High lipid levels and XXXX in @entity1 in G  teborg--outcome and secular trends: a prospective 19 year follow-up in the BEDA*study.

@entity1 @entity301 @entity1674 @entity412 @entity583 @entity65 @entity165
AIMS: To provide contemporary data on the effect of high @entity165 and high @entity1674 on the risk of @entity301 ( @entity301 ) and mortality in Swedish @entity1 and to describe secular trends with respect to serum lipids, body mass index (BMI) and smoking in the source population. METHODS: We followed 1372 @entity1 aged 39-64 years and without prior @entity65 from 1980 to 1999 through record-linkage with the Swedish hospital discharge and cause-specific death registers. Risk factor measurements were done at baseline. Every fifth year between 1980 and 1995 coronary risk factors were assessed in independent samples of the source population. RESULTS: In multivariate analyses, a 1 mmol increase in @entity165 was associated with a 51% increased risk of @entity583 ( @entity583 ) and/or revascularisation ( @entity583 ; p<0.0001) and a 30% increased risk of being hospitalised for @entity301 (p<0.0004). @entity1 with @entity165 , 7-7.9 mmol/l, had a threefold risk of @entity583 (HR 3.44 (1.63-7.23)) and hazard ratios in the highest @entity165 category, > or =8 mmol/l, was 4.49 (1.92-10.50) as compared to @entity1 with @entity165 below 6 mmol/l. A 1 mmol increase in @entity1674 was associated with a 49% increased risk of @entity583 (p=0.002) and a 45% increased risk of being hospitalised for @entity301 (p=0.001) after adjustment for major coronary risk factors. A moderate increase in @entity1674 , 1.0-1.5 mmol/l, conferred no significant increase in risk of coronary events as compared to below 1.0 mmol/l. @entity1 with high @entity1674 , 1.5-1.9 mmol/l, had a doubled risk of @entity583 (HR 2.55 (1.20-5.42)) and hazard ratios in the highest @entity412 category, > or =2.0 mmol/l, was 3.35 (1.48-7.60). Both high @entity165 and high @entity1674 predicted mortality but the magnitude was smaller than for coronary events. During the study period the proportion of @entity1 with low @entity165 profile, below 6.0 mmol/l, increased on average from 49 to 68% and the proportion of @entity1 with low @entity412 levels, below 1.0 mmol/l, decreased from 59 to 36% in the source population. A modest increase in BMI was noted. CONCLUSIONS: Both high fasting @entity165 and high fasting @entity1674 strongly predicted coronary events in middle-aged Swedish @entity1 . The favourable decline in @entity165 levels and smoking rates during the study period was offset by a marked increase in @entity412 levels. The findings suggest that interventional strategies directed to correct abnormalities in the @entity412 metabolism may be specifically warranted in @entity1 .
