Chromosome analysis of nine XXXX .

@entity242 @entity5 @entity876 @entity2526 @entity995 @entity421 @entity2008 @entity1048
Although recurrent @entity2008 have been identified in several histologic subtypes of @entity242 , no consistent rearrangement has yet been found in @entity421 . Cytogenetic analyses of nine cases of @entity421 are reported, including seven newly diagnosed @entity5 and two recurrent @entity5 . There were seven high-grade @entity421 , one @entity1048 , and one well-differentiated @entity242 . All @entity5 were studied in short-term primary culture. Modal number ranged from near diploid to near triploid. Seven @entity5 had complex karyotypes with multiple structural abnormalities; two had only normal karyotypes. The @entity995 gene on chromosome 13 and the @entity876 gene on chromosome 17 have been involved in @entity421 . @entity5 had loss of a whole copy of chromosome 13, and three of these also had a loss of a whole copy of chromosome 17. However, these losses were observed in the setting of numerous other chromosome losses. @entity2526 were observed, many involving additions of unidentified material, unbalanced translocations, or deletions. @entity2526 with similar breakpoints involving 6q, 8q, 9q, and 14p were seen in two or three @entity5 each. When the @entity5 in this series were added to the 18 published cases, the pericentromeric regions of chromosomes 1, 3, and 14, and segments 6q15-21, 8q24, 9q34, 12p13, 17p13, and 19q13, were found to be involved in five or more structural rearrangements. Molecular analyses of these chromosome regions may yield genes important in the pathogenesis of @entity421 .
