The @entity995 protein/ @entity986 XXXX pathway but not @entity876 is disrupted by @entity1082 in @entity957 .

@entity986 @entity5 @entity1083 @entity957 @entity3544 @entity876 @entity1799 @entity1082 @entity105 @entity995
AIMS: The pathogenesis of @entity957 ( @entity957 ) is not well understood. @entity1082 ) may be involved in @entity105 , but few studies have compared cell-cycle protein expression in @entity5 . The aim was to determine the extent of @entity1083 in different histological subtypes of @entity957 and its impact on the expression of key cell-cycle proteins: @entity876 , @entity3544 , @entity986 ( @entity986 ) and @entity995 ( @entity995 ) protein. METHODS AND RESULTS: One hundred and forty-eight @entity957 samples were examined immunohistochemically for @entity995 , @entity986 ( @entity986 ) , @entity876 and @entity3544 protein expression. One hundred and two cases were typed for HPV by PCR. HPV DNA was detected in 56% of @entity5 , with @entity1799 present in 81%. @entity5 were related strongly to @entity1083 (10 of 13), while verrucous were not (three of 13). Fifty-nine per cent (38 of 64) of usual type SCCs had @entity1083 . @entity995 protein correlated negatively (P<0.0001) and @entity986 ( @entity986 ) (P<0.0001) and @entity3544 (P=0.0002) correlated positively with @entity1083 . @entity876 did not correlate with @entity1083 . CONCLUSIONS: @entity1083 is present in more than half of @entity5 and it is responsible for @entity995 pathway disruption. However, no link between HPV and @entity876 immunodetection was found. Only basaloid and half of usual-type PSSCs correlate with @entity1083 , confirming possible separate aetiologies for those @entity5 .
