XXXX in @entity1582 : the impact of selection criteria on outcome.

@entity1 @entity8 @entity2783 @entity1582 @entity10543 @entity1985 @entity551
@entity8 ( @entity8 ) for @entity1582 ( @entity2783 ) produces high hematologic and organ responses. However, treatment-related mortality remains high and reported series are subject to selection bias. In all, 48 of 80 @entity10543 @entity1 referred to our center had @entity2783 in the absence of @entity1582 , 26 of these 48 were deemed transplant candidates and 20 actually underwent @entity8 . Transplant-related mortality has fallen from 50 to 20% since January 1999 due to better @entity1 selection and prophylactic measures. Intent-to-treat organ responses were renal (46%), cardiac (25%) and liver (50%). Organ responses in @entity1 who survived transplantation were renal (75%), cardiac (40%) and liver (100%). The 3-year OS post- @entity8 was 56% with improved outcome predicted by a better performance status (P=0.08), normal ALP (P=0.08), @entity1985 (P=0.01) and the absence of severe @entity551 (P=0.01). The 3-year OS for all referred @entity1 was 44% and this was not significantly better for transplant candidates. @entity1 with significant @entity551 (systolic blood pressure < or =90 mmHg) or poor performance status (ECOG >2) have an exceedingly high treatment-related mortality and should not be transplanted. For those undergoing @entity8 , organ response rates appear promising, but conclusive evidence of improved survival for this select group of @entity1 is still lacking and will require randomized trials.
