Relationship of XXXX intolerance to serum lipoprotein profiles in childhood. The Bogalusa Heart Study.

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Three hundred-eighty-eight @entity1 were selected from a total community and biracial (black-white) population for a special in-depth study related to serum lipoproteins and @entity1735 metabolism. Based on two previous serum lipoprotein determinations of high and/or low beta and pre-beta-lipoprotein @entity165 , they were stratified into four groups. A @entity413 tolerance test was performed for fasting, 30-minute, and one-hour @entity413 , insulin, free @entity1718 , @entity460 , and @entity1760 . Observations of height, weight, and triceps skinfold were also obtained on the @entity1 . @entity1 in the high beta-lipoprotein @entity165 groups tended to have higher @entity413 levels and were more @entity28 than the other groups, while @entity1 in the high pre-beta-lipoprotein @entity165 group tended to have high insulin levels following the @entity413 load. Fasting blood levels were not appreciably different in the various groups, but after the @entity413 load an unusually high insulin secretory response occurred in black @entity1 , especially black @entity1 . Black @entity1 also demonstrated somewhat lower blood @entity3363 than the other race-sex groups. The insulin/ @entity413 ratios were dramatically different in the black @entity1 , especially black @entity1 . These differences were particularly noted in the groups with the high pre-beta-lipoprotein. Black @entity1 also tended to have higher insulin/free @entity844 ratios during the @entity413 tolerance test. These differences persisted even after adjusting for @entity28 . Although not significant, @entity460 levels consistently decreased in all groups following a @entity413 load. The observation of racial contrasts in @entity413 and insulin responses are interesting. While black @entity1 appear to show low @entity413 and high insulin responses to a @entity413 load, low and delayed insulin response along with high @entity413 response occur in whites, especially white @entity1 . Since white @entity1 have greater body fat content, these observations suggest more insulin resistance in white @entity1 . Even at low levels of @entity28 , subtle @entity1735 lipid metabolic aberrations are found in @entity1 having high levels of serum lipoproteins. A persistence of these conditions could contribute to accelerated @entity731 and subsequent @entity453 .
