Hemodynamic effects of XXXX in @entity235 endotoxin shock.

@entity712 @entity235 @entity591 @entity880 @entity3044 @entity413 @entity2388
Myocardial function and peripheral hemodynamic alterations were measured through the late stages of @entity235 endotoxin shock. 60 min postendotoxin paired animals were given infusions of either 5 ml/kg per hr of 5% @entity413 or @entity413 plus @entity3044 (0.25 mug/kg per min). Comparable blood lactic and @entity2388 levels were determined, the excess @entity880 calculated, and pH values were obtained. During the initial stages the classic pattern of hemodynamic alterations was observed; an excess of @entity880 appeared and the pH decreased. Outstanding was evidence of markedly reduced myocardial function in the late stages of shock with progressive rise in left ventricular end diastolic pressure (LVEDP), low cardiac index, rise of central venous pressure, increased central blood volume, @entity591 , and declining arterial pressure. Analyses of left ventricular function curves also indicated @entity712 . Infusion of @entity413 alone failed to decrease mortality rate (10 of 18 dying), whereas the rate was significantly decreased with @entity3044 (2 of 18). @entity413 infusion did not benefit myocardial function. @entity3044 resulted in a marked improvement in myocardial action with a significant increase in heart work associated with, yet very minor, increments of LVEDP. In addition, @entity591 subsided, peripheral resistance decreased, and the blood pressure stabilized. The prognostic value of excess @entity880 was doubtful but a progressive fall in later stages was associated with survival.
