Differences in Stress Forces and Geometry between Left and Right Coronary Artery: A Pathophysiological Aspect of XXXX Heterogeneity.

@entity1347 @entity453 @entity1642 @entity731
INTRODUCTION: We sought to assess noninvasively the differences in hemorrheologic and geometric parameters between the left and @entity453 ( @entity453 ). Low @entity1642 ( @entity1642 ), high molecular viscosity (MV), and high @entity1642 ( @entity1642 ) induce @entity731 , while curvature and torsion have lately been implicated in the @entity731 process. METHODS: We studied 28 coronary arteries from 22 subjects undergoing coronary computed tomography angiography. We performed 3D reconstruction of the @entity1347 ( @entity1347 , n=14), left circumflex (LCx, n=5), and @entity453 (n=9) arteries. @entity1642 , MV, and @entity1642 were calculated for 2-mm segments using computational fluid dynamics. Curvature and torsion were calculated for each segment using morphometric algorithms. RESULTS: A total length of 187 cm of coronary arteries was studied. @entity1642 was higher in the @entity1347 compared to the LCx and @entity453 (13.76 Pa vs. 3.49 Pa vs. 3.76 Pa, p<0.001); MV was higher in the LCx compared to the @entity1347 and @entity453 (0.00542 Pa  s vs. 0.00173 Pa  s vs. 0.00240 Pa  s, p<0.001); and @entity1642 had higher values in the @entity453 compared to the @entity1347 and LCx (289.98 mmHg vs. 255.93 mmHg vs. 235.18 mmHg, p<0.001). Curvature was greater in the LCx compared to the @entity1347 and @entity453 (0.1447 mm-1 vs. 0.1229 mm-1 vs. 0.1234 mm-1, p<0.05), while torsion was found not to differ among the coronary arteries. CONCLUSIONS: Hemorrheologic and geometric parameters differ between the left and right coronary arteries. These factors, either alone or in association with local flow patterns and geometry, may affect the topography of @entity731 in the coronary arterial tree.
