Lung damage in experimental pleurodesis induced by XXXX or talc: 1-year follow-up.

@entity548 @entity4 @entity7292 @entity95 @entity133
STUDY OBJECTIVE: To compare the lung damage caused by intrapleural @entity7292 (SN) with that caused by talc over a 12-month period. DESIGN: One hundred forty @entity95 received an intrapleural injection of 0.5% SN or 400 mg/kg talc slurry in 2 mL saline solution. Groups of 10 @entity95 were killed after 1, 2, 4, 6, 8, 10, or 12 months. The macroscopic pleurodesis, microscopic lung changes (ie, collapse, @entity548 , and @entity4 ), and cellular infiltrates (number and proportion of cells) were graded on a scale of 0 to 4. RESULTS: The mean (+/- SEM) adhesion score after SN injection (3.3 +/- 0.1) was higher (p < 0.001) than that after talc injection (2.3 +/- 0.1). The mean @entity133 score was greater (p < 0.001) 1 month after SN injection (2.2 +/- 0.3) than after talc injection (0.2 +/- 0.1) and was similar from the second month on. The degree of @entity548 , by @entity133 score, (SN injection, 0.2 +/- 0.1; talc injection, 0.2 +/- 0.0) and @entity4 (SN injection, 0.4 +/- 0.1; talc injection, 0.3 +/- 0.1) was minimal in both groups (p > 0.05). One month after the injection, the total number of inflammatory cells was greater (p < 0.001) in @entity95 that had received SN injections (2.7 +/- 0.3) than in those that had received talc injections (1.2 +/- 0.1). From the second month on, cellularity decreased and became similar in both groups. The cellular profile was different, with a predominantly neutrophilic reaction after talc injection and a predominantly eosinophilic reaction after SN injection. CONCLUSIONS: @entity95 injected with intrapleural 0.5% SN had significantly higher scores for adhesions than did those that had received talc injections, with mild and reversible @entity133 and an eosinophilic responses, conditions showing a clear tendency to normalize with time.
