Increased growth stimulation of @entity1 vascular cells by serum from @entity1 with primary XXXX .

@entity1 @entity753 @entity6340 @entity731 @entity165
Premature @entity731 in @entity753 @entity1 may be due, in part, to increased growth of vascular cells. Therefore, the growth stimulating effect of serum and serum fractions from @entity1 with primary @entity6340 (LDL- @entity165 : 7.5 +/- 1.7 mmol/l) and from healthy subjects on @entity1 arterial smooth muscle cells and fibroblasts has been investigated over 5-7 days in culture. @entity1 @entity753 sera increased the growth of both cell types up to a mean of 133% compared with normal sera (100%) (P less than 0.001). Removal of the dialyzable serum fraction (m.w. less than 3,500 daltons) reduced the growth effect of the @entity753 sera by 32% (P less than 0.001) and of the normal sera by 11% (P less than 0.01). Readdition of the @entity753 serum dialysate to its dialyzed serum restored completely the original growth effect. There was no significant difference in growth stimulation between the dialyzed @entity753 and normal sera excluding a major additional growth effect by LDL- @entity165 . The low molecular weight growth factor(s) of @entity753 serum (m.w. less than 3,500 daltons) showed a linear dependence of growth stimulation over a 20-fold concentration range. Increased amounts of this factor(s) might easily penetrate the arterial wall, thus contributing to atherogenesis.
