Elevated numbers of tissue-factor exposing microparticles correlate with components of the @entity209 in XXXX .

@entity1 @entity32 @entity6 @entity4404 @entity5 @entity209 @entity731 @entity413 @entity165
BACKGROUND: Type 2 @entity6 is associated with accelerated @entity731 . Because cell-derived microparticles support coagulation and @entity32 , they may be involved in atherogenesis. We characterized circulating microparticles both in @entity1 with uncomplicated, well-regulated type 2 @entity6 and in healthy subjects, as well as their relationship with coagulation and metabolic control. METHODS AND RESULTS: Microparticles were isolated from plasma, stained with @entity4404 , cell-specific monoclonal antibodies (MoAbs) and a MoAb directed against tissue factor (TF), and analyzed by flow cytometry. Microparticle numbers and origin were comparable in the two groups, but the median number of TF-positive microparticles was twice as high in @entity1 than in controls (P=0.018). @entity1 had higher percentages of TF-positive microparticles from T-helper cells (P=0.045), granulocytes (P=0.004), and platelets (P=0.002). Subpopulations of TF-positive microparticles from platelets and T-helper cells exposed granulocytic markers. Correlations were found between the numbers of various TF-positive microparticle subpopulations and body mass index, fasting plasma @entity413 and insulin, or @entity5 necrosis factor-alpha and serum HDL @entity165 . Microparticles from @entity1 generated less thrombin in vitro (P=0.007). Microparticle numbers did not correlate with in vivo coagulation markers prothrombin fragment F(1+2) and thrombin-antithrombin complexes. CONCLUSIONS: TF, possibly of granulocytic origin, is exposed on microparticle subpopulations in asymptomatic @entity1 with well-regulated type 2 @entity6 . TF-positive microparticles are associated with components of the @entity209 but not with coagulation. Thus, TF on microparticles may be involved in processes other than coagulation, including transcellular signaling or angiogenesis.
