@entity1358 with @entity3 to the @entity1085 : four cases from the National XXXX Institute (NCI) and review of the literature.

@entity1 @entity1085 @entity5 @entity1358 @entity3
OBJECTIVE: We evaluate presentation and outcome of @entity1 with metastatic @entity1085 from our institution and published literature. METHODS: @entity1 with a history of @entity1085 @entity3 from @entity1358 were selected from our institution's prospective database. A systematic PubMed search was performed to identify articles describing @entity1 with metastatic @entity1085 . The final cohort included 33 @entity1 : 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using log-rank Kaplan-Meier analysis. RESULTS: Median @entity1 age was 63 years and the majority of @entity1 were male. Most @entity1 were asymptomatic and diagnosed with @entity1085 @entity3 on imaging performed for surveillance or staging. The median time to @entity1085 @entity3 following nephrectomy was 4 years. @entity3 to the @entity1085 occurred both synchronously (33%) and metachronously (67%). Of the @entity1 with available histology, all had clear cell @entity1358 (n = 28). Of all @entity1 , 13 (39%) had @entity3 only to the @entity1085 , while 20 (61%) had additional sites of @entity3 . The most common sites of additional @entity3 were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All @entity1 underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of @entity1 had no evidence of disease, 14% were alive with @entity3 , 23% had died from metastatic @entity1358 , and 9% died from causes unrelated to their @entity5 . CONCLUSION: Gallbladder @entity3 from @entity1358 is a rare event that may occur synchronously or metachronously with most @entity1 being asymptomatic. @entity1358 appears to be the primary pathology associated with @entity1085 @entity3 . High rates of bilateral @entity1358 and pancreatic @entity3 suggest novel associations in @entity1 with @entity1358 and @entity1085 @entity3 .
