Clinical utility of capsule endoscopy with flexible spectral imaging color enhancement for diagnosis of XXXX .

@entity1 @entity455 @entity1127 @entity2681 @entity5 @entity29
UNASSIGNED: Background and study aims: The clinical utility of computed virtual chromoendoscopy with flexible spectral imaging color enhancement (FICE) in capsule endoscopy (CE) remains controversial. To clarify the clinical utility of FICE-enhanced CE in evaluating @entity29 , we quantitatively assessed white light (WL), FICE, and blue mode (BM) images and examined the sensitivity of these 3 imaging modes of small-bowel lesions from @entity1 who underwent CE. Methods: The CIELAB color difference (   E) and visual analogue scales (VAS) were measured in 261CE images (3 different lesion categories) using WL and FICE set 1, 2, and 3, and BM images, respectively. Three endoscopists reviewed CE videos with WL, 3 FICE mode settings, and BM, and compared the sensitivity and detectability for small intestinal diseases from 50 @entity1 who underwent CE. Results: In the assessment of visibility in the 152 vascular lesion images, the    E and VAS of FICE set 1, 2, and BM images were significantly higher than that of WL images. In 88 @entity2681 /ulceration images, the    E and VAS of FICE set 1 and 2 images were significantly higher than that of WL images. In 21 @entity5 images, there were no significant differences in    E among these modalities. When analyzed on a per- @entity1 basis, FICE settings 1 and 2 had the highest sensitivity (100%) and specificity (97.3-100%) for @entity455 . As for erosive/ulcerative lesions, FICE setting 2 had the highest sensitivity (100%) and specificity (97.2%). For @entity5 or @entity1127 , WL had the highest sensitivity (90.9%) and specificity (87.1%). In per-lesion analysis, FICE settings 1 and 2 showed significantly superior detection ability over WL for @entity455 . In the detection of erosive/ulcerative lesions, FICE setting 2 was significantly superior to WL. In @entity5 images, there was no significant improvement with any of the settings relative to WL images. Conclusions: FICE is most useful for improving CE image quality and detection in cases of angioectasia and @entity2681 /ulceration of the small intestine.
