Anthropometric factors, adult XXXX , and mammographic features.

@entity1 @entity1017
PURPOSE: To evaluate the association between anthropometric factors, @entity1017 during adulthood, and mammographic features among 1,435 @entity1 recruited at screening mammography. METHODS: Spearman's partial coefficients were used to evaluate the correlation of anthropometric factors with mammographic features (percent density, absolute dense area, and non-dense area). Multivariate generalized linear models were used to evaluate the associations between weight change categories and mammographic features. RESULTS: Body mass index was inversely correlated with percent density (r  =  -0.49, p  <  0.0001) or absolute dense area (r  =  -0.21, p  <  0.0001) and positively correlated with absolute non-dense area (r  =  0.69, p  <  0.0001). However, body mass index was positively correlated with absolute dense area when adjusting for absolute non-dense area (r  =  0.16, p  <  0.0001). Similar results were observed for weight, waist circumference, and waist-to-hip ratio with mammographic features. Within increasing categories of weight change, percent density (p trend  <  0.0001) and absolute dense area (p trend  =  0.025) increased, while absolute non-dense area decreased (p trend  <  0.0001). After stratification by the median of non-dense area, the positive association between @entity1017 and absolute dense area remained only among @entity1 with higher non-dense area. CONCLUSIONS: Adiposity seems positively associated with both dense and non-dense areas following adjustment for each other. Our findings suggest a higher breast dense area among @entity1 who gained weight and that a minimum of breast fat may be needed to promote the proliferation of this fibroglandular tissue.
