Influence of blood lipids on XXXX test results.

@entity2067 @entity1003 @entity3459 @entity10931 @entity412 @entity5582 @entity165
BACKGROUND: High levels of blood lipids have been associated with high levels of coagulation factors. We investigated whether blood lipids influence the results of @entity3459 tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA). METHODS: PT, aPTT, and TGA, along with procoagulant and anticoagulant factors, were measured in 488 normal individuals. @entity2067 status was assessed with prothrombin-induced by @entity2067 absence-II (PIVKA-II). RESULTS: The procoagulant factors II, VII, IX, X, and XI and anticoagulant factors protein C and protein S showed significant correlations with @entity412 , and the procoagulant factors II, V, VII, IX, X, XI, and XII and anticoagulant factors @entity5582 and protein C correlated with total @entity165 . There were no correlations of blood lipid levels with PIVKA-II levels. Subjects with high @entity412 levels (>= 200 mg/dL) showed shorter PT values than those with lower @entity412 levels. However, aPTT value was not changed in terms of blood lipid levels. In both 1 and 5 pM tissue factor-induced @entity10931 , subjects in the high- @entity412 or high- @entity165 groups (>= 240 mg/dL) had high levels of lag time, time-to-peak, and endogenous thrombin potential. Total @entity165 was a significant determinant of PT and TGA values. CONCLUSION: High blood lipids were related with @entity1003 activity in a normal population. Our findings are expected to help interpret the @entity3459 test results in individuals with high lipid levels.
