The potencies and selectivities of four @entity460 antagonists as inhibitors of uterine contractions in the XXXX in vivo.

@entity1855 @entity4473 @entity3045 @entity3988 @entity591 @entity460 @entity594 @entity35
The potencies of four @entity460 antagonists ( @entity594 , @entity4473 , @entity1855 and @entity3988 ) at inhibiting uterine contractions in vivo have been assessed in the conscious ovariectomized, post-partum @entity35 . Their selectivities for this action, relative to their effects on blood pressure and heart rate, have been compared with @entity3045 . All compounds produced a dose-dependent inhibition of intra-uterine pressure cycles. The rank order of potency was @entity3045 greater than @entity594 greater than @entity3988 = @entity4473 greater than @entity1855 . All compounds produced a dose-dependent fall of mean blood pressure. The rank order of potency was @entity3045 greater than @entity594 greater than @entity4473 greater than @entity1855 greater than @entity3988 . @entity3045 and @entity594 produced a @entity591 , which was very marked with @entity3045 . @entity4473 , @entity1855 and @entity3988 induced a moderate @entity591 at low doses but temporary cessation of heart beat occurred at high doses. @entity594 and @entity3988 , like @entity3045 , exhibited some selectivity for inhibition of uterine contractions relative to their cardiovascular actions. @entity4473 and @entity1855 showed no selectivity for the uterus.
