Local control rate of split-course irradiation combined with chemotherapy for XXXX .

@entity1 @entity135 @entity138 @entity957 @entity33
Between 1976 and 1984, 99 @entity1 were treated with radical external irradiation ( @entity138 ) for @entity957 of the @entity135 excluding the glottis and paranasal cavity. Twenty-six out of 55 @entity1 (47%) on chemotherapy (CT) were treated by split-course (split) @entity138 , mainly because of acute @entity33 . Only 8 out of 44 @entity1 (18%) not on CT were treated by split @entity138 . Although the group given split @entity138 alone rested for 14 days and received 35 Gy, the split @entity138 + CT group rested for 16 days and received a lower dose (30.5 Gy). The mean total doses for each treatment modality were 64 Gy in the continuous course (contin.) of @entity138 alone, 63 Gy in contin. @entity138 + CT, 67 Gy in split @entity138 , and 62 Gy in split @entity138 + CT. The observed/predicted (by a Radiation Therapy Oncology Group) control ratios of primary lesions at 2 yrs were 61/80 (0.76), 72/83 (0.87), 75/73 (1.03), and 69/71 (0.97), respectively. Among @entity1 with a predicted rate of over 80%, the observed rates were almost identical (72%, 74%, 4/4, and 75%, respectively). However, for @entity1 with predicted rates of 50-80%, the observed rate was 71% (12/17) in the group given combined therapy against 50% (5/10) in @entity138 alone group. Among @entity1 with predicted rates under 50%, the observed rate was 57% (4/7) in split @entity138 + CR and only 25% (1/4) in contin. @entity138 ; there were no cases in contin. @entity138 + CT. Split @entity138 + CT is considered to be favorable for @entity1 with poor prognostic factors.
