The microtubule-associated molecular pathways may be genetically disrupted in XXXX with @entity162 . Insights from the molecular cascades.

@entity1 @entity24109 @entity162 @entity308 @entity5 @entity1091 @entity2403
UNASSIGNED: @entity162 is a severe disease characterized by pathological mood swings from major @entity308 episodes to @entity162 . The biological underpinnings of @entity162 have yet to be defined. As a consequence, pharmacological treatments are suboptimal. In the present paper we test the hypothesis that the molecular pathways involved with the direct targets of @entity1091 , hold significantly more genetic variations associated with @entity2403 . A molecular pathway approach finds its rationale in the polygenic nature of the disease. The pathways were tested in a sample of    7000 @entity1 and controls. Data are available from the public NIMH database. The definition of the pathways was conducted according to the National @entity5 Institute (http://pid.nci.nih.gov/). As a result, 3 out of the 18 tested pathways related to @entity1091 action resisted the permutation analysis and were found to be associated with @entity2403 . These pathways were related to @entity24109 , Integrins and Aurora. A pool of genes selected from the ones linked with the above pathways was further investigated in order to identify the fine molecular mechanics shared by our significant pathways and also their link with @entity1091 mechanism of action. The data obtained point out to a possible involvement of microtubule-related mechanics.
