Quantitative measurement of blood-brain barrier permeability in XXXX using dynamic contrast-enhanced MRI with fast T1 mapping.

@entity1 @entity16 @entity7241
Breakdown of the blood-brain barrier (BBB), occurring in many @entity16 , has been difficult to measure noninvasively in @entity1 . Dynamic contrast-enhanced magnetic resonance imaging measures BBB permeability. However, important technical challenges remain and normative data from healthy @entity1 is lacking. We report the implementation of a method for measuring BBB permeability, originally developed in animals, to estimate BBB permeability in both healthy subjects and @entity1 with white matter pathology. Fast T(1) mapping was used to measure the leakage of contrast agent @entity7241 ( @entity7241 ) from plasma into brain. A quarter of the standard @entity7241 dose for dynamic contrast-enhanced magnetic resonance imaging was found to give both sufficient contrast-to-noise and high T(1) sensitivity. The Patlak graphical approach was used to calculate the permeability from changes in 1/T(1). Permeability constants were compared with cerebrospinal fluid albumin index. The upper limit of the 95% confidence interval for white matter BBB permeability for normal subjects was 3 * 10(-4) L/g min. MRI measurements were not [corrected] correlated strongly with levels of cerebrospinal fluid albumin in those subjects undergoing lumbar puncture. Dynamic contrast-enhanced magnetic resonance imaging with low dose @entity7241 and fast T(1) imaging is a sensitive method to measure subtle differences in BBB permeability in @entity1 and may have advantages over techniques based purely on the measurement of pixel contrast changes.
