Different @entity3546 immunoexpression in XXXX of the appendix in comparison to other gastrointestinal carcinoid tumors.

@entity2466 @entity5 @entity5962 @entity3546 @entity876 @entity4303 @entity46182
@entity5 of the appendix is an endocrine @entity5 that is histologically similar to, but biologically less aggressive than @entity4303 arising from other parts of the gastrointestinal tract. In this study, we examined @entity5962 , @entity3546 , @entity46182 , @entity876 and Ki67 immunoexpression in cases of @entity2466 and made a comparison with non- @entity2466 tumors. Nine cases of @entity2466 and 11 biopsies of @entity4303 of other parts of the gastrointestinal tract, five cases of the small intestine and six of the stomach were immunohistochemically evaluated for Ki67, @entity876 , @entity46182 , @entity5962 and @entity3546 . Two main patterns of @entity3546 staining were observed. The first pattern was characterized as membranous and cytoplasmic, and was seen mainly in the peripheral cells of the nests. The second pattern was diffuse, predominantly membranous. Most (five of seven) @entity2466 and only three of 11 non-appendiceal cases showed the first staining pattern (p < 0.05). Immunoexpression of @entity5962 and @entity46182 was similar in both groups. @entity876 and Ki-67 immunostaining revealed stronger nuclear positivity in the non- @entity2466 tumors (statistically not significant). We found a pattern of @entity3546 immunostaining in typical @entity5 of the appendix that was different from the pattern seen in non- @entity2466 tumors. This alteration suggests that @entity2466 may represent a different subtype of @entity5 with different immunohistochemical and biological behavior.
