[Tumor tissue aromatase and XXXX levels versus clinical course of @entity1204 ].

@entity172 @entity1 @entity1204 @entity0 @entity146 @entity5 @entity53
Levels of aromatase, a key enzyme in @entity172 biosynthesis, were assayed in @entity5 tissue sampled from 25 @entity1 with @entity1204 . In addition, @entity53 concentrations were compared in normal and altered endometrial tissue from 78 @entity1 suffering uterine @entity5 . Unlike @entity0 , aromatase was not detectable in altered endometrium unless tissue @entity172 could be identified in both normal and @entity5 tissue. Hence, aromatase presence served as an indicator of malignant transformation. Its concentration in samples of uterine tissue varied 0-28.4 fM/mg protein/hr (an average of 12.9(1.7 fM/mg protein/hr). There was hardly any correlation between this level, on the one hand, and menopause and body mass, on the other. Yet, it tended to increase in step with stage of disease and cell differentiation decline. @entity53 concentrations in malignant endometrium in both reproductive and menopausal @entity1 were higher than in macroscopically normal ones, while still cycling @entity1 tended to show higher values than menopausal ones. Although there was no significant difference in @entity53 levels in the altered endomentrium of @entity1 with pathogenetical patterns of uterine @entity5 stage I and II, they did show a direct correlation with clinical stage of @entity5 process and depth of invasion into the underlying myometrium. Hence, unlike @entity172 circulating in blood, those contained in tissue ("intratumor") ones did enhance the @entity146 of @entity1204 course. It will be for further investigations to show whether it is due to an @entity172 fraction being carried away by @entity5 from the circulation, or @entity172 being synthesized by aromatase in @entity5 itself.
