Microvessel count predicts @entity3 and survival in XXXX .

@entity1 @entity5 @entity1149 @entity3 @entity204
The growth of newly formed vessels, or neoangiogenesis, represents an important step in both physiological and pathological situations: in particular, @entity5 growth and @entity3 require angiogenesis. Microvessel count (MC), which represents a measure of @entity5 angiogenesis, has been associated with metastatic spread in cutaneous, mammary, prostatic, head and neck, and @entity5 . In this study, the role of @entity5 angiogenesis as a prognostic indicator was examined in 253 primary @entity1149 (NSCLC) @entity1 . Microvessels were counted by highlighting endothelial cells with anti-Factor VIII monoclonal antibody (Mab) in methacarn-fixed @entity5 samples. In univariat analysis, MC (P< 0.000001), sex (P=0.0036), histotype (P < 0.014), @entity5 status (P <0.007), and vessel invasion (P < 0.019) were significantly related to hilar and/or mediastinal nodal involvement. However, in the stepwise logistic regression analysis, MC (P<0.000003) retained the most important influence on nodal @entity3 . The overall survival analysis calculated by the Kaplan-Meier method revealed that @entity5 with high MC ( > 25 vessels/field) were significantly associated with @entity204 (log-rank test P = 0.00067; Cox's test P = 0.00046; Gehan's Wilcoxon test P = 0.00108). In 94 @entity1 , the development of @entity3 during follow-up was significantly related to MC. Indeed, @entity1 who developed @entity3 during follow-up showed a higher MC, either as a dichotomous (P = 0.01) or as a continuous (P = 0.003) variable, than @entity1 who had developed no @entity3 at the time of the analysis. Moreover, in the stepwise logistic regression analysis, MC retained the most important influence on distant metastases.(ABSTRACT TRUNCATED AT 250 WORDS)
