@entity407 promotes XXXX potential of bone marrow cells ex vivo.

@entity407 @entity1748 @entity9334 @entity1 @entity8415 @entity19 @entity170 @entity5271 @entity79 @entity2527 @entity731
OBJECTIVE: @entity170 is associated epidemiologically with @entity731 and @entity407 . We previously found that atherogenic lipids regulate bone formation. To determine whether @entity407 also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control @entity19 . METHODS: Nonadherent marrow cells from @entity1748 ( @entity1748 -/-)and C57BL/6J @entity19 were cultured with M-CSF and ligand for receptor activator of nuclear factor-kappaB ( @entity5271 ). Functional @entity2527 activity, measured as number of resorption pits, was significantly greater in 12-month-old @entity1748 -/-. Similar results were obtained in 5- and 10-month-old @entity1748 -/- versus C57BL/6J @entity19 on a high-fat diet. Osteoclastic differentiation, indicated by @entity9334 ( @entity9334 ) activity, was significantly greater in the 12-month-old @entity1748 -/-, and there was a trend toward increased @entity9334 activity in @entity1748 -/- on a high-fat diet, at ages 5 and 10 months. Osteoclastic parameters correlated with total serum lipoproteins with a possible threshold effect. Osteoporotic @entity1 cortical bone stained positive for lipids in the perivascular space of Haversian canals by oil red O. The presence of lipid @entity8415 was detected in bone marrow from hyperlipidemic @entity19 . CONCLUSIONS: @entity407 may contribute to @entity170 via @entity79 .
