The preliminary experiences of XXXX and literature review.

@entity1 @entity5 @entity1358 @entity19409 @entity490 @entity3 @entity811 @entity5492
Xp11.2 @entity1358 ( @entity1358 ) is rare and predominantly found in @entity1 and young adults. Because of the property of overexpressed @entity19409 ( @entity19409 ) fusion protein, immunohistochemical (IHC) staining with @entity19409 antibody makes an excellent diagnostic tool. This study analyzed preliminary experiences of eight Xp11.2 translocation RCCs in our institution between 2007 and 2012. In four males and four females with a mean age of 28.4 years. Xp11.2 translocation RCCs were diagnosed. @entity19409 IHC stain was positive in all @entity5 specimens. As the initial presentation, four @entity1 suffered from @entity490 , three cases had gross @entity811 , and one case had @entity5492 caused by existing lung @entity3 . The @entity5 was located in the right kidney (75%) with mean diameter of 5.85    2.64 cm. Three cases (38%, 3/8) presented with lymph node @entity3 at the time of diagnosis. In five cases (63%, 5/8), the initial diagnosis was Stage III and IV. Treatment included open surgery (one partial nephrectomy and five radical nephrectomies), cryoablation, immunotherapy, and target therapy. The mean follow-up time was 32 months. One @entity1 died after 23.4 months of follow-up. The application of @entity19409 IHC stain will improve the diagnostic accuracy for detecting XP11.2 @entity1358 . Surgery or cryoablation both had excellent prognosis in early stages. Although the disease is believed to be indolent, an increasingly aggressive clinical course should be kept in mind, especially for @entity1 and young adults.
