The impact of conventional morphologic analysis on response rates and survival in @entity1 with XXXX treated initially with @entity900 -containing combination chemotherapy.

@entity1 @entity135 @entity5 @entity957 @entity900 @entity1544
The response to initial treatment with @entity900 -containing combination chemotherapy as well as survival, were correlated with @entity5 differentiation (well, moderate or poorly differentiated) in 164 @entity1 with advanced, untreated @entity957 of the @entity135 . Thirty-three percent of the @entity5 were graded as poorly differentiated, 59% moderately differentiated, and 8% were well differentiated. The overall clinical response rates were nearly equal for the three grades of differentiation: 79% for well differentiated, 86% for moderately differentiated, and 89% for poorly differentiated. The complete response rate was somewhat higher for poorly differentiated @entity5 : 46% as compared to 32% and 29% for moderately and well differentiated respectively, but the differences were not statistically significant. The median survival for each morphologic group was 22, 16, and 12 months for well differentiated, moderately differentiated and poorly differentiated @entity5 , respectively (P = 0.097). For @entity1 achieving a complete clinical response to chemotherapy, there was a difference in survival when stratified according to degree of histologic differentiation. @entity1 who were complete responders and had well or moderately differentiated @entity5 attained 75% and 38% survival at 36 months, respectively, versus 19% for @entity1 with complete response and poorly differentiated @entity5 (P = 0.064). The degree of differentiation of previously untreated @entity1544 of the @entity135 does not conclusively predict @entity5 response to combination chemotherapy, but may reflect differences in natural history. Survival is improved in @entity1 with differentiated @entity5 as compared to those with poorly differentiated @entity5 . Morphologic grading in @entity1 achieving a complete response reveals a decrease in survival for @entity1 with poorly differentiated @entity5 .
