Presence of neurophysins in the @entity1 pituitary corticotrophs, @entity652 , and growth hormone-producing XXXX detected by immunohistochemical study.

@entity398 @entity1 @entity4545 @entity5 @entity977 @entity652 @entity71035
Neurophysins have been recognized as the carrier proteins of vasopressin and @entity398 . The distribution of neurophysins is immunohistochemically confirmed in the hypothalamus, median eminence, and posterior lobe of the pituitary gland. The authors detected neurophysins in the @entity1 corticotrophs and @entity977 with the use of the immunohistochemical method with antiserum to @entity1 neurophysins, which did not cross-react with @entity4545 (ACTH), @entity71035 . All of ten pituitary glands obtained by autopsy revealed the presence of neurophysin-positive cells in the anterior, intermediate, and the posterior lobes. The neurophysin-positive cells were similar to the corticotrophs in shape and distribution. Simultaneous staining for ACTH and neurophysins in the serial sections revealed that neurophysin-positive cells were also ACTH-positive. One hundred twenty-four cases of @entity977 operated upon were investigated. All of 7 @entity652 were composed of neurophysin-positive cells. Six @entity5 with giantism showed sparsely distributed neurophysin-positive cells. No neurophysin-positive cells were observed in any other cases. This study is the first reported evidence of the presence of neurophysins in the @entity1 corticotrophs and @entity977 .
