Experimental XXXX media with effusion induced by leukotriene D4.

@entity1 @entity1356 @entity4443 @entity310 @entity2918 @entity35 @entity2171 @entity1440 @entity2346
OBJECTIVE: inflammatory mediators such as @entity2918 (PGs), @entity4443 (LTs), and platelet-activating factor (PAF) have been identified in @entity1 @entity2171 ( @entity2171 ), as well as in the experimentally induced @entity2171 of animals. However, the exact function of LTs in the middle ear cavity is still unknown. In this study, the role of LTs was investigated using an experimental model in which OME was induced by LTD4. METHODS: to examine whether leukotrienes (LTs) induce @entity2346 media with effusion (OME), 2x10(-6), 2x10(-5), 1x10(-4) and 2x10(-4) M of LTD4 was injected into the @entity35 ear. The severity of OME was assessed based on the histological findings. The concentrations of @entity1356 , @entity310 , and GRO/CINC-1 in @entity2171 were also measured. Additionally the therapeutic efficacy of a specific LTs antagonist, @entity1440 on experimental OME was investigated. RESULTS: all ears developed @entity2171 ( @entity2171 ) within 24 h and about 50% of the animals continued to demonstrate @entity2171 for 14 days in the 1x10(-4) and 2x10(-4) M groups. The cytokine levels seemed to correspond well with the persistence of OME. The oral administration of a specific LTs antagonist, @entity1440 , was found to alleviate the experimental OME. CONCLUSION: these findings suggest that LTs appear to plays an important role in the pathogenesis of OME.
