Candida species differ in their interactions with immature XXXX gastrointestinal epithelial cells.

@entity1 @entity6923 @entity3465 @entity344 @entity5132 @entity536
Life-threatening @entity344 of @entity3465 are highly associated with @entity6923 . This implicates the premature GI tract as an important site for invasion by Candida. Invasive interactions of Candida spp. with immature enterocytes have heretofore not been analyzed. Using a primary immature @entity1 enterocyte line, we compared the ability of multiple isolates of different Candida spp. to penetrate, injure, and induce a cytokine response from host cells. Of all the Candida spp. analyzed, @entity5132 had the greatest ability to penetrate and injure immature enterocytes and to elicit IL-8 release (p < 0.01). In addition, @entity5132 was the only Candida spp. to form filamentous hyphae when in contact with immature enterocytes. Similarly, a @entity5132 mutant with defective hyphal morphogenesis and invasiveness had @entity536 for immature enterocytes (p < 0.003). Thus, hyphal morphogenesis correlates with immature enterocyte penetration, injury, and inflammatory responses. Furthermore, variability in enterocyte injury was observed among hyphal-producing @entity5132 strains, suggesting that individual organism genotypes also influence host-pathogen interactions. Overall, the finding that Candida spp. differed in their interactions with immature enterocytes implicates that individual spp. may use different pathogenesis mechanisms.
