Cyclooxygenase-2 in XXXX pathological disease.

@entity1 @entity571 @entity731 @entity5 @entity75 @entity1313 @entity2339 @entity299 @entity9859 @entity2247 @entity1020
To understand the potential role of cyclooxygenase (COX) in normal and inflammatory @entity1 diseases, we characterized the expression of @entity9859 and @entity2247 in biopsies of @entity571 , @entity731 , and @entity5 . Tissues were prepared for immunohistochemistry by standard methods, and representative cases assayed via Western blot and quantitative RT-PCR. @entity2247 was not detected in normal @entity1 tissues with few exceptions. Moderate to marked @entity2247 was observed in the @entity1020 ( @entity1020 ) and thick ascending limb (TAL) in @entity1 fetal kidneys, but was not detected in neonatal and adult @entity1020 and TALs. Low level, constitutive @entity2247 was detected in colonic epithelium, peribronchial glands, and pancreatic ductal epithelium. Low to moderate @entity2247 was detected basally in the cortex, hippocampus, @entity2339 , and spinal cord, and in reproductive tissues during ovulation, implantation and labor. No @entity2247 was detected in the existing vasculature in normal tissues, and was also not expressed throughout the ductus arteriosus. @entity2247 was markedly induced in @entity1 tissues of @entity571 , @entity731 and @entity5 . @entity2247 was prominently expressed in the synovium, fibrocartilage of osteophytes, and in the blood vessels in the osteoarthritic (OA) knee joint. @entity2247 was also prominently detected in the macrophages/foam cells in @entity731 , and in the endothelium overlying and immediately adjacent to the @entity75 . Moderate- to intense @entity2247 expression was consistently observed in the inflammatory cells, @entity1313 , and blood vessels in all epithelial-derived @entity1 @entity5 studied. In contrast, @entity9859 was relatively ubiquitously observed in both normal and pathophysiological conditions. These data collectively imply @entity2247 plays an important role in mediating a variety of inflammatory diseases, and imply @entity2247 inhibitors may be effective in the prevention and/or treatment of OA, @entity299 , and @entity5 .
