Predictive factor of distant recurrence in locally advanced XXXX treated with concurrent chemoradiotherapy.

@entity1 @entity6461 @entity5 @entity957 @entity189 @entity3
OBJECTIVE: To identify prognostic factors in @entity1 with locally advanced @entity957 treated with concurrent chemoradiotherapy (CCRT). METHODS: We analyzed 108 @entity1 with FIGO stage Ib2-IVa @entity189 treated with CCRT between 1996 and 2003 at the University of the Ryukyus Hospital. @entity1 with a local @entity5 size of 4cm or more in diameter or lymph node enlargement were treated with CCRT. Disease-free survival (DFS) was estimated by the Kaplan-Meier method. The log-rank test was used to test differences in survival. Fisher's exact test was used for univariate analysis. The Cox proportional hazard model was used for multivariate analysis. RESULTS: The median age and the median follow-up were 50 years (range: 25-70 years) and 48 months (range: 4-102 months), respectively. The 4-year distant DFS of all @entity1 were 83%. Thirty-two of 108 @entity1 were diagnosed with recurrence. Twenty @entity1 had distant failure, of which 17 had only distant @entity3 , three @entity1 both distant and loco-regional recurrence, and the remaining 12 @entity1 recurred loco-regionally. @entity957 antigen ( @entity6461 ) immediately after CCRT was an independent predictive factor for distant recurrence on multivariate analysis. The 4-year distant DFS of these @entity1 was 62.5%, which was significantly worse than 89.2% in @entity1 with negative serum @entity6461 level (p=0.003). It should be noted that the distant @entity3 occurred within 6 months in six of the nine @entity1 . CONCLUSION: Positive serum @entity6461 immediately after the treatment was a predictive factor for distant recurrence. New strategies should be considered to control distant recurrence in this group of @entity1 .
