Kidney and bladder calculi in spontaneously XXXX @entity35 .

@entity101 @entity28 @entity4 @entity1608 @entity1503 @entity1290 @entity460 @entity35
Naturally occurring @entity1290 are rare in animals. The Japanese strains of spontaneously @entity101 @entity35 (SHR) are normotensive at birth but develop @entity101 , hyperglycaemia and hyperlipidaemia as they mature. The SHR strain is prone to develop @entity1290 . A unique sub-strain of SHR has been developed in which some animals develop @entity28 concomitantly with their rising blood pressure, i.e. Obese/SHR. The Obese/SHR characteristically develop microscopic @entity1290 which become detached at an early stage of formation, migrate to the bladder, and grow by concretion into huge, rounded calculi. The stone nidus starts as a subepithelial cyst-like focus containing @entity4 , @entity1503 suspended on a delicate network of fibrils. THe nidi grow by concretion of an admixture of @entity460 and acidic protein in a lamellar arrangement. The disparate morphogenesis and anatomic location of @entity1290 in Obese is opposed to @entity28 /SHR suggest that @entity1608 formation may be governed by specific differences in genetic programming. The incidence of @entity1290 parallels the severity and chronicity of the @entity101 in SHR, @entity28 and Obese/SHR, and the Cushingoid habitus in the Obese/SHR.
