Neuroleptic-induced XXXX associated with amelioration of @entity716 in schizophrenia.

@entity1 @entity1088 @entity47666 @entity935 @entity3826 @entity716 @entity1767 @entity2332
Body temperature is a regulatory function of the hypothalamus. Recently, DeMet et al. (Society for Neuroscience Abstracts Vol 12, 1986) reported that @entity3826 stimulation of @entity935 autoreceptors caused a significant decrease in metabolic rate in the posterior heat-conserving area of the hypothalamus. The logical hypothesis to follow is that @entity3826 administration should induce a decrement in body temperature; this in fact was demonstrated by Cutler et al. (Commun Psychopharmacol 3:375-382, 1979) in @entity1 . It is well known that neuroleptics also disrupt thermoregulation (Clark: Neurosci Biobehav @entity47666 :179-231, 1979) and affect @entity935 autoreceptors. Therefore, eight chronic treatment-resistant schizophrenics underwent a 6-week single-blind trial of @entity1767 and then a subsequent 6-week double-blind trial of @entity1088 . Both @entity1767 and @entity1088 significantly lowered oral body temperatures relative to baseline washout temperatures. More interestingly, @entity1088 relative to @entity1767 was found to induce a greater decrement in body temperature and was associated with greater clinical improvement. Possible confounding variables are discussed, as is the possible neurochemical basis for the amelioration of @entity716 associated with @entity2332 .
