A Meta-Analysis of Site-Specific Effects of Cathodal Transcranial Direct Current Stimulation on Sensory Perception and XXXX .

@entity1 @entity158 @entity24873 @entity1118 @entity461
UNASSIGNED: The primary aim of our meta-analysis was to evaluate the effects of cathodal transcranial direct current stimulation (c-tDCS) on sensory and @entity158 thresholds ( @entity24873 and @entity461 ) in healthy individuals and @entity158 level (PL) in @entity1 with @entity1118 . Electronic databases were searched for c-tDCS studies. Methodological quality was evaluated using the PEDro and Downs and Black (D_B) assessment tools. C-tDCS of the primary motor cortex (S1) increases both @entity24873 (P<0.001, effect size of 26.84%) and @entity461 (P<0.001, effect size of 11.62%). In addition, c-tDCS over M1 led to @entity24873 increase (P<0.005, effect size of 30.44%). Likewise, PL decreased significantly in the @entity1 group following application of c-tDCS. The small number of studies precluded subgroup analysis. Nevertheless, meta-analysis showed that in all groups (except c-tDCS of S1) active c-tDCS and sham stimulation produced significant differences in @entity24873 / @entity461 in healthy and PL in @entity1 group. This review provides evidence for the site-specific effectiveness of c-tDCS in increasing @entity24873 / @entity461 in healthy individuals and decreasing PL in @entity1 with @entity1118 . However, due to small sample sizes in the included studies, our results should be interpreted with caution. Given that the level of blinding was not considered in the inclusion criteria, the results of the current study should be interpreted with caution.
