Long-term efficacy, curative potential, and prognostic factors of radiotherapy in primary XXXX .

@entity1 @entity706 @entity55 @entity1892 @entity272
PURPOSE: Primary @entity1892 (PCBCL) are rare and constitute approximately 5-10% of all @entity706 . In the literature, conflicting data exist on the optimal treatment modality regarding the efficacy and the relapse rate after radiotherapy (RT) or polychemotherapy. To evaluate the efficacy of RT, @entity1 data from two centers were analyzed and compared with recent reports in the literature. MATERIALS AND METHODS: Between April 1984 and June 2001, 35 @entity1 with PCBCL, 17 @entity1 and 18 @entity1 ages 27-86 years, were treated with RT alone (29/35 @entity1 ) or postoperative RT (6/35 @entity1 ). According to the European Organization for Research and Treatment of Cancer classification for PCBCL, this study group included 21 @entity1 (60%) with primary cutaneous follicle center-cell lymphoma, 7 (20%) with primary cutaneous immunocytoma, 4 (11%) with primary cutaneous large @entity1892 (PCLBCL) of the leg, and 3 (9%) provisional types. RESULTS: A total of 34/35 @entity1 achieved an initial complete response after RT. In one additional @entity1 , RT was interrupted after 16 Gy because of fulminant @entity55 . A total of 11/35 (31%) @entity1 developed cutaneous relapse after a median of 11 months. Three @entity1 developed an in-field response and 8 @entity1 an out-field relapse. After a median follow-up of 52 months, 27/35 @entity1 are alive, whereas 8/35 @entity1 died (three deaths resulting from PCBCL and five unrelated to PCBCL). The 5-year overall survival rate was 75% (95% CI: 55-95%). The 5-year relapse-free survival was 50% (95% CI: 32-68%). Univariate and multivariate analysis revealed disseminated primary lesions in at least two noncontiguous anatomic sites and the histologic subtype PCLBCL as unfavorable prognostic factors. CONCLUSIONS: RT of all visible @entity272 is an effective treatment for localized PCBCL. In @entity1 with cutaneous relapses, RT is an effective treatment option as well.
