Morphological features of regeneration of XXXX aortic endothelium after cryoinduced vascular damage.

@entity731 @entity10958 @entity95 @entity4653
Regeneration of endothelium after damage is an important factor, which limits the development of @entity731 . This study examines the topographical characteristics of regenerating endothelial cells (EC) in @entity95 aorta after de-endothelialization by cryodestruction. The effects of @entity10958 on these processes were also studied. Vessels were harvested from 6-month-old NZW @entity95 , 1 and 3 days after cryodestruction. The vessels were evaluated using @entity4653 ( @entity4653 ). One day after cryodestruction, there were defects in the endothelial monolayer in the zone of injury in saline treated animals. Large numbers of platelets and monocytes were observed in association with endothelium in the damaged zone. Three days after de-endothelialization the size of the area of the damage had decreased. On the surface of the new endothelial layer and below this defect, the number of adhering monocytes was increased, and many microdefects between endothelium could be seen. Administration of @entity10958 for 1 or 3 days after damage reduced the number of endothelium-adherent platelets and monocytes, and microdefects in endothelium. The feature of endothelial repair in @entity95 is a relatively large involvement of monocytes and platelets, which are visible below regenerated endothelium. Administration of @entity10958 essentially restored re-endothelialization and significantly decreased the number of adherent monocytes and microdefects in the new endothelium.
