Treatment and prevention of XXXX using a new combination of topicals: 30 cases report.

@entity1 @entity15735 @entity3675 @entity3408 @entity5806 @entity9252 @entity2348 @entity9759 @entity7553 @entity1909
BACKGROUND: Moderate and chronic @entity9252 is a common disease affecting the hand. Treatment can be effective but the affection is often recurrent, especially as an @entity3675 . Also, this condition may be complicated by a Candida s pp or @entity2348 . Therefore, general preventive measures can be useful in maintaining healing. OBJECTIVE: T he aim of this study was to investigate the e fficacy and tolerability of a new combination of topical medications in the treatment and prevention of moderate and chronic @entity9252 . This formulation includes an insulating polymer ( @entity15735 -cell barrier), two topical antifungals (octopirox and climbazole) and a molecule with anti-inflammatory activity (Corticoid - like Repair). @entity1 AND METHODS: 30 adult subjects (age, 16--78 years; 24 females and 6 males) affected by moderate or chronic @entity9252 with or without nail alterations associated were evaluated. Included in the study were @entity1 with @entity3408 (8); @entity9759 (19); psoriatic @entity9252 (2 @entity1 ); @entity5806 (1 @entity1 ). Sometimes Candida spp or bacteria overlap with @entity9252 (16 @entity1 positive for Candida spp and 4 @entity1 with @entity2348 ), sometimes infectious @entity9252 was not associated with @entity1909 of the hands. All 30 subjects were treated with a new formulation of cream, three applications per day for 2 months. In 8 @entity1 with proven and severe @entity7553 of the nails was added oral fluconazole 100 mg for 20 days. All @entity1 with @entity2348 have taken clarithromycin 500 mg twice daily for six days. @entity1 were then followed for 8 weeks . RESULTS: After two months of treatment, 26 @entity1 responded to therapy. In particular, the treatment evaluation at the end of the follow--up period showed a clinical cure in 46,6 % (14 @entity1 ), improvement in 40 % (12 @entity1 ), and failure in 13,4% (4 @entity1 ). There was a side effect in 2 @entity1 of moderate skin irritation, but the drug was not discontinued. CONCLUSIONS: Results of the present study, based on its safety, effectiveness and i nnovative features, indicate that t his combination of topical cream may be considered as a new alternative for treatment and prevention of @entity9252 , especially in case of @entity3675 where prolonged treatment and continuous prevention are needed.
