Nonrandom chromosome structural aberrations and oncogene loci in XXXX @entity320 .

@entity1 @entity5 @entity320
Short-term cultures of 10 malignant @entity320 derived from 8 @entity1 were analyzed cytogenetically. The chromosome composition of the @entity5 was found to be similar in terms of modal number and structural and numerical aberrations, especially the nonrandom nature of breakpoints. Six chromosomes were consistently involved in marker formation. Aberrations of chromosomes #1 and #9 were identified in every @entity5 , whereas structural alterations of chromosome #2 were found in 9 @entity5 . In contrast, aberrations of chromosomes #6, #3, and #7 were identified in 7, 7, and 8 of the @entity5 , respectively. The nonrandom breakpoints on these chromosomes frequently coincided with known oncogenic loci and resulted in morphologically identical marker chromosomes. Consecutive lesions were obtained for two @entity1 . Common markers were identified in both cases, indicating the clonal origin of the @entity5 . In addition, many marker chromosomes characteristic of the individual lesions were also identified. The presence of these lesion-specific markers indicates the nonrandom selective nature of the metastatic process and suggests the possible heterogeneity of the original @entity5 cell population.
