Sex-specific determinants of serum XXXX concentrations in an elderly German cohort: a cross-sectional study.

@entity1 @entity14282 @entity102 @entity461 @entity14951 @entity560
BACKGROUND: Considering the suggested link between @entity560 insufficiency and several @entity102 , attention should be given to approaches for improving @entity560 status. Elderly subjects are regarded as a high-risk group for developing an insufficient @entity560 status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of @entity560 status are rarely investigated. The purpose of this study is to identify the main predictors of serum @entity14951 [ @entity14282 ] concentrations in elderly subjects by taking into account potential sex differences. METHODS: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96  years. Serum @entity14282 concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of @entity14282 concentrations stratified by sex. RESULTS: Median @entity14282 concentration was 64  nmol/L and none of the subjects had @entity14282 concentrations   <   25  nmol/L. In @entity1 , intact @entity461 (iPTH) (b   =   -0.323), % total body fat (b   =   -0.208), time spent outdoors (b   =   0.328), month of blood sampling (b   =   0.229) and intake of @entity560 supplements (b   =   0.172) were the predominant predictors of @entity14282 , whereas in @entity1 , iPTH (b   =   -0.254), smoking (b   =   -0.282), physical activity (b   =   0.336) and monthly household net income (b   =   0.302) predicted @entity14282 concentrations. The final regression models accounted for 30% and 32% of the variance in @entity14282 concentrations in @entity1 and @entity1 , respectively. CONCLUSION: The findings indicate that @entity14282 concentrations are influenced by body composition, month of blood sampling, economic factors, lifestyle, supplement intake and iPTH, but may not be associated with age, sex, dietary factors, kidney function and presence of selected @entity102 in community-dwelling elderly. Furthermore, our results provide evidence for sex-specific determinants of the @entity560 status, which ought to be considered for preventive strategies.
