Symptomatic spinal dissemination of XXXX .

@entity1 @entity932 @entity5 @entity816 @entity204 @entity463
OBJECT: Symptomatic spinal dissemination of @entity5 is rarely found except at autopsy. This study evaluated the clinical incidence and characteristics of spinal dissemination and the effect on outcome. @entity1 AND METHODS: @entity1 treated for primary @entity5 , including 33 with @entity816 and 35 with @entity463 , at our department between 1997 and 1999 were followed up until April 30, 2001. Head magnetic resonance (MR) imaging of all @entity1 was obtained every 2-3 months. Signs and symptoms of leptomeningeal spread were checked at monthly outpatient examinations. Spinal MR imaging was performed if any symptoms indicating spinal dissemination were found. RESULTS: Median survival times of @entity1 with @entity816 and @entity463 were 40.5 and 16.0 months, respectively. Seventeen @entity1 (25%) developed @entity932 and 15 of these died. Six @entity1 (8.8%), one with @entity816 and five with @entity463 , developed spinal dissemination. All @entity1 with spinal dissemination also had @entity932 . Five of the six @entity1 died, despite systemic radiochemotherapy in four @entity1 . All @entity1 died of extensive whole brain and spinal dissemination or nodular mass enlargement at the upper cervical cord, not of local massive @entity5 progression. CONCLUSIONS: Symptomatic spinal dissemination of @entity5 is not so rare, and is the cause of @entity204 . The relatively high incidence of symptomatic leptomeningeal dissemination must be considered in the treatment of malignant @entity816 .
