Polymeric electrospun scaffolds: neuregulin encapsulation and biocompatibility studies in a model of XXXX .

@entity2140 @entity65 @entity741 @entity35 @entity204 @entity32599
@entity65 represents one of the major health challenges in modern times and is the number one cause of @entity204 globally. Thus, numerous studies are under way to identify effective cell- and/or @entity2140 ( @entity2140 )-based therapies for repairing damaged cardiac tissue. In this regard, improving the engraftment or survival of regenerative cells and prolonging @entity2140 exposure have become fundamental goals in advancing these therapeutic approaches. Biomaterials have emerged as innovative scaffolds for the delivery of both cells and proteins in tissue engineering applications. In the present study, electrospinning was used to generate smooth homogenous polymeric fibers, which consisted of a poly(lactic-co-glycolic acid) (PLGA)/NCO-sP(EO-stat-PO) polymer blend encapsulating the cardioactive @entity2140 , @entity32599 ( @entity32599 ). We evaluated the biocompatibility and degradation of this @entity32599 -containing biomaterial in a @entity35 model of @entity741 . Histological analysis revealed the presence of an initial acute inflammatory response after implantation, which was followed by a chronic inflammatory phase, characterized by the presence of giant cells. Notably, the scaffold remained in the heart after 3 months. Furthermore, an increase in the M2:M1 macrophage ratio following implantation suggested the induction of constructive tissue remodeling. Taken together, the combination of @entity32599 -encapsulating scaffolds with cells capable of inducing cardiac regeneration could represent an ambitious and promising therapeutic strategy for repairing diseased or damaged myocardial tissue.
