@entity4 and loss of photoreceptors in chronic XXXX and experimental @entity726 .

@entity1 @entity725 @entity4 @entity726 @entity2788 @entity2608 @entity3641
OBJECTIVE: To determine whether outer retinal changes occur in chronic, presumed @entity725 ( @entity725 ). METHODS: The outer retinas from 128 @entity1 eyes with a diagnosis of chronic @entity726 (presumably @entity725 in most cases) and 90 control eyes were examined histologically by 3 masked observers for photoreceptor swelling and loss. Retinas from 9 @entity2608 with @entity726 induced experimentally by laser trabecular destruction were compared with 7 fellow (control) eyes. The mean pressure elevations in the eyes with laser trabecular destruction ranged from 26.6 to 53.6 mm Hg with durations varying from 7 to 33 weeks. RESULTS: @entity4 of the red- and green-sensitive cones was observed in a statistically significantly greater proportion of @entity1 eyes with presumed @entity725 compared with the control eyes. Patchy loss of red/green cones and rods was also found in some of the @entity2788 . In a subset of the @entity1 eyes with end-stage disease, cone swelling was a variable finding. Although no photoreceptor loss was found in the 9 monkey eyes with experimental @entity726 , 8 had swelling of their red/green cones that was remarkably similar to that seen in the @entity1 eyes. @entity4 was not present in any of the control monkey eyes. CONCLUSIONS: The photoreceptors are affected by chronically elevated intraocular pressure. CLINICAL RELEVANCE: These findings may explain some of the @entity3641 and the electrophysiological effects that have been observed in @entity1 with @entity725 .
