A single intracerebroventricular Ab25-35 infusion leads to prolonged alterations in @entity369 metabolism in the XXXX hippocampus and prefrontal cortex.

@entity7792 @entity8561 @entity3264 @entity1246 @entity8037 @entity7224 @entity5261 @entity10608 @entity195 @entity35 @entity13153 @entity369 @entity11667
While amyloid beta (Ab) plays a central role in the development of @entity195 ( @entity195 ), recent evidence suggests the involvement of @entity369 metabolism in @entity195 pathogenesis. Earlier research has shown that a single intracerebroventricular (i.c.v.) infusion of pre-aggregated Ab25-35 (the neurotoxic domain of the full-length Ab) altered @entity369 metabolism in the @entity35 hippocampus (particularly the @entity13153 and dentate gyrus (DG) sub-regions) and prefrontal cortex (PFC) at the time point of 8days post-infusion. The present study measured the levels of @entity8561 and its nine downstream metabolites ( @entity7792 , @entity10608 , @entity5261 , @entity7224 , @entity11667 , @entity8037 , @entity3264 , @entity1246 and @entity3264 ) in the hippocampus and PFC at the time points of 42 and 97days following a single bilateral i.c.v. infusion of Ab25-35 (30nmol/ @entity35 ) or Ab35-25 (reverse peptide; 30nmol/ @entity35 ). At the 42-day time point, Ab25-35 resulted in decreased levels of @entity3264 , @entity3264 and @entity8037 in the @entity13153 sub-region of the hippocampus. At the 97-day time point, however, there were decreased @entity10608 , @entity1246 and @entity7224 levels, but increased @entity3264 / @entity1246 ratio, in the PFC and increased @entity8037 levels in the DG sub-region. Cluster analyses showed that @entity8561 and its three main metabolites @entity7792 , @entity10608 and @entity5261 formed distinct groups, which changed as a function of Ab25-35 at the 42-day and 97-day time points, particularly in the @entity13153 and PFC regions respectively. This study, for the first time, demonstrates that a single i.c.v. infusion of pre-aggregated Ab25-35 leads to prolonged alterations in @entity369 metabolism in a region-specific and time-dependent manner, which further supports the involvement of @entity369 metabolism in @entity195 pathogenesis.
