Variability of effluent cancer antigen 125 and @entity650 determination in @entity298 XXXX .

@entity1 @entity650 @entity298 @entity10224
BACKGROUND: Cancer antigen (CA) 125 is a glycoprotein that provides data on the state of the peritoneal membrane in @entity298 ( @entity298 ). @entity650 ( @entity650 ) acts as a mediator in acute-phase responses. The study evaluated the usefulness of @entity10224 and @entity650 in random effluent samples, by assessing their variability in individual @entity1 during clinical practice at the outpatient department. METHODS: This longitudinal prospective study was conducted from 2007 till 2009. @entity1 included 52 stable @entity298 @entity1 aged >=  18 years. Effluent samples were obtained during regular outpatient visits and appearance rates (ARs) were calculated. Inter- and intra-individual variability was determined by the coefficient of variation (CV). A linear mixed model was used to analyse time courses. Furthermore, release patterns of these effluent markers were studied. RESULTS: @entity10224 -AR of short-term @entity1 ( <= 24 months) ranged from 39.2 to 766.7 U/min and @entity650 -AR from 15.5 to 220.0 pg/min. Long-term @entity1 (>=  25 months) had a @entity10224 -AR of 7.3-1534.0 U/min and @entity650 -AR of 6.9-956.4 pg/min. Overall, CV(intra) was 15% in effluent @entity10224 -AR and 28% in @entity650 -AR. Intermediate sampling during a 4-h dwell showed a linear increase of @entity10224 and @entity650 effluent concentrations. The trend of @entity10224 -AR was different (P = 0.001) between short- and long-term @entity1 . A negative relationship was found between @entity10224 (r = -0.44, P = 0.02) and @entity298 duration. CONCLUSIONS: The clinical relevance of effluent @entity10224 determinations from an unstandardized dwell during every outpatient visit is reasonable, as judged from the CV(intra). The inferior CV(intra) values of ARs as compared to effluent values indicate that ARs should only be calculated under standardized conditions. A single @entity650 measurement, as a predictor of outcome, should be interpreted cautiously.
