Differentiated clinical presentation of early and late-onset XXXX : is 65  years of age providing a reliable threshold?

@entity1 @entity527 @entity73 @entity409 @entity3072 @entity2526 @entity195
Early-onset and late-onset @entity195 (EOAD and LOAD) are two forms of the disease with the same characteristic neuropathological hallmarks. However, higher burdens of @entity527 and @entity3072 in frontal and parietal lobes have been found in EOAD than in LOAD @entity1 . Thus, the EOAD subjects may have a differentiated clinical presentation compared to the LOAD ones. Some authors have found less hippocampal memory presentations and more focal @entity2526 (such as @entity409 ) in EOAD than LOAD @entity1 . The aim of the present study was to determine which initial clinical profiles differ between EOAD and LOAD; and to analyze whether another age cut-off could discriminate better between EOAD and LOAD clinical presentations than the conventional limit of 65. All @entity1 fulfilling NINCDS-ADRDA criteria for probable @entity195 who referred to our Hospital between October 2007 and December 2012 were included in the study. The conventional age limit of 65 was established to distinguish between EOAD and LOAD. Baseline neuropsychological scores, adjusted for age and education, were compared between both groups. A total of 181 @entity1 (38 EOAD, 143 LOAD) entered in the analysis. Sex distribution and time of evolution of symptoms did not differ between groups. The EOAD @entity1 performed worse than LOAD in attentional, imitation praxis and verbal learning tests. In addition, the age cut-off of 70 was found to differentiate between early- and late-onset groups better than the standard cut-off of 65  years old. Our results support a differentiated @entity73 pattern in EOAD compared to LOAD.
