Coupling of Molecular Imprinted Polymer Nanoparticles by High Performance Liquid Chromatography as an Efficient Technique for Sensitive and Selective Trace Determination of XXXX in Complex Matrices.

@entity1 @entity14457 @entity69361 @entity1042 @entity5022 @entity1626 @entity3824 @entity3679 @entity1543 @entity15906
BACKGROUND: @entity3824 ( @entity14457 ) is one of the most important pesticides which is extensively used to control weeds in arable farmland. Exposure to this compound occurs in general population and @entity1 who occupationally handle it. The aim of this present work was the preparation of @entity14457 imprinting polymer and its application as a selective sample preparation technique for trace determination of @entity14457 in biological and environmental samples. METHODS: In this study, @entity14457 imprinting polymer was obtained by precipitation polymerization using @entity3679 (the functional monomer), @entity15906 (the cross-linker), @entity69361 (the initiator) and @entity14457 (the template molecule) in @entity1626 solution. The MIP-NPs were characterized by thermogravimetric analysis and scanning electron microscopy. The optimization process was carried out applying batch method. After optimization of the parameters, affecting the adsorption and desorption of analyte, urine and different water samples were used to determine @entity14457 . RESULTS: Imprinted @entity14457 molecules were removed from the polymeric structure using @entity1543 in @entity1042 (20:80 v/v %) as the eluting solvent. Both sorption and desorption process occur within 10 min. The maximum sorbent capacity of the molecular imprinted polymer is 87.4 mg g-1. The relative standard deviation and limit of detection for water samples by introduced selective solid phase extraction were 4.8% and 0.9  g @entity5022 , and these data for urine samples were 4.5% and 1.60  g @entity5022 , respectively. CONCLUSION: The developed method was successfully applied to determine @entity14457 in urine and different water samples.
