Healthy Nordic diet downregulates the expression of genes involved in inflammation in XXXX in individuals with features of the @entity209 .

@entity1 @entity20995 @entity9688 @entity54676 @entity9650 @entity26 @entity23 @entity10497 @entity209 @entity1386
BACKGROUND: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. OBJECTIVE: The objective was to explore whether the ND has an impact on gene expression in abdominal @entity1386 ( @entity1386 ) and whether changes in gene expression are associated with clinical and biochemical effects. DESIGN: Obese adults with features of the @entity209 underwent an 18- to 24-wk randomized intervention study comparing the ND with the @entity23 ( @entity23 ) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included @entity1 from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of   4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m(2)) <38. @entity1386 biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix). RESULTS: Altogether, 128 genes were differentially expressed in @entity1386 between the ND and @entity23 (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the @entity23 . Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., @entity9688 , @entity54676 ), adaptive immune response ( @entity9650 , @entity10497 ), and reactive @entity26 species ( @entity20995 ). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor kB. CONCLUSION: A healthy Nordic diet reduces inflammatory gene expression in @entity1386 compared with a @entity23 independently of body weight change in individuals with features of the @entity209 . The study was registered at clinicaltrials.gov as NCT00992641.
