Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring XXXX with normal polysomnographic findings.

@entity1 @entity15203 @entity28 @entity20202 @entity413
BACKGROUND: @entity1 who snore but do not have gas exchange abnormalities or alterations of sleep architecture have @entity20202 ( @entity20202 ). Since increasing evidence suggest that @entity20202 may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in @entity20202 @entity1 . METHODS: @entity1 (aged 4-9 years) with and without habitual snoring and a normal @entity15203 were designated as either @entity20202 or controls. Whole genome expression profiles of PBL and metabolic parameters in 30 @entity1 with @entity20202 and 30 age-, gender-, ethnicity-, and BMI-matched controls were compared. Pathway-focused gene network analysis of the PBL transcriptome was performed. Metabolic parameters were measured in an independent follow-up cohort of 98 @entity1 (64 @entity20202 and 34 controls) to evaluate the computationally derived findings. RESULTS: @entity20202 was not associated with a distinct transcriptional signature in PBL. Exploratory functional network analysis of enriched gene sets identified a number of putative pathways-including those mapping to insulin signaling, adipocyte differentiation, and @entity28 -with significant alterations in @entity413 metabolism and insulin sensitivity emerging in the follow-up cohort of @entity1 with @entity20202 , but no differences in lipid profiles. CONCLUSIONS: @entity20202 @entity1 do not exhibit global perturbations in their PBL transcriptional response, suggesting that current normative @entity15203 criteria are overall valid. However, subtle differences in functionally coherent pathways involved in glycemic homeostasis were detected and confirmed in a larger independent pediatric cohort indicating that @entity20202 may carry increased risk for end-organ morbidity in susceptible @entity1 .
