Osteoblast inhibition by chemokine cytokine ligand3 in XXXX -induced @entity79 .

@entity1 @entity8088 @entity8087 @entity12502 @entity16951 @entity1582 @entity79 @entity1583 @entity460 @entity10557
BACKGROUND: @entity1582 is a @entity1583 characterized by the accumulation of monoclonal plasma cells in the bone marrow. A common manifestation of the disease is @entity79 ( @entity79 ), which is caused by @entity79 and decreased bone formation. The @entity10557 ( @entity10557 ) is a pro-inflammatory protein and chemokine that stimulates osteoclasts in @entity79 . However, little is known about the effect of @entity10557 on osteoblasts (OB). METHODS: The OBs are induced from @entity1 with @entity79 and healthy donors, cultured in vitro, and identified by histochemistry. The effects of @entity10557 and @entity10557 antibody on the OBs in vitro are observed. The @entity10557 receptor ( @entity16951 ), @entity12502 ( @entity12502 ), @entity8087 ( @entity8087 ), and @entity8088 ( @entity8088 ) are detected using flow cytometry, enzyme-linked immunosorbent assay, and real-time PCR. RESULTS: Proliferation and osteogenic potential of the OB in @entity1 with @entity79 are suppressed. Moreover, the @entity16951 expression is significantly higher in @entity1 with @entity79 than in normal controls. The @entity12502 level, quantity of @entity460 nodules, and @entity8087 and @entity8088 levels decrease after @entity10557 stimulation, which indicates that @entity10557 inhibits OB function. Furthermore, @entity10557 antibody partially restores OB activity through the upregulation of the @entity12502 , @entity8087 , and @entity8088 . CONCLUSIONS: @entity10557 contributes to the OB/OC imbalance by inhibiting OB differentiation and function in @entity79 .
