XXXX : A Systematic Review.

@entity1 @entity1353 @entity5 @entity2347 @entity189 @entity3
OBJECTIVE: @entity2347 is a @entity5 that represents <1% of all @entity5 . The submucosal location of laryngeal adenoid @entity189 (LACC) results in delayed presentation. Here, we present the first systematic review of reported cases of LACC to determine trends in presentation, diagnostic and treatment modalities, and @entity1 outcome. DATA SOURCES: PubMed, Web of Science, MEDLINE, and EMBASE databases. METHODS: A search of the above databases was done to identify articles reporting cases of LACC. The variables included in the analysis were @entity1 demographics, presenting symptoms, @entity5 location, imaging, treatment, follow-up time, recurrence, and outcome. RESULTS: A total of 50 articles and 120 cases were included in the review. The most common presenting symptom was @entity1353 (48.8%), followed by hoarseness (43.9%). LACC arose most frequently from the subglottis (56.7%). At presentation, 14.6% (13 of 89) of @entity1 had regional disease. The average follow-up time was 54.0 months. At follow-up, distant @entity3 was reported in 30 cases (33.3%). Surgery alone (43.3%) and surgery with radiotherapy (43.3%) were used most frequently and resulted in 57.1% and 55.3% of @entity1 alive with no evidence disease at follow-up, respectively. CONCLUSION: LACC was most often located in the subglottis. @entity1 commonly presented with @entity1353 and hoarseness. In this systematic review, surgery with radiotherapy and surgery alone were the most commonly employed treatment modalities, and both resulted in slightly more than 50% of @entity1 alive with no evidence of disease at follow-up.
