XXXX of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis.

@entity1 @entity1917 @entity5 @entity189 @entity876 @entity16104 @entity150 @entity14 @entity21526 @entity7597
PURPOSE: Urachal @entity150 is a rare @entity5 . Its histological phenotype is similar to that of primary bladder and @entity14 . The aim of this study was to explore the expression and prognostic relevance of 6 select protein markers of @entity150 , including @entity876 , Ki67, @entity16104 , @entity7597 , @entity21526 and @entity1917 , which were formerly shown to be prognostic in @entity189 and @entity14 . MATERIALS AND METHODS: Clinical and followup data were obtained on a total of 26  @entity1 with @entity150 treated at 2 university hospitals. Immunohistochemical analysis of @entity876 , Ki67, @entity16104 , @entity7597 , @entity21526 and @entity1917 expression was performed in samples from 15 @entity1 . Clinicopathological parameters and immunohistochemical results were tested for prognostic value on univariable and multivariable analyses. RESULTS: Followup was 50 months. Five-year overall and progression-free survival was 46% and 32%, respectively. On multivariable analysis a positive resection margin was an independent predictor of poor overall survival (p  =  0.025). @entity16104 (p = 0.0431), @entity21526 (p = 0.0052), Ki67 (p = 0.0006) and @entity876 (p = 0.0024) expression rates were significantly increased in @entity150 cells compared to normal urothelium. @entity21526 was elevated in Sheldon @entity5 stage IIIA compared to IIIB or greater (p = 0.0048). None of the analyzed protein markers was associated with survival. CONCLUSIONS: The independent prognostic value of a positive resection margin underlines the importance of complete surgical removal of @entity150 combined with en bloc resection of the median umbilical ligament and umbilicus. Our results in a limited number of samples show that Ki67, @entity876 , @entity16104 and @entity21526 expression is enhanced but has no prognostic significance in @entity150 .
