Computer-assisted XXXX dosage adjustment.

@entity1 @entity2690 @entity413 @entity6
We report our first experience with a new microprocessor device for assisting individuals with @entity6 in the adjustment of @entity2690 therapy. The computer weighs 200 g and can receive, store, and analyze @entity1 -entered capillary blood @entity413 (CBG) data on an ongoing basis. Changes in the injected mixtures of short- and intermediate-acting insulins are recommended according to algorithms designed to bring the premeal CBG levels to any desired target value set by the physician. Throughout the present study, the premeal target @entity413 level was set to 110 mg/dl. Seven (type I) @entity2690 -dependent @entity6 individuals ranging in age from 11 to 43 yr were selected to participate in the first use of a BCMC (Better Control Medical Computers, Inc., Toronto, Ontario, Canada) computer on an outpatient basis. All subjects were concerned about @entity6 control and were fully informed about as well as thoroughly practiced in the use of manual @entity2690 dosage adjustment schemes, based on approximately equal to 4 times daily CBG estimation, as currently taught in our @entity6 clinics. During the last 7 days of the control period of self-adjustment, their mean +/- SEM CBG levels (measured before breakfast, lunch, dinner, and bedtime snack) were, respectively, 178 +/- 20, 187 +/- 35, 208 +/- 22, and 207 +/- 13 mg/dl. Immediately after the control period they were given the device and were instructed in the procedure for entering glycemic data and following manufacturer's recommendations in regard to @entity2690 dosages. This experimental period lasted 8 wk and the outcome was assessed as before. Thus, 8 wk after starting daily use of the instrument, all glycemic values measured as before had fallen significantly (P less than 0.005-0.05) closer to normal: 116 +/- 9, 110 +/- 6, 148 +/- 15, and 135 +/- 9 mg/dl, respectively. Concurrently there was also a significant (P less than 0.01) reduction in the variability of glycemia measured before the main meals.(ABSTRACT TRUNCATED AT 250 WORDS)
