Malignant transformation of perianal and XXXX is rare: results of 17 years of follow-up from The Netherlands.

@entity1 @entity5 @entity420 @entity292 @entity30 @entity1141 @entity4570
OBJECTIVE: Malignant transformation of @entity292 has been observed, particularly in perianal @entity292 in @entity30 ( @entity30 ) @entity1 . The prevalence of @entity420 in @entity4570 and non- @entity30 -related @entity292 , however, is unknown. We investigated @entity420 originating from perianal and @entity4570 in both @entity30 @entity1 and non- @entity30 @entity1 from nine large, mostly tertiary referral, hospitals in The Netherlands. METHODS: @entity1 suffering from fistulizing disease and either @entity1141 or @entity420 between January 1990 and January 2007 were identified using the nationwide automated pathology database (PALGA). Clinical and histopathological data were collected and verified using hospital @entity1 -charts and reported by descriptive statistics. The total @entity30 -population comprised 6058 @entity1 . RESULTS: In a study-period of 17 years, 2324 @entity1 with any @entity292 were reported in PALGA. In 542 @entity1 , @entity1141 or @entity420 was also mentioned. After initial review and additional detailed chart review, 538 @entity1 were excluded, mainly because the @entity420 was not related to the @entity292 . In the remaining four @entity1 , all suffering from @entity30 , @entity420 originating from the @entity292 -tract was confirmed. The @entity5 developed 25 years (IQR 10-38) after @entity30 diagnosis, and 10 years (IQR 6-22) after @entity292 diagnosis. Median age at time of @entity420 diagnosis was 48.3 years (IQR 43-58). Only one @entity1 had clinical symptoms indicative for @entity420 . In three other @entity1 , the @entity420 was found coincidently. CONCLUSIONS: @entity420 complicating perianal or enterocutaneous @entity292 -tracts is a rare finding. Only 4 out of 6058 @entity30 @entity1 developed a @entity292 -associated @entity420 . We could not identify any malignant transformations in non- @entity30 -related @entity292 in our 17 years study-period.
