Hopelessness and suicidal ideation in outpatients with XXXX : prevalence and impact on treatment outcome.

@entity1 @entity308 @entity5080 @entity13217 @entity204
@entity308 and hopelessness are risk factors for suicide. The purpose of this study was to examine the extent of suicidal ideation and hopelessness in outpatients with @entity13217 ( @entity13217 ) and to study the impact of suicidal ideation and hopelessness on treatment with @entity5080 (NT). The degree of suicidal ideation and hopelessness was assessed during the screen visit with the use of items #3 and #30 of the Hamilton @entity308 Rating Scale (HAM-D) in 89 @entity1 with @entity13217 who entered a 6-week open trial of NT. Forty of these @entity1 also completed the Beck Hopelessness Index (BHI) during the screen visit. In separate logistic regressions, the scores from the BHI and the two HAM-D items were then tested as predictors of clinical response to the 6-week trial with NT, controlling for the severity of @entity308 . More than half of @entity1 reported thoughts or wishes of @entity204 to self and significant hopelessness. A greater degree of hopelessness before treatment in completers, reflected by the score on the HAM-D item #30, predicted response to NT. More than half of @entity1 with prominent hopelessness who completed the trial responded. @entity1 with @entity13217 are more likely than not to report prominent suicidal ideation and hopelessness. Furthermore, a full 6-week trial of NT, a relatively noradrenergic tricyclic antidepressant, may be particularly useful in @entity1 who have failed to respond to several antidepressants and also report significant hopelessness.
