Smoking affects the oral @entity413 tolerance test profile and the relationship between XXXX and @entity6 .

@entity1 @entity413 @entity6 @entity4051
AIMS: Current smokers in the general population have a lower 2 h plasma @entity413 after an oral @entity413 tolerance test (OGTT) and a higher HbA1c than non-smokers, but the relationships between OGTT/HbA1c and smoking status have not been addressed in pregnancy. We analysed glycaemic measurements in @entity1 with @entity6 in relation to smoking status. METHODS: We performed a review of the prospectively collected database of the @entity6 . We included @entity1 with @entity6 and a singleton pregnancy who delivered between 1986 and 2006. Bivariate and multivariate analyses were used to evaluate @entity1 characteristics in relation to smoking status. RESULTS: A total of 2361 @entity1 met the inclusion criteria: 556 (23.5%) were active smokers, 266 (11.3%) quit during pregnancy and 1539 (65.2%) were non-smokers. Most baseline characteristics were similar across groups. Diagnostic OGTT was performed at a gestational age of [median (25th, 75(th) centiles)] 29 weeks (26, 33). @entity1 who smoked at the beginning of pregnancy had a higher 1-h plasma @entity413 than non-smokers [11.8 (11, 12.7), 11.6 (11, 12.6) and 11.5 (10.8, 12.5) mmol/l, for active smokers, those who quit during pregnancy and non-smokers, respectively, P < 0.001] and a lower 3-h plasma @entity413 [7.3 (5.9, 8.4), 7.6 (6.4, 8.7) and 8.0 (6.8, 9.0) mmol/l, respectively, P < 0.001]. HbA1c was higher in @entity1 who smoked at the beginning of pregnancy. Multiple regression analysis confirmed the independent association of smoking status with HbA1c and OGTT plasma @entity413 . CONCLUSIONS: In @entity1 with @entity6 who smoke at the beginning of pregnancy, the shape of the OGTT is consistent with accelerated @entity413 absorption, and @entity4051 c is higher than expected for glycaemic values.
