[The detrimental effect of XXXX as an intra-uterine instillation in mares].

@entity1496 @entity82 @entity548 @entity39 @entity4 @entity1373 @entity6922 @entity4648 @entity4288
Fifty ml of a 0.2% @entity1496 solution were instilled into the uteri of six mares selected for culling. Biopsy specimens were taken for microscopic examination before the commencement of the experiment and at various times over the course of a year after the single instillation. Severe @entity4 and @entity548 was present in the lamina propria of all the post-instillation biopsy specimens. The epithelium showed vacuolisation and @entity39 , as well as focal areas of epithelial loss. In some cases @entity1373 or @entity4648 was seen. Cell infiltration was characterized by the presence of neutrophils, eosinophils and mild lymphocyte infiltration around the blood vessels. @entity6922 was present around the blood vessels in some specimens. Blood vessel changes were characterized in the early stages by @entity4 of the tunica media of the medium-sized arteries and later by @entity4288 with the complete obliteration of the lumen of the particular vessels in some cases. The endometrial glands showed @entity1373 and mitotic figures were more often seen in these glands than normal. The most pronounced lesion in the later stage of the experiment was @entity82 of the lamina propria with the resultant collapse of the stratum compactum and contraction of the stratum spongiosum. The severe @entity82 of the endometrium is the most probable reason for infertility in mares treated with @entity1496 .
