Bioassay of XXXX for possible carcinogenicity.

@entity8 @entity19 @entity5 @entity4336 @entity63520 @entity35 @entity157
A bioassay for possible carcinogenicity of technical-grade @entity63520 was conducted using Osborne-Mendel @entity35 and B6C3F1 @entity19 . @entity63520 in @entity4336 oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The chemical was administered 5 days a week, cyclically for 44 of 78 weeks in @entity35 and continuously for 78 weeks in @entity19 , followed by an observation period of 33 or 34 weeks for @entity35 and 12 or 13 weeks for @entity19 . The high and low time-weighted average dosages of @entity63520 were, respectively, 423 and 212 mg/kg/day for male and female @entity35 and 1179 and 590 mg/kg/day for male and female @entity19 . For each species, 20 animals of each sex were placed on test as vehicle controls. These animals were gavaged with pure @entity4336 oil at the same rate as the high dose group of the same sex. Twenty animals of each sex were placed on test as untreated controls for each species. These animals were not intubated. A statistically significant association between increased dosage and accelerated mortality was observed in male and female @entity35 but not in @entity19 of either sex. @entity8 was observed in all groups of treated animals. Statistical evaluation of the incidences of @entity157 revealed a significant positive association between @entity63520 administration and @entity5 incidence in both male and female @entity19 . No statistical significance was attributed to the incidence of any @entity5 in @entity35 of either sex. No evidence was provided for the carcinogenicity of the compound in Osborne-Mendel @entity35 . It is concluded that under the conditions of this bioassay, @entity63520 was carcinogenic in B6C3F1 @entity19 , inducing @entity157 in both sexes.
