Role of XXXX in the Jak/ @entity4104 pathway in the @entity1 placenta: different mechanisms for preterm and term labor.

@entity1 @entity650 @entity3152 @entity4104 @entity5740
INTRODUCTION: To identify changes in @entity650 levels and its pathway (Jak/ @entity4104 ) in the @entity1 placenta during preterm and term labor, placental tissues were collected from primiparous @entity1 who underwent vaginal deliveries or cesarean sections in our hospital. The @entity1 were divided into three groups: @entity3152 (n  =  15), term labor (n  =  15), and term not in labor (n  =  15). MATERIAL AND METHODS: @entity650 levels were detected by ELISA in placental supernatant, and p- @entity4104 and @entity5740 protein was detected by Western blot. TUNEL was used to detect apoptosis in trophoblasts. HTR-8/SVneo cells were cultured after stimulation with @entity650 , and we measured p- @entity4104 , @entity5740 , and the rate of apoptosis. RESULTS: Expression of p- @entity4104 and @entity5740 in the placenta and trophoblast cells showed that @entity650 levels were highest in the @entity3152 group and lowest in the term not in labor group. The highest expression of placental @entity5740 protein was observed in the @entity3152 group. More apoptotic cells were found in the @entity3152 group than in the other two groups by TUNEL. @entity5740 and p- @entity4104 expression was significantly upregulated after stimulation by @entity650 in trophoblast cells in a dose-dependent manner. However, p- @entity4104 was significantly decreased after 50  ng/mL and 100  ng/mL @entity650 for 72  h. A significant increase of apoptosis was observed with treatment of 50  ng/mL @entity650 in HTR-8/SVneo cells. CONCLUSIONS: The role of the @entity5740 protein in the Jak/ @entity4104 pathway is to mediate different mechanisms for preterm and term labor processes in the placenta.
