The significance of the frequency and occurrence of XXXX for treatment. Essential aspects of new Danish studies of the natural history of @entity0 .

@entity0 @entity5 @entity189 @entity3 @entity204
The natural history of @entity0 ( @entity0 ) has been evaluated by two entirely different types of consecutive and unselected materials: The general female population. Females with the @entity0 . The frequency of in situ @entity189 in the general female population is about 25 per cent. The growth pattern of the in situ @entity189 is predominantly microfocal contrary to findings in mammography selected surgical materials where @entity5 forming and/or diffuse types contribute to more than 30 per cent. Evidence is established of three different stages of the development of @entity0 : The benign epithelial hyperplastic stage, the microfocal in situ @entity189 stage and the @entity5 stage. Among females with the @entity0 -disease the residual breast glandular tissue in the contralateral breast develops a new primary @entity189 in 33 per cent and furthermore in situ @entity189 in another 35 per cent. @entity204 of disseminated @entity3 and axillary lymphnode @entity3 is significantly related to these new primaries. Residual breast glandular tissue left behind after total mastectomy contributes to new primary @entity189 . Thus among clinical chest-wall recurrences not less than 20 per cent were primary invasive @entity5 . Our investigations have considerable impact on treatment: As concern microfocal in situ lesions they support a conservative attitude as regard treatment, providing the females are included in prospective follow-up studies including mammography. As concern the contralateral breast they support a more active attitude, but more studies are needed. Meanwhile a close follow-up program is an inevitable consequence.(ABSTRACT TRUNCATED AT 250 WORDS)
