A practical, comprehensive classification for pediatric XXXX : the CCC system.

@entity1 @entity12188 @entity6130 @entity2590 @entity102 @entity1503 @entity74
PURPOSE: Pediatric @entity2590 ( @entity2590 ) are biologically diverse. The French-American-British (FAB) classification of adult forms of @entity2590 is not always applicable because many pediatric @entity1 do not fit into any of the categories. To circumvent the FAB schema and other flawed formats, the authors developed a practical classification system for childhood @entity2590 . @entity1 AND METHODS: The authors analyzed 40 @entity1 with @entity2590 diagnosed in Toronto between 1988 and 1998 to test the utility of the classification. @entity1 were classified according to three main features: category, cytology, and cytogenetics. RESULTS: Using this system the authors were able to classify all 40 @entity1 ; about half could not be unclassified by FAB. @entity1 could also be longitudinally classified by serial analysis to show @entity74 . @entity12188 was excluded because of its known myeloproliferative pathogenesis. @entity6130 , which almost never occurs in @entity1 , was also omitted. Also excluded were other @entity102 and any @entity1503 without malignant potential. CONCLUSIONS: Based on these data, the CCC system appears to have prognostic potential; @entity1 with advanced class and cytogenetic abnormalities had a poorer outcome. The authors urge international adoption of this system for uniformity in clinical practice and reporting purposes.
