The influences of casein phosphopeptides on metabolism of ectopic bone induced by decalcified bone matrix implantation in XXXX .

@entity35 @entity730 @entity460
The effect of casein phosphopeptides (CPP) on bone metabolism was studied in the ectopic bone induced by the implantation of decalcified bone matrix in @entity35 . Forty-two @entity35 male @entity35 of 7 weeks old were fed low @entity460 diets (0.39% of @entity460 ) with or without supplying 0.50% of CPP, or a control diet (0.91% of @entity460 ) without CPP supplementation. After a 1-week preliminary period, each @entity35 was subcutaneously implanted with 30 mg of demineralized bone matrix powder. Fourteen and 21 days after the implantation, the implants were harvested from 7 @entity35 of each group. @entity460 content in the graft was not significantly different among all groups on day 14. Subsequently, the content of @entity460 rapidly increased in the grafts irrespective of diets given. However, the graft of the CPP- group contained less @entity460 than the other groups and the @entity460 content was more in the control @entity35 compared to the CPP+ animals on day 21. Alkaline phosphatase activity (an index of bone and cartilage @entity730 ) was lower in the control group than in the CPP+ group on day 14. The enzyme activity subsequently decreased in the control group but the activity was not changed in the other groups. As a result, the activity of alkaline phosphatase was lower in the control animals than in the other @entity35 on day 21. Tartrate-resistant cap phosphatase activity (an index of bone resorption) was higher in the CPP--group compared to the control on day 14. On day 21, the activity was higher in the CPP--group compared to the others.(ABSTRACT TRUNCATED AT 250 WORDS)
