Low-dose-rate definitive brachytherapy for high-grade XXXX .

@entity1 @entity137 @entity5 @entity3354 @entity3146 @entity5436
BACKGROUND: Treatment of high-grade @entity5436 ( @entity3354 ) is controversial and could include surgical excision, topical medication, brachytherapy, or other treatments. We report the results of low-dose-rate (LDR) vaginal brachytherapy for grade 3 @entity3354 ( @entity3354 ) over a 25-year period at Gustave Roussy Institute. @entity1 AND METHODS: We retrospectively reviewed the files of all @entity1 treated at Gustave Roussy Institute for @entity3354 since 1985. The treatment consisted of LDR brachytherapy using a personalized vaginal mold and delivered 60 Gy to 5 mm below the vaginal mucosa. All @entity1 had at least an annual gynecological examination, including a vaginal smear. RESULTS: Twenty-eight @entity1 were eligible. The median follow-up was 41 months. Seven @entity1 had a follow-up <2 years, and the median follow-up for the remaining 21 @entity1 was 79 months. The median age at brachytherapy was 63 years (range, 38-80 years). Twenty-six @entity1 had a history of @entity3354 recurring after @entity3146 and 24 had a previous hysterectomy. The median brachytherapy duration was 4.5 days. Median doses to the International Commission of Radiation Units and Measurements rectum and bladder points were 68 Gy and 45 Gy, respectively. The median prescription volume (60 Gy) was 74 cm(3). Only one "in field" recurrence occurred, corresponding to a 5- and 10-year local control rate of 93% (95% confidence interval, 70%-99%). The treatment was well tolerated, with no grade 3 or 4 late @entity137 and only one grade 2 digestive @entity137 . No second @entity5 were reported. CONCLUSION: LDR brachytherapy is an effective and safe treatment for @entity5436 .
