Blood storage duration and biochemical recurrence of XXXX after radical prostatectomy.

@entity1 @entity263 @entity5
OBJECTIVE: To test the hypothesis that perioperative transfusion of allogeneic and autologous red blood cells (RBCs) stored for a prolonged period speeds biochemical recurrence of @entity263 after prostatectomy. @entity1 AND METHODS: We evaluated biochemical @entity263 recurrence in @entity1 who had undergone radical prostatectomy and perioperative blood transfusions from July 6, 1998, through December 27, 2007. Those who received allogeneic blood transfusions were assigned to nonoverlapping "younger," "middle," and "older" RBC storage duration groups. Those who received autologous RBC transfusions were analyzed using the maximum storage duration as the primary exposure. We evaluated the association between RBC storage duration and biochemical recurrence using multivariable Cox proportional hazards regression. RESULTS: A total of 405 @entity1 received allogeneic transfusions. At 5 years, the biochemical recurrence-free survival rate was 74%, 71%, and 76% for @entity1 who received younger, middle, and older RBCs, respectively; our Cox model indicated no significant differences in biochemical recurrence rates between the groups (P=.82; Wald test). Among @entity1 who received autologous transfusions (n=350), maximum RBC age was not significantly associated with biochemical @entity5 recurrence (P=.95). At 5 years, the biochemical recurrence-free survival rate was 85% and 81% for @entity1 who received younger and older than 21-day-old RBCs, respectively. CONCLUSION: In @entity1 undergoing radical prostatectomy who require RBC transfusion, recurrence risk does not appear to be independently associated with blood storage duration.
