Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature XXXX .

@entity410 @entity7504 @entity30395 @entity10495 @entity35 @entity12994
OBJECTIVE: Brivaracetam (BRV) is a new antiepileptic drug candidate rationally designed for high affinity and selectivity for the @entity30395 . This study explored anti-ictogenic and antiepileptogenic effects of BRV in @entity35 at different stages of development. METHODS: Using a rapid kindling model in @entity10495 , @entity7504 , @entity12994 , and P60 @entity35 , we studied two doses of BRV: 10 and 100  mg/kg injected intraperitoneally 30  min before afterdischarge assessment. We also assessed blood and brain concentrations of BRV 30  min after the injection. RESULTS: BRV 100  mg/kg significantly increased the afterdischarge threshold (ADT) at all ages, whereas BRV at 10  mg/kg increased ADT in P60, @entity12994 , and @entity7504 @entity35 . BRV also shortens the afterdischarge duration (ADD), achieving statistical significance with 10 and 100  mg/kg at P60 and with 100  mg/kg at @entity7504 . At P60, BRV increases the number of stimulations required to achieve a stage 4-5 @entity410 in a dose-dependent manner. At @entity12994 and @entity7504 , BRV increased the number of stimulations required to develop a stage 4-5 @entity410 in a dose-dependent manner with almost complete elimination of stage 4-5 @entity410 . In contrast, at @entity10495 , BRV had no effect on the number of stage 4-5 @entity410 . An age-related decrease in blood and brain concentrations of BRV was observed 30  min after injection of BRV 10  mg/kg, whereas with 100  mg/kg there were no significant age-correlated differences in brain and serum BRV concentrations. SIGNIFICANCE: BRV exerted dose-dependent anti-ictogenic effects from P60 to @entity10495 independent of brain maturation. BRV also exhibited antiepileptogenic effects at P60, whereas this effect need to be further evaluated at @entity12994 and @entity7504 . We did not observe any effect on epileptogenesis at @entity10495 at either dose.
