Comparative analysis of gingival crevicular fluid b-glucuronidase levels in health, XXXX and @entity7278 .

@entity1 @entity102 @entity7278
BACKGROUND AND OBJECTIVES: Current methods available for periodontal disease diagnosis are seriously deficient in terms of accuracy, in the ability to predict ongoing or future disease activity and indeed in determining whether previously diseased sites are in an arrested phase or still active. One area that is receiving a great deal of attention is the biochemical investigation of gingival crevicular fluid (GCF). b-glucuronidase (bG) is one of the enzymes found in GCF that is involved in degradation of the ground substance and fibrillar components of host connective tissue. GCF bG activity might be a good indicator or predictor of periodontal disease activity. This study was conducted to estimate and compare the GCF bG levels in @entity1 with healthy periodontium, @entity102 , and @entity7278 . METHODOLOGY: Subjects were classified into three groups of 20 @entity1 each; healthy individuals, @entity102 , and @entity7278 . After recording the plaque index, gingival index and probing pocket depth, 1  L GCF was collected by placing a calibrated microcapillary pipette extracrevicularly and transferred to sterile plastic vials containing 350  L of normal saline with 1% bovine serum albumin. Analysis of bG was done by spectrophotometry. RESULTS: bG levels in GCF were significantly higher in @entity7278 group (mean value - 2.04743), followed by @entity102 group (mean - 1.11510) and healthy group (0.53643). CONCLUSION: Increased bG levels were observed in @entity1 with increased periodontal destruction, hence GCF bG levels can be used as biochemical marker for periodontal disease activity.
