@entity1068 extraction of Picrorhiza scrophulariiflora prevents @entity8 in experimental @entity6 via anti- XXXX action.

@entity1 @entity32 @entity8 @entity14554 @entity6 @entity2316 @entity657 @entity3839 @entity1110 @entity633 @entity1234 @entity1810 @entity35 @entity1068
There is evidence that inflammatory processes are involved in the development and/or progression of @entity2316 . However, effective treatment for @entity32 in the kidneys of @entity6 is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the @entity1068 @entity14554 ( @entity14554 ) may reduce @entity32 in @entity1 with @entity6 kidneys. @entity3839 -induced @entity6 @entity35 were randomly assigned to two groups treated with a gavage of either @entity14554 or vehicle. A group of non- @entity6 control @entity35 was treated concurrently. Compared with vehicle-treated @entity6 @entity35 , @entity14554 -treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of @entity657 ( @entity657 ) and @entity1810 . This was associated with attenuation of the structural and functional abnormalities of early @entity2316 , such as @entity8 , mesangial expansion, and @entity633 . Administration of @entity14554 significantly reduced @entity1110 oxidase-dependent superoxide generation and decreased expression of @entity1234 and advanced oxidation protein products in @entity6 kidney. These data suggest that @entity14554 might improve @entity2316 , probably through inhibition of redox-sensitive @entity32 .
