Developmental expression patterns of chemokines CXCL11, CXCL12 and their receptor CXCR7 in testes of common marmoset and XXXX .

@entity1 @entity1570 @entity4112 @entity372 @entity3392
UNASSIGNED: The chemokine receptor @entity4112 interacts with the chemokines @entity372 and @entity1570 . During development, this ligand receptor system (C-X-C) provokes cell-type-specific responses in terms of migration, adhesion or ligand sequestration. It is active in @entity3392 and rodents but no data are available for its presence or function in primate testes. Real-time quantitative polymerase chain reaction was performed in monkeys to detect @entity372 , @entity1570 and @entity4112 . At the protein level, @entity1570 and @entity4112 were localized in the testes of the marmoset (Callitrix jacchus)  whereas @entity4112 patterns were determined for various stages in @entity1 testes. Morphometry and flow cytometry were applied to quantify @entity4112 -positive cells in monkeys. Transcript levels and protein expression of @entity4112 were detectable throughout testicular development. In both species, @entity4112 protein expression was restricted to premeiotic germ cells. In immature marmoset testes, 69.9  %        9  % of the total germ cell population were labelled for @entity4112 , whereas in the adult, 4.7  %        2.7  % were positive for @entity4112 . @entity1570 mRNA was detectable in all developmental stages in marmosets. The @entity1570 protein was exclusively localized to Sertoli cells. This pattern of @entity1570 / @entity4112 indicates their involvement in regulatory processes that possibly orchestrate the interaction between undifferentiated germ cells and Sertoli cells.
