Impaired peripheral vasoconstrictor response to orthostatic stress in @entity1 with XXXX .

@entity1 @entity1063 @entity9576 @entity5433 @entity551 @entity65
BACKGROUND AND PURPOSE: Most @entity1 with @entity9576 ( @entity9576 ) develop @entity5433 ; however, @entity551 is not always present. Failure of the vasoconstrictor response is thought to be responsible for @entity551 , but the degree of impairment of this response in @entity1 with @entity9576 is unclear. We assessed autonomic function in @entity1 with @entity9576 by evaluating the vasoconstrictive response during a head-up tilt test and determining its relationship to @entity551 . As an additional examination, the efficacy of @entity1063 in treating @entity551 was also assessed. METHODS: The study included 82 @entity1 with @entity9576 and 28 controls. Measures of total peripheral resistance were obtained during a head-up tilt test. @entity1063 was administered to the @entity1 lacking a vasoconstrictive response to evaluate its ability to treat @entity551 . RESULTS: At a 60   tilt, @entity551 occurred in 47.6% of the @entity1 and 0% of controls. Reduction in total peripheral resistance from baseline at a 60   tilt was observed in 69.5% of the @entity1 and 0% of controls. In @entity1 with @entity9576 , changes in systolic blood pressure from the baseline at a 60   tilt correlated positively with changes in the total peripheral resistance (r  =  0.69, p  <  0.0001). @entity1063 prevented the reduction of total peripheral resistance and development of @entity551 . CONCLUSIONS: A large number of @entity1 with @entity9576 with and without @entity551 have an impaired peripheral vasoconstrictive response, suggesting a high frequency of @entity65 with an associated risk of developing @entity551 . A @entity1063 infusion was effective for treating @entity551 .
