Selecting Potential Targetable Biomarkers for Imaging Purposes in XXXX Using TArget Selection Criteria (TASC): A Novel Target Identification Tool.

@entity1 @entity7 @entity5 @entity470 @entity14 @entity2355 @entity298
@entity298 ( @entity298 ) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of @entity298 @entity1 , which significantly increases overall survival rates up to 30%. As a consequence, there is substantial room for improvement. @entity5 targeting is expected to improve the treatment efficacy of @entity14 ( @entity14 ) further through 1) more sensitive preoperative @entity5 detection, thus reducing overtreatment; 2) better intraoperative detection and surgical elimination of residual disease using @entity5 -specific intraoperative imaging; and 3) @entity5 -specific targeted therapeutics. This review focuses, in particular, on the development of @entity5 -targeted imaging agents. A large number of biomarkers are known to be upregulated in @entity14 . However, to date, no validated criteria have been described for the selection of the most promising biomarkers for @entity5 targeting. Such a scoring system might improve the selection of the correct biomarker for imaging purposes. In this review, we present the TArget Selection Criteria (TASC) scoring system for selection of potential biomarkers for @entity5 -targeted imaging. By applying TASC to biomarkers for @entity14 , we identified seven biomarkers (carcinoembryonic antigen, CXC chemokine receptor 4, @entity470 , epithelial cell adhesion molecule, matrix metalloproteinases, @entity2355 , and @entity7 ) that seem most suitable for @entity5 -targeted imaging applications in @entity14 . Further cross-validation studies in @entity14 and other @entity5 types are necessary to establish its definitive value.
