Association between environmental quality, stress and @entity2204 gene variation in XXXX susceptibility determination.

@entity1 @entity239 @entity2204
INTRODUCTION: @entity239 is a multifactorial disease, of which etiology is based on interaction between genetic susceptibility and environment. However, few studies attempted to identify the risk factors. OBJECTIVE: To investigate the genetic influence and its interaction with environmental quality and stress, as possible risk factors for @entity239 development. @entity1 AND METHODS: This cross-sectional study investigated two groups of @entity1 , of which 47 had a clinical diagnosis of @entity239 , and 41 @entity1 comprising thre control group, all from the town of Novo Hamburgo, RS. The @entity2204 ( @entity2204 ) gene polymorphism was analyzed in DNA extracted from total blood, in both samples. Environmental factors were studied through Lipp's Inventory of Stress Symptoms for Adults and by applying the WHOQOL-100 domain V. RESULTS: Among the @entity1 , more @entity1 had high stress levels when compared to the control sample (P < 0.001); moreover, the average scores of the WHOQOL-100 domain V, which analyze environment quality, were lower in this group (P < 0.001). @entity2204 genotypic and allelic frequencies were similar between the two groups. Multivariate analysis showed that low WHOQOL-100 scores increase the chance of disease development by 57.7 times (P < 0.001), and that high stress levels were related with the disease (OR = 197.2; P < 0.001). This approach pointed out an interaction between stress and presence of E*2 allele (P = 0.028). @entity239 was much more frequent in @entity1 with high stress levels that were E*2 non-carriers (estimated OR = 265.1), when compared to @entity1 with the same stress level, but E*2 carriers (estimated OR = 1.06). CONCLUSION: E*2 allele presence could have a protective action regarding the association between @entity239 and stress.
