Calprotectin levels in gingival crevicular fluid predict disease activity in @entity1 treated for generalized aggressive XXXX .

@entity1 @entity2520 @entity548 @entity29 @entity2521
BACKGROUND AND OBJECTIVE: Clinical parameters such as probing depth and @entity548 on probing are commonly used for monitoring after periodontal treatment. However, these parameters have poor prognostic utility. The biomarker calprotectin is used to monitor conditions such as @entity29 because of its ability to predict disease activity. Levels of calprotectin in gingival crevicular fluid correlate with @entity2520 severity and treatment outcome. The validity of calprotectin as predictor for future @entity2520 activity has not yet been investigated. MATERIAL AND METHODS: Thirty-six subjects with generalized aggressive @entity2521 were treated with scaling and root planing (SRP), and with adjunctive antimicrobial medications. Probing depth, clinical attachment level and @entity548 on probing were assessed at baseline, and 3 and 6mo after SRP. A gingival crevicular fluid sample was collected from the initially deepest site in each @entity1 3mo after SRP and analysed for calprotectin levels. Activity was defined as a probing depth increase of >0.5mm between 3 and 6mo at the sample site. The ability of individual parameters to predict activity was analysed by construction of receiver operating characteristic curves. RESULTS: Nine active sites were identified. Clinical attachment level, probing depth, @entity548 on probing and gingival crevicular fluid volume showed no predictive utility [area under the curve (AUC) <0.6, p>0.05]. However, calprotectin concentration (AUC=0.793, p=0.01) and the total amount/sample of calprotectin (AUC=0.776, p=0.02) significantly predicted activity. @entity1 with calprotectin levels above calculated cut-off values had significantly more active sites than @entity1 with negative results. CONCLUSION: Calprotectin levels were predictors of disease activity at both site and subject levels. The calculated cut-off values provide a dichotomous basis for prospective evaluation of calprotectin as a diagnostic marker for monitoring periodontal treatment.
