[Fundamental and clinical studies of XXXX in the field of pediatric].

@entity1 @entity697 @entity8966 @entity2348 @entity693 @entity5647 @entity5746 @entity1729 @entity293 @entity3127 @entity5646 @entity526
The fundamental and clinical studies of @entity5646 ( @entity5647 ) were performed. The results were as follows: The MICs of @entity5647 for @entity526 and @entity5746 sp. which were recently isolated in the pediatric field were less than 0.78 micrograms/ml. @entity5647 also was effective against ABPC/PIPC-resistant bacteria. The MIC of @entity5647 for @entity8966 was less than 1.56 micrograms/ml. The peak serum levels of @entity5647 which were occurred just after the 1 hour drip infusion of 10-30 mg/kg were 60.5-136.8 micrograms/ml, and at 6 hours after infusion the serum levels were 1.3-6.1 micrograms/ml; therefore, the dose response was proved. The mean half-lives (T 1/2) were between 1.21 and 1.36 hours. The excretion rates in urine up to 6 hours after intravenous drip infusion were between 32.7 and 77.5%. The ratio of the cerebrospinal fluid concentration to serum in the @entity1 with @entity693 was 3.5% at 1 hour after the intravenous injection at the dose of 69 mg/kg, and the ratios of the subdural fluid levels to serum were 31.3-37.5%. The levels of @entity5647 into the feces by the multiple dosage were 0-840 micrograms/g. Twenty-five pediatric @entity1 with @entity697 had been treated by intravenous injection or drip infusion at the doses of 49-120 mg/kg/day (almost 50-100 mg/kg/day) for 4 to 13 days. The efficacy rate of excellent + good was 84% and that of excellent + good + fair was 96%. The efficacy rate of excellent + good was 100% in all cases with @entity1729 , @entity3127 , and @entity293 caused by Gram-negative rods. The clinical efficacy was observed in all cases with acute @entity2348 . Although @entity5647 was clinically effective against @entity5746 , bacteriological efficacy on the causative organisms was not observed in some cases. Although @entity5647 was bacteriologically effective in 1 @entity1 with typhoid, it did not alleviated fever. @entity5647 showed activity to 9 strains isolated from the culture of throat swab, urine and feces. No side effects were clinically observed in all cases, while slight elevations of laboratory findings were observed in 4 cases.
