THE SYNTHESIS, STORAGE, AND EXCRETION OF XXXX , @entity1011 , AND GLYCOCYAMINE IN PROGRESSIVE MUSCULAR DYSTROPHY AND THE EFFECTS OF CERTAIN HORMONES ON THESE PROCESSES.

@entity1 @entity3033 @entity908 @entity3986 @entity5498 @entity8147 @entity8645 @entity1011 @entity121
The diminished excretion of @entity1011 in @entity3986 is a more striking and specific phenomenon than the excess excretion of @entity908 , marked though this is. While creatinuria is invariably encountered in all cases of @entity3986 , the extent to which the excretion of @entity1011 is decreased provides a more reliable indication of the severity of the disease since an excess output of @entity908 may occur physiologically in normal @entity1 subjects and in many pathological conditions not known to be associated with @entity121 . In @entity3986 the residual muscle mass, as inferred from the excretion of @entity1011 , provides a useful index of the state of the disease at any given time. Although there is excessive creatinuria in @entity3986 , there is no evidence that a deprivation of @entity5498 stores occurs through a loss of urinary @entity908 . The loss of @entity5498 groups contained in the excess @entity908 is, under ordinary conditions of diet, almost exactly compensated for by a drop in the excretion of @entity5498 groups in the urinary @entity1011 . @entity3033 , administered over variable periods of time, resulted in the retention of @entity908 both in normal male @entity1 and in male @entity1 with @entity3986 , as shown in the normal subjects by a diminution in @entity908 output, and in both by an excess creatinuria for variable periods of time following withdrawal of the hormone. An increase in the excretion of @entity908 in @entity3986 occurred following the administration of @entity8645 . Neither @entity3033 nor @entity8645 appeared to effect any consistent change in the output or urinary @entity1011 . No effects on the excretion of @entity908 and @entity1011 were observed following the prolonged administration of concentrate of gonadotropic and thyrotropic principles of the hypophysis, or from the administration of @entity8147 to @entity1 with @entity3986 . Except in one case, in which marked improvement was observed following the administration of @entity3033 , no effects on the clinical course of the @entity1 with @entity3986 were observed as a result of treatment by any of the various hormones employed in this study.
