XXXX associated with severe @entity4988 : a comparison of a peptide-based chemically defined diet and standard enteral alimentation.

@entity1 @entity7493 @entity2313 @entity4988 @entity294
To demonstrate a relationship between diarrheal incidence and the onset of @entity4988 developing as a result of acute @entity7493 and severe catabolism, we initially studied two @entity1 who had developed severe @entity4988 (less than 2.5 g/dl) and @entity294 on a variety of enteral diets. Each @entity1 was placed on a peptide enteral formula at a rate of infusion equivalent to that used during the previous 24 h. Diarrheal volumes decreased significantly from greater than 1500 to less than 100 ml/day and from greater than 4000 to 800 ml/day. We subsequently studied 12 @entity1 in a randomized, prospective fashion to confirm our previous observations. Seven @entity1 received a peptide enteral formula, and five received a standard isotonic enteral formula as a control. The @entity1 were monitored for a minimum of 2 wk or until serum @entity2313 levels reached 3 g/dl. Nutritional variables were measured initially and every 4 days for the duration of the study. Of the @entity1 receiving the isotonic feeding, only one of five completed the study period without @entity294 . Two @entity1 died unrelated to the feeding, and three @entity1 developed severe @entity294 within 48 h of institution of the study. Of the seven @entity1 receiving the peptide feeding, six completed the study period without @entity294 . One @entity1 had a large stool volume initially which decreased by day 2 of the study. We conclude that a peptide enteral formula is well tolerated in @entity1 with severe @entity4988 when compared to a standard isotonic enteral formula. The ability to provide enteral nutrition in a form that is well tolerated in @entity4988 @entity1 may obviate the need for parenteral nutrition routinely in these @entity1 .
