Isolated systolic XXXX : how common? How risky?

@entity1 @entity64 @entity101 @entity13519 @entity453 @entity731 @entity13520
The following summary of the physiologic and epidemiologic evidence may help the clinician in making decisions when caring for @entity1 with ISH: ISH is predominantly found in older age groups, being present in 1% to 4% of the population under age 40, 10% to 15% between ages 60 and 70, and 25% to 30% over age 70. ISH is more prevalent in @entity1 than in @entity1 . The development of ISH in the aged is associated with a decrease in arterial compliance. The relationship whereby ISH is both a cause and a result of @entity731 vessels needs further delineation. Neurohumoral factors also have a part in determining arterial compliance. An elevated @entity13519 is an important contributor to the risk of developing @entity453 , and in @entity1 over 45 years old it is a more powerful predictor of coronary events than @entity13520 . @entity13519 is a better discriminator of risk for @entity64 at all ages than @entity13520 is. The relative risk in @entity1 with ISH for the development of @entity453 and @entity64 is two to five times that of normotensive @entity1 , but is no worse than the risk for these events among treated @entity101 . Although the relative risk of ISH is not strikingly large, the high prevalence of ISH among aged individuals, the increasing size of the population over 65 years old, and the high incidence rate of cardiovascular events in the aged give ISH a sizable attributable risk in the population (13 to 28 deaths per 1,000 individuals). It remains to be shown that lowering @entity13519 in ISH removes the risk of ISH. Studies are needed that monitor the costs and adverse effects of therapy as well as the possible benefits when a condition such as ISH is most commonly seen in the aged.
