Dissecting @entity1028 in Ang II-infused XXXX : Suprarenal Branch Ruptures and Apparent Luminal Dilatation.

@entity1 @entity19 @entity2178 @entity439 @entity1410 @entity397 @entity1028
AIMS: In this work we provide novel insight into the morphology of dissecting @entity1028 in @entity2178 -infused @entity19 . We demonstrate why they exhibit a large variation in shape and, unlike their @entity1 counterparts, are located suprarenally rather than infrarenally. METHODS AND RESULTS: We combined synchrotron-based ultra-high resolution ex vivo imaging (phase contrast X-Ray tomographic microscopy) with in vivo imaging (high-frequency ultrasound and contrast-enhanced micro-CT) and image-guided histology. In all @entity19 we observed a tear in the tunica media of the abdominal aorta near the ostium of the celiac artery. Independently we found that, unlike the gradual luminal expansion typical for @entity1 @entity439 , the outer diameter increase of @entity2178 -induced dissecting @entity439 in @entity19 was related to one or several intramural @entity1410 . These were caused by @entity397 media near the ostium of small suprarenal side branches, which had never been detected by the established small-animal imaging techniques. The tear near the celiac artery led to apparent luminal dilatation, while the intramural @entity1410 led to a dissection of the tunica adventitia on the left suprarenal side of the aorta. The number of @entity397 branches was higher in those @entity439 that extended into the thoracic aorta, which explained the observed variability in @entity439 shape. CONCLUSIONS: Our results are the first to describe apparent luminal dilatation, suprarenal @entity397 and intramural @entity1410 formation in dissecting @entity1028 in @entity19 . Moreover we validate and demonstrate the vast potential of phase contrast X-Ray tomographic microscopy in cardiovascular small animal applications.
