Crotalaria-induced @entity120 . Uptake of XXXX by the cells of the pulmonary circulation and alveolar walls.

@entity894 @entity8025 @entity1184 @entity1373 @entity120 @entity665 @entity358 @entity35
Feeding with Crotalaria spectabilis seeds induces structural changes in the pulmonary arterial circulation characteristic of @entity120 : increased medial and adventitial thickness, the appearance of muscle in smaller arteries than normal, and reduction in the number of peripheral arteries. By autoradiographic techniques, after injection of @entity665 into @entity35 fed Crotalaria for 3, 7, 14, 21, 28, or 35 days, the contribution of @entity1373 to these changes has been assessed at two levels of the pulmonary artery--the hilum and the periphery. In the @entity358 , a biphasic increase in @entity894 ( @entity894 ) is seen in each cell type. After 3 days of feeding, the medial smooth muscle cells show a slight but significant increase (1.5 times the control value), and, after 7 days, so do the adventitial fibroblasts (3 x) and the endothelial cells (EC) (2 x). After 14 days @entity894 for all three cell types is again at control values, but after 21 days (wall thickness is no increased) each cell type shows at least a fivefold increase; by 35 days all are again near control levels. In the intra-acinar region, by 14 days, "newly" muscularized arteries are identified and increase in number and proportion up to 35 days; @entity665 uptake is not evident in this cell type until 35 days have passed. The ECs of these arteries, however, show a striking increase in @entity894 after 14 days as do those of the @entity8025 . The ECs of the intra-acinar veins show a biphasic response being increased after 7, 28, and 35 days. The present study has shown that Crotalaria ingestion induces @entity1373 and @entity1184 of pulmonary arterial cells at pre- and intra-acinar levels. The early increase in @entity894 probably represents a response to the original cell injury, the later changes, a response to continuing damage or, in part, adaptation to the @entity120 now present.
