Association study between polymorphisms in the @entity10598 , @entity18128 , and @entity22826 genes and XXXX in the Chinese Han population.

@entity1 @entity10598 @entity302 @entity460 @entity22826 @entity18128 @entity734
PURPOSE: As important ion channels of the central nervous system, @entity460 channels not only take part in epileptogenesis but also act as the targets of commonly used @entity734 ( @entity734 ). Thus, this study aimed to provide the first investigation of the association between @entity10598 , @entity18128 , and @entity22826 single nucleotide polymorphisms (SNPs) and AED resistance in the Chinese Han population. METHODS: We performed genotyping of tagging single nucleotide polymorphisms (tagSNPs) of @entity10598 H in 480 Chinese @entity302 @entity1 (288 drug-responsive and 192 drug-resistant @entity1 ). The Illumina GoldenGate BeadArray assay was used to detect the genotypes of all of the @entity1 . A total of 15 SNPs were selected based on the HapMap database. The genotype distributions in drug-responsive and drug-resistant @entity1 were compared, and the haplotype frequencies of each gene were calculated. RESULTS: None of the 15 tagSNPs alleles were found to be associated with @entity302 . However, the frequency of the TAGAA haplotype in @entity10598 was significantly higher in drug-resistant @entity1 than in drug-responsive @entity1 after the correction of multiple comparisons with Bonferroni's method (TAGAA 13.3% vs. 7.1%, OR=2.129 [1.373-3.299], P=0.00059<0.05/10). CONCLUSIONS: This study revealed no association between the 15 tagSNPs of @entity10598 , 1C, and 1H and drug efficacy in the Chinese Han population. The TAGAA haplotype of @entity10598 may be a risk factor for AED resistance.
