XXXX and first-episode @entity161 -spectrum disorders. The Danish OPUS trial.

@entity1 @entity161 @entity734
AIM: To evaluate whether integrated treatment (given by OPUS), in comparison with standard treatment, significantly reduced the number of @entity1 with @entity734 and improved clinical and social outcome in the group of substance abusers after 2 years. METHODS: A total of 547 @entity1 with first-episode @entity161 -spectrum disorders were included in the study, 275 randomly assigned to OPUS treatment and 272 to standard treatment. OPUS treatment consisted of assertive community treatment with family involvement and social skills training. Standard treatment offered contact with a community mental health centre. Main outcome measure was reduction in comorbid @entity734 . RESULTS: At 2-year follow up, 42 (17.3%) @entity1 from OPUS and 40 (20.7%) @entity1 from standard treatment met criteria for @entity734 (odds ratio=0.5, 95% confidence interval 0.3-1.0). OPUS treatment compared with standard treatment significantly reduced negative and disorganized symptoms in the substance abuser group. @entity1 with @entity734 in the OPUS treatment spent significantly fewer days in hospital during the 2-year period than @entity1 given standard treatment (109 days vs. 167 days) and adhered to treatment significantly more often. CONCLUSIONS: Results from this trial indicate that integrated treatment given by OPUS reduced @entity734 and improved clinical outcome in the substance abuser group. Supplementing the OPUS treatment with therapeutic programmes for @entity1 with a comorbid @entity734 would probably further improve outcome.
