Effect of @entity1508 on renal hemodynamics during normovolemia and XXXX .

@entity235 @entity3485 @entity1508 @entity548
The effects of @entity1508 on renal hemodynamics under both normovolemic and @entity3485 conditions were investigated in chronically instrumented conscious @entity235 whose homeostatic mechanisms were not altered by the presence of preexisting drugs. Renal blood flow and aortic pressure were assessed by prior implantation of Doppler ultrasonic flow probes on the renal artery and a catheter in the descending aorta. Administration of @entity1508 to conscious normovolemic @entity235 (Group HN) resulted in 11-26% decreases in renal vascular resistance with no significant changes occurring in renal blood flow. In a second group of animals made @entity3485 while awake (Group AH), 30% of the blood volume was removed over one-half hour. In response to @entity548 , these conscious animals' renal blood flow did not significantly change from the normovolemic control, and renal vascular resistance significantly decreased. With no further intervention, renal vascular resistance and renal blood flow remained unchanged from the level achieved after the 30% @entity548 . A third group of animals (Group HH) was hemorrhaged in a manner similar to that of Group AH. They also showed no significant changes in renal blood flow and a significant decrease in renal vascular resistance in response to @entity548 . Thereafter, administration of @entity1508 , as in Group HN, to this group produced 11-23% decreases in renal vascular resistance with no significant decline in renal blood flow from the @entity3485 control levels established after @entity548 . The author concludes the following: administration of @entity1508 to normovolemic conscious @entity235 does not decrease renal blood flow; a moderate degree of @entity548 does not decrease renal blood flow in conscious @entity235 ; and administration of @entity1508 to acutely @entity3485 conscious @entity235 does not impair renal perfusion.
