Correlation between expression of cyclooxygenase-2 and angiogenesis in human XXXX .

@entity5 @entity1373 @entity2280 @entity2101 @entity3 @entity2247 @entity356
AIM: To evaluate the expression of cyclooxygenase ( @entity2247 ) and the relationship with @entity5 angiogenesis and advancement in @entity356 . METHODS: Immunohistochemical stain was used for detecting the expression of @entity2247 in 45 resected specimens of @entity356 ; the monoclonal antibody against @entity2280 was used for displaying vascular endothelial cells, and @entity2101 ( @entity2101 ) was detected by counting of @entity2280 -positive vascular endothelial cells. Paracancerous tissues were examined as control. RESULTS: Immunohistological staining with @entity2247 -specific polyclonal antibody showed cytoplasmic staining in the @entity5 cells, some @entity1373 and intestinal metaplasia,as well as angiogenic vasculature present within the @entity5 and prexisting vasculature adjacent to @entity5 . The rate of expression of @entity2247 and @entity2101 index in @entity356 were significantly increased, compared with those in the paracancerous tissues (77.78 vs 33.33 %, 58.13+/-19.99 vs 24.02+/-10.28, P<0.01, P<0.05, respectively). In 36 @entity356 specimens with lymph node @entity3 , the rate of @entity2247 expression and @entity2101 were higher than those in the specimens without metostasis (86.11 vs 44.44 %, 58.60+/-18.24 vs 43.54+/-15.05, P<0.05, P<0.05, respectively). The rate of @entity2247 expression and @entity2101 in the specimens with invasive serosa were significantly higher than those in the specimens without invasion to serosa (87.88 vs 50.0 %, 57.01+/-18.79 vs 42.35+/-14.65, P<0.05, P<0.05). Moreover, @entity2101 in @entity2247 -positive specimens was higher than that in @entity2247 -negative specimens (61.29+/-14.31 vs 45.38+/-12.42,P<0.05). @entity2247 expression was positively correlated with @entity2101 (r=0.63, P<0.05). CONCLUSION: @entity2247 expression might correlate with the occurance and advancement of @entity356 and is involved in @entity5 angiogenesis in @entity356 . It is likely that @entity2247 by inducing angiogenesis can be one of mechanisms which promotes invasion and @entity3 of @entity356 . It may become a new therapeutic target for anti-angiogenesis.
