[Endoscopic endonasal transsphenoidal approach for XXXX -producing pituitary adenomas. Preliminary results].

@entity1 @entity41 @entity442 @entity2124 @entity5173 @entity2012 @entity652
BACKGROUND: An endoscopic endonasal transsphenoidal approach is reported as less invasive, allowing an earlier discharge. Published series have never focused on its use in acromegalic @entity1 . OBJECTIVE: To assess the effectiveness of an endoscopic endonasal transsphenoidal approach in the management of @entity2124 -secreting @entity652 . @entity1 AND METHODS: Nineteen consecutively operated @entity1 were assessed with a prospective follow-up of one year. RESULTS: Sex ratio was 0.7/1 and gross total removal was obtained in 16 cases (84%), subtotal in three (16%). The only complication was a @entity5173 requiring spinal drainage. The median in-hospital stay was 2.5 days. Sixteen @entity1 experienced clinical improvement (84%) and no changes were observed in three (16%). @entity41 was seen in two cases (11%). @entity2124 levels < 2 ng/dl were seen in 17 cases (89%) and only two @entity1 (11%) had a level >2 ng/dl. @entity442 levels were normalized in 16 cases (84%) and remained elevated in three @entity1 (16%). One @entity1 presented an isolated elevated level of @entity442 . @entity1 with @entity41 and elevated @entity2124 and @entity442 levels underwent complementary radiosurgery. CONCLUSIONS: The endoscopic endonasal transsphenoidal approach seems to be useful in @entity2012 , with a high rate of clinical and biochemical cure among other benefits.
