XXXX and mortality in the Golestan Cohort Study: A prospective study of 50   000 adults in Iran.

@entity1 @entity64 @entity101 @entity741 @entity204 @entity65
UNASSIGNED: @entity101 has been the second most important determinant of disease burden in Iran since the 1990s. Despite well-recognized evidence on the association of high blood pressure and mortality in other countries, this relationship has not been fully investigated in the demographic setting of Iran. The current study is the first large-scale longitudinal study of this association in Iran. Briefly, 50   045 subjects between 40 and 75 years of age have been recruited and followed. Blood pressure measurements were carried out at baseline. Causes of @entity204 were reported and verified by verbal autopsy throughout the follow-up period. The outcomes of interest were all-cause @entity204 and @entity204 due to @entity741 ( @entity741 ) or @entity64 . Cox proportional hazards regression models were used to estimate hazard ratios (HRs). A total of 46 674 subjects free from @entity65 at baseline were analyzed. Absolute mortality rates increased along with increasing systolic or diastolic blood pressure above 120 and 80   mm   Hg, respectively. Adjusted HRs (95% confidence intervals) for each 20   mm   Hg increase in systolic blood pressure in all age groups were 1.18 (1.13-1.23) for all-cause mortality, 1.21 (1.13-1.31) for @entity204 due to @entity741 and 1.50 (1.39-1.63) for @entity204 due to @entity64 . Unadjusted and adjusted HRs were higher in younger subjects and decreased with increasing age of the @entity1 . @entity101 is a serious threat to the health of Iranians. The entire health-care system of Iran should be involved in a comprehensive action plan for controlling blood pressure.Journal of @entity1 @entity101 advance online publication, 11 June 2015; doi:10.1038/jhh.2015.57.
