MicroRNA 26a Prolongs Skin Allograft Survival and Promotes Regulatory T Cells Expansion in XXXX .

@entity19 @entity47695 @entity1618 @entity3783 @entity777 @entity3 @entity3744 @entity636
UNASSIGNED: MicroRNA 26a ( @entity47695 ) has been reported to play functions in cellular differentiation, cell growth, cell apoptosis and @entity3 . However, the role of @entity47695 in transplant rejection has never been investigated. Full-thickness skin grafts 1 to 2 cm in diameter were obtained from the tail-skin CBA/J donor @entity19 and transplanted onto the back of wild-type C57BL/6 recipient @entity19 . Vectors encoding pre- @entity47695 (LV-26a) and an empty lentiviral vector (LV-Con) delivered approximately 2 * 10(7) transforming units of recombinant lentivirus were injected to @entity19 once through the tail vein. @entity47695 overexpression results in prolonged skin allograft survival (MST = 9.5 days in LV-Con @entity19 ; MST = 22 days in LV-26a @entity19 . P < 0.01) and promoted regulatory T cells (Tregs) expansion. The prolonged skin allograft survival induced by LV-26a was abrogated by depletion of Tregs with anti- @entity3783 antibodies. @entity47695 significantly promoted @entity1618 expression and suppressed the expression of @entity777 , @entity636 and IFN-y. Furthermore, @entity777 overexpression led to complete suppression of the @entity47695 -induced upregulation of @entity3744 . The prolonged allograft survival induced by LV- @entity47695 was also completely abrogated by @entity777 overexpression. In conclusion, @entity47695 prolongs skin allograft survival and promotes Tregs expansion in part through inhibition of @entity777 expression. This article is protected by copyright. All rights reserved.
