Updated meta-analysis of the association between @entity5321 RsaI/ XXXX polymorphisms and @entity2 risk in Chinese population.

@entity9379 @entity2 @entity6746 @entity5321
BACKGROUND: A number of studies have reported relationships of @entity5321 RsaI/ @entity9379 polymorphisms with susceptibility to @entity2 in Chinese population. However, the epidemiologic results have been conflictive rather than conclusive. The purpose of this study was to address the associations of @entity5321 RsaI/ @entity9379 polymorphisms with @entity2 risk in Chinese population comprehensively. MATERIALS AND METHODS: Systematic searches were conducted in the PubMed, Science Direct, Elsevier, CNKI and Chinese Biomedical Literature Databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of association. RESULTS: Overall, we observed a @entity2 risk among subjects carrying @entity5321 RsaI/ @entity9379 c1/ c2 and @entity6746 +c2/c2 genotypes (OR=0.76, 95%CI: 0.64-0.90 and OR=0.78, 95%CI: 0.66-0.93, respectively), as compared with subjects carrying the c1/c1 genotype. In subgroup analysis, we observed a @entity2 risk among @entity6746 carriers in hospital-based studies (OR=0.81, 95%CI: 0.68-0.98) and among carriers with c1/ c2 and @entity6746 +c2/c2 genotypes in population-based studies(OR=0.57, 95%CI: 0.42-0.79 and OR=0.58, 95%CI: 0.43-0.79, respectively), as compared with subjects carrying the c1/c1 genotype. Limiting the analysis to studies with controls in Hardy-Weinberg equilibrium (HWE), we similarly observed a @entity2 risk among @entity6746 and @entity6746 +c2/c2 carriers (OR=0.73, 95%CI: 0.60-0.88 and OR=0.73, 95%CI: 0.60-0.88, respectively), as compared with c1/c1. CONCLUSIONS: Our results suggested that @entity5321 RsaI/ @entity9379 @entity6746 and @entity6746 +c2/c2 variants might be a protective factor for developing @entity2 in Chinese population. Further well-designed studies with larger sample size are required to verify our findings.
