Inherited and acquired risk factors for venous thromboembolic disease among @entity1 taking XXXX to prevent @entity0 .

@entity1 @entity5337 @entity0 @entity440 @entity174 @entity556 @entity715 @entity1211
PURPOSE: @entity1211 ( @entity1211 ) is of particular concern in @entity1 receiving @entity440 in a chemopreventive setting. We investigate the association between acquired and inherited risk factors for @entity1211 in the International @entity0 Intervention Study (IBIS-I) trial of @entity440 prophylaxis for @entity1 at increased risk of @entity0 . METHODS: We used a nested case-control study design to investigate the role of @entity440 and acquired risk factors in the risk of developing a @entity1211 . RESULTS: @entity440 was associated with a significantly increased risk of developing a major @entity1211 (odds ratio [OR], 2.1; 95% CI, 1.1 to 4.1). @entity1 who had surgery, immobilization, or @entity174 in the previous month had a greatly increased risk of developing a major @entity1211 (OR, 4.7; 95% CI, 2.2 to 10.1). @entity556 and @entity5337 mutations were found exclusively among control @entity1 : @entity5337 in eight of 159 control @entity1 (5.0%) and the @entity556 mutation in three control @entity1 (1.9%). Thirty-five @entity1 with a @entity1211 and a blood sample were negative for these mutations. The upper one-sided 97.5% CI for the OR of having either mutation was 1.87. Being overweight, smoking, or taking hormone replacement therapy was not associated with @entity1211 in this study, but the CIs were wide. CONCLUSION: @entity440 and prior surgery, @entity174 , or immobilization were associated with a significantly increased risk of developing a @entity1211 . @entity5337 and @entity556 mutations were not associated with @entity715 in this population.
