Stereotactic radiosurgery for recurrent XXXX .

@entity1 @entity424 @entity5 @entity9128
BACKGROUND: @entity1 with recurrent @entity9128 were evaluated to assess local control, overall survival, and complications from stereotactic radiosurgery (SRS). METHODS: Twelve @entity1 (with a total of 17 @entity5 ) with recurrent @entity424 underwent SRS. Local failure was defined as @entity5 progression within the prescription isodose volume, and marginal failure was defined as @entity5 progression adjacent to the SRS prescription isodose volume. @entity5 progression away from the prescription volume was considered distant failure. Eleven of the 12 @entity1 had undergone previous resection and external beam radiation therapy (46-56 Grays [Gy]; median, 54 Gy) before radiosurgery, and 1 @entity1 had failure after complete resection alone. Age at SRS ranged from 5-56 years (median, 29 years). Three @entity1 were female. The marginal @entity5 dose was 12-24 Gy (median, 18 Gy). One to 14 isocenters (median, 4 isocenters) were utilized to irradiate volumes of 0.3-15.5 cm(3) (median, 3.2 cm(3)). RESULTS: The duration of follow-up ranged from 2.5-60 months (median, 22.5 months). The median overall survival after SRS was 3.4 years (range, 1.4-5 years). In-field local control was achieved in 14 of the 17 @entity5 sites and estimated 3-year local control was 68%. There were two in-field failures and one marginal failure. Distant failure occurred in two @entity1 . Two @entity1 developed treatment-related complications after SRS. CONCLUSIONS: SRS provides good @entity5 control for @entity1 with recurrent @entity9128 and may have a favorable impact on survival. SRS should be evaluated more extensively in the initial treatment of @entity1 with @entity424 to minimize local failure after surgical management.
