Hemispherical focal macular photopic negative response and macular inner retinal thickness in XXXX .

@entity1 @entity227 @entity1538 @entity4494 @entity726 @entity655
PURPOSE: To investigate in @entity1538 the focal macular photopic negative response and spectral-domain optical coherence tomography measurements of retinal thicknesses in the superior and inferior macula. DESIGN: Comparative case series. METHODS: We studied 63 eyes of 63 @entity1 with @entity1538 and 41 normal eyes of 41 volunteers. Photopic negative responses were recorded using a spotlight (diameter of 15 degrees of circle), projected onto the whole or superior or inferior macula. Ganglion cell complex (nerve fiber + @entity4494 cell + inner @entity655 ) thickness was measured using spectral-domain optical coherence tomography. RESULTS: Mean photopic negative response amplitude over the entire macula was significantly (P < .001) decreased compared with that of controls in eyes with early (n = 24; to 62.1%), moderate (n = 21; to 57.2%), and severe (n = 18; to 49.3%) @entity1538 , but not significantly different among eyes with various stages of @entity726 . Mean @entity4494 cell complex thickness was significantly (P < .001) decreased compared with that of controls in eyes with early (86.0%), moderate (78.3%), and severe (71.2%) @entity726 , and thinning correlated positively with @entity726 severity (P < .001). Mean photopic negative response amplitude correlated significantly (P < .001) with @entity4494 cell complex thickness over the whole, superior, and inferior macular areas (r = 0.57 to 0.74). In 16 eyes without @entity227 in the inferior hemifield, mean photopic negative response amplitude was 56.5% of normal (P < .001), and mean @entity4494 cell complex thickness in the superior macula was 92.1% of normal (P = .004). CONCLUSIONS: Focal macular photopic negative response amplitude correlates with @entity4494 cell complex thickness, but decreases more abruptly in early @entity726 compared with @entity4494 cell complex thickness.
