[Immunoregulatory role of gamma delta T cell receptor in XXXX --association with the IgE response to molds antigen].

@entity565 @entity1097 @entity12131 @entity6057
To evaluate the role of gamma delta T cells in @entity12131 , we examined the relationship among @entity565 , and genetic polymorphism of the gamma chain of @entity6057 ( @entity6057 ) in families through @entity1097 . We recruited 5 families (69 subjects). Total serum IgE levels were estimated by a radioimmunosorbent test (IgE RIST). Skin prick tests were done with inhaled allergens consisting of house dust, grass and tree pollens, common molds, and animal danders. Antigen-specific IgE levels in response to these allergens were also measured by multiple antigen simultaneous test (IgE MAST). The @entity1097 phenotype was determined by the presence of a positive skin test, an elevated antigen specific IgE value, an elevated total IgE level, or some combination of these. Although linkage of @entity565 to the gene encoding the gamma chain of @entity6057 was excluded, the lod score between this gene and molds-specific IgE responses was 0.42 at the recombination fraction of 0.1. In an association study, a 19 kb allele of the gamma chain of the @entity6057 gene was found more frequently in asthmatic subjects than in non-asthmatic subjects (p = 0.068). Also, molds-specific IgE responses were significantly associated with this allele (p = 0.018). These findings suggest that molds-specific IgE responses underlying @entity12131 are partly regulated by the gene encoding the gamma chain of the @entity6057 .
