XXXX requiring surgery. Clinical and pathologic study.

@entity1 @entity712 @entity339 @entity3454 @entity854 @entity397 @entity2224 @entity955 @entity340
The clinical, hemodynamic, surgical, and pathologic findings in 30 @entity1 who required mitral valvular surgery and who had a preoperative diagnosis of @entity3454 were reviewed. The mean age of the @entity1 was 59.5 years; 28 @entity1 were over 45 years of age and 10 were over 60 years. Surprisingly, 20 were males. A long history of systolic murmur was common, whereas symptoms of @entity712 were of abrupt onset. At the time of surgery, a local holosystolic murmur typical of @entity339 was present, although a mid- to late systolic click was not heard in any of the @entity1 . @entity854 were present in all @entity1 , with 13 @entity1 demonstrating @entity955 . Only four @entity1 had a normal heart size radiographically. Echocardiography confirmed the radiographic findings, in that 27 @entity1 demonstrated left @entity2224 . All 29 @entity1 undergoing cardiac catheterization and angiography demonstrated a prolapsing mitral valve with severe regurgitation. Surgical and pathologic examination revealed findings characteristic of a @entity340 in all @entity1 , with 19 also demonstrating @entity397 . This study demonstrates that @entity712 requiring valvular surgery occurs in a subset of @entity1 with @entity3454 . In this subset, males predominate and most are over 50 years of age. These @entity1 may be asymptomatic for many years, demonstrating mild to moderate mitral @entity340 , before @entity712 develops.
