Association of XXXX With 24-Hour Urinary Catecholamines in Individuals With Untreated High Blood Pressure.

@entity1 @entity286 @entity308 @entity101 @entity167 @entity148 @entity1063 @entity65
OBJECTIVE: @entity308 and @entity148 are considered risk factors for @entity65 ( @entity65 ). The explanatory mechanisms, however, are still to be characterized. One proposed pathophysiological pathway is dysregulation of the autonomic nervous system, including heightened sympathetic nervous system activity. This study examined the relationship between symptoms of @entity308 , @entity148 , and sympathetic nervous system activity in individuals with @entity101 . METHODS: A total of 140 @entity1 with @entity101 (55% white, 38.5% female, mean [standard deviation] age = 45.5 [8.55] years) collected urine over a 24-hour period on 3 separate occasions. Urine samples were assayed for mean 24-hour epinephrine (EPI24) and @entity1063 excretion. @entity308 symptoms were assessed using the Beck @entity308 Inventory, with @entity148 symptoms assessed using the Spielberger State-Trait @entity148 Inventory. RESULTS: @entity308 and @entity148 scores were intercorrelated (r = 0.76, p < .001). EPI24 was positively correlated with @entity148 (r = 0.20, p = .02) but not @entity308 (r = 0.02, p = .77), whereas 24-hour urinary @entity1063 excretion was not correlated with @entity148 (r = 0.10, p = .21) or with @entity308 (r = 0.07, p = .39). Regression models, accounting for sex, age, body mass index, race, mean systolic ambulatory blood pressure, @entity286 use, @entity167 use, physical activity, and sleep efficiency confirmed that @entity148 was associated with EPI24 excretion (p = .023) and that depressive symptoms were not (p = .54). CONCLUSIONS: @entity148 was associated with heightened sympathoadrenal activity, suggesting a biological pathway through which @entity148 could increase @entity65 risk. @entity148 and @entity308 may confer increased @entity65 risk via different mechanisms.
