Value of micro-CT for monitoring spinal microvascular changes after chronic XXXX .

@entity6098 @entity2806 @entity35 @entity16 @entity51 @entity1745 @entity1566
@entity16 can occur after compression of the spinal cord. It is widely accepted that @entity1745 leads to @entity2806 and ultimately @entity51 due to a narrowed spinal canal. Therefore, an in-depth understanding of the pathogenesis of @entity1566 is required to help develop effective clinical interventions. In the present study, we propose a new method of quantitative 3D micro-CT to observe microvascular events in a chronic @entity1745 @entity35 model. A total of 36 @entity35 were divided into two groups: sham control group (n = 12) and compressive @entity1566 group (n = 24). @entity35 were scarified at four weeks after surgery. In each group, @entity6098 micro-vessel immunohistochemical staining was performed in half of the animals, while micro-CT scanning was performed in the other half. Microvessel density (MVD) was measured after immunohistochemical staining, while the vascular index (VI) was measured in 3D micro-CT. In comparison with sham control, abnormal somatosensory evoked potentials (SEP) can be seen in all 24 cases of the compression group, and VI shows the amount of microvessels reduced consistently and significantly (p < 0.01). A significant correlation is also found between MVD and VI (r = 0.95, p < 0.01). These data suggest that quantitative 3D micro-CT is a sensitive and promising tool for investigating microvascular changes during chronic compressive @entity1566 .
