Increased levels of a 21-kDa protein in the circulation of @entity5 -bearing XXXX .

@entity1 @entity706 @entity5 @entity1067 @entity3544 @entity1358 @entity1820
A novel non-ras 21-kDa protein ( @entity3544 ) was detected in sera of @entity5 @entity1 by enzyme-linked immunosorbent assay (ELISA), using polyclonal anti- @entity3544 antibodies. While only 4.6% of the healthy donors (n = 43) showed @entity3544 serum levels higher than the mean +/- 2 SD of the normal group, 33 to 80% of the @entity5 @entity1 (n = 94) with @entity5 were positive in the ELISA test. In particular, @entity1 with @entity706 , urogenital, and @entity1820 had a 2.8- to ninefold increase in @entity3544 serum levels. Elevated serum levels were also found in @entity1 with @entity1067 (3.2-fold increase). In 17 out of 22 @entity1 with @entity5 , changes in serum @entity3544 levels correlated with the clinical course of the disease. In 15 @entity1 , a favorable response to therapy was correlated with a decline in serum @entity3544 level. Two @entity1 with @entity1358 showed increased or persistently high levels of @entity3544 after surgery and were subsequently found to have distant metastases. Expression of @entity3544 in ten @entity1358 tissues was determined by Western blotting. There was a trend toward a higher content of @entity3544 in the less-differentiated @entity5 tissues. In conclusion, @entity3544 may be a useful indicator in monitoring the outcome of treatment in @entity1 with various @entity5 . In @entity1 with @entity1358 , @entity3544 serum levels may be of particular importance because no other @entity5 marker is available.
