Prophylactic @entity6101 in XXXX bite wounds.

@entity1 @entity235 @entity6101 @entity281 @entity130
This prospective, double-blind, placebo-controlled study was undertaken to determine the value of prophylactic @entity6101 in @entity235 bites. Adult @entity1 with uninfected full-thickness wounds presenting within 24 hours of @entity130 were considered. Management consisted of cleansing, irrigation, debridement, and closure as indicated; no topical antibiotics were applied. @entity1 were randomly assigned to receive @entity6101 500 mg QID x 5 days or identically appearing placebo. Home wound care was standardized an @entity1 were observed at least every 2 days. Clinical assessment of infection was confirmed microbiologically. Sixty-three @entity1 were admitted and 46 completed the study. @entity6101 (22) and placebo (24) groups were identical in sex, age, number of wounds per @entity1 , wound location and type, number of open and closed wounds, delay to presentation, length of follow-up observation, medication compliance, and adequacy of @entity1 wound care. Two @entity281 of the hand occurred in @entity1 receiving @entity6101 ; no @entity281 were seen among placebo-treated @entity1 (P = NS). Prophylactic @entity6101 was not associated with improved outcome. We do not advise the use of prophylactic antibiotics in @entity235 bite injuries treated within 24 hours of accident.
