Response of Kampuchean strains of @entity3964 falciparum to antimalarials: in-vivo assessment of XXXX and @entity4807 plus @entity803 ; multiple drug resistance in vitro.

@entity1 @entity281 @entity8775 @entity4807 @entity9231 @entity3964 @entity503 @entity803 @entity221
Forty-three @entity1 were enlisted in the in-vivo test for sensitivity of Kampuchean strains of @entity3964 to @entity4807 . The mean parasite density count on day 0 was 32,398 asexual parasites per microliter of blood. With a dosage of 1.5 g @entity4807 base daily for 10 days the average parasite clearance time was 5.6 days, and the average duration of @entity221 3.4 days. The in-vivo test was evaluated at 7 and 10 days after the start of therapy. After 7 days only 16 @entity1 were parasite negative by microscopic examination (S); 20 @entity1 had an RI recrudescence, four @entity1 responded at the RII level and three at the RIII level. Evaluating the in-vivo test at 10 days, the number of @entity1 parasite negative increased to 18, the number of those with an RI level of resistance increased to 21, two @entity1 gave an RII response and two had an RIII level of resistance. Twenty-two adult males were included in an in-vivo test of the sensitivity of @entity3964 to @entity4807 plus @entity803 . The course of treatment was: @entity4807 3 x 500 mg daily for 10 days, @entity803 3 x 500 mg for 7 days. Parasite density counts on day 0 averaged 11,393 asexual parasites per microliter of blood. The average parasite clearance time was 5.9 days, and the average duration of @entity221 was 3.8 days. After 7 days of treatment, 81.8% of @entity1 were parasite negative, while one @entity1 had a recrudescence after 17 days (RI). Three @entity281 were resistant at the RII level. By prolongation of the observations to day 10, the parasitaemia was cleared in all @entity1 , i.e. all @entity281 were sensitive to @entity4807 plus @entity803 . Thirty-four @entity1 with @entity9231 were screened for in-vitro resistance to @entity503 , @entity8775 and @entity4807 using the WHO standard micro-test.(ABSTRACT TRUNCATED AT 250 WORDS)
