Involvement of XXXX in acute coronary syndromes assessed by levels of high-sensitivity C-reactive protein, matrix metalloproteinase-9 and soluble @entity4725 .

@entity1 @entity32 @entity1187 @entity379 @entity453 @entity741 @entity1495 @entity4725 @entity731 @entity2071
OBJECTIVES: Inflammation is important in the development of @entity731 . Matrix metalloproteinases (MMPs) and @entity379 which participate in collagen degradation are pathological factors in plaque vulnerability as an important mechanism underlying @entity1187 . This study investigated whether @entity32 is related to the onset of @entity1187 . METHODS: This study included 56 @entity1 with @entity1187 (ACS group), 104 @entity1 with chronic @entity453 (S group), and 38 control subjects with no evidence of @entity741 (C group). High-sensitivity C-reactive protein (hs-CRP), @entity1495 , and @entity379 were measured in peripheral blood samples. Soluble adhesion molecules ( @entity4725 , @entity2071 ) were also measured as inflammatory markers. RESULTS: The hs-CRP level was significantly higher in the ACS group (44.5 mg/l) than in the S group (2.1 mg/l) and the C group (0.6 mg/l) (p < 0.0001). The @entity1495 level was also significantly higher in the ACS group (333.8 ng/ml) than in the S group (110.8 ng/ml) and the C group (72.0 ng/ml) (p < 0.0001). The @entity4725 level was significantly higher in the ACS group (506.5 ng/ml) than in the C group (448.8 ng/ml) (p < 0.05). The @entity2071 level and the @entity379 level did not differ between the groups. There was a significant positive correlation between the level of hs-CRP and the level of the collagen degradation product @entity1495 (r = 0.52) in all subjects. CONCLUSIONS: These results suggest that plaque destabilized by @entity1495 produced in response to @entity32 participates in the mechanism of @entity1187 .
