Ischemic neurophysiological changes of XXXX sciatic nerve in vitro.

@entity1 @entity63 @entity6883 @entity158 @entity35 @entity17401 @entity902 @entity855
PURPOSE: @entity1 with @entity63 always have a progressive reduction in nerve conduction resulting in a transient increase in sensation, such as @entity158 or @entity17401 . We examined the effect of acute complete @entity63 on neurophysiological functions in @entity35 and related electrophysiological changes in ischemic nerve with @entity6883 ( @entity855 ) administration. METHODS: The sciatic nerve of @entity35 was placed directly on 16 parallel 0.5 mm diameter @entity902 electrodes (5 mm interelectrode distance) in a Perspex chamber bathed in Ringer's solution. The stimulus was applied through the electrode at the rostral end of the nerve, and the action potential recorded along different recording electrodes towards the caudal end of the nerve. Measurements were recorded immediately upon initial nerve placing and then 5, 10, 15, 30, 60, 90 and 120 min after nerve placing. RESULTS: We observed two major components in the monophasic compound action potential of the sciatic nerve of @entity35 (A and B waves). Nerve conduction and amplitude of A and B waves underwent an initial increase followed by a reduction and after @entity855 administration, the transient augmentation of conduction velocity and amplitude in A and B waves disappeared. The median survival time of peripheral nerve was 60 min. CONCLUSION: At the onset of @entity63 , the membrane Na-K pump does not work resulting in an increase of threshold potential in nerve membrane. When @entity855 levels further decrease, nerve function progressively fails.
