A signature of aberrant immune responsiveness identifies @entity296 in XXXX .

@entity1 @entity650 @entity296 @entity712 @entity82 @entity5122 @entity2357 @entity204 @entity309 @entity1002
OBJECTIVE: @entity712 is an important cause of @entity204 in @entity1 with @entity309 ( @entity309 ). Evidence suggests that immune mechanisms contribute to @entity296 and @entity82 , leading to @entity1002 ( @entity1002 ). The purpose of this study was to identify a signature of @entity1002 in @entity1 with @entity309 by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: @entity309 @entity1 (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild @entity1002 , or moderate-to-severe @entity1002 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. @entity2357 models were used to test for associations between a multicytokine immune response score and @entity1002 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated @entity1 with moderate-to-severe @entity1002 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe @entity1002 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum @entity650 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other @entity309 characteristics and @entity1002 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced @entity296 in @entity1 with @entity309 . The unique information added by the immune response score concerning the likelihood of @entity1002 warrants future longitudinal studies of its value in predicting @entity5122 in myocardial function.
