Examination of the potential association of stress with morbidity and mortality outcomes in XXXX with @entity712 .

@entity1 @entity712 @entity701
OBJECTIVES: The high mortality and morbidity rates associated with @entity712 are still not well explained. A few psychosocial factors have been studied and explain some of this risk, but other factors, like stress, remain largely unexplored in @entity712 . This study aimed to (1) examine the association of stress with 6-month cardiac event-free survival, (2) examine the relationship of stress with salivary @entity701 , and (3) examine the association of salivary @entity701 level with 6-month cardiac event-free survival. METHOD: A total of 81 @entity712 @entity1 participated. Stress was measured using the brief Perceived Stress Scale. @entity701 was measured from unstimulated whole expectorated saliva. Cox regression analyses were used to determine whether stress predicted event-free survival, and if salivary @entity701 predicted event-free survival. Linear and multiple regressions were used to determine the association of stress with salivary @entity701 . RESULTS: Stress was not a significant predictor of event-free survival in @entity712 (heart rate = 1.06; 95% confidence interval = 0.95-1.81; p = 0.32). Salivary @entity701 was a significant predictor of event-free survival in the unadjusted model (heart rate = 2.30; 95% confidence interval = 0.99-5.927; p = 0.05), but not in the adjusted model. Stress (b 1.06; 95% confidence interval = 0.95-1.18; p = 0.32) was not a significant predictor of salivary @entity701 level. CONCLUSION: Stress is a complex phenomenon, and our measure of stress may not have captured it well. Alternatively, the physical stressors acting in @entity712 produce levels of neurohormonal activation that mask the effects of psychosocial stressors or an indirect association of stress with outcomes that is mediated through another construct. Future studies are needed to investigate stress in @entity1 with @entity712 to provide definitive answers.
