Management of high-grade XXXX : personal experience.

@entity1 @entity242 @entity5 @entity27418 @entity204 @entity1821
@entity242 are uncommon @entity5 arising from mesenchymal tissue, accounting for approximately 10% of soft-tissue @entity242 and less than 1% of all @entity5 . The most frequent subtypes of @entity242 are @entity1821 . Total surgical extirpation appears the only chance for @entity1 cure since medical therapies have shown little efficacy. We have analyzed our series of 32 @entity27418 that undergone surgical resection and with at least 5 years of follow-up. We have included 21 @entity1 who underwent a complete resection (R0) and 6 @entity1 who underwent an incomplete resection (R1). However, the operation's goal was a complete @entity5 resection with @entity5 -free resection margins. The 5-year survival was 85.7% when we performed a R0 resection, while it was 33.3% when we performed a R1 resection with a significant statistical difference (p = 0.02). Surgery is the gold standard for treatment of @entity1821 . Despite advances in diagnostic modalities, surgical techniques and the adoption of more aggressive procedure, such disease still has a propensity for local recurrence, even after an apparent complete resection. Therefore, locoregional recurrence remains the main cause of @entity204 in @entity1 with a @entity27418 . Moreover when the @entity5 recurs locally, the treatment of choice is to remove the recurrence. Our experience shows that a complete resection of primary lesions and further resection of recurrences early detected with CT examination could improve the overall survival of @entity1 with @entity27418 . Moreover in our series, the @entity1 who undergo R1 resection had a worse prognosis.
