Improvement in glomerular filtration rate may decrease mortality among type-2 diabetics with chronic kidney disease lacking XXXX : A retrospective study.

@entity1 @entity644 @entity8 @entity6 @entity740 @entity633 @entity177
UNASSIGNED: Twenty percent of @entity1 with @entity6 without @entity633 progress to @entity740 ( @entity740 ). The various factors related to development of @entity740 , the natural course of @entity8 as well as mortality in this sub-group of diabetics has not been studied in detail. The medical records of 121 @entity1 (all males) above the age of 40 years with @entity6 and @entity740 , and without @entity644 , were reviewed in this retrospective study. The outcomes measured included: (a) all-cause mortality, (b) need for hemodialysis (HD), (c) appearance of @entity644 and (d) trend in kidney function. The all-cause mortality was 33%, with mean age at death being 75.9 years. Sixty-three percent of the @entity1 had improvement in estimated glomerular filtration rate (eGFR) at the end of the follow-up period. The mortality was higher in @entity1 with worsening eGFR compared with those with improvement in eGFR (61% vs 39%, P = 0.040). 5.8% of the @entity1 ended up on HD and 16.51% developed @entity644 at the end of the follow-up period. @entity1 who developed @entity644 showed a higher tendency for progression of @entity177 . Multivariate logistic regression for trend toward improving versus worsening of the eGFR revealed no statistically significant predictors. This observational study suggests that in type-2 @entity6 @entity1 with @entity740 , a substantial number of @entity1 will have improvement in eGFR over time. Careful search for potential reversible causes of @entity8 could help in reducing mortality.
