Comparison of fasting and postprandial plasma lipoproteins in subjects with and without XXXX .

@entity1 @entity301 @entity1674 @entity412 @entity165
Plasma lipoprotein levels, including remnant-like particle (RLP) @entity165 and RLP @entity1674 , were assessed in fasting (12 hours) and postprandial (PP) (4 hours after a fat-rich meal) states in 88 @entity1 with @entity301 ( @entity301 ) and 88 controls. All lipoproteins were assessed by direct methods. We hypothesized that @entity1 with @entity301 would have greater percent increases in their @entity412 levels, RLP @entity165 , and RLP @entity1674 , in response to a fat-rich meal. In the fasting state, @entity1674 , RLP @entity165 , RLP @entity1674 , and low-density lipoprotein (LDL) @entity165 levels were all significantly higher in cases versus controls by 51%, 35%, 39%, and 40%, respectively. These levels were 57%, 37%, 64%, and 37% higher in the PP state, respectively. Mean high-density lipoprotein (HDL) @entity165 values were 27% lower in cases in both the fasting and PP states. After eating, @entity1674 , RLP @entity165 , and RLP @entity1674 increased 64%, 71%, and 290% in controls, respectively, whereas in cases these levels increased by 71%, 94%, and 340%, respectively (all p <0.0001). Percent increases in the PP state were not significantly different in cases versus controls. Following the fat-rich meal, LDL and HDL @entity165 decreased by 5% and 4% in controls, and by 7% and 6% in @entity1 , with no significant difference in percent changes between groups. Fasting values correlated very highly with PP values for all parameters (all p <0.0001). Our data indicate that although @entity1 with @entity301 have higher fasting and PP levels of @entity1674 , RLP @entity165 , and RLP @entity1674 than controls, the response (percent increase) to a fat-rich meal is comparable in both groups. Thus, a feeding challenge is not essential for assessment of these lipoproteins. Moreover, it is not necessary to obtain a fasting sample to assess direct LDL and HDL @entity165 .
