Hemostasis in XXXX : low factor XIII levels in active disease.

@entity1 @entity2002 @entity1148 @entity548 @entity294 @entity30 @entity344 @entity19434 @entity360
Massive @entity360 sometimes occurs in @entity30 . To examine the possible role of acquired disorders of hemostasis contributing to such events, several laboratory indicators of hemostasis (APT time, Normotest, platelet count, @entity548 time, @entity2002 , factor VIII activity, vWF:Ag, factor X, factor XIII, antithrombin III, fibrinopeptide A, and B beta(15-42] were studied in 10 @entity1 with active @entity30 ( @entity30 activity index (CDAI) greater than 150) and 10 @entity1 with quiescent disease (CDAI less than 150). Marked @entity1148 was seen in three @entity1 with active disease. Factor VIII activity and @entity2002 levels were significantly elevated in @entity1 with @entity30 (p less than 0.001), and the factor VIII activity levels were significantly higher (p less than 0.05) in the @entity1 with active disease than in those with quiescent disease. Factor XIII levels were significantly lower (p less than 0.02) in @entity1 with active disease. Three of the @entity1 with active disease had factor XIII levels below the lower reference limit. The two @entity1 with the lowest levels had @entity548 @entity294 and spontaneous @entity548 from the rectal mucosa. Fibrinopeptide A and B beta(15-42) levels were significantly elevated in both groups. The other coagulation analyses were essentially normal in both @entity1 groups. The results suggest that @entity19434 acquired through @entity344 may contribute to @entity360 in some @entity1 with active @entity30 .
