[Expression of angiopoietin-1,2 and its relationship with angiogenesis in XXXX ].

@entity7 @entity5 @entity3658 @entity957 @entity877
OBJECTIVE: To investigate the expression of @entity3658 ,2 in @entity957 ( @entity957 ) and the relationship between @entity3658 ,2 expression and clinicopathologic parameters and microvessel density (MVD) marked by CD105, and also evaluate the significance of co-expression of @entity877 and @entity7 ( @entity7 ) in @entity5 angiogenesis. METHOD: The expression of @entity3658 ,2 and @entity7 in samples of @entity5 , para @entity5 and normal mucosa were detected by immunohistochemical method. RESULT: The expression of @entity3658 ,2 were identified in @entity957 , para @entity5 tissue and normal mucosa. The @entity7 expression was only existed in @entity957 . The expression of @entity3658 ,2 were significantly higher in @entity957 than in para @entity5 tissue (P < 0.05) and normal mucosa (P < 0.01). In the clinicopathologic parameters, only the expression of @entity877 was closely correlated with clinical stages and MVD (all P < 0.05). There was no significant correlation between the expression of @entity3658 ,2 and @entity5 differentiation degree (all P > 0.05). When the expression of @entity877 and @entity7 were both positive, the mean value of MVD was higher than others (P < 0.05). CONCLUSION: These results suggest that overexpression of @entity3658 ,2 may play a very important role in the development of @entity957 and are closely correlated with angiogenesis. @entity877 promote angiogenesis when interacting with @entity7 .
