Physical Activity Level and Future Risk of Mild XXXX or @entity303 : A Critically Appraised Topic.

@entity1 @entity303 @entity73 @entity179 @entity195
BACKGROUND:: The relationships between physical activity, cognition, and development of @entity179 represent an area of intense research interest. Meta-analyses and prospective cohort studies show that greater levels of physical activity are associated with lower @entity303 risk. Most studies, however, depend on self-report data that are subject to recall and other biases. Obtaining objective and quantitative physical activity data could strengthen observational study validity. OBJECTIVE:: To examine the association between objectively measured daytime activity and @entity73 ( @entity73 ) or @entity195 ( @entity195 ). METHODS:: The objective was addressed through the development of a structured, critically appraised topic. We incorporated a clinical scenario, background information, a structured question, literature search strategy, critical appraisal, results, evidence summary, commentary, and bottom line conclusions. @entity1 included consultant and resident neurologists, clinical epidemiologists, a medical librarian, and behavioral neurology and neuropsychiatry content experts. RESULTS:: We selected a prospective, single-center cohort study of 716 cognitively normal elderly @entity1 followed for 3.5 years. Greater levels of physical activity, as measured using wrist actigraphy, were associated with a lower risk of incident @entity73 or @entity195 (hazard ratio, 0.477; 95% confidence interval, 0.273-0.832). CONCLUSIONS:: Objective measurement confirms that greater levels of physical activity are associated with decreased risk of a future diagnosis of @entity73 or @entity195 . Further studies are needed to confirm the temporal association of exercise and future cognitive health and understand the relevant underlying biological mechanisms.
