Role of the hepatic artery in canalicular bile formation by the perfused XXXX liver. A multiple indicator dilution study.

@entity7362 @entity29677 @entity969 @entity35 @entity3645
The role of the hepatic artery in tracer water exchange and regulation of permeation of small solutes during canalicular bile formation was studied in the @entity35 using a system that permitted perfusion of both hepatic artery and portal vein. Hepatic vein and biliary multiple indicator dilution curves were obtained after injection of indicators into either vessel. The main difference in hepatic venous dilution curves was a 3.1-fold longer t0 (time spent in nonexchanging vessels) and a 5% larger equivalent water space after injection into the hepatic artery. Biliary tracer recovery of water was markedly higher after arterial injection than after portal vein injection. Both @entity7362 and @entity29677 stimulated bile flow and increased biliary tracer recovery after injection into either vessel. The biliary recovery of @entity969 relative to that of water, which is a measure of biliary @entity969 permeation, was much lower when given into the hepatic artery than when given into the portal vein. During @entity7362 infusion, it decreased by 33% in the hepatic artery but increased 36% in the portal vein. @entity29677 , by contrast, did not affect permeation of @entity969 given into the portal vein. Our studies demonstrate marked exchange of tracer water in the biliary epithelium. @entity7362 , but not @entity29677 , increases permeation of @entity969 into bile in the portal vein bed while both @entity3645 decrease it in the arterial bed.
