Quality of life and adverse events after radiotherapy in XXXX survivors: a cohort study.

@entity5 @entity1 @entity546 @entity158
PURPOSE: To evaluate quality of life (QOL) in @entity5 survivors after radiotherapy (RT), investigate the frequency of adverse events and demonstrate an association between these symptoms and QOL. METHODS: A prospective cohort study of 95 @entity1 aged 21-75 years undergoing RT for @entity5 was carried out. QOL was assessed by the WHOQOL-BREF before, at 4 months, 1 year and 3 years after RT and adverse events were evaluated following RT by the (CTCAE) v 3.0 scale. QOL scores were assessed by the Wilcoxon signed rank test over time. Multiple linear regression analysis was used to identify predictors of QOL. RESULTS: The most frequent adverse events were @entity158 (64.2%) and @entity546 (45.9%). A significant increase in QOL scores was observed in the psychological domain, general health and overall QOL. @entity158 was negatively associated with the physical, psychological and social relationship domains (p < 0.01); @entity546 with the physical and social relationship (p < 0.01); decreased sexual interest with the psychological (p < 0.01). Higher family income was positively associated with the psychological domain and general health (p < 0.01). CONCLUSIONS: Results suggested that QOL improved after RT in @entity1 with @entity5 . Adverse events, such as @entity158 , @entity546 and decreased sexual interest had a negative impact on QOL.
