Effect of Milk Powder Supplementation with Different @entity460 Contents on Bone Mineral Density of Postmenopausal XXXX in Northern China: A Randomized Controlled Double-Blind Trial.

@entity1 @entity604 @entity79 @entity460 @entity560
UNASSIGNED: The objective of this study is to examine the effect of milk powder supplementation with different @entity460 contents on @entity79 ( @entity79 ) in postmenopausal Chinese @entity1 , and to determine a more appropriate dose of @entity460 supplementation. A 2-year, randomized controlled double-blind trial. Postmenopausal @entity1 (n  =  210) aged 50-65  years were recruited and assigned randomly into three @entity460 supplementation groups. All @entity1 received milk powder supplementation with different @entity460 contents (300, 600, and 900  mg per day for groups A, B, and C, respectively) and all groups received 800  IU of @entity560 per day. During the follow-up period, @entity79 of the left hip and lumbar spine (as the main indicator) was measured using dual-energy X-ray absorptiometry at the baseline, 1 and 2  years. Both three @entity79 measures and the changes of @entity79 over 2  years were used to analyze. Before adjusting for covariates, @entity79 in group A of the lumbar spine and groups A and B of greater trochanter decreased significantly from the baseline over time but increased significantly in the rest groups of the lumbar spine and greater trochanter and in three groups of Ward's triangle. There were significant differences across the three groups for changes of @entity79 in the greater trochanter and Ward's triangle. When adjusting for covariates, there were significant decreases with time in group A of the spine (P  =  0.001), groups A and B of greater trochanter (P  =  0.0002 and P  =  0.04, respectively) and increases in groups B and C of Ward's triangle (P  =  0.03 and P  =  0.004, respectively). @entity79 change in the greater trochanter was significantly different among three groups. For healthy postmenopausal @entity1 , high @entity460 milk powder supplementation was better in retarding @entity604 than medium and low @entity460 in the greater trochanter. Considering the dietary @entity460 intake of postmenopausal @entity1 in north of China, a dose of 900  mg/day is considered as the most appropriate @entity460 supplementation for greater trochanter but not for other sites.
