XXXX -induced vasoconstriction is increased in intimal hyperplastic arteries of the @entity235 .

@entity235 @entity1373 @entity1063
@entity1063 -induced arterial contraction in vitro is known to be increased after endothelial denudation and during the subsequent development of intimal @entity1373 . We now report the response to @entity1063 in intimal-thickened iliac vessels in conscious @entity235 . Seven @entity235 underwent balloon catheter deendothelialization of the right iliac artery. Three weeks later, ultrasonic transducers were implanted on both iliac arteries to record dynamic vessel dimension. A catheter was inserted into the terminal abdominal aorta for drug infusion and blood pressure monitoring. The @entity235 were studied unsedated 2 days after instrumentation. @entity1063 was infused at doses that did not affect blood pressure (0.01 to 0.05 micrograms/kg/min). Control vessel diameter decreased from 5.2 mm +/- 0.3 to 5.1 mm +/- 0.3 (2.4% +/- 1.0% when standardized to baseline diameter) and intimal hyperplastic vessels from 6.2 mm +/- 0.4 to 5.7 mm +/- 0.4 (7.6% +/- 1.7%). The difference between control and intimal hyperplastic vessel vasoconstriction was significant at p less than 0.0025. The calculated reduction in total vessel cross-section area for control vessels was 4.5% +/- 1.9%. In intimal hyperplastic vessels total cross-sectional area was reduced by 14.5% +/- 3.3% by vasoconstriction and the luminal cross-sectional area was reduced by 17.9% +/- 0.7% by the intimal @entity1373 . These data suggest that luminal compromise due to intimal @entity1373 is compounded by increased sensitivity to @entity1063 . This effect, demonstrated in a large elastic artery shortly after endothelial denudation, may be of even greater significance in a smaller vessel with advanced intimal @entity1373 .
