Higher serum total @entity648 concentration is associated with lower risk of XXXX in an adult population.

@entity1 @entity32 @entity1009 @entity648 @entity409 @entity740 @entity177
BACKGROUND: @entity32 is proposed to play a central role in the pathogenesis of @entity740 ( @entity740 ), and serum @entity648 has antioxidant and anti-inflammatory effects. We investigated the association between serum total @entity648 (Tb) concentration and renal function in an adult population. METHODS: We conducted a cross-sectional study and collected anthropometric measurements, fasting blood tests, lifestyle habits and medical history of 3876 subjects attending a health examination. @entity177 was defined as estimated glomerular filtration rate (eGFR) <60 mL/ @entity1009 .73 m(2) calculated by using the @entity740 -EPI equation. RESULTS: Serum Tb concentrations were higher in subjects without @entity177 than in those with @entity177 . Multivariable linear regression analysis showed that Tb concentration was positively associated with eGFR after adjusting for important @entity740 risk factors (P=0.04). Multivariable logistic regression analysis also revealed that higher Tb concentration (each increment of 1.71  mol/L) (0.1 mg/dL) was associated with a reduced risk of @entity177 : odds ratios were 0.94 (P=0.005) for @entity1 and 0.90 (P=0.015) for @entity1 , respectively. When subjects were divided into quartiles of serum Tb, multivariable-adjusted odds ratios for @entity177 comparing the fourth to the first Tb quartile were 0.49 (P=0.001) for @entity1 and 0.35 (P=0.003) for @entity1 . A stepwise exclusion of subjects, first those with possible @entity409 and second, those with @entity740 stage 4 and 5, showed consistent results. CONCLUSION: Higher serum Tb concentration was associated with lower risk of @entity177 , regardless of other conventional @entity740 risk factors.
