Serial change in 123I-MIBG myocardial scintigraphy in XXXX .

@entity1 @entity2175 @entity6 @entity9208 @entity1503 @entity299 @entity165
PURPOSE: We performed 123I-MIBG (MIBG) myocardial scintigraphy twice in @entity1 with @entity2175 ( @entity2175 ) to investigate whether MIBG distribution was improved by pertinent clinical control. To determine the influential factors for MIBG distribution, we investigated the association between various clinical parameters and the serial change in MIBG uptake parameters. @entity1 AND METHODS: Twenty @entity2175 @entity1 with no @entity299 were evaluated. Planar images were taken at 30 minutes (early) and 3 hours (delayed) after MIBG injection. The heart-to-upper-mediastinum uptake ratio (H/M) and washout ratio (WR) were calculated as parameters for estimating cardiac sympathetic function. @entity1 were divided into two groups, eight in the improved group and twelve in the unimproved group, according to the serial change in H/M. The mean interval between the baseline and the follow up study was 2.1 +/- 0.6 year. Differences between the means of the laboratory data in @entity1 in both groups were compared for the baseline and the follow up study by using the paired t-test. As a means of determining the influential factors for a serial change of MIBG uptake, Fisher's exact test was performed to evaluate the association between the serial change in cardiac MIBG parameters and changes in other clinical parameters, such as @entity1503 ( @entity1503 ) control, @entity1503 control method (insulin therapy), serum @entity165 control, and severity of @entity6 complications. We also analyzed the association between the changes in CV(R-R) (coefficient variance of R-R intervals at rest ECG) or NCV (velocity of posterior tibial nerve) and those of other clinical parameters. Associations among these neurological parameters (MIBG parameters, CV(R-R) and NCV) were also analyzed. RESULTS: Paired t-tests showed a significant decrease in fasting @entity1503 and @entity9208 in the improved group in the follow up study compared to those in the baseline study. Nevertheless, Fisher's exact test showed no significant association between FBS, HbA1C, @entity9208 and the improvement in cardiac MIBG uptake. The only significant association was observed between the serial change in H/M and the @entity1503 -control method (insulin therapy). Within the neurological parameters, a significant association was noted between the serial changes in H/M and CV(R-R). CONCLUSION: Although @entity1503 control was likely to be an important factor, it did not always ameliorate cardiac MIBG uptake. Based on the significant association between the @entity1503 -control method (insulin therapy) and MIBG uptake change, the severity of @entity6 was likely to be a more influential factor. It was suggested that cardiac MIBG uptake could improve within the mild stage if controlled by diet therapy or an oral hypoglycemic agent in @entity2175 .
