Early redox unbalance is associated with @entity409 at weaning in overfed XXXX .

@entity3725 @entity28 @entity5733 @entity35 @entity1184 @entity24344 @entity409 @entity6229 @entity37724 @entity412 @entity209 @entity2661
BACKGROUND: Neonatal overfeeding induced by litter size reduction leads to further @entity28 and other @entity209 , such as liver oxidative stress and microesteatosis at adulthood. We hypothesized that overfeeding cause an early redox unbalance at weaning, which could program the animals to future @entity409 . Thus, we studied lipogenesis, adipogenesis, @entity5733 status and oxidative balance in weaned overfed pups. METHODS: To induce early overfeeding, litters were adjusted to 3 pups at the 3(rd) day of lactation (SL group). The control group remained with 10 pups per litter until weaning (NL group). The peripheral autonomic nerve function was determined in vivo at 21 days-old. Thereafter, pups were killed for further analysis. Significant differences had P  <  0.05. RESULTS: The SL pups presented higher visceral adipocyte area, higher content of lipogenic enzymes (ACC, @entity24344 ) with lower content of adipogenic factors ( @entity37724 , PPARy) in visceral adipose tissue (VAT). Although the autonomic nerve activity and adrenal @entity2661 production were not significantly altered, @entity5733 receptor (b3ADR) was lower in VAT. They presented higher @entity412 , PPARy, @entity3725 and @entity6229 contents in liver. In plasma and liver, the SL pups showed an oxidative unbalance, with higher lipid peroxidation and protein oxidation. The SL group presented higher serum ALT. CONCLUSION: The early increased lipogenesis at adipose tissue and liver in weaned overfed @entity35 , suggest that the higher oxidative stress and lower @entity5733 effect in VAT is associated with the early development of @entity409 and adipocyte @entity1184 . This article is protected by copyright. All rights reserved.
