Endotherapy of early onset XXXX : results with long-term follow-up.

@entity1 @entity1689 @entity101 @entity158
BACKGROUND: @entity1689 that presents at age 35 years or younger has been classified as early onset type and is often characterized by chronic severe @entity158 . Endotherapy, with drainage of the main pancreatic duct, can lead to control of @entity158 if ductal @entity101 is an important cause. Long-term results of endotherapy in @entity1 with early onset @entity1689 are reported herein. METHODS: This retrospective study consists of 11 @entity1 (6 @entity1 , 5 @entity1 ; mean age 24.2 years, range 16-34 years) treated endoscopically in a 6.5-year period. The indication for treatment was @entity158 in all @entity1 and all had a dilated main pancreatic duct on pancreatography. The objectives of endoscopic treatment were to obtain good drainage of the pancreatic duct and complete clearance of ductal stones. RESULTS: Treatment was successful in all @entity1 with no procedure-related mortality and with mild complications. Seven @entity1 remained free of @entity158 relapses after a mean follow-up of 78.3 months (37-116 months). Seven relapses of @entity158 were recorded in the remaining 4 @entity1 . Endoscopic retreatment was successful in all cases. The difference between the number of hospitalizations during the year before treatment (mean 2.2, range 1-9) and the year after (mean 0.3, range 0-2) was statistically significant (p < 0.01). Statistical significance was maintained at 3 and 6 years' follow-up. CONCLUSIONS: Endoscopic treatment could be regarded as the initial management of choice for @entity1 with early onset @entity1689 .
