The Adjuvant Activity of Epimedium Polysaccharide-Propolis XXXX Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in @entity19 .

@entity19317 @entity650 @entity19 @entity379 @entity18723
UNASSIGNED: Objectives. The adjuvant activity of Epimedium polysaccharide-propolis @entity19317 liposome (EPL) was investigated in vitro and in vivo. Methods. In vitro, the effects of EPL at different concentrations on splenic lymphocytes proliferation and mRNA expression of @entity379 and @entity650 were determined. In vivo, the adjuvant activities of EPL, EP, and mineral oil were compared in BALB/c @entity19 through vaccination with inactivated @entity18723 ( @entity18723 ) vaccine. Results. In vitro, EPL promoted lymphocytes proliferation and increased the mRNA expression of @entity379 and @entity650 , and the effect was significantly better than EP at all concentrations. In vivo, EPL significantly promoted the lymphocytes proliferation and the secretion of cytokines and improved the killing activity of NK cells, PCV2-specific antibody titers, and the proportion of T-cell subgroups. The effects of EPL were significantly better than EP and oil adjuvant at most time points. Conclusion. EPL could significantly improve both @entity18723 -specific cellular and humoral immune responses, and its medium dose had the best efficacy. Therefore, EPL would be exploited in an effective immune adjuvant for inactivated @entity18723 vaccine.
