Proprotein Convertase Subtilisin/Kexin type 9, C-Reactive Protein, Coronary Severity, and Outcomes in XXXX With Stable Coronary Artery Disease: A Prospective Observational Cohort Study.

@entity1 @entity64 @entity583 @entity756 @entity1459 @entity453 @entity204
UNASSIGNED: @entity756 ( @entity756 ) is suggested as a novel factor associated with @entity453 ( @entity453 ). However, few studies have comprehensively evaluated plasma @entity756 with cardiovascular risk till now. Hence, we aimed to prospectively investigate the association between baseline @entity756 and cardiovascular risk graded with number of risk factors (RFs), coronary severity, and outcomes in @entity1 with stable @entity453 .Baseline characteristics and biomarkers were measured in 616 consecutive, nontreated @entity1 with stable @entity453 . Coronary severity was measured using SYNTAX, Gensini, and Jeopardy scoring systems. @entity1 were then received treatment and followed for a median of 17 months. The primary endpoints were @entity204 , @entity64 , @entity583 ( @entity583 ), post-discharge revascularization, or @entity1459 ( @entity1459 ).Overall, follow-up data were obtained from 603 @entity1 . A total of 72 (11.9%) @entity1 presented with at least 1 major adverse cardiovascular event (MACE) (4 @entity204 , 4 @entity64 , 6 MIs, 28 revascularizations, and 30 UAs). At baseline, @entity756 was increased with an increasing number of RFs and positively associated with coronary severity scores (P<0.05, all). After follow-up, those with MACE had a higher baseline @entity756 , hs-CRP, and coronary scores than those without (P<0.05, all). Multivariate analysis showed that @entity756 , hs-CRP, and coronary scores were independently predictive for MACEs (P<0.05, all). Interestingly, more significant predictive values of @entity756 in medical-alone-treated population but no such associations in revascularization-treated @entity1 were found.Together, plasma @entity756 , as well as hs-CRP and coronary scores, could independently predict MACEs in @entity1 with stable @entity453 .
