Surgical management of pituitary XXXX .

@entity1 @entity227 @entity263 @entity66 @entity41 @entity0 @entity5 @entity1887 @entity703 @entity3 @entity892 @entity259 @entity320 @entity2010
BACKGROUND: Pituitary @entity3 are rare and commonly described in case reports or small case series. Due to its rarity this entity is not subject to standardized treatment guidelines, there is debate about typical initial symptoms that may lead to finding the correct diagnosis and information about the clinical course is also sparse. METHODS: We have conducted a retrospective analysis of @entity1 with pituitary @entity3 who were surgically treated via a transsphenoidal procedure at our institution between 2006 and 2014. Underlying @entity66 , clinical and surgical course as well as adjuvant radiotherapy and follow-up data are presented. RESULTS: 14 @entity1 met the inclusion criteria (8 female, 6 male). Mean age was 61.5  years. Most @entity1 became symptomatic with visual symptoms-both @entity227 and/or @entity892 (n  =  13)-and @entity1887 (n  =  8). Surprisingly @entity2010 was only seen in three @entity1 . All @entity1 underwent transsphenoidal surgery initially, four @entity1 had to undergo surgery for @entity41 or recurrence, two of them via a transcranial route. @entity0 was the most common entity (n  =  6), followed by @entity263 (n  =  3), nsclc (n  =  2) and @entity320 , @entity259 and @entity703 in one case each. Postoperative MRI showed gross total resection in four cases and @entity66 in eight cases (subtotal resection, partial resection and biopsy), two @entity1 files were incomplete regarding MRI-results. All @entity1 underwent adjuvant radiotherapy. Survival after the initial diagnosis of @entity5 was 36 and 16  months after diagnosis of pituitary @entity3 . CONCLUSION: Our results indicate that transsphenoidal surgery is a safe method to resect pituitary @entity3 and that the extend of resection does not have an influence on survival time. Our results also indicate that @entity2010 may not be the most common initial symptom of pituitary @entity3 and lack thereof should not lead to making a wrong diagnosis and delaying appropriate therapy.
