The clinical pharmacology of XXXX in young adults and in elderly @entity1 .

@entity1 @entity4094 @entity26 @entity4490 @entity55753 @entity3810 @entity5161 @entity3575 @entity1339
@entity4094 induced by @entity55753 30 micrograms.kg-1 was compared in 21 young (18-55 years) and 17 elderly (65-85 years) @entity1 . Anaesthesia was induced with @entity4490 and maintained with @entity3575 , @entity3810 in @entity26 and @entity5161 . @entity4094 was measured electromyographically (Datex Relaxograph) at the adductor pollicis using train-of-four stimuli at 20 s intervals. The depth of maximum @entity4094 was similar in young and elderly @entity1 (median 100% compared to 96%). However, the onset was significantly slower in the elderly: their mean (SD) time to 90% suppression of the first response of the train-of-four was 7.7 (1.8) min compared to 5.7 (1.7) min in the young (p = 0.002). Four min after @entity55753 , the conditions for tracheal intubation were significantly poorer in the elderly (p < 0.001). Mean (SD) recovery of first response of the train-of-four to 25% of control was unaffected by age: young 79.0 (41.6) min; elderly 66.2 (32.1) min (p > 0.05). When the first response had reached 25% of control, @entity4094 was antagonised with @entity1339 60 micrograms.kg-1. The mean time to first response to 90% of control was similar in the young and the elderly @entity1 (9.1 min compared to 10.4 min). Recovery of the train-of-four ratio to 0.7 was significantly slower in the elderly: mean (SD) 17.1 (10.6) min compared to 10.1 (7.0) min (p = 0.03). @entity55753 was associated with clinically insignificant haemodynamic changes in both groups.
