XXXX kinetics and when to commence dialysis.

@entity1 @entity6 @entity1133 @entity177 @entity1011
Blood @entity1133 and serum @entity1011 levels are important factors in deciding when to start dialysis. Recently, in the assessment of dialysis adequacy, emphasis has shifted from reliance on these parameters to use of kinetic methods. We therefore applied @entity1133 kinetic modelling (UKM) to 63 consecutive @entity177 ( @entity177 ) @entity1 at the time dialysis commenced and compared the results to those obtained after 6 months of dialysis treatment. Mean normalised @entity1133 clearance (daily KT/V) at the commencement of dialysis (KTi/V) was 0.15 +/- 0.05, a level indicative of underdialysis in regularly dialysed @entity1 . After 6 months, mean daily KT/V was 0.35 +/- 0.12 in @entity1 subsequently established on CAPD, and 0.49 +/- 0.08 in those subsequently haemodialysed (both p < 0.001 compared to mean KTi/V). Serum @entity1011 levels on commencing dialysis were similar to those after 6 months treatment by either mode. Mean age (p < 0.01) and co-morbidity index (p < 0.05) were higher, and mean KTi/V lower (p < 0.05) in the 6 @entity1 who died during a mean follow-up period of 10 +/- 4.5 months than in survivors. Hospitalisation rates during follow-up (excluding admissions for access surgery and training) correlated with age (r = 0.332, p < 0.01), co-morbidity index (r = 0.351, p < 0.01) and KTi/V (r = -0.302, p < 0.05). Blood @entity1133 and serum @entity1011 levels on commencing dialysis were the same in those who died and in survivors and did not correlate with hospitalisation rates. @entity6 started dialysis with a similar mean KTi/V to non-diabetics but with a lower mean serum @entity1011 (p < 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
