In vivo and in vitro sensitization to domestic mites in German urban and rural allergic XXXX .

@entity1 @entity7130 @entity565 @entity2490 @entity1729
Sensitization to domestic mites is common in Germany. The main objectives of this study were (1) to establish the rate of skin test sensitivity to @entity7130 , Acarus siro, Lepidoglyphus destructor, and Tyrophagus putrescentiae in 512 consecutive @entity1 evaluated for @entity1729 ; (2) to verify how many of the @entity1 with a positive skin test to at least one of the three storage mites were also skin test positive to @entity7130 ; and (3) to verify how many of the @entity1 with at least one positive skin test to one of the storage mites previously mentioned were also sensitized, in vitro, to other mite species. A total of 512 consecutive @entity1 with @entity2490 and/or @entity565 , living in urban or rural areas of central Germany were skin tested with extracts of @entity7130 , A. siro, L. destructor, and T. putrescentiae. In addition, specific IgE determinations to Euroglyphus maynei, Blomia tropicalis, Blomia tjibodas, Blomia kulagini, and Gohieria fusca were conducted in those individuals with a positive skin test to at least one of the storage mites used in skin testing. Of the 512 @entity1 , 103 (20.1%; 77 urban dwellers and 26 farmers) reacted to at least one of the storage mites. From this latter group, 88 individuals (85.4%) also skin tested positive to @entity7130 . In vitro specific IgE determinations revealed a high rate of sensitization to the other mite species studied. We conclude that sensitization to storage mites in Germany is frequently associated with sensitivity to @entity7130 . Overall, skin test sensitivity to storage mites was greater in rural than in city dwellers. In vitro sensitization to B. tjibodas was also significantly greater in rural than in city dwellers.
