Dysfunction of XXXX in Decidua: Possible Relevance to the Pathogenesis of @entity1468 .

@entity1 @entity1841 @entity2538 @entity66 @entity18182 @entity10116 @entity20043 @entity1468
UNASSIGNED: @entity1468 ( @entity1468 ) is a @entity66 unique to @entity1 that is known to cause maternal and perinatal mortality and morbidity. Between 5-7% of all pregnancies are affected by @entity1468 and it is responsible for approximately 50,000 maternal deaths annually. The pathogenesis of @entity1468 remains poorly understood. However, the results of this study indicated that insufficient decidualization plays a significant role. @entity20043 and @entity2538 are orphan members of the @entity20043 subfamily of nuclear receptors and are involved in @entity1 follicular development, female reproduction, steroidogenesis, and decidualization. The expression of @entity20043 and @entity2538 in the @entity1 decidua and their functions during decidualization were investigated using in vitro cultured cells by real-time PCR, immunohistochemistry, western blotting, and siRNA techniques. The results demonstrated that the levels of @entity2538 mRNA and protein in the decidual tissues of @entity1 with @entity1468 were lower than those of normal pregnant @entity1 . However, the levels of @entity20043 mRNA and protein did not significantly differ between groups. The expression of @entity2538 was upregulated after in vitro decidualization, but the expression of @entity20043 remained low and showed no difference compared with that of the control cells. Knocking down of @entity2538 in @entity1 endometrial stromal cells (hESC) resulted in a significant reduction in their expression of decidualization markers ( @entity10116 and PRL) and signaling pathway molecules ( @entity18182 and @entity1841 ) (P < 0.05). From these data, we concluded that @entity2538 is pivotal for the decidualization of decidual tissues and cultured @entity1 endometrial stromal cells. Disorders of the endometrium in decidual tissues may be associated with the abnormal decidualization thought to cause @entity1468 .
