Applause sign: is it really specific for XXXX ? Evidence from cortical @entity303 .

@entity1 @entity4652 @entity303 @entity75 @entity195 @entity4943 @entity7463 @entity1742
OBJECTIVE: The applause sign, originally reported as a specific sign of @entity7463 ( @entity7463 ), has recently been found in several @entity4652 . Its nature is still uncertain. It has been interpreted as a motor perseveration or a form of @entity1742 . The present study aims to: (a) verify the specificity of the applause sign for @entity4652 , examining the presence of the applause sign in cortical @entity303 which should be error free and (b) clarify the nature of the applause sign (resulting or not from @entity1742 ). METHODS: 77 subjects were included: 10 @entity7463 , 15 @entity4943 ( @entity4943 ), 29 @entity195 ( @entity195 ) and 23 normal controls. The presence of @entity1742 was an exclusion criterion. All @entity1 underwent a detailed neuropsychological examination, and cognitive performance was correlated to the applause sign. RESULTS: All @entity1 groups showed the applause sign and differed significantly from normal subjects who were error free. No difference was found when comparing @entity7463 with @entity4943 and @entity4943 with @entity195 . @entity195 differed significantly from @entity7463 but they were not error free (31% of @entity1 with @entity195 showed the applause sign). The only correlation with background neuropsychology was found for measures of executive functions. CONCLUSIONS: The presence of the applause sign in cortical @entity303 does not confirm the specificity of the applause sign for @entity4652 . The applause sign should be interpreted as a sign of frontal @entity75 rather than a form of @entity1742 , and can likely be detected in any kind of disease which involves frontal lobe structures to some extent.
