Gastric B-cell mucosa-associated XXXX . Clinicopathological study and evaluation of the prognostic factors in 143 @entity1 .

@entity1 @entity353 @entity6595 @entity5 @entity1074 @entity1897 @entity382 @entity1893
BACKGROUND: @entity6595 can be histologically classified into two groups, low-grade ( @entity1893 ) and high-grade ( @entity1893 ); however, their natural history is poorly understood. We have studied a large retrospective series aiming to confirm whether the histological groups confer different clinical features and behavior and to analyze the prognostic factors in these @entity1 . @entity1 AND METHODS: A series of 143 gastric B-cell @entity1074 is reported. Eighty-four were @entity1893 ( @entity1893 ) and 59 were @entity1893 ( @entity1893 ). Median follow-up was 36 months. The clinical and analytical parameters of the 84 @entity1893 @entity1 were compared with those of the 59 @entity1893 @entity1 . In the @entity1 who had been operated on, the pathological features (macroscopical patterns, @entity5 size, involvement of resection margins, degree of parietal invasion and involvement of abdominal lymph nodes and adjacent viscera) of the @entity1893 @entity1 were compared with those of the @entity1893 @entity1 . The sites of relapses were studied. In the 132 treated and followed-up @entity1 the influence of the treatment and that of clinical, analytical and pathological features on survival were investigated with the Kaplan and Meier and log-rank tests. To identify the factors with independent influence on survival, a Cox model was fitted for the whole series and separately for 53 @entity1893 @entity1 . RESULTS: @entity1893 group differed from the @entity1893 group by a significantly higher frequency of @entity353 at presentation, palpable abdominal mass, @entity382 , @entity1897 , elevated serum LDH, higher incidence of stage III-IV and @entity5 /mass patterns in the endoscopy and in the gastrectomy specimen. The @entity5 was significantly larger in the @entity1893 group than in the @entity1893 and the deeper invasion of the gastric wall, the higher frequency of infiltration of the abdominal lymph nodes and the visceral extension were also significant in the @entity1893 group. Complete remission (CR) was achieved in 91% of the @entity1 of the @entity1893 group, but was significantly lower, 70%, in the @entity1893 group. Relapses occurred in the stomach and also in non-MALT sites. In 132 treated and followed-up patients, elevated serum LDH, absence of CR, @entity1893 group and stage III-IV were associated with a worse survival. In the Cox multivariate model, stage was the only variable influencing survival, although stage was related to the histological grade. In the @entity1893 group, stage was also an independent significant risk factor, whereas treatment with surgery, chemotherapy or both was not. In the 103 @entity1 treated with surgery, a worse survival was associated with the involvement of the resection borders, depth of the infiltration of the gastric wall, dissemination to distant abdominal nodes and adjacent organs, but not with the addition of chemotherapy. CONCLUSIONS: Histological classification into @entity1893 and @entity1893 separates distinctive groups of @entity6595 that show striking clinical and prognostic differences. Besides histological grade, stage is the most important prognostic feature.
