Decompressive Craniectomy increases Brain Lesion Volume and exacerbates Functional Impairment in @entity6075 in XXXX .

@entity1 @entity2657 @entity548 @entity19 @entity4 @entity16 @entity542 @entity6075 @entity2981 @entity130 @entity2383
UNASSIGNED: Decompressive craniectomy has been widely used in head @entity130 @entity1 . The randomized clinical trial on an early decompression (DECRA) demonstrated that craniectomy did not improve the neurological outcome, in contrast to previous animal experiments. The goal of our study was to analyze the effect of decompressive craniectomy in a @entity19 model of @entity542 . Male @entity19 were assigned into the following groups: sham, decompressive craniectomy, @entity6075 ( @entity6075 ) and @entity6075 followed by craniectomy. At 24h posttrauma animals were subjected to Neurological Severity Score test (NSS) and Beam Balance Score test (BBS). At the same time point magnetic resonance imaging was performed and volume of @entity4 and @entity2981 was assessed, followed by histopathological analysis. According to NSS, animals subjected to both @entity130 and craniectomy presented the most severe @entity16 . Also balancing time was reduced in this group compared to sham animals. Both @entity4 and @entity2981 volume was increased in @entity130 and craniectomy group compared to sham animals. Histopathological analysis showed that all animals subjected to @entity130 presented substantial neuronal loss. In animals treated with craniectomy after @entity130 , a massive increase of @entity4 with @entity548 was documented. Decompressive craniectomy applied after @entity6075 in @entity19 leads to additional @entity2383 . The surgical decompression via craniectomy promotes @entity2657 formation and contusional blossoming in our model. This additive effect of combined mechanical and surgical @entity130 may explain the results of DECRA trial and should be further explored in experiments.
