[ XXXX and NF-kB in prostatic disease: relation with @entity5 ].

@entity1 @entity9135 @entity1069 @entity2451 @entity263 @entity310 @entity5 @entity1486
INTRODUCTION: NF-kB ( @entity2451 / @entity9135 ) is a transcription factor involved in @entity310 -induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB ( @entity2451 and @entity9135 ) with serum levels of @entity1486 (PSA), both in normal males and in those with pathologic conditions of the prostate. MATERIALS AND METHODS: this study was carried out in 5 normal, 24 @entity1069 ( @entity1069 ) and 19 @entity1 with @entity263 ( @entity263 ). Immunohistochemical and Western blot analyses were performed on tissue and serum PSA was assayed by PSA DPC Immulite assays (Diagnostics Products Corporation, Los Angeles, CA). RESULTS: in controls, @entity9135 NF-kB was not found and @entity2451 was scantly detected in 60% normal samples in the cytoplasm of epithelial cells. Both @entity2451 and @entity9135 were expressed in 62.5% of the samples with @entity1069 and in 63.2% of those with @entity263 . Both increased its frequency of expression with higher PSA serum levels. CONCLUSIONS: Activation of NF-kB revealed by its nuclear translocation in @entity263 could be related to @entity5 progression and elevated seric PSA levels. A better understanding of the biologic mechanism by which circulating PSA levels increase and its relation with NF-kB expression is needed. Possibly, NF-kB blockage could be used as a therapeutic target to counteract proliferation in @entity263 .
