Effects of brain irradiation and chemotherapy on myelosuppression in XXXX .

@entity1 @entity295 @entity3 @entity151 @entity204 @entity166
The effect of brain irradiation on myelosuppression was studied in @entity1 with @entity151 ( @entity151 ) by comparing 24 @entity1 who received brain irradiation for brain @entity3 at presentation (irradiated @entity1 ) with 24 control @entity1 who were selected by matching ages and non-CNS metastatic sites with those of irradiated @entity1 . All @entity1 were evaluated during the first three courses of chemotherapy. More irradiated @entity1 than control @entity1 had chemotherapy dose reductions from the starting dose level for the second (nine of 22 v two of 24; P = .03) and the third (nine of 18 v three of 20; P = .05) courses of chemotherapy. Overall, more irradiated @entity1 had chemotherapy dose reductions than did control @entity1 (11 of 22 v three of 24; P = .01). The difference was highly significant even after other variables were considered in a multivariate analysis (P less than .001). Myelosuppression was more severe in irradiated @entity1 for WBCs (P = .01) and for platelets (P = .05). When the second course of chemotherapy was administered at the same dose levels as in the first course, irradiated @entity1 had greater decreases in nadir counts after the second course compared with the first course than did control @entity1 . Irradiated @entity1 had a higher incidence of @entity166 than did control @entity1 (14 of 24 v six of 24; P = .02), particularly after the second course of chemotherapy (seven of 22 v one of 24; P = .04). There were four treatment-related @entity204 due to @entity295 in irradiated @entity1 . Following brain irradiation given concurrently with intensive chemotherapy, close monitoring of myelosuppression and adjustments of chemotherapy doses are advised.
