[The effects of thyroid hormones and XXXX levels on prognosis after congenital heart surgery].

@entity1 @entity998 @entity1955 @entity1458 @entity591 @entity520 @entity880 @entity687 @entity1954
OBJECTIVES: We evaluated the effects of thyroid hormone levels and @entity687 levels on prognosis in @entity1 undergoing congenital heart surgery under cardiopulmonary bypass (CPB). STUDY DESIGN: The study included 41 consecutive @entity1 (19 @entity1 , 22 @entity1 ; mean age 3.4    3.1 years; range 0.3 to 12 years). The @entity1 were divided into two groups based on the presence or absence of postoperative @entity998 ( @entity998 ). The definition of @entity998 included @entity1458 , @entity591 , @entity520 , and increased plasma @entity880 level. Plasma total (tT4) and free (fT4) @entity1955 , total (tT3) and free (fT3) @entity1954 , thyroid stimulating hormone (TSH), and @entity687 ( @entity687 ) levels were measured preoperatively and at 48 hours postoperatively. RESULTS: Postoperatively, nine @entity1 (22%) developed @entity998 . While the two groups were similar with respect to preoperative levels of thyroid hormones, @entity880 , and @entity687 , postoperative tT3 and fT3 levels were significantly lower, and @entity880 and @entity687 levels were significantly higher in the @entity998 group (p<0.05). In correlation analysis, postoperative @entity687 level showed significant correlations with CPB time (r=0.66), duration of mechanical ventilation (r=0.68), and inotropic requirement (r=0.59) (for all p<0.001). On the other hand, @entity998 was significantly correlated with the following: preoperative tT4 (r=-0.32, p=0.043) and postoperative fT3 (r=-0.44, p=0.004) levels, duration of mechanical ventilation (r=0.56, p<0.001), intensive care unit stay (r=0.45, p=0.003), and cross-clamp time (r=0.43, p=0.005). Regression analysis showed preoperative level of tT4 as the independent predictor of @entity998 (t=-2.092, p=0.045). Mortality occurred in four @entity1 (9.8%) in the early postoperative period, all of whom were in the @entity998 group. CONCLUSION: Our findings suggest that the development of @entity998 after congenital heart surgery is associated with decreased total and free T3, and increased @entity687 levels at 48 hours, and preoperative tT4 level is an independent predictor of @entity998 .
