Association of Sleep Disordered Breathing with Wake-Up Acute XXXX : A Full Polysomnographic Study.

@entity1 @entity64 @entity1353 @entity27 @entity412 @entity385
STUDY OBJECTIVES: Sleep disordered @entity1353 (SDB) is a frequent comorbidity in @entity64 @entity1 . SDB is one of the independent risk factors for @entity385 . Conversely, @entity64 may contribute to SDB onset or aggravate premorbid SDB. Multiple mechanisms underlying SDB might be responsible for the development of @entity64 . The aim of this study was to compare polysomnographic, clinical, and laboratory characteristics of wake-up (WUS) and non-wake-up acute @entity385 (NWUS). METHODS: We prospectively enrolled 88 @entity1 with acute @entity385 . Clinical characteristics of the population were recorded on admission, and blood samples were obtained in the fasting condition following morning. SDB was assessed using standard overnight polysomnography in the acute phase of the @entity64 . RESULTS: WUS were present in 16 @entity1 (18.2%), and NWUS in 72 @entity1 (81.8%). In WUS compared to NWUS, we observed significantly higher values of @entity27 index (24.8 vs. 7.6, p = 0.007), desaturation index ([DI] 26.9 vs. 8.8, p = 0.005), arousal index (22.6 vs. 13.1, p = 0.035), diastolic blood pressure (91.6 mm Hg vs. 85.2 mm Hg, p = 0.039), @entity412 levels ([TG] 1.9 mmol/L vs. 1.2 mmol/L, p = 0.049), and significantly lower levels of D-dimer (0.4  g/L vs. 0.7  g/L, p = 0.035). DI (CI: 1.003-1.054, p = 0.031) and TG (CI: 1.002-1.877, p = 0.049) were the only independent variables significantly associated with WUS in binary logistic regression model. CONCLUSION: Although the design of our study does not prove the causal relationship between SDB and WUS, higher severity of SDB parameters in WUS supports this hypothesis.
