Splenectomy exacerbates @entity82 and vulnerability to @entity955 induced by pressure overload in XXXX : Possible role of spleen-derived @entity13358 .

@entity1601 @entity32 @entity82 @entity13358 @entity955 @entity299 @entity35 @entity583
BACKGROUND: The spleen is important for @entity299 induced by @entity583 . However, the role of the spleen in @entity82 induced by pressure overload is unknown. OBJECTIVE: The purpose of this study was to investigate whether splenectomy ( @entity1601 ) attenuates or exacerbates pressure overload-induced @entity82 and vulnerability to @entity955 ( @entity955 ) in @entity35 . METHODS: Male @entity35 (6 weeks old) were divided into Sham+Sham, Sham+ @entity1601 , abdominal aortic constriction (AAC)+Sham, and AAC+ @entity1601 groups, and were evaluated for @entity32 , @entity82 , and @entity955 on days 2, 4, 14, and 28. RESULTS: On day 4, an AAC-induced rise in @entity13358 ( @entity13358 ) level was observed in the spleen, serum, and left atrium (LA), with @entity1601 showing inhibitory effects in the latter 2 instances. In addition, AAC-induced M2 macrophage recruitment into the LA was decreased by @entity1601 , as determined by immunofluorescence labeling (P <.05). On day 28, AAC-induced heterogeneous @entity82 of the LA was enhanced by @entity1601 (P <.05). Electrophysiologic recordings revealed that the duration of @entity955 and prolongation of interatrial conduction time induced by AAC were increased by @entity1601 (P < .01 and P <.05, respectively). Furthermore, in the AAC+ @entity1601 group, the number of macrophages infiltrating into the LA on day 2 was marginal, but increased on day 28 relative to the AAC+Sham group. @entity13358 administration attenuated the AAC-induced atrial remodeling that was aggravated by @entity1601 . CONCLUSION: The study results suggest that @entity1601 exacerbates AAC-induced @entity82 and increases vulnerability to @entity955 after 4 weeks, likely because of depletion of spleen-derived @entity13358 .
