Preoperative Breast @entity158 Predicts Persistent Breast XXXX and Disability After Breast Cancer Surgery.

@entity1 @entity5026 @entity1183 @entity158
CONTEXT: Approximately 30% of the @entity1 report @entity158 in the affected breast before breast cancer surgery. OBJECTIVES: The purpose of this secondary analysis of our prospective study was to determine how @entity1 who experienced both preoperative and persistent postsurgical @entity5026 (n=107) differed from @entity1 who did not report preoperative @entity5026 and did (n=158) or did not (n=122) experience persistent postsurgical @entity5026 . METHODS: Differences in demographic and clinical characteristics were evaluated. Linear mixed effects (LME) modeling was used to evaluate for group differences in symptom severity, function, sensation, and quality of life (QOL) over time. RESULTS: Between-group differences in demographic and clinical characteristics as well as trajectories of shoulder function and QOL were identified. @entity1 with both preoperative and persistent postsurgical @entity5026 were younger; were more likely to report swelling, strange sensations, hardness, and @entity1183 in the affected breast before surgery; and were more likely to have reconstruction at the time of surgery. @entity1 with both preoperative and persistent postsurgical @entity5026 had more biopsies in the prior year, more lymph nodes removed, and reported more severe acute postsurgical @entity158 than @entity1 without preoperative @entity5026 . The LME modeling revealed significant group effects for most outcomes evaluated. Over the six months of the study, @entity1 with both preoperative and persistent postsurgical @entity158 had persistently poorer shoulder flexion and physical well-being than @entity1 without preoperative @entity5026 . CONCLUSION: Investigations of the etiology and molecular mechanisms of preoperative @entity5026 , as well as interventions for this high-risk group, are needed.
