Evidence of increased brain amyloid in severe XXXX survivors at 1, 12, and 24 months after injury: report of 2 cases.

@entity1 @entity131 @entity64 @entity527 @entity31043 @entity2204 @entity73 @entity1188 @entity1613 @entity195 @entity29786 @entity130
UNASSIGNED: @entity131 ( @entity131 ) is a major risk factor for @entity195 . With respect to @entity527 , there are no published serial data regarding the deposition rate of amyloid throughout the brain after @entity131 . The authors conducted serial @entity31043 (florbetapir @entity29786 ) positron emission tomography (PET) imaging in 2 @entity1 with severe @entity131 at 1, 12, and 24 months after injury. A total of 12 brain regions were surveyed for changes in amyloid levels. Case 1 involved a 50-year-old @entity1 who experienced a severe @entity131 . Compared with the 1-month time point, of the 12 brain regions that were surveyed, a decrease in amyloid (as indicated by standard uptake value ratios) was only observed in the hippocampus (-16%, left; -12%, right) and caudate nucleus (-18%, left; -18%, right), suggesting that @entity1613 in the brain was cleared between time points 1 and 12 months after injury. Compared to the scan at 1 year, a greater increase in amyloid (+15%) was observed in the right hippocampus at the 24-month time point. The @entity1 in Case 2 was a 37-year-old @entity1 who suffered severe @entity130 to the head and a subsequent @entity64 ; he had poor cognitive/functional outcomes and underwent 1.5 years of rehabilitation. Due to a large @entity1188 area on the injured side of the brain (right side), the authors focused primarily on brain regions affected within the left hemisphere. Compared with the 1-month scan, they only found an increase in brain amyloid within the left anterior putamen (+11%) at 12 months after injury. In contrast, decreased amyloid burden was detected in the left caudate nucleus (-48%), occipital cortex (-21%), and precuneus (-19%) brain regions at the 12-month time point, which is indicative of early accumulation and subsequent clearance. In comparison with 12-month values, more clearance was observed, since a reduction in amyloid was found at 24 months after @entity130 within the left anterior putamen (-12%) and occipital cortex (-15%). Also, by 24 months, most of the amyloid had been cleared and the @entity1 demonstrated improved results on the Rivermead symptom questionnaire, Glasgow Outcome Scale-Extended, and Disability Rating Scale. With respect to @entity2204 status, the @entity1 in Case 1 had two   3 alleles and the @entity1 in Case 2 had one   2 and one   3 allele. In comparison to the findings of the initial scan at 1 month after @entity131 , by 12 and 24 months after injury amyloid was cleared in some brain regions and increased in others. Serial imaging conducted here suggests that florbetapir @entity29786 PET imaging may be useful in monitoring amyloid dynamics within specific brain regions following severe @entity131 and may be predictive of @entity73 .
