Long-term subjective cognitive functioning following adjuvant systemic treatment: 7-9 years follow-up of a nationwide cohort of XXXX treated for primary @entity0 .

@entity1 @entity73 @entity0
BACKGROUND: There is growing concern among @entity0 ( @entity0 ) @entity1 and survivors about @entity73 following systemic treatments. The aim of the present study was to investigate the long-term effects of standard systemic adjuvant therapies on @entity73 ( @entity73 ) in a large nationwide cohort of @entity0 survivors 7-9 years after primary surgery. METHODS: @entity1 were recruited from the nationwide Psychosocial Factors and @entity0 inception cohort of Danish @entity1 treated for primary @entity0 . @entity73 was assessed with the Cognitive Failures Questionnaire and @entity1 allocated to systemic treatment according to nationwide standard protocols were compared with @entity1 who had not received any systemic treatments. RESULTS: A total of 1889 recurrence-free survivors were eligible for analysis. No difference in @entity73 was found between survivors across standardized systemic treatment protocols when analyses were stratified by menopausal status and adjusted for possible sociodemographic and treatment-related confounders. The frequency of significant @entity73 in a subgroup of survivors in the age range 65-74 years was    7%. CONCLUSIONS: No differences in long-term @entity73 at 7-9 years post surgery were found between @entity1 who had received systemic therapies and those who had not. Furthermore, the observed proportion of survivors with significant @entity73 was comparable to normative data. These results are important to communicate to @entity1 , survivors, and clinicians alike, especially in the light of increasing concern about @entity73 following systemic therapies.British Journal of Cancer advance online publication, 14 July 2015; doi:10.1038/bjc.2015.243 www.bjcancer.com.
