Expression of glomerular @entity2289 in XXXX .

@entity1 @entity644 @entity8 @entity2289 @entity2316 @entity1456 @entity628 @entity1988 @entity1351 @entity1985 @entity631
@entity2289 ( @entity2289 ) and @entity1456 (tPA) are the major regulators of @entity1351 generation. Glomerular @entity2289 /tPA balance is involved in extracellular matrix turnover, as well as fibrin deposition in glomeruli. Renal biopsy specimens were obtained from 80 @entity1 with either primary or secondary @entity631 (10 @entity1 , minimal @entity1985 ; 6 @entity1 , @entity628 [ @entity628 ]; 10 @entity1 , @entity8 [ @entity8 ]; 24 @entity1 , mesangial proliferative @entity631 ; 15 @entity1 , @entity1988 ; 14 @entity1 , @entity2316 ; and 1 @entity1 , @entity631 ). We quantified glomerular @entity2289 and tPA messenger RNA (mRNA) by competitive polymerase chain reaction. We also determined @entity2289 mRNA localization by in situ hybridization. Glomerular @entity2289 mRNA levels in @entity1 with @entity628 and @entity8 were significantly greater than those of controls. There was a sixfold increase in @entity2289 -tPA mRNA ratio in @entity1 with @entity8 compared with the control group. In addition, glomerular @entity2289 mRNA level correlated with level of @entity644 . Conversely, there was no difference in tPA mRNA levels among types of @entity631 . These results suggest that suppressed glomerular fibrinolytic and proteolytic activity may be associated with the pathogenesis of @entity631 , especially in @entity628 and @entity8 .
