The antagonist of the @entity35709 / @entity30235 signaling pathway improves the severity of @entity8629 -stimulated @entity660 via inhibition of XXXX activity.

@entity32 @entity22943 @entity656 @entity568 @entity660 @entity35709 @entity1505 @entity12001 @entity4026 @entity30235 @entity3426 @entity35 @entity8629 @entity130
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is widely involved in cell migration, apoptosis and @entity32 . However, its exact mechanisms in @entity656 ( @entity656 ) remain unclear. The aim of this study was to explore the activity of the JAK/STAT signaling pathway in @entity660 , investigate the functional mechanisms of @entity656 in  vitro, and thus elucidate the underlying therapeutic effects for @entity656 in  vivo. The activation of the @entity35709 / @entity30235 signaling pathway and the expessions of @entity1505 , @entity3426 and @entity568 proteins were investigated in AR42J cells induced with @entity8629 and treated with either PBS, RPM, or @entity22943 . One group of cells was left untreated as a control group. Subsequently the activity of @entity4026 was evaluated. @entity35 were given RPM or @entity22943 just before the induction of @entity656 , the severity of which was assessed at 24 h. The findings revealed that the up-regulated expressions of @entity35709 / @entity30235 , @entity12001 protein were closely correlated with the transcription of @entity1505 , @entity3426 , and @entity568 in @entity8629 -stimulated cells. Administration of RPM or @entity22943 decreased the activity of @entity4026 and inhibited the release of @entity1505 , @entity3426 , and @entity568 . The reflective markers of severity of @entity656 were also decreased by RPM or @entity22943 treatment compared to @entity656 @entity35 . This study indicates that the @entity35709 / @entity30235 signaling pathway activity is an early event in pancreatic @entity130 . Therefore, early treatment with its inhibitors might be beneficial for attenuation of @entity660 in @entity656 .
