The Use of Cryotherapy for XXXX and Early Laryngeal Cancers: Long-term Results.

@entity1 @entity16850 @entity5 @entity1185 @entity189
STUDY DESIGN: Retrospective chart review. OBJECTIVE: To determine the efficacy of adjuvant cryotherapy in the treatment of early @entity5 and @entity16850 . SUMMARY OF BACKGROUND DATA: The use of cryotherapy in conjunction with traditional modalities has recently been proposed to improve voice outcomes in @entity1 with early @entity5 as compared to pretreatment conditions. This study investigates its utility in improving oncological outcomes and decreasing recurrences of @entity16850 . METHODS: @entity1 with either early @entity5 or @entity16850 that received cryotherapy as part of their surgical regimen were investigated. All @entity1 were seen at a large tertiary care center within a 10-year window. Demographic data were collected and all postoperative notes were reviewed. Recurrences of the @entity5 were noted, as was the duration of time between successive @entity1185 operations. RESULTS: The charts of 54 @entity5 and 29 @entity1185 @entity1 that received cryotherapy were reviewed. One @entity1 from the @entity1185 cohort was excluded from statistical analysis due to lack of follow-up. Overall, 16 (30%) of the @entity5 @entity1 experienced a malignant recurrence. The overall 5-year survival of these @entity1 was 98% and the 5-year disease-free survival was 74%. The use of adjuvant cryotherapy in the treatment of @entity16850 extended the duration of time between surgeries by an average of 79 days (P = .23). CONCLUSION: The use of adjuvant cryotherapy in the treatment of early @entity5 does not improve the rate of @entity189 recurrences. Additionally, cryotherapy does not result in a statistically significant increase in the duration of disease-free period for @entity16850 @entity1 , although the observed increase may be clinically important.
