Neurotrophic Activity of Cultured Cell Line XXXX is Up-Regulated by @entity1521 -Rich Polypeptide Complex and Its Constituent Nonapeptide.

@entity1 @entity650 @entity179 @entity2252 @entity816 @entity8001 @entity1521 @entity528
UNASSIGNED: Neurotrophins such as nerve growth factor (NGF) and @entity2252 , as well as cytokines, for example, @entity650 ( @entity650 ) play an important role in neuroprotection and in the control of the central nervous system (CNS) function. Reduced expression of neurotrophic factors can lead to dysregulation of neuron function and @entity528 . There is also evidence for mutual interactions between neurotrophins and @entity650 . Therefore, the up-regulating the level of neuroprotective substances is one of the key manners to control the nervous system development and function. It can be a promising aim in the therapy of @entity179 in which the decreased level of neurotrophins is observed. In our recent studies, the role of @entity1521 -rich polypeptide complex (PRP) and its nonapeptide fragment (NP) in the regulation of neurotrophic activity in cultured astrocytes was shown. PRP and NP stimulate @entity1 @entity816 cell line @entity8001 to release the significant amounts of NGF to the extracellular space both in its precursor and mature form. We also provide the evidence that in NP-treated cells, the level of bNGF mRNA was increased. NP-treated cells used in this study produced also increasing amounts of @entity650 . This finding indicates that PRP and its nonapeptide fragment NP up-regulate neurotrophic activity of @entity8001 cell line by increase of NGF synthesis and its release into the extracellular space. It was also shown that NP-dependent increased production of @entity650 can enhance the NGF activity.
