The prognostic value of pretreatment of systemic inflammatory responses in XXXX with @entity189 undergoing radical cystectomy.

@entity1 @entity5 @entity189 @entity150 @entity204 @entity1349 @entity1851
UNASSIGNED: Background:Systemic inflammatory response (SIR) is important in the relationship between the @entity5 , the host, and outcome in @entity5 @entity1 . However, limited data exist regarding the prognostic significance of SIR in @entity150 . We investigate the utility of pretreatment SIR in @entity1 with @entity189 undergoing radical cystectomy.Methods:The study cohort consisted of 419 @entity1 with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: @entity1851 , albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and @entity1349 ( @entity1349 ) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and @entity1349 probability.Results:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for @entity204 from @entity150 . The nomograms including each index were developed to predict the probability of 5-year DSS and @entity1349 after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR.Conclusions:Cellular components of SIR have better prognostic values compared with acute-phase protein in @entity1 undergoing radical cystectomy for @entity150 .
