@entity6927 -antitrypsin phenotypes, including M subtypes, in @entity358 associated with @entity309 and XXXX .

@entity1 @entity82 @entity627 @entity3794 @entity358 @entity309 @entity6927 @entity785
@entity6927 -antitrypsin is a glycoprotein that functions as the major protease inhibitor in human serum. Many genetic variants of @entity6927 -antitrypsin can be detected by electrophoretic techniques. We used isoelectric focusing on ultrathin gels to determine the common M subtypes as well as other variants of @entity6927 -antitrypsin in 62 white @entity1 with @entity309 ( @entity309 ) and 51 white @entity1 with @entity785 ( @entity785 ). We found no increased prevalence of variant phenotypes in either disease group as a whole. In @entity309 , however, the association between @entity3794 and @entity6927 -antitrypsin variants was striking. Interstitial @entity82 was seen on chest roentgenogram in only 1 of 30 subjects apparently homozygous for M1 (the "wild type" or "normal" phenotype), compared with 13 of 32 @entity1 with variant phenotypes. Seven of 15 @entity1 with M1M2 (the most common variant phenotype) had @entity3794 . In contrast, there was no apparent association of variant phenotypes with @entity358 in @entity785 . Our findings suggest a possible role of @entity6927 -antitrypsin in the pathogenesis of @entity82 in @entity1 with @entity309 . The absence of such an association in @entity785 suggests that @entity358 in these 2 @entity627 may have different pathogeneses.
