Changes in XXXX , antiplasmin, and plasminogen during and after cardiopulmonary bypass.

@entity1 @entity5582 @entity86
Platelet counts and several clotting parameters, especially @entity5582 , alpha 2-antiplasmin, and plasminogen, were determined in 33 @entity1 undergoing cardiopulmonary bypass surgery. Except for Factors VIII and XI, all activities measured fell significantly as the @entity1 were placed on the pump. This initial drop paralleled the drop in hematocrit, i.e., the drop was most likely due to hemodilution. During the entire procedure the activities remained decreased, again paralleling the hematocrit. Only the drop in platelet counts was greater than the hematocrit, suggesting additional consumption during bypass. In the ICU a second significant drop in @entity5582 , prothrombin, and Factor V was noted that was not reflected by a drop in hematocrit. The cause for this is not known at this time. Although the @entity1 with the lowest @entity5582 levels, compared to the highest levels in the ICU seemed to have a greater need for protamine and blood and had greater chest tube drainage, none of these changes were significantly different. Comparisons between activated clotting times (ACTs) and actual heparin levels revealed a good correlation (0.886). Good correlations were also noted when manual factor assays were compared with automated assays using an automated analyzer suggesting the potential use of automation and profiling for these @entity1 . Possible reasons for some of the most commonly encountered @entity86 are discussed.
