XXXX with liver @entity3 and resection of the primary: Prognostic factors for decision making.

@entity1 @entity96 @entity5 @entity4056 @entity3
INTRODUCTION: @entity1 with @entity4056 present with liver @entity3 in 50-75% of cases at diagnosis. The aim of the present study was to assess prognostic factors in @entity1 with liver @entity3 from intestinal @entity5 after @entity5 surgical removal with or without liver surgery or radiofrequency ablation. The primary endpoint was disease-specific survival. METHODS: Data regarding seventy-eight consecutive @entity1 with liver @entity3 who undergone @entity5 surgical removal between 1996 and 2011 were extracted from the institutional @entity5 registry and retrospectively analyzed. RESULTS: @entity96 burden was <25% in 43 (55.1%) 25-50% in 30 (38.5%) and >50% in 5 (6.4%) @entity1 . For the whole cohort of @entity1 disease-specific survival at 3, 5 and 8 years was 93.2%, 83.6% and 77.3%, respectively. Fifteen @entity1 who underwent radical liver surgery were all alive with a median survival of 106 months (range 18-152 months). In multivariate analysis the Ki-67 index in a continuous fashion significantly correlate with prognosis (p  =  0.021). @entity96 burden (p  =  0.036) and extrahepatic involvement (p  =  0.03), were the most powerful prognosticators for @entity1 who underwent only debulking surgery. CONCLUSION: The Ki-67 index, the @entity96 burden and the presence of extrahepatic @entity3 should be carefully considered in the selection criteria for liver debulking in asymptomatic @entity1 .
