Hyperfractionated accelerated radiotherapy for T1,2 XXXX . Consideration of time-dose factors.

@entity5 @entity1 @entity7617 @entity189
BACKGROUND AND PURPOSE: Hyperfractionated accelerated radiotherapy without a split (AF) has been performed to improve the local control probability of early glottic @entity189 since 1990 in the authors' institution. Here, they report their experience treating early @entity5 @entity1 with AF in a single institution who have a long follow-up period. @entity1 AND METHODS: 131 T1 N0 M0 @entity5 were treated with @entity7617 ( @entity7617 ) from 1984 to 1989 and with AF since 1990. @entity7617 consisted of five daily fractions of 2 Gy per week, to a total dose of 64 Gy. AF consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, to a total dose of 55 or 58.5 Gy. RESULTS: The 5-year local control probability for T1 @entity5 was 94% with 58.5 Gy and 87% with 55 Gy of AF, whereas it amounted to 80% with @entity7617 . For T2 @entity5 , it was 56% with 58.5 Gy and 68% with 55 Gy of AF, whereas it amounted to 64% with @entity7617 . The data of T2 should be evaluated with caution due to the small number of @entity1 . @entity1 with AF had more severe mucosal reactions but no severe late reactions. CONCLUSION: AF significantly improved the local control rates for T1 @entity5 .
