Hemostatic variables, @entity1735 metabolism and lipid profile in XXXX with low body mass index.

@entity1 @entity2289 @entity28 @entity1674 @entity1735 @entity2915 @entity3479 @entity413 @entity165
The aim of this study was to evaluate hemostatic variables in @entity1 according to different body mass index (BMI) values, and then correlate them with some metabolic parameters - fasting insulin and @entity413 , total @entity165 , high-density lipoprotein (HDL)- @entity165 , low-density lipoprotein (LDL)- @entity165 and @entity1674 . Eighty-four female @entity1 aged 18-39 years were recruited, and agreed to participate in the study. The study group was divided into three subgroups according to BMI: low BMI (BMI < 18.5 kg/m2; n = 43), normal-weight (control) (BMI 18.5-24.99 kg/m2; n = 21) and overweight/ @entity28 (BMI > 25 kg/m2; n = 20). BMI was calculated, and the following measurements were taken: International Normalized Ratio, antithrombin III, @entity3479 ) activity, @entity3479 -antigen, plasma fibrinogen level, factor VII, Plasminogen activator inhibitor (PAI)-1 activity and antigen and metabolic parameters: fasting insulin and @entity413 , total @entity165 , HDL- @entity165 , LDL- @entity165 and @entity1674 . The results were statistically analyzed. In the low BMI group, a negative correlation between fasting insulin and @entity2289 activity, and a positive correlation between fasting @entity413 and @entity2289 antigen were observed. Also, a strong negative correlation between @entity2289 activity and insulin/ @entity413 index was found. Plasma insulin levels were significantly lower in the low-BMI @entity1 than in the overweight/ @entity28 group (p < 0.001) and with no difference compared to the control group. We did not find any difference in fasting @entity413 level between all groups. HDL- @entity165 showed the highest levels in the normal BMI group and was significantly higher than in the low BMI and @entity28 groups (p < 0.05 and p < 0.01, respectively). @entity2289 activity in the low BMI @entity1 revealed @entity2915 in comparison to control and overweight/ @entity28 @entity1 (p < 0.001 and p < 0.05, respectively). Lower antigen levels were also shown as compared to both these groups (p < 0.001 and p < 0.001, respectively). Similar results were obtained with @entity3479 antigen levels (p < 0.001 and p < 0.001, respectively). There were no differences in activity of @entity3479 in all groups. Obese @entity1 showed significantly higher fibrinogen levels than other BMI groups (p < 0.001 and p < 0.001 respectively). Analysis of hemostatic variables in @entity1 with a low BMI testify to the impaired fibrinolysis in this group, also showing a strong correlation with @entity1735 metabolism.
