Lens Status Influences the Association between XXXX Polymorphisms and Age-Related Macular Degeneration: Findings from Two Population-Based Studies in Singapore.

@entity28250 @entity1 @entity71328 @entity231 @entity9346 @entity735 @entity4050 @entity1020 @entity71329
AIMS: To determine the differential effects of genetic polymorphism in @entity4050 and @entity28250 on risk of @entity1020 ( @entity1020 ) between phakic vs. @entity735 . METHODS: 9,529 eyes of 4,918 @entity1 from the Singapore Malay Eye Study and Singapore Indian Eye Study were analyzed. @entity1 had detailed eye examinations, including slit-lamp examinations and dilated fundus photography. @entity1020 grading was performed according to the Wisconsin age-related @entity1020 grading system. Lens status was defined. Single nucleotide polymorphisms (SNPs) @entity71328 ( @entity9346 ) within @entity4050 and @entity71329 in @entity28250 were assessed. The main outcome measure was early @entity1020 or any @entity1020 . RESULTS: No significant associations between the @entity4050 @entity9346 genotypes and early @entity1020 were found in phakic individuals. In contrast, among pseudophakic/aphakic individuals, the @entity4050 @entity9346 risk genotypes were significantly associated with higher odds of early @entity1020 , with an OR of 1.57 (95% CI: 1.07-2.29) for GA genotype and 2.40 (95% CI: 1.25-4.61) for AA genotype, compared to those with GG genotype. There was significant interaction between pseudophakic/aphakic status and @entity4050 @entity9346 variant on risk of early @entity1020 (p = 0.037), adjusting for age, gender, and the first 5 genetic principal components. No significant interaction was found between lens status and @entity28250 @entity71329 . CONCLUSIONS: @entity4050 genetic polymorphism and pseudophakic/aphakic status may have a potential synergistic effect on early @entity1020 , suggesting roles for the complement system and related pathways in the pathogenesis of @entity1020 in eyes after @entity231 surgery.
