[Results of long-term leukocyte interferon (alpha IFN) therapy using an individually determined dose schedule in recurrent XXXX ].

@entity1 @entity1185 @entity16850 @entity1129
Out of 24 @entity1 with @entity16850 6 (5 female, 1 male) suffered from repeated relapses and underwent long-term treatment with alpha-IFN-therapy. Age at onset of the disease: 1 5/12-16 2/12 years. Duration of illness: 1-7 years, with several relapses were treated surgically and with laser-coagulation. Three out of 6 @entity1 had a tracheal cannula and were cauterized by podophylline at 2-4 week intervals. IFN was given in dosages of 5-20 X 10(4) U/kg 2 or 3 times a week. IFN-dosage for each @entity1 was determined using the induction kinetics of (2'-5')-oligo(A)synthetase ( @entity1129 ) in the mononuclear cells of the circulating blood of @entity1 with @entity16850 . A continuous effect could be achieved by the dose of IFN determined in the described way always before @entity1129 activity decreased to its initial level. All 6 @entity1 responded favorably to the alpha-IFN-therapy. Two @entity1 treated only with IFN showed remission without relapses. In 2 cases IFN was successfully used to prevent relapses after surgical treatment and laser-coagulation. In 2 @entity1 with @entity1185 extending into the main bronchi the disease could only be brought to a standstill, i.e. it was not necessary to remove the @entity1185 . Two out of 3 @entity1 with @entity16850 could be decannulated. Long-term therapy following the above described principles is efficient and without significant side-effects. Three @entity1 are in treatment for more than 3 10/12 years.
