Effects of @entity1388 on the XXXX sperm morphology test.

@entity3163 @entity19 @entity786 @entity911 @entity7034 @entity1388
There has been little information and much @entity911 regarding the genotoxic effects of @entity1388 . The purpose of this study was to examine the spermatogenic influence of @entity3163 ( @entity7034 ) on the germ cells by means of the @entity19 sperm morphology test. Male @entity19 of genotype B6C3F1 were obtained at about eight weeks of age and maintained on a low- @entity1388 diet (less than 0.2 ppm F) and distilled water ad libitum throughout the experiment. At approximately 13 weeks of age, the animals were randomly assigned to eight groups. Group I was intubated with the Maximum Tolerable Dosage (MTD) of @entity7034 (70 mg/kg). Groups II through VI received @entity7034 by stomach intubation at doses of 35, 20, 10, 1, and 0.1 mg/kg, respectively. Group VII served as a negative control and was intubated with distilled water. The positive control, Group VIII, was exposed to a known mutagen, @entity786 (20 mg/kg, i.p.). The animals were treated daily for five days, and killed by cervical dislocation 35 days after the first exposure to chemicals. Slides of sperm from the cauda epididymides were prepared and blindly scored for morphological abnormalities. Weight of the testes was recorded, and the femurs were saved for @entity1388 (F) analysis. Analysis of bone F demonstrated the effective absorption of @entity1388 following intubation. The counts of abnormal sperm and the weights of the testes for @entity19 exposed to @entity7034 doses up to the MTD were not significantly different from those of the negative control. The results of this study showed that @entity7034 did not have adverse effects on @entity19 sperm morphology.
