Association of XXXX and lower airway responsiveness in schoolchildren based on an epidemiological survey.

@entity1 @entity32 @entity2488 @entity565 @entity2490 @entity402 @entity2710
BACKGROUND/AIMS: We sought to increase our understanding of the @entity2490 relationship and improve strategies for the treatment of @entity1 with these diseases. The aim of this study was to identify a connection between upper airway @entity32 and lower airway responsiveness. METHODS: We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and @entity2710 challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The @entity2710 concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 < 25 mg/mL) was used as the threshold of @entity2488 ( @entity2488 ). RESULTS: In total, 26% of subjects had positive nasal eosinophils on a smear, and 46.2% of subjects had @entity2488 at < 25 mg/mL @entity2710 PC20. Nasal symptoms were higher in subjects with than without nasal eosinophils (p = 0.012). @entity565 symptoms did not differ between subjects with and without nasal eosinophils. Nasal eosinophils were higher in subjects with @entity402 than those without (p = 0.006), and there was no difference in PC20 @entity2710 according to @entity402 (15.5    1.07 vs. 17.5    0.62; p > 0.05). No difference in @entity2488 was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01    2.92 mg/mL vs. 17.38    0.61 mg/mL; p < 0.001). CONCLUSIONS: These findings demonstrated that @entity32 might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey.
