d-Dimer Levels are Significantly Increased in Blood Taken From Varicose Veins Compared With Antecubital Blood From the Same XXXX .

@entity1 @entity66 @entity2631 @entity1150 @entity715 @entity291
UNASSIGNED: d-Dimer is a prothrombotic biomarker and a very sensitive measure of endogenous fibrinolysis. It is used as a screening test for suspected @entity1150 . This study investigated whether d-dimer levels were increased in the varicose veins of @entity1 in comparison to their own arm samples. @entity1 , n = 24, 17 male, age 45 (25-91), C2-6, awaiting saphenous laser ablation were compared to matched controls, n = 24, 17 male, age 42 (24-89). Concurrent venous blood samples were taken from the arm and a lower @entity291 /ankle (varicose) vein. The median (interquartile range) d-dimer (ng/mL) level was significantly greater in the ankle than in the arm blood of the same @entity1 at 319 (164-631) versus 281 (167-562), P = .003, Wilcoxon. This did not occur in the controls at 269 (80-564) versus 262 (106-526), P = .361, Wilcoxon. The results indicate increased endogenous fibrinolysis in varicose veins compared with arm blood. This suggests there is more @entity715 activity or dissolution of formed subclinical fibrin @entity715 which may explain the association of varicose veins with @entity715 . This contrasts with earlier studies reporting a @entity2631 in fibrinolysis in @entity66 .
