Do subclinical electrographic XXXX patterns affect heart rate and its variability?

@entity1 @entity410 @entity75 @entity1315 @entity302 @entity4940 @entity299
PURPOSE: Autonomic symptoms during @entity410 may provide information on @entity410 onset zone. We investigated whether changes in @entity299 (HRV) occur during subclinical electrographic @entity410 patterns, and whether these have a localising/lateralising value. METHODS: EEG and ECG recordings of pharmacoresistant @entity302 @entity1 who underwent intracranial video-EEG telemetry were reviewed. Ultra-short-term HRV expressed as standard deviation of the mean before, during and after the subclinical @entity410 pattern was determined in 10s epochs. Statistics were done with a linear mixed regression model. Values are expressed as mean+/-SD. RESULTS: 26 @entity1 (38+/-10 years, 13 of either gender) have been included; 7 @entity1 with @entity1315 ( @entity1315 ) of either side as well as 7 (right-sided lesion) and 5 @entity1 ( @entity75 ) with @entity4940 ( @entity4940 ). A total of 74 subclinical events (2-3 per @entity1 ) were analysed. Pooled data for HR only weakly increased during and after the subclinical pattern with a mean HR of 80+/-10 bpm before to 82+/-11 bpm during (p=0.03) and 81+/-10 bpm after subclinical patterns (p=0.06). HR was higher in @entity1 with left @entity1315 as compared to right @entity1315 (p=0.001). In @entity4940 @entity1 only, the change in HR was correlated with the spatial extent of electrographic pattern localised (p=0.03). Mean HRV did not change during or after subclinical patterns. HRV was; however, lower in @entity1315 @entity1 with left-sided subclinical patterns as compared to right-sided patterns (pre-event HRV left 13+/-6 ms, right 34+/-16 ms). CONCLUSIONS: Our data revealed only minimal changes in autonomic cardiac function during highly localised electrographic @entity410 patterns and this had no localising/lateralising value.
