Presence of simian virus 40 DNA sequences in egyptian XXXX with lymphoproliferative disorders.

@entity1 @entity981 @entity706 @entity5 @entity1072 @entity2033 @entity3052 @entity1778 @entity1892 @entity1583 @entity1893 @entity978 @entity1860
BACKGROUND: Although no definite risk factors have emerged for the different @entity1583 , a viral cause has been postulated. Several studies have detected SV40 DNA sequences in @entity5 tissues obtained from @entity1893 @entity1 . A link between SV40 and @entity1893 is biologically plausible because SV40 causes @entity1583 in laboratory rodents. METHODS: We investigated 266 Egyptian cases of different @entity1583 , for the presence of SV40 DNA using multiplex nested PCR technique. These cases consisted of 158 @entity1893 ( @entity1893 ), 54 @entity978 ( @entity2033 ), 26 @entity981 ( @entity981 ), 13 @entity3052 ( @entity3052 ), 8 @entity1072 ( @entity1072 ), 7 @entity1860 ( @entity1860 ), in addition to 34 subjects of control group. RESULTS: Our results have shown that SV40 DNA sequences were found in 53.8% of @entity1893 @entity1 , 29.6% of @entity978 @entity1 , and 40.7% of different types of @entity1778 cases. Frequency of SV40 DNA sequences was higher in @entity1893 @entity1 compared to the other @entity5 cases. Also, frequency of SV40 DNA sequences was significantly higher (p<0.05) in @entity1893 @entity1 than in the control group. Regarding the different histological types of @entity1893 , SV40 DNA sequences were detected frequently in diffuse large @entity1892 and in @entity706 . CONCLUSIONS: The present study suggests that SV40 DNA virus is significantly associated with @entity1893 and might have a role in the development of these @entity1583 . Polyomavirus SV40 may act as a cofactor in the pathogenesis of these @entity5 and this could lead to new diagnostic, therapeutic, and preventive approaches.
