Correlation between @entity393 and scala media area in XXXX with long-standing @entity5570 .

@entity1 @entity5570 @entity4 @entity840 @entity1442 @entity1274 @entity393
HYPOTHESIS: Histologic analysis of the hydropic and normal @entity840 cochleae was undertaken to assess a potential correlation between the magnitude of @entity5570 and @entity393 . It was hypothesized that a greater correlation than previously reported might be found by looking at long-standing @entity5570 and high-frequency range hearing. BACKGROUND: Surgically induced @entity5570 in @entity840 is the most widely used animal model for the study of @entity1 M  ni  re's Disease and recapitulates both @entity5570 and progressive @entity1274 . A strong correlation between the magnitude of @entity4 and severity of @entity393 has been reported in the @entity1 condition, but not in the animal model. METHODS: Nine albino @entity840 were each subjected to surgical obstruction of the endolymphatic sac and duct of the right ear. The left ears remained as internal histologic controls. Hearing was assessed from 2 kHz to 32 kHz by auditory brain stem response testing for 16 to 25 weeks after surgery. Histologic morphometry after the animals were killed was used to quantify both turn-specific and weighted overall @entity4 . These measures were correlated with @entity393 in each animal at all tested frequencies. RESULTS: A statistically significant correlation between the magnitude of @entity4 and the severity of @entity393 was observed for 2 kHz and 16 kHz. These frequencies correlated with both turn-specific @entity4 and overall @entity4 . However, turn-specific @entity4 did not reliably correlate with the magnitude of @entity393 at anatomically appropriate frequency ranges. Where such a correlation did exist, it might well have been simply part of an expression of an overall correlation between @entity4 and @entity393 . CONCLUSIONS: There may be a greater correlation between @entity4 and @entity393 in @entity840 with long-standing surgically induced @entity4 than has previously been reported in animals with @entity1442 . These findings help to validate continued use of the model for @entity393 related to M  ni  re's Disease, verify the rationale of treatment modalities aimed at reducing @entity4 in the @entity1 condition, and may indicate that efforts at reducing @entity4 in such @entity1 has benefits toward long-term hearing preservation.
