Selective intestinal decontamination with @entity2887 for the prevention of early XXXX after liver transplantation.

@entity1 @entity2348 @entity281 @entity2887 @entity6884 @entity166
The role of selective intestinal decontamination with @entity2887 (FQ- @entity6884 ) in the prevention of early @entity2348 (EBIs) in liver transplant recipients (LTRs) is unknown. We used the online database of the Spanish Network of Infection in Transplantation/Spanish Network for Research in @entity166 , which prospectively analyzed 1010 LTRs from 12 Spanish hospitals from September 2003 to February 2005. We compared the incidence and etiology of EBIs (30 days after transplantation) in 415 LTRs from 4 centers that used FQ- @entity6884 (>7 days) and in 595 LTRs from 8 hospitals that did not use FQ- @entity6884 . A multivariate logistic regression analysis (including an adjustment for the transplant center factor) was performed to evaluate the potential protective factor of FQ- @entity6884 in the development of EBIs. We reported 266 EBI episodes in 252 LTRs (incidence = 24.9%). There were no differences in the incidence of EBIs between @entity1 in the FQ- @entity6884 group and @entity1 not in the FQ- @entity6884 group [109/415 (26.3%) versus 143/595 (24%), P = 0.9]. Although LTRs who received FQ- @entity6884 had a lower incidence of @entity281 due to enteric bacteria (2.7% versus 6.5%, P = 0.007) and a higher incidence of @entity281 due to nonfermenting gram-negative bacilli (6.6% versus 2.6%, P = 0.004), these findings could not be confirmed after an adjustment by the center factor in the multivariate models. We found no significant differences in the incidence of @entity281 (3.4% with FQ- @entity6884 versus 3.9% without FQ- @entity6884 , P = 0.5). Multivariate analysis did not confirm any protective effect of FQ- @entity6884 against the development of EBIs by enteric bacteria. In conclusion, FQ- @entity6884 does not reduce the incidence of EBIs in LTRs and could be withheld from this group of @entity1 .
