Rates of progression in @entity73 and early XXXX .

@entity303 @entity73 @entity204 @entity195
OBJECTIVE: To compare rates of progression in the very mildest stages of @entity195 , including the stage currently identified as @entity73 ( @entity73 ), and to identify predictors of those rates. METHODS: Demented (n = 289) and nondemented (n = 230) individuals enrolled in longitudinal studies at an @entity195 Research Center received annual clinical and psychometric examinations for up to 20 years. In order of increasing @entity303 severity, demented individuals were diagnosed with incipient, very mild, or mild @entity303 ; the incipient stage is equivalent to @entity73 . Outcome measures included @entity204 , nursing home placement, and psychometric scores. RESULTS: Rate of progression increased with @entity303 severity as staged by the Clinical @entity303 Rating at entry into the study. With respect to the dichotomous outcomes, the increase with @entity303 severity was more dramatic for the endpoint of nursing home entry than it was for the endpoint of @entity204 . Increased rates of @entity73 with increased @entity303 severity were also obtained for psychometric scores. There was limited evidence of other predictors of progression. CONCLUSIONS: The lack of effective predictors of the rate of @entity303 progression extends to the very earliest stages of the disease, including what is often called @entity73 . A new approach to the identification of correlates of rates of progression is needed.
