Evaluation of voice and quality of life after transoral endoscopic laser resection of early XXXX .

@entity1 @entity6475 @entity5 @entity189
OBJECTIVE: This study aimed to evaluate voice and quality of life after transoral laser resection of early @entity189 . METHODS: We studied 19 @entity1 undergoing transoral laser resection of @entity5 stage (T) one or T2 @entity189 . Laryngeal function was evaluated by video-stroboscopy, vocal function by the Voice Symptom Scale, the grade-roughness-breathiness-asthenia-strain scale and objective phoniatric assessment, and quality of life by the University of Washington Quality of Life questionnaire. RESULTS: @entity1 ' @entity189 @entity5 -node-metastasis (TNM) staging was T1 N0 M0 in 14 @entity1 and T2 N0 M0 in five. Overall voice grade, roughness and breathiness were mild to moderate in 84 per cent; asthenia and @entity6475 were more uniformly distributed, with 15 per cent of @entity1 having normal voice quality. Eight @entity1 developed a glottic web post-operatively; anterior commissure web was significantly associated with worse voice grade (p = 0.05). Seven @entity1 (47 per cent) had a 'mucosal wave' on the operated vocal fold; this was significantly associated with less strain on phonation (p = 0.05). Voice Symptom Scale score was low overall (15 @entity1 (78.9 per cent) scored less than 30). The fundamental frequency and frequency irregularity were normal in nine @entity1 (47.3 per cent); the closed quotient was normal in six (31.5 per cent). The averaged quality of life score was >=  90 in 14 @entity1 (73.7 per cent); 18 (94.7 per cent) felt their health-related quality of life was either the same or better post-operatively; and overall quality of life was positive in all. CONCLUSION: Transoral laser resection of T1 and T2 @entity189 enables adequate @entity5 tissue excision with preservation of acceptable vocal function. Most @entity1 ' post-operative quality of life is very good. Anterior commissure web formation is associated with poorer vocal function.
