Buccal adhesive nanofibers containing @entity1 growth hormone for XXXX .

@entity1 @entity3136 @entity5 @entity235 @entity1066 @entity33 @entity9105 @entity21049 @entity655 @entity1068
UNASSIGNED: Due to a lack of proper drug carriers to deliver treatments for @entity33 , many @entity5 @entity1 suffer from @entity3136 caused by chemotherapy and radiotherapy. We prepared a double-layered electrospun nanofibrous sheets composed of @entity21049 and chitosan to accelerate the healing rate of oral mucous @entity1066 . @entity1 growth hormone (hGH) and @entity21049 in a mixture of @entity9105 and @entity1068 were co-electrospun to nanofibrous sheets. The electrospun fibrous mat was subsequently layered with chitosan by a dip-coating method. @entity655 showed attenuated mass erosion while uncoated sheets were instantly melted at the physiological condition. The released hGH was trapped on the chitosan layer by the ionic interaction between positively charged chitosan and negatively charged hGH, and a large number of entrapped proteins remained on the SIS membrane due to the muco-adhesive properties of chitosan. hGH-incorporated sheets significantly increased proliferation of @entity1 dermal fibroblasts. In vivo study employing oral @entity1066 in @entity235 , the @entity1066 dressed with chitosan-layered sheets showed enhanced wound recovery and the chitosan layers on the sheet greatly assisted prolonged recovery. Therefore, chitosan-layered @entity21049 nanofibrous sheets can be potentially applied to developing muco-adhesive wound dressing materials with pH-dependent drug release by adjusting the thickness of chitosan sheath on the sheets.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.
