Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against @entity2275 in XXXX .

@entity1 @entity548 @entity1865 @entity5 @entity39 @entity568 @entity2625 @entity2041 @entity1505 @entity6172 @entity1234 @entity842 @entity3426 @entity356 @entity35 @entity224 @entity1068 @entity4546 @entity2275
@entity2275 are among the most common diseases affecting @entity1 . This study aimed at investigating the gastroprotective effects of manuka honey against @entity1068 -induced @entity2275 in @entity35 . The mechanism by which honey exerts its antiulcer potential was elucidated. Four groups of @entity35 were used: control, @entity1068 (ulcer), @entity4546 , and manuka honey. Stomachs were examined macroscopically for @entity548 in the glandular mucosa, histopathological changes, and glycoprotein detection. The effects of oxidative stress were investigated using the following indicators: gastric mucosal @entity842 (NO), @entity2041 ( @entity6172 ), lipid @entity2625 ( @entity1865 , measured as @entity1234 ) @entity2041 peroxidase (GPx), @entity224 dismutase (SOD), and catalase. Plasma @entity5 @entity39 factor-a, @entity3426 , and @entity568 were also measured. Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved @entity356 . It significantly increased gastric mucosal levels of NO, @entity6172 , GPx, and SOD. Manuka honey also decreased gastric mucosal @entity1865 and plasma @entity1505 , @entity3426 , and @entity568 concentrations. In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic ( @entity6172 and NO) antioxidants as well as inflammatory cytokines ( @entity1505 , @entity3426 , and @entity568 ) in a reduced form, inhibited lipid peroxidation ( @entity1865 ), and preserved mucous glycoproteins levels.
