[110-POS] : Salt sensitivity in the offspring of experimental preeclamptic and normotensive XXXX pregnancies.

@entity101 @entity3474 @entity1372 @entity71309 @entity551 @entity65
OBJECTIVES: Preeclampsia is a @entity101 disorder of pregnancy known to increase the risk of @entity65 in both mothers and offspring later in life. Offspring exposed to a suboptimal intrauterine environment during critical periods of growth may experience altered fetal programming and subsequent long term cardiovascular changes. The aim of this study was to investigate changes in vascular response in offspring from experimental preeclamptic (EPE) compared to normotensive @entity3474 pregnancies (controls), following a high salt diet challenge. METHODS: After one week of baseline measurements on a standard diet, animals were fed a high salt diet for two weeks. @entity551 (SBP, @entity71309 ) were measured and urinary @entity1372 assessed in offspring from EPE (n=6) and controls (n=6). A generalized linear model was performed to compare BP between the two groups at both baseline and day 14, adjusted for current age. Data is reported as the mean  standard error. Significance was set at P<0.05. RESULTS: At baseline there were no differences between the groups for SBP (P=0.89) and @entity71309 (P=0.38). After salt loading the EPE group had significantly higher SBP (92  5mmHg) compared to the control group (83  4 mmHg, P=0.03). There was no significant difference in @entity71309 between the two groups (P=0.10). There was no difference in urinary @entity1372 excretion between groups (average for both groups 30mmol/day). CONCLUSIONS: Offspring from EPE pregnancies had significantly higher blood pressure after a two week salt challenge, compared with controls. Salt sensitivity may differ in offspring from @entity101 pregnancies due to fetal programming. This could have long term consequences for cardiovascular health of EPE offspring. Further research is required to determine exact mechanisms. DISCLOSURES: K.R. Yeung: None. S.M. Lim: None. S. Heffernan: None. S. Pears: None. J.M. Lind: None. A. Hennessy: None. A. Makris: None.
