MicroRNA  -29a inhibits cell migration and invasion by targeting Roundabout  1 in XXXX cells.

@entity5 @entity695 @entity25996 @entity0
UNASSIGNED: MicroRNAs (miRs) are a group of small non  -coding RNAs, which influence the development and progression of @entity5 by mediating the protein expression levels of @entity5 suppressors or oncogenes. @entity695 has been reported to be involved in the pathogenesis of @entity0 . However, its precise functions, and the mechanisms underlying these effects, remain to be elucidated. The present study demonstrated that @entity695 was markedly downregulated in @entity0 tissues and cell lines. The protein expression of Roundabout  1 ( @entity25996 ) was negatively regulated by @entity695 in MCF  -7 @entity0 cells. Luciferase reporter assays identified @entity25996 as a direct target of @entity695 in MCF  -7 cells. Additionally, upregulation of @entity695 inhibited MCF  -7 cell migration and invasion, which was attenuated by the restoration of the expression of @entity25996 . Finally, it was shown that the expression of @entity25996 mRNA and protein was increased in @entity0 tissues and cell lines. Therefore, it was hypothesized that @entity695 inhibits cell migration and invasion in @entity0 cells, at least in part, by directly targeting @entity25996 . In conclusion, the present study highlights the importance of @entity695 and @entity25996 in the progression of @entity0 .
