XXXX gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening: results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS).

@entity1 @entity6 @entity2204 @entity543 @entity121 @entity65 @entity165
BACKGROUND AND PURPOSE: Several studies have investigated the role of @entity2204 ( @entity2204 ) polymorphisms on carotid @entity121 ( @entity121 ) with conflicting results. The objective of this study was to use a large, community-based population to investigate associations between @entity2204 gene polymorphisms and @entity65 -associated phenotypes: @entity121 , @entity543 , and low- (LDL-C) and high-density lipoprotein @entity165 (HDL-C). METHODS: @entity2204 genotypes were determined in 1109 randomly selected community subjects with an equal @entity1 -to- @entity1 ratio and equal numbers in each age decile who were 27 to 77 years of age and had bilateral carotid B-mode ultrasound and @entity65 factor measurements. RESULTS: Multivariate analyses, stratified by sex, demonstrated an association between @entity2204 genotypes and LDL-C levels in @entity1 (P=0.03) and @entity1 (P<0.001). A significant linear trend in increasing LDL-C (beta=0.33 per unit change in genotype; SE=0.07; P<0.001) levels with increasing number of epsilon4 alleles across the epsilon3/epsilon3, epsilon3/epsilon4, or epsilon4/epsilon4 genotypes was observed in @entity1 but not in @entity1 . The associations were independent of age, diastolic blood pressure, and history of @entity6 . Multivariate analyses found a log-additive trend in risk of developing carotid plaque with increasing numbers of epsilon4 alleles across the epsilon3/epsilon3, epsilon3/epsilon4, and epsilon4/epsilon4 genotypes (odds ratio [OR], 1.72 per unit change in genotype; 95% CI, 1.05 to 2.80; P=0.03) in @entity1 . There was no association between plaque frequency and the epsilon4 allele in @entity1 . However, the epsilon2/epsilon3 genotype was shown to be associated with a lower OR (OR, 0.40; 95% CI, 0.17 to 0.91; P=0.03) for carotid plaques relative to the epsilon3/epsilon3 genotype in @entity1 . The associations were independent of age and standard vascular risk factors. There were no significant independent associations between @entity2204 genotypes and @entity121 in either @entity1 or @entity1 . CONCLUSIONS: Our data suggest that polymorphisms in the @entity2204 gene are significantly associated with LDL-C levels and increased risk of carotid plaque formation in @entity1 but not @entity121 in either @entity1 or @entity1 .
