Obesity accelerates @entity73 by aggravating XXXX , insulin resistance and @entity409 under @entity172 -deprived conditions.

@entity172 @entity73 @entity409 @entity35 @entity1386 @entity4361 @entity2383
UNASSIGNED: Chronic consumption of a @entity1386 ( @entity1386 ) causes peripheral insulin resistance, brain insulin resistance, brain @entity2383 and @entity73 . @entity172 deprivation has also been found to impair cognition. However, the combined effect of both conditions on the brain is unclear. We hypothesized that @entity172 deprivation causes brain insulin resistance, brain @entity2383 , hippocampal @entity409 and @entity73 , and that consumption of a @entity1386 accelerates these impairments in an @entity172 -deprived condition. Seventy-two female @entity35 were divided into sham (S) and ovariectomized (O) groups. @entity35 in each group were further divided into two subgroups to be fed with either a @entity4361 ( @entity4361 ) or @entity1386 for 4, 8 and 12weeks. At the end of each period, the Morris water maze test was carried out, after which the blood and brain were collected for metabolic and brain function analysis. Obesity, peripheral insulin resistance, increased brain oxidative stress and hippocampal @entity409 were observed at the eighth week in the NDO, HFS and HFO @entity35 . However, these impairments were worse in the HFO @entity35 . Interestingly, brain insulin resistance, brain @entity2383 and @entity73 developed earlier (week eight) in the HFO @entity35 , whereas these conditions were observed later at week 12 in the NDO and HFS @entity35 . Either @entity172 deprivation or @entity1386 appears to cause peripheral insulin resistance, increased brain oxidative stress, hippocampal @entity409 , brain @entity2383 and brain insulin resistance, which together can lead to @entity73 . A @entity1386 accelerates and aggravates these deleterious effects under @entity172 -deprived conditions.
