The role of the XXXX on the @entity4044 facilitation effect of fear extinction as assessed with fear-potentiated @entity427 .

@entity4286 @entity27202 @entity35 @entity4044 @entity2414 @entity427 @entity12689
RATIONALE: @entity4044 extract, @entity12689 , is widely used as herbal supplements throughout Western society. It has been used in the treatment of various common geriatric complaints including @entity2414 . Our previous study has shown that acute systemic administration of @entity12689 enhanced extinction of fear-potentiated @entity427 (FPS) in @entity35 . Little is known about the behavioral effects of hippocampally administered @entity12689 on the extinction of FPS. OBJECTIVE: The current study was performed to evaluate the involvement of the @entity27202 ( @entity27202 ) in the @entity12689 facilitation effect on the extinction of FPS. METHODS AND RESULT: Male adult SD @entity35 were used. @entity12689 (28  ng/side, bilaterally) was infused into @entity27202 bilaterally 10  min prior to extinction training. Animals were then tested for FPS 24  h later. Results showed that intra-hippocampal infusion of @entity12689 prior to extinction training facilitated extinction, which was not due to impairments of expression of conditioned fear. Intra-hippocampal injection of ERK1/2 inhibitor @entity4286 partially attenuates the above @entity12689 effect. Therefore, acute @entity12689 administration modulated extinction of conditioned fear, which might be mediated by more than one signal cascade. CONCLUSIONS: These results suggest that @entity27202 may participate in the facilitation effect of @entity12689 on the extinction of conditioned fear. In addition to ERK1/2, another signal cascade may also be involved in the @entity12689 facilitation effect on extinction.
