Normal ranges and genetic variants of XXXX , protein C and protein S in the general Chinese population. Results of the Chinese Hemostasis Investigation on Natural Anticoagulants Study I Group.

@entity1 @entity29892 @entity23882 @entity1211 @entity715 @entity5582
BACKGROUND: Inherited deficiency of @entity5582 , protein C and protein S, three important, naturally occurring coagulation inhibitors, might play a major role in the occurrence of @entity1211 in Chinese. The establishment of age- and gender-related normal ranges of these inhibitors is crucial for an accurate diagnosis of these deficiencies. DESIGN AND METHODS: We designed a prospective cross-sectional study recruiting healthy adults from four university-affiliated hospitals in China. @entity5582 , protein C and protein S were studied by measuring their activity. Gene analysis was performed when @entity29892 was suspected. Polymorphisms of the factor V gene were searched for among subjects who were positive for activated protein C resistance. RESULTS: In 3493 healthy Chinese adults (1734 @entity1 , 1759 @entity1 ; age 17-83 years), we found higher age-adjusted activities for protein C and protein S in @entity1 than in @entity1 but no sex difference for @entity5582 . In @entity1 , mean protein C and protein S activities increased with age. In @entity1 , mean protein C levels increased with age up to the age of 49 but decreased after 50 years old; mean protein S levels decreased after 50 years of age. @entity5582 levels remained stable over time in @entity1 but decreased significantly after 50 years of age in @entity1 . Reference values according to age and sex allowed the identification of 15 genetic variants (protein @entity23882 , @entity5582 :3, protein S:2) in subjects with protein activity below the 1(st) percentile. CONCLUSIONS: This is the largest survey ever conducted in the healthy general Chinese population. These normal ranges provide the essential basis for the diagnosis and treatment of @entity715 in Chinese.
