Chronic manipulation of dietary salt modulates renal physiology and kidney XXXX receptor subtypes: functional and autoradiographic studies.

@entity10095 @entity2211 @entity1369 @entity11412 @entity935 @entity1219 @entity1372 @entity2865 @entity35 @entity10001
1. Compared to @entity35 maintained on the normal @entity1219 (0.33%) diet, animals maintained on the low @entity1219 (0%) diet for 4 weeks exhibited increased plasma @entity1369 and @entity2865 and decreased urinary @entity1372 excretion. 2. @entity35 maintained on the high @entity1219 (8%) diet for 4 weeks showed increased systolic blood pressure, water intake, urine volume, @entity1372 and @entity935 excretion and decreased plasma @entity1369 and glomerular filtration rate. 3. Administration of @entity10095 (10 mg/kg, po), but not @entity2211 to the high salt diet @entity35 attenuated the diuretic effect, indicating the involvement of @entity10001 rather than DA2 receptors. The @entity935 decarboxylase inhibitor, @entity11412 (30 mg/kg, i.p.), also reduced the high salt-induced diuresis. 4. Kidney sections from @entity35 fed the low @entity1219 diet showed a 63-100% decrease (P < 0.001-0.02) in cortical and medullary @entity10001 and DA2 binding sites, while @entity35 fed the high @entity1219 diet demonstrated only a 70% decrease (P < 0.01-0.02) in cortical @entity10001 binding, without affecting DA2 binding. 5. These data indicate that chronic modification of dietary salt profoundly affects the @entity1372 , water and @entity935 excretion and leads to selective modulation of renal @entity935 receptor subtypes.
