@entity20319 and XXXX variants modify malignant mesothelioma risk: a case-control study.

@entity1 @entity11833 @entity5 @entity20322 @entity20319 @entity20315 @entity3620 @entity1355
@entity3620 ( @entity3620 ) is a rare aggressive @entity5 associated with @entity1355 exposure. The possible role of genetic factors has also been suggested and @entity3620 has been associated with single nucleotide polymorphisms (SNPs) of xenobiotic and oxidative metabolism enzymes. We have identified an association of the DNA repair gene @entity20319 with @entity3620 in the population of Casale Monferrato, a town exposed to high @entity1355 pollution. To extend this observation we examined 35 SNPs in 15 genes that could be involved in @entity3620 carcinogenicity in 220 @entity3620 @entity1 and 296 controls from two case-control studies conducted in Casale (151 @entity1 , 252 controls) and Turin (69 @entity1 , 44 controls), respectively. Unconditional multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Two DNA repair genes were associated with @entity3620 , i.e. @entity20319 and @entity11833 . Considering @entity1355 -exposed only, the risk increased with the increasing number of @entity20319 -399Q alleles (Casale: OR=1.44, 95%CI 1.02-2.03; Casale+Turin: OR=1.34, 95%CI 0.98-1.84) or @entity20319 -77T alleles (Casale+Turin: OR=1.33, 95%CI 0.97-1.81). The @entity20319 -TGGGGGAACAGA haplotype was significantly associated with @entity3620 (Casale: OR=1.76, 95%CI 1.04-2.96). @entity1 heterozygotes for @entity11833 @entity20315 showed an increased OR in all subjects (OR=1.66, 95%CI 1.06-2.60) and in @entity1355 -exposed only (OR=1.59, 95%CI 1.01-2.50). When the dominant model was considered (i.e. @entity11833 heterozygotes CT plus homozygotes CC versus homozygotes TT) the risk was statistically significant both in all subjects (OR=1.61, 95%CI 1.06-2.47) and in @entity1355 -exposed only (OR=1.56, 95%CI 1.02-2.40). The combination of @entity11833 @entity20315 and @entity20319 @entity20322 was statistically significant (Casale: OR=2.02, 95%CI 1.01-4.05; Casale+Turin: OR=2.39, 95%CI 1.29-4.43). The association of @entity3620 with DNA repair genes support the hypothesis that an increased susceptibility to DNA damage may favour @entity1355 .
