Neuroprotective effects of XXXX on blunt @entity542 : An experimental study on @entity35 .

@entity1545 @entity2657 @entity2930 @entity75 @entity16 @entity542 @entity35 @entity803
BACKGROUND: Prevention of primary damage caused by @entity542 may be avoided with protective measures and techniques which is a public health concern. Experimental and clinical studies about treatment of @entity542 were all centered to prevent @entity16 caused by physiopathological changes following primary injury. Neuroprotective features of @entity2930 were the focus of several experimental studies in the last decade. In the present study we aimed to investigate the neuroprotective effects of @entity803 in an experimental model of blunt @entity1545 in @entity35 . MATERIALS AND METHODS: 32 male @entity35 were divided into four experimental groups (n = 8). @entity542 was not performed in control group (group 1, craniectomy only). In the second group, @entity542 and craniectomy were performed. Intraperitoneal saline was used in addition to trauma and craniectomy for treatment in group 3 whereas intraperitoneal @entity803 and saline were used for treatment in group 4. RESULTS: When histological examinations performed by transmission electron microscopy were evaluated, injury at ultrastructural level was demonstrated to be less pronounced in @entity803 group with decreased lipid peroxidation levels. CONCLUSION: In accordance with these findings, we conclude that systemic @entity803 administration is effective in reduction of secondary @entity75 and @entity2657 and thus it may be considered as a therapeutic option.
