@entity1372 load increases renal angiotensin type 1 receptors and decreases XXXX type 2 receptors.

@entity101 @entity1809 @entity1219 @entity1283 @entity1372 @entity1808 @entity2400 @entity1812 @entity35 @entity2827 @entity11083 @entity4338
The regulation of both angiotensin receptors and @entity1812 receptors during @entity1372 intake is poorly understood. We hypothesized that an altered balance between renal angiotensin type 1 ( @entity1809 ) receptors and @entity1812 type 2 (B2) receptors might contribute to an increase in blood pressure during periods of high- @entity1372 intake. We studied the effects of high- @entity1372 intake on renal @entity1809 receptors and B2 receptors in 5-6-week-old spontaneously @entity101 @entity35 (SHR) receiving high- @entity2827 (6% @entity1219 ) or mineral salts (10.5%, composition: 57% @entity1219 , 28% @entity4338 , 12% @entity2400 ) compared to those receiving a low- @entity1372 ( @entity1219 0.125%) diet for 10 weeks. Mineral salt intake was included due to its beneficial effects on blood pressure and @entity1283 . Receptor densities were measured by quantitative autoradiography. @entity1809 receptors were quantified using incubation with 125I-Sar1-Ile8- @entity1808 and displacement was measured with @entity11083 (10 micromol/l), whereas B2 receptors were quantified using 125I-HPP-icatibant and displacement was measured with icatibant (3 micromol/l). Compared to the SHR controls, a further increase in blood pressure occurred after 2 weeks in the 6% @entity1219 group and after 6 weeks in the mineral salt group. @entity1809 receptor density increased in the renal cortex by 41% (p<0.01) in the 6% @entity1219 group and by 26% (p<0.05) in the mineral salt group. B2 receptor density decreased in the renal medulla by 26% (p<0.01) in the 6% @entity1219 group, and decreased even more i.e., by 45% (p<0.001), in the mineral salt group. It was shown that a 6% @entity1219 or a 10.5% mineral salt loading was capable of increasing renal @entity1809 receptor density and decreasing renal B2 receptor density. An altered balance between these receptors might be associated with @entity101 under conditions of @entity1372 loading.
