Evaluation of effects of XXXX in reducing intraoperative anaesthetic requirements.

@entity1 @entity1760 @entity3369 @entity2400 @entity1875 @entity1937
BACKGROUND: The present randomized, placebo-controlled, double-blind study was designed to assess the effect of peroperatively administered i.v. @entity2400 on anaesthetic and analgesic requirements during total i.v. anaesthesia. METHODS: Eighty-one @entity1 (36 @entity1 , 45 @entity1 ) undergoing elective spinal surgery were included in one of two parallel groups. The @entity1760 group received @entity2400 30 mg kg(-1) as a bolus before induction of anaesthesia and 10 mg kg(-1) h(-1) by continuous i.v. infusion during the operation period. The same volume of isotonic solution was administered to the control group. Anaesthesia was maintained with @entity1875 (administered according to the bispectral index) and @entity1937 (adjusted according to heart rate and arterial blood pressure) infusions. RESULTS: A significant reduction in hourly @entity1875 consumption was observed with @entity1760 administration. For example, the mean infusion rate of @entity1875 in the second hour of the operation was 7.09 mg kg(-1) h(-1) in the control group vs 4.35 mg kg(-1) h(-1) in the @entity1760 group (P<0.001). The @entity1760 group required significantly less @entity1937 (P<0.001) and @entity3369 (P<0.001). No side-effects were observed with @entity1760 administration. CONCLUSION: The administration of @entity1760 led to a significant reduction in the requirements for anaesthetic drugs during total i.v. anaesthesia with @entity1875 , @entity1937 and @entity3369 .
