A randomized trial of classical and medium-chain @entity412 ketogenic diets in the treatment of childhood XXXX .

@entity1 @entity4323 @entity410 @entity391 @entity4322 @entity412 @entity302 @entity6178
PURPOSE: To conduct the first randomized trial on classical and medium-chain @entity412 (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS: One hundred forty-five @entity1 with intractable @entity302 were randomized to receive a classical or an MCT diet. @entity410 frequency was assessed after 3, 6, and 12 months. Treatment withdrawals were documented. Tolerability was assessed by questionnaire, and blood @entity6178 levels were measured. RESULTS: Of the 61 @entity1 who started a classical diet and the 64 who started an MCT diet, data from 94 were available for analysis: 45 classical and 49 MCT. After 3, 6, and 12 months there were no statistically significant differences in mean percentage of baseline @entity410 between the two groups (3 months: classical 66.5%, MCT 68.9%; 6 months: classical 48.5%, MCT 67.6%; 12 months: classical 40.8%, MCT 53.2%; all p > 0.05). There were no significant differences between groups in numbers achieving greater than 50% or 90% @entity410 reduction. Serum @entity4323 and @entity4322 levels at 3 and 6 months were significantly higher in @entity1 on the classical diet (p < 0.01); this was the case at 12 months for @entity4323 . There were no significant differences in tolerability except increased reports in the classical group of lack of energy after 3 months and @entity391 after 12 months. DISCUSSION: This study has shown classical and MCT ketogenic diet protocols to be comparable in efficacy and tolerability; both ways of implementing the diet have their place in the treatment of childhood @entity302 .
