Long-term outcomes of fertility-sparing treatment of atypical polypoid adenomyoma with XXXX .

@entity1 @entity11796 @entity3443 @entity1204
PURPOSE: Our objective was to analyze the long-term oncologic outcomes of fertility-preserving hormonal treatment with @entity11796 ( @entity3443 ) in @entity1 with APA. METHODS: In a retrospective chart review, we identified @entity1 with APA who were treated with @entity3443 for fertility preservation at our hospital between 2001 and 2011. Eighteen @entity1 with histologically diagnosed APA were identified. Clinical data including treatment, obstetrical, and oncologic outcomes were recorded. RESULTS: The mean observation period was 77.6 months (median 73.5, range 22-142), and the mean age was 33.6 years. Four @entity1 also developed well-differentiated @entity1204 . After the treatment, 14 @entity1 (77.8 %) achieved either a complete response or partial response. Eight @entity1 experienced recurrence, while four experienced persistent disease. Ten @entity1 (55.6 %) eventually underwent hysterectomy. The median time to hysterectomy was 40.3 months (range 24-68). Nine @entity1 progressed to @entity1204 , and one experienced persistent APA. Among younger @entity1 (<35 years of age), four out of five @entity1 who were married could have @entity1 . Seven @entity1 (38.9 %) showed no evidence of the disease during the observation period (median 60 months, range 22-117 months). No one died because of the disease during the observation period. CONCLUSIONS: @entity3443 yields a high response rate in APA, and if only younger @entity1 are considered, a favorable pregnancy rate can be obtained. However, because recurrence rate is high, long-term follow-up under supervision of a trained gynecologic oncologist is required. To confirm @entity3443 's utility, multi-center collaboration would be warranted.
