Conventional examination versus immunohistochemistry in the prediction of hormone profile of XXXX . An analysis on 142 cases.

@entity5 @entity11 @entity2124 @entity1653 @entity1710 @entity977 @entity652 @entity4903
The large majority of @entity5 located in the sella turcica are benign @entity977 derived from cells of the adenohypophysis. @entity977 represent the third most common primary @entity5 in neurosurgical practice, outnumbered only by @entity11 and @entity1653 . Their biology of @entity977 is complex and they can cause a @entity4903 , based on hormone profile secreted by proliferating cells. The aim of this study was to evaluate the routine conventional methods and highly specific immunohistochemical methods in order to accurately predict the type of hormone secretion. Our study was investigated 142 cases admitted with @entity977 and treated by open surgery. Sections from each case were stained with routine @entity1710 and Eosin method for histopathologic evaluation. Immunohistochemistry was performed on additional slides in order to detect specific @entity977 . Based on the immunohistochemical profile of @entity977 we found following results: 37 @entity2124 ( @entity2124 )-secreting @entity652 , 23 prolactin (PRL)-secreting @entity652 , 15 mixed @entity2124 -cell/PRL-cell @entity652 , three mammosomatotroph cell @entity652 , two adrenocorticotrophic hormone (ACTH)-secreting @entity652 , one thyrotrophic cell adenoma, 18 gonadotroph @entity652 , 30 null cell @entity652 and 13 plurihormonal @entity652 . No correlation was found between conventional features and the immunohistochemical profile. The immunohistochemical profile of functional @entity977 is mandatory for a correct diagnosis. We revealed that staining characteristics of the @entity5 cells, such as acidophilic, basophilic or chromophobe are nowadays outdated as main principle of classification, because they not identify specific @entity652 .
