Long-term safety and sustained left ventricular recovery: long-term results of percutaneous left ventricular support with Impella LP2.5 in XXXX .

@entity1 @entity886 @entity1188 @entity583 @entity1002
AIMS: Mechanical left ventricular (LV) unloading may reduce @entity1188 size when combined with primary percutaneous coronary intervention (PCI) in @entity1 with @entity583 ( @entity583 ). The Impella LP2.5 is a novel percutaneous left ventricular assist device. Although the short-term safety and feasibility of this device have been demonstrated, the long-term effects are unknown. The purpose of the current study was to evaluate the long-term effects of the Impella LP2.5 support on the aortic valve and @entity1002 ( @entity1002 ). METHODS AND RESULTS: In 2006, 10 @entity1 with anterior @entity583 received 3-day support with the Impella LP2.5 after PCI. The control group consisted of 10 comparable @entity1 , treated according to routine care. For the current study, echocardiography was performed and adverse events were recorded. Mean duration of follow-up was 2.9  0.6 years in the Impella group and 3.0  0.3 years in the control group. No differences in @entity886 and @entity1002 were demonstrated between the groups; nevertheless, @entity1002 increase from baseline was significantly greater in Impella-treated @entity1 (23.6  8.9% versus 6.7  7.0%, P=0.008). CONCLUSIONS: Three-day support with the Impella LP2.5 is not associated with adverse effects on the aortic valve at long-term follow-up. @entity1002 was similar in both groups; however, recovery was significantly greater in the Impella group.
