Healthcare resource implications of XXXX -related hospital admissions and inpatient @entity4053 : retrospective record-linked cohort studies in England.

@entity1 @entity164 @entity6 @entity4053
OBJECTIVE: Using a retrospective cohort study, the mean length of hospital stay (LoS) and total per- @entity1 expenditure for @entity4053 requiring admission to hospital were estimated. In a separate matched retrospective cohort study, the effect of inpatient @entity4053 on LoS, expenditure, and risk of all-cause mortality while admitted was investigated. METHODS: The cohorts consisted of @entity1 aged >= 18   years with a diagnosis of @entity164 1 or 2 @entity6 between January 1, 2002 and October 30, 2012 in the Clinical Practice Research Datalink database, who had initiated insulin treatment and had a recording of @entity4053 in the same period. In the matched retrospective cohort study, exposed @entity1 (who experienced @entity4053 in hospital) were case-matched with @entity1 who did not experience @entity4053 during admission (unexposed). Generalized linear regression was used to estimate LoS. Risk of all-cause mortality was evaluated via logistic regression. RESULTS: In the retrospective cohort study (1131 @entity1 ), mean LoS was 5.46 (95% CI 4.62  to 6.45) days for @entity164 1 @entity6 , and 5.04 (95% CI 4.46 to 5.71) days for @entity164 2 @entity6 . Mean cost per admission was   1034 (95% CI   855 to   1253). In the matched retrospective cohort study (1079 pairs of @entity1 ), exposed @entity1 had a mean LoS of 11.91   days (95% CI 10.96  to 12.94   days) versus 4.80 (95% CI 4.41  to 5.23) for unexposed @entity1 , p<0.0001. Exposed @entity1 had a higher mortality risk compared with unexposed @entity1 (OR 1.439 (95% CI 1.060to 1.952), p=0.0195). Total average per- @entity1 cost for exposed @entity1 was GBP (  )2235, 40% (p<0.0001) higher than total average admission cost in unexposed @entity1 . CONCLUSIONS: @entity4053 has a significant negative impact on @entity1 outcomes, healthcare resource use, and expenditure.
