Late cardiac, thyroid, and pulmonary sequelae of mantle radiotherapy for XXXX .

@entity1 @entity1375 @entity296 @entity2845 @entity1001 @entity299 @entity978 @entity1374
Cardiac, thyroid and pulmonary function were evaluated in 25 @entity1 aged 35 years or under, treated for @entity978 by mantle radiotherapy 5-16 years previously. No @entity1 had symptoms of @entity299 . Although thallium myocardial perfusion scintigraphy was normal in all @entity1 , @entity296 were detected in 6 (24%) @entity1 using gated equilibrium rest and exercise radionuclide ventriculography. Resting left ventricular ejection fraction (LVEF) was abnormal in 1 @entity1 , and in 3 @entity1 there was an abnormal LVEF response to exercise. All 6 @entity1 had @entity1001 . @entity2845 was present in 4 of these @entity1 . A small asymptomatic pericardial effusion was detected by M-Mode echocardiography in only 2 (8%) @entity1 . Twenty-three (92%) @entity1 had evidence of @entity1374 . Two (8%) @entity1 had become clinically @entity1375 . Serum TSH was elevated in 13 (52%) @entity1 and TRH stimulation test was abnormal in a further 10 (40%) @entity1 in whom TSH was normal. Pulmonary function studies showed a moderate decrease in diffusing capacity (72% of predicted) and a minor reduction in lung volume. Although a high incidence of @entity299 was detected, only the 2 @entity1 who had become @entity1375 were symptomatic. Modification of the irradiation technique may reduce the incidence of @entity299 , but is unlikely to alter significantly the thyroid or pulmonary sequelae.
