Recalling word lists reveals "cognitive dysmetria" in XXXX : a positron emission tomography study.

@entity1 @entity161 @entity4940
OBJECTIVE: This study explored the neural circuitry used during recall of unstructured verbal material in @entity161 @entity1 and healthy volunteer subjects. METHOD: The subjects were 13 healthy volunteers and 14 @entity161 @entity1 . All @entity1 were free of medication, and all subjects were right-handed. Two experimental cognitive conditions were used: recall of novel and practiced word lists (two 15-item lists from the Rey Auditory Verbal Learning Test). Both active recall tasks were compared with an eyes-closed resting baseline condition. A nonparametric randomization test was used to determine within- and between-group differences in regional cerebral blood flow. RESULTS: Performance on both the practiced and novel memory tasks was nonsignificantly different in the @entity1 and control subjects. During the novel memory task, the @entity1 showed decreased flow in the right anterior cingulate, right thalamus, and bilateral cerebellum (left greater than right) relative to the control subjects. When recalling the practiced word lists, the @entity1 showed decreased flow in the left dorsolateral prefrontal cortex, bilateral medial frontal cortex, @entity4940 , left thalamus, left cerebellar regions, anterior vermis, and right cuneus. CONCLUSIONS: @entity1 with @entity161 fail to activate cortical-cerebellar-thalamic-cortical circuitry during recall of both well-learned and novel word lists.
