Portacaval shunt as treatment for hypercholesterolemia. Metabolic and morphological effects in a XXXX model.

@entity1707 @entity753 @entity165 @entity731
Since 1973 the portacaval shunt has been used as a treatment for homozygous @entity753 . Favorable results have been reported, but the mechanism or reduction of @entity165 is not clear. The objective of this research was to evaluate mechanisms of lipid alterations after portacaval shunting in Yucatan miniature @entity1707 . The animals were fed a high-fat diet, similar in composition to the average American diet, with or without added @entity165 . Controls were fed the atherogenic diet (+ @entity165 ) for 8 months. @entity1707 were fed atherogenic or American diets for 8 months, then surgery (shunt or sham) was performed. They were continued on the diets for another 8 months. The vascular system was examined for the distribution and severity of @entity731 . Blood lipids and numerous biochemical indices were measured. Progression of @entity731 was slowed by portacaval shunting. Low density lipoprotein (LDL) concentrations were positively and high density lipoprotein (HDL) concentrations were negatively correlated with severity of @entity731 . Serum insulin concentrations were positively correlated with @entity731 . @entity165 synthesis was increased by the shunting and decreased by @entity165 feeding. The @entity165 -fed @entity1707 is not an adequate model for @entity753 , but the results are consistent with inhibition of the @entity731 process and the involvement of lipoproteins and insulin in the mechanisms.
