Efficacy and safety evaluation of XXXX associated with other antioxidants in medical treatment of @entity545 : a case-control study.

@entity1 @entity2003 @entity270 @entity3522 @entity545 @entity4045 @entity102 @entity1502 @entity158
@entity545 ( @entity545 ) is a @entity102 involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with @entity1502 ( @entity4045 ) in combination with other antioxidants in 307 @entity1 with early-stage @entity545 . @entity1 were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 @entity1 , underwent treatment, whereas Group C was the control group (n=101). Treatment lasted 6 months and included the following: Group A: @entity4045 400 mg twice a day + propolis 600 mg/d + blueberry 160 mg/d + @entity270 600 mg/d + @entity3522 4% gel twice/a day + @entity4045 100 mg via perilesional penile injection/every other week (12 injections in all); Group B: the same treatment as Group A except for the penile @entity4045 injections. After the 6-month treatment course, we obtained the following results: actual mean decrease in plaque volume -46.9% and -24.8% in Group A and B, respectively (P<0.0001); mean curvature reduction -10.1   and -4.8  , respectively (P,0.0001); resolution of @entity158 in 67.6% and 67.2% of cases, respectively (P=0.961); recovery of normal @entity2003 in 56.09% and 23.5% of cases, respectively (P=0.005). After 6 months, progression of disease was observed in all @entity1 belonging to Group C: plaque volume +123.3%; curvature +15.7  ; no recovery of @entity2003 . The statistically significant results of our study show that multimodal treatment with @entity4045 in association with other antioxidants and topical @entity3522 is efficacious in treating early-stage @entity545 . Furthermore, treatment proved to be more effective when @entity4045 was administered both orally and by penile injection. No serious adverse effects occurred.
