@entity2204 may increase viral load and @entity410 frequency in XXXX @entity1 with positive @entity1 herpes virus 6B.

@entity1 @entity410 @entity2204 @entity1315 @entity780
UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.
