Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of @entity8 in XXXX .

@entity8 @entity455 @entity23032 @entity6 @entity2316 @entity532 @entity1723 @entity989
Elevated levels of advanced glycosylation end products (AGEs) have been found in multiple tissues in association with @entity532 and during the microalbuminuric phase of @entity2316 . In this study, we have used an AGE-specific enzyme-linked immunosorbent assay (ELISA) to measure skin AGEs to determine whether elevated levels can be detected before the onset of @entity455 . Subjects with @entity1723 (n = 48) were graded for the degree of @entity8 (normal [23], microalbuminuria [12], or macroalbuminuria [12]) and @entity989 (none [13], background [20], or proliferative [15]). Subgroups with a premicroalbuminuric phase of albumin excretion (< or = 28 mg/24 h, n = 27) or with the earliest stages of @entity989 (n = 27) were identified. A significant increase in tissue AGEs was found as urinary albumin increased during the premicroalbuminuric phase of @entity8 even when the data were adjusted for age and duration of @entity6 (P = 0.005). Immunoreactive AGEs also increased as normal renal status advanced to microalbuminuria and macroalbuminuria (P = 0.0001 across groups). Significant elevation of AGEs was also found in association with the earliest stages of clinically evident @entity989 (early background versus minimal grades). In addition, higher AGE levels were found in subjects with @entity989 when compared with those with less severe @entity989 (P < 0.004 across groups). In contrast, no significant differences were found in tissue AGE levels between groups with or without early @entity989 based on @entity23032 or fluorescent AGE measurements, although fluorescent AGEs correlated with albumin excretion.(ABSTRACT TRUNCATED AT 250 WORDS)
