@entity71975 : increased mucosal mast cells in chronic intractable XXXX .

@entity1 @entity11162 @entity5310 @entity294 @entity1711 @entity29 @entity1710 @entity71975 @entity4143
CONTEXT: In some adult @entity1 with chronic intractable @entity294 , the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine @entity1710 - @entity1711 staining. OBJECTIVES: To assess the concentration of mast cells in colonic or duodenal biopsy specimens by immunohistochemical analysis for mast cell tryptase from @entity1 with chronic intractable @entity294 and to evaluate their response to drugs affecting mast cell function. DESIGN: Mast cells per high-power field were assessed in biopsy specimens from 47 @entity1 with chronic intractable @entity294 , from 50 control subjects, and from 63 @entity1 with other specific diseases that cause chronic @entity294 ( @entity29 , @entity4143 , and @entity11162 ). @entity1 with chronic intractable @entity294 who had more than 20 mast cells per high-power field were administered drugs affecting mast cell mediator function and release. RESULTS: The mean +/- SD concentration of mast cells in the 50 control subjects was 13.3 +/- 3.5 cells per high-power field; hence, @entity1 with more than 20 mast cells per high-power field were considered to have increased mast cells. Thirty-three (70%) of 47 @entity1 with chronic intractable @entity294 had increased mast cells, and symptoms were controlled by drug therapy in 22 (67%) of the 33 @entity1 . No @entity1 had systemic or cutaneous @entity5310 . No increase in mast cells was seen in @entity1 with other common causes of chronic @entity294 . CONCLUSIONS: In chronic intractable @entity294 , colonic or duodenal biopsy specimens may appear unremarkable on routine @entity1710 - @entity1711 staining, but increased mast cells may be demonstrated by immunohistochemistry for mast cell tryptase, with the novel term @entity71975 describing this condition. Similar increases in mast cells are not apparent in control populations or in @entity1 with other specific diseases that cause chronic @entity294 . The cause of the increased mast cells remains to be elucidated.
