Pregnancy-related relapse risk factors in women with anti- XXXX antibody positivity and @entity1652 spectrum disorder.

@entity1 @entity66 @entity1652 @entity2142 @entity3951 @entity15
BACKGROUND: Few reports describe the influence pregnancy has on the annualized relapse rate (ARR) in @entity1652 spectrum disorder (NMOSD). OBJECTIVE: To examine pregnancy-related attacks (attacks during pregnancy or within 1 year postpartum) and identify the risk factors for an attack in Japanese NMOSD @entity1 . METHODS: We retrospectively reviewed 139 Japanese @entity1 whom had @entity3951 ( @entity3951 ) antibody-positive NMOSD. Among the 114 @entity1 with information, 47 @entity1 had 56 pregnancies. We compared the ARR before, during and after pregnancy. RESULTS: Of the 47 NMOSD @entity1 with pregnancy, 22 @entity1 (46.8%) had a @entity66 (either an onset event or a relapse). The ARR was significantly higher in the first 3 months postpartum (1.80    2.04), than before the pregnancy (0.57    1.16; p = 0.0043) and did not significantly decrease during pregnancy. The ARR before hospitalization and treatment was analyzable in 55 @entity1 without pregnancy and was 1.09    1.17. Among the 11 @entity1 with onset before pregnancy, nine @entity1 had a @entity2142 with a relapse in the previous year, and their immunosuppression was discontinued or made to be at low doses; while the two @entity1 on higher-dose therapies were relapse-free. CONCLUSION: In the present study, @entity2142 was common in NMOSD, and unlike in @entity15 , the ARR was not reduced during pregnancy. Discontinued or insufficient immunosuppression appeared to increase the risk of @entity2142 .
