Allergen-induced @entity6587 is not a feature of dermal immediate XXXX --in contrast to reactions of airways mucosa.

@entity1 @entity2023 @entity56 @entity112 @entity6587 @entity2021
Allergen challenges of airway mucosa are commonly followed by an increased sensitivity to rechallenge with allergen. In the lower airways this phenomenon has been associated with the late phase of allergic airway reactions, which in turn has been suggested as a link between @entity2021 and @entity56 . The aim of the present investigation was to explore further the phenomenon of allergen-induced @entity6587 and to see whether it was possible to induce such a reaction in the skin. Twenty-six @entity1 with @entity2023 due to birch and/or grass pollens were studied in the pollen-free winter months. Nine of these @entity1 had previously demonstrated an increased reactivity following allergen challenge in the nose, and nine of the @entity1 had cutaneous allergen-induced late-phase reactions to the allergen tested. Skin-prick tests were performed with pollen allergen, @entity112 , and a negative control. The areas of the weal-and-flare reactions were measured 15 min after the tests were set. Any late-phase reactions were recorded 6 hr after the skin challenge. The subjects were re-tested with allergen and @entity112 24 hr after the initial prick test within the area of the corresponding weal from the previous day. In contrast to previous challenges of @entity1 airway mucosa, where the same time interval was used, we found no increased responsiveness to rechallenge as compared with the initial allergen challenge. This was true, even if only the subgroups with previously demonstrated nasal allergen-induced @entity6587 , or cutaneous late-phase reaction were evaluated.(ABSTRACT TRUNCATED AT 250 WORDS)
