Anti-nociceptive activity of the crude extract of Myrianthus arboreus P. Beauv (Cecropiaceae) in XXXX .

@entity137 @entity19 @entity406 @entity615 @entity158 @entity1543
ETHNOPHARMACOLOGICAL RELEVANCE: Myrianthus arboreus P. Beauv (Cecropiaceae) is a shrub or a tree plant widely distributed in Tropical Africa. In the South Eastern part of Nigeria, the leaves are used in traditional medicine as an analgesic for muscular @entity158 , and also as an enema to relieve @entity615 . Although no scientific study has been performed to validate its traditional use in @entity158 management, this study therefore aims at investigating the anti-nociceptive activity of M. arboreus leaves extract in @entity19 . MATERIALS AND METHODS: Anti-nociceptive activity of M. arboreus was investigated using @entity1543 induced writhing, @entity406 induced paw licks, hot plate, and tail flick tests. Acute @entity137 was determined using a slightly modified Lorkes method. RESULTS: The extract of M. arboreus produced a significant dose-dependent [F (4, 20)=13.48 p<0.001] inhibition of abdominal writhings induced by @entity1543 . In the @entity406 paw licking test, it produced a significant dose-dependent inhibition of neurogenic and inflammatory @entity158 [F (4, 17.5)=60.13 p<0.001]. It also produced a significant dose dependent [F (4, 20)=30.5 p<0.001; F (4, 20)=0.321 p<0.0001] prolongation of the latency and reaction time in the hot plate and tail immersion tests. Peak effect was observed at the highest dose (40mg/kg). LD50 of the plant was found to be 894mg/kg. CONCLUSION: M. arboreus possesses potent antinociceptive activity mediated centrally and peripherally, an effect which may justify its traditional use in the management of @entity158 .
