The association of ankle-brachial index with silent XXXX : results of the Atahualpa Project.

@entity1 @entity64 @entity3657 @entity6249 @entity301 @entity1188 @entity62 @entity65
BACKGROUND: An abnormal ankle-brachial index has been associated with @entity64 and @entity301 , but little is known about its relationship with silent @entity6249 . AIM: To assess the value of ankle-brachial index as a predictor of silent small vessel disease in an Ecuadorian geriatric population. METHODS: @entity64 -free Atahualpa residents aged >= 60 years were identified during a door-to-door survey. Ankle-brachial index determinations and brain magnetic resonance imaging were performed in consented @entity1 . Ankle-brachial index  <=0  9 and >= 1  4 were proxies of @entity3657 and noncompressible arteries, respectively. Using logistic regression models adjusted for age, gender, and @entity65 status, we evaluated the association between abnormal ankle-brachial index with silent @entity1188 , @entity62 , and cerebral microbleeds. RESULTS: Mean age of the 224 @entity1 was 70        8 years, 60% were @entity1 , and 80% had poor @entity65 status. Ankle-brachial index was  <=0  90 in 37 @entity1 and >= 1  4 in 17. Magnetic resonance imaging showed @entity1188 in 27 cases, moderate-to-severe @entity62 in 47, and cerebral microbleeds in 26. Adjusted models showed association of @entity1188 with ankle-brachial index    <=   0  90 (OR: 3  72, 95% CI: 1  35-10  27, P   =   0  01) and with ankle-brachial index   >=    1  4 (OR: 3  85, 95% CI: 1  06-14  03, P   =   0  04). @entity62 were associated with ankle-brachial index    <=   0  90 (P   =   0  03) and ankle-brachial index   >=    1  4 (P   =   0  02) in univariate analyses. There was no association between ankle-brachial index groups and cerebral microbleeds. CONCLUSIONS: In this population-based study conducted in rural Ecuador, apparently healthy individuals aged >= 60 years with ankle-brachial index values  <=0  90 and >= 1  4 are almost four times more likely to have a silent @entity1188 . Ankle-brachial index screening might allow recognition of asymptomatic @entity1 who need further investigation and preventive therapy.
