Risk of XXXX in the columnar cuff after stapled restorative proctocolectomy.

@entity1 @entity32 @entity5 @entity31 @entity189 @entity1141
BACKGROUND: Stapled restorative proctocolectomy (SRP) for @entity31 retains a 'cuff' of columnar epithelium, which carries a risk of undergoing malignant change. The risk of @entity5 was studied in a series of @entity1 who underwent SRP for @entity31 . METHODS: One hundred and thirty-five @entity1 who underwent SRP for @entity31 between 1988 and 1998 were followed up by cuff surveillance biopsy. The median follow-up was 56 (range 12-145) months and the median time since diagnosis of @entity31 was 8.8 (range 2-32) years. RESULTS: The cuff biopsies showed no @entity1141 or @entity189 . The accuracy of obtaining cuff mucosa in the biopsy was 65 per cent. @entity32 was present in 94 per cent of cuff biopsies. CONCLUSION: This study shows no evidence of either @entity1141 or @entity189 in the columnar cuff mucosa, up to 12 years after pouch formation. This suggests that cuff surveillance in the first decade after SRP, in the absence of @entity1141 or @entity189 in the original colectomy specimen, may be unnecessary. Regular cuff surveillance biopsies after SRP should continue for @entity1 with high-grade @entity1141 or @entity189 in the original resection specimen.
