Conscious sedation for EUS of the esophagus and stomach: a double-blind, randomized, controlled trial comparing XXXX with placebo.

@entity1 @entity148 @entity1363
BACKGROUND: @entity1 undergoing EUS usually receive intravenously administered sedative medication. A double-blind, prospective, randomized trial was conducted to compare @entity1363 with a placebo for EUS of the esophagus and stomach and to assess @entity1 tolerance and endoscopic feasibility. METHODS: A total of 111 @entity1 were randomized to receive @entity1363 or a placebo. @entity1 used a visual analogue scale to score pre-EUS @entity148 and tolerance for the procedure. Endoscopists used a visual analogue scale to score ease of echoendoscope introduction and overall @entity1 cooperation. Subsequent to EUS, @entity1 were asked if they were willing to undergo the procedure under the same conditions. RESULTS: The @entity1 ' visual analogue scale scores indicated that tolerance for the introduction of the echoendoscope and the procedure overall were both significantly better in the @entity1363 group. Overall @entity1 tolerance was predicted by sedation (p < 0.001) and pre-EUS @entity148 (p = 0.024). Endoscopists' visual analogue scale scores showed that ease of echoendoscope introduction was significantly better in the @entity1363 group. There was no significant difference in overall @entity1 cooperation during the procedure. There were no significant differences in introduction time, total procedure time, or @entity1 ' willingness to undergo the procedure under the same conditions. CONCLUSIONS: EUS of the esophagus and stomach without intravenous sedation is feasible for endoscopists and @entity1 . @entity1 prefer intravenous administration of @entity1363 . Assessment of @entity148 before EUS may indicate whether administration of @entity1363 can improve tolerance for the individual @entity1 .
