Lymphocytic Infiltration as a Prognostic Factor in XXXX With Colon Cancer.

@entity1 @entity2617 @entity5 @entity2225 @entity14
UNASSIGNED: Host-defense mechanisms may have an important role in predicting the outcome of @entity14 @entity1 . We designed our study to evaluate the possible prognostic significance of the presence of @entity2617 ( @entity2617 ) and subgroups of lymphocytes (CD3 and @entity2225 ) in the @entity5 . We randomly selected 195 @entity1 operated for @entity14 from a larger cohort of 1527 @entity1 with @entity14 . Histological slides were blindly reevaluated for the presence of @entity2617 that was graded 0 to 3. Immunohistochemical phenotyping of the lymphocytes was performed only for @entity5 with @entity2617 score 3 and included antibodies CD3 and @entity2225 . CD3 and @entity2225 immunostaining were graded in the same manner as @entity2617 . The mean duration of follow-up was 63.8 months. The distribution of @entity1 with @entity14 according to @entity2617 scores was as follows: score 0, 20/195 (10.2%); score 1, 61/195 (31.3%); score 2, 78/195 (40%); and score 3, 36/195 (18.5%). There was no correlation between any clinicopathological pattern and @entity2617 . Score 3 staining for CD3 was more common than for @entity2225 (64.7% vs 8.8%, P < .0001). @entity2617 (score 3) was associated with better disease-free survival (P = .062). Recurrence was diagnosed among 2/22 (9.1%) @entity1 with prominent CD3 staining versus 62/171 (36.2%) of all other @entity1 groups (P = .054) and they correspondingly had better disease-free survival (P = .018). It seems we can identify a group of @entity1 with @entity14 who have an excellent prognosis according to a single immunological test unrelated to other known prognostic factors.
