Spinal anesthesia for cesarean delivery. A comparison of two doses of hyperbaric XXXX .

@entity1 @entity1341 @entity413
BACKGROUND AND OBJECTIVES: Hyperbaric local anesthetic pools in the thoracic spinal curvature in supine @entity1 . The authors hypothesized that @entity1 receiving 12 or 15 mg of hyperbaric @entity1341 would achieve similar levels of sensory block but the spinal anesthetic would be denser and longer lasting in @entity1 receiving the 15 mg dose. METHODS: Twenty eight healthy term parturients scheduled for elective cesarean delivery randomly received 12 or 15 mg hyperbaric 0.75% @entity1341 in 8.25% @entity413 . @entity1 were in the right lateral position during drug injection and were then positioned supine with left uterine displacement on a horizontal operating table. A blinded anesthesiologist assessed the dermatome level of sensory analgesia to pinprick every 2 minutes for 20 minutes, then every 15 minutes until the sensory level regressed to T10. RESULTS: The mean level of sensory anesthesia was 2.2 spinal segments higher in @entity1 receiving 15 mg versus 12 mg hyperbaric @entity1341 (24.8 +/- 3.7 versus 22.6 +/- 1.4 spinal segments; P = .031). Regression to T10 occurred more quickly in the 12 mg than in the 15 mg group (140.0 +/- 16.5 versus 162.1 +/- 33.8 minutes, P = .046). @entity1 height did not correlate with the maximum number of spinal segments blocked in either group. All @entity1 had adequate surgical anesthesia. CONCLUSIONS: Parturients receiving 15 mg of hyperbaric @entity1341 developed a higher mean level and longer duration of sensory analgesia than those receiving 12 mg.
