Volume Overload: Prevalence, Risk Factors and Functional Outcome in Survivors of XXXX .

@entity1 @entity82 @entity326 @entity73 @entity221 @entity1284
RATIONALE: Survivors of @entity326 have impaired functional status. @entity1284 is associated with poor outcomes in @entity1 with @entity326 , but the impact of @entity1284 on functional outcome and discharge destination of survivors is unknown. OBJECTIVES: This study describes patterns of fluid management both during and after @entity326 , and examines factors associated with @entity1284 on intensive care unit (ICU) discharge. We then examine associations between @entity1284 on ICU discharge and mobility limitation and discharge to a healthcare facility in @entity326 survivors, with the hypothesis that @entity1284 is associated with increased odds of these outcomes. METHODS: We retrospectively reviewed the medical records of 247 @entity1 admitted with @entity326 to an academic county hospital from June 2009 to April 2012, who survived to ICU discharge. We defined @entity1284 as a fluid balance expected to increase the subject's admission weight by 10%. Statistical methods included unadjusted analyses and multivariable logistic regression. MEASUREMENTS AND MAIN RESULTS: Eighty-six percent of @entity1 had a positive fluid balance and 35% had @entity1284 on ICU discharge. Factors associated with @entity1284 in unadjusted analyses included more @entity221 , @entity82 , blood transfusion during shock, and higher volumes of fluid administration both during and after shock. Blood transfusion during shock was independently associated with increased odds of @entity1284 (odds ratio [OR] 2.65, 95% confidence interval [CI] 1.33-5.27, p=0.01) after adjusting for pre-existing conditions and severity of illness. Only 42% of @entity1 received at least one dose of diuretic during their hospitalization. @entity1284 on ICU discharge was independently associated with inability to ambulate on hospital discharge (OR 2.29, 95% CI 1.24-4.25, p=0.01) and, in @entity1 admitted from home, discharge to a healthcare facility (OR 2.34, 95% CI 1.1-4.98, p=0.03). CONCLUSIONS: @entity1284 is independently associated with @entity73 and discharge to a healthcare facility in survivors of @entity326 . Prevention and treatment of @entity1284 in @entity1 with @entity326 warrants further investigation.
