Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 XXXX .

@entity455 @entity6 @entity1011 @entity1317 @entity122
OBJECTIVE: We previously reported ethnic disparity in adverse outcomes among Asians with type 2 @entity6 (T2DM) in Singapore. Central arterial stiffness can aggravate systemic @entity455 by propagating elevated systolic and pulse pressures forward, thereby accentuating global @entity1317 . We aim to study ethnic disparity in central arterial stiffness and its determinants in a multi-ethnic T2DM Asian cohort. METHODS: Arterial stiffness was estimated by carotid-femoral pulse wave velocity ( @entity122 ) and augmentation index (AI) using applanation tonometry method in Chinese (N  =  1045), Malays (N  =  458) and Indians (N  =  468). Linear regression model was used to evaluate predictors of @entity122 and AI. RESULTS: @entity122 was higher in Malays (10.1      3.0  m/s) than Chinese (9.7      2.8  m/s) and Indians (9.6      3.1  m/s) (P  =  0.018). AI was higher in Indians (28.1      10.8%) than Malays (25.9      10.1%) and Chinese (26.1      10.7%) (P  <  0.001). Malays remain associated with higher @entity122 (b  =  0.299, P  =  0.048) post-adjustment for age, gender, duration of @entity6 , hemoglobin A1c, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), soluble receptor for advanced glycation end-products, urinary albumin-to- @entity1011 ratio, and insulin usage, which were all independent predictors of @entity122 . Indians remain associated with higher AI (b  =  2.776, P  <  0.001) post-adjustment for age, gender, BMI, SBP, DBP, and height, which were independent predictors of AI. These variables explained 27.7% and 33.4% of the variance in @entity122 and AI respectively. CONCLUSIONS: Malays and Indians with T2DM have higher central arterial stiffness, which may explain their higher risk for adverse outcomes. Modifying traditional major vascular risk factors may partially alleviate their excess cardiovascular risk through modulating arterial stiffness.
