Postchallenge plasma lipoprotein @entity4878 : chylomicron remnants in endogenous XXXX .

@entity1 @entity2298 @entity4878 @entity15994 @entity6308 @entity904 @entity4280 @entity5522 @entity412 @entity17326 @entity731 @entity165
This study was conducted to determine whether chylomicron remnants accumulate in the plasma of @entity1 with "endogenous" @entity2298 . @entity15994 were used as markers of chylomicrons and chylomicron remnants since they are carried mainly if not exclusively by lipoproteins of intestinal origin. Seventy-six fasting normotriglyceridemic and @entity6308 @entity1 were studied 12 to 15 hours after ingesting 25,000 IU of @entity904 . Plasma @entity904 and @entity15994 were measured by reversed-phase high-performance liquid chromatography. @entity17326 was assessed by flotation at unit gravity and by chylomicron flocculation in 3% @entity4280 . Plasma lipids, @entity4878 , lipoprotein @entity165 , and the electrophoretic mobility of very-low density lipoproteins were determined in a subset of 36 subjects. Progressively elevated plasma @entity15994 concentrations were observed among @entity1 with mild, moderate, and severe @entity2298 . All subjects with fasting @entity17326 had @entity15994 retention. The majority of subjects with mild or moderate @entity2298 (predominantly type IV @entity5522 ) also had elevated plasma concentrations of @entity15994 . Total plasma @entity15994 and plasma @entity412 concentrations correlated significantly (rs = 0.721, P less than 0.001) in nonchylomicronemic subjects. In addition, total plasma @entity904 concentrations were mildly elevated among @entity6308 subjects because @entity904 , as well as @entity15994 , is transported by @entity412 -rich lipoproteins. If lipoprotein remnants are atherogenic in @entity1 , then chylomicron remnant retention may accelerate @entity731 in @entity6308 individuals.
