The potential role of XXXX as an oncogene: a genotranscriptomic/proteomic meta-analysis.

@entity1 @entity0 @entity54918 @entity5 @entity1583
UNASSIGNED: Epigenetic complexes control various pathways within the cells. Their abnormalities can be involved in the initiation and the progression of different types of @entity5 . Nucleosome remodeling and deacetylase (NuRD) is an epigenetic complex that comprises several subunits such as @entity54918 . Although @entity54918 is reported as a @entity5 suppressor in some of the @entity1583 , its function is still challenging in other @entity5 . Our study aimed at investigating the role of @entity54918 in different types of @entity5 . We conducted a meta-analysis of @entity54918 in @entity1 @entity5 at genomic, transcriptomic, and proteomic levels. For this purpose, we acquired the data from several databases, and tried to statistically integrate and analyze the data in order to find the potential role of @entity54918 in different @entity5 . The results demonstrated that although @entity54918 has been previously known as a @entity5 suppressor gene, it was remarkably overexpressed in many @entity0 . Notably, @entity54918 was under-expressed in a few types of @entity5 , including @entity5 . Moreover, the results indicated that although the mutation rate of @entity54918 is relatively low, it is mutated in some @entity5 types.   In addition, our data for 40 epigenetic genes showed that missense and nonsense mutations were associated with overexpression and under-expression, respectively. Our results suggest that @entity54918 may function as an oncogenic factor in several types of @entity5 . We also hypothesize that @entity54918 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of @entity54918 in @entity5 types.
