Efficacy and safety of XXXX and its combination with @entity619 in @entity102 media. A randomised, double blind, parallel group, comparative study.

@entity1 @entity796 @entity102 @entity619 @entity230 @entity800
UNASSIGNED: The role of corticosteroid in @entity1 of @entity102 media (CSOM) is unknown. In the present study, the efficacy and safety of @entity800 alone (OA) and the @entity800 + @entity619 combination (ODC) is compared by studying clinical cure rates and adverse drug reactions in @entity1 with CSOM. After prior permission from the Institutional Review Board and written informed consent from @entity1 , pre-treatment clinical assessment and bacteriology of the middle ear discharge were done. The middle ear was categorised into active, mucoid or inactive according to the type of discharge. Grades of otorrhoea and size of tympanic membrane perforation were noted. CSOM with organisms sensitive to @entity800 were treated either with OA or ODC eardrops for a period of 15 days. Post-treatment clinical cure (when grade of otorrhoea become 0) was recorded on the 5(th), 10(th) and 15(th) days and bacteriological assessment was recorded at the last visit. All parameters were analysed using Fisher's exact test. A total 110 @entity1 were randomised. The most common microorganism associated with CSOM was @entity796 (45.45 %). Clinical improvement was seen in 84.61% and 86.79% of cases, but bacteriological improvement in only 82.69% and 77.35% of cases treated with OA and ODC, respectively. Shift of middle ear discharge from active to inactive was noted in 71.15% and 64.15% @entity1 by the 10th day in the OA and ODC groups, respectively. As there was no difference in clinical or bacteriological improvement, it may be unnecessary to combine @entity230 with topical antibiotic preparations for management of CSOM.
