Autologous stem cell transplantation using a modified TAM conditioning regimen for clinically aggressive XXXX .

@entity1 @entity137 @entity401 @entity33 @entity2592 @entity1442 @entity348 @entity2101 @entity1893 @entity221
PURPOSE: @entity2101 ( @entity2101 ) and autologous stem cell transplantation (ASCT) have been used for the treatment of clinically aggressive @entity1893 ( @entity1893 ). However, the superiority of specific conditioning regimens has not yet been established. The present study evaluated the efficacy and @entity137 of a conditioning regimen involving fractionated @entity348 ( @entity348 ), and the use of @entity2592 and melphalan (TAM) for clinically aggressive @entity1893 . MATERIALS AND METHODS: Between March 2002 and December 2004, 31 @entity1 with aggressive @entity1893 received fractionated @entity348 with a dose of 12 Gy over 3 days, and were administered 9 g/m(2) @entity2592 and 100 mg/m(2) melphalan followed by autologous peripheral blood stem Cell Transplantation at the Catholic Hematopoietic Stem cell transplantation Center Korea. @entity1 that responded to first line chemotherapy and achieved complete remission (CR), or were in a first sensitive relapse were defined as having @entity1442 , while the other @entity1 were defined as having more advanced disease. RESULTS: Objective responses were obtained in 24 of 31 @entity1 (77.4%), comprising complete remission in 19 @entity1 (61.3%) and partial remission in 5 (16.1%) @entity1 . The median follow-up time was 28 months (range 1 approximately 62 months). At 3 years, the overall survival and event-free survival (EFS) rates were 62.3% and 47.3%, respectively. @entity1 with @entity1442 and more advanced disease showed 3-year EFS rates of 73.3% and 22.5 %, respectively (p=0.006). Early (within the first 100 days) treatment-related mortality occurred in 3 (9.7%) @entity1 . Of the 31 total @entity1 , 15 (48.4%) developed grade 3 @entity33 , 22 (70.9%) developed @entity221 , and two (6.5%) developed @entity401 >grade 3. CONCLUSION: The modified TAM conditioning regimen and ASCT appear to be a feasible treatment regimen for clinically aggressive @entity1893 , particularly for @entity1 with @entity1442 .
