Clinical implications of @entity854 of bone marrow myeloid cell compartment in XXXX .

@entity1 @entity10793 @entity13352 @entity5750 @entity3058 @entity2590 @entity5824 @entity854 @entity1116 @entity3053 @entity1442 @entity9536 @entity2280 @entity1349
PURPOSE: to evaluate the biological and clinical implications of @entity854 of bone marrow myeloid cell compartment in @entity1 with primary @entity2590 ( @entity2590 ). METHODS: analysis of @entity3058 profiles was performed by flow cytometric immunophenotyping on bone marrow mononuclear cell (BMMNCs) specimens from 39 adult @entity2590 @entity1 and 5 healthy individuals. Expression of @entity3058 profiles was correlated with @entity13352 subtype, cytogenetics, CFU-GM colony growth, @entity1349 ( @entity1349 ) and leukemic transformation (LT). RESULTS: expression levels of early differentiation and myelo-monocytic antigens ( @entity3053 , @entity10793 , @entity1116 , @entity5750 and @entity5824 ) on myeloid cell compartment of BMMCs were significantly higher in @entity2590 @entity1 in comparison to healthy control group, suggesting maturational left shift of bone marrow myeloid cell compartment in @entity2590 . @entity2280 antigen expression was in a positive linear correlation with HLA-DR antigen expression (r=0.652; p=0.0004), and in negative correlation with the expression of @entity9536 and @entity5824 antigens (r=-0.48; p=0.014 and r=-0.564; p=0.0033, respectively). Myeloid antigen ratio (HLA-DR/ @entity9536 ) was 2.5 fold higher in @entity1 with @entity2590 in comparison to control group. @entity1 with @entity1442 had significantly higher myeloid antigen ratio than @entity1 with low risk @entity2590 (p<0.05). The type of CFU-GM colony growth and the presence of chromosomal aberrations were unrelated to the proportion of @entity2280 (+) cells and elevated myeloid ratio. @entity1 with elevated proportion of @entity2280 (+) BMMNCs or elevated myeloid ratio had significantly shorter @entity1349 and higher LT rate in comparison to @entity1 whose proportion of @entity2280 (+) BMMNCs and myeloid ratio were within normal range. CONCLUSION: the presence of abnormalities in antigen expression profiles of bone marrow myeloid cell compartment has clinical implication in @entity2590 , with particular contribution in predicting the @entity1 outcome. Elevated proportion of @entity2280 (+) BMMNCs and elevated myeloid ratio of bone marrow myeloid compartment are useful immunophenotypic tools for estimation of prognosis in this very heterogeneous disorder group.
