A pro-inflammatory glycoprotein biomarker is associated with lower @entity648 in XXXX .

@entity209 @entity648 @entity6 @entity1851
OBJECTIVES: @entity648 exerts anti-oxidative and anti-inflammatory properties which may beneficially influence the development of @entity209 . A nuclear magnetic resonance (NMR) spectroscopy-based glycoprotein biomarker, designated GlycA, whose signal originates from several glycosylated acute-phase proteins, has been recently developed. We tested whether plasma GlycA is associated with @entity648 in subjects with and without @entity6 . DESIGN AND METHODS: GlycA (NMR spectroscopy), high sensitivity @entity1851 (hs-CRP) and @entity648 were measured in 58 fasting subjects with @entity6 and in 63 subjects without @entity6 (including 65 subjects with @entity6 ). RESULTS: GlycA and hs-CRP were higher, coinciding with lower @entity648 in @entity6 (p<0.01 for each). In all subjects combined, GlycA was strongly correlated with hs-CRP (r=0.631, p<0.001). Age-, sex- and @entity6 status-adjusted multivariable linear regression analysis demonstrated that GlycA and hs-CRP were both associated positively with the presence of @entity6 (b=0.256, p=0.014 and b=0.259, p=0.012, respectively). GlycA and hs-CRP were negatively related to @entity648 (b=-0.258, p=0.007 and b=-0.305, p<0.001, respectively), independent of @entity6 (p>0.05 for each) and @entity6 status (p>0.50 for each). CONCLUSIONS: GlycA is elevated in @entity6 , and may represent a quantitative measure of a pro-inflammatory state. Increased levels of glycosylated acute-phase proteins are associated with lower @entity648 in @entity6 .
