Characteristics of XXXX in centenarians.

@entity1 @entity8095 @entity527 @entity75 @entity1711 @entity10371 @entity191 @entity1710 @entity2314 @entity1832 @entity195
To investigate the characteristics of @entity2314 in the brains of centenarians, the autopsied brains and spinal cords from 23 cases were studied. Coronal slices were prepared from a section of the cerebral hemisphere, following the guidelines of the Consortium to Establish a Registry for @entity195 ( @entity195 ) (CERAD) and the consensus guidelines for the clinical and pathologic diagnosis of @entity1832 ( @entity1832 ). Spinal cord specimens were prepared at each segment from the third cervical to the third sacral segment. In all cases, we performed standard stainings of @entity1710 - @entity1711 , Kl  ver-Barrera, and Gallyas-Braak combined with Luxol fast blue/ @entity10371 , and @entity8095 (AS), phosphorylated tau (AT8) and beta-amyloid protein immunostainings. One-way ANOVA analysis, Chi-square or Fisher exact test were used for statistical analysis. Overall, AS-positive structures were found in 8 (34.8%) of our 23 centenarians, 6 (35.3%) of 17 demented @entity1 , and four (40%) out of ten @entity195 @entity1 . The frequencies of @entity75 in the brains with @entity527 ( @entity527 ) stage 0-A, B, and C were 27.7, 33, and 50%, respectively. No statistical differences were found among the frequencies of @entity75 in the subgroups of NFT stages I-II, III-IV, and V-VI (P=0.478). Most cases showed a widespread distribution of AS-positive structures except for one @entity1 , in whose brain only the medulla was involved. The distribution pattern of @entity75 was similar to that in @entity191 or @entity1832 , but the pigmented neurons in substantia nigra were relatively well preserved. Our findings indicate that there is a high frequency of @entity2314 in centenarians, @entity527 -positive and @entity75 may involve a synergistic interaction.
