Expression of XXXX , @entity3544 and @entity986 does not correlate with response to preoperative @entity356 .

@entity1 @entity986 @entity5 @entity3544 @entity900 @entity44742 @entity876 @entity356 @entity1487
BACKGROUND/AIMS: A retrospective evaluation was oerformed to determine whether the intensity of @entity876 , @entity3544 or @entity986 expression predicts response to preoperative chemoradiotherapy in locally advanced @entity356 . METHODOLOGY: Thirty-six @entity1 ( @entity44742 or N+) were studied. Preoperative treatment consisted of 30-45Gy of radiation with continuous @entity1487 and weekly @entity900 . Expression of @entity876 , @entity3544 and @entity986 in pretreatment biopsies was assessed by immunohistochemistry. Level of expression was determined from the intensity and extent of staining. @entity5 downstaging was defined as a reduction of at least one T-stage level and/or finding of intense @entity5 regression in histopathologic examination. RESULTS: Seventeen @entity1 responded to chemoradiation: 8 @entity1 had pathologic complete response, 9 @entity1 were downstaged. The multivariate analysis showed no significant influence of @entity876 (p = 0.76), @entity3544 (p = 0.10) nor @entity986 (p = 0.70) expression upon @entity5 response. Response was found in 52% of @entity1 with low, and in 40% of @entity1 with high @entity876 staining (p = 0.21); in 54% of @entity1 with low, and in 30% of @entity1 with high @entity3544 staining (p = 0.14); and in 48% of @entity1 with low, and in 43% of @entity1 with high @entity986 staining (p = 0.32). CONCLUSIONS: We found no significant influence of @entity876 , @entity3544 nor @entity986 expression upon response to preoperative chemoradiotherapy in @entity356 .
