Profilins: mimickers of XXXX or relevant allergens?

@entity1 @entity2023 @entity2487 @entity566 @entity523 @entity56 @entity1576
Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems to arise from pollen sensitization with later development of cross-reactive IgE antibodies against plant food (and possibly latex) profilins. The role of profilin in inducing @entity56 needs to be evaluated and raises important issues in @entity566 diagnosis due to cross-reactivity. IgE cross-reactivity among profilins is associated with multiple pollen sensitization and with various @entity2023 . In @entity1576 , sensitization to pollen to which the @entity1 has virtually no environmental exposure has been identified as a manifestation of profilin sensitization. As a food allergen, profilin usually elicits mild reactions, such as @entity566 , is not modified by processing and is especially important in @entity566 to some fruits, such as @entity2487 , watermelon, banana, @entity523 , citrus fruit and persimmon. Purified natural and recombinant profilins for in vitro and in vivo @entity566 tests are helpful in the diagnostic work-up. Herein we review the current state of knowledge about the allergen profilin and its implications in the diagnosis and treatment of @entity56 . We conclude that, although its role in triggering @entity56 is still controversial, profilin is undoubtedly a relevant allergen. As a pan-allergen, profilin is associated with multiple pollen sensitization and pollen-food-latex syndromes that the allergist has to be aware of in order to accomplish an accurate diagnosis and successful treatment of @entity56 .
