@entity342 Modulates Functions of Endothelial Progenitor Cells through Activated XXXX Signaling.

@entity21046 @entity586 @entity31425 @entity301 @entity5738 @entity342 @entity24319 @entity587 @entity3800
Researches show that @entity3800 have important effects on migration of endothelial cells and endothelial protection in @entity301 . Endothelial progenitor cells (EPCs) as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection. The relationship between @entity342 and the functions of EPCs has animated much interest and controversy. In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by @entity586 ( @entity587 ) and the molecular mechanisms as well. We found that @entity587 treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently. Moreover, microarray analysis was performed to explore how @entity587 changes the gene expression profiles of EPCs. We found 346 differentially expressed genes in @entity342 -treated EPCs. Angiogenesis-related genes like @entity5738 , @entity24319 , @entity21046 , and @entity31425 were identified to be regulated upon @entity587 treatment. Furthermore, the enhanced angiogenic and migratory abilities of EPCs after @entity587 treatment were inhibited by @entity5738 -siRNA transfection. In conclusion, our findings suggest that @entity587 markedly enhances the vessel forming ability and migration capacity of EPCs. @entity5738 signaling may be a possible pathway in this process.
