Gender Differences in Regional Brain Activity in XXXX with @entity22 : Evidence from a Resting-State fMRI Study.

@entity1 @entity25 @entity4365 @entity22
OBJECTIVE: To explore the regional brain activities in @entity1 with chronic @entity22 (PCPIs) and their sex differences. METHODS: Forty-two PCPIs (27 females, 15 males) and 42 @entity25 ( @entity25 ; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. @entity4365 ( @entity4365 ) method was used to assess the local brain features. The mean signal values of the different @entity4365 areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. RESULTS: Both female and male PCPIs showed higher @entity4365 in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower @entity4365 in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower @entity4365 in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher @entity4365 in the bilateral middle temporal gyrus and lower @entity4365 in the left limbic lobe. The different areas showed high test-retest stability (Clusters of contiguous volumes >= 1080 mm3 with an intraclass correlation coefficient >= 0.80) and high degree of sensitivity and specificity. CONCLUSIONS: Female PCPIs showed more regional brain differences with higher and lower @entity4365 responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas.
