Prevalence and molecular characterizations of enterovirus D68 among XXXX with acute @entity1729 in China between 2012 and 2014.

@entity1 @entity565 @entity1729
UNASSIGNED: EV-D68 is associated with @entity1729 ( @entity1729 ). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized @entity1 with @entity1729 . Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the @entity1 with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 @entity1 had a discharge diagnosis of @entity565 . Of these, 11 @entity1 were diagnosed with acute @entity565 exacerbation. EV-D68 was the predominant pathogen that evoked @entity565 exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced @entity565 exacerbation may be a clinical feature of EV-D68 infection.
