Variation in the risk of XXXX following colectomy.

@entity5 @entity1 @entity1211
BACKGROUND: Guidelines recommend extended thromboprophylaxis following colectomy for @entity5 , but not for non- @entity5 . The aim of this study was to determine absolute and relative rates of @entity1211 ( @entity1211 ) following colectomy by indication, admission type and time after surgery. METHODS: A cohort study of @entity1 undergoing colectomy in England was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data (2001-2011). Crude rates and adjusted hazard ratios (HRs) were calculated for the risk of first @entity1211 following colectomy using Cox regression analysis. RESULTS: Some 12   388 @entity1 were identified; 312 (2  5 per cent) developed @entity1211 after surgery, giving a rate of 29  59 (95 per cent c.i. 26  48 to 33  06) per 1000 @entity1 -years in the first year after surgery. Overall rates were 2  2-fold higher (adjusted HR 2  23, 95 per cent c.i. 1  76 to 2  50) for emergency compared with elective admissions (39  44 versus 25  78 per 1000 @entity1 -years respectively). Rates of @entity1211 were 2  8-fold higher in @entity1 with @entity5 versus those with non- @entity5 (adjusted HR 2  84, 2  04 to 3  94). The rate of @entity1211 was highest in the first month after emergency surgery, and declined from 121  68 per 1000 @entity1 -years in the first month to 25  65 per 1000 @entity1 -years during the rest of the follow-up interval. Crude rates of @entity1211 were similar for malignant and non- @entity5 (114  76 versus 120  98 per 1000 @entity1 -years respectively) during the first month after emergency surgery. CONCLUSION: @entity1 undergoing emergency colectomy for non- @entity5 have a similar risk of @entity1211 as @entity1 with @entity5 in the first month after surgery.
