Differential sensitivity to @entity1022 and lack of effect of XXXX on the pharmacology and physiology of propagated action potentials.

@entity1421 @entity1022 @entity4524 @entity1372 @entity13981 @entity3303 @entity4775 @entity35
1. We have studied the effects of @entity1421 ( @entity1421 ) on action potential propagation in the isolated, desheathed vagus and saphenous nerves of @entity35 using an extracellular grease gap recording method. 2. @entity1421 evoked a small depolarization of vagus nerves but had no effect on the stimulation threshold, size or latency of either the A wave (corresponding to conduction in A fibres) or the C wave (corresponding to conduction in C fibres) of the compound action potential (CAP) recorded from either @entity4775 . 3. @entity3303 (0.01 - 10 mM) reduced all components of the @entity4775 . @entity1421 had no significant effect on the sensitivity of any component of the CAP to @entity3303 . 4. @entity1022 ( @entity4524 , 10 microM) blocked completely both the A wave and the C wave of the CAP in either @entity4775 . 5. In saphenous nerve preparations the A wave was blocked by lower concentrations of @entity4524 than the C wave or any component of the CAP in @entity4775 which suggests that somatosensory A fibres express a different sub-type of @entity4524 -sensitive voltage-gated @entity1372 channel (VGSC) than somatosensory C-fibres or visceral sensory fibres. 6. Chemical activation of VGSCs with @entity13981 (10 or 50 microM) induced a depolarization in either nerve. The depolarization induced by 50 microM @entity13981 was blocked by 10 microM @entity4524 . 7. Although @entity4524 -insensitive VGSCs are expressed by some vagal and some somatosensory neurones they do not appear to be expressed functionally in the axons.
