XXXX , @entity101 and @entity64 - does Alzheimer protect you?

@entity1 @entity64 @entity101 @entity6 @entity2204 @entity195 @entity65
OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of @entity195 ; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conducting an association study on 373 @entity1 with @entity195 and 286 unrelated control individuals. The occurrence and the age of onset of @entity6 and @entity65 were evaluated in both groups. @entity2204 genotype was analyzed in all subjects by PCR method. RESULTS: We report that, in Czech population carrying @entity2204 allele increases risk of @entity195 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between @entity2204 allele, @entity195 and @entity101 . @entity101 subjects with the @entity2204 allele have 1.5-fold greater risk of @entity195 . Thus, @entity101 together with @entity2204 allele translates into 1.5-fold higher risk of @entity195 . The most intriguing original finding in the present study is that @entity195 @entity1 have significantly later onset of @entity6 , @entity101 and @entity64 in comparison with control subjects. This effect was not influenced by @entity2204 genotype. The @entity6 appeared in @entity195 @entity1 on average more than 10 years later than in the control subjects (p<0.0001), @entity101 was diagnosed 14 years later in @entity195 @entity1 (p<0.00001) and @entity64 occurred on average 6 years later (p<0.005), compared to the control group. CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of @entity195 .
