Systemic prophylaxis with XXXX ( @entity868 ) in elective surgery of the colon and rectum.

@entity1 @entity2868 @entity295 @entity868 @entity281 @entity86
The effect of @entity868 prophylaxis in elective colonic and rectal surgery was studied in a prospective double-blind trial in which @entity868 was compared with a placebo. Fifty-six @entity1 were included in the study, and the @entity1 were randomly allocated to the two groups. Twenty-five @entity1 received 2 gm of @entity868 the day before operation and 1.2 gm as a single daily dose for 5 days after operation. Twenty-one @entity1 were given placebos in the same dosage. Before operation all @entity1 were prepared with mechanical evacuation of the bowel. A significantly lower frequency of wound spesis, intraabdominal complications, and @entity295 was found in the @entity868 group as compared to the placebo group. The incidence was 4.0% and 36%, respectively. Following protectomy, @entity281 in the perineal area occurred in 33% and 43% of the respective groups. In the @entity868 -treated @entity1 , however, this was the only complication, whereas 50% of the @entity1 in the placebo group developed intraabdominal complications as well. After operation anaerobic bacteria were isolated from 8% of the @entity1 who received prophylactic @entity868 . In the control group 67% of the @entity1 had a positive postoperative anaerobic culture. @entity2868 was isolated from 13 of 14 @entity1 with @entity86 in the placebo group. @entity2868 was not isolated from any of the @entity868 -treated @entity1 . The study indicates that anaerobic bacteria are the major contributors to would @entity281 following colonic and rectal surgery and that @entity868 prophylaxis greatly reduces the frequency of @entity86 .
