@entity731 and XXXX are linked in the elderly. The Leiden 85-plus Study.

@entity1 @entity303 @entity73 @entity731 @entity65
Post-mortem analyses suggest that @entity731 more often contributes to late-onset @entity303 than hitherto expected. We set out to further unravel the relation between @entity731 and @entity73 . We therefore tested the hypothesis that the number of @entity65 is positively associated with @entity73 in elderly subjects, and that the smaller number of @entity65 in @entity1 explains the better cognitive function of elderly @entity1 . Within the Leiden 85-plus Study, we assessed the @entity731 burden by counting the number of @entity65 in the medical histories of a population-based sample of 599 subjects aged 85 years (response 87%). Significantly more @entity1 than @entity1 had a history of @entity65 (67% compared to 59%, P<0.001). In addition, cognitive function was assessed. All subjects completed the Mini-Mental State Examination (MMSE). Cognitive speed and memory were determined with specific neuro-psychological tests in those with a MMSE-score above 18 points. There was a highly significant dose-response relationship between the number of @entity65 and @entity73 for both @entity1 and @entity1 . The median MMSE-score was 26 points in subjects without @entity65 and decreased to 25 points for subjects who had two or more @entity65 (P for trend =0.003). Similar associations were found for cognitive speed but not for memory. Our data confirm that in old age @entity731 significantly contributes to @entity73 . Since treatments for @entity731 appear to be particularly effective in elderly @entity1 , we consider our finding of utmost clinical importance in possibly preventing @entity73 and late-onset @entity303 .
