Normocalcemic @entity6685 elevation after successful parathyroidectomy: long-term analysis of XXXX variations over 10 years.

@entity1 @entity459 @entity6685 @entity460 @entity461
BACKGROUND: The long-term significance of normocalcemic @entity6685 elevation (NPE) after successful parathyroidectomy for sporadic @entity459 remains unclear. METHOD: Of 239 consecutive @entity1 who underwent targeted parathyroidectomy with intraoperative @entity6685 monitoring, 96 were followed for >=  10 years. NPE was defined as a normal serum @entity460 level and @entity6685 ( @entity461 ) above the normal reference range >=  6 months after successful parathyroidectomy. Recurrence was defined as elevated serum @entity460 and @entity461 levels >=  6 months after parathyroidectomy. Risk factors for NPE, patterns of postoperative @entity461 variation, and 10-year outcomes were analyzed. RESULTS: Of 96 @entity1 followed >=  10 years, 42 had postoperative NPE. Only male gender (P = .008) was a risk factor for NPE, and NPE did not predict recurrence. Three patterns of postoperative NPE were identified in @entity1 with >=  3 @entity461 measurements over this 10-year period. Group 1 (n = 11): 1 to 2 consecutive @entity461 elevations; none recurred, and most were explained by physiologic variation. Group 2 (n = 23): multiple @entity461 fluctuations; 3 recurred, and almost all had physiologic variations. Group 3 (n = 4): @entity461 always elevated; 2 recurred. CONCLUSION: Postoperative NPE may be a dynamic, reversible, and transient clinical entity that does not predict recurrence. Nevertheless, @entity1 with postoperative NPE should be monitored and an attempt made to correct any obvious potential causes of @entity461 elevation.
