[Clinico-histological behavior of celiac XXXX after gluten load following the definitive diagnosis].

@entity1 @entity6122 @entity1593 @entity66 @entity14086
In the last 18 years we have followed 330 @entity1 with @entity66 ( @entity66 ), diagnosed according to the ESPGAN criteria (with 3 jejunal biopsies: during the acute phase, after a gluten-free diet and after a gluten challenge). One to fifteen years after the diagnosis, 61 of them asked to be exposed to a second gluten challenge to see if their intolerance was persistent. Ten percent of them had already started the challenge by themselves, the others were on @entity1593 ( @entity1593 ). To all 61 serial clinical controls, one-hour-blood- @entity6122 absorption test every three months and a jejunal biopsy was suggested. The jejunal biopsy was performed when symptoms recurred, or when xylose-test showed an impaired absorption, or after 2 years. If the first jejunal biopsy showed a villous atrophy the @entity1593 was restarted, while if a normal mucosa was found the gluten challenge was continued and the jejunal biopsy repeated every year. 52 @entity1 (85%) showed a villous atrophy after 1.5 to 72 months. 6 (10%) did not show a clinical or histological relapse, 2 refused the jejunal biopsy because symptomless, and 1 had to restart the @entity1593 because she developed a @entity14086 . One-hour-blood-xylose test was performed in 29 @entity1 and 20 (69%) showed a low absorbtion, the majority of them in the first year of challenge, and the remaining refused it. 36 of the relapsed @entity1 presented with mild clinical symptoms while 16 were symptomless.(ABSTRACT TRUNCATED AT 250 WORDS)
