The Pivotal Role of a Novel Biomarker of Reactive XXXX Species in @entity740 .

@entity1 @entity644 @entity17978 @entity26 @entity740 @entity453 @entity3257 @entity65
UNASSIGNED: Risk stratification of @entity740 ( @entity3257 ) is clinically important because such @entity1 are at high risk of @entity65 . Although reactive @entity26 species (ROS) are reported to be closely associated with the pathophysiology of @entity3257 , there are few useful ROS biomarkers known for @entity3257 @entity1 . Hence, our objectives in this study were to investigate whether serum derivatives of reactive @entity26 metabolites (DROM), a novel biomarker of ROS, is involved in the pathophysiology of @entity3257 (case-control study), and is a significant predictor of future @entity65 in @entity3257 @entity1 (follow-up study). @entity1 with suspected @entity453 ( @entity453 ) were enrolled and underwent coronary angiography. @entity1 with @entity3257 (estimated glomerular filtration ratio <60mL/min/1.73mand/or @entity644 , n=324) were compared with those without @entity3257 ( @entity3257 ). Serum DROM was measured at stable conditions. A case-control study of the 324 @entity3257 @entity1 and 263 @entity3257 @entity1 was conducted after matching risk factors, and a follow-up study of the 324 @entity3257 @entity1 was performed. @entity3257 @entity1 were divided into low- and high-DROM groups using their median value (348 unit; called the Carratelli unit [U. @entity17978 ]), and followed until the occurrence of @entity65 .DROM levels were significantly higher in risk factors-matched @entity3257 @entity1 than in risk factors-matched @entity3257 @entity1 (347.0 [301.8-391.8] U. @entity17978 vs. 338.5 [299.8-384.3] U. @entity17978 , P=0.03). During mean 23  14 months follow-up of 324 @entity3257 @entity1 , 83 @entity65 were recorded. Kaplan-Meier analysis demonstrated a higher probability of @entity65 in @entity3257 @entity1 with high DROM than in those with low DROM (P<0.001, log-rank test). Multivariate Cox hazard analysis including significant predictors in simple Cox hazard analysis demonstrated that high DROM was a significant and independent predictor of @entity65 in @entity3257 @entity1 (hazard ratio: 1.76, 95% confidence interval: 1.10-2.82, P=0.02).In conclusion, serum DROM values were significant and independent predictors of @entity65 in @entity3257 @entity1 , indicating that the measurements of DROM might provide clinical benefits for risk stratification of @entity3257 @entity1 .
