A pilot study on hypothalamo-pituitary-adrenocortical @entity2270 in XXXX .

@entity1 @entity459 @entity1369 @entity535 @entity619 @entity1636 @entity701 @entity460 @entity2270 @entity461
BACKGROUND _ OBJECTIVE: Parathormone ( @entity461 ) and @entity460 , both have been shown to stimulate adrenal steroidogenesis in animal models and in vitro experiments. This is attributed to structural similarity between 15-25 @entity535 region of the @entity461 ( @entity461 ) and 1-11 @entity535 region of adrenocorticotropin (ACTH). However, there are no in vivo @entity1 data regarding the effect of PTHcalcium @entity2270 on adrenocortical function. METHODS: Ten @entity1 with @entity459 underwent evaluation for @entity701 dynamics including 0800 h and 2000 h plasma @entity701 on day 1, @entity701 response to insulin induced hypoglycaemia (IIH) on day 2, and 1 mg overnight @entity619 suppression test (ONDST) on day 4. Serum @entity1369 was also measured at 0800 h in fasting state on salt ad libitum for three days. These parameters were repeated 3 months after curative parathyroidectomy. RESULTS: Basal plasma @entity701 level at 0800 h and 2000 h were within upper normal range and loss of circadian rhythm in @entity701 secretion was observed in half and forty per cent of @entity1 had nonsuppressibility with ONDST. The defined peak @entity701 response to insulin induced hypoglycaemia (>550 nmol/l) was achieved in all and nearly one third of @entity1 had exaggerated response (>2000 nmol/l). After curative parathyroidectomy, the abnormalities in circadian rhythm and non-suppressibility with ONDST continued to prevail in 40 per cent of @entity1 . The peak @entity701 response to IIH showed a decrement but remained higher than normal. No correlation was observed between circulating @entity461 and @entity460 with @entity701 levels. Serum @entity1369 was in upper normal range pre - and postoperatively, though it decreased postoperatively, but it could not attain a statistical significance (p = 0.5). INTERPRETATION _ CONCLUSION: @entity1636 in @entity459 do occur, however these are inconsistent and do not recover in majority of @entity1 even after 3 months of curative parathyroidectomy.
