Apoptosis in XXXX : relation with radiation treatment results.

@entity1 @entity5 @entity1711 @entity150 @entity1710
PURPOSE: Radiotherapy is widely used in the treatment of @entity150 . The search for biological parameters that could select @entity1 who will respond to radiation treatment has become essential. The aim of this study is to assess whether the pretreatment apoptotic index is useful in predicting local control and survival in a group of @entity150 @entity1 treated by radiotherapy. METHODS AND MATERIALS: Fifty-five @entity1 with invasive @entity150 treated between 1983 and 1996 were included in this study. Radiotherapy was given to a median dose of 66 Gy, mean 63.28 Gy, in 1.8-2 Gy daily fractions. Apoptotic cells were studied in @entity1710 - @entity1711 slides. Clinicopathological @entity5 characteristics were studied in relation to the apoptotic index, and as prognostic factors for local control and survival in both univariate and multivariate analysis. RESULTS: Pretreatment apoptotic indexes were related to @entity5 stage, mitotic index, and Ki67 proliferation index. Five-year actuarial local control for the whole group was 45%. @entity1 with @entity5 showing low pretreatment apoptotic indexes had better local control (p < 0.037) and survival (p < 0.01) than highly apoptotic @entity5 . @entity5 stage (T2 vs. T3-4) and the pretreatment apoptotic index were significant predictive factors for local control and survival in multivariate analysis. CONCLUSIONS: The pretreatment apoptotic index is useful in predicting the clinical outcome of @entity150 @entity1 treated by radiotherapy. @entity5 characteristics could allow the selection of @entity1 for different treatment strategies.
