Long-term efficacy of electroconvulsive therapy combined with different antipsychotic drugs in previously resistant XXXX .

@entity1 @entity3216 @entity161 @entity1037 @entity1090
BACKGROUND: In treatment-resistant @entity161 a combination of ECT with antipsychotics has been reported to have superior outcomes compared to other strategies, however the results were inconsistent. We investigated the long-term effects of the combination of unilateral, non-dominant hemisphere ECT with three antipsychotics. SUBJECTS AND METHODS: The clinical study was a naturalistic, prospective, open-labeled, active-controlled study in adult outpatients of both genders suffering from treatment-resistant @entity161 with a follow up of 2 years. The @entity1 received @entity3216 (n=17, 100-400mg/day, PO), @entity1090 (n=26, 2-8 mg/day, PO) or @entity1037 (n=27, 5-10mg/day, PO). Unilateral ECT was applied in 1 unit (0.5A, 0.8 mS) in six single applications, once a week and further according to the clinical need, in fortnight steps. Clinical efficacy was established using the PANSS and CGI psychometric scales. RESULTS: According to the results, the most effective treatment mode was @entity1037 plus ECT, then @entity1090 plus ECT, while @entity3216 plus ECT had lower clinical efficacy. @entity1037 plus ECT was significantly superior in all scale scores vs @entity3216 plus ECT, as well as @entity1090 plus ECT except for PANSS-P (t=1.85, p>0.05). During the study, 38 of 70 @entity1 were withdrawn due to treatment failure (n=21), side effects (n=6) and non-compliance (n=11). CONCLUSION: The combination of novel antipsychotics and ECT can be used safely and effectively in treatment-resistant @entity161 .
