[Influence of hemodialysis on expression of glycoprotein lb platelets reactivity in XXXX with the @entity454 ].

@entity1 @entity308 @entity556 @entity548 @entity740 @entity8729 @entity842 @entity12870 @entity454
Complex disturbances in hemostasis characterise @entity740 . Defect of primary hemostasis is a common cause of @entity548 complications. The @entity12870 ( @entity12870 ), by itself, influences platelet function (the key part of primary hemostasis) which is compromised after the procedure. Many functional defects of thrombocytes have been described in @entity454 ( @entity454 ) @entity1 ; one of them is adhesion defect where the pivotal role plays the complex of glycoprotein Ib (GP Ib) and IX. The aim of the study was to determine the extent of activation, reactivity of platelets and expression of GP Ib in @entity454 @entity1 . The flow cytometry method was used, and @entity556 was used for stimulation of thrombocytes. Membrane expression of GP Ib and @entity8729 was assessed in 14 hemodialysed @entity1 before and after stimulation with @entity556 , before and after @entity12870 and in 10 healthy @entity1 . The @entity1 group had lower expression of GP Ib on resting platelets and significantly lower expression of @entity8729 after stimulation with @entity556 when compared to the control group. After @entity12870 , thrombocytes had much lower expression of GP Ib; however there was no difference in expression of @entity8729 when compared to the state before @entity12870 . A lower reduction of GP Ib expression after stimulation with @entity556 was observed after and before @entity12870 . On the basis of the results the following conclusions may be drawn: hemo-dialysed @entity454 @entity1 have lower expression of platelet GP Ib and reactivity of thrombocytes; the @entity12870 results in further @entity308 in expression of GP Ib and reactivity of thrombocytes. It is plausible that @entity842 (NO) released during @entity12870 modulates the expression of @entity8729 , but it remains to be confirmed.
