Optimal serum XXXX concentrations are associated with accelerated @entity604 in African ancestry @entity1 .

@entity1 @entity1674 @entity604 @entity79 @entity412 @entity165
UNASSIGNED: We tested if serum lipid and lipoprotein @entity165 levels are associated with longitudinal measures of @entity79 ( @entity79 ) in 1289 African ancestry @entity1 . After 6  years of mean follow-up, @entity1 with clinically optimal levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), or @entity1674 at baseline experienced the greatest @entity79 loss, independent of potential confounding factors (all p   <   0.05). INTRODUCTION: Studies of lipid and lipoprotein @entity165 associations with @entity79 ( @entity79 ) and @entity604 have been inconclusive, and longitudinal data are sparse. Therefore, the aim of this study was to test if fasting serum lipid and lipoprotein @entity165 levels are associated with areal and volumetric @entity79 and @entity79 change. METHODS: We determined the association of serum @entity1674 , high-density lipoprotein (HDL), and low-density lipoprotein (LDL) @entity165 concentrations with cross-sectional and longitudinal (mean follow-up, 6.1  years) measures of @entity79 in a cohort of 1289 in African ancestry @entity1 (mean age, 56.4  years). Fasting serum @entity1674 , HDL, and LDL were measured at baseline concurrent with @entity79 assessments. Dual-energy X-ray absorptiometry was used to quantify integral hip @entity79 , and peripheral quantitative computed tomography at the radius and tibia was used to quantify volumetric @entity79 . @entity1 were categorized as optimal, borderline, or high risk for @entity412 , HDL, and LDL concentrations based on Adult Treatment Panel III guidelines. RESULTS: Lower serum @entity412 or LDL and higher HDL concentrations were associated with lower trabecular @entity79 at baseline (all p   <   0.05). Similarly, @entity1 classified as having optimal levels of LDL, HDL, or @entity1674 at baseline experienced the greatest integral @entity79 loss at the hip and trabecular @entity79 loss at the tibia (all p   <   0.05), independent of potential confounding factors. CONCLUSIONS: We found that clinically optimal serum lipid and lipoprotein @entity165 concentrations were associated with accelerated @entity604 among Afro-Caribbean @entity1 . Further studies are needed to better understand the mechanisms involved and potential clinical significance of these findings.
