Changes in the intestinal enzyme activity of @entity742 during @entity281 with XXXX .

@entity742 @entity1160 @entity368 @entity908 @entity16 @entity36993 @entity281 @entity5911 @entity880 @entity39350 @entity224
The pathology and enzymology of the intestinal mucosae of @entity742 dosed daily with 2500 @entity36993 larvae and killed at five, nine or 14 weeks were compared with worm-free animals. The proximal small intestines of the infected @entity742 exhibited extensive @entity16 at five and nine weeks, but only isolated lesions were found at 14 weeks. Activities of the brush border enzymes alkaline phosphatase, @entity368 amino-peptidase, maltase and @entity39350 dipeptidase were all significantly depleted during @entity281 , although the magnitude, time of onset and duration of the individual enzyme responses varied. Mucosal activities of the pancreatic enzymes, trypsin and to a lesser extent chymotrypsin were also markedly decreased particularly during the first nine weeks of @entity281 . Specific acetylcholinesterase activity was significantly increased throughout the study, maximal levels being observed at five weeks. In contrast 'pseudo'-cholinesterase levels were consistently within the control range. During the early stages of @entity281 (five weeks) @entity1160 - @entity5911 transaminase activity was significantly decreased, while aldolase and @entity908 phosphokinase levels were significantly elevated. At nine weeks low @entity1160 - @entity5911 transaminase activities were again detected and @entity880 dehydrogenase activity was also markedly reduced. At 14 weeks the mean activities of all four enzymes were within the normal range as were @entity224 dismutase levels throughout. Significant correlations were found between alkaline phosphatase, trypsin, chymotrypsin, aldolase and @entity1160 - @entity5911 transaminase activities and the degree of @entity16 within the individual @entity742 .
