Primary genitourinary XXXX : Epidemiology and @entity66 in a large population-based cohort.

@entity1 @entity66 @entity5 @entity395 @entity320
BACKGROUND: Primary genitourinary (GU) @entity320 is a @entity395 , which is poorly characterized. OBJECTIVE: To examine clinical characteristics and survival outcomes of @entity320 among @entity1 and @entity1 . DESIGN, SETTING, AND @entity1 : Retrospective study using the Surveillance, Epidemiology, and End Results database (1973-2010) was used to identify @entity320 cases by @entity5 site and histology codes. We examined associations of @entity320 with demographic, clinical, and pathologic characteristics, as well as @entity66 ( @entity66 ). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: @entity66 was calculated using the Kaplan-Meier method. Cox-proportional hazard models were used to calculate hazard ratios and 95% CI for factors associated with worse @entity66 . RESULTS AND LIMITATIONS: A total of 1,586 histologically confirmed cases of @entity320 were identified with a median age of 66.1 years (IQR: 55-80). Incidence of @entity320 was 0.2cases/million among @entity1 and 1.80cases/million among @entity1 . Overall, 60.1% of @entity1 had localized disease at presentation and 90.5% of @entity1 had @entity5 -directed surgery. @entity1 with @entity320 had the worst 5- and 10-year @entity66 (39% and 29%, respectively). @entity1 with @entity320 had worse 5- and 10-year @entity66 compared to @entity1 with @entity320 . In multivariate analysis, decreased survival was associated with increasing age, distant stage, and lymph node involvement. Results are limited by the lack of standardized staging for @entity320 and the retrospective design of our study. CONCLUSIONS: @entity1 with @entity320 present with advanced stage and have a poor prognosis. @entity1 have worse @entity66 compared to @entity1 . @entity66 is negatively associated with advanced age at diagnosis, higher stage, and lymph node involvement. @entity1 SUMMARY: Clinicians and @entity1 must be aware of the poor disease-specific outcomes associated with @entity320 . Most importantly, @entity1 fare worse than @entity1 and @entity320 have worse outcomes compared to cutaneous @entity320 .
