Higher serum TSH in XXXX @entity1 occurs independent of age and correlates with extrathyroidal extension.

@entity5 @entity1 @entity2621 @entity259
BACKGROUND: It has previously been shown that higher serum TSH is associated with @entity259 incidence and @entity5 . In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for @entity259 , it is important to know whether higher TSH in @entity1 with @entity259 occurs independent of age. OBJECTIVE: To determine the relationship between higher TSH, @entity5 and age. DESIGN: A retrospective cohort study. @entity1 AND METHODS: A total of 1361 @entity1 underwent thyroid surgery between May 1994 and December 2007 at a single institution. Of these @entity1 , 954 had pathological data, preoperative TSH and complete surgical history available. Data were analysed in relation to age and TSH. RESULTS: Mean TSH was significantly higher in @entity5 @entity1 regardless of age < 45 years or >or= 45 years (P = 0.046 and P = 0.027, respectively). When examining age groups < 20, 20-44, 45-59 and >or= 60 years, there was a trend of rising mean TSH with age. Despite the rise in the benign subgroups, mean TSH was consistently higher in those with @entity5 vs. those without. On multivariate analysis, higher TSH was independently associated with @entity5 (P = 0.039) and pathological features of @entity2621 (P = 0.001) but not with age (P = 0.557). On multivariate analysis of high-risk features associated with poor prognosis, there was a significant association between higher TSH and extrathyroidal extension (P = 0.002), whereas there was no clear relationship with age, @entity5 size > 4 cm, and distant metastases. CONCLUSION: Independent of age, @entity259 incidence correlates with higher TSH. Higher TSH is associated with extrathyroidal extension of disease.
