XXXX -induced changes in place cell physiology: relationship to spatial memory.

@entity227 @entity410 @entity1249 @entity73 @entity16 @entity35 @entity2414 @entity159
@entity159 ( @entity159 ) is a frequent @entity16 associated with a significant risk of morbidity in survivors. Impairment of hippocampal-specific memory is a common and serious deficit occurring in many of the survivors. However, the pathophysiological basis of @entity73 after @entity159 is not clear. To directly address the cellular concomitants of spatial @entity2414 , we recorded the activity of place cells from @entity1249 in freely moving @entity35 subjected to @entity159 during early development and compared this activity to that in control @entity35 . Place cells discharge rapidly only when the @entity35 's head is in a cell-specific part of the environment called the "firing field." This firing field remains stable over time. Normal place cell function seems to be essential for stable spatial memory for the environment. We, therefore, compared place cell firing patterns with @entity227 in the water maze in @entity159 and control @entity35 . Compared with controls, place cells from the @entity159 @entity35 were less precise and less stable. Concordantly, the water maze performance was also impaired. There was a close relationship between precision and stability of place cells and water maze performance. In contrast, a single, acute, chemically induced @entity410 produced cessation of place cell activity and spatial @entity2414 in water maze performance that reversed within 24 hr. These results strongly bolster the idea that there is a relationship between abnormal place cells and spatial memory. Our findings also suggest that the defects in place cell and spatial memory after @entity159 and acute chemically induced @entity410 result from different processes.
