Prognostic impact of pattern-based grading system by the new IASLC/ATS/ERS classification in Asian XXXX with stage I lung adenocarcinoma.

@entity1 @entity5 @entity420 @entity3 @entity2220 @entity1349
OBJECTIVES: We examined the prognostic effect of the grading system based on the new IASLC/ATS/ERS classification in an Asian cohort of @entity1 with early-stage @entity2220 . MATERIALS AND METHODS: @entity1 with a @entity2220 less than 3cm in diameter that had undergone complete anatomic resection, diagnosed with pT1a-2aN0M0 consecutively from 2004 to 2013, were enrolled. All specimens were reviewed according to the new IASLC/ATS/ERS classification. The growth patterns were divided into three major categories: grade 1 for lepidic growth, grade 2 for acinar and papillary patterns, and grade 3 for solid and micropapillary patterns. Each @entity5 was then graded according to the modified grading system, the final score being the sum of the two most predominant grades. The correlations of clinical and pathological factors with disease-free survival (DFS) and @entity1349 ( @entity1349 ) were evaluated. RESULTS: In total, 201 @entity420 were eligible for score grading. Only 37 (18.4%) @entity1 had a pure pathological growth pattern. Higher stage, greater @entity5 diameter, positive @entity3 , and a higher score were associated with shorter DFS. In contrast, stage no longer had a significant impact on @entity1349 in a multivariable analysis. @entity5 with a score of 3 or 4 were associated with better survival than those with a score of 5 (5-year DFS rate: 64.68 vs. 44.18%, HR=2.19, 95% CI: 1.24-3.87; 5-year @entity1349 rate: 85.61 vs. 68.59%, HR=3.03, 95% CI: 1.25-7.32). CONCLUSION: The architectural scores may help to stratify survival differences among certain predominant growth subtypes of @entity420 .
