Histological and mechanical differences in the skin of XXXX with @entity3577 .

@entity1 @entity3577 @entity2362 @entity10038
INTRODUCTION: It is still an enigma that some @entity1 develop @entity3577 whilst others with similar risk factors do not. Biomechanical assessment of the skin may provide further insight into the aetiology of this complex condition. @entity2362 fibres are an abundant and integral part of many extracellular matrices and are especially critical for providing the property of elastic recoil to tissues. The significance of @entity2362 fibres is clearly reflected by the numerous @entity1 conditions in which a skin phenotype occurs as a result of @entity2362 fibre abnormalities. METHOD: Between January and June 2013, skin specimens were obtained prospectively during surgery on 20 @entity1 with @entity3577 and 21 @entity1 without prolapse undergoing surgery for other indications. Expression levels of @entity2362 in the skin were measured by @entity10038 staining, and Image J. Tensile tests were performed using the Zwick Roell device, with custom ceramic clamps. For statistical analysis, Student's t test was used. RESULTS: Histological analysis of prolapse vs control showed percentage dermal @entity2362 fibres of 9 vs 5.8  % (p   =   0.001) in males and 6.5 vs 5.3  % (p   =   0.05) in females. @entity1 with more severe prolapse (external) had a significantly (p   =   0.05) higher percentage dermal @entity2362 fibres 6.9 vs 6.1  % than internal prolapse. Young's modulus of @entity1 with prolapse was lower in males (3.3 vs 2.8, p   =   0.05) and females (3.1 vs 2.7, p   =   0.05). CONCLUSION: @entity1 with prolapse have a higher concentration of @entity2362 fibres in the skin, and these differences are quantitatively demonstrated through mechanical testing. This suggests that the aetiology may be a result of a dysfunction of @entity2362 fibre assembly.
