Assessment of genotoxic potential of hridayarnava XXXX (a herbo-mineralo-metallic ayurvedic formulation) using chromosomal aberration and sperm abnormality assays.

@entity137 @entity19 @entity28062 @entity786 @entity1017 @entity85
OBJECTIVES: Herbo-mineral formulations are being successfully used in therapeutics since centuries. But recently, they came under the scanner for their metallic contents especially the presence of heavy metals. Hence it is the need of the hour to assess and establish the safety of these formulations through @entity137 studies. In line with the various @entity137 studies that are being carried out, Government of India expressed the need for conducting genotoxicity studies of different metal- or mineral-based drugs. Till date very few Ayurvedic herbo-mineral formulations have been studied for their genotoxic potential. The present study is aimed to evaluate the genotoxic potential of Hridayarnava @entity28062 . MATERIALS AND METHODS: It was prepared as per classical guidelines and administered to Swiss albino @entity19 for 14 consecutive days. Chromosomal aberration and sperm abnormality assay were done to evaluate the genotoxic potential of the test drugs. @entity786 (CP) was taken as positive group and results were compared. RESULTS: All treated groups exhibited significant body @entity1017 in comparison to CP group. Results revealed no structural @entity85 in comparison to the CP-treated group. CONCLUSION: Reported data showed that both tested samples of Hridayarnava @entity28062 does not possess genotoxic potential under the experimental conditions and can be safely used.
