XXXX in young adults: incidence, disease outcome and review of the literature.

@entity1 @entity8 @entity1803 @entity5 @entity1358 @entity3
OBJECTIVE: To study the incidence, clinical presentation and pathological prognostic factors affecting disease outcome of @entity1358 in young adults less than 40 years old. METHODS: The charts o medical records of 400 @entity1 treated surgically for @entity1358 between January 1984 and December 1999 were reviewed. 29 (7.25%) @entity1 were under 40. We used ANOVA regression and Chisquare (Fisher exact test) to assess the prognostic value of the quantitative and qualitative variables, respectively. Estimation of the survival distributions were calculated according to Kaplan-Meier method and compared with Log rank test. Multivariate analysis of the entire population utilizing Cox models was performed. RESULTS: The most common histological cell type was @entity1358 , found in 20 (69%) @entity1 . At a median follow-up of 80 months, 20 (69%) @entity1 were disease free and 9 (31%) died of the disease. Incidental discovery (p = 0.05), @entity5 stage (p = 0.043), grade (p = 0.011), lymphatic invasion (p < 0.0001) @entity3 (p = 0.003), adrenal invasion (p = 0.024), and @entity8 (p < 0.0001) were associated with prognosis (Kaplan-Meier). When comparing @entity1 less than 40 years vs. older than 40 years, we found significant differences in histology type ( @entity1358 69% vs. 91%; p = 0.0001), and @entity5 stage at presentation (pT2 = 34.5% vs. 17.3%; p = 0.04) ( @entity1803 = 20.7% vs. 42%; p = 0.03). Disease free survival was not significantly different between the two groups (69% vs. 65.7%; Log rank test p = 0.4). CONCLUSION: Although rare, @entity1358 in young adults seems to follow a course similar to the disease seen in older @entity1 . Among the prognostic factors studied incidental discovery, pathological stage of the @entity5 and grade, were associated with survival. Stage at presentation was different between the two populations however survival was not affected by age.
