Cancer risk estimates for family members of a population-based family registry for XXXX .

@entity5 @entity0 @entity43 @entity5344
Population-based @entity5344 family registries can facilitate studies to evaluate genetic and environmental factors in the etiology of these @entity5 . The purpose of this study is to describe what is, as far as we know, the first population-based @entity5344 family registry and to estimate @entity5344 risk in relatives of @entity5344 probands. Population-based consecutive incident cases of @entity5344 were invited to participate in the University of California, Irvine breast and ovarian family registry. In this study, we report data on 1567 @entity0 and 328 @entity43 probands. The operational components of this family registry include enrollment of probands, family history interviewing, confidentiality, pathology, verification and review, biospecimen bank, statistical/genetic analysis, and special studies on positional cloning of known genes. All of the components are tracked through the University of California, Irvine Genetic Research Information System. In @entity0 probands, relative risk (RR) of @entity0 in mothers and sisters is significantly elevated [RR = 1.7 and 95% confidence interval (CI) = 1.4-2.0 and RR = 2.8 and 95% CI = 2.3-3.3, respectively]. In families of @entity43 probands, mothers are at increased risk of @entity43 (RR = 4.6; 95% CI, 2.1-8.7). RR of @entity0 in mothers of @entity0 probands is significantly elevated (RR = 4.9; 95% CI, 2.6-8.5). No elevation of @entity5344 risk was observed among relatives of Asian probands. In general, there is a decrease in RR among mothers and sisters with increase in age of onset of probands. In second-degree relatives and first cousins, the @entity0 hazards ratios increase with increase in the number of affected first-degree relatives and decrease with increase in age at onset of the proband.
