Endothelial Progenitor Cells Predict Cardiovascular Events after XXXX and Acute @entity583 . A PROCELL Substudy.

@entity1 @entity1187 @entity64 @entity63 @entity731 @entity453 @entity583 @entity204 @entity121
INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute @entity583 (AMI) or @entity64 ( @entity64 ). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 @entity64 @entity1 were consecutively studied in three Spanish centres. @entity1 with previously documented @entity453 or @entity63 strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. @entity1 were followed for up to 6 months. NVE was defined as new @entity1187 , transient @entity63 attack (TIA), @entity64 , or any hospitalization or @entity204 from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid @entity121 ( @entity121 ), @entity731 burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 @entity1 (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 @entity204 ). Vascular events were associated with age (P = 0.039), carotid @entity121 >= 0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and @entity121 >= 0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and @entity121 >= 0.9 can predict future vascular events in @entity1 with AMI and @entity64 , but CEC count does not affect cardiovascular risk.
