Study of Cysteine-Rich Protein 61 Genetic Polymorphism in Predisposition to XXXX : A Case Control.

@entity1 @entity73 @entity174 @entity39368
Background. Many factors are responsible for this @entity73 , especially in long bones, but a possible genetic predisposition for the development of this complication remains unknown till now. In the present study, we aim to examine the @entity39368 gene polymorphism in @entity174 nonunion @entity1 and the correlation with clinical findings. Materials and Methods. We performed SNP analysis of the @entity39368 gene in 250 @entity174 nonunion @entity1 and 250 healthy subjects were genotyped in this hospital-based case control study, and 56 cases were further evaluated for mRNA expression of @entity39368 by real-time quantitative reverse-transcription PCR. Results. @entity39368 gene TT, TG, and GG genotype frequencies of total @entity174 nonunion cases were 41.6%, 49.2%, and 9.20% and 54.4%, 39.2%, and 6.40% in healthy controls. Heterozygous TG genotype was found statistically significant in @entity174 nonunion cases compared with that in controls, whereas homozygous mutant GG genotype was not found significant. Moreover, we found that TG + GG genotypes were significantly different in serum expression of @entity39368 mRNA when compared with cases (TT genotypes). Conclusions. Our result signifies that genotype of @entity39368 affects the mRNA expression and acts as a risk factor that could synergistically increase the susceptibility of a @entity1 to develop @entity174 nonunion.
