Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute XXXX in @entity35 .

@entity788 @entity656 @entity39 @entity5 @entity12718 @entity13358 @entity568 @entity651 @entity35
Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of @entity656 ( @entity656 ). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental @entity656 in @entity35 . Methods. Acute @entity788 -like symptoms were first induced in @entity35 and then they were given different doses of DCQD (6   g/kg, 12   g/kg, and 24   g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of @entity35 were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory ( @entity12718 and @entity13358 ) and proinflammatory markers ( @entity5 @entity39 factor a and @entity568 ) and ameliorating the pathological damage in target tissues (P < 0.05). Conclusions. DCQD could alleviate pancreatic, intestinal, and @entity651 by altering levels of inflammatory cytokines in @entity656 @entity35 with tissue distribution of its components.
