Detection of fetal growth restriction in XXXX with chronic @entity101 : is it feasible?

@entity1 @entity101 @entity6 @entity1592 @entity1468 @entity2241
OBJECTIVE: To determine the utility of sonographic estimated fetal weight (EFW) in diagnosing @entity1592 ( @entity1592 , birth weight < 10% for gestational age) in @entity1 with chronic @entity101 . METHODS: All pregnant @entity1 with @entity101 delivered during a 5-year period at three centers were identified retrospectively. @entity1 with gestational @entity101 , @entity1468 , @entity6 , @entity2241 and absence of a sonographic examination within 3 weeks of delivery were excluded. Likelihood ratio (LR) and guidelines established by the Evidence-Based Medicine Working Group were used to determine whether sonographic EFW is a reliable diagnostic test to detect @entity1592 . RESULTS: At the three centers, there were 264 @entity1 with chronic @entity101 (122, 77 and 65 at centers I, II and III, respectively). The incidence of @entity1592 ranged from 13% to 27% but was similar at the three locations (p = 0.064). The LR (with 95% confidence interval (CI)) of detecting @entity1592 was 4.4 (95% CI 2.5, 7.7), 2.3 (95% CI 1.4, 3.7) and 6.1 (95% CI 2.7, 13.7) at centers I, II and III, respectively. Based on the proportions of abnormal growth, we required 253 and 71 newborns with fetal growth restriction at centers I and II, respectively, to have narrow confidence intervals around the clinically important LR of 10. The extremely low incidence of @entity1592 at center III (13%) precluded the estimation of required sample size. CONCLUSION: Use of Evidence-Based Medicine Working Group guidelines indicates that sonographic EFW is slightly to moderately useful in detecting fetal growth restriction in @entity1 with chronic @entity101 .
