Primary extranodal non-Hodgkin's XXXX of the oral region: analysis of 11 autopsy cases.

@entity1 @entity706 @entity1778 @entity3 @entity1893 @entity204
The authors describe autopsy cases of primary extranodal @entity1893 of the oral regions in 11 (8%) of 134 @entity1 : 10 were clinical stage IE, and one was IIE. Histologic subtypes of each @entity706 included the diffuse large cell type (8 cases), diffuse mixed type (2 cases) and Burkitt's type (1 case) according to the @entity706 Study Group (JLSG) classification. All patients received anti-lymphomatous chemotherapy and/or radiotherapy. Nine cases had active disease, 3/9 manifesting @entity1778 . Nodes were involved. There was involvement of cervical lymph nodes in 7 (64%). Viscera most commonly involved were, in order of decreasing frequency: lung, kidney, pancreas, liver, spleen, heart, gastrointestinal tract, bone marrow, and adrenal gland. It is apparent that primary extranodal @entity1893 of the oral region arise in a single focus, and extensions of the disease are not random. The primary lesions spread to regional lymph nodes by way of lymphatic channels, and to extranodal organs of the intrathoracic and intraabdominal regions by contiguous direct invasion of adjacent organs and by blood-borne @entity3 . Wide spread dissemination at the time of @entity204 was found in 6 cases and 3 modes of spreading were observed.
