@entity3167 Supplementation Prevents High Fat Diet-Induced Insulin Resistance in XXXX through Transcriptional and Nontranscriptional Mechanisms.

@entity33944 @entity3167 @entity66 @entity3413 @entity1674 @entity35 @entity413
@entity3167 ( @entity33944 ) is a biomarker of @entity66 . In the present study, we tested the hypothesis that dietary @entity33944 may improve cardiometabolic indices. A high fat diet (HFD) + @entity33944 (50 or 400   mg/kg BW/day) was fed to @entity35 and compared with HFD + @entity3413 (10   mg/kg BW/day) or HFD alone for 12 weeks. Weights and serum biochemicals (lipid profile, oral @entity413 tolerance test, leptin, adiponectin, and insulin) were measured, and mRNA levels of insulin signaling genes were determined. The results indicated that low and high doses of @entity3167 (SA) improved metabolic indices, although only the oral @entity413 tolerance test, serum @entity1674 , leptin, and adiponectin were significantly better than those in the HFD and HFD + @entity3413 groups (P < 0.05). Furthermore, the results showed that only high-dose SA significantly affected the transcription of hepatic and adipose tissue insulin signaling genes. The data suggested that SA prevented HFD-induced insulin resistance in @entity35 after 12 weeks of administration through nontranscriptionally mediated biochemical changes that may have differentially sialylated glycoprotein structures at a low dose. At higher doses, SA induced transcriptional regulation of insulin signaling genes. These effects suggest that low and high doses of SA may produce similar metabolic outcomes in relation to insulin sensitivity through multiple mechanisms. These findings are worth studying further.
