Mild Deficits of Cortical Bone in Young Adults With Klinefelter Syndrome or XXXX Treated With Testosterone.

@entity1 @entity10478 @entity2357 @entity252 @entity79
CONTEXT: There are currently no data evaluating volumetric @entity79 ( @entity79 ), bone geometry, and body composition in adults with @entity252 ( @entity252 ) or @entity2357 who have been treated with T from adolescence. OBJECTIVE: To determine volumetric @entity79 , bone geometry using peripheral quantitative computed tomography (pQCT), and body composition using dual-energy x-ray absorptiometry (DXA) in @entity1 with classical @entity252 or @entity2357 treated with T from adolescence (age, <16 y), compared with matched controls. METHODS: Twenty subjects (12 @entity252 , eight @entity2357 ) and 20 controls underwent a pQCT (66% tibia, 4% radius) and total body DXA. RESULTS: Using adjusted regression models, there was reduced tibial cortical area (95% confidence interval [CI], -88.8 to -4.4 mm(2); P = .03) and thickness (95% CI, -0.98 to -0.10 mm; P = .02) in subjects. All other bone parameters were similar between groups. Subjects had significantly higher fat mass (95% CI, 1.6 to 14.9 kg; P = .02), trunk:leg fat ratio (95% CI, 0.09 to 0.60; P = .01), and visceral adipose mass (95% CI, 0.057 to 0.283 kg; P = .004). Lean mass was similar in both groups. Lean mass was positively associated with tibial cortical area and radial total, trabecular, and volumetric density (P < .05). CONCLUSION: This first report using pQCT and DXA in @entity1 with @entity252 or @entity2357 treated from adolescence showed normal volumetric @entity79 but reduction in cortical area and thickness, only at the 66% tibia site. Our study also demonstrated for the first time that @entity1 with @entity252 or @entity2357 have @entity10478 despite T treatment.
