Clinico-immunological changes post-immunotherapy with XXXX .

@entity1 @entity566 @entity565 @entity564 @entity2490 @entity379 @entity3646
BACKGROUND: Cockroach proteins induce @entity566 including @entity565 in predisposed individuals. Well-designed controlled studies are required to show the effect of cockroach immunotherapy (IT). This study is aimed to assess changes in clinical and immunological parameters post-IT with @entity564 extract. MATERIALS AND METHODS: A double-blind, placebo-controlled trial of cockroach IT was performed for 1year in 50 @entity1 of @entity565 , @entity2490 or both. The efficacy of IT was assessed by change in skin reactivity and clinical parameters such as symptom/drug score, airway reactivity and immunological parameters namely IgE, IgG1 and IgG4, @entity3646 and @entity379 by enzyme-linked immunosorbent assay and western blotting using @entity1 ' sera at baseline and after 1year of treatment. RESULTS: Immunotherapy with cockroach extract demonstrated significant improvement in clinical parameters of active group @entity1 compared with baseline values and placebo group. Specific IgE levels showed a modest reduction, while IgG4 levels increased significantly in active IT group after 1year. IgE immunoblotting demonstrated reduction in intensity and number of specific bands, whereas IgG4 binding showed more number and distinct bands following IT. Active group @entity1 showed correlation between increase in IgG4/IgG1 ratio and reduction in symptom score post-IT. CONCLUSIONS: Immunotherapy with cockroach extract improved clinical and immunological status of @entity565 and @entity2490 @entity1 . Clinical improvement in @entity1 after IT is associated with immunological changes.
