Pharmacologic characteristics of bladder micturition function in anesthetized XXXX .

@entity19 @entity2647 @entity16427 @entity3044 @entity551 @entity5402
In the present study, we observed the effects of an a(1)-adrenoceptor agonist ( @entity2647 ), b-adrenoceptor agonist ( @entity3044 ), muscarinic cholinoceptor agonist ( @entity5402 ), and a(1)-adrenoceptor antagonist ( @entity16427 ) on the bladder micturition function in anesthetized @entity19 . Changes in bladder pressure in response to filling and blood pressure were recorded by using a data acquisition system. @entity2647 (50 to 800  g/kg) increased vesical micturition pressure in a dose-dependent manner but increased micturition basal pressure only at 800  g/kg. @entity5402 (3 to 7  g/kg) increased the intercontraction interval and micturition time in a dose-dependent manner but increased micturition basal pressure only at 7  g/kg. @entity3044 (10 to 1000  g/kg) increased micturition time and decreased vesical micturition pressure in a dose-dependent manner. @entity16427 (10 to 1000  g/kg) did not affect bladder micturition function but dose-dependently inhibited @entity2647 -induced increases in vesical micturition pressure. @entity5402 (7  g/kg) and @entity3044 (1 mg/kg) caused a transient fall in blood pressure, whereas @entity16427 (1 mg/kg) had a long-lasting @entity551 effect. The maximal decrease in systolic and mean blood pressure by @entity5402 did not differ from that by @entity16427 and @entity3044 , respectively. @entity2647 (800  g/kg) transiently increased the blood pressure of anesthetized @entity19 . These results indicate that activation of muscarinic cholinoceptors decreases voiding frequency and increases bladder capacity in anesthetized @entity19 . Activation of a(1)-adrenoceptors mainly increases vesical micturition pressure, whereas activation of b-adrenoceptors decreases vesical micturition pressure and prolongs micturition time in anesthetized @entity19 .
