Use of XXXX studies in predicting @entity439 of acute type B  aortic dissections.

@entity1 @entity449 @entity384 @entity5173 @entity439
OBJECTIVE: Whereas uncomplicated acute type B aortic dissections are often medically managed with good outcomes, a subset develop subacute or chronic @entity384 . We hypothesized that @entity5173 ( @entity5173 ) simulations may be useful in identifying @entity1 at risk for this complication. METHODS: @entity1 with acute type B dissection complicated by rapidly expanding @entity449 (N  = 7) were compared with @entity1 with stable aortic diameters (N  = 7). Three-dimensional @entity1 -specific dissection geometries were generated from computed tomography angiography and used in @entity5173 simulations of pulsatile blood flow. Hemodynamic parameters including false lumen flow and wall shear stress were compared. RESULTS: @entity1 with rapid @entity439 had a growth rate of 5.3     2.7  mm/mo compared with those with stable aortic diameters, who had rates of 0.2     0.02  mm/mo. Groups did not differ in initial aortic diameter (36.1     2.9 vs 34.4     3.6  mm; P  = .122) or false lumen size (22.6     2.9 vs 20.2     4.5  mm; P  = .224). In @entity1 with rapidly expanding @entity439 , a greater percentage of total flow passed through the false lumen (78.3%     9.3% vs 56.3%     11.8%; P  = .016). The time-averaged wall shear stress on the aortic wall was also significantly higher (12.6     3.7 vs 7.4     2.8  Pa; P  = .028). CONCLUSIONS: Hemodynamic parameters derived from @entity5173 simulations of acute type B aortic dissections were significantly different in dissections complicated by @entity439 formation. Thus, @entity5173 may assist in predicting which @entity1 may benefit from early stent grafting.
