Keep the brain cool--endovascular cooling in @entity1 with severe XXXX : a case series study.

@entity1 @entity131 @entity428 @entity772 @entity221
BACKGROUND: As brain temperature is reported to be extensively higher than core body temperature in @entity131 ( @entity131 ) @entity1 , posttraumatic @entity221 is of particular relevance in the injured brain. OBJECTIVE: To study the influence of prophylactic normothermia on brain temperature and the temperature gradient between brain and core body in @entity1 with severe @entity131 using an intravascular cooling system and to assess the relationship between brain temperature and @entity428 ( @entity428 ) under endovascular temperature control. METHODS: Prospective case series study conducted in the neurologic intensive care unit of a tertiary care university hospital. Seven @entity1 with severe @entity131 with a Glasgow @entity772 Scale score of 8 or less were consecutively enrolled. Prophylactic normothermia, defined as a target temperature of 36.5  C, was maintained using an intravascular cooling system. Simultaneous measurements of brain and urinary bladder temperature and @entity428 were taken over a 72-hour period. RESULTS: The mean bladder temperature in normothermic @entity1 was 36.3    0.4  C, and the mean brain temperature was determined as 36.4    0.5  C. The mean temperature difference between brain and bladder was 0.1  C. We found a significant direct correlation between brain and bladder temperature (r = 0.95). In 52.4% of all measurements, brain temperature was higher than core body temperature. The mean @entity428 was 18    8 mm Hg. CONCLUSION: Intravascular temperature management stabilizes both brain and body core temperature; prophylactic normothermia reduces the otherwise extreme increase of intracerebral temperature in @entity1 with severe @entity131 . The intravascular cooling management proved to be an efficacious and feasible method to control brain temperature and to avoid @entity221 in the injured brain. We could not find a statistically significant correlation between brain temperature and @entity428 .
