Intratympanic methylprednisolone in refractory sudden @entity393 : a 27- XXXX case series with univariate and multivariate analysis.

@entity1 @entity134 @entity1274 @entity230 @entity393
BACKGROUND: Treatment of sudden @entity393 is a significant matter of discussion. Lack of knowledge of the natural history of the disease and the use of different success criteria are 2 of the main reasons why it is difficult to critically evaluate the data available in the literature. To date, no therapy has proved effective according to the evidence criteria. However, there has been a trend toward the use of @entity230 in recent years. The management of @entity1 who fail to respond to standard therapy is even more complex; in these cases, intratympanic @entity230 have been proposed as a valuable solution. METHODS: Twenty-seven @entity1 unresponsive to traditional systemic therapy were treated with intratympanic @entity230 . RESULTS: The mean pure-tone average before intratympanic treatment was 79.9 +/- 21.4 SD dB; at Day 30, after local @entity134 administration, the mean pure-tone average was 60.6 +/- 24.9 SD dB. According to our criteria, 15 (55%) of 27 @entity1 presented a "useful" improvement in the hearing status. No serious complications have been observed. CONCLUSION: Local application is confirmed as easy to perform and is associated with negligible complications. Our experience, although retrospective, seems to confirm the usefulness (at least in 50% of @entity1 ) of local @entity230 administration in cases of refractory sudden @entity1274 . Our encouraging data strongly call for further and serious evaluation through randomized studies.
