Effect of early @entity4688 therapy on left ventricular function and structure in XXXX .

@entity1 @entity4688 @entity296 @entity1289 @entity384 @entity2554 @entity1188 @entity583 @entity1002
@entity1188 expansion starts within hours to days after transmural @entity296 . Previous echocardiographic and left ventriculographic studies demonstrated that @entity1289 ( @entity1289 ) inhibitor therapy limits left @entity2554 , particularly in @entity1 with anterior wall @entity583 ( @entity583 ) or @entity1002 . Forty-three @entity1 with an acute Q-wave @entity583 were randomized within 24 hours of symptom onset to intravenous enalaprilat (1 mg) or placebo. @entity1 were then given corresponding oral therapy and followed for 1 month. Predrug and 1-month gated blood pool scans were obtained in 32 @entity1 to evaluate changes in cardiac volumes and ejection fraction. Twenty-three @entity1 underwent magnetic resonance imaging at 1 month to evaluate left ventricular @entity1188 expansion. Blood pressure decreased at 6 hours but returned to baseline in both groups after 1 month of therapy. The change in cardiac volumes from baseline to 1 month differed between the placebo (end-diastolic volume +16 +/- 5 ml, end-systolic volume +8 +/- 6 ml), and @entity4688 (end-diastolic volume -8 +/- 9 ml and end-systolic volume -14 +/- 7 ml) groups (p < 0.05 vs placebo). Global and @entity1188 zone ejection fractions improved significantly at 1 month in the @entity4688 group (+6 +/- 3% and 19 +/- 5%, respectively) but did not change over 1 month in the placebo group. @entity1188 and @entity1188 expansion index by magnetic resonance imaging were significantly less in those treated with @entity4688 , suggesting less @entity1188 expansion in this group. Thus, early administration of enalaprilat to @entity1 presenting with a first Q-wave @entity583 prevents @entity384 and @entity1188 expansion.
