XXXX Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to @entity72 .

@entity1 @entity410 @entity19 @entity245 @entity471 @entity72 @entity161 @entity302 @entity716 @entity717 @entity4651
The chromosome 15q13.3 microdeletion is a pathogenic copy number variation @entity302 , @entity717 , @entity161 , and @entity72 ( @entity72 ). We generated @entity19 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity1 @entity1 . Here, we report that @entity19 with a heterozygous deletion on a C57BL/6 background (D/+ @entity19 ) demonstrated phenotypes including enlarged/heavier brains ( @entity4651 ) with enlarged lateral ventricles, decreased social interactions, increased repetitive grooming behavior, reduced ultrasonic vocalizations, decreased auditory-evoked gamma band EEG, and reduced event-related potentials. D/+ @entity19 had normal body weight, activity levels, sensory gating, and cognitive abilities and no signs of @entity302 / @entity410 . Our results demonstrate that D/+ @entity19 represent @entity72 -related phenotypes associated with 15q13.3 microdeletion syndrome. Further investigations using this chromosome-engineered @entity19 model may uncover the common mechanism(s) underlying @entity72 and other @entity245 representing the 15q13.3 microdeletion syndrome, @entity302 , @entity717 , and @entity161 . SIGNIFICANCE STATEMENT: Recently discovered pathologic copy number variations (CNVs) from @entity1 with @entity245 show very strong penetrance and thus are excellent candidates for @entity19 models of disease that can mirror the @entity1 genetic conditions with high fidelity. A 15q13.3 microdeletion in @entity1 results in a range of @entity245 , @entity302 , @entity717 , @entity161 , and @entity72 ( @entity72 ). The disorders conferred by a 15q13.3 microdeletion also have overlapping genetic architectures and comorbidity in other @entity1 populations such as those with @entity302 and @entity161 / @entity716 , as well as @entity161 and @entity72 . We generated @entity19 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity1 @entity1 , which allowed us to investigate the potential causes of @entity245 associated with the @entity471 .
