Antibiotic prophylaxis in surgery of the intervertebral disc. A comparison between XXXX and @entity2261 .

@entity2261 @entity801 @entity1 @entity1512
Antibiotics are often administrated prophylactically in spinal procedures to reduce the risk of infection of the disc space. It is still not known which antibiotics are able to penetrate the intervertebral disc effectively. In a prospective, randomised, double-blind clinical study, we examined the penetration of the intervertebral discs of two commonly used antibiotics, @entity2261 and @entity801 . The @entity1 , randomised into two groups, received either 1.5 g of @entity2261 or 5 mg/kg of @entity801 prophylactically two hours before their intervertebral discs were removed. A specimen of blood, from which serum antibiotic levels were determined, was obtained at the time of discectomy. Therapeutic levels of antibiotic were detectable in the intervertebral discs of the ten @entity1 who received @entity801 . Only two of the ten @entity1 (20%) who received @entity2261 had a quantifiable level of antibiotic in their discs although therapeutic serum levels of @entity2261 were found in all ten @entity1 . Our results show that @entity2261 does not diffuse into @entity1 intervertebral discs as readily as @entity801 . It is possible that the charge due to ionisable groups on the antibiotics can influence the penetration of the antibiotics. We therefore recommend the use of @entity801 in a single prophylactic dose for all spinal procedures in order to reduce the risk of @entity1512 .
