Combined steroid- XXXX treatment of chronic @entity792 . Clinical results and assessment of nephrotoxicity by renal biopsy.

@entity1 @entity644 @entity8 @entity137 @entity1333 @entity1252 @entity7255 @entity205 @entity230 @entity1499 @entity631 @entity792 @entity309
Twenty-one @entity1 suffering from different @entity792 (14 from @entity1252 , 4 from @entity309 , one from Sj  gren's syndrome, one from systemic @entity7255 , and one from @entity631 ) were treated with a combined immuno-suppressive regimen. @entity205 was given at a dose of 5 mg/kg/day together with @entity230 . In addition, the @entity309 @entity1 also received @entity1499 . In all @entity1 a kidney biopsy was performed after a treatment period of 17 to 42 months (mean duration 21.7 months). The cumulative @entity205 dose at the time of biopsy varied from 1.071 to 4.587 mg/kg. @entity1 suffering from @entity1252 and @entity309 were assessed according to a scoring system set up for this purpose. The combined therapy proved useful in these @entity1 as reflected in the diminution of the respective activity scores, improvement of kidney function, and diminution of @entity644 . Histological examination of the kidney biopsy specimens showed only minimal activity in @entity1 with @entity1252 . No unequivocal signs of @entity8 could be detected. In the last group, the condition of the @entity1 with Sj  gren's syndrome was stabilized and the @entity1 with systemic @entity1333 improved clinically. Neither @entity1 had signs of @entity8 . The @entity1 with @entity631 , in whom kidney biopsy was performed before and after treatment, showed improvement of kidney function, diminution of @entity644 , and diminution of inflammatory activity within the kidney, and no signs of @entity205 @entity137 .
