Incidence of clinically diagnosed subtypes of XXXX in an elderly population. Cambridge Project for Later Life.

@entity1 @entity303 @entity1294 @entity73 @entity195
BACKGROUND: In developed countries, most @entity303 appears to be due to @entity195 and @entity1294 . We report rates for incidence of subtypes of @entity303 based on clinical diagnosis. METHOD: This study was a 2.4-year (s.d. 2.6 months) follow-up of a cohort aged 75 years and over, seen initially in a prevalence study of @entity303 . A screening interview in 1173 survivors was followed in a subsample of 461 respondents by a diagnostic interview 1.8 months after screening (s.d. 1.5 months). This comprised a standardised interview with respondent and informant, with venepuncture where possible. Clinical diagnoses of subtypes were made by specified criteria. RESULTS: The incidence of @entity195 of mild and greater severity was 2.7/1000 @entity1 -years at risk (1.6-4.4); in @entity1 1.5 (0.8-2.7) and in @entity1 3.3 (1.8-5.9). The incidence of @entity1294 was 1.2/100 @entity1 -years at risk (0.7-1.9); in @entity1 1.1 (0.4-2.8) and in @entity1 1.2 (0.7-2.0). @entity195 , but not @entity1294 , showed a marked increase with age, particularly in @entity1 . Rates for minimal @entity303 of different subtypes showed similar age and sex effects, but were much higher for @entity195 than @entity1294 . CONCLUSIONS: The striking rise in incidence rates of @entity303 in the very old appear to be due to @entity195 , while rates for @entity1294 remain relatively constant. These trends are particularly marked for minimal @entity303 , but emphasise the importance of @entity195 in the community as a cause of @entity73 of all degrees.
