Evaluation of 4DryField   PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in XXXX .

@entity35 @entity1104 @entity130
BACKGROUND: Adhesions due to pelvic/abdominal surgery are a common serious pathology possibly entailing severe complications. This study investigates the adhesion prevention capability of the novel starch-based agent 4DryField   PH, which together with saline solution forms a barrier gel. Herein, an optimized adhesion model (OPAM) inducing severe @entity1104 /agglutinations with high reproducibility was used. METHODS: In 19 Lewis @entity35 , a 1 * 2 cm abdominal wall defect was created, the peritoneum of the neighboring cecum was abraded, and both injured areas were approximated by suture. @entity35 were randomized to control (n = 10) or 4DryField PH treatment (n = 9) groups. Another 8 @entity35 had sham surgery for safety assessment of 4DryField PH. At day 7, the quantity and quality of @entity1104 were assessed macro-/microscopically and evaluated statistically. RESULTS: 4DryField PH treatment significantly reduced the incidence and severity of @entity1104 as verified by significantly improved adhesion scorings (0.4 vs. 4.5; 1.1 vs. 9). Histology revealed reconstitution of the cecum and abdominal wall including regeneration of the visceral/parietal peritoneum. In sham-operated @entity35 , 4DryField PH did not induce adhesion formation. CONCLUSIONS: 4DryField PH gel was highly effective in preventing @entity1104 . Histologically, the injured cecum and abdominal wall regenerated well in the presence of 4DryField PH. Considering the severity of OPAM @entity130 , the potential of 4DryField PH to prevent @entity1104 can be rated excellent.
