Persistent disease after surgery for XXXX : the long-term outcome.

@entity1 @entity459 @entity174 @entity460 @entity1011 @entity2742 @entity65
OBJECTIVE: Nineteen @entity1 with persistent @entity459 were investigated to evaluate their clinical and laboratory status a long time after treatment was ended. The risk of persistent disease and need for extensive surgery for cure, i.e. more than two neck operations, or mediastinal exploration, was also evaluated. DESIGN: The medical records of 896 consecutive @entity1 operated on for @entity459 were scrutinised at follow-up, a mean of 10.3 Years after surgery. Data on state of health, medication, @entity174 and other diagnoses were collected by use of a questionnaire. There were 600 @entity1 still alive, among whom 13 had persistent disease and they were compared with 509 @entity1 who were cured and without any suspicion of recurrent disease, according to laboratory examination. RESULTS: Serum @entity460 and @entity1011 values had with few exceptions remained stable over the Years. In five patients, serum @entity460 levels were within the normal range at follow-up. Still, all 19 @entity1 were considered @entity2742 . They had substantial @entity65 , and their state of health was not as good as that of the @entity1 who were surgically cured. After one operation, 5.5% (95% confidence interval (CI) 4.0-7.2%) had persistent disease, and 2.1% after reoperation. Extensive surgery for cure was performed in 2% of the @entity1 (95% CI 1.1-3.2%). CONCLUSIONS: We found that the state of health was significantly better for @entity1 with cured @entity459 than for @entity1 with persistent disease, but serious deterioration of laboratory values was uncommon. The result of the present study supports surgical treatment.
