Role of NK cells in adoptive immunotherapy of metastatic @entity14 in a syngeneic XXXX model.

@entity1008 @entity5 @entity5041 @entity14 @entity35
This article reviews our immunotherapy research with natural killer (NK) cells in a syngeneic @entity35 @entity14 and lung metastasis model. Using adoptive transfer of @entity5041 -activated NK cells, NK cells were shown to selectively infiltrate the @entity5 . More NK cells were found in @entity5 when the NK cells were directly injected into @entity5 -draining blood vessels than when the cells were injected in systemic blood vessels. Under optimal conditions, a limited, though significant, effect of adoptively transferred NK cells on @entity5 growth was shown. We observed that both endogenous and adoptively transferred NK cells were predominantly present in the stroma surrounding the @entity5 cell nodules. It is possible that they did not penetrate the nodules containing the @entity5 cells because of the presence of a basal membrane-like structure around these nodules. Adoptively transferred NK cells may initiate elimination of @entity5 cells by activating other effector cells, whereas some may eliminate @entity5 cells by direct cell-cell contact. A diverse array of molecules was shown to be involved in this process. @entity1008 on NK cells was found to be important in initiating the lysis-inhibitory signal upon binding of 'self' major histocompatibility complex (MHC) class I on potential target cells. Our results indicate that NK-cell @entity5 therapy is still promising and needs improvement.
