[The effect of @entity519 on cholinesterase activity in XXXX sensorimotor cortex].

@entity16855 @entity26 @entity2140 @entity4833 @entity519 @entity179 @entity3612 @entity195 @entity35
This study reports the dynamics of changes in postnatal ontogenesis of the activity of soluble and membrane-bound forms of @entity4833 ( @entity4833 ) and @entity16855 ( @entity16855 ) in sensorimotor cortex of @entity35 as well as the pattern of their changes after prenatal @entity519 (E14, 7% @entity3612 , 3 h) or acute @entity519 in adult animals (4 months, 7% @entity3612 , 3 h). In normally developing @entity35 the activity of the membrane-bound @entity4833 form in the sensorimotor cortex gradually increased up to the end of the first month after birth and remained at this high level during all further postnatal ontogenesis, while the activity of the soluble form of @entity4833 reached its maximum on the 10th day after birth and decreased significantly by the end of the first month. In animals exposed to prenatal @entity519 the activity both of the soluble and membrane bound forms of @entity4833 during the first two weeks after birth was 20-25% lower, as compared to controls but increased by the end of the first month and even exceeded the control values remaining increased up to old age (1.5 years). The activity of both @entity16855 forms in @entity35 sensorimotor cortex at all stages of postnatal ontogenesis was significantly lower than of @entity4833 , although the dynamics of their changes was similar to that of @entity4833 . Prenatal @entity519 led to a decrease in the activity of the membrane-bound form of @entity16855 , as compared to controls, practically at all developmental stages studied, but was higher at the end of the first month after birth. At the same time, the activity of the soluble form of @entity16855 was decreased only on the 20th day of development, as compared to the control, but increased from the end of the first month of life onwards. Acute @entity519 in adult @entity35 also led to a decrease in the activity of both forms of @entity4833 and @entity16855 in the sensorimotor cortex but the dynamics of these changes was different for each enzyme. Thus, insufficient @entity26 supply to the nervous tissue at different stages of ontogenesis has a significant effect on the activity and ratio of various forms of cholinesterases exhibiting either @entity2140 or signaling properties. This may lead to changes in brain development and formation of behavioural reactions, including learning and memory, and also increase the risk of development of the sporadic form of @entity195 ( @entity195 )--one of the most common @entity179 of advanced age. This study expands our knowledge of the properties of brain cholinesterases under normal and pathological conditions and may be useful for developing new approaches towards prevention and treatment of @entity195 .
