High early XXXX rate in @entity378 @entity1 in Malawi.

@entity1 @entity378 @entity204 @entity1907
SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In @entity1 registered with all types of @entity378 ( @entity378 ) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti- @entity378 treatment @entity378 @entity204 occurred. DESIGN: A retrospective study using information from @entity378 registers, health centre registers, @entity378 treatment cards and @entity378 ward admission books. RESULTS: A total of 16,004 @entity1 were registered with all types of @entity378 , 6471 with smear-positive @entity1907 ( @entity1907 ), 5305 with smear-negative @entity1907 and 4228 with @entity1907 ( @entity1907 ). Of @entity1 with all types of @entity378 , 3720 (23%) died: @entity204 rates were 22% in smear-positive @entity1907 , 26% in smear-negative @entity1907 and 22% in @entity1907 . Month of @entity204 was known in 3371 @entity1 (91% of those who died) and day of @entity204 in 3326 @entity1 (89% of those who died). In @entity1 who died, 19% of @entity204 occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early @entity204 occurred in @entity1 with smear-negative @entity1907 and @entity1907 and in relation to increasing age. CONCLUSIONS: There was a high overall @entity204 rate in @entity378 @entity1 registered in 1997, with 40% of @entity204 occurring in the first month of treatment. Strategies to combat this problem are needed.
