Inhibitory effect of the ovaries on neonatal @entity342 imprinting of growth hormone secretion in female XXXX .

@entity3033 @entity2338 @entity251 @entity53 @entity342 @entity35
The effect of neonatal @entity342 treatment on the @entity2338 secretory pattern was examined in intact and ovariectomized adult female @entity35 . Neonatal ovariectomy or sham operation was performed at 1-2 days of age; thereafter, the animals were immediately given @entity3033 (250 micrograms) or vehicle. Other @entity35 , also treated neonatally with @entity251 , were ovariectomized 15-22 days before blood sampling. Plasma @entity2338 was measured in blood samples obtained from indwelling intraatrial cannulae every 20 min for 8 h when the animals were 100-140 days old. Plasma @entity2338 secretory patterns were analyzed by a pulse analysis computer program (PULSAR). Neonatal @entity251 treatment did not affect the @entity2338 secretory pattern of female @entity35 with intact ovaries. In contrast, neonatal @entity342 treatment enhanced @entity2338 pulse height as well as mean @entity2338 concentration in neonatally ovariectomized female @entity35 to levels comparable to those in intact male @entity35 . Neonatal @entity251 administration also significantly increased @entity2338 pulse height and mean plasma @entity2338 concentration in female @entity35 that were ovariectomized during adulthood. However, the @entity2338 secretory pattern of ovariectomized female @entity35 given @entity251 neonatally still differed markedly from that of normal males, in that @entity2338 pulses occurred less regularly and baseline levels were higher. Pituitary @entity2338 content and concentration in neonatally ovariectomized female @entity35 were increased to levels indistinguishable from those in male @entity35 by neonatal @entity251 treatment. No significant effect of neonatal @entity251 was observed in sham-operated females. Neonatal ovariectomy decreased basal plasma @entity2338 levels, but did not affect plasma @entity2338 pulse height or pituitary @entity2338 levels. The serum @entity53 concentration was markedly decreased in ovariectomized female @entity35 , but was unchanged in sham-operated @entity35 given neonatal @entity251 , raising the possibility that serum @entity53 secretion mediated the antagonistic effect of the ovaries on neonatal @entity342 imprinting. These results indicate that the presence of ovaries can prevent the stimulatory effect of neonatal @entity342 exposure on @entity2338 storage and secretion in adult female @entity35 .
