In silico analysis and prioritization of drug targets in XXXX .

@entity1 @entity1036 @entity10437 @entity9138 @entity1939 @entity364 @entity59009 @entity22214
UNASSIGNED: @entity1036 has emerged as a major ophthalmic problem and a leading cause of @entity1939 , since its recognition in 1879. Filamentous fungi are major causative of @entity1036 . In India, the main etiological organism responsible for @entity1036 is Aspergillus species followed by Fusarium species. In South India, Fusarium based keratitis scales up to 43%. Nearly one-third of @entity1036 treatment results in failure, as @entity364 are highly resistant to antibiotic therapies. Therefore, there is need to determine novel and specific targets to constrain @entity22214 in @entity1 eye. In this study, we implemented subtractive proteomics coupled with in silico functional annotation to prioritize potential and specific drug targets which can be used to modulate the virulence of @entity10437 .pisi ( @entity59009 MPVI). The results infer that @entity9138 thiazole synthase (Thi4), an intracellular membrane bound protein as the potential target, which is a core protein in biological and metabolic process of this pathogen. Moreover, this protein occurs in the @entity9138 thiazole biosynthesis pathway which is unique to @entity10437 and devoid in @entity1 . Hence, we predicted a plausible structure for this protein and also performed ligand-binding cavity analysis which can be for a strong base for drug designing studies. This study will pave way in better understanding of potential drug targets in @entity10437 and also leading to therapeutic interventions of @entity364 .
