Angiogenesis in XXXX . An acute or chronic process?

@entity1 @entity353 @entity7 @entity117 @entity6758 @entity583
BACKGROUND: In the acute phase of @entity583 (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of @entity7 ( @entity7 , possibly marking angiogenesis) in the first 24h post thrombolysis compared to chronic MI @entity1 (defined as MI>3 months previously). METHODS: We recruited 15 @entity1 (nine male, mean age 59+/-SD 10 years) with first-presentation acute MI, who were given 1.5 million U streptokinase over 1h and @entity117 300mg orally as standard treatment. Plasma samples were taken prior to the start of thrombolysis, followed every 15 min for 1h, at 3h and finally at 24h post-thrombolysis. Baseline levels of measured indices in the acute MI @entity1 were compared to two control groups: (i) 26 chronic MI @entity1 (18 male, mean age 59.9+/-7.0 years); and (ii) 26 apparently healthy controls (17 male, mean age 59.6+/-14.1 years). Plasma @entity7 and the soluble form of its receptor @entity6758 (sFlt-1) were measured by ELISA. RESULTS: Plasma levels of @entity7 were significantly higher in @entity1 with a history of chronic MI compared to @entity1 with acute MI (P=0.007) and healthy controls (P=0.002) with similar levels between acute MI @entity1 and healthy controls (P=0.755). Levels of sFlt-1 in the @entity353 groups were lower compared to healthy controls. In the first 24h post-thrombolysis in the acute MI group, levels of sFlt-1 changed significantly (P=0.039), but there was no change in levels of @entity7 (P=0.207). CONCLUSION: In the first 24h of acute MI, significant changes in levels of @entity7 receptor sFlt-1, but not @entity7 , are seen. Plasma @entity7 and sFlt-1 levels are markedly changed in chronic MI @entity1 , suggesting that the activation of angiogenesis in MI @entity1 may be a delayed response.
