Association study of the @entity4047 variant @entity70596 in atopic diseases and XXXX .

@entity1 @entity4047 @entity6 @entity565 @entity1198 @entity29 @entity4932 @entity7647 @entity70596 @entity309
BACKGROUND: It has previously been shown that various inflammatory diseases, such as @entity6 , @entity565 , chronic @entity29 , and @entity309 , are in some circumstances genetically linked to the same chromosomal regions. Consequently, common genes underlying the pathogenetics of these diseases have been proposed. Chronic inflammatory disorders can be subdivided by their predominant immune response, either @entity1198 or TH2. For example, @entity4932 ( @entity4932 ) is a @entity1198 disease, and @entity565 is a TH2 disease. OBJECTIVES: The present study investigated the polymorphism @entity70596 within the @entity4047 gene, a strong TH2 cytokine. We attempted to determine whether it is associated with these 2 diseases and whether this would reflect the @entity1198 /TH2 paradigm. METHODS: @entity70596 was typed in 4 different populations: asthmatic @entity1 , atopic @entity1 , @entity1 with @entity4932 , and a control population. Statistical analysis was performed by using logistic and linear regression analysis of serum IgE levels and the Armitage trend test. RESULTS: The variant @entity7647 110 was shown to be associated with increased total serum IgE levels in our atopic population (P =.006) and was weakly associated with @entity565 (P =.04). There was no association of the variant with @entity4932 when compared with the control population. However, the variant Gln110 was significantly less frequent in @entity1 with @entity4932 compared with its presence in @entity1 with @entity565 (P =.007). CONCLUSION: This is the first study to compare the same gene variant in @entity1198 and TH2 chronic inflammatory diseases. The results suggest that the same gene variant might protect from one disease and make an individual susceptible to the other.
