Longitudinal effects of systemic @entity32 markers on XXXX .

@entity32 @entity2002 @entity6730 @entity6 @entity28 @entity102 @entity92 @entity2521
AIM: Systemic low-grade @entity32 represents a central hallmark of @entity102 and has been proposed as the underlying mechanism linking factors like @entity28 or @entity6 with @entity2521 . However, the impact of inflammatory markers on @entity2521 has not yet been investigated. MATERIALS AND METHODS: The study population comprised 1784 subjects from the Study of Health in Pomerania with complete 11-year follow-up. @entity2002 and white blood cell (WBC) counts were measured as markers of @entity32 . @entity2521 was assessed by @entity92 ( @entity92 ), clinical @entity6730 (CAL) and the CDC/AAP case definition. RESULTS: Multilevel regression analyses revealed significant coefficients for the impact of both @entity32 markers on the percentage of sites with @entity92 /CAL >= 3mm. Increases in @entity2002 about 1 g/l were associated with 3.0% and 2.7% more sites with @entity92 /CAL >= 3mm, respectively. Consistent associations were found using mean values of @entity92 /CAL but not using missing teeth or caries. Regarding the CDC/AAP case definition, 11-year changes in @entity2002 and WBC counts were significantly associated with >= 1 category progression (OR: 1.36 and 1.11). CONCLUSIONS: @entity2002 levels and WBC counts showed consistent long-term associations with @entity92 , CAL and the CDC/AAP case definition. Results indicate that systemic low-grade @entity32 might indeed represent one possible pathway for effects of @entity28 , @entity6 or other chronic inflammatory conditions on @entity2521 . This article is protected by copyright. All rights reserved.
