Epidemiological aspects of XXXX in Iran.

@entity13797 @entity1 @entity154 @entity227 @entity600 @entity299 @entity2419 @entity3384
@entity13797 , including @entity3384 with or without @entity2419 (CL (P)), are common @entity600 , second only to clubfoot in frequency of occurrence. The epidemiology and genetics of this disorder have been studied extensively in various countries by several investigators. The objective of this study is to assess the epidemiology and some genetic aspects of orofacial clefting at Imam Khomeini Hospital in Tehran. This study was a 7-year case series (retrospective) study from 1999 to 2006. The setting for the study was Imam Khomeini Hospital in Tehran, and the @entity1 were all consecutive surgical cases with @entity13797 referred to this hospital. One hundred and 77 cases of @entity3384 and/or @entity2419 were recorded during these 7 years. Seventy four of them (41.8%) were female and 103(58.2%) were male (M/F Ratio=1.39). Of all @entity1 , 40 @entity1 (22.6%) had isolated CP, 45 (25.4%) had @entity3384 without @entity2419 , and 92 (52%) had @entity3384 with @entity2419 ( @entity2419 ). Their M/F ratios were 1.66, 0.6 and 1.96 respectively. Of all CL (P) probands, 41 @entity1 (29.9%) were bilaterally affected. In unilateral cases, the left side was affected nearly twice as frequently as the right side. Among the @entity1 , 23 cases (13%) had other @entity600 ; most commonly head and @entity154 and then @entity299 . Fifty-four @entity1 (30.5%) had consanguine parents; 33 (18.6%) were first cousins, 7 (4%) were second cousins, and 14 (7.9%) were distant relatives. There was a positive family history for @entity2419 in 23 cases; most commonly CL-P. Our study reveals that the epidemiologic aspects of oral clefts in Iran are very similar to other Caucasian populations. It also suggests that a routine screening such as echocardiography and ruling out skeletal, hearing and @entity227 may be necessary in cleft @entity1 especially in @entity1 . It seems that genetic counseling and karyotyping can be very useful in @entity1 with multiple @entity600 .
