Colonic mucosal T lymphocytes in @entity31 : expression of XXXX antigen in relation to MHC class II (HLA-D) antigens.

@entity1 @entity404 @entity7279 @entity31 @entity5893 @entity1196 @entity1960 @entity4587 @entity405
T-cell subsets and their activation state were examined by double-label immunofluorescence of cryostat tissue sections of the colon from 21 @entity1 with @entity31 ( @entity31 ) and 30 histologically normal controls. Expression of MHC class I (HLA-A, B, C) and class II (HLA-D) antigens was studied in parallel. In the normal colonic mucosa, the @entity404 : @entity405 ratio in the epithelial compartment approximated 1:1, and in the lamina propria, 2.55:1. Of the @entity405 + (cytotoxic/suppressor) subset, approximately half did not express the @entity5893 "pan-T" marker in either compartment. Virtually no @entity1196 + cells were observed, implying that the @entity404 + subset consisted of helper, rather than suppressor-inducer cells. Classical markers of T-cell activation (CD25, HLA-D) and proliferation were absent, and strong expression of the @entity4587 "immunostimulation" marker was approximately equal in both @entity404 and @entity405 subsets. The epithelium was uniformly negative for class II antigens, but positive for class I. In @entity31 , there were no significant alterations in @entity404 : @entity405 ratios in either compartment, and there were no changes with respect to phenotype of the subsets. In 11 of 19 @entity1 (mainly with total @entity1960 ), enterocytes were HLA-D+. In this HLA-D+ group, there was an increase in the percentage of @entity404 + cells coexpressing @entity4587 ; this difference was significant (P less than 0.02) in the lamina propria. Increased expression of @entity4587 was also found by the @entity7279 + T cell subset (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
