[Aberrant topological properties of whole-brain functional network in chronic right-sided XXXX : a resting-state functional MRI study].

@entity1 @entity393 @entity1274 @entity5545
OBJECTIVE: To investigate the topological properties of the functional brain network in unilateral @entity1274 @entity1 . METHODS: In this study, we acquired resting-state BOLD- fMRI data from 19 right-sided SNHL @entity1 and 31 healthy controls with normal hearing and constructed their whole brain functional networks. Two-sample two-tailed t-tests were performed to investigate group differences in topological parameters between the USNHL @entity1 and the controls. Partial correlation analysis was conducted to determine the relationships between the network metrics and USNHL-related variables. RESULTS: Both USNHL @entity1 and controls exhibited @entity5545 in their brain functional networks within the range 0. 1 - 0. 2 of sparsity. Compared to the controls, USNHL @entity1 showed significant increase in characteristic path length and normalized characteristic path length, but significant decrease in global efficiency. Clustering coefficient, local efficiency and normalized clustering coefficient demonstrated no significant difference. Furthermore, USNHL @entity1 exhibited no significant association between the altered network metrics and the duration of USNHL or the severity of @entity393 . CONCLUSION: Our results indicated the altered topological properties of whole brain functional networks in USNHL @entity1 , which may help us to understand pathophysiologic mechanism of USNHL @entity1 .
