Multivariate-analysis of prognostic factors in 232 XXXX with clinical stage-I @entity1204 using the new figo surgical staging system.

@entity1 @entity1204 @entity5 @entity3 @entity1349
A retrospective analysis is reported in 232 @entity1 with clinical Stage I @entity1204 diagnosed between 1980 and 1988, treated with combined surgery and adjuvant irradiation. @entity5 were restaged according to the FIGO (1988) surgical staging system (SSS) in order to assess the prognostic value of this revised classification and of the conventional clinico-pathological features (age, performance status, grade and depth of @entity3 ). The 5-year relapse-free survival (RFS) and @entity1349 ( @entity1349 ) of the series was 85% and 90.8%, respectively. Both 5-year RFS and @entity1349 were not significantly different adopting the FIGO (1971) clinical Stage (Stage IA 93% and 88% vs Stage IB 88.5 and 82%. respectively) whereas they were significant by FIGO SSS (Stage IA 96% and 93% vs Stage IB 94% and 88.5% vs Stage IC 74% and 63%, respectively) (p=0.001 and p=0.0005, respectively). Other factors that significantly affected 5-year RFS or @entity1349 at univariate analysis were age (p=0.01 and p<0.0001, respectively), performance status (p=0.035 and p=0.001, respectively), grade (p=0.015 and p<0.0001, respectively) and @entity3 (p=0.0017 and p=0.0003, respectively). A multivariate analysis of these prognostic variables showed that FIGO SSS was the only significant and independent (p=0.01) indicator for recurrence. However, when therapy was added to the model, FIGO SSS failed to retain significance (p=0.11). Concerning @entity1349 age (p<0.0001), performance status (p=0.04) and FIGO SSS (p=0.05) were significant and independent prognosticators, also when therapy was included in the analysis. In conclusion, this study shows that the new FIGO SSS is a useful prognosticator as well as is age and performance status, in early Stage @entity1204 .
