Argemone oil induces genotoxicity in XXXX .

@entity1603 @entity19 @entity4 @entity4336 @entity15391
CONTEXT: Argemone mexicana L. is native to Mexico and the plant extracts are used in traditional medicine in India and South American countries. Argemone oil (AO) is a common adulterant of mustard oil in India and causes serious pathophysiological consequences leading to outbreaks of @entity4 among consumers. In vivo cytogenetic studies on the toxicological effects of AO and its component alkaloids are limited. OBJECTIVE: The present study was undertaken to evaluate the safety of AO by assessment of their in vivo genotoxic potential in bone marrow cells of @entity19 . MATERIALS AND METHODS: AO mixed in @entity4336 oil in the proportions of 0.01, 0.1, and 1   ml AO/kg body weight in a total volume of 10   ml/kg body weight and a single undiluted dose of AO (10   ml/kg body weight) were administered intraperitoneally in separate groups of male Swiss Albino @entity19 for 24   h. In addition, a single concentration of @entity15391 (SG) (50   mg/kg body weight) was also administered. Genotoxicity was evaluated by chromosome aberration (CA) and sister chromatid exchange (SCE) tests. @entity1603 ( @entity1603 ) differential technique was used to study the effect on cell replication by the calculation of average generation time (AGT). RESULTS: The minimum effective concentrations that produced significant frequencies of CA and SCE were 0.1 and 0.01   ml/kg, respectively. AO and SG induced an insignificant increase of AGT indicating that they are non-cytotoxic in the concentrations tested. DISCUSSION AND CONCLUSION: Our results confirm that AO is genotoxic even at low concentrations and its usage should be checked.
