Defective fibrinolysis: a risk factor in early femoropopliteal graft XXXX .

@entity432 @entity1 @entity715
Resting plasma fibrinolytic activity and fibrinolytic activity after stimulation by 10 min of @entity432 (fibrinolytic potential) were estimated in 51 @entity1 before femoropopliteal reconstructive surgery. Twelve @entity1 suffered a graft @entity715 in the first month. Resting plasma fibrinolytic activity was similar in @entity1 with thrombosed grafts and those with functioning grafts. However reduced fibrinolytic potential was found to be a risk factor for graft @entity715 in the month after surgery (P = 0.01). Other risk factors were increasing age (P = 0.007) and the indication for surgery (P = 0.03). Thirty-four @entity1 whose grafts were functioning after 1 month were followed up for a mean of 9 months. A further eight grafts thrombosed. Neither fibrinolytic activity nor fibrinolytic potential were found to be risk factors for late graft @entity715 . Fibrinolytic potential has been shown to be an independent risk factor for early graft @entity715 . Perioperative fibrinolytic stimulation might be a method of improving femoropopliteal graft patency.
