Implants of noninvasive XXXX in peritoneum and ileocolonic neobladder: support for "seed and soil" hypothesis of bladder recurrence.

@entity1 @entity1377 @entity8 @entity5 @entity254 @entity189
OBJECTIVES: To explore the underlying mechanism of @entity5 regrowth in cases of noninvasive @entity189 that recur in unusual anatomic locations. METHODS: The pathology files of our institution and the consult service of one of us were searched for cases of noninvasive nonmetastatic @entity189 with involvement of unusual anatomic sites. Cases in which the mode of spread included direct spread to the adjacent tissue and lymphovascular metastases were excluded. Medical history, including presenting symptoms, and follow-up data were obtained. RESULTS: Two cases of noninvasive @entity189 were identified. One had presented as an implant in the peritoneal investment of the bladder dome and the other as multiple implants growing on the benign surface of the colonic mucosa of an orthotopic neobladder distant from the @entity254 site. Both cases had initially presented as noninvasive @entity1377 of the @entity8 . Although the urinary bladder was free of neoplastic changes at nephroureterectomy, both @entity1 also developed several @entity5 within the bladder shortly after the removal of the kidney. CONCLUSIONS: After clinicopathologic correlation, the mode of @entity5 spread in these cases was best explained by the "seeding/implantation" theory. The @entity5 cells in each of these cases demonstrated the ability to implant themselves not only in the urothelium of the bladder but also in the colonic mucosa of a constructed neobladder and on the peritoneal surface.
