Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in XXXX with @entity157 .

@entity1 @entity70696 @entity5 @entity65466 @entity70697 @entity1350 @entity70695 @entity160 @entity3 @entity33810 @entity157 @entity204
BACKGROUND: Recurrent chromosome 20q gain is implicated in progressive @entity5 and has been associated with clinical outcomes in multiple types of @entity5 ; however, its prognostic significance in @entity157 ( @entity157 ) and the involved genes remain unclear. METHODS: Array comparative genomic hybridization and expression arrays were used to detect copy number alterations (CNAs) and expression levels, respectively. The associations between CNAs in 20q and outcomes were analyzed on 66 @entity1 , for which the follow-up period was 2.6-73.3  months. One hundred seventeen @entity5 were further investigated to identify target genes in the potentially outcome-related CNAs. RESULTS: Regional or whole 20q gain was detected in 24 (36.4  %) of the 66 @entity157 cases. The most recurrent gains were 20q11.21-12, 20q12-13.12, 20q13.12-13.33 and 20q13.33. Of the CNAs, 20q13.12-13.33 gain was significantly associated with reduced extrohepatic @entity3 -free and overall survival, as well as with elevated postoperative @entity160 level, @entity5 @entity1350 and advanced @entity5 stage. Multivariate Cox analysis identified 20q13.12-13.33 gain as an independent prognostic marker for @entity3 (HR 3.73, 95  % CI 1.08-12.87) and @entity204 (HR 3.00, 95  % CI 1.26-7.13). A panel of 19 genes in 20q13.12-13.33 was significantly overexpressed in HCCs with gain compared to HCCs without. High expression (greater than median) for 5 of the 19 genes, @entity70695 , @entity33810 , @entity70696 , @entity70697 and @entity65466 , correlated significantly with @entity1350 , and high @entity70696 expression also with advanced @entity5 stage. CONCLUSIONS: Gain at 20q13.12-13.33 is a prognostic marker of @entity3 and @entity204 , and @entity70695 , @entity33810 , @entity70696 , @entity70697 , and @entity65466 are probable target genes which may be involved together in the unfavorable outcomes of @entity157 @entity1 .
