Red cell and plasma antioxidant components and atherosclerosis in XXXX : a time-course study.

@entity1674 @entity412 @entity4793 @entity5872 @entity165
Our study aims to examine changes in red cell and plasma antioxidant components in relation to age and aortic lesion development in SUS @entity5872 during a 12-week period of dietary @entity165 supplementation. One hundred adult SUS males were divided into 5 treatment groups and were fed either a control or a @entity165 -supplemented (0.5% w/w) diet. Birds were sacrificed after 0, 4, 8 and 12 weeks on the diets and examined for plaque development and antioxidant components status. "Aging" was associated with increases in the activity of red cell SOD and GPx. Significant correlations among red cell GRd, GPx and SOD activities were found in old but not in younger adult birds. Plasma @entity412 levels increased, while plasma @entity4793 level decreased with aging. With birds on the @entity165 diet, plaque score increased with time and regressed significantly but negatively on plasma @entity165 level at the initial stage of atherogenesis. Aortic @entity1674 showed a drastic increase in the early stage of atherogenesis but returned to the pretreatment level during the late stage. Conversely, aortic @entity165 showed small increases at the early stages but large increases during the late stage. Red cell antioxidant components showed increases at the early and late stages with a leveling off at the mid stage. Plasma GRd activity decreased while plasma @entity4793 level increased (after adjusting for the effect of effect of aging) with @entity165 feeding. We conclude that the increase in plasma @entity412 levels and associations among red blood cell GRd, GPx and SOD activities in "old" birds fed the control diet resembled the situation in the early stages of atherogenesis in the @entity165 -fed birds. This would be consistent with the known permissive effect of aging on the course of atherogenesis. Triglycerides may play a crucial role in atherogenesis during the early phase of lesion development. Early and late phases of lesion development are biochemically distinct, indicating that the process of atherogenesis is a highly dynamic one. The patterns of antioxidant alterations associated with lesion development showed a complex time-dependence.
