The management of XXXX and @entity227 .

@entity1 @entity2847 @entity227 @entity2013 @entity5 @entity4776 @entity2124 @entity652
The indications and results of transsphenoidal surgery for pituitary @entity652 are analysed. The advantages and disadvantages of @entity2847 and radiotherapy are considered. Transsphenoidal surgery does not damage pre-existing pituitary function. It produces excellent results in micro and mesoadenomas, curing about 70-80% of @entity1 irrespective whether the @entity5 produces ACTH, prolactin or @entity2124 . Moreover there is a very small relapse rate. Macroadenomas of non-functioning type are also well treated by transphenoidal surgery, with a small recurrence rate as judged by CT scan follow-up. But macroadenomas secreting prolactin or @entity2124 are less effectively treated by transsphenoidal surgery, only about 40% being cured. Invasive macro @entity2013 are not helped by surgery and should be treated with @entity2847 and radiotherapy. Radiotherapy should be used sparingly and has inevitable complications. Post-operative delayed @entity227 is caused either by recurrent @entity5 or radiotherapy. There is no good evidence to support the secondary @entity4776 as a cause of such delayed @entity227 .
