The Effect of Timing of Concurrent Chemoradiation in XXXX With Newly Diagnosed @entity463 .

@entity1 @entity463 @entity2903 @entity1349
BACKGROUND: The effect of timing of initiation of concurrent radiation and chemotherapy after surgery on outcome of @entity1 with @entity463 ( @entity463 ) remains unclear. OBJECTIVE: To further explore this issue, we analyzed 4 clinical trials for @entity1 newly diagnosed with @entity463 receiving concurrent and adjuvant @entity2903 . METHODS: The cohort study included 198 adult @entity1 with newly diagnosed supratentorial @entity463 who were enrolled from 2004 to 2010 in 4 clinical trials consisting of radiation plus @entity2903 and an experimental agent. The interval to initiation of therapy was determined from the time of surgical resection. The partitioning deletion/substitution/addition algorithm was used to determine the cutoff points for timing of chemoradiation at which there was a significant difference in @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). RESULTS: The median wait time between surgery and initiation of concurrent chemoradiation was 29.5 days (range, 7-56 days). A short delay in chemoradiation administration (at 30-34 days) was predictive of prolonged @entity1349 (hazard ratio [HR]: 0.63, P = .03) and prolonged @entity1349 (HR: 0.68, P = .06) compared with early initiation of concurrent chemoradiation (<30 days), after adjusting for protocol and baseline prognostic variables including extent of resection by multivariate analysis. A longer delay to chemoradiation beyond 34 days was not associated with improved @entity1349 or @entity1349 compared with early initiation (HR: 0.94, P = .77 and HR: 0.91, P = .63, respectively). CONCLUSION: A short delay in the start of concurrent chemoradiation is beyond the classic paradigm of 4 weeks post-resection and may be associated with prolonged @entity1349 and @entity1349 . ABBREVIATIONS: @entity463 , glioblastomaKPS, Karnofsky Performance ScoreOS, overall survivalpartDSA, partitioning deletion/substitution/addition algorithmPFS, progression-free survivalRT, radiation therapyTMZ, @entity2903 .
