Bioassay of XXXX for Possible Carcinogenicity (CAS No. 87-29-6).

@entity788 @entity19 @entity5 @entity3981 @entity1358 @entity72318 @entity35 @entity157 @entity652 @entity420
A bioassay of @entity72318 (a synthetic flavoring agent) for possible carcinogenicity was conducted by administering the test chemical in feed to F344 @entity35 and B6C3F1 @entity19 . Groups of 50 @entity35 and 50 @entity19 of each sex were fed the test chemical in diets containing 15,000 or 30,000 ppm for 103 weeks and then observed for an additional 2 or 3 weeks. Controls consisted of groups of 50 untreated @entity35 and 50 untreated @entity19 of each sex. All surviving animals were killed and necropsied at 105 to 107 weeks. Mean body weights of the dosed male and female @entity35 and @entity19 were lower than those of the corresponding controls throughout the bioassay, and weight decrements were dose related. Mortality in @entity35 and @entity19 of either sex was not affected by administration of the test chemical. In male @entity35 , @entity420 or @entity1358 or @entity652 of the pancreas were found in low incidences in dosed @entity35 but not in control @entity35 . In direct comparisons with matched control groups, the incidences of these @entity5 were not significantly increased; however, because these @entity5 rarely occur spontaneously in aging F344 @entity35 , they were considered to be related to compound administration. Similar @entity788 have not been detected among 634 historical-control male F344 @entity35 at the same laboratory. In the female @entity35 , no @entity5 occurred at incidences that could be clearly related to the administration of the test chemical. In both male and female @entity19 , the @entity157 or @entity652 were dose related (P<0.001) and significant (P</= 0.001) in direct comparisons of dosed and control groups. It was concluded that under the conditions of this bioassay @entity72318 was carcinogenic for male and female B6C3F1 @entity19 , inducing @entity157 or @entity652 . The test chemical was also carcinogenic for male F344 @entity35 , inducing low incidences of @entity3981 or @entity652 of the pancreas and @entity420 or @entity652 of the renal cortex. @entity72318 was not carcinogenic for female F344 @entity35 . Levels of Evidence of Carcinogenicity: Male @entity35 : Positive Female @entity35 : Negative Male @entity19 : Positive Female @entity19 : Positive
