XXXX of unresectable pancreatic carcinoma.

@entity1 @entity3883 @entity788 @entity1087 @entity6 @entity954 @entity5 @entity9727 @entity262 @entity3 @entity158 @entity34
The decision to perform surgical versus nonoperative palliation for unresectable @entity788 is influenced by a number of factors. In most cases, @entity1 symptoms clearly dictate the management. In @entity1 with symptoms of @entity9727 at the time of presentation, surgery is the only option. In @entity1 with @entity3883 , the options for management must be weighed against factors such as overall health status, projected survival, and procedure-related morbidity and mortality. A prospective multicenter trial recently analyzed factors influencing perioperative morbidity and mortality following both curative and palliative surgery for @entity788 . This analysis demonstrated that preoperative @entity6 , low Kanofsky's index, and liver @entity3 are significant risk factors in predicting perioperative morbidity and mortality in @entity1 undergoing palliative procedures for @entity788 . Another analysis focusing on @entity5 characteristics suggested that for @entity1 with Stage I and @entity34 (i.e., with no evidence of systemic @entity3 ), survival and the potential for late @entity9727 . In summary, although @entity1 management must be individualized, most @entity1 with @entity788 in good medical health and with no evidence of @entity262 are most appropriately managed with surgical palliation. This option affords @entity1 the best chance of avoiding the late complications of recurrent @entity1087 , @entity9727 , and disabling @entity158 . @entity954 can generally be completed with an acceptable perioperative morbidity and mortality and a hospital stay of approximately 2 weeks. Finally, only surgical exploration can offer full opportunity for resection for cure.
