Effects of XXXX on glycerolipid metabolism in cultured myoblasts.

@entity2366 @entity844 @entity5 @entity2434 @entity653 @entity8558 @entity1573 @entity865 @entity141 @entity864 @entity11396 @entity4357
We recently reported that treatment of differentiated @entity1573 embryo myoblasts in culture with the potent @entity5 promoter @entity864 ( @entity865 ) caused a 2-fold increase in the level of @entity11396 in the plasma membrane fraction within 15-30 min (Grove, R.I. and Schimmel, S.D. (1981) Biochem. Biophys. Res. Commun. 102, 158-164). This system has been characterized further and the metabolic origin and fate of the stimulated @entity2366 have been investigated. The stimulation of @entity11396 was insensitive to alterations of @entity141 concentration in the medium and to the presence of inhibitors of @entity141 flux, protein synthesis and prostaglandin synthesis. The @entity844 composition of the newly formed @entity2366 was similar to that of @entity2434 . In addition, the @entity653 moiety of the @entity2366 was shown to be derived from a lipid with metabolic turnover similar to that of @entity2434 . The @entity5 promoter was also found to stimulate rapidly synthesis of @entity8558 , @entity4357 and @entity2434 . A possible model is proposed, therefore, in which the @entity5 promoter stimulates a membrane-associated phospholipase C which generates @entity11396 via the hydrolysis of @entity2434 . The newly formed @entity2366 is then metabolized back to @entity2434 or to @entity8558 and @entity4357 .
