Tear function and ocular surface changes with topical mitomycin ( XXXX ) treatment for primary corneal intraepithelial neoplasia.

@entity1 @entity8046 @entity1138 @entity957 @entity1139 @entity1544
PURPOSE: To evaluate the tear function and ocular surface alterations in @entity1 with primary @entity8046 before and after treatment with topical @entity1138 ( @entity1139 ). @entity1 AND METHODS: We describe seven @entity1 with unilateral @entity8046 treated with 0.04% topical @entity1139 three times daily until full eradication of the lesion. The @entity1 underwent tear and ocular surface examinations including Cochet-Bonnet corneal sensitivity measurements, tear film break-up time (BUT), Schirmer test, and Rose-Bengal staining before, at the time of resolution of the @entity8046 , and at the final follow-up. Conjunctival impression cytology was performed before treatment and at the last visit. RESULTS: The mean pretreatment corneal sensitivity was 30.3 +/- 7.4 mm and improved to 55 +/- 5 mm at the final visit (P < 0.05). There were no aqueous-deficient eyes. The BUT values and Rose-Bengal staining scores also showed significant improvement at the last follow-up compared with the pretreatment values (P < 0.05). Initial impression cytology specimens showed goblet cell loss, higher grades of @entity1544 , areas of isolated keratinized, binucleated, and actively mitotic disfigured epithelial cells in all @entity1 . The mean goblet cell density and @entity1544 grade were observed to improve significantly at the last visit (P < 0.05). @entity1139 -induced cytologic changes were seen to persist long after cessation of treatment in some @entity1 . All eyes remained free of recurrence and complications during the follow-up period. CONCLUSION: We found 0.04% topical @entity1139 treatment tid until full eradication to be effective in the management of @entity8046 . The ocular surface disease of @entity8046 was characterized by disturbance of tear film stability, goblet cell loss, and @entity957 in all @entity1 . Impression cytology proved useful in attaining the diagnosis of @entity8046 , evaluating the effect of treatment, and showing @entity1139 -related long-term changes on the ocular surface.
