Genetic variants in de novo lipogenic pathway genes predict the prognosis of surgically-treated XXXX .

@entity1 @entity71291 @entity59934 @entity5 @entity21713 @entity71292 @entity71293 @entity55069 @entity157 @entity204
UNASSIGNED: Over-expression of de novo lipogenesis (DNL) pathway genes is associated with the prognosis of various types of @entity5 . However, effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and @entity157 ( @entity157 ) @entity1 after surgery are still unknown. A total of 492 primary @entity157 @entity1 treated with surgery were included in this study. Nine SNPs in 3 genes ( @entity55069 , @entity21713 and @entity59934 ) of DNL pathway were genotyped. Multivariate Cox proportional hazard regression model and Kaplan-Meier curve were used to analyze the association of SNPs with clinical outcomes. Two SNPs in @entity55069 gene were significantly associated with overall survival of @entity157 @entity1 . @entity1 carrying homozygous variant genotype (VV) in @entity71291 had significantly increased risk of @entity204 , while @entity1 carrying VV genotype in @entity71292 had significant decreased risk of @entity204 , when compared with those carrying homozygous wild-type or heterozygous genotypes. Moreover, @entity1 carrying VV genotype in @entity71292 had decreased recurrence risk, while @entity1 carrying variant genotype in @entity71293 of @entity21713 gene had increased recurrence risk. Further cumulative effect analysis showed significant dose-dependent effects of unfavorable SNPs on both @entity204 and recurrence. SNPs in DNL genes may serve as independent prognostic markers for @entity157 @entity1 after surgery.
