Surveillance of the antibiotic susceptibility of non-penicillinase producing XXXX in The Netherlands from 1983 to 1986.

@entity2261 @entity6368 @entity2953 @entity114 @entity2177 @entity3524 @entity1521 @entity10083 @entity803 @entity6760
From 1983 to 1986 more than 2000 non-penicillinase producing @entity6368 from Amsterdam, The Hague and Rotterdam were auxotyped and screened for susceptibility to 10 antibiotics by MIC determination. By far the commonest auxotypes were N.R. (non-requiring; 40%) and Pro- ( @entity1521 requiring; 30%). During that period there was a substantial shift in the ratio of both auxotypes-roughly from 1:2 to 2:1-in The Hague. Pro- isolates were generally less susceptible than N.R. isolates, and there was a strong positive correlation between the MICs of the different drugs. The prevalence of isolates with a @entity114 MIC equal to or above 0.5 IU/ml amounted to 14%, while in only 1% was the MIC above 1 IU/ml. Comparing our results with an earlier study by Stolz, Zwarte _ Michel (1975, British Journal of @entity2953 51, 257-64), the level of resistance to @entity114 among non-PPNG has not significantly increased in The Netherlands since 1972. The prevalence of isolates showing relative resistance towards @entity803 and @entity10083 (MIC 2-4 mg/l) decreased from approximately 20% in 1983/84 to approximately 10% in 1985/86, coinciding with a drop in the prevalence of Pro- isolates. All strains were susceptible to @entity2261 and @entity6760 and highly susceptible to @entity3524 and @entity2177 .
