Angiogenesis and lymphangiogenesis in primary XXXX .

@entity3329 @entity66 @entity3217 @entity706 @entity5 @entity784 @entity14041 @entity1583 @entity5658 @entity272
UNASSIGNED: Primary @entity784 are a group of rare @entity1583 , derived from mature T lymphocytes and initially developing only in the skin. The most common @entity706 representing this group are @entity3217 fungoides and @entity14041 . @entity3217 fungoides is an @entity66 with a chronic course and characteristic evolution of the @entity272 from erythematous patches, through plaques to @entity5 . @entity14041 is characterized by an aggressive course and a triad of symptoms ( @entity5658 , generalized @entity3329 , and the presence of atypical cells in the skin, lymph nodes and peripheral blood). The etiopathogenesis of @entity706 is not fully understood, but a few studies on angiogenesis and lymphangiogenesis in these @entity5 indicate a significant role in their development and progression. Angiogenesis is a process of formation of new blood vessels from existing ones. Lymphangiogenesis is a similar process concerning lymphatic vasculature. Development of new vessels is a complex process composed of several successive stages: migration, proliferation, and differentiation of endothelial cells, extracellular matrix degradation and formation and stabilization of new vessels, regulated by growth factors, cytokines and other proteins. Both phenomena are essential in the development and progression of solid @entity5 and @entity1583 . Therapeutic strategies involving the inhibition of @entity5 angiogenesis and lymphangiogenesis are a promising new direction of studies in antitumor therapy, requiring further experiments.
