Computational modelling of clot development in @entity1 - specific XXXX cases.

@entity432 @entity1 @entity439 @entity438
BACKGROUND: In @entity438 , clotting can either stabilise the @entity439 sac via @entity439 , or it can have a detrimental effect by giving rise to @entity432 . OBJECTIVE: The work presented in this study details the development of an in silico model that combines, all the salient, clinically relevant features of @entity438 clotting. A comprehensive computational model of clotting that accounts for biochemical complexity coupled with three-dimensional haemodynamics in image-derived @entity1 @entity439 , and in the presence of virtually implanted interventional devices is presented. METHODS: The model is developed and presented in two stages. First, a two-dimensional computational model of clotting is presented, for an idealised geometry. This enables verification of the methods with existing, physiological data before the pathological state is considered. This model is used to compare the results predicted by two different underlying biochemical cascades. The two-dimensional model is then extended to image-derived, three-dimensional aneurysmal topologies by incorporating level set methods, demonstrating the potential use of this model. RESULTS AND CONCLUSION: As a proof of concept, comparisons are then made between treated and untreated @entity439 . The prediction of different clotting outcomes for different @entity1 demonstrates that with further development, refinement and validation, this methodology could be used for @entity1 -specific interventional planning. This article is protected by copyright. All rights reserved.
