Evaluation of resorbable barriers for preventing surgical XXXX .

@entity35 @entity1104 @entity5224 @entity4023
OBJECTIVE: To evaluate the ability of collagen film, collagen gel, @entity4023 / @entity5224 film, and fibrin glue to prevent @entity1104 formation. DESIGN: Randomized trial using a @entity35 model of a standardized abdominal wound and cecal wound. SETTING: University research laboratory. ANIMAL(S): Sprague-Dawley female @entity35 . INTERVENTION(S): Resorbable barriers or no barrier (controls) were placed between an abdominal wall wound (1 cm x 2 cm) and a similarly sized cecal wound. MAIN OUTCOME MEASURE(S): Adhesion formation between wounds was assessed and quantitated 7 days after surgery. RESULT(S): Without treatment, 34 of 35 untreated @entity35 (97%) developed @entity1104 . Treatment with collagen gel (3 of 33 @entity35 ), collagen film (3 of 10 @entity35 ), or @entity4023 / @entity5224 film (2 of 10 @entity35 ) significantly reduced the incidence of @entity1104 formation. Treatment with fibrin sealant resulted in 9 of 10 animals having adherent wounds 7 days after surgery. CONCLUSION(S): Resorbable barriers of collagen gel, collagen films and @entity4023 / @entity5224 film were effective in significantly reducing @entity1104 formation. Fibrin sealant at 7 days had an incidence of @entity1104 formation similar to that in untreated control animals.
