Factors affecting radiographic progression of XXXX .

@entity1 @entity1143 @entity626 @entity32 @entity571 @entity24178 @entity6661 @entity1463
OBJECTIVES: To evaluate the prognostic significance of @entity1 characteristics and radiographic features at the knee for outcome of @entity626 . METHODS: This was a prospective observational study of 350 osteoarthritic knees. Clinical and radiographic data were obtained on 188 hospital referred @entity1 (mean age 70, range 34-91 years). RESULTS: Median duration of follow up was two years (range 1-5 years). The majority of @entity1 (48%) reported deterioration, but 23% experienced improvement in symptoms during the study period. Reported exercise tolerance remained unchanged in the majority (62%) and deteriorated in 35%. Change in at least one individual radiographic feature of @entity571 was seen in 252 (72%) knees: increase in joint space narrowing occurred in 52%, osteophyte in 32%, cysts in 19%, @entity1463 in 14%, and @entity6661 in 30%. Increase in Kellgren grade occurred in 137 (39%) knees. @entity1143 , @entity571 at multiple joint sites, and nodal change associated with change in Kellgren grade (odds ratios 1.03, 2.39, and 1.80; 95% confidence intervals (CI) 1.01 to 1.05, 1.16 to 4.93, and 1.02 to 3.17, respectively); warmth at the knee associated with change in any radiographic feature (odds ratio 2.22; 95% CI 1.19 to 4.14). Development of, or increase in, @entity6661 and joint space narrowing associated with worsening symptoms and function and occurred with increased frequency in knees with effusions, clinical warmth and @entity24178 crystals in synovial fluid (p < 0.05). CONCLUSIONS: A high rate of change, radiographic more than clinical, was seen in osteoarthritic knees during this study. Poor clinical and radiographic outcome associated with @entity24178 crystal deposition and clinical @entity32 as reflected by knee effusion and warmth.
