Proinflammatory effects of oxidative stress in XXXX : role of additional angiotensin II blockade.

@entity1 @entity32 @entity644 @entity8 @entity6 @entity740 @entity9886 @entity2842 @entity1234 @entity1011 @entity631 @entity6738 @entity1865
Oxidative stress plays an important role in causing progressive @entity740 ( @entity740 ). We examined the influence of add-on ANG II receptor blockade administered as @entity9886 (50 mg/day for 1 mo) on oxidative stress and proinflammatory state of the kidney in @entity1 with @entity740 . All subjects were taking an angiotensin-converting enzyme inhibitor plus other antihypertensive agents. Oxidative stress to lipids and proteins was measured by an HPLC assay for @entity1234 ( @entity1865 ) and @entity6738 concentration, respectively. Urinary @entity32 was measured by @entity2842 ( @entity2842 ) excretion rate. The etiology of @entity740 was @entity6 in 12 and @entity631 in 4 @entity1 . There was no change in @entity644 or 24-h ambulatory blood pressure (BP) with add-on ANG II receptor blockade with @entity9886 therapy. Before @entity9886 therapy, urinary protein and albumin oxidation were 99 and 71% higher, respectively, compared with in plasma (P < 0.05). There was a 35% reduction in urinary oxidized albumin with add-on @entity9886 therapy (P = 0.036). Urinary and plasma @entity1865 were elevated compared with age-matched controls. Urinary @entity1865 was significantly reduced from 4.75 +/- 3.23 to 3.39 +/- 2.17 micromol/g @entity1011 with add-on @entity9886 therapy. However, plasma @entity1865 or oxidized proteins did not change in response to additional ANG II blockade. A good correlation was seen between the change in urinary oxidized albumin and @entity2842 levels (r = 0.61, P = 0.012). These data demonstrate that oxidative damage to urinary protein and lipids can be reduced with additional ANG II receptor blockade, independently of reductions in @entity644 or BP. Urinary measurements of markers of oxidative damage to lipids and proteins appear to be more sensitive than plasma measurements in @entity1 with @entity740 . The significant association of the change in urinary @entity2842 with a reduction in oxidative stress supports the role of the redox state in the kidney with @entity8 .
