XXXX perspective on herpes zoster and its complications: an observational prospective study in @entity1 aged over 50 years in general practice.

@entity1 @entity308 @entity697 @entity1109 @entity158 @entity14000 @entity9
Understanding the effect of herpes zoster and zoster-related @entity158 should inform care to improve health-related quality of life in elderly @entity1 . A 12-month, longitudinal, prospective, multicenter observational study conducted in primary care in France enrolled @entity1 aged >=  50 years with @entity697 . @entity1 -reported zoster-related @entity158 was assessed by validated questionnaires (Douleur Neuropathique en 4 Questions [DN4], Zoster Brief @entity158 Inventory [ZBPI], and @entity9 Symptom Inventory [NPSI]) on days 0 and 15, and at months 1, 3, 6, 9, and 12. Health-related quality of life was assessed by the 12-item short-form health survey (SF-12) and the Hospital Anxiety and @entity308 scale on day 0 and at months 3, 6, and 12. Of 1358 @entity1 included, 1032 completed follow-up. Mean    standard deviation age was 67.7    10.7 (range, 50-95) years; 62.2% were @entity1 . Most @entity1 (94.1%) were prescribed antiviral drugs. The prevalence of zoster-related @entity158 on day 0 and at months 3, 6, 9, and 12 was 79.6%, 11.6%, 8.5%, 7.4%, and 6.0%, respectively. @entity1 with persistent @entity158 had lower scores on the physical and mental component summaries of the SF-12 and the ZBPI interference score than those without @entity158 . By logistic regression analysis, main predictive factors on day 0 for @entity14000 at month 3 were age, male sex, ZBPI interference score, Physical Component Summary score of the SF-12, and @entity1109 of @entity158 (DN4 score >=  4). Despite early diagnosis and treatment with antiviral agents, many @entity1 with herpes zoster experience persistent @entity158 and marked long-term reduction in health-related quality of life.
