Effects of @entity11745 agonists on the expression of developmental follicular anti  -mullerian hormone in varying follicular stages in cyclic XXXX in  vivo.

@entity4397 @entity19 @entity11493 @entity11745
UNASSIGNED: Gonadotrophin  -releasing hormone ( @entity11745 ) agonists ( @entity4397 ) have been widely used to induce a state of downregulation for in  vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of @entity4397 on the expression of anti  -mullerian hormone ( @entity11493 ) by follicles in varying stages in  vivo remain to be fully elucidated. In the present study 84  cyclic @entity19 were randomly divided equally into four @entity4397 groups and three cyclic @entity19 were used as a control group. The expression levels of @entity11493 in follicles of varying stages between days  0 and  7 following @entity4397 administration were quantified using immunohistochemistry. The expression of @entity11493 in follicles at various stages revealed dynamic changes during the process of downregulation. @entity11493 in primary follicles initially increased and then decreased gradually. In small and large preantral follicles and in granulosa cells (GCs) surrounding the oocyte of small antral follicles, the expression of @entity11493 began to increase on day  1, was attenuated on day  2, and then increased to a peak. The expression levels of @entity11493 in the GCs surrounding the basement membrane, in contrast to the GCs surrounding the oocyte, were significantly lower and did not increase on day  1. In all stages of follicles, the expression of @entity11493 declined gradually between the peak level and last day of downregulation. On day  7, the varying follicular stages all expressed lower levels of @entity11493 than on day  0. This decrease was more prominent in the higher dose groups, compared with the lower dose groups. In conclusion, @entity4397 was observed to induce time  -dependent changes in the expression of @entity11493 at varying follicular stages, which occurred in a dose  -dependent manner.
