Post-operative renal function following nephrectomy as part of en bloc resection of XXXX ( @entity242 ).

@entity1 @entity8818 @entity242 @entity5 @entity740 @entity1011 @entity454
BACKGROUND AND OBJECTIVES: Although resection of @entity242 with en bloc nephrectomy confers the potential benefit of improved @entity5 control, little has been published about the long-term post-operative renal function of these @entity1 . METHODS: Retrospective review of 54 @entity1 undergoing nephrectomy for @entity242 was performed. Clinicopathologic and treatment characteristics, pre- and post-operative @entity1011 ( @entity8818 ) values, and estimated glomerular filtration rates (eGFR) were recorded. The primary outcome measure was progression of @entity740 ( @entity740 ) stage. RESULTS: Median preoperative eGFR was 85   ml/min. Post-nephrectomy, median nadir eGFR was 44   ml/min, rebounding to 62   ml/min at median follow-up of 50 months. Of 49 @entity1 with preoperative eGFR >= 60   ml/min ( @entity740 stage 1,2), 51% preserved eGFR >= 60 postoperatively, whereas 49% progressed to @entity740 stage 3 (eGFR 30-59). Independent risk factors for progression of @entity740 stage were age and preoperative eGFR. Eleven @entity1 died of recurrent disease, whereas no @entity1 died of @entity454 ( @entity454 ) or required dialysis. CONCLUSIONS: Although progression of @entity740 stage occurs in nearly one-half of @entity1 followed for more than 4 years after nephrectomy for @entity242 , no @entity1 progressed to @entity454 or had a limitation in systemic therapy options, even with progression to @entity740 stage 3. J. Surg. Oncol. 2015 111:98-102.    2015 Wiley Periodicals, Inc.
