Tracheal Self-Expandable Metallic Stents: A Comparative Study of Three Different Stents in a XXXX Model.

@entity738 @entity19926 @entity95 @entity26988 @entity850 @entity5648
INTRODUCTION: The objective of this study was to assess tracheal reactivity after the deployment of different self-expandable metal stents (SEMS). MATERIAL AND METHODS: Forty female @entity95 were divided into four groups. Three groups received three different SEMS: steel (ST), @entity5648 ( @entity26988 ), or @entity5648 drug-eluting stent (DES); the fourth group was the control group (no stent). Stents were deployed percutaneously under fluoroscopic guidance. Animals were assessed by multi-slice, computed tomography (CT) scans, and tracheas were collected for anatomical pathology (AP) study. Data from CT and AP were statistically analyzed and correlated. RESULTS: The DES group had the longest @entity850 (20.51  14.08mm vs. 5.84  12.43 and 6.57  6.54mm in @entity26988 and ST, respectively, day 30; P<.05), and higher @entity738 formation on CT (50% of cases). The @entity26988 group showed the lowest grade of @entity850 (2.86  6.91% vs. 11.28  13.98 and 15.54  25.95% in DES and ST, respectively; P<.05). The AP study revealed that the ST group developed intense proliferative reactivity compared to the other groups. In the DES group, a destructive response was observed in 70% of the animals, while the @entity26988 was the least reactive stent. CT was more effective in detecting wall thickening (positive correlation of 68.9%; P<.001) than @entity738 (not significant). CONCLUSIONS: The ST group developed @entity738 and significant @entity850 . @entity26988 was the least reactive stent, while DES caused significant lesions that may be related to drug dosage. This type of DES stent is therefore not recommended for the treatment of @entity19926 .
