Is It Possible to Differentiate XXXX and @entity1468 by means of New and Old Biomarkers? A Prospective Study.

@entity1 @entity644 @entity7309 @entity101 @entity3152 @entity740 @entity1468
UNASSIGNED: Objective. @entity740 ( @entity740 ) and @entity1468 ( @entity1468 ) may both present with @entity101 and @entity644 in pregnancy. Our objective is to test the possibility of distinguishing @entity740 from @entity1468 by means of uteroplacental flows and maternal circulating sFlt-1/ @entity7309 ratio. Design. Prospective analysis. Population. Seventy-six @entity1 (35 @entity740 , 24 @entity1468 , and 17 other @entity101 ), with at least one sFlt-1/ @entity7309 and Doppler evaluation after the 20th gestational week. Methods. Maternal sFlt-1- @entity7309 were determined by immunoassays. Abnormal uterine artery Doppler was defined as resistance index >=  0.58. Umbilical Doppler was defined with gestational-age-adjusted Pulsatility Index. Clinical diagnosis was considered as reference. Performance of Doppler study was assessed by sensitivity analysis; sFlt-1/ @entity7309 cut-off values were determined by ROC curves. Results. The lowest sFlt-1/ @entity7309 ratio (8.29) was detected in @entity740 , the highest in @entity1468 (317.32) (P < 0.001). Uteroplacental flows were mostly preserved in @entity740 @entity1 in contrast to @entity1468 (P < 0.001). ROC analysis suggested two cut-points: sFlt-1/ @entity7309 >=  32.81 (sensitivity 82.93%; specificity 91.43%) and sFlt-1/ @entity7309 >=  78.75 (sensitivity 62.89%, specificity 97.14%). Specificity reached 100% at sFlt-1/ @entity7309 >=  142.21 (sensitivity: 48.8%). Early- @entity3152 was associated with higher sFlt-1/ @entity7309 ratio and abnormal uteroplacental flows relative to late-preterm and term deliveries. Conclusions. sFlt-1/ @entity7309 ratio and uteroplacental flows significantly correlated with @entity1468 or @entity740 and @entity3152 .
