Trends in use of adjuvant multi-agent chemotherapy and XXXX for @entity0 in the United States: 1975-1999.

@entity0 @entity1 @entity5 @entity440
BACKGROUND: Understanding trends in the dissemination of findings from clinical research can help in estimating their population-level benefits. We evaluated trends in the use of adjuvant multi-agent chemotherapy, @entity440 , and the combination of both treatments for @entity0 in the United States from 1975 through 1999. METHODS: Data on treatment of 217 508 @entity1 diagnosed from 1975 through 1999 with stages I, II, and IIIA @entity0 were obtained from eight registries of the Surveillance, Epidemiology, and End Results (SEER) Program. Models of dissemination were developed from these data after adjustment based on information from a series of population-based Patterns of Care (POC) studies that randomly selected case @entity1 from the SEER registries. The POC studies included 7116 @entity1 diagnosed from 1987 through 1991 and in 1995 who were eliminated from the SEER data used in this analysis. RESULTS: The modeled disseminations were generally compatible with the POC-observed proportions of each treatment. The use of multi-agent chemotherapy was higher among premenopausal @entity1 , and the use of @entity440 was higher among postmenopausal @entity1 . The use of multi-agent chemotherapy for postmenopausal @entity1 diagnosed with @entity5 reached a peak in 1983 and then decreased through 1986, indicating its substitution with @entity440 . After 1986, the combined use of multi-agent chemotherapy and @entity440 increased for almost all stages and ages. After the early 1990s, @entity440 use in postmenopausal @entity1 with stage II+ or @entity0 declined. CONCLUSIONS: The observed dissemination patterns suggest that the results of clinical trials are disseminated fairly rapidly to community-based physicians and their @entity1 .
