XXXX following major @entity542 .

@entity1 @entity251 @entity1640 @entity542 @entity2730 @entity1176 @entity6126 @entity444
Endocrine studies, using the four hypothalamic releasing hormones, gonadotrophin releasing hormone, thyrotrophin releasing hormone, corticotrophin releasing hormone and growth hormone releasing hormone, were performed in 33 males after admission with a major @entity542 . The test was repeated 7 days later in all 33 @entity1 and after 3-6 months in 21 @entity1 . All @entity1 had a period of unconsciousness followed by post-traumatic @entity2730 of greater than 24 h. The results obtained from investigating the @entity444 are reported in this paper. The levels of total and free @entity251 , basal FSH and basal LH fell significantly during the first 3 days after injury, when the LH and FSH responses to @entity1176 achieved their highest peak levels. This hormone pattern has not previously been reported in the @entity444 and may be a consequence of @entity1640 . The severity of the injury was negatively correlated to the @entity251 concentration on admission and to the basal and peak FSH concentrations 1 week later. Persistent @entity6126 was found in five of the 21 @entity1 retested after 3-6 months, with low @entity251 concentrations and three continued to have an exaggerated LH response to @entity1176 . Thus major @entity542 frequently results in @entity6126 shortly after injury, with an increased gonadotrophin response to @entity1176 . In addition, a substantial minority of @entity1 continue to be hypogonadal after 3-6 months. In view of these findings we strongly suggest that all @entity1 should be endocrinologically assessed at intervals following severe @entity542 .
