Early left XXXX and cardiovascular risk factors in 1,371 asymptomatic subjects with normal ejection fraction: a tissue Doppler study.

@entity10345 @entity67 @entity1002 @entity299
BACKGROUND: Nowadays early diagnosis of @entity1002 represents a major challenge in asymptomatic subjects with cardiovascular (CV) risk factors. Tissue Doppler imaging (TDI) recently emerged as an important tool with clinical relevance in several @entity299 . AIM: To evaluate the ability of @entity10345 in detecting early longitudinal @entity67 in asymptomatic subjects, with LV ejection fraction >55%, normal diastolic function, and its relationship with CV risk factors. METHODS: A total of 1,371 subjects (median age 60 years, 595 males) formed our study population: Controls, 265 healthy subjects; Group I, 434 subjects with one CV risk factor; Group II, 401 subjects with two CV risk factors; Group III, 271 subjects with >=  3 CV risk factors. All subjects underwent a comprehensive standard echo Doppler evaluation, including PW-TDI study. RESULTS: Diastolic parameters such as (E\A, A-wave, Em\Am; E\Em) were able to discriminate the number of CV risk factors. The only systolic parameter that progressively reduced by increasing the number of CV risk factors was @entity1002 (Sm), (P < 0.0001). At multivariate analysis, the only functional parameter able to predict the increasing number of CV risk factors was Sm (P < 0.001). CONCLUSIONS: TDI is able to identify early @entity1002 in presence of apparently normal systolic and diastolic function and progressively impairs with increasing CV risk factors. These findings could be clinically relevant in identifying asymptomatic subjects who need a early tailored preventive treatment.
