Sleep-associated variations in plasma XXXX activity and blood pressure in the @entity35 .

@entity11755 @entity1 @entity35 @entity3449
Plasma @entity3449 activity (PRA) was determined in plasma samples obtained approximately at 6-min intervals during consecutive non- @entity11755 (NREMS) and @entity11755 ( @entity11755 ) periods in @entity35 chronically implanted with EEG electrodes, a brain thermistor, and an intracardiac catheter. PRA was low in @entity11755 and high in NREMS: this difference was statistically significant. The PRAs in wakefulness and NREMS were not different. Sleep-associated variations in systemic blood pressure (BP) were also recorded in a group of @entity35 implanted with a chronic aortic catheter. During @entity11755 , large oscillations superimposed on a tonic rise in BP were observed, and the end of @entity11755 was followed by an abrupt fall in BP. This is the first demonstration of sleep-associated variations in PRA in a species other than @entity1 . The changes in BP in the @entity35 during @entity11755 confirm previous reports and, unlike those in many other species, are similar to those previously described in @entity1 . The @entity35 therefore provides a model for study of the mechanisms of the sleep-related variations in PRA and BP. The changes in PRA may reflect a regulatory response to variations in BP or may result from central mechanisms, e.g. the sleep-associated changes in serotonergic activity.
