Proinflammatory cytokine responses in @entity1 with XXXX .

@entity1 @entity650 @entity1569 @entity1356 @entity13236 @entity310 @entity5750 @entity4155 @entity4071 @entity272
UNASSIGNED: Background: Psoriasis is one of the most common, immune-mediated, chronic @entity272 . Proinflammatory cytokines play an important pathogenetic role at a local level. Objective: To assess whether the proinflammatory cytokines @entity1356 , @entity650 , @entity4155 , @entity13236 and @entity310 are released systemically during @entity1569 . Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from 30 @entity1 with @entity1569 and 30 healthy volunteers. Cytokine production was assessed in supernatants using an enzyme immunoassay after stimulation of PBMCs with microbial stimuli. In addition, flow cytometry was used to determine the subsets of monocytes involved and the intracellular @entity310 production in monocytes. Results: @entity4155 levels were significantly higher in the supernatants of PBMCs from psoriatic @entity1 after stimulation with phytohemagglutinin. @entity310 production was also significantly higher in cells from psoriatic @entity1 after stimulation with all stimuli, as compared with health volunteers. Similar changes were not found for the other cytokines. A statistically significant difference was observed between @entity1 and controls for inflammatory @entity5750 (+)/ @entity4071 (+) monocytes (p<0.0001) and patrolling @entity5750 -/ @entity4071 (+) monocytes. Conclusion: Hyper-production of @entity310 is documented in @entity1569 . These results support the concept that there is a systemic, proinflammatory component in @entity1569 .
