Overexpression of cyclooxygenase-2 in XXXX .

@entity1 @entity6253 @entity5 @entity2 @entity1149 @entity9859 @entity2247 @entity151 @entity420
Evidence is accumulating to suggest that the inducible isoenzyme of cyclooxygenase (COX)-2 is up-regulated in @entity1 @entity5 and epidemiological studies indicate that COX inhibitors may have a protective effect on the development of @entity2 . We used immunohistochemistry and Western blotting to investigate COX expression in @entity5 specimens and three @entity2 cell lines. Sixty-five archival lung tissue samples, including 46 squamous cell and 6 @entity420 lung resections, and 13 @entity151 ( @entity151 ) biopsies were studied. Dense and intense cytoplasmic @entity2247 staining was found in all 52 resections from @entity1149 ( @entity1149 ). The staining was diffuse and much stronger than adjacent respiratory epithelium. @entity2247 staining was relatively weak in the majority of the @entity151 samples. The bronchial and bronchiolar epithelium in the surrounding normal lung structures showed uniform COX immunoreactivity with apical concentration of the stain. There was no increase in @entity9859 staining in any @entity5 type. Western blot analysis of the @entity5 lines revealed significantly higher expression of @entity9859 in CORL23 line and @entity2247 in two @entity1149 cell lines ( @entity6253 /P; A549) compared with the expression of @entity9859 and @entity2247 in cultured normal bronchial epithelial cells. Our findings demonstrated @entity2247 overexpression in @entity1149 .
