Vigor of peristalsis during multiple rapid swallows is inversely correlated with acid exposure time in XXXX with NERD.

@entity1 @entity1282
BACKGROUND: @entity1282 ( @entity1282 ) during high-resolution manometry (HRM) is increasingly utilized as provocative test to assess esophageal peristaltic reserve. The aim of this study was to evaluate the correlation between @entity1282 response and impedance and pH (MII-pH) parameters in endoscopy negative heartburn (ENH) @entity1 . METHODS: We enrolled consecutive ENH @entity1 , who underwent HRM and MII-pH study, with a selected MII-pH profile: abnormal MII-pH (pH+/MII+); normal MII-pH (pH-/MII-). HRM was performed with 10 @entity1282 ( @entity1282 ) and one @entity1282 . Mean distal contractile integral (DCI) during @entity1282 and @entity1282 were calculated. MII-pH parameters including acid exposure time (AET), reflux events, baseline impedance levels (BI) and the efficacy of chemical clearance evaluated with the postreflux swallow-induced peristaltic wave (PSPW) index were measured. KEY RESULTS: We analyzed 103 @entity1 : 49 MII+/pH+ (27 male), and 54 MII-/pH- (19 male). Mean age was similar between the two groups. As expected, mean AET and number of refluxes were higher in pH+/MII+ (p < 0.05). HRM was normal in all selected @entity1 . Mean DCI- @entity1282 was similar between two groups (p = n.s.). Mean DCI- @entity1282 - was higher in MII-/pH- vs MII+/pH+ (p < 0.05). The increase in DCI- @entity1282 was inversely correlated with AET (-0.699; p < 0.001) and directly correlated with BI values (0.631; p < 0.001) and PSPW index (0.626; p < 0.001). CONCLUSIONS _ INFERENCES: Following @entity1282 , @entity1 with abnormal impedance-pH test showed suboptimal contraction response as compared with those with normal impedance-pH test. Moreover, @entity1282 response was inversely correlated with AET and directly correlated with BI values and PSPW index.
