XXXX Repair in the Distal Radius in Postmenopausal @entity1 : A Follow-Up 2 Years Postfracture Using HRpQCT.

@entity1 @entity79 @entity174
UNASSIGNED: @entity174 healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable @entity174 within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in @entity79 ( @entity79 ), microarchitecture, and @entity79 after a @entity174 during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline @entity79 , microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal @entity1 (mean age 64        8 years) with a conservatively treated @entity174 was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. @entity79 , microarchitecture, and stiffness parameters were determined and the @entity174 side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year @entity79 with baseline @entity79 , microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p < 0.05), whereas @entity79 was similar. Two-year torsional and bending stiffness correlated significantly with baseline @entity79 and cortical perimeter ( rho  >=  0.63, p < 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that @entity174 healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in @entity79 , microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower @entity79 and higher cortical perimeter at baseline.    2015 American Society for Bone and Mineral Research.
