@entity270 treatment in XXXX : a randomized study.

@entity1 @entity270 @entity28 @entity409 @entity493 @entity165
OBJECTIVE: A beneficial role of antioxidants in @entity28 individuals has hitherto been inferred only from uncontrolled pilot studies. The authors compared the effect of @entity270 and weight loss on transaminase values and on ultrasonographic bright liver in a controlled group of @entity1 with @entity28 -related @entity409 . METHODS: Twenty-eight @entity1 with @entity28 -related hypertransaminasemia and bright liver were randomly allocated to two single-blind groups: group 1 (n = 14) treated with a low-calorie diet associated with oral placebo for 5 months, and group 2 (n = 14) treated with a low-calorie diet associated with oral @entity270 (400 mg/d x 2 months, 100 mg/d x 3 months). Transaminase values and ultrasonographic liver brightness along with weight loss and @entity270 levels were monitored. RESULTS: Variations in transaminase levels and percentage of @entity1 with normalized transaminase values were comparable in the two groups. The disappearance of bright liver was observed only in @entity1 who lost weight and was twice as common in @entity1 from group 1. Two subgroups of @entity1 with complete normalization of transaminase values emerged as a consequence of controlled adherence to diet alone (n = 6; significant decrease of percent overweight: P = 0.0019 ) and to @entity270 alone (n = 7; unmodified percent overweight and significant increase of @entity270 / @entity165 ratio: P < 0.0001). Changes in treatment-induced @entity493 aminotransferase levels in these two subgroups were comparable at month 2, whereas values at month 5 were significantly lower in the subgroup adherent to diet alone (P = 0.04). In the subgroup adherent to @entity270 alone, after 2 months washout, transaminase remained stable in 5 @entity1 and increased in 2; bright liver persisted in all. CONCLUSIONS: Oral @entity270 warrants consideration in @entity28 -related @entity409 for @entity1 unable to adhere to low-calorie diets.
