The Outcome of Philadelphia XXXX : Characteristics and Prognosis.

@entity1 @entity2008 @entity981
PURPOSE: The Philadelphia (Ph) chromosome is a well- known @entity2008 in adults with B-lineage @entity981 , and is associated with a poor prognosis. This study compared the clinical manifestations and prognosis in adult Ph-positive and Ph-negative @entity981 @entity1 . MATERIALS AND METHODS: We retrospectively analyzed the clinical records of adult @entity1 newly diagnosed as B-lineage @entity981 , between January 1995 and February 2001. Fifty five @entity1 were included in this study. We divided the @entity1 into Ph-positive and Ph-negative groups. RESULTS: Eighteen of the 55 @entity1 (32.7%) were found to have the Ph chromosome. At initial diagnosis, the Ph-positive @entity1 had higher circulating leukocyte counts, lower platelet counts and had a greater tendency to bleed, than the Ph-negative group. The complete remission rates were 83.3% and 83.8% for the Ph-positive and the Ph-negative groups, respectively. Four of the Ph-positive, and 13 of the Ph-negative, @entity1 underwent allogenic bone marrow transplantation. The median follow-up for the surviving @entity1 was 39.3 months. The three-year survival rates were 10.4% and 51.8% for the Ph-positive and the Ph-negative groups, respectively. The median disease-free survival was 7.7 months for the Ph-positive group, but did not reach the median value in the Ph-negative group. Among the Ph-positive @entity1 , age was the only factor that had an impact on the disease outcome. CONCLUSION: In adult B-lineage @entity981 , the Ph-positive @entity1 had similar complete remission rates to other @entity1 ; however, the remission was of shorter duration, with a higher relapse rate in the Ph-positive @entity1 . More effective treatments are needed to improve the survival of the Ph-positive @entity1 .
