Anxiolytic activity of XXXX Linn. in @entity19 as experimental models of anxiety.

@entity19 @entity3175 @entity146 @entity73014
OBJECTIVE: The aim of the present work was to evaluate the anxiolytic effect of an ethanolic extract of @entity73014 Linn. in @entity19 . MATERIALS AND METHODS: The elevated plus maze test (EPMT), light and dark test (L and DT) and open field test (OFT) were used to assess the anxiolytic activity of the ethanolic extract of @entity73014 Linn. in @entity19 . In addition, aggressive @entity146 was also assessed by @entity146 ( @entity146 ) and rota rod test (RRT). @entity3175 1 mg/kg served as a standard anxiolytic drug, administered orally. RESULTS: The ethanolic extract of @entity73014 (100 and 200 mg/kg, p.o.) significantly increased the percentage of time spent and number of entries in open arm in EPMT. In L and DT, the extract produced significant increase in time spent, number of crossing and decrease in the duration of immobility in light box. In OFT, the extract showed significant increase in number of rearings, assisted rearings and number of square crossed, all of which are demonstrations of exploratory behavior. In @entity146 , @entity73014 extract attenuated @entity146 related to anxiolytic activity, such as number of vocalization, leaps, rearing, biting/attacks and facing each other in paired @entity19 . Furthermore, the extract produced skeletal muscle relaxant effect assessed by RRT. CONCLUSION: The results of the present study suggest that an ethanolic extract of @entity73014 may possess anxiolytic activity and provide a scientific evidence for its traditional claim.
