Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously @entity101 XXXX are ameliorated by angiotensin blockade.

@entity1 @entity917 @entity101 @entity409 @entity9885 @entity35 @entity5433 @entity1063
OBJECTIVE: Elderly @entity101 @entity1 are characterized by blood pressure (BP) variability, impaired autonomic function, and vascular @entity409 and stiffness. However, the mechanisms causing these conditions are unclear. The present study examined the effect of angiotensin receptor blockers (ARBs) on aged spontaneously @entity101 @entity35 (SHR). METHODS: We surgically implanted telemetry devices in SHR and WKY at the age of 15 weeks (Young) and 80 weeks (Aged). Aged SHR were orally administered either @entity9885 or @entity917 once daily at 19:00  h (at the beginning of the dark period (active phase)) for 4 weeks to examine the effects on BP variability, impaired autonomic function, and vascular senescence. RESULTS: Aging and @entity101 in SHR additively caused the following: increased low frequency (LF) power of systolic BP, a decreased spontaneous baroreceptor reflex gain (sBRG), increased BP variability, increased urinary @entity1063 excretion, increased vascular senescence-related beta-galactosidase positive cells and oxidative stress. Treatment with @entity9885 or @entity917 significantly ameliorated these changes in aged SHR. However, @entity9885 ameliorated these changes in aged SHR better than @entity917 . The reductions in BP caused by @entity9885 in aged SHR were sustained longer than reductions by @entity917 . This result indicates longer-lasting inhibition of the AT1 receptor by @entity9885 than by @entity917 . CONCLUSION: ARBs ameliorated @entity5433 , BP variability, and vascular senescence in aged SHR. @entity9885 ameliorated the aging-related disorders better than @entity917 and was associated with longer-lasting AT1 receptor inhibition by @entity9885 . Thus, the magnitude of improvement of these aging-related abnormalities differs for ARBs.
