XXXX reverses drug resistance in @entity150 cells.

@entity1 @entity2591 @entity900 @entity938 @entity150 @entity1205
BACKGROUND: @entity1 with metastatic and muscle-invasive @entity150 are commonly treated with @entity900 . A significant proportion of @entity1 develop disease progression after an initial response to chemotherapy. Presently there is no standard of care for such @entity1 . We examined whether pretreatment with an epigenetic agent would result in reversal of drug resistance. MATERIALS AND METHODS: Methylation of proapoptotic and cell cycle genes in @entity150 cells was examined. @entity900 - and @entity1205 -resistant cells were generated. The effect of target of methylation-induced silencing ( @entity938 ) expression and pretreatment of wild-type and drug-resistant cells with @entity2591 on chemosensitivity was determined. RESULTS: Unidirectional crossresistance of @entity900 -resistant UMUC3 cells to @entity1205 was observed. Recombinant expression of @entity938 or pre-treatment of wild-type and drug-resistant cells with @entity2591 resulted in enhanced sensitivity to @entity900 and @entity1205 . CONCLUSION: Our results indicate that epigenetic therapy may restore sensitivity to chemotherapeutic agents in @entity150 cells.
