Proapoptosis and antiapoptosis-related molecules during postnatal pancreas development in control and nonobese @entity6 XXXX : relationship with innervation.

@entity6 @entity19 @entity1723 @entity21772 @entity9699 @entity1379 @entity792
The @entity19 pancreas, an immature organ at birth, reaches its adult size and morphology after weaning (3 weeks of age). Around this time, apoptotic phenomena and various types of macrophages are normally present. During development, @entity9699 ( @entity9699 ) interactions are known to play a role in apoptotic events involved in tissue remodeling and elimination of damaged cells, and macrophages are routinely observed near apoptotic cells. Apoptosis and Fas- @entity9699 interactions are also thought to be involved in the pathogenesis of @entity792 , particularly @entity1723 ( @entity1723 ). Therefore, we used early postnatal @entity19 pancreata from three control strains (C57BL/6, DBA/2, BALB/c) and from two strains with the nonobese @entity6 (NOD)-related genetic background (the spontaneous @entity1723 NOD model and the lymphocyte-deficient NODscid strain) to study apoptotic phenomena together with the molecular and immunohistochemical expression of proapoptosis (Fas, @entity9699 ) and antiapoptosis ( @entity1379 ) proteins. First, although no major difference in the numbers of total pancreatic apoptotic cells was noted among strains, significantly more @entity9699 (+) expression was detected immunohistochemically in @entity19 with the NOD genetic background than in control pancreata from birth to 1 month of age. Second, @entity9699 (+), Fas(+), and @entity1379 (+) structures seemed to be associated with innervation, regardless of the strain and age. Third, in control and NOD strains, nerves (identified by immunohistochemical labeling of @entity21772 or neurofilament 200), were often observed in periductular and peri-insular areas. Finally, some @entity21772 -positive nerves expressed the interferon-inducible protein-10 chemokine, and various types of macrophages were found to be in close proximity. These data highlight an overlooked, innervation-related aspect of normal @entity19 postnatal pancreas development with possible implications in @entity1723 pathogenesis.
