Effects of low-dose liquorice alone or in combination with XXXX on the plasma @entity972 in healthy volunteers.

@entity1369 @entity918 @entity916 @entity1372 @entity7206 @entity2740 @entity972 @entity1011
Both liquorice and @entity2740 diuretics have hypokalaemic effects. In spite of their prevalent use, there are no studies on hypokalaemia caused by the combination of liquorice and @entity7206 . We recruited 10 healthy volunteers in order to study the effects of 32 g liquorice alone or in combination with 25mg @entity918 a day for 2 weeks. The trial had a randomized, open and crossover design. During the liquorice phase, there were no changes in plasma @entity972 , @entity1372 , @entity1011 , @entity916 activity, serum @entity1369 , blood pressure or heart rate. Weight tended to increase by 0.4 kg (70.2 to 70.6 kg; p=0.056). During the liquorice- @entity918 phase, the plasma @entity972 decreased by 0.32 mmol/l (p=0.0015), plasma @entity916 activity increased by 1.6 microg/l/h (p=0.0064) and the weight decreased by 0.9 kg (70.5 to 69.6 kg, p=0.0065). Twenty per cent of the subjects (2/10) became hypokalaemic during the combined liquorice- @entity918 treatment. Furthermore, both subjects developed hypokalaemia within the first week of the combined treatment leading to premature discontinuation. The evaluation of liquorice consumption habits is warranted when initiating @entity2740 medications to avoid the excessive risk of hypokalaemia associated with the combined use of low-dose liquorice and @entity2740 diuretics.
