Is the @entity52586 polymorphism in the @entity4283 gene relevant to XXXX and the personality trait psychoticism?

@entity1 @entity32 @entity4483 @entity71977 @entity32983 @entity161 @entity4283 @entity52586
BACKGROUND: The @entity4283 ( @entity4283 ) is the main receptor for @entity4483 , an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of @entity161 . To further elucidate the possible relevance of @entity32 for mental functions, we investigated a functional polymorphism in the gene coding for @entity4283 in relation to personality traits and susceptibility to @entity161 . METHODS: We studied the @entity52586 polymorphism ( @entity32983 , @entity71977 ) in 2 population-based cohorts of middle-aged @entity1 assessed using the Karolinska Scales of Personality. In addition, we compared genotype frequencies between @entity1 with @entity161 and controls. RESULTS: The population-based cohorts included 270 @entity1 and 247 @entity1 , and the case-control study involved 138 @entity1 with @entity161 and 258 controls. In the population-based cohorts, 82Ser carriers were found to have significantly higher scores for the psychoticism personality trait comprising the detachment and suspicion subscales. The case-control study revealed that the 82Ser allele was significantly more frequent among @entity1 than controls. LIMITATIONS: This study was limited by the modest sample size and the use of a self-report measure to assess personality traits. CONCLUSION: Our findings suggest that the proven relation between certain personality traits and @entity161 can at least to some extent be explained on a genetic level. Also, the activated @entity4483 - @entity4283 axis may be an underlying cause, not only a consequence, of the disease.
