Positive effect of XXXX treatment in @entity8882 .

@entity1 @entity442 @entity2124 @entity6038 @entity8882
OBJECTIVE: @entity8882 (matUPD(14)) resembles @entity6038 ( @entity6038 ). As positive effects of @entity2124 ( @entity2124 ) are observed in individuals with @entity6038 , treatment with @entity2124 may be useful in individuals with matUPD(14) as well. The aim of this study was to investigate the effect of @entity2124 treatment on growth and body composition in @entity1 with matUPD(14). DESIGN: This is a prospective observational study of @entity2124 treatment in two @entity1 with matUPD(14) during 2  years, and spontaneous growth in another matUPD(14) @entity1 of similar age. @entity1 : Three @entity1 ( @entity1 A, B and C, aged 8  9, 11  4 and 12  7  years, respectively) with matUPD(14) were included in this study. MEASUREMENTS: @entity1 A and B were treated with @entity2124 during 2  years. @entity1 C was not treated with @entity2124 , as she was diagnosed at an age at which she attained near-final height. Main outcome measures included height, weight, body proportions, @entity442 , bone age, and DXA scan for body composition. RESULTS: In both treated @entity1 , a considerable increase in height (from -2  3SD and -1  2SD to -1  2SD and -0  6SD, respectively) and @entity442 levels (from +0  1SD and -1  4SD to +1  3SD and +0  9SD, respectively) and, in @entity1 A, a decrease in weight (+1  2 SD to -0  7SD), and improved body composition (fat percentage from 51  5% to 45  4%) were found. Both experienced improved muscle strength. CONCLUSIONS: @entity2124 treatment in matUPD(14) cases can show beneficial effects on growth and body composition if started in time. Larger, international studies to determine detailed effectivity and side effects are suggested.
