Effects of @entity2727 discontinuation on cerebral blood flow in prepubescent XXXX with @entity71 .

@entity7541 @entity1 @entity71 @entity2727
@entity2727 ( @entity7541 ) is an effective symptomatic treatment of @entity71 ( @entity71 ), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic @entity7541 treatment on regional cerebral blood flow (rCBF) in @entity71 @entity1 . METHODS: Twenty-two prepubescent @entity1 with @entity71 (age range, 8.2-11.5 y) and 7 healthy volunteers were studied with SPECT on and off @entity7541 . Their rCBF data were automatically normalized to whole-brain counts and coregistered with standard anatomic space. rCBF changes were evaluated with statistical parametric mapping based on voxel-by-voxel ANOVA. RESULTS: When the subjects were not taking @entity7541 , rCBF was higher in the motor, premotor, and the anterior cingulate cortices (Brodmann's areas 4, 6, and 32). CONCLUSION: Brief discontinuation of @entity7541 treatment is associated with increased motor and anterior cingulate cortical activity. Our findings suggest that @entity7541 treatment modulates motor and anterior cingulate cortical activity directly or indirectly. Alternatively, our findings may be related to @entity7541 withdrawal. These data provide novel information on the potential mechanisms of the therapeutic action of @entity7541 . Furthermore, they are clinically relevant to the commonly occurring brief interruptions in @entity7541 treatment.
