Serum @entity2313 and risk of XXXX and all-cause mortality in the Framingham Offspring Study.

@entity1 @entity2313 @entity101 @entity301 @entity583 @entity204 @entity65 @entity165
BACKGROUND: @entity301 remains the leading cause of @entity204 in the United States. The association between serum @entity2313 and @entity65 remains controversial. We used data collected prospectively from @entity1 of the Framingham Offspring Study to assess whether a lower concentration of serum @entity2313 was associated with an increased risk of @entity583 ( @entity583 ) and all-cause mortality. METHODS AND RESULTS: During 21.9 years of mean follow-up, 280 cases of @entity583 occurred. From the highest to the lowest tertile of serum @entity2313 , crude incidence rates of @entity583 were 26.7, 46.7, and 67.8 cases per 10 000 @entity1 -years, respectively, for @entity1 and 5.9, 15.0, and 16.8 cases per 10 000 @entity1 -years, respectively, for @entity1 . In a Mantel-Haenszel method adjusting for age, total @entity165 , and @entity101 , lower serum @entity2313 was associated with an increased risk of @entity583 in both sexes. From the highest to the lowest tertile of @entity2313 , the adjusted hazard ratios (95% CI) of @entity583 were 1.0 (reference), 1.25 (0.84 to 1.84), and 1.49 (1.01 to 2.21), respectively, for @entity1 and 1.0, 1.79 (0.88 to 3.65), and 2.12 (1.06 to 4.27), respectively, for @entity1 . The @entity2313 - @entity583 association was stronger among @entity101 subjects in both sexes. In addition, low @entity2313 was associated with an increased rate of all-cause mortality in @entity1 . CONCLUSIONS: Lower serum @entity2313 concentrations appear to be associated with an increased risk of @entity301 in both sexes and with all-cause mortality in @entity1 and could help along with traditional risk factors in identifying @entity1 at risk of @entity583 .
