The function and properties of XXXX lung mast cells.

@entity1 @entity2656 @entity748 @entity1672 @entity8172 @entity4443 @entity565 @entity112 @entity223 @entity9992
Mast cells may be recovered from @entity1 subjects by bronchoalveolar lavage. Such bronchoalveolar mast cells will release @entity112 in response to IgE-dependent challenge in a reaction that is dose-, time- and energy-dependent. They possess functional characteristics distinct from dispersed @entity1 lung mast cells. The percentage of mast cells within the bronchoalveolar cell population is critically dependent upon the underlying pathology. Greater numbers of mast cells may be recovered from the bronchoalveolar compartment of extrinsic @entity748 than from controls. In addition, bronchoalveolar mast cells from asthmatic subjects show an increased releasability of @entity112 in response to anti-IgE. Antigen challenge also leads to the release of @entity112 in vitro, demonstrating the potential for the antigen-specific initiation of bronchoconstriction in these subjects. Spontaneous release of @entity112 from bronchoalveolar mast cells of asthmatic subjects was also greater than in controls (up to 46%), a feature which may be related to non-immunological mechanisms of bronchoconstriction. Such non-immunological mechanisms have been further investigated utilising @entity2656 as a model of hyperosmolar @entity112 release. @entity2656 induced a dose-dependent release of @entity112 from bronchoalveolar mast cells of normal subjects, and this release was significantly inhibited by @entity9992 . The @entity4443 are putative major mediators of @entity1 @entity565 . After challenge with anti-IgE in vitro, dose-dependent release of @entity223 and @entity1672 occurs from the bronchoalveolar cells of normal subjects. The release of @entity8172 shows significant correlation with @entity112 release. Lying superficially, bronchoalveolar mast cells would be readily accessible to inhaled antigen. Mediator release from such cells may be relevant to the pathogenesis of @entity565 .
