Inflammation modulates XXXX in an animal model of @entity15 .

@entity6504 @entity32 @entity6220 @entity308 @entity3659 @entity19 @entity5 @entity51 @entity1316 @entity148 @entity1651 @entity1063 @entity15 @entity528
@entity15 ( @entity15 ) is a chronic @entity6220 (CNS) characterized by @entity32 , but also degenerative changes. Besides @entity51 , the rate of @entity1316 such as @entity308 and @entity148 is at least six fold increased. Many aspects of @entity15 can be mimicked in the animal model of @entity6504 experimental autoimmune @entity1651 (MOG-EAE). Here we investigate behavioral changes in C57BL/6 @entity19 suffering from mild MOG-EAE. In the later phase of the disease, @entity19 were subjected to behavioral tests including the light-dark-box (LD Box), the acoustic startle response (SR) with a pre-pulse inhibition protocol as well as the learned helplessness (LH) paradigm. Behavioral data were correlated with the motor performance in an open field and rotarod test (RR). In the RR and open field, there was no significant difference in the motor performance between controls and @entity19 suffering from mild MOG-EAE. Yet EAE @entity19 displayed an increased @entity148 -like behavior with a 23% reduction of the time spent in the bright compartment of the LD Box as well as an increased SR. In the LH paradigm, @entity19 suffering from MOG-EAE were twice as much prone to depressive-like behavior. These changes correlate with an increase of hippocampal tissue @entity5 necrosis factor alpha levels and @entity528 in the hippocampus. Modulation of monoaminergic transmission by chronic application of the antidepressant @entity3659 resulted in a decreased startle reaction and increased hippocampal @entity1063 levels. These data imply that @entity32 in the CNS may impact on emotional responses in rodent models of @entity148 .
