Comparison of Acoustic Structure Quantification (ASQ), shearwave elastography and histology in XXXX with diffuse hepatopathies.

@entity1 @entity82 @entity132 @entity1560 @entity409
BACKGROUND: Objective of the study was to evaluate the diagnostic value of novel ultrasonographic modalities in comparison with simultaneously performed liver biopsy. METHODS: The results of simultaneously performed examinations using Acoustic Structure Quantification (ASQ), Virtual Touch Imaging and Quantification (VTIQ) and Virtual Touch Tissue Quantification (VTTQ) were compared with the findings of liver biopsy in @entity1 with a wide variety of diffuse hepatopathies (n = 51). The histologically determined @entity82 stage according to Desmet and Scheuer was compared with quantitative measurements returned by the ultrasonographic imaging modalities. RESULTS: No statistically significant correlation with histologically determined @entity82 stage could be identified for any measurements returned using ASQ. Increasing severity of @entity1560 , however, was associated with a reduction in the @entity132 ( @entity132 ) ratio (r =   -0.55; p < 0.0001). The shearwave velocities measured using VTTQ satisfyingly correlated with @entity82 stage (r = 0.56; p > 0.0001). @entity82 stages > F2 were associated with an area under the curve (AUC) of 0.94 (95%-CI:0.84-0.99). A cut-off value for shearwave velocity of 1.66 m/s was determined with a sensitivity of 100% and a specificity of 84 %. VTIQ showed a less pronounced but acceptable correlation with @entity82 stage (r = 0.35; p = 0.0154). For @entity82 stages > F2 analysis showed an AUC of 0.84 (95%-CI:0.70-0.93). The cut-off value was 1.82 m/s with a sensitivity of 100% and a specificity of 58 %. CONCLUSION: While ASQ showed no diagnostic advantage in our @entity1 collective, VTTQ showed high reliability for determining severe liver @entity82 in a group of @entity1 with diffuse @entity409 of different etiology.
