Gender difference in @entity1254 associated with XXXX .

@entity1 @entity1254 @entity29124 @entity65
BACKGROUND: It is important to identify @entity65 in @entity1 at high risk. To include genetics into routine cardiological @entity1 has therefore been discussed recently. We wanted to evaluate the association between high-molecular weight @entity1254 and cardiovascular risk, and secondly in the same population evaluate if specific genotype differences regarding risk could be observed, and thirdly if gender differences could be seen. METHOD: Four hundred seventy-six elderly @entity1 recruited from a rural community were included. All @entity1 underwent a clinical examination, echocardiography, and blood sampling and the single nucleotide polymorphism (SNP) ( @entity29124 ) of @entity1254 was analysed. Follow-up time was 6.7 years. RESULTS: Those with high serum concentration of @entity1254 had a more 2 fold increased cardiovascular risk, and it might be that females exhibits even higher risk where a more than 5 fold increased risk could be seen. The result could be demonstrated even in a multivariate model adjusting for well-known clinical risk factors. However, as the sample size was small the gender differences should be interpreted with caution. In the genotype evaluation the C/C carriers of the female group had a more than 9-fold increased risk of @entity65 , however the confidence interval was wide. Such genotype difference could not be found in the male group. CONCLUSION: High level of @entity1254 was associated with increased cardiovascular risk. Also a gender difference in the genotype evaluation could be seen where the C/C carriers obtained higher risk in the female group but not in the male group. Thus, in order to identify @entity1 at risk early, genetic analyses may add to the armamentarium used in the clinical routine. However, information should be regarded as hypothesis generating as the sample size was small and should stimulate further research in individualized cardiovascular prevention and treatment.
