XXXX : a clinicopathologic study.

@entity1 @entity32 @entity39 @entity1333 @entity30338 @entity8855 @entity1252 @entity9821 @entity730
BACKGROUND: @entity30338 is a clinical variant of @entity1252 which involves the deep dermis and the subcutaneous fat. The purpose of this study was to ascertain the clinical profile of Asian @entity1 with this condition. METHODS: This was a retrospective study of all histologically confirmed @entity30338 seen at our center between 1992 and 1997. The age, sex, past history/subsequent diagnosis of @entity1252 ( @entity1252 ), presence of clinical @entity9821 ( @entity9821 ) changes on overlying skin, direct immunofluorescence, serologic, and histologic findings were analyzed. RESULTS: There were 12 cases of @entity30338 , two of which were in @entity1 already diagnosed with @entity1252 and one in which the @entity1 subsequently evolved into @entity1252 . The mean age at diagnosis was 31.3 years. The face (50%), upper limbs (33%), and scalp (25%) were the most common sites of involvement. Thirty-three per cent had clinical evidence of @entity9821 on the overlying skin, whilst 67% had histologic features of @entity9821 on the overlying skin. A lupus band was present in 36%. Antinuclear antibody (ANA) was positive in three of 11 cases; these were in the two @entity1 who already had @entity1252 and in the only @entity1 who progressed to @entity1252 . All of the cases showed fat @entity39 and, in the majority of cases, there was associated lobular and @entity32 . Thirty-three per cent showed @entity1333 and 75% had mucin deposition. None had lymphoid nodules, @entity8855 , or @entity730 . CONCLUSIONS: @entity30338 affects a younger age group in Asians as compared with the Western population. Although about one-third of @entity1 show clinical evidence of overlying @entity9821 , two-thirds of @entity1 show histologic evidence of @entity9821 . It tends to have a mild disease course in the majority of cases.
