XXXX : A systematic review.

@entity1 @entity943 @entity146 @entity944 @entity448 @entity1278 @entity1163 @entity551 @entity299 @entity204 @entity1168 @entity65 @entity616
OBJECTIVE: @entity1278 portends the highest mortality among @entity146 , despite primarily being a disease of adolescents and younger adults. Although some of this mortality risk is attributable to suicide, many @entity204 are likely cardiovascular in etiology. Recent studies suggest that adverse myocardial structural changes occur in this condition, which could underlie the increased mortality. Given limited prevalence of severe @entity448 there is a paucity of clinical and autopsy data to discern an exact cause of @entity204 . METHODS: Given this background we conducted a systematic review of the medical literature to provide a contemporary summary of the pathobiologic sequelae of severe @entity65 . We sought to elucidate the @entity1278 in four cardiovascular domains: structural, repolarization/conduction, hemodynamic, and peripheral vascular. RESULTS: A number of @entity299 associated with @entity1278 have been described in the literature, including pericardial and valvular pathology, changes in left ventricular mass and function, @entity616 , @entity1168 , @entity551 , and dysregulation in peripheral vascular contractility. Despite the prevalent theory that malignant @entity943 are implicated as a cause of @entity944 in this disorder, data to support this causal relationship are lacking. DISCUSSION: It is reasonable to obtain routine electrocardiography and measurements of orthostatic vital signs in @entity1 presenting with @entity1278 . Echocardiography is generally not indicated unless prompted by clinical signs of disease. Admission to an inpatient unit with telemetry monitoring is recommended for @entity1 with severe sinus @entity1168 or junction rhythm, marked prolongation of the corrected QT interval, or @entity1163 .    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015).
