XXXX in the young: trends, characteristics and outcome.

@entity1 @entity5 @entity14 @entity1349
BACKGROUND: @entity14 ( @entity14 ) in young @entity1 is associated with a poor outcome due to advanced stage at diagnosis and poor differentiation. AIM: The aim of this study is to compare clinicopathological characteristics, @entity1349 ( @entity1349 ) and disease-free survival (DFS) of young ( <=40 years) and older @entity1 with @entity14 . METHODS: A total of 2,538 @entity1 including 59 young @entity1 (age  <=40 years) with @entity14 were identified over 20 years. The clinicopathological variables of young @entity1 were compared with a group of consecutive older @entity1 (n = 416) spanning both decades. Survival analysis was done using Kaplan-Meier, log-rank and Cox regression models. RESULTS: The frequency in young @entity1 increased from 1.4% to 3.0% from first to second decade (overall -2.3%, p = 0.006). There was a higher frequency of @entity5 with poor differentiation (43% vs. 16%, p = < 0.001), T4 stage (47% vs. 30%, p = 0.005) and vascular invasion (VI; 38% vs. 29%, p = 0.13) in younger group. There was no significant difference in @entity1349 (p = 0.116) and DFS (p = 0.261) between the two groups. Node-negative young @entity1 had a significantly better @entity1349 (p = 0.046). Young @entity1 with VI had significantly reduced @entity1349 (p = 0.043), whereas young @entity1 without VI had significantly better @entity1349 (p = 0.012). Multivariate analysis showed T4 status (p = 0.001) and vascular invasion (p = 0.002) as independent prognostic factors for @entity1349 and T4 status (p = 0.004) as independent factor influencing DFS. CONCLUSION: The frequency of @entity14 in young @entity1 increased significantly. Vascular invasion is the single most important prognostic factor in young @entity14 . Along with vascular invasion, high proportion of T4 status in young @entity1 increases the chances of recurrence and negates any survival advantage in young @entity1 .
