[The study of peptide vaccine HDS from XXXX glucosyltransferase].

@entity6586 @entity1547 @entity35
OBJECTIVE: To investigate the antigenicity of the peptide vaccine HDS from @entity6586 glucosyltransferase and its ability to induce protective immune responses in an experimental @entity35 model of @entity1547 . METHODS: Artificial antigen HDS-KLH, peptide HDS, glycosyltransferase were injected to immunize @entity35 . Measurement of the specific anti-HDS, GTF IgG or IgA concentration in saliva and serum were undertaken by ELISA among the experimental groups. Gnotobiotic @entity35 model was developed when challenged @entity6586 and a caries promoting diet. The jaws of the @entity35 were selected and dyed. The Keyes caries score for each jaw were counted. RESULTS: The level of serum and salivary specific anti-HDS IgG and IgA in the group immunized by HDS-KLH was significantly higher than that in control group (P < 0.05). The Keyes caries score of GTF, HDS and HDS-KLH immunized group were significantly lower than that of control group, especially lower in smooth tooth surface. CONCLUSION: Artificial antigen HDS-KLH could induce immune response. As a peptide vaccine, HDS-KLH could reduce the caries incidence in experimental @entity35 model.
