Expression analysis of XXXX isoforms S and V3, in @entity1 with @entity1721 .

@entity1 @entity5 @entity1721 @entity1759 @entity3
OBJECTIVES: @entity1759 is a member of the cell adhesion molecules family. Naturally, CD44S, along with CD44V3 influence the cell motility, migration, and adhesion, while in @entity5 cells they lead to @entity5 invasion, progression, and @entity3 . The purpose of this research is to evaluate the CD44S and CD44V3 expression in @entity1721 ( @entity1721 ) and to reveal their correlations with clinicopathological features of @entity1 . MATERIALS AND METHODS: Fresh tumoral and distant @entity5 -free esophageal tissues were obtained from 50 @entity1 with @entity1721 . Using quantitative real-time PCR, the expression levels of CD44S and CD44V3 were quantified and compared in both groups of cells. The @entity1 had not received any therapeutic interference, such as chemotherapy or radiation, prior to sampling. RESULTS: Significant overexpression of CD44S and CD44V3 mRNA was observed in 13 (26.0%, P=0.03) and 11 (22.0%, P=0.007) @entity5 specimens, respectively. The expression of the genes were significantly correlated not only with each other (P=0.0001), but also with differentiation grade of @entity5 (P=0.033), stage of @entity5 progression (P=0.003), and depth of @entity5 invasion (P=0.00). In addition, low level of CD44V3 mRNA expression was attended to be associated with @entity5 invasion. CONCLUSION: There is no correlation between @entity1759 S expression with clinicopathological features of @entity1 ; however, simultaneous expression of these genes has an important effect on tumorigenesis.
