Gene expression profiles in stage I uterine @entity189 in comparison to grade 3 and grade 1 stage I XXXX .

@entity1204 @entity1 @entity44477 @entity5 @entity189 @entity4348
BACKGROUND: @entity1204 is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine @entity189 (USC) has outcomes similar to early stage high grade @entity4348 ( @entity44477 ) than to early stage low grade @entity4348 ( @entity44477 ). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n=11) relative to stage I @entity44477 (n=11) and stage I @entity44477 (n=11), respectively. METHODOLOGY/PRINCIPAL FINDING: We found that the expression difference between USC and @entity44477 , as measured by the number of differentially expressed genes (DEGs), is consistently less than that found between USC and @entity44477 . Pathway enrichment analyses suggested that DEGs specific to USC vs. @entity44477 are enriched for genes involved in signaling transduction, while DEGs specific to USC vs. @entity44477 are enriched for genes involved in cell cycle. Gene expression differences for selected DEGs are confirmed by quantitative RT-PCR with a high validation rate. CONCLUSION: This data, although preliminary, indicates that stage I USC is genetically similar to stage I @entity44477 compared to stage I @entity44477 . DEGs identified from this study might provide an insight in to the potential mechanisms that influence the clinical outcome differences between @entity1204 subtypes. They might also have potential prognostic and therapeutic impacts on @entity1 diagnosed with uterine @entity5 .
