White matter correlates of @entity73 after mild XXXX .

@entity1 @entity131 @entity17 @entity73 @entity62
OBJECTIVE: To relate neurophysiologic changes after mild/moderate @entity131 to @entity73 in a longitudinal diffusion tensor imaging investigation. METHODS: Fifty-three @entity1 were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three @entity1 were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, @entity1 completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance. RESULTS: Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting @entity17 , but still regressed negatively with Verbal Letter Fluency in the anterior forceps. CONCLUSIONS: Acute mild/moderate @entity131 is characterized by increased tissue FA, which represents a clear neurobiological link between @entity73 and @entity62 after mild/moderate injury.
