Pregnancy outcome and progression of XXXX . What's next?

@entity1 @entity8 @entity6 @entity2316 @entity4053 @entity164 @entity1011
OBJECTIVES: The first objective was to assess the association of renal function with maternal and fetal pregnancy outcome in @entity1 with @entity2316 . The second objective was to examine the feasibility of a multicenter surveillance program to determine the rates of maternal and fetal pregnancy complications in @entity1 with @entity2316 , and to study the effect of pregnancy on the natural history of @entity2316 . METHODS: In order to address the first objective, we analyzed data from @entity1 with @entity164 1 @entity6 and @entity8 enrolled in the @entity6 in Pregnancy Program at our institution. @entity1 were assigned to one of three groups according to enrolment serum @entity1011 concentration: < or = 1.0 mg/dl, > 1.0 to 1.5 mg/dl and > 1.5 mg/dl. A pilot surveillance program at six centers included @entity1 experiencing pregnancy complicated by @entity2316 . In both studies, medical and obstetric history, and maternal and neonatal outcomes, were recorded. Statistical analysis included chi2, logistic regression and analysis of variance. RESULTS: There were 72 pregnancies in 58 @entity1 with @entity2316 who enrolled in the pregnancy program. High serum @entity1011 concentration at enrolment was associated with delivery before 32 weeks' gestation, very low birth weight and increased incidence of @entity4053 , independent of quantity of total urinary protein excretion and glycemic control in any trimester. To date, pilot surveillance data have been obtained from six centers on 16 women. Serum @entity1011 concentrations ranged from 0.4 to 1.1 mg/dl and @entity1011 clearance from 32 to 317 m/min. Gestational age at delivery ranged from 22 to 39 weeks. CONCLUSIONS: High serum @entity1011 concentration at enrolment is a risk factor for adverse maternal and neonatal outcome, independent of quantity of total urinary protein excretion and glycemic control during any trimester. A multicenter surveillance program is needed, in order to study less frequent maternal and neonatal outcomes as well as the long-term effects of pregnancy on the natural course of @entity2316 .
