Cellular energetics in @entity548 : restoring XXXX to the cells.

@entity52379 @entity548 @entity1160 @entity3624 @entity26 @entity3652 @entity4763 @entity880 @entity35 @entity5161 @entity857 @entity855 @entity2383
BACKGROUND: This is a review of studies with two agents, @entity1160 and @entity52379 , which have been found to enhance recovery of cellular @entity855 ( @entity855 ) and @entity857 after @entity548 . METHODS: The studies used a sublethal (30 minutes) reservoir shock model in 300- to 350-g, male, @entity35 , using either @entity3652 - @entity4763 or @entity5161 anesthesia. @entity1160 was given as a 3% (21 mmol/L) solution in Ringer's @entity880 (630 mg/kg). @entity52379 was given as a 500 nmol/L solution in Ringer's @entity880 (2 mg/kg). RESULTS: Both @entity1160 and @entity52379 caused recovery of @entity855 to baseline levels (9.0 micromol/g) within 60 to 120 minutes after resuscitation. @entity3624 levels returned more rapidly to baseline (0.1 micromol/g). Both agents prevented the elevation in apoptosis seen in controls at 24 and 48 hours. CONCLUSION: @entity1160 is a metabolic substrate and a precursor of @entity855 synthesis. @entity52379 enhances @entity26 diffusivity in plasma. Both agents restore cellular energy stores to normal after @entity548 and produce a marked diminution in the extent of apoptosis postshock. Their mechanism of action probably involves prevention of @entity2383 .
