Role of uCyt+ in the detection and surveillance of XXXX .

@entity1 @entity5 @entity189 @entity150 @entity18403
OBJECTIVES: To test the clinical value and role of uCyt+ as a noninvasive tool for the detection and surveillance of @entity189 . METHODS: Included in this prospective study were 235 @entity1 (mean age 71.5 years, range 32 to 86). Of these, 98 @entity1 had signs and symptoms suggestive of @entity150 and 137 @entity1 were being followed up after complete transurethral resection of superficial @entity5 ( @entity5 ). All @entity1 underwent urinary cytology and the uCyt+ test performed on ThinPrep (thin layer). All underwent subsequent cystoscopy and evaluation of any suspicious lesion by biopsy. RESULTS: A total of 102 @entity1 had histologically proven @entity5 . In the group of @entity1 with signs and symptoms suspicious of @entity5 , the sensitivity of cytology increased from 5% for G1 to 84.6% for G3 @entity5 ; for uCyt+, it was 85% for G1, 100% for G2, and 92.3% for G3 @entity5 . Combining cytology and uCyt+, the sensitivity was 85% for @entity18403 . In the group of follow-up @entity1 , the sensitivity of cytology increased from 4.3% for G1 to 94.4% for G3 @entity5 ; for uCyt+, it was 78.2% for G1, 70% for G2, and 94.4% for G3 @entity5 . Combining both tests, the sensitivity was 78.2% for G1, 90% for G2, and 100% for G3. CONCLUSIONS: The uCyt+ is a valid test in the detection of @entity5 of all grades and stages. It improves the sensitivity of cytology in low-grade @entity5 . The two tests combined may be a highly sensitive method to detect @entity5 early in detection and surveillance.
