Effects of rTMS on XXXX : a longitudinal fMRI study.

@entity1 @entity2003 @entity43113 @entity191 @entity2845 @entity400 @entity717
@entity191 is a @entity717 whose principal symptoms are @entity400 , @entity2003 , @entity2845 and postural instability. Initially, drugs like L: -dopa or dopaminergic agonists are able to control these symptoms, but with the progress of the disease these drugs become less effective. Previous studies have reported that repetitive transcranial magnetic stimulation (rTMS) can improve these motor symptoms. The objective of this study was to investigate the neural mechanisms through which 25 Hz rTMS may improve motor symptoms in @entity191 . In a double-blind placebo-controlled study, we evaluated the effects of 25 Hz. rTMS in 10 @entity191 @entity1 . Fifteen rTMS sessions were performed over the primary cortex on both hemispheres (one after the other) during a 12-week period. The @entity1 were studied using functional magnetic resonance imaging during performance of a simple tapping and a complex tapping @entity43113 week before the administration of the first rTMS session and just after the last session. rTMS improved @entity2845 , while functional magnetic resonance imaging showed different cortical patterns in prefrontal cortex when @entity1 performed the complex tapping test. Furthermore, the improvement in @entity2845 is associated with caudate nucleus activity increases in simple tapping. Finally, we observed a relative change in functional connectivity between the prefrontal areas and the supplementary motor area after rTMS. These results show a potential beneficial effect of repetitive transcranial magnetic stimulation on @entity2845 in @entity191 which is substantiated by neural changes observed in functional magnetic resonance imaging.
