Comparison of CRT and CRT-D in XXXX : systematic review of controlled trials.

@entity1 @entity1164 @entity712 @entity204 @entity1002
BACKGROUND: Few studies have directly compared cardiac resynchronisation therapy (CRT) with combined CRT-cardioverter defibrillator therapy (CRT-D) in @entity1 with @entity1002 . We performed a systematic analysis to assess the therapeutic effects of CRT and CRT-D in @entity1 with @entity1002 and @entity712 . METHODS: The Medline database from 1970 to September 2010 was searched. The major outcome examined was the all-cause @entity204 rate. RESULTS: A total of 3404 @entity1 were retrieved from seven studies. Overall, CRT-D reduced all-cause @entity204 by 8.42% compared with CRT [odds ratio (OR) 0.52, 95% confidence interval (CI) 0.43-0.81, P=0.001, I(2)=63.9%]. An increased benefit was seen after extended follow-up (after 1 year, OR 0.56, CI 0.41-0.77, P=0.0004, I(2)=64.9%), but not after relatively short follow-up (within 1 year, P=0.11). Results from other endpoints examined, such as @entity204 from @entity1164 and @entity712 , also supported CRT-D treatment. CONCLUSIONS: Evidence from current randomised and non-randomised trials demonstrates some superiorities of CRT-D over CRT, such as all-cause @entity204 rate after one-year follow-up and @entity204 , in @entity1 with @entity1002 . However, these findings must be verified in larger, randomised, prospective trials, including with extended @entity1 follow-up.
