The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute XXXX .

@entity1 @entity131 @entity73 @entity772 @entity933 @entity22
OBJECTIVE: Following @entity131 , both @entity22 and @entity73 are common. Unfortunately, little is known regarding the potential associations between these 2 symptoms during acute recovery. This study sought to prospectively examine the relationship between ratings of @entity22 and serial cognitive assessments among @entity131 acute neurorehabilitation admissions. METHODS: @entity1 were consecutive admissions to a free-standing rehabilitation hospital following moderate to severe @entity131 (Median Emergency Department Glasgow @entity772 Scale = 7). @entity1 were assessed for sleep-wake cycle disturbance (SWCD) and cognitive functioning at admission and with subsequent weekly examinations. @entity1 were grouped on the basis of presence (SWCD+) or absence (SWCD-) of @entity22 for each examination; groups were equivalent on demographic and injury variables. Individual Growth Curve modeling was used to examine course of Cognitive Test for @entity933 performance across examinations. RESULTS: Individual Growth Curve modeling revealed a significant interaction between examination number (ie, time) and SWCD group (b = -4.03, P < .001) on total Cognitive Test for @entity933 score. The SWCD+ ratings on later examinations were predicted to result in lower Cognitive Test for @entity933 scores and greater @entity73 over time. CONCLUSIONS: This study has implications for improving neurorehabilitation treatment, as targeting @entity22 for early intervention may facilitate cognitive recovery.
