Clinical, biological, and microbiological pattern associated with XXXX : a retrospective longitudinal study.

@entity1 @entity281 @entity2841 @entity413
BACKGROUND: Our aim was to describe the pattern of @entity281 ( @entity281 ) development using a dynamic approach. STUDY DESIGN: Retrospective longitudinal study. METHODS: We analyzed the files of 449 neurosurgical @entity1 who underwent placement of external ventricular drain (EVD). During the study period, @entity2841 sampling was performed on a daily base setting. @entity281 was defined as a positive @entity2841 culture resulting in antibiotic treatment. For @entity281 @entity1 , we arbitrary defined day 0 (D0) as the day antibiotic treatment was started. In these @entity1 , we compared dynamic changes in clinical and biological parameters at four pre-determined time points: (D-4, D-3, D-2, D-1) with those of D0. For all @entity2841 -positive cultures, we compared @entity2841 biochemical markers' evolution pattern between @entity281 @entity1 and the others, considered as a control cohort. RESULTS: Thirty-two suffered from @entity281 . Peripheral white blood cell count did not differ between D-4-D0. Median body temperature, @entity2841 cell count, median Glasgow Coma Scale, @entity2841 protein, and @entity413 concentrations were significantly different between D-4, D-3, D-2, and D0. At D0, 100  % of @entity2841 samples yielded organisms in culture. The physician caring for the @entity1 decided to treat @entity281 based upon positive @entity2841 culture in only 28  % (9/32) of cases. In the control cohort, @entity2841 markers' profile trends to normalize, while it worsens in the @entity281 @entity1 . CONCLUSIONS: We showed that clinical symptoms and biological abnormalities of @entity281 evolved over time. Our data suggest that @entity281 decision to treat relies upon a bundle of evidence, including dynamic changes in @entity2841 laboratory exams combined with microbiological analysis.
