Cardiac effects of short course XXXX in preterm @entity1 .

@entity1 @entity1184 @entity619 @entity4346 @entity1030 @entity413
AIM: To examine the incidence and natural history of @entity4346 ( @entity4346 ) associated with the shorter 2-3 week course of @entity619 , now more usual, for @entity1030 . METHOD: Thirty one @entity1 , gestational age 23-34 (median 26) weeks, birthweight 500-2054 (median 815)g, received @entity619 , starting at 0.4-0.6 mg/kg/day, at a median of 11 days of age (range 2-34), weaning over a period of 2-3 weeks. Eighteen preterm neonates were studied as controls over a similar time period. Serial echocardiographic measurements of end diastolic interventricular septum (IVSd) and left ventricular posterior wall (LVPWd) thicknesses were taken before, and up to 48 days after, starting @entity619 . Maximum Doppler blood flow velocities from the left ventricular outflow tract (LVOT) were measured. RESULTS: @entity4346 ( @entity4346 ) occurred in 29 babies (94%). Median @entity1184 of the IVSd in those receiving @entity619 was 67% and LVPWd 56% of baseline measurements, significantly greater than control @entity1 (p < 0.001). @entity4346 appeared by a median of three days, peaking by a median of 10 days. All resolved by a median of 27 days. LVOT obstruction was not seen. There was no significant correlation with birthweight, gestation, blood pressure, or @entity413 tolerance. CONCLUSIONS: @entity4346 developed in almost all preterm neonates receiving a 2-3 week course of @entity619 , but was of little clinical importance and always resolved. Echocardiography is probably not required routinely in @entity1 receiving such short course @entity619 for @entity1030 .
