Assessing joint involvement in @entity447 by clinical rheumatologic scores. A pilot study on similarities with subjects with XXXX .

@entity1 @entity227 @entity571 @entity548 @entity447 @entity66 @entity73 @entity3331 @entity5144 @entity14361 @entity1691 @entity158 @entity2720 @entity309
Because of joint @entity548 , severe @entity447 subjects often have limitations in their daily activities. Current orthopaedic scores (OJS) in @entity447 miss mild @entity73 and only pick up severe alterations. Twelve young severe haemophiliacs (20.25        1.9  years of age), were evaluated for OJS as well as for indices employed in @entity309 [28-joint Disease Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), @entity227 ( @entity227 )], @entity1691 [Bath @entity1691 Activity Index (BASDAI), HAQ, @entity227 ] and @entity571 [ @entity3331 and @entity571 Outcome Score (KOOS), @entity227 ]. Twenty-four matched apparently healthy subjects and 29 subjects with @entity5144 ( @entity5144 ) with @entity14361 (one to three swollen joints) served as controls. In addition to the impairment of @entity2720 (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis), HAQ (mean 0.71        0.95) and @entity227 (3.12        2.36) documented a quality of life and a perception of @entity158 in haemophiliacs similar to that of @entity5144 subjects (p   =   0.061 and p   =   0.063, respectively). Their Ritchie index did not differ from that of subjects with @entity5144 (5.75        8.1 vs 7.73        9.22; p   =   0.408), nor did the BASDAI score with respect to @entity5144 @entity1 (p   =   0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function @entity73 ); 3 of 12 (25%) showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly correlated with @entity227 and HAQ in @entity447 subjects. A rheumatologic assessment may help identify early @entity66 and subclinical @entity66 not usually studied (not target joint) in haemophiliacs. These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting.
