[Experimental study on the option of antispasmodic drugs for radial artery in elderly @entity1 with XXXX ].

@entity1 @entity1242 @entity3988 @entity3302 @entity453 @entity2553
OBJECTIVE: To compare the relief effect of @entity3988 , @entity3302 and @entity1242 on radial @entity2553 in elderly @entity1 with @entity453 . METHODS: Sixty @entity1 aged beyond 70 years underwent coronary artery bypass grafting (CABG) with autologous radial artery from July 2009 to March 2010. Redundant radial artery was collected and the relief function of different drugs was evaluated through "organ bath" technique in vitro. All the @entity1 were randomly divided into 3 groups based on different antispasmodic drugs: @entity3988 , @entity3302 and @entity1242 . Thirty seconds free blood flow of radial artery and hemodynamic parameters (heart rate, mean arterial pressure and central venous pressure) were assessed before and after intra-radial administration of @entity3988 , @entity3302 and @entity1242 in vivo. RESULTS: All three drugs could relieve radial @entity2553 in different levels and the eventual relief rate was over 80%. Only @entity1242 could relax radial artery completely, the relief capacity of @entity1242 , @entity3988 and @entity3302 decreased in order. There was no significant difference in the hemodynamic parameters before and after the injection. Blood flow of radial artery increased in @entity1242 group [(42    10) ml/30 s vs. (28    7) ml/30 s, P < 0.05] while there was no significant difference in @entity3988 [(23    10) ml/30 s vs. (25    8) ml/30 s, P > 0.05] and @entity3302 group [(25    10) ml/30 s vs. (24    9), P > 0.05]. CONCLUSIONS: @entity1242 could relieve @entity2553 of radial artery effectively and increased blood flow. @entity1242 is the suitable antispasmodic drug for radial artery in the elderly @entity1 with @entity453 compare with @entity3988 and @entity3302 .
