Prediction of dietary XXXX consumption from fasting plasma concentration or urinary excretion.

@entity1 @entity3091 @entity15605 @entity6 @entity4213 @entity58010 @entity3095 @entity523 @entity3092 @entity3096
OBJECTIVES: to predict @entity4213 content of the habitual diets of free-living subjects from urine and plasma concentrations of @entity4213 . DESIGN: Ten type 2 @entity6 @entity1 (five male, five female), mean age 60 (s.e.m. 7) y and BMI 30.2 (s.e.m. 3.5) kg/m2 were treated in a random crossover design for a 2 week period on either a low @entity3096 diet or on the same diet supplemented at one of two high @entity4213 levels (total 77.3 or 110.4 mg/day) provided by supplements of 1500 ml tea daily and 400 g fried white onion in olive oil with and without @entity523 ketchup and herbs. SETTING: Glasgow Royal Infirmary, University of Glasgow, Scotland. MAIN OUTCOME MEASURES: Fasting plasma concentration, urine concentration and 24 h excretion of @entity3092 , @entity58010 , @entity15605 and @entity3091 . RESULTS: Plasma @entity3095 concentration (r=0.750, P=0.001), 24 h urine concentration (r=0.847, P=0.001) and 24 h urine excretion (r=0.728, P=<0.001) were all highly significantly related to dietary intake and gave similar estimates of intakes. Fasting plasma @entity4213 concentrations on habitual diets ranged from 0 to 43.7 ng/ml mean. Regression equations were constricted: total @entity4213 intake r=0.74, P<0.001 and @entity3092 intake r=0.744, P<0. 001. From these equations, @entity3095 intakes from habitual diets were estimated at 17-50, mean 35 mg/day. Of this, 91% was from @entity3092 . CONCLUSIONS: Dietary @entity4213 are absorbed and appear in plasma and urine as potential biomarkers in concentrations related quantitatively to intake. Estimation of dietary intake from plasma or urine concentrations appears possible. SPONSORSHIP: Rank Prize Funds and Rank Foundation of the Department of @entity1 Nutrition; Ministry of Health and Medical Education, IR Iran. European Journal of Clinical Nutrition (2000) 54, 143-149
