[Birth cohort effect on prevalence of cardiovascular risk factors in XXXX . Experience in a Latin-american country.]

@entity1 @entity101 @entity6 @entity2299 @entity453
BACKGROUND: The prevalence of major risk factors associated to @entity453 has changed over time. Today, the frequency of @entity2299 , @entity101 and @entity6 has increased, while smoking has decreased. The birth cohort effect for @entity453 in subjects as an approximation of the true prevalence over time has not been studied in Latin-America. OBJECTIVE: To determine the trends in the prevalence of major risk factors for @entity453 by birth cohort effect in a high risk population. METHODS: We estimate the prevalence of @entity6 , smoking, @entity101 and @entity2299 from a prospective institutional registry (DREST registry) of @entity1 who underwent percutaneous coronary intervention for acute coronary event. Birth cohort effect was defined as a statistical, epidemiological and sociological methodology to identify the influence of the environment in the lifetime from birth by each decade. Univariate and multivariate analyses were performed adjusted by gender. RESULTS: Out of 3,056 subjects who were enrolled, 72% were male, with a median age of 61 years (interquartile range=53-69). @entity101 prevalence was 62.3%, for @entity6 it was 48.8%, for smoking it was 18.8% and for @entity2299 it was 48.8%. We observed an increase in prevalence for @entity6 and @entity2299 in each cohort according to birth decade, while there was a reduction in prevalence for @entity101 in the same decades. CONCLUSIONS: The prevalence of major cardiovascular risk factors has changed in time and the presence of time at birth effect is evident, possibly influenced by the environment's social conditions in each decade of life.
