Pattern of recurrent disease in major XXXX .

@entity1 @entity66 @entity5 @entity2347 @entity204
UNASSIGNED: This study aims to evaluate the long-term outcome of major @entity2347 ( @entity2347 ). This is a retrospective review of 54 cases of @entity2347 during a 35-year period from 1974 to 2009 at the Helsinki University Central Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. All @entity1 had a minimum follow-up time of 5  years or until @entity204 . Most of the @entity5 occurred in the parotid gland (n   =   30, 56  %) followed by submandibular gland (n   =   22, 41  %) and sublingual gland (n   =   2, 4  %). Fifty-two @entity1 (96  %) were treated with curative intent. All of these @entity1 except one were primarily treated with surgery, and 29 @entity1 (54  %) also received postoperative radiotherapy for their primary @entity5 . Two @entity1 (4  %) received palliative radiotherapy. For those treated with curative intent, 32 @entity1 (62  %) had disease recurrence. Twenty-four @entity1 (75  %) had their first disease recurrence within 5  years and eight @entity1 (25  %) later than 5  years. The difference in the length of recurrence-free time interval (<5 vs. >5  years) had a significant impact on 5-year overall survival (OS) and @entity66 ( @entity66 ). The OS, @entity66 and disease-free survival (DFS) across stages I-IV varied between 46-100, 50-100 and 46-100  %, respectively. Age over 45  years, T stage, and presence of neck metastases had a significant negative prognostic effect. More than half of the @entity1 had recurrent disease. An extended follow-up for these @entity1 seems feasible as most of the distant metastases were detected within a 10-year period.
