The effect of age on the relationship between XXXX .

@entity1 @entity26 @entity64 @entity299
UNASSIGNED: Age-related changes in @entity299 are associated with increased risk of cardiovascular mortality and morbidity. The aim of the present study was to define the effect of age on the relationship between @entity299 . Haemodynamic and gas exchange measurements were performed at rest and peak exercise in healthy individuals. Augmentation index was measured at rest. Cardiac power output, a measure of overall cardiac function, was calculated as the product of cardiac output and mean arterial blood pressure. Augmentation index was significantly higher in older than younger @entity1 (27.7  10.1 vs. 2.5  10.1%, P<0.01). Older @entity1 demonstrated significantly higher @entity64 volume and mean arterial blood pressure (P<0.05), but lower heart rate (145  13 vs. 172  10 beats/min, P<0.01) and peak @entity26 consumption (22.5  5.2 vs. 41.2  8.4ml/kg/min, P<0.01). There was a significant negative relationship between augmentation index and peak exercise cardiac power output (r=-0.73, P=0.02) and cardiac output (r=-0.69, P=0.03) in older @entity1 . Older @entity1 maintain maximal cardiac function due to increased @entity64 volume. Vascular function is a strong predictor of overall cardiac function in older but in not younger @entity1 .
