Menopausal hot flashes and XXXX .

@entity1 @entity62 @entity65
OBJECTIVE: Hot flashes are classic symptoms of menopause. Emerging data link hot flashes to @entity65 ( @entity65 ) risk, yet whether hot flashes are related to brain health is poorly understood. We examined the relationship between hot flashes (measured via physiologic monitor and self-report) and @entity62 ( @entity62 ) among midlife @entity1 . METHODS: Twenty midlife @entity1 (aged 40-60 y) without clinical @entity65 , with an intact uterus and ovaries, and not taking hormone therapy were recruited. @entity1 underwent 24 hours of ambulatory physiologic and diary hot flash monitoring to quantify hot flashes; magnetic resonance imaging to assess @entity62 burden; 72 hours of actigraphy to quantify sleep; and a blood draw, questionnaires, and physical measures to quantify demographics and @entity65 risk factors. Tests of a priori hypotheses regarding relationships between physiologically monitored and self-reported wake and sleep hot flashes and @entity62 were conducted in linear regression models. RESULTS: More physiologically monitored hot flashes during sleep were associated with greater @entity62 , controlling for age, race, and body mass index (b [SE] = 0.0002 [0.0001], P = 0.03]. Findings persisted after controlling for sleep characteristics and additional @entity65 risk factors. No relationships were observed for self-reported hot flashes. CONCLUSIONS: More physiologically monitored hot flashes during sleep are associated with greater @entity62 burden among midlife @entity1 without clinical @entity65 . Results suggest that the relationship between hot flashes and @entity65 risk observed in the periphery may extend to the brain. Future work should consider the unique role of sleep hot flashes in brain health.
