Immunological heterogeneity in @entity1 XXXX : immunogenic alloantigen expression in autologous host.

@entity1 @entity5 @entity320 @entity4107
A @entity1 presented with a primary @entity320 , Level IV, 2.5 mm thick; 30 excised lymph nodes were all negative for @entity5 . Four local recurrences followed in the ensuing 17 months. @entity5 cells cultured at this time were epithelioid. Autoimmunization was followed by a disease-free interval of 15 months. Postimmunization, the @entity1 's lymphocytes destroyed his @entity320 cells in culture and were stimulated in mixed cell culture by his irradiated @entity5 cells. Cells grown from the relapsing @entity5 were spindle/dendritic with bizarre morphology and were not attacked by his lymphocytes in culture. Using a C' fixation technique, DR antigen profiles of the @entity1 's B-cells and both @entity5 cell types showed that the immunizing @entity5 was positive for DR antigens 3, 5, and 8, none of which were present on his B-cells which had @entity4107 . Both B-cells and immunizing @entity5 cells were positive for DQ antigens. The relapsing @entity5 cells were positive for DR2 and negative for all other D region antigens tested. The evidence suggests that given a @entity320 of heterogeneous cell population, autoimmunization against the predominant immunogenic cell inhibits @entity5 growth but allows the ascendance of a nonimmunogenic @entity5 cell type.
