Surgical Resection Improves the Outcome of the XXXX With Neuroendocrine Tumor Liver Metastases: Large Data From Asia.

@entity1 @entity5 @entity3
UNASSIGNED: How to properly manage neuroendocrine liver @entity3 (NELM) remains debatable, and only limited clinical data have been published from Asian population. The objective of this study is to identify possible prognostic factors affecting overall survival time and to provide a guideline for future clinical practice.A retrospective study was performed on 1286 @entity1 who had @entity5 in our specialized center, and data from 130 @entity1 who had NELM were summarized. Demographic and clinicopathologic data, @entity5 grade, treatment method, and prognosis were statistically analyzed.Most of the NELMs originated from pancreas (65.4%). Important prognostic factors that included @entity5 location and size were identified with multivariate analysis. @entity1 with either @entity5 resection or liver @entity3 resection showed a 5-year survival of 35.7% or 33.3%, respectively, whereas resection of both resulted in a 50% 5-year survival. More importantly, resection was performed on 7 @entity1 with grade 3 (G3) @entity5 , and resulted in 1-year, 3-year, and 5-year survival of 100%, 42.8%, and 28.6%, respectively, whereas the other 9 G3 @entity1 without resection died within 3 years. P=0.49 comparing the resected group with nonresected group in G3 @entity1 . Besides, the overall 5-year survival rates for resected and nonresected @entity1 were 40.5% and 5.4%, respectively.Multiple prognostic factors influenced the overall outcome of NELM including @entity1 age, @entity5 location, and size, etc. Aggressive surgical approaches could be considered for maximum survival time disregarding the pathological grade of the @entity5 . Study with larger sample size should be considered to reevaluate the recommendation of the WHO guidelines for G3 @entity5 .
