Effect of local inhibition of XXXX synthesis on forearm blood flow and dorsal hand vein size in @entity1 with @entity7160 .

@entity1 @entity82 @entity7293 @entity842 @entity432 @entity1063 @entity7160
1. @entity842 (NO) is a potent endogenous vasodilator and plays a role in the control of resting vascular tone. @entity1 with @entity82 have a hyperdynamic circulation with reduced blood pressure and decreased peripheral resistance, and it is possible that increased production of NO due to induction of NO synthase may be involved in maintaining this vasodilatation. We have examined this possibility by studying the effects of local infusions of @entity7293 (an inhibitor of NO synthase) in the forearm arteriolar bed and the superficial dorsal hand veins of @entity1 with @entity7160 . 2. Drugs were either infused locally into the brachial artery and forearm blood flow was measured by @entity432 plethysmography, or into a vein on the back of the hand and vein diameter was measured using a linear displacement technique. 3. Basal forearm blood flow was increased and vascular resistance was decreased in the @entity1 with @entity7160 compared with healthy control subjects. @entity1063 and @entity7293 caused dose-dependent falls in forearm blood flow in both healthy control subjects and @entity1 with @entity82 . There was no significant difference in the responses to either @entity1063 or @entity7293 between the two groups. 4. In the superficial hand veins there was no change in vein size in response to @entity7293 infused alone, and venoconstriction to local infusion of @entity1063 was unaffected by co-infusion with @entity7293 . 5. Our results confirm that @entity1 with @entity7160 are vasodilated compared with healthy control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
