An examination of survival by sex and race in the HeartWare Ventricular Assist Device for the Treatment of Advanced XXXX (ADVANCE) Bridge to Transplant (BTT) and continued access protocol trials.

@entity1 @entity296 @entity712 @entity101 @entity548 @entity177 @entity1011 @entity943
BACKGROUND: The Ventricular Assist Device for the Treatment of Advanced @entity712 (ADVANCE) Bridge to Transplant (BTT) trial was a multicenter, prospective trial of the HeartWare Ventricular Assist Device (HVAD). The performance of the HVAD in various demographic sub-groups was evaluated. METHODS: Baseline characteristics, adverse events, and survival were compared for @entity1 vs @entity1 and whites vs non-whites in the combined ADVANCE BTT and continued access protocol trial. Of 332 @entity1 enrolled in these trials, 236 were @entity1 and 96 @entity1 , with 228 whites and 104 non-whites. RESULTS: At baseline, @entity1 had a smaller body surface area (1.8    0.2 vs 2.1    0.3 m(2), p < 0.0001), less @entity101 (50.0% vs 61.9%, p = 0.05), and less @entity296 (15.6% vs 45.3%, p < 0.0001). Differences in Kaplan-Meier survival were not significant at 180 days ( @entity1 , 91.8%; @entity1 , 91.7%) and 1 year ( @entity1 , 85.3%; @entity1 , 85.1%) despite adjustment for baseline differences. @entity1 had a lower incidence of early right @entity712 and @entity177 , and a shorter length of stay. In the analysis by race, non-whites were younger than whites and had less @entity712 , more @entity101 , and lower @entity1011 levels at baseline. Non-whites had lower rates of @entity943 , @entity548 requiring rehospitalization, and device malfunctions than whites. Survival was high in non-whites and whites, at 94.1% vs 90.4% at 180 days and 89.2% vs 82.8% at 1 year, respectively, despite adjustment for baseline differences. CONCLUSIONS: Although @entity712 etiology differed between @entity1 and @entity1 and between whites and non-whites, sex and race were not factors that affected survival in @entity1 receiving the HVAD as BTT, which was high in all sub-groups.
