[Morphologic features suggestive of submucosal invasive XXXX in colorectal mucosal biopsy specimens].

@entity82 @entity2735 @entity5 @entity189 @entity4494 @entity420
OBJECTIVE: To observe and summarize the morphologic features that may suggest submucosal invasive @entity420 in colorectal mucosa biopsy specimens. METHODS: The study cohort included 432 colorectal biopsy specimens were obtained from 2006 to 2012. All the cases had radical surgery. Basing on the pathologic diagnoses, the cases were divided into 366 invasive @entity420 (IAC) and 66 @entity2735 ( @entity2735 ). These two groups were compared. RESULTS: In the IAC group, the percentage of @entity5 forming cribriform structures, acute angle-shaped glands, diffuse @entity189 cell proliferation was 61.2% (224/366) , 33.8% (124/366) and 7.4% (27/366) , respectively. In the @entity2735 group, cribriform gland structures appeared in 6.0% (4/66) of the cases, while no acute angle-shaped gland or diffuse @entity189 cell proliferation was detected. The difference of these three characteristics in the two group was statistically significant (all P < 0.01). Glandular branching was detected in 89.9% (329/366) of IAC cases and 66.7% (44/66) of @entity2735 cases; this difference was not significant. There was no difference in cellular atypia between the two groups. Interstitial @entity82 was detected more frequently in the IAC group (85.5%, 313/366 in IAC versus 0 in @entity2735 , P < 0.01). In biopsy specimens of IAC, a few cases showed @entity5 in close contact with large lymphatics, adipose tissue, and @entity4494 . CONCLUSIONS: In colorectal biopsy specimen, the five features that suggest submucosal invasion of the @entity5 including the formation of cribriform structure, angular gland, diffuse @entity189 cells, interstitial @entity82 and @entity5 in close contact with the thick-walled vessels.
