Pregnancy and early-stage XXXX .

@entity1 @entity146 @entity5 @entity1066 @entity320
BACKGROUND: Cutaneous @entity320 are @entity146 with an unpredictable biologic behavior. It has been suggested that @entity1 who present with @entity320 during pregnancy have a worse prognosis due to more aggressive behavior of the @entity320 . The objective of the current study was to evaluate the long-term effect of pregnancy on disease progression in @entity1 with Stage I-II @entity320 . METHODS: From 1965 to 2001, 46 pregnant @entity1 were treated for a Stage I-II @entity320 at the University Medical Center Groningen. These @entity1 were compared with an age-matched and gender-matched control group (nonpregnant) of 368 @entity1 with Stage I-II @entity320 . The @entity1 were staged according to the 2002 American Joint Committee on Cancer TNM classification system for @entity320 . The 10-year disease-free survival (DFS) and 10-year overall survival (OS) rates were calculated using logistic regression analysis. RESULTS: The median age of @entity1 in the pregnant group was 30 years (range, 18-46 years), and the median age of @entity1 in the nonpregnant group was 36 years (range, 17-45 years). The median follow-up was 109 months (range, 1-356 months). Pregnant @entity1 presented more often with thicker @entity320 (median, 2.0 mm vs. 1.7 mm; not statistically significant). No differences with regard to @entity5 location, histologic subtype, @entity5 @entity1066 , or vascular invasion were detected between the pregnant group and the nonpregnant group. There was no statistical difference in the 10-year DFS and 10-year OS rates between the two groups. The 10-year DFS rates for @entity1 in the pregnant and nonpregnant groups, respectively, were 88% versus 86% for @entity1 with @entity320 and 67% versus 73% for @entity1 with @entity320 . The 10-year OS rates for @entity1 in the pregnant and nonpregnant groups, respectively, were 94% versus 90% for @entity1 with @entity320 and 82% versus 81% for @entity1 with @entity320 . CONCLUSIONS: Pregnancy does not appear to have an adverse, long-term effect on survival in @entity1 with clinically localized @entity320 . Further studies should address whether pregnant @entity1 present with thicker lesions and/or whether they have decreased DFS compared with nonpregnant @entity1 . The prognosis for @entity1 with @entity320 during pregnancy, as it relates to survival, still is dependent on @entity5 thickness and @entity1066 .
