Hippocampal-thalamic wiring in medial XXXX : Enhanced connectivity per hippocampal voxel.

@entity1 @entity131 @entity410 @entity3808 @entity1463 @entity1315
OBJECTIVE: Medial @entity1315 ( @entity1315 ) with @entity131 is often accompanied by widespread changes in ipsilateral and contralateral white matter connectivity. Recent studies have proposed that @entity1 may show pathologically enhanced wiring of the limbic circuits. To better address this issue, we specifically probed connection patterns between hippocampus and thalamus and examined their impact on cognitive function. METHODS: A group of 44 @entity1 with @entity1315 (22 with right and 22 with left @entity131 ) and 24 healthy control @entity1 were examined with high-resolution T1 imaging, memory functional magnetic resonance imaging (fMRI) and probabilistic diffusion tractography. Thirty-four @entity1 had further extensive neuropsychological testing. After whole brain segmentation with FreeSurfer, tractography streamline samples were drawn with hippocampus as the seed and thalamus as the target region. Two tractography strategies were applied: The first targeted the anatomic thalamic volume segmented in FreeSurfer and the second a functional region of interest in the  mediodorsal thalamus derived from the activation during delayed recognition memory. RESULTS: We found a pronounced enhancement of connectivity between the @entity3808 hippocampus and the ipsilateral thalamus both in the right and left @entity1315 as compared to healthy control @entity1 . This finding held for both the anatomically and the functionally defined thalamic target. Although differences were apparent in the number of absolute fibers, they were most pronounced when correcting for hippocampal volume. In terms of cognitive function, the number of hippocampal-thalamic connections was negatively correlated with performance in a variety of executive tasks, notably in the Trail Making Test, thus suggesting that the pathologic wiring did not compensate cognitive curtailing. SIGNIFICANCE: We suggest that @entity1315 is accompanied by an abnormal and dysfunctional enhancement of connectivity between the hippocampus and the thalamus, which is maximal on the side of the @entity1463 . This pathologic pattern of limbic wiring might reflect structural remodeling along common pathways of @entity410 propagation.
