Information processing components of the auditory event related potential are reduced by XXXX .

@entity1 @entity2072 @entity19689 @entity3493
The effects of @entity2072 on a @entity1 electroencephalographic event related potential (ERP) were measured. Forty-eight subjects received one of three IV doses (0.2, 0.4, or 0.6 mg/kg) and placebo. Thirty-three subjects received one of three oral doses (2, 3, or 4 mg/kg). All IV and oral doses reduced amplitude of the auditory ERP @entity19689 and @entity3493 components during the oddball task. @entity19689 latency decreased. N100 amplitude was reduced only after IV administration. The changes in ERPs occurred during the period of peak cardiovascular and subjective effects. The amplitude reduction in ERP components occurring before the @entity3493 component is consistent with decrements in attention, specifically selective attention. The @entity3493 amplitude reduction after @entity2072 suggests a disruption of stimulus evaluation resources. The findings are inconsistent with the notion that stimulants affect only response selection and execution. The degree to which stimulants alter cognitive processes prior to response selection may depend on the magnitude of the cardiovascular, subjective, and probably other noncognitive effects.
