Fine-needle aspiration technique for the concurrent immunocytochemical evaluation of multiple biologic parameters in primary XXXX .

@entity172 @entity1 @entity0 @entity1420 @entity5 @entity876
Fine-needle aspiration cytology has been already established as a reliable method for the diagnosis of @entity0 . Its application has been recently extended to immunocytochemical analysis of biological parameters. In the current study @entity172 and @entity1420 receptors, Ki67 growth fraction, and @entity876 protein expression were immunocytochemically evaluated on the cellular material sampled by the same fine-needle aspirate used for the conventional cytologic diagnosis of @entity5 . Fine-needle aspiration specimens from 100 @entity1 with primary @entity0 were submitted to the immunocytochemical analysis. Twenty-eight percent were in premenopause; 23% had @entity5 with a diameter less than 2 cm, 59% from 2 to 5 cm, and 18% more than 5 cm; 60% had axillary nodal status negative, 34% positive, and 6% unknown. The concomitant immunocytochemical evaluation of all parameters was possible in 70% of the @entity1 . A significant association was found between @entity876 overexpression and Ki67 values (p = 0.004), and between Ki67 values and @entity1420 receptor status (p = 0.003). No correlation was found between any parameter and clinical @entity5 size. @entity172 (p = 0.02) and @entity1420 (p = 0.04) receptor negativity and high Ki67 growth fraction (p = 0.005) were significantly associated with the clinical evidence of axillary node involvement. This study suggests that fine-needle aspiration cytology represents an effective practice for a simultaneous evaluation of multiple biologic indicators and could be useful as a preoperative procedure in @entity1 who are candidates for neoadjuvant chemotherapy and/or endocrine therapy.
