Heterogeneous expression of XXXX gene product in noninvasive @entity0 .

@entity1 @entity1137 @entity3821 @entity0 @entity18962 @entity189
BACKGROUND: The two major types of noninvasive @entity0 , @entity3821 ( @entity3821 ) and @entity1137 ( @entity1137 ), are quite different in their histopathologic appearance and clinical implications. @entity1137 is only a marker of an increased risk of later development of @entity189 , whereas most @entity3821 lesions are at least nonobligate precursors of @entity189 . @entity3821 is a heterogeneous group of lesions composed of several distinct subtypes, with only the comedo subtype having immediate malignant potential. The authors' purpose was to analyze noninvasive @entity189 for the presence of a gene product ( @entity18962 ) indicative of a favorable prognosis in @entity189 to determine differences (1) among the different types of CIS and (2) in CIS with and without an accompanying invasive component. METHODS: Immunohistochemical methods were used to detect @entity18962 gene product in archival material from two groups of @entity1 : Group 1 consisted of 54 cases of purely noninvasive @entity189 , and Group 2 consisted of 55 examples of noninvasive @entity189 associated with an invasive component. RESULTS: Among the cases of CIS with no invasion, @entity1137 and comedo @entity3821 expressed more @entity18962 than noncomedo @entity3821 (P < or = 0.03). There were no differences among these CIS subtypes in the group with invasion. Comparing subtypes of CIS in the groups with or without invasion, only comedo @entity3821 was significantly different, with greater expression in the CIS group with no invasion compared with comedo @entity3821 associated with an invasive component (P = 0.04). CONCLUSIONS: These results support the special nature of @entity1137 and the heterogeneous nature of @entity3821 . The in situ component attending an invasive component may be different from anatomically similar lesion without associated invasion. The absence of @entity18962 in comedo @entity3821 may be indicative of invasive capacity.
