The treatment of XXXX : outcomes of bone marrow transplantation and immunosuppressive therapy in a single institution of Korea.

@entity1 @entity548 @entity2150 @entity281 @entity2132 @entity5501 @entity204
The present study represents an analysis of 96 @entity1 with @entity2150 ( @entity2150 ) treated in Seoul National University Hospital, Seoul, Korea between 1990 and 1999. Twenty-two @entity1 were treated by allogeneic bone marrow transplantation (BMT) from HLA identical sibling donors and 74 by immunosuppressive therapy (IS) with antithymocyte globulin (ATG) or antilymphocyte globulin (ALG). There was no statistical difference between the two treatment groups in age, sex, disease duration, and previous transfusion amount. In the BMT group, grade II-IV acute @entity2132 ( @entity2132 ) developed in 10% and chronic @entity2132 occurred in 33% of @entity1 . Only one @entity1 died from complication of transplantation ( @entity5501 ). Of 74 @entity1 who received IS treatment, 45% achieved a complete or partial response. Twenty @entity1 died among IS treatment group. Major causes of @entity204 were @entity548 (40%) and @entity281 (55%). In the BMT group, the 5-yr overall survival (OS) was 95% after a median follow-up of 42 months. In the IS group, the 5-yr OS was 70% after a median follow-up of 49 months (p=0.04). In conclusion, the long-term survival rates of @entity2150 in Koreans receiving BMT or IS were excellent compared with the Western data. Further evaluation on the prognosis of @entity2150 in Asians should be done.
