Polymorphism of 270 A > G in XXXX is Associated with Lower Ankle-Brachial Index in a Taiwanese Population.

@entity1 @entity64 @entity30296 @entity3657 @entity30293 @entity2998 @entity453 @entity583
AIMS: The single nucleotide polymorphism (SNP) @entity30296 of @entity30293 has been shown to be associated with @entity583 ( @entity583 ), @entity453 and @entity2998 , but it is not clear whether it also plays a role in @entity3657 ( @entity3657 ). The ankle-brachial index (ABI) is often used as a non-invasive measure of @entity3657 ; therefore, the aim of this study was to test for a relationship between the SNP @entity30296 and ABI. METHODS: A total of 537 high-risk subjects with a family history of @entity583 or @entity64 completed a health survey, including a physical examination, blood test and measurement of ABI. Among them, 523 subjects had the genotypes. Association analyses between the genotype of @entity30293 and ABI were performed by multiple linear and logistic regressions with adjustment for covariates. RESULTS: We found that the GG genotype is significantly associated with a lower ABI value. For the lowest ABI tertile, the GG genotype had an OR of 2.87 (p =0.018) when compared with the middle ABI tertile, and OR of 2.92 (p =0.015) when compared to the highest ABI tertile. @entity1 with the GG genotype had a lower ABI value than @entity1 with the same genotype (p =0.012). Accordingly, @entity1 carrying this GG risk genotype may have a higher risk for @entity3657 . CONCLUSION: Our findings provide additional evidence that support the genetic effect of @entity30293 on diverse cardiovascular phenotypes.
