The Association between Maternal Reproductive Age and Progression of XXXX in Urban Students in Beijing.

@entity1 @entity1714 @entity2516
PURPOSE: To investigate the association between maternal reproductive age and their @entity1 ' @entity2516 in Chinese urban students. METHODS: The Beijing Myopia Progression Study was a three-year cohort investigation. Cycloplegic refraction of these students at both baseline and follow-up vision examinations, as well as non-cycloplegic refraction of their parents at baseline, were performed. Student's refractive change was defined as the cycloplegic spherical equivalent (SE) of the right eye at the final follow-up minus the cycloplegic SE of the right eye at baseline. RESULTS: At the final follow-up, 241 students (62.4%) were reexamined. 226 students (58.5%) with completed refractive data, as well as completed parental reproductive age data, were enrolled. The average paternal and maternal age increased from 29.4 years and 27.5 years in 1993-1994 to 32.6 years and 29.2 years in 2003-2004, respectively. In the multivariate analysis, students who were younger (b = 0.08 diopter/year/year, P<0.001), with more myopic refraction at baseline (b = 0.02 diopter/year/diopter, P = 0.01), and with older maternal reproductive age (b = -0.18 diopter/year/decade, P = 0.01), had more myopic refractive change. After stratifying the parental reproductive age into quartile groups, @entity1 with older maternal reproductive age (trend test: P = 0.04) had more myopic refractive change, after adjusting for the @entity1 's age, baseline refraction, maternal refraction, and near work time. However, no significant association between myopic refractive change and paternal reproductive age was found. CONCLUSIONS: In this cohort, @entity1 with older maternal reproductive age had more myopic refractive change. This new risk factor for @entity1714 progression may partially explain the faster myopic progression found in the Chinese population in recent decades.
