Synergistic effect between intrathecal non- @entity143 antagonist and @entity2682 on @entity1931 induced by spinal nerve ligation in XXXX .

@entity2227 @entity1024 @entity1931 @entity2682 @entity1109 @entity1023 @entity143 @entity35 @entity9
BACKGROUND: @entity2227 and non- @entity1024 ( @entity143 ) receptors have been implicated in the development of neuroplasticity in the spinal cord in @entity9 . The spinal cord has been identified as one of the sites of the analgesic action of @entity2682 . In the current study, the authors determined the antiallodynic effect of intrathecal @entity1023 ( @entity1023 ) in a @entity35 model of @entity9 . Also tested was a hypothesis that intrathecal injection of @entity1023 and @entity2682 produces a synergistic effect on @entity1931 in @entity1109 @entity35 . METHODS: Allodynia was produced in @entity35 by ligation of the left L5 and L6 spinal nerves. Allodynia was determined by application of von Frey filaments to the left hind paw. Through an implanted intrathecal catheter, 10-100 microg @entity2682 or 0.5-8 microg @entity1023 disodium (a water-soluble formulation of @entity1023 ) was injected in conscious @entity35 . Isobolographic analysis was performed comparing the interaction of intrathecal @entity2682 and @entity1023 using the ED50 dose ratio of 15:1. RESULTS: Intrathecal treatment with @entity2682 or @entity1023 produced a dose-dependent increase in the withdrawal threshold to mechanical stimulation. The ED50 for @entity2682 and @entity1023 was 45.9+/-4.65 and 3.4+/-0.22 microg, respectively. Intrathecal injection of a combination of @entity1023 and @entity2682 produced a strong synergistic antiallodynic effect in @entity1109 @entity35 . CONCLUSIONS: This study shows that intrathecal administration of @entity1023 exhibits an antiallodynic effect in this @entity35 model of @entity9 . Furthermore, @entity1023 and @entity2682 , when combined intrathecally, produce a potent synergistic antiallodynic effect on @entity9 in spinal nerve-ligated @entity35 .
