Inhibition of @entity4833 modulates the autoregulation of cerebral blood flow and @entity63 brain metabolism in @entity101 XXXX .

@entity101 @entity2806 @entity63 @entity855 @entity4833 @entity880 @entity11544 @entity35 @entity551 @entity2388 @entity934
We designed the present study to examine whether or not the inhibition of @entity4833 modulates cerebral microcirculation in @entity551 and improves brain metabolism in @entity63 induced by bilateral carotid artery occlusion in @entity101 @entity35 . Blood flow to the parietal cortex was determined by the H2 clearance method. @entity880 , @entity2388 , and @entity855 were estimated by enzymatic methods. @entity4833 inhibitor (AChEI, @entity11544 ), at 0.05, 0.1, or 0.5 mg/kg, was intravenously injected 10 min before either hemorrhagic @entity551 or @entity2806 . The levels of @entity934 in the control were 29.3 +/- 8.1 (mean +/- SD) and 39.5 +/- 8.1 pmol/mg in the cortex and hippocampus, respectively, and they were significantly decreased by 15-19% after 60 min of @entity63 in the vehicle-treated @entity35 . AChEI preserved the levels to 93-98% of the control (p < 0.05 versus vehicle). The lower limit of autoregulation was 74 +/- 9% of the resting values. The administration of AChEI helped preserve blood flow and lowered the limit to 64 +/- 6% (p < 0.05 versus control). After 60 min of @entity63 , @entity880 increased 6.5-fold and @entity855 decreased to 64% of the control value. The administration of AChEI dose-dependently reduced the @entity880 level 1.9- to 3.9-fold and well preserved the @entity855 level to 94-97% of the control. The inhibition of @entity4833 activity may preserve cerebral autoregulation during @entity551 and protect cerebral metabolism against ischemic insult.
