Relationship between @entity1534 babA2 status with gastric epithelial cell turnover and XXXX .

@entity1 @entity1819 @entity194 @entity3621 @entity1534 @entity356 @entity6683
BACKGROUND: @entity1534 blood group antigen binding adhesin (BabA) mediates bacterial adherence to @entity1 blood group antigens on gastric epithelium. Although strains harbouring babA2 were recently found to be associated with peptic ulcer and @entity356 , the role of babA2 in cellular turnover, severity of @entity3621 , and premalignant changes is poorly understood. AIM: We correlated @entity1534 babA2, vacuolating toxin (vacA), and cytotoxin associated gene A (cagA) genotypes with the severity of @entity356 and epithelial cell turnover in a group of Chinese @entity1 from an area with a high incidence of @entity356 . @entity1 AND METHODS: @entity1534 isolates were obtained from 104 Chinese @entity1 who participated in a @entity356 prevention programme. Genotype variants of babA2, vacA, and cagA were determined by polymerase chain reaction. Antrum and corpus histopathology was examined according to the updated Sydney classification. Apoptosis was scored by terminal @entity6683 deoxynucleotidyl nick end labeling (TUNEL) and proliferation by Ki-67 immunostaining. RESULTS: Of the 104 @entity1 , 102 (98.1%) harboured cagA(+) strains and all had vacA s1 genotype. The babA2(+) strains were found in 83 (79.8%) @entity1 and were associated with higher lymphocytic infiltration (p=0.028), presence of @entity194 (odds ratio (OR) 7.5, 95% confidence interval (CI) 2.3-24.3), and intestinal metaplasia (OR 7.4, 95% CI 2.2-25.3) in the antrum. Increased epithelial proliferation was also noted in individuals infected with babA2(+) strains (p=0.025). Strains harbouring cagA(+)/vacA s1 genotypes lacked this association in the absence of babA2. CONCLUSIONS: The presence of babA2(+) @entity1534 strains alone or in combination with cagA(+) and vacA s1 was associated with the presence of preneoplastic @entity1819 .
