Impact of antibiotic changes in empirical therapy on antimicrobial resistance in intensive care unit-acquired XXXX .

@entity1 @entity3256 @entity1597 @entity2892 @entity796 @entity868 @entity115 @entity55 @entity6944 @entity794 @entity7120 @entity798 @entity281 @entity580 @entity3400 @entity207 @entity298 @entity206
We conducted a one-year prospective study on intensive care unit (ICU)-acquired @entity281 and antimicrobial resistance patterns in an 18-bed medical-surgical ICU of a tertiary-care university hospital. We divided the study into two six-month periods in order to evaluate the impact of antibiotic changes in empirical therapy on antimicrobial resistance profiles of the principal isolated micro-organisms. In the first period no changes were made to the previously applied empirical antibiotic protocol; at the end of this period we found high rates of @entity3256 resistance (MR) among staphylococci, 93% for @entity794 (69 isolates) and 79% for coagulase-negative staphylococci (CNS) (48 isolates), and of multiple drug resistance for @entity796 (57 isolates), in particular 67% resistance to @entity3400 / @entity7120 (PIP/TZ). We therefore decided to substitute PIP/TZ with imipenem in @entity55 and with @entity6944 plus @entity868 in @entity298 . We also considered the previous use of @entity115 / @entity798 (AM/CL) at admission in critically ill @entity1 inadequate; we therefore advised that no antibiotics should be given unless fever developed and eventually to replace AM/CL with @entity206 / @entity207 ( @entity1597 /SMX). At the end of this intervention period, we observed a significant decrease of @entity794 MR (93 vs. 73%, P = 0.003) and of @entity796 resistance to PIP/TZ (67 vs. 29%, P < 0.001). A reduction in MR was also seen in CNS (79 vs. 64%, P = 0.09). Other resistance patterns also improved among staphylococci; in contrast @entity796 resistance to @entity2892 increased in the second period (24 vs. 41%, P = 0.06). A non-premeditated change of antibiotics in empirical therapy, on the basis of detected resistance patterns, provided promising results in reducing some antimicrobial resistance rates. We believe, however, that antibiotic changes must be tailored to local microbiological situation monitoring, and that a repeated rotation is crucial to limit the emergence of new resistance profiles. Furthermore the adoption of this policy should be accompanied by other infection control practices aimed at reducing antimicrobial resistance and @entity580 rates.
