Heparin inhibits fibrin, but not leukocytes, in a model of XXXX .

@entity95 @entity1150 @entity1317 @entity715 @entity130
Previous studies with models of @entity1150 ( @entity1150 ) have demonstrated that leukocyte (PMN)-mediated @entity130 may be an initiating event in @entity1150 (14, 17). Since heparin (H) can prevent @entity1150 , we studied its effect on @entity1317 and @entity715 in our model. Three groups of @entity95 were treated with H either sc (73 and 147 U/kg) or iv (662 U/kg). Scanning electron microscopy revealed that the 73 U/kg sc dose was ineffective. All veins had PMN accumulation, fibrin deposition and complex @entity715 formation. There was no increase in anti-Xa activity; activated partial thromboplastin times (APTT) and whole blood clotting times were normal. The 147 U/kg sc and the intravenous dose did not inhibit PMN-mediated @entity130 . The endothelium was sloughed by migrating PMNs, basement membrane was exposed, and platelets adhered to it. @entity715 was completely absent in the iv dose group. This correlated with increased anti-Xa activity and prolonged APTT and whole blood clotting times. Our results indicate that heparin does not inhibit the PMN adhesion and migration which produces @entity1317 . However, the anticoagulant activity of heparin effectively reduces fibrin deposition and complex @entity715 formation.
