Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for XXXX .

@entity1 @entity410 @entity353 @entity1315 @entity302 @entity2414
BACKGROUND AND PURPOSE: Mesial temporal structures play an important role in @entity1 memory. In @entity1315 ( @entity1315 ), @entity410 activity is generated from the same structures. Surgery is the definitive treatment for medically intractable @entity1315 . In addition to standard temporal lobe microsurgical resection, stereotactic radiofrequency amygdalohippocampectomy (SAHE) is used as an alternative @entity1315 treatment. While @entity2414 after @entity302 surgery are well known, it has been shown that memory decline is not a feature of SAHE. The aim of the present study was to correlate the volume of the remnant hippocampus and amygdala in @entity1 treated by SAHE with changes in memory parameters. MATERIALS AND METHODS: Thirty-seven @entity1315 @entity1 treated by SAHE (ten right, 27 left) were included. @entity1 underwent magnetic resonance imaging examinations including hippocampal and amygdalar volumetry and neuropsychological evaluation preoperatively and 1 year after surgery. RESULTS: Using Spearman correlation analyses, larger left-sided hippocampal reductions were associated with lower verbal memory performance (  =-0.46; P=0.02). On the contrary, improvement of global memory quotient (MQ) was positively correlated with larger right-sided hippocampal reduction (  =0.66; P=0.04). Similarly, positive correlations between the extent of @entity2414 (  =0.74; P=0.02) and global MQ change (  =0.69; P=0.03) were found. Thus, larger right hippocampal and @entity353 was associated with higher global and verbal MQ change after SAHE. CONCLUSION: Larger left-sided hippocampal reductions were associated with lower verbal memory performance. This finding is in accordance with the material-specific model of @entity1 memory, which states that the dominant hemisphere is specialized for the learning and recall of verbal information. We hypothesize that larger right-sided ablations enable the left temporal lobe to support memory more effectively, perhaps as a consequence of @entity302 spreading from remnants of right mesiotemporal structures to the left.
