Influence of vessel involvement and early streptokinase therapy on regional and global left ventricular function in acute XXXX .

@entity1 @entity66 @entity1188 @entity74 @entity158 @entity583 @entity850
150 consecutive @entity1 with acute @entity583 received 750,000 units of intravenous streptokinase within four hours of @entity158 onset. Angiography was performed on day 6, from which ejection fraction (EF), @entity1188 -related ejection fraction (IREF), and non- @entity1188 related ejection fraction (NREF) were calculated. 50% @entity850 was considered to be significant. The streptokinase @entity1 with patent @entity1188 who had no evidence of previous @entity583 were compared with 82 conventionally treated (without streptokinase) @entity1 who had no evidence of previous @entity583 . Sub-group analysis based on vessel involvement, usage and timing of streptokinase was done. Streptokinase was associated with better left ventricular function in all sub-groups if given less than 2 hours after @entity158 onset. In @entity583 , streptokinase @entity1 with @entity66 had normal EF (67 +/- 8), compared to significantly depressed @entity74 (56 +/- 12, p less than 0.05). This difference is accounted for more by the NREF than the IREF. In anterior @entity1188 , @entity1 with @entity66 did only slightly better than multi-vessel disease. In multi- and single-vessel anterior @entity1188 , preservation of function by streptokinase appears to be due to the compensatory ability of the non-infarcted region as well as the residual function of the @entity1188 -related region. region.
