Inspiratory muscle strength is a determinant of maximum XXXX consumption in @entity712 .

@entity1 @entity712 @entity26 @entity425 @entity2507
OBJECTIVE: To investigate the significance of @entity425 in @entity712 and its relation both to maximum @entity26 consumption during cardiopulmonary exercise testing and to skeletal muscle (quadriceps) strength. SUBJECTS: Seven healthy @entity1 aged 54.9 (SEM 4.3) years and 20 @entity1 with @entity712 aged 61.4 (1.6) years (P = 0.20) with radionuclide left ventricular ejection fraction of 25.4 (3.0)%. METHODS: Mouth pressures during maximum static inspiratory effort (PImax) at functional residual capacity (FRC) and residual volume (RV) were measured in all subjects and taken as indices of inspiratory muscle strength. Similarly, mouth pressures during maximum static expiratory effort (PEmax) at FRC and total lung capacity (TLC) were taken as indices of expiratory muscle strength. Cardiopulmonary exercise testing was performed in all subjects. All controls and 15 @entity712 @entity1 also had their right quadriceps muscle strength measured. RESULTS: There was @entity425 in @entity712 @entity1 , with reduction of PImax at FRC (59.7) (6.3) v 85.6 (9.6) cm @entity2507 , P = 0.045), PEmax at FRC (94.8 (6.2) v 134.6 (9.1) cm @entity2507 , P = 0.004), and PEmax at TLC (121.7 (8.5) v 160.7 (13) cm @entity2507 , P = 0.028). PImax at RV was also reduced but this did not reach statistical significance (77.3 (6.6) v 89.3 (13) cm @entity2507 , P = 0.44). There was also significant @entity425 (308.5 (22) v 446.2 (28) N, P = 0.001). PImax at both FRC and RV correlated with maximum @entity26 consumption (r = 0.59, P = 0.006, and r = 0.45, P = 0.048 respectively) but not PEmax. There was, however, no significant correlation between PImax and right quadriceps strength. CONCLUSIONS: Respiratory @entity425 is seen in @entity712 . The results suggest that inspiratory muscles are important in determining maximum @entity26 consumption and exercise tolerance in these @entity1 . The lack of correlation between respiratory and right quadriceps muscle strength further suggests that the magnitude and time course of @entity425 may differ in individual @entity1 . Treatment aimed at improving the function of the involved muscle groups may alleviate symptoms.
