Temperature and serum proinflammatory cytokine changes in XXXX with NSCLC after BAL.

@entity1 @entity650 @entity1356 @entity310 @entity2
We examined the effects of bronchoalveolar lavage (BAL) and BAL fluid characteristics on the systemic proinflammatory cytokine expression and their relation to clinical and laboratory findings. Thirty @entity1 suspected to have @entity2 were subjected to fiber-optic bronchoscopy (FOB) and BAL. Clinical and laboratory findings were determined at baseline, 4 h, and 24 h, including lung auscultation, temperature, chest X-ray, WBC, neutrophils, and serum @entity1356 , @entity650 , and @entity310 . BAL fluid characteristics were determined including cytokine levels. Fifteen volunteers served as controls to determine serum variation of the same cytokines. Significant temperature elevation was defined as 1 degrees C increase compared to baseline. BAL was associated with temperature and serum @entity310 and @entity650 but not @entity1356 increase at 4 h. Four @entity1 (13.3%) developed temperature over 38 degrees C. In controls there were no significant changes between baseline and 24 h measurements for the same cytokines. Eleven @entity1 (36.6%) developed a significant temperature elevation 4 h after BAL. These @entity1 had a statistically significant ( p < 0.05) increase in serum @entity650 at 4 h and in @entity310 at both 4 and 24 h after BAL compared with the nonsignificant temperature increase group. BAL characteristics were not different between the two groups. On the other hand, BAL fluid @entity650 and @entity310 levels were significantly higher ( p < 0.05) in the nonfever group. Significant temperature increase was observed in 36.6% of the @entity1 undergoing BAL and associated with significant serum @entity310 and @entity650 increase at 4 h. Lung cytokines levels, alveolar macrophages, and BAL fluid characteristics are not related to temperature and serum proinflammatory cytokine increase. The hypothesis of alveolar macrophages derive from cytokine production and shift to the systemic circulation cannot be supported by our data.
