Plaque radiotherapy for selected XXXX : preliminary observations: the 2002 Montgomery Lecture, part 2.

@entity1 @entity1496 @entity41 @entity5 @entity2347 @entity189 @entity2694 @entity3 @entity320 @entity1491
PURPOSE: To describe the principles and preliminary results of plaque brachytherapy for selected @entity2694 . METHODS: A custom-designed @entity1496 -125 plaque, designed to deliver a target dose of 50 Gray, was placed surgically in the region from which an @entity2694 was partially resected. The mean dose to the target area was 50 Gray. The initial and follow-up @entity1 data were reviewed. RESULTS: Of the 8 @entity1 , the diagnosis was @entity2347 of the lacrimal gland (4 cases), orbital invasion by @entity1491 (2), orbital extension of @entity320 (1), and @entity189 (1). Of the 4 with @entity2347 , there was microscopic @entity41 after excision and orbital exenteration was considered. Three have @entity5 control with follow-up of 1, 3, and 6 years. One @entity1 required exenteration for recurrence separate from the field of brachytherapy and is free of @entity5 after 10 years. All 4 @entity1 are alive and well with @entity5 control. Of the 2 @entity1 with orbital extension of @entity1491 , @entity5 control without recurrence has been achieved in both after 2 years. The @entity1 with orbital @entity3 responded to plaque radiotherapy, with no orbital recurrence, but died of systemic @entity3 . The @entity1 with orbital @entity320 had local orbital recurrence separate from the area of irradiation and is currently being treated for systemic @entity3 . CONCLUSIONS: Based on preliminary observations, plaque radiotherapy appears to be a reasonable alternative to exenteration and external irradiation for selected @entity2694 .
