XXXX and RH blood group polymorphisms affect blood pressure and lipids in Afro-Caribbeans.

@entity2178 @entity7742 @entity165 @entity3452
Population blood pressure variation is most likely due to multiple genes. This is likely the reason why monogenic testing with the @entity2178 ( @entity2178 ) gene polymorphisms on chromosome 1 (1q42-43), especially @entity7742 , has met with negative results, especially in those of African descent. The RH blood group system, also on chromosome 1 (1 p36.2-34), has likewise been associated with blood pressure variation in African-Americans and with the rise in blood pressure with age in whites. Using a random sample of the population, we investigated the combined effects of single and combined variation of the AGTN @entity7742 and RH genotypes on blood pressure, lipids, and lipoprotein concentrations in Afro-Caribbeans aged 18-60 years from the island nation of Dominica. In monogenic analysis, @entity2178 @entity7742 was not associated with blood pressure. However, it was associated with HDL (MM 42+/-23, MT 44+/-12, TT 52+/-14 (P=0.002)). RH genotype was significantly associated with systolic blood pressure (P=0.006) and @entity3452 (P=0.003). These effects remained after adjustment for age, gender, weight, and BMI. In the polygenetic analysis, @entity2178 @entity7742 and RH were significantly associated with systolic blood pressure (P=0.037; interaction effects, P=0.068). The association of the @entity2178 @entity7742 with blood pressure across RH blood group haplotypes was then tested. Of the five RH haplotypes available for analysis, the @entity2178 @entity7742 was significantly associated with blood pressure within the "D" haplotype (P=0.01). The RH blood group and gender were significantly associated with systolic blood pressure and @entity3452 levels (P=0.005 and 0.012, respectively). All interactions were independent of age and weight. In conclusion, we demonstrate a significant association of @entity2178 @entity7742 with blood pressure and @entity165 metabolism in an Afro-Caribbean population in the "genetic context" of the RH blood group system. Further investigation of these interactions may help understand the effects of genetic factors on cardiovascular risk in African-derived and other populations.
