Gelatin sealing sheet for arterial hemostasis and anti-adhesion in vascular surgery: a XXXX model study.

@entity32 @entity548 @entity235 @entity86 @entity35
BACKGROUND: The bilayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE: To examine the feasibility of gelatin sealing sheets using a @entity235 @entity548 model. METHODS: In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in @entity35 . For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of @entity235 were pricked with syringe needle to make a small hole and a gelatin (i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop @entity548 (n=8). After discontinuation of the @entity548 , the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS: From the degradation study, 4 h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, @entity548 from the needle hole on @entity235 femoral arteries was effectively stopped. @entity86 and @entity32 at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS: The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing @entity86 .
