Antiepileptic drug use for treatment of XXXX and dyslipidemia: Systematic review.

@entity1 @entity455 @entity1092 @entity412 @entity302 @entity3174 @entity2049 @entity165
OBJECTIVE: To characterize the association between commonly used @entity302 ( @entity302 ) and plasma lipid levels in @entity1 with @entity302 . METHODS: We sought observational studies that reported association between commonly used @entity302 and plasma lipid levels in @entity1 . The primary outcome was low-density lipoprotein (LDL) @entity165 . High-density lipoprotein (HDL), total @entity165 and @entity412 were secondary outcomes. The control group included healthy controls, pre-treatment @entity1 or @entity1 treated with other @entity302 . We conducted a systematic search of major bibliographic databases and review of reference lists of primary articles and reviews. Primary comparisons of interest were: AED monotherapy vs. no AED use, monotherapy with one AED vs. other AED, and AED polytherapy vs. no AED use. RESULTS: 31 studies in 4126 @entity1 were identified. @entity2049 , @entity3174 and @entity1092 were the most commonly studied drugs and were also implicated in causing considerable changes in plasma lipid levels in treated @entity1 . There was an increase in LDL and total @entity165 levels with use of these three drugs; however, @entity2049 and @entity3174 were also associated with higher levels of HDL. We could not identify one particular AED which was worse than the other in head-to-head comparison. We were unable to identify a particular polytherapy regimen that was worse than others. CONCLUSION: We found evidence to suggest that some @entity302 may negatively alter lipids levels in @entity1 with @entity302 . Both treating physicians and @entity1 with @entity302 need to be vigilant in managing their vascular risk factors to avoid @entity455 .
