The XXXX in @entity3458 : incidence and risk factors. The Cooperative Study of @entity3458 .

@entity1 @entity7723 @entity417 @entity13654 @entity55 @entity3458 @entity5837 @entity1030 @entity204 @entity2395
The @entity5837 ( @entity5837 ), a @entity55 -like illness in sickle cell @entity1 , is one of the most frequent causes of their morbidity and hospitalizations. Repeated @entity5837 events may predict the development of @entity1030 . @entity5837 is reported as a frequent cause of @entity204 in these @entity1 . We examine here the incidence and risk factors of @entity5837 in 3,751 @entity1 with @entity3458 who were observed prospectively for at least 2 years (19,867 @entity1 -years [pt-yrs]) as part of a multicenter national study group. The @entity5837 , defined by a new pulmonary infiltrate on x-ray, occurred at least once in 1,085 @entity1 (2,100 events). @entity5837 incidence was higher in @entity1 with homozygous @entity3458 (SS; 12.8/100 pt-yrs) and in @entity1 with sickle cell-beta(0) -thalassemic (9.4/100 pt-yrs), and lower in @entity1 with hemoglobin (Hb) @entity13654 (5.2/100 pt-yrs) and @entity1 with sickle cell-beta(+) @entity2395 (3.9/100 pt-yrs). @entity7723 did not affect the rate of @entity5837 incidence in SS @entity1 . Within each Hb type the incidence was strongly but inversely related to age, being highest in @entity1 2 to 4 years of age (25.3/100 pt-yrs in SS) and decreasing gradually to its lowest value in adults (8.8/100 pt-yrs in SS). In SS @entity1 (< 10 years of age), we documented an age-related within- @entity1 reduction in @entity5837 attack rates. Adults with a higher @entity5837 rate had a higher rate of mortality (from all causes) than those with low @entity5837 rates. This increased rate of mortality might also have contributed to the decline in @entity5837 rate with age. In multivariate analysis, other factors affecting incidence in SS @entity1 were degree of @entity417 (lower @entity5837 rates in @entity1 with lower steady-state Hb levels) and fetal Hb (lower rates in @entity1 with high fetal Hb). There was also a positive association between @entity5837 rate and steady-state leukocyte count. The relationship of @entity5837 rate to higher steady-state Hb levels in SS @entity1 is unexplained but might be caused by increased blood viscosity.
