Self-Report Daily Life Activity as a Prognostic Marker of XXXX .

@entity1 @entity2416 @entity63496
BACKGROUND: @entity2416 ( @entity2416 ) is a progressive disease, leading to substantial physical impairment. The distance walked in 6 min (6MWD) is a measure of exercise tolerance and is of prognostic relevance in @entity2416 . While 6MWD is a punctual measurement which may not be representative, self-reported daily life activity may represent the @entity1 ' functional capacity more globally even in less severe affected @entity1 . OBJECTIVES: We evaluated and characterized a simple classification system based on the @entity1 ' self-reported daily activity and analyzed if this would add significantly to the prognostic information of the 6MWD alone in @entity2416 @entity1 . METHODS: Daily life activity was assessed in @entity2416 (n = 156) @entity1 with standardized questions and categorized in activity classes (AC I-IV), comprising the less severe impaired in AC I and II. The 6MWD was also assessed. RESULTS: ACs were related to the lung functional impairment and inversely correlated to the 6MWD. Thirty-two @entity1 were in AC I/II, 98 in @entity63496 and 26 @entity1 in AC IV. Thirty-seven (23.7%) @entity1 died during a median follow-up of 14.9 months, comprising 1 @entity1 in AC I/II. In addition, a 6MWD <470 m predicted mortality. Combining AC I/II and a 6MWD >470 m identified a subgroup of @entity1 with favorable outcome. CONCLUSIONS: AC is a novel scoring system which can easily be obtained and correlates with lung functional and physical impairments as well as mortality. Moreover, AC adds prognostic information to the 6MWD.
