XXXX alters motor and neurochemical responses to activation of group I metabotropic @entity2227 receptors in the nucleus accumbens in @entity35 in vivo.

@entity1 @entity2227 @entity935 @entity10092 @entity1578 @entity11724 @entity9446 @entity35 @entity99 @entity3263
@entity3263 leads to altered cerebral function and neurological alterations in @entity1 with @entity99 . We studied the effects of @entity3263 in @entity35 on the modulation by group I metabotropic @entity2227 receptors (mGluR) of motor and neurochemical functions in vivo. Locomotion induced by injection of the mGluR agonist @entity11724 into nucleus accumbens was increased in hyperammonemic @entity35 . In control @entity35 @entity11724 increased extracellular @entity935 (ca. 400%) but not @entity2227 . In contrast, in hyperammonemic @entity35 @entity11724 increased extracellular @entity2227 (ca. 600%), while @entity11724 -induced @entity935 increase was reduced. Blocking @entity9446 receptor with CPCCOEt prevented all @entity11724 effects, indicating that this receptor mediates its locomotor and neurochemical effects. Hyperammonemic @entity35 showed increased (32%) mGluR1alpha, but not @entity10092 content in nucleus accumbens. These results show that modulation of locomotor and neurochemical functions by mGluRs in nucleus accumbens is strongly altered in @entity3263 . These alterations may contribute to the neurological alterations in @entity3263 and @entity1578 .
