[Use of PGE1 in severe XXXX of the lower extremities. Clinical study].

@entity1 @entity63 @entity26 @entity158 @entity432 @entity10
Lower limb critical @entity63 is a clinical condition typical of @entity1 with severe @entity432 (Fontaine's IIIb and IV degree). This condition often leads to amputation of the limb involved. The authors present to the use PGE1 in 50 @entity1 with Fontaine's IIIb-IV degree @entity432 of lower limbs in which the indication of amputation was done. All the @entity1 , admitted to the emergency ward, complain of @entity158 and distal ulcers. The administration of PG5(1) was given as follows: 40 mg/bid/e.v./20 days. A 6 months long follow-up was installed with the instrumental evaluation of: Transcutaneous @entity26 pressure; Distal blood perfusion with Doppler; cardiac pulse; blood pressure. Eighteen @entity1 became to a Fontaine's II degree during the next 2 months after therapy, 25 @entity1 came back to a severe claudicatio: of them 18 underwent successfully vascular surgery, 7 underwent amputation of the lower limb. In 7 @entity1 the PGE1 did not influence the natural progression of the disease. Among the side-effects of therapy we can mention: @entity10 (4%), erythema and @entity158 of injected vein (8%), sick (4%). All the side effects were transient and never led to interruption of therapy.
