Altered long- and short-range functional connectivity in the XXXX with @entity454 : a resting-state functional MRI study.

@entity1 @entity2597 @entity1133 @entity75 @entity73 @entity1011 @entity1985 @entity454
To investigate alterations of @entity2597 ( @entity2597 ) in @entity1 with @entity454 ( @entity454 ) by using resting-state functional magnetic resonance imaging (rs-fMRI). Medical research ethics committee approval from Jinling hospital and written informed consent from each subject were obtained. Forty six @entity1 with @entity454 , consisting of 21 @entity1 minimal @entity1985 (MNE) and 25 non-nephro- @entity75 (non-NE), as well as 23 healthy controls underwent rs-fMRI. Neuropsychological tests were performed in all subjects, while laboratory tests were performed in @entity454 @entity1 . A voxel-wise whole brain functional connectivity analysis was used to generate long- and short-range @entity2597 maps. The maps among MNE, non-NE, and healthy controls groups were compared by using one-way analysis of variance tests. A multiple regression analysis was performed to evaluate the correlations between @entity2597 and the variables of neuropsychological or laboratory tests. Compared with healthy controls, non-NE showed decreased long-range @entity2597 mainly in parietal lobe. Moreover, MNE showed further decreased long-range @entity2597 in bilateral middle prefrontal cortex (MPFC), anterior cingulate cortex (ACC) and right superior frontal gyrus. Meanwhile, non-NE showed decreased short-range @entity2597 mainly in frontal cortex, and further reduction in bilateral ACC and right superior parietal gyrus in MNE. In addition, @entity1 with @entity454 mainly exhibited increased long-range @entity2597 in left temporal lobe and caudate; and increased short-range @entity2597 in bilateral orbitofrontal cortex and temporal gyri (P  <  0.05, AlphaSim corrected). The number connection test type A score, serum @entity1011 , @entity1133 , and dialysis duration showed negative correlation with @entity2597 in some brain regions, while the digital symbol test scores positively correlated with short-range @entity2597 in left inferior parietal lobule (all P  <  0.05, AlphaSim corrected). The prominent long- and short-range @entity2597 reduction was found mainly in default mode network (DMN) and bilateral frontal and parietal lobes, while the progressively decreased long- and short-range @entity2597 in ACC/MPFC and the long-range @entity2597 in left superior frontal gyrus from non-NE to MNE was associated with @entity73 in @entity454 @entity1 .
