Circulating Glial-derived neurotrophic factor is XXXX .

@entity6352 @entity1 @entity308 @entity3831 @entity1316 @entity915
BACKGROUND: The @entity6352 ( @entity6352 ) is part of the TGF-b superfamily and is abundantly expressed in the central nervous system. Changes in @entity6352 homeostasis have been reported in @entity1316 . AIM: To assess serum @entity6352 concentration in elderly subjects with late-life @entity308 , before antidepressant treatment, as compared to healthy elderly controls. METHODS: Thirty-four elderly subjects with @entity308 and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of @entity308 was ascertained by the @entity915 interview for DSM-IV and the severity of @entity308 symptoms was assessed by the Hamilton Depression Rating Scale ( @entity3831 -21). Serum @entity6352 concentration were determined by sandwich ELISA. RESULTS: @entity1 with @entity308 showed a significant reduction in @entity6352 levels as compared to healthy elderly controls (p < 0.001). Also, @entity6352 level was negatively correlated with @entity3831 -21 scores (r = -0.343, p = 0.003). DISCUSSION: Our data provide evidence that @entity6352 may be a state marker of @entity308 in older adults. Changes in the homeostatic control of @entity6352 production may be a target to development of new antidepressant strategies.
