Systematic review of randomized trials for the treatment of XXXX .

@entity1 @entity4878 @entity2066 @entity8407 @entity5 @entity904 @entity1732 @entity12120 @entity1141
@entity8407 is a relatively common oral lesion that, in a varying proportion of cases, undergoes malignant transformation. The aim of this review was to assess the effectiveness of treatments for @entity12120 . Randomized controlled trials (RCTs) enrolling @entity1 with a diagnosis of @entity8407 were identified by searching biomedical databases, hand-searching relevant oral medicine journals, and contacting oral medicine experts through a European mailing list. The methodological quality of included studies was assessed on the basis of the method of allocation concealment, blindness of the study, and loss of @entity1 . Data were analyzed by calculating relative risk. @entity5 , demonstrated by histopathological examination, was the main outcome considered. Secondary outcomes included clinical resolution of the lesion and variation in @entity1141 severity. Six RCTs were included in the review. @entity904 and @entity4878 were tested in four RCTs; the other agents tested were @entity1732 , mixed tea, and beta carotene. Malignant transformation was recorded in just two studies: none of the treatments tested showed a benefit when compared with placebo. Treatment with @entity2066 and @entity904 or @entity4878 was associated with better rates of clinical remission, compared with placebo or absence of treatment. Whenever reported, a high rate of relapse was a common finding. Side effects of variable severity were often described; however, interventions were well accepted by @entity1 since drop-out rates were similar between treatment and control groups. It is noteworthy that the possible effectiveness of surgical interventions, including laser therapy and cryotherapy, has apparently never been studied by means of an RCT. To date, in conclusion, there is no evidence of effective treatment in preventing @entity5 . Treatments may be effective in the resolution of lesion; however, relapses and adverse effects are common.
