Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and XXXX .

@entity1 @entity8242 @entity6 @entity1219 @entity1798 @entity413
The effect of highly purified natural porcine @entity8242 on C-peptide release was examined in six type I (insulin-dependent) diabetics ( @entity1798 ) with residual beta-cell function, six type II non-insulin-dependent) diabetics (NIDD), and six normal subjects. All subjects were normal weight. From -120 minutes to 180 minutes @entity413 or insulin was infused IV to achieve a constant plasma @entity413 level of 8 mmol/L. On two separate days @entity8242 (2 pmol/kg/min) or isotonic @entity1219 at random were infused from 0 to 30 minutes. After 10 minutes of @entity8242 infusion plasma IR- @entity8242 concentrations were in the physiologic postprandial range. At 30 minutes a further increase in IR- @entity8242 to supraphysiologic levels occurred. In all subjects plasma, C-peptide increased more after 10 minutes of @entity8242 infusion ( @entity1798 , 0.48 +/- 0.05; NIDD, 0.79 +/- 0.11; normal subjects, 2.27 +/- 0.29 nmol/L) than on the corresponding day with @entity1219 infusion ( @entity1798 , 0.35 +/- 0.03; NIDD, 0.62 +/- 0.08; normal subjects, 1.22 +/- 0.13 nmol/L, P less than .05 for all). The responses of the diabetics were significantly lower than that of the normal subjects (P less than .001 for both groups). No further increase in C-peptide occurred during the remaining 20 minutes of the @entity8242 infusion in the @entity6 subjects ( @entity1798 , 0.49 +/- 0.05; NIDD, 0.83 +/- 0.10 nmol/L). In the presence of a plasma @entity413 concentration of 8 mmol/L, physiologic concentrations of porcine @entity8242 caused an immediate but impaired beta-cell response in @entity1798 and NIDD @entity1 .
