Early expression of XXXX following oral antigen administration is associated with peripheral tolerance induction.

@entity6306 @entity19 @entity60 @entity1618 @entity1959 @entity1960
Oral tolerance is the induction of immune @entity6306 to orally administered antigens. It was described in association with a decrease in @entity60 production by activated T cells. To determine the role of @entity60 and @entity1618 in immunemodulation via oral tolerization. @entity1960 was induced by intracolonic instillation of @entity1959 . Treated @entity19 received five oral doses of @entity1960 -extracted proteins (CEPs) every other day, starting immediately after @entity1960 induction. Control @entity19 received similar doses of bovine serum albumin. @entity1960 was assessed in both groups by standard clinical, micro- and macroscopic scores. @entity60 and @entity1618 expression in splenic lymphocytes from both groups was tested by RT-PCR immediately after oral feeding, 1, 4, 8, 12, and 24 h thereafter and then every 24 h for 2 weeks. Feeding of CEPs markedly ameliorated experimental @entity1960 . These @entity19 gained weight and showed markedly improved macro- and microscopic parameters of @entity1960 . Tolerized @entity19 exhibited @entity60 expression in splenic lymphocytes starting immediately following oral CEP immunization and up to 14 d thereafter. @entity1618 was expressed starting 1 h after CEP feeding and during the first 48 h thereafter. In contrast, non-tolerized control @entity19 manifested @entity60 expression starting on day 6 and had no @entity1618 expression. Early induction of @entity60 expression by oral antigen may be associated with systemic tolerance in the experimental @entity1960 setting. In contrast, late expression of @entity60 is associated with a pro-inflammatory response in non-tolerized controls.
