Neuropathologically mixed XXXX : burden of pathological @entity6960 differs between clinical phenotypes.

@entity1 @entity8095 @entity303 @entity4306 @entity191 @entity1832 @entity6960 @entity195
UNASSIGNED: Multiple different pathological @entity6960 are frequently seen in @entity1 postmortem brains and hence mixed pathology is common. Mixed @entity303 on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured the amount of hyperphosphorylated microtubule associated tau ( @entity4306 -  ), amyloid-b protein (Ab) and @entity8095 ( @entity8095 ) in cases that were neuropathologically diagnosed as mixed @entity195 ( @entity195 ) and neocortical @entity1832 ( @entity1832 ) but clinically presented either as @entity303 due to @entity195 or @entity1832 , the latter including @entity1832 ( @entity1832 ) and @entity191 ( @entity191 ). Our study group consisted of 28 cases (mean age, 76.11 SE:   1.29 years; m:f, 17:11) of which 19 were neuropathologically diagnosed as mixed @entity195 / @entity1832 . Clinically, 8 mixed @entity195 / @entity1832 cases were diagnosed as @entity195 (cAD), 8 as @entity1832 (cDLB) and 3 as @entity191 (cPDD). In addition, we investigated cases that were both clinically and neuropathologically diagnosed as either @entity195 (pure @entity195 ; n  =  5) or @entity1832 /neocortical @entity1832 (pure @entity1832 ; n  =  4). Sections from neocortical, limbic and subcortical areas were stained with antibodies against @entity4306 -  , Ab and @entity8095 . The area covered by immunopositivity was measured using image analysis. cAD cases had higher @entity4306 -   loads than both cDLB and cPDD and the distribution of @entity4306 -   in cAD was similar to the one observed in pure @entity195 whilst cDLB showed comparatively less hippocampal @entity4306 -   load. cPDD cases showed lower @entity4306 -   and Ab loads and higher @entity8095 loads. Here, we show that in neuropathologically mixed @entity195 / @entity1832 cases both the amount and the topographical distribution of pathological @entity6960 differed between distinct clinical phenotypes. Large-scale clinicopathological correlative studies using a quantitative methodology are warranted to further elucidate the neuropathological correlate of clinical symptoms in cases with mixed pathology.
