Prognostic importance of hypodiploid hemopoietic precursors in XXXX .

@entity1 @entity2007 @entity981 @entity417 @entity2590 @entity236 @entity1778 @entity2008
It has been suggested that a poor prognosis and the development of @entity1778 in @entity1 with @entity2590 may be related to @entity2008 . We measured the DNA content of bone marrow cells with flow cytometry in 19 hematologically normal subjects and in 70 @entity1 who had recently been diagnosed as having @entity2590 . Thirty-four of the @entity1 were found to have @entity2007 . This was not related to the percentage of blast cells in the bone marrow, and there was no demarcation in terms of DNA content between @entity1 with a high percentage of blast cells and those with a low percentage of such cells. @entity1 with @entity236 had a significantly shorter survival time than other @entity1 (P = 0.001). @entity1 with @entity981 marrow and those whose marrow had a normal DNA content had similar survival times. Hypodiploidy appears to be a better indicator of poor survival than the marrow blast-cell count. @entity1 with @entity417 invariably had cells with a normal or high DNA content; none of these @entity1 died during the study. Our data suggest that there is a relation between the loss of chromosomal material and progression toward a @entity1778 phenotype. It is tempting to speculate that this process may involve a loss of negative regulatory genes ("anti-oncogenes").
