Increased apoptosis in remote non-infarcted XXXX in multivessel @entity301 .

@entity1 @entity296 @entity712 @entity522 @entity589 @entity301 @entity66 @entity63 @entity1416 @entity519 @entity1188 @entity1562 @entity299 @entity583 @entity204
BACKGROUND: Multivessel @entity301 after @entity583 is a major risk factor for unfavorable @entity299 and @entity204 due to pump failure, but underlying pathophysiologic mechanisms are still uncompletely established. Post- @entity1188 @entity296 has been recently implicated as a cause of ongoing cell loss leading to @entity712 . Our aim was to assess the role of post- @entity1188 @entity296 and pro-apoptotic factor expression in the non-infarcted remote @entity1562 of subjects with multivessel @entity301 . METHODS: Twenty-one males dying after recent @entity583 with permanent occlusion of the @entity1188 were selected at autopsy. Apoptosis was assessed at viable myocardial regions remote from @entity1188 by co-staining for in situ end-labeling of DNA fragmentation and cleaved @entity522 . Expression of pro-apoptotic factor @entity589 and @entity519 -induced factor-1alpha was evaluated by immunohistochemistry. RESULTS: Subjects with multivessel disease (N=11) showed a significantly two-fold higher @entity296 in comparison to subjects with @entity66 (N=10) (0.9% vs. 0.5%, p=0.013). Similarly, myocardial @entity589 expression was increased in @entity1 with multivessel disease (3.0% vs. 1.4%, p=0.029). Stratification for the number of diseased coronary vessels confirmed the association between extent of @entity301 and apoptotic rates (p=0.022). Even in subjects dying over 30 days after @entity1188 remained predictive of enhanced myocardiocyte apoptosis at remote regions (p=0.033). CONCLUSIONS: Post- @entity1188 @entity296 and @entity589 expression in remote left ventricular regions are significantly increased in male @entity1 with multivessel @entity301 in comparison to those with isolated @entity1416 . These findings suggest that apoptotic cell loss in the viable non-infarcted @entity1562 , possibly due ongoing @entity63 , may play a relevant role in the unfavorable clinical course typical of multivessel disease after @entity583 .
