[Association study between XXXX and @entity50802 functional polymorphisms in the @entity3840 gene and risk of @entity1468 ].

@entity1 @entity50802 @entity1468 @entity3840 @entity17530
OBJECTIVE: To investigate the relationship between two polymorphisms immediately upstream of the @entity3840 ( @entity3840 ) gene and @entity1468 in a South West Han Chinese population. METHODS: Blood samples from 205 @entity1 with @entity1468 and 276 normal pregnant @entity1 as controls from Han Chinese in Chengdu area were analyzed by polymerase chain reaction-restriction fragment length polymorphisms. RESULTS: G and A allele frequencies for @entity50802 site were 48.54% and 51.46% in the @entity1 group, respectively, and 40.40% and 59.60% in the control group, respectively. G and C allele frequencies for @entity17530 site were 94.15% and 5.85% in the case group, respectively, and 94.38% and 5.62% in the control group, respectively. The AA genotype and variant A allelic frequencies of the @entity50802 SNP were significantly lower in @entity1 with @entity1468 than in the control group (P<0.05), and the odds ratio for the risk of @entity1468 was 0.665 (95% CI: 0.444-0.982) in @entity1 homozygous for the variant @entity3840 A allele ( x2=4.233, P=0.047). The genotype and allele frequencies of the @entity17530 polymorphism in @entity1 with @entity1468 and controls showed no significant differences (P>0.05). Additional subgroup analyses (mild vs severe @entity1468 ) of the two polymorphisms failed to reveal significant correlation for either genotypic or allelic frequencies. Furthermore, there was no significant association between the polymorphisms and blood pressure levels in the @entity1 or control groups. CONCLUSION: @entity3840 -1195A homozygosity is associated with a decreased risk for @entity1468 in a South West Han Chinese population. On the other hand, the @entity17530 polymorphism has no effect.
