The effects of intraoperative intravenous XXXX on gastric intramucosal PCO2.

@entity1 @entity681 @entity26 @entity3652 @entity1341 @entity1338
To investigate the effects of @entity1338 given as an anesthetic adjunct on splanchnic perfusion, we determined intramucosal gastric PCO2 using gastric tonometry in 60 @entity1 scheduled for large intestine surgery. After induction of anesthesia, @entity1 were randomly assigned to four groups. @entity1 in Group 1 received an IV infusion of @entity681 (0.2 microg x kg(-1) x h(-1)); @entity1 in Group 2 received an IV infusion of @entity1338 (4 microg/kg in 20 min followed by 2 microg x kg(-1) x h(-1)); @entity1 in Group 3 received an IV infusion of @entity3652 (0.5 mg/kg followed by 0.25 mg x kg(-1) x h(-1)); @entity1 in Group 4 received an epidural infusion of @entity1341 (7 mL of 0.5% followed by 5 mL/h of 0.25%). Gastric intramucosal PCO2 was assessed immediately before skin incision and every hour during surgery using a nasogastric tube. A last measurement was taken after skin closure. An arterial sample was collected simultaneously to measure arterial PCO2. @entity26 consumption (VO2/min) was continuously recorded. Gastric intramucosal PCO2 significantly increased during surgery in all groups independent of the anesthetic technique considered (P < 0.01) and was not related to metabolic changes or blood pressure variations. This increase, however, remains in the physiologic range. In conclusion, our results demonstrate that @entity1338 given as an anesthetic adjutant at the dose used has no deleterious effect on splanchnic perfusion during colonic surgery. IMPLICATIONS: IV @entity1338 given as an anesthetic adjunct at a dose of 4 microg/kg in 20 min, followed by 2 microg x kg(-1) x h(-1), has no deleterious effect on splanchnic perfusion during colonic surgery.
