Stereotactic large core needle biopsy for all nonpalpable XXXX ?

@entity5 @entity1 @entity189 @entity1558
BACKGROUND: Stereotactic large-core needle biopsy (SLCNB) is a minimally invasive method for histological diagnosis of nonpalpable @entity1558 . We studied differences in @entity5 prevalence between a group of @entity1 referred through the national screening program and a non-screening group, and assessed whether the validity of SLCNB differed between these groups. METHODS: A group of non-selective, consecutive @entity1 presenting with a nonpalpable mammographic lesion, who participated in a recently conducted multicenter study regarding the accuracy of SLCNB in The Netherlands, were the basis for this study. Prevalence of @entity189 , predictive value of a benign diagnosis, sensitivity, and specificity rate of SLCNB were compared between the two groups. RESULTS: Of the 1029 lesions in 972 @entity1 included, 858 were evaluable. In 850/858 lesions (99.1%) the reason for referral was clear. The prevalence of @entity5 in the screening group (n = 511 lesions) was 64.0% (95%CI 59.8-68.2), versus 49.6% in the non-screening group (n = 339) (95%CI 44.2-54.9). Respective predictive values of a benign diagnosis on SLCNB were 97.0 versus 94.8% (non-significant). The sensitivity rates of SLCNB were 98.5% (screening; 95%CI 96.5-99.5) versus 95.2% (non-screening; 95%CI 90.8-97.9). Specificity rates were 97.8 (95%CI 94.5-99.4) and 99.4% (95%CI 96.8-100), respectively. CONCLUSION: Despite a significant difference in the prevalence of @entity189 , the accuracy of SLCNB did not show a statistically significant difference between both @entity1 groups. Therefore, SLCNB appears accurate in diagnosing nonpalpable @entity1558 both in screening and non-screening @entity1 groups.
