XXXX trajectories and the association with metabolic adversities among the middle-aged adults.

@entity1 @entity2298 @entity308 @entity146 @entity14822 @entity209 @entity285
BACKGROUND: Despite both @entity308 and @entity209 confer substantial burden of disease, natural course of @entity308 and the relationship with metabolic adversities have not examined. We explore associations between trajectories of @entity308 and @entity209 , lifestyle factors and comorbidities. METHODS: This retrospective cohort study included 13,745 subjects (8113 @entity1 and 5632 @entity1 ) 40-59 years of age who underwent health examinations at the Seoul National University Hospital Healthcare System, Gangnam Center, in Korea. The median follow-up duration was 4.0 years. We estimated the mean trajectories of the Beck @entity308 Inventory scores using latent-class growth-curve analysis. RESULTS: We identified four distinctive trajectories of @entity308 in both sex. The probabilities of group membership were 35.1% (n=2374) in minimal, 47.4% (n=4545) in persistent-mild, 14.4% (n=987) in persistent-moderate, and 3.0% (n=207) in persistent-severe in @entity1 , and 36.3% (n=1883), 50.0% (n=3069), 12.3% (n=601) and 1.5% (n=79) in @entity1 . We found significant increasing trend in the prevalence of @entity209 in more severe depressive trajectory. The adjusted odds ratios of persistent-severe were significantly increased for the following variables: low HDL, @entity2298 , and @entity209 ( @entity209 ) in @entity1 and @entity2298 , @entity209 in @entity1 , and smoking, @entity285 consumption and lack of exercise in both genders. LIMITATIONS: Medical and @entity146 histories were obtained using a self-reported questionnaire rather than formal diagnostic assessments. CONCLUSIONS: The higher level of @entity308 trajectory was associated with @entity209 , especially @entity14822 , and several modifiable lifestyle factors. Our findings provide important implications for developing health policy and guidelines for reducing depressive symptom burden.
