Association between absolute volumes of lung spared from low-dose irradiation and radiation-induced @entity651 after intensity-modulated radiotherapy in XXXX : a retrospective analysis.

@entity1 @entity5 @entity2 @entity651 @entity358
UNASSIGNED: The aim of this study was to investigate the association between absolute volumes of lung spared from low-dose irradiation and radiation-induced @entity651 (RILI) after intensity-modulated radiotherapy (IMRT) for @entity2 . The normal lung relative volumes receiving greater than 5, 10, 20 and 30 Gy (V5-30) @entity358 ( @entity358 ), and absolute volumes spared from greater than 5, 10, 20 and 30 Gy (AVS5-30) for the bilateral and ipsilateral lungs of 83 @entity1 were recorded. Any association of clinical factors and dose-volume parameters with Grade >= 2 RILI was analyzed. The median follow-up was 12.3 months; 18 (21.7%) cases of Grade 2 RILI, seven (8.4%) of Grade 3 and two (2.4%) of Grade 4 were observed. Univariate analysis revealed the located lobe of the @entity5 . V5, V10, V20, @entity358 of the ipsilateral lung, V5, V10, V20, V30 and @entity358 of the bilateral lung, and AVS5 and AVS10 of the ipsilateral lung were associated with Grade >= 2 RILI (P < 0.05). Multivariate analysis indicated AVS5 of the ipsilateral lung was prognostic for Grade >= 2 RILI (P = 0.010, OR = 0.272, 95% CI: 0.102-0.729). Receiver operating characteristic curves indicated Grade >= 2 RILI could be predicted using AVS5 of the ipsilateral lung (area under curve, 0.668; cutoff value, 564.9 cm(3); sensitivity, 60.7%; specificity, 70.4%). The incidence of Grade >= 2 RILI was significantly lower with AVS5 of the ipsilateral lung >= 564.9 cm(3) than with AVS5 < 564.9 cm(3) (P = 0.008). Low-dose irradiation relative volumes and @entity358 of the bilateral or ipsilateral lung were associated with Grade >= 2 RILI, and AVS5 of the ipsilateral lung was prognostic for Grade >= 2 RILI for @entity2 after IMRT.
