Comparison of XXXX and @entity1286 in the Prehospital Treatment of @entity662 .

@entity662 @entity1187 @entity1 @entity5733 @entity63 @entity1242 @entity26 @entity117 @entity158 @entity1286 @entity551 @entity3575
UNASSIGNED: In the treatment of @entity1187 , reduction of sympathetic stress and @entity5733 release is an important therapeutic goal. One method used to achieve this goal is @entity158 reduction through the systemic administration of analgesia. Historically, @entity1286 has been the analgesic of choice in @entity63 @entity158 . This randomized double-blind controlled trial seeks to prove the utility of @entity3575 as an alternate first-line analgesic for @entity662 in the prehospital setting. Successive @entity1 who were treated for suspected @entity63 @entity662 in the emergency medical services system were considered eligible. Once @entity662 was confirmed, @entity1 received @entity26 , @entity117 , and @entity1242 therapy. If the @entity662 continued the @entity1 was randomized in a double-blinded fashion to treatment with either @entity1286 or @entity3575 . @entity158 scale scores, necessity for additional dosing, and rate of adverse events between the groups were assessed every 5 minutes and were compared using t-testing, Fisher's Exact test, or Analysis of Variance (ANOVA) where appropriate. The primary outcome of the study was incidence of @entity551 and the secondary outcome was @entity158 reduction as measured by the visual analog score and numeric rating score. A total of 207 @entity1 were randomized with 187 @entity1 included in the final analysis. Of the 187 @entity1 , 99 were in the @entity1286 group and 88 in the @entity3575 group. No statistically significant difference between the two groups with respect to @entity551 was found ( @entity1286 5.1% vs. @entity3575 0%, p = 0.06). Baseline characteristics, necessity for additional dosing, and other adverse events between the two groups were not statistically different. There were no significant differences between the changes in visual analog scores and numeric rating scale scores for @entity158 between the two groups (p = 0.16 and p = 0.15, respectively). This study supports that @entity3575 and @entity1286 are comparable in providing analgesia for @entity662 . @entity3575 appears to be a safe and effective alternative to @entity1286 for the management of @entity662 in the prehospital setting.
