On the issue of early and aggressive treatment in grade 2 XXXX .

@entity1 @entity5 @entity11 @entity816 @entity3271
PURPOSE: To study the effects of surgery and timing of radiotherapy on @entity1 survival in grade 2 @entity11 . METHODS: One hundred and eighty-nine @entity1 with diffuse @entity816 , @entity816 , and @entity3271 , World Health Organization grade 2, treated between 1982 and 2000 were identified. The impact of treatment given and clinical parameters were studied in univariate- and multivariate survival analyses. RESULTS: Median survival for the whole @entity1 sample was 6.4 years and the 5-year survival rate was 60%. Macroscopic total resection was beneficial in the univariate analysis (P=0.03) but not when adjusting for confounders. Early subtotal resection did not prolong survival. Early radiotherapy was associated with a shorter survival time compared to delayed or no irradiation (P=0.004). However, this difference was mainly due to an unequal distribution of prognostic factors and was not significant in the multivariate analysis. The most important predictors for long survival time were young age ( P<0.001), @entity3271 histology ( P<0.001), and small @entity5 size ( P=0.02). CONCLUSIONS: Early conventional treatment with surgery and radiotherapy had no positive effect on @entity1 survival. This opens up the possibility of trying and evaluating other first-line treatment regimens in this disease.
