Cell kinetics of the malignant evolution of XXXX .

@entity1 @entity1603 @entity1653 @entity5
A @entity1653 occurred in the right parietal parasagittal region of a 43-year-old @entity1 . A total excision was carried out. Three years and 9 months later, one parasagittal and two @entity5 in close proximity recurred and were excised. The @entity5 showed the features of an anaplastic transitional @entity1653 with increased mitoses. The @entity1653 recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the @entity5 was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, @entity1603 ( @entity1603 ) was administered intravenously to label @entity5 cells in the S phase of the cell cycle. The @entity1603 -labeled cells accounted for 9.0%; they are usually less than 1% in @entity1653 . @entity1653 with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a @entity5 should be instituted.
