Calorie restriction modifies @entity12931 and COQ transcript levels in XXXX tissues.

@entity51171 @entity12931 @entity19 @entity72674 @entity70448 @entity72676 @entity72675
We studied @entity12931 (Q), Q homologue ratio, and steady-state levels of mCOQ transcripts in tissues from @entity19 fed ad libitum or under calorie restriction. Maximum @entity12931 levels on a protein basis were found in kidney and heart, followed by liver, brain, and skeletal muscle. Liver and skeletal muscle showed the highest Q(9)/Q(10) ratios with significant interindividual variability. Heart, kidney, and particularly brain exhibited lower Q(9)/Q(10) ratios and interindividual variability. In skeletal muscle and heart, the most abundant mCOQ transcript was @entity51171 , followed by mCOQ8, @entity72674 , @entity72675 , @entity70448 , and @entity72676 . In nonmuscular tissues (liver, kidney, and brain) the most abundant mCOQ transcript was @entity72674 , followed by @entity51171 , mCOQ8, @entity70448 , @entity72675 , and @entity72676 . Calorie restriction increased both @entity12931 homologues and @entity72675 mRNA in skeletal muscle, but @entity51171 was decreased. In contrast, Q(9) and most mCOQ transcripts were decreased in heart. Calorie restriction also modified the Q(9)/Q(10) ratio, which was increased in kidney and decreased in heart without alterations in @entity70448 or @entity72675 transcripts. We demonstrate for the first time that unique patterns of mCOQ transcripts exist in muscular and nonmuscular tissues and that Q and COQ genes are targets of calorie restriction in a tissue-specific way.
