The efficacy of intratumoural @entity1487 for the treatment of XXXX sarcoids.

@entity5 @entity1641 @entity15382 @entity1487
OBJECTIVE: To document the efficacy of intratumoural injections of @entity1487 for the treatment of @entity1641 sarcoids. DESIGN: A prospective study that included 13 @entity1641 and one @entity15382 . PROCEDURE: Sarcoids were confirmed by histological examination and treated with intratumoural @entity1487 every 2 weeks. If the sarcoids did not resolve after seven treatments, treatment was considered a failure. All cases were re-examined 6 months after treatment commenced and owners were telephoned 3 years after commencement of treatment to report on @entity5 recurrence. Outcome comparisons were performed to determine the effect of previous treatment, @entity5 size and @entity5 location on sarcoid resolution. The efficacy of intratumoural @entity1487 was compared with other previously documented treatments of @entity1641 sarcoids. RESULTS: Sarcoids smaller than 13.5 cm3 were significantly (P = 0.032) more likely to resolve with treatment than larger sarcoids. Sarcoids that were not responsive to previous therapies were significantly (P = 0.007) more likely to recur after 3 years than sarcoids that had not been treated prior to this study. In this study, there were similar rates of resolution in cases with @entity5 (66.6%) when compared to cases with single @entity5 (60%). The numbers in this study were too small to properly evaluate the effect of @entity5 location on the success of treatment. Intratumoural @entity1487 appeared to have resolved sarcoids in 9 of 13 cases (61.5%) as determined by follow up conversation with the owners 3 years after the initial treatment. CONCLUSION: The use of intratumoural @entity1487 compares favourably with other treatment modalities for sarcoids, with a long term successful resolution rate of 61.5%. Owners should be warned that resistant sarcoids and sarcoids larger than 13.5 cm3 have a poorer prognosis for resolution and more aggressive therapeutic options should be considered.
