[Clinical and cytogenetic studies of XXXX with isolated trisomy 11].

@entity1 @entity2590 @entity1050 @entity3052 @entity828 @entity1778 @entity1583
OBJECTIVE: To evaluate the association between isolated trisomy 11 and the clinical, hematological, immunological, prognostic aspects in @entity1583 . METHODS: Bone marrow cell cytogenetic analysis was performed by direct method and/or 24 h culture method. RHG banding was used for karyotype analysis. Immunophenotype analysis was carried out by flow cytometry. Ten @entity1 with @entity3052 ( @entity3052 ) were treated with HA regimen chemotherapy and followed up. RESULTS: The isolated trisomy 11 was found in 11 of 1 * ! 763 @entity1583 cases (0.6%). The diagnoses included 10 @entity3052 (6 M(2), 2 M(5), 1 M(1), 1 M(4)), and 1 @entity2590 syndromes. Ten of them have no @entity828 . The immunophenotypical analysis of @entity1778 cells showed positive for @entity1050 (13), @entity1050 (33) and @entity1050 (34) in 5 cases. Follow-up data were available in 10 cases. The complete remission rate was 40% with a median survival of 10 months. CONCLUSION: The isolated trisomy 11 was mainly seen in @entity3052 , especially in M(2) subtype. Their prognosis was poor.
