[Involvement of XXXX in upper aero-digestive tracts @entity5 ].

@entity1 @entity2953 @entity986 @entity5 @entity1083 @entity996 @entity2622 @entity189 @entity876 @entity1800 @entity1082 @entity694 @entity213
@entity1082 ) is one of the most common causes of @entity2953 in the world. France and Belgium present one of the highest incidence of @entity213 ( @entity213 ) worldwide. Besides, considering only the male population, HNSCCs represent the fourth most frequent @entity5 after prostate, lung and @entity694 . Although the causal link between high-risk HPVs and @entity2622 is well established, the implication of this @entity1800 in @entity213 remains debatable. Here, we discuss current knowledge concerning the HPV implication in HNSCCs. Based on our literature review, 20 to 25% of HNSCCs could be associated with oncogenic HPVs, in particular HPV type 16. The oropharynx--more precisely the tonsil--is the head and neck location presenting the highest incidence of @entity1083 . Moreover, a clear @entity189 incidence has been described. As observed in cervical @entity189 , HPV positive HNSCCs are sexually transmitted and characterized by alterations of @entity876 and @entity996 signalling pathways. Several studies have shown that HPV positive subgroup presented better prognosis particularly if these @entity1 overexpressed @entity986 . New studies regarding HPV status in HNSCCs are warranted to provide a rationale for large scale HPV vaccination in young male populations.
