Orthotopic liver transplantation in XXXX : a single-center experience.

@entity1 @entity1071 @entity509 @entity292 @entity2876 @entity715 @entity850
INTRODUCTION: @entity2876 ( @entity2876 ) is the leading indication for orthotopic liver transplantation (OLT) among @entity1 . However, there are technical difficulties, including the limited dimensions of anatomical structures, @entity509 and/or @entity715 of the portal vein and previous portoenterostomy procedures. OBJECTIVE: The objective of this study was to present our experience of 239 @entity1 with @entity2876 who underwent OLT between September 1989 and June 2010 compared with OLT performed for other causes. METHODS: We performed a retrospective analysis of @entity1 charts and analysis of complications and survival. RESULTS: @entity2876 was the most common indication for OLT (207/409; 50.6%). The median age of subjects was 26 months (range, 7-192). Their median weight was 11 kg (range, 5-63) with 110 @entity1 (53.1%) weighing  <=10 kg. We performed 126 transplantations from cadaveric donors (60.8%) and 81 from living-related donors (LRD) (39.2%). Retransplantation was required for 31 recipients (14.9%), primarily due to @entity715 ( @entity715 ; 64.5%). Other complications included the following: @entity715 ( @entity715 ; 13.0%), @entity850 and/or @entity292 (22.2%), bowel perforation (7.0%), and @entity1071 ( @entity1071 ; 5.3%). Among the cases of OLT for other causes, the median age of recipients was 81 months (range, 11-17 years), which was higher than that for @entity1 with @entity2876 . Retransplantation was required in 3.5% of these @entity1 (P < .05), mostly due to @entity715 . The incidences of @entity715 , and @entity1071 were significantly lower (P < .05). There was no significant difference between biliary complications in the 2 groups. The overall survival rates at 1 versus 5 years were 79.7% versus 68.1% for @entity2876 , and 81.2% versus 75.7% for other causes, respectively. CONCLUSIONS: @entity1 who undergo OLT for @entity2876 are younger than those engrafted for other causes, displaying a higher risk of complications and retransplantations.
