Redox proteomic investigation of XXXX -induced @entity1560 .

@entity1718 @entity66 @entity1560 @entity71754 @entity8595 @entity803
Pathological levels of @entity66 ( @entity66 ) have been implicated in a broad spectrum of diseases. Carbonylation is an irreversible post translational modification that is considered as a universal indicator of @entity66 . The development of new enrichment techniques coupled with the introduction of highly sensitive mass spectrometers has allowed the identification of carbonylated proteins in biological systems. In this study Deng et  al.(Proteomics 2015, 15, xxx-yyy) utilized one of these methods to isolate and identify carbonylated proteins that are involved in @entity803 -induced @entity1560 . They identified 26 proteins that are targets of @entity66 and most of them were located in the mitochondria. A key carbonylated protein that was identified is long-chain specific @entity8595 dehydrogenase ( @entity71754 ) which has a major role in the b-oxidation of @entity1718 . The researchers concluded that @entity803 -induced @entity1560 is a two-step process which involves lipid overload followed by @entity66 . This article is protected by copyright. All rights reserved.
