XXXX as a risk factor for @entity301 in the @entity1605 .

@entity1 @entity1605 @entity301 @entity146 @entity458
BACKGROUND: @entity146 and @entity458 are increasingly recognized as risk factors for @entity301 ( @entity301 ). Elucidation of the mechanisms of these associations has implications for prevention. This study aims to confirm the association between @entity458 and @entity301 and examine if it could be explained by other factors such as health behaviours, social isolation and low control at work. METHODS: A prospective occupational cohort study of London-based civil service employees ( @entity1605 ) with baseline data collected from 1985-1988 with a 5-year follow-up. The @entity1 were male and female middle-aged civil servants working in 20 Government Departments; 73% of eligible employees attended baseline screening. @entity458 measured by the General Health Questionnaire (GHQ) at baseline was used to predict incidence of self-reported @entity301 and possible and probable electrocardiographic (ECG) abnormalities during follow-up. RESULTS: In @entity1 , baseline @entity458 was associated with an increased incidence of overall self-reported @entity301 (odds ratios [OR] = 1.83, 95% CI : 1.5-2.3) and ECG abnormalities (OR = 1.51, 95% CI : 1.1-2.1), after adjustment for age, employment grade and length of follow-up. In @entity1 , baseline @entity458 was also associated with an increased incidence of @entity301 (OR = 1.60, 95% CI : 1.2-2.1), but not with ECG abnormalities. Adjustment for health behaviours, marital status, social networks and work characteristics reduced the risks for incident @entity301 by 12% in @entity1 and by 10% in @entity1 ; for ECG abnormalities these adjustments increased the risk in @entity1 by 16% and had little effect in @entity1 . CONCLUSIONS: The experience of @entity458 confers increased risk of @entity301 in @entity1 that is not explained by health behaviours, social isolation or work characteristics. The increased risk of @entity301 associated with @entity458 is not consistently demonstrated in @entity1 .
