Synergistic effect of XXXX and cytoxan in reducing lung metastases.

@entity5 @entity35 @entity7283 @entity1229
Lung metastasis is a frequent @entity5 complication resulting in significant mortality. This study evaluates the effect of @entity1229 and cytoxan alone and in combination on lung metastases in @entity35 challenged with @entity7283 3924A. Seventy-seven male American @entity5 Institute (ACI) @entity35 weighing 200 g were studied. Thirty-seven @entity35 received @entity1229 orally for six days, which resulted in a prothrombin time 2 times that of controls (30 sec). All @entity35 received 1 X 10(5) clumped @entity7283 cells via tail vein injection. Animals were divided into four groups: Group I (controls, n = 20) received no antitumor treatment; group II @entity35 (n = 20) received 25 mg/kg cytoxan intraperitoneally at the time of @entity5 challenge; group III animals (n = 19) received @entity1229 alone; while group IV (n = 18) received both @entity1229 and cytoxan. @entity35 were evaluated for number of lung metastases and lung weight at 3 weeks postinjection. Data was subjected to statistical analysis by the Student's test. The mean number of lung metastases were 580 +/- 45 in group I, 350 +/- 310 in group II, 330 +/- 263 in group III, and 200 +/- 161 in group IV (P less than .005 [IV] v [I], P less than .05 [IV] v [II], [III]), (P less than .05 [II] v [I]), (P less than .05 [III] v [I]). Mean lung weights were 2.597 g +/- 1.65 in group I, 2.049 g +/- 0.75 in group II, 1.898 g +/- 0.80 in group III, and 1,677 g +/- 0.31 in group IV. (P less than .025 [IV] v [I], P less than .05 [IV] v [II]).(ABSTRACT TRUNCATED AT 250 WORDS)
