Serum concentration of type IV collagen 7S domain as a marker for increased risk of recurrence after liver resection for XXXX .

@entity1 @entity157 @entity82
BACKGROUND/AIMS: Serum concentration of type IV collagen 7S domain (7S collagen) is a marker of hepatic @entity82 . We investigated the usefulness of measuring the serum 7S collagen concentration as a risk factor for recurrence after liver resection for @entity157 ( @entity157 ). METHODS: The serum 7S collagen concentration was measured before liver resection for @entity157 in 219 @entity1 . Group 1 included 102 @entity1 with a high serum concentration of 7S collagen (>or=8.0 ng/ml), and group 2 consisted of 117 @entity1 with a low serum concentration of 7S collagen (<8.0 ng/ml). Clinicopathologic findings and outcome after surgery were compared between groups. RESULTS: The results of liver function tests were better in group 2 than in group 1. The percentage of @entity1 with @entity82 or who underwent minor resection was higher in group 1 than in group 2. The percentage of @entity1 with moderately or poorly differentiated @entity157 or portal invasion was higher in group 2 than in group 1. Univariate and multivariate analyses identified that a high serum concentration of 7S collagen (>or=8.0 ng/ml) was an independent risk factor for recurrence. CONCLUSION: Measuring the serum 7S collagen concentration is useful to estimate the risk of recurrence after resection of @entity157 .
