Long-term accelerated forgetting of verbal and non-verbal information in XXXX .

@entity1 @entity410 @entity131 @entity75 @entity1315 @entity302 @entity2414
INTRODUCTION: We investigated whether pre-surgical @entity1 with @entity1315 ( @entity1315 ) forget verbal and non-verbal material faster than healthy controls over retention intervals of an hour and 6 weeks, and whether any observed @entity2414 was associated with structural changes to the hippocampus and/or @entity410 frequency. METHODS: A mixed factorial design compared the performance of 27 @entity1 with @entity1315 and 22 healthy control @entity1 , matched for IQ, age and gender, on tests of story recall and complex figure recall at three delays: immediate, 1 h and 6 weeks. Performance of the @entity1 and control groups was matched at the immediate delay, which enabled comparisons of forgetting rate over the longer delays. RESULTS: We found that @entity1315 can affect the acquisition and retention of new memories over a relatively short delay of 1h. This deficit was associated with @entity75 , with a material-specific effect that was particularly evident for the verbal task. We also found evidence of accelerated long-term forgetting in both @entity1 groups, for the verbal and non-verbal tasks. It was demonstrated most strongly on the verbal task by the @entity1 with right lateralized @entity131 whose verbal recall was normal at the 1-h delay. Accelerated long-term forgetting was not associated with hippocampal pathology, but was associated with the frequency of @entity302 . DISCUSSION: The findings from the verbal task in particular provide evidence consistent with an extended period of memory consolidation that can be disrupted by both left and right @entity1315 . The material-specific effects at the 1-h delay only, suggest that the initial consolidation of verbal and non-verbal, information depends on the integrity of the left and right hippocampus, respectively.
