Effect of ultra violet irradiation on the interplay between XXXX and @entity61 lymphocytes.

@entity1087 @entity1569 @entity19 @entity1618 @entity61 @entity630 @entity484
Although ultraviolet (UV) radiation is used to treat several types of diseases, including rickets, @entity1569 , @entity484 , and @entity1087 , the prolonged exposure to its radiation may result in acute and chronic health effects particularly on the skin, eyes, and the immune system. AIM: This study was carried out to show the effect of UV on both of the lymphoproliferative response and their capacity to produce IL-12 and @entity1618 in @entity19 . METHODS: @entity19 were exposed to whole body UVB and tested for the effect of recovery times on lymphocyte proliferation and cytokine production. In addition, direct irradiation of spleens and lymphocyte suspension was carried out. Basal and mitogens-stimulated lymphocyte proliferation was assessed by MTT assay while @entity1618 and IL-12 were measured using ELISA. RESULTS: There was a significant suppression in lymphocyte proliferation in comparison with control. IL-12 level was significantly reduced while the level of @entity1618 was increased. Con A and PWM mitogens had no significant changes in @entity1618 while Con A caused a highly significant increase in IL-12 at day 6 of recovery in UVB body irradiation. CONCLUSION: Exposure to UVB radiation could cause a state of immune suppression and shifts @entity630 / @entity61 cell response. This effect is closely associated with the reduction of @entity630 cytokines' expression and increase in @entity61 cytokines' levels.
