XXXX in acute renal failure.

@entity851 @entity4295 @entity63 @entity177 @entity2135 @entity35 @entity14023 @entity73258 @entity7814
The @entity851 in acute @entity177 . Recovery from @entity4295 ( @entity4295 ) is accelerated by @entity2135 therapy. Furthermore, the local renal growth hormone- @entity2135 system may participate in the natural repair. We examined the @entity2135 system in @entity35 kidneys subjected to 60 minute @entity63 compared to sham operated controls. Two days after injury, @entity14023 mRNA and @entity2135 mRNA levels fell approximately 9 to 33% of control values. This was associated with a reduction in kidney immunoreactive @entity2135 levels. In contrast, @entity7814 mRNA abundance was unchanged. However, plasma membrane @entity7814 binding on day 2 and day 7 was near double the control values (P < 0.01). Scatchard analysis revealed a near twofold increase in receptor number. Since receptor mRNA levels were unchanged, this implies receptor protein up-regulation. In contrast to unchanged @entity7814 mRNA levels, the abundance of mRNA levels of @entity73258 fell approximately 14 to 62% of control levels day 2 after injury (P < 0.05), suggesting reduced IGFBP production. Thus, the renal response to @entity4295 , namely, low IGFBP mRNA levels and high @entity7814 number, may function to increase @entity2135 bioavailability and thereby enhance the reparative actions of local and circulating @entity2135 in @entity4295 .
