Relation of osteocalcin with XXXX resistance and histopathological changes of non alcoholic fatty liver disease.

@entity1 @entity82 @entity1674 @entity2690 @entity1561 @entity413 @entity165
BACKGROUND: Osteocalcin is a hormone with a complex cross-talk between adipose tissue and the skeleton. The aim of the present study was to explore the relation of osteocalcin with histopathological changes of NALFD @entity1 . SUBJECTS: A population of 69 @entity1561 @entity1 was analyzed. A liver biopsy was realized. Weight, fat mass, body mass index, basal @entity413 , @entity2690 , @entity2690 resistance (HOMA), total @entity165 , LDL @entity165 , HDL- @entity165 , @entity1674 and osteocalcin levels were measured. RESULTS: @entity1 were divided in two groups by median osteocalcin value (11.34 ng/mL), group I ( @entity1 with the low values) and group II ( @entity1 with the high values). Only liver @entity82 frequencies were different between groups (group I: 22.9% vs group II: 9.4%; p < 0.05). @entity1 in group I had higher levels of @entity413 (115.6    28.1 mg/dL vs. 103.7    24.3 mg/dL; p < 0.04), HOMA (4.6    3.1 units vs. 3.6    1.8 units; p < 0.04), weight (102.9    32.4 kg vs. 85.9    16.8 kg; p = 0.002) and body mass index (38.3    11.4 kg/m(2) vs. 30.1    5.7 kg/m(2); p = 0.001)) than @entity1 in group II. Osteocalcin was inverse correlated with @entity413 (r =-0.4; p = 0.002) and HOMA (r = -0.3:p = 0.01). CONCLUSION: Osteocalcin is associated with liver @entity82 . However, this association disappeared in a multivariate analysis, and HOMA remained as an independent factor.
