OS009. Second trimester serum hyperglycosylated @entity1 chorionic gonadotrophin and XXXX .

@entity1 @entity101 @entity73 @entity3566 @entity1468
INTRODUCTION: Hyperglycosylated @entity1 chorionic gonadotrophin ( @entity3566 ), produced by the placental trophoblast cells, is involved in placental development in early pregnancy. Decreased second trimester urine @entity3566 is associated with @entity1468 , which may be a sign of @entity73 preceding symptoms of the disease. OBJECTIVES: To study whether maternal second trimester serum @entity3566 concentrations predict later development of @entity1468 . METHODS: Fifty-five @entity1 with subsequent @entity1468 , 21 @entity1 with gestational @entity101 , 30 normotensive @entity1 with small-for-gestational-age (SGA) @entity1 and 83 controls with uneventful pregnancies were included in the study. Their serum hCG and @entity3566 concentrations were analyzed by fluoroimmunoassay at 14-17weeks of gestation. The proportion of @entity3566 of total hCG (% @entity3566 ) was calculated and converted to multiples of the median (MoMs) of the controls. MoMs of the groups were compared by Mann-Whitney U test. Pearson's correlation was used to analyze correlations between clinical characteristics and serum marker concentrations. The results are given as medians with 95% confidence intervals (95% CI). A two-tailed P<0.05 was considered significant. RESULTS: The concentrations of @entity3566 and % @entity3566 decreased with advancing gestational weeks in @entity1 with subsequent @entity1468 (r=-0.289, p=0.032 and r=-0.464, p<0.001), but not in @entity1 in the other groups. There was a tendency towards lower concentrations of @entity3566 and % @entity3566 in @entity1 with subsequent @entity1468 than in controls. The median MoMs of % @entity3566 were 0.89 (95% CI,0.79-1.00) in @entity1 with subsequent @entity1468 and 1.00 (0.91-1.11) in controls. The corresponding values for @entity1 with subsequent gestational @entity101 were 1.00 (0.86-1.16), for those with subsequent SGA @entity1 they were 1.09 (0.89-1.23). The difference between @entity1468 and the other groups together was significant (p=0.029). CONCLUSION: Earlier studies suggest that decreased urine @entity3566 concentrations reflect changes in placental function that precede the development of @entity1468 . At 14-17weeks of gestation, the serum concentrations of @entity3566 showed moderate validity to predict later development of @entity1468 . Further studies on the utility of @entity3566 for prediction of subsequent @entity1468 are warranted.
