Multipotent Bone Marrow Stromal Cell Therapy Promotes Endogenous Cell Proliferation Following XXXX .

@entity64 @entity2806 @entity5219 @entity35 @entity385
UNASSIGNED: Despite extensive research over the years, there still exists some debate as to what constitutes the optimal therapeutic strategy to promote recovery following @entity64 . Due to the complexity of injured brain pathophysiology, treatment approaches should ideally address numerous factors, ultimately aiming to promote tissue protection, axonal regrowth and functional recovery. In this study we extend our understanding of the effects of bone marrow stromal cell (BMSC) treatment following experimentally induced @entity385 in @entity35 . Focal @entity2806 was experimentally induced in @entity35 by placing a preformed clot into the middle cerebral artery. Animals were injected intravenously with BMSCs at 24 hr after @entity64 and were sacrificed 7 days post injury. When administered BMSCs following @entity64 , neurological outcome was significantly improved relative to controls. There was an increase in the number of BMSCs labelled with BrdU present in the injured hemisphere of the brain compared to the non-injured side. Furthermore, administration of BMSCs also led to increases in @entity5219 , vascularization and endogenous proliferation. These findings provide insight into the mechanisms of action of BMSC treatment and further argue for the therapeutic potential of BMSCs as an effective treatment following @entity64 . This article is protected by copyright. All rights reserved.
