Effect of enalaprilat on XXXX and des-Arg9- @entity1812 release following reperfusion of the ischaemic @entity35 heart.

@entity1811 @entity17914 @entity1812 @entity35 @entity51836
1. The release of @entity1812 (BK) and its metabolite, @entity51836 (des-Arg9-BK), was studied following reperfusion of a globally ischaemic @entity35 heart. 2. BK-like immunoreactivity increased from 13 +/- 3 (preischaemic value) to 48 +/- 12 fmol min-1 g-1 (P < 0.05, n = 14) 30 s after reperfusion. No difference in BK release was found between control hearts and hearts pretreated with the angiotensin converting enzyme ( @entity1811 or @entity1811 ) inhibitor, @entity17914 (50 ng ml-1). 3. No significant change in des-Arg9-BK-like immunoreactivity during reperfusion was observed in control hearts. In contrast, des-Arg9-BK-like immunoreactivity rose from 44 +/- 15 to 177 +/- 61 fmol min-1 g-1 (P < 0.05, n = 7) 30 s after reperfusion in enalaprilat-treated hearts. 4. In conclusion, BK is released upon reperfusion of the globally ischaemic @entity35 heart. @entity1811 inhibitors, through the inhibition of @entity1811 , increase the formation of the active metabolite, des-Arg9-BK.
