Leisure-Time Spent Sitting and Site-Specific XXXX Incidence in a Large U.S. Cohort.

@entity1 @entity43 @entity0 @entity5344 @entity5 @entity1582
BACKGROUND: Time spent sitting is distinctly different from accumulating too little physical activity and may have independent deleterious effects. Few studies have examined the association between sitting time and site-specific @entity5 incidence. METHODS: Among 69,260 @entity1 and 77,462 @entity1 who were @entity5 -free and enrolled in the American @entity5 Society @entity5 Prevention Study II Nutrition Cohort, 18,555 @entity1 and 12,236 @entity1 were diagnosed with @entity5 between 1992 and 2009. Extended Cox proportional hazards regression was used to estimate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) of leisure-time spent sitting with total and site-specific @entity5 incidence. RESULTS: Longer leisure-time spent sitting, after adjustment for physical activity, BMI, and other factors, was associated with risk of total @entity5 in @entity1 (RR = 1.10; 95% CI, 1.04-1.17 for >= 6 hours vs. <3 hours per day), but not @entity1 (RR = 1.00; 95% CI, 0.96-1.05). In @entity1 , sitting time was associated with risk of @entity1582 (RR = 1.65; 95% CI, 1.07-2.54), invasive @entity0 (RR = 1.10; 95% CI, 1.00-1.21), and @entity43 (RR = 1.43; 95% CI, 1.10-1.87). There were no associations between sitting time and site-specific @entity5 in @entity1 . CONCLUSION: Longer leisure-time spent sitting was associated with a higher risk of total @entity5 risk in @entity1 , and specifically with @entity1582 , @entity5344 , but sitting time was not associated with @entity5 risk in @entity1 . Further research is warranted to better understand the differences in associations between @entity1 and @entity1 . IMPACT: For @entity1 , these findings support American @entity5 Society guidelines for @entity5 prevention to reduce sitting time when possible.
