Factors influencing the anti-inflammatory effect of XXXX therapy in @entity2506 .

@entity1 @entity3784 @entity39 @entity5 @entity310 @entity2506 @entity95 @entity6932 @entity693 @entity619 @entity1192 @entity880 @entity869
@entity619 ( @entity3784 ) interferes with the production of @entity5 @entity39 factor-alpha ( @entity310 ) and @entity1192 ) and can thereby diminish the secondary inflammatory response that follows initiation of antibacterial therapy. A beneficial effect on the outcome of @entity6932 in @entity1 has been proven, but until recently the effect of @entity3784 therapy in @entity2506 was uncertain. The aim of the present study was to evaluate factors that might influence the modulatory effect of @entity3784 on the antibiotic-induced inflammatory response in a @entity95 model of @entity2506 . @entity3784 (1 mg/kg) was given intravenously 30 min before or 1 h after administration of a pneumococcal cell wall extract, or the first dose of @entity869 . In @entity693 induced by cell wall extract, @entity3784 therapy prevented the increase in cerebrospinal fluid (CSF) leucocyte and @entity880 concentrations, but only if given 30 min before the cell wall extract. In @entity693 caused by live organisms, initiation of @entity869 therapy resulted in an increase in CSF @entity310 and @entity880 concentrations only in animals with initial CSF bacterial concentrations > or =5.6 log10 cfu/mL. In those animals, @entity3784 therapy prevented significant elevations in CSF @entity310 [median change -184 pg/mL, -114 pg/mL versus +683 pg/mL with @entity3784 (30 min before or 1 h after @entity869 ) versus controls (no @entity3784 ), respectively, P=0.02] and @entity880 concentrations [median change -10.6 mmol/L, -1.5 mmol/L versus +14.3 mmol/L with @entity3784 (30 min before or 1 h after @entity869 ) versus controls (no @entity3784 ), respectively, P=0.01]. These effects were independent of the timing of @entity3784 administration. In this model of @entity2506 , an antibiotic-induced secondary inflammatory response in the CSF was demonstrated only in animals with high initial CSF bacterial concentrations (> or =5.6 log10 cfu/mL). These effects were modulated by @entity3784 therapy whether it was given 30 min before or 1 h after the first dose of @entity869 .
