Interleukin 1B variant XXXX (rs1143623) influences @entity412 and @entity650 metabolism.

@entity2298 @entity650 @entity72302 @entity1 @entity1356 @entity1674 @entity10194 @entity412 @entity165
CONTEXT: @entity1356 ( @entity1356 or @entity1356 ), a key modulator of the immune response, exerts its functions mainly via @entity650 regulation. Fatty meals cause transient @entity2298 and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility. OBJECTIVE: We evaluated the influence of a genetic variant located in the promoter region of @entity1356 ( @entity72302 ) on fasting and postprandial lipids and @entity650 . DESIGN, SETTING, AND @entity1 : A total of 477 @entity1 over age 65 yr were genotyped for @entity1356 @entity72302 , and we evaluated fasting lipids depending on genotype. Then, 88 healthy young @entity1 were also genotyped and were fed a @entity10194 -rich meal. Serial blood samples were drawn for 11 h after the meal, and lipid fractions and @entity650 were assayed. MAIN OUTCOME AND INTERVENTIONS: Fasting lipids were studied in the aged @entity1 . Fasting and postprandial measurements of lipids and @entity650 were performed in the healthy young @entity1 . RESULTS: In the aged @entity1 , CC subjects (minor allele homozygotes) showed higher @entity412 (P = 0.002) and @entity165 (P = 0.011) levels. Healthy young male carriers of the minor C allele showed higher postprandial @entity1674 (P = 0.037), and those carried into large @entity412 -rich lipoproteins (P = 0.004). In addition, they showed higher postprandial @entity650 concentrations (P = 0.008). CONCLUSIONS: Our work shows that inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL gene variant have altered lipid metabolism. To reinforce these gene-phenotype findings, @entity650 (the natural effector of @entity1356 ) was increased in these @entity1 .
