Expression of bone morphogenetic proteins 4, 6 and 7 is downregulated in kidney allografts with XXXX and @entity194 .

@entity82 @entity1841 @entity13062 @entity11673 @entity12017 @entity194
PURPOSE: Bone morphogenetic proteins (BMPs) are pleiotropic growth factors. This paper investigates the connection between the expression pattern of BMPs in kidney allograft tissue versus the cause of allograft dysfunction. METHODS: The expression pattern of @entity1841 , @entity13062 , @entity11673 and @entity12017 in 50 kidney allografts obtained by transplant nephrectomy is investigated. Immunohistochemical staining is semiquantitatively evaluated for intensity to identify the expression pattern of BMPs in normal and allograft kidney tissues. RESULTS: The expression of @entity13062 is unique between different tubular cell types in grafts without signs of @entity82 . This effect is not found in specimens with high grades of @entity82 and @entity194 (IFTA). In samples with IFTA grades II and III, the @entity12017 expression is reduced in a significant fraction of specimens relative to those without signs of IFTA. The expression pattern of @entity11673 indicates that its activation may be triggered by the act of transplantation and subsequent reperfusion injury. The expression of @entity1841 is strong in all types of tubular epithelial cells and does not differ between the compared allografts and control kidney specimens. CONCLUSION: The intensity and expression pattern of @entity13062 , @entity11673 and @entity12017 in transplanted kidney tissue are found to be dependent upon the length of the transplanted period, the clinical indication for transplant nephrectomy and signs of IFTA in kidney tissue.
