Asynchronization in Changes of Electrophysiology and Pathology of Spinal Cord Motor Neurons in XXXX Following Middle Cerebral Artery Occlusion.

@entity1 @entity64 @entity2500 @entity35 @entity528
BACKGROUND: Motor dysfunction is common in @entity64 @entity1 . Clinical electrophysiological studies suggest that @entity528 occurred in the lower motor neurons, while pathological evidence is lacked. This study aimed to combine the electrophysiological and pathological results to prove the existence of @entity528 in the motor system after @entity64 . METHODS: Modified neurologic severity score, electrophysiological, and pathological assessments were evaluated in @entity35 before @entity2500 ( @entity2500 ), and at 24 hours, 7 days, and 14 days after @entity2500 . Paired and independent-sample t-tests were applied to assess the changes of electrophysiological and pathological data. RESULTS: Compound motor action potential amplitude in the paretic side was significantly lower than the nonparetic side at both 24 hours (61.9    10.4 vs. 66.6    8.9, P < 0.05) and 7 days (60.9    8.4 vs. 67.3    9.6, P < 0.05) after @entity2500 . Motor unit number estimation of the paretic side was significantly less than the nonparetic side (379.0    84.6 vs. 445.0    89.5, P < 0.05) at 7 days after @entity2500 . Until 14 days after @entity64 , the pathological loss of motor neurons was detected. Motor neurons in 14-day @entity2500 group were significantly decreased, compared with control group (5.3    0.7 vs. 7.3    1.8, P < 0.05). CONCLUSIONS: Both electrophysiological and pathological studies showed @entity528 after @entity64 . This study identified the asynchronization in changes of electrophysiology and pathology. The abnormal physiological changes and function impairment can be detected in the early stage and recovered quickly, while the pathological loss of motor neuron can be detected only in a later stage.
