The role of @entity1476 , @entity1495 , and @entity2843 in the pathogenesis of XXXX : Immunohistochemical assessment at eight different levels in the epithelial, subepithelial, and deep layers of the mucosa.

@entity1 @entity82 @entity1127 @entity1476 @entity4 @entity2843 @entity1495 @entity655 @entity1412 @entity480
We conducted a prospective study to investigate the role of @entity1476 ( @entity1476 ), @entity1495 ( @entity1495 ), and @entity2843 ( @entity2843 ) in the pathogenesis of @entity480 . Our study group consisted of 24 @entity1 -21 @entity1 and 3 @entity1 , aged 23 to 70 years (mean: 45.97    11.60)-with @entity1412 who underwent functional endoscopic sinus surgery. For comparison purposes, we assembled a control group of 11 @entity1 -6 @entity1 and 5 @entity1 , aged 18 to 56 years (mean: 29.90    14.22)-without @entity480 who underwent septoplasty and/or rhinoplasty. We analyzed 36 polyp specimens obtained from the study group (10 from the nasal cavity, 10 from the maxillary sinus, and 16 from the ethmoid sinus) and 11 tissue specimens from the control group (each control provided 1 specimen from the inferior turbinate). We then calculated the mean number of these cells in the epithelium, @entity655 , and the deep paraglandular layer of the mucosa. In general, we found that @entity1476 , @entity1495 , and @entity2843 values were higher in the nasal polyp group. These differences became less so as @entity1 ' ages and the duration of @entity1127 increased. We conclude that the most important role that @entity1476 plays in polyp growth may be in terms of perivascular localization and an increase in vascular permeability, which causes inflammatory cell migration and @entity4 in the extracellular matrix. An increase in @entity1476 in glandular tissue may lead to hydrolysis of tissue matrix components. The degraded extracellular matrix may result in @entity82 of the @entity1127 . An increase of @entity1495 in the apical part of the epithelium in the polypoid tissue of the nasal cavity, maxillary sinus, and ethmoid sinus may facilitate the epithelial and endothelial cell migration that is observed during polyp development and growth.
