DNA ploidy is stronger than @entity1600 as prognostic factor in XXXX : 10-year results of a prospective study.

@entity1 @entity1600 @entity2622 @entity5
INTRODUCTION: To improve the outcome of @entity1 with @entity5 , a more accurate prognostic assessment is essential. The aim of this study was to evaluate the role of @entity5 DNA ploidy as an independent prognostic factor in @entity2622 . Furthermore, we investigated whether the presence of @entity1600 may have a different clinical impact according to ploidy status. METHODS: In a long-term prospective study, DNA ploidy was evaluated by flow cytometry from fresh @entity5 samples from 136 @entity1 with @entity5 who underwent surgery. Ploidy, @entity1600 , and other classical parameters were analyzed in relation to the length of disease-specific survival. Treatment modalities did not differ between @entity1 with @entity5 and @entity1 with @entity5 . RESULTS: DNA aneuploidy was found in 52 @entity1 (38.2%). @entity1 with @entity5 had a significantly reduced disease-specific survival (P = 0.003). Overall, the 10-year survival probability was 54% for @entity1 with @entity5 and 80% for @entity1 with DNA- @entity5 . Among 64 @entity1 with International Federation of Gynecologists and Obstetricians stage I disease, the 10-year survival rates were 38.7% for the @entity1 with @entity5 and 86.3% for those with DNA- @entity5 (P = 0.003). Overall, @entity5 with @entity1600 did significantly better than @entity5 with @entity1600 (P = 0.05). Among the @entity1 with International Federation of Gynecologists and Obstetricians stage I disease, there was a highly significant difference between @entity1 with @entity5 and @entity1 with @entity5 , with no deaths from the disease in the former group in contrast with the worst outcome in the latter group (P = 0.005). By multivariate analysis, pathologic @entity5 stage, lymph vascular invasion, and @entity5 ploidy were significant and independent parameters, whereas @entity1600 yielded no independent information. CONCLUSIONS: DNA ploidy was an independent prognostic factor in @entity2622 . Presence of @entity1600 may not always have the same impact on survival but may vary according to DNA ploidy of the @entity5 .
