High anabolic potential of essential XXXX mixtures in advanced @entity1149 .

@entity1 @entity3534 @entity368 @entity5 @entity1149 @entity2057 @entity3689 @entity121 @entity5653
BACKGROUND: Conventional nutritional supplements are not or only partly successful in inducing protein accretion in @entity5 , suggesting an attenuated anabolic response. To prevent @entity2057 and its deleterious consequences, generating an anabolic response is crucial. Dietary essential @entity3534 (EAA) have anabolic properties in other @entity5653 ; however, data in @entity5 are lacking. @entity1 AND METHODS: In 13 @entity1 with @entity1149 ( @entity1149 ) (stage III and IV) and 11 healthy age-matched subjects, we measured protein synthesis and breakdown of the whole body, and net protein anabolism (difference between protein synthesis and breakdown) after intake of 14 g of free EAA with high @entity368 levels (EAA/ @entity368 ) versus a balanced @entity3689 mixture containing both EAA and non-EAA as present in whey protein, according to a randomized, double-blind, crossover design. RESULTS: Protein synthesis and net protein anabolism were higher after intake of the EAA/ @entity368 than the balanced @entity3689 mixture (P < 0.001), independent of presence of @entity5 . A highly significant linear relationship between net protein anabolism and the amount of EAA available in the systemic circulation (R(2): 0.85, P < 0.001) was found in both groups. The presence of muscle or recent weight loss, systemic inflammatory response, or length of survival did not influence this relationship. High @entity368 levels in the EAA/ @entity368 mixture was of no anabolic benefit. CONCLUSIONS: There is no anabolic resistance or attenuated anabolic potential to intake of 14 g of EAA/ @entity368 or balanced @entity3689 mixture in advanced (mainly stage III) @entity1149 . The high anabolic potential of dietary EAA in @entity5 @entity1 is independent of their nutritional status, systemic inflammatory response or disease trajectory, suggesting a key role of EAA in new nutritional approaches to prevent @entity121 , thereby improving outcome of @entity1 with @entity5 . CLINICALTRAILSGOV: NCT01172314.
