Inhaled XXXX inhibits behavioral response to airway occlusion in anesthetized @entity468 .

@entity1 @entity1353 @entity649 @entity1483 @entity4185 @entity2613 @entity5161 @entity468
BACKGROUND: A recent study showed that inhaled @entity1483 greatly improves experimentally induced @entity1353 in @entity1 . The objective of the current study is to test the hypothesis that inhaled @entity1483 suppresses the behavioral response to airway occlusion without changing the behavioral response to a somatic noxious stimulus in anesthetized animals. METHODS: In 10 spontaneously breathing @entity468 anesthetized with @entity5161 , anesthetic @entity2613 (50) was determined by measuring an end-tidal anesthetic concentration while observing escape behavior. The monitored behavior consisted of purposeful movement of the head and forearm after endotracheal tube occlusion. The duration from the start of airway occlusion to the onset of the positive response (DOCCL) was measured at the highest concentration of @entity5161 permitting the positive motor response to airway occlusion before pretreatment. @entity2613 (50) values (minimum alveolar concentration) for the suppression of a somatic motor response to a noxious stimulus induced by toe pinch (toe-pinch @entity2613 (50)) were also determined. Then, the effects of inhaled @entity1483 or vehicle on the @entity2613 (50) for the suppression of the behavioral response to airway occlusion, DOCCL, and toe-pinch @entity2613 (50) were evaluated in a randomized, cross-over design. RESULTS: The @entity2613 (50) for the suppression of the behavioral response to airway occlusion significantly decreased (P < 0.01) and DOCCL was significantly prolonged (P < 0.01) after @entity1483 inhalation, whereas @entity4185 did not change these measurements. The decrease in @entity2613 (50) for the suppression of the behavioral response to airway occlusion after @entity1483 inhalation lasted 3 h. @entity1483 inhalation did not affect the toe-pinch @entity2613 (50). CONCLUSION: Inhaled @entity1483 suppressed the behavioral response to airway occlusion in anesthetized animals without affecting the response to somatic noxious stimulus. The authors' animal model of @entity649 may be applicable to the study of @entity1353 in regard to its mechanism and treatment.
