Endogenous @entity6026 Regulates Testicular Germ Cell Apoptosis during XXXX .

@entity32 @entity295 @entity5694 @entity6026 @entity19 @entity4 @entity185 @entity11570 @entity204
UNASSIGNED: @entity11570 ( @entity4 ) often occurs during systemic inflammatory conditions, such as @entity295 . @entity6026 is a proinflammatory cytokine and is an apoptotic mediator during @entity5694 , but the role of @entity6026 in response to @entity32 in the testes was unclear. Wild type and @entity6026 knockout (KO) @entity19 were injected lipopolysaccharide (LPS) to induce @entity5694 and examined 12 and 48 hours after LPS administration to model the acute and recovery phases of @entity5694 . Caspase activation was assessed using immunohistochemistry. Protein and mRNA expression were examined by western blot and quantitative reverse-transcriptase, real-time PCR, respectively. During the acute phase of @entity5694 , apoptosis (as indicated by @entity185 cleavage) was increased in WT @entity19 but not in @entity6026 KO @entity19 . The @entity204 receptor-mediated and mitochondrial-mediated apoptotic pathways were both activated in the WT @entity19 but not in the KO @entity19 . During the recovery phase of @entity5694 , apoptosis was observed in the @entity6026 KO @entity19 but not in the WT @entity19 . Activation of the @entity204 -receptor mediated apoptotic pathway could be seen in the @entity6026 KO @entity19 but not the WT @entity19 . These results suggested that endogenous @entity6026 induces germ cell apoptosis via @entity204 receptor mediated- and mitochondrial-mediated pathways during the acute phase of @entity5694 and suppresses germ cell apoptosis via @entity204 -receptor mediated pathways during recovery from @entity5694 . Taken together, @entity6026 could be a new therapeutic target to prevent @entity11570 during @entity5694 .
