Preparation of anesthesia machines for XXXX susceptible to malignant hyperthermia.

@entity1 @entity5161 @entity590 @entity1508
@entity590 is a potentially lethal syndrome that can be triggered by inhaled anesthetics. Thus, it may be appropriate to utilize equipment that minimizes exposure of susceptible @entity1 to inhaled anesthetics. The rate of release of anesthetic stored in anesthesia delivery systems is unknown. To determine residual anesthetic concentrations, the washout rates of @entity1508 and @entity5161 were compared, and the effects of a 1-l/min and a 10-l/min fresh gas flow were evaluated. @entity1508 concentrations were also measured in samples taken from the fresh gas outlet and the Y-piece of the circle system during four separate studies in which various components of the anesthesia system were replaced. In each study an Ohio Modulus anesthesia machine equipped with an Air-Shields ventilator was exposed to 2% @entity1508 for 18 h. Anesthetic concentrations were determined by a gas chromatograph having a sensitivity of 0.1 ppm. @entity5161 washed out 3-4 times faster than @entity1508 . Residual @entity1508 concentration was approximately equal to tenfold greater when the fresh gas flow was 1 l/min rather than 10 l/min: 194 versus 19 ppm after 1 h of washout. Using a 10-l/min fresh gas flow, @entity1508 concentrations in samples obtained from the Y-piece were similar with original or fresh soda lime but were more than tenfold lower after the fresh gas outlet hose and circle system were replaced (approximately equal to 50 ppm vs. approximately equal to 5 ppm after 5 min of washout).(ABSTRACT TRUNCATED AT 250 WORDS)
