@entity3237 modulates nutrient reward via inhibitory XXXX action on orexin neurons.

@entity18070 @entity935 @entity19 @entity3237 @entity17234 @entity969 @entity2339 @entity40335
OBJECTIVE: @entity3237 modulates food reward via central @entity3237 receptor ( @entity18070 ) expressing neurons. Food reward requires stimulation of midbrain @entity935 neurons and is modulated by central @entity3237 action, but the exact central mechanisms remain unclear. Stimulatory and inhibitory @entity3237 actions on @entity935 neurons have been reported, e.g. by indirect actions on orexin neurons or via direct innervation of @entity935 neurons in the ventral tegmental area. METHODS: We showed earlier that @entity18070 neurons in the @entity2339 ( @entity2339 ) co-express the inhibitory acting neuropeptide @entity17234 (GAL- @entity18070 neurons). We studied the involvement of GAL- @entity18070 neurons to regulate nutrient reward in @entity19 with selective @entity18070 deletion from @entity17234 neurons (GAL- @entity18070 (KO) @entity19 ). RESULTS: We found that the rewarding value and preference for @entity969 over fat was increased in GAL- @entity18070 (KO) @entity19 compared to controls. @entity2339 GAL- @entity18070 neurons innervate orexin neurons, but not the VTA. Further, expression of @entity17234 and its receptor @entity40335 are decreased in the @entity2339 of GAL- @entity18070 (KO) @entity19 , resulting in increased activation of orexin neurons. CONCLUSION: We suggest @entity17234 as an important mediator of @entity3237 action to modulate nutrient reward by inhibiting orexin neurons.
