Computed tomographic brain studies and treatment response in XXXX .

@entity1 @entity935 @entity161 @entity76 @entity716 @entity750 @entity67 @entity1063
@entity67 has been described in chronic @entity161 since 1927. The CT Scan has stimulated considerable interest and studies have shown that 50% of chronic schizophrenics and up to 20% of acute schizophrenics have enlarged ventricles. Widening of cortical sulci, @entity76 , third @entity67 and reversed hemispheric asymmetry have also been reported. @entity67 seems to both predate the development of @entity716 and to develop further during the course of the illness. Twin studies indicate that @entity67 may be the result both of genetic vulnerability and of environmental onslaught. The other abnormalities may be secondary. Schizophrenics without @entity67 of a range of @entity935 -related variables. Schizophrenics with @entity67 show some evidence of @entity750 and @entity1063 cell loss. Very few published papers address the issue of treatment response. These seem to demonstrate a relationship between enlargement and poor response to neuroleptic medication. Schizophrenics with very large ventricles may also be particularly sensitive to the adverse effects of neuroleptics. It is not yet clear that the CT Scan may be used to identify @entity1 unlikely to respond to medication. Long term prospective studies are required.
