XXXX reduces @entity1 monocyte mobility and adhesion in vitro.

@entity1 @entity32 @entity1357 @entity9172 @entity3089 @entity3090 @entity2842 @entity56 @entity2393
BACKGROUND AND PURPOSE: Monocytes/macrophages are an important population of immune inflammatory cells that have diverse effector functions in which their mobility and adhesion play a very relevant role. @entity3089 ( @entity3090 ), a major component of green tea, has been reported to have anti- @entity56 and anti-inflammatory activities, but its effects on monocytes remain to be determined. Here we investigated the effects of @entity3090 on the migration and adhesion of monocytes. EXPERIMENTAL APPROACH: We used a @entity1 monocyte cell line ( @entity1357 ) to analyse the effects of treatment with @entity3090 under non-cytotoxic conditions on the expression levels of the @entity2842 ( @entity2842 ) and of the @entity9172 ( @entity9172 ) and on the activation of @entity2393 . A functional validation was carried out by evaluating the inhibitory effect of @entity3090 on monocyte adhesiveness and migration in vitro. KEY RESULTS: Treatment of @entity1357 cells with @entity3090 decreased @entity2842 and @entity9172 gene expression, together with @entity2842 secretion and @entity9172 expression at the cell surface. @entity3090 also inhibited @entity2393 activation. The effects on these molecular targets were in agreement with the @entity3090 -induced inhibition of @entity1357 migration in response to @entity2842 and adhesion to fibronectin. CONCLUSIONS AND IMPLICATIONS: Under our experimental conditions, @entity3090 treatment inhibited the migration and adhesion of monocytes. These inhibitory effects of @entity3090 on monocyte function should be considered as a promising new anti-inflammatory response with a potential therapeutic role in the treatment of @entity32 .
