Effects of structured exercise and pharmacotherapy vs. pharmacotherapy for adults with XXXX : A randomized clinical trial.

@entity1 @entity308 @entity148 @entity1605
OBJECTIVE: Physical exercise has been consistently documented as a complementary therapy in the treatment of @entity308 . However, despite a higher prevalence among @entity1 compared to @entity1 , the trials developed in @entity1 are scarce. In addition, the optimal dosage of exercise capable of producing benefits that reduce @entity308 remains unclear. This clinical trial is designed to measure the effect of a structured physical exercise program as a complement to antidepressant medication in the treatment of @entity1 with @entity308 . METHODS: From July 2013 to May 2014, we implemented a randomized controlled trial (HAPPY BRAIN study). A total of 26 @entity1 (aged 50.16      12.08) diagnosed with clinical @entity308 were randomized either to a supervised aerobic exercise group (45-50  min/week three times a week for four months) plus pharmacotherapy (intervention group), or only antidepressant medication (control group). RESULTS: The exercise group presented a decrease in BDI-II and DASS-21 total score scales. Relatively to DASS-21, it showed a significant decrease in @entity148 and stress. The exercise group when compared to a control group showed improvement in relation to physical functioning parameters between baseline and post-intervention. Moreover, anthropometric parameters presented only significant differences between groups in fat mass percentage. Nonetheless, no differences were found between groups in weight, body mass index, waist circumference, and self-esteem. CONCLUSION: Our results showed that supervised structured aerobic exercise training could be an effective adjuvant therapy for treating @entity1 with @entity308 , reducing depressive symptomatology and improving physical fitness. A key factor of this improvement included strict control of exercise workload parameters and adjustment to each subject's capacity. In our study, due to the sample size there is an increase in the probability of @entity1605 .
