All-cause mortality by age and gender based on coronary artery XXXX scores.

@entity1 @entity65 @entity460
AIMS: Although coronary artery @entity460 (CAC) has been established as a robust tool for predicting total mortality during intermediate follow-up, less is known about the long-term predictive value of CAC. METHODS AND RESULTS: This study included 13 092 asymptomatic @entity1 without known @entity65 who underwent a clinically indicated CAC scan. CAC was categorized as an Agatson score of 0, 1-99, 100-399, and >= 400. We used multivariable Cox proportional hazards to calculate adjusted hazard ratios (HRs) for mortality stratified by age (younger, intermediate, or older) and gender. The mean age of @entity1 was 58    11 years and 67% were @entity1 . During a median follow-up of 11.0    3.2 years, there were 522 deaths (4.0%). Compared with CAC = 0, increasing CAC was associated with higher mortality rate: 1-99 [HR: 1.5, 95% confidence interval (95% CI): 1.1-2.1]; 100-399 (HR: 1.8, 95% CI: 1.3-2.5); >= 400 (HR: 2.6, 95% CI: 1.9-3.6). Relative risk according to CAC category did not differ between genders. The strongest associations between CAC and mortality were observed for young and intermediate age @entity1 . Nonetheless, the mortality rate of the older @entity1 with CAC = 0 was far lower than that of the general US population. CAC was more predictive of long-term (15 years) than intermediate-term (5 years) mortality for @entity1 [receiver operator characteristics (ROC): 0.723 vs. 0.702] and @entity1 (ROC: 0.69 vs. 0.65). CONCLUSION: CAC is strongly associated with the long-term risk of mortality in young- and middle-aged @entity1 and @entity1 . In older @entity1 , the long-term risk stratification of CAC is lower, due principally to increased mortality rate in @entity1 with low @entity460 scores; however, even in the older @entity1 , those with absent or low CAC are at a significantly lower risk of mortality compared with the general population.
