[Prevalence of intestinal metaplasia of the @entity356 and its relation with @entity1534 strains XXXX and vacA].

@entity1 @entity1066 @entity299 @entity3621 @entity1534 @entity354 @entity2757 @entity356
BACKGROUND: Esophageal metaplasia progression is a consequence of chronic @entity354 (CGR). @entity1 with this condition are frequently infected by @entity1534 and show several symptoms including @entity3621 as well as @entity1066 formation. In addition, they present an increased risk for the development of @entity356 . Several pathogenic markers for @entity1534 such as ureC, vacA and @entity2757 genes have been described. Evidence indicates that direct injury to the epithelial mucosa is caused by cytotoxins and enzymes codified by these genes. We undertook this study to establish a relationship between the presence of pathogenic @entity1534 strains and the presence of metaplasia progression in @entity1 with CGR. METHODS: We detected the presence of @entity1534 @entity2757 and vacA positive strains in @entity1 with CGR. Using polymerase chain reaction, we analyzed 120 samples obtained from 60 @entity1 with CGR and 60 control group @entity1 , including samples from both anatomic areas: cardia and gastric antrum. RESULTS: We detected 56% of @entity1534 positive @entity1 ; 57.5% of these @entity1 were positive for either @entity2757 (+) and/or vacA(+) @entity1534 strains. Cardiac intestinal metaplasia was observed in 35% of the @entity1 . A marked tendency was observed to develop @entity299 in those @entity1 diagnosed with high-pathogenicity strains infected in both anatomic areas. CONCLUSIONS: These results suggest that infection with @entity1534 can be considered a risk factor for developing @entity356 .
