[Significance of XXXX in chronic respiratory tract diseases in childhood].

@entity1 @entity4443 @entity70865 @entity4352 @entity358 @entity2101 @entity223 @entity1030 @entity11130
The role of lipoxygenase products was studied in @entity1 suffering from @entity1030 . @entity4443 C4, D4, @entity70865 were measured by @entity2101 ( @entity2101 ) and a specific radioimmunoassay (RIA) for C4. Elevated levels (up to 40 ng/ml), especially for @entity4352 E4, were found in plasma of asthmatic and bronchitic @entity1 ( @entity4352 C4 concentrations varied between 0.05 and 40 ng/ml, mean 4.9 +/- 7.8 ng/ml). In healthy donors the concentrations were below the detection limits of @entity2101 , @entity4352 C4 ranging between 5 +/- 4 ng/ml (RIA data). The conversion of @entity4352 C4 to D4 and E4 was observed by incubating the samples with synthetic @entity4352 C4. The half-life of @entity223 in plasma varied greatly, ranging from less than 12 min to 72 min (mean 39 +/- 16 min). Bronchial lavages yielded @entity4352 C4 concentrations of 0.2 to 7 ng. @entity11130 was detected in 10 of 41 cases. Conversion of @entity4352 C4 did not occur in 50% of all cases, but was regularly observed in putrid lavages. These data suggest that @entity4443 play an important role in allergic and @entity358 .
