Restored XXXX in spared myocardium of @entity1188 @entity35 improves ischemic tolerance.

@entity63 @entity1184 @entity2478 @entity23703 @entity1188 @entity4346 @entity880 @entity35 @entity583 @entity1002
@entity583 ( @entity583 )-induced @entity1184 is associated with a decreased @entity2478 , which may negatively affect ischemic tolerance of the spared myocardium. The current study investigated the effects of @entity23703 , a centrally acting sympatholytic, on left ventricular (LV) @entity1184 and @entity2478 in relation to sensitivity to @entity63 in @entity1188 hearts. Infarcted @entity35 were randomized to receive 3 or 6 mg/kg/d of @entity23703 from 1 to 21 days after @entity583 . @entity4346 after @entity583 was indicated by increased ventricular to body weight ratio and was significantly inhibited by @entity23703 . Histologic analysis revealed that @entity583 -induced @entity1184 of the spared myocardium, as indicated by almost double cross-sectional area of Gomori-stained myocytes, was completely prevented by 6 mg/kg/d of @entity23703 . This effect was accompanied by a a restored number of lectin-stained capillaries per tissue area. However, capillary-to-myocyte ratio was similar in all groups. @entity1002 after @entity583 , measured in isolated perfused hearts, was confirmed by decreased LV systolic pressure and +dP/dtmax and was not affected by @entity23703 . Low-flow @entity63 , induced by lowering perfusion pressure from 85 to 15 mm Hg for 30 min, resulted in a further reduction of cardiac perfusion compared with sham @entity35 , which was normalized with 6 mg/kg/d of @entity23703 . Ischemic sensitivity in @entity583 hearts, as reflected by increased maximal coronary flow during reperfusion, was reduced with @entity23703 . This was further supported by substantially lower purines and @entity880 concentrations in the coronary effluent during @entity63 . These results indicate that @entity23703 -induced prevention of @entity1184 may preserve @entity2478 without affecting capillary number, thereby improving ischemic tolerance of the spared myocardium.
