Respiratory function in recent XXXX with special reference to small airways.

@entity1 @entity1568 @entity66 @entity26 @entity409 @entity1565 @entity1030 @entity370 @entity10070
This study was designed to evaluate airway dysfunction in relation to duration of disease in @entity1 with @entity10070 for less than two years. Twenty four subjects with @entity66 were compared with nine subjects with disease of more than two years' duration. They underwent lung function testing (lung volumes, lung transfer factor for CO and pulmonary mechanics). Small airway function was assessed using frequency dependence of compliance, closing volume, @entity1568 single breath test and flow-volume curves breathing air and helium- @entity26 mixture. @entity409 was seen in @entity10070 even in some @entity1 with @entity66 and it became more evident in disease of longer duration. The results suggest small airway involvement. The frequency of airway dysfunction is difficult to evaluate, varying from estimates of 0% using flow-volume curves to 79% with frequency dependence of compliance. This apparent discrepancy could be explained by the consequences of parenchymal involvement leading to inhomogeneities in distribution of compliance, and of elastic lung recoil. We conclude that @entity1 with recent @entity370 are probably affected by @entity1565 , but an increase in elastic recoil often conceals its consequences. The @entity1030 may not be apparent using conventional function tests and published predicted values.
