Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning XXXX .

@entity1 @entity788 @entity5 @entity3
BACKGROUND: Sporadic malignant non-functioning @entity788 (NF-PETs) are an important subset of @entity788 . The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up. @entity1 AND METHODS: From 1988 to 2009, 51 @entity1 were treated for sporadic malignant NF-PETs. Forty-one @entity1 who underwent @entity5 resection were retrospectively attributed according to the date of the initial diagnosis, group 1: 1988-1999 vs. group 2: 2000-2009. RESULTS: Cross-sectional imaging led to positive prediction of NF-PETs in all @entity1 . Curative resection was achieved in 76%. Synchronous metastases were present in 56% with a positive prediction of 43%. In group 1, the mean reported CT-determined @entity5 size was 56 vs. 54  mm in group 2 (p   =   0.89). Synchronous metastases were present in 61% in group 1 vs. 57% (p   =   0.99) in group 2. Metachronous metastases were recorded in 39% in group 1 vs. 43% (p   =   0.84) in group 2. The mean interval from initial resection to diagnosis of @entity3 was significantly shorter (p   =   0.01) in @entity1 from group 1 (14 vs. 61  months). Cumulative 5- and 10-year survival rates were 77% and 72% in group 1 vs. a 5-year survival rate of 66% in group 2. CONCLUSION: So far, improved CT-based imaging has no impact on earlier detection of initial synchronous metastases in sporadic malignant NF-PETs, while metachronous metastases are detected earlier.
