The effect of an intravenous infusion of hypertonic saline on renal mechanisms and on electrolyte changes in XXXX .

@entity742 @entity2865 @entity1372 @entity972 @entity2827
1. The ability of the @entity742 to tolerate excess @entity2827 has been investigated by subjecting @entity742 to an intravenous infusion of a 10% solution of @entity2827 .2. Inulin and diodrast clearances failed to show any consistent changes in glomerular filtration rate but the effective renal plasma flow was slightly more. Plasma levels of @entity1372 and @entity2865 increased by 20-25% and @entity972 decreased by 30%. Urinary levels for @entity1372 and @entity2865 showed a corresponding increase and @entity972 excretion was reduced.3. The rates of re-absorption of @entity1372 and @entity2865 from the renal tubules were found to be proportional to their rates of filtration at the glomerulus, but this ratio was reduced after the hypertonic saline infusion. No such correlation could be established for @entity972 .4. Osmolar clearances indicated that continued re-absorption of osmotically free water from the kidney tubular fluid occurred during and after the hypertonic saline. Excretion of urine, hyperosmotic to plasma, was thus maintained and water conservation supported.5. Possible renal mechanisms associated with these effects are discussed.
