[Complement activation following head and XXXX ].

@entity1 @entity46592 @entity131 @entity649 @entity26 @entity542 @entity5642 @entity8428 @entity130
The prognosis for a @entity1 with a severe @entity542 is dependent not only upon the location and the degree of this @entity130 , but also upon additional complications. For example, disseminated @entity5642 (DIC) can occur because of the thromboplastic activity of the damaged brain tissue that enters the circulation. The complement (C) system is activated by certain enzymes that cleave the clotting factors. Therefore, after @entity542 we searched for C activation because it could result in the @entity649 ( @entity649 ). @entity1 and methods. We had two groups of @entity1 : (1) 23 with large destruction and (2) 13 with little destruction of the brain tissue. Eighteen @entity1 in group 1 and 8 in group 2 had isolated @entity131 . Blood samples were taken--upon arrival at the hospital and then 1, 3, 7, 12, 24, and 48 h later; after that we took weekly blood samples up to the completion of their treatment in the intensive care unit. We measured the total hemolytic serum C activity (CH50), activation of alternative pathway hemolysis (APH50), cleavage products @entity46592 and @entity8428 , and total protein. Furthermore, we studied the coagulation parameters of the extrinsic (prothrombin time) and intrinsic (partial thromboplastin time) pathways and fibrinogen content. From the @entity1 records we extracted clinical parameters such as neurological status, intracranial pressure, pathological details on computer tomography hemoglobin and arterial-alveolar @entity26 difference. Results. Figure 1 shows the different reactions of the C system in both groups: while @entity1 of group 1 suffered from a decrease in total and alternative hemolytic activity, the other group increases in both parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
