EFFECT OF SEDATION ON CONTRAST-ENHANCED ULTRASONOGRAPHY OF THE SPLEEN IN HEALTHY XXXX .

@entity12691 @entity235 @entity9809 @entity67217 @entity1129 @entity6948 @entity1054
UNASSIGNED: Contrast-enhanced ultrasound of the spleen enables the dynamic assessment of the perfusion of this organ, however, both subjective and quantitative evaluation can be strongly influenced by sedative agent administration. The purpose of this prospective, experimental study was to test effects of two sedative agents on splenic perfusion during contrast-enhanced ultrasound of the spleen in a sample of healthy @entity235 . Contrast-enhanced ultrasound of the spleen was repeated in six healthy Beagles following a cross-over study design comparing three protocols: awake, @entity12691 0.2 mg/Kg intramuscular (IM), and @entity6948 500  g/m(2) IM. After intravenous injection of a phospholipid stabilized @entity9809 microbubble solution ( @entity67217  , Bracco Imaging, Milano, Italy), the enhancement intensity and perfusion pattern of the splenic parenchyma were assessed and perfusion parameters were calculated. Normal spleen was slightly heterogeneous in the early phase, but the parenchyma was homogeneous at a later phase. Sedation with @entity12691 did not modify perfusion of the spleen. @entity6948 significantly reduced splenic enhancement, providing diffuse parenchymal hypoechogenicity during the entire examination. Measured parameters were significantly modified, with increased @entity1054 ( @entity1129 ; ( < 0.0001) and @entity1054 ( @entity1054 ; P < 0.0001), and decreased peak intensity (PI; P = 0.0108), wash-in (P = 0.0014), and area under the curve (AUC; P = 0.0421). Findings supported the use of @entity12691 and contraindicated the use of @entity6948 as sedatives for splenic contrast ultrasound procedures in @entity235 . Short-term and diffuse heterogeneity of the spleen in the early venous phase was determined to be a normal finding.
