@entity12698 enhances radiation response of secondary XXXX of a @entity1 @entity1149 via antiangiogenesis in vivo.

@entity1 @entity12698 @entity3478 @entity5 @entity19 @entity1149 @entity189 @entity915 @entity3 @entity3840
PURPOSE: @entity3840 ( @entity3840 ) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhance the response of @entity5 to radiation. Radiosensitizing effects of @entity3840 inhibition have not been reported for bone @entity3 . Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective @entity3840 inhibitor @entity12698 in secondary @entity3478 of a @entity1149 in vivo. MATERIALS AND METHODS: @entity1 A549 lung @entity189 were implanted into a cranial window preparation in male @entity915 @entity19 (n = 24). Animals were treated with either @entity12698 or radiation (7 Gy single photon dose) alone or a combination of @entity12698 and radiation, respectively. Untreated animals served as controls. The impact of radiation and @entity3840 inhibition on angiogenesis, microcirculation, and @entity5 growth was analyzed over 28 days by means of intravital microscopy and histological methods. RESULTS: Monotherapies with radiation as well as @entity12698 had significant antitumor effects compared to untreated controls. Both therapies reduced @entity5 growth and vascularization to a similar extent. The simultaneous administration of @entity12698 and radiation further enhanced the antitumor and antiangiogenic effects of single-beam radiation. With the combined treatment approach, @entity5 vascularization and @entity5 size were decreased by 57% and 51%, respectively, as compared to monotherapy with radiation. CONCLUSION: The combined application of radiation therapy and @entity3840 inhibition showed synergistic effects concerning the inhibition of @entity5 growth and @entity5 angiogenesis. Therefore, the combination of radiation with @entity3840 inhibitor therapy represents a promising approach to improve the therapeutic efficacy of radiotherapy of bone @entity3 .
