RANK overexpression as a novel XXXX marker: validated immunohistochemical analysis of two different ethnicities.

@entity1 @entity1721 @entity418 @entity3 @entity3146
This study aimed to evaluate the receptor activator of nuclear factor-kB (RANK) expression statuses of @entity1721 ( @entity1721 ) @entity1 , @entity3146 ( @entity3146 ), @entity3146 ( @entity3146 ), and normal esophageal tissues (NETs) in Chinese Han and Kazakh ethnic, as well as the correlation of RANK expression with clinicopathological characteristics. RANK immunohistochemical analysis was conducted to investigate the expression of RANK in 113 @entity1721 , 36 @entity3146 , 63 @entity3146 , and 98 NETs from Han ethnic @entity1 and in 196 @entity1721 and 76 NETs from Kazakh ethnic @entity1 . The associations of RANK expression with ethnic and clinicopathological characteristics were examined using   (2)-test. Upregulated RANK expression was detected in both Han and Kazakh ethnic @entity1721 tissues, compared with NETs (P = 1.11*10(-5), 0.001, respectively). RANK expression was significantly increased during malignant transformation from normal epithelium into @entity3146 (P = 2.84*10(-7)) and @entity3146 (P = 7.83*10(-6)) tissues in Han ethnic @entity1 . The increased expression of RANK also correlated with lymph node @entity3 in Kazakh ethnic @entity1721 @entity1 (P = 0.019). By contrast, no significant correlation existed between RANK expression and clinicopathological characteristics of Han ethnic @entity1721 @entity1 . Furthermore, Kaplan-Meier survival analysis showed that @entity1721 @entity1 with higher expression of RANK protein had significantly worse prognosis than @entity1721 @entity1 with low or no expression (P = 0.001). In conclusion, this study is the first to identify RANK overexpression as a novel @entity418 marker in both Kazakh and Han ethnic @entity1721 @entity1 . The results support the association of RANK with @entity1721 across ethnicities. In summary, RANK could be a therapeutic target in @entity1721 @entity1 .
