XXXX and @entity453 .

@entity1 @entity32 @entity1187 @entity296 @entity583 @entity908 @entity1459 @entity397 @entity453 @entity731 @entity1851
Evidence suggests that @entity32 plays a key role in the pathogenesis of @entity731 . The chronic inflammatory process can develop to an acute clinical event by the induction of @entity397 and therefore cause @entity1187 . The aim of this study was to determine the serum levels of the circulating acute-phase reactant @entity1851 (CRP), which is a sensitive indicator of @entity32 , in @entity1 with chronic stable @entity453 ( @entity453 ) and @entity1187 ( @entity1187 ). We studied 56 subjects: 1) 25 consecutive @entity1 (18 @entity1 , 7 @entity1 ; mean age, 68.5 +/- 14.3 years, range, 40-86) with @entity1459 ( @entity1459 ) or @entity583 ( @entity583 ); 2) 31 consecutive @entity1 (25 @entity1 , 6 @entity1 ; mean age 64 +/- 12.7; range, 47-83, years) with signs and symptoms of clinically stable @entity453 . High-sensitivity- @entity1851 (hs-CRP) levels were determined with a commercially available enzyme-linked immunoassay method. In @entity1 with @entity1459 and @entity583 before reperfusion therapy, CRP levels were not significantly different to those in @entity1 with stable @entity453 (5.96 +/- 2.26 versus 4.35 +/- 2.6 mg/L; P = 0.12), but tended to be higher in @entity1 with @entity1459 and @entity583 . Baseline CRP levels in the subgroup of @entity1 with @entity583 (6.49 +/- 2.28 mg/L) were significantly higher than levels in @entity1 with stable @entity453 (4.35 +/- 2.6 mg/L; P = 0.02). CRP levels in @entity1 with @entity1459 and @entity583 were measured four times during a 72-hour period (0, 12, 24, and 72 hours). The lowest value was observed at baseline and differed significantly from values measured at any other time of the observation period (P < 0.001; 5.96 +/- 2.26; 9.5 +/- 9.04, 18.25 +/- 11.02; 20.25 +/- 10.61). CRP levels after 12, 24, and 72 hours were also significantly different to the initial values for @entity1 with stable @entity453 (P < 0.01). There was no correlation between CRP and @entity908 kinase (CK), CK-MB isoenzyme, or troponin I positivity as markers for the extent of the @entity296 during the observation period. Baseline levels of serum CRP tended to be higher in @entity1 with @entity1459 or @entity583 but were not significantly different from levels in @entity1 with chronic stable @entity453 . In the subgroup of @entity1 with @entity583 , baseline CRP levels were significantly higher than the levels in @entity1 with stable @entity453 . CRP as a marker of @entity32 is significantly increased in @entity1 with @entity583 and @entity1459 shortly after the onset of symptoms (after a period of 12 hours), supporting the hypothesis of an activation of inflammatory mechanisms in @entity1 with an @entity1187 or @entity583 .
