Parameters of biological activity in XXXX .

@entity1 @entity650 @entity4725 @entity7 @entity5 @entity3012 @entity1735 @entity2843 @entity1254 @entity10580 @entity1014 @entity14 @entity1495 @entity688 @entity2071
BACKGROUND: The aim of this study was to measure several parameters in @entity1 with early-stage @entity14 ( @entity14 ) and to evaluate them for their utility in routine clinical practice. @entity1 AND METHODS: Pre-operative serum levels of the following parameters were measured in 174 @entity1 with @entity14 (clinical stage I-III): @entity10580 ( @entity10580 ), @entity1735 antigen CA 19-9, proliferative marker @entity1014 kinase (TK), tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS), @entity650 ( @entity650 ), @entity688 ( @entity688 ), @entity1495 ( @entity1495 ), @entity2843 ( @entity2843 ), @entity2071 ( @entity2071 ), @entity4725 ( @entity4725 ), @entity7 ( @entity7 ), C-peptide, insulin, @entity1254 and leptin. The control group consisted of 50 @entity1 who were undergoing a complete preventive medical examination and in these @entity1 at the time of blood collection there was no evidence of any @entity5 . RESULTS: Significant increase of the following parameters was found in @entity1 with @entity14 : @entity10580 , CA 19-9, TPA, @entity650 , @entity688 , @entity2843 , C-peptide, insulin and @entity1254 . Only two of these, @entity1254 , represent highly unfavorable prognostic factors. If elevated, they affect both progression-free interval and overall survival. CONCLUSION: Based on our results, we can conclude that none of the measured parameters fulfills the criteria for use for screening nor for primary diagnosis of @entity14 . Some of the parameters are important for prognosis estimate: Elevated CA 19-9 is related to an unfavorable prognosis, in terms of @entity5 recurrence and mortality rate. Angiogenetic factor @entity7 represents a prognostic factor important for @entity3012 . @entity10580 represents a parameter which is related to disease progression. Interleukins seem to be prospective @entity5 markers. @entity1254 may be used for estimation of advanced stage of @entity5 and for estimate of risk of @entity5 recurrence.
