Expression of @entity22180 /phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical XXXX .

@entity1 @entity14705 @entity22180 @entity19 @entity1373 @entity8286 @entity3594 @entity1185 @entity189 @entity6354 @entity6881 @entity105
@entity22180 (EF), a growth factor modulator, is the @entity19 homologue of @entity1 secretory group II phospholipase A(2). EF exhibits growth-promoting activity in vitro, in the presence of @entity6354 , and also brings about phenotypic transformation of normal cells. In order to ascertain the role of EF in vivo, a @entity1 @entity6881 promoter was used to drive the expression of EF ectopically to squamous epithelial cells. The founder @entity19 and its progeny showed abnormal whiskers and a scaly, beaded tail. In these @entity19 , keratinization pattern of the epidermis was disturbed and @entity8286 and @entity3594 were noted. The @entity19 , TgK14-EF, expressed EF in the suprabasal layers of tail epidermis as well as in the epithelial cells of hair follicle and sebaceous glands of skin. Expression of EF along with @entity1373 was also observed in other @entity14705 and oesophagus. TgK14-EF @entity19 homozygous for the transgene showed delayed and scanty hair growth although the @entity19 were healthy and fertile. The hemizygous TgK14-EF @entity19 were sensitive to a two-stage chemical @entity105 and developed a higher number of @entity1185 than their normal littermates over the course of the experiment. The conversion rate of @entity1185 to @entity189 was two fold higher in the @entity19 .
