@entity1289 genotype and the ventilatory response to exertional XXXX .

@entity1 @entity336 @entity1289 @entity1568 @entity26 @entity133 @entity519 @entity358 @entity1576 @entity544
The "insertion" (I) rather than "deletion" (D) variant of the @entity1 @entity1289 ( @entity1289 ) gene is associated with both lower tissue @entity1289 activity and elite performance at high altitude. Three genotypes, II, ID and @entity336 , are thus represented in the population. The authors examined whether an improved ventilatory response to @entity519 exercise may contribute to this effect. Subjects (n=60; 37 male, mean+/-SEM age 23.6+/-0.6 yrs, 14 II, 30 ID, 16 @entity336 ) underwent incremental cardiopulmonary exercise testing to establish maximal @entity26 uptake and @entity1576 ( @entity1576 ). Four hours later, subjects exercised for 6 mins at 50% of the workload at @entity1576 . The protocol was repeated 15 mins later while breathing 12.5+/-0.5% @entity26 in @entity1568 . All subject characteristics were independent of genotype, as were data during normoxic exercise. However, the @entity519 -induced rise in minute ventilation was significantly greater among those of II genotype (39.6+/-4.1% versus 27.9+/-2.0% versus 28.4+/-2.2% for II versus ID versus @entity336 , respectively). These data are supported by a significantly greater decrease in end tidal @entity544 (consistent with an increase in @entity133 ) among those homozygous for the I allele (II -18.7+/-1.3%, ID -15.7+/-0.4%, @entity336 -15.1%+/-1.1). The ventilatory response to @entity519 exercise is influenced by @entity1289 genotype. Potential implications concern high altitude performance and the pathogenesis and management of @entity358 .
