Exenatide use in the management of XXXX : a retrospective database study.

@entity1 @entity6 @entity1674 @entity4903 @entity209 @entity165 @entity2449
OBJECTIVE: To evaluate the effect of exenatide therapy on cardiometabolic risk factors and anthropometric parameters in @entity1 with @entity209 . METHODS: From June 2005 to June 2007, we performed a retrospective analysis of data extracted from the records of adult @entity1 with @entity209 being treated with exenatide. Diagnosis of any type of @entity6 was exclusionary. @entity1 were initiated on exenatide therapy, 5 mcg, 1 hour before their morning and evening meals for the first month and were instructed to titrate up to 10 mcg. Cardiometabolic risk factors (total @entity165 , high-density lipoprotein @entity165 , @entity1674 , calculated low-density lipoprotein @entity165 , and blood pressure) and anthropometric parameters (absolute body weight, body mass index, and abdominal girth) were measured at baseline and at 16 +/- 4 weeks after initiating exenatide therapy. Data collected also included age, sex, @entity209 diagnosis, and other concomitant medication used in the @entity4903 . RESULTS: The study population consisted of 299 @entity1 (259 @entity1 , 40 @entity1 ) with an age range of 18 to 74 years. Exenatide treatment was associated with significant reductions in mean body weight (P<.001) and body mass index (P<.001). Weight loss in 76.6% of @entity1 was concomitant with a significant reduction in mean abdominal girth (P<.001). Further analysis revealed significant decreases in mean @entity1674 (P<.001), total @entity165 (P<.01), and both systolic (P<.01) and diastolic blood pressure (P<.03). Approximately 60.2% of @entity1 used @entity2449 concomitantly, and half either decreased or discontinued @entity2449 therapy. CONCLUSIONS: This is the first report examining the effect of exenatide on @entity1 with @entity209 . We observed a significant improvement in cardiometabolic risk factors and anthropometric parameters as a result of exenatide over the treatment interval.
