XXXX degradation in @entity6975 fed-batch cultivations.

@entity6975 @entity2227 @entity653 @entity798 @entity1391 @entity3104
@entity798 (CA) is an important antibiotic that is produced by @entity6975 . CA is unstable and product degradation has turned out to have a major impact on product titers in fed-batch cultivations. Three different types of experiments have been used to elucidate CA degradation under fed-batch cultivation conditions. First, the influence of individual medium compounds was examined. Second, degradation was monitored during the exponential growth phase in batch cultivations. Third, CA degradation was studied in the supernatant of samples taken during a fed-batch. In addition, data from six fed-batch cultivations were studied to derive information about CA degradation during the production phase. These cultivations were based on a mineral medium, containing @entity653 , @entity2227 , @entity3104 , and @entity1391 as the main nutrients. The @entity3104 concentration had a large influence on the degradation rate constant. In addition, either changes in the substrate availability or high concentrations of @entity3104 or @entity653 cause a major increase in the degradation rate constant. Finally, a linear and a fuzzy logic model were made to predict CA degradation rates in these fed-batches.
