XXXX : clinical features, cytogenetics, and prognosis in 30 consecutive cases.

@entity1 @entity417 @entity548 @entity6130 @entity4125 @entity11140 @entity3052 @entity2008
A retrospective analysis of 30 @entity1 with @entity6130 ( @entity6130 ) was performed to define the natural history of the disease and the risk of acute transformation. Our @entity1 fulfilled the following criteria of diagnosis: blood monocytosis over 1 X 10(9)/l, blast cell percentage in bone marrow up to 30, and in peripheral blood less than 5. The most common presenting feature was @entity417 ; seven @entity1 had fever; three @entity1 @entity4125 and @entity548 . Anysopoikilocytosis and @entity11140 were frequent. Abnormal granulocyte morphology, defective granulation and abnormal leukocyte alkaline phosphatase were often observed. Blast cells in peripheral blood smears were found in 14 patients. Serum and urine lysozyme levels were increased in 82 per cent and 93 per cent, respectively. Dysplastic changes involving erythroid, granulocytic and megakaryocytic lineages were constant features in all cases. Agranulated blasts above 5 per cent of marrow nucleated cells were seen in 13 @entity1 (43 per cent). Seven of the 20 @entity1 showed non-specific @entity2008 at diagnosis. Median survival from diagnosis was 18 months (range, 3-112). Evolution into @entity3052 occurred in 11 @entity1 . No difference in survival was found between @entity1 who developed @entity3052 and @entity1 who did not. A shorter survival has correlated to the following parameters: leukocytes greater than 10 X 10(9)/l, the presence of blasts in peripheral blood and agranulated blasts in the marrow above 5 per cent.
