[Multicenter observational study of the effect of XXXX on the general well-being of adults with @entity302 ].

@entity1 @entity410 @entity146 @entity2051 @entity302
AIMS: An open label, national, multicenter, observational study had been conducted to evaluate of psychological general well-being in adults with therapy resistant @entity302 taking @entity2051 in Hungary. The possibility was examined to differentiate the improvement of the psychic well-being caused by the better status of the @entity410 disorder or caused by the psychopharmacological effect of the @entity2051 (in the next: OXC). METHODS: 528 @entity1 were asked to fill the Hungarian validated version of Psychological General Well-Being Schedule (PGWB), English version created by Harold J. Dupuy in 1984, at the baseline visit and after 12- week long duration OXC therapy regim. Finally the data of 332 @entity1 could be evaluated per protocol, biostatistical analysis was carried out. RESULTS: Based on data of 332 @entity1 (per protocol population) the OXC treatment significantly (p < 0.0001) improved all items of PGWB in clinically well-controlled (responder) @entity302 @entity1 and improved affective markers of @entity1 with uncontrolled @entity302 also. In case of @entity1 suffering from uncontrolled @entity302 the increase of psychical wellbeing items score influenced by biological effects were higher than those influenced by external effects. CONCLUSIONS: It can be stated that the adopted PGWB test battery is reliable quantitative method to examine the psychological well-being of @entity1 suffering from @entity302 . It was observed that OXC has significant psychopharmalogical effect besides the well-known anticonvulsive property among large Hungarian population of partial @entity302 patiens. In case of OXC therapy the positive psychic effect of the successful anticonvulsive treatment and the stabilization property on the affectivity of @entity302 @entity1 significantly separates. The OXC has no indication for the treatment of @entity146 conditions.
