Juvenile xanthogranuloma of the oral cavity in XXXX : a clinicopathologic study.

@entity1 @entity14705 @entity146 @entity75 @entity6725 @entity7468 @entity469 @entity4085 @entity13929 @entity4896
PURPOSE: This clinicopathologic study describes the histopathologic, immunocytochemical, and electron microscopic features of oral @entity6725 ( @entity6725 ) in @entity1 . DESIGN: The study population consisted of 5 @entity1 (5 months to 10 years of age) with biopsy-proven JXGs obtained for consultation. RESULTS: Lesion sites were @entity14705 , and tongue and were described by the clinicians as (1). @entity146 fibroma; (2). granulation tissue; (3). pedunculated granular nodule; (4). @entity75 ; and (5). brown-red umbilicated papule. Tissue was available for histopathologic (n = 5), immunocytochemical (n = 5), and ultrastructural (n = 3) studies. Three cases showed early @entity6725 lesions possessing abundant histiocytes, but lacking @entity7468 . The other 2 cases had classic @entity6725 lesions with vacuolated histiocytes and @entity7468 . Immunocytochemical findings were (1). @entity469 (KP1, @entity13929 ), moderate to diffuse; (2). fascin, moderate to diffuse; (3). factor XIIIa, focal to diffuse; (4). alpha-1-antitrypsin, moderate to diffuse; (5). S-100 protein, focal to diffuse; and (6). @entity4896 , negative in all cases. Ultrastructural examination displayed histiocytic and dendritic cells lacking pentalaminar structures (Birbeck granules). CONCLUSION: JXGs of the oral cavity vary in their clinical and histopathologic appearances and necessitate that @entity4085 ( @entity4085 ) be excluded. @entity6725 and @entity4085 may occur concurrently, before or after each other, in some @entity1 .
