Effects of @entity349 on XXXX polymorphonuclear leukocyte function in vitro.

@entity1 @entity137 @entity274 @entity3143 @entity349 @entity26 @entity3460 @entity880
A variety of heavy metals are recognized as environmental pollutants, and although a significant body of literature exists on the acute @entity137 of these metals in various tissues, little is known about the effects of metals such as @entity349 on host defense. Therefore, the effect of @entity3143 ( @entity3143 ) on @entity1 polymorphonuclear leukocytes (PMN) function in vitro was evaluated. The acute @entity137 of @entity3143 for @entity1 PMN was calculated initially using vital dye exclusion (trypan blue), and @entity880 dehydrogenase (LDH) release. Concentrations of @entity3143 less than or equal to 10(-6) M did not induce significant LDH release, or uptake of @entity3460 . Additionally, @entity3143 at less than or equal to 10(-7) M produced no ultrastructural alterations in the PMN. The effects of @entity3143 on @entity1 PMN functions involved in host defense were evaluated next. @entity3143 consistently suppressed @entity1 PMN adherence, polarization, chemotaxis, and erythrophagocytosis at concentrations between 10(-6) and 10(-17) M. Because of the established role of @entity26 metabolites in host defense, the effects of @entity3143 on @entity1 PMN chemiluminescence and @entity274 production were evaluated next. These studies demonstrated that low concentrations of @entity3143 (ie, 10(-9)-10(-15) M) significantly enhanced chemiluminescence, as well as stimulated @entity274 production by the PMN. These studies clearly demonstrate the ability of extremely low levels of @entity3143 not only to suppress various PMN functions involved in host defense, but also to stimulate @entity26 metabolism. In vivo, these @entity3143 effects would not only compromise host defense but also promote tissue injury via the local production of @entity26 metabolites.
