Clinical significance of circulating XXXX cells in blood by molecular detection and @entity5 markers in esophageal cancer.

@entity1 @entity5 @entity957 @entity1721 @entity787
BACKGROUND: The clinical significance of circulating @entity5 cells in the blood during surgery has not been elucidated in @entity1721 ( @entity1721 ). We evaluated the relationship between circulating @entity5 cells and clinicopathologic findings, compared with that of serum @entity957 ( @entity957 ) antigen and @entity787 ( @entity787 ), in @entity1721 . METHODS: Blood samples from 54 consecutive @entity1 were obtained from the peripheral artery and the superior vena cava at three points in time: immediately before surgery, and before and after @entity5 resection. @entity787 -specific reverse transcriptase-polymerase chain reaction (RT-PCR), which can quantify circulating @entity5 cells in blood, was performed. The preoperative values of serum @entity957 antigen and @entity787 were also obtained for all @entity1 . RESULTS: @entity787 messenger RNA ( @entity787 mRNA) was detected in the blood of 31 out of 54 @entity1 (57.4%). @entity787 mRNA positivity was detected most frequently after @entity5 resection and correlated with nodal status and stage grouping. The incidence of total recurrence and blood-borne recurrence was significantly greater in @entity1 with @entity787 mRNA positivity than in those with @entity787 mRNA negativity (P =.036 and.0026, respectively). Preoperative serum levels of @entity957 antigen and @entity787 did not correlate with clinicopathologic findings and @entity5 recurrence. CONCLUSIONS: @entity787 mRNA detected by RT-PCR was more predictive of @entity5 recurrence than serum @entity5 markers. Effective adjuvant therapy is recommended for @entity1 with @entity787 mRNA positive expression.
