Podocyte Injury-Driven Lipid Peroxidation Accelerates the Infiltration of Glomerular Foam Cells in XXXX .

@entity632 @entity1748 @entity8 @entity1 @entity753 @entity1007 @entity6579 @entity19 @entity628
UNASSIGNED: Intracapillary foam cell infiltration with podocyte alterations is a characteristic pathology of @entity628 ( @entity628 ). We investigated the possible role of podocyte injury in glomerular macrophage and foam cell infiltration in a podocyte-selective injury model (NEP25 @entity19 ) and @entity753 model [ @entity1748 deficiency ( @entity1748 (-/-)) @entity19 ] with @entity632 -induced @entity8 . Acute podocyte selective injury alone failed to induce glomerular macrophages in the NEP25 @entity19 . However, in the @entity632 -treated @entity753 @entity1748 (-/-) @entity19 , glomerular macrophages/foam cells significantly increased and were accompanied by lipid deposition and the formation and ingestion of oxidized phospholipids (oxPLs). Glomerular macrophages significantly correlated with the amount of glomerular oxPL. The NEP25/ @entity1748 (-/-) @entity19 exhibited severe @entity1007 , glomerular lipid deposition, and @entity8 . Imaging mass spectrometry revealed that a major component of oxidized low-density lipoprotein, @entity6579 16:0 and 18:0, was present only in the glomeruli of NEP25/ @entity1748 (-/-) @entity19 . @entity6579 16:0 stimulated mesangial cells and macrophages, and @entity6579 18:0 stimulated glomerular endothelial cells to express adhesion molecules and chemokines, promoting macrophage adhesion and migration in  vitro. In @entity1 @entity628 , glomerular macrophage-derived foam cells contained oxPLs accompanied by the expression of chemokines in the tuft. In  conclusion, glomerular lipid modification represents a novel pathology by podocyte injury, promoting @entity628 . Podocyte injury-driven @entity6579 de novo accelerated glomerular macrophage-derived foam cell infiltration via @entity6579 -mediated expression of adhesion molecules and chemokines in  glomerular resident cells.
