Influence of reproductive history on age at diagnosis of XXXX and prognosis.

@entity1 @entity0
The effect on age at @entity0 diagnosis of age at menarche, age at first baby, parity and age at menopause has been determined for 739 unselected @entity1 diagnosed between 1975 and 1980 as having operable @entity0 . Age at diagnosis was significantly and positively associated with ages at menarche, first baby and menopause. The average number of @entity1 significantly declined with increasing age at diagnosis. This was largely due to a change in the proportion of @entity1 who were nulliparous (15% in @entity1 aged 41-50 years compared to about 30% in those over 60 years). A group of 1,989 normal @entity1 whose reproductive history was also collected between 1975 and 1980 showed similar trends between age and age at menarche, age at first baby and parity as the @entity1 . Thus it appears that these reproductive parameters do not alter the time of onset of @entity0 but could be explained by temporal changes in reproductive patterns. There was no significant correlation between age at menopause and age at diagnosis for @entity1 whose age at menopause was no more than 54 years and age at diagnosis no less than 55 years, respectively. It is therefore unlikely that age at menopause affects age at diagnosis. Postmenopausal @entity1 with 3 or more @entity1 had a significantly shorter disease-free interval and lower survival rate than those with less @entity1 . None of the other parameters was associated with prognosis.
