Plasma level of the endogenous @entity1372 pump ligand marinobufagenin is related to the salt-sensitivity in XXXX .

@entity1 @entity7584 @entity1219 @entity1372 @entity36454 @entity35
OBJECTIVE:: Salt-induced elevation of the endogenous digitalis like @entity1372 pump ligand @entity36454 ( @entity7584 ) in the Dahl salt-sensitive @entity35 resulted in elevated blood pressure (BP). Here, we tested, in @entity1 , whether @entity7584 levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in @entity7584 and any salt-induced change in @entity7584 is related to salt sensitivity. METHODS:: Thirty-nine healthy individuals (53  11 years old; 20 @entity1 and 19 @entity1 ) had a total daily @entity1219 intake of 50mmol (low-salt) and 150mmol (high-salt) for 4 weeks each, in a random order. ABP and @entity7584 in plasma and urine were measured at baseline (unstandardized salt intake) and after high and low-salt intake. RESULTS:: At baseline, plasma @entity7584 (P- @entity7584 ) was related to 24-h SBP (r=0.43, P=0.007) and DBP (r=0.32, P=0.047), whereas 24-h urinary excretion of @entity7584 (UE- @entity7584 ) was related to 24-h DBP only (r=0.42, P=0.008). Sex-specific analyses revealed that these relationships were significant in @entity1 only. Compared with low-salt, high-salt diet increased P- @entity7584 (P=0.029), mainly driven by results in @entity1 . Male P- @entity7584 responders vs. nonresponders (above vs. below median of high-salt induced P- @entity7584 increase) had markedly enhanced SBP (10.4  6.4 vs. 1.0  6.0mmHg; P=0.003) and DBP (6.7  5.0 vs. -0.6  3.6mmHg; P=0.001) salt sensitivity. CONCLUSION:: In @entity1 , @entity7584 increases with 24-h ABP, and similar to Dahl salt-sensitive @entity35 , 4 weeks of high-salt induced @entity7584 response is accompanied by marked salt sensitivity. However, these patterns seem to be sex-specific and are not observed in @entity1 .
