Transcatheter arterial chemoembolization combined with CT-guided percutaneous thermal ablation versus hepatectomy in the treatment of XXXX .

@entity1 @entity157 @entity4831 @entity5
INTRODUCTION: Transcatheter arterial chemoembolization (TACE) plus thermal ablation has been widely used recently in the treatment of @entity157 ( @entity157 ). In this study, we aimed to compare results of the combination of TACE and percutaneous thermal ablation with those of hepatectomy in @entity1 with @entity157 . METHODS: The clinical data of 137 @entity157 @entity1 who sequentially received TACE and computed tomography (CT)-guided percutaneous thermal ablation as an initial curative treatment (combination group) and 148 matched @entity157 @entity1 who received hepatectomy (surgery group) between 2004 and 2011 were collected and analyzed. After TACE, multiphase contrast-enhanced CT was performed to identify the total number of @entity5 as well as @entity4831 deposition in the liver. Survival was calculated by using the Kaplan-Meier method and compared by using the log-rank test. The prognostic factors were assessed with multivariate Cox proportional hazards regression analysis. RESULTS: Of all 285 @entity1 , 225 (79.0  %) had @entity5    <=   5  cm in diameter. In preoperative contrast-enhanced CT or magnetic resonance imaging, the number of @entity5 was 1-4 for each @entity1 . The 1-, 3-, and 5-year overall survival rates were 95, 74  %, and 67  % in the combination group and 88, 66, and 47  % in the surgery group, respectively (P   =   0.004); the corresponding recurrence-free survival rates for the two groups were 92, 69, and 61  % and 75, 58, and 44  %, respectively (P   =   0.001). In the multivariate analysis, treatment allocation was an independent prognostic factor for survival. Only 60 @entity1 in the combination group had sufficient imaging data, and 135 new lesions with @entity4831 deposition were diagnosed as @entity5 in 22 of 60 @entity1 , whereas 20 new lesions were found in 11 of 148 @entity1 in the surgery group. CONCLUSION: The combination of TACE and CT-guided percutaneous thermal ablation for @entity157 improves survival of @entity157 @entity1 compared with hepatectomy.
