Rapid appearance of new cerebral microbleeds after acute XXXX .

@entity1 @entity64 @entity6249 @entity1188 @entity10334 @entity385
BACKGROUND: It is unknown whether the development of cerebral microbleeds (MBs), small areas of signal loss on T2*-weighted gradient-echo imaging (GRE), follows a slow or a rapid process. We hypothesized that MBs may develop rapidly after certain critical events, such as @entity64 , and investigated the frequency, location, and factors associated with the formation of new MBs after acute @entity385 . METHODS: We retrospectively examined 237 consecutive acute @entity385 @entity1 who underwent MRI within 24 hours and follow-up MRI during the week after symptom onset. We defined new MBs as MBs that newly appeared on follow-up GRE outside the infarcted area. We examined the association of new MBs with demographics, risk factors, laboratory data, baseline @entity6249 ( @entity6249 ; @entity10334 and @entity1188 ). RESULTS: Seventy-five @entity1 (31.6%) had baseline MBs, and 30 (12.7%) developed new MBs. Multiple logistic regression analysis indicated that the presence of baseline MBs (odds ratio [OR] 5.72, 95% confidence interval [CI] 2.12-15.42, p = 0.001) and severe @entity6249 (OR 2.94, 95% CI 1.12-7.77, p = 0.03) independently predicted the development of new MBs. Of the 56 new MBs, 29 (51.8%) appeared in the lobar location, 17 (30.4%) appeared in the deep location, and 10 (17.9%) appeared in the infratentorial location. CONCLUSIONS: This study suggests that new microbleeds (MBs) can develop rapidly after acute @entity385 . Baseline @entity6249 are predictors for the development of new MBs. Further studies will be needed to investigate the clinical implications and mechanisms of these findings.
