Prevalence of age-related XXXX in a rural Chinese population: the Handan Eye Study.

@entity1 @entity1020 @entity75 @entity13785
PURPOSE: To describe the prevalence of age-related degeneration ( @entity13785 ) in a rural Chinese population and to assess its associations with age, gender, and smoking. DESIGN: Population-based cross-sectional. @entity1 : @entity1 aged 30+ years, recruited between October 2006 and October 2007, from Yongnian County, Handan, Hebei Province, China. METHODS: All @entity1 underwent a standardized interview and comprehensive eye examinations, including digital retinal photography of both eyes. Trained graders assessed the presence and severity of @entity75 following the modified @entity1020 ( @entity1020 ) used in the Blue Mountains Eye Study (BMES). Direct age standardization to the world population (year 2000) was performed to compare the prevalence across different populations. MAIN OUTCOME MEASURES: @entity13785 and @entity1020 . RESULTS: Of 6830 participates, fundus photographs were gradable for 6581 @entity1 (96.4%), including 4049 aged 50+ years. Early and late @entity13785 prevalence rates were 3.0% and 0.1%, respectively, among @entity1 . The age-standardized prevalence rates among @entity1 aged 50+ years were 4.7% and 0.2%, respectively. After controlling for age, @entity1 had a higher prevalence of early (3.9% vs. 2.3%, odds ratio [OR] 1.7; 95% confidence interval [CI], 1.3-2.2) and late @entity13785 (0.1% vs. 0.03%; OR 3.5; CI, 0.4-33.4) compared with @entity1 . Older age (sex-adjusted OR 1.7; CI, 1.3-2.2 per decade of age) and current smoking (age-sex-adjusted OR 1.4; CI, 1.0-2.1) were significantly associated with early @entity13785 prevalence. The proportion of current smokers was substantially higher in @entity1 (58.7%) than in @entity1 (0.3%). The attributable risk of early @entity13785 from smoking among Chinese @entity1 was 24.2%. After controlling for current smoking, the excess prevalence of early @entity13785 in @entity1 compared with @entity1 reduced by 50% (OR 1.4; 95% CI, 0.9-2.0). CONCLUSIONS: The prevalence of early @entity13785 in this rural Chinese sample was similar to white @entity1 in the BMES and Asian Malays in the Singapore Malay Eye Study. Late @entity13785 prevalence, however, was lower. Higher prevalence rates for early and late @entity13785 in @entity1 compared with @entity1 were largely attributed to substantially higher proportions of smokers in rural Chinese @entity1 than in @entity1 .
