Prospective Study of Dental Intervention for XXXX .

@entity1 @entity295 @entity149 @entity281 @entity1583 @entity166
UNASSIGNED: Various chemotherapeutic agents used in @entity1 with @entity1583 cause serious side effects, including myelosuppression and immunosuppression. Immunosuppression makes @entity1 more susceptible to @entity281 , resulting in an increased risk of @entity166 , including the development of severe @entity295 that may be life-threatening. It is necessary for dental staff to be familiar with an appropriate protocol in such cases and to share information about the chemotherapy with a hematologist. To verify the effectiveness of our dental intervention protocol, we conducted a prospective study on the incidence of complications for each myelosuppressive grade of chemotherapy in @entity1 with @entity1583 . We compared the incidence of complications between treatment P ( @entity1 who finished all the dental treatments according to the protocol) and treatment Q ( @entity1 who did not) per grade (A, B, C, D) and incidence of systemic or oral findings. We also compared the incidence of oral complication related to the residual teeth between first chemo ( @entity1 who were undergoing chemotherapy for the first time) and prior chemo (not the first time). There were significant differences in inflammatory complications between treatment P and treatment Q. We found that both systemic and oral inflammatory complications increased with higher-grade myelosuppressive chemotherapy. Additionally, there was a significant difference between the incidence of oral complications related to the residual teeth between first chemo and prior chemo. Complete implementation of the dental intervention protocol was associated with fewer oral and systemic @entity166 and inflammatory complications in @entity1 with @entity1583 undergoing chemotherapy. The incidence of @entity149 also increased with grade of chemotherapy. These results support the validity of our dental intervention protocol. We should pay close attention to the oral state of de novo @entity1583 @entity1 .
