Effects of direct intravitreal XXXX injections on the development of lid-suture induced @entity1714 in @entity95 .

@entity1949 @entity2516 @entity935 @entity95 @entity3826 @entity735 @entity2955 @entity1714
BACKGROUND: @entity935 (DA) storage and release are reduced in @entity1714 ( @entity1714 ) in a wide range of species, from chicks to primates. @entity1714 can be prevented by treatment with DA agonists such as @entity3826 , and paradoxically by the @entity935 neurotoxin @entity2955 . In this study, we increased the DA levels by direct intravitreal DA injections to learn if @entity1714 can be suppressed in a @entity95 model. METHODS: Seven-day-old @entity95 were deprived of pattern vision by the suturing the right eyelids after natural eye opening. In the first group ( @entity1949 , n=20), the right eye received @entity1949 ( @entity1949 ) alone. In the second group (DA- @entity1949 , n=16), the deprived eye of 7-day-old @entity95 received four intravitreal injections of 20 microg @entity935 every 5 days. In the third group (saline- @entity1949 , n=16), the deprived eye received saline injections with the same schedule. The contralateral eye remained untreated as a control. At the end of the 8-week deprivation period, the effects of DA on @entity2516 , corneal curvature and ocular dimensions were assessed by streak retinoscopy, keratometry and A-scan ultrasonography, respectively. RESULTS: Eight weeks of @entity1714 induced a myopic shift of -2.70+/-0.87 D (n=20) in treated eyes compared with @entity735 . The major structural correlate of the @entity1714 appeared to be elongation of the vitreous chamber (0.7+/-0.3 mm, n=20) and axial elongation (0.9+/-0.3 mm, n=20), respectively. Repeated intravitreal injections of DA fully prevented the myopic shift (-0.06+/-0.37 D), elongation of the vitreous chamber (0.1+/-0.3 mm, n=16) and axial elongation (0.3+/-0.2 mm, n=16) due to lid suture, whereas saline injections had slight effect. CONCLUSIONS: @entity1949 by suturing eyelids is an effective technique to induce a significant myopic shift, vitreous chamber and axial elongation in @entity95 as a model of @entity1714 development. These changes associated with @entity1949 were retarded by intravitreal injections of DA.
