Pre-ischemic exercise reduces apoptosis in hippocampal @entity1251 cells after cerebral ischemia by modulation of the @entity2310 / @entity1976 proteins ratio and prevention of XXXX activation.

@entity1976 @entity63 @entity2310 @entity1251 @entity35 @entity4124
UNASSIGNED: @entity63 induces physiological alterations in neurons that lead to cell death. This study investigated the effects of pre-ischemic exercise on @entity1251 neurons. @entity35 were divided into three groups. Animals in the exercise group were trained 5  days a week for 4  weeks. @entity63 was induced by occlusion of both common carotid arteries (CCAs) for 20  min. Apoptotic cell death was detected by TUNEL assay. Furthermore, expression of different proteins was determined by immunohistochemical staining. The number of TUNEL-positive cells was significantly increased in the @entity63 group, but pre-ischemic exercise significantly reduced apoptotic cell death (P  <  0.001). In addition, our results showed a significant increase in the @entity2310 / @entity1976 ratio in the @entity63 group. Pre-ischemic exercise attenuated this ratio (P  <  0.05). Furthermore, the number of active @entity4124 -positive neurons was significantly increased in the @entity63 group, which was reduced markedly by exercise preconditioning (P  <  0.05). This study showed that pre-ischemic exercise can exert neuroprotective effects against @entity63 in @entity1251 neurons.
