Nemaline rods in XXXX .

@entity1 @entity854 @entity2026 @entity354 @entity1282 @entity121 @entity130
@entity1282 , a disorder of uncertain pathogenesis, is most frequently found in @entity1 with associated @entity354 . Seven @entity1 who had dominant @entity1282 were evaluated. Manometry showed characteristic motor incoordination. Biochemical profiles and endoscopy were normal. Electronmicroscopic examination of the cricopharyngeal muscle biopsy specimens obtained during myotomy showed significant @entity854 . These included numerous and aberrant mitochondria, increased glycogen, lipid inclusions, and phagolysozomes. A striking finding was the presence of numerous nemaline rods in five of seven biopsy specimens examined. The pathologic changes in this muscle in cryopharyngeal @entity1282 have not been reported previously. Structural changes are thought to be a secondary response to @entity130 . Nemaline rods form part of the structural abnormality of muscle in @entity1 who have cricopharyngeal @entity2026 with no evidence of underlying generalized disease or @entity121 .
