Correlation of radiotherapeutic parameters and treatment related morbidity in XXXX --analysis of RTOG study 75-06.

@entity1 @entity263 @entity1494 @entity294 @entity130
Treatment related morbidity, recorded in @entity1 entered onto a RTOG phase III study (testing the value of periaortic irradiation in locally advanced @entity263 ), has been correlated with radiotherapeutic parameters to identify and quantify the relationship with treatment volumes, doses, and techniques. Between 1976 and 1983 a total of 526 analyzable cases were entered onto the study. The study design entailed randomization to either pelvic irradiation followed by a prostate boost or pelvic and periaortic irradiation followed by a prostate boost. Periaortic irradiation was not associated with a significantly increased incidence of @entity130 manifested by @entity294 . No correlation between the total dose to the regional lymphatics (ranging from 4400 to 5100 cGy) and the incidence of bowel and @entity1494 could be established. Doses to the prostate in excess of 7000 cGy have not resulted in a significantly increased incidence of @entity1494 , but have been associated with a significant increase in the incidence of @entity130 manifested by @entity294 . The techniques of pelvic irradiation did not seem to significantly influence the incidence of bowel or @entity1494 . The technique of delivery of the prostatic boost did seem to influence the incidence of @entity130 . This refers to the lateral boost technique and the perineal boost technique which have been associated with a higher incidence of @entity294 . All of the conclusions based on this analysis are applicable only to treatment volumes and dose ranges used in this study and to conventional fractionation of 180 to 200 cGy per day.
