Suppression of Proinflammatory and Prosurvival Biomarkers in @entity5 XXXX Consuming a Black Raspberry Phytochemical-Rich Troche.

@entity1 @entity71534 @entity137 @entity2451 @entity5 @entity23249 @entity957 @entity470 @entity3840 @entity875 @entity71533 @entity105
UNASSIGNED: Black raspberries (BRB) demonstrate potent inhibition of aerodigestive tract @entity105 in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for @entity5 food-based prevention: Do BRB phytochemicals successfully reach the targeted oral tissues and reduce proinflammatory and antiapoptotic gene expression profiles? @entity1 with biopsy-confirmed @entity957 ( @entity957 ) administered oral troches containing freeze-dried BRB powder from the time of enrollment to the date of curative intent surgery (13.9    1.27 days). Transcriptional biomarkers were evaluated in @entity1 -matched OSCCs and noninvolved high at-risk mucosa (HARM) for BRB-associated changes. Significant expression differences between baseline @entity957 and HARM tissues were confirmed using a panel of genes commonly deregulated during oral @entity105 . Following BRB troche administration, the expression of prosurvival genes ( @entity875 , @entity23249 , @entity470 ) and proinflammatory genes ( @entity2451 , @entity3840 ) were significantly reduced. There were no BRB-associated grade 3-4 @entity137 or adverse events, and 79.2% (N = 30) of @entity1 successfully completed the study with high levels of compliance (97.2%). The BRB phytochemicals @entity71533 and @entity71534 were detected in all @entity957 tissues analyzed, demonstrating that bioactive components were successfully reaching targeted @entity957 tissues. We confirmed that hallmark antiapoptotic and proinflammatory molecular biomarkers were overexpressed in OSCCs and that their gene expression was significantly reduced following BRB troche administration. As these molecular biomarkers are fundamental to oral @entity105 and are modifiable, they may represent emerging biomarkers of molecular efficacy for BRB-mediated @entity5 chemoprevention. Cancer Prev Res; 9(2); 1-13.   2015 AACR.
