@entity1529 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with @entity2812 -induced XXXX in Mexican Mestizo @entity1 .

@entity1 @entity2812 @entity6715 @entity29597 @entity2050 @entity1910 @entity1529 @entity10535 @entity2049 @entity3174 @entity18698 @entity734
AIM: Several HLA alleles have been associated with @entity734 ( @entity734 )-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in @entity10535 ( @entity10535 ). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in @entity10535 @entity1 . MATERIALS _ METHODS: This case-control association study included 21 @entity10535 @entity1 with @entity3174 ( @entity29597 )-, @entity2049 ( @entity2050 )-, or @entity2812 (LTG)-induced @entity1910 ( @entity1910 ) or @entity6715 ( @entity6715 ); 31 @entity10535 @entity1 tolerant to the same @entity734 ; and 225 unrelated, healthy @entity10535 volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR @entity1 and AED-tolerant @entity1 were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in @entity10535 @entity1 were compared with those in @entity10535 population. RESULTS: The frequency of @entity18698 *08:01 allele in @entity29597 -induced @entity1910 was higher than that in the @entity29597 -tolerant group (pc = 0.0179) or in the @entity10535 population (pc < 0.0001). For the first time, @entity1529 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced @entity1910 (pc = 0.0048 for LTG-tolerant groups and pc < 0.0001 for @entity10535 population). CONCLUSION: Our data suggest the @entity1529 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced @entity1910 and the @entity18698 *08:01 allele for @entity29597 -induced @entity1910 . We also identified @entity1529 *01:01:01 and -A*31:01:02 as candidates alleles associated with @entity2050 -induced @entity1910 in @entity10535 @entity1 . However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014.
