Factors associated with oxidative stress in XXXX populations.

@entity1 @entity2066 @entity620 @entity1234 @entity10329 @entity165 @entity1851
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in @entity1 and the demographic, physical, or nutritional factors that may be associated with it. Such information is essential for the design and analysis of studies investigating the role of oxidative stress in health and disease. This paper presents data on levels of two biomarkers of lipid peroxidation, @entity1234 and F(2)- @entity10329 , in 298 healthy adults aged 19-78 years. The study was conducted in Berkeley and Oakland, California, in 1998-1999. Sex was the strongest predictor of lipid peroxidation as measured by both biomarkers (p < 0.0001); it was stronger than smoking. @entity1851 was positively associated with lipid peroxidation (p = 0.004), as was plasma @entity165 . Plasma @entity620 had a strong inverse relation (p < 0.001) with both biomarkers. Plasma @entity2066 was also associated with F(2)- @entity10329 . Other plasma antioxidants were not associated with lipid peroxidation biomarkers, once @entity620 was included in the multivariate model. Future surveys and epidemiologic studies should measure at least one marker of oxidative damage, as well as plasma @entity620 . These data would permit a better understanding of the role that oxidants and antioxidants play in the health of @entity1 populations.
