Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal XXXX : The SHAPE-2 Randomised Controlled Trial.

@entity1 @entity0 @entity353 @entity28
INTRODUCTION: This study investigates the effect of a modest @entity353 either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to- @entity28 and inactive postmenopausal @entity1 . We hypothesize that HRQoL improves with @entity353 , and that exercise-induced @entity353 is more effective for this than diet-induced @entity353 . METHODS: The SHAPE-2 trial was primarily designed to evaluate any additional effect of @entity353 by exercise compared with a comparable amount of @entity353 by diet on biomarkers relevant for @entity0 risk. In the present analysis we focus on HRQoL. We randomly assigned 243 eligible @entity1 to a diet (n = 97), exercise (n = 98), or control group (n = 48). Both interventions aimed for 5-6 kg @entity353 . HRQoL was measured at baseline and after 16 weeks by the SF-36 questionnaire. RESULTS: Data of 214 @entity1 were available for analysis. Weight loss was 4.9 kg (6.1%) and 5.5 kg (6.9%) with diet and exercise, respectively. Scores of the SF-36 domain 'health change' increased significantly by 8.8 points (95% CI 1.6;16.1) with diet, and by 20.5 points (95% CI 13.2;27.7) with exercise when compared with control. Direct comparison of diet and exercise showed a statistically significantly stronger improvement with exercise. Both intervention groups showed a tendency towards improvements in most other domains, which were more pronounced in the exercise group, but not statistically different from control or each other. CONCLUSION: In a randomized trial in overweight-to- @entity28 and inactive postmenopausal @entity1 a comparable 6%-7% @entity353 was achieved by diet-only or mainly by exercise and showed improvements in physical and mental HRQoL domains, but results were not statistically significant in either the diet or exercise group. However, a modest @entity353 does lead to a positive change in self-perceived health status. This effect was significantly larger with exercise-induced @entity353 than with comparable diet-induced @entity353 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01511276.
