The role of racial genetic admixture with XXXX outcomes: An NRG Oncology/Gynecologic Oncology Group study.

@entity1204 @entity1 @entity204
PURPOSE: Racial genetic admixture (RGA), a measure to account for ancestral genetic background that correlates with individual's racial classification, could provide insights on causation of racial disparity in @entity1204 ( @entity1204 ). Our objective is to evaluate the association of RGA with @entity1204 outcomes. METHODS: @entity1204 @entity1 enrolled onto the GOG-210 protocol were eligible. A randomized subcohort stratified by stage and self-reported race/ethnicity of black or white was used. Genotyping was performed using custom-selected Ancestry Informative Markers to calculate individual admixture estimates of African and European ancestral background. RESULTS: A total of 149 @entity1 were evaluated (self-reported race: 70 black _ 79 white). Mean RGA for African ancestry for self-reported black @entity1 was 0.65 (range 0.04-0.86); while mean RGA for European ancestry for self-reported white @entity1 was 0.77 (range 0.12-0.88). Progression-free survival (PFS) analysis using proportional hazards models stratified by stage and race revealed that each 0.10 increase in African ancestry was associated with worse PFS with hazard ratio (HR) of 1.11 (95% CI 0.90-1.37). Each 0.10 increase in European RGA was associated with improved PFS with HR of 0.86 (95% CI 0.69-1.07). Using tertiles of African RGA showed increasing risk of progression of @entity204 with increasing African RGA (with 0-5% as reference), HR (95% CIs) for top two tertiles are: 6%-66%: 1.38 (0.64, 2.97), and 67%-86%: 2.27 (0.74, 6.95). CONCLUSION: RGA demonstrated a trend with PFS in self-reported black and white @entity1 with @entity1204 . @entity1 with increased levels of African ancestry showed a trend towards worse survival after stratifying by stage/race.
