Immunoglobulin G profiles in different forms of XXXX .

@entity1 @entity7278 @entity2521 @entity146
BACKGROUND: Races and Gm(23) allotypes can modify the serum levels of IgG subclasses. The average serum levels of IgG subclasses of African-Americans have been reported to be higher than those of Caucasians in both healthy young adults and @entity1 with @entity146 ; Gm(23)-positive subjects generally had higher IgG2 levels than Gm(23)-negative subjects. OBJECTIVE: We examined serum immunoglobulin G (IgG) concentrations in Taiwanese @entity1 with different forms of @entity2521 . METHODS: The serum levels of four IgG subclasses were determined by enzyme-linked immunosorbent assay and Gm(23) allotypes were verified by radial immunodiffusion tests in 50 @entity1 with @entity7278 , 30 @entity1 with @entity146 , and 74 healthy controls. RESULTS: There were no differences in the concentrations of four IgG subclasses in @entity1 with @entity7278 compared with age-matched controls. However, in subjects younger than 35 years, levels of IgG2 were significantly elevated in @entity1 with @entity146 compared with controls. We also found significant differences in IgG2 levels within the control group when stratified by age (< or = 35 years and > 35 years). Gm(23) allotypes were not correlated with the serum levels of IgG2 in either @entity1 group. CONCLUSION: Microbial challenge might not provoke significant changes in systemic IgG response in @entity1 with @entity7278 . However, in @entity1 with @entity146 , IgG2 levels were increased when compared with age-matched controls. Gm(23) allotypes had no influence on IgG2 levels in well-established generalized @entity7278 or @entity146 .
