Predictive and prognostic molecular markers for XXXX in Han Chinese population.

@entity1 @entity32 @entity73334 @entity73335 @entity66 @entity470 @entity5 @entity73337 @entity189 @entity2963 @entity47325 @entity201 @entity1086 @entity73336
@entity201 ( @entity201 ) is the most common @entity189 with a high incidence in Asia. Most @entity1 would die within 1 year after diagnosis and the 5 year survival rate is less than 10-20% worldwide. Single nucleotide polymorphisms (SNPs) in genes regulate telomere maintenance, mitosis, and @entity32 , and may help predict individual susceptibility to certain drugs, environmental factor, and risks to @entity66 . The gene-gene interaction and the regulation of SNPs have not been assessed extensively in @entity201 . According to our previous study, the GRB2-associated-binding protein ( @entity47325 ) gene @entity73334 (X(2) =5.015, P=0.025, OR=0.531, 95% CI 0.304-0.928) and @entity470 ( @entity470 ) gene @entity73335 (X(2) =7.934, P=0.005, OR=2.148, 95% CI 1.255-3.675) presented significant difference between @entity201 @entity1 and controls. This study conducted a population-based analysis using 225 @entity201 cases (153 biliary tract @entity5 @entity1 and 72 @entity1086 @entity1 ) to assess the association between SNPs and progression of @entity201 @entity1 , including the overall survival and the prognosis analysis. Results showed that an increased susceptibility of BTC was significantly associated with SNP loci distribution frequency in @entity470 @entity73336 (X(2) =7.934, P=0.005, OR=2.148, 95% CI 1.255-3.675). Furthermore, multivariate factor regression analysis represented @entity2963 medical history of BTC @entity1 can be an effective evaluation criteria of BTC susceptibility in early stage. This study also assessed the relationship between these genotypic polymorphisms and clinicopathologic data, including @entity5 differentiation stage and overall survival. This is the first study identifying that @entity470 polymorphisms are associated with BTC and @entity470 @entity73337 polymorphisms may be an important survival predictor in BTC @entity1 .
