Prognostic importance of baseline and serial changes in microalbuminuria in @entity1 with resistant XXXX .

@entity1 @entity64 @entity101 @entity301 @entity633 @entity65
OBJECTIVE: The prognostic value of microalbuminuria is unsettled in resistant @entity101 . The objective was to evaluate the importance of baseline and serial changes in @entity633 as predictors of @entity65 and mortality in @entity1 with resistant @entity101 . METHODS: 531 resistant hypertensives had urinary albumin excretion rate (UAER) measured prospectively at baseline and at the 2nd year of follow-up. Primary endpoints were a composite of fatal and non-fatal cardiovascular events, all-cause and cardiovascular mortalities. @entity64 and @entity301 ( @entity301 ) events were secondary endpoints. Multiple Cox regression assessed the associations between UAER and endpoints. RESULTS: After a median follow-up of 4.9 years, 72 @entity1 died, 42 from cardiovascular causes; 96 cardiovascular events occurred, 42 @entity64 and 47 @entity301 events. After adjustment for several cardiovascular risk factors, baseline UAER, either analyzed as a continuous variable or dichotomized at different cut-off values, was an independent predictor of the composite endpoint, all-cause and cardiovascular mortality, @entity64 and @entity301 events. Each 10-fold increase in UAER implied a significant 1.6, 1.5, 2.0, 1.5 and 1.6-fold higher risk, respectively, for each of the above endpoints. Serial changes in microalbuminuria status during follow-up tended to parallel changes in cardiovascular risk, regression of microalbuminuria was associated with a 27% lower risk and development with a 65% higher risk of having a cardiovascular event. CONCLUSIONS: Baseline @entity633 strongly predicts @entity65 and mortality in resistant @entity101 @entity1 and serial changes in microalbuminuria may translate into changes in risk. Microalbuminuria reduction may be a goal of anti- @entity101 treatment.
