The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in XXXX .

@entity20154 @entity353 @entity28 @entity101 @entity19 @entity4807 @entity1017 @entity164 @entity1386
Intestinal chemosensory signaling pathways involving the gustatory G-protein, gustducin, and bitter taste receptors (TAS2R) have been implicated in gut hormone release. Alterations in gut hormone profiles may contribute to the success of bariatric surgery. This study investigated the involvement of the gustatory signaling pathway in the development of diet-induced @entity28 and the therapeutic potential of targeting TAS2Rs to induce body @entity353 . a-gustducin-deficient (a-gust-/-) @entity19 became less @entity28 than @entity164 ( @entity164 ) @entity19 when fed a high-fat diet (HFD). @entity1386 ( @entity1386 ) mass was lower in a-gust-/- @entity19 due to @entity101 as a result of increases in brown adipose tissue (BAT) thermogenic activity, involving increased protein expression of uncoupling protein 1. Intra-gastric treatment of @entity28 and a-gust-/- @entity19 with the bitter agonists @entity20154 (DB) or @entity4807 (Q) during 4 weeks resulted in an a-gustducin-dependent @entity1017 associated with a decrease in food intake (DB), but not involving major changes in gut peptide release. Both @entity1386 and 3T3-F442A pre-adipocytes express TAS2Rs. Treatment of pre-adipocytes with DB or Q decreased differentiation into mature adipocytes. In conclusion, interfering with the gustatory signaling pathway protects against the development of HFD-induced @entity28 presumably through promoting BAT activity. Intra-gastric bitter treatment inhibits @entity1017 , possibly by directly affecting adipocyte metabolism.
