Diagnostic significance of @entity20591 in XXXX .

@entity1 @entity5 @entity20591 @entity3 @entity356
As one of the most common @entity5 , @entity356 still lacks @entity5 markers with enough specificity and sensitivity. Therefore the development of novel @entity5 markers is necessary for early diagnosis in clinics. MicroRNA (miR) has been known to be of unique expressional patterns in various @entity5 and may work as potential @entity5 markers for clinical use. This study thus explored the significance of plasma @entity20591 in clinical diagnosis of @entity356 and its effects on proliferation of @entity5 cells. Plasma @entity20591 levels were quantified by real-time quantitative fluorescent PCR methods in 80 cases of @entity356 @entity1 and healthy individuals to analyze the correlation between @entity20591 and clinical features. @entity20591 inhibitor was further transfected into @entity1 @entity356 cells for further cell proliferation using CCK-8 approach. @entity20591 was significantly up-regulated in @entity356 @entity1 plasma samples compared to healthy individuals (P<0.01). The area under ROC curve was 0.895 (95% CI: 0.846~0.943). It has a specificity of 93.8% and a sensitivity of 77.5% in diagnosing @entity356 . @entity20591 level was also correlated with @entity5 differentiation stage, lymph node @entity3 , TNM stage and @entity5 size (P<0.05). The down-regulation of @entity20591 in @entity356 cells inhibited cell proliferation (P<0.05). @entity20591 was significantly up-regulated in @entity356 @entity1 and can facilitate the in vitro proliferation of @entity5 cells. It may work as a biological marker for @entity356 .
