The @entity4105 gene polymorphism and @entity2998 in XXXX .

@entity1 @entity32 @entity16 @entity2998 @entity4105 @entity71494 @entity731 @entity543 @entity121 @entity454
BACKGROUND: @entity4105 is a cell surface glycoprotein that mediates the adhesion of leucocytes to vessels endothelium, an important early step in the @entity731 process. @entity454 ( @entity454 ) is a highly atherogenic disease but it is unknown whether genetic polymorphism(s) in the @entity4105 gene plays a role in the severity of @entity16 in this condition. Method. In this study, we tested whether the @entity71494 variant in the @entity4105 gene is linked to @entity2998 in 134 well-characterized @entity454 @entity1 . The frequency of this polymorphism was also measured in a population sample of the same geographical area. RESULTS: A total of 84% @entity1 had the CC genotype, 13% had the CT genotype, 3% had the TT genotype and this distribution did not differ from that in the control population. @entity121 ( @entity121 ) (P = 0.01) and cross-sectional area (P = 0.02) were significantly higher in @entity1 with the T-allele than in those without this allele. Furthermore, the degree of @entity543 was significantly higher (P = 0.02) in @entity1 with T-allele than in CC @entity1 . On multivariate analyses including the traditional and non-traditional risk factors, the @entity71494 polymorphism was confirmed as an independent correlate of @entity121 (P = 0.02), cross-sectional area (P = 0.03) and @entity543 (P = 0.02). CONCLUSION: In @entity454 , the @entity71494 polymorphism of @entity4105 gene is associated with the severity of @entity2998 , suggesting that genetically-determined alterations in the @entity4105 molecule may render @entity454 @entity1 with this gene variant particularly susceptible to the detrimental effects of @entity32 on the arterial wall.
