Genomic characterisation of @entity235 papillomavirus type 17, a possible rare cause of XXXX @entity957 .

@entity5 @entity24715 @entity957 @entity235
@entity957 ( @entity957 ) are the second most common @entity5 of the @entity235 oral cavity resulting in significant morbidity and mortality. Recently a @entity235 with multiple oral @entity957 that contained a novel papillomavirus (PV) was reported. The aim of the present study was to determine the genome of this novel PV. To do this a short section of PV DNA was amplified from an oral SCC and 'back-to-back' primers were designed. Due to the circular nature of PV DNA, these primers were then used to amplify the remainder of the genome by inverse PCR. The PCR product was sequenced using next generation sequencing and the full genome of the PV, consisting of 8007 bp, was assembled and analysed. As this is the seventeenth PV identified from the domestic @entity235 , the novel PV was designated @entity235 papillomavirus ( @entity24715 ) type 17. Similar to other @entity24715 types, the putative coding regions of @entity24715 -17 were predicted to produce 5 early and 2 late proteins. Phylogenetic analysis of ORF L1 revealed greater than 70% similarity to @entity24715 -2 and @entity24715 -7 and we propose that @entity24715 -17 also be classified as a Taupapillomavirus 1. While it appears @entity24715 -17 is only rarely present in @entity235 oral @entity957 , evidence suggests that this PV could influence the development of oral @entity957 in this species.
