Beyond the hippocampus: MRI volumetry confirms widespread limbic @entity194 in XXXX .

@entity1 @entity194 @entity195
OBJECTIVE: To examine volumetric changes in limbic structures in @entity1 with probable @entity195 using planimetric measures on MRI. METHOD: Limbic structures (i.e., hippocampus, amygdala, anterior thalamus, hypothalamus, mamillary bodies, basal forebrain, septal area, fornix, and cingulate, orbitofrontal, and parahippocampal cortices) were traced on 3D T1-weighted MR images of 40 @entity1 with mild to moderate @entity195 and 40 age-, sex-, and education-matched normal control subjects. Limbic volumes were compared between groups and the predictive ability was assessed. RESULTS: Overall, limbic structures showed significant @entity194 in @entity195 @entity1 compared with normal control subjects. Differences (p < 0.05) were found in all limbic regions except the anterior cingulate cortex. The greatest percentage volumetric losses occurred in the septal area (34%), hippocampus (28%), amygdala (21%), parahippocampal cortex (21%), and posterior cingulate cortex (20%). Combining volumetric measures of amygdala and septal area distinguished @entity1 with @entity195 from normal control subjects with 93% accuracy. CONCLUSIONS: These results verify that system-wide limbic degeneration occurs in @entity1 with @entity195 . In addition, @entity194 in selected limbic structures was used to distinguish @entity1 with @entity195 from normal elderly individuals with over 90% accuracy in this select clinical sample. The measures require further exploration in samples more representative of those seen by primary care physicians before their utility can be accurately assessed.
