Potential Impact of XXXX and Co-Morbidities Prevalent in Africa on Influenza Severity and Frequency: A Systematic Review.

@entity1 @entity10592 @entity3458 @entity7135 @entity683 @entity281 @entity325 @entity8453 @entity3147 @entity311 @entity166
@entity166 and underlying medical conditions common to Africa may affect @entity683 frequency and severity. We conducted a systematic review of published studies on @entity325 or co-morbidities that are prevalent in Africa: dengue, @entity311 , measles, meningococcus, @entity10592 ( @entity10592 ), @entity8453 , and @entity3147 . Articles were identified except for @entity683 and @entity10592 . Very few studies were from Africa. @entity3458 , @entity325 were found to increase the severity of @entity683 disease, though this is based on few studies of dengue and measles and the measles study was of low quality. The frequency of @entity683 was increased among @entity1 with @entity3458 . @entity281 increased the frequency of @entity7135 . Studies on @entity311 and @entity3147 found mixed results. Age-adjusted morbidity and mortality from @entity683 may be more common in Africa because @entity281 and diseases common in the region lead to more severe outcomes and increase the @entity683 burden. However, gaps exist in our knowledge about these interactions.
