Surfactant protein-D and surfactant inhibit endotoxin-induced XXXX .

@entity1 @entity32 @entity55 @entity19 @entity9914 @entity358 @entity24526 @entity647
BACKGROUND: @entity647 is a common cause of morbidity and mortality following @entity358 . Surfactant protein-D is a member of the collectin family of proteins, which play important roles in innate host defense of the lung. In this study, the effect of exogenous recombinant @entity1 @entity9914 (rhSP-D) on protection of the adult @entity19 lung from lipopolysaccharide (LPS)-induced and lipoteichoic acid (LTA)-induced injury was assessed. METHODS: The effect of rhSP-D on LPS-induced and LTA-induced @entity55 and injury was assessed with and without exogenous pulmonary surfactant in @entity24526 +/+ and @entity24526 -/- @entity19 . A total of 204 @entity19 (6 @entity19 per group) were used for the present study. RESULTS: @entity24526 -/- @entity19 were more susceptible to intratracheal LPS than were @entity24526 +/+ @entity19 . rhSP-D decreased neutrophilic infiltrates induced by LPS and LTA in the lungs of both @entity24526 +/+ and @entity24526 -/- @entity19 . The addition of exogenous pulmonary surfactant to rhSP-D further decreased LPS-induced and LTA-induced @entity55 in @entity24526 -/- and @entity24526 +/+ @entity19 . CONCLUSIONS: Intratracheal rhSP-D inhibited @entity32 induced by intratracheal LPS and LTA instillation in the lung. The antiinflammatory effects of rhSP-D were enhanced by the addition of pulmonary surfactant, providing a potential therapy for the treatment of @entity55 .
