Effect of patulin on hepatic monooxygenase in male XXXX .

@entity17690 @entity19 @entity1110 @entity8953 @entity7680 @entity9308
The in vivo effects of patulin on hepatic monooxygenase enzymes in male @entity19 were examined after single and multiple exposures (i.p.) to the mycotoxin. The animals were exposed to a single dose of 1, 3 or 4.5 mg patulin/kg or daily doses of 1.0 mg/kg for 5 or 14 days. After single exposure no significant effect was observed on @entity8953 hydroxylation while @entity9308 hydroxylase increased significantly at 3 mg/kg and at 48 hr. The demethylation of @entity17690 and @entity7680 increased significantly 48 and 72 hr after 3.0 or 4.5 mg patulin/kg doses. A 12% increase was observed in cytochrome P-450 content 48 hr after exposure to 1 or 3 mg/kg. @entity1110 -cytochrome C reductase was enhanced significantly at all 3 dose levels at 48 hr. At 24 hr hepatic @entity1110 -dependent dehydrogenase activity increased 38 and 46% in animals exposed to a single dose of 3 mg patulin/kg, respectively. No effect of patulin was observed on the hepatic drug metabolizing enzymes examined except hexobarbital oxidation in @entity19 exposed to multiple doses of patulin. Patulin at best was a weak inducer of the hepatic mixed function oxidase system.
