Experimental XXXX induced by a clinical @entity23009 isolate.

@entity1 @entity825 @entity9463 @entity627 @entity625 @entity95 @entity23009 @entity309
BACKGROUND: @entity23009 has been associated with @entity309 . Recently, it was detected in the joints and blood of @entity1 with @entity309 , but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of @entity23009 to induce experimental @entity625 in @entity95 following inoculation of the bacteria in the @entity825 and knee joints. METHODS: P-140 and PG-18 strains were each injected in the knee joints of 14 @entity95 in order to evaluate and compare their arthritogenicity. P-140 was also injected in the @entity825 of 14 @entity95 in order to test the ability of the bacteria to reach the joints and induce @entity625 . RESULTS: @entity23009 produced an acute @entity625 in @entity95 . Joint swelling appeared first in @entity95 injected with P-140, which caused a more severe @entity625 than PG-18. Both strains were able to migrate to the uninoculated knee joints and they were detected viable in the joints all along the duration of the experiment. Changes in the synovial tissue were more severe by the end of the experiment and characterized by the infiltration of neutrophils and substitution of adipose tissue by connective tissue. @entity95 intracheally injected with P-140 showed induced @entity625 and the bacteria could be isolated from lungs, blood, heart, kidney, spleen, brain and joints. CONCLUSION: @entity23009 induced @entity625 regardless of the inoculation route. These findings may help explain why @entity9463 are commonly isolated from the joints of @entity627 @entity1 .
