Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in XXXX .

@entity5230 @entity16538 @entity12698 @entity19 @entity15484 @entity15792 @entity2359
UNASSIGNED: Cyclooxygenase (COX) enzymes are expressed in the brain; however, their role in hippocampus-dependent and cortex-dependent cognitive functions remains to be fully elucidated. The aim of the present study was to comparatively investigate the effects of @entity5230 , a selective @entity16538 inhibitor, and @entity12698 , a selective COX  -II inhibitor, on cognitive functions in an @entity15484  -induced @entity2359 @entity19 model to understand the specific role of each COX enzyme in the hippocampus and cortex. The @entity15484 (250  mg/kg) was administered to the @entity19 in drinking water and the drugs were administered in feed for 30  days. Assessments of memory, including a Morris water maze, social behavior and nesting behavior were performed in control and treated @entity19 . The RNA expression of the COX enzymes were analyzed using reverse transcription  -quantitative polymerase chain reaction analysis. An ex  -vivo @entity15792 assay was performed in the hippocampus and cortex. Following 30  days of treatment with thedrugs, the @entity19 in the @entity12698  - and @entity5230  -treated groups exhibited enhanced learning (6.84  0.76 and 9.20  1.08, respectively), compared with the @entity15484  -induced @entity2359 group (21.14  0.76) on the fifth  day of the Morris water maze test. @entity12698 treatment improved social affiliation in the @entity15484  -induced @entity2359 group, the results of which were superior to @entity5230 . @entity5230 led to better improvement in nesting score in the @entity15484  -induced @entity2359 group. Both drugs decreased the expression levels of @entity16538 and COX  -II in the hippocampus and cortex, and rescued oxidative stress levels. These findings suggested that each drug distinctly affected cognitive functions, highlighting the distinctive roles of @entity16538 and COX-II in learning and memory.
