Effect of XXXX on endocytosis, cytokine production and lysosomal enzyme activity of a microglial cell line.

@entity14018 @entity650 @entity10815 @entity3265 @entity303 @entity6190 @entity379 @entity1192
@entity3265 is a natural lysosomotropic compound. Concentrations of @entity6190 > 2 mM impaired the phagocytic activity of BV-2 cells, an immortalized microglial cell line, as was determined by the uptake of fluorescent latex microspheres of different sizes. In contrast, an increase in the uptake of fluorescent dextran was observed with the elevation in @entity6190 concentrations. This indicates that @entity3265 affects phagocytotic and pinocytotic activities of BV-2 cells differently. @entity379 - and @entity14018 -stimulated secretion of @entity1192 as well as LPS-stimulated secretion of @entity650 decreased with an elevation in @entity6190 concentrations. The constitutive secretion of @entity1192 was not significantly affected by @entity6190 . However, an increase in LPS-stimulated @entity1192 secretion was observed at 10 mM and 20 mM @entity6190 . High concentrations of @entity3265 affected the activity of lysosomal enzymes of the BV-2 cells. Acid phosphatase and alpha-glucosidase activities increased with the increase in @entity6190 up to 20 mM. The activity of @entity10815 was increased at 5 mM, but decreased at higher @entity3265 concentrations. The effects of @entity3265 on microglial functions are discussed with respect to pathogenetic mechanisms of @entity303 of the Alzheimer type.
