XXXX during PBPC apheresis in an unrelated donor.

@entity1 @entity1261 @entity907 @entity299 @entity2280 @entity1167
BACKGROUND: Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu @entity1261 and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS: We report a severe complication in a 41-year-old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 microg of @entity1261 per kg per day. During PBPC apheresis, she experienced a @entity1167 after 132 minutes and processing of 7078 mL of blood (twice the donor's blood volume). RESULTS: Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a @entity907 . Other @entity299 could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4-year-old recipient was successfully transplanted with the partial product collected until the arrest occurred. The @entity1 received a total of 2.54 x 106 @entity2280 + cells per kg of body weight. CONCLUSION: After exclusion of other @entity299 , the diagnosed @entity907 probably induced the @entity1167 during apheresis rather than the administration of @entity1261 .
