Adjuvant Therapy for XXXX - A Decade of Experience in a Taiwan National Teaching Hospital.

@entity1 @entity704 @entity5 @entity189 @entity1349
BACKGROUND: @entity704 are @entity5 for which surgical resection is the first treatment of choice. The role of adjuvant treatment after surgery is unknown because of limited available data. The present study evaluated the efficacy of post-surgery adjuvant chemotherapy or radiotherapy in @entity1 with @entity704 . METHODS: To evaluate the role of adjuvant therapy in @entity1 with @entity704 , we retrospectively reviewed the records of @entity1 with @entity704 who were diagnosed and treated between 2004 and 2014. RESULTS: Among 78 @entity1 with @entity704 , 30 @entity1 received surgical resection. Progression-free survival (PFS) and @entity1349 ( @entity1349 ) were significantly longer among these @entity1 than among @entity1 who received other treatments (PFS: 88.4 months vs 9.1 months, p<0.001; @entity1349 : 134.9 months vs 60.9 months; p = 0.003). @entity1 with @entity5 who received surgery had a longer @entity1349 than @entity1 who did not receive surgery (70.1 months vs 23.9 months; p = 0.017, n = 11). Among 47 @entity1 with stage IV @entity189 , 12 @entity1 who received an extended thymothymectomy had a longer PFS than 35 @entity1 who did not receive surgery (18.9 months vs 8.7 months; p = 0.029). Among 30 @entity1 (with stage I- IV @entity189 ) who received primary lesion surgery, 19 @entity1 received an R0 resection and 9 @entity1 of the 19 @entity1 received adjuvant radiotherapy. These @entity1 had longer PFS (50.3 months) than 2 @entity1 who received adjuvant chemotherapy (5.9 months) or 4 @entity1 who received concurrent chemoradiotherapy (7.5 months) after surgery (p = 0.003). CONCLUSIONS: Surgical resection should be considered for @entity1 with @entity704 , even for @entity1 with locally advanced or stage IV @entity189 . Adjuvant radiotherapy resulted in a better PFS after R0 resection.
