Localized XXXX : an unrecognized entity.

@entity1 @entity548 @entity2783 @entity1581 @entity2590 @entity3052 @entity1582 @entity12884
Virtually all @entity1 who present with @entity548 and amyloid of the colon have evidence of @entity1582 and require therapy. The small subset of @entity1 with @entity2783 localized to the colon must be recognized and treatment avoided. We queried our file for @entity1 who had @entity2783 of the colon but no evidence of @entity1582 during long-term follow-up. We identified 3 @entity1 who presented with @entity548 and who, on investigation, had @entity12884 but no evidence of @entity1582 during a follow-up of 4.5 to 20 years. These @entity1 had no evidence of a @entity1581 and received no chemotherapy to prevent deposition of amyloid. It is important to recognize this rare subset and avoid treatment with alkylating agents or high-dose therapy followed by autologous stem cell transplantation. Alkylating agent therapy may be associated with @entity2590 or @entity3052 . In addition, the cost, inconvenience, and morbidity of therapy are avoided by observation. @entity1 who present with @entity548 and a subsequent diagnosis of @entity2783 of the colon likely will be subjected to chemotherapy or transplantation. Such @entity1 must be recognized and treatment avoided if there is no evidence of @entity1582 because they remain stable for many years.
