Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female XXXX similar to that in aged males.

@entity1 @entity32 @entity2931 @entity19 @entity35
Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions have been observed in @entity35 , with males showing higher oxidation and immunosenescence than females of the same age. Oestrogens are sex hormones that actively participate in modulating the @entity1 immune function and, therefore, the age-related impairment of the immune response is drastically accelerated in females during the menopausal transition. Ovariectomy in rodents constitutes a good model for mimicking @entity1 oestrogen loss and thus the menopausal situation. Recently, we have shown the deleterious effects of @entity2931 loss on several functions of leukocytes from immune organs in @entity35 and @entity19 . In addition, ovariectomised @entity35 show similar levels in these immune functions to those in males. The present work studied several functions as well as inflammatory and oxidative stress parameters in @entity19 peritoneal macrophages and lymphocytes from old sham and ovariectomised females, as well as in males of the same age. In general, the results show that females, which have a higher immune response and a lower oxidation and @entity32 than males, appear similar to males in the parameters studied when they have lost oestrogens by ovariectomy. Thus, these data support the positive role of @entity2931 in the immune function through the ageing process.
