Embryonic karyotype of abortuses in relation to the number of previous XXXX .

@entity1 @entity2008 @entity2208
OBJECTIVE: To examine the frequency of @entity2008 in products of conception from @entity1 with recurrent @entity2208 in relation to the number of previous @entity2208 . DESIGN: Retrospective analysis. SETTING: Nagoya City University Medical Hospital. @entity1 (S): A total of 1,309 @entity1 with a history of 2-20 consecutive first-trimester abortions. INTERVENTION(S): Chromosomal analysis performed on products of conception with use of a standard G-banding technique. MAIN OUTCOME MEASURE(S): The frequencies of abnormal and normal embryonic karyotypes for each number of previous abortions were studied. The subsequent pregnancy outcome of @entity1 whose previous @entity2208 were karyotyped were studied along with the predictive value of karyotyping of previous @entity2208 for subsequent @entity2208 . RESULT(S): The miscarriage rate increased with the number of previous @entity2208 . The frequency of abnormal embryonic karyotypes significantly decreased and that of normal embryonic karyotypes significantly increased with the number of previous abortions. Among 71 @entity1 whose embryonic karyotypes were normal, 44 aborted subsequently, and 23 of 60 @entity1 whose embryonic karyotypes were abnormal aborted subsequently. @entity1 with a previous normal embryonic karyotype aborted more frequently than those with an abnormal karyotype. CONCLUSION(S): The frequency of normal embryonic karyotypes significantly increases with the number of previous abortions, and a normal karyotype in a previous pregnancy is a predictor of subsequent miscarriage.
