Perinatal @entity1763 May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn XXXX .

@entity1707 @entity519 @entity179 @entity3612 @entity880 @entity1763 @entity14186
OBJECTIVE: Total tau (T-tau), phosphorylated tau (p-Tau) and Beta-Amyloid 1-42 (AB42) in Cerebrospinal Fluid (CSF) are useful biomarkers in @entity179 . The aim of the study was to investigate the role of these and other CSF biomarkers (T-tau, p-Tau, AB42, @entity14186 and NSE), during @entity519 -reoxygenation in a newborn @entity1707 model. DESIGN: Thirty newborn @entity1707 were included in a study of moderate or severe @entity519 . The moderate @entity519 group (n = 12) was exposed to global @entity519 (8% O2) until Base excess (BE) reached -15 mmol/l. The @entity1707 in the group exposed to severe @entity519 (n = 12) received 8% @entity3612 until BE reached -20 mmol/l or mean Blood Pressure fell below 20 mm Hg, The control group (n = 6) was kept at room air. For all treatments, the CSF was collected at 9.5 hours after the intervention. RESULTS: The level of AB42 in CSF was significantly lower in the @entity1707 exposed to severe @entity519 compared with the control group, 922(SD +/-445)pg/ml versus. 1290(SD +/-143) pg/ml (p<0.05), respectively. Further, a non-significant reduction of AB42 was observed in the group exposed to moderate @entity519 T-tau and p-Tau revealed no significant differences between the intervention groups and the control group, however a significantly higher level of @entity14186 was seen in the CSF of @entity1707 receiving @entity519 in comparison to the level in the control group. Further on, there was a moderate negative correlation between the levels of AB42 and @entity14186 in CSF, as well as a moderate negative correlation between @entity880 in blood at end of @entity519 and AB42 in CSF. INTERPRETATION: This is the first study to our knowledge that demonstrated a significant drop in AB42 in CSF after @entity519 . Whether or not this has an etiological basis for @entity179 needs to be studied with additional experiments and epidemiological studies. AB42 and @entity14186 are significantly changed in neonatal @entity1707 subjected to @entity519 compared to controls and thus may be valuable biomarkers of perinatal @entity1763 .
