Anti-metastatic therapy by @entity71951 in combination with an anti- XXXX agent.

@entity1 @entity19 @entity5 @entity2 @entity2879 @entity71951 @entity358 @entity3
We have demonstrated that @entity71951 (UTI) purified from @entity1 urine is able to inhibit lung @entity3 of @entity19 @entity2 (3LL) cells in experimental and spontaneous @entity3 models. In this study, we have investigated whether UTI in combination with an anti- @entity5 drug, @entity2879 , can prevent @entity5 @entity3 and show an enhanced therapeutic effect. Subcutaneous (s.c.) implantation of 3LL cells (1 x 10(6) cells) in the abdominal wall of C57BL/6 female @entity19 resulted in macroscopic lung @entity3 within 21 days. Microscopic lung @entity3 was established by day 14 after @entity5 cell inoculation, and surgical treatment alone after this time resulted in no inhibition of lung @entity3 . The number of @entity5 colonies in the group of @entity19 which received surgery at day 21 was greater than in @entity19 which had @entity5 left in situ (P = 0.0017). Surgical treatment on day 7, followed by UTI administration (s.c.) for 7 days, led to a @entity358 compared with untreated animals. A significant inhibition of the formation of pulmonary @entity3 was obtained with daily s.c. injections of UTI for 7 days immediately after @entity5 cell inoculation. UTI administration did not affect the primary @entity5 size at the time of operation. In addition, @entity2879 treatment alone led to a smaller primary @entity5 and yielded reduction of the formation of lung @entity3 in the group of @entity19 which received surgery at day 14 (P = 0.0026). Even in @entity19 which received surgical treatment on day 14, followed by the combination of UTI (500 micrograms per @entity19 , days 14, 15, 16, 17, 18, 19 and 20) with @entity2879 (40 mg kg-1, days 14, 18 and 22), there was significant reduction of the formation of lung @entity3 (P = 0.0001). Thus, the combination of an anti-metastatic agent with an anti- @entity5 drug, @entity2879 , might provide a therapeutically promising basis for anti-metastatic therapy.
