Structural-functional correlations in serial biopsies from @entity1 with XXXX .

@entity1 @entity8 @entity82 @entity75 @entity16 @entity1011 @entity631
It has been proposed that interstitial @entity82 is causally related to a progressive decrease in glomerular filtration rate (GFR), in @entity1 with various @entity8 . We examined the relationship between morphological and functional parameters in 200 samples from 74 @entity1 with @entity631 . The @entity8 was semiquantitatively analyzed using the Glomerular Index (GI). Interstitial volume (IV) was determined by the point-counting method. Both GI and IV showed a significant negative correlation with Ccr and a positive correlation with serum @entity1011 . The serial change in IV from the first to the last biopsy (delta IV) showed a weak but significant negative correlation with those in Ccr, over the same period (delta Ccr). The serial change in GI (delta GI) did not correlate with delta Ccr. There was a significant positive correlation between GI and IV and between delta GI and delta IV. These data confirmed a cause-and-effect relationship between @entity16 and GFR and also showed that the @entity8 as well as the interstitial change play an important role in the deterioration of renal function. Thus, the @entity75 alone should not be emphasized as a determinant of renal function, as we noted a close correlation between the @entity8 . @entity16 is apparently secondary to the @entity8 in @entity1 with @entity631 .
