Eyes with large disc cupping and normal intraocular pressure: using optical coherence tomography to discriminate those with and without XXXX .

@entity1 @entity227 @entity16 @entity726 @entity735 @entity1781
We evaluated the ability of spectral-domain optic coherence tomography (SD-OCT) to differentiate @entity1781 ( @entity1781 ) from glaucomatous cupping in eyes with intraocular pressure (IOP) within the normal range. We prospectively enrolled @entity1 with @entity726 or presumed @entity1781 . @entity1 had optic discs with confirmed or suspected @entity16 (defined as a vertical cup-to-disc ratio>= 0.6), and all eyes had known untreated IOP<21 mmHg. For @entity735 , a reproducible glaucomatous @entity227 was required. @entity1781 eyes required normal VF and no evidence of progressive @entity16 (follow-up>= 30 months). Peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell complex (GCC) thicknesses were obtained using SD-OCT. For all studied parameters of pRNFL and GCC thicknesses, eyes with @entity726 (n=36) had significantly thinner values compared to eyes with @entity1781 (n=71; P<0.05 for all comparisons). In addition, pRNFL parameters had sensitivity of 66.7% and specificity of 83.1%, and GCC parameters had sensitivity of 61.2% and specificity of 81.7%. The combination of the two analyses increased the sensitivity to 80.6%. In conclusion, while evaluating @entity1 with large optic disc cupping and IOP in the statistically normal range, SD-OCT had only limited diagnostic ability to differentiate those with and without @entity726 . Although the diagnostic ability of the pRNFL and the GCC scans were similar, these parameters yielded an increase in sensitivity when combined, suggesting that both parameters could be considered simultaneously in these cases.
