Secondary Infections in @entity1398 in XXXX : More Than Another Febrile Neutropenic Episode.

@entity1 @entity1398 @entity364 @entity325 @entity1583 @entity72044 @entity2259
INTRODUCTION: @entity72044 ( @entity72044 ) are among major causes of mortality in @entity1 with @entity1583 . @entity325 develop either during the empirical antibiotic therapy or one week after cessation of therapy for a FNE. The aim of the study was to investigate the risk factors associated with secondary infections in febrile neutropenic @entity1 . METHODS: We retrospectively analyzed 750 @entity72044 in 473 @entity1 between January 2000 and December 2006. RESULTS: @entity325 were diagnosed in 152 (20%) of 750 @entity72044 . The median time to develop secondary infection was 10 days (range 2-34 days). The duration of @entity1398 over 10 days significantly increased the risk of secondary infections (p<0.001). The proportion of @entity1 with microbiologically documented infections was found to be higher in primary infections (271/750, 36%) compared to secondary infections (43/152, 28%) (p=0.038). Age, sex, underlying disease, antibacterial, antifungal or antiviral prophylaxis, blood transfusion or bone marrow transplantation, central venous catheter or severity of @entity1398 did not differ significantly between primary and secondary infections (p>0.05) While fever of unknown origin (FUO) (p=0.005) and catheter-related @entity2259 (p<0.001) were less frequently observed in secondary infections, the frequency of microbiologically (p=0.003) and clinically (p<0.001) documented infections, @entity364 (p<0.001), infections related with gram positive bacteria (p=0.04) and fungi (p<0.001) and 30-day mortality rate (p<0.001) were significantly higher in secondary infections (p<0.001). DISCUSSION AND CONCLUSION: @entity325 should be regarded as life-threatening complications of @entity1398 . @entity325 represent a more severe and mortal complication and cannot be regarded just as another febrile neutropenic episode.
