XXXX : A review of the literature.

@entity1 @entity1204 @entity242 @entity5 @entity6962
OBJECTIVE: Uterine @entity6962 (UCSs) are aggressive @entity5 previously considered to be @entity242 , but now recognized as @entity5 composed of metaplastic transformation of epithelial elements. Much of the management for UCS has been extrapolated from studies of @entity1204 and @entity242 . This article critically reviews the literature pertinent to the pathology, pathogenesis, diagnosis and management of @entity1 with UCS. METHODS: MEDLINE was searched for English language literature on UCS with a focus on the past 20years. Given the rarity of this @entity5 , studies were not limited by design or number of reported @entity1 . RESULTS: UCS is biologically a de-differentiated @entity1204 with its own pathogenesis and molecular profile. It commonly presents with extrauterine disease which can be identified by comprehensive surgical staging. Most UCS @entity1 are candidates for adjuvant chemotherapy. The role of radiation is less clear. Combination therapy, while commonly used, has not been studied in depth. The high recurrence rate and poor overall survival for UCS suggest an ongoing need for clinical trials for UCS specifically. CONCLUSIONS: UCS represents a distinct subtype of uterine @entity5 , and should be studied as such via focused clinical trials.
