@entity11 : XXXX -enhanced Molecular MR Imaging and Optical Imaging for Potential Intraoperative Delineation of Tumor Margins.

@entity5 @entity32735 @entity32736 @entity11 @entity35
UNASSIGNED: Purpose To investigate the possibility of using @entity32735 ( @entity32736 )-enhanced molecular magnetic resonance (MR) imaging and optical imaging to identify the true margins of @entity11 . Materials and Methods The animal protocol was approved by the institutional animal care and use committee. Thirty-six @entity35 with @entity11 were randomized into six groups of six @entity35 . Five groups were euthanized 15, 30, 60, 120, and 240 minutes after intravenous administration of 6 mg/kg of @entity32736 , while one group received only saline solution as a control group. After craniotomy, optical imaging and T1-weighted MR imaging were performed to identify the @entity5 margins. One-way analysis of variance was used to compare optical photon intensity and MR imaging signal-to-noise ratios. Histologic analysis was performed to confirm the intracellular uptake of @entity32736 by @entity5 cells and to correlate the @entity5 margins delineated on both optical and MR images. Results Both optical imaging and T1-weighted MR imaging showed @entity5 margins. The highest optical photon intensity (2.6 * 10(8) photons per second per mm(2)    2.3 * 10(7); analysis of variance, P < .001) and MR signal-to-noise ratio (77.61    2.52; analysis of variance, P = .006) were reached at 15-30 minutes after administration of @entity32736 , with continued @entity5 visibility at 2-4 hours. Examination with confocal microscopy allowed confirmation that the fluorescence of optical images and MR imaging T1 enhancement exclusively originated from @entity32736 that accumulated in the cytoplasm of @entity5 cells. Conclusion @entity32736 -enhanced optical and MR imaging can allow determination of @entity5 margins at the optimal time of 15-120 minutes after administration of @entity32736 . Clinical application of these results may @entity11 in a hybrid surgical setting in which intraoperative optical and MR imaging are available. (  ) RSNA, 2015.
