XXXX independence following isolated islet transplantation and single islet infusions.

@entity1 @entity6 @entity2690 @entity4053 @entity4854
OBJECTIVE: To restore islet function in @entity1 whose @entity6 subjected them to frequent dangerous episodes of hypoglycemic unawareness, and to determine whether multiple transplants are always required to achieve @entity2690 independence. SUMMARY BACKGROUND DATA: The recent report by the Edmonton group documenting restoration of @entity2690 independence by islet transplantation in seven consecutive @entity1 with type 1 @entity6 differed from previous worldwide experience of only sporadic success. In the Edmonton @entity1 , the transplanted islet mass critical for success was approximately more than 9,000 IEq/kg of recipient body weight and required two or three separate transplants of islets isolated from two to four cadaveric donors. Whether the success of the Edmonton group can be recapitulated by others, and whether repeated transplants using multiple donors will be a universal requirement for success have not been reported. METHODS: The authors report their treatment with islet transplantation of nine @entity1 whose labile type 1 @entity6 was characterized by frequent episodes of @entity4053 . RESULTS: In each of the seven @entity1 who have completed the treatment protocol (i.e., one or if necessary a second islet transplant), @entity2690 independence has been achieved. In five of the seven @entity1 only a single infusion of islets was required. To date, only one recipient has subsequently lost graft function, after an initially successful transplant. This @entity1 suffered recurrent @entity4854 9 months after the transplant. CONCLUSIONS: This report confirms the efficacy of the Edmonton immunosuppressive regimen and indicates that @entity2690 independence can often be achieved by a single transplant of sufficient islet mass.
