Isometric handgrip exercise during @entity452 - @entity3897 stress echocardiography increases heart rate acceleration and decreases study duration and XXXX and @entity3897 dosage.

@entity1 @entity452 @entity63 @entity3897 @entity453
BACKGROUND: @entity452 - @entity3897 stress echocardiography (DASE) is an established test for the diagnosis and risk stratification of @entity1 with @entity453 . @entity3897 use to attain target heart rate prolongs test time. HYPOTHESIS: The aim of this study was to assess the utility of isometric handgrip exercise (33% maximal voluntary contraction x 4 min) with DASE. METHODS: We prospectively evaluated 131 @entity1 undergoing DASE randomized to handgrip exercise or no handgrip. Effect of handgrip exercise on endpoints: time to target heart rate (85% maximum predicted), recovery time, total test time, mean @entity452 and @entity3897 dosage, and the number of @entity63 responses were assessed. Effect of current beta-blocker medication use was also evaluated. RESULTS: Heart rate rose more quickly in the handgrip group. At 6-10 min (peak handgrip), mean heart rate rose 51 +/- 14 beats/min in the handgrip group compared with 38 +/- 18 beats/min in the no handgrip group (p < 0.0001). With handgrip, overall @entity452 study time was reduced by a mean of 4.3 min (16.4 +/- 6.9 vs. 20.7 +/- 8.4, p = 0.004) in all @entity1 , and by a mean of 5.9 min in @entity1 not on beta-blocker medication (p = 0.001). The handgrip group also had a lower mean dose of @entity452 (25.8 +/- 13.5 vs. 32.4 +/- 16.4 mg, p = 0.025). The mean @entity3897 dose was also lower (0.2 +/- 0.4 vs. 0.4 +/- 0.5 mg, p = 0.04). Handgrip exercise, however, did not decrease endpoints in @entity1 on beta-blocker medication. CONCLUSIONS: Use of isometric handgrip exercise with DASE decreases time to target heart rate, recovery time, overall study time, and mean dosage of @entity452 and @entity3897 . In @entity1 not on beta-blocker medication, handgrip exercise should be routinely incorporated into all DASE protocols.
