Brachial-ankle pulse wave velocity and rate of renal function decline and mortality in XXXX .

@entity1 @entity101 @entity740 @entity1391 @entity204
BACKGROUND AND OBJECTIVES: Increased arterial stiffness was reported to be associated with decreased estimated GFR (eGFR). Previous studies suggested that arterial stiffness might play a role in renal function progression in @entity1 with @entity740 ( @entity740 ). The aim of this study was to investigate whether there was an independent association between brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and renal function progression in @entity740 @entity1 . DESIGN, SETTING, @entity1 , _ MEASUREMENTS: This longitudinal study enrolled 145 @entity1 with @entity740 stages 3 to 5. The baPWV was measured by using an ABI-form device. The change in renal function was estimated by eGFR slope. The study endpoints were defined as commencement of dialysis or @entity204 . RESULTS: After a stepwise multivariate analysis, the eGFR slope was positively associated with baseline eGFR and negatively associated with @entity101 and baPWV (b=-0.165, P=0.033). Seventeen @entity1 entering dialysis, and eight deaths were recorded. Multivariate forward Cox regression analysis identified that higher baPWV (hazard ratio, 1.001; P=0.001), lower baseline eGFR, and higher serum @entity1391 level were independently associated with progression to commencement of dialysis or @entity204 . CONCLUSIONS: Our results show an independent association between baPWV and renal function decline and progression to commencement of dialysis or @entity204 in @entity1 with @entity740 . Screening @entity740 @entity1 by means of baPWV may help identify a high-risk group of rapid renal function decline and progression to commencing dialysis or @entity204 .
