[Differentiation and function of XXXX monocytes].

@entity1 @entity5750 @entity3058 @entity4897 @entity2935 @entity8282 @entity6824 @entity3646 @entity2841
We found that @entity1 monocytes differentiate into macrophages (Mp) by @entity2841 and @entity6824 . The Mp induced by @entity2841 and @entity6824 are different in their morphology, @entity3058 expression and functions. In the course of that study, we found that @entity3646 modulate the differentiation of monocytes induced by @entity2841 and @entity6824 . @entity3646 alone did not induce the proliferation and differentiation of monocytes. @entity3646 , however, inhibited the proliferative response of monocytes to @entity2841 . When monocytes were incubated with @entity2841 and @entity3646 simultaneously, the cells recovered were non-adherent, non-phagocytic, and did not form rosette with EA. The cells were also negative in nonspecific esterase and showed an appearance of dendritic cells (DC). The DC-like cells expressed @entity4897 , DR, DQ and @entity2935 , but not @entity5750 , @entity8282 and 710F. The cells showed strong APC activity in alogeneic and autologous mixed lymphocyte reaction (MLR). When monocytes were incubated with @entity6824 and @entity3646 , TRAP positive multinucleated giant cells appeared. Taken together, these results suggest that @entity3646 is a principal factor that control the differential development of @entity1 monocytes into DC and multinucleated giant cells.
