Influence of @entity32 on the postnatal maturation of primary sensory neuron phenotype in XXXX .

@entity35 @entity32 @entity7504 @entity4655
The influence of early @entity32 upon the postnatal development of @entity35 primary sensory neuron subtypes was investigated. Lumbar dorsal root ganglia (DRG) were immunostained for @entity4655 ( @entity4655 ), neurofilament (NF200), and isolectin B4 (IB4) binding. Proportions of each subpopulation were measured at postnatal day (P) 0, P3, P7, and @entity7504 in normal pups and in those that had received a unilateral hindpaw carrageenan injection at P1. The effects were compared with those following a similar injury in adults. Both the IB4 (positive [+ve]) and NF200+ve cell populations increased postnatally (IB4+ve: 23 +/- 1.6% to 32.6 +/- 1.3%; NF200+ve: 33.8 +/- 1.2% to 43.3 +/- 1.9%), whereas the population of @entity4655 +ve cells stayed the same. @entity32 , the rise in IB4+ve binding occurred earlier but was the same as that in controls by @entity7504 . The @entity4655 +ve population increased at 2 and 6 days after carrageenan in neonates, because of an increase in both small @entity4655 /IB4 and larger @entity4655 /NF200 double-labeled cells, but was normal by 3 weeks. Carrageenan in adults caused an increase in @entity4655 /IB4 cells only. The effects of @entity32 differ in neonatal and adult DRG. Neonatal @entity32 causes @entity4655 upregulation in both small and large cells and accelerates the postnatal increase in IB4 binding. These effects might influence subsequent central development.
