Pregnancy Outcomes in Youth With Type 2 XXXX : The TODAY Study Experience.

@entity1 @entity154 @entity6 @entity28 @entity393
OBJECTIVE: We evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 @entity6 in Adolescents and Youth (TODAY) study. RESEARCH DESIGN AND METHODS: The TODAY study was a randomized controlled trial comparing three treatment options for youth with type 2 @entity6 . Informed consent included the requirement for contraception, including abstinence; this was reinforced at each visit. Following informed consent, self-reported data related to the mother's prenatal care and delivery and the @entity1 's health were retrospectively collected. When permitted, maternal medical records and @entity1 birth records were reviewed. RESULTS: Of the 452 enrolled female @entity1 , 46 (10.2%) had 63 pregnancies. Despite continued emphasis on adequate contraception, only 4.8% of the pregnant @entity1 reported using contraception prior to pregnancy. The mean age at first pregnancy was 18.4 years; the mean @entity6 duration was 3.17 years. Seven pregnancies were electively terminated; three pregnancies had no data reported. Of the remaining 53 pregnancies, 5 (9.4%) resulted in early @entity393 , and 7 (13%) resulted in loss with inadequate pregnancy duration data. Two pregnancies ended in stillbirth, at 27 and 37 weeks, and 39 ended with a live-born @entity1 . Of the live-born @entity1 , six (15.4%) were preterm and eight (20.5%) had a major @entity154 . CONCLUSIONS: Despite @entity6 -specific information recommending birth control and the avoidance of pregnancy, 10% of the study @entity1 became pregnant. Pregnancies in youth with type 2 @entity6 may be especially prone to result in @entity154 . Reasons for the high rate of @entity154 are uncertain, but may include poor metabolic control and extreme @entity28 .
