Cumulative incidence of radiation-induced cavernomas in long-term survivors of XXXX .

@entity1 @entity2270 @entity2946 @entity548
OBJECT: The goal of this study was to determine the incidence of radiation-induced cavernomas in @entity1 treated for @entity2946 . METHODS: A retrospective chart and film review was performed for all @entity1 treated for @entity2946 at the Insitute for Neurology and Neurosurgery/Beth Israel Medical Center between August 1996 and the present. The clinical and radiographic histories of pediatric @entity1 (ages 3-21 years at diagnosis) with a histologically confirmed diagnosis of @entity2946 who received craniospinal radiation therapy were reviewed. Fifty-nine @entity1 were identified, with a mean age at radiation treatment of 7.7 years and a mean follow-up time of 7.2 years. The dose to the @entity2270 was 24 Gy (31 @entity1 ) or 36 Gy (28 @entity1 ). The radiation energy in the @entity2270 was provided by photons in 55 @entity1 and protons in four. All @entity1 received a posterior fossa boost of 54 Gy (46 @entity1 ) or 72 Gy (13 @entity1 ). Twenty-six lesions developed in 18 @entity1 (31%) during the observation period. The cumulative incidence of lesion development was 5.6, 14, and 43%, at 3, 5, and 10 years, respectively. The sites of occurrence were cerebral (20 cases) and cerebellar (six cases). There was no significant correlation between age at diagnosis, sex, craniospinal radiation dose or energy source, and lesion development. Only one @entity1 required surgical intervention for a symptomatic @entity548 in the frontal lobe. Histological analysis in this case was consistent with cavernoma. CONCLUSIONS: Cavernomas are common after cranial irradiation in @entity1 , and their incidence increases over time. Most of these lesions follow a benign course and do not require intervention.
