[Facilitating cervix dilatation of the non-pregnant uterus by intracervical administration of gels containing prostaglandin and XXXX ].

@entity1 @entity75 @entity6002 @entity72198 @entity460 @entity12374
In a prospective, randomised study, 50 non-pregnant @entity1 were treated intracervically with 3 ml 5% tylose, 50 micrograms @entity6002 , 100 micrograms @entity6002 gel, 3 ml 2.5 mM or 9.0 mM @entity12374 gel in order to soften the cervix 12-14 hours before diagnostic curettage. The gel was not used in a further 20 @entity1 . To objectively demonstrate the priming effect, the force required for dilatation of the cervical canal was measured in Newtons, using a mechanical tonometer both before gel application and before the operation. In comparison with the administration of @entity72198 only, the intracervical application of either @entity6002 gel or @entity12374 gel led to a significant improvement in cervical dilatability. Tylose alone had a slight but measurable effect on the cervix. An increase in @entity6002 from 50 micrograms to 100 micrograms or @entity460 molarity from 2.5 mM to 9.0 mM brought no further improvement in the dilatory effect. Dilatation-induced @entity75 could be avoided by preoperative cervical ripening. After application of @entity6002 , 3 out of 20 @entity1 experienced doses-dependent uterine cramps, while all @entity1 treated with @entity12374 gel were free of side effects. The intracervical administration of @entity6002 and @entity12374 gel allowed gentle dilatation of the non-pregnant cervix, thus lowering the risk of uterine lesions. Under clinical aspects, cervical priming facilitates diagnostic and therapeutic procedures, which, in exceptional cases, can be performed without anaesthesia.
