Cyst formation and growth in XXXX .

@entity1 @entity8 @entity1127 @entity1373 @entity177 @entity2543 @entity8767 @entity652 @entity3257
Previous morphologic studies on kidneys from adult @entity1 with @entity8 ( @entity8 ) indicates that the cysts developed from nephrons and collecting ducts in association with @entity1373 of epithelial cells lining the cyst walls. In the present study, we systematically evaluated by scanning electron microscopy 387 cysts in @entity8767 from 10 adult @entity1 . Some cysts were lined by cells typical of collecting duct (7.2%), proximal tubule (1.8%) or glomerular visceral (2.1%) epithelium. The remaining cysts were lined by a single layer of phenotypically undefined (84.0%) or markedly hyperplastic (4.9%) epithelium. The median plane surface area of individual cells within cysts was 182 X 10(-8) cm2. Among all cysts the surface area of single epithelial cells ranged between 22 and 2530 X 10(-8) cm2, but within single cysts the range of individual cell surface areas was more narrow. Mean cell surface area did not increase in direct proportion to cyst diameter; thus, @entity2543 is a central element in the progressive enlargement of cysts. In some @entity1373 was accentuated by projections into cyst lumens of @entity1127 , small @entity652 and cord-like arrangements of cells. Epithelial @entity1127 were found in the cysts of one @entity3257 @entity1 , excluding @entity177 as a cause of this accentuated type of epithelial proliferation. Morphologic evidence that cysts compressed adjacent renal parenchyma was observed in all kidneys. In 11 cysts bisected and then both halves thoroughly examined by scanning electron microscopy, one or two tubule openings were seen in one of the hemisections in three cysts (27.3%).(ABSTRACT TRUNCATED AT 250 WORDS)
