Long-term @entity935 transporter imaging in XXXX treated with zona incerta stimulation.

@entity935 @entity1 @entity409 @entity191
OBJECTIVE: The caudal zona incerta (cZI) is a promising, clinically beneficial target for deep brain stimulation (DBS) in @entity191 ( @entity191 ). To assess whether DBS of the cZI affects the rate of @entity935 terminal dysfunction, @entity191 @entity1 with and without DBS were followed prospectively with I FP-Cit single photon emission tomography from the first diagnosis and up to 8 years. METHODS: Six @entity1 underwent DBS of the cZI during the survey period. Twenty-two @entity191 @entity1 only on pharmacotherapy served as controls. I FP-Cit and clinical assessment were performed at baseline and after 1, 3 and 5 years in all @entity1 . Ten @entity1 also underwent a I FP-Cit after 8 years. Image data were evaluated semiquantitatively. Mixed-model analysis was used to assess the relative change in I FP-Cit uptake and comparison between surgically and conservatively treated @entity191 @entity1 . RESULTS: The relative decrease in I FP-Cit uptake was more pronounced in DBS-treated @entity1 than in controls in the more affected caudate (P=0.037) and putamen (P=0.013). The annual decrease rates were higher in the less affected than the more affected putamen, and were slightly greater in DBS-treated @entity1 (4.8%, 95%confidence interval: 8.5-2.2%) than in controls (4.0%, 95% confidence interval: 5.1-3.1%). CONCLUSION: This long-term prospective study confirms that the underlying @entity409 continues despite clinical improvement in @entity191 @entity1 with DBS of the cZI. A slightly faster rate of decrease in I FP-Cit uptake in these @entity1 compared with conservatively treated @entity191 @entity1 may reflect a more aggressive form of @entity191 .
