Quality of life and menopause: the role of XXXX .

@entity172 @entity1 @entity43 @entity1420 @entity18437 @entity342 @entity3800 @entity25 @entity250
The use of @entity172 or hormone replacement therapy ( @entity18437 /HRT) in preventing disease in menopausal @entity1 has been well documented. Less attention has been paid to the menopausal symptoms that can impair the quality of life of menopausal @entity1 , such as hot flushes, @entity25 , @entity250 , and alterations in mood. Researchers have used a variety of methods to investigate these concerns. @entity43 that occur with menopause have been implicated in these symptoms. Ovarian hormones affect the central nervous system and urogenital tissues directly via receptors for @entity172 , @entity1420 , and @entity3800 . Changes in the symptoms of menopause consequential to @entity172 therapy reflect the effect of this therapy on these tissues. Evidence supporting the effectiveness of @entity18437 /HRT in the treatment of symptoms affecting quality of life is growing and supports the use of @entity18437 /HRT during menopause. Because the most dramatic hormonal changes associated with menopause are related to @entity172 and because @entity172 is usually coadministered with a progestogen in @entity1 with an intact uterus, this review is focused primarily on @entity18437 /HRT. Because @entity342 therapy may also improve quality of life by enhancing perimenopausal and postmenopausal sexual desire, function, and general well-being, a brief discussion of @entity342 supplementation of @entity18437 /HRT is also included. The ideal doses and combinations of hormones must be determined on an individual basis, taking into consideration benefits, risks, and interactions of the different hormone therapies.
