[Bone marrow mesenchymal stem cells suppress @entity526 -induced @entity1069 in XXXX ].

@entity32 @entity82 @entity1069 @entity4 @entity1505 @entity5116 @entity3426 @entity35 @entity526
OBJECTIVE: To investigate the inhibitory effect of bone marrow mesenchymal stem cells (BMSCs) on E coliinduced @entity1069 in @entity35 . METHODS: BMSCs were isolated, cultured and amplified by the attached choice method. Fifty SD @entity35 were randomized into five groups of equal number: normal control, @entity5116 ( @entity5116 ) , chronic @entity1069 (CBP), @entity5116 + BMSCs, and CBP + BMSCs, and the animals in the latter four groups were injected with @entity526 into both sides of the prostate under ultrasound guidance for 1 - 14 days to induce @entity5116 and for 4 - 12 weeks to induce CBP. The control @entity35 were injected with the same amount of PBS. Two weeks after injection of BMSCs into the prostates, pathomorphological changes in the prostate were observed under the light microscope and the mRNA and protein levels of @entity3426 and @entity1505 determined by RT-PCR and ELISA, respectively, followed by statistical analysis with SPSS 18.0. RESULTS: Histopathological evaluation showed typical pathological inflammatory changes in the prostates of the @entity35 in the @entity5116 and CBP groups, including glandular structural changes, interstitial @entity4 , @entity32 , and @entity82 , which were all remarkably relieved after treated with BMSCs. The mRNA and protein levels of IL-b ([0.829    0.121] and [271.75    90.59] pg/ml) and @entity1505 ([0.913    0. 094] and [105.78    19. 05] pg/ml) in the @entity5116 and those of @entity3426 ([0. 975    0. 114] and [265. 31    71. 34] pg/ml) and @entity1505 ([0. 886    0. 084] and [107. 45    26. 11 ] pg/ml) in the CBP groups were significantly higher than those in the control @entity35 ([0. 342    0.087] and [45.76 17. 99] pg/ml, P <0. 05); ([0.247    0.054] and ([19.42    7. 75] pg/ml, P <0. 01) as well as than those in the @entity5116 + BMSCs ([0. 433    0. 072] and [51. 34    22. 13] pg/ml, P < 0. 05 ) ; ( [0. 313    0. 076] and [28. 38    8. 78] pg/ml, P < 0. 01) and the CBP + BMSCs group ([0.396    0.064] and [56.37    21.22] pg/ml, P <0.05); ([0.417    0.068] and [29.21    10.22] pg/ml, P <0.01). CONCLUSION: Injection of BMSCs can reduce @entity526 -induced @entity1069 reaction, which.may be associated with its reduction of @entity32 and the expressions of @entity3426 and @entity1505 in the prostate tissue.
