OS026. Study of neuroradiological and biochemical abnormalities in 100 XXXX with @entity1468 .

@entity1 @entity644 @entity410 @entity6220 @entity101 @entity75 @entity4 @entity11 @entity3036 @entity1468 @entity1188 @entity1779
INTRODUCTION: The posterior reversible @entity75 syndrome- @entity75 is recognised as the neuro radiologic abnormality in @entity3036 and with prompt treatment and delivery is usually reversible. OBJECTIVES: To study neuro radiological and biochemical abnormalities in severe @entity1468 and @entity3036 and their reversibility following delivery. METHODS: 100 @entity1 with severe @entity1468 and @entity3036 admitted to High risk unit at Gandhi Hospital, Secunderabad were studied between September 2008 and September 2010. Preeclamptic @entity1 who presented with complications of @entity1468 were included. @entity1 with @entity410 in the absence of @entity644 and @entity101 such as @entity6220 and known intracranial pathology were excluded . All the @entity1 were investigated for laboratory parameters such as renal function tests, platelet counts, liver function tests, coagulation profile, fundoscopy, in antepartum period and abnormal results were re-evaluated one week after delivery and in cases with persistent abnormal results at one week postpartum were again evaluated at the end of two weeks. Fifty @entity1 with @entity3036 among the study group underwent MR imaging of brain before delivery and thirty of these @entity1 who showed @entity75 underwent MR imaging postpartum. The different types images used are (i) T1 weighted image (ii) T2 weighted image - highly sensitive (iii) Flair image (iv) Diffusion Weighted image (DW) with Apparent Diffusion Co-efficient (ADC). MRI studies were performed in axial, coronal and sagittal axes in varying thickness of 5-10mm. The machine used was 1.5 Tesla Aves Siemens. The biochemical parameters and results of neuro imaging were studied antepartum and postpartum. RESULTS: Thirty six out of 50 @entity1 showed abnormal MRI findings. In 30 @entity1 (83%) findings were consistent with @entity75 . 3 cases (8%) showed @entity1188 , 1 case showed CSVT , 1 @entity1779 and 1 showed @entity11 undiagnosed in antenatal period . Out of 30 cases of @entity75 , 18(77%) cases showed reversal within 1 week postpartum, and 9(33%) cases within 2 weeks postpartum. 80-90% of the abnormal laboratory parameters reversed to normal within 1 week post partum. Abnormal persistent parameters reversed to normal in all cases at the end of 2 weeks. CONCLUSION: @entity75 ( @entity75 ) is a new clinico radiological entity resulting from vasogenic @entity4 in almost all cases of @entity3036 but rare with @entity1468 . In @entity3036 may be considered as clinical manifestation of @entity75 . Though MRI brain is a valuable diagnostic tool in evaluation of @entity3036 it is expensive, and less available. Repeat MRI investigations may not be necessary, as almost all cases of @entity75 are reversible. MRI brain in cases of @entity3036 also help to identify rare pathologies in the brain other than @entity75 , wrongly attributed to @entity3036 Though @entity1468 and @entity3036 are reversible, duration required for reversal is 1-2week period, during which period pathology is resolving but not recovered completely and complications can still occur. Hence, close observation is required in the first 1-2week postpartum.
