Outcome and prognostic factors of postoperative radiation therapy (PORT) after incomplete resection of XXXX ( @entity1149 ).

@entity1 @entity3012 @entity5 @entity1149 @entity3121
PURPOSE: Current guidelines recommend postoperative radiation therapy (PORT) for incompletely resected @entity1149 ( @entity1149 ). However, there is still a paucity of evidence for this approach. Hence, we analyzed survival in 78 @entity1 following radiotherapy for incompletely resected @entity1149 (R1) and investigated prognostic factors. @entity1 AND METHODS: All 78 @entity1 with incompletely resected @entity1149 (R1) received PORT between December 2001 and September 2014. The median total dose for PORT was 60Gy (range 44-68Gy). The majority of @entity1 had locally advanced @entity5 stages (stage IIA (2.6%), stage IIB (19.2%), stage IIIA (57.7%) and stage IIIB (20.5%)). 21 @entity1 (25%) received postoperative chemotherapy. RESULTS: Median follow-up after radiotherapy was 17.7 months. Three-year overall ( @entity3012 ), progression-free (PFS), local (LPFS) and distant progression-free survival (DPFS) rates were 34.1, 29.1, 44.9 and 51.9%, respectively. @entity3012 was significantly prolonged at lower nodal status ( @entity3121 ) and following dose-escalated PORT with total radiation doses >54Gy (p=0.012, p=0.013). Furthermore, radiation doses >54Gy significantly improved PFS, LPFS and DPFS (p=0.005; p=0.050, p=0.022). Interestingly, survival was neither significantly influenced by R1 localization nor by extent (localized vs. diffuse). Multivariate analyses revealed lower nodal status and radiation doses >54.0Gy as the only independent prognostic factors for @entity3012 (p=0.021, p=0.036). CONCLUSION: For incompletely resected @entity1149 , PORT is used for improving @entity5 control. Local progression is still the major pattern of failure. Radiation doses >54Gy seem to support improved local control and were associated with better @entity3012 in this retrospective study.
