Untreated Mild XXXX During Pregnancy and Anthropometric Measures of Obesity in Offspring at Age 5-7 Years.

@entity1 @entity6 @entity28 @entity4854 @entity413
OBJECTIVE: Obesity in the offspring of @entity1 with @entity4854 during pregnancy has been reported, but the results are conflicting. This study examined the association of @entity4854 during pregnancy and anthropometry in 5- to 7-year-old offspring whose mothers participated in the @entity4854 and Adverse Pregnancy Outcomes (HAPO) Study at the Belfast Centre. RESEARCH DESIGN AND METHODS: @entity1 in the HAPO study underwent a 75-g oral @entity413 tolerance test (OGTT) at approximately 28 weeks of gestation. Mothers and caregivers remained blinded to the results unless the fasting plasma @entity413 (FPG) concentration was >5.8 mmol/L or the 2-h plasma @entity413 (2hPG) concentration was >11.1 mmol/L. Offspring weight, height, and skin-fold thicknesses (triceps, subscapular, and suprailiac) were measured at age 5-7 years. Overweight, @entity28 , and extreme @entity28 were defined as a BMI z score >= 85th, >= 95th, and >= 99th percentile, respectively, based on the 1990 British Growth Standard. RESULTS: Belfast HAPO offspring (n = 1,320, 82%) aged 5-7 years attended for follow-up. Using multiple regression, maternal FPG, 1h PG, and 2hPG did not show any relation to offspring BMI z score or offspring skin-fold sum independent of maternal BMI at OGTT and offspring birth weight z score. This lack of association with maternal glycemia persisted with the offspring BMI z score expressed as >= 85th, >= 95th, or 99th percentile, and the sum of skin folds expressed as >= 90th percentile specific for sex. The initially significant relation between FPG and all offspring adiposity measures was explained by maternal BMI at the OGTT. CONCLUSIONS: After adjustment for maternal BMI at the OGTT, higher maternal FPG concentration during pregnancy (short of @entity6 ) is no longer a risk factor for @entity28 , as reflected by BMI and the sum of skin folds in offspring aged 5-7 years.
