Outcome of total pelvic exenteration for locally recurrent XXXX .

@entity1 @entity5 @entity188
BACKGROUND/AIMS: Local recurrence occurs in 10 to 30% of @entity1 with @entity5 following curative resection. However treatment of choice remains controversial. We assessed the results of total pelvic exenteration for locally recurrent @entity188 retrospectively. METHODOLOGY: We reviewed medical charts of 45 @entity1 with @entity5 who underwent curative total pelvic exenteration for local recurrence. The cause of recurrence was classified into four groups: anastomotic, surgical cut-end, implantation, and lymphatic based on pathologic findings and computed tomography. Long-term survival was correlated with clinicopathologic variables. RESULTS: Postoperative morbidity was 77.8% and in-hospital death occurred in 13.3% of @entity1 . The overall 5-year survival rate was 14.1%. The 5-year survival rates stratified according to the expectation of curability were 31.6% for absolutely curative resection, 7.8% for relatively curative resection, and 0% for non-curative resection. Multivariate analysis revealed that the disease-free interval was the only independent prognostic factor. There was no benefit from perioperative radiation or intraoperative continuous pelvic peritoneal perfusion of the pelvis. CONCLUSIONS: Total pelvic exenteration for local recurrence of @entity5 can achieve long-term survival when curative resection is possible and the disease-free interval is long.
