Enhanced Dendroaspis natriuretic peptide immunoreactivity in experimental XXXX .

@entity35 @entity6708 @entity1372 @entity1695
Whether the postobstructive diuresis can in part be related to an altered regulation of Dendroaspis natriuretic peptide (DNP) was investigated. Male @entity35 were bilaterally obstructed of their ureters. Control group was with sham @entity1695 . Forty-eight h later, tissue levels of DNP immunoreactivity were determined in the plasma, heart, and kidneys. Urine samples were collected in some @entity35 under anesthesia. The plasma DNP immunoreactivity was significantly increased by 45% in the experimental group. The tissue levels of DNP immunoreactivity in the atrium, ventricle, or kidneys did not significantly differ between the experimental and control groups. The urinary flow and @entity1372 excretion rate were 3- to 4-fold increased in the experimental group. The urinary DNP excretion was also increased in the experimental group, which was positively correlated with the urinary volume and @entity1372 excretion. The urinary excretion of @entity6708 was 2- to 3-fold increased in the experimental group. These results indicate that an enhanced DNP activity may in part be causally related to the postobstructive diuresis.
