Weight change and healthcare resource use in English XXXX with @entity6 initiating a new @entity6 medication class.

@entity1 @entity6 @entity12489 @entity1017 @entity413
AIMS: The aim of this study was to investigate the association between weight change and healthcare resource use (HCRU) and costs in English primary care @entity1 with @entity6 ( @entity6 ) initiating treatment with a new @entity6 medication class. METHODS: @entity1 diagnosed with @entity6 initiating a new @entity6 medication class (first-line, switch or add-on treatment) were selected from Clinical Practice Research Datalink. Weight change (index date) was measured 6 months after initiating new treatment. HCRU was derived up to 1 year after index. Adjusted analyses evaluated the association between weight change and HCRU and costs ( @entity12489 , 2013 prices). RESULTS: Of 9031 @entity1 , about half (n = 4901) experienced < 3% weight change (weight neutral); the proportions gaining or losing weight were similar. Compared with the weight neutral group, @entity1017 was associated with significantly increased total costs within a year (3.0-5.4% @entity1017 :   58.9; p = 0.01, >=  5.5% @entity1017 :   52.9; p = 0.04) and @entity6 primary care costs (3.0-5.4% @entity1017 :   29.2; p < 0.001, >=  5.5% @entity1017 :   34.2; p < 0.001). This included increased rates of prescribing drugs for @entity6 and, in >=  5.5% @entity1017 , increased primary care contacts. A >=  5.5% weight loss was associated with increased hospital admissions (odds ratio = 1.4; p < 0.0001) and total costs (  126.3; p < 0.001). CONCLUSION: @entity1017 after initiating a new @entity413 -lowering medication is associated with increased prescribing and contact with primary care clinicians, with increased costs in primary care and total spending. This study supports that @entity1017 in @entity6 is associated with increased healthcare costs.
