Long-term follow up of XXXX -infected Korean haemophiliacs, after infection from a common source of virus.

@entity1 @entity9611 @entity404 @entity2858 @entity195 @entity1292 @entity9052 @entity4107
In the early 1990s, 20 haemophiliacs (HPs) were infected with a common source of @entity2858 viruses through the contaminated clotting factor IX. The aim of this study is to review 20 HPs infected with a common source of virus. The enrolled @entity1 have been consecutively treated with Korean red @entity9052 (KRG), @entity9611 (ZDV) or two-drug therapy and highly active antiretroviral therapy (HAART). We determined full-length pol gene over 20  years and human @entity4107 with peripheral blood mononuclear cells and reviewed medical records. Eighteen HPs experienced various @entity1292 or clinical manifestations. There were significant inverse correlations between the HLA prognostic score and the annual decrease in @entity404 + T-cell counts prior to HAART ( @entity195 ) (P  <  0.05) and the amount of KRG and the @entity195 (P  <  0.01). From 1998, the HPs had been treated with HAART. Each of the two @entity1 died without and with HAART regimen respectively. At present, 16 HPs have been alive with HAART. Among the 16 HPs, 12 and 4 are on HAART-plus-KRG and HAART only respectively. Eleven HPs including 2 HPs with G-to-A hypermutations had revealed resistance mutations. Ten and two HPs have shown poor adherence and incomplete viral suppres-sion on HAART respectively. Virological failure based on WHO guidelines was not observed on KRG-plus-HAART. Two HPs revealed additional resistance mutations against two classes on KRG-plus-HAART. As a nationwide study, we first report overall features on clinical course of Korean haemophiliacs. Further education on the importance of drug adherence is needed.
