XXXX subtyping relates with different molecular pathways.

@entity11833 @entity588 @entity10922 @entity3507 @entity5 @entity470 @entity8993 @entity2 @entity2225 @entity4910 @entity146 @entity876 @entity13456 @entity11092 @entity5822 @entity3 @entity72018 @entity105 @entity420 @entity1722
UNASSIGNED: @entity2 is one of the most common @entity5 in the world with a high mortality rate. We analyzed 45 surgical samples of the @entity420 , 13 with lymph node @entity3 . APC, @entity588 , @entity3507 , @entity72018 (LP34), @entity2225 , @entity5822 , @entity4910 , @entity470 , @entity11833 , @entity1722 , Ki67, @entity8993 , @entity11092 , @entity876 , RB and @entity10922 expressions were evaluated by immunohistochemistry (IHC). Higher Ki67, APC, @entity11833 expressions and lower @entity10922 expression were identified in advanced stages (IIA and IIIA) of @entity420 , which reflect a more @entity146 , less differentiated, possibly a non-TRU @entity420 . Acinar, micropapillary and BA/ @entity420 patterns were the most similar patterns and papillary was the most different pattern followed by solid pattern, according to expression of these markers. Different @entity420 patterns are engaged with different molecular pathways for @entity105 , based on the differences of expression. Acinar, BA/lepidic and micropapillary showed higher @entity10922 expression (type TRU), and papillary and solid patterns revealed less @entity10922 expression, exhibiting a non-TRU/bronchial phenotype. Solid pattern revealed lower @entity1722 and higher @entity470 and @entity11833 (this compared to papillary) expression; papillary higher @entity1722 and lower @entity11833 expressions; micropapillary higher RB expression; and acinar lower @entity11833 and higher @entity470 expressions. Ciclin D1 seems to have more importance in acinar and BA/lepidic patterns than in micropapillary. @entity11833 protein expression in micropapillary, solid and BA/lepidic patterns may indicate DNA repair activation. Inhibition of apoptosis could be explained by @entity588 overexpression, present in all @entity420 patterns. @entity13456 and @entity8993 were overexpressed in all patterns, which may have implications for drug resistance. Further studies are needed to interpret these data regarding to therapy response in advanced staged @entity2 .
