Expressions of the CIP/KIP family of CDK inhibitor proteins in primary intestinal large XXXX : correlation with clinical outcomes.

@entity1 @entity5438 @entity706 @entity876 @entity1892 @entity982 @entity8755 @entity994
Immunohistochemistry was performed for @entity994 , @entity5438 , @entity8755 and @entity876 on @entity982 -embedded tissue sections from 25 @entity1 who had surgically resected @entity706 . It was then correlated with the @entity1 ' clinical course in an attempt to determine the expression patterns and clinical significance of the CIP/KIP family of cyclin-dependent kinase inhibitors in primary intestinal large @entity1892 . @entity994 immunostaining was positive in 11 cases (44%) and @entity5438 was positive in 8 cases (32%). All cases were @entity8755 -negative. @entity876 immunostaining was positive in 14 cases (56%) and negative in 11 cases (44%). With respect to the relationship between @entity994 and @entity876 , seven cases were @entity876 +/ @entity994 -, seven cases were @entity876 +/ @entity994 +, seven cases were @entity876 -/p2l-, and four cases were @entity876 -/ @entity994 +. The expression patterns of @entity994 and @entity876 did not influence the @entity1 's clinical outcome. However, @entity5438 -positive cases had a much higher percentage of @entity1 sustaining a continuous complete remission state (8/8, 100%) as compared to @entity5438 -negative cases (10/17, 59%), although this difference was not statistically significant (p = 0.057). These results suggest that @entity5438 immunoreactivity may be associated with a better clinical outcome. However, further study with larger series are planned to determine the clinical significance of @entity5438 overexpression in primary intestinal large @entity1892 .
