[Research on the efficacy and mechanism of standardized house dust mite allergen vaccine to XXXX ].

@entity6542 @entity1 @entity1984 @entity404 @entity2023 @entity56 @entity403
OBJECTIVE: The study was designed to analyze the efficacy of standardized house dust mite allergen vaccine to @entity2023 by subcutaneous injection and investigate the possible mechanism of @entity6542 ( @entity6542 ). METHODS: From January 2011 to December 2011 a prospective study was performed in the Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Nantong University, involving 90 @entity1 with perennial @entity1984 , of whom 60 @entity1 received Der p - @entity6542 + pharmacotherapy after their approval and 30 received only pharmacotherapy. All @entity1 were @entity56 to house dust mites. Symptom and medication scores were recorded three times: before the treatment, at the middle of treatment and at the end of treatment. Over a period of 1 yr. prior to and at the end of treatment, @entity404 (+) CD25(+) @entity403 (+) Treg cells and Th17 cells were measured by flow cytometry. SPSS 21.0 software was used to analyze the data. RESULTS: The symptom scores using VAS and medication scores in @entity1984 @entity1 treated with @entity6542 and medication were reduced, the differences were significant (14.25    6.40, 1.00    0.84 vs. 32.18    7.78, 3.12    1.54, t value was 19.65, 10.71, both P < 0.05). The symptom of VAS score in medication group was reduced after treatment (30.30    5.97 vs. 20.30    5.79, t = 10.09, P < 0.05), but the medication score had not significant difference (P > 0.05). The frequency of Th17 cells in peripheral blood mononuclear cells were decreased in @entity1 treated with @entity6542 , whereas the frequency of Treg cells were increased (  (2) value was 2.81, 2.80, both P < 0.05), but not in medication group. CONCLUSIONS: Both @entity6542 and pharmacotherapy can improve symptoms of @entity2023 , but @entity6542 can also reduce medication use. The effect of immunotherapy is better than drug treatment alone. The frequency of blood Th17 cells in peripheral blood mononuclear cells were decreased in @entity1 treated with @entity6542 , whereas the frequency of Treg cells were increased.
