Ovine progressive XXXX : experimental intrathoracic, intracerebral, and intra-articular infections.

@entity742 @entity55 @entity2286 @entity603 @entity3554
Three groups of 4 @entity742 each were experimentally infected with an isolate of progressive @entity55 virus ( @entity2286 ) by intracerebral, intra-articular, or intrathoracic routes of inoculation. An additional control group was sham-inoculated by all 3 routes with identically prepared, noninfected inoculum. @entity742 were killed 12 to 42 days after inoculation. A mild generalized @entity3554 was found in 2 of the 4 @entity742 inoculated intracerebrally. A severe, @entity603 with massive infiltration of lymphocytes and plasma cells was found in the 4 @entity742 inoculated intraarticularly. Germinal center formation was found in the synovial membrane 42 days after inoculation. Appreciable differences in lung morphologic features were not observed among the 4 groups. The @entity2286 was isolated from virus-inoculated @entity742 from the choroid plexus, synovium, and lungs from inoculated and noninoculated sites. Nine of the 12 virus-inoculated lambs developed serum antibody to @entity2286 , and specific antibodies were found in the synovial fluid of virus-inoculated joints. Virus was not isolated, lesions were not found, and serum antibody was not demonstrated in sham-inoculated @entity742 .
