Effect of XXXX Down-Regulation on Growth and Invasion of @entity189 and Related Immune Function.

@entity26607 @entity5 @entity189 @entity98 @entity1820 @entity379 @entity3 @entity1199 @entity3646 @entity688
UNASSIGNED: BACKGROUND MicroRNA (miR) has been proved to be an important biomarker for @entity5 because it can regulate occurrence, progression, invasion, and @entity3 of @entity5 . A previous study has shown the involvement of @entity26607 in multiple @entity1820 . Its detailed role and immune regulatory function in @entity189 , however, remains unknown. This study thus investigated the effect of @entity26607 in regulating growth, proliferation, and invasion of @entity5 and its influence on cytokine secretion. MATERIAL AND METHODS @entity189 cell line EC9706 and normal esophageal epithelial cell line HEEC were transfected with @entity26607 inhibitor. @entity98 assay was used to quantify the cell proliferation, and a Transwell chamber was used to evaluate cell invasion. Release of cytokines, including @entity1199 ( @entity1199 ), @entity3646 , @entity688 , and @entity379 ( @entity379 ), was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS @entity26607 expression was significantly elevated in @entity189 cells (p<0.05). The specific inhibition of @entity26607 expression remarkably suppressed proliferation and invasion of @entity5 cells. It can also down-regulated @entity1199 and @entity379 expression and facilitate secretion of @entity3646 and @entity688 when compared to the control group (p<0.05 in all ceases). CONCLUSIONS The inhibition of @entity26607 can effectively inhibit @entity5 progression and improve immune function, suggesting its potency as a novel drug target for @entity5 treatment.
