Percutaneous CT-guided microwave ablation as maintenance after first-line treatment for XXXX with advanced @entity1149 .

@entity1 @entity55 @entity5 @entity1149 @entity1349
BACKGROUND: Systemic therapy is recommended for advanced @entity1149 ( @entity1149 ). However, conventional first-line treatment has generated a plateau in response rate of 25% to 35%. Few studies have shown @entity1 benefit from microwave ablation (MWA) in combination with radiotherapy and chemotherapy. This study aims to evaluate safety and efficacy of percutaneous computed tomography-guided MWA as maintenance after first-line treatment for @entity1 with advanced @entity1149 . METHODS: @entity1 with histologically verified @entity1149 stage IIIB or IV between January 2010 and March 2014 were involved. After completion of first-line treatment with partial response or stable disease, 35 @entity1 with 39 @entity5 underwent 39 MWA procedures. Complications, progression-free survival (PFS), @entity1349 ( @entity1349 ), and correlated predictors were analyzed. RESULTS: During a median follow-up of 17.7 months and 10.8 months after initial MWA, local efficacy was 87.2%, median MWA-related local control time was 10.6 months, and @entity5 size was the only predictor (P=0.002). Median MWA-related PFS, MWA-related @entity1349 , PFS, and @entity1349 were 5.4, 10.6, 11.8 and 17.7 months, respectively. Local efficacy was significantly correlated with MWA-related PFS (P=0.003), MWA-related @entity1349 (P=0.000), and @entity1349 (P=0.001). There were no procedure-specific deaths. Total incidence of major complications was 12.8%, including pneumothorax resolved by closed pleural drainage and @entity55 controlled by antibiotics in a short time. CONCLUSION: This study concluded two points, including: 1) @entity1 benefited from MWA as maintenance both in local control and survival; 2) as maintenance MWA was superior to conventional maintenance therapy with improved survival and well-tolerated complications. Therefore, MWA was a safe and effective maintenance after first-line treatment in @entity1 with advanced @entity1149 .
