The sensitization of mucosal mast cells during @entity281 with Trichostrongylus colubriformis or @entity5167 in XXXX .

@entity742 @entity1139 @entity281 @entity112 @entity5167
Responses of isolated mucosal mast cells ( @entity1139 ) during @entity281 with either Trichostrongylus colubriformis or @entity5167 were examined by measuring the release of @entity742 mast cell protease (SMCP) in a degranulation assay. @entity1139 from @entity742 immune to T. colubriformis released maximal amounts of SMCP and @entity112 within 0.5h of incubation with larval antigen whereas maximum secretion of leukotrienes occurred 3h after addition of antigen. It was only after 8 weeks of a primary T. @entity281 , that @entity1139 released significantly elevated levels of SMCP (23%); this occurred when the worm burden was being rejected. In contrast, the SMCP release from @entity1139 of immune @entity742 was significantly higher at 40%, and occurred within 1-4 days after challenge (DAC). The SMCP release peaked at 6-8 DAC at 51%, and declined after 56 DAC to < 25%. @entity1139 isolated from the duodenum and mid-small intestine of immune @entity742 released 2-3 times higher proportion of SMCP than did cells recovered from the terminal ileum. Mast cell numbers were similar in the 3 regions but the quantity of globule leucocytes (GL) was 2.5 times higher in the duodenum. During @entity281 with @entity5167 in the abomasum, @entity1139 isolated from the small intestine released greater levels of SMCP when incubated with larval antigens than did abomasal @entity1139 . There was no increased release during the first 12 weeks of a @entity281 although the SMCP release (23%) from immune @entity1139 at 7-10 DAC was significantly enhanced. Once again the release from @entity1139 isolated from the three intestinal regions of @entity742 immune to @entity5167 was lowest in the terminal ileum.(ABSTRACT TRUNCATED AT 250 WORDS)
