Kinetic study of platelets and XXXX in @entity26211 -infected monkeys and early pathologic events in Mopeia virus-infected monkeys.

@entity2002 @entity8 @entity26210 @entity26211 @entity5642 @entity2608 @entity922
The @entity2608 , an established model of @entity26210 , was used to study hematologic and hemostatic aspects of @entity26210 and whether Mopeia (also known as Mozambique) virus induces any cellular damage in this model. Six days after subcutaneous injection of 10(3.48) plaque forming units (PFU) of @entity26211 (Josiah strain) one group of monkeys received an intravenous injection of 111In-labeled allogeneic platelets and another group received 125I-labeled alogeneic @entity2002 . @entity26211 -infected monkeys developed a severe @entity922 and typical pathology. Lassa antigen was found in most tissues using a Lassa nucleocapsid-specific monoclonal antibody. Platelet counts remained within normal limits. Platelet and @entity2002 kinetics were similar in infected and control animals. Hematologic and hemostatic changes indicate that disseminated @entity5642 plays no role in this model of @entity26210 . Levels of plasma fibronectin were reduced in Lassa-infected monkeys. Mopeia virus-infected monkeys were normothemic, aviremic, and there was no detection of Mopeia antigen in any tissues using polyclonal or monoclonal antibodies. Mopeia virus was recovered from the spleen of one monkey. Mopeia virus was associated with hepatocellular and @entity8 .
