Vasodilatation of muscle microvessels induced by somatic afferent stimulation is mediated by calcitonin gene-related peptide release in the XXXX .

@entity8425 @entity35 @entity717 @entity121 @entity4655
In anesthesized @entity35 , the effects of @entity8425 ( @entity8425 ) to the saphenous nerve on the microcirculation of the gracilis muscle were assessed through the measurement of two different hemodynamic parameters: (a). the @entity121 ( @entity121 ) using a laser Doppler flowmeter; and (b). the changes in diameter of the muscle arterioles observed directly using an intravital microscope system. Ipsilateral @entity8425 (5 V, 20 Hz, for 30 s) produced increases in @entity121 and mean arterial pressure (47+/-10% and 18+/-5%) over the baseline, while no significant changes in @entity121 were observed in the contralateral muscle. Neither selective nor simultaneous alpha- and beta-adrenergic blockade altered the increases in @entity121 induced by @entity717 . The arteriolar diameter was found to increase by 38.9+/-5% following @entity717 . This response in diameter was abolished after the topical application of a calcitonin gene-related peptide receptor antagonist ( @entity4655 (8-37)). Contralateral @entity8425 produced a decrease in arteriolar diameter by 26+/-14%. Thus, ipsilateral nerve @entity8425 produced vasodilative responses in the muscle accompanied by increases in @entity121 independently of the sympathetic activity. Furthermore, @entity4655 was found directly involved in the reflex neural regulation of the muscle microcirculation, which suggests the participation of an axon reflex mechanism.
