Probable Interaction Between XXXX and Banana Flakes Supplement.

@entity1 @entity2067 @entity294 @entity49 @entity5274 @entity2489 @entity2259 @entity1229
PURPOSE: To describe a case of subtherapeutic international normalized ratio (INR) associated with concomitant use of @entity1229 and banana flakes in a @entity1 with @entity294 . SUMMARY: A @entity1 in his 30s was hospitalized for an elective procedure, but his stay was complicated by @entity49 requiring intravenous infusion of unfractionated heparin, @entity2489 , @entity2259 requiring broad-spectrum antimicrobials and percutaneous @entity5274 , and @entity294 . Eventually, the heparin was transitioned to @entity1229 . After several days of therapeutic INR, the INR became subtherapeutic and remained so for 3 days. The decreased INR correlated temporally with initiation of consistent administration of dried banana flakes to treat @entity294 and the subsequent decrease in the rate and extent of @entity294 . @entity294 decreases the amount and activity of @entity2067 -producing intestinal flora and dietary @entity2067 absorption, resulting in increased INR. Resolution of @entity294 secondary to banana flakes administration in this @entity1 may have contributed to the decreased INR by causing a relative increase in @entity2067 -producing flora and @entity2067 absorption. A probability score of 5 was obtained upon applying the Drug Interaction Probability Scale modified to address interactions between @entity1229 and dietary supplements, indicating a probable interaction between @entity1229 and banana flakes. CONCLUSION: Concomitant use of @entity1229 and banana flakes supplements may result in a reduced rate and extent of @entity294 and may be associated with subtherapeutic INR and decreased @entity1229 efficacy. Practitioners must be aware of this potential interaction and closely monitor INR and adjust @entity1229 doses accordingly.
