Assessment of the methodologic quality of medical and surgical clinical trials in XXXX with arthroplasty.

@entity1 @entity302 @entity942
OBJECTIVE: To assess the methodological quality of randomized controlled trials ( @entity302 ) of medical and surgical therapy in @entity1 with arthroplasty. METHODS: We conducted a Medline database search for all arthroplasty @entity302 from 1997 and 2006. The quality of the methods of all eligible @entity302 was assessed by a trained abstractor. We used a checklist of trial quality characteristics, and the overall trial quality was assessed by 3 scales: Jadad (range 0-5), Delphi list (range 0-9), and numeric rating scale (NRS; range 1-10), based on User's Guides to the Medical Literature. RESULTS: A total of 196 articles were included in the analysis; most included hip (n = 81) or knee (n = 80) or both hip/knee arthroplasty (n = 19); 66 (34%) assessed pharmacological treatments, 117 (60%) nonpharmacological treatments, and 13 (7%) both. Mean (SEM) overall quality scores of arthroplasty @entity302 were low: Jadad score 2.36 (1.4), Delphi list 5.33 (1.6), and NRS score 4.30 (2.6). Multivariable analyses revealed that nonpharmacological intervention @entity302 had lower odds (odds ratio 0.28-0.39; p = 0.008-0.033) and those with no funding had lower odds (OR 0.28-0.50; p = 0.014-0.119) of being in the highest quartiles of the 3 overall quality scores. In contrast, multicenter @entity302 had 1.8-4.7 times higher odds of being in highest tertiles of quality scores (p = 0.017-0.185). CONCLUSION: @entity942 in reporting of hip/knee arthroplasty @entity302 offer an opportunity for improvement. Type of intervention, number of trial centers, and presence of funding were independently associated with overall trial quality. In future, multicenter @entity302 ( @entity302 ) and modeling protocols of single-center @entity302 similar in rigor to multicenter @entity302 may improve the quality of arthroplasty @entity302 .
