Clinical course of fetal XXXX : 40 cases.

@entity1 @entity154 @entity322 @entity2978 @entity1276 @entity16 @entity600 @entity160 @entity601 @entity2906 @entity204 @entity912
The clinical course and outcome of @entity1276 diagnosed in utero is not well understood. To approach this problem 40 cases were reviewed of intrauterine fetal @entity1276 diagnosed with sonography, and follow-up information was obtained regarding them. Sonograms were evaluated for cerebral dimensions, biparietal diameter, brain mantle size, ventricular ratio, amount of amniotic fluid, and associated abnormalities. Neonatal brain sonograms and computed tomographic (CT) scans were reviewed also. Clinical charts were reviewed for maternal age and parity, referral source, family history, fetal age at diagnosis and delivery, mode of delivery, physical examination and/or autopsy findings, karyotype, amniotic @entity160 level, cause of @entity204 , shunt placement after birth, and status of live @entity1 . The observations indicate that the prognosis for fetal @entity1276 is poor. Only six @entity1 (15%) were alive after an average follow-up of 13 months. Three @entity1 were normal and the other three had @entity16 ranging from severe ( @entity912 and @entity322 ) to minimal (2-3 months delayed motor development). Thirty-four fetuses or neonates died. Nine families elected to terminate pregnancy. Ten opted for decompression at delivery for progressive @entity1276 . @entity601 were present in 12 of 23 @entity1 at delivery. Fourteen other @entity1 had additional significant @entity154 . Other abnormal sonographic findings included @entity2978 (13 of 38), @entity2906 or decreased fluid (nine of 38), neural tube defect (nine of 40), and other @entity154 (nine of 40). These findings indicate that @entity1276 diagnosed in utero by sonography is caused by a heterogeneous group of disorders. In general, the prognosis for normal development is poor. Individual prognoses, however, depend on the specific @entity600 and the interventions used.
