Dermal and ocular exposure systems for the development of models of XXXX mustard-induced injury.

@entity1 @entity840 @entity95 @entity4858 @entity599 @entity130
@entity599 mustard (SM) is a chemical threat agent for which the effects have no current treatment. Due to the ease of synthesis and dispersal of this material, the need to develop therapeutics is evident. The present article details the techniques used to develop SM laboratory exposure systems for the development of animal models of ocular and @entity130 . These models are critical to enable evaluation of @entity130 and therapeutics against that injury. Iterative trials were conducted to optimize dermal and @entity4858 models in @entity840 and @entity95 respectively. The goal was a homogeneous and diffuse ocular and @entity130 that compares to the @entity1 injury. Dermal exposures were conducted by either a flow-past or static vapor cup system. Ocular exposures were conducted by a static exposure system. Ocular and dermal exposures were conducted with vaporized SM. Vapor concentrations increased with time in the dermal and ocular exposure systems but were stable with varying amounts of applied SM. A dermal deposition estimation study was also conducted. Deposited volumes increased with exposure time.
