High Dose Rate Brachytherapy in Two 9 Gy Fractions in the Treatment of Locally Advanced XXXX - a South Indian Institutional Experience.

@entity1 @entity137 @entity5 @entity4617 @entity1168
BACKGROUND: Although 3D image based brachytherapy is currently the standard of treatment in @entity5 , most of the centres in developing countries still practice orthogonal @entity4617 due to financial constraints. The quest for optimum dose and fractionation schedule in @entity1168 ( @entity1168 ) @entity4617 ( @entity4617 ) is still ongoing. While the American Brachytherapy Society recommends four to eight fractions of each less than 7.5 Gy, there are some studies demonstrating similar efficacy and comparable @entity137 with higher doses per fraction. OBJECTIVE: To assess the treatment efficacy and late complications of @entity1168 @entity4617 with 9 Gy per fraction in two fractions. MATERIALS AND METHODS: This is a prospective institutional study in Southern India carried on from 1st June 2012 to 31st July 2014. In this period, 76 @entity1 of @entity5 satisfying our inclusion criteria were treated with concurrent chemo-radiation following @entity4617 with 9 Gy per fraction in two fractions, five to seven days apart. RESULTS: The median follow-up period in the study was 24 months (range 10.6 - 31.2 months). The 2 year actuarial local control rate, disease-free survival and overall survival were 88.1%, 84.2% and 81.8% respectively. Although 38.2% @entity1 suffered from late @entity137 , only 3 @entity1 had grade III late @entity137 . CONCLUSIONS: In our experience, @entity1168 brachytherapy with 9 Gy per fraction in two fractions is an effective dose fractionation for the treatment of @entity5 with acceptable @entity137 .
