Endothelium-dependent vascular responses in normotensive and XXXX Dahl @entity35 .

@entity101 @entity1219 @entity1854 @entity1372 @entity1424 @entity7102 @entity750 @entity35 @entity1063 @entity934
Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl @entity35 (DR). The @entity35 were fed a low @entity1372 (0.1% @entity1219 ) or high @entity1372 (8% @entity1219 ) diet for 8 weeks. Blood pressure in DS fed a high @entity1372 diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. @entity934 , @entity1424 , and @entity7102 induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high @entity1372 diet. The relaxations in response to @entity1854 were only slightly, but significantly, depressed in DS fed a high @entity1372 diet. Removal of the endothelium greatly enhanced the response to @entity750 and @entity1063 . In rings with, but not without, endothelium taken from @entity35 fed a high @entity1372 diet, the tension developed in response to @entity750 and @entity1063 was significantly greater than that in animals fed a low @entity1372 diet. These experiments indicate that endothelium-dependent relaxations to @entity934 , @entity1424 , and @entity7102 are depressed in @entity101 Dahl @entity35 ; this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high @entity1372 diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.
