XXXX of childhood in Denmark, 1943-1989: incidence and evaluation of histology using immunohistochemical techniques.

@entity5 @entity1 @entity44
In the Danish Cancer Registry, 72 @entity5 in @entity1 younger than 15 years of age were recorded during the period 1943-1989 and material from 34 of these was retrieved from Danish departments of pathology. The histological types were evaluated and the role of immunohistochemical staining was analysed. The survival of the @entity1 was correlated with the histological diagnoses, and changes in the incidence of @entity5 in childhood were analysed. Twenty-nine of the 34 @entity1 had germ cell @entity5 , which fell into two groups (infantile and pubertal) with distinct differences. The @entity5 of infancy usually presented before the age of 3 years and were either pure yolk sac @entity5 or @entity44 . The @entity5 of puberty showed no morphological or immunohistochemical differences from adult germ cell @entity5 . In the infantile group, immunohistochemical staining confirmed the morphological evaluation but was not necessary for diagnosis. @entity1 in the infantile group seemed to have a better prognosis than adult @entity1 , only one @entity1 dying from his disease, whereas the pubertal @entity1 seemed to have a prognosis similar to that of adult @entity1 . The incidence of @entity5 in Denmark appears to have increased at almost the same rate as that observed in adult @entity1 , but due to the small numbers in infancy, this cannot be statistically substantiated. We conclude that the testicular germ cell @entity5 of infancy and puberty may arise from different precursor cells, but both groups seem to arise prenatally.
