Abnormalities of chromosome band 11q23 and the @entity11626 gene in pediatric myelomonocytic and monoblastic XXXX . Identification of the t(9;11) as an indicator of long survival.

@entity1 @entity11626 @entity1778 @entity149
PURPOSE AND METHODS: We reviewed the cytogenetic pattern of the malignant cells in 36 @entity1 who were < 20 years of age and who had M4 and @entity1778 , excluding M4Eo cases with inv(16). We performed fluorescence in situ hybridization (FISH) and molecular studies to determine the actual incidence of 11q23/ @entity11626 abnormalities in these @entity1 . RESULTS: Eighteen @entity1 had 11q23 translocations or insertions detected by cytogenetic analysis (15 cases) or by FISH (3 cases); 10 @entity1 had t(9;11), all of whom had M5a. Eight @entity1 had other 11q23 translocations or insertions not involving chromosome 9[t(11q23)] (four each had @entity1778 ). Eighteen cases with M4/M5 did not have 11q23 abnormalities. @entity11626 rearrangements were found in all @entity1 with translocations or insertions of 11q23 who were studied. Clinically, @entity1 with t(9;11) were indistinguishable from other @entity1 with @entity1778 . In contrast, the t(11q23) group was characterized by extreme hyperleukocytosis, @entity149 , and skin involvement. @entity1 with the t(9;11) had a better outcome when compared with @entity1 in the t(11q23) group (EFS +/- SE at 3 years, 56 +/- 17% versus 10 +/- 10%, p = 0.04), and to all the remaining @entity1 with @entity1778 (p = 0.04). CONCLUSIONS: The combination of cytogenetic, FISH, and molecular analysis provides a highly sensitive strategy for detection of 11q23/ @entity11626 gene rearrangements in childhood @entity1778 . Our more precise classification of these @entity1 allows a more accurate correlation with outcome. The favorable prognostic significance of the t(9;11) should be confirmed in prospective studies including a larger number of @entity1 as well as adults.
