Pharmacokinetics of @entity21562 in normal and Pasteurella-infected XXXX .

@entity12196 @entity4186 @entity21562 @entity22157
1. Disposition kinetics of @entity21562 were studied in @entity12196 @entity22157 following intravenous and/or intramuscular injection in a single dose of 30 mg/kg body weight. In addition, the tissue distribution and residual pattern of the drug were determined in diseased @entity4186 . 2. The maximum serum concentration of @entity21562 in control healthy and infected @entity4186 was reached 1 hour after intramuscular injection but the peak concentration in control @entity4186 was higher than in infected birds. 3. The volume of distribution, total body clearance and systemic bioavailability were higher in infected @entity4186 than in control birds 5.15 l/kg, 10.24 ml/kg/min and 73.03% respectively. Data relating to intravenous injection were analysed using a 2 compartment open model curve fit. 4. @entity21562 was not detected in the serum of infected @entity4186 on the 7th day following intramuscular administration of 30 mg/kg body weight twice daily for 5 successive days but was detected in kidney, bile and liver.
