Local application of @entity94 compensates callus deficiency after acute soft tissue XXXX --results using a limb-shortening distraction procedure in @entity95 tibia.

@entity174 @entity94 @entity95 @entity130
Acute soft tissue @entity130 influences callus formation and @entity174 healing. Several studies showed a relationship between angiogenesis and bone formation during distraction osteogenesis. The purpose of this study was to investigate the influence of controlled release of @entity94 ( @entity94 ) on callus formation in a limb-shortening distraction procedure after acute compartment syndrome. Acute soft tissue @entity130 with critical increased compartment pressure was generated in 22 @entity95 , and the limb was shortened simulating @entity174 site debridement. In the test group (n=11), a @entity94 -coated collagen matrix was locally applied around the @entity174 , while no collagen was applied in the control group (n=11). Following 10 days in limb shortening, a gradual distraction of 0.5   mm/12   h was performed using an external fixation device and followed up for 40 days. Osseous consolidation occurred in all animals. Average callus diameter (1.54        0.8 vs. 1.27        0.14   mm) and torsional strength (72% vs. 46% of normal) were significantly higher in the test versus the control group. Blood vessel formation increased with a significantly higher number of vessels (6.3 vs. 3.81/mm2 ) and larger cross-sectional area (>40     m, 90.5% vs. 86%) in the test versus control group. The results showed that locally applied @entity94 stimulates @entity174 healing after acute soft tissue @entity130 and might be an option for @entity174 treatment in cases with severe soft tissue damage.
