Natural history, symptoms and treatment of the XXXX .

@entity1 @entity2725 @entity2726 @entity64 @entity8991 @entity101 @entity2724 @entity1833 @entity889 @entity2645 @entity892 @entity717
This study describes the clinical features, natural history and treatment of 100 @entity1 with @entity2724 . Over half had one or more affected relatives. Symptoms commenced in adolescence or early adult life in most @entity1 , and remissions were uncommon. @entity2724 occurred several times each day, often in unusual circumstances and sometimes with little warning. The mean total sleep time of narco-leptics was a little over 9 hours in each 24 hour period, as compared with under 8 in normal subjects. Cataplexy occurred in 93 @entity1 , most commonly when subjects were tired. Attacks were similar in nature to physiological weakness with laughter, although other sudden sensory or emotional stimuli did not cause paralysis of @entity717 nor loss of muscle tone in normal subjects. Half these @entity1 had frequent dreams before the onset of proper sleep, and 62 had @entity2726 . This was often frightening, with feelings of suffocation, accompanied by dreams, and of uncertain length. A minority of @entity1 with @entity2724 had muscle aches and jerks before sleep, @entity892 or loss of focus during @entity2725 , went sleep-walking by day, and had daytime @entity1833 . @entity889 had been given to 71 @entity1 for periods of up to 33 years with adequate, but rarely complete, control of @entity2724 . Side effects were common and almost half these @entity1 became tolerant, needing higher dosage to control symptoms. Three @entity1 had a @entity64 whilst taking @entity889 . @entity2645 or @entity8991 had ben given in combination with @entity889 to 33 @entity1 for periods of up to 6 years with considerable improvement in both @entity2725 and @entity2726 , and few side effects. Sustained or paroxysmal @entity101 as a result of @entity889 or combined treatment did not occur.
