Residual hippocampal XXXX in asphyxiated term neonates.

@entity1 @entity2806 @entity63 @entity75 @entity1315 @entity194 @entity1763
BACKGROUND AND PURPOSE: Previous studies have shown the hippocampus and basal ganglia to be highly sensitive to @entity63 . The authors' aim was to evaluate the long-term effects of perinatal @entity1763 (PA) on the hippocampus and caudate nucleus in a group of @entity1 born at term and who met the criteria for @entity2806 ( @entity2806 ). Additionally, the authors looked for damage in other brain regions using voxel-based morphometry (VBM). METHODS: The sample consisted of 13 @entity1 (8 @entity1 and 5 @entity1 ) with a mean age at study of 16.23 years (+/- 2.89) with antecedents of perinatal @entity1763 , diagnosed as moderate @entity2806 . A group of 13 healthy adolescents matched for age, sex, educational level, and social background were recruited as a comparison group. MR scans were acquired on a 1.5T Signa (General Electric, Milwaukee, WI) to evaluate hippocampal and caudate volumes and to perform VBM analysis. Finally, Rey's Auditory Verbal Learning Test was administered to evaluate verbal long-term memory. RESULTS: @entity2806 @entity1 were found to have bilateral hippocampal @entity194 (P = .015) and gray matter damage in @entity1315 . The caudate nucleus showed no atrophic changes in PA @entity1 , and VBM analysis did not reveal other consistent @entity75 . Verbal long-term memory was slightly worse in @entity2806 @entity1 . CONCLUSIONS: These findings indicate that PA produces hippocampal and other nonspecific long-term damage, which cannot be compensated for by plasticity mechanisms. However, this damage does not preclude normal development and scholarship.
