Correlation between HRCT findings, pulmonary function tests and bronchoalveolar lavage cytology in @entity401 associated with XXXX .

@entity1 @entity286 @entity55 @entity75 @entity401 @entity70908 @entity309
A prospective study correlating high-resolution computed tomography (HRCT), lung function tests (PFT) and bronchoalveolar lavage ( @entity70908 ) cytology in @entity1 with @entity401 ( @entity401 ) associated with @entity309 ( @entity309 ). Fifty-three @entity309 @entity1 with suspected @entity401 (19 @entity1 , 34 @entity1 ) underwent 71 HRCT (14 of 53 with sequential HRCT, mean follow-up 24.3 months). The HRCT evaluation by two observers on consensus included a semi-quantitative characterisation of lesion pattern and profusion on representative anatomical levels. Fifty-two HRCT were followed by PFT and @entity70908 . Agreement or discordance of HRCT-, @entity70908 findings were analysed with Pearson's correlation, kappa score and McNemar's test. @entity286 -fume exposure was estimated in pack years. Smoking/non-smoking groups were compared with Student's t test. In 49 of 53 @entity1 , HRCT was suggestive of @entity401 associated with @entity309 (66 of 71 HRCT). @entity75 were found in 40 of 53 @entity1 , in 15 of 40 presenting as mixed pattern with ground-glass opacities (GGO). Pure reticular patterns predominated in @entity1 with long duration of @entity401 (p>0.01). Pure GGO were not observed. Lesion profusion was highly variable and correlated moderately negative with diffusion capacity (mean 88.2% (SD +/- 20.9%); r=-0.54; p<0.001) and very weak with vital capacity and FEV1 (mean values 92.2% (SD +/- 18.3%); r=-0.27; p<0.05 and 89.8% (SD +/- 17.5%); r=-0.31; p<0.01). In @entity1 with GGO, @entity70908 differentials tended towards neutrophilia (kappa=0.39; p=0.04; McNemar test p>0.2), but not towards lymphocytosis (kappa=0.10; p=0.23; McNemar test p>0.2). Differences in smoking history were not significant (p>0.1). The HRCT appears most appropriate for the detection and follow-up of @entity401 associated with @entity309 . The PFT and @entity70908 correlate only partially with lesion profusion or grading on HRCT, but they contribute valuable information about dynamic lung function and differential diagnoses ( @entity55 , medication side effects).
