Expression of intestinal XXXX antigens in the gastric epithelium and its relationship with @entity5 .

@entity1 @entity1944 @entity5 @entity1373 @entity189 @entity3558 @entity105 @entity1141
The expression of large and small intestinal @entity3558 antigens (LIMA and SIMA) was investigated in 30 gastrectomy specimens of @entity189 and in 11 controls resected for various pathologic conditions. One hundred eighty-five samples of normal mucosa, @entity1373 , @entity1944 (types I, II, and III), @entity1141 , and @entity5 were studied to identify phenotypes indicative of premalignant change. Our results showed LIMA and SIMA were not detected in normal gastric epithelium from either control or @entity189 specimens. @entity1 characterized goblet cell @entity3558 in all types of @entity1944 and was not discriminatory between controls and @entity189 groups. On the other hand, LIMA was extensively expressed in columnar and goblet cells in @entity189 (97 per cent) but was absent in controls. There was a crescendo intensity and frequency of LIMA staining in an inverse relation to the degree of cell maturation and differentiation from type I @entity1944 (60 per cent) to type II (85 per cent), type III (100 per cent), and @entity1141 (100 per cent). In contrast, @entity1944 of any type in controls did not show LIMA. The distribution of LIMA seemed to be intimately related to cell differentiation in the proliferative zone at the base of metaplastic glands. @entity189 revealed antigenic phenotype heterogenicity. Our data indicate that LIMA sharpens the diagnosis of @entity1141 , discriminates between reactive and preneoplastic epithelium (particularly within @entity1944 ), and detects abnormal phenotypes that may represent early stages in @entity105 .
