The effect of pancreatectomy on the uptake of metabolites by the XXXX fetus.

@entity742 @entity26 @entity880 @entity26434 @entity413
The effects of fetal pancreatectomy on the uptake of @entity26 , @entity413 and @entity880 by the fetus, uterus and uteroplacental tissues were investigated in chronically catheterized @entity742 during the last third of gestation. Pancreatectomy reduced the uptake of @entity413 by the fetus but had little apparent effect on @entity413 uptake by the uterus or uteroplacental tissues. The mean umbilical uptake of @entity413 by the pancreatectomized fetuses was 10.4 +/- 1.1 mumol/kg . min (n = 4) which was significantly less than the value observed in the intact fetuses (24.5 +/- 2.7 mumol/kg . min, n = 4, P less than 0.01). When all the data from the pancreatectomized and intact fetuses were combined, there was a significant positive correlation between the plasma @entity26434 concentration in utero and the umbilical uptake of @entity413 (r = 0.95, n = 14, P less than 0.01). The @entity413 / @entity26 quotient in the pancreatectomized fetuses (0.32 +/- 0.02, n = 9) was significantly less than the value observed in the intact fetuses (0.59 +/- 0.04, n = 6, P less than 0.01). There was also a significant positive correlation between the @entity413 / @entity26 quotient and the plasma concentration of @entity26434 in the fetus (r = 0.73, n = 59, P less than 0.01). Pancreatectomy had no significant effect on the fetal @entity880 / @entity26 quotient or on the uptake of @entity26 or @entity880 by any of the tissues. These observations demonstrate that the endogenous concentration of @entity26434 is a physiological regulator of @entity413 uptake by the fetal tissues.
