[Treatment of Level 2 XXXX by Diagnosis and Treatment Program of Integrative Medicine: a Multi-centre, Randomized Controlled Trial].

@entity1 @entity101 @entity918 @entity594 @entity551
OBJECTIVE: To explore the therapeutic effect of diagnosis and treatment program of integrative medicine (IM) on level 2 @entity101 in the young and middle-aged @entity1 and their ambulatory blood pressure. METHODS: A randomized, placebo parallel and controlled, multi-center clinical trial was performed. Totally 199 young and middle-aged level 2 @entity101 @entity1 were randomly assigned to the treatment group (99 cases) and the control group (100 cases). All received combined @entity551 treatment program by taking @entity594 Sustained Release Tablet and @entity918 as basic drugs. @entity1 in the treatment group additionally took Western medicine (WM) combined Jiangyabao serial drugs (0.31 g per tablet, 2 tablets each time, twice daily), while those in the control group additionally took WM combined simulative agents of Jiangyabao serial drugs (0.31 g per tablet, 2 tablets each time, twice daily). The treatment course was 8 weeks for all, and 24-week follow-ups performed. 24 h ambulatory blood pressure and casual blood pressure, and their efficacies were compared between the two groups, and safety assessed as well. RESULTS: Compared with before treatment in the same group, daytime and night casual blood pressure, as well as 24 h ambulatory blood pressure were all obviously improved in the two groups (P < 0.01). Average @entity551 at night decreased more in the treatment group than in the control group with statistical difference (P < 0.05). There was no statistical difference in total efficacies of daytime casual blood pressure or ambulatory blood pressure (P > 0.05). CONCLUSION: Jiangyabao serial drugs combined WM in treating young and middle-aged level 2 @entity101 @entity1 showed obvious effect in improving night blood pressure, especially for night diastolic blood pressure.
