[Initial results in the treatment of XXXX with the @entity4396 analog buserelin].

@entity1 @entity4396 @entity7458 @entity548 @entity1373 @entity53 @entity3202 @entity46 @entity158 @entity230
Twenty-six @entity1 , most of them with advanced @entity46 (Stage III according to Acosta), were treated for six months with the @entity4396 agonist @entity7458 . After initially increased liberation both of the gonadotropins as well as of the sexual @entity230 there was consecutive inhibition of gonadal function, especially after inhibition of FSH secretion. Within two to four weeks @entity53 production was completely and lastingly suppressed in 21 of the 26 @entity1 . In three @entity1 it lasted for three months and in two @entity1 @entity53 again rose up to three times during the period of observation. Correspondingly, 22 of the @entity1 suffered from hot flushes as early as within the first two months. Twenty of the 26 @entity1 became completely free of symptoms within four to six weeks, and a clear regression of the @entity158 was recorded in another four. In two @entity1 the complaints persisted without change. @entity548 of short duration occurred simultaneously with the intermittent increases in @entity53 levels; however, this bleeding usually caused little or no @entity158 . Eleven of the 19 endometrium biopsies performed during therapy revealed a dormant endometrium, and only in one case was proliferated endomedium found, in the third month of treatment, in a stage of transition to @entity1373 . The remaining seven biopsies were insufficient for assessment. In seven @entity1 with advanced @entity46 , laparotomies were performed after drug treatment. Histologic study of the @entity46 tissue thus obtained revealed, except in the two nonresponders, cicatrized tissue with @entity3202 and severely reduced stroma.(ABSTRACT TRUNCATED AT 250 WORDS)
