Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L XXXX .

@entity3038 @entity632 @entity1214 @entity15436 @entity5 @entity10822 @entity26 @entity11256 @entity519 @entity35 @entity4095
Tissue @entity26 tensions were measured in the @entity35 9L @entity3038 under conditions of normal air breathing or @entity15436 breathing and after intravenous administration of a hemoglobin solution with air breathing or @entity15436 breathing. Administration of the hemoglobin decreased the level of @entity519 in the @entity5 . Treatment of the animals with the antiangiogenic combination of @entity10822 and @entity1214 also increased @entity5 oxygenation compared with untreated controls. Treatment with the antiangiogenic agents along with administration of the hemoglobin solution/ @entity15436 breathing decreased the @entity519 fraction (% @entity4095 readings < or = 5 mmHg) from 71 % to 30%. Treatment of the @entity5 -bearing animals with BCNU or @entity632 modestly reduced @entity519 in the @entity5 , while treatment with fractionated radiation markedly increased @entity519 in the @entity5 . @entity5 growth delay was used to assess the response of the subcutaneous @entity5 to the various treatment combinations. There was a strong correlation between increased therapeutic response and @entity5 . @entity5 growth delay from BCNU increased from 5.3 days to 16.4 days with @entity10822 /- @entity1214 /hemoglobin solution/ @entity15436 . Similarly, the @entity5 growth delay from @entity632 increased from 3.9 days to 17.0 days with @entity10822 / @entity1214 /hemoglobin solution/ @entity15436 . Finally, the @entity5 growth delay from fractionated radiation increased from 4.8 days to 13.3 days with @entity10822 / @entity1214 /hemoglobin solution/ @entity15436 . When @entity11256 was added to the complete radiation regimen, the @entity5 growth delay increased further to 20.5 days. These data show that the addition of non-toxic agents that increase @entity5 oxygenation to cytotoxic therapies can markedly increase therapeutic response.
