The associated regulators and signal pathway in XXXX / @entity404 mediated growth regulation in Jurkat cells.

@entity1619 @entity404 @entity517 @entity5353 @entity17090 @entity12 @entity66314 @entity6164 @entity12363
@entity17090 is a ligand and chemotactic factor for @entity404 + T cells. @entity17090 inhibits the CD3 mediated lymphocyte activation and proliferation. The effects of @entity17090 on the target cells are dependent on the cell type, the presence of co-activators etc. To understand the regulation function and mechanism of @entity17090 on target cells, we used a 130 a.a. recombinant @entity17090 to study its effects on the growth of @entity1619 cells in vitro. We found that the @entity66314 stimulated the proliferation of Jurkat cells at low dose (10(-9)M), but inhibited the growth of the cells at higher concentration (10(-5)M). Results showed that 10(-5) M of @entity66314 treatment induced an enhanced apoptosis in Jurkat cells. The treatment blocked the expression of @entity12 , but up-regulated the @entity517 and @entity5353 expression in the cells. Pre-treatment of @entity6164 inhibitor or @entity12363 inhibitor markedly increased or decreased the @entity66314 induced growth-inhibiting effects on Jurkat cells, respectively. The results suggested that the @entity66314 might be a regulator for the growth or apoptosis of Jurkat cells at a dose-dependent manner. The growth-inhibiting effects of @entity66314 might be Fas/ @entity12 independent, but, associated with the activation of @entity6164 , up-regulated expression of @entity517 and @entity5353 , and the participation of the ERK signal pathway in Jurkat cells.
