Fibroblast growth factors and their receptors in XXXX .

@entity1 @entity8 @entity5072 @entity10471 @entity177 @entity540 @entity6898 @entity7991 @entity8611 @entity70661 @entity7167 @entity3243 @entity652 @entity2742 @entity10006
Fibroblast growth factors (FGFs) comprise a family of polypeptide growth factors implicated in the control of proliferation of glandular tissues. The aim of this study was to determine whether FGFs are produced in normal and abnormal parathyroid glands and if these tissues have the potential to respond to this growth factor family. We have examined the expression of @entity7991 (FGF-R) types 1 and 2 and of @entity70661 , and 7 in a series of @entity1 parathyroid tissues using the reverse transcription polymerase chain reaction (RT-PCR). Samples of 10 @entity3243 and 10 @entity5072 glands from @entity1 with @entity8 ( @entity2742 ) were compared with samples from normal parathyroid glands from @entity1 with primary @entity2742 in the study. @entity7167 was expressed in all samples and @entity7991 in most. @entity6898 and @entity540 were expressed in all samples at variable levels, with no correlation between disease type and amplified RT-PCR product levels. @entity10471 was expressed in normal parathyroid tissue and in all @entity652 but was absent in all but one of the @entity3243 glands from @entity177 @entity1 . @entity10006 was expressed at low levels in normal tissue and variably expressed in diseased tissue, in some instances at high levels. These findings suggest that parathyroid tissue is potentially responsive to FGFs. The absence of @entity10471 expression in all but one of the renal parathyroid samples compared with normal and adenomatous tissue requires further investigation. The presence of elevated levels of @entity10006 expression in abnormal parathyroid tissue may be significant, as the @entity10006 gene ( @entity10006 proto-oncogene) is located on chromosome 11q13.3, a region already identified as being susceptible to rearrangement/mutation in @entity8611 .
