Effect of XXXX concentration on event-related potentials during painful tooth stimulation.

@entity1 @entity117 @entity26 @entity1337 @entity158 @entity3810 @entity3575
Effects of inhaling three levels of @entity3810 in @entity26 on event-related brain potentials (ERPs) and @entity158 report were examined in 10 volunteers undergoing painful electrical stimulation of tooth pulp. Previous work by the authors demonstrated that inhalation of @entity3810 33 per cent in @entity26 , iv injection of 0.1 mg @entity3575 , oral administration of 975 mg @entity117 , and electrical acupunctural stimulation all reduced ERP amplitudes obtained a vertex during painful tooth pulp stimulation. The authors report here the demonstration of a dose-response relationship between increasing concentrations of @entity3810 in @entity26 and measures of ERP amplitude and @entity158 report. Subjects inhaled room air, @entity3810 25 per cent, 37 per cent, and 50 per cent in @entity26 while ERPs were recorded and @entity158 reports were given. The procedure was repeated on three separate days with each subject experiencing all levels of treatment on each day. Analyses of variance revealed that both ERP amplitude and @entity158 report significantly decreased as dosage increased, and a significant linear trend was observed for the positive-going ERP wave-form deflection between 160 and 240 ms. @entity158 report scores decreased significantly (P less than 0.001) and proportionally as dosage increased, but there was not a significant linear trend. Inhalation of @entity3810 in @entity26 increased peak latency for the negative component at 50 ms and the positive component at 90 ms but not for later components. These outcomes demonstrate that amplitude measures of the vertex ERP obtained with dental dolorimetry correlate consistently with @entity158 and @entity1337 . Simultaneous assessment of brain electrical activity and subjective report appears to be a useful approach for the assessment of @entity1337 in @entity1 .
