[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in XXXX with laryngopharyngeal reflux].

@entity1 @entity51 @entity4546 @entity304
OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in @entity1 with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A (30 cases) taked golden voice capsule to treat for 3 months, while the individuals in group B (30 cases) taked golden voice capsule and @entity4546 to treat for 3 months. The data about @entity304 ( @entity304 ), @entity51 ( @entity51 ) and voice handicap index (VHI)from the first month to the third month after treatment were recorded and compared group A with group B. RESULT: The scores of @entity304 and @entity51 in @entity1 (60 cases) before treatment were significantly correlated with their VHI (r=0. 823, P<0. 01; r=0. 873, P<0. 01). The score changes of @entity304 and VHI from the first to the third month after treatment in group B were significantly higher than those in group A (P<0. 01). Meanwhile, the score changes of @entity51 from the third month after treatment in group B were significantly higher than those in group A (t=8. 307, P<. 01), but the differences were not significant for @entity51 from the first to the second month after treatment between group A and group B(t=1. 128, P>0. 05; t=0. 376, P> 0. 05). CONCLUSION: PPI therapy could significantly alleviate the hoarseness symptom in LPR @entity1 .
