Effects of acute doses of ethanol administered at pre-implantation stages on fetal development in the XXXX .

@entity851 @entity167 @entity19 @entity3002 @entity1592 @entity3571 @entity5617
The objective of the present study was to investigate the effects of maternal administration of acute doses of @entity167 at preimplantation stages of pregnancy on the fetus and fetal membranes. Single doses of 0.02 ml and 0.03 ml/g body wt. of 25% v/v of absolute @entity167 in saline were administered to groups of @entity3571 @entity19 on one of days 1-6 of gestation. Controls were either pair-fed and pair-watered or saline-treated. Fetuses and placentae were collected on day 15. Resorption and @entity5617 were increased in most of the @entity167 treatment groups. The reduction in fetal body weight was significant in the 0.03 ml group. Compared to the saline controls, most experimental groups exhibited a rise in placental weight. The reduction in cord length was significant in comparison to untreated controls. Craniofacial and @entity3002 appeared to correlate with retardation of fetal growth. Hence, following treatment of 0.03 ml/g body wt. of @entity167 solution on days 2 and 6, fetuses were collected on days 14, 16 and 18. Most fetuses were found to recover gradually from anomalies associated with @entity851 but the 'catch up' growth was not adequate enough to compensate for the reduction in body weight. These observations indicate that the pre-implantation stage of @entity19 embryo development is susceptible to the deleterious effects ( @entity5617 and @entity1592 ) of acute doses of @entity167 .
