XXXX removal by haemoperfusion of whole blood in vivo.

@entity1 @entity8398 @entity95 @entity20031 @entity1503 @entity74 @entity2101 @entity4310 @entity731 @entity165
@entity4310 is caused by @entity74 in the cellular metabolism of @entity165 (C) and is characterized by high levels of low-density lipoproteins (LDL) and premature @entity731 . The C is carried in the plasma mainly as an LDL-C complex, and removal of the latter from plasma is highly desirable. This task can be achieved by selective haemoperfusion (HP), thereby eliminating the need for plasmapheresis. Agarose beads (2 per cent agarose, 0.85 to 1.4 mm in diameter) were prepared, and crosslinked with @entity20031 . Heparin and/or @entity8398 were subsequently attached. The beads thus obtained were found to be suitable for the removal of LDL-C from the whole blood of hypercholesterolaemic @entity95 , using a simple HP technique. A single two-hour HP treatment with a 40 ml column packed with active agarose beads resulted in a 30 per cent decrease in the C plasma level in the experimental animals. Our previous, in vitro, studies with the plasma of hypercholesterolaemic @entity1 showed a high selectivity of the beads for LDL. Yet when used with hypercholesterolaemic @entity95 , a relatively high amount of HDL was also removed from the blood. This can be attributed to a significant difference between the structure of @entity1 @entity2101 and that of @entity95 . Upon treatment of blood using the active agarose beads, no @entity1503 were detected, except for some prolongation of PT. It is to be hoped that this new system will replace the presently used and highly expensive plasmapheresis.
