Critical Review of Clinical Practice Guidelines for Fertility Preservation in Teenagers and Young Adults with XXXX .

@entity5 @entity1 @entity249
UNASSIGNED: Purpose: The 5-year survival of teenagers and young adults (TYAs; 13-24 years old) with @entity5 has continued to rise, but as a result more @entity1 experience late effects of treatment, such as @entity249 . Advice regarding fertility preservation in relation to @entity5 is provided in numerous clinical practice guidelines, but the rigor of their development is unclear. Methods: A systematic search was undertaken for clinical practice guidelines regarding fertility preservation in TYAs with @entity5 . All guidelines were reviewed according to the Appraisal of Guidelines for Research and Evaluation (AGREE-II) criteria. Five out of 13 identified guidelines scored over 75% in the "rigor of development" section and were further appraised. Content, scope, and consistencies between recommendations were also examined. Results: All five of the reviewed guidelines encouraged oncologists to have discussions with their @entity1 about potential fertility issues associated with treatment and available fertility preservation methods. The cryopreservation of sperm, oocytes, and embryos were all recommended as first-line interventions in postpubertal @entity1 . Recommendations surrounding pre- or peripubescent adolescents were few, with many techniques only recommended as part of a clinical trial. The risk of subfertility associated with different treatment regimens was poorly described. Conclusions: The methodology and development of guidelines describing fertility preservation in TYA @entity5 @entity1 varied greatly. Methodological quality did not clearly influence key recommendations. Those involved with the development of guidelines are encouraged to clearly define their development methods to allow users to be confident of the quality.
