Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after XXXX in @entity215 .

@entity1 @entity712 @entity1165 @entity215 @entity338 @entity204 @entity5778
AIMS: The right ventricle (RV) remodels early after @entity338 ( @entity338 ) in @entity215 ( @entity215 ) @entity1 . Previously reported preoperative thresholds to achieve early postoperative RV normalization were consistently close to 80 mL/m(2) for end-systolic volume ( @entity5778 ) and 160 mL/m(2) for end-diastolic volume (EDV). Our objective was to determine whether these thresholds were also associated with mid-to-late RV normalization and clinical events. METHODS AND RESULTS: Out of a multicentre cohort of 157 @entity215 @entity1 who had undergone @entity338 , in 65 @entity1 (62% male, age 29    8 years, homograft in 98%) cardiovascular magnetic resonance (CMR) imaging was performed preoperatively and >3 years (6.3 years, interquartile range: 4.9-9.5) postoperatively. Mid-to-late haemodynamic outcome was classified as: 'RV normalization' [RV ejection fraction (EF) > 48% and RV EDV < 108 mL/m(2)] in 14 of 65 (22%) @entity1 , 'intermediate' in 34 of 65 (52%) @entity1 , and 'suboptimal' (RV EF < 45% and RV EDV > 120 mL/m(2)) in 17 of 65 (26%) @entity1 . Preoperative RV @entity5778 < 80 mL/m(2) was strongly associated with favourable mid-to-late haemodynamic outcome in a proportional odds model [common odds ratio (OR): 0.04 for worse class, 95% confidence interval (CI): 0.01-0.17]. During 7.8    4.0 years follow-up after @entity338 , adverse clinical events ( @entity204 , sustained @entity1165 , or @entity712 ) occurred in 18 of 106 (17%) @entity1 with preoperative CMR available. @entity1 with preoperative RV @entity5778 > 95 mL/m(2) were at increased risk for unfavourable mid-to-late haemodynamic outcome (common OR: 25.5, 95% CI: 5.35-122) and events (hazard ratio: 2.89, 95% CI: 1.03-8.11). CONCLUSION: In @entity215 @entity1 who had undergone @entity338 , the best preoperative threshold to achieve mid-to-late RV normalization was RV @entity5778 < 80 mL/m(2). @entity1 with preoperative RV @entity5778 > 95 mL/m(2) were at increased risk for suboptimal haemodynamic outcome and adverse clinical events. Our findings may assist in timing of @entity338 .
