[Heart rate reduction using XXXX during coronary artery bypass grafting without cardiopulmonary bypass].

@entity1 @entity7202 @entity4560 @entity254 @entity460 @entity25097 @entity551
Coronary artery bypass grafting without the use of cardiopulmonary bypass (CPB) is performed with increasing frequency. Performing revascularization on a beating heart is technically more demanding than performing revascularization on the arrested heart, especially in high-risk @entity1 . beta-Blockers and @entity460 -channel antagonists have been used for the reduction of heart rate (HR) for the local immobilization of the anastomotic site. However, their negative inotropic actions often lead to serious @entity551 . Therefore, we investigated the effect of @entity4560 on HR reduction in high-risk @entity1 undergoing CABG without CPB. Ten high-risk @entity1 undergoing CABG without CPB were selected. To reduce HR during @entity254 , @entity4560 was administered during the procedure. Systemic blood pressure (sBP), HR, and cardiac index (CI) were measured from the induction of anesthesia to the end of surgery. All surgeries were successfully performed without serious complications. To keep the rate under 60 bpm, @entity4560 was administered at the time of @entity254 and this decreased the cardiac index from 2.19 to 1.95, while the @entity25097 was maintained easily over 90 mmHg with the infusion of @entity7202 . @entity4560 may be useful for the reduction of HR during coronary @entity254 in high-risk @entity1 undergoing CABG without CPB.
