Search for an Endogenous Bombesin-Like Receptor 3 ( XXXX -3) Ligand Using Parabiotic @entity19 .

@entity28 @entity19 @entity4375 @entity164 @entity72514
UNASSIGNED: Bombesin-like receptor 3 ( @entity4375 -3) is an X-linked G protein-coupled receptor involved in the regulation of energy homeostasis. @entity72514 null ( @entity72514 -/y) @entity19 become @entity28 . To date, no high affinity endogenous ligand has been identified. In an effort to detect a circulating endogenous @entity4375 -3 ligand, we generated parabiotic pairs of @entity19 between @entity72514 -/y and @entity164 ( @entity164 ) @entity19 or between @entity164 controls. Successful parabiosis was demonstrated by circulatory dye exchange. The @entity72514 -/y- @entity164 and @entity164 lost similar weight immediately after surgery. After 9 weeks on a high fat diet, the @entity72514 -/y- @entity164 pairs weighed more than the @entity164 . Within the @entity72514 -/y- @entity164 pairs, the @entity72514 -/y @entity19 had greater adiposity than the @entity164 @entity19 , but comparable lean and liver weights. Compared to @entity164 @entity19 in @entity164 , @entity72514 -/y and @entity164 @entity19 in @entity72514 -/y- @entity164 pairs each had greater lean mass, and the @entity72514 -/y @entity19 also had greater adiposity. These results contrast to those reported for parabiotic pairs of leptin receptor null (Leprdb/db) and @entity164 @entity19 , where high leptin levels in the Leprdb/db @entity19 cause the @entity164 parabiotic partners to lose weight. Our data demonstrate that a circulating endogenous @entity4375 -3 ligand, if present, is not sufficient to reduce adiposity in parabiotic partners of @entity72514 -/y @entity19 .
