XXXX production with @entity1468 .

@entity1 @entity2232 @entity5935 @entity3542 @entity1507 @entity4770 @entity1468 @entity842 @entity57392 @entity1011
OBJECTIVE: To clarify production of @entity842 with @entity1468 . METHODS: Production of @entity842 and elimination of its metabolites, @entity3542 and @entity1507 , determines ultimately the level of those metabolites in plasma of subjects whose diets lack them. We measured simultaneously plasma levels and renal clearance of @entity3542 and @entity1507 in 20 @entity1 with @entity1468 and in 21 healthy pregnant @entity1 . Fifteen preeclamptic gravidas were receiving antihypertensive medication and five received betamethasone 1-4 days before the study. Subjects were prescribed low @entity3542 and @entity1507 diets for 24 hours and fasted overnight before collection of plasma and urine samples. @entity3542 and @entity1507 were measured spectrophotometrically by Griess reaction. RESULTS: Preeclamptic @entity1 had significantly higher plasma levels of @entity3542 and @entity1507 (18.1+/-6.2 micromol/L versus 13.0+/-4.3 micromol/L, mean+/-standard deviation [SD], P = .009), which because renal clearance did not differ (0.6+/-0.3 versus 0.7+/-0.3 mL/s), indicated increased production of @entity842 with @entity1468 that was unaffected by antihypertensives or @entity5935 . The mean plasma level of @entity2232 was increased (5.1+/-1.4 versus 3.6+/-1.0 pg/mL, P < .001), and urinary output of the @entity4770 metabolite @entity57392 was decreased (39.1+/-18.0 versus 61.3+/-35.6 ng/mmol @entity1011 , P = .019) with @entity1468 . These two endothelial markers showed no relation to plasma @entity3542 and @entity1507 . CONCLUSION: @entity842 production was increased with @entity1468 . The biologic significance of increased production is unknown, but it might be compensation for the vasoconstriction of @entity1468 .
