@entity10784 regulates angiogenesis and invasion phenotypes of XXXX .

@entity1 @entity10784 @entity1313 @entity7 @entity5 @entity11 @entity3 @entity463
UNASSIGNED: We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and angiogenic phenotypes, and demonstrated that @entity10784 is expressed at higher levels in @entity1 T-1 than @entity1 T-2 cells. The function of @entity10784 in relation to angiogenesis and invasion was investigated using these models. Stable silencing or overexpression of @entity10784 in @entity1 T-1 and @entity1 T-2 cells ( @entity1 T-1shA and @entity1 T-2A cells) was established and used. Thirty @entity1 @entity463 samples were evaluated for expression of @entity10784 , @entity7 ( @entity7 ) and platelet-derived growth factor (PDGF). Immunohistochemical and quantitative reverse-transcription polymerase chain reaction analyses revealed higher expression of @entity10784 , @entity7 and PDGF in @entity1 T-1 and @entity1 T-2A cells. Cultured @entity1 T-1 and @entity1 T-2A cells exhibited higher adhesive ability to endothelial cells. Histopathological analysis of animal @entity1313 revealed that J3T-1 and J3T-2A @entity5 displayed marked angiogenesis and invasion along the neovasculature, whereas J3T-2 and J3T-1shA @entity5 exhibited diffuse, infiltrative invasion without angiogenesis. Positive expression of @entity10784 was observed in @entity5 cells surrounding dilated vessels in 25/30 @entity1 @entity463 specimens. Our results reveal that the phenotype of @entity3 is closely related to angiogenesis. We identify @entity10784 as a factor regulating angiogenesis and invasion of @entity11 .
