Subthalamic nucleus stimulation improves @entity191 in parallel to its preoperative XXXX responsiveness.

@entity1 @entity3518 @entity3034 @entity191
OBJECTIVE: The aim of this work was to identify factors predictive of postoperative improvement of @entity3518 in @entity1 with @entity191 ( @entity191 ) treated by subthalamic nucleus (STN) stimulation. BACKGROUND: Camptocormia, one of the most disabling features of @entity191 , often responds poorly to medical therapies. The reported effects of deep brain stimulation on @entity191 -associated @entity3518 vary, and preoperative characteristics affecting the surgical outcome remain unclear. METHODS: We evaluated 17 @entity1 with @entity3518 whose preoperative off-medication thoracolumbar angle exceeded 45  . We used photographs to measure their thoracolumbar angle preoperatively, 3   months after surgery, and at the last follow-up (mean 36.5   months postoperatively) in status on-medication and off-medication. The @entity1 age, duration of @entity191 and @entity3518 , daily medications, Unified @entity191 Rating Scale (UPDRS) subscores and the Schwab-England activity of daily living scale (S-E) were also recorded. Univariate analysis was performed to identify factors predictive of the postoperative improvement of @entity3518 . RESULTS: STN stimulation significantly improved the UPDRS subscores and S-E, and resulted in a reduction of daily medications 3   months post-treatment. The preoperative thoracolumbar angle (mean  SD) in status off-medication (84.0  29.5  ) was significantly ameliorated 3   months postoperatively (49.8  29.3  ) and at the last follow-up (54.8  28.3  ). There was no correlation between the postoperative @entity3518 improvement rate and preoperative parameters other than the duration and severity of @entity3518 and the @entity3034 responsiveness of the thoracolumbar angle. Symptom duration negatively affected @entity3034 responsiveness. CONCLUSIONS: STN stimulation improves @entity191 -associated @entity3518 in parallel with preoperative @entity3034 responsiveness. Long symptom duration interferes with @entity3034 responsiveness.
