Clinical characteristics of multiple primary XXXX .

@entity1 @entity6461 @entity1697 @entity5 @entity957 @entity189
OBJECTIVES: This study aimed to clarify the clinical characteristics of multiple primary @entity1697 . MATERIALS AND METHODS: We retrospectively reviewed the cases of 1015 @entity1 who were treated during follow up for @entity5 at Tokyo Medical and Dental University between March 2001 and December 2012. We compared the clinical characteristics of 961 @entity1 who developed single primary @entity957 ( @entity6461 ) during follow up and 54 @entity1 who subsequently developed multiple primary @entity189 in the oral cavity. RESULTS: Mean age at first diagnosis was significantly higher in @entity1 with multiple primary @entity189 . Multiple primary @entity189 showed a female predilection, were most prevalent in the gingiva, and tended to show @entity5 and nodal stages than single primary @entity189 . The local recurrence rate was higher for multiple primary @entity189 , and it increased with the number of multiple primary occurrences. The disease-specific survival rate at 10years for @entity1 with single primary @entity189 was 85.3% and that for @entity1 with multiple primary @entity189 was 79.6%. The cumulative incidence rate for metachronous second multiple primary @entity189 after the onset of first @entity189 at 10years was 8.0%. The recurrence of multiple primary @entity189 did not decrease the survival rate. CONCLUSION: Differences were found in the clinical characteristics between @entity1 with single oral @entity6461 and those with multiple primary @entity1697 . Early diagnosis and treatment as well as close long-term follow up are needed for @entity1 with multiple primary @entity1697 .
