XXXX iontophoresis for local anesthesia before shave biopsy.

@entity1 @entity3303 @entity158 @entity272 @entity110
BACKGROUND: @entity3303 iontophoresis is a method of topical anesthesia in which @entity3303 is driven into the skin under the influence of electric current. OBJECTIVE: To compare @entity3303 iontophoresis to placebo for topical anesthesia before shave biopsy in adult @entity1 . METHODS: This was a single-center, double-blind, placebo-controlled evaluation of iontophoresis of 2% @entity3303 with 1:100,000 epinephrine in @entity1 undergoing shave biopsy. @entity1 were evaluated for sensation to pinprick after iontophoresis. After completion of the procedure, those @entity1 who did not receive supplemental @entity3303 rated the @entity158 associated with the procedure using a 10-cm visual analog scale. The investigator also evaluated the @entity1 's @entity158 after biopsy. Treatment sites were examined for evidence of adverse events such as erythema, @entity110 , or burns. RESULTS: Forty-one @entity1 undergoing shave biopsy for evaluation of @entity272 were enrolled. Nineteen of 21 @entity1 in the @entity3303 group versus 2 of 20 placebo @entity1 required no supplemental anesthesia (P<0.001). The @entity158 reported by the @entity1 on the visual analog scale subsequent to the procedure was significantly lower in the @entity3303 group (P<0.001). In concordance with the results reported by the @entity1 , investigators rated @entity158 lower in the @entity3303 group (P<0.001). Blanching and/or erythema occurring at the iontophoresis-treated site in 37 of 41 @entity1 resolved within 1 hour. There were no other treatment-related events. CONCLUSIONS: @entity3303 iontophoresis is a safe and effective method of administering topical anesthesia before shave biopsy in adult @entity1 .
