XXXX increases urinary albumin and alpha-1 microglobulin excretion in @entity6 .

@entity1011 @entity3876 @entity6 @entity8224
@entity8224 ( @entity8224 ) increases urinary albumin excretion in @entity6 ( @entity6 ). @entity3876 ( @entity3876 ) is structurally and functionally related to @entity8224 , but its effect on urine albumin excretion rate (UAER) is unknown. AIMS: To compare the albuminuric effects of intravenous infusion of @entity8224 and @entity3876 , and to assess the effect of both peptides on tubular protein excretion. METHODS: Eight subjects with Type 1 @entity6 were randomised to a three leg, double blind, and placebo controlled study. On each study day, subjects were euglycaemic clamped and subsequently water loaded (20 mL/kg orally, plus urine losses) to steady state diuresis. When in steady state, @entity1011 clearance was estimated in three separate 1 hour periods. At the end of the first period, a 1 hour intravenous infusion of either placebo, @entity8224 0.025 microg/kg/min, or @entity3876 0.025 microg/kg/min was administered. There followed a 1 hour recovery period. Urine was collected at 15 min intervals for estimation of urine albumin (ACR) and alpha1 microglobulin @entity1011 ratio (MCR). Results were analysed by anova. RESULTS: @entity1011 clearance was similar on the three study days, and was unaltered by any infusion. ACR was unaltered by placebo (1.3 +/- 0.5-1.2 +/- 0.4 mg/mmol, mean +/- SD, p = 0.81), but increased compared to placebo with infusion of both @entity8224 (1.2 +/- 0.4-9.8 +/- 8.4 mg/mmol, P = 0.0004), and @entity3876 (1.1 +/- 0.4-13.4 +/- 8.6 mg/mmol, P = 0.0001). The MCR was unaltered by placebo infusion (P = 0.89), but increased compared with placebo after infusion of @entity8224 (5.4 +/- 0.9-12.3 +/- 4.2 mg/mmol, P < 0.0001), and @entity3876 (5.4 +/- 0.8-12.1 +/- 2.5 mg/mmol, P < 0.0001). CONCLUSIONS: Intravenous infusion of @entity3876 and @entity8224 both increase the urine excretion of albumin and the tubular protein alpha1 microglobulin, independent of @entity1011 clearance.
