Nomograms to Predict Recurrence-Free and Overall Survival After Curative Resection of XXXX .

@entity1 @entity146 @entity5 @entity1636 @entity701 @entity1349
Importance: @entity1636 ( @entity1636 ) is a rare @entity146 , and the prognostic factors associated with long-term outcomes after surgical resection remain poorly defined. Objectives: To define clinicopathological variables associated with @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) after curative surgical resection of @entity1636 and to propose nomograms for individual risk prediction. Design, Setting, and @entity1 : Nomograms to predict @entity1349 and @entity1349 after surgical resection of @entity1636 were proposed using a multi-institutional cohort of @entity1 who underwent curative-intent surgery for @entity1636 at 13 major institutions in the United States between March 17, 1994, and December 22, 2014. The dates of our study analysis were April 15, 2015, to May 12, 2015. Main Outcomes and Measures: The discriminative ability and calibration of the nomograms to predict @entity1349 and @entity1349 were tested using C statistics, calibration plots, and Kaplan-Meier curves. Results: In total, 148 @entity1 who underwent surgery for @entity1636 were included in the study. The median @entity1 age was 53 years, and 65.5% (97 of 148) of the @entity1 were female. One-third of the @entity1 (35.1% [52 of 148]) had a functional @entity5 , and the median @entity5 size was 11.2 cm. Most @entity1 (77.7% [115 of 148]) underwent R0 resection, and 8.8% (13 of 148) of the @entity1 had N1 disease. Using backward stepwise selection of clinically important variables with the Akaike information criterion, the following variables were incorporated in the prediction of @entity1349 : @entity5 size of at least 12 cm (hazard ratio [HR], 3.00; 95% CI, 1.63-5.70; P   <   .001), positive nodal status (HR, 4.78; 95% CI, 1.47-15.50; P   =   .01), stage III/IV (HR, 1.80; 95% CI, 0.95-3.39; P   =   .07), @entity701 -secreting @entity5 (HR, 2.38; 95% CI, 1.27-4.48; P   =   .01), and capsular invasion (HR, 1.96; 95% CI, 1.02-3.74; P   =   .04). Factors selected as predicting @entity1349 were @entity5 size of at least 12 cm (HR, 1.78; 95% CI, 1.00-3.17; P   =   .05), positive nodal status (HR, 5.89; 95% CI, 2.05-16.87; P   =   .001), and R1 margin (HR, 2.83; 95% CI, 1.51-5.30; P   =   .001). The discriminative ability and calibration of the nomograms revealed good predictive ability as indicated by the C statistics (0.74 for @entity1349 and 0.70 for @entity1349 ). Conclusions and Relevance: Independent predictors of survival and recurrence risk after curative-intent surgery for @entity1636 were selected to create nomograms predicting @entity1349 and @entity1349 . The nomograms were able to stratify @entity1 into prognostic groups and performed well on internal validation.
