Pro-atherogenic postprandial profile: meal-induced changes of lipoprotein sub-fractions and inflammation markers in @entity28 XXXX .

@entity1 @entity650 @entity28 @entity1735 @entity1386 @entity413 @entity165
BACKGROUND AND AIMS: Obesity is a pro-atherogenic condition and postprandial lipoprotein profile and circulating cytokines changes may contribute to promote the process. The aim of this study is to investigate postprandial metabolic response, lipoprotein oxidation and circulating cytokine levels, after the ingestion of two different meals with different fat/ @entity1735 ratio. METHODS AND RESULTS: Ten prepubertal @entity28 @entity1 consumed two meals with the same energy and protein content but with a different @entity1735 to fat ratio: 1) @entity1386 ( @entity1386 ): 61% @entity1735 , 27% fat; 2) high fat (HF): 37% @entity1735 , 52% fat. The AUC of @entity413 and insulin were significantly (p < 0.05) lower after the HF meal. HF meal was followed by a significant decrease in the @entity165 carried in the HDL fractions, while @entity165 in the small, dense LDL and in the VLDL particles increased, as compared to baseline (p < 0.05 for all). No differences were found in the @entity165 distribution after the @entity1386 meal. Moreover, HDL-C concentration was lower (p < 0.05) at 300 min after HF vs. @entity1386 meal. Oxidized LDL (ox-LDL) concentration increased after the HF meal but not after the @entity1386 meal [9.3(2.2) vs 1.8(2.2)% from baseline, P < 0.02)]. A positive association (r > 0.3, P < 0.05) was observed between the densest LDL particles and the ox-LDL plasma levels. A reduction of @entity650 was found at 120 min after the @entity1386 [-23.3(5.5) vs -8.4(3.8)% from baseline, P < 0.05)] compared with the HF meal. CONCLUSION: A simple change of    25% of energy load from fat to @entity1735 in a meal significantly improves postprandial pro-atherogenic factors in @entity28 @entity1 .
