@entity130 Exposure and @entity1005 Symptoms Predict Onset of Cardiovascular Events in XXXX .

@entity1 @entity64 @entity146 @entity1005 @entity583 @entity65 @entity130
BACKGROUND: -Psychological stress is a proposed risk factor for @entity65 ( @entity65 ), and @entity1005 ( @entity1005 ), the sentinel stress-related @entity146 , occurs twice as frequently in @entity1 as @entity1 . However, whether @entity1005 contributes to @entity65 risk in @entity1 is not established. METHODS AND RESULTS: -We examined @entity130 exposure and @entity1005 symptoms in relation to incident @entity65 over a 20-year period in 49,978 @entity1 in the Nurses' Health Study II. Proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity65 events confirmed by additional information or medical record review [n=548, including @entity583 (n=277) and @entity64 (n=271)]. @entity130 exposure and @entity1005 symptoms were assessed using the Brief @entity130 Questionnaire and a @entity1005 screen. Compared to no @entity130 exposure, endorsing 4 or more @entity1005 symptoms was associated with increased @entity65 risk after adjusting for age, family history, and childhood factors (HR=1.60 [95% CI, 1.20-2.13]). Being @entity130 -exposed and endorsing no @entity1005 symptoms was associated with elevated @entity65 risk (HR=1.45 [95% CI, 1.15-1.83]), although being @entity130 -exposed and endorsing 1-3 @entity1005 symptoms was not. After adjusting for adult health behaviors and medical risk factors, this pattern of findings was maintained. Health behaviors and medical risk factors accounted for 14% of the @entity130 /no symptoms- @entity65 association and 47% of the @entity130 /4+ symptoms- @entity65 association. CONCLUSIONS: - @entity130 exposure and elevated @entity1005 symptoms may increase risk of @entity65 in this population of @entity1 . These findings suggest screening for @entity65 risk and reducing health risk behaviors in @entity130 -exposed @entity1 may be promising avenues for prevention and intervention.
