Continuous versus intermittent infusion of @entity2176 in adult XXXX : A systematic review and meta-analysis.

@entity4609 @entity1 @entity2176
UNASSIGNED: Continuous infusion of @entity2176 ( @entity4609 ) and intermittent infusion of @entity2176 (IIV) are two major administration strategies in clinical settings. However, previous articles comparing the efficacy and safety of @entity4609 versus IIV showed inconsistent results. Therefore, a meta-analysis was conducted to compare the efficacy and safety of @entity4609 and IIV. PubMed, the Cochrane Library and Web of Science up to June 2015 were searched using the keywords ' @entity2176 ', 'intravenous', 'parenteral', 'continuous', 'intermittent', 'discontinuous', 'infusion', 'administration' and 'dosing'. Eleven studies were included in the meta-analysis. Neither heterogeneity nor publication bias were observed. @entity1 treated with @entity4609 had a significantly lower incidence of nephrotoxicity compared with @entity1 receiving IIV [risk ratio (RR)=0.61, 95% confidence interval (CI) 0.47-0.80; P<0.001]. No significant difference in treatment failure between the two groups was detected. Mortality between @entity1 receiving @entity4609 and @entity1 receiving IIV was similar (RR=1.15, 95% CI 0.85-1.54; P=0.365). This meta-analysis showed that @entity4609 had superior safety compared with IIV, whilst the clinical efficacy was not significantly different. A further multicentre, randomised controlled trial is required to confirm these results.
