XXXX Accelerates Wound Healing Process by Modulating Gene Expression of @entity17533 , @entity16309 , and @entity6930 in Normoglycemic @entity35 .

@entity17533 @entity6930 @entity4045 @entity16309 @entity1502 @entity35
BACKGROUND: Although numerous recent advances in wound healing have highlighted the importance of adjunct therapies in maximizing healing potential, abnormal wound healing continues to cause significant expense, morbidity, and mortality. OBJECTIVE: This study examines the effects of @entity1502 ( @entity4045 ) on wound healing. HYPOTHESIS: We are expecting that @entity4045 administration can increase biomechanical parameters and modulate @entity17533 ( @entity17533 ) and @entity16309 , and matrix metalloproteinase inhibitor-1 ( @entity6930 ) in normoglycemic (NG) @entity35 model of wound healing. METHODS: Each @entity35 received an identical wound from a full-thickness incision on its back. Experimental @entity35 received systemic administration of @entity4045 . All @entity35 underwent examinations for biomechanical and polymerase chain reaction(PCR) analysis. Maximum stress and energy absorption were calculated as the biomechanical examinations. Expressions of @entity17533 , @entity16309 and @entity6930 genes were evaluated semi-quantitatively by reverse transcriptional (RT)-PCR. RESULTS: @entity4045 significantly improved biomechanical parameters. Quantification of @entity17533 , @entity16309 , and @entity6930 showed that @entity4045 significantly reduced gene expressions of @entity17533 and @entity16309 . There was a significant increase in @entity6930 gene expression. CONCLUSION: Systemic administration of @entity4045 significantly accelerated the wound healing process in NG @entity35 .
