Predictive value of @entity130 for the development of @entity1315 in 21-day-old @entity35 : an MRI approach using the XXXX - @entity2134 model.

@entity1 @entity131 @entity2134 @entity1315 @entity302 @entity35 @entity1091 @entity159 @entity130
PURPOSE: @entity1 with @entity1315 ( @entity1315 ) usually had an initial precipitating @entity130 . However, @entity302 does not develop in all @entity1 who have undergone an early insult. As in @entity1 , the consequences of the @entity1091 - @entity2134 -induced @entity159 ( @entity159 ) are age dependent, and only a subset of 21-day-old @entity35 will develop @entity302 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity35 . METHODS: @entity159 was induced in 21-day-old @entity35 by the injection of @entity1091 and @entity2134 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity159 . RESULTS: Three populations of @entity35 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity35 did not develop @entity302 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity159 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity159 ; @entity302 developed in all these animals. The third population of @entity35 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity302 developed in all these @entity35 . Only in a subpopulation of the 21-day-old @entity35 with @entity302 did @entity131 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity159 play a critical role for the installation of the @entity302 networks and the development of @entity302 .
