The Mitochondria in XXXX : From Pathogenesis to Therapeutic Promise.

@entity1 @entity32 @entity712 @entity101 @entity6 @entity63 @entity13088 @entity340 @entity2383
SIGNIFICANCE: @entity6 is an important risk factor for the development of @entity712 ( @entity712 ). Given the increasing prevalence of @entity6 in the population, strategies are needed to reduce the burden of @entity712 in these @entity1 . Recent Advances: @entity6 is associated with several pathologic findings in the heart including dysregulated metabolism, lipid accumulation, oxidative stress, and @entity32 . Emerging evidence suggests that @entity2383 may be a central mediator of these pathologic responses. The development of therapeutic approaches targeting mitochondrial biology holds promise for the management of @entity712 in @entity6 @entity1 . CRITICAL ISSUES: Despite significant data implicating mitochondrial pathology in @entity13088 , the optimal pharmacologic approach to improve mitochondrial function remains undefined. FUTURE DIRECTIONS: Detailed mechanistic studies coupled with more robust clinical phenotyping will be necessary to develop novel approaches to improve cardiac function in @entity6 . Moreover, understanding the interplay between @entity6 and other cardiac stressors ( @entity101 , @entity63 , and @entity340 ) will be of the utmost importance for clinical translation of scientific discoveries made in this field. Antioxid. Redox Signal. 22, 1515-1526.
