XXXX in East Yorkshire: A case series and literature review of current management.

@entity5 @entity3852 @entity1 @entity1600
INTRODUCTION: @entity3852 ( @entity3852 ) is a rare, @entity5 of the skin. The incidence is rising and it is associated with sun exposure and immunosuppression. Our aim was to perform a 10-year retrospective review of @entity3852 treated in East Yorkshire and to examine disease progression, surgical and adjuvant management, and outcomes. METHODS: A 10-year retrospective review was undertaken of @entity1 identified through the histopathology database. Case notes and digital @entity1 records were examined for @entity1 demographics, disease characteristics, management and outcome. Disease stage was calculated using the 2010 AJCC TNM classification. RESULTS: Thirty-seven @entity1 with complete records were included. Twenty-one @entity1 were male and 16 female, with mean age 76.7 years at presentation. Pre-malignant or malignant skin changes were documented in 15 @entity1 , and immunosuppression in 15 @entity1 . Mean duration of lesion was 17.5 weeks. Following diagnosis 22/37 @entity1 underwent further surgery with 11 @entity1 undergoing sentinel @entity1600 ( @entity1600 ) biopsy. @entity1600 was palpable at presentation in 8 @entity1 . Three year survival is 40%. CONCLUSIONS: There is no standardised management of @entity3852 and randomised trials are challenging due to relatively small numbers. There has been little progress made in terms of improving survival. Development of a national database for @entity1 with this condition would allow prospective data collection and more accurate assessment of current treatment protocols and their efficacy. Level of Evidence: IV.
