Bronchoalveolar lavage surfactant protein a, B, and d concentrations in preterm XXXX ventilated for @entity649 receiving natural and synthetic surfactants.

@entity1 @entity3231 @entity649 @entity26 @entity9914 @entity25097
Surfactant proteins (SPs) play an important role in surfactant metabolism and function. Understanding their relative contribution to clinical outcome remains incomplete. Exogenous surfactants differ in their SP content and physiologic effects. The aims of this study were to measure bronchoalveolar lavage (BAL) SP concentrations from preterm @entity1 ventilated for @entity649 and to assess their association with clinical outcome. Fifty preterm @entity1 randomized to receive a natural or synthetic surfactant were lavaged each day for the first week and twice weekly thereafter using a standardized nonbronchoscopic technique. BAL @entity3231 , @entity25097 , and @entity9914 concentrations were measured using ELISA. Median BAL @entity3231 , @entity25097 , and @entity9914 concentrations for the whole cohort rose significantly during the first postnatal week (p < 0.05). @entity3231 concentration did not differ between outcome groups. BAL @entity25097 concentration rose significantly in lungs that were not supplemented with @entity25097 . @entity1 dying had significantly lower BAL @entity25097 concentrations on d 2 and 6 compared with survivors. BAL @entity9914 concentrations were significantly lower on d 2 and 3 among @entity1 in supplemental @entity26 on d 28 compared with those in air. BAL @entity3231 and @entity9914 concentrations did not differ significantly between @entity1 randomized to receive a natural or synthetic surfactant. Lower BAL @entity25097 and @entity9914 but not @entity3231 concentrations were associated with worse clinical prognosis.
