[Distribution and prognostic significance of @entity5 -infiltrating mast cells in XXXX ].

@entity1 @entity5 @entity189 @entity34705 @entity1349
OBJECTIVE: To investigate the infiltration and prognostic significance of @entity5 -infiltrating mast cells (TIMs) in @entity189 ( @entity189 ). METHODS: Immunohistochemistry for tryptase was performed on 154 @entity189 specimens. The median value of @entity34705 density was used as a cutoff point to separate the @entity1 cohort into two groups with either low or high @entity34705 infiltration. The associations between @entity34705 and clinicopathological factors were analyzed by Mann-Whitney U text. Survival curves were plotted according to the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Log-rank test and the Cox proportional hazard models, respectively. P<0.05 was considered statistically significant. All statistical analyses were conducted using SPSS 13.0. RESULTS: @entity34705 was mainly in the stroma of @entity189 and detected in all specimens. The median value of @entity34705 density (25.60/high power field) was used as a cutoff point to separate the @entity1 cohort into two groups with either low or high @entity34705 infiltration. The density of @entity34705 was positively correlated with N stage (Z=-2.193, P<0.05) and clinical stage (Z=-2.551, P<0.05). The 3-year @entity1349 ( @entity1349 ) and progression-free survival (PFS) of @entity1 were 64.4% and 55.7% in the high @entity34705 density group; 78.3% and 77.0% in the low @entity34705 density group. For survival evaluation, high density of @entity34705 was associated with worse @entity1349 and PFS (P<0.05). Multivariate Cox regression model analysis showed @entity34705 infiltration was an independent risk factor for both @entity1349 and PFS. CONCLUSIONS: The density of @entity34705 in @entity189 increased with @entity5 stage. High @entity34705 infiltration was associated with poor @entity1349 and progression-free survival.
