[ XXXX with @entity1581 . 12 cases].

@entity1 @entity1581 @entity16 @entity305 @entity5805 @entity1897 @entity10838
12 cases of @entity305 with @entity1581 are reported. An analysis of the clinical, electrophysiological, histological and immunological features of these cases and of those reported in the literature allows to distinguish 2 groups. In the first group (8./12 cases), the @entity16 showed clinical and electrophysiological features of a mainly demyelinating mechanism involving large fibers. Electromicroscopy disclosed a widening of the spaces between the lamellae of the myelin in half of these cases. A monoclonal deposit of IgM was demonstrated by direct immunofluorescence, on the remaining myelinated fibers in most cases. In this first group, the M-component always reacted with the myelin sheaths of a monkey's peripheral nerve. The results of indirect immunofluorescence were closely correlated with those of immunoblotting, which revealed an anti-M.A.G. ( @entity10838 ) activity. The second group is more heterogeneous: there was an @entity1897 (1 case), an asymmetrical and painful @entity16 with an endoneural deposit of IgM (1 case). In 2 other cases which in no other ways differed from those of the first group, the M-component seemed devoid of antimyelinic activity. Nevertheless, the presence of IgM on the myelin sheaths of these 2 cases suggested a relationship between the @entity16 and the gammapathy. In both groups, results from the association of apheresis and @entity5805 were difficult to assess and vary greatly. Therapy appeared beneficent in half of the cases, but only one @entity1 was markedly improved.
