The importance of @entity417 in cerebral and uncomplicated @entity9231 : role of complications, @entity11407 and XXXX sequestration.

@entity1 @entity417 @entity648 @entity2348 @entity102 @entity9231 @entity11407 @entity5861 @entity6197 @entity1011 @entity68
Ninety-four per cent of 169 @entity1 with @entity6197 developed @entity417 (haematocrit less than 35 per cent) and 30 per cent required blood transfusion to maintain the haematocrit at more than 21 per cent. @entity417 was at its worst on admission in 58 @entity1 (34 per cent); in the rest the haematocrit fell further, reaching its nadir one to 17 days later (mean 2.3 days). The mean lowest haematocrit was 24.3 +/- 7.2 per cent (+/- 1 SD) and the mean maximum fall was 7.9 +/- 5.6 per cent. @entity417 was more severe in @entity1 with @entity2348 , @entity5861 , schizontaemia and in pregnancy. The lowest haematocrit correlated with admission parasitaemia (r = -0.33, p less than 0.001), total serum @entity648 (r = -0.25, p less than 0.01) and serum @entity1011 (r = -0.22, p less than 0.01). In 23 @entity1 with uncomplicated @entity9231 the mean serum @entity68 on admission was 53 micrograms/dl (range 16-157) and the mean serum ferritin 1773 ng/ml (range 170-10 000). There was a significant (p less than 0.001) rise in serum @entity68 96 h after starting antimalarial treatment; the serum ferritin declined slowly over several weeks. Stainable @entity68 was present in all marrows examined and in eight @entity1 the characteristic pattern of the @entity417 of @entity102 was seen. Seventy-three per cent of @entity1 had @entity11407 which was moderate to gross in 36 per cent. @entity11407 and erythrophagocytosis were often present on admission but sometimes appeared after the parasitaemia had cleared and persisted for at least three weeks into convalescence. These disturbances in @entity68 metabolism and haemopoiesis are not completely explicable by red blood cell parasitisation. They may contribute more to the @entity417 than has previously been recognised.
