Brief behavioral therapy for refractory XXXX : an assessor-blind, randomized controlled trial.

@entity1 @entity308 @entity348 @entity5624 @entity22
OBJECTIVE: @entity22 often persists despite pharmacotherapy in @entity308 and represents an obstacle to its full remission. This study aimed to investigate the added value of brief behavioral therapy for @entity22 over treatment as usual ( @entity5624 ) for @entity308 and @entity22 . METHOD: Thirty-seven outpatients (mean age of 50.5 years) were randomly assigned to @entity5624 alone or @entity5624 plus brief behavioral therapy for @entity22 , consisting of 4 weekly 1-hour individual sessions. The @entity22 Severity Index (ISI) scores (primary outcome), sleep parameters, and GRID-Hamilton Depression Rating Scale (GRID-HAMD) scores were assessed by blind raters and remission rates for both @entity308 were collected at 4- and 8-week follow-ups. The @entity1 were recruited from February 18, 2008, to April 9, 2009. RESULTS: Brief behavioral therapy for @entity22 plus @entity5624 resulted in significantly lower ISI scores than @entity5624 alone at 8 weeks (P < .0005). The sleep efficiency for the combination was also significantly better than that for @entity5624 alone (P = .015). Significant differences were observed in favor of the combination group on both the @entity348 (P = .013) and the GRID-HAMD scores after removing the 3 sleep items (P = .008). The combination treatment produced higher rates of remission than @entity5624 alone, both in terms of @entity22 (50% vs 0%), with a number needed to treat (NNT) of 2 (95% CI, 1-4), and in terms of @entity308 (50% vs 6%), with an NNT of 2 (95% CI, 1-5). CONCLUSIONS: In @entity1 with @entity308 and treatment @entity22 , adding brief behavioral therapy for @entity22 to usual clinical care produced statistically significant and clinically substantive added benefits. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00610259.
