Sequential treatment with @entity460 alginate dressings and @entity15850 dressings accelerates pressure @entity1066 in older subjects: a multicenter randomized trial of sequential versus nonsequential treatment with XXXX dressings alone.

@entity1 @entity15850 @entity1066 @entity460 @entity446
OBJECTIVES: To compare the efficacy of a sequential strategy combining @entity460 alginate and @entity15850 dressings treatment of grade III or IV pressure ulcers (PUs) and the efficacy of nonsequential strategy with @entity15850 alone. DESIGN: An open, randomized, multicenter parallel-group trial. SETTING: Twenty geriatrics hospital wards. @entity1 : One hundred ten older @entity1 with grade III or IV PUs. INTERVENTION: The control strategy consisted of applying @entity15850 dressings (DuodermE) for 8 weeks; the sequential strategy consisted of applying combined @entity460 alginate dressings (UrgoSorb) for the first 4 weeks and @entity15850 dressings (Algoplaque) for the next 4 weeks. MEASUREMENTS: PU surface areas were measured weekly by @entity1066 tracing. The endpoints were the mean absolute surface area reduction (SAR) during the 8-week study period and the number of @entity1 achieving a 40 or more SAR (SAR40). RESULTS: Fifty-seven and 53 @entity1 were randomly allocated to sequential and control strategies respectively. Baseline @entity1 characteristics and PU @entity1066 features at inclusion were similar in the two groups. Mean +/- standard deviation SAR was significantly larger in the sequential treatment group (5.4 +/- 5.7 cm2 and 7.6 +/- 7.1 cm2 at 4 and 8 weeks) than in the control group (1.6 +/- 4.9 cm2 and 3.1 +/- 7.2 cm2, P< .001). In the sequential treatment group, 68.4 of the @entity1 reached SAR40 at 4 weeks and 75.4 at 8 weeks, proportions significantly larger than in the control group (22.6 and 58.5, respectively, P< .0001). Dressing tolerance was good in both strategies. CONCLUSIONS: In grade III or IV PUs, treatment using first @entity460 alginate dressings and then @entity15850 dressings promotes @entity446 than treatment with @entity15850 dressings alone.
