Bone mineral density enhances use of clinical risk factors in predicting ten-year risk of @entity3604 in Chinese @entity1 : the Hong Kong XXXX Study.

@entity3604 @entity1 @entity174 @entity170 @entity79 @entity173
This prospective study aimed to determine the risk factors and the 10-year probability of @entity3604 in Southern Chinese @entity1 . The findings show substantial population differences in @entity174 incidence and risk prediction compared to the FRAX(TM) model, and the addition of @entity79 information to clinical risk factor assessment improved @entity174 risk prediction in Chinese @entity1 . INTRODUCTION: Clinical risk factors with or without @entity79 ( @entity79 ) measurements are increasingly recognized as reliable predictors of @entity174 risk. Prospective data on @entity174 incidence in Asian @entity1 remain sparse. This prospective study aimed to determine the risk factors and the 10-year absolute @entity174 risk in Southern Chinese @entity1 . METHODS: This is a part of the Hong Kong @entity170 Study. One thousand eight hundred ten (1,810) community-dwelling, treatment-naive @entity1 aged 50  years or above were evaluated. Baseline demographic characteristics, clinical risk factors and @entity79 were recorded. Ten-year risk of @entity3604 was calculated using Cox proportional hazards models. RESULTS: The mean age of subjects was 68.0        10.3  years. After a mean follow-up period of 3.5  2.9  years (range 1 to 14  years), 37 incident low-trauma @entity174 were recorded. The incidence for all @entity3604 and @entity173 was 635/100,000 and 123/100,000 @entity1 -years, respectively. The most significant predictors of @entity3604 were history of fall (RR 14.5), femoral neck @entity79 T-score   <   -2.5 (RR 13.8) and history of @entity174 (RR 4.4). Each SD reduction in @entity79 was associated with a 1.8 to 2.6-fold increase in @entity174 risk. Subjects with seven clinical risk factors and @entity79 T-score of -1 had an absolute 10-year risk of @entity3604 of 8.9%, but this increased to 22.7% if they also had a femoral neck @entity79 T-score of -2.5. CONCLUSIONS: These findings show substantial population differences in @entity174 incidence and risk prediction. The addition of @entity79 information to clinical risk factor assessment improved @entity174 risk prediction in Chinese @entity1 .
