Statin Use and Serum Lipid Levels are Associated with Survival Outcomes after Surgery for XXXX .

@entity1 @entity3012 @entity1674 @entity1358 @entity412 @entity1349
OBJECTIVE: To evaluate the association of statin use and pre-operative serum lipid parameters with oncologic outcomes following surgery for @entity1358 ( @entity1358 ). METHODS: 850 @entity1 who underwent surgery for localized @entity1358 at our institution from 2000-2012 were included. Use of statins, preoperative serum lipid profile and comprehensive clinicopathologic features were retrospectively recorded. Kaplan Meier analysis and multivariate Cox proportional hazards model were employed to compare survival outcomes. RESULTS: There were 342 statin users and 508 non-users. Median follow-up was 25.0 months. Statin users were older, had greater body mass index and worse performance status than non-users. Tumor pathologic characteristics were balanced between groups. 5-year @entity1349 ( @entity1349 ) was 77.9% for non-users compared to 87.6% for statin users (p=0.004). After adjustment for clinicopathologic variables, statin use was independently associated with improved @entity1349 (HR 0.54, 95%CI 0.33-0.86, p=0.011) and @entity3012 (HR 0.45, 95%CI 0.28-0.71, p=0.001). In @entity1 with available serum lipid parameters (n=193), 5-year @entity1349 was 83.8% for @entity1 with TG<250 mg/dL compared to 33.3% for those with TG>250 mg/dL (p<0.0001). Elevated serum @entity1674 (>250mg/dl) was independently associated with worse @entity1349 (HR 2.69, 95%CI 1.22-5.93, p=0.015) on multivariate analysis. CONCLUSIONS: Statin use was independently associated with improved survival, while elevated serum @entity412 levels correlated with worse oncologic outcomes in this cohort. These findings warrant validation in prospective studies.
