Evaluating the effectiveness of @entity8671 in preventing the progression of @entity67 in @entity472 : A substudy of the @entity472 progression observation measuring effects of XXXX (ASTRONOMER) study.

@entity1 @entity8671 @entity472 @entity854 @entity67
BACKGROUND: Tissue Doppler imaging (TDI) is a noninvasive echocardiographic method for the diagnosis of @entity67 in @entity1 with varying degrees of @entity472 ( @entity472 ). Little is known however, on the utility of TDI in the serial assessment of @entity854 in @entity472 . OBJECTIVE: The aim of the current proposal was to examine whether treatment with @entity8671 was successful in improving @entity854 in @entity1 enrolled in the Aortic Stenosis Progression Observation Measuring Effects of @entity8671 (ASTRONOMER) study. METHODS: Conventional Doppler indices including peak early (E) and late (A) transmitral velocities, and E/A ratio were measured from spectral Doppler. Tissue Doppler measurements including early (E') and late (A') velocities of the lateral annulus were determined, and E/E' was calculated. RESULTS: The study population included 168 @entity1 (56    13 years), whose @entity472 severity was categorized based on peak velocity at baseline (Group I: 2.5-3.0 m/s; Group II: 3.1-3.5 m/s; Group III: 3.6-4.0 m/s). Baseline and follow-up hemodynamics, LV dimensions and diastolic functional parameters were evaluated in all three groups. There was increased @entity67 from baseline to follow-up in each of the placebo and @entity8671 groups. In @entity1 with increasing severity of @entity472 in Groups I and II, the lateral E' was lower and the E/E' (as an estimate of increased left ventricular end-diastolic pressure) was higher at baseline (p < 0.05). However, treatment with @entity8671 did not affect the progression of @entity67 from baseline to 3.5 year follow-up between @entity1 in any of the three predefined groups. CONCLUSION: In @entity1 with mild to moderate asymptomatic @entity472 , @entity8671 did not attenuate the progression of @entity67 .
