Objective assessment of foot strike in XXXX *.

@entity1 @entity18776 @entity3034 @entity304 @entity191 @entity6250 @entity676
We assessed the nature of foot strike and the potential effect of acute @entity3034 dosing in @entity191 @entity1 with mild to severe fluctuations of motor performances in comparison with healthy volunteers. Forty-eight @entity1 were enrolled in the study and compared with 33 age and gender matched controls. Each @entity1 was assessed by a computerized electropodographic system before @entity3034 dosing @entity676 -h after intake of a standard fasting morning dose of @entity3034 plus @entity18776 . Twelve foot strikes (six right, six left) were analysed per @entity1 . The controls underwent three repeated examinations at 1-h intervals. @entity1 ' motor response to acute @entity3034 dosing was evaluated at fixed times by a battery of motor tests. Foot strike dynamics differed between @entity1 and controls: in particular, first ground contact of the foot was significantly shifted from heel to forefoot in @entity1 compared to controls. The forward shift in footprint during walking was more marked on the more affected body side but was unrelated to the severity and duration of @entity304 and unresponsive to @entity3034 dosing. Tapping and walking tests were overall responsive to acute @entity3034 intake. The system seemed suitable to detect irregular patterns of foot strike even at the early stages of @entity304 , when @entity6250 was not clinically overt, and might be useful in the search for clinical markers of @entity191 .
