[Experimental study of fluorosis in XXXX ].

@entity5428 @entity3163 @entity742 @entity2862 @entity460 @entity3151 @entity1388 @entity1760
Eighty-four @entity742 weaned at birth were randomised to three groups, each of 28 animals. The amount of @entity1388 contained in the feed was carefully assessed. Two groups were administered with @entity3163 . The dose was calculated so as to administer a quantity of @entity1388 close to the quantity that @entity742 would ingest in consuming alfalfa containing from 125 to 250 ppm @entity1388 . The daily amount of @entity1388 administered to the 1st group rose progressively between week 3 and week 8 from 0.45 to 2 mg/kg/day, then remained fixed until the animals were slaughtered. Group 2 received double amounts: from 0.90 mg/kg/day to 4 mg/kg/day between week 3 and week 8, at which level the amount was fixed. The treatment had no effect on the growth of the @entity742 : at week 17 their average weight was about 29 kg. Plasma levels of ionic @entity2862 rose steadily up to week 9, at which they remained fixed at about 0.40 mg/l in group 1 and 0.75 mg/l in group 2, whereas they ranged between 0.10 and 0.15 mg/l in the controls. Ionic @entity2862 averaged 28% of the total @entity1388 in the controls, 42% in group 1 and 47% in group 2. @entity1388 levels in the bones were very high (up to 2760 ppm in the mandibles in group 2). Reversely, @entity1388 levels in the muscles were very low: 1.00 ppm in group 2. The biochemical paremeters @entity460 , @entity3151 , @entity1760 , transaminases, phosphatases and @entity5428 transferases greatly varied in relation to the age of the animal but were not affected by @entity1388 intake.
