Fibrinolytic response to XXXX and fibrin fragment D-dimer levels in normal and complicated pregnancy.

@entity1 @entity851 @entity6 @entity1723 @entity1468 @entity432 @entity3479
The fibrinolytic response to @entity432 was assessed in 29 @entity1 with normal or complicated pregnancy, by measurements of total @entity3479 and free @entity3479 with specific ELISAs. The release of @entity3479 from the vessel wall was 11 +/- 9 ng/ml in non-pregnant @entity1 (mean +/- SD, n = 6) but was markedly reduced throughout pregnancy. Following @entity432 , free @entity3479 increased by 12 +/- 11 ng/ml in non-pregnant @entity1 but remained below the detection limit of 2 ng/ml towards the end of pregnancy. A markedly reduced @entity3479 release with absence of free @entity3479 was also observed during late pregnancy in @entity1 with @entity1723 , @entity851 and @entity1468 . Plasma levels of fragment D-dimer of cross-linked fibrin were measured with a specific ELISA in 79 pregnant @entity1 . D-dimer levels were 129 +/- 36 ng/ml (mean +/- SD, n = 8) in non-pregnant @entity1 and increased to 400 +/- 170 ng/ml (n = 25) and 440 +/- 220 ng/ml (n = 22) during the second and third trimester of pregnancy respectively. Significantly higher levels than observed in uncomplicated third trimester pregnancies were found in 3 out of 6 @entity6 and in 2 out of 7 pre-eclamptic @entity1 . It is concluded that the @entity3479 release after @entity432 is significantly reduced during pregnancy. In addition, released @entity3479 is rapidly inhibited. The levels of fragment D-dimer increase during pregnancy, suggesting that, notwithstanding the marked impairment of the fibrinolytic response to @entity432 , the fibrinolytic system remains functionally active.
