Autofluorescence imaging of potentially XXXX .

@entity1 @entity5 @entity75 @entity957 @entity33 @entity3137 @entity2784 @entity6349
OBJECTIVE AND STUDY DESIGN: Several noninvasive adjunctive methods have been proposed for identification of potentially @entity5 . The VELscope is an optical device for detecting spatial changes in mucosa autofluorescence caused by @entity75 in conjunction with an intraoral exam. The aim of our prospective study was to correlate loss of autofluorescence from undiagnosed mucosa lesions with histology. RESULTS: In total 64 @entity1 considered at risk for @entity957 (20 had previous OSCC) were included in the study. Regions with fluorescence visualization loss were considered as malignant or @entity6349 . All @entity1 underwent biopsy after VELscope examination. In 22 @entity1 (34.4%) a loss of autofluorescence indicating a @entity2784 ( @entity2784 ) or @entity3137 was detected. The sensitivity of identification of malignant and @entity6349 areas with the VELscope was 100% and the specificity was 80.8%, respectively, compared with histology as gold standard. The positive predictive value was 54.5% and the negative predictive value was 100% respectively. CONCLUSION: Evaluation of autofluorescence imaging with VELscope can assist in the identification of malignant and potentially malignant oral lesions from normal mucosa in high-risk @entity1 but does not help discriminating benign lesions from malignant or @entity33 .
