Oxidative stress in expired breath condensate of XXXX with @entity1030 .

@entity1 @entity32 @entity274 @entity1353 @entity7707 @entity273 @entity1030
OBJECTIVE: To evaluate the levels of @entity273 ( @entity274 ) and @entity7707 in the expired breath condensate (EBC) of @entity1 with @entity1030 , and to assess the relationship between the above markers of oxidative stress and parameters expressing inflammatory process and disease severity. SETTING: Inpatient respiratory unit and outpatient clinic in tertiary care hospital. DESIGN: Cross-sectional study. @entity1 : Thirty stable @entity1030 @entity1 (all smokers) with disease severity ranging from mild to severe. Ten subjects who were smokers with stage 0 disease (ie, at risk for @entity1030 ; mean [+/- SD] FEV(1), 88 +/- 5% predicted) were studied as a control group. METHODS: @entity274 and @entity7707 levels were measured in EBC, and the values were correlated with variables expressing @entity1030 severity (ie, FEV(1) percent predicted, @entity1353 severity score (ie, Medical Research Council scale) and airway @entity32 (ie, differential cell counts from induced sputum). RESULTS: The mean concentration of @entity274 was significantly elevated in @entity1030 @entity1 compared to control subjects (mean, 0.66 micromol/L [95% confidence interval (CI), 0.54 to 0.68 micro mol/L) vs 0.31 micro mol/L [95% CI, 0.26 to 0.35 micromol/L], respectively; p < 0.0001). The difference was primarily due to the elevation of @entity274 in @entity1 with severe and moderate @entity1030 , whose expired breath @entity274 levels were significantly higher than those of @entity1 with mild disease (mean, 0.96 micromol/L [95% CI, 0.79 to 1.13 micromol/L], 0.68 micromol/L [95% CI, 0.55 to 0.81 micromol/L], and 0.33 micromol/L [95% CI, 0.24 to 0.43 micromol/L], respectively, p < 0.0001). The mean concentration of @entity7707 was significantly elevated in @entity1 with @entity1030 compared to that of the control group (47 pg/mL [95% CI, 41 to 53 pg/mL] vs 29 pg/mL [95% CI, 25 to 33 pg/mL], respectively; p < 0.0001) but did not differ significantly among the different stages of the disease (p = 0.43). Repeatability and stability data within measurements showed that @entity274 has a better repeatability and stability than @entity7707 . Furthermore, we observed significant correlations of @entity274 with FEV(1), neutrophil count, and @entity1353 score. Those correlations existed only in @entity1 with moderate and severe disease. No correlations were found between levels of @entity7707 and the above parameters. CONCLUSIONS: We conclude that levels of @entity274 and @entity7707 are elevated in the EBC of @entity1 with @entity1030 , but that @entity274 seems to be a more repeatable and a more sensitive index of the inflammatory process and the severity of the disease.
