Prevalence of reduced XXXX in patients with anti-neutrophil cytoplasmic antibody associated @entity1333 and the role of immunosuppressive therapy: a cross-sectional study.

@entity1 @entity174 @entity1333 @entity604 @entity170 @entity786 @entity79 @entity2331 @entity19417 @entity288
Anti-neutrophil cytoplasmic antibody (ANCA)-associated @entity1333 is a relapsing-remitting disease, which is treated with @entity288 (CS) in combination with @entity786 . One of the major side-effects of this treatment is @entity170 , which may result in the increased occurrence of @entity174 . In the present study we measured the prevalence of reduced @entity79 ( @entity79 ) in a cross-sectional cohort of @entity1 and correlated @entity79 findings with cumulative doses of CS and/or @entity786 . @entity79 was measured by dual-energy X-ray absorptiometry (DXA) of the lumbar spine, radius and proximal femur between January 1998 and December 1999. Cumulative doses of CS and @entity786 were calculated by chart review. Ninety-nine consecutive @entity1 (48 @entity1 , 51 @entity1 ) aged 55 +/- 16 years (mean +/- SD) were studied 50 months (median; range 0-400 months) after a diagnosis of @entity19417 had been made. Sixty-nine @entity1 were treated with 10.7 g (median cumulative dose; range 0.4-67.2 g) of CS, and 88 @entity1 were treated with 34.1 g (median cumulative dose; range 0.8-324.3 g) of @entity786 . Fifty-seven percent of the @entity1 had @entity2331 (T-score: -1 to -2.5 SD), and 21% had @entity170 (T-score: <-2.5 SD) at least at one site. Thirty-four of 37 (92%) postmenopausal @entity1 , 9 of 14 (64%) premenopausal @entity1 , and 34 of 48 (71%) @entity1 had either @entity2331 or @entity170 . The mean age- and sex-adjusted @entity79 (Z-score) of the proximal femur in @entity1 was found to be significantly lower than zero. Cumulative dose of CS therapy showed an inverse relation with Z-scores at the lumbar spine (p = 0.035) and proximal femur (p = 0.011). Cumulative dose of @entity786 was not correlated with Z-scores. @entity2331 and @entity170 are thus frequently observed in @entity1 with ANCA-associated vasculities. However, only in @entity1 is the mean Z-score significantly lower than zero. Cumulative dose of CS therapy is significantly associated with @entity604 at the spine and femur.
