The effects of XXXX and @entity1522 on @entity5 and host DNA synthesis.

@entity1522 @entity137 @entity5 @entity367 @entity35 @entity413 @entity8856
@entity5 -bearing animals provided with intravenous @entity413 and @entity1522 ( @entity8856 ) exhibit enhanced response to S-phase-specific chemotherapeutic agents (H. M. Reynolds, J. M. Daly, B. Rowlands, S. J. Dudrick, and E. M. Copeland. Cancer 45: 3069, 1980; M. H. Torosian, J. L. Mullen, E. E. Miller, et al. J. Parenter. Enteral Nutr. 7: 337, 1983). To determine the mechanism of this response, DNA synthesis rate during starvation or a 48-hr infusion of @entity413 / @entity1522 ( @entity367 /AA) was evaluated in @entity5 , liver, and terminal ileal cells of 68 @entity35 . @entity5 cells exhibited a rapid increase in DNA synthesis following the initiation of an infusion of @entity367 /AA. This increase was most marked after 2 hr of infusion and returned to control levels within 24 hr. Liver DNA synthesis rate increased in both starved and @entity367 /AA animals over 48 hr with a larger increase in animals receiving @entity367 /AA. Ileal DNA synthesis decreased equally in both groups. Short pulse @entity367 /AA produced transient increases in @entity5 DNA synthesis. Changes in host tissues occurred but followed a different temporal sequence. This may indicate the existence of a period of time following initiation of metabolic manipulation when @entity5 susceptibility to phase-specific chemotherapeutic agents will be enhanced while host tissues will be spared from increased @entity137 .
