Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to XXXX in @entity1 with and without cervical @entity75 .

@entity1 @entity43376 @entity310 @entity5 @entity1083 @entity75 @entity15646 @entity43377 @entity8923 @entity1082 @entity2784
BACKGROUND: The @entity1082 ) predisposes 500   000 @entity1 to @entity5 . Host genetic background may facilitate virus persistence in the uterine cervix. Polymorphisms in regulatory and coding regions of cytokine genes have been associated with susceptibility to some @entity1 diseases. AIM: This study aims at investigating whether @entity310 @entity15646 and @entity8923 @entity43377 and @entity43376 polymorphisms are associated with susceptibility to @entity1083 /progression to @entity2784 ( @entity2784 ). SUBJECTS AND METHODS: One hundred and twenty-two HPV infected and 132 HPV negative @entity1 (the latter used as healthy controls) were analysed. @entity310 @entity15646 and @entity8923 ( @entity43377 and @entity43376 ) polymorphisms were analysed using specific sequence polymorphism PCR (SSP-PCR). Univariate statistical analysis and a logistic regression were performed. RESULTS: The @entity310 -308A allele was associated with susceptibility to @entity1083 (p   =   0.0008), while the @entity8923 -607A allele conferred protection against @entity1083 (p   =   0.0043). @entity310 @entity15646 and @entity8923 ( @entity43377 and @entity43376 ) polymorphisms were not associated with development of @entity75 (p   >   0.05). An association was also observed between smoking and susceptibility to the development of @entity2784 . CONCLUSION: The findings suggest an association between two @entity310 SNPs and susceptibility to @entity1083 in @entity1 from Northeast Brazil. The results need to be functionally validated and replicated in other populations with different ethnic backgrounds.
