Metallic ion content and damage to the DNA in oral mucosa cells of XXXX with fixed orthodontic appliances.

@entity1 @entity3406 @entity921 @entity68 @entity3407 @entity702 @entity1953 @entity15 @entity5334
Although the metal devices used in orthodontic treatments are manufactured highly resistance to corrosion, they may still suffer some localized corrosion resulting from the oral cavity conditions. The corrosion causes the release of metals from the alloys used for their manufacture. In this report, we evaluated the in vivo metal ions release of three alloys (stainless steel, @entity702 and @entity3406 -free) usually used in the orthodontics treatments and its genotoxicity. We applied to 15 @entity1 , between 12 and 16 years, 4 tubes and 20 brackets. Samples from oral mucosa were taken before the treatment and 30 days later. The concentration of the @entity702 , @entity3407 , @entity921 , @entity1953 , @entity3406 , @entity5334 and @entity68 were detected using inductively coupled plasma mass spectrometry (ICP- @entity15 ). The genotoxicity was measured with a comet assay (Olive moment). The oral mucosa cells in contact with the stainless steel alloy displayed the greatest @entity702 and @entity921 concentrations and those in contact with the @entity3406 -free alloy presented the greatest concentration of @entity3407 and @entity68 . Both alloys, stainless steel and @entity3406 -free, induced a higher DNA damage in the oral mucosa cells than the @entity702 alloy, in which the Olive moment was similar to controls. Based on the results of our study, we can conclude that @entity702 brackets and tubes are the most biocompatible of the three alloys.
