Expression and prognostic significance of matrix metalloproteinases and their tissue inhibitors in primary XXXX of the skin.

@entity1552 @entity1 @entity3334 @entity8111 @entity1476 @entity5 @entity1549 @entity1550 @entity1551 @entity2843 @entity15976 @entity1495 @entity3270
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many @entity5 , but data for primary @entity3270 (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prognostic significance. Expression of @entity3334 , @entity1476 , @entity1549 , @entity1495 , @entity15976 , @entity1550 , and @entity1551 and @entity2843 , @entity1552 , and @entity8111 was evaluated by immunohistochemistry on 23 samples of PNC of the skin. The results were matched with clinical features and @entity1 survival. In the 23 specimens of PNC, high (>20% of positive neoplastic cells) @entity3334 expression was found in 13 (56.5%) cases. @entity1476 was evidenced in 12 (52.1%) cases, 8 (34.7%) of which showed high expression in neoplastic cells. @entity1549 was detected in 11 cases (47.8%), with high expression in 9 (39.1%) of them. High @entity1495 expression was observed in 3 (13%) cases, whereas high @entity1551 expression was detected in 11 (47.8%) specimens. Expression of @entity2843 by neoplastic cells was found in 8 (34.7%) cases, with high expression in 3 cases, whereas high @entity8111 expression was detected in 21 (91.3%) cases. No immunoreactivity for @entity15976 , @entity1550 , or @entity1552 was found. Statistical analysis failed to identify a significant correlation between MMP/ @entity2843 expression and clinical parameters. By univariate analysis, stage >I (P = 0.01), high expression of @entity3334 (P = 0.04) and @entity1549 (P = 0.01) resulted significant negative prognostic factors, whereas by multivariate analysis, stage was the only factor that affected survival (P = 0.02). Our results suggest that @entity3334 and @entity1549 may influence the invasive and metastatic potential of PNCs. It is conceivable that future attempts to specifically block @entity3334 and @entity1549 activity may provide a novel means to inhibit invasiveness and distant spread in selected @entity1 with PNC.
