Maintenance tocolysis with XXXX in threatened @entity3152 : 2-year follow up of the offspring in the APOSTEL II trial.

@entity1 @entity3152 @entity245 @entity397 @entity594
OBJECTIVE: To evaluate long-term effects of maintenance tocolysis with @entity594 on neurodevelopmental outcome of the @entity1 . DESIGN, SETTING AND POPULATION: Follow up of @entity1 of @entity1 who participated in a multicentre randomised controlled trial on maintenance tocolysis with @entity594 versus placebo. METHODS: Two years after the APOSTEL II trial on maintenance tocolysis with @entity594 versus placebo, we asked @entity1 to complete the Ages and Stages Questionnaire. MAIN OUTCOME MEASURES: @entity1 development was measured in five domains. @entity245 was defined as a score of  <=1 SD in one or more developmental domains. We performed exploratory subgroup analysis in @entity1 with preterm prolonged @entity397 of the membranes, and in @entity1 with a cervical length <10  mm at study entry. RESULTS: Of the 276 @entity1 eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 @entity1 . At 2  years of age, @entity1 of @entity1 with @entity594 maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P  =  0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P  =  0.04). CONCLUSIONS: This follow-up study revealed no clear benefit of @entity594 maintenance tocolysis at 2  years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time. TWEETABLE ABSTRACT: No clear benefit of @entity594 maintenance tocolysis in @entity3152 on 2-year @entity1 outcome.
