Endothelin and vein bypass grafts in experimental XXXX .

@entity407 @entity1373 @entity3361 @entity2553 @entity95 @entity11614 @entity731 @entity165
@entity11614 ( @entity11614 ) is a potent vasoconstrictor whose serum concentration increases with the development of @entity731 . Coronary artery-vein bypass grafts are susceptible to @entity2553 and to the development of accelerated @entity731 . Although @entity11614 is thought to play a role in @entity3361 , the effect of @entity11614 in atherosclerotic vein grafts is unknown. The responses of veins, arteries, and vein bypass grafts from normolipidemic and hyperlipidemic animals to @entity11614 were therefore investigated. Vein bypass grafts were placed in the carotid position of 12 New Zealand White @entity95 . Seven were fed a 1% @entity165 diet for 4 weeks before surgery and thereafter until harvest ( @entity407 ), and five were fed a normal diet (normolipidemia). Vein grafts, contralateral common carotid arteries, and jugular veins were harvested 4 weeks after surgery. Whereas there were no histologic changes in veins or carotids, normolipidemic vein grafts developed intimal @entity1373 and hyperlipidemic vein grafts developed @entity731 . Isometric tension studies with @entity11614 (10(-12) to 10(-6) M) showed that @entity407 increased the maximal tension generated to @entity11614 in the veins (660 +/- 80 to 1,110 +/- 140 mg, mean +/- SEM; p < 0.05), carotids (150 +/- 30 mg to 540 +/- 120 mg; p < 0.05), and vein grafts (180 +/- 20 to 450 +/- 60 mg; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
