Pulse pressure/ XXXX index and left ventricular geometry and function: the LIFE Study.

@entity1 @entity64 @entity101 @entity6 @entity301 @entity1184 @entity9886 @entity633 @entity1011 @entity413 @entity165 @entity2693
OBJECTIVE: To evaluate the relationship between arterial @entity2693 estimated by the pulse pressure/ @entity64 index ratio (PP/SVi) and prognostically relevant abnormalities of left ventricular geometry and function. METHODS: Baseline data from the echocardiographic substudy of the @entity9886 Intervention For Endpoint (LIFE) Reduction in @entity101 Study were used. @entity1 involved in the present study had stage II-III @entity101 and electrocardiographic left ventricular @entity1184 ; those with a history of @entity301 or segmental wall motion abnormalities were excluded. Plasma @entity413 , total and high-density lipoprotein (HDL) @entity165 and @entity1011 concentrations and urinary albumin/ @entity1011 were assessed by standard methods. RESULTS: The study sample (n = 667) was subdivided into tertiles of PP/SVi. With greater PP/SVi, age, proportion of @entity1 and prevalence of type 2 @entity6 , systolic and mean blood pressures were greater, whereas body mass index, body height and diastolic blood pressure were lower. Total and HDL @entity165 , @entity1011 and @entity633 did not differ among the three groups. After adjustment for age, sex and body size, greater PP/SVi was related to concentric left ventricular geometry, but showed a weak negative relationship to left ventricular mass and aortic root diameter; the prevalence of aortic fibrocalcification and left atrial diameter did not differ among tertiles of PP/SVi. PP/SVi was related to greater left ventricular end-systolic stress; stress-corrected left ventricular chamber function was greater with greater PP/SVi, whereas myocardial contractility did not differ significantly among the three groups. Greater PP/SVi was related to greater mitral E-wave/A-wave ratio and shorter isovolumic relaxation time independently of age, sex, left ventricular geometry, systolic function and other confounders. CONCLUSION: Increased estimated arterial @entity2693 is associated with concentric left ventricular geometry and with diastolic left ventricular abnormalities suggestive of increased diastolic left ventricular @entity2693 .
