Reassessment of Lhermitte's sign in XXXX .

@entity1 @entity15
UNASSIGNED: The reliability and diagnostic value of Lhermitte's sign in @entity15 ( @entity15 ) has not been fully established. The purpose of this study was to determine the clinical, neurophysiological and neuroradiological correlations of Lhermitte's sign in a cohort of @entity15 @entity1 and reassess the relevance of this phenomenon in the clinical history of the disease. A prospective study of 694 @entity1 with @entity15 and 110 age-matched healthy adults was evaluated by a structured questionnaire that included basic demographic data, age of onset, clinical characteristics of the disease, and the inquiry of Lhermitte's sign. Cranial and spinal magnetic resonance imagings (MRI) and median and tibial somatosensory evoked potentials (SSEP) were performed at the same time. One hundred and twelve (16  %) @entity1 were reported to have Lhermitte's sign; 582 (84  %) @entity1 did not experience Lhermitte's sign during their disease duration (P  <  0.026). No correlation was found between Lhermitte's sign and age, gender, EDSS, and disease duration; 88  % of @entity1 with Lhermitte's sign had a demyelinating lesion on the cervical MRI. In negative Lhermitte's sign group, 64  % @entity1 had a positive MRI. SSEP conductions were delayed in 92  % of @entity1 with positive Lhermitte's sign and in 70  % of @entity1 with negative Lhermitte's sign. Regarding the data, a significant correlation was found between MRI lesion and Lhermitte's sign (P  <  0.001), and between SSEP abnormality and Lhermitte's sign as well (P  <  0.001). This study underlines the relevance of this phenomenon with neuroradiological and neurophysiological abnormalities.
