Differences in the EEG profiles of early and late responders to antipsychotic treatment in first-episode, drug-naive psychotic XXXX .

@entity1 @entity161 @entity914 @entity2263
The aim of this study was to search for differences in the EEG of first-episode, drug-naive @entity1 having a @entity161 which presented different time courses in response to antipsychotic treatment. Thirteen @entity1 who fulfilled DSM-IV diagnosis for @entity161 or @entity914 participated in this study. Before beginning antipsychotic treatment, the EEG was recorded. On the same day psychopathological ratings were assessed using the ADMDP system, and again after 7 and 28 days of treatment. The resting EEG (19 leads) was subject to spectral analysis involving power values for six frequency bands. The score for the @entity161 was used to divide the @entity1 into two groups: those who displayed a clinically meaningful improvement of this syndrome (reduction of more than 30%) after 7 days of treatment (early responders, ER) and those who showed this improvement after 28 days (late responders. LR). Analysis of variance for repeated measures between ER, LR and their matched controls with the 19 EEG leads yielded highly significant differences for the factor group in the alpha2 and @entity2263 frequency band. No difference was found between the slow-wave frequency bands. Compared to controls the LR group showed significantly higher alpha2 and @entity2263 power and, in comparison to the ER group, significantly higher alpha2 power. There were no significant differences between the ER and the control group. These findings point to differences in brain physiology between ER and LR. The implications for diagnosis and treatment are discussed.
