Dysregulated @entity1414 and @entity28622 , XXXX , @entity50835 in Disc Degeneration Revealed by Bioinformatics Methods.

@entity1 @entity50835 @entity1643 @entity1414 @entity1797 @entity28622 @entity65723
STUDY DESIGN: Bioinformatics analysis of published microarray data. OBJECTIVE: This study aimed to reveal the possible genes and pathways related to the pathogenesis of @entity1797 by analyzing the microarray data. SUMMARY OF BACKGROUND DATA: @entity1797 ( @entity1797 ) is one of the main causes of @entity1643 , which has become an enormous economic burden for society. METHODS: Gene expression data of annulus cells and nucleus pulposus cells from @entity1797 @entity1 and controls subjects were downloaded from Gene Expression Omnibus. T-test and enrichment analysis were used to identify differentially expressed genes (DEGs) and DEGs-associated functions and pathways in @entity1797 respectively. Protein-protein interaction network and module were constructed to analyze the key nodes associated with this disease. RESULTS: Totally 326 DEGs and 35 DEGs were obtained from the annulus cells and nucleus pulposus cells, respectively. The DEGs of @entity1797 in annulus cells were mainly involved in translation, cell adhesion, cell death regulation and skeletal system development whilst the DEGs in nucleus pulposus cells were mainly related to the biological processes of vascular system development, skeletal system development and enzyme-linked receptor protein signaling pathway. @entity1414 was the common DEGs in both annulus cells and nucleus pulposus cells. The ribosomal proteins ( @entity28622 , @entity65723 and @entity50835 ) in module were enriched in biological processes of translation, translation elongation and RNA processing. CONCLUSION: The results revealed the involvement of @entity1414 in skeletal system process and @entity28622 , @entity65723 and @entity50835 in the protein synthesis processes in the progression of @entity1797 , suggesting their potential use in the diagnosis and therapy of @entity1797 .
