@entity1420 level and XXXX /estradiol ratio on the day of @entity3566 administration: detrimental cutoff levels and new treatment strategy.

@entity1 @entity3566 @entity1420
OBJECTIVE: To identify if there are certain cutoff levels for P and or the P/E(2) ratio on the day of @entity3566 that would be defined as detrimental for occurrence of pregnancy in @entity1 with normal ovarian reserve undergoing cleavage-stage embryo transfer (ET). Secondarily, to determine if these same cutoffs might have the same potential negative effect in @entity1 undergoing blastocyst ET. DESIGN: Prospective cohort study including two randomized cohorts. SETTING: Private and university fertility centers. @entity1 (S): A total of 240 @entity1 undergoing long agonist protocol with at least four grade 1 day 3 embryos. INTERVENTION(S): @entity1 were randomized in a 1:1 ratio to undergo day 3 or day 5 embryo transfer. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR) was the primary outcome. RESULT(S): Using receiver operator characteristics, cutoffs for P and P/E(2) ratio were 1.5 ng/mL and 0.55, respectively. @entity1 with P  <= 1.5 ng/mL and P/E(2)  <= 0.55 undergoing cleavage-stage ET had higher CPR. Using multiple regression, P/E(2) ratio was the only independent predictor for pregnancy. The P and P/E(2) cutoffs were not correlated with CPR in blastocyst transfers. CONCLUSION(S): @entity1420 >1.5 ng/mL and P/E(2) >0.55 affect the CPR in @entity1 undergoing cleavage-stage, but not blastocyst ET. P/E(2) ratio is the only independent prognosticator for cycle outcome in @entity1 undergoing cleavage-stage ET.
