@entity2390 augments the effects of XXXX in treating a @entity35 @entity96 model.

@entity5956 @entity35 @entity96 @entity5 @entity2390 @entity432 @entity6962
BACKGROUND/AIMS: To observe if @entity2390 can augment the effects of @entity432 for transplanted @entity5 in @entity35 's liver. METHODOLOGY: Walker 256 @entity6962 was transplanted into @entity35 's liver to create the @entity96 model. Hepatic arterial ligation was used to block the hepatic arterial blood supply. @entity35 bearing @entity5 were divided into three groups: control group, HAL (hepatic arterial ligation) group, and HAL plus @entity2390 group. Change of @entity5 volume and @entity5 growth inhibiting rate after therapy were evaluated. @entity5956 labeling assay was used to analyze the blood perfusion of @entity5 (the labeled cells' number presenting blood perfusion). Expression of vascular endothelial growth factor and matrix metalloproteinase-1 mRNA was detected by in situ hybridization, and the level of serum vascular endothelial growth factor was assayed by ELISA. RESULTS: Six days after hepatic arterial ligation, the mean @entity5 volume in control group, HAL group, and HAL plus @entity2390 group was 0.103 +/- 0.043 cm3, 0.030 +/- 0.018 cm3, and 0.016 +/- 0.005 cm3, respectively. The @entity5 volume in the two behind groups was smaller than that in the control group (P < 0.01), and the @entity5 growth-inhibiting rate was 70.8%, and 84.5%, respectively. Compared with the HAL group, the @entity5 volume in HAL plus @entity2390 group decreased significantly (P < 0.05). @entity5956 labeled cells' number in control group, HAL group, and HAL plus @entity2390 group was 369.7 +/- 30.2, 344.1 +/- 26.0, and 323.2 +/- 40.4, respectively. The number in HAL combined with @entity2390 group decreased significantly compared with that in control group (P < 0.05), which suggested that the blood perfusion of @entity5 in HAL plus @entity2390 group decreased significantly. The expression of vascular endothelial growth factor and matrix metalloprotenase-1 mRNA decreased slightly, but not significantly in HAL plus @entity2390 group compared with that in HAL group (P > 0.05). CONCLUSIONS: The results suggest that @entity2390 can promote the effects of hepatic @entity432 in @entity35 's liver. Decreasing the blood perfusion of @entity5 after hepatic arterial blockage maybe one of its major mechanisms.
