XXXX of @entity5 : a clinicopathologic spectrum.

@entity1 @entity82 @entity39 @entity5 @entity4 @entity358 @entity230
We described five @entity1 in whom pulmonary @entity5 was histologically confirmed during life. Pulmonary symptoms dominated the clinical presentation in three @entity1 , and one @entity1 had a 5-year history of pulmonary @entity5 controlled by @entity230 . Radiologic features were nonspecific. Most @entity1 had bilateral reticulonodular or fluffy infiltrates. Recurrent @entity358 in one @entity1 was manifest by bilateral pulmonary nodules. Pathologically, @entity358 by @entity5 followed the normal lymphatic pathways of the lung along bronchovascular rays, in interlobular septa, and within the pleura. Unusual features included marked @entity4 and @entity82 out of proportion to the degree of infiltration, and in one case, the marked predilection fo the infiltrate to occlude small airways (" @entity5 "). Three @entity1 had microscopic nondestructive nodules adjacent to lymphatics. A pulmonary recurrent in one @entity1 was composed of large monomorphous nodules with central @entity39 and prominent vascular infiltration by malignant cells. The pulmonary infiltrate of @entity5 was often heterogeneous, and included variable numbers of lymphocytes and plasma cells intermingled with alveolar macrophages and metaplastic alveolar lining cells. The cytologic features of the infiltrate varied from benign to pleomorphic and obviously malignant. Histologic features which may obscure the correct diagnosis, as they did initially in three of our cases, include: malignant histiocytic bronchiolitis, marked @entity4 and @entity82 ; the heterogeneous cellular infiltrate; and in one case, benign cytologic features. The most valuable initial clue to the correct diagnosis was the tendency of the infiltrates to follow lymphatics of the lung.
