[Treatment of acute XXXX with intraperitoneal @entity7048 ].

@entity1 @entity801 @entity7048 @entity868 @entity698 @entity2890 @entity6177 @entity1661 @entity733 @entity8899 @entity298 @entity3402
Until recently intra- @entity1661 following surgery for @entity698 has remained a frequent occurrence. In 1975 Fowler reported an incidence of one @entity6177 in 36 @entity698 treated with a protocol consisting of saline irrigation at surgery, followed by intraperitoneal administration of @entity8899 q. 6 hours for 48 hours. The same antibiotic was then given i.v. for 72 hours. He concluded that this method was an effective way to minimize post-op @entity6177 , and that the intraperitoneal route was more effective, for this purpose, than systemic administration. More recently, with better knowledge of the role of anaerobes, improved results have also been obtained by adding @entity3402 or @entity868 to the antibiotic regimen. A prospective study based on two groups of @entity1 randomly assigned to two protocols was undertaken. The study group consisted of 45 @entity1 operated for @entity698 with @entity733 or generalized @entity298 . These @entity1 were treated with Fowler's protocol. Because it is less nephrotoxic and is active against the same organisms, @entity7048 was used instead of @entity8899 . The control group consisted of 43 @entity1 , also operated for @entity698 , treated with saline irrigation at surgery, with either i.v. @entity801 or @entity2890 and @entity3402 or @entity868 for an average of 7.8 +/- 3.1 days. Both groups were fairly well matched in terms of age, sex, severity of disease, and bacterial flora. They showed an identical 6% post-op intra- @entity1661 rate. Days before afebrile, days under gastric suction, complications and average hospital stay were comparable in both groups. The wound infection rate was 20% in the study group and 9% in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)
