Thyroid H  rthle cell XXXX : research of potential markers of @entity5 .

@entity1 @entity1637 @entity1374 @entity1313 @entity5 @entity189 @entity2513 @entity652 @entity59843 @entity4452
INTRODUCTION: @entity1637 ( @entity1637 ) are rare @entity1374 . To date, capsular and/or vascular invasion are the only findings predicting @entity5 . Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis ( @entity59843 and @entity4452 ), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), @entity59843 and @entity4452 expression as diagnostic markers of @entity5 in HCT. MATERIALS AND METHODS: Eighty @entity1 with HCT (32 @entity189 , 48 @entity652 ) whom underwent surgery in our center were included. Samples of both @entity1313 and adjacent normal thyroid tissue were analyzed by means of tissue micro-arrays. Correlations between expressions of Ki67, @entity59843 and @entity4452 and final histology were analyzed. RESULTS: Mean size of the lesion was higher in @entity189 than in @entity652 (p  =  0.01). @entity59843 and @entity4452 were significantly underexpressed in Hurthle cells @entity5 compared to normal tissue (p  =  0.0004 and p  =  0.0001, respectively). Ki67 and @entity59843 were, respectively, higher and down-expressed in @entity189 compared to @entity652 (p  =  0.0004 and p  =  0.005, respectively). On multivariate analysis, size correlates with @entity189 diagnosis. Neither @entity59843 nor Ki67 index was related to size. The expression of @entity4452 was reduced in both @entity2513 but differences were not statistically significant (p  =  0.13). CONCLUSIONS: Our study suggest that Ki67 and @entity59843 correlate with @entity5 in HCT. The expression of @entity4452 is down-regulated in HCT, but it is not diagnostic of @entity189 . Ki67 and @entity59843 may potentially help as cytological markers of @entity5 in HCT.
