[Preoperative serum a-1-fucosidase as an early-recurrent indicator for XXXX following curative resection].

@entity1 @entity157 @entity5
OBJECTIVE: To investigate the early-recurrence prediction value of preoperative alpha-1-fucosidase (AFU) for @entity157 ( @entity157 ) @entity1 undergoing curative resection. METHODS: A retrospective training set data from January to July, 2012 including 116 @entity1 and a prospective validation set from August 2012 to December 2012 including 68 @entity1 were used to validate the predictive value of preoperative AFU. Difference of recurrence rates between low and high AFU populations in all @entity157 or early- @entity157 subgroups were compared via Kaplan-Meier curves and Log-rank tests. Univariate and multivariate analyses were used to identify the recurrent prediction value of preoperative serum AFU. RESULTS: Based on retrospective training data, AFU = 25.00 U/L was set as the optimal cutoff point to stratify @entity157 @entity1 into high (>25.00 U/L) and low (  <= 25.00 U/L) groups. @entity1 with high preoperative AFU showed significant low @entity5 -free survival not only in whole @entity1 group (mean 12.50 months vs.not reached; P < 0.01) but also in early- @entity157 (mean 10.25 months vs.not reached, P < 0.01) and AFP negative subgroups (mean 13.20 months vs not reached, P < 0.01). Univariate and multivariate analyses revealed the AFU was an independent predictor for @entity5 recurrence (OR = 1.72, 95%CI:1.00-2.96, P = 0.04). The prospective validation data confirmed the predictive value of preoperative AFU in @entity157 (OR = 2.22, 95%CI:0.67-7.37, P = 0.04). Furthermore, @entity1 with high preoperative AFU were prone to have bigger @entity5 and form vascular invasion. CONCLUSION: Preoperative AFU is a powerful prognostic indicator for @entity157 and 25.00 U/L might be an optimal recurrence prediction cutoff value for @entity1 in Zhongshan hospital.
