XXXX Treatment Counteracts the Effect of @entity948 -Rich Diet on Matrix Metalloproteinase 9 Expression and @entity14185 Activation.

@entity35 @entity12149 @entity948 @entity1283 @entity53 @entity6929 @entity14185 @entity209 @entity65
UNASSIGNED: @entity948 -rich diet induces metabolic changes similar to those observed in @entity209 . Among other matrix metalloproteinases, @entity6929 has an important role in adverse cardiac remodelling and might have a role in the development of @entity65 associated with @entity209 . The changes of @entity6929 expression could be mediated via the @entity14185 pathway. In this study we investigated the effect of @entity948 -rich diet on @entity6929 expression in the heart of male and female @entity35 , along with the effect of @entity948 -rich diet and @entity53 on @entity6929 expression in ovariectomized females. We further assessed the effect of @entity948 -rich diet and @entity53 on @entity14185 activation, measured as the level of @entity12149 phosphorylation at Ser 276. The results showed that the diet regime did not affect the heart mass. Higher @entity6929 gene expression was found in cardiac tissue of male @entity35 fed the @entity948 -rich diet than in females on the same diet regime. In ovariectomized females, @entity948 -rich diet upregulated @entity6929 protein and mRNA expression in the heart, as well as phosphorylation of the @entity12149 subunit of @entity14185 at Ser 276. @entity53 replacement therapy reverted these changes in the heart of ovariectomized females. This study has shown that @entity53 could revert the early molecular changes in @entity6929 expression induced by @entity948 -rich diet that occurred before @entity1283 development by decreasing phosphorylation of the @entity14185 @entity12149 subunit at Ser 276.
