Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Carcinoma of the Transverse Colon in a Young XXXX .

@entity1 @entity66 @entity5 @entity984 @entity3041 @entity876 @entity3546 @entity1442 @entity1321 @entity14 @entity490 @entity817 @entity694
UNASSIGNED: We report a case of a 14-year-old female with primary @entity694 . She was hospitalized after presenting with @entity490 and signs of @entity1321 . There was no health antecedent or family history of @entity5 . Physical examination revealed a distended abdomen. Tenderness was elicited to palpation of the right lower quadrant. Magnetic resonance imaging of the abdomen revealed obstructive signs, with a constricting lesion in the mid-transverse colon of probable neoplastic nature. Laparoscopic segmental resection of the colon was followed by standard right hemicolectomy. A circumferential mid-transverse @entity5 was diagnosed as primary @entity14 ( @entity14 ) of signet-ring cell type, AJCC stage IIIC, Dukes' C stage. On the basis of immunohistochemistry and clinical data, hereditary nonpolyposis and hamartomatous @entity14 were excluded. Involvement of either the @entity876 , @entity817 , or @entity984 genes was ruled out by immunohistochemistry profiling and genetic testing. The @entity5 was categorized as sporadic. The possibility of activation of the Wnt signaling pathway was suspected, because of a defective turnover of the @entity3546 protein. Postoperatively, the @entity1 was treated with both systemic and intra-abdominal adjuvant chemotherapy, including oxaliplatin. Between 18 and 24 months after diagnosis, @entity5 recurrences were detected. The @entity1 underwent bilateral oophorectomies for Krukenberg @entity5 and received salvage chemotherapy. Recently, additional recurrent metastatic @entity66 caused @entity3041 . The retroperitoneal mass was debulked and a ureteric stent was placed. At the time of this writing, 43 months after diagnosis, the @entity1 is receiving FOLFOX chemotherapy combined with panitumumab. @entity14 of childhood is exceedingly rare, generally develops in the setting of unrecognized genetic predisposing factors to @entity5 , presents with @entity1442 , is high grade, and tends to have dismal prognosis.
