[Incidence and presentation of the central neurological manifestations of XXXX : a monocentric study of 14 cases].

@entity1 @entity1333 @entity786 @entity49 @entity425 @entity693 @entity1316 @entity2026 @entity134 @entity74 @entity2883
PURPOSE: Central nervous system manifestations are rare clinical features of @entity2883 , and occur in 4-8% of the @entity1 , but few studies were dedicated to them. METHODS: This retrospective study (1988-2001) include 14 consecutive @entity1 suffering from @entity2883 . Involvement of central nervous system was defined as follows: suggestive neurological signs, compatible cerebral imaging, efficacy of the specific treatment of the @entity2883 . RESULTS: Four @entity1 had a central nervous system manifestation (29%), including three @entity1 (average age 51 years). The signs were inaugural in a case. The manifestations were the following: sensibility disturbance (three cases), @entity425 (two cases), @entity2026 (one case), and @entity1316 (two cases). Cranial nerves were constantly involved. Cerebral magnetic resonance imaging findings were: @entity693 and @entity49 (one case), @entity1333 (two cases). Under @entity134 therapy associated with @entity786 , in spite of a recurrence at 27 months in one @entity1 , all @entity1 had a complete remission. There was no death, with a median follow-up of 66 months. Except the ocular signs, that were more common (three cases), these @entity1 had the usual characteristics of the @entity2883 : rhinosinusitis (four cases), pulmonary (three cases), renal (three cases), and peripheral nervous system involvement (three cases). CONCLUSIONS: Our study, based on precise criteria, indicates that the frequency of the central neurologic manifestations of @entity2883 is probably under estimated. Cranial nerves involvement is highly evocative. The long-term prognosis seems good, in spite of the associated @entity74 .
