Identification of @entity16051 , @entity6472 , and @entity5840 in head and XXXX .

@entity1 @entity5 @entity167 @entity213 @entity957 @entity1544 @entity6472 @entity16051 @entity5840
BACKGROUND: Certain @entity5 antigens have been identified that stimulate an immune response, thus making them targets for immunotherapy. @entity16051 , @entity6472 , and @entity5840 are such antigens. This study was undertaken to determine their presence or absence in head and neck @entity1544 and to correlate this with @entity1 characteristics. METHODS: Reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry (IH) were used to identify @entity16051 , @entity6472 , and @entity5840 in surgical specimens. @entity1 data (previous treatment, gender, age, primary site, metastasis, @entity5 grade, @entity5 stage, smoking history, and @entity167 history) were collected by chart review and examined for correlation with presence or absence of antigen. RESULTS: Three @entity5 were found to be positive for @entity16051 by RT-PCR. All of these @entity5 were also positive for @entity6472 and @entity5840 . IH was only positive for @entity16051 in one @entity1 . Eighteen of the 45 @entity5 (40%) were positive for @entity6472 by RT-PCR. By IH, only six @entity5 were positive for @entity6472 . Five (83.3%) of those that were positive by IH were positive by RT-PCR. Twenty of the 45 @entity5 (44.4%) were positive for @entity5840 by RT-PCR. By IH, 12 @entity5 were positive for @entity5840 . Nine (75%) of those positive by IH were also positive by RT-PCR. Overall, of the 45 @entity5 , 27 (60%) were positive by RT-PCR for at least one of the antigens. None of the @entity1 characteristics correlated with the presence or absence of antigen. CONCLUSIONS: There is high expression of @entity6472 and @entity5840 antigens in @entity213 , whereas @entity16051 is not significantly expressed. IH correlates but is not as sensitive as RT-PCR for detection of these antigens. There is no correlation between antigen expression and @entity1 data. On the basis of the high levels of @entity6472 and @entity5840 expression, use of these antigens may serve as a potential approach to immunotherapy for @entity957 from head and neck sources.
