Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in XXXX .

@entity1 @entity24845 @entity177 @entity1468
INTRODUCTION: The @entity24845 ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and plasma soluble (P)RR [s(P)RR] levels are associated with blood pressure elevations and renal function during pregnancy. METHODS: We conducted a cross-sectional study, conducted at Saitama medical center in 2010-2013. Preeclamptic @entity1 (n  =  16) diagnosed according to the criteria of Japan Society of Obstetrics and Gynecology and normotensive pregnant @entity1 (n  =  15) participated in the study. We measured the expression of (P)RR in the placenta, plasma s(P)RR levels, systolic blood pressure (SBP), and estimated glomerular filtration rate (eGFR). RESULTS: Placental expression of (P)RR was significantly higher in preeclamptic @entity1 than in normotensive pregnant @entity1 . The plasma s(P)RR levels were significantly higher in preeclamptic @entity1 than in normotensive pregnant @entity1 . Systolic blood pressure (SBP) was positively correlated with placental (P)RR levels (P  =  0.0001) and plasma s(P)RR levels (P  =  0.005) in all pregnant @entity1 . In preeclamptic @entity1 , SBP was positively correlated with placental (P)RR levels (P  =  0.004), but not with plasma s(P)RR levels (P  =  0.15). The eGFR was negatively correlated with placental (P)RR levels (P  =  0.02) and plasma s(P)RR levels (P  =  0.0002) in all pregnant @entity1 . In preeclamptic @entity1 , eGFR was negatively correlated with plasma s(P)RR levels (P  =  0.006), but not with placental (P)RR levels (P  =  0.93). DISCUSSION: Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of @entity177 in @entity1468 .
