Association of XXXX peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy.

@entity1 @entity5204 @entity2690 @entity2041 @entity1474 @entity413
@entity2041 peroxidase (GPx) is one of the most important antioxidant enzymes in @entity1 . We studied the relationship between erythrocyte GPx activity and fasting serum insulin, plasma @entity413 , and @entity2690 , estimates of insulin resistance from the homeostasis model of assessment as well as dietary fat intake in 408 normotensive nondiabetic pregnant @entity1 from Camden, NJ. GPx activity and the metabolic parameters were determined at entry to care (16 wk of pregnancy) and during the third trimester. GPx activity and the levels of insulin resistance increased significantly between entry and the third trimester. Statistically significant associations, all positive, were observed between GPx activity and fasting insulin (beta = 0.009, P < 0.001), @entity413 (beta = 0.975, P < 0.05), @entity2690 (beta = 1.537, P < 0.01), and insulin resistance from the homeostasis model of assessment (beta = 0.209, P < 0.01). Dietary intakes of fat and @entity1474 were positively correlated with GPx activity as well. African Americans had significantly higher GPx activity, dietary fat, and @entity5204 intake than Hispanics and Caucasians. In conclusion, we demonstrated that normal pregnancy is associated with increased GPx activity and insulin resistance. There are ethnic differences in antioxidant response and dietary fat intake. Our findings suggest a potential link among antioxidant defenses, insulin resistance, and dietary fat intake.
