Effects of intra-abdominal pressure on adrenal gland function and morphology in XXXX .

@entity5733 @entity1425 @entity2819 @entity8479 @entity35 @entity1063
@entity8479 and @entity8479 (IAH/ACS) are life-threatening conditions and caused by several clinical status. Although there is insufficient data regarding its effects on adrenal glands. This study aimed to identify whether elevated intra-abdominal pressure (IAP) caused any alteration on the morphology and function of adrenal glands in a @entity35 model. Twenty four Sprague-Dawley male @entity35 were included in the study. Animals were allocated into 4 groups. IAP was elevated to 15 mmHg for one hour and four hours in group 2 and 4. Group 1 and 3 were sham groups. Blood samples were taken for the assessment of plasma @entity1425 , @entity1063 , and @entity2819 levels and adrenalectomies were performed to evaluate apoptosis. Blood @entity1425 , @entity1063 and @entity2819 levels were significantly higher in the study groups compared with the sham groups. However, there were no significant changes in apoptotic index scores in the study groups as compared to sham groups. These results support that increased IAH leads to discharge of @entity5733 and @entity2819 from the adrenal glands. Failure to demonstrate similar changes in apoptotic index score may be concluded as apoptosis is not a leading pathway for impairment of adrenal glands during IAH period.
