Regional chemotherapy with the use of @entity900 and @entity632 as primary treatment for advanced XXXX in shoulder, pelvis, and thigh.

@entity1 @entity2828 @entity632 @entity242 @entity1418 @entity5 @entity900 @entity1352 @entity421 @entity1821
Eight @entity1 who had large @entity242 in the hip, thigh, or shoulder girdle have been described. Three had @entity421 , and one each had @entity2828 , biphasic @entity1352 , @entity1821 , undifferentiated spindling @entity242 , and @entity1418 . All eight @entity5 showed evidence of regression after intraarterial infusion of @entity900 and @entity632 ( @entity632 ) given over 48 hours at 3-week intervals, for a total of between three and seven courses. Tru-cut needle biopsy specimens of five of the lesions were normal after chemotherapy. However, after resection of the regressed @entity5 in seven of the @entity1 , four contained foci of probably viable malignant cells. These cell foci were intraosseous in three cases and in the wall of a cyst in one case. In the remaining case, @entity5 in the distribution of the infused artery regressed, but @entity5 in a region supplied by an artery that was not infused continued to enlarge. In one @entity1 with @entity421 in the pelvis, despite a good response to intraarterial chemotherapy that was followed by surgical resection and radiotherapy, @entity5 recurred in an adjacent area in tissues supplied by an artery not infused. A hindquarter amputation subsequently was required. With the exception of the two cases in which adequate @entity5 arterial infusion was not achieved, local @entity5 control was accomplished by intraarterial infusion chemotherapy followed by local resection or radiotherapy and local resection in all @entity1 . Four @entity1 are well without evidence of residual or metastatic @entity242 3.5 years after presentation in the case of an @entity421 of shoulder, 2.5 years after presentation in the case of a large @entity1821 of thigh and groin, 20 months after presentation in the case of lower-thigh @entity1418 , and 1 year after presentation in a @entity1 with an @entity421 of lower femur.
