[A quantitative evaluation of spinocerebellar degeneration by an acoustic analysis--the effect of XXXX on @entity1 with @entity164 ].

@entity1 @entity61156 @entity164 @entity2055
A clinical evaluation of 10 @entity1 with @entity164 ( @entity164 ) was performed by using an acoustic analysis soft (SoundScope, GW Instruments Inc) before and on 4 weeks of treatment of @entity61156 (TH). A rapid repetitive monosyllable/ka/was recorded as the samples were analyzed in a computer. The repetition period (ms) and the maximum intensity (volt) was measured from the sound spectrogram and the amplitude envelope for each speech wave. Three acoustic parameters, which were mean of period (ms) (m-P), coefficient of variation of period (%) (CV-P), and coefficient of variation of amplitude (%) (CV-A), were calculated according to Ishida's acoustic analysis method. The average age in this study group was 52.4 +/- 11.4 years (32-73 years), the mean scores of @entity2055 ( @entity2055 ) was 35.0 +/- 18.6. Significant correlation was shown between CV-A and @entity2055 scores before therapy (p < 0.05). CV-P was decreased significantly (p < 0.05) from 10.9 +/- 0.12% to 9.2 +/- 0.26% after TH, and its degree of decrement correlated with @entity2055 scores (p < 0.05), which means a greater effect of TH is expected in @entity1 with milder symptoms. @entity2055 scores did not change with a statistical significance. TH was shown to be effective on the ataxic speech of @entity1 with @entity164 by quantitative methods. The acoustic analysis used in this study is a sensitive and objective evaluation method for following up the clinical severity of @entity164 and judging effectiveness of a drug.
