The roles of chemotherapy and surgery in XXXX and the influence of prognostic factors on survival.

@entity1 @entity880 @entity3 @entity420 @entity356
In this study, we present the results of surgery and chemotherapy and the impact of various prognostic factors on survival in @entity1 with @entity356 with a follow-up of 6 years. All of the 328 cases were @entity420 histologically and had a median age of 55 years. Median survival was 11 months, and the 5-year survival rate was 18%. Nonmetastatic cases were associated with improved survival as compared with the cases with @entity3 (p<0.001). @entity1 with gastrectomy had improved survival (p<0.001). Subtotal gastrectomized @entity1 had better survival rates in comparison to the total gastrectomized @entity1 (p = 0.03). Addition of splenectomy to total gastrectomy and adjuvant chemotherapy did not influence survival rates (p>0.05). In metastatic @entity1 , we determined beneficial effects of gastrectomy and chemotherapy on survival. The benefit was most predominant in chemoresponsive @entity1 (p<0.001). Higher serum CA 19.9 levels in @entity1 without @entity3 , higher serum @entity880 dehydrogenase and carcinoembryonic antigen levels in @entity1 with @entity3 , and lower serum albumin levels in both stages were determined as significant predictors of poor survival. On multivariate analysis, only higher serum CA 19.9 level was the independent unfavorable prognostic factor of survival time in nonmetastatic @entity1 (p = 0.008). In @entity3 , older age (p = 0.03) and male gender (p = 0.05) were associated with poorer survival. In conclusion, @entity356 is a great health problem, especially in developing countries, and we need more optimal approaches and treatment modalities for @entity356 .
