[Antiepileptic drugs and XXXX aggravation.]

@entity1 @entity410 @entity2045 @entity302 @entity2048 @entity3149 @entity3762
UNASSIGNED: Objective. To analyze @entity302 aggravation associated with antiepileptic drugs (AED) in adult @entity1 . Material and methods. We examined 1407 @entity1 aged 18-89 years. Different patterns of @entity410 aggravation were identified in 103 @entity1 . Results. Aggravated @entity410 due the generic substitution were found in 32 @entity1 . First was topiramate (TPM) (n=12), followed by valproates (VPA) (n=8), carbamazepine (CBZ) (n=5), lamotrigine (LTG) (n=1) and levetiracetam (LEV) (n=1). @entity1 with @entity3762 ( @entity3762 ) suffered aggravation with CBZ in 17 cases, VPA - in 6, TPM - in 6, LTG - in 1 and LEV - in 1. CBZ aggravated absences in @entity1 with @entity2048 ( @entity2048 ) were found in 5 cases of 17 (29.4%), with @entity2048 ( @entity2048 ) - in 1 of 24 (4.2%), absences and @entity2045 in @entity3149 ( @entity3149 ) - in 9 of 47 (19.1%), absences with eyelid @entity2045 (Jeavons syndrome) - in 2 of 11 (18.2%). @entity410 aggravations with different AEDs were observed in 13 @entity1 . This pattern of aggravation was associated with resistant @entity302 and poor prognosis. @entity410 aggravation due to increasing the dose of AEDs was found in 10 cases and associated with resistant @entity302 and poor outcome. "True" aggravation was associated with CBZ in 34 @entity1 , including 16 @entity3762 @entity1 , with TPM - in 13, VPA - 5, LTG - 5, LEV - 2 and with clonazepam in 1 @entity1 . Most often @entity410 aggravation was associated with CBZ in @entity3762 @entity1 (8.3%), and with LTG, TPM and CBZ in @entity1 with other @entity302 (non @entity3762 ): 4.9%, 4% and 3.7%, respectively. Conclusions. Different AEDs can cause aggravation. @entity410 aggravation after generic substitution was characteristic of TPM most frequently. @entity410 aggravation with different AEDs and due to increasing the dose of AEDs was associated with poor outcome. In all cases, @entity410 aggravation was more frequently caused by LTG (4.7%), CBZ (3.7%) and TPM (3.3%). To reduce the risk of aggravation, slow AEDs titration and keeping a diary of @entity410 are required.
