Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced @entity647 in XXXX via NF- k B Signaling.

@entity32 @entity558 @entity19988 @entity3096 @entity19 @entity7651 @entity5533 @entity42095 @entity358 @entity27736 @entity224 @entity647
The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- ( @entity558 -) induced @entity647 in @entity19 . The effects of Scutellariae Radix heat-processed at 160  C ( @entity27736 ) were compared with those of nonheat-processed Scutellariae Radix (NSR). The @entity558 -treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or @entity27736 improved both the body and lung weights. The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with @entity27736 . The reduced @entity224 dismutase and @entity5533 increased significantly by both NSR and @entity27736 . Also, the dysregulated oxidative stress and @entity32 were significantly ameliorated by NSR and @entity27736 . The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Ba degradation. Also, lung histological change was markedly suppressed by @entity27736 rather than NSR. Overall, the ameliorative effects of @entity27736 were superior to those when being nonheat-processed. The representative @entity3096 contents of Scutellariae Radix that include @entity7651 , @entity19988 , and @entity42095 were greater by heat process. These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of @entity358 caused by @entity558 .
