Relationship between declining GFR and measures of XXXX .

@entity1 @entity943 @entity6 @entity944 @entity1009 @entity740 @entity2915 @entity4148 @entity299 @entity551 @entity6111
AIM: Cardiac and @entity4148 contributes to increased morbidity and mortality in @entity1 with @entity740 . The aim of this study was to analyze the effects of a decline in GFR on @entity551 dipping. METHODS: This cross-sectional study comprises 124 @entity1 (46 @entity1 , 78 @entity1 ; age 66  14 years) with CKD 3-5, not on renal replacement therapy. GFR was measured with @entity6111 clearance, HRV with 24-hour Holter ECG and nocturnal dipping with 24-hour ambulatory blood pressure. RESULTS: The GFR was 22.5  8.5ml/ @entity1009 .73 m(2) . The main finding was a significant curvilinear association between the 24 hour standard deviation of NN interval (24SDNN) in the HRV analysis and GFR (p=0.01), logGFR (p=0.006), @entity6 (p=0.05) and beta blocker treatment (0.03), respectively. The effect of @entity6 on 24SDNN corresponded to a decline in GFR from 30 to 12 ml/ @entity1009 .73 m(2) . There were significant curvilinear associations between systolic nocturnal dipping (p=0.02) and diastolic nocturnal dipping (p=0.05), respectively, and @entity6 but not with GFR or logGFR. CONCLUSION: In conclusion, cardiac sympathetic overdrive and decreased vagal control appear during CKD 4 and 5. The association with GFR is curvilinear. @entity6 was significantly associated with both @entity299 , as measured by heart rate variability and nocturnal blood pressure dipping, respectively. Knowing that @entity943 , often due to sympathetic @entity2915 , are an important cause of @entity944 in the dialysis population, this study contributes important knowledge on possible intervention thresholds. This article is protected by copyright. All rights reserved.
