Exogenous thyrotropin improves renal function in euthyroid patients, while serum @entity1011 levels are increased in XXXX .

@entity1 @entity1375 @entity8789 @entity1955 @entity1011
BACKGROUND: There is evidence showing that the @entity1375 state results in increased serum @entity1011 levels. However, whether this is only due to the peripheral thyroid hormones or if thyroid-stimulating hormone (TSH) is also involved is not known. METHODS: Serum @entity1011 levels and estimated glomerular filtration rate (eGFR) were assessed in thyroidectomized @entity1 with varying thyroid hormones and TSH levels. Blood samples from Group 1 (21 @entity1 ) were obtained 1 month after complete thyroidectomy, while under a @entity1375 state (t1) and a sufficient time after @entity8789 initiation (euthyroid state, t2). Group 2 (20 euthyroid @entity1 ) were sampled after recombinant @entity1 thyrotropin injections (rhTSH, t1) and later after rhTSH extinction (t2). RESULTS: In Group 1, serum @entity1011 levels decreased after correction of @entity1375 (85.3    4.3 versus 78.0    3.9   mol/L; P = 0.04). In Group 2, serum @entity1011 levels increased after rhTSH withdrawal (70.6    5.7   mol/L versus 76.5    5.8   mol/L; P = 0.007). Between t1 and t2, eGFR varied accordingly [Group 1, 71.7    3.5 versus 81.2    4.5 mL/min/1.73 m   (P = 0.02); Group 2, 97.7    7.4 versus 87.5    5.9 (P = 0.007)]. The changes in TSH and eGFR following supplementation with @entity1955 were significantly correlated (r = -0.6, P = 0.0041). CONCLUSIONS: @entity1375 significantly increases serum @entity1011 and reversibly impairs eGFR, while treatment with rhTSH enhances renal function in euthyroid @entity1 , supporting the existence of an influence of TSH level on renal function. The mechanisms by which peripheral thyroid hormones and TSH influence GFR need to be identified in physiology-orientated studies.
