@entity619 effects on vascular volume and tissue hematocrit in experimental RG-2 XXXX and adjacent brain.

@entity1313 @entity5 @entity228 @entity11 @entity619 @entity35
We have studied the effects of @entity619 , a @entity228 commonly used to treat @entity1313 , on vascular volume and tissue hematocrit in RG-2 experimental @entity35 @entity11 . 125I-RISA (radioiodinated serum albumin) was used to measure tissue plasma vascular volume (Vp) and 51Cr labeled red cells were used to measure tissue red cell volume (Vrbc). Quantitative autoradiography was used to obtain local measurements of Vp and Vrbc in different brain and @entity5 regions. From these experimentally measured values, we calculated the tissue vascular volume (Vv), tissue hematocrit (THct) and systemic arterial hematocrit (AHct). The value reported primarily reflect capillary and small vessel volumes since blood drained from larger vessels during tissue processing and large vascular structures were avoided during analysis of the autoradiographic images. A total of 110 @entity5 were studied in 29 animals. There was a consistent trend for Vp and Vv to be reduced in all @entity5 regions after @entity619 treatment, although a significant decrease was seen only in @entity5 center. @entity619 did not affect Vp or Vv in @entity5 -free brain regions. @entity619 appeared to have little effect on Vrbc in any brain or @entity5 region. THct was consistently, although not significantly, higher in @entity5 after treatment with @entity619 ; THct in @entity5 -free brain regions was unaffected by @entity619 treatment.
