Low @entity2245 plasma levels, a risk factor for @entity715 , in XXXX : role of inflammation and correlation with acute phase reactants.

@entity1 @entity15248 @entity2245 @entity1255 @entity31 @entity29 @entity715 @entity3562 @entity30 @entity1851
OBJECTIVES: Individuals with @entity29 ( @entity29 ) are at increased risk for @entity715 and @entity15248 . Low plasma levels of @entity2245 are an independent risk factor for @entity715 and may cause @entity3562 , another recognized risk factor for @entity715 . The aim of this study was to evaluate @entity2245 plasma levels in @entity29 @entity1 . METHODS: We studied 61 @entity29 @entity1 : 32 with @entity30 and 29 with @entity31 . For each @entity1 , three sex- and age-matched healthy control subjects were studied. RESULTS: Median @entity2245 levels were significantly lower in @entity29 @entity1 (22.0 pmol/L, range 3.6-231.0) than in controls (31.1 pmol/L, 3.7-363.4; p < 0.01). In all, 13.1% @entity29 @entity1 and 5.5% controls had plasma @entity2245 levels lower than the 5th percentile of distribution in normal controls (p < 0.05). Low @entity2245 levels were significantly more frequent in @entity1 with active disease than in @entity1 with quiescent disease (seven of 26, 26.9%, vs one of 35, 2.9%; p < 0.001). Moreover, @entity1 with active disease had significantly lower median @entity2245 levels (13.4 pmol/L, range 3.6-124.0) than @entity1 in a quiescent phase (27.0 pmol/L, 7.8-231.0; p < 0.001). Low @entity2245 levels were significantly correlated with serum concentrations of @entity1851 (r = -0.36, 95% CI = -0.59 to -0.09, p < 0.01) and alpha(1)-acid-glycoprotein (r = -0.37, 95% CI = -0.59 to -0.10, p < 0.01). @entity3562 was more frequent in @entity1 with low @entity2245 levels (three of eight, 37.5%) than in @entity1 with normal levels (nine of 53, 17.0%; p = 0.18). There was no statistically significant correlation between @entity2245 and @entity1255 plasma levels (r = -0.13, 95% CI = -0.37 to +0.14, p = 0.33). CONCLUSIONS: Low @entity2245 plasma levels, an independent risk factor for @entity715 , are frequent in @entity1 with @entity29 , especially those with active disease.
