The Effects of @entity12118 on Pain Control During the XXXX Injection; a Controlled, Double-Blinded, Randomized Clinical Trial.

@entity1 @entity12118 @entity1875 @entity158
BACKGROUND: The use of @entity1875 often results in @entity158 upon injection, which is sometimes very distressing for @entity1 . Many @entity1 report some degree of @entity158 or discomfort on injection with @entity1875 . Injection-induced @entity158 during induction of anesthesia can result in @entity1 's discomfort. OBJECTIVES: This study was performed to evaluate the effects of @entity12118 on @entity158 severity in @entity1 undergoing @entity1875 injection. @entity1 AND METHODS: In this double-blind randomized clinical trial, 100 @entity1 with ASA class I and II undergoing anesthesia with @entity1875 injection were selected for the study from 2012 to 2013 in Imam Reza training hospital. @entity1 were randomly assigned to case and control groups and received either 20  g of @entity12118 or normal saline as placebo. The severity of injection @entity158 was assessed using a four-point scale. An anesthesiologist observed hemodynamic and local adverse effects. RESULTS: The @entity158 severity in @entity12118 group was significantly lower compared with the placebo group (P < 0.0001). Moreover, the local adverse reactions were observed only in three @entity1 in the placebo group while no @entity1 in the drug group experienced adverse effects (P = 0.242). The systolic blood pressure showed no significant difference between two groups before and after the induction of anesthesia but the diastolic blood pressure and the heart rate was significantly different between study groups. CONCLUSIONS: @entity12118 may be a safe and effective adjuvant therapeutic for @entity158 reduction in @entity1 under @entity1875 injection. Hence, its use for reduction of @entity1875 injection-induced @entity158 is recommended.
