[Expression of basic fibroblast growth factor during wound healing of XXXX fetal and adult skin and its significance].

@entity1 @entity540 @entity19
OBJECTIVE: To explore the expression of @entity540 during the wound healing of @entity1 fetal and adult skin and its significance. METHODS: We established the animal model of fetal scarless healing by transplanting full-thickness skin grafts from @entity1 fetus to a subcutaneous location on the athymic @entity19 recipient, and then making the linear incisions. The expression of @entity540 was observed in the normal adult skin, normal fetal skin and during wound healing by immunohistochemical method. The positive staining cells were counted under selected high-power focus randomly. RESULTS: @entity540 staining was not observed in the normal fetal skin and the wounded one. However, strongly positive staining was shown around the vessels in normal adult skin. Moreover, the positive straining became stronger in the wounded skin, especially in dermal fibroblasts and endotheliocytes. The number of positive staining cell was 2.1 +/- 0.1 in normal fetal skin, and 2.2 +/- 0.1, 2.1 +/- 0.3, 2.1 +/- 0.3 and 2.0 +/- 0.1 in the fetal skins after 12 hours, 1 day, 3 days and 7 days of wound respectively. The number of positive staining cell were 23.2 +/- 4.2 in normal adult skin and 40.5 +/- 3.6 in the wound adult skin. There was significant difference between the fetal skin and adult skin (P < 0.01). CONCLUSION: The negative expression of @entity540 in the fetal skin may be one of the important reasons for fetal scarless healing.
