Outcomes of Adjuvant Chemoradiation and Predictors of Survival After Extended Cholecystectomy in XXXX : a Single Institution Experience from an Endemic Region.

@entity1 @entity5 @entity1086
PURPOSE: The purpose of the study was to analyse outcomes with adjuvant concurrent chemoradiotherapy (cCRT) followed by adjuvant chemotherapy (AC) in radically resected @entity1086 ( @entity1086 ) in Indian @entity1 . METHODS AND MATERIALS: We retrospectively reviewed the records of @entity1086 @entity1 who received adjuvant cCRT after extended cholecystectomy (EC) between January 2007 and December 2011. Patterns of recurrence, disease-free survival (DFS), overall survival (OS) and adverse prognostic factors were evaluated. RESULTS: Thirty-two @entity1 were analysed. At a median follow-up of 53  months, 40  % of @entity1 had recurrence either locoregionally (12  %) or had distant metastases (28  %). The 5-year OS and DFS was 25 % and 53  %, respectively. When prognostic factors were evaluated, the median OS was 51 versus 23  months for node-negative (n   =   8) versus node-positive disease (n   =   24), not reached versus 34  months for stage 2 (n   =   4) versus for stage 3 (n   =   28), 46 versus 23  months for R0 (n   =   11) versus R1 resection (n   =   21), 51 versus 12  months (p   =   0.15) for well-differentiated (n   =   16) versus poorly differentiated @entity5 (n   =   8), and 10 versus 51  months for lymphovascular invasion presence (n   =   4) versus absence (n   =   28) (p   =   0.01). CONCLUSION: Outcome in Indian @entity1 with cCRT followed by AC is similar to that reported in the literature. Adjuvant cCRT followed by AC improves outcomes in @entity1 with R1 and node-positive disease. @entity5 , nodal positivity, poor differentiation, presence of perineural invasion and lymphovascular invasion are adverse prognostic features. Further research is required with treatment intensification in @entity1 with adverse prognostic factors to improve outcome.
