Risk of high-grade cervical XXXX and gynaecological @entity5 following the cytologic diagnosis of @entity1358 of undetermined significance: A retrospective study of a state-wide screening population in Western Australia.

@entity1204 @entity1 @entity5 @entity2622 @entity1358 @entity1478 @entity15709 @entity1141
BACKGROUND: In 2006, Australia adopted a revised cervical cytology terminology system, known as the Australian Modified Bethesda System (AMBS). One substantial change in the AMBS was the introduction of the diagnostic category of @entity1358 ( @entity1358 ) of undetermined significance. AIM: The aim of this study was to investigate the incidence of histologically confirmed high-grade cervical @entity1141 ( @entity5 ( @entity5 ) grades 2 and 3 and @entity15709 (ACIS)), @entity2622 and @entity1204 in @entity1 presenting with @entity1358 on cervical cytology. METHODS: A seven-year retrospective study examining clinical outcomes of @entity1 with @entity1358 on a screening cervical smear. Cytology and histology results were extracted from the Western Australia Cervical Screening Registry, and time-to-event analysis was used to predict the odds of having or developing in  situ and invasive @entity5 . RESULTS: @entity1358 was reported in index smears from 0.093% (584/622754) @entity1 during the study period. No follow-up was available in 35 @entity1358 cases. Sixty-five of the remaining 549 @entity1 (11.8%) had, or developed, high-grade cervical @entity1141 within five years of their index @entity1358 diagnosis. @entity1204 was diagnosed in 21 @entity1 and @entity5 in four @entity1 during the follow-up period. CONCLUSION: Cytologic demonstration of @entity1358 requires careful gynaecologic evaluation, particularly in younger @entity1 who may be found to have either high-grade squamous ( @entity5 ) or glandular (ACIS) lesions, while in older @entity1 , the possibility of @entity1478 needs to be considered.
