Radiotherapy as initial treatment for bulky XXXX .

@entity1 @entity137 @entity66 @entity5 @entity44110 @entity34
Sixteen consecutive @entity1 with bulky @entity34 were treated with primary radiotherapy from 1971 to 1982. Bulky @entity34 was defined as either Union Internationale Contre le Cancer (UICC) stage IIC (retroperitoneal metastases greater than 5 cm) or @entity44110 (palpable retroperitoneal metastases) with no evidence of visceral or supradiaphragmatic disease. The median age was 38 years (range, 26 to 52) and the median size of @entity66 was 11.5 cm (range, 5 to 25 cm). @entity1 were treated with generous radiation ports (such as wide hockey-stick or whole abdomen) often followed by boosts to the sites of bulky disease. Median @entity5 dose was 3,235 cGy (range, 2,700 to 5,668 cGy). Mediastinal (with or without supraclavicular) prophylactic radiation was administered to 15 of the 16 @entity1 with a median dose of 2,590 cGy (range, 1,200 to 3,700 cGy). Treatment @entity137 was mild. All 16 @entity1 achieved a complete remission (CR) with radiotherapy. Median follow-up from the time of diagnosis was 60 months, and all @entity1 are currently disease-free. Two @entity1 recurred after therapy but were rendered disease-free with further radiation. These two relapsing @entity1 have remained disease-free, following initial recurrence, for 8 years. The excellent results obtained with modern imaging and radiotherapeutic techniques justify radiotherapy as the initial treatment of choice for bulky @entity34 .
