Leukocytes mediate XXXX remodeling during development and vaso-obliteration in disease.

@entity1018 @entity2479 @entity63 @entity26 @entity23975 @entity989 @entity35 @entity11265 @entity1590
@entity2479 can cause vision-threatening pathological neovascularization. The mechanisms of @entity2479 are not fully understood, however. Here we have shown that leukocytes prune the retinal vasculature during normal development and obliterate it in disease. Beginning at postnatal day 5 (P5) in the normal @entity35 , vascular pruning began centrally and extended peripherally, leaving behind a less dense, smaller-caliber vasculature. The pruning was correlated with @entity989 expression of @entity1590 ( @entity1590 ) and coincided with an outward-moving wave of adherent leukocytes composed in part of cytotoxic T lymphocytes. The leukocytes adhered to the vasculature through @entity11265 and remodeled it through @entity23975 ( @entity23975 )-mediated endothelial cell apoptosis. In a model of @entity26 -induced @entity63 , this process was exaggerated. Leukocytes used @entity11265 and @entity23975 to obliterate the retinal vasculature, leaving behind large areas of @entity63 retina. In vitro, T lymphocytes isolated from @entity26 -exposed neonates induced a @entity23975 -mediated apoptosis of hyperoxygenated endothelial cells. Targeting these pathways may prove useful in the treatment of @entity2479 , a leading cause of @entity1018 .
