Pathology of difficult XXXX .

@entity1 @entity32 @entity66 @entity565 @entity288
Severe @entity565 is poorly understood clinically, physiologically and pathologically. Although milder forms of @entity565 are generally easily treated, more severe forms remain refractory to the best current medical care. Both genetic and environmental elements are likely to play an important role in the development of @entity66 . Physiologically, these @entity1 often have air-trapping, airway collapsibility and loss of elastic recoil. The pathology demonstrates a heterogeneity of findings and is based mainly on adult studies. Some @entity1 demonstrate continued eosinophilic @entity32 despite the use of high doses of @entity288 . At least one-third appear to have pathological changes inconsistent with classically described asthmatic pathology. Persistent @entity32 can lead to structural changes involving the airways and perhaps the parenchyma as well. Finally, @entity32 and structural changes appear to exist well into the lung periphery, out of reach of many inhaled medications. The importance of each of these factors in the development of @entity66 probably varies from @entity1 to @entity1 . Understanding the commonalities of the pathology of severe @entity565 should, however, lead to the development of improved therapies.
