Burden of Influenza-Related Hospitalizations and Attributable Mortality in Pediatric XXXX .

@entity1 @entity981 @entity204 @entity5
BACKGROUND: Influenza can be severe in @entity1 with underlying @entity5 ; however, the rate of influenza hospitalizations and attributable mortality in @entity1 with @entity5 is unknown. METHODS: We performed a retrospective cohort study among 10 698 @entity1 with new-onset @entity981 ( @entity981 ) from 41 US @entity1 's hospitals between January 1999 and September 2011. Influenza-related hospitalizations were identified using ICD-9 discharge diagnosis codes, excluding hospitalizations during low-prevalence influenza periods. Follow-up was censored at the earliest of 5 events: end of study period, expected end of chemotherapy, last known hospitalization, hematopoietic stem cell transplant, or @entity204 . Data were collected on hospitalization characteristics and resource utilization. Hospitalization rates were calculated using season-adjusted @entity1 -time. Crude attributable in-hospital mortality was calculated using baseline mortality for noninfluenza hospitalizations during the same period. Subgroup analysis was performed by time from @entity981 diagnosis and by age category. RESULTS: The rate of influenza-related hospitalizations was 618.3 per 100 000 @entity1 -months. Rates were similar by time from @entity981 diagnosis and across age categories. Overall attributable in-hospital mortality was 1.0% (95% confidence interval [CI], 0.3%-2.3%) and was highest for @entity1 <6 months from diagnosis (1.6%; 95% CI, 0.4%-4.5%) and @entity1 <2 years of age (6.7%; 95% CI, 1.3%-22.7%). Total length of stay, days of broad-spectrum antibiotic exposure, and duration of intensive care were significantly greater for influenza-related hospitalizations compared with noninfluenza hospitalizations. CONCLUSIONS: The burden of influenza-related hospitalizations in @entity1 with @entity981 is high and associated with significantly increased resource utilization and attributable mortality.
