A novel soy-based meal replacement formula for XXXX among @entity28 individuals: a randomized controlled clinical trial.

@entity1 @entity165 @entity353 @entity28
OBJECTIVE: To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of @entity28 . DESIGN: A 12-week prospective randomized controlled clinical trial. SETTING: Outpatient weight control research unit. SUBJECTS: One @entity28 (28<BMI<or=41 kg/m(2)) volunteers between the ages of 35 and 65 y. Seventy-four @entity1 completed the trial. INTERVENTION: @entity1 were randomized to either the meal replacement treatment group (n=50; 240 g/day, 1200 kcal/day) or control group (n=50). Both groups at baseline received a single dietary counseling session and a pamphlet describing @entity353 practices. MAIN OUTCOME MEASURES: Weight, body fat, serum lipid concentrations. RESULTS: : By intent-to-treat analysis, the treatment group lost significantly more weight than the control group (7.00 vs 2.90 kg; P<0.001) and had a greater change in total (22.5 vs 6.8 mg/dl; P=0.013) and LDL @entity165 (21.2 vs 7.1 mg/dl; P<0.009). Among completers only, the treatment group again lost more weight (7.1 kg; n=37 vs 2.9 kg; n=37; P=0.0001) and had a greater reduction in total @entity165 (26.1 mg/dl; n=37 vs 6.7 mg/dl; P=0.0012) and a greater change in LDL @entity165 (21.6 vs 5.5 mg/dl; P=0.0025). (For any given degree of @entity353 , the reduction in LDL @entity165 was significantly greater in the treatment group.) Treatment was well tolerated and no serious side effects were detected. CONCLUSIONS: Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL @entity165 beyond what could be expected given the weight lost.
