Evaluation of monoaminergic neurotransmitters in the @entity35 striatum during varied global XXXX .

@entity3884 @entity2806 @entity63 @entity935 @entity750 @entity35 @entity551 @entity528
Neurotransmitter release during @entity2806 has been extensively studied and is thought to play a key role in excitotoxic @entity528 . The changes in neurotransmitter release and its metabolism may reflect changes in cellular metabolism during @entity63 . The purpose of this study is to assess alterations in extracellular @entity935 and @entity750 and their metabolites under varied degrees of @entity63 in @entity35 striatum to elucidate the pathophysiology of @entity2806 . Twenty @entity35 were used to induce varied @entity63 by means of bilateral common carotid artery occlusion along with hemorrhagic @entity551 . Cerebral blood flow (CBF) in the striatum was measured every 40 minutes by methods of @entity3884 clearance and maintained within certain ranges for 6 hours. @entity935 , @entity750 , and their metabolites were measured every 20 minutes by in vivo microdialysis. Varying degrees of @entity63 were obtained, ranging from 9.4 to 81.3% of control CBF. The animals were divided into three groups according to CBF levels measured 20 minutes after the induction of @entity63 . In the mild @entity63 group (n = 5), CBF ranged from 65 to 88% of baseline levels and resulted in only a slight increase of @entity935 . In the moderate @entity63 group (n = 10), CBF ranged from 21 to 48% of baseline levels and resulted in transient increases of @entity935 (24-fold) and @entity750 (5-fold). In the severe @entity63 group (n = 5), CBF was below 14% of baseline levels and resulted in marked increases in @entity935 (462-fold) and @entity750 (225-fold). These alterations remained elevated for 3 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
