Bone marrow transplantation for XXXX from donors other than HLA identical siblings: a report of the BMT Working Party.

@entity1 @entity55 @entity2150 @entity205 @entity281 @entity2132 @entity2149 @entity1499
Data were obtained from 46 @entity1 with @entity2150 ( @entity2150 ) who received bone marrow transplants (BMT) from donors other than genotypically HLA-identical siblings. The data were collected in the @entity2150 Registry of the European Bone Marrow Transplant Group. The donors were non-HLA-identical siblings in six cases, parents in 28 cases, a son in one case and unrelated individuals in 11 cases. Fifteen donor-recipient pairs were @entity2149 identical and mutually non-reactive in mixed lymphocyte culture; nine were mismatched at one locus, 17 were mismatched at two or more loci and in five cases data were not available for D/DR determinants. Actuarial survival was predicted by the degree of mismatch. It was 45% for phenotypically HLA-identical grafts, 25% for grafts mismatched at one locus and 11% for graft mismatched at more than one locus. Whether the graft was derived from a family member or an unrelated donor seemed to be less important and results were comparable. Age, @entity1 sex and year of transplant had no significant influence on survival. The use of @entity205 (CSA) for @entity2132 ( @entity2132 ) prophylaxis (n = 21, survival 34%) appeared superior to both @entity1499 (n = 9, survival 11%) and to CSA with T cell depletion of donor marrow (n = 13, survival 14%). The causes of death were rejection (n = 15), @entity2132 (n = 13), @entity55 (n = 5) and @entity281 (n = 1). Twelve @entity1 are alive at 16-84 months post-BMT.(ABSTRACT TRUNCATED AT 250 WORDS)
