Severe @entity810 associated with non-steroidal anti-inflammatory drugs in XXXX : A case-control study.

@entity1 @entity32 @entity8 @entity82 @entity9719 @entity810 @entity3485 @entity1011 @entity21618
BACKGROUND _ AIMS: @entity32 ( @entity32 ) may cause @entity8 in @entity1 with @entity82 . Investigational studies demonstrated reversibility of @entity8 after drug withdrawal, but information based on clinical practice is lacking. The aim of the study was to investigate the characteristics and outcome of @entity810 ( @entity810 ) developing in @entity1 with @entity82 treated with @entity32 . METHODS: Prospective cohort study in a tertiary referral center of all @entity1 with @entity32 -associated @entity810 seen from 2002 to 2014. For comparison, three control groups of @entity1 with @entity3485 -induced @entity810 , type-1 @entity9719 and @entity21618 , respectively, were also evaluated. Urinary excretion of neutrophil gelatinase-associated lipocalin (uNGAL) was measured in a subset of @entity1 . RESULTS: Thirty @entity1 with @entity82 and @entity32 -associated @entity810 were identified. In 19 @entity1 (63%) @entity810 was @entity8 rapidly recovered (4  3days) after @entity32 withdrawal. In the remaining 11 @entity1 (37%) @entity810 was more severe and persisted during hospitalization despite drug withdrawal. @entity1 with persistent @entity810 had remarkably higher uNGAL levels compared with those of @entity1 with transient @entity810 (953  1,198 vs. 83  79 g/g of @entity1011 , respectively, p=0.008). Moreover, seven of the 11 @entity1 with persistent @entity810 (64%) died within three months compared with only one of the 19 (5%) @entity1 with transient @entity810 (p=0.001). Mortality of persistent @entity810 was similar in @entity32 @entity1 compared to control groups. The only independent predictive factor of three-month mortality was persistent @entity810 . CONCLUSIONS: @entity1 with @entity82 treated with @entity32 may develop severe @entity810 which may be irreversible and associated with poor short-term outcome.
