Effects of @entity1891 in combination with @entity1499 and other antitumor agents in @entity1 XXXX cells in culture.

@entity1 @entity981 @entity5699 @entity5 @entity4445 @entity9864 @entity1500 @entity1891 @entity1732 @entity1499 @entity5713
The effects of @entity1891 (VCR) in combination with @entity1499 ( @entity1500 ) and other antitumor agents were evaluated by cell growth inhibition assay using a @entity1 @entity981 cell line (MOLT-3). The data were analyzed with the aid of an isobologram using the concept of an envelope of additivity (G. G. Steel and M. J. Peckman, Int. J. Radiat. Oncol., 5:85-91, 1979). Simultaneous exposure of VCR and @entity1500 produced subadditive or mutually protective interactions. Sequential exposure to VCR first followed immediately by @entity1500 produced similar interactions. When the interval of VCR exposure first and then @entity1500 was increased from 0 to 3, 8, and 24 h, the inhibition of cell growth moved from protection and subadditivity to additivity only. The reversed order of exposure to the 2 drugs produced an entirely different picture. Thus, when the interval of @entity1500 exposure first followed by VCR increased from 0 to 3, 8, and 24 h, the inhibitory effects of the combination changed progressively from the area of subadditivity to the area of supraadditivity. When these data were evaluated using median effect plot analyses (T-C. Chou and P. Talalay. In: New Avenues in Developmental @entity5 Chemotherapy, pp. 36-64. Orlando, FL: Academic Press, 1987), strongly synergistic interaction of this sequence at space intervals was confirmed. These data show that the synergistic effects were produced only when @entity1500 was followed 8 or 24 h later by VCR. Other schedules were only additive or even antagonistic. Simultaneous exposure of VCR with @entity5699 , @entity9864 , or @entity1732 also had subadditive and protective effects. VCR, followed by @entity5699 with the interval of 24 h and vice versa, was again subadditive and protective. VCR, followed by @entity9864 with the interval of 24 h and vice versa, was again subadditive or additive only. Simultaneous and continuous exposures of VCR with @entity5713 or @entity4445 were only marginally supraadditive.
