Angiogenesis-regulating microRNAs and XXXX .

@entity64 @entity2806 @entity26 @entity204 @entity385
@entity64 is a leading cause of @entity204 and disability worldwide. @entity385 is the dominant subtype of @entity64 and results from focal @entity2806 due to occlusion of major cerebral arteries. Thus, the restoration or improvement of reduced regional cerebral blood supply in a timely manner is very critical for improving @entity64 outcomes and poststroke functional recovery. The recovery from @entity385 largely relies on appropriate restoration of blood flow via angiogenesis. Newly formed vessels would allow increased cerebral blood flow, thus increasing the amount of @entity26 and nutrients delivered to affected brain tissue. Angiogenesis is strictly controlled by many key angiogenic factors in the central nervous system, and these molecules have been well-documented to play an important role in the development of angiogenesis in response to various pathological conditions. Promoting angiogenesis via various approaches that target angiogenic factors appears to be a useful treatment for experimental @entity385 . Most recently, microRNAs (miRs) have been identified as negative regulators of gene expression in a post-transcriptional manner. Accumulating studies have demonstrated that miRs are essential determinants of vascular endothelial cell biology/angiogenesis as well as contributors to @entity64 pathogenesis. In this review, we summarize the knowledge of @entity64 -associated angiogenic modulators, as well as the role and molecular mechanisms of @entity64 -associated miRs with a focus on angiogenesis-regulating miRs. Moreover, we further discuss their potential impact on miR-based therapeutics in @entity64 through targeting and enhancing post-ischemic angiogenesis.
