Risk Analysis of XXXX : Prospective 10-Year Cohort Study.

@entity1 @entity548 @entity438 @entity510 @entity439 @entity397 @entity1756
BACKGROUND AND PURPOSE: The natural history of unruptured @entity438 remains unclear, and management strategy is not well defined. METHODS: From January 2003 to December 2012, we enrolled @entity1 with @entity439 in our institution. In total, 2252 @entity1 with 2897 @entity439 were eligible for analysis, and 1960 eligible @entity439 were conservatively managed. Precise 3-dimensional evaluation was conducted using computed tomography angiography, digital subtraction angiography, or magnetic resonance angiography. We then assessed the risk of @entity1756 , mortality, and morbidity associated with @entity439 characteristics, demographics, and known health/lifestyle risk factors. RESULTS: The mean follow-up duration was 7388 @entity439 -years. During observation, 56 @entity1756 , resulting in an overall @entity397 rate per year of 0.76% (95% confidence interval, 0.58-0.98). The mean initial visit to @entity397 interval was 547 days. @entity439 size, location, daughter sac, and history of @entity510 were significant independent predictors for @entity1756 . @entity439 that were >= 5 mm were associated with a significantly increased risk of @entity397 when compared with 2-to 4-mm @entity439 (unadjusted hazard ratio, 12.24; 95% confidence interval, 7.15-20.93). Of 56 @entity1 who experienced @entity548 , 29 (52 %) died or were rendered severely disabled. Of the @entity1 who had large or @entity439 , none recovered without deficits, and the mortality rate after @entity397 was 69%. For @entity439 sized <5 mm, the mortality rate was 18%. CONCLUSIONS: Larger @entity439 are at greater risk for @entity397 and poor outcome. Ethnic factors may play a role in the risk of @entity397 .
