Incompletely and completely healed duodenal XXXX ' outcome in maintenance treatment: a double blind controlled study.

@entity1 @entity4444 @entity1066 @entity4773 @entity446
A six month, double blind, controlled study was performed in 107 asymptomatic duodenal @entity1066 @entity1 who, after short term @entity4444 treatment, showed complete or incomplete @entity446 . @entity1 were stratified according to the type of healing and randomly allocated to @entity4444 (200 mg at lunch, 400 mg at bedtime) or placebo. Endoscopic examinations were carried out after six months or when symptoms recurred. Eighty seven @entity1 completed the maintenance trial. Of the 56 @entity1 admitted to the study with complete healing, 30 were placed on @entity4444 and 26 on placebo. Of the 31 @entity1 admitted with incomplete healing, 15 were placed on @entity4444 , and 16 on placebo. Results showed that, regardless of maintenance treatment, @entity1 with incompletely healed @entity1066 had a higher @entity1066 crater recurrence rate, than @entity1 with complete healing (71% vs 34%; p less than 0.005). A significantly higher @entity1066 crater recurrence was observed in incompletely healed @entity1066 @entity1 , even when @entity4444 or placebo treatment groups were considered separately. Irrespective of the type of healing, @entity1066 crater recurrence was more frequent in placebo treated @entity1 than in those treated with @entity4444 (67% vs 29%; p less than 0.001). We conclude that, in order to prevent a high @entity1066 recurrence rate, maintenance treatment should start only after the assessment of a complete @entity4773 .
