microRNA and Bone XXXX .

@entity2828 @entity511 @entity3478 @entity5 @entity7762 @entity2967 @entity45620 @entity421 @entity3 @entity105 @entity5607
UNASSIGNED: MicroRNA molecules have a variety of roles in cellular development and proliferation processes, including normal osteogenesis. These effects are exerted through post-translational inhibition of target genes. Altered miRNA expression has been demonstrated in several @entity5 , both in the @entity5 tissue and in the peripheral circulation. This may influence @entity105 if the specific miRNA targets are encoded by @entity5 suppressor genes or oncogenes. To date, most research investigating the role of microRNAs and primary @entity3478 has focused on @entity421 and @entity2828 . Several microRNAs including the @entity7762 family have been implicated in @entity105 via effects on the Notch signaling pathway. Progression, invasion, and @entity3 of @entity421 cells is also influenced by microRNA expression. In addition, microRNA expression may affect the response to chemotherapy in @entity421 and thus hold potential for future use as either a prognostic indicator or a therapeutic target. The @entity45620 fusion protein produced in @entity2828 has been shown to induce changes in miRNA expression. MicroRNA expression profiling may have some potential for prediction of disease progression and survival in @entity2828 . There is limited evidence to support a role for microRNAs in other primary @entity3478 , either malignant or benign; however, early work is suggestive of involvement in @entity511 , @entity5607 , and @entity2967 of bone.
