Effects of XXXX on the function of dendritic cells in @entity1 with rheumatic arthritis.

@entity1 @entity32 @entity2937 @entity3413 @entity310 @entity4155 @entity1199 @entity3646 @entity688 @entity2841 @entity309
The present study examined the functional profile of dendritic cells (DCs) in @entity1 with @entity309 ( @entity309 ) and the effects of @entity3413 on the function of DCs. A total of 40 @entity1 who was recently diagnosed as having @entity309 were equally assigned to two groups: the routine treatment group (group R) and the routine treatment plus @entity3413 group (group R+S). Twenty healthy individuals served as control. The peripheral blood mononuclear cells (PBMCs) were isolated before and 4 weeks after the treatment and then cultured with @entity3646 ( @entity3646 ) and @entity2841 ( @entity2841 ) to prepare mature DCs. The expression of co-stimulating factor @entity2937 on the surface of DCs was assessed by flow cytometry. And the stimulating capacity of DCs was measured by mixed lymphocyte reaction (MLR). The contents of cytokines in culture supernatants of DCs in MLR were detected by ELISA. Blood lipids and high-sensitivity C-reactive protein (hs-CRP) were detected. The relationship between the expression of @entity2937 and the blood CRP level was also investigated. The results showed that, as compared with the control group, the @entity2937 expression and the level of cytokines secreted by DCs were significantly increased in @entity309 @entity1 and greater stimulating capacity of DCs in MLR was demonstrated in @entity309 @entity1 . T lymphocytes in MLR secreted higher levels of proinflammatory cytokines ( @entity1199 , @entity4155 , @entity310 and INF-y) and lower level of anti- @entity32 cytokine ( @entity688 ). The function of DCs was markedly weakened and the level of hs-CRP and low-density lipoprotein was substantially lowered in group R+S in comparison to group R. The @entity2937 expression was positively correlated with hs-CRP. It was concluded that DCs in @entity309 are highly activated and DC-initiated immune reaction may play an important role in the pathogenesis of @entity309 . @entity3413 administration can significantly inhibit the DCs function and reduce the level of hs-CRP, indicating the suppression on inflammatory reaction may be one of the mechanisms by which @entity3413 exerts its effect in treating @entity309 .
