Dietary conjugated XXXX decrease leptin in porcine adipose tissue.

@entity1707 @entity50342 @entity669 @entity4721 @entity13357 @entity1386
We investigated the effects of dietary conjugated @entity4721 ( @entity13357 ) on @entity1386 ( @entity1386 ) in heavy @entity1707 . Twelve @entity1707 were assigned to 1 of 2 groups supplemented with either 0 or 0.75% of a @entity13357 preparation (isomeric mixture) and were slaughtered at 159 +/- 2.3 kg live weight. Their subcutaneous @entity1386 was analyzed by both chemical and microanatomical methods. The @entity1386 of @entity13357 -fed @entity1707 tended to have a higher protein content (P = 0.064) and smaller adipocytes (P = 0.053) than that of control (CTR) @entity1707 . The number of proliferating preadipocytes tended to be greater (P = 0.076) in @entity1707 fed @entity13357 , whereas the number of apoptotic adipocytes was greater (P < 0.01) than in CTR @entity1707 . Immunohistochemistry revealed that leptin (Ob) expression was lower (P = 0.048) in adipocytes from treated @entity1707 and Western blot quantification of Ob revealed lower levels (P < 0.05) in @entity13357 -fed @entity1707 . The @entity50342 was not affected by dietary @entity13357 supplementation. @entity669 hydroxylase activity was higher (P < 0.001) in @entity1386 of @entity13357 fed- @entity1707 than in CTR. It is conceivable that the increased noradrenergic activity due to dietary @entity13357 decreases the Ob expression, although it does not diminish the lipid content of @entity1386 , at least in heavy @entity1707 . This article describes the interaction between @entity13357 and Ob in the @entity1386 of heavy @entity1707 and we hypothesize that there is an increased noradrenergic stimulation of lipolysis directly in the target tissue.
