Knee @entity571 radiographic progression and associations with XXXX and function prior to knee arthroplasty: a multicenter comparative cohort study.

@entity1 @entity3331 @entity571 @entity158
OBJECTIVES: We determined the radiographic osteoarthritic worsening rate prior to knee arthroplasty (TKA) and whether this worsening was associated with worsening @entity158 and function as compared to a non-surgical matched sample. METHODS: We used the @entity571 Initiative 5-year datasets. Extent of knee @entity571 2 years prior to total knee arthroplasty (TKA) was matched to knees of @entity1 who did not undergo TKA. Western Ontario and McMaster Universities Arthritis Index (WOMAC) Function and @entity3331 and @entity571 Outcome Score (KOOS) @entity158 scales were used to quantify functional deficit and functionally relevant @entity158 respectively. A total of 167 @entity1 with isolated TKA and 300 @entity1 with matched symptomatic knee @entity571 but no TKA were studied. RESULTS: During the 2 years prior to TKA, worsening by at least one Kellgren and Lawrence (KL) grade occurred in 27.4% (95% CI  =  20.6-34.2) of the surgical knees compared to 6.6% (95% CI  =  3.8-9.4) of matched non-surgical knees. @entity571 radiographic progression was strongly associated with WOMAC Function and KOOS @entity158 worsening (P  <  0.001) in the 2 years prior to TKA. KL worsening was strongly associated with future arthroplasty (Odds ratio  =  5.0, 95% CI  =  2.6-9.8) after adjustment for potential confounders. CONCLUSIONS: @entity1 undergoing TKA 2 years later had substantial worsening @entity158 and function over the 2-year pre-operative period as compared to a non-surgical sample matched based on KL grades. Almost 30% of @entity1 who elect to undergo TKA undergo rapid disease progression and symptom worsening during the 2 years prior to TKA.
