Inflammation-sensitive plasma proteins and incidence of @entity583 in XXXX with low cardiovascular risk.

@entity1 @entity32 @entity2002 @entity2104 @entity583
OBJECTIVE: @entity583 ( @entity583 ) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of @entity583 in nonsmoking, nondiabetic @entity1 with normal blood pressure and serum lipids is related to @entity32 ( @entity32 ). METHODS AND RESULTS: Five @entity32 (alpha1-antitrypsin, @entity2104 , ceruloplasmin, @entity2002 , orosomucoid) were analyzed in 6075 @entity1 , 47+/-3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (> or =2 major risk factors, n=1011) were defined. Incidence of @entity583 (n=227) was monitored over 18.1+/-4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for @entity1 with 0, 1, 2 and > or =3 @entity32 in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after > or =10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for @entity1 with 0, 1, 2, and > or =3 @entity32 in the top quartile (trend: P=0.0004). CONCLUSIONS: Incidence of @entity583 in nonsmoking, nondiabetic @entity1 with normal blood pressure and lipids was related to @entity32 . The causes for this relationship remain to be explored.
