[Association between biochemical markers and @entity1002 in the ST-elevation acute XXXX .]

@entity1 @entity908 @entity583 @entity67 @entity413 @entity1002
OBJECTIVE: The association between biochemical markers and left ventricular ejection fraction in @entity1 with @entity583 was not completely studied. Our goal is to study the association between biochemical markers and @entity1002 in @entity1 with ST-elevation acute @entity583 . METHODS: With an observational and prospective design we included @entity1 with less than 24h ST-elevation @entity583 . Leukocytes, @entity413 , B-type natriuretic peptide and T troponin were measured at admission, and @entity908 -phosphokinase and @entity908 -phosphokinase-MB were measured at admission and serially, and correlated with the ejection fraction estimated by echocardiography. RESULTS: A total of 108 @entity1 were included. The median left ventricular ejection fraction was 48% (interquartile range 41-57). Simple linear regression analysis showed that B-type natriuretic peptide (P=.005), peak @entity908 -phosphokinase-MB (P=.01), leukocyte count (P=.001) and @entity413 (P=.033) were inversely and significantly associated with the left ventricular ejection fraction. The other parameters showed no association. B-type natriuretic peptide (P=.01) and peak @entity908 -phosphokinase-MB (P=.02) were the only two variables significantly associated with the left ventricular ejection fraction in the multiple linear regression analysis. Both markers were significantly associated with a left ventricular ejection fraction < 50%, independently of other clinical variables. CONCLUSION: B-type natriuretic peptide and peak @entity908 -phosphokinase-MB showed significant association with left ventricular ejection fraction in the acute phase of ST elevation acute @entity583 . This association was independent of the presence of other biochemical markers and clinical variables related to @entity67 .
