Neuroprotective effects of XXXX from Abacopteris penangiana against oxidative stress-induced @entity2359 .

@entity137 @entity274 @entity19 @entity2041 @entity2197 @entity273 @entity16076 @entity98 @entity3649 @entity1234 @entity224 @entity71903 @entity1865 @entity2359
AIM OF THE STUDY: @entity71903 (AE) was isolated from Abacopteris penangiana (Hook.) Ching. This study was to elucidate its neuroprotective effects against @entity273 ( @entity274 ) induced oxidative damage in PC12 cells and @entity3649 ( @entity16076 ) induced @entity2359 in @entity19 brain. MATERIALS AND METHODS: In vitro, the protective effect of AE against @entity274 -induced oxidative damage in the PC12 was investigated by the method of @entity98 ( @entity98 ). In vivo, the protective effect of AE against @entity16076 -induced @entity2359 in @entity19 was studied. The @entity19 in the model group and the AE treatment groups were injected with the @entity16076 150 mg/(kg d) for 7 weeks while the @entity19 in the control group were injected with the same volume of saline (0.9%). From the sixth week, the treatment groups were subcutaneously injected 4 or 8 mg/(kg d) of AE. In order to explore the potential mechanism of AE's action, the @entity19 were assessed by behavioral and electrophysiological tests at the end of the administration. Then the @entity19 brain tissues were measured for the levels of @entity224 dismutases (SOD), @entity2041 peroxidase ( @entity2197 -Px), and @entity1234 ( @entity1865 ). RESULTS: This study showed that AE lowered the @entity274 -induced @entity137 , and AE significantly improved the learning and memory ability in behavioral performance. The biochemical examination revealed that AE restored the activities of SOD and @entity2197 -Px, and attenuated the increase of @entity1865 . Moreover, the electrophysiological analysis evidently showed that AE ameliorated the long-term potentiation (LTP). CONCLUSIONS: These results suggested that AE had neuroprotective effects, and its beneficial effects may be linked with inhibiting the generation of free radical and enhancing the activities of endogenous antioxidant enzymes.
