Comparison of DNA content, S-phase fraction, and survival between medullary and XXXX .

@entity1 @entity0 @entity5 @entity189 @entity2802 @entity513 @entity982
@entity189 ( @entity189 ) of the breast has been regarded as a subtype of @entity0 with a relatively favorable prognosis despite its high nuclear grade and high mitotic index. High nuclear grade and high mitotic index have been correlated with DNA aneuploidy and high S-phase fraction (SPF) by flow cytometry. Generally in @entity0 , these histologic and DNA content features predict a less favorable prognosis. To address this paradox, all cases of @entity189 of the breast (20 of 1,365 @entity189 [1.5%]) diagnosed between 1968 and 1982 were compared to age- and stage-matched cases of @entity513 ( @entity513 ) diagnosed during the same time period. All of the @entity189 and 80% of the @entity513 had one or more DNA aneuploid stem lines. Average total SPF was 8.1% for @entity189 and 4.8% for @entity513 . DNA analysis was performed from @entity982 blocks (average CV: 4.5% DNA diploid; 4.1% DNA aneuploid), and subjected to computer modeled analysis. Statistically significant differences between presence or absence of DNA aneuploidy (P = .035) and total SPF (P = .029) were demonstrated between the two groups. Thirteen of 20 @entity1 (65%) with @entity189 (average followup 130 months) were alive at the end of the study period compared to 12 of 20 @entity1 (60%) with @entity513 (average follow-up 160 months). The difference in crude survival was not statistically significant (P = .867). However, there was a tendency toward early death in @entity189 and late death in @entity513 . Within the @entity2802 stage-matched @entity1 , no significant difference was demonstrated for @entity5 size or nodal status when these variables were examined separately. In conclusion, statistically significant differences in DNA content and proliferative fraction exist between @entity189 of the @entity0 . The biologic and clinical differences demonstrated in this analysis warrant careful consideration before including cases of @entity189 in studies evaluating newer prognostic variables in @entity0 .
