Association of Severe @entity131 XXXX Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

@entity1 @entity131 @entity73 @entity16 @entity10166 @entity177
BACKGROUND: Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. @entity177 is associated with worse outcomes in various acute @entity16 . An integrative approach is presently used according to the existing paradigm for the association of series of temporal @entity73 with the outcomes of @entity1 with @entity131 ( @entity131 ). OBJECTIVE: To explore the influence of the duration of @entity73 events on severe @entity131 @entity1 outcomes. @entity1 age was also included in the analysis of the prospectively collected clinical data. METHODS: CA monitoring included 33 prospective severe @entity131 @entity1 . The pressure reactivity index [ @entity10166 (t)] was continuously monitored to collect information on the dynamics of CA status and to analyze associations between the duration of the longest @entity73 event and @entity1 outcomes. RESULTS: The Glasgow outcome scale and the duration of the longest @entity73 were negatively correlated. The duration of autoregulation impairment significantly correlated with worse outcomes. Multidimensional representation of Glasgow outcome scale plots showed that better outcomes were obtained for younger @entity1 (age < 47 years) and those whose longest @entity73 event was shorter than 40 minutes if @entity10166 (t) was above 0.7 in the @entity73 event. CONCLUSION: Unfavorable outcomes for @entity131 @entity1 are more significantly associated with the duration of the single longest @entity73 episode at a high @entity10166 (t) value, rather than with averaged @entity10166 (t) values or the average time of all @entity73 episodes. ABBREVIATIONS: ABP, arterial blood pressureABP(t), continuous reference arterial blood pressureCA, cerebrovascular autoregulationCBF, cerebral blood flowCPP, cerebral perfusion pressureGOS, Glasgow outcome scaleGOSHD, Glasgow outcome scale after hospital dischargeGOS6M, Glasgow outcome scale at 6 months after dischargeICP, intracranial pressureICP(t), continuously monitored intracranial pressureLCAI, longest CA impairmentoptCPP, optimal cerebral perfusion pressurePRx(t), pressure reactivity indexTBI, @entity131 .
