Preoperative neutrophil-lymphocyte ratio predicts XXXX among @entity1 with localized clear cell renal carcinoma undergoing nephrectomy.

@entity1 @entity39 @entity5 @entity1358 @entity3 @entity204
OBJECTIVES: The neutrophil-lymphocyte ratio (NLR) is an indicator of the systemic inflammatory response. An increased pretreatment NLR has been associated with adverse outcomes in other @entity5 , but its role in localized (M0) @entity1358 ( @entity1358 ) remains unclear. As such, we evaluated the ability of preoperative NLR to predict oncologic outcomes in @entity1 with M0 @entity1358 undergoing radical nephrectomy (RN). METHODS AND MATERIALS: From 1995 to 2008, 952 @entity1 underwent RN for M0 @entity1358 . Of these, 827 (87%) had pretreatment NLR collected within 90 days before RN. @entity3 -free, @entity5 -specific, and overall survival was estimated using the Kaplan-Meier method and compared using the log-rank test. Multivariate models were used to analyze the association of NLR with clinicopathologic outcomes. RESULTS: At a median follow-up of 9.3 years, 302, 233, and 436 @entity1 had distant @entity3 , @entity204 from @entity1358 , and all-cause mortality, respectively. Higher NLR was associated with larger @entity5 size, higher nuclear grade, @entity39 , and sarcomatoid differentiation (all, P<0.001). A NLR>= 4.0 was significantly associated with worse 5-year @entity5 -specific (66% vs. 85%) and overall survival (66% vs. 85%). Finally, after controlling for clinicopathologic features, NLR remained independently associated with risks of @entity204 from @entity1358 and all-cause mortality (hazard ratio for 1-unit increase: 1.02, P< 0.01). CONCLUSIONS: Our results suggest that NLR is independently associated with increased risks of @entity5 -specific and all-cause mortality among @entity1 with M0 @entity1358 undergoing RN. Accordingly, NLR, an easily obtained marker of biologically aggressive @entity1358 , may be useful in preoperative @entity1 risk stratification.
