Low-density lipoprotein receptor-related protein is decreased in XXXX of @entity195 .

@entity1 @entity4215 @entity8993 @entity1781 @entity195 @entity528
BACKGROUND: @entity195 ( @entity195 ) is associated with @entity528 , yet the underlying pathophysiology of this disease and the @entity1781 remain poorly understood. Low-density lipoprotein receptor-related protein ( @entity8993 ) is implicated in the pathogenesis of @entity195 by mediating the transport of amyloid-b (Ab) out of the brain into the systemic circulation. As a key player in the reaction to central @entity4215 , astrocytes associate with @entity8993 in @entity195 . This study investigates the role of @entity8993 and astrocytes in the pathogenesis of @entity1781 . METHODS: To investigate the role of @entity8993 and astrocytes in the pathogenesis of @entity1781 , we conducted immunohistochemical studies on postmortem optic nerves in @entity195 @entity1 (n = 11) and age-matched controls (n = 10) to examine the presence of @entity8993 . Quantitative analyses using imaging software were used to document the extent of @entity8993 in neural tissues. Axonal integrity was assessed by performing immunohistochemistry on the subjects' optic nerves with an antibody to neurofilament (NF) protein. Double-immunofluorescence labeling was performed to investigate whether @entity8993 colocalized with astrocytes, expressing glial fibrillary acidic protein. RESULTS: @entity8993 expression was decreased in @entity195 optic nerves compared to that in controls (P < 0.001). @entity8993 immunoreactivity was observed in the microvasculature and perivascularly in close proximity to the astrocytic processes. Colocalization of @entity8993 in the astrocytes of optic nerves was also demonstrated. The presence of @entity1781 was confirmed in the @entity195 optic nerves by demonstrating greatly reduced immunostaining for NF protein as compared to controls. CONCLUSIONS: The reduction of @entity8993 in the @entity1781 supports the hypothesis that @entity8993 may play a role in the pathophysiology of @entity1781 .
