@entity3676 in a decongestant nasal spray aggravates XXXX in healthy volunteers.

@entity3676 @entity11027 @entity2490 @entity112
A randomized double-blind parallel study with 20 healthy volunteers was performed to research the effect of a preservative in a decongestant nasal spray on the development of @entity2490 . Ten subjects received @entity11027 nasal spray with @entity3676 and the others used @entity11027 nasal spray without the preservative three times daily for 30 days. Before starting the course of treatment and after its conclusion, recordings of the mucosal surface positions were made with rhinostereometry followed by @entity112 challenge tests. Symptoms of nasal stuffiness were estimated on visual analogue scales (0-100) in the morning and the evening just before using the nasal spray. After 30 days, rebound swelling and nasal stuffiness were found in both groups. In the group receiving @entity11027 nasal spray with @entity3676 the mean rebound swelling was 1.1 mm and the estimated mean evening symptom score for nasal stuffiness was 43. In the group without @entity3676 the corresponding variables were significantly less marked, with a mean rebound swelling of 0.5 mm (P < 0.05) and a mean evening symptom score of 25 (P < 0.05). The increase in @entity112 sensitivity in both groups was interpreted as a sign of nasal hyperreactivity. A new type of nasal spray bottle was used that has been shown to prevent bacterial contamination. In conclusion, the long-term use of @entity3676 in @entity11027 nasal spray accentuates the severity of @entity2490 in healthy volunteers.
