Epidemiologic features of XXXX : the Framingham study.

@entity1 @entity6331 @entity712 @entity6 @entity4346 @entity955 @entity65
In the Framingham Study 2325 @entity1 and 2866 @entity1 30 to 62 years old at entry were followed biennially over 22 years for the development of @entity955 in relation to antecedent @entity65 and risk factors. During surveillance, @entity955 developed in 49 @entity1 and 49 @entity1 . The incidence rose sharply with age but did not differ significantly between the sexes. Overall, there was a 2.0 per cent chance that the disorder would develop in two decades. @entity955 usually followed the development of overt @entity65 . Only 18 @entity1 and 12 @entity1 (31 per cent) had @entity955 in the absence of @entity65 . @entity712 and @entity6331 were the most powerful predictive precursors, with relative risks in excess of sixfold. @entity65 was the most common antecedent disease, largely because of its frequency in the general population. Among the risk factors for @entity65 , @entity6 and electrocardiographic evidence of @entity4346 were related to the occurrence of @entity955 . The development of @entity955 was associated with a doubling of overall mortality and of mortality from @entity65 .
