Modulatory effect of brain XXXX on reflex-induced @entity1168 and @entity591 in conscious @entity35 .

@entity35 @entity1854 @entity6959 @entity591 @entity3897 @entity299 @entity2607 @entity11348 @entity1063 @entity1168 @entity934
The effects of intracerebroventricular (i.c.v.) injection of @entity2607 and @entity11348 (HC-3) on reflex @entity1168 and @entity591 have been studied in unanesthetized @entity35 . The reflex increases and decreases in @entity299 were elicited by i.v. injection of @entity1063 and @entity1854 , respectively. @entity2607 (5-10 micrograms) increased basal mean arterial pressure (MAP), reduced basal @entity299 ( @entity299 ), enhanced the reflex @entity1168 and reduced reflex @entity591 . @entity2607 did not modify either the pressor effect of @entity1063 , the depressor effect of @entity1854 or the responsiveness of peripheral muscarinic receptors. Pretreatment (i.c.v.) with @entity3897 (0.3 micrograms) completely abolished the effect of @entity2607 on MAP, @entity299 , reflex @entity1168 and reflex @entity591 . Pretreatment (i.c.v.) with @entity6959 (50 micrograms) did not modify the effect of the cholinesterase inhibitor on MAP, @entity299 and reflex @entity591 , but inverted its effect on reflex @entity1168 . Injection of HC-3 (20 micrograms i.c.v.) did not modify MAP, but reduced @entity299 and inhibited both reflex @entity1168 and reflex @entity591 . The HC-3 bradycardic effect started within minutes and lasted for about 1 hr, while the depressor effect on the reflexes began only after 15 min and continued for several hours. In addition, i.c.v. pretreatment with HC-3 completely abolished all the effects of @entity2607 on MAP, @entity299 , reflex @entity1168 and reflex @entity591 . These results suggest that brain @entity934 has a modulatory effect on baroreceptor reflexes. This modulation operates through muscarinic receptors in reflex @entity591 and through both muscarinic and nicotinic receptors in reflex @entity1168 .
