Receptor for Hyaluronic Acid-Mediated Motility is Associated with Poor Survival in XXXX .

@entity1 @entity788 @entity1124 @entity41 @entity146 @entity5 @entity16104
Receptor for hyaluronic acid (HA)-mediated motility ( @entity16104 ) is a nonintegral cell surface receptor involved in the @entity146 phenotype in a wide spectrum of @entity1 @entity5 , but the significance of @entity16104 in @entity1124 ( @entity1124 ) remains unknown. In this study, we investigated the expression of @entity16104 and its clinical relevance in @entity1124 . @entity16104 mRNA expression was examined in 8 @entity1124 cell lines and in primary @entity788 and adjacent non- @entity5 tissues from 14 @entity1 using real-time RT-PCR. Western blotting was carried out to analyze the expression of @entity16104 protein in @entity1124 cell lines. We also investigated the expression patterns of @entity16104 protein in tissue samples from 70 @entity1124 @entity1 using immunohistochemistry. The @entity16104 mRNA expression was increased in some @entity1124 cell lines as compared to a non-tumorous pancreatic epithelial cell line HPDE. The @entity16104 mRNA expression was significantly higher in @entity1124 tissues as compared to corresponding non-tumorous pancreatic tissues (P < 0.0001). The @entity16104 protein expression was higher in the vast majority of @entity1124 cell lines relative to the expression in HPDE. The immunohistochemical analysis revealed strong expression of @entity16104 in 52 (74%) @entity1124 tissues. Strong expression of @entity16104 was significantly associated with a shorter survival time (P = 0.038). In multivariate analysis, @entity5 stage (P = 0.039), @entity41 (P = 0.015), and strong @entity16104 expression (P = 0.034) were independent factors predicting poor survival. Strong expression of @entity16104 may predict poor survival in @entity1124 @entity1 and may provide prognostic and, possibly, therapeutic value.
