XXXX of the ovary with functioning stroma and virilization in pregnancy: a case report and review of the literature.

@entity43 @entity1 @entity5473 @entity1420 @entity2931 @entity5 @entity147 @entity8940 @entity2277 @entity342 @entity9296 @entity8665
Virilization caused by @entity43 with functioning stroma during pregnancy is extremely rare and has been reported in many @entity43 . In @entity8940 with maternal virilization during pregnancy the stromal cells responsible for the hormone secretion resemble @entity8665 or Leydig cells and have been referred to as luteinized stromal cells. We present a case of a 30-year-old, gravida 2, para 1, @entity1 who presented at approximately the 38th week of pregnancy with features of virilization. At the same time, a cesarean section was performed because of @entity147 and a male weighing 3,030 g without any gross abnormalities was delivered. A large @entity5 of the right ovary was detected and a right salpingo-oophorectomy was performed. Histopathologically, the @entity5 proved to be a benign mucinous @entity9296 . Masses typically resembling lutein stromal cells or Leydig cells of the testes or ovarian hilus were found in the wall of the cyst below the mucinous epithelium. No crystalloids of Reinke were identified. The stromal component of the @entity5 was characterized as functioning stroma with luteinized stromal cells. The glandular mucinous epithelium showed focal positivity for @entity1 chorionic gonadotrophin. The cytoplasm of the luteinized stromal cells reacted strongly and diffusely with antiserum for @entity2277 . Also, the cytoplasm of the luteinized stromal cells showed focal intense positivity for @entity5473 , and focal mild positivity for @entity1 chorionic gonadotrophin. Staining results for @entity2931 and @entity1420 receptors were negative. In conclusion, we present an unusual case of clinical virilization during pregnancy associated with an @entity43 with functioning stroma. The virilizing manifestations disappeared after removal of the @entity43 , supporting the perception that the functioning ovarian stroma was responsible for the @entity342 production.
