Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left XXXX .

@entity1 @entity1472 @entity712 @entity3876 @entity299 @entity67 @entity1002
OBJECTIVES: The purpose of this study was to investigate circulating pro-B-type natriuretic peptide (proBNP(1-108)) in the general community and evaluate its ability to detect left @entity67 . BACKGROUND: The current concept for cardiac endocrine function is that, in response to cardiac stress, the heart secretes B-type natriuretic peptide ( @entity3876 (1-32)) and @entity1472 -terminal pro-B-type natriuretic peptide (NT-proBNP(1-76)) after intracardiac cleavage of their molecular precursor, proBNP(1-108). We hypothesized that proBNP(1-108) circulates in normal @entity1 subjects and that it is a useful biomarker for @entity1002 . METHODS: Our population-based study included a cohort of 1,939 adults (age >= 45 years) from Olmsted County, Minnesota, with 672 @entity1 defined as healthy. Subjects underwent in-depth clinical characterization, detailed echocardiography, and measurement of proBNP(1-108). Independent factors associated with proBNP(1-108) and test characteristics for the detection of @entity1002 were determined. RESULTS: ProBNP(1-108) in normal @entity1 was strongly influenced by sex, age, heart rate, and body mass index. The median concentration was 20 ng/l with a mean proBNP(1-108) to NT-proBNP(1-76) ratio of 0.366, which decreased with @entity712 stage. ProBNP(1-108) was a sensitive (78.8%) and specific (86.1%) biomarker for detecting LV @entity299 , which was comparable to @entity3876 (1-32), but less than NT-proBNP(1-76), in several subsets of the population. CONCLUSIONS: ProBNP(1-108) circulates in the majority of healthy @entity1 in the general population and is a sensitive and specific biomarker for the detection of @entity299 . The proBNP(1-108) to NT-proBNP(1-76) ratio may provide insights into altered proBNP(1-108) processing during @entity712 progression. Thus, this highly specific assay for proBNP(1-108) provides important new insights into the biology of the @entity3876 system.
