XXXX : clinical significance and implications in practice.

@entity1 @entity8958 @entity5 @entity1373 @entity4383 @entity259 @entity1374
Incidental @entity1373 ( @entity1373 ) following thyroidectomy for other indications may rarely be encountered, which may raise concerns about its clinical significance and proper management. @entity1373 can be classified as physiological (reactive) or neoplastic. Reactive @entity1373 has no malignant potential and can be observed in association with many other @entity1374 (including differentiated @entity259 ); in contrast, @entity5 should be considered as a preneoplastic stage in the spectrum of C cell disease, ultimately leading to the development of @entity259 ( @entity259 ). Neoplastic @entity1373 is commonly observed in @entity1 with germ-line mutations in the @entity8958 oncogene (commonly in families with a history of hereditary @entity259 , i.e. familial @entity259 or multiple endocrine neoplasia type 2 (MEN2)). @entity1373 should be considered in @entity1 with hypercalcitoninemia without @entity4383 . Total thyroidectomy, which is commonly performed for the majority of @entity1374 , is an adequate treatment and achieves cure, even in @entity1 with @entity5 . There is no role for cervical lymph node dissection in @entity1 with pure @entity1373 . In conclusion, reactive @entity1373 has no malignant potential, in contrast to @entity5 . Total thyroidectomy achieves cure of @entity1 with @entity1373 .    2015 S. Karger GmbH, Freiburg.
