Blunted postprandial reaction of portal venous flow in XXXX , assessed with duplex Doppler: significance for prognosis.

@entity1 @entity409 @entity1009 @entity548
To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 @entity1 with @entity409 and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 @entity1 and 21 healthy subjects. Postprandial portal venous diameter, blood velocity and quantitative flow were measured for 60 min. Mean baseline values were: 11.4 mm versus 10.2 mm (p = 0.019), 10.8 cm.s-1 versus 13.4 cm.s-1 (p = 0.015) and 668 ml. @entity1009 versus 646 ml. @entity1009 (p = 0.7) respectively. Spleen size was 15.0 cm versus 10.6 cm (p = 0.0001) respectively. Postprandial diameter, velocity and flow increased significantly in @entity1 and controls (p = 0.0001 for all). Mean postprandial flow could best be described by a polynomial equation with a parabolic curve. @entity1 ' curves were more blunted than controls', with significantly different regression constants (p = 0.025 and p = 0.029). All subjects were followed up for survival and variceal @entity548 . The mean follow-up time was 47 months. Early maximum postprandial velocity (p = 0.041) and large spleen size (p = 0.002) were significantly related to an unfavourable prognosis for survival. Early maximum velocity was also related to @entity548 . This study shows that postprandial portal venous flow is blunted in @entity1 with @entity409 . Postprandial portal venous flow may have prognostic significance.
