Relationship of renal histological damage to glomerular XXXX in @entity1 with immunoglobulin A @entity8 .

@entity1 @entity8 @entity7598 @entity101 @entity16 @entity631
OBJECTIVE: Studies of experimental animals show glomerular @entity101 to be important in the progression of @entity8 . We evaluated this connection clinically by examining the relationship between glomerular hemodynamics and histological changes in @entity1 with immunoglobulin (Ig)A @entity8 . METHODS: The subjects were 23 @entity1 with @entity8 . All @entity1 underwent renal biopsies. Glomerular hemodynamics, in terms of glomerular capillary hydraulic pressure ( @entity7598 ) and the whole-kidney ultrafiltration coefficient, were calculated from the renal clearance, plasma total protein concentration, and pressure-natriuresis relationship. The severity of @entity631 , @entity16 and mesangial matrix expansion was evaluated semiquantitatively. RESULTS: @entity7598 ranged from 33-69 mm Hg, and the mean arterial pressure (MAP) from 79-112 mm Hg. Their correlation was not significant (r= 0.29, P= 0.18). @entity7598 was significantly correlated with the @entity631 score, and also with the score for @entity16 (r= 0.65, P < 0.001 and rs = 0.59, P = 0.007, respectively), but not with the score for mesangial matrix expansion (r= 0.08, P= 0.72). MAP was significantly correlated only with the score for @entity16 (rs = 0.63, P = 0.004). In multiple linear regression analysis of the histological changes and hemodynamics, the @entity631 score and the score for @entity16 were correlated with @entity7598 , but not with MAP. CONCLUSION: These clinical results support the speculation that glomerular @entity101 is involved in the @entity631 and @entity16 that occurs in @entity8 .
