Assessment of estimated retinal atrophy progression in XXXX using spectral-domain optical coherence tomography.

@entity1 @entity21104 @entity6 @entity1020 @entity24816
AIMS: To estimate disease progression based on analysis of macular volume measured by spectral-domain optical coherence tomography (SD-OCT) in @entity1 affected by @entity1020 ( @entity24816 ) and to evaluate the influence of software errors on these measurements. METHODS: 58 eyes of 29 @entity24816 @entity1 were included. Numbers and types of algorithm errors were recorded and manually corrected. In a subgroup of 36 eyes of 18 @entity1 with at least two examinations over time, total macular volume ( @entity21104 ) and volumes of all nine Early Treatment of @entity6 Study (ETDRS) subfields were obtained. Random effects models were used to estimate the rate of change per year for the population, and empirical Bayes slopes were used to estimate yearly decline in @entity21104 for individual eyes. RESULTS: 6958 single B-scans from 190 macular cube scans were analysed. 2360 (33.9%) showed algorithm errors. Mean observation period for follow-up data was 15   months (range 3-40). The median (IQR) change in @entity21104 using the empirical Bayes estimates for the individual eyes was -0.103 (-0.145, -0.059) mm(3) per year. The mean (  SD) @entity21104 was 6.321  1.000   mm(3) at baseline, and rate of decline was -0.118   mm(3) per year (p=0.003). Yearly mean volume change was -0.004   mm(3) in the central subfield (mean baseline=0.128   mm(3)), -0.032   mm(3) in the inner (mean baseline=1.484   mm(3)) and -0.079   mm(3) in the outer ETDRS subfields (mean baseline=5.206   mm(3)). CONCLUSIONS: SD-OCT measurements allow monitoring the decline in retinal volume in @entity24816 ; however, they require significant manual correction of software errors.
