[Risk factors for XXXX , @entity2259 , and @entity293 in an intensive care unit].

@entity1 @entity55 @entity5 @entity281 @entity580 @entity2259 @entity293
BACKGROUND: To identify nosocomial @entity281 risk factors in an intensive care unit and construct a predictive model that will enable future risk-adjusted comparisons of @entity281 incidences. @entity1 AND METHODS: Prospective surveillance of @entity55 , @entity2259 and @entity293 in intensive care unit @entity1 . All @entity1 (n = 944) admitted to the intensive care unit for at least 24 h were followed daily in a tertiary level hospital. Variables measuring extrinsic as well as intrinsic risk factors for @entity580 were collected from each @entity1 during their intensive care unit stay and the Cox proportional hazards multivariable technique was applied to identify the variables mostly associated with @entity281 in our hospital. RESULTS: The main risk factors identified for @entity55 were intrinsic. The hazard ratios (HR) of two extrinsic risk factors were noteworthy: mechanical ventilation (HR = 7.51; 95% CI = 2.95-19.13) and sedation (HR = 2.01; 95% CI = 1.14-3.56). The extrinsic factors associated with @entity2259 were, the sum of extrinsic risk factors (HR = 1.52; 95% CI = 1.17-1.97) and having a tracheostomy (HR = 3.61; 95% CI = 1.99-6.56). The @entity293 were negatively associated with the administration of antibiotics prior to @entity281 onset (HR = 0.41; 95% CI = 0.21-0.78) and the male sex (HR = 0.40; 95% CI = 0.22-0.75). Conversely, @entity293 were positively associated with the presence of @entity5 (HR = 2.70; 95% CI = 1.03-7.11) and the APACHE II index (for every 5 units of increase of the APACHE II index, HR = 1.39; 95% CI = 1.09-1.79). CONCLUSIONS: The most important risk factors identified for @entity55 and @entity293 in intensive care unit @entity1 were endogenous, whereas they were exogenous for @entity2259 .
