Comparison of different equations to assess glomerular filtration in @entity3124 XXXX .

@entity1 @entity9649 @entity8 @entity470 @entity3124 @entity740
PURPOSE: To evaluate equations for estimation of glomerular filtration rate (GFR) and measured urinary creatinine clearance, compared to measured GFR in @entity3124 @entity1 . METHODS: GFR was measured using inulin clearance. Multiple blood samples were collected per @entity1 for determination of serum creatinine, @entity9649 and inulin. GFR was estimated by the use of the following estimation equations ( @entity470 ): four commonly used creatinine-based equations [Cockcroft-Gault, Modification of Diet in @entity8 (both the short and long formula) and @entity740 Epidemiology Collaboration (CKD-EPI)], five @entity9649 based estimation equations (Hoek, Larsson, Filler, Le Bricon, CKD-EPIcys) and one equation combining @entity9649 and serum creatinine (CKD-EPIcr-cys). In addition we measured urinary creatinine clearance. Bias, precision and accuracy of all estimates were compared to those of the inulin clearance. RESULTS: Data were collected from 83 @entity1 , of whom 68 were considered evaluable. The median age was 58  years [interquartile range (IQR) 39-68]. The median inulin clearance was 80  mL/min/1.73  m(2) (IQR 31-114). Equations based on creatinine had much bias and poor precision and accuracy. Measured urinary creatinine clearances overestimated GFR. Equations based on @entity9649 were free of bias, but also had limited precision and accuracy. CONCLUSIONS: In this cohort of @entity1 , estimates of GFR had low accuracy and precision. @entity9649 based formulas, especially CKD-EPIcr-cys, showed limited bias; however, the accuracy and precision of these estimates were still insufficient. Measured urinary creatinine clearance overestimates GFR, but may provide a cheap alternative, when this is taken into account.
