Humoral autoimmune manifestation in XXXX .

@entity1 @entity3935 @entity4941 @entity1378 @entity3745
To study the autoimmune manifestations in @entity4941 ( @entity4941 ), the patterns of thyroid antibodies, @entity3745 and circulating immune complexes were investigated in 10 @entity1 during the course of the disease. Eight @entity1 were @entity3935 at diagnosis, and became euthyroid during recovery with a median observation of 8 months (4-30 months). Thyroid stimulating immunoglobulins were measured as TSH binding inhibiting immunoglobulins (TBII) and as thyroid stimulating antibodies (TSAb). TBII were present in all @entity1 at least once during the observation period and remained detectable in six @entity1 after recovery. TSAb were detected in three @entity1 without relation to the @entity1378 state. @entity3745 antibodies (TgAb) were present in four @entity1 and persisted in three, while microsomal antibodies (MAb) were negative. @entity3745 (Tg) in the TgAb negative @entity1 (n = 6) was high at diagnosis (median 229 micrograms/l, range 55-375) and fell rapidly during the course of @entity4941 . Circulating immune complexes (CIC), which were found in all @entity1 , reached maximal levels shortly after the onset of the disease and persisted after recovery. No correlation could be demonstrated between the different thyroid antibodies, and there was no clear relation between the levels of CIC and presence of the autoantibodies. However, the changes in CIC paralleled the changes in TBII, and it is suggested that immune complex formation is a major feature of the regulatory mechanisms controlling the immune responses in @entity4941 .
