Prognostic factors in stage T1 XXXX : @entity5 pattern (solid or papillary) and vascular invasion more important than depth of invasion.

@entity1 @entity189 @entity150 @entity5
OBJECTIVES: We studied the prognostic factors for progression and disease-specific survival in @entity1 with Stage T1 @entity150 to identify subgroups with different prognoses. METHODS: All 121 @entity1 with Stage T1 @entity150 at first diagnosis in 1987 to 1988 in a large region were prospectively registered. The histopathologic material and the clinical records were reviewed. We performed univariate and multivariate analyses of the clinical and pathologic factors of potential significance for the time to progression and disease-specific survival. At the end of the study, only 18 @entity1 (15%) were alive and had been followed up for a median of 15 years. RESULTS: On univariate analysis, vascular invasion, @entity5 pattern, deep invasion, grade 3 disease, and @entity189 in situ were associated with an increased risk of progression. The multivariate analysis showed that only vascular invasion and @entity5 pattern had independent prognostic value for progression. Vascular invasion and a @entity5 pattern also had independent prognostic value for disease-specific survival. CONCLUSIONS: @entity1 who have Stage T1 @entity150 with a @entity5 pattern and/or vascular invasion have a very poor prognosis when treated with transurethral resection only. It is unknown whether intravesical bacille Calmette-Gu  rin treatment can improve the poor prognosis in such cases.
