Enzymatic estimation of skeletal XXXX by analysis of changes in serum @entity908 kinase.

@entity1 @entity583 @entity121 @entity908
Skeletal @entity121 size (SMDS) was assessed in 35 @entity1 and 34 @entity1 runners after a 42.2-km race using a method developed for estimation of @entity583 size. SMDS was computed according to the following equation: SMDS = (BW) (K) (CKr), where BW is body weight, K is a constant, and CKr is the cumulative amount of @entity908 kinase (CK) released over time. The method takes into account CK distribution space, fractional disappearance rate of CK, proportion of CK degraded in skeletal muscle, and proportion of CK released into the circulation. Assumptions are made regarding the relative amount of CK lost from skeletal muscle into the circulation. The SMDS in @entity1 , 808 +/- 1,229 (SD) CK g-eq was significantly (P less than 0.05) greater than in @entity1 , 160 +/- 147 (SD) CK g-eq. The ranges of SMDS (CK g-eq) were 23-5,397 in @entity1 and 7-624 in @entity1 . A significant difference (P less than 0.05) also remained after correction for body surface area; @entity1 432 +/- 583 (SD), @entity1 100 +/- 63 (SD) CK g-eq/m2. In @entity1 and @entity1 , no significant correlation existed between SMDS and age or marathon finish time. Although relatively theoretical, results indicate that greater skeletal @entity121 occurred in @entity1 vs. @entity1 runners after a marathon. Whether the release of CK from skeletal muscle is the result of irreversible and/or reversible injury has not yet been determined.
