Brain activation during self- and other-reflection in @entity162 with a history of psychosis: Comparison to XXXX .

@entity1 @entity162 @entity161 @entity2414
OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in @entity1 with @entity162 ( @entity162 ). In addition, we examined whether potential abnormal brain activation in @entity162 @entity1 could distinguish @entity162 from @entity1 with @entity161 ( @entity161 ). METHODS: During functional magnetic resonance imaging (fMRI), 17 @entity162 @entity1 , 17 @entity161 @entity1 and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control. RESULTS: @entity162 @entity1 showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p  =  0.028 FWE corrected on cluster-level within the regions of interest). In @entity161 @entity1 , the level of activation in this area was in between @entity162 @entity1 and HCs, with no significant differences between @entity1 with @entity161 and @entity162 . There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in @entity161 @entity1 , but not in @entity162 @entity1 . CONCLUSIONS: @entity162 @entity1 showed less activation in the PCC/precuneus during other-reflection. This may support an account of @entity2414 (evaluation of past and current other-related information) in @entity162 @entity1 . Correlation differences of the PCC/precuneus activation with the cognitive insight in @entity1 with @entity162 and @entity161 might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers.
