The long-term outcome in XXXX .

@entity1 @entity30
The long-term outcome of @entity30 was reviewed in 139 @entity1 who were treated at the Cleveland Clinic for a minimum of 15 years. At the time of diagnosis, 38 (27 percent), 39 (28 percent) and 62 (43 percent) @entity1 had small-bowel, large-bowel, and ileocolic patterns of disease, respectively. The disease progressed with time and, eventually, 104 (75 percent) @entity1 had @entity30 . One hundred twenty-two @entity1 (88 percent) underwent at least one definitive operation for the disease. Forty-four (32 percent) @entity1 had proctocolectomies and 65 (47 percent) have ileostomies. Associated manifestations of @entity30 occurred in a high proportion of @entity1 ; perianal disease in 78 (56 percent), intestinal fistulas in 45 (32 percent), extraintestinal disease in 49 (35 percent). Six @entity1 died of causes directly related to the disease. Specific complications tend to occur at definite times in the course of the disease. @entity30 is not a benign condition. There is a relentless progression of the disease and a high incidence of complications when @entity1 are followed over a long period.
