Protection against alcohol-induced gastric mucosal injury by XXXX : effect of @entity3352 .

@entity13736 @entity39 @entity2918 @entity13737 @entity35 @entity3352 @entity1718 @entity1068 @entity3737
The mechanism of gastric mucosal protection by an antiulcer agent, @entity13736 ( @entity13737 ), against @entity1068 -induced injury was investigated. The experiments were conducted with groups of @entity35 with and without intraperitoneal @entity3352 pretreatment. Animals received intragastrically either a dose of @entity13737 (200 mg/kg) or a vehicle, followed 30 min later by 1 ml of absolute @entity1068 . The @entity35 were sacrificed after 30 min and the gastric mucosa was subjected to macroscopic and histologic assessment and the measurements of adherent mucus, its dimension and chemical composition. In the absence of @entity13737 , @entity1068 produced advanced macroscopic @entity39 (greater than 38%) and the extensive @entity39 were visible upon histologic examination. Pretreatment with @entity13737 significantly reduced (p less than 0.001) the extent and depth of mucosal @entity39 caused by @entity1068 , and this protection was not thwarted by @entity3352 . Evaluation of the adherent mucus and its dimension by @entity3737 uptake and inverted microscope technique revealed that @entity13737 was also capable of preventing the untoward effect of @entity3352 on the adherent gastric mucus gel and its thickness. Results of chemical analyses established that in the absence of @entity13737 @entity3352 caused an increase in mucus protein (15%) and a decrease in its covalently bound @entity1718 (67%) and lipids (36%). The decrease in lipids was particularly reflected in the content of phospholipids. @entity3352 , however, had no apparent effect on the composition of gastric mucus elaborated in the presence of @entity13737 . The results suggest that gastric mucosal protective action of @entity13737 is not mediated by endogenous @entity2918 but rather appears to involve the metabolism of mucosal lipids.
