Bioassay of XXXX for possible carcinogenicity.

@entity19727 @entity19 @entity5 @entity35
A bioassay of @entity19727 for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer 344 @entity35 and B6C3F1 @entity19 . Groups of 35 @entity35 and 35 @entity19 of each sex were administered @entity19727 at one of the following doses, either 15,000 or 30,000 ppm for the @entity35 , and either 25,000 or 50,000 ppm for the @entity19 , 5 days per week for 78 weeks, then observed for an additional 26-27 weeks. Matched controls consisted of groups of 15 @entity35 and 15 @entity19 of each sex; pooled controls, used for statistical evaluation, consisted of the matched controls combined with 15 untreated male and 15 untreated female animals of each species from a similar bioassay of another test chemical Except for the matched-control male @entity19 , all surviving animals in the study were killed at 104-106 weeks. Half of the matched-control male @entity19 , which were accidentally killed at week 12, were excluded from the report; the remaining matched-control males died by week 94. Mean body weights of the low-and high-dose male and high-dose female @entity35 were lower than those of the corresponding matched controls for the duration of the study. The weights of the low-dose females were similar to those of the matched controls for the first 45 weeks, after which they declined slightly. The weights of the low-dose male @entity19 were similar to those of the matched controls, while those of the high-dose males and of the low-and high-dose females were slightly lower. Survival of both treated and matched-control groups of @entity35 of both sexes was high; survival of treated @entity19 of both sexes and of female matched controls, although lower than that of the @entity35 , was sufficient for meaningful statistical analyses of the incidences of @entity5 . In @entity35 , a variety of @entity5 were observed in both treated and control animals. Few @entity5 were found, and no @entity5 occurred in treated animals in statistically significant incidences when compared with control animals. In @entity19 , a variety of @entity5 were observed in both treated and control animals. These @entity5 are not uncommon in this strain of @entity19 , and none occurred in treated animals in statistically significant incidences when compared with control animals. It is concluded that under the conditions of this bioassay, @entity19727 was not carcinogenic for either Fischer 344 @entity35 or B6C3F1 @entity19 .
