Time-course changes in pancreatic laboratory and morphologic parameters in two different XXXX models in @entity35 .

@entity788 @entity656 @entity6140 @entity26 @entity6139 @entity1234 @entity35 @entity1445
The aim of this work was to study in @entity35 the temporal course of laboratory parameters and morphologic features in @entity656 induced by @entity6139 ( @entity6140 -8) or by a closed duodenal loop. @entity788 was induced either with an @entity1445 of @entity6140 -8 (3 x 75 micrograms/kg at 1 h intervals) or by ligation of the duodenum on both sides of the bilio-pancreatic duct. The animals were examined at 0, 2, 4, 8, 16 and 24 h after AP induction. In @entity6140 -8-induced @entity656 , the pancreatic weight/body weight ratio (8.2 +/- 1.1 mg/g) and the amylase level (44.8 +/- 7.5 x 10(3) U/ml) were significantly increased vs. the controls (4.5 +/- 0.8 mg/g and 3.3 +/- 0.2 x 10(3) U/ml, respectively) 2 h after the intervention. The plasma @entity6140 was significantly increased at 4 h (4.55 +/- 1.7 pM) and remained elevated thereafter. The tissue @entity1234 concentration was significantly elevated at 8 h (0.28 +/- 0.07 mumol/mg pancreas) vs. the controls (0.20 +/- 0.02 mumol/mg pancreas). In closed duodenal loop-induced @entity656 , the ratio pancreatic weight/body weight steadily increased during the study; it reached its maximum level at 24 h (7.1 +/- 0.5 mg/g) vs. the sham-operated control (4.8 +/- 0.9 mg/g). The serum amylase level was significantly elevated at 2 h (47.1 +/- 9.3 x 10(3) U/ml), and then decreased steadily. Plasma @entity6140 values were significantly higher than the controls throughout the study. A significant increase in the tissue @entity1234 concentration (0.94 +/- 0.15 mumol/mg vs. 0.20 +/- 0.01 mumol/mg pancreas) appeared at 4 h. Our data indicate that in @entity6140 -8-induced @entity656 the laboratory signs of @entity788 are most expressed at 4 h, whereas the morphologic changes culminate 8 h, following the last @entity6140 injection. In closed duodenal loop-induced @entity656 , the histologic findings showed a progressive deterioration. Endogenous @entity6140 and @entity26 -derived free radicals seem to play a role in the pathogenesis of both types of @entity656 .
