Erythropoietic drive is the strongest predictor of hepcidin level in adults with XXXX .

@entity1 @entity32 @entity21985 @entity3458 @entity1307 @entity68
Levels of hepcidin, a key modulator of @entity68 metabolism, are influenced by erythropoiesis, @entity68 , and @entity32 , all of which may be increased in @entity1 with @entity3458 ( @entity3458 ). The objectives of this study were to determine: 1) the variation in hepcidin level, and 2) the relative contribution of erythropoietic drive, @entity68 , and @entity32 to differences in @entity21985 level in an adult cohort with @entity3458 . In a prospective study, cross-sectional measurements of hepcidin, reticulocyte percentage, @entity1307 , ferritin, and high-sensitivity CRP were obtained. A regression tree analysis was used to measure the association between these interacting factors and hepcidin level. The cohort was comprised of 40 adults with @entity3458 . Median age was 26years, 68% were female, and all had HbSS. Hepcidin values ranged from 30ng/ml to 326ng/ml, with a median of 87ng/ml. Regression tree analysis demonstrated that reticulocyte percentage, @entity1307 , ferritin and hs-CRP all were associated with hepcidin. The highest hepcidin values were found in subjects with low reticulocyte percentage and @entity1307 . In conclusion, erythropoietic drive, @entity68 status, and @entity32 all contribute to variation in hepcidin level. The strongest contributor is erythropoietic drive. Future studies could determine whether suppression of erythropoiesis with chronic transfusion influences hepcidin level.
