@entity8 in chronic aristolochic acid XXXX and protective effects of Cozaar.

@entity8 @entity6098 @entity26081 @entity42845 @entity21405 @entity34313 @entity18174 @entity71498 @entity35 @entity4124 @entity6667
BACKGROUND: To investigate the @entity8 in chronic @entity42845 @entity8 (AAN) and the protective effects of Cozaar. METHODS: Male @entity35 were randomized into three groups. @entity35 in the model group received Caulis Aristolochiae manshuriensis (CAM) decoction by gavage (10 mL/kg/day); those in the Cozaar group were gavaged with CAM and Cozaar (33.3 mg/kg/day); and those in the control group only received an equal daily volume of saline solution by gavage. Kidney tissues were observed under a light and electron microscope. @entity6098 , @entity4124 , and @entity21405 ( @entity21405 ) were determined by immunohistochemistry, and expressions of @entity71498 , @entity26081 , @entity21405 , and @entity6667 ( @entity6667 ) mRNA were monitored via real-time polymerase chain reaction (PCR). RESULTS: (1) The kidney tissue injury in the chronic AAN model group was apparent, compared to the normal structure in the normal control group, and the Cozaar group showed relieved injury. (2) The expression of @entity4124 in the model group was elevated, while expressions of @entity21405 and @entity6098 were decreased (p < 0.05). Cozaar lessened @entity4124 expression (p < 0.05) and promoted @entity21405 and @entity6098 expressions (p < 0.05). (3) Real-time PCR demonstrated a downregulation of @entity34313 , @entity26081 , @entity21405 , and @entity6667 mRNA (p < 0.05) and an upregulation of @entity18174 mRNA (p < 0.01) in the renocortex, while Cozaar upregulated the expression of @entity34313 , @entity26081 , @entity21405 , and @entity6667 mRNA (p < 0.05). CONCLUSION: @entity8 was observed in chronic AAN, which was hypothetically correlated with a lack in the expressions of @entity34313 , @entity21405 , @entity26081 , and @entity6667 and an excess in @entity4124 and @entity18174 . Cozaar can significantly ameliorate the @entity8 and protect renal function.
