Severe @entity458 produced by morbid XXXX . Report of a case.

@entity1 @entity172 @entity251 @entity28 @entity73 @entity458 @entity53 @entity2124 @entity1815 @entity443
A 45-year-old @entity1 , was admitted for investigation of severe @entity458 . During 20 years of marriage, he had had no normal sexual intercourse and the couple was childless. Physical examination disclosed a severely @entity28 @entity1 (weight 300 kg, height 1.75 m), with a relatively small and invaginated penis and small (5 ml) soft testes. Laboratory examinations disclosed the following: low serum @entity251 (1 ng/ml), with a reduced response to HCG (3.8 ng/ml). @entity443 was at the lower limit of normal (0.38 microgram/dl), serum free @entity251 was low (0.98% of total @entity251 ) as well as non- @entity443 bound @entity251 (22% of total @entity251 ). Daily total urinary @entity172 excretion was increased (107 micrograms), the plasma @entity1815 (78 pg/ml) and @entity53 (74 pg/ml) were elevated. The gonadotropins were normal and responded adequately to LRH. Plasma @entity2124 was decreased, prolactin, T4 and adrenal steroids were normal and responded normally to stimuli and inhibitors. Chromosomal constitution was 46XY. Thus, in this @entity1 the marked @entity28 produced a significant increase in @entity172 which subsequently induced a severe decrease in @entity251 and its free counterpart in excessive @entity73 .
