microRNA-762 promotes XXXX cell proliferation and invasion by targeting @entity26242 expression.

@entity1 @entity26242 @entity0 @entity5 @entity71694
OBJECTIVES: miRNAs play crucial roles in @entity1 tumourigenesis. This study was performed to measure expression and function of @entity71694 in @entity0 . MATERIALS AND METHODS: Expression of @entity71694 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time RT-PCR. We restored expression of @entity71694 in MCF-7 cells to measure its functional roles. Luciferase assays were performed to reveal the target gene of @entity71694 . RESULTS: Expression of @entity71694 was high in both @entity0 cell lines and specimens, and its overexpression increased @entity0 cell proliferation and invasion. @entity26242 ( @entity26242 ) is a direct target of @entity71694 and overexpression of @entity71694 reduced expression of @entity26242 . Moreover, @entity26242 was repressed, its levels inversely correlated to @entity71694 expression. @entity26242 rescued @entity71694 -induced cell invasion and proliferation. CONCLUSIONS: These results demonstrate that @entity71694 @entity5 effect was achieved by targeting @entity26242 in @entity1 @entity0 specimens.
