Alteration of hepatic XXXX metabolism after burn injury in @entity1707 .

@entity1707 @entity844 @entity99 @entity1718 @entity1285 @entity9931 @entity412 @entity158 @entity860 @entity6625 @entity130
BACKGROUND: The primary goal of this study was to investigate hepatic @entity844 (FA) metabolism after severe @entity130 . METHODS: Sixteen @entity1707 were divided into control (n = 8) and burn (n = 8, with 40% full thickness total body surface area burned) groups. Catheters were inserted in the right common carotid artery, portal vein, and hepatic vein for blood sampling. Flow probes were placed around the hepatic artery and portal vein for blood flow measurements. Animals were @entity158 medication and sedated until the tracer study on day 4 after burn. The @entity1707 were infused for 4 hours with U-13C16-palmitate in order to quantify hepatic FA kinetics and oxidation. RESULTS: Liver @entity412 (TG) content was elevated from 162 +/- 16 (control) to 297 +/- 28 micromol TG/g dry liver wt. (p < .05). Hepatic FA uptake and oxidation were similar between the 2 groups, as were @entity1285 ( @entity9931 ) levels and activities of @entity6625 carboxylase and @entity860 ( @entity860 )-activated protein kinase. In contrast, incorporation of plasma-free @entity1718 into @entity99 was elevated (p < .05) and very low density lipoprotein TG (VLDL-TG) secretion was decreased from 0.17 +/- 0.02 (control) to 0.03 +/- 0.01 micromol/kg per minute in burned @entity1707 (p < .05). CONCLUSIONS: The accumulation of @entity99 in burned animals is due to inhibition of VLDL-TG secretion and to @entity99 . @entity1718 are not channeled to TG because of impaired oxidation.
