Association between XXXX levels and @entity65 events in older adults: the Health, Aging and Body composition study.

@entity1 @entity32 @entity650 @entity64 @entity301 @entity5 @entity39 @entity13490 @entity2690 @entity413 @entity1254 @entity209 @entity583 @entity65 @entity1851
OBJECTIVE: Prospective data on the association between @entity13490 levels and @entity65 ( @entity65 ) events are sparse with conflicting results. METHODS: We studied 3044 aged 70-79 years from the Health, Aging, and Body Composition Study. @entity65 events were defined as @entity301 ( @entity301 ) or @entity64 events.   Hard      @entity301 events were defined as @entity301 death or @entity583 . We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum @entity13490 concentrations and adjusted for clinical variables, and then further adjusted for @entity209 (body mass index, fasting plasma @entity413 , abdominal visceral and subcutaneous adipose tissue, leptin, @entity1254 , @entity2690 ) and @entity32 ( @entity1851 , @entity650 , @entity5 @entity39 factors-a). RESULTS: During a median follow-up of 10.1 years, 559 @entity1 had      hard      @entity301 events, 884 @entity301 events and 1106 @entity65 Events. Unadjusted incidence rate for @entity65 events was 36.6 (95% CI 32.1-41.1) per 1000 @entity1 -year in the lowest quartile and 54.0 per 1000 @entity1 -year in the highest quartile (95% CI 48.2-59.8, P for trend  <  0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of @entity13490 was 1.52 (95% CI 1.20-1.93, P  <  0.001) for      Hard      @entity301 events, 1.41 (95% CI 1.16-1.70, P  =  0.001) for @entity301 events and 1.35 (95% CI 1.14-1.59, P  =  0.002) for @entity65 events. Further adjustment for @entity209 slightly reduced the associations while adjustment for @entity32 markedly reduced the associations. CONCLUSIONS: In older adults, higher @entity13490 levels are associated with @entity65 events independently of clinical risk factors and @entity209 markers, but markedly @entity32 .
