[A clinical analysis of 32 cases of XXXX ].

@entity1 @entity1375 @entity6 @entity12692 @entity305 @entity2744 @entity7555
OBJECTIVE: To compare the clinical features of @entity7555 ( @entity305 , @entity7555 , @entity2744 , M protein and skin changes) syndrome @entity1 from Peking Union Medical College Hospital (PUMCH) with those of @entity1 in previous reports. METHODS: Thirty-two @entity1 with @entity7555 were identified in PUMCH over the last two decades. The clinical features of these @entity1 were compared with those in other large series from Japan, China, and the United States. RESULTS: The average age at presentation was 45.8 years; 22 were @entity1 . All 32 @entity1 had @entity305 and decreased knee-jerk reflex. @entity7555 was present in 31 @entity1 . Nine @entity1 underwent lymph node biopsy and 5 of them were proven to have @entity12692 . Twenty-six @entity1 had at least one endocrine abnormality at time of presentation, not including more commonly prevalent @entity6 or @entity1375 . Seventy-two percent (18/25) of the @entity1 had a detectable monoclonal protein with serum immunofixation, but only 16.7% (4/24) had positive results with serum protein electrophoresis. Skin changes were documented in 30 @entity1 . In comparison with other series, we found a higher prevalence of @entity7555 and papilloedema. The rates of M protein level, however, were similar. CONCLUSIONS: Most features of our series are similar to those from previous foreign series. The prevalence of M protein in our study was similar to that in previous foreign series, but was not as low as reported in previous Chinese studies. Immunofixation and immunohistochemical staining of bone marrow biopsies are probably more sensitive in detecting M protein as compared with serum protein electrophoresis.
