Ligation of Intersphincteric Fistula Tract vs Ligation of the Intersphincteric Fistula Tract Plus a Bioprosthetic Anal Fistula Plug Procedure in XXXX With @entity9292 : Early Results of a Multicenter Prospective Randomized Trial.

@entity1 @entity322 @entity31084 @entity9292 @entity282
OBJECTIVE: The purpose of this study was to compare the @entity31084 ( @entity31084 ) with an additional plug ( @entity31084 -plug) in the treatment of @entity9292 . SUMMARY BACKGROUND DATA: Both @entity31084 and @entity31084 -plug are recently reported effective alternatives of @entity9292 . METHODS: This multicenter prospective randomized study (NCT01478139) was conducted at 5 university hospitals throughout China. A total of 235 @entity1 were randomly assigned to undergo @entity31084 (118 @entity1 ) or @entity31084 -plug (117 @entity1 ) between March 2011 and April 2013. The primary outcome measured was primary healing rate at 6 months postoperatively and healing time. Secondary outcomes included recurrence rate, @entity282 , and @entity322 rate. RESULTS: The @entity31084 procedure showed shorter operative time than the @entity31084 -plug procedure (26.7min vs 28.5min, P=0.03). Median healing time was 22 days in @entity31084 -plug group vs 30 days in @entity31084 group (P<0.001). The difference in visual analog scale scores across all time points was not statistically significant between the groups (P=0.13). The primary healing rate was higher in @entity31084 -plug group than in @entity31084 group [94.0% (95% confidence interval 89.7%-98.3%) vs 83.9% (95% confidence interval 77.2%-90.6%), P<0.001]. There were no reported @entity322 and recurrence within the follow-up period of 6 months. CONCLUSIONS: In @entity1 with @entity9292 , both @entity31084 -plug and @entity31084 are simple, safe, and effective procedures. @entity31084 -plug has the advantage of a higher healing rate, less healing time, and a lower early @entity282 score.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0.
