Prognostic Significance of Statin Use in XXXX : A Systematic Review and Meta-Analysis.

@entity1 @entity5 @entity984 @entity12463 @entity14 @entity165
UNASSIGNED: Statin intake has been reported to reduce the risk of several @entity5 beyond its @entity165 -lowering effects. However, little is known regarding the survival benefit of statins for @entity1 with @entity14 ( @entity14 ).We conducted a systematic literature search of multiple databases for studies published before November 2014, which investigated associations between statin intake and @entity14 prognosis. Meta-analysis was performed using random-effects model. The primary outcomes of interest were @entity12463 ( @entity12463 ) and @entity5 -specific mortality (CSM).Ten studies involving 76,851 @entity1 were eligible for this meta-analysis, with 7 studies investigating prediagnosis statin use and 5 studies reporting postdiagnosis statin use. Prediagnosis statin use was associated with reduced @entity12463 (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.61-0.88, P=0.001) and CSM (HR 0.80, 95% CI 0.77-0.84, P<0.001) for @entity1 with @entity14 . This effect persisted when stratified by @entity5 site and in studies adjusted by nonsteroidal anti-inflammatory drug use. In addition, postdiagnosis statin use was associated with decreased CSM (HR 0.70, 95% CI 0.60-0.82, P<0.001). However, we did not note reduced @entity12463 for postdiagnosis statin use (HR 0.93, 95% CI 0.68-1.27, P=0.639). There appeared to be an association between postdiagnosis statin use and increased @entity12463 in @entity984 -mutated @entity14 .Our findings provide evidence that prediagnosis statin therapy was associated with reduced @entity12463 and CSM in @entity14 @entity1 ; postdiagnosis statin therapy indicated decreased CSM. However, findings may not apply to @entity1 with postdiagnosis statin therapy for @entity12463 . Further studies are warranted to determine the relation between statin dose and duration on @entity14 survival.
