Correlation between serum exosome derived XXXX and acute coronary syndrome.

@entity1 @entity16381
OBJECTIVE: To explore the correlation of miRNAs with clinical characteristics of ACS. METHODS: 50 ACS @entity1 and 50 healthy controls were randomly selected. On the basis of miRNA expression levels, ACS @entity1 were classified as low miRNA expression group (fold change: <3) and high miRNA expression group (>= 3). RESULTS: @entity16381 expression increased markedly in the serum exosomes of ACS @entity1 , and @entity16381 expression in the serum of ACS @entity1 was also significantly higher than that in healthy controls. However, the sensitivity of serum @entity16381 was inferior to that of exosome @entity16381 . Analysis of clinical characteristics showed the mean age of 500 ACS @entity1 was 62.35  9.70 years, and there were 300 @entity1 in low @entity16381 expression group and 200 @entity1 in high @entity16381 expression group. When compared with low @entity16381 expression group, @entity1 with high @entity16381 expression were older, and had higher Killip class, higher CK-MB peak, higher cTnT peak and elevated LDL (P<0.05). Within 1-year follow up, 32 @entity1 died including 10 in low @entity16381 expression group with the mortality of 3.3% and 22 in high @entity16381 expression group with the mortality of 11.0%. Kaplan-Meier survival analysis revealed that the 1-year survival rate reduced significantly in @entity1 with high @entity16381 expression. CONCLUSION: miRNA-208a expression is significantly up-regulated in the serum exosomes of ACS @entity1 and is crucial for the diagnosis of ACS.
