The Pathophysiology of XXXX Formation and Expansion.

@entity1 @entity548 @entity1410 @entity397 @entity1779
UNASSIGNED: @entity1779 is a devastating disease. Despite its clinical importance, the pathophysiology of @entity1779 is not well understood. @entity1410 expansion occurs in a large subset of @entity1 and is a predictor of poor outcomes. Since @entity1410 growth provides a potential opportunity for therapeutic intervention, a thorough understanding of its biological mechanisms is of key importance. After vessel rupture, an initial @entity1410 forms. Following this initial phase, accumulating evidence suggests that the mass effect causes secondary vessel rupture, which contributes to the @entity1410 and may trigger an @entity397 . The circumstances under which this occurs and to what extent secondary @entity548 contributes to final @entity1410 volume remain unknown, however. To address these questions, a translational approach seems most suitable. Current experimental models include intracranial injections of collagenase or autologous blood. Each has individual strengths and weaknesses in its ability to simulate @entity1 @entity1779 . The ultimate goal for improved understanding and modeling of the pathophysiology of @entity1410 expansion is to identify new treatment approaches.
