Features of Late Recurrence Following Transanal Local Excision for Early XXXX .

@entity1 @entity2558 @entity5 @entity75 @entity3
BACKGROUND: Transanal local excision has recently received attention as an alternative to radical surgery for early @entity5 . Recurrence usually occurs within 5 years after surgery, but recurrences later than this have also been reported. OBJECTIVE: The aim of this study was to investigate the incidence and risk factors of recurrence in @entity1 who have early @entity5 10 years after transanal local excision. DESIGN: @entity1 with early @entity5 who underwent transanal local excision from October 1994 to December 2010 were retrospectively reviewed. We reviewed the demographics and clinicopathologic features of primary lesions and analyzed the incidence and risk factors of recurrence. SETTINGS: This investigation was conducted at a tertiary university hospital. @entity1 : A total of 295 @entity1 who underwent transanal local excision for pTis (n = 155) or @entity2558 (n = 140) early @entity5 were included in the analysis. INTERVENTION: Transanal local excision was performed for each @entity1 to excise primary @entity75 . MAIN OUTCOME MEASURES: The primary end point of this study was the incidence of recurrence, especially late recurrence. The secondary end point was risk factors for recurrence. RESULTS: The 10-year cumulative local recurrence rate was 6.7% in pTis and 18.0% in @entity2558 @entity1 . The rate of late local recurrence was 2.8% in pTis and 3.7% in @entity2558 @entity1 . There was no evidence of late systemic recurrence 5 years after transanal local excision. In @entity2558 @entity1 , a higher risk of recurrence was associated with an invasion depth of sm3, the presence of @entity3 , and a positive resection margin. LIMITATION: The main limitation of this study is its retrospective nature. CONCLUSIONS: Late recurrence can occur in @entity1 with early @entity5 who have undergone transanal local excision. Transanal local excision can be performed in selective @entity1 with biologically favorable @entity5 , and 10-year postoperative surveillance should be considered for these @entity1 .
