A randomised controlled trial of aerobic exercise after XXXX or minor @entity64 to prevent @entity73 : the MoveIT study protocol.

@entity1 @entity64 @entity303 @entity73 @entity4905
INTRODUCTION: @entity1 with @entity4905 ( @entity4905 ) or @entity64 are at risk for @entity73 and @entity303 . Currently, there is no known effective strategy to prevent this @entity73 . Increasing evidence exists that physical exercise is beneficial for cognitive function. However, in @entity1 with @entity4905 or @entity64 who are at risk of @entity73 and @entity303 , only a few trials have been conducted. In this study, we aim to investigate whether a physical exercise programme (MoveIT) can prevent @entity73 in @entity1 in the acute phase after a @entity4905 or minor @entity64 . METHODS AND ANALYSIS: A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care. 120 adult @entity1 with a @entity4905 or minor @entity64 than 1   month ago will be randomly allocated to an exercise programme consisting of a 12-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the period of 1   year or to usual care. Outcome measures will be assessed at the baseline, and at the 1-year and 2-year follow-up. The primary outcome is cognitive functioning measured with the Montreal Cognitive Assessment (MoCA) test and with additional neuropsychological tests. Secondary outcomes include maximal exercise capacity, self-reported physical activity and measures of secondary prevention. ETHICS AND DISSEMINATION: The study received ethical approval from the VU University Amsterdam Ethics committee (2011/383). The results of this study will be published in peer-reviewed journals and presented at international conferences. We will also disseminate the main results to our @entity1 in a letter. TRIAL REGISTRATION NUMBER: The Nederlands Trial Register NTR3884.
