Decline in functional performance predicts later increased XXXX and mortality in @entity3657 .

@entity1 @entity393 @entity65 @entity3657
OBJECTIVES: We hypothesized that a greater 2-year decline in office-based functional performance measures would be associated with greater @entity393 and mortality in @entity1 with @entity3657 ( @entity3657 ). BACKGROUND: Associations of decline in functional performance with clinically important outcomes in @entity1 with @entity3657 are unknown. METHODS: A total of 440 @entity1 and @entity1 with @entity3657 completed the 6-min walk test and measures of walking velocity at baseline and annually for 2 years. @entity1 were categorized into tertiles according to their functional decline between baseline and 2-year follow-up and were followed annually after the functional change assessment. Cox proportional hazard models were used to assess relations between the 2-year change in functional performance with later mortality and @entity393 , with adjustments for age, sex, race, ankle brachial index, comorbidities, and other confounders. RESULTS: A total of 102 @entity1 (23.2%) died during a median follow-up of 44.5 months after functional change was assessed. Of 319 @entity1 without baseline mobility disability, 60 (18.8%) developed @entity393 after functional change was assessed. @entity1 in the tertile with the greatest 6-min walk decline had the highest subsequent @entity393 (hazard ratio [HR]: 3.50; 95% confidence interval [CI]: 1.56 to 7.85; p = 0.002), all-cause mortality (HR: 2.16; 95% CI: 1.28 to 3.64; p = 0.004), and @entity65 mortality (HR: 2.45; 95% CI: 1.08 to 5.54; p = 0.031), compared with those with the smallest 6-min walk decline. Greater declines in fastest-paced 4-m walking velocity were associated with higher @entity393 (p trend = 0.018), all-cause mortality (p trend = 0.01), and @entity65 (p trend = 0.004). CONCLUSIONS: @entity1 with @entity3657 with declining functional performance are at increased risk for later @entity393 and mortality.
