Left ventricular ejection time on echocardiography predicts long-term mortality in light chain XXXX .

@entity1 @entity712 @entity2783 @entity492 @entity493
OBJECTIVE: Light chain @entity2783 ( @entity2783 ) is associated with high mortality. The aim was to identify echocardiographic parameters that predict @entity2783 long-term mortality. METHODS: Forty-two subjects with biopsy-proven @entity2783 (43% were female; aged 61 +/- 12 years) underwent echocardiography and were followed 29 +/- 16 months (median 29.4 months). Standard echocardiographic and clinical parameters and @entity712 ( @entity712 ) class were tested using univariate/multivariable Cox proportional hazard regression analyses to identify markers of mortality. RESULTS: Twenty-three subjects died, with a 1-year mortality of 44%. Univariate predictors of mortality were @entity712 class (P < .001), left ventricular systolic ejection time (ET) (P = .002), alkaline phosphatase (P < .001), and @entity492 and @entity493 aminotransferase (P = .003 each). On multivariable analysis, only @entity712 class (hazard ratio [HR] 4.86; 95% confidence interval [CI], 1.58-14.9; P = .006), ET (10 ms increase; HR 0.87; CI, 0.78-0.97; P = .01), and alkaline phosphatase (10 U/L increase; HR 1.04; CI, 1.01-1.06; P = .01) were prognostic. ET <or= 240 ms had a sensitivity of 61% and a specificity of 90% in predicting 1-year mortality and a sensitivity of 73% and a specificity of 90% in predicting 1-year cardiac mortality. CONCLUSION: @entity2783 was associated with high long-term mortality. Among echocardiographic and clinical parameters, only ET and alkaline phosphatase had incremental value to @entity712 class in predicting mortality. This may be useful to identify high-risk @entity1 .
