Use of @entity5646 in the treatment of serious XXXX due to multiresistant gram-negative organisms, including @entity796 .

@entity1 @entity5503 @entity801 @entity7048 @entity796 @entity55 @entity4028 @entity4034 @entity7911 @entity793 @entity281 @entity1398 @entity3398 @entity358 @entity869 @entity2259 @entity5646
@entity5646 is a novel antimicrobial agent belonging to the monobactam class of antibiotics. It inhibits both beta-lactamase-producing and non-beta-lactamase-producing aerobic gram-negative bacilli, but it has no activity against gram-positive species or against anaerobic species. The efficacy of @entity5646 in the treatment of @entity281 in 76 @entity1 and its safety in 87 @entity1 was evaluated. The majority (91 percent) of @entity1 had significant underlying disease, and 47 percent were critically ill. @entity5646 produced an overall clinical response of 86 percent, with 10 of 11 cases of @entity2259 cured, including four due to @entity796 , seven of eight cases of @entity55 , and seven of nine episodes of @entity4034 . Infections due to bacteria resistant to @entity869 , @entity7911 , @entity7048 , @entity5503 , @entity3398 , and @entity801 were cured. Although 15 of 18 @entity1 with exacerbations of @entity358 due to @entity796 showed clinical improvement, bacteriologic cure was not achieved, as has been noted with other drugs. Similarly, @entity1 with major underlying structural abnormalities of the urinary tract showed early relapses of @entity793 . @entity5646 combined with antistaphylococcal, antistreptococcal, or antianaerobic agents provided an alternative to @entity4028 use in these non- @entity1398 @entity1 . Administration of 1 or 2 g every eight hours yield serum bactericidal levels well in excess of 1:8 against all Enterobacteriaceae and some @entity796 strains. There was a low incidence of adverse side effects, none serious. Overall, @entity5646 is a useful alternative to the drugs available for use in hospital-acquired gram-negative @entity281 and provides a chance for more directed therapy.
