@entity63 core and hypoperfusion volumes predict XXXX size in @entity514 PRIME.

@entity1 @entity64 @entity514 @entity63 @entity1188
OBJECTIVE: Within the context of a prospective randomized trial ( @entity514 PRIME), we assessed whether early imaging of @entity64 @entity1 , primary with CT perfusion, can estimate the size of the irreversibly injured @entity63 core and the volume of critically hypoperfused tissue. We also evaluated the accuracy of @entity63 core and hypoperfusion volumes for predicting @entity1188 volume in @entity1 with the target mismatch profile. METHODS: Baseline @entity63 core and hypoperfusion volumes were assessed prior to randomized treatment with IV tPA-alone vs. IV tPA   +   endovascular therapy (Solitaire stent-retriever) using RAPID automated post-processing software. Reperfusion was assessed with angiographic TICI scores at the end of the procedure (endovascular group) and Tmax >6s volumes at 27-hours (both groups). @entity1188 volume was assessed at 27-hours on non-contrast CT or MRI. RESULTS: 151 @entity1 with baseline imaging with CT perfusion (79%) or multimodal MRI (21%) were included. The median baseline @entity63 core volume was 6 ml (IQR 0-16). @entity63 core volumes correlated with 27-hour @entity1188 volumes in @entity1 who achieved reperfusion (r = 0.58, P <0.0001). In @entity1 who did not reperfuse (<10% reperfusion), baseline Tmax>6s lesion volumes correlated with 27-hour @entity1188 volume (r=0.78; P=0.005). In Target mismatch @entity1 , the union of baseline core and early follow-up Tmax>6s volume (i.e. predicted @entity1188 volume) correlated with the 27-hour @entity1188 volume (r=0.73; P<0.0001); the median absolute difference between the observed and predicted volume was 13 ml. INTERPRETATION: @entity63 core and hypoperfusion volumes, obtained primarily from CT perfusion scans, predict 27-hour @entity1188 volume in acute @entity64 @entity1 who were treated with reperfusion therapies. This article is protected by copyright. All rights reserved.
