Effects of Electronic XXXX Delivery System on Larynx: Experimental Study.

@entity32 @entity1711 @entity1239 @entity1373 @entity1710 @entity4648 @entity35
OBJECTIVE: We aimed to assess the effects of electronic @entity1239 delivery system (ENDS) or also termed electronic cigarette vapor on the laryngeal mucosa of @entity35 . MATERIALS AND METHODS: Sixteen female @entity35 albino @entity35 were divided into two groups. The study group was exposed to ENDS vapor for 1  hour/day for 4  weeks. The control group was not subjected to any chemical or physical stimulus. The vocal folds of the study and control group @entity35 were evaluated histopathologically by @entity1710 and @entity1711 staining and immunohistochemically by Ki67 staining. Epithelial distribution, @entity32 , @entity1373 , and @entity4648 were evaluated. RESULTS: Epithelial distribution and @entity32 did not differ between the two groups. Two cases of @entity1373 were detected in the study group but there was no @entity1373 in the control group. Four cases of @entity4648 were detected in the study group and one case in the control group. Statistical analysis revealed no significant difference between the study and control groups (P  =  0.131 and 0.106, respectively). CONCLUSIONS: Exposure to ENDS for 4  weeks caused @entity1373 and @entity4648 of the laryngeal mucosa of @entity35 but this was not significant statistically. These results implemented that further studies with larger cohort and longer duration are required to evaluate long-term effects.
