Relationship between insulin response to intravenous XXXX and plasma lipoproteins in healthy men.

@entity72799 @entity455 @entity156 @entity412 @entity413 @entity165
In order to evaluate the influence of serum insulin levels on serum lipoprotein composition, 62 randomly selected healthy males were studied. All of them had a normal @entity413 tolerance. The Insulin Response to a bolus of intravenous @entity413 (0.50 g/kg) was significantly correlated with VLDL- @entity412 (p less than 0.01), @entity72799 (p less than 0.01) and with the "Atherogenic Index" (Formula: see text) (p less than 0.01). Moreover, stratifing the all population in quartiles according to the Insulin Response distribution, the highest quartile had a significant increase in Total and VLDL- @entity165 levels (p less than 0.02), as well as in Total (p less than 0.02), VLDL (p less than 0.02) and LDL (p less than 0.01) @entity412 , in comparison with the lowest quartile. The Atherogenic Index was also significantly elevated in the high Insulin Response group (p less than 0.005). The influence of serum insulin on lipoprotein metabolism was also evaluated by a stepwise multiple regression analysis. Body weight, Insulin Response and Exogenous @entity412 removal were independently correlated with VLDL- @entity412 concentration (r = 0.58, p less than 0.001). VLDL @entity165 concentration and fasting serum insulin levels were inversely correlated with HDL- @entity165 (r = 0.49, p less than 0.001). In conclusion, in absence of any metabolic derangement, high insulin levels are associated with @entity156 . Insulin might act as a risk factor for @entity455 through its influence on serum lipoproteins.
