[ XXXX and @entity73 ].

@entity1 @entity2003 @entity12911 @entity304 @entity303 @entity73 @entity71 @entity935 @entity3072 @entity26630 @entity191 @entity9576 @entity1832 @entity400 @entity195 @entity10334 @entity4943 @entity7463 @entity528 @entity14827
The cognitive (executive) ability of @entity1 with @entity191 ( @entity191 ) deteriorates gradually during the progression of the disease. Fluency of speech, word finding, working memory, ability to plan the future and flexibility decline. @entity73 was found to be proportional with the speech, posture, gait and balance problems and can not be influenced by L-dopa substitution. Apart the dorsal and ventral mesolimbic dopaminergic systems the coerulo-cortical noradrenergic, serotoninergic and cholinergic systems are also impaired in @entity191 . Subcortical @entity303 in @entity191 can also be explained by the functional disability of dorsolateral and anterior cingular circuits. @entity71 can be explained by the @entity935 depletion of cingular cortex. Cortical Lewy bodies, @entity3072 , neurit plaques and additional vascular pathology should also play a role in @entity73 of @entity191 . In several @entity14827 associating with @entity191 ( @entity191 ) i.e. @entity7463 ( @entity7463 ), @entity528 ( @entity528 ), @entity9576 ( @entity9576 ) @entity303 can be detected with various severity, therefore the question arises concerning the correlation between @entity73 and @entity191 . @entity304 can also develop in @entity4943 ( @entity4943 ), @entity195 and @entity1832 ( @entity1832 ) but no correlation exists between motor disability and severity of @entity303 . In @entity1832 can be the initial symptom in 18% of cases but @entity191 can also preceeds the @entity303 . In @entity7463 profound depletion of other monoaminergic neurotransmitter system was also reported. In @entity26630 associated with @entity191 @entity528 , locus coeruleus and basal nucleus of Meynert has been reported with increased number of @entity3072 . In @entity1 with vascular @entity191 (VP) there is generally no @entity400 and @entity2003 , @entity12911 , @entity303 , gate disturbance, incontinency appears; L-dopa treatment is generally ineffective. In VP no cellular loss can be found within the substantia nigra, but @entity10334 , lacunae in the white matter and basal ganglia are commonly demonstrated.
