Dysfunctional mitochondrial bioenergetics and the pathogenesis of XXXX .

@entity1 @entity1522 @entity99 @entity137 @entity96 @entity26 @entity409 @entity1718 @entity413 @entity855
The liver is involved in a variety of critical biological functions including the homeostasis of @entity413 , @entity1718 , @entity1522 , and the synthesis of proteins that are secreted in the blood. It is also at the forefront in the detoxification of noxious metabolites that would otherwise upset the functioning of the body. As such, this vital component of the @entity1 system is exposed to a notable quantity of toxicants on a regular basis. It therefore comes as no surprise that there are over a hundred disparate @entity99 , encompassing such afflictions as @entity409 , @entity99 , and @entity96 . Most if not all of liver functions are dependent on energy, an ingredient that is primarily generated by the mitochondrion, the power house of all cells. This organelle is indispensable in providing @entity855 ( @entity855 ), a key effector of most biological processes. Dysfunctional mitochondria lead to a shortage in @entity855 , the leakage of deleterious reactive @entity26 species (ROS), and the excessive storage of fats. Here we examine how incapacitated mitochondrial bioenergetics triggers the pathogenesis of various @entity99 . Exposure of liver cells to detrimental environmental hazards such as oxidative stress, @entity137 , and various xenobiotics results in the inactivation of crucial mitochondrial enzymes and decreased @entity855 levels. The contribution of the latter to @entity99 and potential therapeutic cues to remedy these conditions are elaborated.
