"Proliferative keratin cyst," a lesion in the lungs of XXXX following chronic exposure to para-aramid fibrils.

@entity1 @entity5 @entity6578 @entity358 @entity45 @entity35 @entity2784 @entity3759 @entity1141
Cystic and keratinizing @entity2784 have been observed in @entity35 exposed chronically to a number of particulates. A variety of diagnostic terms have been applied to these @entity358 but no consensus exists as to their most proper morphological classification. In an attempt to obtain a consensus for cystic keratinizing @entity358 produced in @entity35 by Kevlar para-aramid fibrils and @entity3759 powder, a panel of medical and veterinary pathologists was invited to participate in a workshop addressing the morphology of the lesions and to reach a consensus on a suitable descriptive diagnostic term. All @entity1 agreed that the cystic keratinizing lesions were not malignant @entity5 . The majority was of the opinion that the lesions were not @entity5 . A minority (3/13) considered the lesions to be @entity5 . The panel considered that the most appropriate morphologic diagnosis for the lesions was "proliferative keratin cyst" ( @entity45 ). In addition, the panel agreed on the following descriptive text: "The lesions are cysts lined by a well-differentiated stratified squamous epithelium with a central keratin mass. Growth appears to have occurred by keratin accumulation and by peripheral extension of the metaplastic change into the adjacent alveolar spaces. The lesions are sharply demarcated except in those areas in which there has been extension of metaplasia into adjacent alveoli. The squamous epithelium has few @entity6578 and @entity1141 is absent."
