Evaluation of the 3D spatial distribution of the XXXX / @entity3151 ratio in bone using computed-tomography dual-energy analysis.

@entity3604 @entity32 @entity174 @entity1109 @entity95 @entity79 @entity460 @entity3151 @entity9495
PURPOSE: The @entity460 / @entity3151 ( @entity9495 /P) ratio was shown to vary between healthy bones and bones with @entity1109 . The relation of the @entity9495 /P ratio to @entity79 remains under investigation. To study this relation and determine if the ratio can be used to predict @entity174 , a non-invasive 3D imaging technique is required. The first aim of this study was to test the effectiveness of a computed-tomography dual-energy analysis (CT-DEA) technique developed to assess the @entity9495 /P ratio in bone apatite (collagen-free bone) in identifying differences between healthy and @entity32 -mediated @entity3604 (IMO) bones. The second aim was to extend the above technique for its application to a more complex structure, intact bone, that could potentially lead to clinical use. METHODS: For the first aim, healthy and IMO @entity95 cortical bone apatite samples were assessed. For the second aim, some changes were made to the technique, which was applied to healthy and IMO intact bone samples. RESULTS: Statistically significant differences between healthy and IMO bone apatite were found for the bulk @entity9495 /P ratio, low @entity9495 /P ratio proportion and interconnected low @entity9495 /P ratio proportion. For the intact bone samples, the bulk @entity9495 /P ratio was found to be significantly different between healthy and IMO. CONCLUSIONS: Results show that the CT-DEA technique can be used to identify differences in the @entity9495 /P ratio between healthy and @entity3604 , in both bone apatite and intact bone. With quantitative imaging becoming an increasingly important advancement in medical imaging, CT-DEA for bone decomposition could potentially have several applications.
