Effects of different antihypertensive drugs on plasma @entity2002 in @entity101 XXXX .

@entity1 @entity2002 @entity972 @entity101 @entity918 @entity1674 @entity3591 @entity3593 @entity1011 @entity2165 @entity413 @entity165 @entity414
1. In order to evaluate whether treatment with different antihypertensive drugs would affect plasma @entity2002 levels, 118 mild to moderate essential @entity101 subjects, all males, aged 18 to 65 years, were randomly treated with @entity3591 10 mg, @entity2165 100 mg, @entity918 25 mg or @entity3593 20 mg, all given once daily for 8 weeks. 2. Before and after 8 weeks' treatment, blood pressure (BP), heart rate (HR), @entity2002 , total @entity165 (TC), HDL-C, LDL-C, @entity1674 (TG), plasma @entity413 , plasma @entity414 , serum @entity1011 and serum @entity972 were evaluated. 3. All four medications significantly reduced BP values, although the BP lowering effect of @entity3593 , @entity3591 and @entity2165 was significantly greater compared with that of @entity918 . 4. Plasma @entity2002 levels were unaffected by @entity2165 , @entity918 and @entity3591 , whereas they were significantly decreased by @entity3593 (-11.2%, P = 0.002). This @entity2002 lowering effect was more evident in smokers (-17.7%) than in non smokers (-7.4%). 5. @entity2165 and @entity3591 did not significantly affect plasma lipids, @entity918 increased TC, LDL-C and TG and reduced HDL-C; @entity3593 increased HDL-C and decreased TC and LDL-C. 6. @entity918 increased plasma @entity413 and @entity414 concentrations, which were unaffected by the other drugs. The diuretic also reduced serum @entity972 . 7. The results of this study indicate that @entity3593 reduces levels of plasma @entity2002 and confirm that different antihypertensive drugs may elicit different metabolic effects, which may variously influence the overall risk profile of the @entity101 @entity1 .
