Disease activity and XXXX uptake in @entity55 : semi-quantitative evaluation using computed tomography and positron emission tomography.

@entity1 @entity405 @entity419 @entity55
PURPOSE: The present study was conducted to evaluate whether @entity419 positron emission tomography (FDG-PET) in combination with computed tomography (CT) reflects disease activity in @entity1 with @entity55 . METHODS: Eighty-eight subjects who were normal (n=66) or who had proven @entity55 (n=22) underwent FDG-PET and CT imaging. The subjects included 55 @entity1 and 33 @entity1 , ranging in age from 24 to 63 years (mean 47 years). PET and CT data sets were digitally fused using a conformational PET/CT fusion algorithm. All scans were evaluated independently by two chest radiologists who were unaware of other clinical data. The visual score, maximal and mean standardised uptake value (SUV), and maximal and mean lesion-to-normal tissue ratio (LNR) were calculated. The imaging results were compared with the laboratory and pulmonary function test results. The inflammatory cells in the lesions were quantified immunohistochemically. RESULTS: The visual score, maximal and mean SUV, and maximal and mean LNR of the @entity1 with @entity55 were significantly higher than those of the normal subjects. The @entity1 with air-space consolidation had a significantly higher SUV than those without air-space consolidation (mean+/-SD 3.08+/-0.39 vs 2.35+/-0.56; p<0.05). The number of CD45(+) cells was positively correlated with the maximal SUV (r=0.632, p<0.01) and the maximal LNR (r=0.453, p<0.05). The number of @entity405 (+) T lymphocytes also showed positive correlations with the maximal SUV (r=0.540, p<0.01) and the maximal LNR (r=0.547, p<0.01). CONCLUSION: @entity1 with @entity55 have an enhanced FDG accumulation which reflects the degree of disease activity.
