Transanal endoscopic microsurgery for XXXX . Long-term oncologic results.

@entity5 @entity1 @entity652
PURPOSE: Local excision of malignant @entity5 remains controversial due to the lack of prospective studies. The principal aim of this paper is to analyze survival and recurrence of @entity1 with @entity5 who were operated by transanal endoscopic microsurgery with curative intention. METHODS: In 1997, we started a prospective protocol for @entity1 who had T1/T2 @entity5 : transanal local full-thickness excision was considered curative in T1 low risk (group A); @entity1 with T1 high-risk and T2 low-risk @entity5 received postoperative radiotherapy (group B). From 1997 to 2006, 88 @entity1 were enrolled. Sixty eight entered the study after the preoperative workup and 20 @entity1 with an initial diagnosis of @entity652 after postoperative definitive pathological assessment. RESULTS: After definitive histological findings, 54 @entity1 were to group A, 28 to group B, and 6 had immediate radical surgery. One @entity1 was lost for follow-up. At a mean follow-up of 71 months, 7 (4 from group A and 3 from group B) out of 81 @entity1 recurred. Five-year overall survival was of 94% and @entity5 -specific survival of 96%. CONCLUSIONS: Our data support that transanal endoscopic microsurgery is an adequate treatment for T1 low-risk @entity5 , and no additional measures are required. For T2 low-risk lesions, our study showed a higher local recurrence rate than that reported after radical surgery but a similar survival outcome.
