Site-specific @entity172 and progestin regulation of XXXX / @entity24661 and @entity24661 opioid receptor mRNA expression in the female @entity35 limbic hypothalamic system.

@entity172 @entity230 @entity1420 @entity14471 @entity134 @entity1515 @entity35 @entity24661
The distributions of @entity24661 (OFQ/N; also known as @entity24661 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity1515 in female @entity35 through @entity172 and @entity1420 regulation of @entity24661 activity. We studied @entity172 and @entity1420 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity35 were treated with @entity14471 (2 microg) and 26 hours later with oil or @entity1420 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity172 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity1420 treatment did not alter @entity172 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity230 . In the caudal part of the posterodorsal medial amygdala, @entity172 increased OFQ/N mRNA levels, and @entity1420 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity172 and @entity1420 were needed to increase OFQ/N mRNA levels. @entity134 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.
