Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic XXXX : a resting-state functional magnetic resonance imaging study.

@entity1 @entity4365 @entity4531
OBJECTIVE: The objectives of this study were, first, to explore differences in brain activity between normal @entity1 and idiopathic @entity4531 ( @entity4531 ) @entity1 during asymptomatic periods; and, second, to determine whether administering repetitive transcranial magnetic stimulation (rTMS) to specific cortical regions would reverse any observed differences in brain activity and alleviate @entity1 symptoms. METHODS: Fifteen idiopathic @entity4531 @entity1 (nine drug-naive @entity1 ) and 14 gender- and age-matched healthy controls were enrolled. Resting-state functional magnetic resonance imaging was used to measure the @entity4365 ( @entity4365 ) in spontaneous brain activity during asymptomatic periods. Seven @entity1 received high-frequency (5 Hz) rTMS directed toward the leg area of the primary motor cortex. Scores on the International @entity4531 Study Group (IRLSSG) Rating Scale and @entity4365 values were measured before and after treatment. RESULTS: Compared with healthy controls, @entity4531 @entity1 showed lower @entity4365 in the sensorimotor and visual processing regions, and higher @entity4365 , parahippocampal and hippocampal gyri, left posterior parietal areas, and brainstem. These results were largely conserved when only drug-naive @entity1 were considered. After rTMS treatment, @entity4365 in several sensorimotor and visual regions were significantly elevated and IRLSSG Rating Scale scores decreased, indicating improved @entity4531 symptoms. CONCLUSIONS: High-frequency rTMS delivered to the leg area of the primary motor cortex may raise functional activity in the sensorimotor and occipital regions, leading to improve symptoms in @entity4531 @entity1 . These results provide novel insight into @entity4531 pathophysiology and suggest a potential mechanism for rTMS therapy in idiopathic @entity4531 @entity1 .
