Treatment of electrical XXXX in sleep: A pooled analysis of 575 cases.

@entity1 @entity75 @entity73 @entity2526 @entity1245 @entity302 @entity230 @entity734 @entity159
OBJECTIVE: @entity302 with electrical @entity159 in sleep (ESES) is a @entity302 with sleep-induced @entity302 discharges and acquired @entity73 or behavior. Treatment of ESES is assumed to improve cognitive outcome. The aim of this study is to create an overview of the current evidence for different treatment regimens in @entity1 with ESES syndrome. METHODS: A literature search using PubMed and Embase was performed. Articles were selected that contain original treatment data of @entity1 with ESES syndrome. Authors were contacted for additional information. Individual @entity1 data were collected, coded, and analyzed using logistic regression analysis. The three predefined main outcome measures were improvement in cognitive function, electroencephalography (EEG) pattern, and any improvement (cognition or EEG). RESULTS: The literature search yielded 1,766 articles. After applying inclusion and exclusion criteria, 112 articles and 950 treatments in 575 @entity1 could be analyzed. @entity734 ( @entity734 , n  =  495) were associated with improvement (i.e., cognition or EEG) in 49% of @entity1 , @entity1245 (n  =  171) in 68%, and @entity230 (n  =  166) in 81%. Surgery (n  =  62) resulted in improvement in 90% of @entity1 . In a subgroup analysis of @entity1 who were consecutively reported (585 treatments in 282 @entity1 ), we found improvement in a smaller proportion treated with @entity734 (34%), @entity1245 (59%), and @entity230 (75%), whereas the improvement percentage after surgery was preserved (93%). Possible predictors of improved outcome were treatment category, normal development before ESES onset, and the absence of @entity2526 . SIGNIFICANCE: Although most included studies were small and retrospective and their heterogeneity allowed analysis of only qualitative outcome data, this pooled analysis suggests superior efficacy of @entity230 and surgery in @entity75 with ESES.
