Rapid fecal calprotectin testing to assess for @entity66 activity in XXXX : A diagnostic cohort study.

@entity1 @entity66 @entity2286 @entity344 @entity29 @entity14 @entity1851
BACKGROUND AND AIM: With increasing numbers of @entity1 diagnosed with @entity29 ( @entity29 ), it is important to identify noninvasive methods of detecting disease activity. The aim of this study is to examine the diagnostic accuracy of fecal rapid calprotectin (FC) testing in the detection of endoscopically active @entity29 . @entity1 AND METHODS: All consecutive @entity1 presenting to outpatient clinics with @entity344 were prospectively recruited. @entity1 provided FC samples. Sensitivity (Sn), specificity (Sp), positive predictive value ( @entity2286 ), and negative predictive value (NPV) for FC were calculated. Receiver-operator characteristics (ROC) curve was used to identify the ideal FC cutoff that predicts @entity66 activity. Correlation between FC and @entity66 activity, disease location, and @entity1851 ( @entity1851 ) levels were measured. RESULTS: One hundred and twenty-six @entity1 , of whom 52% were females, were included in the final analysis with a mean age of 44.4    16.7 years. Comparing FC to endoscopic findings, the following results were calculated: A cutoff point of 100  g/g showed Sn = 83%, Sp = 67%, @entity2286 = 65%, and NPV = 85%; and 200  g/g showed Sn = 66%, Sp = 82%, @entity2286 = 73%, and NPV = 77%. Based on ROC curve, the best FC cutoff point to predict @entity66 activity was 140  g/g. Using this reference, FC levels strongly correlated with @entity14 and predicted endoscopic activity. CONCLUSIONS: FC is an accurate test when used as an initial screening tool for @entity1 suspected of having active @entity29 . Given its noninvasive nature, it may prove to reduce the need for colonoscopy and be an added tool in the management of @entity29 .
