Molecular biology of XXXX .

@entity1 @entity8 @entity11089 @entity5 @entity4771 @entity12233 @entity79 @entity1391 @entity74
@entity1391 plays a central role in many of the basic processes essential to the cell and organism. In particular, skeletal mineralisation is dependent on the appropriate regulation of @entity1391 in the body, and any disturbances in @entity1391 homeostasis can have severe repercussions on the integrity of bone. The kidney regulates the serum levels of @entity1391 by tubular mechanisms which are not fully understood. Furthermore, the processes involved in regulating renal tubular @entity1391 reabsorption are complex, and involve a large number of factors. It is not surprising therefore that defects in renal @entity1391 handling result in a failure of bone mineralisation. There are three well characterised conditions which are associated with @entity8 resulting in a @entity1391 leak, with consequent @entity79 . Two are familial, @entity11089 ( @entity11089 ), and @entity12233 ( @entity12233 ). The third is acquired via a @entity5 , @entity4771 ( @entity4771 ), and may well have relevance to the @entity74 . Recent advances in molecular genetics are permitting the identification of genes involved in @entity1 diseases from their chromosomal location. These approaches are now being applied to the analysis of the hypophosphataemias. The isolation of the genes responsible for the @entity8 will be an important achievement. Ultimately this will help to increase our understanding of the mechanisms involved in the control of @entity1391 handling in the body.
