Inhalation toxicity studies with XXXX .

@entity8 @entity308 @entity146 @entity39 @entity11939 @entity50584 @entity35 @entity1388 @entity72875
An acute study of @entity50584 ( @entity72875 ) in @entity35 indicated the 4-hr LC50 to be 1.21 mg/liter. In a 2-week study, all animals exposed to 180 mg/m3 died prior to the sixth exposure, @entity35 exposed at concentrations of 66 and 24 mg/m3 showed clinical signs of @entity146 , body @entity308 , increased lung weights, and depressed liver weights. Histopathology showed @entity39 and pyknosis of the proximal tubular epithelium of the kidneys. This effect was limited to the high-concentration exposure group. Based on the results of these studies, Fischer 344 @entity35 were exposed 6 hr/day, 5 days/week for 13 weeks to a respirable, liquid aerosol of @entity72875 at concentrations of 0, 2.0, 6.0, and 17 mg/m3. One @entity35 in the high exposure group died. The most significant finding in this group was @entity39 of the proximal tubular epithelium of the kidneys. Other observations noted during the study included dried material around the nose and mouth, rales and @entity11939 , reversible @entity308 of serum total protein and globulin concentrations, and increases in urinary, serum, and bone @entity1388 amounts. In the lower exposure groups, findings of @entity146 were minimal. All observations occurred in a dose-related pattern. Based on this study, exposure to @entity72875 at 17 mg/m3 resulted in @entity8 , while exposure at 6 mg/m3, although showing elevations of @entity1388 amounts, did not result in a toxic response.
