Protective effects of XXXX on acute @entity788 in @entity35 .

@entity788 @entity4 @entity1827 @entity11344 @entity35 @entity8629 @entity12828
@entity1827 , a 21-residue peptide isolated from vascular endothelial cells, has a broad spectrum of actions. To clarify the involvement of @entity1827 in acute @entity788 , we examined the effects of @entity1827 and its receptor antagonist @entity11344 on @entity8629 -induced @entity788 in @entity35 . @entity35 were infused intravenously with heparin-saline (control), @entity1827 (100 pmol/kg/hr), @entity8629 (5 micrograms/kg/hr), or @entity8629 plus @entity1827 for 3.5 hr. In another experiment, @entity8629 or @entity8629 plus @entity11344 (3 mg/kg/hr) was infused. Infusion of @entity8629 caused @entity12828 and @entity4 . @entity1827 , when infused with @entity8629 , decreased the extent of @entity4 with a significant increase in the pancreatic dry- to wet-weight ratio. Histological changes induced by @entity8629 were markedly attenuated when @entity1827 was given with @entity8629 . In contrast, endothelin-receptor blockade with @entity11344 further augmented @entity4 caused by @entity8629 . The extent of inflammatory cell infiltration was greater than @entity11344 was given with @entity8629 . @entity1827 or @entity11344 had no influence on @entity12828 . This study suggests that @entity1827 has protective effects on experimental acute @entity788 .
