Abnormal functional connectivity in XXXX .

@entity1 @entity2414 @entity75 @entity1005
This study investigated the efficacy of a combined multivariate/resampling procedure for the analysis of PET activation studies. The covariance-based multivariate analysis was used to investigate distributed brain systems in @entity1005 ( @entity1005 ) @entity1 and matched controls during performance of a working memory task. The results were compared to univariate results obtained in an earlier study. We also examined whether the @entity1005 @entity1 demonstrated a breakdown in functional connectivity that may be associated with working @entity2414 often experienced by these @entity1 . A resampling procedure was used specifically to test the reliability of measured between-group effects, to avoid mistaken inference on the basis of random intersubject differences. Significant and reproducible differences in network connectivity were obtained for the two groups. The functional connectivity pattern of the @entity1 group was characterized by relatively more activation in the bilateral inferior parietal lobes and the left precentral gyrus than the control group, and less activation in the inferior medial frontal lobe, bilateral middle frontal gyri and right inferior temporal gyrus. The resampling procedure provided direct evidence that working memory updating was abnormal in @entity1005 @entity1 relative to matched controls. This work focuses on the need to identify extended brain networks (in addition to regionally specific changes) for the full characterization of brain responses in neuroimaging experiments. Our multivariate analysis explicitly measures the reliability of the patterns of functional connectivity we obtain and demonstrates the potential of such analyses for the study of @entity75 in psychopathology.
