XXXX in pediatric heart transplant recipients.

@entity1 @entity1565 @entity4595 @entity1576 @entity1729 @entity386
BACKGROUND: The frequency and spectrum of chronic @entity1576 in pediatric heart transplant recipients have not been extensively studied. The aim of this study was to describe the chronic @entity1576 in 126 consecutive pediatric heart transplant recipients. METHODS: Retrospective review of medical records. RESULTS: Between 1987 and 2005, 126 (64 males and 62 females) heart transplantations were performed at Freeman Hospital, Newcastle upon Tyne, United Kingdom. The median age at transplantation was 7.4 years (range, 0.1-17) and the median length of follow-up was 6.8 years (range, 0-18.2). Twenty-four @entity1 have died, and 36 have been transferred to adult follow-up, leaving 66 under pediatric follow-up. @entity1576 have been documented in 33 @entity1 (50%). @entity4595 has been identified in 10 @entity1 , and 12 further @entity1 have had recurrent lower @entity1729 (without @entity4595 ) requiring long-term antibiotic prophylaxis. Of those with infectious complications, 81% underwent transplantation before 4 years and had deficiency of pneumococcal-specific antibody response. Obstructive sleep @entity386 has occurred in 5 @entity1 , sub-glottic stenosis has occurred in 3, and significant compression of the left main stem bronchus related to a disproportionately large donor heart has occurred in 2. One @entity1 had marked mosaic attenuation on chest computed tomography scan indicative of @entity1565 . CONCLUSION: @entity1576 are common in pediatric heart transplant recipients. The respiratory prognosis for this complex group of @entity1 is usually good, but long-term follow-up by both a respiratory pediatrician and an immunologist is frequently required.
