Decrease in cerebral and cerebellar gray matter in essential XXXX : a voxel-based morphometric analysis under 3T MRI.

@entity1 @entity400 @entity194 @entity76
BACKGROUND AND PURPOSE: Though routine neuroimaging is usually normal in essential @entity400 (ET) there is clinical evidence of widespread involvement of central nervous system. This study aimed at determining morphological changes in brain of @entity1 with ET using voxel-based morphometry (VBM) analysis and also compare the subtypes of ET. METHODS: Clinical and imaging data of 20 @entity1 (5 @entity1 , 15 @entity1 ; mean age 38.2    16.5 years) of ET were collected prospectively. To determine areas of gray matter (GM) @entity194 , T1W volumetric MRI data of @entity1 were compared with 17 matched control subjects using VBM analysis with Statistical Parametric Mapping 5. RESULTS: Compared to controls, @entity1 showed scattered areas of cerebral and @entity76 . Voxel-wise analysis of @entity1 with and without head @entity400 showed widespread areas of @entity194 in cerebral hemispheres of @entity1 with head @entity400 . No difference was observed between the familial and nonfamilial subgroups of ET. Multiple regression analysis revealed relationship between @entity194 and @entity400 severity score. CONCLUSIONS: @entity1 with ET showed widespread areas of @entity194 in both cerebellum and cerebral GM, which supports the current concept of the progressive and diffuse nature of ET. @entity1 with additional head @entity400 may represent a distinct subgroup of ET.
