[Comparative study of functional and structural changes produced in a porcine model of acute and chronic XXXX ].

@entity1707 @entity63 @entity1563 @entity1188 @entity2224 @entity299 @entity583 @entity943
INTRODUCTION AND OBJECTIVES: Animal models are a useful tool for the evaluation of disease mechanisms and also for technologies for diagnosis and treatment. In this study we performed a descriptive analysis of the functional and structural cardiac changes occurred as a result of acute @entity1563 in @entity1707 and its evolution during 5 weeks. METHODS: 19-Large White @entity1707 , weighing 20kg, randomized into 3-experimental series were used. After sternotomy, anterior descending coronary artery was occluded. Duration of occlusion: Series 1 (n=6) 60min; series 2 (n=8) 90min; series 3 (n=5) 60min followed for 5 weeks. The following parameters where then analyzed: global cardiac function (ECG, left ventricular and atrium pressures, aortic flow and @entity299 ), regional contractility, troponin T and CK-MB levels, macroscopic and histological analyzes. RESULTS: @entity1563 transiently altered the global cardiac function and produced increased cell damage markers, impaired regional contractility and produced histological changes. The increment of ischemic time (60 vs. 90min) increased @entity1188 size (13.4  5.4% vs. 22.9  7.8 S1 S2%; P=.04). After 5 weeks, morphological remodelling changes were evident. In 79% of cases @entity63 triggered @entity2224 . CONCLUSION: The porcine open chest model of @entity583 and reperfusion is valid for studying the pathophysiology of @entity63 , allows direct analysis of regional myocardial function and is easily retrievable in the event of serious @entity943 .
