Comparison of XXXX and @entity205 in @entity5396 expressing Chinese de novo kidney transplant recipients: a 2-year prospective study.

@entity1 @entity9472 @entity5469 @entity8999 @entity5396 @entity5466 @entity205 @entity1140
AIMS: To assess the efficacy and safety of @entity1140 and @entity205 ( @entity9472 )-based immunosuppressive regimens in Chinese de novo kidney transplant recipients who are @entity5396 expressers. METHODS: The @entity5396 ( @entity5466 , @entity5469 ) polymorphism of eligible @entity1 was determined before transplantation. De novo kidney transplant recipients enrolled in this study were assigned to @entity1140 (Tac group) or @entity9472 ( @entity9472 group) based therapy. The follow-up period was 2  years. The incidence of acute rejection, @entity1 and graft survival rates, renal allograft function and post-transplant complications were compared. The intra-individual variability (IIV) of Tac and @entity9472 blood concentrations was analysed. Medication costs were also compared. The analysis was conducted on the intention-to-treat principle. RESULTS: A total of 72 @entity5396 expressers were enrolled, with 36 @entity1 in each group. AR incidence was higher in the Tac group (11.1% vs. 5.6%), but there was no significant difference (p  >  0.05). The 2-year @entity1 and graft survival was comparable, and renal function was comparable in the two groups. Notably, the Tac group presented a significantly higher incidence of BK viremia (22.2% vs. 5.6%, p  <  0.05) and BK viruria (38.9% vs. 16.7%, p  <  0.05) than the @entity9472 group. The @entity9472 IIV at 1 and 3  months post-transplant was significantly lower than the Tac IIV (p  <  0.05). The medical costs of both immunosuppressive drugs and management of complications was significantly lower in the @entity9472 group. CONCLUSIONS: @entity205 -based maintenance therapy is safe for Chinese de novo kidney transplant recipients who are @entity5396 expressers. @entity9472 significantly reduced medication costs and decreased @entity8999 infection, suggesting that it is more beneficial for this specific population.
