Probiotic XXXX Kluyveromyces marxianus CIDCA 8154 shows anti-inflammatory and anti-oxidative stress properties in in vivo models.

@entity2199 @entity19 @entity26 @entity27593 @entity29 @entity1959 @entity1960 @entity7625 @entity375
UNASSIGNED: @entity29 ( @entity29 ) are complex affections with increasing incidence worldwide. Multiple factors are involved in the development and maintenance of the symptoms including enhanced oxidative stress in intestinal mucosa. The conventional therapeutic approaches for @entity29 are based on the use anti-inflammatory drugs with important collateral effects and partial efficacy. In the present work we tested the anti-inflammatory capacity of Kluyveromyces marxianus CIDCA 8154 in different models. In vitro, we showed that the pretreatment of epithelial cells with the @entity375 reduce the levels of intracellular reactive @entity26 species. Furthermore, in a @entity19 model of @entity1959 -induced @entity1960 , @entity375 -treated animals showed a reduced histopathological score (P<0.05) and lower levels of circulating interleukin 6 (P<0.05). The capacity to modulate oxidative stress in vivo was assessed using a @entity2199 model. The @entity375 was able to protect the @entity2199 from oxidative stress by modulating the @entity27593 transcription factor trough the @entity7625 pathway. These results indicate that K. marxianus CIDCA 8154 could control the intestinal inflammation and cellular oxidative stress. Deciphering the mechanisms of action of different probiotics might be useful for the rational formulation of polymicrobial products containing microorganisms targeting different anti-inflammatory pathways.
