Topical XXXX enhances healing of thoracic aortic @entity254 for @entity1498 in a @entity95 model.

@entity1 @entity82 @entity254 @entity95 @entity730 @entity519 @entity1498 @entity1655 @entity2701 @entity94 @entity850
BACKGROUND: Recurrent @entity850 after extended end-to-end @entity254 for @entity1498 is the primary indication for further interventions in @entity1 . Tension because of the extended resection and local arterial wall @entity519 are possible pathogenetic mechanisms. We hypothesized that (1) @entity2701 interferes with healing and (2) that @entity94 ( @entity94 ), a @entity519 sensitive angiogenic inducer, may enhance healing of the vascular @entity254 . METHODS AND RESULTS: In a model of @entity1498 repair, @entity95 underwent thoracic aortic end-to-end @entity254 after transection (no- @entity2701 ; n=15), resection of an aortic ring ( @entity2701 ; n=14) or resection and topical @entity94 treatment (0.75 microg @entity1655 ; @entity2701 + @entity94 ; n=14). Gross and histologic characteristics of the aortic wall were assessed at 1 week, 1 and 2 months. In the @entity2701 only group at 1 month, the severity of vascular remodeling was increased with @entity82 and @entity730 compared with controls. At 2 months, this group also revealed @entity850 (29% versus 19%; P<0.001). Exogenous @entity94 resulted in significantly less @entity82 , @entity730 and chondroid metaplasia at 1 month (P<0.05) and luminal area was only reduced 3% at 2 months (P<0.001 versus @entity2701 group). CONCLUSIONS: In a @entity95 model of @entity1498 repair, the addition of @entity2701 on the vascular @entity254 resulted in poor healing and luminal @entity850 . Topical @entity94 maintained luminal integrity by decreasing @entity82 and @entity730 . These findings suggest that topical @entity94 may be a promising new strategy to enhance healing and improve the outcome of vascular anastomoses for @entity1498 .
