@entity410 Have Moderate and Transient Effects on Spatial Learning in Immature XXXX .

@entity410 @entity2045 @entity4207 @entity35 @entity221
The aim of this study was to characterize a novel animal model @entity221 -induced @entity410 and to investigate the impacts of repetitive @entity410 on @entity4207 performances in immature @entity35 . Methods. @entity35 were subjected to @entity221 exposure one, two, or three times in 10-day intervals during 30   min in a water bath warmed at 45-50  C and their behaviour was monitored. Morris water maze @entity4207 were examined for control and treated groups. Results showed that @entity35 subjected to 30-minute @entity221 hot water developed rapidly @entity2045 and then generalized @entity410 . After a single @entity221 exposure, the time for generalised @entity410 appearance was 16.08    0.60   min and it decreased gradually with repetitive exposure to reach 12.46    0.39   min by the third exposure. @entity410 altered the @entity4207 abilities in Morris water maze and increased the time spent to attain the platform after one or two exposures, while after a third exposure @entity35 exhibited the same latency compared to controls. Similar results were obtained in probe test where @entity35 , subjected to @entity221 for one or two episodes, spent less time in the target quadrant compared to corresponding controls. Further, when platform was moved from northwest to southwest quadrant, memory transfer test indicated that after one or two @entity221 exposures cognitive performances were slightly altered, while after a third exposure the latency to escape increased significantly compared to untreated group. It was concluded that 30   min of @entity221 hot water was sufficient to induce @entity410 in immature @entity35 and an increase of susceptibility was observed with repetitive @entity221 exposure. @entity221 treatment impaired cognitive performances but the effects were mostly transient and moderate.
