@entity835 and severity of psychotic and affective disorders in Israeli XXXX inpatients.

@entity1 @entity162 @entity308 @entity132 @entity146 @entity2948 @entity835 @entity915 @entity1957 @entity148 @entity161 @entity716 @entity2701
The influence of @entity835 abuse on the severity of existing @entity716 and affective symptoms is still unclear. Among 470 consecutively admitted @entity716 or affective @entity1 , 54 active (in the previous month) @entity835 abusers were detected via urine tests (Sure Step TM kits; Applied Biotech Inc, San Diego, @entity2948 ) and Structured Clinical Interview for DSM-IV ( @entity915 - IV) questionnaire. In 24 cases, substances other than @entity835 were abused; 392 @entity1 were nonabusers. All @entity1 were diagnosed according to the Diagnostic and Statistical Manual of @entity146 , Fourth Edition, criteria. The following rating scales were used: Hamilton Depression Rating Scale (HAM-D-21), Positive and Negative Syndrome Scale (PANSS), and Young Mania Rating Scale (YMRS). @entity835 abusers (n = 54) were significantly younger and more frequently males than nonuser @entity1 . In this group, there were more @entity161 @entity1 and fewer affective and @entity148 @entity1 (chi(2) = 11.76; P < .01). The double-diagnosed @entity1 had more prominent @entity716 symptoms than the nonusers (n = 392)-PANSS positive: 19.056 +/- 8.30 vs 16.128 +/- 8.031 (P < .02; t(446) = 2.510). The difference was statistically significant for hallucinatory behavior, excitement, grandiosity, and hostility. General PANSS scale rate of abusers was lower: 33.012 +/- 9.317 vs 37.3575 +/- 11.196 (P < .01; t = 2.727), especially for @entity308 , @entity148 , somatic concern, guilt feelings, @entity2701 , @entity1957 , and @entity132 . Rates of PANSS negative scale of abusers and nonusers were not significantly different (13.815 +/- 6.868 vs 14.983 +/- 6.446) except for lower rates of social withdrawal and stereotyped thinking for abusers. No significant difference in general level of @entity162 (YMRS) between abusers and nonusers was observed (6.778 +/- 10.826 vs 4.910 +/- 7.754), but severity of thought/language disturbances and poor insight was found significantly higher in the abusers. @entity835 abusers are obviously less depressive (HAM-D): 5.944 +/- 10.291 vs 12.896 +/- 13.946 (P < .0005, t = 3.535). Such differences were observed in the high number of the subscales. Abusers' rates were higher (although not significantly) for paranoid symptoms and general somatic symptoms. @entity835 possibly produces some antidepressive and anxiolytic effect on @entity716 and affective inpatients. The "price" of this effect is often an exacerbation of @entity716 and some @entity162 .
