The natural leukocyte response to XXXX .

@entity1 @entity4485 @entity308 @entity548 @entity235 @entity2348 @entity880 @entity130
There is a high incidence of @entity2348 in @entity1 after @entity130 or @entity548 . Since circulating white blood cells (WBC) are a vital component of host defense mechanisms, we examined leukocyte responses in @entity235 @entity548 . Twenty adult mongrel @entity235 were anesthetized with 28.6 mg/kg of IV @entity4485 . Arterial and venous cannulas were inserted, and after baseline hemodynamic and blood determinations the @entity235 were rapidly bled into a reservoir to a mean arterial pressure of 45 +/- 3 mmHg. The animals were maintained at this pressure for one hour and then resuscitated with twice the volume of shed blood over two hours using Ringer's @entity880 solution. Serial WBC counts after shock were compared to baseline values using Student's t test. In the first few hours after @entity548 the total WBC count falls, while the neutrophil population rises significantly. During the first week following shock and resuscitation, the leukocyte count remains elevated due to a persistent increase in the neutrophil population. The lymphocyte count remains @entity308 . Therefore, changes in the number of WBC after @entity235 @entity548 do not favor the development of @entity2348 , because the neutrophil count remains elevated. Whether or not neutrophil function is adequate remains to be determined.
