Chemopreventive effects of soy protein and purified soy @entity6400 on @entity106 -induced XXXX in female @entity35 .

@entity8139 @entity3653 @entity670 @entity5 @entity189 @entity106 @entity35 @entity6400
There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female @entity35 , mainly because of different rodent models that are used in chemoprevention studies. The present study was undertaken to compare the @entity5 -preventative effects of soy protein isolate (SPI) and two of its @entity6400 in a "standard" model that had been used for the identification of many chemopreventive agents. Six groups of female @entity35 were provided with modified cornstarch AIN-76A diets supplemented as follows: no additional agents (control), purified @entity670 (200 mg/kg diet), purified @entity8139 (200 mg/kg diet), @entity670 + @entity8139 (100 mg/kg diet each), SPI containing normal levels of @entity6400 (SPI-n), or SPI depleted of @entity6400 (SPI-d). @entity189 were induced by @entity3653 ( @entity106 ) introduced 1 wk after the animals began consuming the experimental diets. At the end of the study (120 days after @entity106 treatment), no significant differences were found among the six groups with respect to @entity5 incidence or survival, nor was there a significant @entity5 multiplicity in the @entity670 or @entity670 + @entity8139 group. However, there was a 32% @entity5 multiplicity in the @entity8139 and SPI-n groups relative to the control group (P < 0.05). The most effective diet was SPI-d, which produced a 50% @entity5 multiplicity relative to the control (P < 0.01). The difference between the SPI-d group and the @entity8139 or SPI-n group was not significant. Median @entity5 latency was increased from 53 days in the control group to 68 days in the @entity8139 group and to 72 days in the SPI-d group, but these differences were not statistically significant. These results show that @entity8139 and SPI (with normal or low levels of @entity6400 ) are effective inhibitors of @entity106 -induced @entity5 in adult @entity35 .
