Changes in very low density lipoprotein particle size and production in response to XXXX feeding and @entity3190 .

@entity844 @entity1735 @entity4053 @entity969 @entity3190 @entity412 @entity35 @entity413
The effects of chronic (2 weeks) @entity3190 on the production of very low density lipoprotein (VLDL) @entity412 and on VLDL particle size were examined. @entity3190 was induced by a constant sc infusion of 6 U porcine insulin/day from an osmotic minipump. To avoid profound @entity4053 , these @entity35 received chow plus 10% @entity969 in their drinking water. Therefore, two control groups were examined; one receiving chow plus the same amount of @entity969 (high @entity1735 control) and the other receiving chow only (chow control). The constant infusion model was compared to a previously reported model of @entity3190 . In that model, NPH insulin was injected for 2 weeks twice daily in incrementally increasing doses (final dose, 6 U/day) into @entity35 that were also fed chow and given 10% @entity969 drinking water. Results with the injection model were similar to those previously reported: an increase in @entity412 production in face of a decrease in FFA, a minimal decrease in serum @entity412 , and some decrease in serum @entity413 . The infusion model produced the same increase in @entity412 production and decrease in @entity844 concentration. However, it differed in producing an increase in serum @entity412 and no change in serum @entity413 . The former suggested that in the infusion model @entity412 removal was not stimulated as much as in the injection model. Since there was no @entity4053 in the infusion model, it was unlikely that VLDL changes were caused by an increase in counter regulatory hormones. VLDL particle size was increased in the high @entity1735 controls. This indicated that changes in @entity969 supplementation led to the production of more @entity412 -filled VLDL particles. @entity3190 was not accompanied by any further increase in particle size. Thus, the @entity3190 -induced increase in VLDL- @entity412 production was accompanied by an equivalent increase in VLDL particle production.
