Histopathologic study of XXXX lacrimal gland. Statistical analysis with special reference to aging.

@entity1 @entity1137 @entity82 @entity1560 @entity2617 @entity9849 @entity409 @entity2694 @entity1315 @entity194
PURPOSE: Histopathologic changes in @entity1 lacrimal gland were investigated, and the relation between histopathologic parameters and @entity1 age and sex, as well as the histopathologic differences between @entity2694 of the lacrimal gland were analyzed. METHODS: Samples of the main @entity1 lacrimal gland that included the @entity1315 were taken in 80 autopsies. A statistical analysis was made based on light microscope observations with the following histopathologic changes as parameters: (1) @entity82 (focal, lobular, and diffuse); (2) acinar @entity194 (focal, lobular, and diffuse); (3) periductal @entity82 ; (4) interlobular ductal dilatation; (5) interlobular ductal proliferation; (6) lymphocytic foci; (7) periductal @entity2617 ; and (8) @entity1560 . RESULTS: The incidences of these parameters in the @entity2694 ranged from 3.8% to 35.0%. Lobular @entity82 , @entity1137 , diffuse @entity82 , @entity194 , periductal @entity82 , @entity2617 , and @entity1560 were more frequent in the orbital lobes with statistical significance, whereas interlobular ductal dilatation was more frequent in the @entity1315 . There were statistically significant correlations between age and diffuse @entity82 , @entity194 , and periductal @entity82 in the orbital lobes of @entity1 , and periductal @entity82 in the @entity1315 of @entity1 . Diffuse @entity82 and @entity194 in the orbital lobes were observed more frequently in elderly @entity1 than in elderly @entity1 . CONCLUSIONS: Various histopathologic changes were observed in the @entity1 lacrimal gland. Diffuse @entity82 , @entity194 , and periductal @entity82 predominantly found in elderly @entity1 suggested a relation with @entity9849 sicca in postmenopausal @entity1 . The authors speculate the periductal @entity82 is related to the decrease in tear fluid outflow with age and that interlobular ductal dilatation in the @entity1315 may be caused by stenosis of the excretory duct in the fornix of conjunctiva. Ductal pathologic changes may be @entity409 .
