Hemoglobin- and myoglobin-induced XXXX in @entity35 : role of @entity68 in nephrotoxicity.

@entity8 @entity5532 @entity63 @entity26 @entity8763 @entity653 @entity3787 @entity1234 @entity810 @entity35 @entity68 @entity1446
In @entity63 @entity810 @entity26 free radicals may mediate injury. In addition, @entity68 appears to play a critical role in @entity3787 radical formation and lipid peroxidation during reperfusion of @entity63 kidneys. To determine whether @entity68 may play a similar role in pigment (heme protein)-induced @entity810 , we studied the effects of the @entity68 chelator @entity5532 in two experimental models of pigment-induced @entity810 , intramuscular @entity653 injection and intravenous hemoglobin infusion without and with concurrent @entity63 in the @entity35 . Intramuscular injection of 50% @entity653 (5 ml/kg) caused inulin clearance to fall to 0.13 +/- 0.03 (SE) ml/min (normal value, 1.0-1.2 ml/min). Continuous infusion of @entity5532 beginning at the time of @entity653 injection significantly attenuated this @entity8 . @entity5532 -treated animals had an inulin clearance of 0.37 +/- 0.06 ml/min (P less than 0.01). @entity653 injection was also associated with significant lipid peroxidation, measured as renal @entity1234 content. @entity5532 -treated @entity653 -injected @entity35 had renal @entity1234 content not significantly different from control animals. In another model of @entity1446 pigment-induced @entity8 , hemoglobin was infused to produce @entity8763 . Inulin clearance 1 h after hemoglobin infusion was significantly reduced to 0.84 +/- 0.5 ml/min (P less than 0.025). Infusion of @entity5532 after hemoglobin prevented the hemoglobin-induced decrease in inulin clearance. Thirty minutes of @entity8 followed by infusion of hemoglobin resulted in more severe @entity8 with inulin clearance of 0.54 +/- 0.08 ml/min. @entity5532 infused at the time of reperfusion attenuated the fall in glomerular filtration rate after @entity63 and hemoglobin infusion:inulin clearance 1.04 +/- 0.07 (P less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
