@entity12698 mitigates cigarette smoke induced oxidative stress in XXXX .

@entity32 @entity12698 @entity1996 @entity5 @entity19 @entity2041 @entity133 @entity2197 @entity224 @entity105 @entity1981
@entity1981 ( @entity1981 ) is a rich source of radicals, predisposing the cell to oxidative stress resulting in @entity32 . @entity32 is a recognized risk factor for @entity105 . @entity1996 ( @entity1996 ) is a mediator of inflammatory pathway and may, therefore, contribute to @entity105 . There are several reports that suggest the association between @entity1981 and @entity1996 associated risk to @entity5 . In the present study, we examined the role of @entity12698 (a selective @entity1996 inhibitor) in modulating the oxidative stress caused by @entity1981 inhalation in @entity19 . @entity1981 exposure for a period of 10 weeks caused oxidative stress in the pulmonary and hepatic tissues, as evident from the increase in lipid peroxidation levels (LPO) and decrease in @entity2041 ( @entity2197 ) levels. @entity12698 (125 mg/kg body weight for 8 weeks) administration to @entity1981 inhaling @entity19 reduced the oxidative stress by decreasing the LPO levels and enhancing the @entity2197 levels in comparison to the @entity1981 -exposed group. @entity1981 exposure repressed the enzymatic antioxidant defense system, as evident from the decrease in catalase (CAT) and @entity224 dismutase (SOD) activities. Co-adminstration of @entity12698 considerably reversed the changes in the enzymatic antioxidant defense system. Histopathological studies of lungs showed that @entity1981 exposure induced alveolar wall destruction and air space enlargement. In co-treated group, the @entity133 were thicker than normal with apparent infiltration of inflammatory cells. In @entity1981 -exposed group, hepatic tissue exhibited vacuolization and macrophage infiltration. Co-treatment with @entity12698 restored the normal histoarchitechture in hepatic tissues of @entity1981 inhaling @entity19 . Thus, the present study demonstrated that @entity12698 adminstration reduced the oxidative stress-mediated risk to @entity105 , due to its ability to boost the antioxidant defense system.
