Proteolytic enzyme treatment reduces @entity8 and @entity644 in passive XXXX .

@entity644 @entity8 @entity95 @entity1011 @entity35 @entity8157
We investigated the effect of proteolytic enzyme treatment on the course of passive @entity8157 (PHN). PHN was induced by intravenous injection of Heymann antibody into @entity35 . Protease-treated @entity35 received intraperitoneal chymopapain and subtilisin. In @entity35 given subnephritogenic doses of Heymann antibody (5 or 10 mg, insufficient to cause @entity644 ), @entity8 were assessed by immunofluorescence and electron microscopy. In @entity35 given 5 mg Heymann antibody and treated with protease in the heterologous phase of the disease (days 1-7), fewer animals were positive for rabbit IgG and rat IgG, as determined by immunofluorescence on day 12, compared with controls (p less than 0.01). @entity35 given 10 mg Heymann antibody and treated on days 1-5 were less frequently positive for rabbit IgG on day 5 than controls (p less than 0.05). When treatment was given on days 6-12 (autologous phase), fewer @entity35 had glomerular @entity95 and rat IgG compared with controls (p less than 0.025). Protease treatment of @entity35 given nephritogenic doses of Heymann antibody (greater than or equal to 40 mg, causing @entity644 ) did not result in significant differences in immunofluorescence deposits. However, protease treatment significantly reduced the number of electron dense deposits at all doses of antibody (p less than 0.01). Furthermore, @entity35 given 60 mg Heymann antibody followed by enzyme treatment in the heterologous phase (days 1-7) or throughout the autologous phase (days 6-18) had significantly reduced protein excretion during the autologous phase compared with control @entity35 (p less than 0.05). After onset of significant @entity644 on day 15 in @entity35 given 40 mg Heymann antibody and treated from day 15 until day 25, there was significantly less (p less than 0.05) @entity644 on days 21-22 and 24-25 than in control @entity35 ; thus, enzymes could reverse @entity644 . In normal @entity35 , administration of proteases did not have significant effects on urinary protein excretion, serum @entity1011 , or renal morphology, nor did protease affect anti-rabbit IgG antibody production in @entity35 injected with Heymann antibody. The overall results indicate that proteolytic enzyme treatment can prevent or remove @entity8 and can prevent or reverse @entity644 .
