Antitumor activity of XXXX extract from roots of Agrimonia pilosa Ledeb.

@entity137 @entity1042 @entity5 @entity19 @entity786 @entity189 @entity16532 @entity1492 @entity665
To evaluate the antitumor activity of Agrimonia pilosa LEDEB., the effects of the @entity1042 extract from roots of the plant ( @entity16532 ) on several transplantable rodent @entity5 were investigated. @entity16532 significantly prolonged the life span of S180-, Meth-A @entity1492 - and MM-2 mammary @entity189 -bearing @entity19 by intraperitoneal (i.p.) pre- or postmedication. @entity16532 also inhibited the growth of S-180 solid @entity5 . On the other hand, the prolongation of life span induced by @entity16532 on S-180 ascites @entity5 -bearing @entity19 was markedly minimized or abolished by the pretreatment of @entity786 . @entity16532 showed considerably strong @entity137 on MM-2 cells in vitro, but the effect was diminished to one-tenth by the addition of serum to the culture. Against the host animals, the peripheral white blood cells in @entity19 were significantly increased from 2 to 5 days after the i.p. injection of @entity16532 . On 4th day after the injection of @entity16532 , the peritoneal exudate cells which possessed the cytotoxic activity on MM-2 cells in vitro were also increased to about 5-fold those in the non-treated control. The spleen of the @entity19 was enlarged, and the spleen cells possessed the capacity to uptake @entity665 . However, @entity16532 did not show direct migration activity like other mitogens against spleen cells from non-treated @entity19 . These results indicate that the roots of Agrimonia pilosa contain some antitumor constituents, and possible mechanisms of the antitumor activity may be some host-mediated actions and direct @entity137 .
