Sentinel node biopsy in XXXX : preliminary results.

@entity1 @entity5 @entity356
BACKGROUND: Extent of lymphadenectomy in @entity356 is one of the still unresolved and ongoing questions. Whether extensive procedures lead to better survival remains controversial. The detection of sentinel node could become a helpful method to define the desirable extent of lymph node dissection for each particular @entity1 . MATERIAL AND METHODS: Prospective, single-centre, clinical trial. Sentinel node is identified using vital blue dye. After performance of D2 lymphadenectomy, the pathologist minutely investigates all lymphatic nodes by histological and immunohistochemistry techniques. RESULTS: During a period of 36 months, an attempt to localise the sentinel node for biopsy was made in 22 @entity1 . The successful rate of sentinel node detection with a good relation between metastatic involvement of the sentinel node and other nodes was 56% (13 out of 22 @entity1 ). All these @entity1 suffered from small @entity5 and early stage of the disease. In large @entity5 and advanced stages, blue dye stained the tissue around the @entity5 diffusely rendering the identification of true sentinel node impossible. Fresh frozen section of the sentinel node resulted in two @entity1 in a false negative outcome because of micrometastatic involvement. CONCLUSIONS: Sentinel node biopsy in @entity356 using vital staining is a feasible method. Reliable results were seen in early stage of the disease. Fresh frozen section of sentinel node has probably a low sensitivity for detection of micrometastases.
