Postural stability under globus pallidus internus stimulation for XXXX .

@entity1 @entity14243 @entity6389 @entity2845 @entity3519
OBJECTIVE: Deep brain stimulation of the globus pallidus internus ( @entity14243 -DBS) is an efficient and safe treatment for medically refractory @entity3519 . However, recent studies reported gait problems, falls and @entity2845 in @entity1 after the DBS procedure. The aim of this study was to quantify the effect of @entity14243 -DBS on postural performance in @entity1 with @entity6389 . METHODS: Thirteen @entity1 with focal @entity3519 and @entity14243 -DBS participated in the study. We performed two postural tests (pull test and push and release test) in on- and off-stimulation conditions and recorded the movements of the @entity1 with inertial sensors. RESULTS: Under stimulation @entity1 exhibited a higher number of steps (p=0.015), reduced first step length (p=0.011) and lower stepping velocity (p=0.001), compared to off stimulation. We observed a higher number of steps in the push and release test compared to the pull test (p=0.038). The interaction between stimulation condition and test type was significant (p=0.027). CONCLUSIONS: The velocity and amplitude of postural reactions are compromised by @entity14243 -DBS in @entity1 with @entity6389 . SIGNIFICANCE: This information corresponds to @entity1 's reports of falls and postural instability after @entity14243 -DBS. Pre-operatively, @entity1 should be informed about the possibility of the occurrence of such phenomena.
