Hereditary pituitary prolactinomas: a new XXXX model.

@entity172 @entity251 @entity2013 @entity5 @entity5072 @entity977 @entity35 @entity652
@entity977 are known to occur spontaneously in several @entity35 strains, especially during aging. Here we report the occurrence of @entity652 ( @entity2013 ) in a new @entity35 model at an early age. The @entity652 were characterized by light and electron microscopy and histochemically by immunoperoxidase methods using specific antisera. Of the 53 pituitaries examined, one was normal, two were @entity5072 and the remainder were @entity652 . Among the latter, there were 37 @entity2013 (70%), 3 GH-producing @entity5 and 2 ACTH-containing @entity5 . One microadenoma produced both PRL and GH. The remaining 8 @entity652 were histochemically negative for all pituitary hormones. Serum PRL levels were elevated in both sexes while serum @entity251 was high in females and low in the males. The serum @entity172 levels were elevated in the males with @entity2013 . The @entity2013 appear to be transmitted as an autosomal dominant characteristic with incomplete penetrance and a greater incidence in the male.
