Clinicopathological features and management of XXXX in Pakistan: a prospective study of 233 cases.

@entity1 @entity1085 @entity390 @entity353 @entity1087 @entity5 @entity391 @entity189 @entity15449 @entity1442 @entity158 @entity1086 @entity3 @entity1682
BACKGROUND AND AIMS: @entity1086 is common in Pakistan and has an extremely poor prognosis. Treatment is primarily surgical. Chemotherapy is frequently used in @entity1 with @entity1442 . This study was performed to evaluate and compare the clinicopathological features and management of @entity1086 in @entity15449 @entity1 , with particular emphasis on factors that influence survival. METHODS: Two hundred and thirty-three @entity1 with histologically proven @entity1086 were studied. Information was prospectively collected on demographic features, clinical and laboratory findings at the time of presentation, influence of therapy, and survival. Data were analyzed to evaluate variables that influenced survival. Kaplan-Meier analysis was used to calculate survival. RESULTS: Most @entity1 were @entity1 (77%). Mean age was 55 years (+/-11 years). Fourteen per cent of females were nulliparous. Twenty-six per cent had five or more @entity1 . Only 4% of @entity1 had a documented history of @entity1682 . The majority (69%) had a history of symptomatic @entity1085 . The commonest presenting symptom was @entity158 (89%), followed by @entity390 and @entity391 (52%), @entity353 (42%), and @entity1087 (33%). One-quarter of @entity1 had a palpable abdominal mass. Most had abnormal hepatic function tests and 58% had @entity189 embryonic antigen levels. Stage (P < 0.001), @entity1087 (P = 0.01) and palpable mass (P = 0.02) were statistically significant variables. However, on multivariate analysis, @entity5 node @entity3 (TNM) stage was the only factor influencing survival. Median survival of the @entity1 was 44 months for @entity1 with stage I disease, 23 months for stage II, 17 months for stage III and 6 months for stage IV. CONCLUSION: These data are comparable with those reported from other developing countries. Most @entity1 presented at an advanced stage of disease and had an extremely poor prognosis. Systemic therapy did not provide any survival benefit. The TNM stage remains the most important factor influencing survival.
