Antihypertensive effects of the XXXX antagonistic agent @entity594 .

@entity1 @entity1671 @entity390 @entity101 @entity7206 @entity460 @entity594 @entity10 @entity551
The @entity460 antagonist @entity594 (Adalat) was administered to 60 @entity1 with essential @entity101 and investigations were performed on acute and chronic @entity551 effects. The following results were obtained: 1. Acute @entity551 effects: @entity594 (20 mg) was either orally or sublingually administered. Following oral administration, significant @entity551 effect was attained 20 min after administration and the maximum @entity551 response was obtained 2-4 h after administration. In cases of sublingual administration, significant @entity551 effect was notable 5 min after administration and blood pressure reached the lowest level 2-3 h after administration. The @entity551 effects lasted for a relatively longer period and significantly lower blood pressure than the control level was observed even 3 h after administration. 2. @entity551 effects: @entity594 (30-60 mg/d) was orally administered consecutively. Significant @entity551 effect was attained in and after the 4th week of administration. The yearly changes in the long-term administration cases over 3 years demonstrated significant @entity551 effects. The cases who did not respond to single administration of @entity7206 or beta-blockers exhibited significant @entity551 response by the combined use of @entity594 . 3. Change in heart rate: In the acute study, heart rate increased after @entity594 administration and lasted for several hours. In the long-term administration cases, the changes in heart rate were not significant. 4. Side effects attributable to @entity594 such as @entity10 in 2 cases, @entity1671 , warm sensation and @entity390 in 1 case each were observed early after the administration but there were no cases in whom administration was discontinued due to these side effects.
