The development and inflammatory features of radiotherapy-induced @entity35160 in XXXX .

@entity3136 @entity39 @entity19 @entity1066 @entity5932 @entity8307 @entity35160 @entity35
OBJECTIVES: To improve the existing animal models ( @entity19 , @entity35 , and hamsters) for radiotherapy-induced @entity3136 (RTOM), thereby establishing a radiotherapy-induced @entity35160 (RTG) Sprague-Dawley (SD) @entity35 model. STUDY DESIGN: A lead device was designed to limit radiation exposure to a 1x1 cm2 area of a @entity35 's dorsal anterior tongue with a single 30 Gy of X-ray radiation. The general conditions of the irradiated @entity35 , such as body-weight and behavior, were observed. The @entity3136 index (OMI) of the RTG @entity35 were measured daily. Histological changes of the irradiated tongue tissues were assayed by H _E staining. RESULTS AND CONCLUSION: No significant changes were clinically observed 3 to 4 days after irradiation. At 5 to 6 day, punctuation and confluenced @entity5932 were observed. The small blood vessels became more extensive, engorged, thin vessel walls. More infiltrating cells were observable, @entity39 and exfoliation of the squamous cells appeared, and the formation of an @entity1066 could be observed. Seven to 15 days, the exfoliated epithelial layer was observed to have formed an @entity1066 , then aggravated @entity1066 consisting of @entity8307 exudates could be observed. The structure of the epithelium had become completely disintegrated, forming deep, microscopic @entity1066 . Twenty-one days, the periphery of the @entity1066 was observed to have begun to heal, and granulation tissue could be observed at the bottom of the @entity1066 . At 35 days after irradiation, the epithelial structure presented again, but the epithelium was very thin. An RTG animal model was successfully established in SD @entity35 , which provides a new research platform for the study of RTOM pathogenesis.
