XXXX infusion during middle ear surgery under general anaesthesia to provide oligaemic surgical field: A prospective study.

@entity1 @entity548 @entity1337 @entity5161 @entity6948
BACKGROUND AND AIMS: Middle ear surgery requires bloodless surgical field for better operating conditions, deep level of anaesthesia and rapid emergence. Recent studies suggest that a2 agonists could provide desired surgical field, sedation and @entity1337 . The present study was aimed to evaluate the clinical effects of @entity6948 infusion as anaesthetic adjuvant during middle ear surgery using operating microscope. METHODS: Sixty four adult @entity1 aged 18-58 years, American Society of Anaesthesiologists Grades I and II, of both gender were randomised into two comparable equal groups of 32 @entity1 each for middle ear surgery under general anaesthesia with standard anaesthetic technique. After induction of general anaesthesia, @entity1 of Group I were given @entity6948 infusion of 0.5  g/kg/h and @entity1 of Group II were given placebo infusion of normal saline. @entity5161 concentration was titrated to achieve a systolic blood pressure 30% below the baseline value. All @entity1 were assessed intra-operatively for @entity548 at surgical field, haemodynamic changes, awakening time and post-operative recovery. RESULTS: Statistically significant reduction was observed in the required percentage of @entity5161 (0.8    0.6%) to maintain the systolic blood pressure 30% below the baseline values in @entity1 receiving @entity6948 infusion when compared to those receiving placebo infusion (1.6    0.7%). @entity1 receiving @entity6948 infusion had statistically significant lesser @entity548 at surgical field (P < 0.05). The mean awakening time and recovery from anaesthesia did not show any significant difference between the groups. CONCLUSION: @entity6948 infusion can be safely used to provide oligaemic surgical field for better visualization using operating microscope for middle ear surgery.
