Pubertal maturation of the lh stimulatory response to @entity4082 in congenital virilizing XXXX .

@entity1 @entity4082 @entity619 @entity230 @entity652 @entity774
To determine the LH release response to @entity4082 in @entity1 with virilizing @entity774 ( @entity774 ), we examined six @entity1 with glucocorticoid-treated virilizing @entity774 , five @entity1 and one @entity1 , chonological age (CA) 4 years 2 months-15 years 9 months and bone age (BA) range 8-18 years. All the @entity1 but one, were treated with nocturnal @entity619 . Their ages at the onset of treatment ranged from 2 years 6 months to 13 years 8 months. An additional @entity1 (CA = 4 years 3 months and BA = 7-8 years) was studied 10 days after removal of a virilizing @entity652 . @entity4082 (3mg/kg/day) was administered orally in two doses/day for 8 days. Venous blood was collected on days 0, 4, 6 and 8. Two @entity1 were also studied in consecutive years. In three @entity1 no increase was noted over the basal levels of LH, but in the others LH rose during @entity4082 administration. In two @entity1 studied in consecutive years, there was detectable shift of LH release pattern. The basal LH levels and the sum of responses (day 4, 6 and 8) to @entity4082 and particularly their decimal logarithms were statistically significantly correlated with their respective BA. These results confirm that previous prolonged exposure to elevated concentrations of adrenal sex @entity230 , in @entity1 with treated virilizing @entity774 , may induce precocious maturation of the hypothalamic pubertal mechanism of LH secretion. This maturation was closely correlated with the degree of skeletal maturation.
