Usefulness of @entity460 antagonists for XXXX .

@entity1 @entity712 @entity308 @entity296 @entity235 @entity384 @entity10202 @entity1855 @entity1854 @entity9805 @entity26 @entity3360 @entity3988 @entity460 @entity594 @entity916 @entity4768 @entity1002
In @entity1 with @entity712 ( @entity712 ) due to @entity384 , @entity594 , @entity3988 and several of the newer @entity460 antagonists including @entity3360 , @entity9805 , @entity10202 and PN 200-110 ( @entity4768 ) improve left ventricular function. Because of its relatively more pronounced negative inotropic and chronotropic actions, @entity1855 is generally not tolerated by @entity1 with @entity1002 . In addition, even relatively vascular-selective agents such as @entity594 can occasionally cause significant @entity308 , particularly if combined with beta-adrenergic blocking agents. Comparative studies using @entity1854 to cause an equivalent decrease in arterial pressure indicate that @entity594 acts predominantly on the arterial vasculature, and that a small but significant decrease in contractility occurs, apparently due to a direct myocardial action. Although @entity3988 causes a @entity308 in @entity296 in @entity235 with volume overload @entity712 , limited data show no significant negative inotropic action in @entity1 with @entity712 . The negative inotropic effects, if any, of newer and possibly more vascular-selective agents are not yet known. @entity460 antagonists appear to act predominantly on the limb and coronary vasculature, with relatively less effect on renal and hepatic vessels. In @entity1 with @entity712 , @entity594 causes an increase in coronary blood flow and a decrease in the aorto-coronary sinus @entity26 difference indicating an improvement in myocardial energetics. Although @entity594 causes an increase in cardiac index and decreases in systemic vascular resistance and pulmonary capillary wedge pressure during exercise, the limited data available fail to show a short- or long-term increase in exercise capacity. @entity594 causes an increase in plasma @entity916 activity, possibly due to a direct action on the kidney.(ABSTRACT TRUNCATED AT 250 WORDS)
