Age-related changes in basal substrate oxidation and visceral adiposity and their association with XXXX .

@entity1 @entity10478 @entity412 @entity209 @entity1386
PURPOSE: Ageing is directly associated with @entity1386 ( @entity1386 ) deposition and decline of metabolically active cellular mass, which may determine age-related shifts in substrate oxidation and increased cardiometabolic risk. We tested whether @entity1386 and fasting respiratory quotient (RQ, an index of macronutrient oxidation) changed with age and if they were associated with increased risk of @entity209 ( @entity209 ). METHODS: A total of 2819 adult @entity1 (age range: 18-81 years; @entity1 / @entity1 : 894/1925) were included; we collected history, anthropometric measures, biochemistry, smoking habits, and physical activity. The body mass index range was 18.5-60.2  kg/m(2). Gas exchanges (VO2 and VCO2) were measured by indirect calorimetry in fasting conditions, and RQ was calculated. Body composition was measured by bioelectrical impedance. Abdominal subcutaneous fat and @entity1386 were measured by ultrasonography. @entity209 was diagnosed using harmonised international criteria. Multivariate linear and logistic regression models were utilised. RESULTS: @entity1386 increased with age in both @entity1 (r  =  0.31, p  <  0.001) and @entity1 (r  =  0.37, p  <  0.001). Basal RQ was not significantly associated with age (p  =  0.49) and @entity1386 (p  =  0.20); in addition, basal RQ was not a significant predictor of @entity209 (OR 3.31, 0.57-19.08, p  =  0.27). @entity1386 was the primary predictor of @entity209 risk in a fully adjusted logistic model (OR 4.25, 3.01-5.99, p  <  0.001). CONCLUSIONS: @entity10478 remains one of the most important risk factors for cardiometabolic risk and is a significant predictor of @entity209 . Post-absorptive substrate oxidation does not appear to play a significant role in age-related changes in body composition and cardiometabolic risk, except for a correlation with @entity412 concentration.
