Mesh fixation methods in open XXXX : a protocol for network meta-analysis and trial sequential analysis of randomised controlled trials.

@entity1 @entity158 @entity547 @entity169 @entity282 @entity922
INTRODUCTION: @entity922 ( @entity922 ) have been used to compare and evaluate different types of mesh fixation usually employed to repair open @entity169 . However, there is no consensus among surgeons on the best type of mesh fixation method to obtain optimal results. The choice often depends on surgeons' personal preference. This study aims to compare different types of mesh fixation methods to repair open @entity169 and their role in the incidences of chronic @entity158 , risk of @entity547 recurrence, complications, operative time, length of hospital stay and @entity282 , using Bayesian network meta-analysis and trial sequential analysis of @entity922 . METHODS AND ANALYSIS: A systematic search will be performed using PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM) and Chinese Journal Full-text Database, to include @entity922 of different mesh fixation methods (or fixation vs no fixation) during open @entity169 . The risk of bias in included @entity922 will be evaluated according to the Cochrane Handbook V.5.1.0. Standard pairwise meta-analysis, trial sequential analysis and Bayesian network meta-analysis will be performed to compare the efficacy of different mesh fixation methods. ETHICS AND DISSEMINATION: Ethical approval and @entity1 consent are not required since this study is a meta-analysis based on published studies. The results of this network meta-analysis and trial sequential analysis will be submitted to a peer-reviewed journal for publication. PROTOCOL REGISTRATION NUMBER: PROSPERO CRD42015023758.
