Surgery followed by radiotherapy for the treatment of metastatic epidural @entity1745 from XXXX .

@entity1 @entity0 @entity66 @entity5 @entity51 @entity615 @entity1745 @entity158 @entity204
STUDY DESIGN: Retrospective analysis of @entity0 @entity1 with metastatic epidural @entity1745 (MESCC) undergoing surgery and radiation therapy. OBJECTIVE: To assess feasibility and clinical outcome of multidisciplinary approach in @entity0 @entity1 with MESCC. SUMMARY OF BACKGROUND DATA: Studies so far published in the setting of surgery and/or radiotherapy in the management of MESCC usually included many @entity5 , without considering the different primary histology. However, when looking at prognostic variables of this therapy, histological type comes out as a major determinant of outcome. METHODS: Twenty-three @entity1 with symptomatic MESCC from @entity0 treated between January 2004 and April 2009 were included in this analysis. Twenty-six surgical procedures followed by radiotherapy were performed. Clinical outcome and local recurrence was evaluated by modified visual analog scale for @entity158 , Frankel scale for @entity51 , and magnetic resonance imaging or computed tomography scans. Twenty-three cases (88.4%) had @entity615 before treatment with a visual analog scale score 6 or greater; @entity51 (FS A-D) was present in 19 cases (65.5%). RESULTS: Complete remission of @entity158 , lasting until @entity204 or progression of disease in another skeletal site, was obtained in 25/26 cases (96.1%). All @entity1 had complete recovery of @entity51 . No major morbidity occurred. No @entity1 had recurrence in the site of treatment. Median survival was 36 months (range, 3-60) and overall survival at one, three, and five years was 70%, 42%, and 34%, respectively. CONCLUSION: We provided evidence of surgery and radiotherapy to be feasible with limited morbidity. Clinical outcome has been highly satisfactory in terms of @entity158 and @entity66 control. The discussion of each case within a multidisciplinary team is of central importance in defining the most appropriate therapeutic approach.
