Relation between exercise central haemodynamic response and resting cardiac structure and function in young healthy XXXX .

@entity1 @entity122 @entity1062
BACKGROUND: Left ventricular (LV) structure and function are predictors of cardiovascular (CV) morbidity and mortality and are related to resting peripheral haemodynamic load in older adults. The central haemodynamic response to exercise may reveal associations with LV structure and function not detected by traditional peripheral (brachial) measures in a younger population. PURPOSE: To examine correlations between acute exercise-induced changes in central artery stiffness and wave reflections and measures of resting LV structure and function. METHODS: Sixteen healthy @entity1 (age 26      6  year; BMI 25  3      2  7  kg  m(-2) ) had measures of central haemodynamic load measured before/after a 30-s @entity1062 ( @entity1062 ). Common carotid artery stiffness and reflected wave intensity were assessed via wave intensity analysis as a regional pulse wave velocity ( @entity122 ) and negative area (NA), respectively. Resting LV structure (LV mass) and function [midwall fractional shortening (mFS)] were assessed using M-mode echocardiography in the parasternal short-axis view. RESULTS: There was a significant association between mFS and @entity1062 -mediated change in carotid systolic BP (r  =  -0  57, P  =  0  011), logNA (r  =  -0  58, P  =  0  009) and @entity122 (r  =  -0  44, P  =  0  045). There were no significant associations between resting mFS and changes in brachial systolic BP (r  =  -0  26, P>0  05). There were no associations between resting LV mass and changes in any haemodynamic variable (P>0  05). CONCLUSION: Exercise-induced increases in central haemodynamic load reveal associations with lower resting LV function in young healthy @entity1 undetected by traditional peripheral haemodynamics.
