The heart in XXXX . The Cooperative Study of @entity3458 (CSSCD).

@entity1 @entity296 @entity5988 @entity1184 @entity3458
The objective of this study was to obtain representative echocardiographic measurements of cardiac size and function in stable @entity1 with @entity3458 . This prospective, multicenter study utilized central reading of echocardiograms by an investigator blinded to other @entity1 data. Stable outpatients from a balance of inner city and rural settings with SS phenotype and a broad age range were selected, because conflicting results from earlier studies were believed to be due to these @entity1 selection criteria. Right and left ventricular dimensions and wall thickness, left atrial and aortic root dimensions, and systolic time intervals were measured. Body surface area indexed chamber dimensions and septal thickness were significantly increased from normal. Except for the right ventricle, chamber dimensions and wall thickness were inversely correlated with hemoglobin. The relationship between left ventricular dimension and hemoglobin was significantly dependent on age. Systolic time interval ratios were normal though left ventricular ejection time was prolonged. Shortening fraction was normal but velocity of circumferential fiber shortening was abnormally low. Stable @entity1 with @entity3458 have dilated chambers, @entity1184 , and normal contractility. Though @entity5988 was inversely related to hemoglobin, age (duration of illness) was an important factor in that relationship. No specific @entity296 was associated with @entity3458 .
