Insertion/deletion polymorphism in intron 16 of XXXX gene in idiopathic recurrent @entity2208 : case-control study, systematic review and meta-analysis.

@entity1 @entity2208 @entity1289 @entity5852
UNASSIGNED: The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( @entity1289 ) has been extensively studied as a predisposing factor for idiopathic recurrent @entity2208 (IRSA). A case-control study including 149 @entity1 with >= 3 spontaneous @entity5852 and 149 controls was performed to test the association of @entity1289 I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as >= 2 and >= 3 spontaneous @entity5852 . Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian @entity1 . Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for @entity1 were identified. Meta-analysis was performed and included four studies defining IRSA as >= 2 spontaneous @entity5852 and the current study, which defined IRSA as >= 3 spontaneous @entity5852 . Based on random effects model, meta-analysis conducted on 1192 @entity1 and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of @entity1289 I/D polymorphism in IRSA defined as >= 3 spontaneous @entity5852 .
