Effects of @entity285 Consumption on Hepatocarcinogenesis in Japanese @entity1 With XXXX .

@entity1 @entity409 @entity157 @entity285 @entity99 @entity1068
BACKGROUND _ AIMS: The effect of @entity1068 consumption on hepatocarcinogenesis in @entity1 with @entity409 ( @entity409 ) is not clear. We aimed to investigate the influence of @entity285 consumption on hepatocarcinogenesis and determine the risk factors for @entity157 ( @entity157 ) in a large number of Japanese @entity1 with @entity409 without @entity99 . METHODS: This multicenter, retrospective cohort study was conducted at a specialized center for hepatology in Japan and included 9959 @entity1 with @entity409 without @entity99 , diagnosed by ultrasonography from January 1997 through December 2011. The @entity1 ' level of @entity1068 consumption was divided into 4 categories: <20 g/day (n  = 6671), 20-39 g/day (n  = 753), 40-69 g/day (n  = 1589), and >= 70 g/day (n  = 946). The primary endpoint was the onset of @entity157 . Statistical analyses performed included the Kaplan-Meier method and Cox proportional hazard analysis. The median follow-up period was 5.4 years. RESULTS: Of the study cohort, 49 cases (0.49%) developed @entity157 during the follow-up period. The annual incidence rate of @entity157 was 0.05% in @entity1 with @entity409 and a daily @entity1068 consumption <20 g/day. Increasing levels of @entity1068 consumption were associated with increased annual incidence rates of @entity157 : 0.06% for @entity1 with 20-39 g/day @entity1068 consumption (hazard ratio [HR], 1.54; 95% confidence interval [CI], 0.34-7.04), 0.16% for @entity1 with 40-69 g/day @entity1068 consumption (HR, 3.49; 95% CI, 1.50-8.12), and 0.22% for @entity1 with >= 70 g/day @entity1068 consumption (HR, 10.58; 95% CI, 5.06-22.13), compared with @entity1 with @entity1068 consumption <20 g/day. Multivariate analysis showed that @entity1068 consumption >= 40 g/day was an independent risk factor for @entity157 : for 40-69 g/day the HR was 2.48 (95% CI, 1.01-6.05; P  <  .047) and for >= 70 g/day the HR was 12.61 (95% CI, 5.68-28.00; P < .001). CONCLUSIONS: Based on a multicenter, retrospective analysis of almost 10,000 @entity1 with @entity409 , @entity1068 consumption >= 40 g/day is an independent risk factor for @entity157 .
