Antibiotic-induced immediate XXXX is a risk factor for positive @entity566 skin tests for neuromuscular blocking agents.

@entity1 @entity5159 @entity566 @entity56 @entity2898 @entity6305 @entity2900
BACKGROUND: Skin tests for neuromuscular blocking agents (NMBAs) are not currently recommended for the general population undergoing general anaesthesia. In a previous study we have reported a high incidence of positive @entity566 tests for NMBAs in @entity1 with a positive history of non-anaesthetic drug @entity566 , a larger prospective study being needed to confirm those preliminary results. The objective of this study was to compare the skin tests results for @entity1 with a positive history of antibiotic-induced immediate @entity56 reactions to those of controls without @entity56 . METHODS: Ninety eight @entity1 with previous antibiotic @entity56 and 72 controls were prospectively included. Skin tests were performed for @entity5159 , @entity6305 , @entity2898 , and @entity2900 . RESULTS: We found 65 positive skin tests from the 392 tests performed in @entity1 with a positive history of antibiotic @entity56 (1 6.58%) and 23 positive skin tests from the 288 performed in controls (7.98%), the two incidences showing significant statistical difference (p  =  0.0011). The relative risk for having a positive skin test for NMBAs for @entity1 versus controls was 1.77 (1.15-2.76). For @entity5159 , skin tests were more often positive in @entity1 with a positive history of antibiotic @entity56 versus controls (p  =  0.02). For @entity6305 , @entity2898 and @entity2900 the statistical difference was not attained (p-values 0.08 for @entity6305 , 0.23 for @entity2898 , and 0.26 for @entity2900 ). CONCLUSIONS: @entity1 with a positive history of antibiotic @entity56 seem to have a higher incidence of positive skin tests for NMBAs. They might represent a group at higher risk for developing intraoperative anaphylaxis compared to the general population.
