Influences of the common @entity18957 XXXX variant on inflammatory markers throughout a broad range of body mass index.

@entity18956 @entity18957 @entity1 @entity650 @entity28 @entity1356 @entity310 @entity10557 @entity12868 @entity8923 @entity2533 @entity688 @entity1386 @entity1851
BACKGROUND: A recent study reported that the @entity1386 associated A-allele of @entity18957 @entity18956 increased plasma high sensitivity @entity1851 (hs-CRP) levels independent of @entity1386 . We aimed to investigate if this gene variant had @entity1386 -independent effects on plasma hs-CRP and 10 additional circulating @entity28 -related adipokines throughout a broad range of body mass index (BMI) among Danish @entity1 . METHODOLOGY/PRINCIPAL FINDINGS: In a population of 362,200 young @entity1 , examined for military service between 1943 and 1977, two groups were identified: 1) a random 1% sample and 2) all @entity28 @entity1 (BMI=31.0 kg/m(2), all of whom were above the 99(th) percentile of this population). At an average age of 49 years (range: 39 through 65 years), 551 @entity1 , hereof 231 of the @entity28 , were re-examined, including genotyping and measurement of the fasting circulating inflammatory markers hs-CRP, @entity1356 , @entity650 , @entity688 , @entity8923 , @entity10557 , @entity12868 , sTNFa-R1, @entity2533 , @entity310 and leptin. @entity1 with known disease were excluded from the examination. All the inflammatory markers were log-transformed to approximate a normal distribution. Genotype-phenotype relationships were studied using linear regression analyses with the inflammatory markers as the response variable. Significant positive associations between hs-CRP, leptin and a broad range of BMI were observed, but the associations did not significantly differ across @entity18957 @entity18956 genotype. There were no significant associations between the other inflammatory markers, @entity18957 @entity18956 genotype or BMI, respectively. CONCLUSION: No @entity1386 -independent effects of the @entity18957 @entity18956 A-allele on a series of inflammatory markers were observed in this cohort of healthy middle-aged @entity1 representing a broad range of @entity1386 .
