Two cases of concurrent development of XXXX with @entity1072 , one related to clonal B-cell @entity6113 , tested by array comparative genomic hybridization.

@entity6113 @entity1 @entity1148 @entity706 @entity5 @entity1373 @entity1072 @entity4016 @entity4017 @entity74 @entity1893 @entity4407 @entity5315
We present two cases of concurrent development of @entity4407 ( @entity4407 ) with @entity1072 ( @entity1072 ) and one related to clonal B-cell @entity6113 ( @entity5315 ). Both @entity1 were referred for @entity6113 and @entity1148 . A bone marrow biopsy revealed infiltration of small, mature lymphocytes and @entity1373 . Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both @entity1 were positive for the @entity4016 @entity4017 mutation in whole bone marrow aspirate. The @entity4016 @entity4017 mutation was present in isolated B lymphocytes of @entity1 1, but not @entity1 2. Cytogenetics were normal in both @entity1 . An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in @entity1893 , in @entity1 1, and deletion 22q11.22, which is associated with @entity1072 , and a gain of Xp22.31 in @entity1 2. In both @entity1 , B cells showed no @entity5 ( @entity5 )-specific @entity74 . These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of @entity4407 and @entity1072 (or @entity5315 ). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of @entity706 and @entity5 .
