Perfluorinated organic liquid as an intraocular @entity26 reservoir for the XXXX retina.

@entity2479 @entity1713 @entity63 @entity26 @entity95 @entity37553
PURPOSE: Liquid perfluorocarbons are used as temporary vitreous substitutes in the surgical management of complicated @entity1713 . The purpose of this study was to determine if physiologic benefits could also be derived from the high @entity26 solubility of perfluorochemicals relative to vitreous, especially during @entity2479 . METHODS: The normal vitreous humor of the @entity95 eye was replaced with either @entity37553 ( @entity37553 ) or balanced salt solution (BSS). @entity2479 was then induced by increasing the intraocular pressure above the peak systolic blood pressure for intervals of 10, 30, or 90 minutes. RESULTS: Over a 10- or 30-minute period of @entity63 , during which electroretinographic (ERG) responses were recorded, @entity37553 -filled eyes and BSS-filled eyes showed decreases in the a- and b-wave amplitudes. However, wave amplitudes were significantly greater in @entity37553 -filled eyes at most times examined (P < .05). ERG responses were maintained throughout a 30-minute @entity63 interval in oxygenated @entity37553 -filled eyes, but not in oxygenated BSS- or deoxygenated @entity37553 -filled eyes. When examined 1 day after a 90-minute interval of @entity63 , oxygenated @entity37553 -filled eyes maintained 45% and 57% of the preischemic ERG a- and b-wave amplitudes, respectively, compared to a 5% and 3% retention of wave amplitudes in oxygenated BSS-filled eyes. On light microscopic examination of these eyes, @entity37553 -exposed retinas showed less @entity63 damage than BSS-exposed retinas. CONCLUSIONS: When used as a vitreous substitute, @entity37553 exerts a neuroprotective effect on the @entity63 retina that appears to relate to an increased retinal @entity26 supply compared to BSS.
