Evaluation of a home-based exercise program in the treatment of XXXX : the Maximizing Independence in Dementia (MIND) study.

@entity1 @entity308 @entity146 @entity195
OBJECTIVE: To determine the feasibility and efficacy of a home-based exercise intervention program to improve the functional performance of @entity1 with @entity195 ( @entity195 ). METHODS: Twenty-seven home-dwelling @entity1 with @entity195 were randomized to either an exercise intervention program delivered by their caregivers or a home safety assessment control. Measures of functional performance (primary), cognition, @entity146 , quality of life and caregiver burden (secondary) were obtained at baseline and at 6 and 12 weeks following randomization. For each outcome measure, intent-to-treat analyses using linear random effects models were performed. Feasibility and adverse events were also assessed. RESULTS: Adherence to the exercise program was good. On the primary outcomes (functional performance) @entity1 in the exercise group demonstrated a trend for improved performance on measures of hand function and lower extremity strength. On secondary outcome measures, trends toward worse @entity308 and lower quality of life ratings were noted. CONCLUSIONS: The physical exercise intervention developed for the study, delivered by caregivers to home-dwelling @entity1 with @entity195 , was feasible and was associated with a trend for improved functional performance in this group of frail @entity1 . Given the limited efficacy to date of pharmacotherapies for @entity195 , further study of exercise intervention, in a variety of care setting, is warranted.
