Prolonged QTc as a predictor of mortality in acute XXXX .

@entity1 @entity1162 @entity204 @entity385
OBJECTIVE: We sought to examine the relationship of the QTc interval with mortality and functional outcome after acute @entity385 , and determine whether a threshold cutoff is present beyond which risk of @entity204 increases. METHODS: The QTc interval was measured for all @entity1 presenting to the emergency department. The outcomes were mortality at 90 days and functional outcome at hospital discharge. The cutoffs were determined plotting martingale residuals. RESULTS: @entity1 with a @entity1162 were more likely to die within 90 days compared with @entity1 without a prolonged interval (relative risk [RR] 2.5; 95% confidence interval [CI] 1.5-4.1; P < .001). The estimated survival at 90 days was 70.5% and 87.1%, respectively. This association retained statistical significance after adjusting for age and National Institutes of Health Stroke Scale score (RR 1.7; 95% CI 1.0-2.9; P = .043). @entity1 with a @entity1162 were also more likely to have poor functional status compared with @entity1 without a prolonged interval (odds ratio 1.8; 95% CI 1.2-3.0; P = .006). This association was not statistically significant after adjusting for age and National Institutes of Health Stroke Scale score (odds ratio 1.2; 95% CI 0.7-2.4). The identified threshold cutoffs for increased risk of @entity204 at 90 days were 440 milliseconds for @entity1 and 438 milliseconds for @entity1 . CONCLUSION: There appears to be an increased risk of @entity204 in @entity1 with acute @entity385 and a @entity1162 at the time of emergency department presentation. Prognosis appears to be worse with QTc intervals longer than 440 milliseconds in @entity1 and longer than 438 milliseconds in @entity1 .
