Development of a preclinical model of XXXX in @entity1707 .

@entity1707 @entity296 @entity308 @entity82 @entity63 @entity1347 @entity920 @entity1562 @entity432 @entity850
A number of promising therapies for @entity296 are emerging, and the role of translational research in testing the efficacy and safety of these agents in relevant clinical models has become important. The goal of this study was to develop a chronic model of @entity296 in a large animal model. In this study, 40 consecutive @entity1707 were initially enrolled. To induce progressive @entity850 , a plastic occluder with a fixed diameter of 1.0 mm fitted with an 18-gauge @entity920 wire was placed around the proximal @entity1347 ( @entity1347 ) coronary artery. Coronary angiography, hemodynamic measurements, and echocardiography were performed at 2 wk and 1, 2, and 3 mo. Overall mortality was 26% at 3 mo, and up to 80% of the @entity1707 showed total occlusion of @entity1347 at 1 mo. A significant @entity308 of peak LV pressure rate of rise (+dP/dt(max)) was observed in the animals showing @entity432 throughout the study. Left ventricular ejection fraction was also impaired, and the left ventricular volumes tended to be larger in the @entity1707 with occlusion. Approximately 10% of scar tissue was found in the @entity1347 occluded @entity1707 , whereas the coronary flow pattern in the rest of the area took the pattern of hibernating @entity1562 . At the same time, histological and protein analysis established the presence of @entity82 and ongoing apoptosis in the @entity63 area. In this model, the timing and incidence of total occlusion and low mortality offer significant advantages over other @entity296 models in conducting preclinical studies.
