Prevalence and correlates of XXXX in systemic sclerosis--results from the UCLA scleroderma quality of life study.

@entity1 @entity308 @entity304 @entity102 @entity74 @entity158 @entity717 @entity25
OBJECTIVE: @entity74 are associated with @entity25 . This study examines @entity25 correlates in @entity1 with SSc. METHODS: @entity1 are 180 SSc @entity1 in an observational study. At baseline, @entity1 completed the Medical Outcomes Study Sleep measure (MOS-Sleep scale). In addition, @entity1 were administered other @entity1 -reported outcome (PRO) measures including the 36-item short form (SF-36), @entity717 index (HAQ-DI), Functional Assessment of @entity102 Therapy-Fatigue (FACIT-Fatigue), @entity308 ( @entity308 ) scale and a University of California at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Questionnaire (UCLA SCTC GIT 2.0). Descriptive statistics were assessed for six scales of MOS-Sleep and the 9-item sleep problem index (SLP-9; a composite index). We computed Spearman's rank-order correlations between the MOS-Sleep scales and the HAQ-DI, FACIT-Fatigue, @entity308 , SSc-SCTC GIT 2.0 and SF-36 scales. In addition, we developed a regression model to assess predictors of SLP-9 scores. Covariates included demographics, physician variables of disease severity and @entity1 -reported variables of worsening symptoms and the PRO measures. RESULTS: SSc @entity1 reported a mean (s.d.) of 7.1 (1.73) h of sleep a night. @entity1 reported worse scores on four of six scales (except for snoring and sleep quantity) compared with the US general population (P < 0.001). SLP-9 was correlated with @entity158 and dyspnoea over the past 1 month, reflux scale of the UCLA SCTC GIT 2.0, @entity308 and FACIT-Fatigue (   0.26-0.56). In the stepwise multivariate regression model, the @entity308 , worsening dyspnoea and reflux scale were significantly associated with SLP-9 index. CONCLUSION: Sleep disturbances are common in SSc and are associated with worsening dyspnoea, @entity308 mood and severity of @entity304 .
