Combined intravesical XXXX and mitomycin chemotherapy: a preliminary in vivo study.

@entity1 @entity32 @entity742 @entity548 @entity1494 @entity4 @entity1138 @entity150 @entity221
Previous clinical studies of the combination of local intravesical @entity221 with cytostatic drugs for the treatment of Superficial Transitional Cell @entity150 (STCCB) showed encouraging results both in reducing recurrence rate to 20-30% within 2 years and in ablative success rate of 79%. Our objectives were to evaluate bladder tissue and adjacent organs during and following @entity221 treatment. An intravesical catheter equipped with a radio-frequency antenna (Synergo SB-TS 101.1 System) was used for @entity221 and intravesical chemotherapy ( @entity1138 ) was instilled in vivo for 60 min in two anaesthetized @entity742 . Thirteen to fifteen thermocouples were sewn surgically on the internal and external surfaces of the bladder wall and on adjacent organs to monitor the temperature during the treatment. We expected the intravesical temperature to be under 46 degrees C and the external layers below 45 degrees C. The bladder was filled with 50 mL of chemotherapeutic solution (400 micro g/mL of @entity1138 in distilled water). The @entity742 were sacrificed at the end of the treatment. Three other @entity742 , which underwent thoracic surgery, served as control group. Histological changes in both groups showed foci of @entity4 and @entity548 with @entity32 in the lamina propria and serosa. Foci of desquamation of the epithelium were noticed in the treated @entity742 . Histological analysis of the treated group showed no significant differences from the control group. The control group showed similar changes, some less pronounced. The combined treatment of @entity221 with @entity1138 did not cause major @entity1494 or adjacent organs. All changes were superficial and reversible, and the control group showed similar changes, some less pronounced. Although this is an experimental model based on one single session treatment, rather than repeated treatments, it suggests that the approach may be useful in future studies both in models and @entity1 .
