Supratentorial cavernous haemangiomas and XXXX : a review of the literature and case series.

@entity1 @entity410 @entity302 @entity548
OBJECTIVES: To characterise the clinical features and response to treatment of supratentorial cavernomas associated with @entity302 . METHODS: A systematic review of the literature was carried out and a retrospective case series of @entity1 with cavernoma diagnosed by MRI and/or histology was compiled. @entity1 selection biases in the literature review were reduced as far as possible by selection of unbiased publications. RESULTS: In the literature, cavernomas were relatively less common in the frontal lobes. There were multiple cavernomas in 23% of cases. The main clinical manifestations were @entity410 (79%) and @entity548 (16%). The annual @entity548 rate was 0.7%. The outcome after excision was good with improvement in @entity410 in 92% of @entity1 . In the case series the surgical outcome was less favourable, reflecting inclusion of a higher proportion of @entity1 with intractable @entity302 . In both the literature review and the case series, outcome was poorer in cases with a longer duration of @entity410 at the time of surgery. CONCLUSIONS: The good surgical results, particularly in cases treated earlier, and the significant cumulative @entity548 rate, suggest that excision is the optimum treatment. However, these factors have not been examined prospectively and, despite the availability of several retrospective studies, the optimum treatment, particularly for non-intractable cases, will only be determined by a prospective study.
