Up-regulation of @entity556 activity induced by @entity7 in XXXX airways.

@entity1 @entity748 @entity82 @entity556 @entity7 @entity565 @entity540
BACKGROUND: High expression of @entity7 ( @entity7 ) induces subepithelial @entity82 associated with angiogenesis in @entity1 with @entity565 . @entity556 is recognized as a new candidate mediating airway remodeling. Therefore, this study was designed to determine the role of up-regulated @entity556 activity induced by @entity7 on airway remodeling in @entity1 with @entity565 . METHODS: Levels of biochemical parameters in induced sputum were examined in 21 @entity748 @entity1 and 11 normal control subjects. RESULTS: @entity556 activity in induced sputum was significantly higher in @entity748 @entity1 than in normal control subjects: median, 3.67 U/mL; range, 1.15 to 10.2 U/mL; vs median, 1.26 U/mL; range, 0.93 to 2.42 U/mL (p < 0.0001). In contrast, protein C activity in induced sputum was lower in @entity748 @entity1 than in normal control subjects: median, 20%; range, 5 to 30%; vs 41%; range, 30 to 59% (p < 0.0001). @entity7 level in induced sputum was positively correlated with @entity556 activity in @entity748 @entity1 (r = 0.55, p = 0.02), while inversely correlated with protein C activity (r = - 0.57, p = 0.01). Levels of @entity540 ( @entity540 ), a major profibrotic factor, were also significantly higher in @entity748 @entity1 than in normal control subjects. Moreover, @entity556 activity was significantly correlated with @entity540 level in @entity748 @entity1 (r = 0.67, p = 0.003). CONCLUSIONS: Increase in @entity7 level leads to up-regulation of @entity556 activity in @entity748 airways, and this elevated @entity556 activity induces elevation of @entity540 level. It will become to be a new strategy of @entity565 therapy to attenuate @entity556 activity for the regulation of airway remodeling.
