Is cyclooxygenase-2 important in XXXX ?

@entity268 @entity10178 @entity16538 @entity5230 @entity19775 @entity12698 @entity19 @entity5 @entity1185 @entity1489 @entity2918 @entity1426 @entity189 @entity3352 @entity105
Our studies have focused on the role of @entity1426 and its products in chemically and UV light-induced @entity19 models of @entity105 , with an emphasis on determining the importance of @entity2918 (PGs), which are synthesized by the two isoforms of cyclooxygenase (COX). Different types of @entity5 promoters elevate @entity10178 expression in keratinocytes, with little change in @entity16538 , suggesting that there are multiple signaling pathways by which @entity10178 expression can be regulated. We found that the expression of both COX isoforms is increased by treatment with PGs and that this autoregulation occurs via PG receptors linked to a @entity268 signaling pathway. We also observed that @entity10178 is constitutively upregulated in @entity1185 and @entity189 from either chemical initiation-promotion or UV-irradiation @entity105 experiments. We next investigated cis- and transacting factors required for @entity10178 expression. Two regions of the @entity10178 promoter, an E box and a nuclear factor-IL6 ( @entity19775 ) site, were identified as positive regulatory elements through transient transfection with luciferase reporter vectors containing various 5'-flanking regions of the promoter. We found that overexpression of @entity10178 in @entity5 maybe caused by a dysregulation in the expression pattern of the CCAAT/enhancer binding protein (C/EBP) family of transcription factors. To demonstrate the importance of PG synthesis in the @entity105 process, several nonsteroidal anti-inflammatory (NSAIDs) drugs were administered either orally or topically during UV @entity105 . Dietary administration of @entity3352 , @entity5230 , or the selective @entity10178 inhibitor @entity12698 prevented the development of UV-induced @entity1489 by up to 85%. In addition, @entity12698 had therapeutic efficacy in that it caused regression of preexisting @entity5 . Topical administration of @entity3352 after each UV exposure was also effective, suggesting that a postexposure approach to @entity1489 prevention maybe effective. Collectively, these studies suggest that @entity2918 play a critical role in @entity1489 development.
