Extract of Artemisia lavandulaefolia Inhibits In Vitro Angiogenesis in XXXX Umbilical Vein Endothelial Cells.

@entity5 @entity1 @entity3
Angiogenesis is important processes for @entity5 growth and @entity3 . Anti-angiogenesis target therapy has recently been known to be new anti- @entity5 therapeutic strategies. Natural products such as traditional medicine comprise a major source of angiogenesis inhibitors. Artemisia lavandulaefolia has been known to use in the traditional medical practices. However, its molecular mechanism on the @entity5 protection and therapy was not clearly elucidated. In this study, we investigated the possibility that extract of A. lavandulaefolia inhibits in vitro angiogenesis. Therefore, we examined the effect of extract of A. lavandulaefolia on the vascular network formation of @entity1 umbilical vein endothelial cells (HUVECs). We found that the treatment of A. lavandulaefolia extract suppressed the tube formation of HUVECs without any influence on the viability of HUVECs. In addition, extract of A. lavandulaefolia inhibited the migration and invasion of HUVECs. These results suggest that extract of A. lavandulaefolia could be act for an angiogenic inhibitor.
