Comparative proteomics and global genome-wide expression data implicate role of XXXX in lung cancer.

@entity2220 @entity5 @entity36435 @entity71828 @entity420 @entity7391
BACKGROUND: @entity5 loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating @entity5 -associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards. MATERIALS AND METHODS: In this study, 2DE proteomic profiles were examined from lysates of 13 lung- @entity420 tissue samples and matched against the A549 cell line proteome. A549 matched- @entity5 -specific hits were analyzed and characterized by MALDI-TOF/MS. RESULTS: Comparative analysis identified a total of 13 protein spots with differential expression. These proteins were found to be involved in critical cellular functions regulating @entity7391 metabolism, @entity36435 pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only a single non-predictive protein spot was found to be a @entity5 cell specific hit, identified as @entity71828 ( @entity71828 ). Pathway reconstruction studies showed that @entity71828 lies at the centre of @entity5 metabolic pathways. CONCLUSIONS: The findings in this report are suggestive of a regulatory role of @entity71828 in control of proliferation and @entity2220 .
