[Inhibitive effect of @entity21243 on the invasion and XXXX of @entity43 cells HO-8910PM].

@entity43 @entity6027 @entity1476 @entity98 @entity3 @entity1495 @entity21243
OBJECTIVE: To study the effects of @entity21243 (UA) on the invasion and @entity3 of @entity43 cell HO-8910PM and its underlying mechanism. METHODS: @entity98 assay was performed to examine the effects of UA on the proliferation of @entity43 cells HO-8910PM in vitro. The effects of UA on the invasion and migration of HO-8910PM were evaluated using Transwell chambers attached with @entity6027 filters and reconstituted basement membrane. Gelatin zymography was performed to detect the activity of gelatinase in the HO-8910PM cells. The expressions of @entity1476 and @entity1495 in the HO-8910PM cells were measured by Western blot. RESULTS: UA inhibited the proliferation of HO-8910PM cells in a time- and dose-dependent manner. There was a statistically significant difference in the invasion and migration of HO-8910PM cells between the UA treated cells and the controls (P < 0.01, P < 0.05). UA inhibited the activity of gelatinase of the treated cells. CONCLUSION: UA downregulated the expressions of @entity1476 and @entity1495 . UA inhibits the invasion and @entity3 of HO-8910PM cells, probably through inhibiting the activity of gelatinase and the expressions of @entity1476 and @entity1495 .
