Evaluation of discomfort and tolerability to bronchoscopy according to different sedation procedures with XXXX .

@entity1 @entity2 @entity1363 @entity158
UNASSIGNED: @entity1 frequently experience great discomfort during a bronchoscopy for the diagnosis of @entity2 . Sedation is generally recommended during bronchoscopy; however, few studies have evaluated the discomfort and tolerability of @entity1 to a bronchoscopy with regard to the administration procedures. The aim of the present study was to evaluate the discomfort and tolerability of @entity1 undergoing a bronchoscopy using different sedation procedures with @entity1363 . The retrospective survey of sedation during bronchoscopy involved the comparison of two periods: January-March 2012 (first period) and July-September 2012 (second period). A numerical rating score, which ranged between 1 (best) and 5 (worst) according to the subjective view of the @entity1 , was used to rate @entity1 discomfort, @entity158 , sensation, time and tolerability to the bronchoscopy. In the first period, 2.5 mg @entity1363 was administered prior to the initiation of surgery, and additional doses of @entity1363 was added in 2.5-mg increments whenever the @entity1 deviated from the target sedation level. In the second period, 2.0 or 3.0 mg @entity1363 was administered prior to the initiation of surgery, and additional @entity1363 doses were administered in 1.0-mg increments until the @entity1 were sedated to the target sedation level. In total, 60 and 68 valid responses were obtained in the first and second periods, respectively. The @entity1 in the second period exhibited significantly improved discomfort and @entity158 scores during the bronchoscopy and higher rates of consent to re-examination, as compared with the @entity1 in the first period (1.89  1.40 vs. 2.78  1.52, P<0.001; 1.48  1.13 vs. 2.00  1.37, P=0.005; 2.45  1.62 vs. 3.13  1.47, P=0.013, respectively). The amount of @entity1363 administered was significantly higher in the second period. There were no fatal complications during the bronchoscopy in either period. In conclusion, the present study observed that the administration of additional @entity1363 in small doses, until the target sedation level is achieved, is a safe procedure that is associated with significantly less discomfort and @entity158 during bronchoscopy and a greater consent to re-examination when compared with the administration of a fixed dose of @entity1363 .
