[Chronological observation on intestinal histopathology and intraepithelial lymphocytes in the intestine of XXXX infected with Metagonimus yokogawai].

@entity35 @entity281 @entity1373 @entity194
The relationship between the intestinal histopathology and number and position of intraepithelial lymphocytes (IEL) was observed chronologically in the small intestine of @entity35 experimentally infected with Metagonimus yokogawai. Fifteen @entity35 were orally infected each with 3,000 metacecariae, and 3 were kept uninfected for controls. Three @entity35 each were sacrificed on the day 5, 10, 15, 24 and 70 post- @entity281 (PI) and samples of the small intestine, 5 cm, 10 cm, 20 cm and 70 cm posterior to the pylorus were taken. The samples were processed routinely and stained with Giemsa. The intestinal histopathology was severe during the day 5-15 PI and characterized by @entity194 , crypt @entity1373 , and decrease of villus/crypt height ratio. After the day 24 PI, the intestinal lesions showed some tendency of recovery. The number of IEL increased at the early stage of @entity281 , but decreased thereafter to a lower level than that of controls, with progression of the pathological changes. Then, the IEL number began to increase again after the day 24 PI. In control @entity35 , the great majority of the IEL were located at the basal region of the epithelium. During the early stage of @entity281 , however, a considerable proportion of IEL was found to have moved to the intermediate or apical region of the epithelium. From the above results, it is suggested that the change of IEL number and position during the course of M. yokogawai @entity281 should be closely related to the progression and recovery of the intestinal histopathology.
