[ XXXX . Physiopathologic, clinical, histological, and therapeutic features].

@entity32 @entity500 @entity409 @entity205 @entity4754 @entity3851 @entity99 @entity617 @entity775
@entity775 is characterized by an @entity32 of the portal tract with lymphocytes and plasma cells, an @entity4754 and a variety of circulating autoantibodies. The presence of smooth muscle antibodies and/or antinuclear antibodies define type 1. Type 2 is characterized by the presence of liver-kidney--microsomal antibodies. Environmental, genetic and infectious factors may explain the autoreactivity of T cells. Different non specific clinical features may be present. Sometimes the presentation may be an acute @entity99 ; in the remainder, the disease may not be recognized until @entity409 is advanced. @entity4754 and presence of circulating autoantibodies are the key for diagnosis. The association of @entity617 in combination with @entity500 remains the established treatment. If relapse or non response occur, other immunosuppressive therapy such as @entity205 may be useful. Liver transplantation is reserved for (sub)fulminant forms and @entity3851 .
