Oral @entity3346 as empirical therapy for XXXX : a retrospective review.

@entity1 @entity323 @entity1095 @entity3346
OBJECTIVES: Anecdotal reports of increased libido and sexual function in @entity1 taking @entity3346 have led to its empirical use in @entity1 with @entity323 . A retrospective review of @entity1 -reported responses to @entity3346 was performed to outline the efficacy and side-effect profile of this agent. METHODS: Between 1989 and 1994, 182 @entity1 were placed on oral @entity3346 as empirical therapy for @entity323 . @entity1 ranged in age from 26 to 85 years, with a mean of 60 years. @entity1 were evaluated before receiving @entity3346 with a thorough medical history and physical examination. Known risk factors for @entity323 were assigned based on historical information and the findings of the examination. @entity1 received @entity3346 for at least 2 consecutive months, with daily doses starting at 25 mg. RESULTS: One hundred twenty-seven @entity1 were available for follow-up by a standardized questionnaire regarding perceived improvement in erectile function, sexual function, and side effects. In @entity1 less than 60 years of age, with no known risk factors for @entity323 , 21 of 27 (78%) showed significant improvement in erectile ability. Smokers and @entity1 older than 60 years with a history of significant @entity1095 responded poorly to @entity3346 therapy. The duration of @entity323 was inversely related to a response to @entity3346 . Of @entity1 with a duration of @entity323 less than 12 months, 48% reported a positive response. Only 16% of @entity1 with duration of @entity323 greater than 60 months reported improvement in erections and sexual function. @entity3346 was well tolerated by this population, with 62% reporting no side effects. CONCLUSIONS: Despite the limitations of a nonrandomized, retrospective study, @entity3346 appears to benefit younger @entity1 with @entity323 with few known risk factors. A prospective, placebo-controlled trial is needed to confirm the observations of this pilot study.
