The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with XXXX .

@entity1 @entity1468 @entity7939
PROBLEM: To determine the understudied relationship between complement Bb during pregnancy in subjects with @entity1468 compared with normotensive controls. METHOD OF STUDY: Nested case-control study. RESULTS: Average Bb levels significantly decreased over time in pregnancy [ @entity7939 (S.E.): -0.0094 (0.0005), P < 0.01]. Cross-sectionally, at less than 10 weeks, Bb levels decreased with increasing gestational age in @entity1 who remained normotensive [ @entity7939 (S.E.): -0.007 (0.02) and for @entity1 who developed @entity1468 ( @entity7939 (S.E.): -0.059 (0.03) P = 0.12]. Among @entity1 who developed @entity1468 , Bb levels were greatest when samples were drawn in the gestational window of 15-20 weeks [( @entity7939 (S.E.): 0.06 (0.02)], while levels among normotensive @entity1 were inversely related with gestational age [ @entity7939 (S.E.): -0.02 (0.01)]. The differences in slopes between cases and controls between 10 and 21 weeks' gestation were statistically significant (P = 0.003). CONCLUSIONS: We suggest dysregulation of Bb activation between 10 and 20 weeks' gestation in @entity1 who develop @entity1468 .
