The role of epigenetics in XXXX .

@entity8 @entity5 @entity5464 @entity1358 @entity150 @entity703
INTRODUCTION: @entity1358 ( @entity1358 ) are collectively the third most common @entity5464 , surpassed only by prostate and @entity150 . Cure rates for @entity1358 are related to @entity5 grade and stage; therefore, diagnostic methods for early detection and new therapeutic modalities are of paramount importance. Epigenetics can be defined as inherited modifications in gene expression that are not encoded in the DNA sequence itself. Epigenetics may play an important role in the pursuit of early diagnosis, accurate prognostication and identification of new therapeutic targets. MATERIAL AND METHODS: We used PubMed to conduct a comprehensive search of the English medical literature using search terms including epigenetics, DNA methylation, histone modification, microRNA regulation (miRNA) and @entity1358 . In this review, we discuss the potential application of epigenetics in the diagnosis, prognosis and treatment of @entity703 . RESULTS: During the last decade, many different types of epigenetic alterations of DNA have been found to be associated with @entity703 . This has led to the research of the diagnostic and prognostic implications of these changes in @entity8 as well as to the development of novel drugs to target these changes, with the aim of achieving a survival benefit. CONCLUSIONS: Epigenetics has become a promising field in @entity5 research. The potential to achieve early detection and accurate prognostication in @entity703 might be feasible through the application of epigenetics. The possibility to reverse these epigenetic changes with new therapeutic agents motivates researchers to continue pursuing better treatment options for @entity703 and other @entity5 .
