9C.09: TREATMENT WITH XXXX UNMASKS HIGHER URINARY NOREPINEPHRINE EXCRETION IN WHITE COAT HYPERTENSIVE @entity1 COMPARED TO HEALTHY NORMOTENSIVE @entity1 .

@entity1 @entity19430 @entity6531 @entity101 @entity916 @entity1564 @entity44950 @entity1063 @entity15
OBJECTIVE: White coat @entity101 is a pre- @entity101 state that has been associated with increased sympathetic drive. The objective of the study was to compare the exposure of the kidney to sympathetic nerve activity using urinary @entity6531 (UNMN) as a marker of renal sympathetic exposure in @entity19430 ( @entity19430 ) and healthy normotensive (HN) @entity1 . DESIGN AND METHOD: This was a double-blind randomized placebo-controlled crossover study. @entity19430 were included if office blood pressure was >140/80 mmHg and ambulatory blood pressure <135/85 mmHg and HN if @entity44950 was <140/90 mmHg and ABP <135/85 mmHg @entity1 were randomized to receive either 16mg of @entity1564 or a matched placebo for one week before study day. On the study day systemic and renal hemodynamics as well as plasma @entity1063 and urinary excretion of @entity6531 (measured by LC/ @entity15 - @entity15 were measured after one hour of baseline, one hour of lower body negative pressure and one hour of recovery period. Excretion of UNMN was expressed as the total of UNMN excreted during these three hours (cumUNMN). Paired or unpaired t-test were used for comparison. RESULTS: 25 HN and 12 @entity19430 @entity1 were included in the study. Mean age (  standard deviation), BMI were respectively 31.0  10.5 years and 22.0  2.2Kg/m2 in HN and 40.7  17.8 years and 26.7  6.3Kg/m2 in @entity19430 .Table 1 Baseline mean blood pressure, plasma @entity1063 and cumulated UNMN during placebo and @entity1564 (Figure is included in full-text article.)Mean blood pressure was higher during placebo and @entity1564 in @entity19430 compared to HN. Cumulated UNMN was higher in both groups after @entity1564 treatment. Cumulated UNMN was higher in @entity19430 than in HN only after @entity1564 treatment. CONCLUSIONS: Urinary excretion of @entity6531 is increased in @entity19430 compared to HN when treated with @entity1564 . The increased excretion of uNMN when the @entity916 angiotensin system is blocked might reflect an increased sensitivity of @entity19430 to stress conditions such as orthostatic stress.
