Lymphotropic administration of photosensitizer as a model of target therapy of XXXX : experimental and clinical data.

@entity19 @entity32 @entity1 @entity5
BACKGROUND: The existence of zones of humoral skin-subskin tissue linkage with internal organs as well as the possibility of targeted administration of preparation into the affected organs were studied. METHODS: An experimental study of preparation and distribution in the bodies of @entity19 was held by both intravenous and lymphotropic methods of administration. By means of detection with a photosensitizer (as a marker), the study was conducted on healthy @entity19 and @entity19 with @entity32 . Based on the experimental results, the study has been implemented into the clinical practice of treatment of acute inflammatory diseases of testicle and its epididymis. @entity1 were administered antibiotics either by the lymphotropic method, or by traditional methods. RESULTS: The concentration of the preparation, administered by the lymphotropic method, maintained in target organs (testicles) at a high level for a longer time, while the intravenous injections provided fast achievement of high concentrations. Moreover there was a lower level of accumulation of the photosensitizer in parenchymal organs after subcutaneous (lymphotropic) administration. CONCLUSIONS: The presence of humoral connection of certain areas of skin and subcutaneous tissue with testicles and their epididymis was proved. It was found that the lymphotropic administration leads to earlier clinical improvement and normalization of laboratory indices, and, thus, to significant reduction in hospital stay. Such results open the possibility of targeted drug delivery to the diseased organs. In perspective, the method may be used in treating @entity1 not only in urology, but also in surgery, as well asfor many acute, chronic or @entity5 .
