4D flow MRI for intracranial hemodynamics assessment in XXXX .

@entity1 @entity16260 @entity73 @entity450 @entity195
UNASSIGNED: Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force for the perivascular/glymphatic clearance of beta-amyloid. Noninvasive cerebrovascular characteristic features that potentially assess these transport mechanisms are @entity450 ( @entity450 ) and pulsatility index (PI). In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly @entity450 , PI, resistive index (RI) and cross-sectional area in @entity1 with @entity195 ( @entity195 ), mild @entity73 and in age matched and younger cognitively healthy controls. Three-hundred fourteen subjects participated in this study. Volumetric, time-resolved phase contrast (PC) MRI data were used to quantify hemodynamic parameters from 11 vessel segments. Anatomical variants of the @entity16260 were also cataloged. The @entity195 population reported a statistically significant decrease in @entity450 and cross-sectional area, and also an increase in PI and RI compared to age matched cognitively healthy control subjects. The 4D flow MRI technique used in this study provides quantitative measurements of intracranial vessel geometry and the velocity of flow. Cerebrovascular characteristics features of vascular health such as pulsatility index can be extracted from the 4D flow MRI data.
