NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of @entity209 in overweight XXXX : a double-blind, randomized, placebo-controlled study.

@entity1 @entity1674 @entity344 @entity209 @entity413 @entity165
The influence of dietary fiber on determinants of @entity209 is controversial. The objective of this study was to determine the effects of NUTRIOSE supplementation on insulin resistance and the determinants of @entity209 in overweight @entity1 . In this double-blind, randomized, placebo-controlled study, we supplemented the diets of overweight Chinese @entity1 with 250  mL of fruit juice that contained NUTRIOSE (Test group: n = 60, age = 30.4     4.3  years, body mass index (BMI) = 24.5     0.2  kg  m-2) or a maltodextrin placebo ( CONTROL GROUP: n = 60, age = 31.6     4.1  years, BMI = 24.5     0.3  kg  m-2) at a dosage of 17 g twice daily for 12  weeks. Daily caloric intake, body composition, blood chemistry, and blood pressure were evaluated every 4  weeks during the trial. Test subjects consumed fewer calories per day and had greater reductions in body weight, BMI, body fat percentage, and waist circumference than Control subjects. All markers of @entity413 metabolism improved in the Test group, with increases in adiponectin and reductions in @entity413 , insulin, homeostasis model assessment-estimated insulin resistance, glycosylated hemoglobin, and glycated albumin (all p  < 0.01). Similarly, all lipid measures improved with increases in high-density lipoprotein @entity165 and reductions in total @entity165 , low-density lipoprotein @entity165 , very low-density lipoprotein @entity165 , and @entity1674 (all p  < 0.01). No changes were observed in systolic blood pressure between groups. Most components of @entity413 metabolism and the lipid profile were significantly better in the Test than in the Control subjects. No adverse events or @entity344 were reported in either group. Supplementation with NUTRIOSE for 12  weeks is well tolerated, lowers insulin resistance, and improves determinants of @entity209 in overweight @entity1 .
