Effect of beta 1-selective and nonselective beta blockade on blood pressure relative to physical performance in @entity1 with systemic XXXX .

@entity1 @entity1169 @entity101 @entity880 @entity2165
Eleven physically active @entity1 with systemic @entity101 were studied after 5 weeks of treatment with placebo, @entity2165 or @entity1169 . A double-blind, crossover randomized design was used. Blood pressure (BP), heart rate (HR), physical performance capacity, rate of perceived exertion and blood @entity880 concentrations were measured during rest, exercise to exhaustion and postexercise, at 8 and 24 hours after intake of the last dose. Blood pressure at rest and during exercise was similarly decreased with both drugs (8 and 24 hours), and there was no difference between 8 and 24 hours with any of the treatments. Heart rate (8 hours) was decreased similarly by both drugs, but after 24 hours, HR at increased workloads (above 120 watts) was higher with @entity2165 compared with @entity1169 . Maximal HR was lower with @entity1169 than @entity2165 at both 8 and 24 hours. Maximal exercise loads (8 and 24 hours) were 231 and 232 watts with placebo, 211 and 212 with @entity1169 and 228 and 227 with @entity2165 . That is, maximal workload was decreased with @entity1169 compared with placebo and @entity2165 at both 8 and 24 hours. No difference was found between placebo and @entity2165 at either 8 or 24 hours. The rate of perceived exertion values were higher with @entity1169 than @entity2165 . Blood @entity880 concentrations did not differ according to treatments. The results indicate that @entity2165 , when given in a dose that decreases resting and exercise BP to the same extent as @entity1169 , limits physical performance less than @entity1169 .
