Altered microsatellites in incomplete-type @entity1944 adjacent to primary XXXX .

@entity1944 @entity5 @entity876 @entity1613 @entity105 @entity356
AIM: To investigate the presence of genetic instability in @entity1613 of the stomach. METHODS: Fifteen cases of @entity356 with a background of @entity1944 were studied by microsatellite assay at nine loci. Altered metaplastic mucosa was microdissected, reconstructed topographically, and examined immunohistochemically with an anti- @entity876 antibody, comparing its positive area with foci of microsatellite instability in each individual. RESULTS: Alterations at one or more loci were observed in seven of 15 @entity5 (46.7%) and four of 15 intestinal metaplasias (26.7%). Two cases of replication error positive phenotype had no microsatellite alterations in their metaplastic mucosa. All the microsatellite alterations in the metaplastic mucosa were @entity1944 around the respective @entity5 . Moreover, in one case, an identical pattern of microsatellite alteration was detected in the @entity5 tissue and in the adjacent metaplastic mucosa, suggesting the sequential development of @entity356 from @entity1944 . Frequent alteration was found at the locus D1S191 (1q), indicating that this locus might be altered early in the development of @entity356 . No significant association between microsatellite instability and @entity876 immunoreactivity was observed in the cases examined. CONCLUSION: These results indicate that microsatellite instability may be an early event in @entity105 , especially in @entity5 .
