Erythropoiesis in the XXXX of @entity2131 .

@entity1 @entity6582 @entity417 @entity548 @entity1307 @entity2131
The quantitative relationship between red cell volume, @entity1307 level, and erythropoiesis was evaluated in 43 @entity1 beings. Results in normal @entity1 were compared with studies in @entity1 with @entity417 from @entity2131 and with @entity6582 vera. The maximum @entity1307 excretion after @entity548 normal @entity1 was similar to the basal levels found in @entity1 with @entity417 of similar magnitude. Although @entity1307 values were low in @entity1 with @entity6582 vera, @entity548 evoked a normal response. In @entity1 anemic from @entity2131 , basal levels were elevated, and phlebotomy resulted in an increase consistent with the new level of @entity417 . These observations indicate that @entity1307 level is affected primarily by the degree of @entity417 and is not influenced by the duration of @entity417 . In normal subjects, a fivefold increase in urinary @entity1307 was associated with a doubling of erythropoiesis. Despite similar degrees of @entity1307 production, anemic @entity1 with evidence of bone marrow in the lower extremities had greater red cell production. In @entity1 with @entity6582 vera, red cell production was inappropriately elevated with regard to the urinary @entity1307 excretion. Bone marrow maturation time was not shortened in @entity1 anemic from @entity2131 to the same degree as in bled, normal volunteers. In addition to an adequate level of @entity1307 production, normal bone marrow function is necessary for maximal shortening of maturation time.
