A randomised comparison of regular oral XXXX and intrathecal @entity1286 for post-caesarean analgesia.

@entity1 @entity1288 @entity3522 @entity111 @entity1286 @entity158 @entity1443 @entity282
BACKGROUND: Primary post-caesarean analgesia based on oral opioid has not been adequately studied. This approach may show a good side-effect profile and high satisfaction and avoid neuraxial complications. METHODS: In a double-blind, double-dummy, placebo-controlled clinical trial 120 @entity1 were randomised to receive either sustained-release oral @entity1288 20mg in the recovery room followed by immediate-release @entity1288 10mg 6-hourly for the first 24h (group O) or intrathecal @entity1286 100mug at the time of spinal anaesthesia (group I). All @entity1 received regular postoperative @entity3522 , @entity1443 and standardised supplemental analgesia. RESULTS: One hundred and eleven @entity1 completed the study. The area under the curve for @entity158 scores to 24h did not differ significantly between groups for @entity158 at rest (P=0.465) or on movement (P=0.533). Numerical @entity158 scores were low and similar, except at rest at 12h (group I 1 [0-2] vs. group O 2 [1-3]; P=0.030). The time to first analgesic request was similar but additional postoperative analgesics were required more often in group O (82% vs. 63%, P=0.034). Group O more frequently reported high worst @entity158 scores (score 4-10 in 87% vs. 64%, P=0.007). @entity111 was more common and more severe in group I (87% vs. 56%, P=0.001). At 24h maternal satisfaction with the analgesic regimen was lower in group O (P=0.010). CONCLUSION: Oral @entity1288 produced comparable @entity282 relief to intrathecal @entity1286 with a lower incidence of @entity111 , but was associated with a lower satisfaction score.
