Protective effect of b-glucan on XXXX induced by lipopolysaccharide in @entity35 .

@entity5694 @entity1904 @entity568 @entity40109 @entity358 @entity35 @entity647
BACKGROUND/AIM: Lipopolysaccharide (LPS)-induced @entity5694 can cause serious organ damage such as @entity647 and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of b-glucan on inflammatory mediator levels and histopathological changes in LPS-induced @entity5694 . MATERIALS AND METHODS: Forty-seven male @entity35 albino @entity35 were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + b-glucan group (100 mg/kg b-glucan before LPS administration), and b-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of @entity568 , IL-8, @entity40109 ( @entity40109 ), and @entity1904 were measured in the serum at hours 0 (basal) and 12. The severity of @entity358 was assessed by an appropriate histopathological scoring system. RESULTS: Serum levels of @entity40109 in the LPS group at 12 h were significantly higher than in the other groups, whereas serum @entity568 levels in the LPS and LPS + b-glucan groups at 12 h were significantly decreased. The mean histopathological damage score of the LPS group was slightly higher than that of the LPS + b-glucan group. Moreover, mortality rate was significantly decreased in the LPS + b-glucan group versus the LPS group. CONCLUSION: b-glucan reduces @entity5694 -induced mortality and might be protective against @entity5694 -induced @entity358 .
