Elevated Total XXXX Levels in Acute @entity385 Are Associated With Long-Term Mortality.

@entity1 @entity64 @entity6 @entity1255 @entity731 @entity204 @entity385
BACKGROUND AND PURPOSE: Total @entity1255 (tHcy) levels are associated with secondary vascular events and mortality after @entity64 . The aim of this study was to investigate whether tHcy levels in the acute phase of a @entity64 contribute to the recurrence of cerebro-cardiovascular events and mortality. METHODS: A total of 3799 @entity1 were recruited after hospital admission for acute @entity385 . Levels of tHcy were measured within 24 hours after primary admission. @entity1 were followed for a median of 48 months. RESULTS: During the follow-up period, 233 (6.1%) @entity1 died. After adjustment for age, smoking status, @entity6 , and other cardiovascular risk factors, @entity1 in the highest tHcy quartile (>18.6  mol/L) had a 1.61-fold increased risk of @entity204 (adjusted hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.03-2.53) compared with @entity1 in the lowest quartile ( <=10  mol/L). Further subgroup analysis showed that this correlation was only significant in the large-artery @entity731 @entity64 subtype (adjusted HR, 1.80; 95% CI, 1.05-3.07); this correlation was not significant in the small-vessel occlusion subtype (adjusted HR, 0.80; 95% CI, 0.30-2.12). The risk of @entity64 -related mortality was 2.27-fold higher for @entity1 in the third tHcy quartile (adjusted HR, 2.27; 95% CI, 1.06-4.86) and 2.15-fold more likely for @entity1 in the fourth quartile (adjusted HR, 2.15; 95% CI, 1.01-4.63) than for @entity1 in the lowest tHcy quartile. The risk of cardiovascular-related mortality and the risk of recurrent @entity385 were not associated with tHcy levels. CONCLUSIONS: Our findings suggest that elevated tHcy levels in the acute phase of an @entity385 can predict mortality, especially in @entity64 @entity1 with the large-vessel @entity731 subtype.
