Electroporation therapy for T1 and T2 XXXX .

@entity5 @entity1 @entity1732
CONCLUSION: Electroporation therapy appears to be a safe treatment achieving excellent @entity5 control and very good functional results in our study and it should be further clinically evaluated. OBJECTIVES: The objectives of this study were to assess @entity5 control, survival, and effects on speech and eating after treatment of @entity5 with electroporation therapy, a new local therapeutic modality. In this approach intracellular accumulation of a chemotherapeutic agent is achieved by using a locally applied electrical field. METHODS: Fifteen @entity1 with primary T1 and T2 @entity5 were treated with electroporation therapy with intratumorally administered @entity1732 . Postoperative radiotherapy was performed when the @entity5 infiltration was 5 mm or more. The follow-up time was 24 months for the surviving @entity1 and 20.4 months overall. The effects on eating and speech were assessed using the PSS-HN scale and voice recordings. RESULTS: No local recurrence was recorded in any @entity1 during the follow-up. Three @entity1 died, two from progressive regional disease. Of the 12 surviving @entity1 , 2 @entity1 had regional recurrence and 10 @entity1 including the 5 @entity1 treated with EPT alone were @entity5 -free both locally and regionally at the last follow-up. The functional outcome for speech and eating were very good.
