[Effects of XXXX on sexual development].

@entity1 @entity3610 @entity251 @entity3428 @entity1092 @entity2494 @entity53 @entity3190 @entity1017 @entity302 @entity2671 @entity3427
INTRODUCTION: @entity1092 use in young @entity1 has been associated with the adverse endocrinological effects of @entity1017 and @entity3428 . Furthermore, @entity3610 and @entity3190 have been described in adult @entity1 . In @entity1 and young @entity1 , however, the possible adverse endocrinological effects of @entity1092 have scarcely been analyzed. OBJECTIVES: The aim of this study was to evaluate the effects of @entity1092 treatment on pubertal development, especially the possible hyperandrogenic effects, in @entity1 and @entity1 with @entity302 . MATERIAL AND METHODS: Twenty-three @entity1 and 15 @entity1 (aged 8-16 years old) who were undergoing @entity1092 treatment for @entity302 were compared with 15 control @entity1 and 10 control @entity1 of the same age range. Anthropometric indexes, sexual maturation, and @entity3427 scores were evaluated. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), @entity251 , @entity2671 , @entity2494 , @entity53 , and insulin were measured. Ultrasound examination of ovaries and estimation of bone age through X-ray of the left hand were also performed. RESULTS: @entity1092 did not affect pubertal development in the study group. No @entity3427 or @entity3610 were found. Increases in weight, relative weight, and body mass index were observed in the group undergoing @entity1092 treatment, but no statistically significant differences compared with the control group were found. Plasma @entity251 was higher in @entity1092 -treated @entity1 (0.71 0.51 ng/ml) than in control @entity1 (0.35 0.15) (p 0.001). This finding was independent of @entity1092 dose and treatment duration. @entity3428 was not found in @entity1092 -treated @entity1 . CONCLUSIONS: @entity1092 may induce @entity3428 in @entity302 @entity1 but not in @entity1 . This is an early adverse effect and is independent of the dose used. No changes in normal pubertal development or physical repercussions were found in @entity302 @entity1 .
