EQOFIX: a combined economic and quality-of-life study of XXXX treatments in France.

@entity4682 @entity1 @entity548 @entity4777
BACKGROUND: EQOFIX is a medicoeconomic study that analyzed the health-related quality of life (HRQoL) and costs of care of the moderate and severe forms of @entity4777 , treated on demand or by prophylaxis with either plasma-derived Factor IX (pdFIX) or recombinant @entity4682 (rFIX). STUDY DESIGN AND METHODS: The primary objectives were evaluations of the impact of @entity4777 on HRQoL and of the costs associated with its management. The secondary objectives were evaluations of the clinical efficacy and costs of care of pdFIX and rFIX. In this observational study we included and followed for 1 year severe and moderate @entity4777 @entity1 without inhibitor. HRQoL was evaluated through generic and disease-specific questionnaires. Information on the health resources consumed was collected every 3 months. RESULTS: The EQOFIX cohort was composed of 155 @entity1 , including 51 @entity1 and 104 adults, with 114 having severe disease and 41 having moderate disease. The regimens were prophylactic for 61 and on demand for 94. Altogether, 78 were treated with rFIX and 77 with pdFIX. There was no difference in the QoL between the pdFIX and rFIX treatments. The extra cost of prophylaxis was    22,605 per @entity548 event prevented. The consumption of @entity4682 was 1.4-fold higher for the @entity1 treated with rFIX than for the @entity1 treated with pdFIX. CONCLUSION: Our findings in a cohort composed of 25% of the French population of moderate and severe @entity4777 @entity1 show, with similar clinical and HRQoL results, that treatment with rFIX is more expensive than treatment with pdFIX.
