Intergenerational effects of XXXX and reduced intrauterine growth: a population-based study of Swedish mother-offspring pairs.

@entity1 @entity600
OBJECTIVE: To estimate the intergenerational effects of @entity600 and reduced intrauterine growth. DESIGN: Population-based cohort study. SETTINGS: Mother-first-born offspring pairs recorded in the Swedish Medical Birth Registry. POPULATION: @entity1 born before 2001 to 38 720 @entity1 born in 1973-75. METHODS: The relationships between the mother's and the @entity1 's birth characteristics were estimated using logistic regression analysis. Adjustments were made for smoking habits, body mass index (BMI), and current and childhood socio-economic conditions. Analyses were performed on all mother-offspring pairs and on the pairs for which information on neither of the included background variables was missing (n= 24 520). MAIN OUTCOME MEASURES: Preterm birth (<37 weeks of gestation) and small for gestational age (SGA) (<-2 SD of the Swedish standard). RESULTS: Mothers who themselves had been born preterm were not significantly more likely to deliver their own @entity1 preterm, compared with those who had been born at term (adjusted OR 1.24, 95% CI 0.95-1.62). Also, @entity600 in the mothers did not influence the occurrence of SGA in the @entity1 . However, the odds ratio for giving birth to SGA and preterm @entity1 , respectively, was higher among SGA mothers (OR 2.68, 95% CI 2.11-3.41 and OR 1.30, 95% CI 1.05-1.61). Mothers whose intrauterine growth was moderately reduced but who did not meet the criterion of being born SGA were also at higher risk of giving birth to both preterm and SGA @entity1 , respectively. CONCLUSIONS: The present study showed evidence of intergenerational effects of reduced intrauterine growth even when socio-economic factors as well as BMI and smoking were adjusted for. There was, however, no consistent intergenerational effect of @entity600 .
