Is the autophagy a friend or foe in the XXXX nanoparticles associated radiotherapy for @entity11 ?

@entity5732 @entity575 @entity5 @entity3963 @entity8836 @entity11 @entity4287 @entity4675
@entity11 is the most common @entity5 with a dismal prognosis. The radiosensitizing effect of @entity575 nanoparticles (AgNPs) on @entity11 both in vitro and in vivo had been demonstrated in the previous studies of our group. However, the underlying mechanism is still unclear. Consistent with previous studies, a size and dose dependent antitumor effect and significant radiosensitivity enhancing effect of AgNPs were observed in our experiment system. We also found that cell protective autophagy could be induced by AgNPs and/or radiation, which was verified by the use of @entity8836 . The mechanism through which had autophagy and the enhancement of radiosensitivity taken place was further investigated with inhibitors of @entity3963 and @entity4675 pathways. We demonstrated that @entity3963 and @entity4675 played pivotal roles in the radiosensitivity enhancement. Inhibiting @entity3963 and @entity4675 with @entity5732 and @entity4287 respectively, we found that the autophagy level of the cells treated with AgNPs and radiation were attenuated. Moreover, @entity4287 down-regulated the apoptosis rate of the co-treated cells significantly. Taken together, the present study would have important impact on biomedical applications of AgNPs and clinical treatment for @entity11 .
