[Fundamental and clinical studies of XXXX in obstetrics and gynecology].

@entity1 @entity281 @entity71726 @entity71727
The findings from recent fundamental and clinical studies of the efficacy of @entity71726 ( @entity71727 ) in obstetrics and gynecology are reported in this paper. The @entity71727 concentrations in genital tissues sampled 30 to 56 minutes (a mean of 41.4 minutes) after intravenous injection of 1 g of the drug were 14 to 76 micrograms/g (a mean of 32.4 micrograms/g). The mean transfer ratios of the drug into the genital tissues to the concentration in the uterine arterial blood were such that the transfer ratio into the portio vaginalis was the highest, followed by the uterine cervix and the myometrium, and that into the oviduct was the lowest with about 1/2 that into the portio vaginalis. The concentration in the antecubital venous blood and that in the uterine arterial blood remained similar for all @entity1 . The transfer of @entity71727 into the pelvic dead space exudate reached a peak (49.5 micrograms/ml) 1 hour, and also a peak (49.8 micrograms/ml) 2 hours after the intravenous injection. It then decreased gradually, but remained high, being higher than that in the antecubital venous blood about 50 minutes after the intravenous injection. Ten @entity1 with @entity281 in gynecology were treated with 1.0 to 4.0 g daily of @entity71727 , to a total dose of 6 to 52 g, over a period of 3 to 13 days. One of them showed excellent response, 8 showed moderate response, and another showed poor response to the treatment: in other words, a response rate of 90% was achieved. Bacteriologically, pathogens were eradicated from 3 and decreased in 3, and microbial substitution occurred in another @entity1 . No side effects of the drug were observed except for eruption in 1 @entity1 . None of the 10 @entity1 showed any abnormalities in laboratory findings. From the present fundamental and clinical studies of @entity71727 , we have drawn the conclusion that the drug is one of extremely useful antibiotics in the treatment of @entity281 in obstetrics and gynecology.
