Placental pathology in XXXX .

@entity1 @entity64 @entity5028 @entity715 @entity385
OBJECTIVE: @entity64 is increasingly recognized, and risk factors have been identified. The placenta has been implicated as a potential contributor to @entity64 ; however, pathology has not been previously described. This case series systematically evaluates prenatal, maternal, and neonatal risk factors and describes placental pathology in 12 cases of @entity64 . @entity1 AND METHODS: We reviewed the Canadian @entity385 Registry from 1992 to 2006, which consists of 186 @entity64 @entity1 . Twelve @entity1 with symptomatic cerebral arterial @entity385 or sinovenous @entity715 had their placenta available for pathologic examination. Clinical presentation; maternal, prenatal, and neonatal risk factors for @entity64 ; and @entity1 outcome were collected retrospectively from @entity1 charts. Gross and microscopic placental pathology was described and classified into 4 pathologic categories. RESULTS: Of 12 @entity1 studied, 10 @entity1 were male, 5 @entity1 had arterial @entity385 , and 7 @entity1 had sinovenous @entity715 . Maternal risk factors were identified in 5 cases, prenatal risk factors in 10 cases, and neonatal risk factors in 10 cases. Placental lesions were present in 10 cases and were classified as thromboinflammatory process in 6 cases, sudden catastrophic event in 5 cases, decreased placental reserve in 3 cases, and stressful intrauterine environment in 2 cases. CONCLUSIONS: This study reviews detailed placental pathology in a selected cohort of @entity1 presenting near the time of delivery and correlates this with clinical presentation, outcome, and risk factors for @entity64 . Our results suggest that multiple risk factors are involved in @entity64 , and placental pathology may be a contributing factor. The implications of specific @entity5028 remain to be determined with larger, case-controlled studies.
