Protective action of XXXX compounds against aldehyde toxicants of cigarette smoke.

@entity1 @entity462 @entity167 @entity620 @entity406 @entity898 @entity9732 @entity15854 @entity5828 @entity42286 @entity35 @entity599 @entity8697 @entity3094
@entity3094 , @entity8697 , and @entity406 are important toxicants of cigarette smoke. Since @entity3094 is a toxicant common to both heavy @entity167 drinking and heavy cigarette smoking, protection studies were undertaken in @entity35 first against @entity3094 lethality and later against @entity8697 and @entity406 lethality. This paper summarizes findings from previously published studies. With @entity3094 (LD 90 dose/72 hrs.) protection studies were carried out by pretreatment with a high oral dose (2 mmoles/kg) of @entity462 and 17 other @entity599 compounds. Good protection (80% or more survivors) was obtained with @entity462 , @entity898 , @entity15854 . @entity5828 , @entity9732 , @entity42286 , and a combination (CTA) of @entity462 , @entity15854 . @entity5828 , and @entity620 . @entity898 , @entity42286 , and the combination CTA gave 100% protection (i.e. 100% survivors). With @entity8697 (LD 95 dose/72 hrs.), protection data showed 80% survivors with @entity462 and 95% with the combination CTA. With @entity406 (LD 95 dose/72 hrs.), protection resulted in 20% survivors with @entity462 and 55% with the combination CTA. However, protection against @entity406 lethality could be increased to 90% survivors by repeated dosing with @entity620 per se over a two day period prior to administration of @entity406 . Further animal experimentation is necessary before any extrapolation of these findings for @entity1 use can be considered. Due to current interest, the potential value of @entity898 as a protectant is also discussed.
