Hepatocyte-mediated XXXX and host defense mechanisms in the @entity285 -injured liver.

@entity32 @entity82 @entity5881 @entity1560 @entity137 @entity34049 @entity285 @entity99 @entity1068
The consumption of @entity285 is associated with many health issues including @entity5881 ( @entity5881 ). The natural history of @entity5881 involves the development of @entity1560 , @entity32 ( @entity1560 ), @entity82 and @entity82 . During the stage of @entity1560 , the combination of @entity32 and cellular damage can progress to a severe condition termed @entity99 ( @entity99 ). Unfortunately, the pathogenesis of @entity99 remains uncharacterized. Some modulations have been identified in host defense and liver immunity mechanisms during @entity99 that highlight the role of intrahepatic lymphocyte accumulation and associated inflammatory cytokine responses. Also, it is hypothesized that @entity285 -induced @entity99 cells may significantly contribute to the aberrant lymphocytic distribution that is seen in @entity99 . In particular, the regulation of lymphocytes by hepatocytes may be disrupted in the alcoholic liver resulting in altered immunologic homeostasis and perpetuation of disease. In recent studies, it was demonstrated that the direct killing of activated T lymphocytes by hepatocytes is facilitated by the @entity34049 ( @entity34049 ). The @entity34049 is a well-characterized glycoprotein receptor that is exclusively expressed by hepatocytes. This hepatic receptor is known for its role in the clearance of desialylated glycoproteins or cells, yet neither its physiological function nor its role in disease states has been determined. Interestingly, @entity285 markedly impairs @entity34049 function; however, the effect @entity285 has on @entity34049 -mediated @entity137 of lymphocytes remains to be elucidated. This review discusses the contribution of hepatocytes in immunological regulation and, importantly, how pathological effects of @entity1068 disrupt hepatocellular-mediated defense mechanisms.
