Interaction between XXXX and ovarian hormones on the systemic @entity2135 axis.

@entity35 @entity54850 @entity2135 @entity67712 @entity3147 @entity230 @entity9929
OBJECTIVE: In @entity3147 both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex @entity230 are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS: Peripubertal (30 days of age) female @entity35 were either sham operated or ovariectomized. Five days later half of each group was submitted to a protein-caloric restriction diet. All @entity35 were killed at 60 days of age. RESULTS: Growth was decreased in all @entity35 submitted to calorie restriction and this was consistent with a decrease in circulating @entity2135 concentrations and liver @entity2135 mRNA expression. While in normally fed @entity35 ovariectomy had no significant effect on serum @entity2135 concentrations, ovariectomized and underfed @entity35 had significantly higher levels than intact underfed @entity35 . In undernourished rats, serum @entity67712 concentrations were significantly reduced and this was not modified by ovariectomy. In contrast, liver mRNA concentrations of @entity54850 were increased and @entity9929 unchanged in intact undernourished animals, suggesting that undernutrition could be affecting the proteolysis of these binding proteins, and this response was significantly modulated by ovariectomy. CONCLUSION: These results indicate that the presence of circulating ovarian hormones significantly affects the response of the IGF system to undernutrition.
