XXXX affects @entity19 olfactory mucosa gene expression and attenuates genes related to neurite outgrowth.

@entity1 @entity32 @entity9170 @entity19 @entity619
BACKGROUND: Olfaction is one of the important senses for @entity1 . Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a global view of the effect of systematic glucocorticoid treatment on gene expression in the olfactory mucosa (OM), we profiled these changes in a @entity19 model of olfaction in order to identify underlying molecular mechanisms. METHODS: C57BL/6 @entity19 were injected daily for 2 weeks (WK2) with @entity619 ( @entity9170 , intraperitoneally, 1 mg/kg body weight) vs 1 day of @entity9170 (D1) vs controls, which received saline (Ctrl) (n = 9/group). Total RNA from the OM was used to analyze global gene expression. Genes showing changes in expression were compared using the Database for Annotation, Visualization and Integrated Discovery (DAVID, v6.7) and the General Olfactory Sensitivity Database (GOSdb; http://genome.weizmann.ac.il/GOSdb). RESULTS: Between the WK2 and Ctrl groups, 3351 genes were differentially expressed, of which 236 genes were related to olfactory function. Genes involved in axon guidance, cell projection, and @entity32 were enriched and overlapped significantly with those in the GOSdb. CONCLUSION: Systemic glucocorticoids exert effects on transcription of a notable number of genes in the OM and appear to orchestrate changes related to axon guidance, cell projection, and @entity32 . Further examination may allow targeted therapies that lack the side effects of this category of medication.
