[Experimental XXXX of ductal origin. Anatomo-pathologic and ultrastructural study].

@entity1 @entity788 @entity39 @entity235 @entity4 @entity3645
The injection of bile under low pressure led in 21 @entity235 out of 30 to a process of acute @entity788 and to the reproduction of the different histopathological types of @entity788 seen in @entity1 . This represents a weighty argument in favour of the concept of @entity788 , @entity788 with sometimes major cytosteatonecrosis and necrosing @entity788 as different manifestations of the same disease, which is not universally accepted. Our research has once again emphasized the fact that the interstitial phenomena and in @entity39 precede @entity39 . Morphological studies were used to attempt to define the link between fat @entity39 and acinar @entity39 . Light microscopy showed that there was no topographic evidence of direct involvement of the acinar cell in contact with fat @entity39 . By contrast, ultrastructural studies revealed initial involvement of the basal pole of the acinar cell. This would emphasize the responsibility of interstitial phenomena in the maintenance, if not the induction, of acinar @entity39 . It cannot be excluded that fat @entity39 could indirectly, via the liberation of factors carried by @entity4 , play a role in these phenomena of acinar @entity39 . In addition, it was noted that the apical poles of the acinar cells did not seem to be damaged, the acinar lumina were dilated and there was loss of the intercellular junctions. This would hence indicate the possible passage into the interstitium of a toxic substance ( @entity3645 , enzymes liberated in excess) coming directly from the acinar lumina.
