Short-term cold acclimation recruits brown adipose tissue in obese XXXX .

@entity1 @entity419 @entity6 @entity28 @entity2368 @entity4854 @entity413
UNASSIGNED: Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat @entity28 and associated metabolic complications. Short-term cold acclimation has been shown to not only enhance BAT presence and activity in lean @entity1 , but also improve skeletal muscle metabolic profile to benefit @entity413 uptake in type 2 @entity6 @entity1 . Here, we examined whether short-term cold acclimation also induced such adaptations in ten metabolically healthy obese male subjects. A 10-day cold acclimation period resulted in increased cold-induced @entity413 uptake in BAT, as assessed by @entity419 -PET/CT scanning. BAT activity was negatively related to age, with a similar trend for body fat%. In addition, cold-induced @entity413 uptake in BAT was positively related to @entity413 uptake in visceral WAT, although @entity413 uptake in visceral and subcutaneous WAT depots was unchanged upon cold acclimation. Cold-induced skeletal muscle @entity413 uptake tended to increase upon cold acclimation, which was paralleled by increased basal @entity2368 localization in the sarcolemma, as assessed in muscle biopsies. Proximal skin temperature was increased and subjective responses to cold were slightly improved at the end of the acclimation period. These metabolic adaptations to prolonged mild cold exposure may lead to improved @entity413 metabolism or prevent development of @entity28 -associated insulin resistance and @entity4854 . TRIAL REGISTRATION NUMBER: NTR4319.
