Time-dependent effects of safflower oil to improve glycemia, XXXX and blood lipids in @entity28 , post-menopausal @entity1 with @entity164 2 @entity6 : a randomized, double-masked, crossover study.

@entity1 @entity32 @entity6 @entity28 @entity164 @entity2412 @entity4722 @entity165 @entity1851
BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .
