Low plasma volume following pregnancy complicated by @entity1468 predisposes for XXXX disease in a next pregnancy.

@entity1 @entity101 @entity2102 @entity412 @entity1468
OBJECTIVE: A large number of @entity1 with a history of @entity1468 have a low plasma volume at least six months postpartum. The objective of this study was to determine whether a low plasma volume in formerly pre-eclamptic @entity1 and @entity2102 @entity1 is associated with an increased risk for recurrent @entity101 complications in a next pregnancy. DESIGN: Prospective observational study. SETTING: Tertiary obstetric centre. SAMPLE: Formerly pre-eclamptic @entity1 and controls. METHODS: In 316 @entity1 with a history of @entity1468 and/or @entity2102 , we measured, plasma volume along with haemodynamic, metabolic and haemostatic variables at least six months postpartum. A group of 22 healthy parous controls was used as a reference. After standardising plasma volume for body mass index, @entity1 were subdivided into normotensive and normal plasma volume (n = 199), normotensive and low plasma volume (n = 76) and @entity101 (n = 41) subgroups, which were compared for demography, clinical parameters and course of a next pregnancy. MAIN OUTCOME MEASURES: Recurrent @entity101 . RESULTS: Relative to the normal plasma volume subgroup, normotensive @entity1 in the low plasma volume subgroup have a higher body mass index, a lower total vascular compliance and a shorter estimated systemic circulation time. They have a higher HOMA index and higher fasting @entity412 levels. In normotensive and @entity101 former @entity1 alike, low plasma volume is associated with a higher recurrence of @entity101 complications in a next pregnancy compared with normotensive @entity1 with normal plasma volume. CONCLUSION: Low plasma volume in normotensive @entity1 with a history of @entity1468 and/or @entity2102 is associated with overweight, reduced vascular compliance and insulin resistance and a predisposition for recurrent @entity1468 and @entity2102 in a next pregnancy.
