Neuroendocrine and metabolic effects of acute ghrelin administration in @entity1 XXXX .

@entity1 @entity28 @entity73 @entity701 @entity1943 @entity413 @entity774
Ghrelin stimulates appetite and plays a role in the neuroendocrine response to energy balance variations. Ghrelin levels are inversely associated with body mass index (BMI), increased by fasting and decreased by food intake, @entity413 load, insulin, and @entity1943 . Ghrelin levels are reduced in @entity28 , a condition of hyperinsulinism, reduced GH secretion, and @entity774 hyperactivity. We studied the endocrine and metabolic response to acute ghrelin administration (1.0 microg/kg i.v.) in nine obese @entity1 [OB; BMI (mean +/- SD) 36.3 +/- 2.3 kg/m(2)] and seven normal @entity1 (NW; BMI 20.3 +/- 1.7 kg/m(2)). Basal ghrelin levels in NW were higher than in OB (P < 0.05). In NW, ghrelin increased (P < 0.05) GH, prolactin (PRL), ACTH, @entity701 , and @entity413 levels but did not modify insulin. In OB, ghrelin increased (P < 0.01) GH, PRL, ACTH, and @entity701 levels. The GH response to ghrelin in OB was 55% lower (P < 0.02) than in NW, whereas the PRL, ACTH, and @entity701 responses were similar. In OB, ghrelin increased @entity413 and reduced insulin (P < 0.05). Thus, @entity28 shows remarkable reduction of the somatotroph responsiveness to ghrelin, suggesting that ghrelin hyposecretion unlikely explains the @entity73 function in @entity28 . On the other hand, in @entity28 ghrelin shows preserved influence on PRL, ACTH, and insulin secretion as well as in @entity413 levels.
