Expression of Th17 cell population regulatory cytokines in XXXX - Preliminary study.

@entity1 @entity5 @entity957 @entity189 @entity4155 @entity4452
AIM OF THE STUDY: Aim of the study was to evaluate the potential role of regulatory and proinflammatory cytokines @entity4452 and @entity4155 as Th17 lymphocyte activity markers in relation to invasiveness in @entity5 . MATERIAL AND METHODS: The immunological analysis was conducted in 50 @entity1 treated for @entity957 and 30 healthy volunteers as controls. The levels of @entity4452 and @entity4155 in supernatants of purified peripheral blood mononuclear cell cultures were determined by using the enzyme-linked immunosorbent assay (ELISA). The clinicomorphological criteria included pTNM, stage, G, and the total @entity5 front grading (TFG) score. RESULTS: Our data demonstrated higher concentrations of @entity4452 in @entity1 as compared to controls (p = 0.0001). No statistical difference for @entity4155 in these groups was observed. Our study revealed significant dependences in @entity4452 expression on pT (p = 0.04), histological differentiation (p = 0.04), and TFG total score (p = 0.02). @entity5 (pT3-pT4) with higher grade (G2-G3) and higher invasiveness (> 14 TFG points) were characterised by elevated @entity4452 levels in PBMC supernatants. Our data did not indicate a relationship between cytokine levels and three- and five-year survival. However, a tendency towards lower content of @entity4452 in PBMC cultures in @entity1 who lived longer than five years after treatment was noted. The relationships between @entity4155 level in PBMC cultures and clinicomorphological and prognostic parameters have not been disclosed. CONCLUSIONS: The results of this study suggest the importance of regulatory cytokine @entity4452 in determining the aggressive @entity189 .
