Defective @entity4311 / @entity6756 protein expression is seen infrequently in @entity31 associated XXXX .

@entity1 @entity6756 @entity124 @entity5 @entity31 @entity4311 @entity14
BACKGROUND: @entity31 is associated with an increased risk of @entity14 above that of the normal population. The relative risk correlates with the extent and duration of the disease but the genetic basis of @entity31 associated @entity5 risk is not known. AIMS: To assess the prevalence of @entity124 and mismatch repair gene abnormalities in @entity31 associated @entity14 . @entity1 : Forty six @entity1 with @entity14 , with a previous histological diagnosis of @entity31 . METHODS: The frequency of @entity124 and/or immunohistochemical expression of @entity4311 and @entity6756 was assessed. Thirty three cases were investigated using both approaches. RESULTS: Although 6/41 (14.6%) cases showed @entity124 at one or more markers, only one case (2. 4%) exhibited high level instability (at least two markers affected). Of 38 cases which were assessed using antibodies against @entity4311 and @entity6756 , only one case (2.6%) showed loss of expression. This case, which showed loss of @entity4311 expression, was the same case which exhibited high level @entity124 . The 33 cases which were investigated using both approaches showed that loss of expression of either @entity4311 or @entity6756 was not seen in any case which exhibited @entity124 in no more than one marker. CONCLUSIONS: This study suggests that both high level @entity124 and loss of expression of @entity4311 / @entity6756 are infrequent events in @entity31 associated @entity14 . Low level @entity124 was not associated with loss of expression of either @entity4311 or @entity6756 .
