Thirst and vasopressin release in the @entity235 : an osmoreceptor or XXXX receptor mechanism?

@entity1133 @entity5463 @entity1219 @entity235 @entity1372 @entity969 @entity4372 @entity413
The effects of intravenous infusion of hypertonic @entity1219 , @entity969 , @entity413 , @entity1133 , or isotonic @entity1219 solution on thirst and plasma @entity5463 concentration (AVP) were studied in five conscious @entity235 . The changes in osmolality and @entity1372 concentration of plasma and cerebrospinal fluid (CSF) were measured at the threshold of drinking, or after 45 min if no drinking occurred. @entity4372 @entity1219 and @entity969 stimulated drinking in all @entity235 and significantly elevated plasma AVP. Equally hypertonic @entity413 , @entity1133 , or isotonic @entity1219 failed to stimulate any drinking or vasopressin secretion. All hypertonic solutions caused significant and similar increases in the osmolality and @entity1372 concentration of CSF. Plasma osmolality was increased by the hypertonic solutions. Plasma @entity1372 was increased by hypertonic @entity1219 , decreased by @entity969 and @entity413 , and not changed by @entity1133 . Isotonic @entity1219 had no effect on either plasma or CSF composition. These data are not consistent with either a @entity1372 or an osmoreceptor mechanism located within the blood-brain barrier (BBB) or with a peripheral @entity1372 receptor mechanism. An intracranial osmoreceptor located on the blood side of the BBB is proposed to explain these results.
