related @entity73 can be accounted for by systemic alterations in executive functional networks. (PsycINFO Database Record
