Lymphovascular space invasion and positive pelvic lymph nodes are independent risk factors for para-aortic nodal @entity3 in endometrioid XXXX .

@entity1204 @entity1 @entity1600 @entity3 @entity2333
OBJECTIVE: @entity1600 in endometrioid @entity1204 is uncommon, and systematic para-aortic lymph node dissection increases morbidity. The purpose of this study was to identify a subgroup of endometrioid @entity1204 @entity1 who did not require para-aortic lymphadenectomy. STUDY DESIGN: All @entity1 who had undergone surgery for endometrioid @entity1204 between 1 January 1995 and 31 December 2012 were retrospectively reviewed. @entity1 with higher risk factors for nodal @entity3 and inadequate lymphadenectomy were excluded. @entity1600 was defined as nodal @entity3 when pelvic and para-aortic lymph node dissection was performed, when para-aortic lymph node recurrence occurred after negative para-aortic lymph node dissection or when para-aortic lymph node dissection was not performed. Multivariate logistic regression models were used to identify the pathological features as predictors for @entity2333 . RESULTS: A total of 827 @entity1 were assessed, 516 (62.4%) of whom underwent pelvic and para-aortic lymph node dissection. Sixty-seven (13%) @entity1 (37 with only pelvic, 26 with pelvic and para-aortic, and 4 with only para-aortic @entity3 ) had positive lymph nodes in the pelvic and para-aortic lymph node dissection group. Multivariate analysis confirmed positive pelvic nodes (odds ratio 20.58; p<0.001) and lymphovascular space invasion (odds ratio 8.10; p=0.022) as independent predictors of @entity2333 . When these two factors were absent (in 83% of @entity1 ), the predicted probability of para-aortic lymph node @entity3 was 0.1%. CONCLUSION: Positive pelvic nodes and lymphovascular space invasion are highly associated with para-aortic lymph node @entity3 . These markers may be useful for identifying those @entity1 who require para-aortic lymph node dissection.
