Effect of corticosteroid on lung parenchyma remodeling at an early phase of XXXX .

@entity1667 @entity230 @entity6453 @entity228 @entity30236 @entity35 @entity647
In vivo (lung resistive and viscoelastic pressures and static elastance) and in vitro (tissue resistance, elastance, and hysteresivity) respiratory mechanics were analyzed 1 and 30 days after saline (control) or @entity6453 (P [10 and 25 mg/kg intraperitoneally]) injection in @entity35 . Additionally, P10 and @entity30236 were treated with @entity1667 (2 mg/kg intravenously) at 1 or 6 hours after @entity647 ( @entity647 ) induction. Collagen and elastic fibers were quantified. Lung resistive and viscoelastic pressures and static elastance were higher in P10 and @entity30236 than in the control. Tissue elastance and resistance augmented from control to P10 (1 and 30 days) and @entity30236 . Hysteresivity increased in only @entity30236 . @entity1667 at 1 or 6 hours attenuated in vivo and in vitro mechanical changes in @entity30236 , whereas P10 parameters were similar to the control. Collagen increment was dose and time dependent. Elastic fibers increased in @entity30236 and at 30 days in P10. @entity228 prevented collagen increment and avoided elastogenesis. In conclusion, @entity1667 led to a complete maintenance of in vivo and in vitro respiratory mechanics in mild lesion, whereas it minimized the changes in tissue impedance and extracellular matrix in severe @entity647 . The beneficial effects of the early use of @entity230 in @entity647 remained unaltered at Day 30.
