Plasmapheresis therapy in @entity7271 and XXXX .

@entity1 @entity7271 @entity1713 @entity4530 @entity229 @entity7248
Blistering dermatitises are characterized by the presence of blisters that begin owing to acantholysis ( @entity4530 ) such as @entity7271 ( @entity7271 ) or owing to @entity1713 ( @entity4530 ) such as @entity7248 ( @entity7248 ). Both diseases are autoimmune pathologies characterized by the presence of autoantibodies against specific adhesion molecules of the skin and mucous membranes. @entity7271 , in which oral lesions are always present, has a progressive course that, if the disease is not treated, nearly always brings to death from sepsis within a few years. In @entity7248 , oral lesions are rare and the disease, that is most frequent in older individuals, has a chronic course with spontaneous remissions. Systemic corticosteroids and immunosuppressants are the mainstay of treatment of these two diseases. Although this therapy had reduced the mortality of the two pathologies it is associated with serious side effects. To reduce the corticosteroids dose and to improve the symptomatology in resistant therapy cases, we treated five @entity1 with several procedures of plasma exchange. Four @entity1 were affected by @entity7248 and one by @entity7271 . Their disease severity at onset of plasmapheresis ranged from mild to severe. One of 5 @entity1 suffered a plasmapheresis side effect. All @entity1 responded with complete remission of symptomatology and had a @entity229 dosage reduction until 70%. Plasmapheresis is an effective treatment for @entity7271 and @entity7248 @entity1 who have been unresponsive to conventional therapy, for those for whom conventional drugs are contraindicated, for those who show severe clinical manifestations and for those who need high doses of corticosteroids and immunosuppressants to keep the disease under control.
