MicroRNA-144 suppresses @entity421 growth and @entity3 by targeting XXXX and @entity23759 .

@entity3478 @entity23759 @entity421 @entity9067 @entity3 @entity41669
@entity421 ( @entity421 ) is the most common @entity3478 . MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs that are strongly implicated in cancerous processes. However, our current understanding of the biological role of miRNAs in @entity421 remains incomplete. In the present study, @entity41669 was markedly downregulated in @entity421 cell lines and clinical specimens. Low-level expression of @entity41669 was significantly associated with distant @entity3 and poor prognosis. Functional studies demonstrated that ectopic expression of @entity41669 suppresses tumor cell proliferation and @entity3 in vitro as well as in vivo. Furthermore, we identified Rho-associated kinases 1 and 2 ( @entity9067 and @entity23759 ) as direct targets for @entity41669 binding, resulting in suppression of their expression. Exogenous expression of @entity9067 or @entity23759 in 143B- @entity41669 cells partially restored @entity41669 -inhibited cell proliferation and invasion. In clinical @entity421 specimens, @entity9067 and @entity23759 levels were elevated, relative to that in paired normal bone tissues, and inversely correlated with @entity41669 expression. Taken together, @entity41669 suppresses @entity421 progression by directly downregulating @entity9067 and @entity23759 expression, and may be a promising therapeutic target for @entity421 .
