Compression inhibits aggregation of XXXX platelets under high hydraulic pressure.

@entity1 @entity2002 @entity1423 @entity535
It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of @entity1 platelets. The experimental design was based on the premise that oppositely charged @entity535 residues of @entity2002 are juxtaposed in the specific adhesive site(s). This can be explained by the principle of Le Chateller. Under compression, electrically charged groups gain layers of water molecules which are radially oriented and pulled in closer to the center of the charge, thus making the layer more compact. This increases the thickness of the shield, thus inactivating or disaggregating the platelets. Conversely, decompression drives the water away from the compact shield; water molecules are randomized into the bulk phase; the shield becomes thinner, thus permitting spontaneous aggregation of platelets. It is well known that increasing the concentration of neutral salt can inhibit @entity1423 . This is due to the increase of ionic strength which attenuates the electric charge and thickens the shield. Molecules having a large electric dipole moment can inhibit @entity1423 by a similar mechanism. It is generally accepted that @entity2002 is involved in @entity1423 . However, it is not known whether or not @entity2002 is essential for @entity1423 inducible by decompression. Here we present data indicating that @entity2002 is essential in decompression-inducible @entity1423 . We also present experimental data which show that high hydraulic pressure inhibits @entity1423 , consistent with our premise that electrically charged groups are involved in the initial phase of @entity1423 .
