A study of four cases of extra-orbital XXXX with documentation of some unusual features.

@entity1 @entity5 @entity1711 @entity241 @entity406 @entity4483 @entity18871 @entity2277 @entity6175 @entity2280
AIMS: To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell @entity18871 . METHODS AND RESULTS: Sections of @entity406 -fixed paraffin-embedded specimens were studied by @entity6175 and @entity1711 , reticulin and immunohistochemical stains. Electron microscopy was carried out in two cases on tissue fixed in @entity406 . The age of the @entity1 ranged from 30 to 41 years. Two @entity1 presented with a soft tissue swelling in the left groin, one @entity1 had a left axillary soft tissue lump and one @entity1 presented with a parotid lump. All lesions were well circumscribed and contained variably cellular and vascularized tissue composed of round to spindle cells with a patternless arrangement, scattered multinucleate giant cells and pseudovascular spaces conforming to the description of @entity18871 . Mononuclear and multinucleate @entity5 cells were both positive for @entity2277 and @entity2280 ; one @entity5 exhibited focal @entity4483 protein and GFAP positivity. Both of the @entity5 examined by electron microscopy showed fibroblastic features, but in addition one contained cells having Schwannian features. All four @entity1 were well without recurrent disease on follow-up (average 25 months). CONCLUSION: @entity18871 shares many features with @entity5 and @entity241 and shows a wider distribution than initially recognized. Rarely, Schwannian differentiation may be observed in these @entity5 .
