Polymorphonuclear leukocytes in XXXX : abnormalities in metabolism and function.

@entity1 @entity2175 @entity73 @entity5217 @entity460 @entity141 @entity4854 @entity413 @entity855
OBJECTIVE: To determine basal levels of cytosolic @entity460 ([ @entity141 ]i) and phagocytic activity in polymorphonuclear leukocytes (PMNLs) from @entity1 with @entity2175 ( @entity2175 ). DESIGN: Prospective cohort study. SETTING: A university-county hospital. MEASUREMENTS: Cytosolic @entity460 levels, @entity855 ( @entity855 ) content, and phagocytosis of PMNLs from @entity1 with @entity2175 and from controls. INTERVENTION: In @entity1 with @entity2175 , we evaluated the effect of treatment with an oral hypoglycemic agent ( @entity5217 ) on [ @entity141 ]i levels, @entity855 content, and the phagocytosis of PMNLs. @entity1 : 22 controls and 34 @entity1 with @entity2175 were examined. Fifteen @entity1 were studied before and after 3 months of treatment with @entity5217 . RESULTS: Polymorphonuclear leukocytes from @entity1 with @entity2175 showed significantly elevated basal levels of [ @entity141 ]i (68 +/- 9.6 compared with 43 +/- 4.9 nmol/L; P < 0.01); reduced @entity855 content (1.30 +/- 0.58 compared with 2.35 +/- 0.45 nmol/10(6) PMNLs; P < 0.01); and @entity73 (117 +/- 21.0 compared with 145 +/- 17.4 micrograms oil/10(7) PMNLs per minute; P < 0.01) compared with controls. There was a direct and significant correlation (P < 0.01, r = 0.80) between [ @entity141 ]i levels in PMNLs and serum @entity413 levels and an inverse correlation between phagocytic ability and [ @entity141 ]i levels (P < 0.01; r = 0.62) as well as between phagocytic activity and fasting serum @entity413 levels (P < 0.01, r = 0.54) in @entity1 with @entity2175 . @entity5217 therapy resulted in significant reduction in fasting serum @entity413 levels; in PMNLs, this treatment resulted in a significant reduction in [ @entity141 ]i levels, a significant increase in @entity855 content, and a significant improvement of phagocytosis. CONCLUSIONS: @entity1 with @entity2175 have elevated [ @entity141 ]i levels in PMNLs. This abnormality is probably induced by @entity4854 and is primarily responsible for the imparied phagocytosis seen in these @entity1 .
