Ultrasound-guided high-intensity focused ultrasound treatment of XXXX -a multicenter experience.

@entity1 @entity0 @entity4530 @entity2117 @entity1557
BACKGROUND: The aim of our multicenter study was to assess the clinical outcome and safety of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in @entity1 with @entity0 ( @entity1557 ). METHODS: From May 2011 to February 2013, 42 @entity1 with 51 @entity1557 in one or both breasts were selected for treatment with US-guided HIFU. Eight of 51 @entity1557 were treated twice. @entity1 ' age ranged from 16 to 52  years (mean 32  years). All @entity1 with @entity1557 underwent core needle biopsy with histological confirmation. HIFU treatment was performed as an outpatient procedure under conscious sedation. Exclusion criteria were pregnant or lactating @entity1 , microcalcifications within the lesion at mammogram, history of @entity0 , previous laser or radiation therapy, and breast implant in the same breast. All @entity1 signed written informed consent. After the treatment, follow-up US with volume evaluation was performed at 2, 6, and 12  months. RESULTS: The @entity1557 mean baseline volume was 3.89  ml (0.34-19.66  ml). At 2-month follow-up, the mean volume reduction was 33.2%        19.1% and achieved significance at 6-month (59.2%        18.2%, p   <   0.001) and 12-month (72.5%        16.7%, p   <   0.001) follow-up. Related side effects as superficial skin burn with @entity4530 -like aspect in three @entity1 and @entity2117 over the treated area in one @entity1 were transient and resolved spontaneously. In one @entity1 , asymptomatic subcutaneous induration persisted at the end of the study. CONCLUSIONS: US-guided HIFU treatment is an effective noninvasive method for the treatment of breast @entity1557 and well tolerated by the @entity1 . Preliminary results are encouraging and show that HIFU could be an alternative to surgery for breast @entity1557 .
