Regional blood flows during induced @entity551 produced by XXXX or @entity13673 in the rhesus monkey.

@entity99 @entity1508 @entity26 @entity1854 @entity13673 @entity3810 @entity551
In monkeys anesthetized with 70% @entity3810 and 0.5% inspired @entity1508 in @entity26 , we measured changes in systemic hemodynamics and regional blood flows produced by @entity1854 and @entity13673 . Regional blood flow measurements were made using the radioactive microsphere technique. Control measurements were made before infusion of @entity1854 and @entity13673 into each animal in sequence in amounts adequate to reduce mean arterial pressure to approximately 55 +/- 5 mm Hg. Measurements were made during each drug infusion after a stable period of @entity551 lasting at least 30 min. During @entity1854 infusion, cerebral blood flow remained unchanged, but myocardial blood flow increased significantly. However, pressure-rate product, an indirect measure of myocardial @entity26 consumption, was unchanged, implying that myocardial blood flow exceeded myocardial @entity26 requirement. During @entity13673 infusion, cerebral blood flow decreased, although cerebral metabolic rate for @entity26 was unchanged due to increased @entity26 extraction by the brain. @entity13673 also produced a decrease in myocardial blood flow that was in proportion to the decrease in myocardial @entity26 requirement as indicated by pressure-rate product. Neither drug produced changes in @entity99 . We conclude that brain @entity26 reserve is decreased during @entity551 induced by @entity13673 . Blood flows to other organs are not significantly impaired in monkeys during @entity551 to a mean arterial pressure of approximately 55 mm Hg induced by either @entity1854 or @entity13673 .
