Effects of @entity1732 , XXXX and @entity900 treatment on Leydig cell structure and transcription of steroidogenic enzymes in @entity35 testis.

@entity1 @entity12962 @entity251 @entity71790 @entity71789 @entity1373 @entity900 @entity2879 @entity15090 @entity24097 @entity1732 @entity31018 @entity35 @entity18946 @entity7816 @entity165
UNASSIGNED: Cytotoxic anticancer chemotherapy affects pituitary-testicular hormonal axis in @entity1 and in animals. This study investigated the effects on Leydig cells of three cycles of @entity1732 , @entity2879 and @entity900 (0.75, 7.5, and 1.5mg/kg, respectively; @entity12962 ) chemotherapy in @entity35 testis. The chemotherapy has induced @entity1373 of and degenerative changes in Leydig cells at the end of @entity12962 exposure, which remained so even after a recovery time of 63 days. The increased testicular oxidative stress at the end of the chemotherapy returned to normal level after the recovery time. The chemotherapy has stimulated the transcription of @entity15090 ( @entity15090 ), @entity24097 ( @entity24097 ), cytochrome P450 @entity165 side-chain cleavage ( @entity7816 ), @entity31018 , and inhibited that of 17b-hydroxysteroid dehydrogenase ( @entity71789 ) and @entity18946 in association with increased @entity165 and decreased @entity251 levels. Even after the recovery time, the chemotherapy still had inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and @entity71790 , but not on the @entity24097 gene. The @entity165 and @entity251 levels also did not show any significant differences with the control group. The decreased @entity251 level at the end of chemotherapy was probably due to inhibition of @entity71790 and @entity71789 genes. In conclusion, clinically relevant dose-levels and treatment protocols of @entity12962 chemotherapy adversely affect Leydig cell function. The @entity12962 chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels.
