Non-invasive vessel examinations in carriers of LDL-receptor defective gene versus non-carriers with newly detected asymptomatic severe XXXX .

@entity1 @entity4631 @entity753 @entity1007 @entity72727 @entity755 @entity1675 @entity121 @entity165
The results of the research of early vascular alterations in LDL-R carriers in comparison with those in non-carriers with severe @entity1007 are controversial. AIM: To investigate the difference between severe @entity1007 @entity1 that carry LDL-R defective gene and those that do not have it, in their functional (flow-mediated vasodilation) and structural ( @entity121 of carotid artery and ankle-brachial index) characteristics of arterial wall. @entity1 AND METHODS: The study included 120 @entity753 @entity1 . Biochemistry parameters were studied by routine methods. The flow-mediated vasodilation (% @entity4631 ), ankle-brachial index (ABI) and @entity121 ( @entity121 ) of common carotid artery were determined using Hewlett Packard Sonos 5 500; MedicaSoft. @entity121 .lab was the software programme used in the study. RESULTS: There was no significant difference between the groups with respect to total @entity165 , LDL, HDL, @entity755 , @entity1675 , cellular adhesion molecules (sICAM-1, sVCAM-1, sP- and sE- @entity72727 ). The @entity755 / @entity1675 index differed significantly (t = 11.23, p < 0.001) between the two groups; there was difference even after adjustment for age. There was no significant difference in the endothelial dependent and independent vasodilatation between the examined groups (p > 0.05). We found a significantly greater carotid @entity121 and lower ABI in the carriers than the respective parameters in the non-carriers. This significant difference was confirmed after adjustment for age. CONCLUSION: Our data show that LDL-R carriers have a higher carotid @entity121 and lower ABI than non-carriers, whereas no difference between the groups was found with respect to the level of lipid parameters and % @entity4631 .
