Bone mineral density and XXXX : data from the Baltimore Longitudinal Study of Aging.

@entity1 @entity79 @entity604 @entity571
BACKGROUND: Numerous cross-sectional studies have shown that @entity1 with radiographic features of @entity571 ( @entity571 ) of the hips and knees have higher adjusted levels of @entity79 ( @entity79 ). OBJECTIVE: Data from the Baltimore Longitudinal Study of Aging were examined to determine (1) whether @entity1 with radiographic features of @entity571 of the hands and knees had different rates of @entity604 than subjects with normal knee radiographs, and (2) whether @entity1 with normal knee radiographs who had higher adjusted levels of @entity79 were at greater risk of developing radiographic features of knee @entity571 . DESIGN: Longitudinal cohort study. SUBJECTS: 298 Caucasian @entity1 and 139 Caucasian @entity1 aged 20 and above who had radiographs of the hands and knees read for features of @entity571 and two or more measurements of @entity79 at the forearm at least 4 years apart. 179 Caucasian @entity1 and 110 Caucasian @entity1 aged 20 and above who had longitudinal knee radiographs on average 10 years apart, a subgroup of whom had baseline measurement of lumbar spine and/or femoral neck @entity79 . RESULTS: @entity1 with radiographic @entity571 of the hand had a significantly greater adjusted rate of @entity604 at the radius than @entity1 with normal hand radiographs; no such differences were noted in @entity1 for hand @entity571 . There were no significant differences in adjusted rate of @entity604 at the radius in @entity1 or @entity1 by presence of radiographic knee @entity571 . Higher @entity79 at the lumbar spine but not at the femoral neck was associated with an increased risk of developing incident radiographic knee @entity571 after adjustment for age, gender, and body mass index. CONCLUSIONS: These data demonstrate that @entity1 with radiographic @entity571 lose bone at different rates than those with normal radiographs and that this relationship varies between the site of @entity571 and the site of measurement of @entity79 . In addition, they further support a role for higher bone mass in the development of radiographic knee @entity571 . Further studies are needed to examine the relationship between changes in bone mass and radiographic progression of @entity571 .
