Bacteria and granulation tissue associated with XXXX .

@entity1 @entity796 @entity115 @entity794 @entity2348 @entity798 @entity281 @entity1346 @entity5274 @entity800
OBJECTIVES: Although complications ( @entity281 , development of granulation tissue) of @entity1346 @entity5274 have been reported, the microbiological consequences and the origin of granulation tissue have not yet been evaluated. STUDY DESIGN: A prospective trial. METHODS: Twenty-three @entity5274 from 10 @entity1 were analyzed with regard to the development of granulation tissue, bacterial growth (including genotyping with polymerase chain reaction), and results of sensitivity testing. Furthermore, stent sterilization (n = 6) was investigated. RESULTS: Granulation tissue occurred with 74% of the stents, and all specimens showed signs of @entity281 but no foreign body reaction. The predominant organisms were @entity794 (35%) and @entity796 (17%). The differences between groups with and without granulation tissue were significant for @entity796 . Polymerase chain reaction fingerprinting of the @entity794 obtained from 15 stents (n = 3 @entity1 ) revealed a total of seven different genotypes. Whereas two of these @entity1 harbored six different genotypes of @entity794 , the third @entity1 was persistently colonized by @entity794 over a 15-month period with the identical genotype. Susceptibility testing showed most commonly (65%) sensitivity to a combination of @entity115 - @entity798 and @entity800 . After sterilization, 92% of analyzed stent segments showed no bacterial growth. CONCLUSIONS: Granulation tissue commonly occurred next to the @entity1346 (subglottic area, stoma) where @entity794 and @entity796 were commonly isolated. A combination of mechanical irritation and @entity2348 seems to account for the development of granulation tissue. Polymerase chain reaction fingerprinting showed both prolonged persistence and a change of colonizing strains after multiple stent replacements. A combination of @entity115 - @entity798 and @entity800 is the most effective antibiotic therapy. Sterilization of the cost-intensive @entity1346 stents is feasible, and reuse in the same @entity1 is justifiable from economic aspects.
