Effects of Serum @entity414 on Estimated GFR in Cardiac Surgery XXXX : A Pilot Study.

@entity1 @entity810 @entity1011 @entity15901 @entity414
BACKGROUND: The aim of the study was to investigate the effects of serum @entity414 (SUA) on @entity810 ( @entity810 ) in @entity1 undergoing cardiac surgery. METHODS: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and @entity810 as assessed by @entity15901 ( @entity15901 ), serum @entity1011 (SCr) and kinetic estimated glomerular filtration rate (KeGFR). RESULTS: @entity1 undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present between SUA and @entity15901 measured at postoperative 1 h (r = 0.39, p = 0.008), 6 h (r = 0.31, p = 0.029) and 24 h (r = 0.31, p < 0.001), respectively. Significant correlations were also noted between SUA and SCr measured on postoperative day 1 (r = 0.41, p = 0.006), day 2 (r = 0.29, p = 0.042) and day 3 (r = 0.42, p = 0.009). Negative correlations were demonstrated between SUA and day 1 (r = -0.44, p = 0.007), day 2 (r = -0.43, p = 0.007), day 3 (r = -0.44, p = 0.006 and day 4 KeGFR (r = -0.35, p = 0.035). The inverse relationship of SUA and KeGFR was also demonstrated with a different method (Jelliffe) of measurement. CONCLUSIONS: A reduction in glomerular filtration rate (GFR) can lead to a rise in SUA. However, in this study, we are able to show that SUA at 1 h (maximal dilution time) effectively predicts subsequent changes in urinary @entity15901 , SCr, KeGFR, and the development of @entity810 . Thus, these findings suggest that @entity414 precedes and predicts acute changes in renal function and cannot be ascribed to a simple relationship in which a reduced GFR raises SUA.
