A @entity235 model of @entity130 induced by XXXX . Lung mechanics and morphologic features.

@entity20298 @entity32 @entity1568 @entity82 @entity235 @entity26 @entity32428 @entity1224 @entity130
We created a model of @entity1224 that avoids long-term toxic exposure. @entity130 was induced in 7 @entity235 by exposure to nebulized 1% @entity32428 ( @entity20298 ) on alternate days for 4 wk. Lung mechanics were measured prior to exposure and after 2 and 4 wk. Both TLC and VC decreased and the FRC/TLC ratio increased. Expiratory flows decreased while breathing air and an 80% helium-20% @entity26 mixture; the volume of isoflow increased. Pulmonary resistance increased and dynamic compliance decreased. On single-breath @entity1568 washout, there were increases in the slope of phase III and in closing capacity. Histologically, there was widespread chronic @entity32 , slight epithelial changes, slight peribronchiolar @entity82 , and an increase in smooth muscle. Pathologic scores were significantly higher in the @entity20298 -exposed group than in the control group. Scores for peripheral and central airway pathology were correlated with results of tests of @entity1224 .
