Effect of dual-focus soft contact lens wear on @entity18061 in XXXX .

@entity1 @entity5394 @entity227 @entity2516 @entity735 @entity18061 @entity1714
PURPOSE: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing @entity18061 . DESIGN: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. @entity1 : Forty @entity1 , 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71    1.10 diopters (D). METHODS: Dual-Focus lenses had a central zone that corrected @entity2516 and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a @entity227 ( @entity227 ) lens with the same parameters but without treatment zones. @entity1 wore a DF lens in 1 randomly assigned eye and an @entity227 lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months ( @entity5394 ). MAIN OUTCOME MEASURES: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in @entity735 ( @entity735 ) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. RESULTS: In period 1, the mean change in SER with DF lenses (-0.44    0.33 D) was less than with @entity227 lenses (-0.69    0.38 D; P < 0.001); mean increase in @entity735 was also less with DF lenses (0.11    0.09 mm) than with @entity227 lenses (0.22    0.10 mm; P < 0.001). In 70% of the @entity1 , @entity18061 was reduced by 30% or more in the eye wearing the DF lens relative to that wearing the @entity227 lens. Similar reductions in @entity18061 and @entity735 were also observed with DF lens wear during @entity5394 . Visual acuity and contrast sensitivity with DF lenses were not significantly different than with @entity227 lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. CONCLUSIONS: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. @entity1714 progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow @entity18061 without compromising visual function. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
