Development and progression of @entity8 in @entity164 2 @entity6 : the United Kingdom Prospective XXXX (UKPDS 64).

@entity1 @entity8 @entity6 @entity177 @entity164 @entity1011 @entity204 @entity65
BACKGROUND: The progression of @entity8 from diagnosis of @entity164 2 @entity6 has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma @entity1011 or renal replacement therapy (RRT), and @entity204 . METHODS: Using observed and modeled data from 5097 subjects in the UK Prospective @entity6 , we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of @entity204 from all-causes or @entity65 . RESULTS: From diagnosis of @entity6 , progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma @entity1011 (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of @entity6 , the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma @entity1011 or RRT was 0.8%. @entity1 with elevated plasma @entity1011 or RRT had an annual @entity204 rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of @entity65 with increasing @entity8 (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no @entity8 , 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma @entity1011 or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop @entity177 . CONCLUSIONS: The proportion of @entity1 with @entity164 2 @entity6 who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer @entity1 develop macroalbuminuria, but in those who do, the @entity204 rate exceeds the rate of progression to worse @entity8 .
