Aromatase activity and XXXX production by normal and malignant breast tissues.

@entity172 @entity650 @entity1 @entity32 @entity0 @entity5 @entity1346 @entity1815 @entity2671
The aromatase enzyme complex, which regulates the conversion of @entity2671 to @entity1815 , may have an important role in regulating @entity172 synthesis in breast tissues. In this study the effect of @entity5 location on aromatase activity in adjacent tissue was examined and related to @entity650 ( @entity650 ) production, which has been shown to stimulate aromatase activity in @entity0 cells. Samples of normal and malignant breast tissues were obtained from 11 @entity1 undergoing mastectomy. In 7 @entity1 , aromatase activity was highest in the quadrant in which the @entity5 was located or on which the @entity5 impinged. Aromatase activity in @entity5 -bearing quadrants was significantly higher than that in adjacent and opposite quadrants. Aromatase activity and @entity650 production, expressed in terms of tissue weight, were significantly higher for @entity5 tissue compared with normal breast adipose tissue. A significant correlation was found between aromatase activity and @entity650 production for @entity0 tissue (rs = 0.56; P < 0.05), but not for adipose tissue from the breast quadrants. Aromatase activity and @entity650 production were also measured in tissue obtained from a normal @entity1 undergoing reduction mammoplasty who had previously had breast augmentation by @entity1346 injection, not contained within a capsule. In tissue from this @entity1 there was evidence of @entity32 and a marked macrophage response. Aromatase activity in this tissue was considerably higher than that detected in mastectomy adipose tissue samples, and a significant correlation was found between aromatase activity and @entity650 production (rs = 0.77; P < 0.05). A preliminary study to examine the potential role of cells of the immune system in regulating breast tissue aromatase activity revealed that conditioned medium collected from macrophages and lymphocytes could markedly stimulate aromatase activity in @entity5 -derived fibroblasts. The results of this study confirmed that @entity0 location can influence aromatase activity in adjacent tissues and showed that aromatase activity is increased in @entity5 -bearing quadrants. The increased production of @entity650 by @entity5 tissue and its correlation with aromatase activity suggest that @entity5 may be the major source of @entity650 , which is able to influence aromatase activity in adjacent tissues.
