Pharmacological management of XXXX .

@entity1 @entity350 @entity101 @entity6 @entity28 @entity5 @entity352 @entity164 @entity74 @entity750 @entity340 @entity1063 @entity65
Obesity is a major chronic health problem in adults. It is a complex, @entity74 characterised by excess accumulation of adipose tissue. It is associated with a number of complications including @entity65 , @entity101 , @entity164 2 @entity6 , dyslipidaemia and @entity5 . A weight loss in the order of 5-10% is associated with clinically meaningful reductions with respect to all comorbidities. Diet and exercise has been the cornerstone of weight management therapy, but this approach has limitations, especially for weight maintenance. Previous drugs used in @entity28 had serious side effects including @entity340 . However, recent drugs like @entity350 and @entity352 have been rigorously tested and proven safe. @entity350 , a lipase inhibitor, inhibits absorption of dietary fat by approximately 30%. Taken with a hypocaloric diet, it produces and maintains clinically meaningful weight loss. @entity352 is a centrally-acting agent which enhances satiety and thermogenesis by inhibiting @entity750 and @entity1063 re-uptake. It is appropriate for @entity1 who are unable to lose weight by lifestyle modification.
