Expression of the beta 6 integrin subunit in development, XXXX and tissue repair suggests a role in epithelial remodeling.

@entity1 @entity32 @entity5 @entity957 @entity189 @entity651
The alpha v beta 6 integrin was identified in cultured epithelial cells and functions as a fibronectin receptor. We have now used monoclonal antibodies to determine in vivo expression patterns of the beta 6 subunit in normal and pathological @entity1 or primate tissues, and during experimental wound healing or induced @entity651 . The results indicate that beta 6 expression is restricted to epithelia and is up-regulated in parallel with morphogenetic events, tumorigenesis, and epithelial repair. During development of the kidney, lung, and skin, we found that beta 6 is expressed by specific types of epithelial cells, whereas it is mostly undetectable in normal adult kidney, lung and skin. In contrast, we detected high-level expression in several types of @entity189 . For example, beta 6 is almost invariably neo-expressed in @entity957 derived from the oral mucosa, often focally localized at the infiltrating edges of @entity5 islands. Expression of beta 6 is also upregulated in migrating keratinocytes at the wound edge during experimental epidermal wound healing. Similarly, beta 6 expression is induced in type II alveolar epithelial cells during @entity651 caused by injection of live bacteria. We also observed beta 6 expression in adult lungs and kidneys at focal sites of subclinical @entity32 , as well as in a variety of clinical specimens from @entity1 with chronic or acute @entity32 of the lungs or kidneys. From these findings and earlier results, we hypothesize that alpha v beta 6 affects cell spreading, migration and growth during reorganization of epithelia in development, tissue repair, and @entity5 .
