Pathologic Manifestations on Surgical Biopsy and Their Correlation with Clinical Indices in XXXX with Degenerative Mitral Valve Disease.

@entity1 @entity712 @entity296 @entity82 @entity235 @entity179
BACKGROUND: Evaluation of myocardial function is clinically challenging in @entity235 with @entity179 ( @entity179 ). Although @entity296 is caused by pathologic degeneration, histopathologic progression is poorly understood. OBJECTIVES: To characterize myocardial and pulmonary pathologic changes according to severity in @entity235 with naturally occurring @entity179 , and to investigate whether or not pathologic degeneration is reflected by traditional clinical indices. ANIMALS: One hundred and seventeen @entity235 with naturally occurring @entity179 . METHODS: Prospective observational study. Biopsied left atrium (LA), left ventricle (LV), and lung were evaluated histologically, and an attempt was made to correlate pathologic findings with clinical indices. RESULTS: Severe myocardial changes were observed in all International Small Animal Cardiac Health Council classes. In the lung, @entity712 cell levels were significantly increased in class III @entity1 (P  <  .0001). In a paired comparison, the LA showed significantly more severe degeneration than the LV, including myocardial fatty replacement, immune cell infiltration, and interstitial @entity82 (P  <  .0001). In contrast, myocardial cells were more hypertrophied in the LV than in the LA (P  <  .0001). Left ventricular end-diastolic dimension (LVEDd) was associated with fatty replacement (P  =  .033, R(2)   =  0.584) and myocardial vacuolization (P  =  .003, R(2)   =  0.588) in the LA. CONCLUSIONS AND CLINICAL IMPORTANCE: In @entity179 , although severe pathologic changes may be evident even in early stages, there may be pathologic discrepancy between the LA and the LV. @entity296 may be reflected by clinical indices such as LVEDd and EF.
