Mutagenic effects of XXXX on @entity19 somatic cells in vivo.

@entity1 @entity71048 @entity57352 @entity19 @entity5244 @entity5600 @entity7044 @entity238
The mutagenic activity of @entity71048 ( @entity57352 ) was evaluated in the micronucleus test in @entity19 . A clear clastogenic effect was obtained at all concentrations studied (0.2-1.0 mmole/kg body weight). The maximum number of micronuclei occurred 24 h after a single intraperitoneal (i.p.) injection. The time-course for the @entity57352 -induced micronuclei was in agreement with the available data on the rapid excretion of @entity5600 from the @entity1 body. The dose-effect response was best described by a linear equation with a logarithmic component. The emergence of the latter term was related to the toxic effects of @entity57352 at higher concentrations on bone marrow erythropoietic function. A comparison of the effects induced by @entity57352 and by @entity7044 indicated that @entity57352 cannot be considered a strong mutagenic compound. We have compared the sensitivity of the @entity19 micronucleus test and that of @entity238 dominant-lethal test by contrasting the effects obtained at similar exposure doses. This comparison leads to the conclusion that the micronucleus test is capable of responding to far lower @entity5244 concentrations than the @entity238 dominant-lethal mutation test. Our results testify to the ability of @entity71048 to cause genotoxic damages in vivo in both somatic and germinal cells of higher organisms. Thus, the chemical in question may be of potential genetic hazard to @entity1 .
