@entity5705 , genetically elevated high-density lipoprotein, and risk of XXXX .

@entity1479 @entity1 @entity63 @entity71963 @entity5705 @entity71965 @entity71962 @entity71964 @entity741 @entity71961 @entity65 @entity165 @entity44838
CONTEXT: @entity5705 influences metabolism of high-density lipoprotein (HDL), a risk factor for @entity65 ( @entity1479 : @entity741 and @entity63 ). OBJECTIVE: We tested the hypothesis that genetic variation in the @entity5705 genetic variants @entity71961 , @entity71962 , @entity71963 , @entity71964 , @entity71965 , and @entity44838 influence levels of lipids, lipoproteins, and apolipoproteins and risk of @entity1479 . DESIGN: For the cross-sectional study, we genotyped 9003 individuals from the Copenhagen City Heart Study; hereof were 8971 individuals included in the prospective study, 1747 of whom had incident @entity1479 during 28 yr of follow-up. For the case-control studies, 2110 @entity741 @entity1 vs. 4899 controls and 769 @entity63 @entity1 vs. 2836 controls, respectively, were genotyped. Follow-up was 100% complete. RESULTS: HDL @entity165 was higher by 0.21 mmol/liter in @entity71963 heterozygotes, by 0.06 mmol/liter in -480c>t heterozygotes, and by 0.13 mmol/liter in -480c>t homozygotes, as compared with noncarriers. These HDL increases theoretically predicted hazard ratios for @entity1479 of 0.87 [95% confidence interval (CI) 0.84-0.90], 0.96 (95% CI 0.95-0.97), and 0.91 (95% CI 0.89-0.94), respectively; this calculation assumes that genetically elevated HDL levels confer decreased risk similar to common HDL elevations. In contrast, when all cases and controls were combined, the observed odds ratios for @entity1479 for these three genetic variants vs. noncarriers were 1.19 (0.76-1.88), 1.04 (0.96-1.13), and 1.08 (0.89-1.30), respectively. Hazard/odds ratios for @entity1479 in carriers vs. noncarriers of the four remaining @entity5705 genetic variants did not differ consistently from 1.0. CONCLUSION: @entity5705 genetic variants with elevated levels of HDL @entity165 did not associate with risk of @entity1479 .
