Alteration of connexin expression is an early signal for XXXX .

@entity32 @entity16899 @entity82 @entity8 @entity101 @entity43173 @entity1750 @entity1695 @entity19 @entity740 @entity44470 @entity6580 @entity631
@entity740 is promoted by a variety of factors that induce @entity32 and @entity82 . @entity32 and excessive scaring have been recently associated with disruptions of the gap junction-mediated intercellular communication. Nevertheless, little is known about alterations of the expression of gap junction proteins such as connexin (Cx) 43 and 37 in @entity740 . In this study, we investigated the expression of these two Cxs in the @entity101 RenTg mice, the anti-glomerular basement membrane @entity631 , and the unilateral @entity1695 models, all leading to the development of @entity740 in @entity19 . Expression of @entity16899 was almost negligible in the renal cortex of control @entity19 . In contrast, @entity16899 was markedly increased in the endothelium of peritubular and glomerular capillaries of the 3-mo-old RenTg @entity19 , in the glomeruli of @entity19 suffering from @entity631 , and in the tubules after obstructive @entity8 . The @entity16899 expression pattern was paralleled closely by that of the adhesion markers such as @entity44470 as well as the inflammatory biomarker @entity1750 . In contrast, @entity43173 that was abundantly expressed in the renal cortex of healthy @entity19 was markedly decreased in the three experimental models. Interestingly, @entity16899 +/- @entity19 showed restricted expression of @entity6580 after 2 wk of obstructive @entity8 . These findings suggest the importance of Cxs as markers of @entity740 and indicate that these proteins may participate in the inflammatory process during the development of this pathology.
