Investigation of the potential carcinogenicity of a range of @entity3407 containing materials on XXXX lung.

@entity15923 @entity73119 @entity73120 @entity5 @entity957 @entity2 @entity3407 @entity153 @entity35 @entity5954 @entity46184 @entity2220 @entity29728 @entity165
Twenty one @entity3407 containing materials were examined for carcinogenic activity in a two year study using an intrabronchial pellet implantation system whereby pellets loaded with test material were surgically implanted into the lower left bronchus of @entity35 . The principal aim of the study was to extend our knowledge of the carcinogenic potential of @entity3407 compounds and, in particular, @entity29728 ( @entity15923 ). A statistically significant incidence of treatment related @entity5 was found with some sparingly soluble chromate materials. All @entity5 were large keratinizing @entity957 of the left lung, except for a @entity2220 and two @entity2 . No @entity153 (0/100) were seen in the negative control group (blank pellet loaded with @entity165 ), whereas @entity153 (22/48 and 25/100) occurred in the two positive control groups which received pellets loaded with @entity5954 and @entity46184 respectively. Among the 20 test materials, only three groups gave statistically significant numbers of @entity153 . Two of these were groups receiving different samples of @entity73119 which gave 43/99 and 62/99 @entity5 . The third group, @entity73120 (low solubility), gave 5/100 @entity153 . A further @entity73120 group (Norge composition) produced 3/100 @entity153 which was not statistically significant. @entity5 were observed in other test groups.
