Diagnostic usefulness of water-to-fat ratio and XXXX concentration in malignant and benign breast lesions and normal breast parenchyma: an in vivo (1) H MRS study.

@entity1 @entity1137 @entity3821 @entity0 @entity5 @entity189 @entity513 @entity1877
PURPOSE: To compare total @entity1877 concentrations ([Cho]) and water-to-fat (W/F) ratios of subtypes of @entity5 , benign lesions, and normal breast parenchyma and determine their usefulness in @entity0 . Reference standard was histology. MATERIALS AND METHODS: In this HIPPA compliant study, proton MRS was performed on 93 @entity1 with suspicious lesions (>1 cm) who underwent MRI-guided interventional procedures, and on 27 prospectively accrued @entity1 enrolled for screening MRI. (W/F) and [Cho] values were calculated using MRS data. RESULTS: Among 88 MRS-evaluable histologically-confirmed lesions, 40 @entity513 ( @entity513 ); 10 @entity1137 ( @entity1137 ); 4 @entity3821 ( @entity3821 ); 3 invasive @entity189 (IMC); 31 benign. No significant difference observed in (W/F) between benign lesions and normal breast tissue. The area under curve (AUC) of receiver operating characteristic (ROC) curves for discriminating the malignant group from the benign group were 0.97, 0.72, and 0.99 using [Cho], (W/F) and their combination as biomarkers, respectively. (W/F) performs significantly (P < 0.0001;AUC = 0.96) better than [Cho] (AUC = 0.52) in differentiating @entity1137 . CONCLUSION: Although [Cho] and (W/F) are good biomarkers for differentiating @entity5 , [Cho] is a better marker. Combining both can further improve diagnostic accuracy. @entity1137 have similar [Cho] levels but are discriminated using (W/F) values.
