Predictive factors of @entity3935 after extended thymectomy for @entity1 with XXXX

@entity1 @entity3935 @entity1737 @entity86
OBJECTIVES: @entity86 ( @entity86 ) is one of the serious complications after extended thymectomy for @entity1 with @entity1737 ( @entity1737 ). This study aims to clarify the risk factors of @entity86 occurrence. METHODS: The clinical data of 55 @entity1737 @entity1 (25 male, 30 female; median age, 51 years) who underwent extended thymectomy at Kyoto University from 2000 to 2013 were retrospectively reviewed. Surgical outcomes and pre- and perioperative predictive factors of @entity86 were analysed. RESULTS: The preoperative @entity1737 Foundation of America stage was I, II, III and IV in 24, 22, 8 and 1 @entity1 , respectively. Ten @entity1 (18.2%) developed @entity86 ; 6 required prolonged intubation over 24 h and 4 required reventilatory support. All @entity1 were weaned after 5.6 (2-26) days of ventilator support, and were discharged. Univariate analysis revealed a correlation with a high preoperative anti-acetylcholine receptor antibody titre (P = 0.009), history of @entity3935 ( @entity3935 ) (P = 0.0004) and unstable @entity1737 after preoperative medical therapy (P = 0.003). Multivariate logistic regression analysis showed history of @entity3935 (odds ratio, 11.84; 95% confidential interval, 1.05-372; P = 0.045) and unstable @entity1737 (odds ratio, 29.45; 95% confidential interval, 2.00-1063; P = 0.013) independently predicted @entity86 . The surgical response rate was not significantly different between the two groups (66.7% with @entity86 , 85.4% without @entity86 ; P = 0.334). CONCLUSIONS: @entity86 occurred more frequently in unstable @entity1737 before surgery or in @entity1 with a history of @entity3935 . Adequate preoperative medical therapy and perioperative care should be provided to these @entity1 .
