Altered functional connectivity in lesional peduncular @entity146 with XXXX @entity146 .

@entity1 @entity1949 @entity146 @entity75 @entity1833 @entity955 @entity25 @entity385
@entity75 causing peduncular @entity146 (PH) produce vivid @entity1833 occasionally accompanied by @entity25 . Overlapping brainstem regions modulate visual pathways and @entity1949 sleep functions via gating of thalamocortical networks. A 66-year-old @entity1 with paroxysmal @entity955 developed @entity1833 with preserved insight and violent dream enactment behavior. Brain MRI showed restricted diffusion in the left rostrodorsal pons suggestive of an acute @entity385 . @entity1949 @entity146 (RBD) was diagnosed on polysomnography. We investigated the integrity of ponto-geniculate-occipital circuits with seed-based resting-state functional connectivity MRI (rs-fcMRI) in this @entity1 compared to 46 controls. Rs-fcMRI revealed significantly reduced functional connectivity between the lesion and lateral geniculate nuclei (LGN), and between LGN and visual association cortex compared to controls. Conversely, functional connectivity between brainstem and visual association cortex, and between visual association cortex and prefrontal cortex (PFC) was significantly increased in the @entity1 . Focal damage to the rostrodorsal pons is sufficient to cause RBD and PH in @entity1 , suggesting an overlapping mechanism in both syndromes. This lesion produced a pattern of altered functional connectivity consistent with disrupted visual cortex connectivity via de-afferentation of thalamocortical pathways.
