Lower estimated GFR and higher XXXX are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts.

@entity1 @entity740 @entity633 @entity810 @entity1011 @entity454
Both a low estimated glomerular filtration rate (eGFR) and @entity633 are known risk factors for @entity454 ( @entity454 ). To determine their joint contribution to @entity454 and other kidney outcomes, we performed a meta-analysis of nine general population cohorts with 845,125 @entity1 and an additional eight cohorts with 173,892 @entity1 , the latter selected because of their high risk for @entity740 ( @entity740 ). In the general population, the risk for @entity454 was unrelated to eGFR at values between 75 and 105 ml/min per 1.73 m(2) but increased exponentially at lower levels. Hazard ratios for eGFRs averaging 60, 45, and 15 were 4, 29, and 454, respectively, compared with an eGFR of 95, after adjustment for @entity633 and cardiovascular risk factors. Log @entity633 was linearly associated with log @entity454 risk without thresholds. Adjusted hazard ratios at albumin-to- @entity1011 ratios of 30, 300, and 1000 mg/g were 5, 13, and 28, respectively, compared with an albumin-to- @entity1011 ratio of 5. @entity633 and eGFR were associated with @entity454 , without evidence for multiplicative interaction. Similar associations were found for @entity810 and progressive @entity740 . In high-risk cohorts, the findings were generally comparable. Thus, lower eGFR and higher @entity633 are risk factors for @entity454 , @entity810 and progressive @entity740 in both general and high-risk populations, independent of each other and of cardiovascular risk factors.
