Treatment of XXXX with topical interferon Alfa-2b.

@entity1 @entity5 @entity3169
PURPOSE: Two @entity1 with biopsy-proven @entity3169 exhibited complete resolution after treatment with topical Interferon Alfa-2b (IFNalpha2b). DESIGN: Interventional case reports. METHODS: Two @entity1 with monocular biopsy-confirmed @entity3169 were treated with IFNalpha2b, 1 million units/cc, one drop four times daily until clinical resolution was achieved. RESULTS: ( @entity1 1) The lesion's size was significantly reduced at 1 month. Complete resolution was noted at the 3-month visit. No recurrences were seen 40 months post-treatment. ( @entity1 2) The lesion completely resolved after 6 weeks of treatment. No recurrence has occurred 18 months post-treatment. No systemic or local side effect of treatment was noted. CONCLUSIONS: Two sizable @entity3169 resolved using topical IFNalpha2b alone. Interferon is usually not considered effective for large solid @entity5 without surgical debulking. We realize that this is a limited case series, but these cases may serve as a basis for further investigation.
