HLA-DR antigen expression and lymphocyte subsets in transitional cell XXXX . An immunohistological study on frozen sections.

@entity1 @entity3647 @entity404 @entity5 @entity150 @entity1199 @entity405
Lymphocyte subpopulations (B cells, @entity404 , @entity405 ), @entity1199 ( @entity1199 ), monocytes/macrophages (Leu M5), and HLA-DR antigen expression were studied immunohistochemically on frozen sections from 38 @entity150 specimens. T cells predominated over B cells in all @entity5 . @entity404 -positive lymphocytes predominated over @entity405 in the stroma ( @entity404 / @entity405 : 1.35/l), while in @entity5 cells @entity405 was the prominent subpopulation ( @entity405 / @entity404 : 1.75/l). Aberrant HLA-DR expression was found in 21.05 per cent of @entity150 . A strong correlation between @entity404 and @entity405 population densities and macrophages with the other subpopulations was noticed. In HLA-DR-positive @entity5 , there was no correlation of the percentage of positive cells with @entity404 - and @entity405 -positive lymphocyte populations. Various parameters including @entity1199 receptors, B cells, @entity405 - and @entity404 -positive cells, and macrophages did not differ significantly between the groups of @entity5 expressing and not expressing HLA-DR antigen. There were no statistically significant differences in the population densities of B cells, @entity405 - or @entity404 -positive cells, @entity3647 , monocytes/macrophages, and HLA-DR antigen expression among various clinicopathological parameters, including growth pattern, histological grade and clinical stage or @entity1 's age and sex. These findings suggest that in transitional cell @entity150 , HLA-DR antigen expression is independent of lymphocyte subpopulations. It is therefore possible that HLA-DR expression by @entity5 cells reflect the existence of separate HLA-DR-positive or HLA-DR-negative @entity5 clones.
