Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed XXXX .

@entity1707 @entity295 @entity5694 @entity294
OBJECTIVE: To determine the effects of hyperdynamic @entity5694 on the motility of the small intestine. SUMMARY BACKGROUND DATA: Motility disorders of the gastrointestinal tract are a common complication of @entity295 . It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying @entity294 frequently observed. METHODS: @entity1707 were infused with lipopolysaccharide for a 24-hour period. During this fasting period jejunal motility was measured using ambulatory manometry. One and 4 days after cessation of endotoxin, @entity1707 were enterally fed, and again motility was recorded. RESULTS: @entity5694 was achieved in this model. Manometric pressure recordings revealed that endotoxin infusion accelerated the migrating motor complex (MMC) migration along the jejunum. Also, a simultaneous increase in MMC cycling frequency was observed in the endotoxin-treated group. Elevated MMC migration velocity and cycling frequency were maintained the following day after endotoxin during feeding and returned to basal values 4 days after endotoxin. CONCLUSIONS: A small dose of continuously infused endotoxin significantly provokes jejunal motility disturbances that may contribute to @entity294 .
