Dissociation between antinociceptive and anti-inflammatory effects of @entity117 and XXXX in the @entity406 test.

@entity19 @entity117 @entity1337 @entity406 @entity2918 @entity3352 @entity1281
It is assumed that the mild @entity1337 produced by @entity117 ( @entity1281 ) and @entity3352 is due to a common mode of action, namely inhibition of the cyclo-oxygenase reaction in the synthesis of @entity2918 . It has, however, been difficult to separate the influence of the anti-inflammatory activity from pure @entity1337 in standard animal tests using a fully developed inflammatory state. In the present experiments a modification of the @entity406 test in @entity19 is used. Licking of the injected paw is recorded after the injection of a small nociceptive amount of @entity406 (20 microliters, 1%). The results show that the response to @entity406 is biphasic with an early (0-5 min) and a late (20-30 min) phase of high licking activity. @entity1281 had a dose-dependent antinociceptive effect during both the early and the late phases. In contrast, antinociceptive effect of @entity3352 was found only during the late phase. On the basis of these results it may be suggested that inhibition of the cyclo-oxygenase reaction has no major effect on the early phase in the @entity406 test. This also suggests that @entity1281 and @entity3352 are antinociceptive through partially different modes of action. In addition to an anti-inflammatory effect common to both drugs, @entity1281 may have a direct antinociceptive action.
