Polymorphisms and expression of toll-like receptors in XXXX .

@entity1 @entity9063 @entity72206 @entity6344 @entity2743 @entity2621 @entity1669 @entity72207 @entity6801 @entity38465 @entity6438 @entity15933 @entity64800
UNASSIGNED: @entity2743 ( @entity2743 ) and @entity2621 ( @entity2621 ) are @entity1669 ( @entity1669 ). Prognosis of @entity1669 varies in each @entity1 . Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. @entity38465 is a transcription factor of @entity6438 and @entity6801 . In this study, we examined the association of TLR expression and TLR and @entity38465 polymorphisms with the development and prognosis of @entity1669 . The ratio of intracellular @entity6438 (iTLR7) and iTLR9 intensities in B cells was lower in @entity1 with @entity2743 in remission than in @entity1 with intractable @entity2743 (p   =   0.0007). The frequency of G allele of @entity6438 @entity72206   @entity9063 polymorphism was significantly higher in male @entity1 with @entity2743 and intractable @entity2743 than in control subjects (p   =   0.0062 and 0.0173, respectively). The frequencies of T allele of @entity6801 @entity15933 @entity6344 polymorphism and C allele of @entity6801 @entity64800 @entity6344 polymorphism were significantly higher in @entity1 with intractable @entity2743 who had GG genotype of @entity6438 @entity72206 polymorphism, which is associated with higher @entity6438 expression, than in @entity1 with @entity2743 in remission (p   =   0.0334 and 0.0023, respectively). The frequencies of AA genotype and A allele of @entity38465 @entity72207 polymorphism were significantly higher in @entity1 with @entity2743 than in @entity1 with @entity2621 (p   =   0.0406 and 0.0316, respectively). These results suggested that the ratio of iTLR7 and iTLR9 intensities was associated with the development and intractability of @entity2743 and that @entity6438 and @entity38465 polymorphisms were associated with the development of @entity2743 .
