Regulation of XXXX synthesis during adipogenesis in males of a vespertilionid bat, Scotophilus heathi.

@entity1243 @entity1386 @entity8277 @entity42435 @entity2368 @entity413
The aim of this study was to elucidate the hormonal regulation of @entity1243 synthesis by the @entity1386 ( @entity1386 ) during the period of fat accumulation in male Scotophilus heathi. An in vivo study showed a significant correlation between the seasonal changes in serum insulin level with the circulating @entity1243 level and with the changes in body fat mass in S. heathi. An in vitro study showed insulin induced a significant increase in expression of @entity1243 protein in @entity1386 . The insulin-stimulated increase in @entity1243 expression was associated with increased uptake of @entity413 in the @entity1386 . Two @entity413 transporters ( @entity2368 and @entity42435 ) are utilized for transport of @entity413 in the @entity1386 during adipogenesis in the bat. The bats showed high insulin and @entity413 levels, but a reduction in @entity8277 protein during the period of fat deposition, suggesting insulin resistance, which improved in late winter (January) when most of the fat has been utilized as a metabolic fuel. The in vitro study confirmed that insulin enhanced @entity1243 and @entity2368 expression in @entity1386 . The in vitro study further showed that the expression of @entity1243 is directly proportional to the amount of @entity413 uptake by the @entity1386 . The expression of @entity2368 and @entity42435 were also shown to be differentially regulated by insulin during adipogenesis. The insulin-stimulated increase in @entity1243 synthesis by @entity1386 is mediated through phosphorylation of MAPK in S. heathi. The specific role of @entity2368 and @entity42435 in the regulation of @entity1243 synthesis during adipogenesis needs further investigation.
