Plaque morphologies and the clinical prognosis of XXXX caused by lesions with intact fibrous cap diagnosed by optical coherence tomography.

@entity1 @entity1187 @entity712 @entity583 @entity2681 @entity6391 @entity397 @entity299 @entity715
BACKGROUND: Pathological studies have suggested that @entity1187 ( @entity1187 ) may be caused by culprit lesions with intact fibrous cap (IFC), including @entity2681 . This study sought to evaluate the morphological features and clinical outcomes of @entity1 with @entity1187 caused by lesions with IFC. METHODS: A total of 318 @entity1 with @entity1187 who underwent optical coherence tomography (OCT) of a culprit lesion were investigated. The culprit lesions were categorized as follows: those with @entity397 (PR group), those with an IFC (IFC group), and those with a massive @entity715 precluding plaque visualization (MT group). Intravascular ultrasound (IVUS) was performed in 297 @entity1 . Clinical follow-up data were collected regarding adverse @entity299 , including death, @entity583 , revascularization, and @entity712 requiring hospitalization. RESULTS: Culprit lesions were categorized into 141 RPs, 131 IFCs, and 46 MTs. IFC group exhibited a smaller remodeling index and less frequently attenuated plaques on IVUS. Three hundred and seven @entity1 (96.5%) were followed for a median follow-up duration of 576days. Adverse @entity299 were observed in 93 @entity1 (30.3%). Kaplan-Meier analysis demonstrated a significantly lower event rate in IFC group compared with the @entity6391 and MT groups. Cox proportional hazard analysis demonstrated that an IFC and multivessel disease were independent predictors of adverse events [hazard ratio 0.57, 95% confidence interval (CI) 0.33-0.98, p=0.043 and hazard ratio 1.72, 95% CI 1.09-2.73, p=0.021]. CONCLUSIONS: Culprit lesions with IFC showed smaller remodeling indices by IVUS, and were associated with better long-term prognosis compared with those with @entity397 .
