Combination XXXX and @entity750 treatment after simulated childbirth injury improves stress @entity322 .

@entity322 @entity3815 @entity750 @entity112 @entity35
AIMS: @entity112 and @entity750 -related pharmaceuticals have the potential to modulate micturition and continence. The aim of this study was to determine if treatment with @entity112 and/or @entity750 improves stress @entity322 (SUI) in female @entity35 . METHODS: Twenty-six age-matched female @entity35 underwent @entity3815 (PNC   +   VD), to produce SUI. One week after injury, @entity35 were treated subcutaneously with saline, @entity112 (1.1    g), @entity750 (2 g), or the combination of both twice daily for another week. A sham injured group received sham PNC   +   VD and were treated with saline (n   =   7). Leak point pressure (LPP) testing with simultaneous external urethral sphincter (EUS) electromyography (EMG) was conducted 2 weeks after injury. The urethra was harvested for qualitative and quantitative histology. Data were analyzed with a one-way ANOVA and Student-Newman-Keuls posthoc test with P   <   0.05 indicating statistically significant differences between groups. RESULTS: Combination treatment significantly increased LPP after PNC   +   VD compared to injured sham treatment and treatment with either @entity112 or @entity750 alone. Compared to injured sham treated @entity35 , all three treatments significantly increased EUS EMG amplitude at both baseline and peak pressure and EUS EMG firing rate at peak pressure during LPP testing. There were more consistent urethral striated muscle fibers and thicker smooth and striated muscle with combination and @entity112 treatment. There was a statistically significant shift to a greater proportion of thicker collagen fibers in the urethra in @entity750 and combination treated @entity35 compared with injured sham treated @entity35 . CONCLUSIONS: Combination treatment was the most effective and may provide an effective therapy for SUI. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.
