Primitive XXXX /Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis.

@entity1 @entity2828 @entity6196 @entity632 @entity4153 @entity4969 @entity5 @entity3778 @entity2879 @entity3833 @entity7634 @entity1891 @entity150 @entity21468 @entity715 @entity811 @entity1260
We report a rare case of primitive @entity4969 / @entity2828 ( @entity6196 /ES) arising from the urinary bladder. A 65-year-old @entity1 presented with @entity811 and @entity3833 . Computed tomography revealed an enlarged invasive @entity5 at the base of the bladder. No additional abnormal findings were disclosed by other diagnostic imaging methods. The surgical specimens showed small round cell @entity5 with positive staining for @entity3778 gene product ( @entity3778 ). EWS- @entity21468 fusion transcripts were detected by reverse transcriptase polymerase chain reaction and direct sequencing, confirming the diagnosis of @entity6196 /ES. The @entity1 developed swollen pelvic lymph nodes as well as multiple lung metastases at 8  months postoperatively. No effective results could be obtained even with systemic chemotherapy consisting of @entity1891 , @entity1260 , @entity632 and @entity2879 (VIDE) based on the EUROpean @entity5 Working Initiative of National Groups 1999 ( @entity7634 -E.W.I.N.G. 99) multinational trial. The @entity1 died of acute superior mesenteric artery @entity715 at 22  months postoperatively. @entity6196 /ES could have been included in past cases of @entity4153 because of the difficulty in its differential diagnosis. Exact diagnosis is crucial for deciding the treatment strategy for rare @entity150 consisting of small round cells.
