[A possible mechanism of XXXX during interferon therapy with sho-saiko-to].

@entity1 @entity3335 @entity1356 @entity310 @entity26 @entity3794 @entity401
@entity401 has been reported to be a side effect of treatment with interferon, and Sho-saiko-to (Xiao-Chai-Hu-Tang) may enhance this side effect. It is well known that activated neutrophils are important mediators of @entity3794 , so we studied the effects of interferon and Sho-saiko-to on neutrophil activation. Homogenized lung @entity3335 ( @entity3335 ) activity was assayed after intraperitoneal injection of interferon with or without pretreatment with Sho-saiko-to. Although Sho-saiko-to alone did not change the lung @entity3335 content, @entity3335 in the lung was significantly increased by interferon administration. The increase was enhanced further by pretreatment with Sho-saiko-to. When the accumulated neutrophils are activated by some cytokines, such as @entity310 or @entity1356 from monocytes/macrophages, they may damage lung tissue. We therefore studied the effects of Sho-saiko-to and interferon on @entity310 production in freshly isolated @entity1 monocytes. Sho-saiko-to increased the production of @entity310 , but interferon did not. In addition, Sho-saiko-to significantly increased the production of @entity310 by monocytes stimulated by lipopolysaccharide. Taken together, these data indicate that interferon causes neutrophils to accumulate in the lung. Sho-saiko-to alone may not injure lung tissue, but it increases the effect of interferon. When stimulated by some antigen, Sho-saiko-to may overstimulate the neutrophils. Granulocytes elastase and @entity26 radicals released from activated neutrophils may damage lung tissue. The fibroblasts that repair the damaged tissue may increase the risk of @entity3794 .
