XXXX alters LFA-1alpha expression in @entity35 small intestine.

@entity35 @entity3883 @entity33 @entity1160
Translocation of bacteria and endotoxtin has long been documented in @entity3883 , and altered intestinal barrier function is considered to be one of the important mechanisms for this phenomenon. The regulation of gastrointestinal mucosal response to injury is thus of important clinical as well as biological relevance. Integrins play a critical role in enterocyte migration, which is essential to @entity33 . This study is designed to evaluate the integrins status in @entity3883 . Male @entity35 (N = 37) were randomized to three groups. Group 1 (N = 12) underwent common bile duct ligation (CBDL), group 2 (N = 12) underwent common bile duct ligation with oral @entity1160 administration (CBDL + G), and group 3 (N = 13) underwent a sham operation (sham control). After seven days, segments of proximal jejunum and distal ileum were harvested, and cell surface immunohistochemical expression of LFA-1alpha and VLA-6 were evaluated and recorded. The staining intensities were graded on a scale of 0-4. Comparisons among the three groups were performed. There was no significant difference in VLA-6 staining on small intestine among the three groups (P > 0.05). There was also no significant difference in LFA-1alpha staining the on jejunum between group 1 (CBDL) and group 3 (sham control) (P > 0.05). However, the LFA-1alpha staining on the ileum in group 1 (CBDL) significantly decreased when compared with group 3 (sham control) (P = 0.008). With oral @entity1160 administration (0.2 g/kg body weight, once daily), LFA-1alpha staining on the ileum was significantly restored in group 2 (CBDL + G). In conclusion, @entity3883 for one week down-regulates LFA-1alpha expression on @entity35 ileum. With oral @entity1160 administration, such down-regulation of LFA-1alpha expression on @entity35 ileum can be restored. Such a phenomenon is intriguing and deserves further evaluation and elucidation.
