@entity859 -stress dynamic real-time myocardial perfusion CT and XXXX -stress first-pass dual-energy myocardial perfusion CT for the assessment of acute @entity662 : initial results.

@entity662 @entity1 @entity296 @entity859
PURPOSE: Recent innovations in CT enable the evolution from mere morphologic imaging to dynamic and functional testing. We describe our initial experience performing myocardial stress perfusion CT in a clinical population with acute @entity662 . METHODS AND MATERIALS: Myocardial stress perfusion CT was performed on twenty consecutive @entity1 (15 @entity1 , 5 @entity1 ; mean age 65    8 years) who presented with acute @entity662 and were clinically referred for stress/rest SPECT and cardiac MRI. Prior to CT each @entity1 was randomly assigned either to Group A or to Group B in a consecutive order (10 @entity1 per group). Group A underwent @entity859 -stress dynamic real-time myocardial perfusion CT using a novel "shuttle" mode on a 2nd generation dual-source CT. Group B underwent @entity859 -stress first-pass dual-energy myocardial perfusion CT using the same CT scanner in dual-energy mode. Two experienced observers visually analyzed all CT perfusion studies. CT findings were compared with MRI and SPECT. RESULTS: In Group A 149/170 @entity296 (88%) could be evaluated. Real-time perfusion CT (versus SPECT) had 86% (84%) sensitivity, 98% (92%) specificity, 94% (88%) positive predictive value, and 96% (92%) negative predictive value in comparison with perfusion MRI for the detection of myocardial perfusion defects. In Group B all @entity296 were available for analysis. Compared with MRI, dual-energy myocardial perfusion CT (versus SPECT) had 93% (94%) sensitivity, 99% (98%) specificity, 92% (88%) positive predictive value, and 96% (94%) negative predictive value for detecting hypoperfused @entity296 . CONCLUSION: Our results suggest the clinical feasibility of myocardial perfusion CT imaging in @entity1 with acute @entity662 . Compared to MRI and SPECT both, dynamic real-time perfusion CT and first-pass dual-energy perfusion CT showed good agreement for the detection of myocardial perfusion defects.
