Effect of intermittent and stepwise administration of XXXX -adrenergic agonist, L644,969, on @entity35 growth performance and skeletal muscles.

@entity35 @entity268 @entity5543 @entity1017
The effects of intermittent and stepwise administration of @entity5543 -adrenergic agonist, L644,969 on @entity35 growth performance and skeletal muscle growth were investigated in two studies. In experiment 1, 34 juvenile male @entity35 were randomly assigned to two treatment groups: (1) control, 0 ppm L644,969 for 21 days; (2) BL10, 10 ppm of L644,969 for 7 days, then 0 ppm L644,969 for another 7 days, plus 10 ppm of L644,969 for the final 7 days. L644,969 increased (P < 0.05) @entity1017 during the 7 day initial administration period. When L644,969 was withdrawn, no difference in @entity1017 was observed between the two groups. Re-administration of L644,969 after the withdrawal period increased (P < 0.01) @entity1017 up to 3 days of re-administration, but no effect was observed thereafter. In experiment 2, 18 juvenile female @entity35 were divided into three groups: (1) control, 0 ppm L644,969 for 22 days; (2) BL10, 10 ppm L644,969 for 22 days; (3) BL10-60, 10 ppm L644,969 for 11 days, then 60 ppm L644,969 for another 11 days. Feeding 10 ppm L644,969 increased (P < 0.05) the rate of @entity1017 up to 11 days, but not thereafter. Raising the dose of L644,969 from 10 to 60 ppm increased body @entity1017 during the initial 8 day period, but no effect was observed thereafter. Weights of skeletal muscles and heart were significantly increased by 10 ppm L644,969. Raising the dose to 60 ppm increased the mean skeletal muscle weights without statistical significance. Muscular concentration of @entity268 was significantly decreased by the long-term administration of L644,969.(ABSTRACT TRUNCATED AT 250 WORDS)
