XXXX (CD 105) as a potential prognostic factor in @entity521 .

@entity1 @entity6459 @entity5 @entity521 @entity3 @entity4180
BACKGROUND: @entity6459 (CD105) is a cytokine that modulates angiogenesis by regulating different cellular functions, including endothelial proliferation, differentiation, migration and formation of microvessels. CD105 is expressed strongly in the @entity5 vasculature, and intratumoral microvessel density (IMVD), as determined by the use of antibodies to CD105, it has been found to be an important prognostic indicator for outcome in various malignances. This study aims to determine if the clinical outcome of @entity1 with @entity521 is correlated with IMVD, as determined by CD105 staining and other prognostic factors. PROCEDURE: Tumor tissue specimens from 38 @entity1 with peripheral @entity5 who underwent surgical resection or biopsy of their @entity5 without any preoperative therapy were retrospectively reviewed. IMVD was identified immunohistochemically using monoclonal antibodies against CD105. Prognostic factors, such as the @entity4180 oncogene, disease stage, histopathology and age, were correlated with outcome. RESULTS: Among 38 examined specimens, the median IMVD value was 23.2 (15.1-28.4). The IMVD identified by CD105 was significantly higher in @entity1 with unfavorable histology, @entity3 , @entity4180 amplification and COG high risk group. ROC analysis was used to find significant IMVD level regarding EFS. The cut-off >18 was selected according to the greatest sensitivity (100%) and specificity (68.42%). The multivariate Cox proportional hazards analysis demonstrated that @entity4180 amplification and IMVD were significant prognostic factors in predicting EFS (hazard ratio for @entity4180 amplification: 3.61; 95% CI: 1.20-10.90; P   =   0.023 and for IMVD: 1.05; 95% CI: 1.00-1.09; P   =   0.037). CONCLUSION: IMVD determined by CD105 appeared to be an independent prognostic factor for @entity521 . Pediatr @entity5    2015 Wiley Periodicals, Inc.
