XXXX enhances early postoperative contractility of the denervated @entity1819 as an esophageal substitute.

@entity1 @entity2929 @entity1819
OBJECTIVE: To determine whether early postoperative administration of @entity2929 accelerates the spontaneous motor recovery process after elevation of the denervated @entity1819 up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: @entity2929 was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten @entity1819 ( @entity1819 ) @entity1 at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 @entity1819 @entity1 , followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 @entity1 , in 23 @entity1819 @entity1 not receiving @entity2929 , and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of @entity2929 at and after surgery was significantly higher than that without @entity2929 (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in @entity1819 @entity1 with >3 years of follow-up who never received @entity2929 (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four @entity1 who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three @entity1 . CONCLUSIONS: Early postoperative contractility of the denervated @entity1819 pulled up to the neck under either i.v. or oral @entity2929 is similar to that recovered spontaneously beyond 3 years of follow-up. In some @entity1 , this booster effect persists after discontinuation of the drug.
