Role of the posterior capsule in the prevention of postoperative XXXX : experimental primate studies and clinical implications.

@entity231 @entity794 @entity737 @entity281 @entity3225
The posterior capsule has an important effect on the risk of postoperative @entity3225 . In order to investigate whether the posterior capsule inhibited the spread of infection into the vitreous we performed extracapsular @entity231 extraction in both eyes of 10 primates. In one eye of each primate the posterior capsule was left intact and in the other eye a large posterior capsulectomy was performed. When the anterior chambers were challenged with equivalent inocula of @entity794 , one of 10 eyes with an intact posterior capsule developed @entity281 . In contrast, nine of 10 eyes with a large posterior capsulectomy developed @entity281 . In a second experiment we investigated the effect of an intraocular lens on the barrier effect. Ten primates received extracapsular @entity231 extraction in both eyes and @entity737 . In one eye of each primate the posterior capsule was left intact and a J-loop monoplanar lens was implanted in the ciliary sulcus. In the other eye of each primate a large posterior capsulectomy was followed by implantation of a monoplanar, non-vaulted pseudophakos into the anterior chamber. None of the 10 eyes with a posterior capsule intact and a posterior chamber lens in place developed positive vitreous cultures or histopathological evidence of @entity281 . Thus the presence of a posterior chamber lens did not appreciably compromise the barrier effect of the intact posterior capsule. 40% of the eyes with a large posterior capsulectomy and a non-vaulted pseudophakos in the anterior chamber developed @entity281 , and 60% of the eyes showed histopathological evidence of @entity281 .
