Degree of corticospinal tract damage correlates with motor function after XXXX .

@entity1 @entity73 @entity64 @entity385
OBJECTIVES: Direct injury to the corticospinal tract (CST) is a major factor defining @entity73 after @entity64 . Diffusion tensor imaging (DTI) tractography allows definition of the CST. We sought to determine whether DTI-based assessment of the degree of CST damage correlates with @entity73 at each phase of @entity385 . METHODS: We evaluated @entity1 at the acute (3-7 days), subacute (30 days), and chronic (90 days) phases of @entity385 with DTI and clinical motor scores (upper extremity Fugl-Myer test [UE-FM], motor items of the National Institutes of Health @entity64 Scale [mNIHSS]). The CST was identified and virtual fiber numbers (FN) were calculated for the affected and contralateral CST. We used Spearman correlation to study the relationship of FN ratio (FNr) (affected/unaffected CST) with motor scores at each time point, and the regression model to study the association of the acute parameters with chronic motor scores. RESULTS: We studied 23 @entity1 . Mean age was 66.7 (  12) years. FNr correlated with UE-FM score in the acute (r = 0.50, P = 0.032), subacute (r = 0.57, P = 0.007), and chronic (r = 0.67, P = 0.0008) phase, and with mNIHSS in the acute (r = -0.48, P = 0.043), subacute (r = -0.58, P = 0.006), and chronic (r = -0.75, P = 0.0001) phase. The combination of acute NIHSS and FNr significantly predicted chronic UE-FM score (r = 0.74, P = 0.0001). INTERPRETATION: DTI-defined degree of CST injury correlates with @entity73 at each phase of @entity385 . The combination of baseline FNr and NIHSS predicts motor outcome. DTI-derived CST assessment could become a surrogate marker of @entity73 in the design of neurorestorative clinical trials.
