Protection by @entity558 -induced inhibitory XXXX (+) cells on corneal allograft.

@entity1 @entity558 @entity19347 @entity19 @entity8932 @entity3804
OBJECTIVE: It is widely reported that @entity3804 (+)Gr1+ myeloid-derived suppressor cells can cause allograft tolerance in @entity19 and @entity1 , however, little is known on the therapy role in chronic transplantation rejection. In this paper, their role in corneal transplantation was studied for the first time. METHOD: Inhibitory @entity3804 (+) cells were obtained by @entity19 @entity558 -induced septic model. Phenotype, endocytosis, antigen presenting ability, and T cell suppression assays were performed by flow cytometry analysis. The suppressive ability in vivo was analyzed by targeting allogeneic corneal transplantation. RESULTS: @entity558 was intraperitoneally injected into C57BL/6 @entity19 , the percentage of @entity3804 (+) Gr1+ cells was increased in @entity19 spleen, blood, and bone marrow, respectively. Compared with control @entity19 , @entity19347 , @entity8932 , and MHC-11 expression were higher in @entity558 treated @entity19 . @entity3804 (+) Gr1+ cells could inhibit allogenic corneal reaction in vivo after adoptive transfer, in consistent with an observation of inhibition effect on the antigen presenting cells (APCs) and CD4+ T cells proliferation in vitro. CONCLUSION: @entity3804 (+) cells induced by @entity558 could function as inhibitory APCs, suppress CD4+ T cells proliferation and improve corneal allograft survival. Predictly, its application for cells transfer therapy in clinic in the further.
