Adverse Vascular Risk is Related to XXXX in Older Adults.

@entity1 @entity64 @entity101 @entity6 @entity303 @entity73 @entity955 @entity195 @entity2414 @entity65
BACKGROUND: @entity65 ( @entity65 ) and related risk factors are associated with @entity195 ( @entity195 ). This association is less well-defined in normal cognition (NC) or prodromal @entity195 (mild @entity73 , MCI). OBJECTIVE: Cross-sectionally and longitudinally relate a vascular risk index to cognitive outcomes among elders free of clinical @entity303 . METHODS: 3,117 MCI (74    8 years, 56% female) and 6,603 NC @entity1 (72    8 years, 68% female) were drawn from the National @entity195 Center. A composite measure of vascular risk was defined using the @entity64 ( @entity64 ) score (i.e., age, systolic blood pressure, anti- @entity101 medication, @entity6 , cigarette smoking, @entity65 history, @entity955 ). Ordinary linear regressions and generalized linear mixed models related baseline @entity64 to cross-sectional and longitudinal cognitive outcomes, separately for NC and MCI, adjusting for age, gender, race, education, and follow-up time (in longitudinal models). RESULTS: In NC @entity1 , increasing @entity64 was related to @entity73 , information processing speed, and sequencing abilities (p-values <0.0001) and a worse longitudinal trajectory on all cognitive measures (p-values <0.0001). In MCI, increasing @entity64 correlated with @entity2414 (p = 0.004). In secondary models using an age-excluded @entity64 score, associations persisted in NC @entity1 for global cognition, naming, information processing speed, and sequencing abilities. CONCLUSIONS: An adverse vascular risk profile is associated with worse cognitive trajectory, especially global cognition, naming, and information processing speed, among NC elders. Future studies are needed to understand how effective management of @entity65 and related risk factors can modify @entity73 to identify the ideal timeframe for primary prevention implementation.
