Persistent remodeling of resistance arteries in type 2 XXXX patients on antihypertensive treatment.

@entity1 @entity101 @entity6 @entity934
We hypothesized that resistance arteries from @entity6 @entity1 with controlled @entity101 have less remodeling than vessels from untreated @entity101 subjects. Eight normotensive subjects (aged 44+/-3 years, 3 @entity1 ; values are mean+/-SEM), 19 untreated @entity101 subjects (46+/-2 years, 9 @entity1 ), and 23 @entity101 subjects with @entity6 under antihypertensive treatment (58+/-1 years, 15 @entity1 ) were studied. Resistance arteries dissected from gluteal subcutaneous tissue were assessed on a pressurized myograph. Most @entity6 @entity1 (70%) were being treated with angiotensin-converting enzyme inhibitors. Although systolic blood pressure was still above the normotensive range in these @entity1 (144+/-2 versus 150+/-3 mm Hg in @entity101 and 114+/-4 mm Hg in normotensive subjects), diastolic blood pressure was well controlled (83+/-2 mm Hg) and significantly lower compared with that in untreated @entity101 (100+/-1 mm Hg; P<0.001) but higher than in normotensives (76+/-3 mm Hg; P<0.05). Thus, pulse pressure was higher in @entity6 @entity1 (P<0.05). The media-to-lumen ratio of resistance arteries was greater in @entity101 (0.083+/-0.002) compared with normotensive controls (0.059+/-0.003; P<0.05) and was even higher in @entity6 @entity101 subjects (0.105+/-0.004; P<0.001 versus normotensive controls). The medial cross-sectional area was greater in @entity6 and @entity101 @entity1 compared with normotensive controls (P<0.001). @entity934 -induced relaxation was impaired in vessels from @entity101 @entity1 and from @entity1 with both @entity6 and @entity101 (P<0.05 versus normotensive controls), whereas endothelium-independent vasorelaxation was similar in all groups. Despite effective antihypertensive treatment, resistance arteries from @entity101 @entity6 @entity1 showed marked remodeling, greater than that of vessels from untreated, nondiabetic, @entity101 subjects, in agreement with the high cardiovascular risk of subjects suffering from both @entity6 and @entity101 .
