Prenatal acetaminophen induces @entity99 in dams, reduces fetal liver stem cells, and XXXX in adult offspring.

@entity1 @entity32 @entity39 @entity19 @entity565 @entity409 @entity56 @entity158 @entity99 @entity221
BACKGROUND _ AIMS: During pregnancy, acetaminophen is one of the very few medications recommended by physicians to treat @entity221 or @entity158 . Recent insights from epidemiological studies suggest an association between prenatal acetaminophen medication and an increased risk for development of @entity565 in @entity1 later in life. The underlying pathogenesis of such association is still unknown. METHODS: We aimed to develop a @entity19 model to provide insights into the effect of prenatal acetaminophen on maternal, fetal and adult offspring's health. The toxic effect of acetaminophen was studied in @entity19 on 1) maternal liver; mirrored by biomarkers of @entity99 , centrilobular @entity39 , and infiltration of granulocytes; 2) fetal liver; reflected by the frequency of hematopoietic stem cells, and 3) postnatal health; evaluated by the severity of @entity56 airway @entity32 among offspring. RESULTS: We observed an increased susceptibility towards acetaminophen-induced @entity409 in pregnant @entity19 compared to virgins. Moreover, hematopoietic stem cell frequency in fetal liver declined in response to acetaminophen. Furthermore, a greater severity of airway @entity32 was observed in offspring of dams upon prenatal acetaminophen treatment, identified lung infiltration by leukocytes and eosinophil infiltration into the airways. CONCLUSION: Our newly developed @entity19 model on prenatal use of acetaminophen reflects findings from epidemiological studies in @entity1 . The availability of this model will allow improvement in our understanding of how acetaminophen-related hepatotoxicity is operational in pregnant individuals and how an increased risk for @entity56 in response to prenatal acetaminophen is mediated. Such insights, once available, may change the recommendations for prenatal acetaminophen use.
