Peripheral XXXX , an uncommon clinical onset of @entity5 . Case report and review of the literature.

@entity1 @entity548 @entity706 @entity5 @entity16 @entity10469 @entity1583 @entity151 @entity694
A case of a 76-year-old @entity1 presenting with weakness of the lower legs and bilateral steppage gait is described. Neurological examination revealed a @entity16 with axonopathy and myelinic aspects. At the time of the diagnostic workup an episode of @entity548 occurred. Colonoscopy demonstrated an exophytic @entity694 at 40 cm from the anal verge. At surgery the @entity5 adhered to the ileum, so a left hemicolectomy and ileo-ileal resection were performed. @entity5 stage was Dukes' B, Jass III, Astler-Coller B2, T3N0M0. The @entity1 underwent postoperative chemotherapy and was followed for the past three years. At present he is free of @entity16 has completely regressed without any dedicated therapy. As reported in the literature the appearance of a @entity16 ( @entity16 ) may be the first sign of a @entity5 that is occult at the time of clinical presentation. The most widely supported theory about its etiology is that of an autoimmune origin. The @entity16 is considered to be at a point of intersection between @entity5 immunology, @entity10469 , and basic neurobiology. Previous experience has resulted in a pathogenic model and in a definition of a group of autoantibodies related to the disease. @entity151 ( @entity151 ) is the @entity5 most frequently associated with @entity16 ; other @entity706 and various @entity1583 . Some authors reported also that the percentage of @entity1 with a high titer of neuronal autoantibodies is small and several of the autoantibodies are present at low levels without any accompanying clinical manifestation. In a clinical retrospective study of the Mayo Clinic Group 115,081 @entity1 were examined over the period 1984-1993 and only 58 @entity1 (0.05%) could be defined as being affected by a @entity16 . Only five of these @entity1 had @entity694 . The number of @entity1 is so small and so widely scattered among publications that no statistical analysis is possible. Probably the only possibility for early identification of such a syndrome is a high degree of suspicion. In fact, these @entity1 are usually first admitted and studied in a neurological unit, and the diagnosis of a @entity5 is a delayed event.
