Angiotensin-(1-7) Improves XXXX by Regulating the @entity5704 Inflammasome via Redox Balance Modulation.

@entity5568 @entity82 @entity72115 @entity5704 @entity16228 @entity2178 @entity26 @entity1356 @entity2041 @entity4100 @entity1110 @entity6172 @entity13791 @entity1575 @entity2939 @entity7741
AIMS: @entity2178 ( @entity2178 ) aggravates @entity1575 by inducing @entity1110 oxidase (NOX)-dependent oxidative stress. @entity72115 [ @entity7741 -(1-7)], which counter-regulates @entity2178 , has been evidenced to protect against @entity1575 . The NOD-like receptor family pyrin domain containing 3 ( @entity5704 ) inflammasome, being activated by reactive @entity26 species (ROS), is identified as a novel mechanism of liver @entity82 . However, whether the @entity5704 inflammasome involves in regulation of @entity2178 -induced @entity1575 remains unclear. This study investigates the different effects of the @entity2178 and @entity7741 -(1-7) on collagen synthesis by regulating the @entity5704 inflammasome/Smad pathway via redox balance modulation. RESULTS: In vivo, @entity7741 -(1-7) improved bile duct ligation-induced @entity1575 , reduced @entity5568 content, protein levels of @entity16228 , and the @entity5704 inflammasome, whereas it increased @entity2041 ( @entity6172 ) and @entity13791 ( @entity13791 ) antioxidant response element (ARE). In vitro, @entity7741 II treatment elevated @entity16228 protein expression and ROS production in hepatic stellate cells (HSCs), whereas it inhibited @entity6172 and @entity13791 -ARE, resulting in the activation of the @entity5704 inflammasome in the mitochondria of HSCs. @entity5704 depletion inhibited @entity2178 -induced collagen synthesis. Furthermore, @entity2178 increased @entity5704 and @entity1356 levels by activating the @entity2939 ( @entity2939 )/ @entity4100 /NF-kB pathway. Treatment with antioxidants, @entity16228 small interference RNA (siRNA), or @entity13791 activator inhibited @entity2178 -induced @entity5704 inflammasome activation and collagen synthesis. In contrast, the action of @entity7741 -(1-7) opposed the effects of @entity2178 . Innovation and Conclusions: @entity7741 -(1-7) improved liver @entity82 by regulating @entity5704 inflammasome activation induced by @entity7741 II-mediated ROS via redox balance modulation. Antioxid. Redox Signal. 00, 000-000.
