Largest series of @entity4153 ( XXXX ): The Saskatchewan Experience.

@entity1 @entity19071 @entity4153 @entity66 @entity5 @entity2 @entity189
UNASSIGNED: 9681 Background: : Although @entity4153 has been recognized as a rare and distinct clinicopathologic entity, limited data is available about its clinical behavior and outcome. Our experience with @entity4153 over the @entity19071 decades is presented here. METHODS: @entity1 with @entity4153 were identified using Saskatchewan Cancer Registry - Canada, from 1971-2002. Diagnosis was based on immunohistochemistry and/or morphology. @entity1 with abnormal chest radiology at diagnosis or with well-differentiated @entity5 or Merkel cell @entity189 were excluded. Survival was calculated using the Kaplan-Meier method. RESULTS: A total of 101 eligible @entity1 with @entity4153 were identified. Median age was 72 yrs (24-100) and M:F was 1.4:1. Median duration of symptoms prior to definitive diagnosis was 2 months [m] (0.25-40). 51 @entity1 had localized disease and 50 had @entity66 .No significant difference was noted in age, gender distribution, comorbid illness, and incidence of of secondary @entity5 , however 96% of @entity1 with limited disease (LD) had ECOG performance status of <= 2 compared with 52% in @entity66 ( @entity66 ) [p=<0.0001]. The primary disease sites were as follows: Breast n=9; gastrointestinal n=20, genitourinary n=18, gynecologic n=11, head _ neck n=10, thymus n=2, and unknown primary n=31 . Ninety percent of @entity1 with LD received treatment and 98% of them had an objective response (OR). In contrast, 54% @entity1 with @entity66 received therapy and 44% of them had OR(p<0.0001). Median progression/relapse free survival in responding @entity1 with LD was 20+ m (2-276) compared with 12+ m (2-68) in @entity66 (p<0.0001). All the @entity1 with LD had median OS of 34+ m (0.2-276) compared with 2+ m (0.1-108) in @entity1 with @entity66 (p<0.0001). 5 year survival in @entity1 with LD was 31% compared with 2% in @entity1 with @entity66 . CONCLUSIONS: Our results reveal that natural history of @entity4153 seems comparable to small cell @entity2 and that extent of disease is an important factor predicting survival. No significant financial relationships to disclose.
