Toxicokinetics and tissue distribution of @entity50105 in male adult XXXX following a single oral administration.

@entity50105 @entity137 @entity35 @entity32273 @entity2359
Abstract 1. @entity50105 ( @entity32273 ) is a new type of triazolinthione fungicide used worldwide. Despite its widespread use, the basic toxicokinetics (TK) information for health risk assessments of @entity32273 is limited. 2. TK behavior and metabolism studies of @entity32273 were performed in male adult Sprague Dawley (SD) @entity35 after a single oral administration. Serial blood and tissue samples were analyzed for their @entity32273 content by high-performance liquid chromatography (HPLC) to obtain comprehensive time-course data for estimation of TK parameters. 3. @entity32273 was rapidly but incompletely absorbed from the gastrointestinal tract of fasted adult @entity35 . It was widely distributed in all parts of body, but demonstrated little tendency to accumulate. And @entity32273 was excreted mainly in the form of parent compound. 4. The detection of @entity32273 in brain and testis proved that further investigations are required to determine whether @entity32273 could result in @entity2359 and @entity137 .
