Analysis of the relationship between microsatellite instability and XXXX induced by @entity7044 in C57BL/6J @entity19 .

@entity1 @entity7045 @entity124 @entity706 @entity5 @entity19 @entity3733 @entity6732 @entity7044
@entity124 ( @entity124 ) has been found to be closely associated with many types of @entity1 @entity5 and often shows strong correlations with specific @entity5 features. However, the relationship between @entity124 and @entity5 are still unclear. The aim of the present study is to explore the relationships between @entity124 , @entity5 formation under the mutagenic effects of @entity7044 ( @entity7045 ). @entity19 were administered with either @entity7045 (90mg/kg) or PBS and @entity3733 (control) at the beginning of the 1st week of the experiment. Of the 31 @entity19 that survived the entire experimental time course, 19 (61.3%) @entity19 developed @entity6732 . In addition, 52.6% (10/19) of the @entity5 had metastasized to the liver. We detected @entity124 in @entity7045 -treated @entity19 using a panel of 42 mutation-sensitive loci. Nineteen loci (45.2%) in six organs showed 70 @entity124 events. Locus D8Mit14 showed enhanced @entity124 compared with the other examined loci. @entity124 frequency in thymus was higher than in other organs. Interestingly, there was no significant difference observed between the metastatic and non-metastatic livers. The @entity124 frequency (4.6%, 23/(42*12)) in the @entity7045 -treated thymus that had never developed @entity5 was significantly higher than this in the thymus that had developed @entity706 (0.5%, 4/(42*19)) (p<0.0001). These results indicate that, although thymic tumorigenesis is associated with @entity124 , it occurs with higher frequency in these that have not developed @entity5 upon the @entity7045 -treatment. Our study provides additional insights into the relationship between @entity124 occurrence and tumorigenesis.
