Beneficial Effects of Adjuvant Intravitreal Bevacizumab Injection on Outcomes of Ahmed XXXX in @entity1 with @entity2297 : Systematic Literature Review.

@entity1 @entity455 @entity548 @entity1713 @entity726 @entity8814 @entity2687 @entity5891 @entity2297
UNASSIGNED: Purpose: We evaluated the effects of adjuvant intravitreal bevacizumab injection on the outcomes of @entity726 valve (AGV) implantation in @entity1 with @entity2297 ( @entity2297 ) through a systematic literature review. Methods: An extensive search of PubMed, EMBASE, and the Cochrane Library was performed in November 2014 for selection of relevant studies. The weighted mean difference of the percentage of intraocular pressure reduction (IOPR%) from baseline to endpoint was used as the primary efficacy estimate, and Mantel-Haenszel odds ratios and 95% confidence intervals (CIs) of the success rate were used as the secondary efficacy estimates. The incidence of adverse events was also documented through a review of the studies. Results: Six studies involving 252 @entity1 (256 eyes) were included in this systematic review. The differences in the means and 95% CIs of the IOPR% of 6 studies showed that adjuvant bevacizumab treatment tended to be more effective than AGV implantation alone. Comparison of the outcomes of AGV implantation only with those of AGV implantation+adjuvant bevacizumab showed a success rate in favor of AGV implantation+adjuvant bevacizumab. The incidence of @entity548 -associated complications such as @entity5891 , @entity548 , and @entity548 was lower in association with combination treatment than with AGV implantation only. Combination treatment seemed to be associated with a lower incidence of other adverse effects such as @entity8814 , flat chamber, @entity1713 /effusion, @entity455 , and @entity2687 . Conclusion: AGV implantation with adjuvant bevacizumab was more effective and had a higher success rate than surgery alone for lowering IOP in @entity1 with @entity2297 . The combined procedure tended to show a lower incidence of @entity548 -associated complications, such as @entity5891 .
