Defective cytokine production early after @entity1230 : Modulation in XXXX .

@entity1 @entity295 @entity5694 @entity310 @entity5 @entity4155 @entity1230 @entity379 @entity881 @entity688 @entity130
UNASSIGNED: The exact time frame of @entity1230 -induced immunosuppression and the immune mechanisms mediating transition to @entity295 are largely unknown. Peripheral blood mononuclear cells were isolated from 69 @entity1 with @entity1230 within the first 24h from injury and from 36 healthy volunteers and stimulated for cytokine production. Circulating endotoxins were measured by the kinetic LAL assay. Measurements were repeated the first 24h of @entity295 onset. @entity1 had defective responses for @entity5 necrosis factor-alpha ( @entity310 ), @entity688 , @entity4155 and @entity379 (IFNy) using a broad-panel of bacterial stimuli. Production of IFNy was pronounced for @entity1 with @entity130 -related @entity881 ( @entity881 ). Thirty-six @entity1 developed @entity295 . At that time, production of @entity310 was increased compared to baseline. The increase was greater among non-survivors than among survivors. Enhanced @entity310 production on @entity295 onset was a main finding of @entity1 without @entity5694 . Immunosuppression of both innate and adaptive cytokine responses appears as early as the first 24h from injury. Transition into @entity295 due to bacterial superinfection is accompanied by enhanced production of @entity310 and this is linked with unfavorable outcome.
