Normalization of structural cardiovascular changes during antihypertensive treatment with a regimen based on the ACE-inhibitor XXXX .

@entity1 @entity101 @entity2514 @entity4346 @entity4768 @entity13520 @entity65 @entity4687
Untreated essential @entity101 is associated with @entity4346 ( @entity4346 ) and structural changes in resistance vessels. The aim of this study was to establish the effect of @entity4687 based antihypertensive therapy on media thickness to lumen diameter (media:lumen) ratio of peripheral resistance vessels and left ventricular mass in essential @entity101 . Twenty-five @entity1 with newly diagnosed or poorly regulated essential @entity101 were treated with @entity4687 . Insufficient treatment response ( @entity13520 > 90 mmHg) led to addition of @entity4768 , and @entity2514 was used as a tertiary drug if necessary. Gluteal subcutaneous biopsies were taken surgically at baseline and after 9 months of successful treatment. Two small resistance arteries were isolated and mounted in a small vessel myograph, and media:lumen ratio (%) was measured under standardized conditions. Left ventricular mass was determined by echocardiography. Mean (SD) media:lumen ratio decreased from 9.8 (2.6) % to 7.8 (1.9) % (p < 0.05), while left ventricular mass decreased from 299 (75) g to 199 (53) g (p < 0.001). Correlation was found between changes in left ventricular mass index and media:lumen ratio (r = 0.62, p < 0.01). It is concluded that a @entity4687 based regimen efficiently normalizes resistance artery structure and @entity4346 in essential @entity101 within one year of treatment. The impact of these findings on the excess @entity65 and mortality in @entity101 remains to be investigated.
