IFN Regulatory Factor-1 Modulates the Function of Dendritic Cells in XXXX with @entity1187 .

@entity1 @entity1187 @entity9688 @entity3963 @entity453 @entity731 @entity1366
BACKGROUND: @entity731 is widely recognized as a complex inflammatory disease involving pathogenic immune response of T cells and antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages. Accumulating evidence has revealed that mature DCs play critical roles in the differentiation of effector T cells into CD4+ T cells, which effectively participate in the onset of @entity1187 ( @entity1187 ). @entity9688 has been shown to be involved in various immune processes. The role of @entity9688 in DCs in the pathogenesis of @entity1187 has not been investigated. METHODS AND RESULTS: We examined the relative mRNA and protein expression of @entity9688 in @entity1 monocyte-derived DCs in @entity1 with @entity453 ( @entity453 ). The overexpression or silencing of @entity9688 expression in DCs in @entity1 with @entity1187 was performed to explore the possible role of @entity9688 in the maturation and function of DCs involved in @entity1187 . The results showed that the relative expression of @entity9688 in DCs is obviously increased in @entity1 with @entity1187 . The overexpression or silencing of @entity9688 expression could effectively promote or attenuate the maturation and function of DCs. In addition, we revealed that the MAPK pathway (phosphorylation of JNK, @entity3963 and @entity1366 ) might be downstream of @entity9688 signalling pathway in activation of circulating DCs in @entity1187 @entity1 . CONCLUSION: The present data demonstrate that @entity9688 could effectively promote the immune maturation and function of DCs in @entity1187 @entity1 .    2015 S. Karger AG, Basel.
