Development and psychometric properties of the Pulmonary-specific Quality-of-Life Scale in lung transplant XXXX .

@entity1 @entity82 @entity26 @entity147 @entity148 @entity358
BACKGROUND: The Pulmonary-specific Quality-of-Life Scale (PQLS) was developed to measure quality of life (QoL) among @entity1 awaiting lung transplant. The objective of this study was to determine the psychometric properties of the PQLS, identify empirically derived sub-scales, and examine ability to detect changes in pulmonary-specific QoL scores after lung transplantation. METHODS: Data were derived from the INSPIRE trial, a dual-site randomized controlled trial of coping skills training in 389 lung transplant candidates (obstructive [48.3%], restrictive [24.2%], cystic @entity82 [13.6%], and other [13.9%]). Cronbach alpha was calculated to assess the internal reliability of the PQLS (n = 388). Test-retest reliability was assessed with correlation coefficients between baseline and 12-week post-baseline scores for the usual care control condition (n = 140). Convergent validity was assessed with correlation coefficients between the PQLS and established measures of @entity147 , 6-minute walk test distance, forced expiratory volume in 1 second, and use of supplemental @entity26 at rest (n = 388). Change from baseline to 6 months post-transplantation was assessed with repeated measures analysis of variance (n = 133). RESULTS: The PQLS was internally reliable and stable across 12 weeks. The PQLS correlated strongly with QoL measures (e.g., Shortness of Breath Questionnaire, r = 0.78, p < 0.0001), moderately with mood and @entity148 (e.g., Beck Depression Inventory-II, r = 0.59, p < 0.0001), and modestly with @entity358 severity (e.g., 6-minute walk test, r = -0.41, p < 0.0001). PQLS scores improved by nearly 2 SDs after transplant. CONCLUSIONS: These results demonstrated the reliability, validity, and sensitivity to change of the PQLS for measuring pulmonary QoL among @entity1 with @entity358 and the responsiveness of the PQLS to changes in QoL after lung transplantation.
