Influence of @entity55 on the prognosis of @entity1 with autopsy-confirmed @entity195 , @entity1832 , and XXXX .

@entity1 @entity6 @entity55 @entity303 @entity1294 @entity1832 @entity195 @entity204
BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .
