Effect of cerebroventricular perfusion of XXXX on gastrointestinal myoelectric activity.

@entity235 @entity1425 @entity6138
The effect of intracerebroventricular (i.c.v.) perfusion of @entity6138 (BBS) on the interdigestive migrating myoelectric complex (MMC) activity was examined in conscious @entity235 with electrodes implanted on the stomach and small intestine. Cannulas and a catheter were chronically positioned in the lateral and fourth cerebral ventricles, respectively. i.c.v. perfusion of BBS, which failed to increase plasma BBS levels, replaced phase I activity in the stomach and duodenum by intense irregular spike activity and decreased the occurrence rate of MMCs, whereas intravenous infusion of BBS evoked phase II-like activity, mainly in the jejunum and ileum, and suppressed phase III activity. These data suggest that the effect of i.c.v. administration of BBS was mediated by direct activation of central brain structures. During i.c.v. perfusion of BBS, cycling in plasma levels of motilin persisted even when phase III activity was absent and plasma levels of @entity1425 rose significantly. @entity1425 infusion, however, did not affect myoelectric gastrointestinal activity except for prolonging phase II. Thus it is unlikely that the central action of BBS is exerted by motilin or @entity1425 .
