Subfertility and prepregnancy overweight/ XXXX : possible interaction between these risk factors in the etiology of @entity8 .

@entity1 @entity249 @entity8 @entity6 @entity28 @entity600
BACKGROUND: Maternal @entity249 and high body mass index (BMI) are both associated with adverse reproductive outcomes, including some @entity600 . One study reported an association between @entity249 and @entity8 (Li, 1999). METHODS: We defined @entity249 as the mother's report that she sought fertility treatment from a doctor/clinic, and high BMI as a prepregnancy BMI > or = 25. We included 169 @entity1 with @entity8 ( @entity8 [n = 41], obstructive defects [n = 117], and duplication defects [n = 11]) and 2763 @entity1 without defects who were born in 1968-1980 in metropolitan Atlanta, after excluding mothers who reported @entity6 . Conditional logistic regression (matching variables: race, birth hospital, and birth period) was used to obtain effect estimates (adjusted for maternal age and gestational age). RESULTS: Subfertility was more common among case-mothers (11.8%) than control-mothers (7.8%), high BMI was similar among case-mothers (11.2%) and control-mothers (10.9%), and joint exposure ( @entity249 and high BMI) was reported by 3% case-mothers and 0.7% of control-mothers. Joint exposure to @entity249 and high BMI was associated with @entity8 (odds ratio [OR] = 5.8; 95% confidence interval [CI] = 2.0-16.3). All case-mothers who reported a joint exposure had @entity1 with @entity8 (OR = 8.5; 95% CI = 2.9-24.7). There was no association observed for either exposure alone ( @entity249 and low BMI, or high BMI and no @entity249 ) for either all @entity8 or obstructive defects. CONCLUSIONS: @entity1 who are overweight/ @entity28 and experience @entity249 may be more likely to have an @entity1 with an @entity8 . Further exploration of possible biologic mechanisms is needed.
