Effects of subchronic inhalation exposure of XXXX to a high-boiling coal liquid.

@entity39 @entity19 @entity11728 @entity2659 @entity35
@entity19 ( @entity2659 ) were exposed to aerosol concentrations of 0.0, 0.03, 0.14, or 0.69 mg/liter of @entity11728 ( @entity11728 ), a high-boiling coal liquid from the solvent-refined coal (SRC)-II process. Exposures were for 6 hr/day, 5 days/week for 13 weeks. Particle sizes ranged between 1.6 and 1.8 micron, mass median aerodynamic diameter, with a geometric standard deviation range of 1.9-2.5. Growth for high-dose males was significantly less than that of the control group. Compared to controls, weights of liver were significantly higher and those of ovaries and thymus significantly lower; these changes were significant on both absolute and relative weight bases. The number of red blood cells, volume of packed red cells, and hemoglobin concentration for animals from the high-dose group were significantly lower than those of controls. Microscopic examination of organ sections showed focal hepatic @entity39 and nonspecific hepatopathy. Additionally, olfactory epithelial degeneration occurred in a dose-dependent manner. Results from this study indicated that exposure to @entity11728 caused adverse effects at the high dose and that these changes were either less severe or absent in middle-dose group @entity19 . Comparison of these results with those for @entity35 indicated that with @entity35 the biological effects were more severe and present at lower doses than was observed for @entity19 .
