Relevance of HPV Screening for Triaging Equivocal Cytology Findings in the @entity71073 -p, XXXX and Pap IIID Groups - Results of Two Long-Term Studies.

@entity1 @entity41784 @entity71073
UNASSIGNED: Introduction: The use of HPV screening for the triage of ASC-US (atypical squamous cells of undetermined significance) cytology results has been established as a sound standard by international trials whereas the data for other cytology findings are in part contradictory. There is a lack of long-term studies on the use of HPV triage in Germany. Materials and Methods: For the present study data from a primary HPV screening project involving @entity1 aged over 30 years, ongoing since 2006, and an epidemiological study on @entity1 aged between 20 and 27 years, ongoing since 2009, were used. Upon recruitment, all @entity1 underwent a smear test for cytology and screening for "high-risk" HPV using Hybrid Capture 2 (HC2). If both tests were positive or if there were persisting remarkable cytology findings or a positive HPV test, then clarification by colposcopy was performed. Results: Altogether, among 282 @entity1 with @entity71073 -p (ASC-US), @entity41784 (ASC-H) or Pap IIID (LSIL + CIN2) and negative HPV test there was no case of CIN3+. Among the @entity1 under 30 years of age, however, 69% (ASC-US) to 85% (LSIL + CIN2) of the remarkable findings were HPV positive, also among the older @entity1 with Pap IIID, the 71% prevalence of HPV was too high for a triage and even without triage there was a 23% risk for CIN3+. On the other hand, of the @entity1 over 30 years old with ASC-US ( @entity71073 -p) findings, only 21% were positive for HPV and the risk for CIN3+ in this group was high at 29%. Also for ASC-H ( @entity41784 ) findings in the age group of over 30 years with an HPV prevalence of 56% there was an efficient triage for CIN3+. Discussion: In summary, the HPV triage of ASC-US ( @entity71073 -p) findings in @entity1 aged over 30 years was found to be efficient; in contrast, LSIL + CIN2 (Pap IIID) findings in this age group justified an immediate referral to colposcopy whereas cytology control appeared to be sufficient for younger @entity1 .
