Parenteral antibiotics and selective intestinal decontamination do not prevent enteric XXXX or translocation observed in a @entity1707 model of small bowel transplantation.

@entity1707 @entity1944 @entity7048 @entity2176 @entity2890 @entity870 @entity205 @entity5274 @entity6124 @entity8701
Alterations in the luminal microflora and increased intestinal translocation have been reported to occur following experimental and clinical small bowel transplantation (SBT). @entity1944 ( @entity1944 ) has been used to prevent luminal overgrowth and bacterial translocation. Despite the wide use of @entity1944 in clinical SBT, there are no data supporting its usefulness in this situation. Thus, the aim of this investigation was to examine the effects of @entity205 (CsA) and @entity1944 upon @entity6124 and translocation in a @entity1707 model of SBT. Nineteen Large White female @entity1707 weighing 30 +/- 2 kg underwent a total orthotopic SBT and were randomly allocated to one of the following experimental groups as follows: Group 1 (No. 8) @entity870 25 mg/kg body weight (b.w.)/day administered subcutaneously and @entity7048 2 g/day im. Group 2 (No. 6) received the identical immunosuppression but the @entity7048 2 g/day im was discontinued on the 5th Postoperative Day (pod) and switched to a @entity1944 regimen consisting of @entity2176 , 1 g, @entity8701 , 500,000 IU, Colistin, 1,500,000 IU, and @entity2890 , 100 mg, given through a @entity5274 . Group 3 (No. 5) received no immunosuppression but antibiotic consisting of @entity7048 2 g im/day. Group 4 (No. 7) underwent a small bowel autotransplantation. Group 4 received @entity1944 as in group 2 but no immunosuppression was given. Finally, 17 normal animals were sham-operated and were used as normal controls (N group). The animals in groups 1, 2, and 4 were sacrificed on the 29th pod. Those in group 3 were sacrificed on the 7th pod.(ABSTRACT TRUNCATED AT 250 WORDS)
