Karyotype analysis in XXXX ( @entity3052 ): comparison with ethnic group, age, morphology, and survival.

@entity1 @entity2008 @entity1778 @entity3052
The karyotype, @entity1778 cell morphology (FAB classification), ethnic group, age, sex, and survival were compared in 60 @entity1 with @entity3052 ( @entity3052 ), to determine their diagnostic and prognostic significance. An ethnic age difference was observed; a significantly greater number of black @entity1 were @entity1 . The majority of @entity1 were males. A higher frequency of @entity2008 was detected in @entity1 , yet they survived longer than adults. A specific, significant association between a (8; 21) karyotype and M2- @entity3052 was confirmed; four of ten @entity1 with M2- @entity3052 showed this translocation. The more mature morphology of M2- @entity3052 was associated with a longer survival irrespective of karyotype, ethnic group, and age. The specificity of t(15; 17) in M3- @entity3052 and nonrandom monosomy 7 in preleukemic @entity1 was confirmed. @entity1 , particularly adults, with normal karyotypes tended to survive longer than those with abnormal karyotypes. The @entity1 's age and the differentiative capacity of the leukemic cell appear to be as important as the karyotype in determining survival. The nonrandom association of certain chromosome aberrations in @entity3052 appears to be worldwide.
