Effects and Mechanism of Combination of Rhein and Danshensu in the Treatment of XXXX .

@entity1 @entity8 @entity589 @entity588 @entity7379 @entity740 @entity2533 @entity35
UNASSIGNED: Traditional Chinese medicine (TCM) plays a systemic role in disease treatment, targeting multiple etiological factors simultaneously. Based on clinical experience, rhubarb and Salvia miltiorrhiza are commonly prescribed together for the treatment of @entity740 ( @entity740 ) and have been proven to be very effective. However, the rationale of the combination remains unclear. The major active ingredients of these two herbs are rhein (RH) and danshensu (DSS), respectively. The aim of this paper is to investigate the renoprotective effects of RH and DSS in vitro and in vivo, and the underlying mechanism. A total of 5/6 nephrectomy @entity35 and @entity1 cells were subjected to chronic @entity8 . The combination of RH and DSS conferred a protective effect, as shown by a significant improvement in the renal function, blood supply, and fibrotic degree. Proinflammatory cytokines and adhesion molecules were suppressed by RH and DSS through NK-kB signaling. The combination also inhibited apoptosis by up-regulating @entity588 and down-regulating @entity589 . Inhibiting the @entity2533 / @entity7379 pathway was at least in part involved in the antifibrotic mechanism of the combination treatment of RH and DSS. This study demonstrates for the first time the renoprotective effect and the mechanism of RH and DSS combination on chronic @entity8 . It could provide experimental evidence to support the rationality of the combinatorial use of TCM in clinical practices.
