A Pilot Study on Oral Health Status as Assessed by an Active XXXX (aMMP-8) Chair-Side Mouthrinse Test in Adolescents.

@entity1 @entity75 @entity1547 @entity2521 @entity5952
UNASSIGNED: @entity5952 is a major destructive collagenase involved in @entity2521 and can be regarded as @entity2521 biomarker. A neutrophil @entity5952 (aMMP-8) oral fluid immunoassay has recently been demonstrated to be a @entity2521 risk indicator, among adults. AIM: Our aim was to investigate a chair-side point-of-care mouthrinse test (Periosafe) based on aMMP-8 immunoassay could identify @entity1 with oral inflammatory burden ( @entity2521 and @entity1547 ) among adolescents with early pathological findings. METHODS: This cross sectional study was carried out at the Kotka Health Center, Finland. First, PerioSafe aMMP-8 chair-side mouthrinse test was performed on enrolled subjects (adolescents aged 15 to 17 year-old, n=47), and the results were read based on a color change within 5 minutes. Then, full-mouth clinical parameters of oral health were assessed including periodontal, oral mucosal and @entity1547 status. RESULTS: The sensitivity and specificity of the neutrophil collagenase-2 immunoassay for BOP positives was 71.8 % and specificity 77.5 % (p=0.018), for at least one >=  4 mm deep pocket 48.3 % and 100 % (0<0.0001), at least two >= 4 mm deep pockets 63.6 % and 100 % (p<0.0001), more than two >=  4 mm deep pockets 76.5 % and 96.8 % (p< 0.0001), respectively. Regarding @entity2521 (at least one >=  4 mm deep pocket ) hardly any false positive could be identified. The sensitivity of the neutrophil collagenase-2 immunoassay for at least one @entity75 was 76.5 % and specificity 96.7 % (p<0.01). CONCLUSION: PerioSafe aMMP-8 chair side-test analyzing mouthrinse a @entity5952 showed promising results in recognition of oral inflammatory burden in adolescents with early initial signs of @entity2521 in 5 minutes. @entity75 could also be detected, but less efficiently.
