Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and XXXX subjects.

@entity1 @entity1369 @entity101 @entity28 @entity13519 @entity413
BACKGROUND: Renal sinus fat (RSF) has been recognized as a risk factor for arterial @entity101 . This study was addressed to examine whether also para- and perirenal fat accumulation is associated to higher 24-h mean systolic ( @entity13519 ) and/or diastolic blood pressure (DBP) levels in overweight and @entity28 subjects. METHODS: A cohort of 42 overweight and @entity28 @entity1 , 29 @entity1 and 13 @entity1 , aged 25-55 years, not treated with any kind of drug, was examined. Body mass index (BMI), waist circumference (WC), fasting insulin and @entity413 serum levels, insulin resistance (assessed by using the homeostasis model assessment [HOMAIR]), and 24-h @entity1369 urine levels were measured. Ambulatory blood pressure monitoring (ABPM) was measured with 15  min intervals from 7.0  a.m. to 11.0  a.m. and with 30  min intervals from 23.0 to 7.0 for consecutive 24  h, starting from 8:30  AM. Measurement of para- and perirenal fat thickness was performed by ultrasounds by a duplex Doppler apparatus. RESULTS: Para- and perirenal ultrasonographic fat thickness (PUFT) was significantly and positively correlated with WC (p   <   0.01), insulin (p   <   0.01), HOMAIR (p   <   0.01), and 24-h mean DBP levels (p   <   0.05). 24-h mean DBP was also significantly and positively correlated with 24-h @entity1369 urine concentrations (p   <   0.001). A multivariate analysis by multiple linear regression was performed; the final model showed that the association of 24-h mean DBP as dependent variable with PUFT (multiple R   =   0.34; p   =   0.026) and daily @entity1369 production (multiple R   =   0.59; p = 0.001) was independent of other anthropometric, hormone and metabolic parameters. DISCUSSION AND CONCLUSIONS: This study shows a positive independent association between PUFT and mean 24-h diastolic blood pressure levels in overweight and @entity28 subjects, suggesting a possible direct role of PUFT in increasing daily diastolic blood pressure.
