XXXX mutation is associated with higher risk of malignant transformation in @entity11 .

@entity1 @entity5 @entity11 @entity8724 @entity818 @entity876 @entity14051 @entity204
UNASSIGNED: Acquisition of @entity818 or @entity14051 mutation (IDHmut) is among the earliest genetic events that take place in the development of most @entity11 ( @entity11 ). IDHmut has been associated with longer overall @entity1 survival. However, its impact on @entity5 to be defined. A collection of 210 archived adult @entity11 previously stratified by IDHmut, @entity8724 methylation (MGMTmet), 1p/19q combined loss of heterozygosity (1p19qloh) and @entity876 immunopositivity (TP53pos) status was analyzed. We used multistate models to assess MT-free survival, considering one initial, one transient (MT), and one absorbing state ( @entity204 ). Missing explanatory variables were multiply imputed. Overall, although associated with a lower risk of @entity204 (HRDEATH  =  0.35, P  =  0.0023), IDHmut had a non-significantly higher risk of MT (HRMT  =  1.84; P  =  0.1683) compared to @entity818 wild type (IDHwt). The double combination of IDHmut and MGMTmet and the triple combination of IDHmut, MGMTmet and 1p/19qloh, despite significantly lower hazards for @entity204 (HRDEATH versus IDHwt: 0.35, P  =  0.0194 and 0.15, P  =  0.0008, respectively), had non-significantly different hazards for MT. Conversely, the triple combination of IDHmut/MGMTmet/ @entity876 pos, with a non-significantly different hazard for @entity204 , had a significantly higher hazard for MT than IDHwt (HRMT versus IDHwt: 2.83; P  =  0.0452). Although IDHmut status is associated with longer overall @entity1 survival, all IDHmut/MGMTmet subsets consistently showed higher risks of MT than of @entity204 , compared to IDHwt @entity11 . This supports the findings that molecular events relevant to @entity818 mutations impact early @entity11 development prior to malignant transformation.
