Associative control of tolerance to the sedative and hypothermic effects of XXXX .

@entity8685 @entity13667 @entity35 @entity221 @entity25 @entity2332
Pavlovian control of tolerance to the sedative and hypothermic effects of @entity8685 ( @entity13667 ) was demonstrated in two experiments. In Experiment I, drug-experienced @entity35 were repeatedly treated with @entity13667 (30 mg/kg) in one environment (CS+); on alternate days, they were given saline injections in a different environment (CS-). @entity25 and inactivity were used as measures of sedation. A comparable conditioning procedure was used in Experiment II, but tolerance to the hypothermic effect of @entity13667 was the dependent measure. During tolerance testing, @entity35 from both Experiments I and II were given @entity13667 in one of three environments, CS+, CS-, or a novel environment (CSnov). In Experiment I, @entity35 were equally tolerant in all three test environments when duration of sleep was assessed. However, when inactivity was used as the measure of tolerance, @entity35 showed tolerance in CS+ and CS-, and significantly less tolerance in CSnov. Drug-naive controls showed similar nontolerant responses to @entity13667 in all environments, thus ruling out the possibility that the effect of sedation was mediated nonassociatively. In Experiment II, drug-experienced @entity35 showed tolerance to @entity13667 -induced @entity2332 in CS+ and CS- but less tolerance in CSnov. A compensatory @entity221 was observed when these @entity35 were given saline in CS+. There was some evidence for a generalization gradient in the conditional control of tolerance in both experiments.
