Incidence, predictors and prognostic implications of XXXX complicating primary percutaneous coronary intervention.

@entity1 @entity1187 @entity712 @entity417 @entity548 @entity6 @entity101 @entity1503 @entity299 @entity583 @entity204
BACKGROUND/AIM: Data about @entity548 complicating primary percutaneous coronary intervention (PCI) are more frequently obtained from randomized clinical trials on @entity1 with @entity1187 ( @entity1187 ), but less frequently from surveys or registries on @entity1 with @entity583 ( @entity583 ). The aim of this study was to investigate the incidence, predictors and prognostic impact of in-hospital major @entity548 in the population of unselected real-world @entity1 with @entity583 undergoing primary PCI. METHODS: All consecutive @entity1 presenting with @entity583 who underwent primary PCI at a single large tertiary healthcare center between January 2005 and July 2009, were studied. @entity548 was defined according to the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) study criteria. We examined the association between in-hospital major @entity548 and @entity204 or major adverse @entity299 (MACE) in @entity1 treated with PCI. The primary outcomes were in-hospital and 6-month mortality and MACE. RESULTS: Of the 770 @entity583 @entity1 treated with primary PCI, in-hospital major @entity548 occurred in 32 (4.2%) @entity1 . Independent pre-dictors of major @entity548 were advanced age (>=  65 years), female gender, baseline @entity417 and @entity1503 (WBC) count and signs of @entity712 at admission (Killip class II-IV). In-hospital and 6 month mortality and MACE, rates were more than 2.5-fold-higher in @entity1 who developed major @entity548 compared with those who did not. @entity548 was predictor of 6-month MACE, independent of a few risk factors (previous MI, previous PCI, @entity6 and @entity101 ); (OR = 3.02; 95% CI for OR 1.20-7.61; p = 0.019) but was not a true independent predictor of MACE and mortality in the fully adjusted models. CONCLUSION: @entity1 of advanced age, female gender, with baseline @entity417 and elevated WBC count and those with Killip class II-IV at presentation are at particularly high risk of @entity548 after primary PCI. Bleeding is associated with adverse outcome and may be an important marker of @entity1 frailty, but it is not a true independent predictor of mortality/MACE.
