High-definition optical coherence tomography intrinsic skin ageing assessment in XXXX : a pilot study.

@entity1 @entity1377 @entity2033 @entity2363
UNASSIGNED: Several non-invasive two-dimensional techniques with different lateral resolution and measurable depth range have proved to be useful in assessing and quantifying morphological changes in skin ageing. Among these, only in vivo microscopy techniques permit histometric measurements in vivo. Qualitative and quantitative assessment of chronological (intrinsic) age-related (IAR) morphological changes of epidermis, dermo-epidermal junction (DEJ), @entity1377 ( @entity1377 ), papillary- @entity2363 junction and @entity2363 ( @entity2363 ) have been performed by high-definition optical coherence tomography in real time 3-D. @entity2033 -OCT images were taken at the internal site of the right upper arm. Qualitative @entity2033 -OCT IAR descriptors were reported at skin surface, at epidermal layer, DEJ, @entity1377 and upper @entity2363 . Quantitative evaluation of age-related compaction and backscattered intensity or brightness of different skin layers was performed by using the plugin plot z-axis profile of ImageJ(  ) software permitting intensity assessment of @entity2033 -OCT (DICOM) images (3-D images). Analysis was in blind from all clinical information. Sixty, fair-skinned (Fitzpatrick types I-III) healthy females were analysed retrospectively in this study. The subjects belonged to three age groups: twenty in group I aged 20-39, twenty in group II aged 40-59 and twenty in group III aged 60-79. Only intrinsic ageing in @entity1 has been studied. Significant age-related qualitative and quantitative differences could be noticed. IAR changes in dermal matrix fibers morphology/organisation and in microvasculature were observed. The brightness and compaction of the different skin layers increased significantly with intrinsic skin ageing. The depth of visibility of fibers in @entity2363 increased significantly in the older age group. In conclusion, @entity2033 -OCT allows 3-D in vivo and real time qualitative and quantitative assessment of chronological (intrinsic) age-related morphological skin changes at high resolution from skin surface to a depth of the superficial @entity2363 .
