The dermatan @entity597 -dependent anticoagulant pathway is mostly preserved in @entity439 and in severe @entity731 while the heparan XXXX pathway is disrupted.

@entity1 @entity556 @entity439 @entity731 @entity1028 @entity597
BACKGROUND: The pathogenesis of @entity1028 is associated with changes of several components of arterial wall. Vascular glycosaminoglycans contribute to the non-thrombogenic activity of blood vessels. We investigated whether modifications of glycosaminoglycans in @entity1 @entity1028 affect their anticoagulant properties. METHODS: Glycosaminoglycans were extracted from @entity1028 (n=11) derived from reconstitution surgeries, @entity1 abdominal aortas (n=9) from normal organ transplant donors and from preserved (n=10) and @entity731 (n=17) segments obtained from autopsy of an old @entity1 . Glycosaminoglycan composition, concentration and anticoagulant activity were determined. RESULTS: Glycosaminoglycans extracted from @entity439 have a more potent anticoagulant activity than those from normal arteries of young adults, mostly due to a relative enrichment of dermatan @entity597 , which potentiates heparin cofactor II inhibition of @entity556 . Arterial segments of aged @entity1 with severe @entity731 showed a glycosaminoglycan composition similar to @entity439 samples. Glycosaminoglycans extracted from these regions showed also a more potent heparin cofactor II-dependent anticoagulant activity than lesion-free areas due to the relative enrichment of dermatan @entity597 . CONCLUSION: The anticoagulant activity from @entity1028 is preserved. No modifications particular to the @entity439 were dissociated from those observed in @entity731 .
