@entity1735 -responsive gene expression in the adipose tissue of XXXX .

@entity844 @entity28 @entity209 @entity1735 @entity3190 @entity1017 @entity413 @entity412 @entity35 @entity2195 @entity3363
Although @entity28 is often associated with high-fat diets, it can develop from a variety of meal patterns. Excessive intake of simple @entity3363 is one consistent eating behavior leading to @entity28 . However, the impact of overconsumption of diets with high @entity1735 to fat ratios (C/F) on body composition and global adipose tissue gene expression remains unclear. We used total enteral nutrition to evaluate the effects of caloric intake and C/F on body @entity1017 and development of @entity28 . Female @entity35 were fed diets with either low C/F or @entity2195 ( @entity2195 ) (reflecting a 19.5-fold increase in C/F) at two levels of caloric intake: 187 or 220 kcal/kg(3/4) x d (15% excess) for 4 wk. At the end of the study period, @entity35 fed @entity2195 diets had about 20% higher body weight at either caloric intake compared with @entity35 fed low C/F diets (P < 0.05). Body composition (assessed by nuclear magnetic resonance, computerized tomography, and adipose tissue weights) revealed higher percent fat mass (P < 0.05) in @entity2195 @entity35 . @entity28 was associated with increased serum resistin, leptin, fasting @entity3190 , and insulin resistance after an oral @entity413 challenge (P < 0.05). Microarray analyses of adipose tissues revealed @entity2195 diets led to changes in 270 and 464 transcripts at 187 and 220 kcal/kg(3/4) x d intakes. Genes regulating @entity413 transport, glycolysis, @entity844 and @entity412 biosynthesis, desaturation and elongation, adipogenesis, and adipokines were affected by @entity2195 diets. These results suggest that C/F and interactions with excessive caloric intake per se may regulate body composition and play important roles in the development of @entity28 and @entity209 .
