Clinical significance of angiogenic factor expression at the deepest invasive site of advanced XXXX .

@entity1 @entity7 @entity5 @entity9961 @entity1015 @entity2101 @entity14 @entity3 @entity2280
@entity5 angiogenesis is a complicated process for which the mechanisms remain unclear. The aim of this study was to elucidate the clinical significance of several angiogenic factor expression as a predictor of the invasive/metastatic potential and of the prognosis of advanced @entity14 ( @entity14 ) in relation to their intratumoral histologic heterogeneity. One hundred fifty two @entity1 who had undergone surgical resection for advanced @entity14 entered this study. @entity1015 , @entity7 , and @entity9961 were examined immunohistochemically with antibodies 1C6-203, A-20, and C-20, respectively. @entity5 @entity2101 ( @entity2101 ) was determined immunohistochemically with anti- @entity2280 antibody. Expression of @entity1015 , of @entity7 , and of @entity9961 at the deepest invasive site were detected in 77 (50.7%), 62 (30.8%), and 71 (46.7%) of the 152 lesions, respectively. @entity1015 , @entity7 , and @entity9961 expression at the deepest invasive site in lesions with liver @entity3 (77, 67, and 70%) was significantly higher than that in those without liver @entity3 (44, 34, and 41%). In cases with curative surgery, @entity1 with @entity1015 , @entity7 , and @entity9961 expression at the deepest invasive site had a significantly poorer prognosis than those without @entity1015 , @entity7 , and @entity9961 expression at the deepest invasive site. @entity1015 , @entity7 , and @entity9961 expression at the deepest invasive site correlated significantly with @entity2101 . Multivariate analysis with logistic regression for 5-year survival in @entity1 with curative surgery showed that lymph node @entity3 and @entity7 expression were significant risk factors. Expression of @entity1015 , @entity7 , and @entity9961 was correlated significantly with metastatic potential and prognosis in relation to @entity2101 . Of the several angiogenic factors, @entity7 expression at the deepest invasive site of @entity5 was the most statistically significant indicator of prognosis in advanced @entity14 .
