Linezolid Bladder Irrigation as Adjunctive Treatment for a @entity2176 -Resistant XXXX Catheter-Associated Urinary Tract Infection: A Case Report.

@entity1 @entity2176 @entity6375 @entity810 @entity1696 @entity5136 @entity293
OBJECTIVE: To describe the first reported successful use of adjunctive linezolid bladder irrigation. CASE SUMMARY: An 89-year-old @entity1 with 10% TBSA burns developed @entity810 . She acquired a @entity293 caused by @entity2176 -resistant @entity6375 (VREfm). Based on clinical status, a linezolid bladder irrigation was initiated in addition to high-dose intravenous linezolid and demonstrated microbiological cure with 7 days of treatment. DISCUSSION: Linezolid is primarily hepatically cleared and has no labeled indication for @entity293 . @entity1696 adds an additional complication of potentially reduced urinary drug concentrations. Bladder irrigation offers the benefit of achieving high local drug concentrations, but there are no data regarding such a route for linezolid. This case report is the first demonstrating the use, stability, safety, and efficacy of @entity5136 as a continuous bladder irrigation. CONCLUSIONS: Linezolid use as a bladder irrigation may be a feasible route of administration in anuric, critically ill @entity1 with VREfm and few antimicrobial options. Further studies are warranted.
