Platelet transfusions in @entity5 XXXX with hypoproliferative @entity882 in the intensive care unit.

@entity5 @entity1 @entity882 @entity548
BACKGROUND: @entity882 is a frequent finding in critically ill @entity5 @entity1 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity548 in @entity5 @entity1 with hypoproliferative @entity882 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity1 with @entity882 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity1 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity548 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity548 events occurred in 40 @entity1 . About half of those @entity548 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity548 . The in-ICU mortality rate tended to be higher in @entity1 with severe ICU-acquired @entity548 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity5 @entity1 . The individual risk of ICU-acquired severe @entity548 appears hardly predictable with the depth of @entity882 .
