Induction of @entity3123 in @entity35 with XXXX : histopathology.

@entity3123 @entity5 @entity189 @entity73098 @entity35 @entity157 @entity652
The carcinogenicity of @entity73098 (HPOP) for @entity35 pancreas was evaluated. Two-week-old male LEW @entity35 were given a single ip injection of HPOP, 160 mg/kg body weight; the @entity35 were autopsied 4, 6, or 12 months later. Histologic examination showed that the pancreata contained multiple foci of atypical acinar cells and nodules of atypical acinar cells (AACN), acinar cell @entity652 , @entity189 , and @entity189 . The incidence of @entity189 was 77%. The @entity189 were composed of poorly differentiated acinar cells and ductlike structures. Pancreatic ducts were unaffected. The prominence of AACN, the histologic type of the @entity5 , and the absence of hyperplastic changes in ductal epithelium suggest that the @entity3123 were derived from acinar cells. The incidence of @entity157 and @entity652 was similar to that of localized @entity3123 . @entity5 of other organs were less frequent. HPOP has been shown to induce @entity3123 in hamsters but has not previously been reported to be a pancreatic carcinogen in @entity35 .
