Effects of dietary conjugated XXXX at high-fat levels on @entity1674 regulation in @entity19 .

@entity19 @entity1674 @entity409 @entity4336 @entity2041 @entity3986 @entity382 @entity13357 @entity4722
OBJECTIVE: Our aim was to investigate the effects of dietary conjugated @entity4722 (CLA) at high-fat (HF) levels on parameters related to @entity1674 (TG) regulation and some potential impacts on @entity409 . METHODS: Growing @entity19 were fed a control diet (7% @entity4336 oil), an HF diet containing 20% @entity4336 oil, or an HF diet containing 3% CLA (HF + CLA) for 30 d. Tissue and organ weights, plasma and tissue TG levels, and parameters related to their regulation were evaluated. Liver oxidative status was also assessed. RESULTS: Dietary CLA showed detrimental and beneficial effects. CLA added to the HF diet caused @entity382 (+32%) and exacerbated the hepatic TG accumulation (+168%) observed with the HF diet without inducing @entity409 ; however, it significantly reduced plasma TG concentrations (-37%) and normalized muscular TG content. An increase in @entity2041 was associated with total normalization of liver lipid peroxidation. In addition, HF + @entity13357 caused @entity3986 of epididymal fat pads, even when the HF diet had increased the adipose tissue mass (30%). The biochemical mechanisms involved in the regulation of lipid levels were related to reduced (-20%) hepatic very low-density lipoprotein-TG secretion and decreased muscle (-35%) and adipose (-49%) tissue contributions to the removal of plasma TG by lipoprotein lipase enzymes. CONCLUSION: Examination of CLA at HF levels showed @entity382 and exacerbation of lipid accretion as a negative impact; however, some positive aspects such as hypotriglyceridemia and protection against oxidative stress were also induced. Even the fat reduction is nutritionally important for weight control; the biochemical mechanisms whereby CLA mediates the potential effects could produce undesirable metabolic alterations.
