Use of proteins as biomarkers and their role in XXXX .

@entity1 @entity650 @entity12848 @entity172 @entity320 @entity0 @entity13063 @entity5344 @entity5 @entity72014 @entity2041 @entity105 @entity6400 @entity204
SUMMARY: Improved diagnostic methods and medical therapies are necessary for early detection and treatment and an improved prognosis. It is thus vital to both examine and evaluate the role of the various existing proteins as biomarkers in @entity105 and to assess the contribution of these proteins in anti- @entity5 activity, for consideration in therapeutic strategies. It is essential to both examine and evaluate the role of the various existing proteins as biomarkers in @entity105 and to assess the contribution of these proteins in anti- @entity5 activity, for consideration in therapeutic strategies. The purpose of this review is twofold. Firstly, it is to evaluate recent data about which proteins can be utilized as biomarkers in @entity105 . The proteins reviewed include: @entity72014 , @entity650 , CCN, and S100. Secondly, it is to evaluate the contribution of dietary proteins in @entity5 activity. Specifically, how whey protein, soy proteins and lectin, a phytochemical could be useful in @entity5 prevention and treatment. RECENT FINDINGS: Whey protein, present in dairy products, is an excellent source of the sulphur amino acid cysteine, the rate limiting substrate in @entity2041 synthesis. Notably, this protein survives digestion and has been shown to have anti-carcinogenic properties in animal studies. Lectins are phytochemicals present in plant foods, and have active components which alters @entity5 initiation, promotion and progression. Lectins have been characterized as a useful tool in biochemistry, cell biology, immunology and in diagnostic and therapeutic purposes in @entity5 research. Soy proteins contain various compounds, including @entity6400 , protease inhibitors and protein kinase inhibitors, which have been proven effective in @entity5 growth inhibition. They have therefore, been greatly emphasized in @entity5 prevention and treatment. It has been proved that soy food consumption was associated with decreased risk of @entity204 and recurrence of @entity0 . @entity72014 is a recently discovered protein whose main role is to transport C1P, a pro-inflammatory molecule. The discovery of @entity72014 may shine a light on the mechanism of inflammatory diseases, and hopefully offer a potential target for therapeutic purposes in @entity5 research. @entity650 is a multifunctional cytokine that affects the activity of @entity5 cells. It is involved in @entity5 growth, and elevated levels is associated with an increased risk of @entity5 . S100B is a well-established biomarker for @entity320 , and useful in assessing @entity5 load, stage and prognosis for @entity1 with this disease. Other members of this family of proteins include @entity12848 , which has been associated with several @entity5 and @entity13063 , which has been found to be decreased in some @entity5 . CCN are a group of regulatory proteins, located in the extracellular matrix (maricellular). They are involved in cellular adhesion, mitogenesis, chemotaxis, cell survival, and wound healing. CCN proteins are also able to modulate the signals of several proteins, which may also influence skeletal development and angiogenesis. Many of the functions of these proteins are thus also related to @entity5 growth. Furthermore, CCN interacts with @entity172 in the development of @entity5 , and is implicated in some @entity5344 .
