T-type XXXX channels in neuropathic pain.

@entity239 @entity6 @entity16 @entity74 @entity158 @entity460
UNASSIGNED: @entity158 is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, @entity16 are retrieved with identified etiologies (chemotherapies, @entity6 , surgeries   ) and also more diffuse syndromes such as @entity239 . More broadly, @entity158 is one of the first consequences of most @entity74 . Despite its importance for the quality of life, current @entity158 management is limited to drugs that are either old or with a limited efficacy or that possess a bad risk benefit ratio. As no new pharmacological concept has led to new analgesics in the last decades, the discovery of new medications is needed, and to this aim, the identification of new druggable targets in @entity158 transmission is a first step. Therefore, studies of ion channels in @entity158 pathways are extremely active. This is particularly true with ion channels in peripheral sensory neurons in dorsal root ganglia known how to express unique sets of these channels. Moreover, both spinal and supraspinal levels are clearly important in @entity158 modulation. Among these ion channels, we and others revealed the important role of low voltage-gated @entity460 channels in cellular excitability in different steps of the @entity158 pathways. These channels, by being activated nearby resting membrane potential, have biophysical characteristics suited to facilitate action potential generation and rhythmicity. In this review, we will present the current knowledge on the role of these channels in the perception and modulation of @entity158 .
