The XXXX in a memory clinic population: Relation with clinical profile and prognosis.

@entity1 @entity455 @entity303 @entity73 @entity209
BACKGROUND: The @entity209 ( @entity209 ) refers to a cluster of cardiovascular risk factors that is associated with an increased risk of @entity73 and @entity303 . It is unclear however, if the presence of the @entity209 is associated with a particular clinical profile or a different prognosis in @entity1 with @entity73 or early @entity303 . OBJECTIVES: To compare 1) the clinical profile and 2) the prognosis of @entity1 attending a memory clinic according to the presence or absence of @entity209 . DESIGN: Longitudinal cohort. SETTING: Memory clinic. @entity1 : We included and followed 86 consecutive @entity1 (average age of 66.7 (SD 9.7)) from the Amsterdam @entity303 Cohort with an MMSE>22. MEASUREMENTS: Clinical profile (neuropsychological examination, brain MRI, cerebrospinal fluid (CSF) biomarkers, clinical diagnosis) on an initial standardized diagnostic assessment was compared according to @entity209 status. Progression to @entity303 was assessed in initially nondemented @entity1 (subjective complaints n=40, mild @entity73 n=24, follow-up available in 59). RESULTS: 35 (41%) @entity1 met the @entity209 criteria. Demographics were similar between @entity1 with or without the @entity209 . At baseline, diagnosis, cognitive performance, severity of @entity455 on MRI, and CSF amyloid and tau levels did not differ between the groups (all p>0.05). Among nondemented @entity1 , however, @entity209 was associated with worse performance on executive function, attention _ speed and visuoconstructive ability (z-scores, p<0.05). During a mean follow-up of 3.4years a similar proportion of @entity1 with (4; 17%) and without (6; 17%) the @entity209 progressed to @entity303 (p=0.45). CONCLUSION: Among nondemented @entity1 presenting at a memory clinic @entity209 was associated with slightly worse cognitive performance (worse on tasks assessing executive functions, visuo-constructive ability, attention _ speed), but conversion rate to @entity303 was not increased.
