A @entity1 XXXX expressed in @entity19 stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to @entity1 @entity2841 .

@entity2304 @entity1 @entity14190 @entity2841 @entity19 @entity3019 @entity10734 @entity7522
@entity2304 ( @entity2304 ) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by @entity10734 ( @entity10734 ) have been extensively characterized, the roles of @entity10734 signals in differentiation have remained to be elucidated. To examine the relationship between receptor expression and differentiation of hemopoietic cells, we used @entity19 (Tg- @entity19 ) that constitutively express @entity1 (h) @entity10734 at almost all stages of hemopoietic cell development. Proliferation and differentiation of hemopoietic progenitors in bone marrow cells from these Tg- @entity19 were analyzed by @entity7522 colony formation assay. High affinity @entity10734 interacts with @entity2304 in a species-specific manner, therefore one can analyze the effects of hGMR signals on differentiation of @entity19 hemopoietic progenitors using @entity2841 . Although @entity19 (m) @entity2304 yielded only GM colonies, @entity2841 supported various types of colonies including GM, eosinophil, mast cell, erythrocyte, megakaryocyte, blast cell, and mixed hemopoietic colonies. Thus, the effects of @entity2841 on colony formation more closely resembled @entity3019 than those of mGM-CSF. In addition, @entity2841 generated a much larger number of blast cell colonies and mixed cell colonies than did @entity3019 . @entity2841 also generated erythrocyte colonies in the absence of @entity14190 . Therefore, @entity2304 apparently has the capacity to promote growth of cells of almost all hemopoietic cell lineages, if functional hGMR is present.
