A phase II study of continuous concurrent thoracic radiotherapy in combination with XXXX , @entity7324 and @entity900 in unresectable @entity5 .

@entity1 @entity7324 @entity882 @entity5 @entity1138 @entity1149 @entity900 @entity1503 @entity1431
The split-course concurrent thoracic radiation therapy (TRT) and full-dose chemotherapy for unresectable @entity5 ( @entity1149 ) has produced promising results by comparison with the sequential approach. Instead of split-course radiation, we conducted a phase II study to investigate the feasibility of continuous concurrent TRT and chemotherapy. Twenty-two @entity1 with unresectable @entity1149 were enrolled onto a phase II study of continuous concurrent radiotherapy and chemotherapy. Treatment consisted of two courses of @entity900 (80 mg/m(2) on days 1 and 29), @entity7324 (3 mg/m(2) on days 1, 8, 29 and 36), and @entity1138 (8 mg/m(2) on days 1 and 29). TRT began on day 2 at a dose of 60 Gy (2 Gy per fraction and 5 fractions per week for a total of 30 fractions). Of 22 @entity1 assessable for response, none achieved a CR and 17 (77.3%) achieved a PR with an overall response rate of 77.3% (95% confidence interval, 54.6-92.2%). Grade 3 or 4 @entity1431 was observed in 5/13 (81.8%) @entity1 . Six @entity1 (27.3%) experienced > or = grade 3 @entity882 . @entity1503 was relatively mild. The overall median survival time was 19.0 months and the 1- and 2-year survival rates were 84.8 and 34.5%, respectively. It was possible to administer two courses of chemotherapy in 18 @entity1 (81.8%) as planned. Nineteen (86.4%) of the 22 @entity1 received the planned 60 Gy radiation. It seems to be difficult to administer the planned treatment without any interruption for the majority of @entity1 . However, in the selected @entity1 who completed the 60 Gy TRT, nearly half of the @entity1 completed TRT without interruption. This combination regimen is considered to be feasible on condition that the stopping rule of the treatment is followed. We recommend administering radiotherapy continuously as far as possible.
