Antitussive activity and other related pharmacological properties of XXXX (AT-17).

@entity137 @entity19 @entity235 @entity840 @entity468 @entity29541 @entity2473 @entity109 @entity112 @entity70772 @entity10425
Antitussive activity and some other related pharmacological properties of @entity70772 were studied. Toxic symptoms in @entity19 and @entity235 were due to the CNS excitation. Acute @entity137 of (AT-17) in @entity19 was slightly (s.c.) or far (p.o.) weaker than that of @entity10425 , but it was three times as toxic as @entity10425 in @entity235 (i.v.). Antitussive efficacy was about 40% of that of @entity10425 in @entity235 , whereas 77% as potent as @entity10425 in @entity468 . It showed no relaxing effect on the bronchial muscle of @entity840 in either normal tone or @entity112 -induced @entity2473 . It had analgesic effect 1/3 as potent as @entity10425 in @entity19 but it was not antagonized by @entity29541 . The prolongation of hexobarbital sleeping time by AT-17 was similar extent to that by @entity10425 . Anti-electroshock effect was half as potent as that of @entity109 . The inhibitory effect on the transportation of intestinal contents in @entity19 was far weaker than that of @entity10425 . Effect on the respiratory and circulatory systems were also investigated.
