The role of primary surgical treatment in young XXXX with squamous cell carcinoma of the larynx: a 20-year review of 34 cases.

@entity1 @entity5 @entity1544 @entity3 @entity285
BACKGROUND: The aim of this study was to investigate the clinical patterns in young Chinese @entity1 (less than 40  years old) with @entity1544 ( @entity1544 ) and the outcome of primary open surgery. METHODS: Thirty-four young @entity1 , with histologically confirmed @entity1544 between 1985 and 2005 at Qilu Hospital and Affiliated Hospital of Weifang Medical College, who underwent primary open surgery were retrospectively evaluated according to the clinical patterns in comparison with 374 non-young @entity1 (older than 40  years). The Kaplan-Meier method was used to calculate the survival rate. The relevance of smoking, @entity5 location, @entity5 -node- @entity3 (TNM) staging, lymph node involvement, @entity5 size, and histological differentiation to overall survival was tested by multivariate analysis. RESULTS: There was a significantly higher rate of smoking (p   =   0.020) in the non-young @entity1 compared to the young @entity1 , but no significant difference was observed in @entity285 consumption, @entity5 location, @entity5 size, TNM staging, lymph node @entity3 , histological grade, and 5-year overall survival. One-year survival rates were 100  %, 3-year survival rates were 79.41  %, and 5-year survival rates were 67.65  %. In the multivariate analysis, lymph node involvement (p   =   0.006), @entity5 stage (p   =   0.022), and @entity5 size (p   =   0.004) proved to be significant predictors of overall survival. CONCLUSIONS: The incidence of smoking was significantly higher in non-young @entity1 compared to young @entity1 . Primary surgery with or without radiotherapy may provide a value treatment option for young @entity1544 . Nodal status, @entity5 stage, and @entity5 size were the primary determinants of overall survival in multivariate analysis. These data may provide useful information for counseling and treatment planning.
