Age-related expression of @entity876 , @entity7465 , XXXX and @entity4311 in @entity463 multiforme.

@entity1 @entity7465 @entity470 @entity4311 @entity32934 @entity876 @entity1758 @entity463
OBJECTIVE: @entity463 ( @entity463 ) is a major cause of morbidity and mortality in neurosurgical @entity1 . Despite the overall poor prognosis a range in survival times exists. Many approaches have been undertaken to define @entity1 subgroups based on molecular changes. The aim of this study was to assess a possible correlation between the immunohistochemical @entity876 , @entity7465 , @entity470 and @entity4311 expression and age. METHOD: 143 @entity1 (77 male, 66 female) were included in this retrospective study who underwent craniotomy for newly-diagnosed @entity463 between May 1994 and February 2000. For statistical analysis, @entity1 were separated into three age groups: 1. < 40 years, 2. 40-60 years, 3. > 60 years. Immunohistochemical staining (IHC) was performed using anti- @entity876 (clone DO-1), anti- @entity7465 (clone @entity32934 ), anti- @entity470 (clone H11) and anti- @entity4311 antibodies (clone AB-1). The results were compared with the Ki67/ @entity1758 proliferation index (Ki67 PI) and @entity1 survival. FINDINGS: @entity876 protein expression was significantly decreasing with advanced age (p < 0.05) whereas @entity470 and @entity7465 expression was increasing (p < 0.05; p=0.01). @entity4311 expression was unrelated to age. Multivariate analysis revealed @entity4311 protein expression as a significant predictor of prolonged survival (p=0.004) whereas @entity876 , @entity7465 and @entity470 were not associated with @entity1 survival. @entity876 , @entity7465 , @entity470 and @entity4311 expression was not associated with the Ki67 PI. INTERPRETATION: Our results support the hypothesis that in @entity463 @entity1 a complex relationship exists between the @entity876 , @entity7465 and @entity470 expression and age. @entity4311 expression is not related to age. Notably, nuclear @entity4311 expression turned out to be an independent prognostic indicator.
