Experimental acute lead encephalopathy in the juvenile XXXX .

@entity410 @entity10108 @entity4 @entity346 @entity2608 @entity8454 @entity2055 @entity560
Lead subacetate (0.5g) and 1000 units of @entity560 were given three times a week to four newly-weaned @entity2608 . In addition, two animals received only the @entity560 . The poisoned animals had an increase in the urinary excretion of @entity8454 , an elevated content of lead in the blood, and a fall in hemoglobin concentration. Between 6 and 18 weeks the animals suddenly developed @entity2055 , @entity346 , generalized weakness, and @entity410 . At this time the animals were killed by perfusion of fixative and the brain prepared for light and electron microscopic studies. Definite morphological evidence of disease was confined to the central nervous system, except for one animal which showed the characteristic renal inclusions of @entity10108 . All animals showed PAS-positive globules associated with blood vessels and an exudative @entity4 involving the white matter of the cerebral hemispheres and cerebellum. Ultra-structurally, this appeared as a granular precipitate within an expanded extracellular space. Alterations of nerve fibers were not seen in the white matter but axonal swelling was observed in the cerebral cortex. The perikaryon and neuropil appeared normal. The control animals showed no significant cerebral changes.
