XXXX signaling during platelet activation.

@entity1 @entity4089 @entity2013 @entity49 @entity12595 @entity4090 @entity857 @entity1211
@entity4090 is a newly recognized platelet coactivator that functions through potentiation of @entity857 -induced platelet activation. However, the possible association between @entity4089 and @entity1211 ( @entity1211 ) has not been systematically investigated up to now; @entity4090 signaling mechanisms in platelets still need to be elucidated. In this study, plasma @entity4090 levels in healthy subjects and @entity1 with @entity1211 were determined, demonstrating that @entity1 with @entity1211 and no other congenital risk factors had significantly increased plasma @entity4090 levels. Moreover, @entity2013 @entity1 demonstrated a higher incidence of @entity1211 than the general population. To elucidate the molecular mechanisms for the development of @entity49 , @entity12595 signaling during platelet activation was investigated with a focus on @entity857 -stimulated G-protein-regulated signaling pathways. The short isoform of @entity4090 receptors was detected on platelets. Signaling through this receptor, although not directly linked to Gq-proteins, substitutes for Gq-protein regulated signaling pathways involved in platelet activation. We identified protein kinase C, a well-established signaling molecule in platelet activation, as a target molecule for @entity4090 signaling pathways in @entity1 platelets. Our findings indicate that @entity4089 may be an important novel risk factor for @entity1211 , suggesting that its thrombogenic effect may be mediated through enhanced platelet reactivity. Revealing the molecular mechanisms of @entity4090 signaling will allow the design of new antithrombotic therapies.
