Correlation of XXXX levels in serum and synovial fluid with disease severity of @entity626 .

@entity1 @entity626 @entity1841 @entity571
Background This study aimed to investigate the @entity1841 ( @entity1841 ) levels in serum and synovial fluid (SF) of @entity1 with primary @entity626 ( @entity571 ) and to exam its correlation with radiographic and symptomatic severity of the disease. Material and Methods A total of 37 knee @entity571 @entity1 and 20 healthy controls were enrolled in this study. Knee @entity571 radiographic grading was performed according to the Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed in anteroposterior knee radiography. Symptomatic severity of the disease was evaluated according to the Western Ontario @entity571 Index (WOMAC) scores. @entity1841 levels in serum and SF were determined using enzyme-linked immunosorbent assay. Results Serum @entity1841 level in @entity1 with knee @entity571 was higher than that in healthy controls. Knee @entity571 @entity1 with KL grade 4 showed significantly elevated @entity1841 levels in the serum and SF compared with those with KL grade 2 and 3. Knee @entity571 @entity1 with KL grade 3 had significant higher SF levels of @entity1841 than those with KL grade 2. @entity1841 levels in the serum and SF of knee @entity571 @entity1 were both positively correlated with KL grades and WOMAC scores. Conclusions @entity1841 levels in serum and SF were closely related to the radiographic and symptomatic severity of knee @entity571 and may serve as an alternative biochemical parameter to determine disease severity of primary knee @entity571 .
