Endothelial cell loss and complication rates with combined Descemets stripping endothelial keratoplasty and XXXX surgery in a UK centre.

@entity1 @entity231 @entity260 @entity3816
PURPOSE: To report 6-month, 1- and 2-year endothelial cell loss (ECL), @entity260 in a large series of @entity1 undergoing either Descemets stripping endothelial keratoplasty (DSEK) or a combined phacoemulsification and DSEK in a UK centre. @entity1 AND METHODS: @entity1 undergoing DSEK with or without concurrent @entity231 surgery were included in this retrospective study. Surgeries were performed between January 2006 and May 2013. Main outcomes included @entity260 and percentage ECL. RESULTS: DSEK was performed in 226 eyes (210 @entity1 ). Of these, 141 eyes (126 @entity1 ) underwent DSEK alone and 85 eyes (84 @entity1 ) underwent DSEK combined with @entity231 surgery. Excluding complex anterior segment pathology the mean percentage ECL at 6, 12 and 24 months was 40.5  13.4, 45.1  14.6 and 53.1  13.0 in the DSEK group and 40.7  15.4, 42.6  15.3 and 49.6  16.5 in @entity1 undergoing the combined procedure, respectively. There was no significant difference in percentage ECL at 6 or 24 months between the two groups both in complex and routine cases. @entity3816 occurred in four @entity1 undergoing DSEK and three undergoing combined procedure. @entity260 rates did not reach statistical significance between the groups. CONCLUSION: Mean ECL and complication rates were comparable at 6, 12 and 24 months in routine cases undergoing concurrent DSEK with @entity231 surgery and those undergoing DSEK. These data support the combined procedure in @entity1 requiring both @entity231 surgery and endothelial keratoplasty. Further collaboration to report endothelial cell counts from other UK centres should be encouraged.
