Dietary Management of Labrador Retrievers with Subclinical XXXX .

@entity235 @entity53073 @entity409
BACKGROUND: Genetic and environmental factors, including @entity53073 , contribute to the pathogenesis of @entity409 in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. OBJECTIVE: To investigate the effect of a @entity53073 , high-zinc diet on hepatic copper concentration in Labrador retrievers with increased hepatic copper concentrations. ANIMALS: Twenty-eight clinically healthy, client-owned Labrador retrievers with a mean hepatic copper concentration of 919      477  mg/kg dry weight liver (dwl) that were related to @entity235 previously diagnosed with clinical @entity409 . METHODS: Clinical trial in which @entity235 were fed a diet containing 1.3      0.3  mg copper/Mcal and 64.3      5.9  mg zinc/Mcal. @entity409 concentrations were determined in liver biopsy samples approximately every 6  months. Logistic regression was performed to investigate effects of sex, age, initial hepatic copper concentration and pedigree on the ability to normalize hepatic copper concentrations. RESULTS: In responders (15/28 @entity235 ), hepatic copper concentrations decreased from a mean of 710      216  mg/kg dwl copper to 343      70  mg/kg dwl hepatic copper after a median of 7.1  months (range, 5.5-21.4  months). @entity235 from a severely affected pedigree were at increased risk for inability to have their hepatic copper concentrations normalized with dietary treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: Feeding a @entity53073 , high-zinc diet resulted in a decrease in hepatic copper concentrations in a subset of clinically normal Labrador retrievers with previous @entity409 . A positive response to diet may be influenced by genetic background. Determination of clinical benefit requires further study.
