@entity66 following administration of levothyroxine in subjects suffering from XXXX .

@entity1375 @entity8415 @entity274 @entity66 @entity17978 @entity2016 @entity148 @entity2146 @entity10
AIM: @entity66 ( @entity66 ) in subjects with @entity1375 under therapy with @entity2016 might be the cause of the side effects commonly found with this treatment. METHODS: Twenty-four subjects of both sexes (11 M and 15 F), aged between 41 and 61 years, with @entity1375 were assessed. All the subjects were followed for 30 days during the administration of a fixed dose of 75  g of @entity2016 . Levels of T4, T3, TSH, @entity8415 (as measure of @entity66 ), hs-CRP were determined in plasma before and after the treatment. Side effects ( @entity148 / @entity2146 , sweating, palpitations and @entity10 ) and number of days of discomfort were measured for 15 days before and for two subsequent 15-day periods. RESULTS: Administration of @entity2016 satisfactorily balanced the @entity1375 . A high level of @entity8415 , 370    27.7 U. @entity17978 . (Carratelli Units: 1 U. @entity17978 . = 0.08 mg of @entity274 /L), was observed before treatment, and @entity2016 administration further increased the level up to 435    39.5 U. @entity17978 (p<0.05). The treatment produces a significant increase in hs-CRP, from 3.2    2.32 to 4.0    1.27 mg/L (P<0.05). Side effects, almost absent at the baseline 15-day control, occurred with high frequencies during the treatment: between 9.6    1.14 days/15 days for sweating and 14.1    0.93 days/15 days for palpitations. Some side effects were found to be linearly correlated with @entity8415 (r=0.641, P<0.01 and r=0.658, P<0.01 respectively) or with hs-CRP, as in the case of @entity148 / @entity2146 (r=0.629, P<0.01). Following @entity2016 administration the days of discomfort turned out to be particularly prominent during the two subsequent 15-day controls (3.8    0.75 and 4.8    0.78 days respectively). CONCLUSION: @entity1375 and therapy with @entity2016 at a dose of 75  g/day cause @entity66 . Side effects following @entity2016 therapy depend on @entity66 and cause daily discomfort and loss of working activity in about 1/3 of the days considered.
