The risks and benefits of XXXX replacement therapy: Leisure World.

@entity1 @entity172 @entity1204 @entity64 @entity174 @entity604 @entity170 @entity299 @entity173 @entity195 @entity2524 @entity741 @entity583 @entity204 @entity65
A @entity1 spends about one-third of her life in her postmenopausal years. Some @entity1 supplement this period of decreased @entity172 production with @entity172 replacement therapy (ERT). Many epidemiologic studies have examined the long-term effect of postmenopausal @entity172 deprivation and of ERT. Since the 1970s, we have evaluated the risks and benefits of ERT in one population of older @entity1 in the California retirement community of Leisure World. ERT is the most effective method for preventing @entity604 and @entity174 in postmenopausal @entity1 . In Leisure World, ERT reduced the risk of @entity173 by about 50%. The effect is greatest in longterm users, but may be lost after discontinuation. @entity170 affects the bones of the jaws as well as other skeletal bones. @entity604 in the jaws may result in @entity2524 . In Leisure World, @entity172 users have retained more natural teeth than nonusers. @entity65 is the leading cause of hospitalization and @entity204 in @entity1 . In Leisure World, ERT reduced the risk of fatal and nonfatal @entity583 , @entity741 , other @entity299 , and @entity64 by 20-40%. The reduction is greatest in long-term and/or current users. ERT is effective in @entity1 with and without @entity65 risk factors. One of the most feared aspects of aging is @entity195 . In Leisure World, @entity1 who had used ERT had a reduced risk of @entity195 . Risk decreased with increasing duration of use. @entity172 use, however, is not without risk. Unopposed @entity172 increases risk of @entity1204 . Risk increases with increasing years of use and remains high after discontinuation.(ABSTRACT TRUNCATED AT 250 WORDS)
