Effects of @entity2644 , @entity7652 and @entity1855 on @entity526 heat-labile enterotoxin-induced intestinal hypersecretion in XXXX ileal loops.

@entity268 @entity7652 @entity11922 @entity1855 @entity95 @entity2644 @entity526 @entity5579
The effects of @entity2644 ( @entity5579 ), @entity7652 and @entity1855 on intestinal hypersecretion in the @entity95 ileal loop model by the heat-labile enterotoxin (LT) of @entity526 were studied in relation to their ability to inhibit the stimulation of intestinal adenylate cyclase (AC) by LT. @entity5579 5 mg by the intraluminal (i.1.) route and 4 mg/kg by the intramuscular (i.m.) route significantly reduced LT-induced intestinal hypersecretion. @entity7652 (10 mg) exerted an inhibitory effect, but only after i.1. administration, whereas @entity1855 did not exert any significant inhibitory effect when administered either i.1. (2.5 mg) or i.m. (4 mg/kg). At concentrations of (0.17-1.34) X 10(-3) M @entity5579 , the anti-secretory effect of @entity5579 correlated with its inhibitory effect on @entity95 LT-stimulated intestinal AC. Inhibition of @entity268 synthesis was probably not involved in the mechanism of action of the two other substances. These results indicate that @entity5579 and @entity11922 in general are efficient drugs for reducing LT-induced intestinal hypersecretion and could represent a model for synthesis of new anti-secretory drugs with no tranquiliser side effects.
