Gender-specific aspects in primary and secondary prevention of XXXX .

@entity1 @entity712 @entity66 @entity1674 @entity3452 @entity1188 @entity583 @entity204 @entity65
Gender differences in biological substrates of disease determine different clinical manifestations of @entity66 with important implications for prevention, diagnosis and therapy in the two sexes. In @entity1 , the activity of sex hormones reduces the influence of CV risk factors during the reproductive age, and delays the onset of CHD of 2 decades compared to @entity1 . However, @entity1 as @entity1 suffer from CV events, and in @entity1 mortality from all CV causes and have greater than the sum of the others 7 causes of @entity204 together. @entity1 are more likely than @entity1 to die of a first @entity583 a probability of developing @entity712 or a second @entity1188 than their male counterparts. The levels of lipid components vary in different ages of life and in the two genders. TC and LDL increase in @entity1 between 35 and 50 years of age. On the contrary LDL levels do not change significantly in fertile @entity1 in which they have a lower predictive value for CHD than in @entity1 , HDL levels are higher in premenopausal @entity1 than in @entity1 of the same age and their role in predicting CHD is considerably higher in @entity1 . High @entity1674 and @entity3452 are more important as a risk factor in @entity1 than in @entity1 . Because of the greater incidence of @entity65 in @entity1 until the early 80s, the information about the importance of risk factors associated with an increased risk of @entity65 has been gathered mainly in @entity1 and transferred to @entity1 . Most studies on lipid-lowering therapy did not have the adequate statistical power to show significant reductions in CV events in @entity1 . Regarding the indications for use of statins in daily practice, current data suggest that in secondary prevention statins are equally effective in both genders while in primary prevention the CV benefits of lipid-lowering therapy in @entity1 are less clear than in @entity1 and therefore should be used according to the degree of risk calculated from the available score systems.
