Ecological effects of XXXX prophylaxis in orthognatic surgery.

@entity1 @entity868 @entity114 @entity37933 @entity281 @entity3397 @entity11121 @entity86 @entity375
A study was conducted to evaluate 2 prophylactic @entity114 regimens in 18 @entity1 undergoing orthognathic surgery. The effects on the oral microflora were also studied. All @entity1 received 3 g @entity37933 - @entity114 as infusion from the beginning of operation and then 3 g every 6th hour during 24 h. One group of 9 @entity1 then received 1 g @entity11121 as oral suspension twice daily for 6 days postoperatively. The second group of 9 @entity1 received no further @entity114 . One @entity281 occurred in this second group, but the @entity1 was cured with @entity868 . 7 of the 9 @entity1 who received @entity114 for 1 week, showed pronounced decreases in the number of streptococci and micrococci. In the 9 other @entity1 who received only @entity3397 for one day, much smaller changes in the aerobic microflora were observed. Colonization with different enterococci, enterobacteria or @entity375 was greater in the group receiving 1-week treatment. No major differences between the 2 groups of @entity1 , concerning the impact on the anaerobic microflora were observed. The results indicate that @entity3397 is still a suitable prophylactic antibiotic in maxillofacial surgery. Extension of the antibiotic coverage to 1 week is doubtful because of the increased ecological risks. The clinical significance of anaerobes was obvious, as one @entity86 occurred caused by an anaerobic micro-organism.
