Protection against @entity2759 with XXXX -induced hypoglycemia.

@entity63 @entity95 @entity2759 @entity880 @entity451 @entity8446 @entity413
The effect of @entity8446 -induced reduction in blood @entity413 to 65 +/- 20 mg/dl (mean +/- standard deviation) on recovery of electrophysiological function and extracellular @entity880 concentration was studied in a @entity95 model of @entity2759 . These results were compared to findings in animals with @entity2759 that either were fasted overnight (fasted group: blood @entity413 97 +/- 26 mg/dl) or had no pretreatment (control group: blood @entity413 172 +/- 65 mg/dl). The aorta was occluded until the postsynaptic waves of the spinal somatosensory evoked potentials (SSEP's) had been absent for 20 minutes, a period of @entity63 that produces @entity451 in 100% of untreated @entity95 . The total aortic occlusion time was not significantly different in the three groups. Recovery of the SSEP's was significantly better in the @entity8446 -treated animals than in the fasted or control animals. The N3 wave of the SSEP's, which has been found to correlate best with neurological recovery, returned to 65% +/- 48% of the preischemia amplitude in the @entity8446 -treated animals, compared to 40% +/- 34% in the fasted group and 26% +/- 24% in the control animals. Extracellular @entity880 concentration in the spinal cord increased immediately after occlusion of the aorta, reached a plateau as the postsynaptic waves disappeared from the SSEP's, and then increased a second time during the first 15 minutes of reperfusion. The peak @entity880 concentration during @entity63 and during reperfusion correlated with the preischemia @entity413 concentration (r = 0.60336 and r = 0.76930, respectively). @entity880 concentration in the spinal cord was higher during @entity63 and throughout the first 2 hours of reperfusion in the control and fasted animals than in the @entity8446 -treated animals. During the 2nd hour of reperfusion, @entity880 concentration was significantly higher in the control animals than in the fasted animals. Reduction in blood @entity413 with @entity8446 improves recovery of electrophysiological function after @entity2759 , probably because of reduced @entity880 production, especially during the early reperfusion period.
