XXXX -related angiosarcoma of the liver. Pathomorphologic study of 29 autopsy cases.

@entity5 @entity384 @entity5072 @entity5426 @entity3741 @entity1210
We describe the pathomorphologic features of 29 autopsy cases of @entity3741 -related @entity5426 ( @entity5426 ) of the liver. The average (+/- SD) latent period after @entity3741 injection was 36.2 +/- 5.2 years. Macroscopically, @entity3741 -related @entity5426 was divided into four types as follows: diffuse micronodular, multinodular, massive, and mixed multinodular and massive. Diffuse-micronodular and multinodular types were the most common. Histologically, @entity3741 -related hepatic @entity5426 was characterized by two cell types (spindle-shaped cells and polyhedral cells) and two structural patterns (sinusoidal and solid). There was no case composed of a solid pattern only. Immunohistochemically, factor VIII-related antigen was found to be positive in the endothelial cells of normal blood vessels and in the @entity5072 endothelial cells of the sinusoids, but negative in the @entity5 cells. @entity1210 was found in both the @entity5 and nontumorous areas in four cases. Erythrophagocytosis by the @entity5 cells was found in three cases. In the nontumorous area, varying degrees of @entity384 with frequent @entity5072 changes of the sinusoidal lining cells were observed in all cases. These sinusoidal changes were frequently contiguous to @entity5426 foci and were considered as a precursor change. In addition to the dominant sinusoidal changes, nodular hepatocytic hyperplasia was observed in two cases.
