Decreased right hippocampal volumes and neuroprogression markers in adolescents with XXXX .

@entity1 @entity162 @entity4150 @entity2252 @entity1091
OBJECTIVES: The aim of the present study was to assess differences and correlations between the hippocampal volumes (HCVs), serum @entity4150 ( @entity4150 ), and @entity2252 ( @entity2252 ) levels in adolescents with @entity162 ( @entity162 ) compared to healthy controls. METHODS: Using structural magnetic resonance imaging, we compared HCVs of 30 @entity1 with euthymic @entity162 who were already enrolled in a naturalistic clinical follow-up. For comparison, we enrolled 23 healthy controls between the ages of 13 and 19. The boundaries of the hippocampus were outlined manually. The @entity2252 and @entity4150 serum levels were measured with the sandwich ELISA. RESULTS: The groups did not differ in the right or left HCVs or in the @entity4150 or @entity2252 serum levels. However, negative correlations were found between the right HCVs and the duration of the disorder and medication and positive correlations were found between the duration of the medications and the @entity4150 and @entity2252 levels in the @entity1 group. Additionally, positive correlations were found between the follow-up period and left normalized HCVs in both the @entity162 and @entity1091 -treated groups. CONCLUSIONS: The right HCVs may vary with illness duration and the medication used to treat @entity162 ; @entity4150 and @entity2252 levels may be affected by long-term usage. Further research is needed to determine whether these variables and their structural correlates are associated with clinical or functional differences between adolescents with @entity162 and healthy controls.    2015 S. Karger AG, Basel.
