Clinical characteristics and outcomes from an institutional series of acinar cell XXXX .

@entity1 @entity788 @entity66 @entity1124 @entity146 @entity5 @entity3981 @entity3
PURPOSE: @entity3981 is a rare @entity5 . Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest retrospective review to date. @entity1 AND METHODS: Thirty-nine @entity1 with pathologically confirmed acinar neoplasms of the pancreas were identified between August 1981 and January 2001. Demographic data, @entity5 characteristics, and treatment information were obtained by chart review. Survival probabilities were estimated by using the Kaplan-Meier method and compared using the log-rank test. RESULTS: The median survival for all @entity1 was 19 months. On the basis of a univariate analysis, the @entity1 ' stage of disease correlated significantly with survival. The median survival of @entity1 with @entity66 was 38 months, versus 14 months for those presenting with @entity3 (P = 0.03). @entity1 who could be treated with surgery as first-line therapy had a longer survival time (36 months) compared with those who did not have surgery (14 months). Two of 18 @entity1 who received chemotherapy and three of eight @entity1 who received radiation had a major response. CONCLUSION: The survival curves suggest a more @entity146 @entity5 than @entity788 but one that is less @entity146 than @entity1124 . Those @entity1 who present with @entity66 have a much better prognosis than those who present with @entity3 . There is a high recurrence rate after complete surgical resection, suggesting that micrometastases are present even in @entity66 and that adjuvant therapies may be indicated. Chemotherapy and radiation afford disappointing results, however, and novel therapies are needed.
