Intraoperative XXXX Administration Does Not Reduce Postoperative @entity955 After Cardiac Surgery.

@entity1 @entity4612 @entity63 @entity1272 @entity955 @entity1760
BACKGROUND: @entity1272 has been associated with an increased risk of @entity955 ( @entity955 ). Although previous studies have suggested a beneficial effect of @entity1760 ( @entity4612 ) therapy, almost all of these are limited by small sample size and relatively low @entity4612 dose. We hypothesized that high-dose @entity4612 decreases the occurrence of new-onset @entity955 , and we tested this hypothesis by using data from a prospective trial that assessed the effect of @entity4612 on cognitive outcomes in @entity1 undergoing cardiac surgery. METHODS: A total of 389 @entity1 undergoing cardiac surgery were enrolled in this double-blind, placebo-controlled trial. Subjects were randomized to receive @entity4612 as a 50- @entity4612 /kg bolus immediately after induction of anesthesia followed by another 50 @entity4612 /kg as an infusion given over 3 hours (total dose, 100 @entity4612 /kg) or placebo. We tested the effect of @entity4612 therapy on @entity955 with logistic regression, adjusting for the risk of @entity955 ( @entity955 ) by using the Multicenter Study of Perioperative @entity63 risk index for @entity955 after Cardiac Surgery. RESULTS: Among the 363 @entity1 analyzed, after we excluded @entity1 with chronic or acute preoperative @entity955 (placebo: n = 177; @entity4612 : n = 186), the incidence of new-onset @entity955 was 42.5% (95% confidence interval [CI], 35%-50%) in the @entity4612 group compared with 37.9% (95% CI, 31%-45%) in the placebo group (P = 0.40). The 95% CI for this absolute risk difference of 4.6% is -5.5% to 14.7%. The time to onset of @entity955 also was identical between the groups, and no significant effect of @entity4612 was found in logistic regression analysis after we adjusted for @entity955 risk (odds ratio, 1.09; 95% CI, 0.69-1.72; P = 0.73). CONCLUSIONS: High-dose intraoperative @entity4612 therapy did not decrease the incidence of new-onset @entity955 after cardiac surgery.
