The effect of @entity1063 versus @entity1425 in irrigation fluid on the incidence of XXXX /bradycardic events during arthroscopic rotator cuff repair with interscalene block in the sitting position.

@entity1 @entity227 @entity1425 @entity551 @entity954 @entity1063
PURPOSE: To compare the occurrence rate of @entity551 and bradycardic events (HBEs) during arthroscopic rotator cuff repair performed with interscalene brachial plexus block anesthesia in the sitting position in 2 groups of @entity1 who underwent the procedure with @entity1063 or @entity1425 added to the irrigation fluid. The secondary objective was to evaluate the efficacy of @entity1063 in comparison with @entity1425 in controlling @entity954 and maintaining adequate visualization of the arthroscopic field of view during the procedure. We hypothesized that @entity1063 added to the irrigation fluid during shoulder arthroscopy in the sitting position would reduce the occurrence of HBEs, allowing optimal @entity954 control. METHODS: One hundred twenty @entity1 underwent an arthroscopic rotator cuff repair performed under peripheral anesthesia and in the beach-chair position. @entity1 were randomly divided into 2 groups of 60 cases each: @entity1063 (0.66 mg/L) and @entity1425 (0.33 mg/L) were added to irrigation bags in group N and group E, respectively. The primary outcome was the occurrence rate of HBEs during surgery. The secondary outcomes were timing of onset of HBEs, accompanying symptoms, and @entity954 that @entity227 . The clarity of the visual field was rated postoperatively by the surgeon using a visual analog scale. Comparison between groups for all baseline variables and outcome measurements was performed with the   (2) or Fisher exact test, as appropriate, for categorical variables and the Student t test or Mann-Whitney U test, as appropriate, for continuous variables. Significance was set at P < .05. RESULTS: One @entity1 was excluded from group E because of block failure; therefore 119 @entity1 were finally included in the study. Comparison between groups showed no significant differences in baseline characteristics. The occurrence rate of HBEs was significantly greater in group E (n  = 15) than in group N (n  = 5) (P  = .02). No differences between groups were found in the average time of onset of HBEs, accompanying symptoms, and clarity of the visual field. CONCLUSIONS: Continuous administration of @entity1063 , 0.66 mg/L, diluted in irrigation fluid during arthroscopic rotator cuff repair with the @entity1 in the beach-chair position reduces the incidence of HBEs and is as effective as @entity1425 in controlling @entity954 and maintaining the visual clarity of the surgical field. LEVEL OF EVIDENCE: Level I, randomized clinical study.
