Comparison of @entity1338 , local anesthetics, and placebo for XXXX reduction in pediatric tonsillectomy.

@entity1 @entity773 @entity1341 @entity3303 @entity158 @entity1338
OBJECTIVE: To determine if pretonsillectomy injection of local anesthetics with and without @entity1338 reduces @entity158 following tonsillectomy in @entity1 . DESIGN: A prospective, randomized, double-blind, placebo-controlled trial. SETTING: Tertiary care academic medical center. @entity1 : A total of 120 @entity1 , ages 3 to 17 years, presenting for tonsillectomy. INTERVENTIONS: @entity1 were randomized to 1 of 3 pretonsillectomy injection groups: (1) saline, (2) @entity3303 plus @entity1341 , or (3) @entity3303 plus @entity1341 plus @entity1338 . MAIN OUTCOME MEASURES: The total number of analgesic doses consumed on postoperative days (PODs) 1, 3, 5, and 7. Secondary outcome variables included total time and intravenous analgesic doses required in the recovery room, visual analog scale @entity158 scores, and maximum tolerated diet on postoperative days 1, 3, 5, and 7. RESULTS: The total number of analgesic doses on PODs 1, 3, 5, and 7 were not significantly different between the randomization groups (P = .53). The median numbers (interquartile ranges) of analgesic doses were 12.0 (9.0-16.8) for the @entity3303 plus @entity1341 plus @entity1338 group, 12.0 (10.0-16.5) for the @entity3303 plus @entity1341 group, and 14.0 (9.0-15) for the placebo group. The placebo group was found to have a more advanced diet on @entity773 (P = .04) and significantly less @entity158 on POD 3 (P = .02). Multivariable analysis showed @entity1 in the @entity3303 plus @entity1341 plus @entity1338 group were significantly less likely to need @entity158 medication in the recovery room compared with @entity1 in the placebo group and again showed that the placebo group achieved a significantly more advanced diet and had less @entity158 on @entity773 . CONCLUSION: Pretonsillectomy injection of @entity3303 , 1%, and @entity1341 , 0.5%, with or without @entity1338 (25  g) is not recommended for the @entity158 . TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00678379.
