Growth inhibition and induction of apoptosis in MCF-7 XXXX cells by fermented soy milk.

@entity1 @entity8139 @entity0 @entity5532 @entity670 @entity19 @entity5 @entity26 @entity3230 @entity6400
The effect of a fermented soy milk product (FSP) on various @entity1 @entity0 cell lines was investigated, and it was shown to have a growth-inhibitory effect, especially on MCF-7 cells. Thus the MCF-7 cell line was used to study the mechanism of action. In female severe combined @entity3230 @entity19 implanted with MCF-7 cells, pretreatment with FSP significantly inhibited @entity5 growth. The inhibitory effect of FSP on MCF-7 cells seemed to be caused by the additive effects of a wide variety of constituents. The active components of FSP are mainly in the water phase, and the lipid-soluble fraction, which includes the soy @entity6400 such as @entity670 and @entity8139 , is relatively ineffective. A variety of methods were used to demonstrate that FSP caused apoptotic cell death in MCF-7 cells. FSP induced generation of reactive @entity26 species (ROS). Growth inhibition and ROS generation induced by FSP could be inhibited by catalase and @entity5532 , indicating that the ROS production probably was the cause of this apoptotic cell death. This study suggests that @entity5 growth in vivo and can trigger apoptosis in vitro. It may, therefore, be a potential nutritional supplement in chemotherapy.
