Malignant predominantly minigemistocytic @entity11 in two @entity1 : a distinctive XXXX variant?

@entity1 @entity455 @entity39 @entity5 @entity538 @entity4483 @entity11
We report unusual distinctive histopathological features in @entity5 of two @entity1 ( @entity1 1: congenital, @entity1 2: 30 months). Both @entity1 had paraventricularly located well-delineated @entity5 . Gross total resection could be performed and postoperative chemotherapy was administered. At the last follow-up, 18 ( @entity1 1) and 10 months ( @entity1 2) postoperatively, both @entity1 were in continuous complete remission. Histologically, both @entity5 were characterized by high cellular density and monomorphic appearance. @entity5 cells were small to medium-sized and the majority of cells showed a distinctive minigemistocytic shape. A small fraction of cells lacked a distinct cytoplasm. Mitotic figures were abundant, @entity5 @entity39 and @entity455 were absent. Immunohistochemically, the @entity5 cells expressed glial ( @entity538 , @entity4483 ) and focally neuronal (NFP) proteins. Comparative genomic hybridization showed few, dissimilar @entity5 . Although sharp demarcation and monomorphic @entity5 are reminiscent of a primitive @entity5 , cytological and immunohistochemical glial differentiation refer to a @entity5 origin. To our knowledge the histopathological features of the described @entity5 do not correspond unequivocally to any @entity11 variant and could represent a distinctive new @entity11 subtype.
