Associations between the codon 72 polymorphism of the XXXX gene and the risk of recurrent implantation failure.

@entity177 @entity5 @entity876
AIM: @entity177 ( @entity177 ) is the most common cause of unsuccessful pregnancy after assisted reproductive techniques. The @entity5 protein @entity876 ( @entity876 ) codon 72 polymorphism (G-C transversion) has been explored in susceptibility to @entity177 , but inconclusive results have been reported. The aim of this article is to estimate the associations between the @entity876 codon 72 polymorphism and the risk of @entity177 . MATERIALS AND METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for CC + GC versus GG, CC versus GC + GG, CC versus GG, GC versus GG genotypes, and C versus G allele, were estimated. Publication bias was explored. Statistical analyses were performed using RevMan 5.2 and Stata 11.0 software. RESULTS: A total of five case-control studies in five articles with 417 @entity177 cases and 325 controls were included. An overall random effect OR of 1.20 (95% CI, 0.66-2.19; P = 0.55) in the dominant model (CC + GC vs GG) was found. The results suggested that a lack of increased or decreased risks were found in individuals who carried the CC homozygote and heterozygote GC, in comparison with the homozygote GG. However, in subgroup analysis by ethnicity, a significantly increased risk was observed among Latin Americans in the dominant model (OR, 1.56; 95% CI, 1.04-2.33; P = 0.03). CONCLUSIONS: This meta-analysis shows that the @entity876 codon 72 polymorphism is not associated with @entity177 risk in the overall population; however, associations were found in the Latin American population.
