@entity2806 changes the long term response to antidepressant drugs in XXXX .

@entity64 @entity308 @entity2806 @entity63 @entity19 @entity3755 @entity1188 @entity2645 @entity385
@entity308 is a frequent but often unrecognized and under treated complication of @entity64 that has scarcely been investigated in animal models particularly regarding treatment issues. Using the Forced Swim Test (FST) and testing spontaneous motor activity, we studied whether a transient focal @entity2806 modifies @entity19 behaviours and antidepressant drug effects. We first evaluated whether FST realized 2 days or 1 week after brain reperfusion may be routinely used in male Swiss @entity19 previously submitted to a 15, 30 or 60-min transient occlusion of the right middle cerebral artery. We then evaluated behavioural changes up to 5 weeks in @entity19 previously submitted to a 15-min @entity63 . Behaviours according to the administration of @entity2645 or @entity3755 at 1 and 5 weeks after a 15-min @entity63 were finally evaluated. Transient @entity63 was associated with a decrease in immobility in the FST performed 2 days after reperfusion while no changes were observed in 1 and 5 weeks post- @entity63 groups. Changes were related neither to @entity2806 duration nor to @entity1188 volume. At both 1 and 5 weeks after @entity2806 , a dramatic decrease in the antidepressant response to @entity2645 related to a decrease in climbing behaviour was observed while the effects of @entity3755 were improved through an increase in both climbing and swimming. Behaviours in the FST were unrelated to any spontaneous motor activity changes. Responses to anti-depressant drugs are strongly modified in @entity19 previously submitted to @entity2806 . Present results underline that not all antidepressant drugs are appropriate after @entity385 .
