Interleukin-17 and XXXX synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

@entity650 @entity32 @entity3646 @entity4155 @entity379 @entity1192 @entity2071 @entity8252 @entity687
Keratinocytes are influenced by cytokines released by skin-infiltrating T lymphocytes. @entity4155 is produced by activated CD4+ T cells and can stimulate epithelial cells. We investigated whether @entity4155 could modulate the cytokine production and cell-surface molecule expression of keratinocytes. The effects of @entity4155 were compared with those of @entity379 , which is also derived from activated T cells and is a strong stimulator for keratinocytes. @entity4155 enhanced the mRNA and protein production of the proinflammatory cytokines @entity650 and @entity687 in a concentration-dependent way, and induced a weak expression of @entity2071 and HLA-DR. The production of @entity1192 and @entity8252 was not altered. @entity379 augmented the production of @entity650 , @entity687 , and @entity8252 and strongly induced both cell-surface molecules. @entity4155 and @entity379 showed marked synergism in the stimulation of @entity650 and @entity687 protein secretion and, to a lesser extent, in the induction of @entity2071 and HLA-DR expression. The majority of the CD4+ and CD8+ T cell clones derived from lesional psoriatic skin expressed @entity4155 mRNA, suggesting that skin-infiltrating T cells can produce this cytokine. This @entity4155 mRNA expression was detectable in T helper cell type 1 and type 2 and did not correlate with the @entity379 or @entity3646 production. In addition, @entity4155 mRNA is detectable in biopsies from lesional psoriatic skin, but not in nonlesional control biopsies. Our study indicates that @entity4155 is a proinflammatory cytokine, which could amplify the development of cutaneous @entity32 and may support the maintenance of chronic dermatoses, through stimulation of keratinocytes to augment their secretion of proinflammatory cytokines.
