Beneficial effect of XXXX therapy on stooped posture in Parkinson's disease.

@entity1 @entity1726 @entity3034 @entity935
OBJECTIVE: This study was designated to quantitatively evaluate the effect of @entity3034 on spinal posture in @entity1 with @entity1726 using a computer-assisted handheld SpinalMouse device. METHODS: Prospective case-study involving 48 @entity1 with definite @entity1726 . All @entity1 were recruited between September 2011 and September 2013 and included 22 dopa-na  ve, evaluated before and 3 months after initiation of treatment, and 26 @entity1 with response fluctuations studied during the "off" and "on" states. The SpinalMouse instrument, a computer-assisted mechanical hand-held device, designed to noninvasively assess the curvature of the spine was guided along the midline of the vertebral column in upright, full flexion, and full extension positions to objectively assess spinal posture. RESULTS: In the dopa-na  ve @entity1 , spinal incline in the upright position was 12.4  1.2   before and 7.6  1.3   after treatment; p=0.002. Corresponding area-under-the-curve (AUC) values were 131.7  8.0cm(2) and 87.1  7.3cm(2); p<0.0001. In the response fluctuations @entity1 , spinal incline was 13.3  1.3   in the "off" and 9.3  1.2   in the "on" period; p=0.015. Corresponding AUC values were 144.6  9.2cm(2) and 103.1  8.2cm(2); p<0.0001. CONCLUSIONS: This is the first study that objectively measured and quantified abnormalities of spinal posture in @entity1 with @entity1726 . Findings suggest that @entity3034 does have a beneficial effect on anterior flexion of the thoracolumbar spine, and thus indicate that the disorder of stooped posture in @entity1726 is mediated, at least in part, by @entity935 deficiency.
