Association of subclinical XXXX using carotid @entity121 , carotid plaque, and coronary @entity460 score with left ventricular dyssynchrony: the multi-ethnic Study of @entity731 .

@entity1 @entity296 @entity714 @entity2998 @entity25346 @entity460 @entity731 @entity121 @entity65 @entity1002
BACKGROUND: The role of @entity731 in the progression of @entity1002 and @entity65 has been well recognized. @entity1002 is a measure of regional @entity296 . Our objective was to investigate the relationship of subclinical @entity731 with mechanical @entity1002 in a population-based asymptomatic multi-ethnic cohort. METHODS AND RESULTS: @entity1 of the Multi-Ethnic Study of @entity731 (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n = 2062) for common carotid artery (CCA) and internal carotid artery (ICA) @entity121 ( @entity121 ), and cardiac computed tomography (n = 2039) for coronary artery @entity460 (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices * 4 segments). Multivariable regression analyses were performed to assess associations after adjusting for @entity1 demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of @entity731 , including @entity2998 (8.7 ms/mm change in @entity121 , p = 0.020), @entity2998 (19.2 ms/mm change in @entity121 , p < 0.001), carotid plaque score (1.2 ms/unit change in score, p < 0.001), and log transformed @entity25346 (0.66 ms/unit log- @entity25346 , p = 0.018). These findings were consistent with other parameter of @entity1002 i.e. max-min. CONCLUSION: In the MESA cohort, measures of @entity731 are associated with parameters of subclinical @entity1002 in the absence of clinical coronary event and @entity714 .
