Parallel adrenal and XXXX in young @entity1 with essential @entity101 .

@entity1 @entity8 @entity1369 @entity101 @entity1372 @entity1483 @entity3194 @entity51 @entity972 @entity916
To determine whether the previously described abnormalities in @entity8 in essential @entity101 are associated, we examined the responses to the relevant systems in 18 @entity1 with essential @entity101 . Young @entity1 , under 30 years of age, were studied to minimize the likelihood that the phenomena were secondary to long-standing @entity101 . To achieve a wide span of @entity1372 balance, studies were performed during a high (200 mEq) @entity1372 intake, a restricted (10 mEg) @entity1372 intake and a restricted @entity1372 intake supplemented by a further short-term diuretic-induced @entity51 ( @entity1483 , 180 to 300 mg, to reduce body weight by 1 to 1.5 kg). The indexes measured included cardiac output ( @entity3194 indicator dilution), plasma volume (125 I albumin space), renal blood flow (radioxenon transit), plasma @entity916 activity and @entity1369 levels and @entity1369 secretory rate. All of these variables, with the exception of blood pressure and total peripheral resistance, were within the normal range during the two diets. However, the @entity1369 secretory response to diuretic-induced volume depletion on a low- @entity1372 diet was clearly blunted in nine subjects. These nine subjects (abnormal responders) had a virtually absent @entity1369 increment (23 +/- 34 micrograms per 24 hours) compared with the normal responders (502 %/- 70 micrograms per 24 hours). In addition, renal blood flow was significantly higher in these same nine subjects during both a high @entity1372 intake (434 +/- 19 versus 342 +/- 26 ml/100 g per minute) and a restricted @entity1372 intake /446 +/- 11 versus 285 +/- 39 ml/100 g per minute). Yet, there were no significant differences between these two groups in @entity1372 or @entity972 balance, blood pressure, plasma volume, cardiac index or plasma @entity916 activity during a high or low @entity1372 intake. Normally, control of both @entity1369 release by the adrenal and renal perfusion is dominated by angiotensin; an apparently blunted response of both systems suggests that there may be a generalized abnormality in the way angiotensin interacts with its target tissues in many young @entity1 with essential @entity101 .
