Dynamics of chemosensitivity and chromosomal instability in recurrent XXXX .

@entity1 @entity8634 @entity146 @entity5 @entity11770 @entity982 @entity2903 @entity463
@entity463 multiforme is characterised by invasive growth and frequent recurrence. Here, we have analysed chromosomal changes in comparison to @entity5 cell @entity146 and chemosensitivity of three cell lines established from a primary @entity5 and consecutive recurrences (BTL1 to BTL3) of a long-term surviving @entity463 @entity1 together with @entity982 -embedded materials of five further cases with recurrent disease. Following surgery, the BTL @entity1 progressed under irradiation/ @entity11770 but responded to @entity2903 after re-operation to @entity2903 . The primary @entity5 -derived BTL1 cells showed chromosomal imbalances typical of highly aggressive @entity463 . Interestingly, BTL2 cells established from the first recurrence developed under therapy showed signs of enhanced chromosomal instability. In contrast, BTL3 cells from the second recurrence resembled a @entity5 . Although BTL2 cells exhibited a highly aggressive phenotype, BTL3 cells were characterised by reduced proliferative and migratory potential. Despite persistent methylation of the @entity8634 -DNA methyltransferase promoter, BTL3 cells exhibited the highest @entity2903 sensitivity. A comparable situation was found in two out of five @entity463 @entity1 , both characterised by enhanced survival time, who also relapsed after surgery/chemotherapy with less aggressive recurrences. Taken together, our data suggest that pretreated @entity463 @entity1 may relapse with highly chemosensitive @entity5 confirming the feasibility of @entity2903 treatment even in case of repeated recurrence.
