Breakpoint heterogeneity in (2;3)(p15-23;q26) translocations involving XXXX in myeloid hemopathies.

@entity1 @entity43258 @entity58758 @entity60496 @entity22213 @entity21270 @entity74
Several chromosomal rearrangements involving band 3q26 are known to induce @entity22213 overexpression. They include inv(3)(q21q26), t(3;3)(q21;q26), t(3;21)(q26;q22) and t(3;12)(q26;p13). Translocations involving the short arm of chromosome 2 and 3q26 have been reported in more than 50 @entity1 with @entity74 . However, although the breakpoints on 2p are scattered over a long segment, their distribution had only been analyzed in 9 @entity1 . We performed fluorescent in situ hybridization with a library of BAC (Bacterial Artificial Chromosome) clones in 4 @entity1 with t(2;3)(p15-23;q26). Our results combined with those of the 9 previously reported @entity1 showed scattering of the breakpoints in 2 regions. A 1.08Mb region in band 2p21 encompassing the @entity60496 , @entity58758 and @entity43258 genes was documented in 5 @entity1 . A second region of 1.83Mb in band 2p16.1 was identified in 8 @entity1 . Four @entity1 showed clustering around the @entity21270 gene and the remaining 4 around a long intergenic non-coding RNA, FLJ30838. These regions are characterized by the presence of regulatory sequences (CpG islands and promoters) that could be instrumental in @entity22213 overexpression.
