Negative Biopsy after Referral for Biopsy-Proven XXXX .

@entity1 @entity308 @entity356
Background/Aims: Repeat endoscopy with biopsy is often performed in @entity1 with previously diagnosed @entity356 to determine further treatment plans. However, biopsy results may differ from the original pathologic report. We reviewed @entity1 who had a negative biopsy after referral for @entity356 . Methods: A total of 116 @entity1 with negative biopsy results after referral for biopsy-proven @entity356 were enrolled. Outside pathology slides were reviewed. Images of the first and second endoscopic examinations were reviewed. We reviewed the clinical history from referral to the final treatment. Results: Eighty-eight @entity1 (76%) arrived with information about the lesion from the referring physician. Among 96 @entity1 with available outside slides, the rate of interobserver variation was 24%. Endoscopy was repeated at our institution; 85 @entity1 (73%) were found to have definite lesions, whereas 31 @entity1 (27%) had indeterminate lesions. In the group with definite lesions, 71% of the lesions were @entity308 in shape. The most common cause of a negative biopsy was mistargeting. In the group with indeterminate lesions, 94% had insufficient information. All @entity1 with adequate follow-up were successfully treated based on the findings in the follow-up endoscopy. Conclusions: A negative biopsy after referral for biopsy-proven @entity356 is mainly caused by mistargeting and insufficient information during the referral.
