Tridax procumbens XXXX promote osteoblast differentiation and bone formation.

@entity1 @entity8087 @entity1841 @entity417 @entity625 @entity13062 @entity19 @entity565 @entity1066 @entity9332 @entity604 @entity170 @entity5298 @entity32968 @entity3088 @entity12017 @entity158 @entity6861 @entity210 @entity356
BACKGROUND: Tridax procumbens @entity3088 (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, @entity417 , @entity625 , @entity210 , @entity565 , @entity1066 , piles, and urinary problems, it is also used in treating @entity356 , body @entity158 , and @entity158 . TPFs have been reported to increase osteogenic functioning in mesenchymal stem cells. Our previous study showed that TPFs were significantly suppressed the @entity5298 -induced differentiation of osteoclasts and bone resorption. However, the effects of TPFs to promote osteoblasts differentiation and bone formation remain unclear. TPFs were isolated from Tridax procumbens and investigated for their effects on osteoblasts differentiation and bone formation by using primary @entity19 @entity9332 . RESULTS: TPFs promoted osteoblast differentiation in a dose-dependent manner demonstrated by up-regulation of alkaline phosphatase and osteocalcin. TPFs also upregulated osteoblast differentiation related genes, including osteocalcin, osterix, and @entity8087 in primary osteoblasts. TPFs treated primary osteoblast cells showed significant upregulation of bone morphogenetic proteins (BMPs) including @entity1841 , @entity13062 , and @entity12017 . Addition of @entity32968 , a @entity6861 specific-antagonist, inhibited TPFs induced upregulation of the osteocalcin, osterix, and @entity8087 . CONCLUSION: Our findings point towards the induction of osteoblast differentiation by TPFs and suggested that TPFs could be a potential anabolic agent to treat @entity1 with @entity604 -associated diseases such as @entity170 .
