The role of the @entity3449 -angiotensin system in XXXX affecting the systemic and cerebral circulations.

@entity1 @entity64 @entity101 @entity75 @entity1317 @entity3449 @entity299 @entity35 @entity385
@entity101 is a rare but serious syndrome complicating 1% of essential @entity101 and causing @entity299 . Despite improved anti- @entity101 medication, the incidence of this condition fails to decline. In the first part of this review, we discuss transgenic @entity35 models of @entity101 , generated by over-expressing @entity3449 , to illustrate the role of the @entity3449 -angiotensin system in the development of @entity101 and @entity101 . In the second part, we focus on the cerebrovascular response to @entity101 and discuss new data using a conditional, transgenic model of @entity101 , the inducible @entity101 @entity35 (IHR). @entity385 associates strongly with @entity101 in @entity1 and the mechanisms by which @entity101 predisposes to different types of @entity64 remains poorly understood. @entity35 have similar cerebrovascular anatomy and structure to @entity1 and as such provide a good experimental tool. To date, such models lack controllability and blood-pressure matched controls. Using the IHR, we have manipulated dietary salt and water intake to generate a novel, controllable @entity64 phenotype. @entity101 develops over a predictable time period, permitting the study of developing @entity75 . @entity1317 and @entity101 are not affected. Dissociation of the systemic and central vascular responses in this way, will allow for comparative study of animals with equivalent @entity101 , genetic background and systemic features of @entity101 with or without @entity64 .
