[Effects of low concentration carbon monoxide on the neurobehavior function in XXXX ].

@entity19 @entity137 @entity1054
OBJECTIVE: To study the effect of low concentration CO on neurobehaviour function and the maximal allowable concentration (MAC) in limited time. METHOD: 40 KM (kunming) male @entity19 were randomly divided into groups A, B, C and D. They were exposed to normal air, 30 mg/m3 CO, 300 mg/m3 CO and 600 mg/m3 CO respectively. The changes in neurobehaviour function of the @entity19 before, during and after 72 h exposure in 0.5 m3 static chambers were observed. Four indices were measured: @entity1054 ( @entity1054 ) and error rate (ER) in the water maze test, enter check frequency (ECF) and urine or excrement frequency (UEF) in open field test. RESULT: The set upright frequency in group D was smaller than those in groups A, B and C during exposure. @entity1054 and ER values went in a direction contrary to pre-exposure the four groups in the second 3 days (6 d) after or out of exposure, while ER values showed that group D > group C > group A > group B in the third 3 days (9 d). @entity1054 value was not different among the 4 groups, but its order of numerical value was similar to the ER order. The order of ECF values was that group C > group A and group D in 3 d after or out of exposure and not different among the 4 groups in 6 d and group D < group A and group B in 9 d. UEF values were not different among the 4 groups in 3 d and 9 d, but group D > group A and group B in 6 d after or out of exposure. Comparison with every group itself, showed statistically significance increase in ER values in 9 d out of exposure than before exposure in group D. ECF values showed the statistics significant increase in 9 d in group A and B. CONCLUSION: Low concentration CO may interfere with the learning and memory of @entity19 in the water maze and impede the development of the motor nervous function and disturb the steadiness of emotion of @entity19 in the open field. In addition, low concentration of CO may be of @entity137 .
