Effects of sodium arsenite exposure on development and behavior in the XXXX .

@entity1 @entity4250 @entity2915 @entity4207 @entity35 @entity3494
@entity3494 is an environmental contaminant found in soil, water and air in some zones of the world. It has been widely studied for its effects as a @entity1 carcinogenic agent, but few studies have dealt with neurobehavioral effects. In addition, studies of @entity3494 effects on development have only addressed its effects on embryotoxicity and teratogenicity after a single oral, gavage or intraperitoneal exposure. Among the behavioral alterations reported after intoxication with @entity3494 are both increased and decreased locomotor activity and @entity4207 in a delayed alternation task [Toxicol. Lett. 54 (1990) 345; Bull. Environ. Contam. Toxicol. 50 (1993) 100; Brain Res. Bull. 55 (2001) 301]. To further characterize developmental and behavioral alterations induced by @entity3494 exposure, @entity35 were exposed to @entity4250 (36.70 mg @entity3494 /l in drinking water) from gestation day 15 (GD 15) or postnatal day 1 (PND 1), until approximately 4 months old. The pregnant or lactating dams received either the @entity3494 solution or regular drinking water and once pups were weaned, they continued receiving the same solution as drinking water. Animals exposed from GD 15 showed @entity2915 and both exposed groups showed increased number of errors in a delayed alternation task in comparison to the control group. Total @entity3494 (TA) content in brain was similar for both exposed groups and significantly different from the control group. These results indicate that @entity35 exposed to @entity3494 during development present deficits in spontaneous locomotor activity and alterations in a spatial learning task.
