Perioperative XXXX as an Adjunct for Postoperative Pain: A Meta-analysis of Randomized Controlled Trials.

@entity1 @entity3391 @entity4784 @entity14031 @entity601 @entity158 @entity1286
BACKGROUND: @entity3391 receptor antagonists have been shown to reduce perioperative @entity158 and opioid use. The authors performed a meta-analysis to determine whether the use of perioperative @entity14031 lowers @entity4784 or @entity158 scores. METHODS: PubMed, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Pubget, and EMBASE were searched. Studies were included if they were randomized, double-blinded, placebo-controlled trials written in English, and performed on @entity1 12 yr or older. For comparison of opioid use, included studies tracked total consumption of IV or intramuscular opioids over 24 to 48 h. @entity158 score comparisons were performed at 1, 4 to 6, and 24   h postoperatively. Difference in means ( @entity601 ) was used for effect size. RESULTS: Forty studies were identified and 21 were eligible for one or more comparisons. In 848 @entity1 from 14 trials, @entity4784 favored @entity14031 ( @entity601 , -10.51 mg IV @entity1286 equivalents; 95% CI, -16.48 to -4.53 mg; P = 0.0006). In 884 @entity1 from 13 trials, @entity158 at 1 h favored @entity14031 ( @entity601 , -1.60; 95% CI, -1.89 to -1.31; P < 0.00001). In 950 @entity1 from 13 trials, @entity158 at 4 to 6 h favored @entity14031 ( @entity601 , -0.89; 95% CI, -1.11 to -0.66; P < 0.00001). In 797 @entity1 from 12 trials, @entity158 at 24 h favored @entity14031 ( @entity601 , -0.92; 95% CI, -1.24 to -0.60; P < 0.00001). CONCLUSION: This meta-analysis suggests that @entity14031 use perioperatively reduces the postoperative @entity4784 at 24 to 48 h and @entity158 scores at 1, 4 to 6, and 24 h.
