[Experimental examinations and toxicokinetic analysis of the absorption and excretion of XXXX by the lung].

@entity235 @entity9537 @entity12783
Of fifteen @entity235 each five of them inhaled @entity9537 ( @entity12783 ) at the levels of 700, 1500 and 2,000 ppm respectively for one hour. Changes in @entity12783 concentrations in the expired air, arterial blood and venous blood of @entity235 were measured from the beginning of exposure until one hour after the end of exposure. The results obtained were as follows. 1. Cumulative uptakes of @entity12783 in one hour exposure were 27.3 mg/kg at 700 ppm, 44.7 mg/kg at 1,500 ppm and 71.2 mg/kg at 2,000 ppm. 2. Excretion ratios of @entity12783 in one hour after the exposure were 66-71% at all the three levels of exposure. 3. During the exposure, highly significant negative correlation was seen between arterial/venous blood concentration ratio and expired/inspired air concentration ratio. In the post-exposure period, highly significant positive correlations were seen between expired air concentration and venous or arterial blood concentration. 4. The mean ratio of the total absorption value to the total inspired value was 14% at all the three levels of exposure. 5. From these results, the authors examined the multiple regression equations with two independent variables x and z which are shown as follows. a) During the exposure period, Y1: Cumulative absorption solvent value by the @entity235 (mg/kg) X1: Time of exposure (min) Z1: Level of the solvent value in the ambient air (microgram/ml) log Y1 = -0.526 + 0.622 log X1 + 0.905 log Z1 b) Post exposure period, Y2: Cumulative excreted solvent value by the @entity235 (mg/kg) X2: Time after the end of exposure (min) Z2: Cumulative absorbed solvent value by the @entity235 at the end of exposure (mg/kg) log Y2 = -2.300 + 0.609 log X2 + 0.858 log Z2 We assumed that both equations are very fit and significant.
