Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve XXXX score to excised aortic valve weight.

@entity1 @entity101 @entity6 @entity460 @entity453 @entity472
AIMS: Calcific @entity472 ( @entity472 ) is purportedly associated with less @entity460 burden in @entity1 than in @entity1 . We sought to examine sex-related differences and correlates of surgically excised aortic valve weight (AVW) in pure @entity472 . METHODS AND RESULTS: Clinical and echocardiographic characteristics of 888 consecutive @entity1 who underwent aortic valve replacement for severe @entity472 were correlated to AVW, and in 126 @entity1 , AVW was also correlated to computed tomography aortic valve @entity460 (AVC) score. @entity1 and @entity1 had similar indexed valve area (0.42    0.09 vs. 0.42    0.07 cm (2)/m(2), P = 0.95) and mean systolic gradient (53    15 vs. 52    13 mmHg, P = 0.11), but @entity1 had higher New York Heart Association class (2.63    0.70 vs. 2.50    0.70, P = 0.01) and less prevalent @entity453 (38 vs. 52%, P < 0.0001). Aortic valve weight was lower in @entity1 (1.94    0.88 vs. 3.08    1.32 g, P < 0.0001) even when indexed to body surface area (1.09    0.48 vs. 1.48    0.62 g/m(2), P < 0.0001) or left ventricular outflow tract (LVOT) area (0.54    0.23 vs. 0.71    0.29 g/cm(2), P < 0.0001). Using multivariate analysis, male sex (P < 0.0001), bicuspid valve (P < 0.0001), and larger LVOT area (P < 0.0001) were the major determinants of increased AVW, along with current cigarette smoking (P = 0.007). @entity6 (P = 0.004) and @entity101 (P = 0.03) were independently associated with lower AVW. Aortic valve @entity460 correlated well with AVW (r = 0.81, P < 0.0001) and was lower in @entity1 than in @entity1 (2520    1199 vs. 3606    1632 arbitrary units, P < 0.0001). CONCLUSIONS: Despite the same degree of @entity472 severity, @entity1 have less AVC and lower AVW compared with @entity1 , irrespective of valve morphology. Aortic valve @entity460 is correlated to excised AVW. @entity101 , @entity6 , and current cigarette smoking were independently associated with AVW.
