Long-term predictive value of postsurgical @entity701 concentrations for cure and risk of recurrence in XXXX .

@entity1 @entity1104 @entity701 @entity699
We assessed the value of postoperative plasma @entity701 concentrations to predict cure and recurrence of @entity699 after @entity1104 ( @entity1104 ). Seventy-eight of 80 consecutive @entity1 treated by @entity1104 for @entity699 were evaluated. @entity1104 cured 72% (n = 56) of the @entity1 . Two weeks after surgery, @entity1 with plasma @entity701 levels below 138 nmol/liter (n = 50; three macroadenomas) and eight (27%) of 30 @entity1 (nine macroadenomas) with @entity701 greater than 138 nmol/liter were cured. Six (five with a macroadenoma) of these eight @entity1 had @entity701 values less than 50 nmol/liter 3 months after surgery. Therefore, the optimal cut-off value of @entity701 predicting remission was 138 nmol/liter, measured 3 months after surgery (positive and negative predictive values 87 and 90%, respectively). Five @entity1 (9%) had recurrent @entity699 during a median follow-up of 7 yr. Recurrence occurred in four of 24 (17%) @entity1 with a follow-up of more than 10 yr. Therefore, @entity701 levels above 138 nmol/liter, obtained 2 wk after @entity1104 , should be repeated, because they do not predict persistent @entity699 in 27% of those @entity1 . Postoperative @entity701 levels do not positively predict recurrence of disease during long-term follow-up of initially cured @entity1 .
