Prognostic Factors in XXXX with Symptomatic Spinal Metastases and Normal Neurological Function.

@entity1 @entity171 @entity5 @entity1745 @entity158
AIMS: To evaluate potential prognostic factors for predicting survival after radiotherapy in @entity1 with painful spinal metastases and normal neurological function. MATERIALS AND METHODS: In total, 173 @entity1 were included. The following prognostic factors were assessed: primary @entity5 site, age, gender, albumin and haemoglobin levels, Karnofsky performance status (KPS), analgesic use, @entity158 intensity, number of extraspinal bone metastases and visceral metastases, presence of @entity5 -conditioned spinal canal stenosis and metastatic @entity1745 , and extension of spinal metastatic disease on magnetic resonance imaging (MRI). Ongoing systemic treatment, use of @entity171 and response to radiotherapy were also evaluated. A simple scoring system for predicting survival was used. RESULTS: The following predictive factors were found to be significant in multivariate analysis: primary @entity5 site, KPS, albumin level, number of visceral metastases and analgesic use. Three survival groups were proposed. The overall survival probabilities for groups 1-3 were 13, 46 and 94% at 6 months; 4, 28 and 79% at 12 months, respectively. The median survival times for groups 1-3 were 2.1, 5.5 and 24.9 months, respectively (P  <  0.001). CONCLUSION: The pretreatment albumin level was a significant prognostic indicator for survival. Similarly, the primary @entity5 site, KPS and number of visceral metastases were associated with survival; these findings were consistent with the results of previous studies. The pretreatment analgesic use was significant using the univariate and multivariate analyses and this factor can be verified in future trials. Self-reported @entity158 intensity, @entity158 response to radiotherapy and MRI findings did not influence survival times.
