In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of XXXX subjects.

@entity1169 @entity56392 @entity28 @entity3773 @entity653 @entity2161 @entity1063 @entity1068
The role of alpha(1)-adrenoceptors in lipid mobilization and blood flow was investigated in situ using microdialysis of subcutaneous adipose tissue in severely @entity28 subjects. The lipolysis rate was assessed by determination of interstitial @entity653 concentration. The alpha(1)-adrenoceptor agonist @entity56392 caused an increase in @entity653 level in adipose tissue that was similar to that observed with the physiologic alpha(1,2)- @entity2161 agonist @entity1063 , whereas the alpha(1)-adrenoceptor antagonist @entity3773 showed no effect on basal lipolysis rate. However, the enhanced @entity653 concentration due to @entity56392 and @entity1063 was suppressed in the presence of @entity3773 . The beta-adrenoceptor antagonist @entity1169 showed no effect on @entity56392 -stimulated @entity653 outflow. Blood flow was assessed using the @entity1068 escape technique. Perfusion with @entity56392 decreased blood flow, whereas @entity3773 enhanced blood flow significantly. Despite the increase in blood flow, the basal interstitial @entity653 concentration remained unchanged. Although @entity56392 at high concentrations could inhibit the @entity3773 -induced increase in blood flow, the @entity56392 -induced @entity653 output was not affected. These results demonstrate that alpha(1)-adrenoceptors are involved in regulation of lipolysis rate and microcirculation of adipose tissue. However, the observed changes in local blood flow were not related to @entity653 output.
