Hepatocyte proliferative activity in @entity1 XXXX .

@entity1 @entity82 @entity1364 @entity1042 @entity2533 @entity982 @entity1575
BACKGROUND/AIMS: The objective of this study was to validate, with an independent prospective cohort of @entity1 , our previous data indicating that the proliferating cell nuclear antigen-labeling index ( @entity1364 -LI) reflects the liver functional reserve in @entity1 @entity82 and might have prognostic significance for @entity1 survival. We also examined how this proliferative index is related to the expression of @entity2533 ( @entity2533 ) as a possible correlate of hepatocyte proliferative activity. METHODS: The present group (n=70 @entity1 ) was similar in composition to our previous group regarding age, sex and severity of @entity1575 . @entity1364 and @entity2533 immunostaining were analyzed on @entity1042 -fixed, @entity982 -embedded liver biopsies. RESULTS: Our data show that @entity1364 -LI declined significantly with worsening @entity1 class and was negatively correlated with the Pugh score. Twenty-five @entity1 died and 10 underwent liver transplantation during the observation period. Liver function, hepatic venous pressure gradient and hepatocyte @entity1364 -LI were significantly different in survivors and non-survivors. At a mean follow-up of 356 days, the @entity1 with a @entity1364 -LI higher than 4.4% (the previously determined best cut-off value) had a significantly higher probability of survival than those with a @entity1364 -LI < or = 4.4% (0.87 vs 0.48, p=0.0009). @entity2533 expression in liver parenchyma correlated negatively with @entity1364 -LI, suggesting that this cytokine could be involved in the impaired regeneration observed in worsened @entity1575 . CONCLUSIONS: This prospective study strengthens our previous observation that, in @entity82 , hepatocyte proliferative activity, as evaluated by the @entity1364 -LI, provides information on liver functional reserve as well as on the @entity1 's prognosis.
