Aggressive treatment is appropriate for @entity463 XXXX 70 years old or older: a retrospective review of 206 cases.

@entity1 @entity463 @entity66 @entity1349
Elderly @entity1 have largely been excluded from randomized trials for @entity463 ( @entity463 ). We reviewed the results of treatment approaches, which included surgery, chemotherapy, and radiation in this group of @entity1 . @entity1 were treated during the period 1979-2007 and were 70 years of age and older with histologically confirmed @entity463 . @entity1349 ( @entity1349 ) was the primary endpoint of this retrospective study. Two hundred six @entity1 70 years of age and older were identified. Median age was 75 years (range 70-90). Median @entity1349 time was 4.5 months. Univariate analysis showed that @entity1349 was significantly impacted by KPS score (1.8 months for KPS  <= 50 to 17.2 months for KPS >=  90, P < .001), age at diagnosis (5.1 months for age 70-79 versus 3.1 months for age >=  80, P < .001), and extent of disease (worse for bilateral disease [P = .003], multifocal disease [P = .005], and @entity66 [P = .02]). On multivariate analysis, higher KPS score (P = .006), surgical resection (any surgery beyond biopsy) (P < .001), radiation therapy (P < .001), and chemotherapy (P < .001) were all found to be independently associated with improved @entity1349 . In this study of newly diagnosed @entity463 @entity1 over the age of 70 years, aggressive treatment with radiation, chemotherapy, and surgery is associated with @entity1349 .
