Carotid wall thickness and years since bilateral oophorectomy: the Los Angeles XXXX Study.

@entity1 @entity301 @entity7793 @entity731 @entity121 @entity65 @entity165
Evidence that @entity301 risk increases with surgical @entity7793 is consistent. However, findings concerning @entity731 and surgical @entity7793 are inconsistent. The Los Angeles @entity731 Study (1995-1996) assessed the cross-sectional relation at baseline between years since bilateral oophorectomy and common carotid artery @entity121 ( @entity121 ). @entity1 included 269 employed California @entity1 asymptomatic for @entity65 and aged 45-60 years. Ninety-seven @entity1 reported a hysterectomy: 42 without oophorectomy or a unilateral oophorectomy and 55 with a concurrent bilateral oophorectomy. @entity121 was measured bilaterally with B-mode ultrasound and was regressed on age, height, and years since hysterectomy in each group. Among @entity1 who had undergone bilateral oophorectomy, @entity121 was significantly related to years since hysterectomy (beta = 0.042 (standard error, 0.018) mm/10 years, p = 0.02). However, @entity121 was unrelated to years since hysterectomy in the no bilateral oophorectomy group (beta = 0.005 (standard error, 0.023) mm/10 years, p = 0.82). Adjustment for high density lipoprotein or low density lipoprotein @entity165 attenuated the association between @entity121 and years since hysterectomy by about a fourth in the bilateral oophorectomy group. Since over 90% of this group had a history of hormone replacement therapy use, the finding that years since bilateral oophorectomy was associated with increasing @entity731 conflicts with a well-known finding that such therapy reverses the adverse effect of bilateral oophorectomy on @entity301 .
