Clinical Outcomes of @entity1737 with XXXX and @entity8792 Undergoing Extended Transsternal Thymectomy: A Single-Center Experience.

@entity1 @entity704 @entity1353 @entity4836 @entity1737 @entity425 @entity8792 @entity1282 @entity892 @entity1736 @entity617 @entity4653
BACKGROUND: Despite the widespread use of thymectomy in @entity1737 ( @entity1737 ) @entity1 , it has remained controversial as to whether this procedure is of a similar efficacy and clinical outcome among @entity1737 @entity1 with @entity704 and @entity8792 . AIM: We sought to determine the long-term clinical outcomes of @entity1737 @entity1 who received extended transsternal thymectomy associated with @entity4836 and @entity617 postoperatively. MATERIALS AND METHODS: In a retrospective study from January 1999 to December 2013, @entity1737 @entity1 who underwent thymectomy were followed up. Out of 41 @entity1737 @entity1 admitted in our center, 25 @entity1 had undergone thymectomy adjunctive to @entity4836 and @entity617 therapy postoperatively. The primary endpoints included improvement in individual @entity892 , @entity1736 , @entity1282 , @entity4653 , @entity1353 , and @entity425 . In addition, according to the @entity1737 Foundation of America (MGFA) criteria, response to therapy was defined as complete stable remission (CSR), pharmacologic remission (PR), and minimal manifestation (MM) as secondary endpoints. RESULTS: Majority of the @entity1 were male (60%) and the mean age of the @entity1 was 32.2    13.9 years. Fifteen (60%) and 10 @entity1 (40%) had @entity704 and @entity8792 , respectively. All the @entity1 were followed up during a mean period of of 86.9    50.3 months (minimum 10 months and maximum 168 months). The rates of CSR, PR, and MM were comparable between the @entity704 and @entity8792 groups (P = 0.584). Based on the Kaplan Meier analysis, the probabilities of CSR, PR, and MM were not significantly different between @entity1 with @entity704 and @entity8792 . CONCLUSION: The extended transsternal thymectomy, along with the postoperative regimen of @entity4836 and @entity617 was associated with a high rate of clinical improvement among @entity1737 @entity1 with @entity704 or @entity8792 .
