Eotaxin in exhaled breath condensate of allergic asthma XXXX with exercise-induced bronchoconstriction.

@entity748 @entity565 @entity32 @entity1
BACKGROUND: Eosinophils are the key inflammatory cells in @entity565 , and more and more evidence suggests their crucial role in exercise-induced bronchoconstriction (EIB). Eotaxin, as the most important chemotactic factor for eosinophils, plays an important role in the pathogenesis of @entity565 . OBJECTIVES: The aim of the study was to evaluate the changes in eotaxin levels in exhaled breath condensate (EBC) following intensive exercise in allergic asthmatics. METHODS: The study was performed in a group of 27 asthmatics (17 with EIB, 13 without EIB) and 9 healthy volunteers. Changes induced by intensive exercise in the concentrations of eotaxin in EBC during the 24 h after an exercise test were assessed. The possible correlations of these measurements with the results of other tests commonly associated with @entity32 were also determined. RESULTS: In @entity748 @entity1 with EIB, a statistically significant increase in eotaxin concentrations in EBC collected during the first 24 h after an exercise test - with maximal increase after 6 h - was revealed. A statistically significant correlation between the maximum increase in eotaxin concentrations in EBC after exercise, and an increase in either serum eosinophil cationic protein or F(ENO) 24 h after exercise in the group of asthmatics with EIB, was observed. CONCLUSIONS: Our results confirm connections between EIB and airway eosinophilic @entity32 . The increase of eotaxin in @entity748 airways, by promoting the migration and activation of eosinophils, may play an important role in upregulation and sustaining of the airway @entity32 observed in EIB in @entity748 @entity1 .
