Coronary artery operation supported by the Hemopump: an experimental study on XXXX .

@entity1 @entity1707 @entity67 @entity7368
Twelve @entity1707 undergoing coronary artery bypass grafting had the Hemopump to decompress the heart and as circulatory support. The @entity1707 also were given a short-acting beta-blocker, @entity7368 , to make the heart flaccid. Extracorporeal circulation was not used. During Hemopump support, a bolus dose of 0.5 to 5 mg/kg of @entity7368 was given before incremental titration steps from 100 to 600 micrograms.kg-1.min-1 over 15 to 20 minutes. The internal thoracic artery was sutured to the distal part of the left anterior descending artery. The Hemopump was withdrawn to the aorta after a weaning period of 20 to 30 minutes. Seven of 12 @entity1707 went through the whole procedure and the Hemopump was weaned off without complications. Five animals died due to @entity67 in association with @entity7368 administration. There was a big interindividual difference in @entity7368 dose-response curves in the surviving animals. No significant differences in the hemodynamic variables were observed during the experiment. The Hemopump in combination with a short-acting beta-blocker could be an alternate way of performing coronary artery bypass grafting in selected @entity1 .
