Effect of Morus alba L. (mulberry) leaves on anxiety in XXXX .

@entity19 @entity3175 @entity33336
OBJECTIVE: The aim of the present work is to evaluate the anxiolytic effect of a methanolic extract of Morus alba L. leaves in @entity19 . MATERIALS AND METHODS: The hole-board test, elevated plus-maze paradigm, open field test, and light/dark paradigm were used to assess the anxiolytic activity of the methanolic extract of @entity33336 L. Morus alba extract (50, 100, and 200 mg/kg, i.p.) and @entity3175 (1 mg/kg, i.p.) were administered 30 min before the tests. RESULTS: The results showed that the methanolic extract of @entity33336 significantly increased the number and duration of head poking in the hole-board test. In the elevated plus-maze, the extract significantly increased the exploration of the open arm in similar way to that of @entity3175 . At a dose of 200 mg/kg i.p. the extract significantly increased both the time spent in and the entries into the open arm by @entity19 . Further, in the open field test, the extract significantly increased rearing, assisted rearing, and number of squares traversed, all of which are demonstrations of exploratory behavior. In the light/dark paradigm, the extract produced significant increase in time spent in the lighted box as compared to vehicle. The spontaneous locomotor activity count, measured using an actophotometer, was significantly decreased in animals pretreated with @entity33336 extract, indicating a remarkable sedative effect of the plant. CONCLUSION: The results of the present study suggest that a methanolic extract of @entity33336 leaves may possess an anxiolytic effect.
