Plasminogen Activation System in XXXX .

@entity1 @entity2289 @entity10431 @entity5 @entity1456 @entity3 @entity420
BACKGROUND: The purpose of the present study was to determine the extent of expression of proteins that are the elements of the plasminogen activation system, i.e. urokinase plasminogen activator ( @entity10431 ), receptor of @entity10431 ( @entity10431 ), @entity2289 ( @entity2289 ) and @entity1456 (tPA) in the primary site of @entity420 , as well as in lymph node @entity3 , and their correlation with clinical and pathological data. MATERIALS AND METHODS: The study material consisted of archival paraffin blocks from 108 @entity1 with confirmed oncological diagnosis, treated in 2002 and 2003 in the Lower Silesian Oncology Centre in Wroclaw. This material was used for immunohistochemical reactions with antibodies against @entity10431 , @entity10431 , @entity2289 and tPA. The extent of expression was evaluated semi-quantitatively based on the immunoreactive score according to Remmele and Stegner. The obtained results were correlated with clinical and pathological data: stage of the disease (modified Dukes' classification of Astler and Coller), grade of @entity5 , event-free survival and overall survival. RESULTS: It was found that cytoplasmic expression of @entity10431 , @entity10431 , @entity2289 and tPA was higher in cells of @entity5 and @entity3 of perienteric lymph nodes in comparison to normal rectal tissues. Positive correlation was shown between expression of @entity2289 and tPA, @entity10431 and @entity10431 , as well @entity10431 and @entity2289 (r=0.70, r=0.77 and r=0.34, respectively; p<0.05 for all). Additionally, in @entity1 with low and moderate expression of @entity10431 and @entity10431 , the overall survival rate was higher in comparison to @entity1 with high expression of the studied markers. CONCLUSION: The intensity of expression of @entity10431 and @entity10431 might be a prognostic factor of survival time for @entity1 with primary @entity420 .
