Plasma Inflammatory Factors Are Associated with @entity148 , @entity308 , and Cognitive Problems in Adults with and without XXXX Dependence: An Exploratory Protein Array Study.

@entity1 @entity308 @entity888 @entity146 @entity73 @entity148 @entity2414 @entity734
OBJECTIVES: It is hypothesized that immune factors influence @entity146 and contribute to relapse. The primary study objectives were to (1) compare @entity146 across adults with active @entity888 (MA) dependence, in early remission from @entity734 , and with no history of @entity734 , (2) determine whether active or recent @entity734 affects the expression of immune factors, and (3) evaluate the association between immune factor levels and @entity146 . METHODS: A cross-sectional study was conducted using between group comparisons and regression analyses to investigate associations among variables. Eighty-four adults were recruited into control (CTL) (n   =   31), MA-active (n   =   17), or MA-remission (n   =   36) groups. @entity1 completed self-report measures of @entity148 , @entity308 and objective tests of attention and executive function. Blood samples were collected, and a panel of immune factors was measured using multiplex technology. RESULTS: Relative to CTLs, MA-dependent adults evidenced greater @entity148 and @entity308 during active use (p   <   0.001) and remission (p   <   0.007), and more attention, memory, and executive problems during remission (p   <   0.01) but not active dependence. Regression analyses identified 10 immune factors (putatively associated with cytokine-cytokine receptor interactions) associated with @entity148 , @entity308 , and @entity2414 . CONCLUSION: While psychiatric symptoms are present during active @entity734 and remission, at least some @entity73 emerge only during remission. Altered expression of a network of immune factors contributes to neuropsychiatric symptom severity.
