@entity1748 -Related Protein-1 ( XXXX ) Regulates @entity165 Accumulation in Macrophages.

@entity1748 @entity19 @entity412 @entity20663 @entity731 @entity8557 @entity165
UNASSIGNED: Within the circulation, @entity165 is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors. In macrophages, excessive lipoprotein particle uptake leads to foam cell formation, which is an early event in the development of @entity731 . Currently, mechanisms responsible for foam cell formation are incompletely understood. To date, several macrophage receptors have been identified that contribute to the uptake of modified forms of lipoproteins leading to foam cell formation, but the contribution of the @entity20663 ( @entity20663 ) to this process is not known. To investigate the role of @entity20663 in @entity165 accumulation in macrophages, we generated @entity19 with a selective deletion of @entity20663 in macrophages on an @entity1748 ( @entity1748 )-deficient background (macLRP1-/-). After feeding @entity19 a high fat diet for 11 weeks, peritoneal macrophages isolated from @entity20663 +/+ @entity19 contained significantly higher levels of total @entity165 than those from macLRP1-/- @entity19 . Further analysis revealed that this was due to increased levels of @entity8557 . Interestingly, macLRP1-/- @entity19 displayed elevated plasma @entity165 and @entity412 levels resulting from accumulation of large, @entity412 -rich lipoprotein particles in the circulation. This increase did not result from an increase in hepatic VLDL biosynthesis, but rather results from a defect in catabolism of @entity412 -rich lipoprotein particles in macLRP1-/- @entity19 . These studies reveal an important in vivo contribution of macrophage @entity20663 to @entity165 homeostasis.
