Postmortem diffusion of XXXX from the stomach.

@entity1 @entity167 @entity1068 @entity1042
We explored postmortem @entity1068 diffusion from the stomach using a @entity1 cadaver model with multiple blood site sampling. In all, 400 ml of @entity167 solution (5%, 10%, 20%, or 40% @entity1042 and @entity1068 weight/volume in water) was introduced into the stomach by oesophageal tube. Blood @entity1042 concentrations correlated with @entity1068 concentrations ( @entity1042 range, 1-676 mg%; @entity1068 range, 1-531 mg%; r = 0.9973). The pattern of @entity1068 diffusion showed marked between-case variability. Typically, concentrations were highest in pericardial fluid and, in decreasing order, in left pulmonary vein, aorta, left heart, pulmonary artery, superior vena cava, inferior vena cava, right heart, right pulmonary vein, and femoral vein. Diffusional flux was broadly proportional to the concentration of @entity1068 used. It was time-dependent (as assessed by 24-h and 48-h sampling) and markedly inhibited by refrigeration at 4 degrees C. After gastric instillation of 400 ml of 5% solution for 48 h at room temperature in paired cadavers, @entity1068 concentrations (mg%) were as follows: pericardial fluid 135, 222; aorta 50, 68; left heart 77, 26; right heart 41, 28; femoral vein 0. Using a 10% solution, @entity1068 concentrations (mg%) were as follows: pericardial fluid 401, 255; aorta 129, 134; left heart 61, 93; right heart 31, 41; femoral vein 5, 7. Introducing 50 ml of 10% @entity167 solution into the oesophagus after oesophagogastric junction ligation produced similar aortic blood @entity1068 concentrations. This suggests that postmortem gastrooesophageal reflux and diffusion from the oesophagus is the mechanism of artefactual elevation of aortic blood @entity1068 .(ABSTRACT TRUNCATED AT 250 WORDS)
