Mean platelet component as an indicator of platelet activation in foals and adult XXXX .

@entity1 @entity1641 @entity882 @entity63 @entity344 @entity5642 @entity1681
BACKGROUND: Mean platelet component (MPC) is a new platelet variable, measured by modern commercial complete blood count analyzers, that is reduced during platelet activation in @entity1 and small animals. HYPOTHESIS: MPC decreases in @entity1641 with clinical conditions that cause platelet activation and @entity5642 ( @entity5642 ). ANIMALS: We obtained 418 CBCs from 100 sick and 20 healthy neonates and 178 sick and 45 sound adult @entity1641 . Sick neonates were classified into septic and nonseptic, and @entity5642 and non- @entity5642 groups. Adults were grouped by diagnoses (systemic inflammatory disorders, @entity344 , and @entity882 ). METHODS: MPC together with platelet count, mean platelet volume, platelet distribution width, and platelet component distribution width were measured with a commercial analyzer and compared between the different disease and control groups in neonates and in adults. RESULTS: MPC values were significantly lower in the septic and nonseptic neonates (24.0 +/- 3.5 g/dL and 26.6 +/- 2.6 g/dL, respectively) than in the control group (28.1 +/- 1.7 g/dL). Neonates with @entity5642 had the lowest MPC values (23.8 +/- 6.3 g/dL). MPC values in adult @entity1641 were significantly lower in the inflammatory (23.5 +/- 4.7 g/dL), @entity344 (23.0 +/- 5.0 g/dL), @entity1681 (23.6 +/- 4.6 g/dL), @entity63 (23.9 +/- 5.1 g/dL), and @entity882 (20.2 +/- 5.7 g/dL) groups when compared with control @entity1641 (26.2 +/- 3.5 g/dL). Other platelet variables were not different between the control and the disease groups. CONCLUSION AND CLINICAL IMPORTANCE: MPC might be a useful variable for quickly and easily detecting platelet activation in sick neonates and adult @entity1641 .
