Low pericyte coverage of endometrial microvessels in heavy menstrual @entity548 correlates with the microvessel expression of XXXX .

@entity1 @entity548 @entity7 @entity190 @entity2100
A prospective clinical study was carried out to investigate whether endometrial microvessels in @entity1 with @entity548 (HMB) of endometrial origin (HMB-E) are fragile due to low pericyte coverage. Idiopathic HMB-E is characterized by large endothelial cell gaps related to the microvascular overexpression of @entity7 ( @entity7 )-A and @entity7 receptors  1-3. A total of 10  @entity1 with a normal menstrual cycle and a history of HMB of <5  years, and 17  healthy @entity1 with a normal menstrual cycle were recruited from the Karolinska University Hospital. Blood samples were obtained for hormone analysis and coagulation tests. Endometrial biopsies were collected in the proliferative or in the secretory phase. Pericyte coverage was assessed using immunohistochemical staining for smooth muscle actin-a  (SMAa) and by image analysis (microvascular density) of endometrial biopsies from 10  @entity1 with HMB-E and 17  healthy ovulating @entity1 (control subjects). Previously published data on endothelial cell gap size and the expression of @entity7 receptors were used. Although microvascular density did not differ between the @entity1 with HMB-E and the control subjects, the number of SMAa-positive microvessels in the proliferative phase was significantly (P=0.005) lower in the @entity1 with HMB-E than in the control subjects. Moreover, the number of SMAa-positive microvessels in the control subjects was significantly fewer in the secretory (P=0.04) than in the proliferative phase, whereas this number did not differ among the @entity1 with HMB-E regardless of phase. A significant negative correlation was observed between the number of @entity7 -positive microvessels and microvessels with pericyte coverage (r=0.8; P=0.04). Finally, the endothelial cell layer was significantly thicker in the @entity1 with HMB-E than in the control subjects. Thus, the upregulation of @entity7 in idiopathic HMB-E is associated with a low pericyte coverage during the proliferative phase of intense angiogenesis, which may confer @entity2100 , possibly leading to excessive @entity190 .
