Delayed laparoscopic cholecystectomy increases the total hospital stay compared to an early laparoscopic cholecystectomy after acute XXXX : an updated meta-analysis of randomized controlled trials.

@entity1 @entity2679 @entity910 @entity11274
BACKGROUND: The objective of this study was to review the available prospective, randomized, controlled trials to determine whether an early ( @entity11274 ) or a delayed (DLC) approach to a laparoscopic cholecystectomy is associated with an increase in length of hospitalization after acute @entity2679 . METHODS: Medline, the Cochrane Trials Register and EMBASE were searched for prospective, randomized, controlled trials (RCTs) comparing @entity11274 versus DLC, published up to May 2014. A meta-analysis was performed using Review Manager 5.0. RESULTS: Nine RCTs were included in a total of 617 who underwent @entity11274 and 603 @entity1 who underwent DLC after acute @entity2679 . The mean hospital stay was 5.4  days in the @entity11274 group and 9.1  days in the DLC group. The meta-analysis showed a mean hospital stay significantly lower in the @entity11274 group [ @entity910 ( @entity910 )  =  3.24, 95% confidence interval (CI)  =  1.95-4.54, P  <  0.001]. The major biliary duct injury rate in the @entity11274 group was 0.8% (2/247) and 0.9% (2/223) in the DLC group. The meta-analysis showed no significant difference between the @entity11274 and DLC groups [relative risk (RR)  =0.96, 95%CI  =  0.25-3.73, P  =  0.950]. CONCLUSION: DLC is associated with a longer total hospital stay but equivalent morbidity as compared to @entity11274 for @entity1 presenting with acute @entity2679 . @entity11274 would appear to be the treatment of choice for @entity1 presenting with @entity11274 .
