XXXX in @entity191 with and without @entity303 : a comparison with @entity195 , @entity1832 and controls.

@entity1 @entity3602 @entity2003 @entity146 @entity303 @entity73 @entity542 @entity191 @entity2845 @entity400 @entity179 @entity194 @entity1832 @entity195 @entity1315
@entity191 is a common @entity179 primarily characterized by @entity2003 , @entity400 and @entity2845 . @entity73 and @entity146 are frequent in @entity191 , with a 70% cumulative incidence of @entity303 . The aim of this cross-sectional study was to establish the pattern of @entity194 on MRI in @entity191 @entity1 with @entity303 . We used voxel-based morphometry (VBM) to provide an unbiased means of investigating brain volume loss. Whole brain structural T1-weighted MRI scans from @entity191 @entity1 with @entity303 ( @entity3602 , n = 26), @entity191 @entity1 without @entity303 (n = 31), @entity195 @entity1 (n = 28), @entity1 with @entity1832 ( @entity1832 , n = 17) and control subjects (n = 36) were acquired. Images were analysed using SPM99 and the optimized method of VBM. Reduced grey matter volume in @entity3602 @entity1 compared with controls was observed bilaterally in the temporal lobe, including the hippocampus and parahippocampal gyrus, and in the occipital lobe, the right frontal lobe and the left parietal lobe, as well as some subcortical regions. @entity191 @entity1 without @entity303 showed reduced grey matter volume in the frontal lobe compared with control subjects. There was significant grey @entity194 bilaterally in the occipital lobe of @entity3602 @entity1 compared with @entity191 @entity1 . In addition, significant @entity1315 , including the hippocampus and parahippocampal gyrus was detected in @entity195 relative to @entity3602 . No significant volumetric differences were observed in @entity3602 compared with @entity1832 . Thus, @entity191 involves grey matter loss in frontal areas. In @entity3602 , this extends to temporal, @entity542 , with @entity194 in @entity3602 being the only difference between the two groups. This provides important information about the pattern of @entity194 in @entity191 and @entity3602 .
