@entity13805 and @entity10022 alleviate endoplasmic reticulum stress and improve prognosis of donation after XXXX liver transplantation in @entity35 .

@entity13805 @entity21206 @entity7599 @entity12381 @entity63 @entity14030 @entity21205 @entity409 @entity12382 @entity10022 @entity37735 @entity1234 @entity6061 @entity224 @entity35 @entity204
BACKGROUND: Inevitable warm @entity63 time before organ procurement aggravates posttransplantation @entity63 -reperfusion injury. Endoplasmic reticulum (ER) stress is involved in @entity63 -reperfusion injury, but its role in donation after @entity204 ( @entity6061 ) liver transplantation is not clear and the effect of ER stress inhibitors, @entity13805 ( @entity13805 ) and @entity10022 ( @entity14030 ), on the prognosis of recipient of @entity6061 liver transplantation remains unclear. METHODS: Male @entity35 (8-10 weeks) were randomly divided into the control group: liver grafts without warm @entity63 were implanted; @entity6061 group: warm @entity63 time of the liver grafts was 60 minutes; @entity13805 and @entity14030 groups: based on the @entity6061 group, donors were intraperitoneally injected with @entity13805 or @entity14030 30 minutes before the organ procurements. Serum aminotransferase levels, oxidative stress activation and expression of ER stress signal molecules were evaluated. Pathological examinations were performed. The survivals of the recipients in each group were compared for 14 days. RESULTS: Compared with the control group, @entity6061 @entity35 had significantly higher levels of serum aminotransferase at 6 hours, 1 day and 3 days after operation (P<0.01, 0.01 and 0.05, respectively) and oxidative indices (P<0.01 for both @entity1234 and @entity7599 ), more severe @entity409 (P<0.01) and up-regulated ER stress signal expressions (P<0.01 for @entity21205 , phos-eIF2alpha1, @entity21206 , @entity12382 , @entity37735 , PERK, @entity12381 and pro-caspase-12). All recipients died within 3 days after liver transplantation. Administration of @entity13805 or @entity14030 significantly decreased aminotransferase levels (P<0.05), increased @entity224 dismutase activities (P<0.01), alleviated @entity409 (P<0.01), down-regulated ER stress signal expressions (P<0.01) and improved postoperative survivals (P<0.01). CONCLUSIONS: ER stress was involved with @entity6061 liver transplantation in @entity35 . Preoperative intraperitoneally injection of @entity13805 or @entity14030 protected ER stress and improved prognosis.
