[A case of mixed XXXX of the transverse colon].

@entity1 @entity4181 @entity901 @entity5 @entity694 @entity189 @entity1358 @entity490 @entity1142 @entity420 @entity3270 @entity1487
A 7 1-year-old @entity1 presented to our hospital with @entity1142 and @entity490 . Computed tomography of the abdomen and colonoscopy revealed @entity5 of the transverse colon. The biopsy specimen indicated a highly differentiated @entity420 . The @entity1 underwent extended right hemicolectomy with regional lymph node dissection. Pathological examination showed a @entity3270 (NEC)with concurrent @entity694 and regional lymph node metastases of the NEC and @entity420 . The histopathological examination confirmed a diagnosis of mixed @entity189 (MANEC)in accordance with the 2010WHO Classification of Tumors of the Digestive System. Liver and lung metastases were identified 8 months after the surgery. We administered chemotherapy including @entity1487 , @entity4181 , and @entity901 (mFOLFOX)plus bevacizumab, with limited therapeutic effect, as the disease progressed despite treatment. The @entity1 chose best supportive care 13 months after the surgery. Several studies have reported that most @entity1 with @entity1358 , including MANEC, experience relapse within 1 year after surgery, and few @entity1 remain disease-free for long periods after surgery. The optimal strategy for the management of MANEC is variable owing to its rarity; only 2 cases of MANEC in the colon, including the present case, have been reported in Japan. It is thus important to gather more evidence on this disease and its management.
