Disturbances of Modulating Molecules ( @entity403 , @entity4386 / @entity1361 /B7, and @entity2936 / XXXX ) mRNA Expressions in the Orbital Tissue from @entity1 with Severe Graves' Ophthalmopathy.

@entity1 @entity2937 @entity2743 @entity7938 @entity1361 @entity2936 @entity11603 @entity403 @entity4386 @entity1851
Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity403 , @entity4386 / @entity1361 / @entity7938 / @entity2937 , and @entity2936 / @entity2936 and the severity of @entity2743 ( @entity2743 ). Material and Methods. Orbital tissue was obtained from 26 @entity1 with @entity2743 , with mild (n = 6) or severe @entity2743 (n = 20), and 7 healthy controls. The expression of mRNA of @entity403 , @entity4386 / @entity1361 / @entity7938 / @entity2937 , @entity2936 / @entity11603 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity403 (relative expression: 1.4) and @entity2936 (1.27) and lower expression of @entity4386 (0.61) were found in the @entity2743 tissues versus controls. In severe @entity2743 as compared to mild @entity2743 higher mRNA expression for @entity403 (1.35) and @entity2936 (1.4) and lower expression for @entity4386 (0.78), @entity1361 (0.62), and @entity11603 (0.56) were found. A positive correlation was found between @entity403 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity403 mRNA expression in @entity2743 samples may suggest the dysfunction of @entity403 cells in the severe @entity2743 . The diminished mRNA expression of @entity4386 in severe @entity2743 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity2936 in severe @entity2743 and negative correlation to @entity1851 mRNA may suggest their role in the active and inactive @entity2743 .
