XXXX Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study.

@entity1 @entity2520 @entity309 @entity2521
BACKGROUND: The risk of @entity2521 ( @entity2521 ) is increased in the @entity1 group of @entity309 ( @entity309 ). @entity309 and @entity2521 also shared some pathological mechanism. The aim of this study is to investigate the risk of @entity309 associated with @entity2521 exposure. METHODS AND FINDINGS: This study identified 3 mutually exclusive cohorts using the 1999-2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between @entity2521 and the risk of incident @entity309 . All @entity1 with @entity2521 in 2000 were identified from the database of all enrollees as the @entity2521 cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any @entity2520 ( @entity2520 ) during 1999-2010 were selected as the non- @entity2520 cohort. Individuals who were not included in the non- @entity2520 cohort and received dental scaling (DS) no more than two times per year during 1999-2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between @entity2521 exposure and @entity309 development. In the three-group comparison using the non- @entity2520 cohort as reference, we found that the risk of @entity309 was higher in the @entity2521 and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively). For comparisons between two cohorts, the @entity2521 cohort had a higher risk of @entity309 than the non- @entity2520 and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively). CONCLUSION: @entity2521 was associated with an increased risk of @entity309 development.
