Absence of salivary XXXX in primary Sj  gren's syndrome.

@entity1 @entity17469
UNASSIGNED: @entity17469 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of @entity17469 in saliva of primary Sj  gren's syndrome (pSS) @entity1 in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS @entity1 and 30 non-smoker healthy controls paired by age (  5  years). Saliva samples were collected during the morning and kept frozen at -86    C until the analysis. Fifty microliters of saliva was diluted 3:1 with water and analyzed for @entity17469 salivary levels by ELISA method. The samples were tested in triplicate. IgA salivary levels were tested by ELISA method. We used descriptive statistics, Mann-Whitney U test and Kendall's tau correlation coefficients. pSS @entity1 were mostly females (93.3  %), mean age 54.5      13.3  years and median disease duration of 7.6  years (0.5-33). @entity1 with pSS had lower levels of salivary @entity17469 when compared with controls [0 (0-1,272  pg/ml) vs. 94.4 (0-5,810) pg/ml, p  <  0.0001]. pSS @entity1 also had lower median levels of salivary IgA [72.55   g/ml (0.40-297.4)] than controls [131.9   g/ml (6.8-281.8)], although the latter results did not reach statistical significance (p  =  0.51). Among the SS group, there was no correlation between @entity17469 and IgA salivary levels nor between salivary IgA and disease duration, salivary flow, serum immunoglobulins or dental loss. @entity17469 was absent in saliva of pSS @entity1 ; however, this finding did not correlate with salivary IgA levels.
