Adhesion molecules in cutaneous XXXX .

@entity1 @entity483 @entity32 @entity1569 @entity5 @entity4105 @entity8729 @entity5658 @entity272 @entity67182 @entity73264
As in other organs, leukocyte adhesion molecules and their ligands play a major role in cutaneous inflammatory events both by directing leukocyte trafficking and by their effects on antigen presentation. Skin biopsies of inflamed skin from @entity1 with diseases such as as @entity1569 or @entity483 reveal up-regulation of endothelial cell expression of @entity73264 , @entity67182 . Studies of evolving lesions following UVB irradiation, Mantoux reaction or application of contact allergen, demonstrate that expression of these adhesion molecules parallels leukocyte infiltration into skin. When cutaneous @entity32 is widespread (e.g. in @entity5658 ), soluble forms of these molecules are detectable in serum. In vitro studies predict that peptide mediators are important regulatory factors for endothelial adhesion molecules. Intradermal injection of the cytokines interleukin 1, @entity5 necrosis factor alpha and interferon gamma into normal @entity1 skin leads to induction of endothelial adhesion molecules with concomitant infiltration of leukocytes. In addition, neuropeptides rapidly induce @entity8729 translocation to the cell membrane and expression of @entity4105 . Adhesion molecules also play a crucial role as accessory molecules in the presentation of antigen to T lymphocytes by Langerhans' cells. Expression of selectin ligands by Langerhans' cells is up-regulated by various inflammatory stimuli, suggesting that adhesion molecules may be important in Langerhans' cell migration. The skin, because of its accessibility, is an ideal organ in which to study expression of adhesion molecules and their relationship to inflammatory events. Inflammatory @entity272 are common and inhibition of lymphocyte accumulation in skin is likely to prove of great therapeutic benefit.
