Responses of dural mast cells in concussive and blast models of mild @entity131 in XXXX : Potential implications for post-traumatic @entity10 .

@entity1 @entity131 @entity19 @entity542 @entity1372 @entity450 @entity9251 @entity10 @entity130
BACKGROUND: Chronic post-traumatic @entity10 (PTH) is one of the most common symptoms of mild @entity131 (mTBI) but its underlying mechanisms remain unknown. Inflammatory degranulation of dural mast cells (MCs) is thought to promote @entity10 , and may play a role in PTH. Whether mTBI is associated with persistent degranulation of dural MCs is yet to be determined. METHODS: Histochemistry was used to evaluate time course changes in dural MC density and degranulation level in concussive @entity542 and blast @entity19 models of mTBI. The effects of @entity9251 and the MC stabilizer cromolyn @entity1372 on concussion-evoked dural MC degranulation were also investigated. RESULTS: Concussive @entity542 evoked persistent MC degranulation for at least 30 days. Blast @entity130 gave rise to a delayed MC degranulation response commencing at seven days that also persisted for at least 30 days. Neither @entity9251 nor cromolyn treatment reduced concussion-evoked persistent MC degranulation. CONCLUSIONS: mTBI evoked by closed @entity542 or blast exposure is associated with persistent dural MC degranulation. Such a response in mTBI @entity1 may contribute to PTH. Amelioration of PTH by @entity9251 may not involve @entity450 . If persistent dural MC degranulation contributes to PTH, then cromolyn treatment may not be effective.
