Clinical implications of abnormalities of chromosomes 1 and 13 in XXXX .

@entity1 @entity2008 @entity1582
Stratification of @entity1 with @entity1582 according to clinical severity was attempted by chromosomal analysis of 180 bone marrow specimens from 79 @entity1 . The 79 @entity1 were hospitalized and treated between 1994 and 1999. Abnormalities of chromosome 1 were detected at the initial medical examination in 8 (10%) of the 79 @entity1 and were found during follow-up in additional 3 @entity1 . Abnormalities of chromosome 1 were often detected in IgA (4/17) and IgD (2/4) @entity1582 , while detection in IgG @entity1582 was relatively rare (4/42). The relevant break points were 1q12 in 5 @entity1 and 1q42 and 1q21 in 3 @entity1 , while 3 @entity1 had trisomy 1. Deficiency of the long arm of chromosome 13 was detected in 6 @entity1 , and this was believed to imply a prognosis. The long arm was completely deleted in 2 @entity1 and part of the arm (13q10-14) was deleted in 4 @entity1 . It is interesting that all 6 @entity1 had concomitant abnormalities of chromosome 1. Although the initial response to treatment of @entity1 having abnormal chromosomes 1 and 13 was comparable to that of @entity1 having other @entity2008 or @entity1 who were karyotypically normal, the median survival time was only 18 months (p < 0.02). Consequently, aggressive treatment such as early stem cell transplantation and so on is needed to improve their survival.
