Potentiated hormonal responses in a model of XXXX .

@entity548 @entity235 @entity1425 @entity701 @entity1122 @entity1063 @entity130 @entity774
Although @entity130 often involves repeated insults, few studies have examined the endocrine response to @entity130 . In earlier work, we described potentiated responses of circulating adrenocorticotropin (ACTH) and adrenal secretion of @entity701 , @entity1425 , and @entity1063 to the second of two small @entity548 separated by 24 hr. To investigate the response of other hormones to repeated @entity548 and to examine possible hormonal interactions in a shorter, more clinically relevant time frame, we placed chronic @entity774 in eight splenectomized, trained @entity235 . Each animal was bled 10% of measured blood volume with reinfusion of shed blood at 30 min. The @entity548 was repeated 5 hr later. Initial @entity548 led to a small but significant increase in adrenal @entity701 secretion and circulating ACTH, vasopressin (AVP), angiotensin II (AII), and plasma @entity1122 activity (PRA). Although a 5-hr time interval between stimuli is commonly thought to lead to @entity701 feedback, the circulating ACTH and adrenal @entity701 secretory responses to the second @entity548 were exaggerated in comparison to their initial responses. Similarly, the AVP response to the second @entity548 was also increased. In contrast, the responses of PRA and AII to the second @entity548 were not greater than their responses to the initial @entity548 . No differences in measured blood volume before each @entity548 or in the heart rate and arterial pressure responses to @entity548 were observed that could explain the potentiated hormonal responses. Thus, potentiated responses of @entity701 , ACTH, and AVP, but not of PRA and AII, were observed in a model of @entity130 that emphasizes @entity130 in a clinically relevant time frame.(ABSTRACT TRUNCATED AT 250 WORDS)
