Th17 cells reflect colon submucosal pathologic changes in active eosinophilic XXXX with @entity2883 .

@entity1 @entity404 @entity4725 @entity7 @entity1333 @entity9757 @entity565 @entity4 @entity694 @entity4155 @entity2883 @entity2071 @entity14761
BACKGROUND: @entity9757 ( @entity9757 ) or @entity14761 ( @entity14761 ), or both, with @entity565 precede the onset of eosinophilic @entity2883 with @entity2883 (EGPA) in half of all EGPA @entity1 . It is not known what determines whether @entity1 with @entity9757 or with @entity14761 following @entity565 will develop EGPA. METHODS: We studied 17 EGPA @entity1 and 12 @entity1 with @entity9757 but without EGPA. We assayed serum @entity2071 , @entity4725 , and @entity7 , and the percentage of peripheral blood @entity404 (+) T cells producing @entity4155 (Th17 cells), at both onset and remission. We also examined the numbers of submucosal eosinophils and the basement membrane-to-crypt and crypt-to-crypt distance to evaluate @entity4 in the colon submucosa at onset and remission in EGPA and at onset in @entity9757 . RESULTS: Nine of 12 (75.0  %) @entity9757 @entity1 had symptoms or endoscopic findings. Colonic submucosal eosinophil counts and @entity4 in EGPA at onset were greater than at remission or in @entity9757 at onset. Th17 cells (%) and serum @entity2071 levels at onset were greater in EGPA than in @entity9757 . In EGPA, peripheral blood Th17 cells (%) were significantly correlated with serum @entity2071 level, colonic submucosal eosinophil count, and degree of @entity4 change; inversely correlated with serum @entity7 level; but not correlated with @entity4725 level. CONCLUSIONS: @entity694 change were greater in EGPA than in @entity9757 . The mechanism of @entity1333 in EGPA appears related to increases in serum Th17 cell numbers and @entity2071 levels and decreases in @entity7 levels.
