Correlation between invasive pattern and immunophenotypic alterations in XXXX .

@entity1712 @entity986 @entity5 @entity5962 @entity4910 @entity189 @entity3546 @entity2277 @entity5822 @entity420
AIMS: To assess the immunophenotypic changes associated with epithelial-mesenchymal transition (EMT) in @entity420 , and correlate the findings with @entity5 morphology including growth pattern. METHODS AND RESULTS: Twenty-seven endocervical @entity420 were studied using a panel of immunohistochemical markers to @entity2277 , @entity4910 , @entity5962 , @entity3546 , @entity986 protein and @entity5822 . There were 24 moderately differentiated and three poorly differentiated @entity5 . Fourteen of the moderately differentiated @entity189 showed a focal infiltrative component, typically towards the deep @entity5 margin (invasive front), comprising attenuated glands, small cell clusters and single cells. These foci typically showed cytological alteration including loss of cellular polarity and cytoplasmic @entity1712 , while immunohistochemistry demonstrated reduced cell membrane @entity5962 and beta catenin labelling, and expression of @entity4910 and, in some cases, @entity2277 . Similar immunophenotypic changes were focally observed at the deep aspect of some larger 'conventional' @entity5 glands. No consistent changes were observed in the poorly differentiated @entity189 . CONCLUSIONS: Endocervical @entity420 that demonstrate an infiltrative growth pattern show immunophenotypic changes consistent with EMT. Frequently, these are accompanied by a morphological alteration in the @entity5 cells and the changes exhibit a specific micro-anatomical distribution. Epithelial-mesenchymal transition may represent an important mechanism in the progression of some endocervical @entity5 .
