Relationship between lipoprotein levels and in vivo insulin action in normal young white XXXX .

@entity1 @entity301 @entity1674 @entity3190 @entity413 @entity165
In epidemiologic studies, @entity3190 has been found to be an independent risk factor for @entity301 ( @entity301 ). However, the mechanisms responsible for its role in atherogenesis remain unclear. We studied the relationship of in vivo insulin action and plasma lipids and lipoproteins in 44 normotriglyceridemic white @entity1 (aged 18 to 34 years). The euglycemic, hyperinsulinemic @entity413 clamp technique was used to quantitate insulin-mediated @entity413 disposal (M/I value) at a plasma insulin concentration of approximately 100 microU/mL. The M/I value correlated negatively with plasma @entity1674 (r = -0.553, P less than .0001), as well as with fasting plasma insulin levels (r = -0.483, P less than .001), independent of age, body mass index, and fasting plasma @entity413 levels. A negative correlation of the M/I value was also observed with very low density lipoprotein (VLDL)- @entity165 (r = -0.347, P less than .05), VLDL- @entity1674 (r = -0.474, P less than 0.005), and total @entity165 /high density lipoprotein (HDL)- @entity165 ratio (r = -0.431, P less than .01). The relationship between the M/I value and the total @entity165 /HDL- @entity165 ratio was independent of VLDL- @entity165 and VLDL- @entity1674 , however, not independent of plasma @entity1674 . No relationship was observed between insulin-mediated @entity413 uptake and total @entity165 , low density lipoprotein (LDL)- @entity165 , and HDL- @entity165 values. Individual differences in plasma @entity1674 , fasting insulin concentration, and the total @entity165 /HDL- @entity165 ratio accounted for about half the variance observed in the M/I value.(ABSTRACT TRUNCATED AT 250 WORDS)
