The role of adenovirus 36 as a risk factor in XXXX : The first clinical study made in the fatty tissues of adults in Turkey.

@entity1 @entity9504 @entity28 @entity412 @entity165
UNASSIGNED: Obesity which developes due to multifactorial reasons, was associated recently with @entity1 @entity9504 ( @entity9504 ). The aim of this study was to investigate the prevalence of @entity9504 antibodies in @entity28 adults and also to investigate the DNA of @entity9504 in their adipose tissue. In this cross-sectional and case-control based study, 49 @entity28 adults, with BMI >= 30  kg/m(2), and 49 non- @entity28 adults, with BMI  <=25  kg/m(2), applied for esthetic purposes and were included in this study as @entity1 and control groups, respectively. Adipose tissue samples, obtained by the lipoaspiration method, were studied by single-step PCR and nested-PCR methods. Simultaneously, the presence of @entity9504 antibodies and serum leptin and adiponectin levels were assessed by serum neutralization assay (SNA) and ELISA, respectively. Serum samples which didn't cause a cytopathic effect at >= 1:8 were accepted as positive. @entity9504 antibody was detected in 6 (12.2%) of 49 @entity1 by SNA and was statistically significant (p  <  0.05). @entity9504 DNA was not detected in any of the adipose tissue samples of the @entity1 or control groups. Mean BMI and leptin levels were higher in the @entity9504 -positive group, while adiponectin levels were found to be lower in the @entity9504 -positive group. Although no statistically significant difference was found in @entity165 and @entity412 levels between the two groups (p  >  0.05), lower mean serum @entity165 and @entity412 levels were found in the @entity9504 -positive @entity1 . In conclusion, we couldn't detect @entity9504 DNA in adipose tissue; however, we detected significantly higher @entity9504 antibody levels in the @entity28 group compared to the non- @entity28 group, according to the both univariant and multivariant analyses, suggesting that @entity9504 may play a role in @entity28 . There is a need for new and extended serial, particularly cohort and @entity1 -based, studies in order to have a clear understanding of the @entity9504 relationship.
