[Reference value and clinical correlates of soluble XXXX in healthy community-based Chinese population].

@entity8389 @entity1 @entity65
OBJECTIVE: This study was designed to investigate the plasma level of soluble @entity8389 (sST2) and related influencing factors, and establish its reference value in the healthy community-based population in Beijing area of China. METHODS: We measured plasma sST2 level by enzyme-linked immunosorbent assay between March 2012 and August 2012 in 1 334 healthy subjects in communities, including 597 males and 737 females. Empiric and quantile regression methods were used to determine the reference range of plasma sST2. A multiple linear regression model was established to analyze the factors that might affect the level of plasma sST2. RESULTS: Gender is the most important factor affecting the plasma level of sST2 in healthy @entity1 . Plasma level of sST2 is significantly higher in @entity1 than in @entity1 (P < 0.01). Within each age strata, i.e. < 45, 45-54, 55-64, >=  65 years old, the plasma levels of sST2 were significantly higher in @entity1 than age-matched female (all P < 0.01). Age, body mass index (BMI), systolic blood pressure, diastolic blood pressure, and smoking did not affect plasma sST2 level. Reference range of sST2 was 5.7-53.5   g/L for @entity1 and 4.4-42.4   g/L for @entity1 (95% nonparametric reference interval). The one-side upper 95th percentile value of sST2 to discriminate the @entity65 from healthy state was 47.2   g/L for @entity1 and 37.2   g/L for @entity1 . CONCLUSIONS: This study established the normal reference range of plasma sST2 in healthy community-based population. The major influencing factor of sST2 level in healthy population is gender.
