Global and segmental left ventricular function in XXXX .

@entity1 @entity712 @entity8674 @entity68
The systolic and diastolic left ventricular (LV) function was studied by M-mode echocardiography in 60 @entity1 with @entity8674 (mean age +/- SD, 17.1 +/- 7.5 years) and 30 healthy controls (15.4 +/- 3.8 years). In thalassemic @entity1 , echocardiograms were obtained 48 h posttransfusion, with a mean hemoglobin level of 12.4 +/- 0.9 g/dl. To examination time, thalassemic @entity1 had received 30-774 blood units (318 +/- 176). @entity712 ( @entity712 ) was present in 14 thalassemic @entity1 (19.6 +/- 3.4 years), while 46 (16.3 +/- 8.2 years) had no clinical signs of @entity712 . Global LV function study showed enlarged LV dimensions in thalassemic @entity1 with @entity712 (p less than 0.001) and similar cavity size in controls and @entity1 without @entity712 (p = NS). The same was true for velocity measurements, while diastolic LV indices had similar values in all groups (p = NS). Segmental LV function study showed no significant differences in systolic and diastolic LV posterior wall behavior between thalassemic @entity1 and controls, and even more, between thalassemic @entity1 with and without @entity712 , while it was independent of @entity68 load. These findings indicate that global and segmental LV function in thalassemic @entity1 remain within normal limits until the final stages of the disease. @entity712 onset marks the deterioration of LV systolic performance, while global and segmental diastolic indices do not change significantly. The above findings question the role of @entity68 overload in the development of @entity712 in @entity8674 .
