Glycemic and XXXX Control Versus Single-Goal Control in US Veterans with Newly Diagnosed Type 2 Diabetes: A Retrospective Observational Study.

@entity1 @entity4051 @entity6 @entity5748 @entity164 @entity65 @entity165
INTRODUCTION: A majority of @entity1 with @entity6 do not have levels of glycated hemoglobin (HbA1c) and low-density lipoprotein @entity165 (LDL-C) under control, either individually or in combination. The objective was to assess the clinical benefits and @entity1 characteristics associated with @entity5748 [HbA1c <7% (53  mmol/mol) and LDL-C <100  mg/dL] versus only LDL-C goal achievement in adults with newly diagnosed @entity164 2 @entity6 . METHODS: Newly diagnosed @entity1 with >= 2 measures of LDL-C and @entity4051 c were identified in the South Central Veterans Affairs Health Care Network (01/2004-06/2010). The index date was the first @entity4051 c assessment within 3  months of the first @entity164 2 @entity6 diagnosis. Multivariate Cox proportional hazards models were used to assess the association between time-varying goal achievement and post-index microvascular and @entity65 . @entity1 characteristics associated with @entity5748 in the 7-12  months post-index were identified using a logistic regression. RESULTS: The sample included 16,829 @entity1 . Compared with LDL-C goal achievement, @entity5748 was associated with lower risk of microvascular complications [hazard ratio (95% confidence interval): 0.69 (0.63, 0.76)]. Other outcomes did not differ between those two groups. Characteristics associated with @entity5748 (44.2% of @entity1 ) include prior @entity5748 , older age, and use of lipid-lowering drugs. CONCLUSION: @entity5748 in newly diagnosed @entity164 2 @entity6 is associated with a lower risk of microvascular complications versus only LDL-C goal achievement. Although @entity5748 rates are suboptimal, early and regular intervention will increase its likelihood. FUNDING: Daiichi Sankyo, Inc., Parsippany, NJ, USA.
