Incidence and risk factors for severe and symptomatic XXXX in type 1 @entity6 . Results of the HYPOS-1 study.

@entity1 @entity16 @entity6 @entity4053
OBJECTIVE: @entity4053 is common in @entity6 ( @entity6 ). We aimed to update the incidence of severe and symptomatic @entity4053 and investigate several correlated factors. METHODS: In this multicenter, observational retrospective study, the data of 206 @entity6 @entity1 from a sample of 2,229 consecutive @entity1 seen at 18 @entity6 clinics were analyzed. Sociodemographic and clinical characteristics, severe @entity4053 in the past 12  months, and symptomatic @entity4053 in the past 4  weeks were recorded with a self-report questionnaire and a clinical form during a routine visit. Poisson multivariate models were applied. RESULTS: A minority of @entity1 accounted for the majority of both severe and symptomatic episodes. The incidence rate (IR) of severe @entity4053 was 0.49 (0.40-0.60) events/ @entity1 -years. The incidence rate ratio (IRR) was higher in @entity1 with previous severe @entity4053 (3.71; 2.28-6.04), @entity16 (4.16; 2.14-8.05), long duration (>20  years, 2.96; 1.60-5.45), and on polypharmacy (1.24; 1.13-1.36), but it was lower when a complication was present. The IR of symptomatic @entity4053 was 53.3 events/ @entity1 -years, with an IRR significantly higher among @entity1 or @entity1 with better education, or shorter duration or on pumps. The IRR was lower in @entity1 with higher BMI or @entity16 or aged more than 50  years. CONCLUSIONS: Fewer than 20  % of @entity6 @entity1 are free from @entity4053 , with one in six having experienced at least one severe episode in the last year. The distribution is uneven, with a tendency of episodes to cluster in some @entity1 . Severe and symptomatic episodes have different correlates and reflect different conditions.
