Male @entity19 have increased thrombotic potential: sex differences in a XXXX model of @entity49 .

@entity32 @entity39 @entity19 @entity5 @entity635 @entity49 @entity715
INTRODUCTION: Our objectives were to characterize sex differences during @entity49 , using the electrolytic inferior vena cava model of the disease. MATERIALS AND METHODS: Male and female C57BL/6 @entity19 (6-8 weeks) underwent @entity715 . Time points included 6 hours, day 2, day 6, and day 14 post surgery, along with surgically na  ve true controls and surgical shams. Analyses included @entity715 weight, vein wall morphometrics, vein wall protein and gene expression for P-selectin, @entity635 , and @entity5 @entity39 factor-a; hematology, soluble P-selectin, and plasma microparticle tissue factor activity assays. RESULTS: Male venous thrombi were significantly larger than females at days 2 (13.1    1.0 vs. 6.8    0.5   10(-3) grams, p < 0.01), 6 (10.4    0.8 vs. 5.4    0.5   10(-3) grams, p < 0.01) and 14 (6.3    0.5 vs. 4.1    0.3   10(-3) grams, p < 0.01). Both male and female @entity19 exhibited significantly increased vein wall P-selectin at 6 hours, vs. true controls (p < 0.05). Males had increased vein wall @entity635 , versus females, at 6 hours (180.926    24.596 vs. 60.417    10.478 pg/mL, p < 0.05) and day 6 (76.966    13.081 vs. 33.834    4.198 pg/mL, p < 0.01). Males showed decreased @entity5 @entity39 factor-a expression (-66 %) at 6 hours. Females had increased @entity5 @entity39 factor-a expression at 6 hours (+541%) and day 6 (+539%). Both sexes demonstrated decreased peripheral platelets at 6 hours (p < 0.05), coinciding with thrombogenesis. Plasma P-selectin increased in both sexes, versus controls, through day 6 (p < 0.05). CONCLUSIONS: Males had significantly larger venous thrombi than females. Sex differences in vascular anatomy and response to @entity32 may influence @entity715 formation in our @entity19 @entity715 model.
