Early- and late-onset severe XXXX after renal transplantation.

@entity1 @entity358 @entity55
BACKGROUND: The aim of this study was to clarify the distinctions in the clinical characteristics and outcomes between early- and late-onset severe @entity55 after renal transplantation requiring ICU admission. METHODS: The data were retrospectively collected in consecutive renal recipients with severe @entity55 from January 1, 2009, to December 31, 2013, in a tertiary ICU. We classified the @entity1 according to the time of @entity55 onset as follows: early-onset severe @entity55 (E-SP) corresponded to a @entity358 occurring during the first year following the transplantation, and late-onset severe @entity55 (L-SP) corresponded to a @entity358 occurring after the first year following the transplantation. RESULTS: In the E-SP @entity1 , fungi (42.1%) and viruses (31.6%) were the most common pathogens. Twenty-three (71.9%) @entity1 received non-invasive ventilation (NIV), 15 (65.2%) of whom were intubated. The median duration of the ICU and hospital stays was 11    5 and 19    4 days, respectively. In the L-SP @entity1 , bacteria (42.1%) and viruses (26.3%) were the predominant pathogens. Four of 15 (26.7%) @entity1 failed NIV treatment. The median duration of the ICU and hospital stays was 9    3 and 16    3 days, respectively. The ICU mortality among the E-SP @entity1 was 18.8% (6 of 32), compared with 7.1% (2 of 28) in the L-SP group (P = 0.264). CONCLUSIONS: Early-onset severe @entity55 in renal transplant recipients resulted in a more serious condition, higher rate of NIV failure, longer duration of mechanical ventilation, and increased length of ICU and hospital stays.
