Novel gradient echo sequence  -based XXXX proton transfer magnetic resonance imaging in hyperacute @entity385 .

@entity64 @entity2806 @entity3145 @entity63 @entity2500 @entity8193 @entity520 @entity1188 @entity880 @entity35 @entity6346 @entity385
UNASSIGNED: In the progression of @entity63 , pH is important and is essential in elucidating the association between metabolic disruption, @entity880 formation, @entity520 and @entity3145 . Chemical exchange  -dependent saturation transfer (CEST) imaging can be used to detect tissue pH and, in particular, a specific form of CEST magnetic resonance imaging  (MRI), termed @entity6346 proton transfer (APT) MRI, which is sensitive to pH and can detect @entity2806 , even prior to diffusion abnormalities. The critical parameter governing the ability of CEST to detect pH is the sequence. In the present study, a novel strategy was used, based on the gradient echo sequence (GRE), which involved the insertion of a magnetization transfer pulse in each repetition time (TR) and minimizing the TR for in  vivo APT imaging. The proposed GRE  -APT MRI method was initially verified using a tissue  -like pH phantom and optimized MRI parameters for APT imaging. In order to assess the range of acute @entity385 , @entity35 (n=4) were subjected to @entity2500 ( @entity2500 ) and MRI scanning at 7  telsa  (T). Hyperacute @entity63 @entity3145 was characterized using multiparametric imaging techniques, including diffusion, APT and T2  -Weighted MRI. By using a magnetization transfer pulse and minimizing TR, GRE  -APT provided high spatial resolution and a homogeneous signal, with clearly distinguished cerebral anatomy. The GRE  -APT and diffusion MRI were significantly correlated with @entity880 content and the area of @entity385 in the APT and apparent diffusion coefficient  (ADC) maps matched consistently during the hyperacute period. In addition, compared with the @entity1188 area observed on the ADC MRI map, the APT map contained tissue, which had not yet been irreversibly damaged. Therefore, GRE  -APT MRI waa able to detect @entity63 @entity8193 with sensitivity and spatiotemporal resolution, suggesting the potential use of pH MRI as a surrogate imaging marker of impaired tissue metabolism for the diagnosis and prognosis of hyperacute @entity64 .
