Longitudinal volumetric computed tomographic analysis of regional brain changes in normal aging and XXXX .

@entity1 @entity2504 @entity73 @entity2948 @entity195
OBJECTIVE: This study used a semiautomated image analysis technique to quantify the rate and regional pattern of cerebrospinal fluid (CSF) volume changes in the computed tomographic brain examinations of healthy adults and @entity1 with @entity195 ( @entity195 ). DESIGN: Longitudinal, within-subject design, with statistical correction for longitudinal method error (eg, head repositioning effects). SETTING: Palo Alto ( @entity2948 ) Department of Veterans Affairs Medical Center. @entity1 AND OTHER @entity1 : The 41 @entity1 with @entity195 were recruited from the Geriatric Psychiatry Research Unit and the National Institute of Mental Health Clinical Research Center of the Palo Alto Department of Veterans Affairs Medical Center. The 35 healthy control subjects were recruited from the local community. MAIN OUTCOME MEASURES: Cerebrospinal fluid volumes estimated from computed tomographic scans. RESULTS: Even after accounting for an estimate of method error (eg, head positioning effects) across computed tomographic examinations, the @entity1 with @entity195 showed greater annual CSF volume increases than did the control group. This CSF volume enlargement was not uniform across brain regions of interest; rather, the @entity1 with @entity195 showed disproportionate volume increases in the ventricular system and the sylvian fissures. Greater CSF volume changes in the @entity1 with @entity195 were significantly associated with greater @entity73 on the Mini-Mental State Examination. Furthermore, younger @entity1 with @entity195 showed more rapid progression on computed tomographic scans than did older @entity1 . CONCLUSIONS: The rate of CSF volume enlargement is region specific, with the most marked annual rate of change occurring in the ventricular system and the sylvian fissures. In addition, younger @entity1 show more rapid progression in the @entity2504 regions of interest than do older @entity1 .
