The value of posttransplant monitoring of interleukin (IL)-2, XXXX , @entity3646 , @entity650 , @entity687 , and soluble @entity7527 in the plasma of renal allograft recipients.

@entity1 @entity650 @entity2772 @entity7527 @entity1199 @entity3646 @entity687
Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity1199 , @entity2772 , @entity3646 , @entity650 , @entity687 , and soluble @entity7527 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity1 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity1 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity1199 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity3646 and @entity650 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity2772 , @entity687 , and soluble @entity7527 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity1 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.
