Concentrations of penicillin, streptomycin, and @entity7912 in XXXX udder tissue liquids.

@entity691 @entity16630 @entity14287 @entity7912 @entity3397 @entity291
Concentrations of @entity3397 and @entity7912 adipate were determined in @entity291 plasma and milk and in lymph draining the udder tissue after IM or IV administration. Combined @entity3397 and @entity14287 concentrations were also determined in the same fluids after intramammary injection. A superficial parenchymal lymph vessel, afferent to the supramammary lymph gland of the left quarters, was cannulated with a @entity691 catheter from which the lymph was allowed to drain freely. After injections of 9.5 mg of @entity3397 /kg of body weight IM, a mean peak concentration (PC) in lymph (3.7 micrograms/ml), constituting 77% of the PC in plasma (4.8 micrograms/ml), was obtained 0.5 to 1 hour after PC in the plasma. The @entity3397 lymph concentration was close to that in plasma for about 7 hours after injection. Thereafter, the @entity3397 lymph concentration continued to exceed that in plasma, but not that in milk. After IV administration of @entity7912 adipate, the lymph concentration was almost identical to that in plasma. After intramammary injection of @entity16630 (400 mg), in combination with the same amount of @entity14287 , into 2 udder quarters each, mean PC in the lymph of 3.5 micrograms/ml and 8.4 micrograms/ml, respectively, were obtained 6 hours after injection. In plasma, the mean PC of @entity3397 (0.07 micrograms/ml) and of @entity14287 (0.85 micrograms/ml) were obtained after 4 and 6 hours, respectively. In milk from the nontreated quarters, a mean concentration of 5 ng of @entity3397 /ml was obtained, whereas @entity14287 (greater than or equal to 0.3 microgram/ml) was not detected.(ABSTRACT TRUNCATED AT 250 WORDS)
