Testicular signaling is the potential target of @entity14911 -mediated subfertility in male XXXX .

@entity1 @entity14911 @entity251 @entity5412 @entity19 @entity4336 @entity28226 @entity2659 @entity21600 @entity42762 @entity7424 @entity48585 @entity14912 @entity63745
@entity14911 ( @entity14912 ) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and @entity1 . Although the adverse effects of @entity14912 on male fertility have been reported, the underlying mechanisms have not yet been elucidated. Here, for the first time, the effects of @entity14912 on testicular signaling, such as gonadotropin, growth hormone, insulin-like growth factor, and inhibins/activins were shown to be directly related to male subfertility. Sexually mature 8-wk-old @entity2659 male @entity19 were administered by gavages in @entity4336 oil daily with 0, 1, 5, or 10 mg/kg @entity14912 for 7, 14, or 21 days. Serum concentrations of @entity251 and epididymal sperm counts were significantly lower in the @entity19 after 21 days of the exposure to the highest dose compared with the controls. The expression levels of @entity7424 were considerably reduced on Day 21 in @entity19 exposed daily to 10 or 5 mg/kg @entity14912 . The transcript levels of the subunits of the testicular factors (i.e., inhibins and activins), @entity21600 , @entity5412 , and @entity48585 , were significantly lower on Day 21 of daily exposure to 10, 5, or 1 mg/kg @entity14912 . The mRNA expression levels of steroidogenic enzymes (i.e., StAR, @entity28226 , @entity42762 , 3beta-HSD, and @entity63745 ) were notably reduced. Therefore, @entity14912 -elicited subfertility in male @entity19 is manifested as progressive deterioration of testicular signaling.
