Genetic variations in @entity18068 in XXXX .

@entity1 @entity31978 @entity31979 @entity2023 @entity72355 @entity72357 @entity56 @entity72356 @entity379 @entity3646 @entity4334 @entity18068
UNASSIGNED: Interleukin (IL)-12B is a key regulator in the protection against @entity56 induced by various allergens in @entity1 with @entity2023 ( @entity2023 ). This study was performed to investigate the associations between single @entity4334 polymorphisms in the @entity18068 gene and @entity2023 in a Chinese Han population. A total of 543 @entity1 with @entity2023 and 600 healthy controls were genotyped for @entity18068 / @entity31979 , @entity72355 , @entity31978 , @entity72356 , and @entity72357 using polymerase chain reaction (PCR) restriction fragment length polymorphism and PCR direct sequencing. The expression of @entity18068 mRNA in peripheral blood mononuclear cells (PBMCs) obtained from normal controls was detected by quantitative real-time PCR. Levels of @entity379 and @entity3646 in culture supernatants were measured by enzyme-linked immunosorbent assay. The frequencies of the @entity31978 genotype with the CC and C alleles were higher in @entity1 with @entity2023 (p c  =  8.55  *  10(-4); p c  =  4.20  *  10(-4), respectively) than in normal controls. After peptidoglycan stimulation in PBMCs, IL-12 mRNA expression was reduced in healthy carriers of the CC genotype of @entity31978 . Additionally, decreased production of @entity379 was observed in @entity1 having the CC genotype as compared with that in @entity1 having the AC and AA genotypes. In contrast, @entity3646 expression was higher in @entity1 with the CC genotype than in @entity1 with the other two genotypes. The @entity18068 gene was involved in mediating susceptibility to @entity2023 .
