Wound healing acceleration effect of endemic Ononis species growing in XXXX .

@entity627 @entity1046 @entity233 @entity1489 @entity5318 @entity1543 @entity484
AIM OF THE STUDY: Ononis L. species have been used for healing of wounds, @entity484 and @entity627 , against @entity1489 and lesions and topically used as antiseptic and antimicrobial agent in folk medicine. In the present study, the aqueous and methanolic extracts of three endemic Ononis species growing in @entity233 , including Ononis sessilifolia Bornm., Ononis basiadnata Hub.-Mor. and Ononis macrosperma Hub.-Mor. were assessed for their in vivo wound healing and anti-inflammatory activities. MATERIALS AND METHODS: In vivo wound healing activities of the plants were evaluated by using linear incision and circular excision experimental models subsequently histopathological analysis. The healing potential was comparatively assessed with a reference ointment @entity5318 (  ), which contains 1% extract of Centella asiatica. In vivo inhibitory effect of the extracts on @entity1543 -induced increase in capillary permeability was studied for the assessment of anti-inflammatory activity. RESULTS: The aqueous and ethanolic extracts of the aerial parts of O. macrosperma demonstrated the highest activity in both wound models and significant anti-inflammatory activity in @entity1543 -induced increase in capillary permeability test. Furthermore, ethanolic extract of the aerial parts of O. sessilifolia showed anti-inflammatory effect but was devoid of wound healing activity. The rest of the species did not show remarkable wound healing effect. @entity1046 fraction of O. macrosperma ethanolic extract demonstrated significant but reduced wound healing activity, which revealed a possible combined effect. The results of histopathological examination supported the outcome of linear incision and circular excision wound models. CONCLUSION: The experimental study revealed that the aerial parts of O. macrosperma display remarkable wound healing and anti-inflammatory activities.
