[Antireflux anastomosis following resection of XXXX ].

@entity1 @entity5 @entity2910 @entity418 @entity1282 @entity354
OBJECTIVE: To investigate the antireflux effects of a modified Nissen fundoplication following esophagectomy for @entity5 . METHODS: From March 2006 to March 2007, 70 @entity1 with @entity418 were divided into two groups randomly. Esophagogastrostomy with a stapler only was perform in 35 @entity1 as controls (group C), and a modified Nissen fundoplication was added after esophagogastrostomy with stapler in the other 35 @entity1 as observed group (group O). There were 48 male and 22 female, ranging in age from 47 to 77 years (mean 60.1 years). The operative morbidity and mortality were recorded. Fourty-nine @entity1 were followed at 3 months after surgery, and the questionnaire of life quality (EORTC QLQ C-30) was conducted in 24 @entity1 in group C and 25 @entity1 in group O. Thirty @entity1 were examined with esophageal manometry, 24 h pH monitoring and gastroscopy. There were 16 @entity1 in group C and 14 @entity1 in group O. RESULTS: There was no significant difference in postoperative morbidity between the two groups (P > 0.05). However, the scores of heart burn and regurgitation in the group O were less than in group C (P = 0.041 and 0.034 respectively), but there was no difference in scores of @entity1282 between the two groups (P = 0.677). The pressure at the anastomotic site was higher than that in the stomach in group O (P = 0.032), but not in group C (P = 0.448). DeMeester score in group O was 53    46, compared to 140    103 in group C (P = 0.043). The score of @entity2910 was 0.9    0.8 in group O, which was lower than 1.6    1.0 in group C (P = 0.041). CONCLUSIONS: Addition of modified Nissen fundoplication after esophagectomy and esophagogastrostomy for @entity5 significantly increases the pressure at the anastomotic site, thus reduces the extent of @entity354 , which leads to the reduction of the extent of @entity354 and the improvement of the quality of life.
