Neuroimmune communication in the submucous plexus of XXXX colon after infection with @entity8416 .

@entity4444 @entity8416 @entity840 @entity56 @entity112 @entity934
BACKGROUND/AIMS: Enteric neuroimmune communication in gastrointestinal @entity56 responses includes antigen detection by mast cells and release of chemical messages to the enteric nervous system. The aim of this study was to analyze the electrical and synaptic behavior of neurons in the colonic submucous plexus during exposure to @entity8416 spiralis antigen in animals infected earlier with the parasite. METHODS: Microelectrodes were used to record in submucous neurons of @entity840 distal colon during application of @entity8416 antigen. RESULTS: Neurons in sensitized animals were more excitable than in controls. Hyperexcitability was seen as a greater probability of spontaneous action potential discharge and repetitive firing to depolarizing current or exposure to @entity934 . Application of histaminergic antagonists reversed the augmented excitability, suggesting endogenously released @entity112 as a responsible factor. Antigenic exposure increased neuronal excitability and suppressed nicotinic transmission at fast cholinergic synapses only in sensitized animals. Effects on excitability, but not presynaptic inhibitory effects, were blocked by @entity4444 . CONCLUSIONS: Signaling between mucosal mast cells and the enteric nervous system is involved in colonic anaphylactic responses to sensitizing antigens. @entity112 is a paracrine signal in the communication pathway.
