Evaluation of the pathologic and prognostic correlates of XXXX receptors in primary @entity0 .

@entity172 @entity1 @entity0 @entity5 @entity356
The presence of @entity172 receptors in @entity0 tissue has been reported to correlate with improved prognosis in @entity1 after mastectomy. The prognostic value (if any) of the presence or absence of @entity172 receptors (ER) in malignant breast tissue was evaluated 104 @entity1 who were treated for primary @entity0 , whose pathology was re-examined, and whose records were subjected to multifactorial analysis. Sixty @entity1 were ER positive, and 44 were ER negative, and a total of 94 who had curative resections were available for follow-up (mean follow-up time 20 months). The presence of @entity172 receptors showed significant positive correlations with @entity356 , and a variant of infiltrating duct @entity5 that is prevalent in the elderly and characterized by the presence of cells showing granular eosinophilic cytoplasm. Of 26 cases identified as infiltrating duct @entity5 showing granular eosinophilic cytoplasm, 22 were ER positive, one was ER negative, and three had borderline values. There was no significant difference between the groups with regard to family history of @entity0 or hysterectomy. A striking observation was noted in the ER positive group in which there were seven cases of second primary @entity0 , whereas no such cases occurred in the ER negative @entity1 (p=0.05). There was a higher percentage of nodal metastases in the @entity1 who were ER positive compared with those who were ER negative; 27 of 53 (51%) of the ER positive @entity1 has positive nodes compared with four of 40 (32%) who were ER negative, p = 0.08. There was no significant correlation of disease free survival nor time to recurrence in either the overall group nor according to stage. In @entity1 whose @entity5 had been reviewed and graded, there was no prognostic relationship of ER status in high grade @entity5 , but in @entity1 with low-grade @entity5 , improved disease-free survival was demonstrated in @entity1 who were ER negative. Although the @entity172 receptor assay is a highly useful @entity5 marker and guide for therapy of advanced @entity0 , its relationship to the prognostic variables of primary @entity0 is complex and controversial and merits continued study.
