Low computed tomography coronary artery XXXX scores in familial longevity: the Leiden Longevity Study.

@entity1 @entity16133 @entity65 @entity460
Offspring of long-lived parents have a low prevalence of @entity65 in middle age. The purposes of this study were to investigate @entity460 scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery @entity460 score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. @entity460 scores were analyzed separately for sexes. Subjects were grouped by very low @entity460 score  <=10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between @entity460 scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower @entity460 scores than controls. In @entity1 , 34 % of offspring had score  <=10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08-3.7, p = 0.028). In @entity1 , 70 % of offspring had score  <=10 versus 54 % of controls ( @entity16133 , 95 % CI 1.13-3.4, p = 0.019). Differences remained significant after correction for age ( @entity1 , p = 0.043 and @entity1 , p = 0.003) and further correction for major risk factors in @entity1 , indicating genetic influence for lower @entity460 scores. In @entity1 , the association was found to be influenced by cardiovascular risk factors. @entity1 and @entity1 with a familial propensity to become long-lived have lower coronary artery @entity460 scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident @entity65 .
