Adjuvant radiotherapy in XXXX of the uterine cervix -The prognostic role of hemoglobin levels.

@entity1 @entity189 @entity417
UNASSIGNED: 5113 Background: @entity417 was found to be an adverse prognostic factor and associated with poorer response to treatment and decreased survival in @entity1 undergoing primary radiotherapy or radiochemotherapy for advanced @entity189 of the uterine cervix. This study was to determine the influence of @entity417 in the postoperative adjuvant treatment situation. METHODS: By chart review a collective of 183 @entity1 who received adjuvant radiotherapy because of risk factors after radical surgery (n=109) or inadequate surgery (simple hysterectomy; n=74) were selected. Hemoglobin levels, measured prior to and during adjuvant radiotherapy were analyzed in relation to local control, disease-free and overall survival using Kaplan-Meier analyses and Cox regression analyses. RESULTS: Hemoglobin levels prior to radiotherapy proved to have significant influence on overall (OS) and recurrence-free survival in the entire collective (OS - Log Rank all @entity1 = 7.5; df = 1; p = 0.006). However, analyses of subgroups with risk factors after radical surgery and inadequate surgery show that the observed difference is mainly due to the second group (OS - Log Rank inadequate surgery = 10.8; df = 1; p = 0.001; DFS- Log rankinadequate surgery = 11.6; df = 1; p < 0.001). Multifactorial analyses using Cox regression analyses confirmed the value of hemoglobin levels in comparison with stage and grading. Local control in the named subgroup was also significantly improved. CONCLUSIONS: Normal hemoglobin levels (> 11g/dL) prior to and during adjuvant radiotherapy for @entity189 of the uterine cervix seem to be important especially when @entity1 are treated because of inadvertent simple hysterectomy. No significant financial relationships to disclose.
