Diagnostic Performance of Whole-Body MRI as a Tool for Cancer Screening in XXXX With Genetic Cancer-Predisposing Conditions.

@entity1 @entity5 @entity3557
OBJECTIVE: @entity1 with @entity5 -predisposing conditions are at increased risk to develop and die of @entity5 . Limited data exist on the utility of whole-body MRI as a @entity5 screening tool in @entity1 . In this study, we examined the diagnostic performance of whole-body MRI as a mechanism of @entity5 surveillance for @entity1 at increased genetic risk for @entity5 . MATERIALS AND METHODS: Twenty-four @entity1 (six @entity1 and 18 @entity1 ) with a mean age of 11.2 years (range, 2.1-18.2 years) underwent 50 unenhanced whole-body MRI examinations over a 5-year period. Scans were retrospectively reviewed and assessed for image quality; sequences performed; and the presence of osseous, soft-tissue, or solid organ abnormalities. Findings suggestive of a @entity5 were stratified by risk as low (< 20% chance for @entity5 ), moderate (20-80%), or high (> 80%). MRI findings were correlated with medical records, biopsy results, or additional follow-up imaging; biopsy and follow-up were considered as the reference standards. RESULTS: Forty-eight of 50 (96%) examinations were of very good quality. Nine findings suspicious for @entity5 were identified, including two high-risk, two moderate-risk, and five low-risk lesions. One high-risk lesion was proven by biopsy to be a @entity3557 , with the remaining lesions deemed nonmalignant. The sensitivity of whole-body MRI was 100%; specificity, 94%; positive predictive value, 25%; and negative predictive value (NPV), 100%. CONCLUSION: Unenhanced whole-body MRI is safe and produces excellent images. The high sensitivity, specificity, and NPV make whole-body MRI a valuable @entity5 screening tool in @entity1 with a genetic predisposition for @entity5 .
