Challenges of @entity6 prevention in the real world: results and lessons from the XXXX .

@entity1 @entity6 @entity164 @entity10281 @entity65
OBJECTIVE: To assess effectiveness and implementability of the public health programme Life! Taking action on @entity6 in Australian @entity1 at risk of developing @entity164 2 @entity6 . RESEARCH DESIGN AND METHODS: @entity6 ( @entity6 ) was a unique study assessing effectiveness of Life! that used a randomized controlled trial design. Intervention @entity1 with AUSDRISK score >= 15 received 1 individual and 5 structured 90   min group sessions. Controls received usual care. Outcome measures were obtained for all @entity1 at baseline and 12   months and, additionally, for intervention @entity1 at 3   months. @entity10281 ( @entity10281 ) and intention to treat (ITT) analyses were performed. RESULTS: @entity10281 analyses were considered more informative from our study. In @entity10281 analyses, intervention @entity1 significantly improved in weight (-1.13   kg, p=0.016), waist circumference (-1.35   cm, p=0.044), systolic (-5.2   mm   Hg, p=0.028) and diastolic blood pressure (-3.2   mm   Hg, p=0.030) compared with controls. Based on observed weight change, estimated risk of developing @entity6 reduced by 9.6% in the intervention and increased by 3.3% in control @entity1 . Absolute 5-year @entity65 ( @entity65 ) risk reduced significantly for intervention @entity1 by 0.97 percentage points from 9.35% (10.4% relative risk reduction). In control @entity1 , the risk increased by 0.11 percentage points (1.3% relative risk increase). The net effect for the change in @entity65 risk was -1.08 percentage points of absolute risk (p=0.013). CONCLUSIONS: @entity6 effectively reduced the risk of @entity6 and @entity65 , but the intervention effect on weight and waist reduction was modest due to the challenges in recruiting high-risk individuals and the abbreviated intervention.
