Immunoexpression of growth factors and receptors in polymorphous low-grade XXXX .

@entity675 @entity6005 @entity6006 @entity5 @entity470 @entity540 @entity7991 @entity3 @entity7167 @entity420
BACKGROUND: Polymorphous low-grade @entity420 (PLGA) is a rare @entity5 that usually arises in the minor salivary glands. Growth factors are cell-secreted peptides that regulate biological processes such as growth, proliferation, and differentiation. In @entity5 , immunoexpression of growth factors and their receptors is associated with cell proliferation, @entity3 . This study analyzed the expression of growth factors and receptors in PLGA, in other to better understand the mechanisms involved in the process of neoplastic cell proliferation and @entity5 progression. METHODS: The expression of growth factors @entity540 , @entity6005 , @entity6006 and receptors @entity7167 , @entity7991 , @entity675 , and @entity470 was analyzed in 24 PLGA samples in comparison with normal salivary glands, by immunohistochemistry. A semi-quantitative analysis determined cell positivity in all stained sections. Scores were assigned according to percentage of reactive cells: score 0 < 10%; score 1-10 to 25%; score 2-25% to 50%; score 3->50%. The level of significance was set at 5%. RESULTS: Most of the growth factors and receptors, apart from @entity7991 , were significantly reactive in PLGA. Comparing to salivary acini, all of the reactive growth factors and receptors were significantly stronger in PLGA. Comparing to salivary ducts, the expression of @entity540 , @entity6006 , @entity7167 , and @entity470 was significantly stronger in the nuclei and/or cytoplasm of the neoplastic cells. CONCLUSIONS: The increased expression of the growth factors and receptors in the PLGA, compared to normal salivary glands, may be related to cell proliferation, somehow participating in the oncogenic process.
