Effects of Ixeris dentata water extract and XXXX on @entity32 in vivo and in vitro.

@entity1 @entity32 @entity483 @entity18580 @entity55 @entity5 @entity19 @entity39 @entity3806 @entity14627 @entity272 @entity99 @entity1909
BACKGROUND: Ixeris dentata Nakai has been used for the treatment of mithridatism, calculous, indigestion, @entity55 , @entity99 , and @entity5 in Korea, China, and Japan. However, the effect of a water extract of Ixeris dentata (ID) and its molecular mechanism on @entity32 has not been elucidated. In this study, we attempted to evaluate the effects of ID and its major compound @entity14627 on @entity32 in vivo and in vitro. METHODS: ID was applied to @entity18580 (DNFB)-induced @entity483 ( @entity483 )-like @entity272 @entity19 and immune cell infiltration, cytokine production, and the activation of mitogen-activated protein kinases (MAPKs) were investigated. Moreover, the effect of ID on compound 48/80-induced anaphylactic shock was investigated in a @entity19 model. The @entity1 keratinocyte cell line (HaCaT cells) and @entity1 mast cells (HMC-1) were treated with ID or @entity14627 to investigate the effects on the production of chemokines and proinflammatory cytokines and on the activation of MAPKs. RESULTS: ID inhibited the serum levels of IgE and interleukin (IL)-1b in DNFB-induced @entity483 -like @entity272 @entity19 models and suppressed anaphylactic shock in the @entity19 models. ID and @entity14627 inhibited the production of chemokines and adhesion molecules in HaCaT cells. In addition, ID reduced the release of @entity5 @entity39 factor-a and @entity3806 via the inhibition of MAPKs phosphorylation in HMC-1 cells. CONCLUSIONS: These results suggest that ID is a potential therapeutic agent for allergic inflammatory diseases, including @entity1909 .
