Neurobehavioral effects of concurrent exposure to cesium-137 and paraquat during neonatal development in XXXX .

@entity1 @entity73 @entity148 @entity19
UNASSIGNED: As a result of nuclear power plants accidents such as Chernobyl or Fukushima, some @entity1 were exposed to external and internal ionizing radiation (IR). @entity1 brain is highly sensitive to IR during fetal and postnatal period when the molecular processes are not completely finished. Various studies have shown that exposure to low doses of IR causes a higher incidence of @entity73 . On the other hand, in industrialized countries, @entity1 are daily exposed to a number of toxicant pollutants. Exposure to environmental chemicals, such as paraquat (PQ), may potentiate the toxic effects induced by radiation on brain development. In this study, we evaluated the cognitive effects of concomitant exposure to low doses of internal radiation ((137)Cs) and PQ during neonatal brain development. At the postnatal day 10 (PND10), two groups of @entity19 (C57BL/6J) were exposed to (137)Cs (4000 and 8000Bq/kg) and/or PQ (7mg/kg). To investigate the spontaneous behavior, learning, memory capacities and @entity148 , behavioral tests were conducted in the offspring at two months of age. The results showed that cognitive functions were not significantly affected when (137)Cs or PQ were administered alone. However, alterations in the working memory and @entity148 were detected in @entity19 exposed to (137)Cs combined with PQ.
