Role of Reactive XXXX Species and Advanced Glycation End Products in the Malfunctioning of Dental Implants.

@entity1 @entity7278 @entity26 @entity737 @entity177
OBJECTIVE: In the last decade, dental implants have emerged as a crucial modality and serve as an individual form of therapy for dental failure. However, disparities in host responses have led to @entity737 . The pathological mechanisms driving @entity737 remain largely unknown. In this study, we evaluated the role of oxidative stress and advanced glycation end products (AGE) in the progression of @entity737 and @entity177 , compared with @entity7278 . SUBJECTS AND METHODS: Three @entity1 groups ( @entity737 , @entity7278 and control), each with 10 subjects (7M/3F) and average age ranging from 40-60 years were selected for analysis. Salivary oxidative stress and tissue AGE levels were analysed by probing for reactive @entity26 species (ROS) and Maillard reaction-related fluorescence, respectively. RESULTS: We observed significant increase (> 2-fold) in oxidative stress and AGE levels in @entity1 with @entity737 and @entity7278 compared to controls, with @entity7278 having the highest levels. In addition, we observed a strong positive correlation (r = 0.94) between oxidative stress and AGE levels in the @entity1 . CONCLUSION: We propose that increased AGE levels and oxidative stress, although not the only pathway, are significant mediators in the pathogenesis of @entity737 . Altering them may potentially be used in combination with other modalities to manage @entity737 .
