XXXX with emphasis on Gleason's Grading: an institution based experience.

@entity1 @entity5 @entity263 @entity189
OBJECTIVE: To grade prostatic @entity189 according to the Gleason's Grading System and see whether the frequency of incidental @entity189 is significant. METHOD: Retrospective study of all consecutive cases of @entity263 diagnosed at Aga Khan University Hospital (AKUH) between January 1st, 1996 and December 31st, 1999. SETTING: The histopathology section of AKUH, Karachi. OBSERVATION: @entity263 comprised 14.2% of all prostate specimens. There were 3 types of specimens i.e. transurethral resection, suprapubic prostatectomies and core biopsies. The mean age was 72.1 years; 68.1% @entity1 were 65 years or older. The majority of the @entity5 were moderately differentiated (Gleason's scores 5,6 or 7). Grading was not possible in most core biopsies. The frequency of incidental @entity189 was 31.4%. CONCLUSION: Majority of @entity5 were moderate to poorly differentiated, indicating that @entity263 is an aggressive disease. The frequency of incidental @entity189 was also high emphasizing need for more aggressive prostatic evaluation in the vulnerable age group.
