Evaluation of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and red blood cell distribution width-platelet ratio as early predictor of acute XXXX in pregnancy.

@entity1 @entity32 @entity788 @entity413 @entity1851
OBJECTIVE: Acute @entity788 (AP) is a state of @entity32 . It has been widely known that neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR) reflect systemic @entity32 . The aim of this study is to investigate whether these inflammatory markers could be used as reliable markers in early prediction of AP in pregnancy and if there is a relationship between disease severity and these markers. METHODS: The study group consisted of 14 @entity1 , who developed AP in ongoing pregnancy, and the control group consisted of 30 healthy pregnant @entity1 . NLR, PLR and RPR were calculated for both the groups. RESULTS: NLR was significantly elevated in the AP group when compared with the controls (p   =   0.00), but there was no statistically significant difference in terms of PLR and RPR (p   >   0.05). ROC curve analysis results for NLR showed that there was a significant prediction power of NLR for AP (R(2)   =   0.842; p   <   0.001). For NLR parameter, if cut-off value is chosen to be 4.1030, then sensitivity is 71.4% and specificity is 100.0%. There was statistically significant and positive correlation between @entity1851 ( @entity1851 ) and @entity413 with NLR (p   =   0.001, p   =   0.043). It was seen that Ranson was close to be significant (p   =   0.051). CONCLUSION: NLR might be used as an early marker of AP and may have a role in prediction of disease severity.
