Characteristic features of granular deposit formation in granular XXXX .

@entity1 @entity267 @entity3985 @entity2687 @entity14668 @entity62
PURPOSE: To describe the characteristic features of @entity62 associated with granular @entity3985 (GCD2). METHODS: Five @entity1 with GCD2 associated with the @entity14668 mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The @entity2687 of all @entity1 were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete @entity2687 using Image J software. A Fourier-domain optical coherence tomography with @entity267 anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. RESULTS: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all @entity1 . The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the @entity2687 , surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous @entity1 and natural progression in a heterozygote @entity1 . They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. CONCLUSIONS: In GCD2, discrete @entity62 were surrounded by rather lucid areas and fine granular haze. These findings suggest that @entity62 may be formed by aggregation of surrounding fine granules.
