Ultraviolet radiation-induced cytokines promote mast cell accumulation and matrix metalloproteinase production: potential role in XXXX .

@entity1 @entity32 @entity5737 @entity3334 @entity3830 @entity1495 @entity8252
OBJECTIVE: To examine the role of mast cells (MCs), cytokines, and matrix metalloproteinases (MMPs) following ultraviolet B (UVB) radiation in @entity3830 ( @entity3830 ). METHODS: Immunohistochemistry was used to determine the presence of MCs and the expression of @entity3334 , @entity1495 , @entity8252 , and @entity5737 / @entity5737 in skin from @entity1 with @entity3830 . @entity1 keratinocytes were exposed to varying doses of UVB and supernatants were collected and assessed for @entity8252 , @entity5737 , @entity3334 , and @entity1495 by protein assays. MC migration was determined against supernatants from UVB-treated keratinocytes. RESULTS: MCs in the skin of @entity1 with @entity3830 were significantly increased. @entity3334 and @entity1495 expression was abundant in these lesions. Intense reactivity for @entity8252 and @entity5737 was found in skin, particularly in epidermal keratinocytes, from @entity1 with @entity3830 . UVB irradiation induced @entity8252 , @entity5737 , @entity3334 , and @entity1495 production from keratinocytes in a dose- and time-dependent manner. Supernatants obtained from UVB-treated keratinocytes induced MC migration, which was attenuated by anti- @entity8252 and anti- @entity5737 neutralizing antibodies. @entity8252 induced MC-derived MMP production. CONCLUSIONS: Our results indicate that MCs and MMPs may play a role in the @entity32 in @entity3830 . MC recruitment as well as MMP production may be perpetuated by UV irradiation through locally released mediators.
