XXXX : a review of its use in dentistry.

@entity1 @entity137 @entity2627 @entity274 @entity2520 @entity2522 @entity1066 @entity5932 @entity273 @entity5951
Several dentifrices that contain @entity273 are currently being marketed. The increased use of bleaching agents containing (or generating) @entity274 prompted this review of the safety of @entity274 when used in oral hygiene. Daily exposure to the low levels of @entity274 present in dentifrices is much lower than that of bleaching agents that contain or produce high levels of @entity274 for an extended period of time. @entity273 has been used in dentistry alone or in combination with salts for over 70 years. Studies in which 3% @entity274 or less were used daily for up to 6 years showed occasional transitory irritant effects only in a small number of subjects with preexisting @entity1066 , or when high levels of salt solutions were concurrently administered. In contrast, bleaching agents that employ or generate high levels of @entity274 or organic @entity2627 can produce localized oral @entity137 following sustained exposure if mishandled. Potential health concerns related to prolonged @entity273 use have been raised, based on animal studies. From a single study using the hamster cheek pouch model, 30% @entity274 was referred to as a @entity5932 . This (and later) studies have shown that at 3% or less, no cocarcinogenic activity or adverse effects were observed in the hamster cheek pouch following lengthy exposure to @entity274 . In @entity1 , prolonged use of @entity273 decreased plaque and @entity2522 indices. However, therapeutic delivery of @entity274 to prevent @entity2520 required mechanical access to @entity5951 . Furthermore, wound healing following gingival surgery was enhanced due to the antimicrobial effects of topically administered @entity273 . For most subjects, beneficial effects were seen with @entity274 levels above 1%.
