Involvement of natural killer T cells and granulocytes in the XXXX induced by partial hepatectomy.

@entity32 @entity19 @entity1140 @entity99 @entity22873
BACKGROUND/AIMS: Natural killer T (NKT) cells are present in the liver of @entity19 . We examined whether NKT cells and other leukocytes were associated with @entity99 after partial hepatectomy. METHODS: Approximately 70% of the liver was removed from @entity19 using the method described by Higgins and Anderson. RESULTS: Partial hepatectomy induced the expansion of NKT cells in the liver and the elevation of transaminase. These responses were completely suppressed by the administration of @entity1140 . NKT cell-deficient @entity19 showed a decreased level of transaminase after partial hepatectomy. Perforin (-/-) @entity19 showed an elevation of transaminase while B6-gld/gld @entity19 (Fas ligand-) showed a decreased elevation of transaminase. In @entity22873 (-/-) @entity19 which lacked CD8+ cytotoxic T cells, @entity32 remained at a normal level after partial hepatectomy. Since NKT cell-deficient @entity19 showed up to 50% decrease in the level of @entity32 , we examined the association of other leukocytes with the remaining @entity32 . The number and proportion of granulocytes were increased by partial hepatectomy. CONCLUSIONS: Both NKT cells and granulocytes participated in the @entity99 after partial hepatectomy. The function of NKT cells, but not of granulocytes, was found to be sensitive to the immunosuppressive effect of @entity1140 .
