Comparing biomarkers of traumatic shock: the utility of anion gap, base excess, and serum XXXX in the ED.

@entity1 @entity1457 @entity880 @entity130
BACKGROUND: Biomarkers such as serum @entity880 , anion gap (AG), and base excess (BE) have been shown to be of use in determining shock in @entity1 with seemingly normal vital signs. We seek to determine if these biomarkers can be used interchangeably in @entity1 with @entity130 in the emergency setting based on their test characteristics and correlation to each other. METHODS: A prospective observational cohort study was undertaken at an urban level 1 @entity130 center. Baseline vital signs, point-of-care BE, AG, and serum @entity880 were recorded in all @entity1 who presented for @entity130 . Correlation was determined by linear regression model. Overall test characteristics and relative risk were calculated. RESULTS: One hundred @entity1 were enrolled. The median age was 30 years (interquartile range, 24-42 years), and 89% were male. Fifty-three percent of injuries were @entity130 . Pearson correlation of serum @entity880 to BE was -0.81 (r(2) = 0.66; 95% confidence interval [CI], 0.53-0.75; P < .001), that of BE to AG was -0.71 (r(2) = 0.5; 95% CI, -0.80 to -0.57; P < .01), and that for serum @entity880 to AG was 0.71 (r(2) = 0.5; 95% CI, 0.57-0.80; P < .01). CONCLUSIONS: This study demonstrates that the biomarkers have similar test characteristics which may make them interchangeable as indicators for the presence of @entity1457 in @entity1 with @entity130 . @entity880 and BE correlate well with each other; however, AG was not as strongly correlated with either.
