Molecular analysis of sequence variants in the Fcepsilon receptor I beta gene and XXXX gene promoter in Italian atopic families.

@entity1 @entity70988 @entity37938 @entity566 @entity402 @entity3646 @entity47188 @entity8997 @entity12950
BACKGROUND: The genetic variants in the Fcepsilon receptor I beta gene ( @entity37938 ) and the T allele of the ( @entity70988 ) polymorphism of @entity3646 gene promoter were reported to be associated with @entity402 . But the data of the studies in different populations are contrasting with one another. METHODS: A group of 25 Italian nuclear families were studied. In each family at least two allergic subjects were present. The allergic @entity1 were 65 and the allergic relatives were 35. One hundred and three nonallergic unrelated controls included outpatiens with no history of @entity402 . The ( @entity70988 ) promoter polymorphism of the @entity3646 and the genetic variant @entity37938 of @entity12950 genes were analysed by the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: A significant difference was observed in the genotype frequency at codon 237 of the @entity12950 gene between allergic @entity1 and nonatopic control (P < 0.01) and in the allergic relatives (P < 0.001). In the @entity1 , the @entity37938 polymorphism was also associated with elevated circulating levels of immunoglobulin E. The @entity8997 allele of @entity3646 promoter gene showed no association with @entity402 . CONCLUSIONS: In our study, the @entity37938 polymorphism of the @entity12950 gene was associated with @entity402 . Our results have not pointed out an association between the ( @entity70988 ) promoter polymorphism of the @entity3646 gene and @entity402 . These data suggest the potential role of the @entity47188 gene in the development of the @entity566 .
