Association between the XXXX Genetic Polymorphism @entity45987 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls.

@entity43 @entity788 @entity0 @entity2220 @entity5 @entity2 @entity11 @entity45987 @entity14 @entity2215 @entity420 @entity320
BACKGROUND: Several recent studies have identified that the @entity2215 genetic polymorphism @entity45987 is associated with @entity5 risk, but presented inconsistent results. We investigated these inconclusive results by performing a meta-analysis to systematically evaluate the association. METHODS: We conducted a search in PubMed, Google Scholar and ISI Web of Science to select studies on the association between @entity2215 @entity45987 and @entity5 risk. We conducted a stratified analysis using @entity5 type, ethnicity and source of controls. We calculated the odds ratios (OR) and 95% confidence intervals (CI). Article quality, heterogeneity, sensitivity, publication bias and statistical power were also assessed. RESULTS: 26 articles covering 76 108 cases and 134 215 controls met our inclusion criteria. A significant association between @entity2215 @entity45987 allele A and @entity5 susceptibility was demonstrated under a per-allele risk analysis (OR = 1.08, 95% CI = 1.04-1.13). Stratification analysis revealed an increased @entity5 risk in subgroups of @entity11 , @entity2 and @entity43 . No significant increase was found in @entity320 , @entity0 , @entity788 and @entity14 . In a subgroup analysis of @entity2 , a statistically significant increase was only observed in @entity420 . Moreover, a stratified analysis performed for ethnic groups revealed that the significant increase was only observed in Caucasians, whereas a non-significant increase was found in Asians. CONCLUSIONS: This meta-analysis suggests that the @entity2215 genetic polymorphism @entity45987 is associated with increased risk of @entity11 , @entity2220 and @entity43 among Caucasians. Further functional studies are warranted to validate this association and investigate further.
