Tumoral angiogenesis and tissue factor expression during XXXX progression in a transgenic @entity19 model.

@entity5 @entity19 @entity519 @entity1965 @entity1893 @entity157 @entity1611 @entity99
BACKGROUND/AIMS: The hypervascularity described in @entity157 varies according to the progression and the differentiation of the @entity5 , suggesting an angiogenic switch during @entity5 development. METHODS: We used a transgenic @entity19 model of @entity157 induced by the expression of SV40-T antigen, in which male @entity19 developed @entity99 at various temporal and histological stages, whereas female @entity19 remained @entity5 -free. We analyzed, by immunostaining and reverse transcription-polymerase chain reaction, factors involved in @entity5 . RESULTS: We demonstrated that @entity5 occurred before the development of @entity1893 . We showed that some SV40-T-positive cells with an endothelial phenotype are involved in angiogenic processes, suggesting a partial vasculogenic mimicry. This @entity5 is associated with platelet activation due to tissue factor expression in endothelial cells and invading macrophages. Normal and transgenic livers exhibited different pattern of expression of @entity519 -inducible factor 1 alpha ( @entity1965 ) and @entity1611 ( @entity1611 ) mRNA. CONCLUSIONS: This model of @entity157 displays marked @entity5 , with proliferation, remodeling and arterialization of hepatic sinusoids, probably associated with a partial vasculogenic mimicry. Abnormal angiogenesis observed in hepatocarcinoma was associated with platelet activation by tissue factor (TF) produced by endothelial cells and invading macrophages. In this transgenic model, @entity1965 , @entity1611 , and TF play a crucial role in @entity5 .
