XXXX Resistance in @entity13473 Is Overpowered by Coapplication of Pro-oxidants.

@entity1 @entity9413 @entity2379 @entity13473 @entity26 @entity364 @entity237
AIMS: Invasive @entity364 have significantly increased over the past decades in immunocompromised individuals and high-risk @entity1 . @entity2379 ( @entity237 ) exerts a powerful and broad activity against a vast array of fungi and has a remarkably low rate of microbial resistance. However, most isolates of @entity13473 developed an intrinsic resistance against @entity237 , and during this study, we characterized the mode of action of this @entity9413 antifungal drug in more detail in resistant (ATR) and rare susceptible (ATS) clinical isolates of A. terreus. RESULTS: We illustrate that @entity237 treatment changes cellular redox status and promotes the generation of high levels of reactive @entity26 species (ROS) in ATS. In contrast, ATR isolates were able to cope better with @entity237 -induced oxidative stress. INNOVATION: Most importantly, we demonstrate in this study that coapplication of anti- and pro-oxidants significantly affects @entity237 efficacy in an antithetic manner-antioxidants and ROS-scavenging agents increase @entity237 tolerance in susceptible strains, while pro-oxidants render formerly resistant isolates considerably susceptible to the antifungal drug also in vivo in a Galleria animal model. CONCLUSION: Thereby, our study provides novel therapeutic options to treat formerly resistant fungal strains by a combination of @entity237 and pro-oxidant compounds. Antioxid. Redox Signal. 00, 000-000.
