Identification of early environmental risk factors for XXXX and @entity2210 .

@entity1 @entity1902 @entity1744 @entity2210 @entity166
BACKGROUND: The role of childhood environment including exposure to infection via siblings and pets in @entity1744 ( @entity166 ) and @entity2210 is relatively unknown. We assessed proxy measures of microbial exposure in early childhood to assess if these are associated with @entity166 and functional @entity2210 in later life. METHODS: @entity1 (n  =  767, response rate  =  53%) were a random population sample from Sydney, Australia who previously responded to a validated survey. @entity166 and functional @entity2210 were defined using Rome III criteria. Early environmental risk factors assessed included type of birth delivery, premature birth, breastfeeding, bedroom sharing, and pet exposure (the latter two then combined as early hygiene factors) up to 5  years of age. Post infectious @entity166 ( @entity166 ) was assessed by development of @entity166 following @entity1902 . KEY RESULTS: In this sample, in adult life 17% developed @entity166 (of which 20% had @entity166 ) and 12% functional @entity2210 . Development of @entity166 was associated with childhood factors-a shorter duration of breastfeeding (odds ratios [OR]  =  0.87, 95% CI: 0.78-0.97, p  =  0.01), sharing a bedroom (OR  =  1.89, 95% CI: 1.73-3.08, p  =  0.01), exposure to a herbivore pet (OR  =  1.65 (1.10, 2.48), p  =  0.02), and hygiene factors (OR  =  4.39; 95% CI: 1.89-10.21, p  =  0.001). The sole factor associated with functional @entity2210 was exposure to a herbivore pet (1.79; 95% CI: 1.19-2.87, p  =  0.02). CONCLUSIONS _ INFERENCES: Childhood environment factors, particularly bedroom sharing and pet exposure, combined with subsequent risk of microbial exposure are a risk factor for @entity166 in later life. These associations however need confirmation to rule out any risk of a type I error.
