[Impact of 24-hour intraesophageal pH monitoring with 2 channels in the diagnosis of reflux-induced XXXX ].

@entity1 @entity7552 @entity1537 @entity1127 @entity738 @entity2910 @entity1109 @entity14696 @entity7364 @entity357 @entity42090 @entity356 @entity1282 @entity354 @entity158 @entity12120 @entity3137
BACKGROUND: @entity1 with @entity354 ( @entity354 ) may suffer from a large variety of symptoms in the upper aerodigestive tract such as globus sensation, chronic cough, hoarseness and many others. Diagnosis and causal therapy may sometimes be difficult with gastroenterologic evaluation sometimes revealing no pathologic result. The objective of this study was to determine the impact of 24-hour intraesophageal pH monitoring with 2 channels (gastric and laryngeal) in the diagnosis of reflux-induced @entity14696 . METHODS: This study included 22 @entity1 presenting to the Department of Otolaryngology with symptoms like chronic cough (n = 3), globus sensation and @entity1282 (n = 11), heartburn (n = 2), hoarseness and @entity7364 (n = 2) or burning sensation of the tongue (n = 1). Three @entity1 had a pathologic formation in the glottic area ( @entity12120 , @entity738 , @entity1127 ). All @entity1 underwent a otolaryngological examination, a gastroenterological investigation and a 24-hour intraesophageal pH monitoring with 2 channels. RESULTS: All 22 @entity1 showed @entity3137 (posterior @entity7552 ). The gastroenterological evaluation with esophagogastroduodenoscopy was normal in 4 cases. 13 @entity1 showed a @entity357 , 4 @entity1 were suffering from a reflux- @entity2910 grade I and 2 @entity1 from grade II. One @entity1 had an erythema and 5 @entity1 showed @entity356 . Seven @entity1 had more than one of the above mentioned diagnoses. Intraesophageal pH-monitoring with 2 channels over 24 hours revealed a gastroesophageal reflux of all 22 @entity1 and a high reflux to the laryngeal level of 21 @entity1 , probably causing laryngopharyngeal symptoms. Therapy of the @entity1 consisted of medical antireflux treatment with proton pump inhibitor @entity42090 ( @entity1537 , 40 mg, 1-0-0). Within 4 weeks 15 of 22 @entity1 had no more laryngopharyngeal symptoms or at least a significant reduction. CONCLUSION: @entity1 with laryngopharyngeal symptoms such as @entity1109 or @entity1282 can suffer from @entity354 , even if typical symptoms such as heartburn or @entity158 do not exist and gastroesophageal intervention reveals a normal result. The best diagnostic instrument for the diagnosis of reflux-induced @entity14696 is a 24-hour intraesophageal pH-monitoring with 2 channels (measure-points at the distal esophagus and laryngeal level). Medical antireflux treatment should consist of proton pump inhibitors (e. g. @entity1537 ) in a dose of 40 mg per day over at least 4 weeks.
