Plasma XXXX concentration and iron status. Does the relationship exist in the elderly population?

@entity1 @entity32 @entity650 @entity58343 @entity11648 @entity1851
OBJECTIVE: @entity11648 ( @entity11648 ) is a phosphaturic agent involved in calcium-phosphate homeostasis. Recent findings show that @entity58343 and @entity32 regulate @entity11648 release and/or biodegradation. @entity58343 is frequently observed in the elderly, therefore the aim of this study was to find out if @entity58343 is independent from low grade inflammatory factors affecting both forms of @entity11648 that are detectable in circulation in a large population-based study of elderly subjects. DESIGN AND METHODS: The analysis included 3780 elderly (1798 females) PolSenior study @entity1 and assessed levels of phosphorus, calcium, iron, ferritin, @entity650 , @entity1851 (hs-CRP), intact (iFGF23), and c-terminal FGF (cFGF23). The analysis was performed for all subjects and terciles of serum iron levels in relation to hs-CRP were calculated. RESULTS: The highest plasma cFGF23 and iFGF23 concentrations were found in subjects with the lowest serum iron levels (p<0.001). The effect of low grade @entity32 was markedly weaker and affected only iFGF23 levels. The adjusted serum levels of hs-CRP, iPTH, phosphorus, and 25-(OH)-D3 analysis revealed that plasma iFGF23 and cFGF23 levels were almost unchanged up to a serum iron level of 59.3ng/mL and 57.3ng/mL respectively and then were nearly linearly increasing by 0.285pg/mL and 3.742RU/mL for each unit of serum iron increase. CONCLUSIONS: Low iron levels are associated with increased levels of both cFGF23 and iFGF23, independent of low grade @entity32 . A similar analysis of cFGF23 and iFGF23 does not suggest enhanced biodegradation of iFGF23 induced by @entity58343 .
