The effect of the antipsychotic drug XXXX and its metabolite @entity70602 on acute inflammation, memory and @entity4270 .

@entity162 @entity308 @entity558 @entity146 @entity19 @entity635 @entity4270 @entity1618 @entity8021 @entity148 @entity161 @entity70602 @entity1089
UNASSIGNED: The atypical antipsychotic drug, @entity1089 , has recently been suggested to not only show efficacy in @entity161 , @entity162 , major @entity308 and general @entity148 , but to also have a possible anti-inflammatory effect, which could be important in the treatment of the inflammatory aspects of @entity146 . Male C57BL/6 @entity19 were given either @entity1089 (i.p. 10mg/kg), its main active metabolite @entity70602 (i.p. 10mg/kg), or saline as a vehicle control, once a day for 14days. On the 14th day, this dose was followed by a single dose of either @entity558 (i.p. 1mg/kg) or saline. 24h post @entity558 short-term recognition memory and @entity4270 behaviour were measured using the Y-maze and @entity8021 preference test respectively. Immediately following behavioural testing, @entity19 were culled before serum, prefrontal cortex and hippocampal analysis of cytokine levels was conducted. It was found that @entity558 challenge led to increased serum and brain cytokine levels as well as @entity4270 , with no significant effect on recognition memory. @entity1089 and @entity70602 both increased levels of the anti-inflammatory cytokine @entity1618 and decreased levels of the pro-inflammatory cytokine IFN-y in serum 4h post @entity558 . Within the brain, a similar pattern was seen in gene expression in the hippocampus at 4h for @entity1618 and Ifn-y, however @entity70602 led to an increase in @entity635 expression in the PFC at 4h, while both drugs attenuated the increased @entity1618 in different regions of the brain at 24h. These effects in the serum and brain, however, had no effect on the observed @entity558 induced changes in behaviour. Both @entity1089 and its metabolite @entity70602 appear to have a partial anti-inflammatory effect on @entity1618 and IFN-y following acute @entity558 challenge in serum and brain, however these effects did not translate into behavioural changes.
