Ectopic expression of embryonic stem cell and other developmental genes in XXXX .

@entity1 @entity2007 @entity16718 @entity4729 @entity2440 @entity38612 @entity5 @entity16719 @entity784 @entity5555 @entity11260 @entity4731 @entity72062 @entity24377 @entity23740 @entity42364
UNASSIGNED: @entity784 ( @entity784 ) is a potentially devastating @entity5 . The pathogenesis of this @entity5 remains poorly elucidated. Previous studies focused on analysis of expression and function of known oncogenes and @entity5 suppressor genes. However, emerging reports highlight that it is also important to analyze the expression of genes that are ectopically expressed in @entity784 (e.g., embryonic stem cell genes (ESC), @entity5 ( @entity5 ) genes, etc.). Currently, it is not known whether ESC genes are expressed in @entity784 . In the current work, we analyze by RT-PCR the expression of 26 ESC genes, many of which are known to regulate pluripotency and promote @entity5 stem cell-like phenotype, in a historic cohort of 60 @entity1 from Boston and in a panel of 11 @entity1 -derived @entity784 cell lines and compare such expression to benign inflammatory dermatoses that often clinically mimic @entity784 . Our findings document that many critical ESC genes including @entity2440 , @entity4731 , @entity4729 ( @entity4729 ) and their upstream and downstream signaling members are expressed in @entity784 . Similarly, polycomb repressive complex 2 (PRC2) genes (i.e., @entity16719 , @entity16718 , and @entity38612 ) are also expressed in @entity784 lesional skin. Furthermore, select ESC genes ( @entity4729 , @entity16718 , @entity11260 , @entity72062 , @entity23740 , @entity24377 , @entity42364 ) are preferentially expressed in @entity784 samples when compared to benign skin biopsies. Our work suggests that ESC genes are ectopically expressed together with @entity5 genes, thymocyte development genes and B cell-specific genes and may be working in concert to promote tumorigenesis. Specifically, while ESC genes may be promoting @entity5 stem cell-like phenotype, @entity5 genes may be contributing to @entity2007 and @entity5555 by producing aberrant chromosomal translocations. Further analysis of ESC expression and function in this @entity5 will greatly enhance our fundamental understanding of @entity784 and will help us identify novel therapeutic targets.
