[ XXXX : diagnosis and risk stratification].

@entity1789 @entity944 @entity1372 @entity1163 @entity74 @entity299 @entity1167 @entity943
@entity1789 is a @entity74 , leading to a functional reduction in @entity1372 channel current. This anomaly occurs in the absence of other demonstrable @entity299 . The ECG diagnostic pattern is characterized by coved ST-segment elevation in V1-V3 leads. @entity1789 may be complicated by malignant @entity943 and @entity944 . Risk stratification in individuals with type 1 Brugada ECG pattern for primary prevention of @entity944 is an unsolved issue. Recognized risk factors for @entity944 are spontaneous type 1 ECG pattern, @entity1163 , or documented @entity1167 . Family history of @entity944 is a controversial risk factor. However, all these factors have a low positive predictive value. The prognostic significance of electrophysiological study (EPS) is debated. There is a consensus about the low predictive value of a positive EPS and a low specificity. However, while some authors deny at all its usefulness, others suggest that EPS is useful when considered together with other clinical risk factors. According to Brugada brothers our personal data suggest that (i) in subjects with type 1 Brugada ECG no single clinical risk factor nor EPS alone are able to identify subjects at the highest risk; (ii) a multiparametric approach (including @entity1163 , family history of @entity944 and positive EPS) helps to identify populations at the highest risk; (iii) subjects at the highest risk are those with a spontaneous type 1 ECG and at least two risk factors; (iv) the remaining are at low risk.
