Effects of a high-protein diet versus dietary supplementation with XXXX on @entity5706 crystal formation in urine of clinically normal @entity468 .

@entity8777 @entity5836 @entity2827 @entity1219 @entity5828 @entity5706 @entity5819 @entity468
OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity5819 ( @entity8777 ) on @entity5706 crystal formation in the urine of clinically normal @entity468 by measuring the urine concentration of @entity5836 ( @entity5828 )-insoluble sediment, urine pH, @entity5706 activity product (SAP), number of @entity5706 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity468 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5828 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity468 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2827 ( @entity1219 ) or @entity8777 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5828 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity8777 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity5706 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5828 -insoluble sediment containing THP (study 2), in contrast to the @entity8777 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5828 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity8777 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity5706 crystal formation in clinically normal @entity468 .
