Canaloplasty: Three-year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat XXXX .

@entity1 @entity1538 @entity726 @entity231
PURPOSE: To report 3-year results of the safety and efficacy of canaloplasty, a procedure involving circumferential viscodilation and tensioning of the inner wall of Schlemm canal to treat @entity1538 . SETTING: Multicenter surgical sites. DESIGN: Nonrandomized multicenter clinical trial. METHODS: This study comprised adult @entity1538 @entity1 having canaloplasty or combined @entity231 -canaloplasty surgery. Qualifying preoperative intraocular pressures (IOPs) were at least 16 mm Hg with historical IOPs of at least 21 mm Hg. A flexible microcatheter was used to viscodilate the full circumference of the canal and to place a trabecular tensioning suture. Primary outcome measures included IOP, @entity726 medication use, and adverse events. RESULTS: Three years postoperatively, all study eyes (n = 157) had a mean IOP of 15.2 mm Hg    3.5 (SD) and mean @entity726 medication use of 0.8    0.9 compared with a baseline IOP of 23.8    5.0 mm Hg on 1.8    0.9 medications. Eyes with combined @entity231 -canaloplasty surgery had a mean IOP of 13.6    3.6 mm Hg on 0.3    0.5 medications compared with a baseline IOP of 23.5    5.2 mm Hg on 1.5    1.0 medications. Intraocular pressure and medication use results in all eyes were significantly decreased from baseline at every time point (P<.001). Late postoperative complications included @entity231 (12.7%), transient IOP elevation (6.4%), and partial suture extrusion through the trabecular meshwork (0.6%). CONCLUSION: Canaloplasty led to a significant and sustained IOP reduction in adult @entity1 with @entity1538 and had an excellent short- and long-term postoperative safety profile. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.
