Response to starvation of hepatic XXXX palmitoyltransferase activity and its regulation by @entity1285 . Sex differences and effects of pregnancy.

@entity844 @entity6211 @entity1285 @entity35 @entity11668
1. Hepatic @entity6211 palmitoyltransferase activity was measured over a range of concentrations of @entity11668 and in the presence of several concentrations of the inhibitor @entity1285 . These measurements were made in mitochondria obtained from the livers of fed and starved (24 h) virgin female and fed and starved pregnant @entity35 . 2. In the fed state overt @entity6211 palmitoyltransferase activity was significantly lower in virgin females than in age-matched male @entity35 . 3. Starvation increased overt @entity6211 palmitoyltransferase activity in both virgin and pregnant females. This increase was larger than in the male and was greater in pregnant than in virgin females. 4. In the fed state pregnancy had no effect on the Hill coefficient or the [S]0.5 when @entity11668 was varied as substrate. Pregnancy did not alter the sensitivity of the enzyme to inhibition by @entity1285 . 5. Starvation decreased the sensitivity of the enzyme to @entity1285 . The change in sensitivity was similar in male, virgin female and pregnant @entity35 . 6. The possible relevance of these findings to known sex differences and changes with pregnancy in hepatic @entity844 oxidation and esterification are discussed.
