Expression of MAGE genes in XXXX .

@entity1 @entity5 @entity71987 @entity10711 @entity2969 @entity71988 @entity4797
OBJECTIVES: Some of the MAGE gene family that @entity5 -rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various @entity5 . However, these genes are silent in normal tissues, except in the testis and placenta. It is therefore important to understand how MAGE gene expression changes with malignant transformation of the testis. We investigated the expression of @entity71987 genes at the mRNA level in @entity2969 . METHODS: Reverse transcriptase-polymerase chain reaction for MAGE genes was performed using 32 testicular germ cell @entity5 specimens. RESULTS: @entity71987 mRNA was detected in 16 (72%), 15 (68%), 18 (82%), and 17 (77%) of 22 @entity1 with pure @entity4797 or mixed type with @entity10711 elements. @entity71987 mRNA was found in 2 (20%), 5 (50%), 4 (40%), and 4 (40%) of 10 @entity1 with @entity10711 ( @entity10711 ). The expression rate of @entity71988 mRNA was significantly higher in @entity1 with @entity10711 elements than that in those with @entity10711 . MAGE expression did not correlate with disease progression. CONCLUSIONS: MAGE genes are more preserved in @entity4797 than in @entity10711 . This suggests that @entity4797 has traits more similar to normal testis than does @entity10711 .
