Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with @entity3003 in the treatment of XXXX .

@entity1 @entity3003 @entity137 @entity43
PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the continuous heating and circulation of chemotherapy throughout the abdominal cavity in an attempt to enhance @entity137 . Despite the potential of this chemotherapy procedure, there are scant anatomical temperature distribution studies reporting on this therapeutic process. @entity1 AND METHODS: We prospectively evaluated the temperature of select anatomical (e.g. upper abdominal, mid-abdominal and supra-pubic) sites in 11 advanced stage @entity43 @entity1 who were treated with consolidation HIPEC @entity3003 (AUC 10). The temperature of the aforementioned anatomical regions and the inflow/outflow tubing was measured at baseline and at 15-min intervals until the procedure's completion. RESULTS: The lowest observed mean composite temperature was 41.1     C at the supra-pubic site whereas the highest temperature was 42.6     C, in association with the inflow/outflow tubing. During the various time intervals we also ascertained that the lowest composite temperature was 40.9     C at baseline (i.e. time 0), whereas the highest value (41.8     C) occurred at multiple time periods (e.g. 15, 45 and 60   min). CONCLUSION: The HIPEC temperature variation amongst the various abdominal sites and time intervals was minimal. We also discerned that uniform temperature distribution throughout the abdominal cavity was facilitated when the abdomen was both maximally distended with fluid and a high flow rate was maintained.
