Quantitative evaluation of ischemic XXXX by unenhanced T1 mapping using 3.0 Tesla MR scanner.

@entity1 @entity296 @entity3145 @entity453 @entity583
PURPOSE: We aimed to use a noninvasive method for quantifying T1 values of chronic @entity583 scar by cardiac magnetic resonance imaging (MRI), and determine its diagnostic performance. MATERIALS AND METHODS: We performed cardiac MRI on 29 consecutive @entity1 with known @entity453 ( @entity453 ) on 3.0 Tesla MRI scanner. An unenhanced T1 mapping technique was used to calculate T1 relaxation time of @entity296 , and its diagnostic performance was evaluated. @entity3145 was identified by delayed contrast-enhancement (DE) MRI and T2-weighted images. Sensitivity, specificity, and accuracy values were calculated for T1 mapping using DE images as the gold standard. RESULTS: Four hundred and forty-two segments were analyzed in 26 @entity1 . While myocardial chronic scar was demonstrated in 45 segments on DE images, T1 mapping MRI showed a chronic scar area in 54 segments. T1 relaxation time was higher in chronic scar tissue, compared with remote areas (1314  98 ms vs. 1099  90 ms, P < 0.001). Therefore, increased T1 values were shown in areas of myocardium colocalized with areas of DE and normal signal on T2-weighted images. There was a significant correlation between T1 mapping and DE images in evaluation of myocardial wall injury extent (P < 0.05). We calculated sensitivity, specificity, and accuracy as 95.5%, 97%, and 96%, respectively. CONCLUSION: The results of the present study reveal that T1 mapping MRI combined with T2-weighted images might be a feasible imaging modality for detecting chronic @entity583 scar tissue.
