Roles of the XXXX -dependent transcription factor @entity71156 in acute rejection after liver transplantation.

@entity71156 @entity99 @entity13200 @entity28630 @entity5467 @entity35 @entity1140
UNASSIGNED: Acute rejection is a serious and life-threatening complication of liver transplantation (LTx). @entity1140 ( @entity5467 ) is a potent immunosuppressant used in experimental and clinical transplantation. @entity71156 ( @entity71156 ) plays key roles as a transcription factor in the immune response. This study explored the role of @entity71156 in acute rejection after LTx using @entity5467 treatment. Here, LTx was performed in DA (RT1(n)) and Lewis (LEW) (RT1( @entity35 . The recipients were immunosuppressed with @entity5467 (1.5mg/kg/day subcutaneously) or saline. Liver grafts were harvested 1, 3, 5, 7, and 10days after LTx for histology, immunohistochemistry, western blotting and real-time PCR. Splenic mononuclear cells were activated with different doses of @entity5467 . The nuclear factor of activated T cells ( @entity28630 ) signal pathway and CD4+ T subset-related transcription factors were assessed. The results showed that @entity5467 treatment prolonged the survival of liver allografts in recipients, significantly attenuated @entity99 and improved liver function. @entity71156 expression in grafts was down-regulated after @entity5467 treatment. @entity5467 inhibited the expression of @entity71156 , @entity28630 , @entity13200 and RORyt in splenic mononuclear cells in vitro. In conclusions, our studies showed that @entity5467 attenuated acute rejection responses after LTx. This attenuation might depend on the @entity5467 - @entity28630 - @entity71156 signal pathway, which is crucial for the function of T helper subsets (Treg and Th17 cells) in acute rejection after LTx. These findings contribute to our understanding of the immune pharmacological mechanism of @entity5467 to prevent rejection in LTx @entity35 .
