Pathologic response after neoadjuvant chemoradiotherapy in Sudanese XXXX with locally advanced rectal adenocarcinoma.

@entity5 @entity1 @entity3 @entity1487
BACKGROUND: Locally advanced @entity5 can be down staged by neoadjuvant therapy and the resultant @entity5 response can be quantified histologically. OBJECTIVE: This study aimed to assess pathologic response of neoadjuvant chemoradiation in @entity1 with locally advanced @entity5 treated in Wad Medani Teaching Hospital (WMTH) and National @entity5 Institute (NCI), Wad Medani, Sudan. @entity1 AND METHODS: A total of 36 consecutive @entity1 with locally advanced @entity5 that were managed in WMTH and NCI during the period from 2006-2011 were reviewed. Preoperative pelvic radiotherapy was delivered. Total of 46 Gray were delivered concurrently with @entity1487 ( @entity1487 ) on the first and last week of radiation. Total mesorectal excision of the @entity5 either by anterior or abdominoperineal resections was planned at 6-8 weeks from completion of preoperative treatment. The pathological response to therapy was assessed by histopathology examination of the surgical specimen. RESULTS: Initial clinical staging of @entity1 revealed 58.3% of them were stage T3/T4N2M0 and 41.7% were stage T3N0M0. Down-staging to stage T1/T2N0M0 was found in 36.1% and stage T3N0M0 in 30.6%. No response was seen in 8.3% of cases with stage T3/T4N2M0 while complete clinical response (no residual) was seen in 25.0%. Complete histological response was observed 13.8%. Positive lymph-nodes @entity3 was confirmed in 8.3% of cases. CONCLUSION: Neoadjuvant chemoradiation is a reasonable option for cases of @entity5 and deserves further evaluation.
