The Association between Obstructive Sleep Apnea on XXXX : A Systematic Review and Meta-Analysis.

@entity1 @entity6 @entity2316 @entity26 @entity27 @entity24 @entity3612
STUDY OBJECTIVE: This systematic review aims to summarise the association between @entity27 ( @entity27 ) and @entity2316 ( @entity2316 ). DESIGN: MeSH terms and free text searches were performed on MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception to April 2015. Zetoc and OpenGrey databases were queried for grey literature, and lastly, hand searches were carried out. Study selection and quality assessment were conducted by two authors. One author carried out data extraction, which was checked by other authors. The relationships between @entity27 index (AHI), @entity26 desaturation index (ODI), time spent under 90% @entity26 saturation (% @entity24 <90), and minimum and mean @entity26 saturation ( @entity3612 ) on @entity2316 were examined. MEASUREMENT AND RESULTS: Two longitudinal and ten cross-sectional studies were included for our narrative synthesis, and seven studies for meta-analysis. Studies that performed multi-variable analysis demonstrated significant associations between @entity27 (assessed using either @entity27 index or ODI) and @entity2316 in @entity6 ( @entity6 ). This was confirmed by meta-analysis (pooled OR 1.73, 95% CI: 1.13-2.64). There was some evidence to suggest that % @entity24 <90 may have an association with @entity2316 . There was insufficient evidence to conclude on the relationship between minimum and mean @entity26 saturation on @entity2316 . There was no evidence available on the associations between @entity27 and other respiratory parameters in type 1 @entity6 populations. CONCLUSION: There is moderate evidence that @entity27 is associated with @entity2316 in @entity1 with @entity6 . Large prospective studies with long-term follow up are needed to assess the possible bi-directional mechanisms between @entity27 and @entity2316 .
