The influence of XXXX on both normal and raised intracranial pressure of artificially ventilated animals.

@entity1707 @entity548 @entity428 @entity33796 @entity3652
The effect of two different doses of @entity3652 , 0.5 mg kg-1 body weight, and 2.0 mg kg-1 body weight, on intracranial pressure and cerebral perfusion pressure were investigated in 21 young @entity1707 (26-34 kg) under controlled artificial ventilation. Three groups each containing seven animals were studied: Group 1. Initially normal blood pressure and an intracranial pressure within the normal range (10.7 mmHg). Group 2. Normal blood pressure and @entity428 caused by inflating an epidural balloon (29.2 mmHg). Group 3. @entity428 (32.7 mmHg) and mean arterial pressure reduced by approximately 30% through controlled @entity548 . There was no increase in intracranial pressure from either normal or initially increased values. This applied to animals with normal blood pressure values and also to those in @entity548 . This observation can be explained by the lack of an increase in @entity33796 under controlled ventilation. During @entity548 cerebral perfusion pressure fell significantly as a result of the fall in mean arterial pressure. This particularly applied to the 2.0 mg kg-1 dose of @entity3652 . We therefore consider volume substitution to be essential in this situation.
