Prognostic and clinical correlates of angiographically diffuse XXXX .

@entity1 @entity101 @entity6 @entity301 @entity453 @entity583
OBJECTIVE: To make a prospective assessment of the clinical and prognostic correlates of angiographically diffuse @entity301 . DESIGN: Angiographic vessel and extent scores were calculated in 228 clinically stable @entity1 (mean (SD) age, 60 (11) years; 43 @entity1 , 185 @entity1 ) undergoing prospective follow up for the composite end point of death and @entity583 . The effect on outcome of clinical variables (age, sex, previous @entity583 , @entity6 , smoking habit, systemic @entity101 , hypercholesterolaemia, ejection fraction) and angiographic variables (vessel and extent score) was evaluated by Cox's proportion hazard model. RESULTS: The vessel score was 3 in 34 @entity1 (15%), 2 in 78 (34%), 1 in 87 (38%), and 0 in 29 (13%). Median extent score was 60 (range 6-110; first quartile 40, third quartile 70). Forty one events (nine deaths and 32 @entity583 ) occurred over a median follow up period of 30 months. Age and extent score were the only multivariate predictors of outcome, but the latter provided 28% additional prognostic information after adjustment for the most predictive variables (gain in chi2 = 7, p < 0.01). A vessel score of 3 was associated with worse survival, while no significant discrimination was possible among the other groups. However, assignment of @entity1 to two groups according to an ROC curve derived cut off value for the extent score made it possible to obtain significant discrimination of survival even in cases with vessel scores of 0 to 2. Age and @entity6 were clinical markers of a higher extent score. CONCLUSIONS: The angiographic extent score is a powerful marker of adverse outcome independent of severity and the number of flow limiting @entity301 , and may reflect the link between clinical risk profile and diffusion of @entity453 . Thus it should be of clinical value for targeting aggressive preventive measures.
