[Immunocytochemical detection of @entity5 cells in bone marrow as a prognostic factor in XXXX ].

@entity1 @entity0 @entity5 @entity189 @entity3 @entity236
In a prospective study at the University of Erlangen, Dept. Gynaecol, and Obstet., 228 @entity1 with @entity0 during their primary surgery and 20 @entity1 during their metastatic surgery, underwent bone marrow punctions at six punction sides, which were twice at the sternum and twice at both iliac crest. The control group was 20 @entity1 without an @entity189 . Aim of the study was to detect or exclude @entity5 cells in the bone marrow via examination of the biopsies with monoclonal antibodies EMA and cytokeratin and consequently to find out the meaning of the results as prognostic criteria by statistical measurements. @entity5 cells in the bone marrow were detected in 46.5% (106/228) of the @entity1 , who underwent a bone marrow biopsy during primary surgery. 21% (23/106) of the @entity1 who were bone marrow positive, but only 5.75% (7/122) of the @entity1 , who were bone marrow negative, developed @entity3 during a median follow-up of 20 months. This difference is statistically significant. 17 of the 30 @entity1 with recurrences developed bone @entity3 ; 16 of them were EMA-positive. The median recurrence-free interval was 5 months in the bone marrow positive group and therefore noticeably shorter, than in the bone marrow negative @entity1 group with 11 months. Of the nodal negative @entity1 , 2 bone marrow positive @entity1 developed distant @entity3 . With the knowledge of the nodal status and bone marrow biopsy result, it was possible to predict 28 of the 30 @entity1 correctly in respect of their risk to metastasize. The result of the @entity236 was proved in a multivariate analysis to be an independent prognostic factor.(ABSTRACT TRUNCATED AT 250 WORDS)
