Persistent XXXX : the Araba Phoenix of cardiology.

@entity1 @entity101 @entity28 @entity63 @entity66 @entity2299 @entity6 @entity409 @entity3979 @entity951 @entity741 @entity453
Percutaneous coronary intervention (PCI) has not been shown to reduce mortality in @entity1 with stable @entity453 ( @entity453 ). The long-term clinical success of PCI is defined as the persistent relief of signs and symptoms of @entity741 for more than 6 months after the index procedure. Data from large trials investigating the use of PCI in @entity1 with stable @entity453 show that @entity951 is still experienced in a large number of @entity1 one year after the procedure and that this proportion increases over time. These data are, however, largely from post-hoc analyses of studies powered to measure other end points. We conducted the first prospective study investigating the incidence of persistent @entity951 and inducible @entity63 in @entity1 with stable @entity453 undergoing PCI rated as 'successful' by the interventional cardiologist, and present an interim analysis of data from 220 @entity1 . The mean age of our @entity1 was 65 years; they were mostly male, mildly @entity28 , @entity101 and dyslipidemic. Most @entity1 had @entity66 affecting the left anterior descending artery and received a drug-eluting stent, and all @entity1 had a positive stress test before PCI. At the follow-up visit, which was performed within 4 weeks of the index procedure, 52% of @entity1 still had a positive stress test. Before PCI, 66% of @entity1 reported experiencing @entity951 on exertion. At the follow-up visit, one-third of those @entity1 were still experiencing @entity951 . @entity1 experiencing persistent @entity951 (21% of the study population) graded their symptoms as improved (66%), unchanged (33%) or worsened (1%) after the procedure. We hypothesize that coronary @entity409 is a possible cause of persistent @entity951 in this highly select group of @entity1 . Risk factors for @entity409 include @entity2299 , smoking and @entity6 . It is currently difficult to dissect the relative contributions of @entity3979 and @entity409 in precipitating @entity741 . A better understanding of these mechanisms could reduce the number of unnecessary PCI procedures. Moreover, treatment options in @entity1 who continue to experience @entity951 despite 'optimal' medical therapy and 'successful' PCI are urgently required.
