Effects of radiotherapy and surgery in early XXXX . An overview of the randomized trials. Early Breast Cancer Trialists' Collaborative Group.

@entity1 @entity204 @entity0
BACKGROUND: Randomized trials of radiotherapy and surgery for early @entity0 may have been too small to detect differences in long-term survival and recurrence reliably. We therefore performed a systematic overview (meta-analysis) of the results of such trials. METHODS: Information was sought on each subject from investigators who conducted trials that began before 1985 and that compared local therapies for early @entity0 . Data on mortality were available from 36 trials comparing radiotherapy plus surgery with the same type of surgery alone, 10 comparing more extensive surgery with less extensive surgery, and 18 comparing more extensive surgery with less extensive surgery plus radiotherapy. Information on mortality was available for 28,405 @entity1 (97.4 percent of the 29,175 @entity1 in the trials). RESULTS: The addition of radiotherapy to surgery resulted in a rate of local recurrence that was three times lower than the rate with surgery alone, but there was no significant difference in 10-year survival; among a total of 17,273 @entity1 enrolled in such trials, mortality was 40.3 percent with radiotherapy and 41.4 percent without radiotherapy (P = 0.3). Radiotherapy was associated with a reduced risk of @entity204 due to @entity0 (odds ratio, 0.94; 95 percent confidence interval, 0.88 to 1.00; P = 0.03), which indicates that, after 10 years, there would be about 0 to 5 fewer @entity204 due to @entity0 per 100 @entity1 . However, there was an increased risk of @entity204 from other causes (odds ratio, 1.24; 95 percent confidence interval, 1.09 to 1.42; P = 0.002). This, together with the age-specific @entity204 rates, implies, after 10 years, a few extra @entity204 not due to @entity0 per 100 older @entity1 or per 1000 younger @entity1 . During the first decade or two after diagnosis, the excess in the rate of such @entity204 that was associated with radiotherapy was much greater @entity1 who were over 60 years of age at randomization (15.3 percent vs. 11.1 percent [339 vs. 249 @entity204 ]) than among those under 50 (2.5 percent vs. 2.0 percent [62 vs. 49 @entity204 ]). Breast-conserving surgery involved some risk of recurrence in the remaining tissue, but no significant differences in overall survival at 10 years were found in the studies of mastectomy versus breast-conserving surgery plus radiotherapy (4891 @entity1 ), more extensive surgery versus less extensive surgery (4818 @entity1 ), or axillary clearance versus radiotherapy as adjuncts to mastectomy (4370 @entity1 ). CONCLUSIONS: Some of the local therapies for @entity0 had substantially different effects on the rates of local recurrence--such as the reduced recurrence with the addition of radiotherapy to surgery--but there were no definite differences in overall survival at 10 years.
