Prospective, randomized, contralateral eye comparison of @entity6513 and @entity24505 for XXXX control in laser in situ keratomileusis and photorefractive keratectomy.

@entity1 @entity24505 @entity6513 @entity158
BACKGROUND: @entity6513 and @entity24505 are two of the most commonly used medications for providing topical anesthesia in laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). These agents have not been previously compared in a prospective manner to determine their efficacy in these settings. METHODS: This prospective, single-masked, randomized study comprised 256 eyes from 128 consecutive @entity1 being treated with LASIK or PRK who were randomized to receive @entity6513 in one eye and @entity24505 in the other. The @entity1 were blinded as to which anesthetic agent was used in each eye. Pain levels were graded on a 0-10 scale, and were assessed upon instillation, during surgery, immediately postoperatively, 30 minutes postoperatively, overnight, and on postoperative day 1. @entity1 were asked 30 minutes after surgery which anesthetic agent they would choose. RESULTS: Both anesthetic agents resulted in diminished amounts of subjective @entity158 in @entity1 undergoing LASIK and PRK. @entity6513 caused significantly more @entity158 upon instillation than @entity24505 for both LASIK and PRK @entity1 . LASIK @entity1 noted significantly less @entity158 30 minutes after surgery when treated with @entity6513 . Significantly more LASIK @entity1 preferred the eye treated with @entity6513 . These differences were not present in the PRK group. CONCLUSION: Both @entity6513 and @entity24505 are effective methods of topical anesthesia in LASIK and PRK. @entity6513 caused significantly more @entity158 upon instillation in all @entity1 , but resulted in greater analgesia 30 minutes after surgery in the LASIK group. @entity1 in the LASIK group expressed a preference for @entity6513 over @entity24505 . There was no significant drop preference among PRK @entity1 .
