Failure of a single dose of @entity11796 to induce uterine infertility in postnatally treated XXXX .

@entity742 @entity1420 @entity11796 @entity19 @entity7828 @entity3443 @entity1478 @entity1869 @entity468
UNASSIGNED: In @entity19 and @entity742 , neonatal administration of @entity1420 or @entity7828 inhibited development of uterine glands. The aims of the present study were (1) to describe uterine gland development on postnatal Days 6 to 8 and (2) to evaluate the effects of a single postnatal administration of a progestin on reproduction and adult uterine glands morphology and function in @entity468 . Necropsy was performed on three 1-week-old female @entity468 which had died unrelated to this study. Ten female kittens were randomly assigned within the first 24  hours of birth to: @entity11796 10  mg/animal subcutaneously ( @entity3443 ; n  =  6) or placebo (PLC; n  =  4) and followed up until puberty when they were mated. Twenty-four days after the end of estrus, ovulation and pregnancy were diagnosed by serum @entity1420 measurement and ultrasonography, respectively. Then, all the @entity468 were ovariohysterectomized. After necropsy or surgery, the excised organs were histologically evaluated. Seven queens ovulated (4 of 6 @entity3443 and 3 of 4 PLC; P  >  0.1) and were pregnant (P  >  0.1). Four @entity3443 @entity468 presented @entity1869 and one of them developed a pyometra. The 1-week-old females presented uterine glands in the stage of budding and incipient penetration of the glandular epithelium into the underlying stroma. The @entity3443 -treated queens revealed that the area occupied by uterine glands per square-micrometer (0.55      0.2 vs. 0.49      0.2; P  >  0.1) and the height of the glandular epithelium ( m; 24.5      6.7 vs. 24.4      7.2; P  >  0.1) did not differ from those of the PLC group. Neither significant gross nor microscopical differences were also found for ovaries (P  >  0.1). It is concluded that 1-week-old kittens had an incipient stage of uterine gland development and that a single postnatal supraphysiological dose of @entity3443 did not alter uterine adenogenesis in this species. Furthermore, this treatment seemed to predispose to @entity1478 without prevention of fertility.
