Intestinal absorption of human insulin in XXXX using delivery systems based on superporous hydrogel polymers.

@entity1707 @entity11938 @entity413
In this in vivo study, novel delivery systems based on superporous hydrogel (SPH) and SPH composite (SPHC) polymers were used to improve the intestinal absorption of @entity11938 in healthy @entity1707 . Six female @entity1707 of approximately 35 kg body weight were used. A cannula was inserted into the jugular vein for blood sampling and a silicone fistula in the duodenum for administration of gelatin capsules containing the delivery systems or @entity11938 solutions. The delivery systems consisted of two components, (1) conveyor system made of SPH and SPHC; (2) core containing @entity11938 . The core was inserted either into the conveyor system (core inside, c.i.) or attached to the surface of conveyor system (core outside, c.o.). The following intestinal formulations were investigated: c.i., c.o. and intraduodenal (i.d.) administration of @entity11938 solutions. Subcutaneous (s.c.) injection of @entity11938 was also investigated for reasons of comparison. Blood samples were taken and analyzed for @entity11938 and @entity413 concentrations. Relative bioavalibility values of 1.3+/-0.4 and 1.9+/-0.7% were achieved for c.o. and c.i. administrations, respectively. The bioavalibility for i.d. administration of @entity11938 solution was 0.5+/-0.2%. These results indicate that the absorption of @entity11938 was slightly increased using SPH/SPHC-based delivery systems. Furthermore, a large variability was observed, probably due to physiological and metabolic changes during the experiments. Blood @entity413 levels were slightly decreased after the c.o. and c.i administrations, whereas these levels did not decrease after i.d. administration of @entity11938 solutions. In conclusion, SPH/SPHC-based delivery systems are able to enhance the intestinal absorption of @entity11938 and are, therefore, considered as promising systems for peroral peptide drug delivery. However, @entity11938 delivery from these delivery systems under in vivo have to be improved.
