@entity619 attenuates the embryotoxic effect of endometriotic peritoneal fluid in a XXXX model.

@entity1 @entity249 @entity19 @entity619 @entity46
PURPOSE: The in vitro fertilization (IVF) pregnancy rate of @entity1 with advanced stage @entity46 is nearly half that of the general population, suggesting incomplete targeting of the pathophysiology underlying @entity46 -associated @entity249 . Compelling evidence highlights inflammation as the etiologic link between @entity46 and @entity249 and a potential target for adjunctive treatment. The objective of this study was to examine the effect of @entity619 on @entity19 embryos exposed to @entity1 endometriotic peritoneal fluid (PF) using the established @entity19 embryo assay model. METHODS: PF was obtained from @entity1 with and without severe @entity46 . @entity19 embryos were harvested and randomly allocated to five groups of culture media conditions: (1) @entity1 tubal fluid (HTF), (2) HTF and 10  % PF from @entity1 without @entity46 , (3) HTF and 10  % PF from @entity1 with @entity46 (PF-E), (4) HTF with PF-E and 0.01  mcg/mL @entity619 , and (5) HTF with PF-E and 0.1  mcg/mL @entity619 . Embryos were cultured in standard conditions and evaluated for blastocyst development. RESULTS: A total of 266 @entity19 embryos were cultured. Baseline blastulation rates were 63.6  %. The addition of peritoneal fluid from @entity1 with @entity46 decreased the blastocyst development rate to 38.9  % (P   =   0.008). The addition of 0.1  mcg/mL of @entity619 to the culture media restored the blastulation rate to near baseline levels (61.2  %; P   =   0.019). CONCLUSIONS: The results of our in vitro study demonstrate the capacity of @entity619 to mitigate the deleterious impact of endometriotic PF on embryo development. If confirmed in vivo, @entity619 may prove a useful adjunct for the treatment of @entity46 -associated @entity249 .
