Balloon valvuloplasty in XXXX : immediate and intermediate outcomes.

@entity1 @entity849 @entity338 @entity6349
OBJECTIVE: To determine the immediate and intermediate outcome in @entity6349 and doming @entity849 in @entity1 and to determine various factors associated with unsuccessful outcome. STUDY DESIGN: An interventional study. PLACE AND DURATION OF STUDY: The @entity1 's Hospital, Lahore, Pakistan, from June 2006 to December 2012. METHODOLOGY: All @entity1 presenting with severe @entity849 were enrolled in the study. Balloon valvuloplasty was performed on all @entity1 . Successful outcome (residual gradient < 36 mmHg) was compared with matched doming @entity849 control group valvuloplasty. Difference in various quantitative variables was calculated using independent t-test and Mann Whitney U test. Categorical variables were compared using Chi square and Kruskal-Wallis test. Multivariate analysis was performed to determine various factors associated with outcome. Kaplan- Meier survival table was used to determine freedom from re-intervention proportions. RESULTS: One hundred and fifty two @entity1 (Dysplastic group A, n=73; Doming group B, n=79) with median age of 24 months (range 3 - 192 months) and M:F; 2:1 were included in the study. Mean gradient decreased from 96    33 mmHg to 29    20 mmHg. Group A had significantly higher number of @entity1 with unsuccessful outcome (9.6%, p=0.02). Preprocedure gradient > 75 mmHg was the most significant factor associated with unsuccessful outcome (p < 0.001). Median follow-up duration was 3 years (range 1 - 6 years). Freedom from re-intervention proportion at 1, 3 and 6 years was 91.3%, 86.7% and 78.9% respectively in group A compared to 100%, 96.5% and 96.5% respectively in group B. Immediate postprocedure gradient > 60 mmHg was the only significant factor associated with re-intervention in group A (p=0.001). CONCLUSION: The results from balloon valvuloplasty in @entity338 were suboptimal when compared to doming valves. However, it provides a high freedom from re-intervention rate in intermediate follow-up. Intervention at moderate severity can result in better outcome.
