a-Synuclein pathology in the cranial and spinal nerves in XXXX .

@entity1 @entity1832 @entity4775 @entity9576
UNASSIGNED: Accumulation of phosphorylated a-synuclein in neurons and glial cells is a histological hallmark of @entity1832 ( @entity1832 ) and @entity9576 ( @entity9576 ). Recently, filamentous aggregations of phosphorylated a-synuclein have been reported in the cytoplasm of Schwann cells, but not in axons, in the peripheral nervous system in @entity9576 , mainly in the cranial and spinal nerve roots. Here we conducted an immunohistochemical investigation of the cranial and spinal nerves and dorsal root ganglia of @entity1 with @entity1832 . Lewy axons were found in the oculomotor, trigeminal and @entity4775 , but not in the hypoglossal nerve. The @entity4775 were most frequently affected, with involvement in all of 20 subjects. In the spinal nerve roots, Lewy axons were found in all of the cases examined. Lewy axons in the anterior nerves were more frequent and numerous in the thoracic and sacral segments than in the cervical and lumbar segments. On the other hand, axonal lesions in the posterior spinal nerve roots appeared to increase along a cervical-to-sacral gradient. Although Schwann cell cytoplasmic inclusions were found in the spinal nerves, they were only minimal. In the dorsal root ganglia, axonal lesions were seldom evident. These findings indicate that a-synuclein pathology in the peripheral nerves is axonal-predominant in @entity1832 , whereas it is restricted to glial cells in @entity9576 .
