A family study of XXXX resulting from @entity1276 .

@entity1 @entity1032 @entity1276 @entity508 @entity850 @entity1141
@entity850 of the aqueduct of Sylvius accounts for about one third of cases of @entity1276 . At least 32 families have been reported in which the @entity1276 is inherited in an X linked fashion. In half of these families, flexed adducted thumbs were noted in some affected family members. Occasionally other male members were @entity1032 , suggesting limited expression of the gene. The problem of giving genetic advice to an isolated, clinically unremarkable, case of @entity1276 remains, so a family study was undertaken based on 24 such cases seen at The Hospital for Sick @entity1 over a 19-year period. There were 15 male and nine female index @entity1 . The diagnosis was confirmed in all cases by air encephalogram. One @entity1 had a radial club hand and another developed clasped thumbs secondary to @entity508 . No cases had @entity1141 . The 15 @entity1 had 18 brothers and 19 sisters, of whom one sister was similarly affected. The nine @entity1 had 12 sibs, none of whom was affected. This study, combined with a similar study in the USA, suggests that the empirical risk of recurrence of a sporadic case of @entity1276 is about 4.5%.
