The effect of @entity27708 on neural breathing pattern in preterm XXXX .

@entity1 @entity27708 @entity386
BACKGROUND: @entity27708 is widely used to prevent and treat prematurity-associated @entity386 . AIMS: The aim of this study was to characterize the effect of @entity27708 on the neural control of breathing, especially central @entity386 , in premature @entity1 . STUDY DESIGN: Preterm @entity1 were evaluated for 30min before and 30min after @entity27708 loading (20mg/kg). A feeding tube including miniaturized sensors was used to measure the diaphragm electrical activity (Edi) waveform. Central @entity386 was defined as any period where the Edi waveform was flat for >5s. SUBJECTS: Seventeen preterm @entity1 with a mean age of three days and mean birth weight of 900 grams were evaluated. OUTCOME MEASURES: In addition to central @entity386 , several parameters including neural inspiratory time, neural respiratory rate, peak Edi, delta inspiratory change in Edi (phasic Edi) and minimum Edi on exhalation were measured. RESULTS: The majority of the @entity386 were short (5 to 10s) and the number of @entity386 correlated with birth weight (p=0.039). @entity27708 reduced significantly the number of 5-to-10-second-long central @entity386 during the 30-minute periods (12  11 to 7  7; p=0.02). @entity27708 increased both peak and phasic Edi leading to a significant increase in the diaphragm energy expenditure. CONCLUSIONS: Edi signal can be reliably measured and processed to study changes in premature @entity1 ' neural breathing. The beneficial effect of @entity27708 on the reduction of the number of @entity386 is mediated through stimulated neural breathing increasing the diaphragm energy expenditure.
