The use of anti-IgE in the treatment of XXXX .

@entity1 @entity2023 @entity565 @entity56 @entity230 @entity288
Allergic sensitization plays a significant role in the development of @entity565 in many @entity1 . IgE-mediated immune responses play a central role in the pathogenesis of this condition. The development of a treatment that interrupts this pathway is particularly desirable to prevent downstream events. Large-scale trials in @entity1 ranging in age from 6 to 76 years have shown that omalizumab therapy is safe and effective in the treatment of severe @entity56 . This is particularly true in @entity1 who experience poor disease control despite high doses of inhaled @entity230 or need oral @entity230 for control of their disease. These @entity1 are at risk for severe exacerbations despite recommended therapy, and anti-IgE therapy has proved to reduce these episodes. Early aggressive therapy of @entity565 is needed for maximum control in all age groups. Despite the efficacy of inhaled @entity230 there is a reluctance to use these agents, especially in younger @entity1 . Because of these concerns a long-acting treatment is especially desirable. Because of imperfect effort or technique limiting inhaled medications, introduction of an effective agent that could be administered parenterally at long intervals also is very important. @entity2023 is a co-existing problem in many @entity1 with @entity56 . Immunotherapy trials have suggested that early intervention with immunotherapy and @entity2023 @entity1 may actually prevent the development of @entity565 . Early treatment of patients with anti-IgE may also have benefits, particularly in those who have concomitant @entity2023 in addition to @entity56 . Although omalizumab has not yet received Food and Drug Administration approval in the United States, it shows great promise in the management of @entity1 requiring high doses of inhaled or oral corticosteroids for control of their disease and to prevent exacerbations of @entity565 in such @entity1 . Reductions in high doses of inhaled or oral @entity288 may prevent long-term complications of these treatments.
