Effect of a @entity1160 -supplemented enteral diet on XXXX -induced @entity1964 .

@entity1944 @entity1568 @entity1160 @entity2228 @entity7647 @entity1500 @entity35 @entity1499 @entity1964 @entity2259
Administration of an elemental diet to @entity35 given @entity1499 ( @entity1500 ), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe @entity1964 . Previous studies indicate that @entity1160 ( @entity7647 ), which is not present in elemental diets, is the preferred oxidative substrate for the gut and may facilitate intestinal recovery after injury. This study investigated the effects of a @entity1160 -supplemented elemental diet ( @entity7647 -ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of @entity1944 . Three experiments were performed. In the first experiment, @entity35 received an intragastric elemental diet supplemented with either 2% @entity7647 or an equivalent amount of @entity2228 (Control). After 4 days animals received either @entity1500 , 20 mg/kg ip, or saline ip and were killed 3 days later. The @entity7647 -ED resulted in significantly decreased weight loss, improved @entity1568 retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment @entity35 were assigned to diet as in the first experiment, but all animals received @entity1500 . Control diet animals died within 120 hrs of @entity1500 administration. The @entity7647 -ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and @entity1500 as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric @entity2259 in animals administered @entity1500 . @entity7647 -ED resulted in a significant reduction in the incidence of @entity2259 . These experiments showed that a @entity7647 -ED significantly improved nutritional status, decreased @entity1944 , decreased bacterial translocation, and resulted in improved survival in a lethal model of @entity1964 .
