Comparison of percutaneous absorption of fragrances by XXXX and monkeys.

@entity1 @entity137 @entity61887 @entity167 @entity72318 @entity2608 @entity27469
The percutaneous absorption of two cosmetic fragrance materials, @entity61887 and @entity72318 , as well as of cinnamic @entity167 and @entity27469 , has been measured at occluded and non-occluded application sites. Absorption values were determined in the @entity2608 in vivo. Absorption through @entity1 skin was measured by using excised skin in diffusion cells. Because of the insolubility in water of @entity61887 and @entity72318 , a nonionic surfactant solution (6% oleth 20) was used in the receptor chamber of the diffusion cell in order to facilitate the partitioning of the compounds from the skin into the receptor fluid. The relative volatility of the compounds was determined in order to aid in the interpretation of the absorption results. The greatest difference between in vivo and in vitro absorption values occurred with @entity61887 , which was the least well absorbed and the most volatile compound. @entity27469 absorption through non-occluded @entity1 skin (17.8 +/- 4.9%, mean +/- SEM) was significantly lower than through monkey skin (38.6 +/- 8.3%). The values for absorption through @entity1 and monkey skin did not differ significantly for @entity72318 (24.0 +/- 5.1% v. 26.1 +/- 2.3%) or cinnamic @entity167 (33.9 +/- 7.3% v. 25.4 +/- 4.4%). Occlusion of the skin resulted in greater permeation of all of the compounds; a significant difference in permeability between the two types of skin occurred only with @entity61887 . The fragrances were absorbed well, but their volatility must be considered in a @entity137 evaluation. There was reasonable agreement between the values obtained from the studies of the @entity1 skin in vitro and the monkey skin in vivo.
