Re-Assessing Non-Inducibility as Ablation Endpoint of Post-Infarction XXXX : The Impact of Left Ventricular Function.

@entity1 @entity583 @entity204 @entity1165
BACKGROUND: -Non-inducibility is frequently used as procedural endpoint of @entity1165 ( @entity1165 ) ablation after @entity583 ( @entity583 ). We investigated the influence of left ventricular (LV) function on the predictive value of non-inducibility for @entity1165 recurrence and cardiac mortality. METHODS AND RESULTS: -Ninety-one @entity1 (82 @entity1 , 67  10 years) with @entity583 @entity1165 underwent ablation between 2009 and 2012. Fifty-nine (65%) had a LV ejection fraction (EF) >30%, (mean 41  7) and 32 (35%) a LVEF <=30% (mean 20  5). Thirty @entity1 (51%) with EF>30% and 13 (41%) with EF <=30% were non-inducible after ablation (P=0.386). During a median follow-up of 23 (Q1-Q3 16-36) months, 35 @entity1 (38%) experienced @entity1165 recurrences and 17 (18%) @entity204 . At one year follow-up, survival free from @entity1165 recurrence and @entity204 for @entity1 with LVEF>30% was 80% (CI 95%, 70-90) compared to 42% (CI 95%, 33-51) for those with LVEF <=30% (P=0.001). Non-inducible @entity1 with LVEF>30% had a recurrence-free survival from @entity204 of 90% (CI 95%, 71-100) compared to 65% (CI 95% 47-83) for inducible @entity1 (P= 0.015). In the subgroup of @entity1 with LVEF <=30% the survival free from @entity1165 recurrence and @entity204 was 31% (CI 95%, 0-60%) for non-inducible compared to 39% (CI 95%, 27-52) for those who remained inducible (P= 0.842). CONCLUSIONS: -Non-inducible @entity1 with moderately depressed LV function have a favorable outcome compared to @entity1 that remained inducible after ablation. On the contrary, @entity1 with severely depressed LV function have a poor prognosis independent of the acute procedural outcome.
