Evaluation of @entity6170 administration on cardiovascular function in severe XXXX .

@entity1 @entity28 @entity4 @entity2690 @entity6170 @entity413
BACKGROUND: Obese @entity1 have myocardial structural and functional alterations related to @entity2690 resistance. HYPOTHESIS: The purpose of the study was to analyze the effects of @entity6170 , an @entity2690 sensitizer agent, on cardiac morphometry and functioning. METHODS: In 2 groups of sex- and age-matched, nondiabetic, @entity28 @entity1 (5 @entity1 and 7 @entity1 , age 19-51 y; group A: body mass index [BMI] 40.6 +/- 3.4 kg/m(2); group B: BMI 42.6 +/- 2.7 kg/m(2)), we evaluated the basal @entity2690 sensitivity index (HOMA[IS]), body composition by bioelectrical impedance analysis and 24-h blood pressure monitoring. Furthermore, all @entity1 underwent conventional 2-Dimensional and color Doppler echocardiography, and pulsed-wave tissue Doppler imaging (TDI). After the baseline evaluation, all @entity1 were put on a hypocaloric diet (70% basal metabolic rate) plus placebo if they were in group A, or plus @entity6170 (4 mg twice daily; Avandia [GlaxoSmithKline plc., Brentford, Middlesex, United Kingdom]) if they were in group B, for 6 mo. RESULTS: Significant decreases in body weight, total fat mass, BMI, and systolic blood pressure were registered in both groups. @entity6170 administration appeared more efficient in improving HOMA(IS) (mean difference: 0.30 +/- 0.19 versus 0.11 +/- 0.21, p < 0.05). Left ventricular (LV) diastolic diameter (49.4 +/- 7.7 versus 52.3 +/- 5.4 mm, p < 0.05) and E wave (0.89 +/- 0.18 versus 0.99 +/- 0.20 m/sec, p < 0.05) increased in the @entity6170 group due to a rise in preload and water content without peripheral @entity4 . The increase in systolic (Sa) wave velocity in both groups was probably a result of the general improvement in @entity2690 metabolism and the decrease in blood pressure. CONCLUSIONS: We confirmed the positive effect of @entity6170 on @entity413 metabolism in @entity28 , nondiabetic @entity1 , but changes in @entity2690 sensitivity did not explain the cardiac effects produced by further mechanisms.
