Evaluating the safety and efficacy of XXXX -restricted/Dietary Approaches to Stop @entity101 diet after acute decompensated @entity712 hospitalization: design and rationale for the Geriatric OUt of hospital Randomized MEal Trial in @entity712 (GOURMET- @entity712 ).

@entity1 @entity712 @entity697 @entity101 @entity296 @entity1372 @entity177 @entity551 @entity65 @entity4144
BACKGROUND: @entity712 ( @entity712 ) is a major public health problem affecting predominantly older adults. Nonadherence to diet remains a significant contributor to @entity712 ( @entity697 ). The @entity1372 -restricted Dietary Approaches to Stop @entity101 (DASH/SRD) eating @entity65 that can lead to @entity697 and is consistent with current @entity712 guidelines. We propose that an intervention that promotes adherence to the DASH/SRD by home-delivering meals will be safe and improve health-related quality of life (QOL) in older adults after hospitalization for @entity697 . METHODS/DESIGN: This is a 3-center, randomized, single-blind, controlled trial of 12-week duration designed to determine the safety and efficacy of home-delivered DASH/SRD-compliant meals in older adults after discharge from @entity697 hospitalization. Sixty-six subjects will be randomized in a 1:1 stratified fashion by gender and left ventricular ejection fraction (<50% vs >= 50%). Study subjects will receive either preprepared, home-delivered DASH/SRD-compliant meals or usual dietary advice for 4weeks after hospital discharge. Investigators will be blinded to group assignment, food diaries, and urinary electrolyte measurements until study completion. The primary efficacy end point is the change in the Kansas @entity296 Questionnaire summary scores for health-related QOL from study enrollment to 4weeks postdischarge. Safety evaluation will focus on @entity551 , @entity177 , and @entity4144 . Exploratory end points include echocardiography, noninvasive vascular testing, markers of oxidative stress, and salt taste sensitivity. CONCLUSION: This randomized controlled trial will test the efficacy, feasibility, and safety of 4weeks of DASH/SRD after @entity697 hospitalization. By testing a novel dietary intervention supported by multiple levels of evidence including preliminary data in outpatients with stable @entity712 , we will address a critical evidence gap in the care of older @entity1 with @entity697 . If effective and safe, this intervention could be scaled to assess effects on readmission and healthcare costs in older adults after @entity697 .
