Lesion Expansion in Experimental XXXX Animal Models and @entity15 Lesions.

@entity1 @entity17 @entity6579 @entity19 @entity18 @entity62 @entity15
UNASSIGNED: Gray matter pathology is an important aspect of @entity15 ( @entity15 ) pathogenesis and disease progression. In a recent study, we were able to demonstrate that the higher myelin content in the white matter parts of the brain is an important variable in the neuroinflammatory response during demyelinating events. Whether higher white matter myelination contributes to lesion development and progression is not known. Here, we compared lesion size of intra-cortical vs. @entity62 . Furthermore, dynamics of lesion development was compared in the @entity18 and @entity6579 models. We provide clear evidence that in the @entity1 brain, @entity62 are significantly increased in size as compared to intra-cortical gray matter lesions. In addition, studies using the @entity18 @entity19 model revealed that the autonomous progression of @entity62 is more severe compared to that in the gray matter. Focal @entity17 revealed that the application of equal amounts of @entity6579 results in more severe @entity17 in the white compared to the gray matter. In summary, lesion progression is most intense in myelin-rich white matter regions, irrespective of the initial lesion trigger mechanism. A better understanding of myelin debris-triggered lesion expansion will pave the way for the development of new protective strategies in the future.
