Positive impact of hormone replacement therapy on the fibrinolytic system: a long-term randomized controlled study in healthy postmenopausal XXXX .

@entity1 @entity172 @entity2289 @entity5709 @entity3479 @entity65
BACKGROUND: The mechanisms by which postmenopausal hormone replacement therapy (HRT) may influence risk of @entity65 are still unclear. Impaired fibrinolytic function is associated with an enhanced risk of @entity65 and therefore the effect of HRT on fibrinolysis may be of importance. OBJECTIVES: To investigate the prolonged effect of HRT on the fibrinolytic system and to determine whether two common polymorphisms in the @entity2289 ( @entity2289 ) and @entity3479 ( @entity3479 ) genes modulate this effect. METHODS: Healthy postmenopausal @entity1 (n = 248) were randomized to HRT (n = 122) or no substitution (n = 126) 5 years prior to investigation. RESULTS: Significantly higher values of @entity3479 activity and lower values of @entity2289 activity and @entity2289 antigen were found in the HRT group compared with the control group. This effect was independent of smoking and without influence from the two common polymorphisms @entity2289 -675(4G/5G) and @entity3479 intron8ins311. Furthermore, no difference between opposed @entity172 (with @entity5709 as the gestagen component) and unopposed @entity172 therapy was found. Both an intention-to-treat and a per-protocol analysis were performed and similar results were obtained. CONCLUSIONS: Long-term treatment with HRT in healthy postmenopausal @entity1 was found to be associated with a beneficial fibrinolytic profile. This effect was found independent of smoking status, opposed and unopposed @entity172 therapy had equal effect, and no influence of the two common polymorphisms @entity2289 -675(4G/5G) and @entity3479 intron8ins311 was found. This effect of HRT on fibrinolytic capacity may be one of the beneficial effects of HRT in relation to @entity65 .
