Insulin deficiency rather than XXXX accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 @entity3949 .

@entity1 @entity66 @entity6 @entity3249 @entity3949 @entity1717 @entity2135 @entity18424 @entity35 @entity18423 @entity1602 @entity4854 @entity130 @entity7814
@entity3949 ( @entity3949 ) shows more severe functional and structural changes in type 1 than in type 2 @entity1 and experimental @entity6 . We have previously suggested that these differences may be due to insulin and/or C-peptide deficiencies in type 1 @entity6 . To further explore these differences between type I and type 2 @entity3949 , we examined factors underlying nerve fiber regeneration in the @entity1717 BB/Z- @entity35 and compared these with previous data obtained from the iso- @entity1602 , insulin and C-peptide-deficient type 1 @entity6 BB/Wor- @entity35 . The expression of neurotrophic factors and cytoskeletal proteins were studied in L4 and L5 dorsal root ganglia (DRG) at various time points after sciatic nerve crush. The data were compared to those of nondiabetes-prone BB- @entity35 . @entity2135 ( @entity2135 ) and @entity3249 levels were lower in DRG from type 1 than from those of type 2 and control BB- @entity35 . On the other hand, @entity7814 expression was increased at baseline in type 1 BB/Wor- @entity35 and decreased after @entity130 , whereas its expression increased after @entity130 in both control and type 2 BB/ @entity35 . Following @entity130 , betaII- and betaIII-tubulins were upregulated in type 2 BB/Z and control @entity35 , which did not occur in type 1 BB/Wor- @entity35 . Furthermore, type 2 BB/ @entity35 showed the normal downregulation of low and medium molecular neurofilament ( @entity18423 and @entity18424 , respectively), which did not occur in type 1 BB/Wor- @entity35 . These findings were associated with significantly milder @entity66 and caliber growth of regenerating fibers in type 2 compared to type 1 @entity6 @entity35 . These data suggest that @entity6 may be of greater significance in the regulation of neurotrophic and neurocytoskeletal protein synthesis than @entity4854 in explaining the differences in nerve fiber regeneration between type 2 and type 1 @entity6 .
