Recurrent XXXX after transplantation: Clinicopathological evaluation with protocol biopsies.

@entity1 @entity644 @entity1252 @entity1988 @entity1011 @entity393 @entity454
AIM: @entity1988 ( @entity1988 ) is an important complication of @entity1252 ( @entity1252 ). The aim is to use indication and protocol biopsies to determine clinicopathological findings and outcomes of @entity1 with @entity1988 undergoing kidney transplantation (KTx). METHODS: @entity1 who underwent KTx due to @entity1988 were retrospectively analyzed. Recurrent @entity1988 (RLN) was diagnosed by transplant kidney biopsy. RESULTS: Among 955 KTx @entity1 , 12 @entity1 with @entity1988 as the cause of @entity454 were enrolled. Five @entity1 were male. Mean follow-up time was 63        34   months. At the last follow-up visit, mean levels of serum @entity1011 and @entity644 were 137.0        69.0     mol/L and 0.26        0.26 gm/day, respectively. Eighteen indication and 22 protocol biopsies were performed; 27 of biopsies were additionally evaluated by immunofluorescence. In 2 recipients, subclinical RLN was confirmed by protocol biopsies. Clinical recurrence occurred in 4 @entity1 . Among @entity1 with RLN, time from diagnosis of @entity1988 to KTx was significantly shorter and use of ATG as induction treatment was significantly lower. @entity393 occurred in 2 recipients who had clinical RLN. Five-year overall graft survival was 85.7%. CONCLUSIONS: KTx is a reasonable option for @entity1 with @entity454 secondary to @entity1252 . However, recurrence of @entity1988 is not rare if protocol biopsies are included in posttransplantation surveillance. This article is protected by copyright. All rights reserved.
