Body Mass Index, Mortality, and Gender Difference in Advanced XXXX .

@entity1 @entity204 @entity740
BACKGROUND AND AIM: A higher body mass index (BMI) appears to be reversely associated with mortality in dialysis @entity1 . Moreover, although @entity1 have better survival in @entity740 ( @entity740 ), this survival advantage is cancelled in dialysis. The association between BMI and mortality and the gender difference remain controversial in advanced @entity740 . METHODS: This study enrolled 3,320 @entity1 (1,938 @entity1 and 1,382 @entity1 ) from southern Taiwan who had @entity740 stages 3-5 with a BMI of 15.0-35.0 kg/m2. RESULTS: During a median 2.9-year follow-up, there were 328 (16.9%) all-cause mortality and 319 (16.5%) cardiovascular (CV) events and @entity204 in male @entity1 , 213 (15.4%) all-cause mortality and 224 (16.2%) CV events and @entity204 in female @entity1 . Compared with the reference BMI of 27.6-30.0 kg/m2 in an adjusted Cox model, lower-BMI groups in @entity1 , BMI 15.0-20.0 kg/m2 and 20.1-22.5 kg/m2, were associated with higher risks of all-cause mortality: hazard ratios (HRs) 3.19 (95% confidence interval [CI], 1.97-5.18) and 2.01 (95% CI, 1.29-3.14), respectively. Higher-BMI group in @entity1 , BMI 30.1-35.0 kg/m2, was associated with a higher risk of all-cause mortality: HR 1.72 (95% CI, 1.02-2.96). Likewise, lower- and higher-BMI groups in @entity1 were associated with a higher risk of CV events and @entity204 . In @entity1 , these associations between BMI and poor outcomes were not observed. CONCLUSIONS: In advanced @entity740 , there was a reverse J-shaped association between BMI and all-cause mortality, and a U-shaped association between BMI and CV outcomes in @entity1 . Neutral associations between BMI and poor outcomes were detected in @entity1 . Gender could modify the effect of BMI on mortality in @entity1 with @entity740 .
