The sonographical and functional sequelae of de Quervain's XXXX : long-term follow-up.

@entity1 @entity1375 @entity1218 @entity4941
Fifty-three @entity1 with @entity4941 ( @entity4941 ) were seen during the acute stage of the disease. HLA-Bw 35 was positive in 33 out of 39 tested @entity1 . At first presentation, all examined @entity1 (N = 23) had ultrasound abnormalities (generalized hypodensity, single or multiple hypodense areas). Serum T4 and/or T3 were increased in 24/52, free T4 in 11/23, and the TSH response to @entity1218 was flat in 8/11 @entity1 . Six of 12 in whom volumetry was performed had goitres. Thirty-seven @entity1 were re-examined after a mean follow-up interval of 46.5 months. At this follow-up, serum T4, free T4 and T3 levels as well as the sonographically determined thyroid volume had decreased, but there was still abnormalities by ultrasound detected in 14/36 @entity1 ; 19.4% had focal sonolucent lesions, whereas the prevalence of such lesions was only 3.1% in asymptomatic controls. Three @entity1 were @entity1375 at the follow-up, whereas all others were euthyroid. @entity1 with abnormal ultrasound findings were of the same age and had a similar thyroid size, but a slightly higher TSH and a significantly (P less than 0.02) lower free T4 than those with normal ultrasound findings. They also had a higher prevalence of thyroid autoantibodies in low titres. Serum thyroglobulin was elevated in more than half of the @entity1 during the acute phase, but only in 1 out of 11 @entity1 during follow-up. Thyroglobulin at the follow-up was not related to TSH, but there was a correlation with thyroid volume (r = 0.57).(ABSTRACT TRUNCATED AT 250 WORDS)
