The effects of controlled XXXX therapy on ventricular function in @entity1 with stable and decompensated @entity3618 .

@entity1 @entity3618 @entity4 @entity26 @entity120 @entity1030 @entity4266
We made simultaneous measurements of pulmonary hemodynamics, cardiac output, and @entity4266 ( @entity4266 ) to assess the right ventricular function in 14 @entity1 with @entity120 as a result of @entity1030 ( @entity1030 ). From these measurements, the right ventricular end-systolic pressure/volume relationship could be calculated and used to assess right ventricular contractility. Eight of the @entity1 were clinically stable, without @entity4 , and 6 presented acutely with gross @entity4 , indicating decompensated @entity3618 . Measurements were made at rest, while breathing air and @entity26 . Although mean pulmonary arterial pressure (Ppa) was similar in those with (Ppa = 33 +/- 6 mm Hg) and without @entity4 (Ppa = 30 +/- 8 mm Hg, p greater than 0.05), @entity4266 was lower in @entity4 ( @entity4266 = 0.23 +/- 0.11) compared with non- @entity4 @entity1 ( @entity4266 = 0.47 +/- 0.04, p less than 0.01). Cardiac output was normal in both groups. The mean right ventricular end-systolic pressure/volume ratio (P/V) was lower in those @entity1 with @entity4 (P/V = 0.41 +/- 0.27), as compared with those without @entity4 (P/V = 1.69 +/- 0.35, p less than 0.05), as a result of an increase in right ventricular end-systolic volume index. Similarly, left ventricular end-systolic volumes were higher in @entity4 than in non- @entity4 @entity1 . Breathing 1 to 3 L/min of @entity26 for 30 min decreased total pulmonary vascular resistance (p less than 0.05) in those @entity1 without @entity4 , but not in @entity1 with @entity4 . @entity26 did not change @entity4266 , left ventricular ejection fraction (LVEF), or the ventricular end-systolic P/V relationships.(ABSTRACT TRUNCATED AT 250 WORDS)
