Young Alzheimer XXXX show distinct regional changes of oscillatory brain dynamics.

@entity1 @entity195
The objective of this study was to examine the differences in oscillatory brain dynamics in @entity195 ( @entity195 ) according to age at onset using quantitative electroencephalography (EEG). We examined resting state electroencephalograms of 320 probable @entity195 @entity1 and 246 controls, both categorized into a young ( <= 65 years) and old (> 65 years) group. Relative power in 4 different frequency bands was calculated. The effect of age on global and regional relative power was examined. Globally, young @entity195 @entity1 showed lower alpha- and higher delta-power than old @entity195 @entity1 . Regional analysis showed that these differences were most pronounced in the parieto-occipital region. Young @entity195 @entity1 had lower beta- and higher theta-power than old @entity1 in all but the temporal regions. In controls, there was no age effect on global relative power in any frequency band. Young @entity195 @entity1 present with more severe slowing of spontaneous oscillatory activity than old @entity195 @entity1 , which is most pronounced in the posterior brain areas. This finding supports the hypothesis that early onset @entity195 presents with a distinct endophenotype.
