In vivo effects of XXXX or @entity526 Nissle 1917 on microsatellite instability in @entity31 .

@entity1 @entity124 @entity5 @entity31 @entity876 @entity3504 @entity1344 @entity2983 @entity526
BACKGROUND: @entity124 ( @entity124 ) occurs in chronically inflamed colorectal tissue and may evolve to @entity5 . In vitro data suggest that @entity2983 ( @entity3504 ) improves @entity124 . AIM: To analyse the changes in @entity124 in 156 distal colonic biopsies of 39 @entity1 with @entity31 that had been treated within a randomized, double-blind trial comparing @entity3504 with @entity526 Nissle (EcN). METHODS: Two biopsies had been collected before and after 1 year of treatment. @entity124 testing was performed using a panel of eight markers, including 3 dinucleotide and 5 mononucleotide repeats. RESULTS: No @entity124 was observed with any of the mono-repeats, and among dinucleotide repeats, only D5S346 (maps to APC) and D17S250 ( @entity876 ) were consistently informative. Overall, 31/156 (20%) biopsies displayed @entity124 . After 1 year, 3/11 @entity1 displayed @entity124 improvement [change to @entity1344 ( @entity1344 ); 1 on @entity3504 , 2 on EcN] at D5S346 and 4/11 showed @entity124 worsening (change from @entity1344 to @entity124 ; all @entity3504 ). For D17S250, the corresponding data were for 3/9 @entity1 (2 on @entity3504 , 1 on EcN) and 2/9 (both on @entity3504 ), respectively. CONCLUSIONS: In the set of biopsies taken from @entity1 treated with 1.5 g @entity3504 for 1 year, there was no improvement in the prevalence of @entity124 in the distal colon.
