Phthisis bulbi--an intraocular XXXX proliferative reaction.

@entity1 @entity548 @entity3145 @entity1388 @entity1347 @entity5995 @entity551
This study reports the findings in 74 mainly posttraumatic phthisical @entity1 eyes enucleated after varying time intervals. It was usually a result of severe @entity1347 with marked @entity548 and @entity3145 . In summary, the tissue reactions in these eyes are those known from wound healing elsewhere in the body with additional traction changes and @entity551 . In phthisis bulbi the complex reactions associated with inflammatory, healing, and scarring processes reach a maximum within the first 3 months, but can go on for years. Cell proliferation and transformation are early and important features of this process which lead to @entity5995 and ciliochoroidal detachment, @entity551 and marked shrinkage of the globe. The results also indicate that reactions initiated by intraocular @entity548 have an important part in the development of phthisis bulbi. The process of phthisis bulbi is a process of wound healing in the sense of an intraocular @entity1388 proliferative reaction. Main areas of proliferation are the pars plana of the ciliary body, the optic disc and the base of the iris. Finally degenerative changes will develop additionally. It appears that repair of the injured tissues with early primary (within 6 h) and secondary (within the first 2 weeks) intraocular surgery and other preventive surgical measures should be performed by an experienced surgeon. Further work on postoperative medical treatment to control the secondary reactions is needed. To compare the therapeutic efforts a 5-stage classification is proposed.
