Bacterial Lysate Increases the Percentage of Natural Killer T Cells in Peripheral Blood and Alleviates Asthma in XXXX .

@entity1 @entity565 @entity379 @entity1729 @entity3646 @entity688
AIMS: To assess the efficacy of conventional treatment combined with bacterial lysate [OM-85 Broncho-Vaxom (BV)] in the prevention of @entity565 in @entity1 as well as its influence on the number of natural killer T (NKT) cells and their cytokine production. MATERIALS AND METHODS: Sixty @entity1 diagnosed with @entity565 were divided into either a BV-treated group (with oral OM-85 BV) or a conventional inhaled corticosteroid (ICS) group. The numbers of NKT cells and CD4+ NKT cells were measured in the peripheral blood by flow cytometry. The levels of @entity379 , @entity3646 , and @entity688 after the blood cells had been cultured with an NKT cell agonist were detected by ELISA. RESULTS: After therapy, @entity565 attacks were significantly decreased compared with before therapy in both groups. However, after therapy, @entity1729 were reduced compared with before therapy in the BV-treated group only. Additionally, the frequency of @entity565 attacks and use of antibiotics in the BV-treated group were lower than in the ICS group. With BV treatment, the numbers of peripheral blood NKT cells and CD4+ NKT cells were higher after therapy than before therapy. After therapy, the ratio of @entity379 / @entity3646 and @entity688 levels were increased in the BV-treated group, whereas @entity3646 was reduced in the BV-treated group compared with the ICS group. CONCLUSION: BV combined with conventional @entity565 treatment can prevent recurrent @entity1729 and suppress the severity of @entity565 attacks, possibly by altering the rates and cytokines of NKT cells.    2015 S. Karger AG, Basel.
