A longitudinal study of non-motor symptom burden in XXXX after a transition to expert care.

@entity1 @entity1109 @entity191
BACKGROUND: @entity1109 ( @entity1109 ) are common among @entity1 with @entity191 ( @entity191 ) however little is known about their progression in terms of severity or burden after referral to expert care. OBJECTIVE: This study was aimed to establish the progression of @entity1109 burden in @entity191 @entity1 after referral to tertiary healthcare centre and factors affecting it. METHODS: Newly referred @entity191 @entity1 were prospectively enrolled and follow-up for up to 18 months. @entity1109 scale (NMSS) was used to evaluate the burden of non-motor symptoms. RESULTS: There was a significant median reduction of total @entity1109 burden over the follow-up period. Similarly all @entity1109 domains except domains 2 (sleep/fatigue), 3 (mood/cognition), 6 (gastrointestinal) and 7 (urinary) showed significant median reduction of scores. In the univariate regression analysis, Hoehn _ Yahr staging, disease duration, visit, Schwab _ England Activities of Daily Living score and UPDRS motor scores were individually predictive of change in total @entity1109 burden. However, in the multivariable regression analysis only the latter three were significantly predictive of change in the total @entity1109 burden. CONCLUSION: There was a significant reduction of total @entity1109 burden over the study period. The severity of motor and activity of daily living impairments as well as subsequent visit were the best predictors of @entity1109 change.
