Clinical study on treatment of chronic viral XXXX with chishaodanpi decoction.

@entity1 @entity1087 @entity6571 @entity910 @entity425 @entity1448 @entity158 @entity623
OBJECTIVE: To observe the therapeutic effect of Chishaodanpi decoction (CSDPD) on chronic viral @entity1448 . METHODS: A total of 107 subjects with chronic viral @entity1448 were enrolled in our hospital from March 2007 to November 2012. @entity1 were randomly divided into treatment (54 cases) and control groups (53 cases). The control group was treated with potassium magnesium aspartate, diammonium glycyrrhizinate, glucurolactone, vitamin C, and lamivudine, once a day. The treatment group was treated with modified CSDPD, 100 mL a time, twice a day, in addition to the treatment given to the control group. The @entity1 in both groups were treated for 8 weeks. The main symptoms and signs were recorded every day throughout the clinical trial. Before and after the trial, changes in liver function including total bilirubin (TBil), direct bilirubin (DBil), total bile acid (TBA), and the activities of @entity623 ( @entity623 ), alanine aminotransferase (ALT), @entity6571 ( @entity6571 ), and y-glutamyl transferase (y-GT), were all detected. Adverse reactions were also recorded. RESULTS: There were no differences in gender, age, disease duration, symptoms, signs, or laboratory findings between the two groups (P > 0.05). After an 8-week treatment, improvements in @entity1087 , @entity425 , poor appetite, abdominal distention, and skin itching were significantly better in the treatment group than in the control group (P < 0.05). In the treatment group, 43 @entity1 had a significant response to the treatment, seven @entity1 had a response, and four @entity1 had no response, with 21, 12, and 20 @entity1 in the control group, respectively. The total effective rate was 92.6% in the treatment group and 62.3% in the control group, which was a significant difference (P < 0.05). The levels of TBil, DBil, TBA, @entity623 , ALT, @entity6571 , and y-GT in both groups were significantly lower after treatment, and were significantly different between the two groups (P < 0.05). A few @entity1 in the treatment group had mild adverse effects such as @entity910 frequency and mild @entity158 . No other adverse reactions were observed in either group.
