Differentiation of @entity792 from Graves' XXXX by analysis of genetic markers.

@entity1 @entity2194 @entity101 @entity5147 @entity2743 @entity4106 @entity1378 @entity24481 @entity2149 @entity6875 @entity792
Graves' @entity1378 and @entity2194 are closely related @entity792 . Whether the @entity2194 is an integral part of @entity2743 or a separate entity is controversial. To investigate this we have examined the genetic associations of @entity6875 and @entity1378 , and compared their phenotype and gene frequencies with a control normal population. @entity2149 , and DR antigens were typed in 67 @entity1 with @entity2194 ( @entity24481 ), 60 @entity1378 @entity1 without significant @entity2194 ( @entity101 ) and 500 normal subjects. @entity1 were also typed for a variety of other genetic markers: blood group systems (10), serum proteins (6) and red cell enzyme systems (10). Increased frequency of B8 and @entity4106 in @entity2743 was confirmed; @entity5147 occurred less frequently and appears to be protective. HLA antigen frequencies for @entity24481 did not differ from @entity101 . The MNS blood group showed a significant association with @entity2743 , the @entity101 @entity1 having a deficit of the s gene compared with controls. The most interesting finding was an increased frequency of blood group P in @entity24481 @entity1 compared with either @entity101 or controls. Significant differences were not seen with any of the other HLA antigens, blood groups, protein or enzyme markers considered individually. Multivariate analysis applied first to the HLA and then to the non-HLA systems indicated clear separation of the two @entity1 groups. Although @entity2194 shares the same HLA associations as @entity1378 , it differs in the increased frequency of P blood group, suggesting that additional genetic factors may determine which @entity1 with @entity2743 develop @entity6875 .
