Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe XXXX .

@entity1 @entity4314 @entity409 @entity1578 @entity35 @entity99
AIM: To investigate the therapeutic effect of umbilical cord blood transplantation (UCBT) on @entity1 with severe @entity409 in @entity35 . METHODS: One hundred and fifty three @entity1 with severe @entity99 were included in the study between April 1990 and July 2002. The @entity1 were treated with adult plasma transfusion (control), UCBT, plasma exchange (PE) and UCBT combined with PE (UCBT+PE) respectively. The therapeutic effectiveness was evaluated by serial determinations of liver function, lipids and immune function in all @entity1 before and after the treatment. The model of experimental @entity1578 was constructed in SD @entity35 by injecting @entity4314 . Then, the @entity35 were given normal saline, adult plasma or neonate cord blood intraperitoneally. After detection of liver function, the @entity35 were killed and morphological changes of the liver were microscopically observed. RESULTS: UCBT group and UCBT+PE group had much better improvement in liver and immune functions than control group and PE group. The @entity1 in UCBT+PE group had the best clinical efficacy. UCBT was safe and had no side effects. The animal experiment showed significant improvements in liver function and survival rate in neonate cord blood group as compared with adult plasma group. The histopathology of @entity35 's liver indicated that neonate cord blood application could decrease the @entity99 and increase hepatocellular regeneration. CONCLUSION: UCBT demonstrated a good therapeutic effect on severe @entity99 and no obvious side effects. Umbilical cord blood can attenuate the @entity409 and reproduce hepatocyte. The treatment of UCBT combined with PE was much better than that of single plasma exchange, thus UCBT can enhance the therapeutic effect of plasma exchange on severe @entity99 .
