Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal XXXX .

@entity1 @entity4105 @entity2880 @entity21909 @entity1851
OBJECTIVE: To study the effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity. DESIGN: Prospective, randomized, controlled study. SETTING: Academic hospital. @entity1 (S): Healthy postmenopausal @entity1 with an intact uterus. INTERVENTION(S): For the first 12 months, the hormone replacement therapy group (n = 14) received oral E2, 1 mg daily, sequentially combined with 5 or 10 mg of @entity21909 . Thereafter, they received oral E2, 2 mg daily, sequentially combined with 10 mg of @entity21909 . The control group (n = 13) received no treatment. Data were collected at baseline and at 3, 12, and 15 months. MAIN OUTCOME MEASURE(S): Parameters of endothelial function and inflammatory activity. RESULT(S): During 12 months of follow-up, we observed decreases of 15% in plasma levels of endothelin-l, of 21% in soluble thrombomodulin, of 14% in @entity2880 factor, and of 12% in clottable fibrinogen in the hormone replacement therapy group compared with the control group. There was a 5% decrease in soluble @entity4105 tevels. All significant changes were observed by 3 months and sustained after 15 months. Brachial artery flow-mediated vasodilatation and @entity1851 levels did not change significantly. CONCLUSION(S): Long-term combined hormone replacement therapy with E2 and @entity21909 in healthy @entity1 was associated with sustained improvement in some aspects of endothelial function and in clottable fibrinogen levels.
