Lung transplantation as the first choice in XXXX .

@entity1 @entity19621 @entity2348 @entity260 @entity2415 @entity281 @entity364 @entity4154 @entity2542 @entity3816
INTRODUCTION: The indication for single or double lung transplantation in @entity1 diagnosed with @entity2542 is a topic of current debate. Our aim was to analyze the differences in the incidence of perioperative complications, survival, and quality of life between single and double lung transplantations. MATERIALS AND METHODS: From 1999 to 2008, 223 subjects underwent transplantation in our department, of whom 62 (28%) had a previous diagnosis of @entity2542 . A retrospective study was performed to establish possible differences between group 1 (single lung) and group 2 (double lung) transplants analyzing overall survival using the Kaplan-Meier method and differences between groups using the log-rank test. Pearson chi-square test was used to compare the frequency of @entity260 , @entity4154 @entity19621 acute rejection episodes, and @entity281 . RESULTS: We included 62 @entity1 who underwent transplantation for @entity2415 . Cumulative 5-year survival rate, excluding preoperative mortality, was 54% overall, 59% for group 1, and 56% for group 2. No significant differences were observed between the groups (P = .47). The frequency of @entity19621 was 34% in group 1 and 42% in group 2 (P = .52). At least 1 acute rejection episode occurred in 52% of group 1 @entity1 and 51% of group 2 @entity1 (P = .98). @entity2348 were experienced by 50% of group 1 @entity1 and 54% of group 2 @entity1 (P = .72). @entity364 affected 10% of group 1 @entity1 and 15% of group 2 @entity1 (P = .71). @entity3816 were recorded in 27.6% of group 1 @entity1 versus 54% of group 2 @entity1 , a difference that was statistically significant (P = .032). CONCLUSIONS: The study results supported the decision of our group to consider single lung transplantation the treatment of choice in @entity2415 , which may be complemented with volume reduction surgery in the native lung or subsequent transplantation of the contralateral lung.
