Intracellular XXXX in relation to glycaemic control in the myocardium: A pilot study in @entity1 .

@entity1 @entity296 @entity11395 @entity6 @entity13088 @entity13286
AIM: Intramyocellular @entity13286 have been implicated in the development of insulin resistance in skeletal muscle. In the myocardium, excess lipid storage may also contribute to the appearance of @entity13088 , while @entity13286 may have certain cardio-protective functions. However, little is known on intracellular @entity11395 accumulation in the @entity1 heart. We aimed to determine @entity11395 accumulation in the @entity1 myocardium in relation to @entity6 status. METHODS: Six @entity6 and six non- @entity6 aged @entity1 subjects undergoing by-pass surgery participated in the study. Subjects were matched for age and body mass index. Intracellular @entity11395 levels were measured in heart biopsy samples. Additional samples were taken from pectoralis major muscle that served as control. Whole body glycaemic control was assessed as the percent glycated haemoglobin. RESULTS: Intracellular @entity13286 were significantly higher in the myocardium compared to pectoralis major (P<0.05). Although not statistically significant, @entity6 subjects tended to accumulate smaller amounts of @entity13286 compared to non- @entity6 subjects in the myocardium. A linear negative correlation was observed between myocardial @entity13286 and glycaemic control (r=0.632, P<0.05). CONCLUSIONS: Our data suggest that poor glycaemic control and @entity6 may be associated with a defective accumulation of myocardial @entity13286 , possibly blunting intracellular processes and contributing to the development of @entity296 .
