Effects of dietary fat on virus-induced XXXX in guinea fowl.

@entity788 @entity5 @entity5072 @entity4336 @entity660 @entity1157 @entity245 @entity189 @entity1017
The present study was performed to assess the effects of diets supplemented with low (5%) and high (20%) @entity4336 oil on a Pts 56 retrovirus-induced model of @entity788 in guinea fowl. The early microscopic lesions appear after 3 mo after virus treatment and progress over time. Eight to 10 mo after initiation, up to 100% of virus-inoculated birds develop multiple @entity5072 and neoplastic @entity660 of duct/ductular phenotype. Short-term (1-4 mo) feeding of low- or high-fat diets, beginning at Month 3, had no significant effects on body and pancreatic weight. However, the incidence, multiplicity, and areas of the pancreatic tissue occupied by intra- and interlobular aggregates of @entity1157 with mucinous metaplasia of the lining cells were significantly increased compared with the birds fed the common diet. At the same time, @entity245 , particularly @entity189 , was retarded compared with the common diet-fed controls. Long-term (5-7 mo) fat intake resulted in an increase in body @entity1017 , while absolute pancreatic weights remained relatively constant. Furthermore, the high- and low-fat diets caused a significant increase in areas of retrovirus-induced @entity660 , as well as an increase in @entity5 compared with short-term fat feeding. It is concluded that short-term feeding of diets supplemented with 5% or 20% @entity4336 oil delayed the development of the common virus-induced ductular @entity5 , particularly @entity189 , and had an enhancing effect on development of @entity5072 inter- and intralobular aggregates of ducts. This finding was not observed, however, during the long-term feeding period of the study.
