Increased cellular activity in XXXX insular cortex after water and salt ingestion induced by fluid depletion.

@entity1219 @entity3371 @entity1483 @entity1372 @entity5019 @entity35
Insular cortex (IC) receives inputs from multiple sensory systems, including taste, and from receptors that monitor body electrolyte and fluid balance and blood pressure. This work analyzed metabolic activity of IC cells after water and @entity1372 ingestion induced by @entity1372 depletion. @entity35 were injected with the diuretic @entity1483 (10 mg/kg body wt), followed 5 min later by injections of the angiotensin-converting enzyme inhibitor @entity3371 (5 mg/kg body wt). After 90 min, some @entity35 received water and 0.3 M @entity1219 to drink for 2 h while others did not. A third group had access to water and saline but was not depleted of fluids. All @entity35 were killed for processing of brain tissue for @entity5019 -immunoreactivity ( @entity5019 -ir). Nondepleted animals had weak-to-moderate levels of @entity5019 -ir within subregions of IC. Fluid-depleted @entity35 without fluid access had significantly increased @entity5019 -ir in all areas of IC. Levels of @entity5019 -ir were highest in fluid-depleted @entity35 that drank water and @entity1372 . @entity5019 -ir levels were highest in anterior regions of IC and lowest in posterior regions of IC. These results implicate visceral, taste, and/or postingestional factors in the increased metabolic activity of cells in IC.
