Fast liquid ablation system for XXXX : a new minimally invasive thermal treatment.

@entity1 @entity32 @entity82 @entity548 @entity39 @entity3145 @entity1067 @entity8855 @entity1373 @entity3303
PURPOSE: We determined @entity1 tolerance and the sequence of histopathological changes of thermal injury and healing of the prostate after treatment with a novel, rapid, high temperature, liquid filled, flexible balloon thermotherapy system. MATERIALS AND METHODS: A total of 17 @entity1 scheduled for prostatic surgery received preoperative high temperature water balloon thermotherapy. In 13 @entity1 intraprostatic, urethral and rectal temperatures were continuously monitored and determined using stereotactic thermal mapping with the @entity1 under spinal anesthesia. The remaining 4 @entity1 had @entity3303 gel as the only method of pain control. @entity1 discomfort was recorded at all times during the procedure. After treatment a prostatic stent was left in place until surgery or spontaneous voiding. Serial sections of the resected prostates were evaluated pathologically with mapping. RESULTS: Treatment was well tolerated by all @entity1 . Prostates were enucleated (in 12 @entity1 ) or entirely removed (in 5) at a mean of 35 days (range 15 to 173) after thermotherapy. The predominant pathological findings in the early phase were uniform periurethral @entity548 , extensive urothelial denudation and varying degrees of @entity32 . The mean radial depth of @entity39 (from the urethra to the viable tissue border) was 0.9 cm (range 0.6 to 1.5) involving a mean of 16% of the @entity1067 (range 7.8% to 32%). In the late (resolution) phase necrotic tissue had been replaced by @entity3145 ( @entity82 and @entity8855 ) with a mean radial depth of 0.13 cm (range 0.01 to 0.24), and the urothelium had largely regrown along the urethra. CONCLUSIONS: The fast liquid ablation system for @entity1373 is a new minimally invasive treatment that induces considerable thermal injury to the prostate with uniform @entity39 and subsequent sloughing of dead tissue, allowing enlargement of the urethral lumen.
