@entity205 nephrotoxicity in the Fischer XXXX .

@entity410 @entity67203 @entity1219 @entity425 @entity205 @entity1986 @entity35
Male Fischer @entity35 received daily intraperitoneal injections of @entity205 (IV preparation containing CsA + @entity67203 ) diluted in @entity1219 or in @entity1219 + @entity67203 . At the dose of 100 mg and 50 mg/kg/day the animals developed @entity410 , @entity425 and died at 4-7 days. Light microscopy at 7 days in these @entity35 showed diffuse vacuolization of all segments of the proximal tubules which was very extensive in the outer stripe. At the dose of 25 mg and 15 mg/kg/day animals were free of symptoms and were sacrificed at day 15 for functional and histological studies. Light and electron microscopy showed cytoplasmic vacuolization in all segments of the proximal tubules. Crystal structures were observed in the experimental animals as well as in the control group that received @entity67203 + @entity1219 . The CsA blood levels were at the range of 134-236 ng/ml. Reduction of the glomerular filtration rate was observed in experimental animals as compared with the controls. We concluded that CsA is not the cause of an @entity1986 in the Fischer @entity35 and that CsA is nephrotoxic to all segments of the proximal tubules. The @entity67203 is the cause of the crystal structures seen in the proximal tubules.
