Childhood XXXX : Review of 317 cases.

@entity1 @entity3377 @entity221 @entity158 @entity382 @entity166
OBJECTIVE: To describe the main epidemiological, clinical, and laboratory features, treatment options and outcome in @entity1 with @entity3377 . METHODS: Retrospectively evaluated data were obtained from 317 pediatric @entity1 with @entity3377 that were treated at the University Clinic for @entity166 and Febrile Conditions in Skopje, during the period from 1989 to 2011. The medical records and follow-up protocols were used for evaluation. RESULTS: Childhood @entity3377 composed 317 (18.7%) of 1691 @entity1 with @entity3377 . The @entity1 were median 9 years old, ranging from 7 months to 14 years, and 201 (63.4%) were males. Family history was present in 197 (62.1%), and direct contact with animals occurred in 140 (44.2%) of the @entity1 . The dominant manifestations were @entity221 in 248 (78.2%), @entity158 in 228 (71.9%) and @entity382 in 216 (68.1%). Organ affection was present in 206 (65.0%) of the @entity1 . One hundred and six (33.4%) of the @entity1 were treated with combination composed of two, and 211 (66.6%) with three antimicrobial agents. Relapses were registered in 21 (6.6%), and therapeutic failures in 3 (0.9%) of the @entity1 . CONCLUSIONS: In endemic regions childhood @entity3377 represents a significant part of @entity1 cases. Wide spectrum of clinical manifestations, frequent affection of various organ systems and possibility of relapses show that @entity3377 could be a serious disease in this age group. The presence of @entity221 , @entity158 , sweating, and affection of various systems in @entity1 from endemic regions should alert pediatricians for the possibility of @entity3377 .
