Spontaneous @entity1423 and coagulation parameters as risk factors for XXXX in @entity6 . Results of the PARD-study.

@entity1 @entity4051 @entity64 @entity455 @entity6 @entity1423 @entity1674 @entity797 @entity13717 @entity4461 @entity432 @entity583 @entity65 @entity165
PARD is a prospective study sponsored by the German Research Council with the aim to establish whether spontaneously enhanced @entity1423 or changes of other @entity4461 are risk factors for new @entity432 in @entity6 @entity1 . 363 @entity6 @entity1 (aged 45-65, 232 @entity1 , 131 @entity1 ) were observed for 5 years. Of the 232 @entity1 , 53 were on diet, 104 on oral antidiabetic drugs and 75 on insulin. Of 131 @entity1 16 were on diet, 46 on oral antidiabetic drugs and 69 on insulin. At entry clinical examination and laboratory tests were performed, covering the known risk factors for @entity65 . Hemostatic tests and clinical examination were performed at 3 months' intervals. The life status was followed for all @entity1 . Endpoints were carefully defined. Until December 31, 1984, 42 @entity1 died, 23 from @entity65 and 19 from other causes. 13 @entity1 suffered a @entity583 , 10 a @entity64 and 53 peripheral @entity432 . The occurrence of new @entity432 was significantly higher in those @entity1 with enhanced spontaneous @entity1423 measured by PAT III angle alpha above 40 degrees at entry as compared to those with lower values. This was not the case for @entity1 . Other @entity4461 , which had also some relation to @entity65 , in @entity1 were fibrinogen and F. @entity797 R:Ag. Established risk factors for which a significant relation to @entity65 was observed in this study, were smoking, duration of @entity6 , diastolic blood pressure, @entity165 , @entity1674 and also @entity4051 . The results of the PARD-study have verified the hypothesis that @entity13717 is a major risk factor for future @entity432 in @entity6 @entity1 . They also lead to the hypothesis that high levels of F. @entity797 R:Ag and fibrinogen are further indicators of progressive @entity455 and may be useful as predictors of new @entity432 in combination with such established risk factors as smoking, duration of @entity6 , diastolic blood pressure, @entity165 , and @entity1674 .
