Low Lymphatic Pumping Pressure in the Legs Is Associated with Leg XXXX and Lower Quality of Life in Healthy Volunteers.

@entity1 @entity4 @entity3194 @entity66
BACKGROUND: Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces, propelling it downstream back into circulation. The intrinsic lymph pump relies on the spontaneous contraction of lymphatic muscles to generate the force of pumping lymph (Plp). However, the association between leg @entity4 and reduced leg Plp in the general population is unknown. Therefore, this study determined the association of leg Plp and @entity4 complaints and quality of life in healthy @entity1 . METHODS AND RESULTS: A total of 465 healthy volunteers (78 @entity1 and 387 @entity1 , age 30-85 years) filled out a questionnaire and medical history to rule out severe @entity66 . Quality of life was assessed using the Medical Outcome Study Short Form 36 (SF36). Leg Plp was measured using minimally invasive @entity3194 fluorescence lymphography and an occlusion cuff technique while sitting. All @entity1 were divided into three groups according to the Plp values, as follows: @entity1 with Plp >40   mmHg in both legs, 20   mmHg-40   mmHg in either leg; and <20   mmHg in both legs were divided into the good (n=100), moderate (n=314), and poor (n=51) Plp groups, respectively. The survey revealed the poor leg Plp group was associated with more frequently complaints of leg @entity4 , as well as lower quality of life than the moderate and good Plp groups. CONCLUSION: Reduced leg Plp is significantly associated with leg @entity4 complaints and lower quality of life in the general population.
