[The significance of XXXX for contractility of smooth muscles and ultrastructure of their microfilaments in case of hypodynamic stress].

@entity219 @entity35455 @entity95 @entity3774 @entity934
The aim of the study was to investigate the significance of @entity219 (added to food of the @entity95 ) for contractility of smooth muscles (effected by @entity934 ) and ultrastructure of their microfilaments in case of hypodynamic stress. Hypodynamic stress of 48-day duration was provoked for Chinchilla @entity95 (n=20) by placing them in metal hutches. Every day (48 days) 10 @entity95 , which had intervention received doses of @entity219 0.3 mg/kg body wt (in form of @entity35455 ). The @entity95 (n=10) of the control group, which had no intervention were kept in vivarium conditions. The relaxation of smooth muscles from thoracic aorta as mediated by @entity934 at a concentration from 10(-8) mol/l to 10(-4) mol/l was detected by means of a 6MXIC mechanotron in isometric regime. Response was expressed as the percentage of relaxation to @entity3774 (10(-5) mol/l)-induced precontraction. The ultrastructure of the microfilaments of smooth muscles was evaluated by electron microscopy "Philips-300". In @entity95 that received no @entity219 the relaxation of smooth muscles under the influence of @entity934 was significantly lower than in @entity95 that received @entity219 and lower in control @entity95 . Also in @entity95 without @entity219 supplement the investigation of ultrastructure of microfilaments revealed their damage (such change as irregular formation, drop out in flakes, microfilaments becoming shorter and thicker). In @entity95 receiving @entity219 ultrastructure of microfilaments did not change.
