The treatment outcome depending on the extent of resection in skull base and spinal XXXX .

@entity5 @entity1 @entity3580
PURPOSE: The authors tried to assess the treatment outcomes depending on the extent of resection in axial @entity3580 and compare the outcome of two adjunctive therapies (external beam radiation therapy vs. stereotactic radiosurgery) following incomplete @entity5 resection in terms of @entity5 control. @entity1 AND METHODS: We retrospectively reviewed 30 consecutive @entity1 with @entity3580 involving skull base, sacrum and mobile spine between 1993 and 2008. Their initial treatments had different extent of resection. Wide resection was performed for 12 (40%), subtotal resection and adjunctive radiotherapy/radiosurgery for 12 (40%), while six @entity1 (20%) were solely treated with radiotherapy/radiosurgery. For these three groups, overall and progression-free survival rate were compared. RESULTS: The overall survival rate was 96% at 5  years and 67% at 10  years. Tumour progression-free survival (PFS) rates were 73% and 43% at 5 and 10  years, respectively. Local @entity5 progression was seen in 67% in all @entity1 , 58% in wide resection group, 67% in subtotal resection plus radiotherapy/radiosurgery group, and 75% in radiotherapy/radiosurgery group; however, this was not statistically significant (P   =   0.69). Neither the extent of resection nor @entity5 location significantly influenced overall and progression-free survival (P   >   0.05). With regard to the type of radiotherapy, @entity5 progression occurred in all lesions treated with external photon beam radiation therapy (EBRT) but only 38% of lesions treated with stereotactic radiosurgery (SRS) (P   =   0.003). CONCLUSIONS: Adjunctive radiotherapy/radiosurgery following subtotal resection showed comparable local control and survival to wide resection. SRS offered superior @entity5 control compared to EBRT.
