The functional neuroanatomy of XXXX subsyndromes.

@entity1 @entity161
BACKGROUND: There is considerable variability between @entity1 in their expression of the diverse range of symptoms encompassed by the syndrome of @entity161 , which may modulate functional activation to cognitive processing. METHOD: Here we investigate associations between @entity161 subsyndrome scores, identified by factor analysis, and experimentally controlled brain activation. Five factors were defined by rotated principal components analysis of PANSS rating scale measurements in 100 @entity1 with @entity161 . A subsample of 30 @entity1 and a group of 27 comparison subjects were studied using functional magnetic resonance imaging (fMRI) during the performance of two periodically designed cognitive activation experiments: verbal working memory and psychomotor sequencing. RESULTS: Factor analysis replicated the five dimensions consistently reported. Within the @entity1 group. power of activation by working memory was negatively associated with global symptom severity in left lingual and temporo-parietal cortices; negatively associated with positive subsyndrome scores in left inferior frontal and superior temporal cortices and basal ganglia; and positively associated with negative subsyndrome scores in lateral and medial premotor cortex. No relationship was observed between subsyndrome scores and functional activation during the motor task. Between-group comparisons demonstrated reduced power of response to the working memory task by @entity1 in bilateral dorsolateral prefrontal and left pre- and post-central cortices. CONCLUSIONS: In this study we observed task-specific modulation of functional response associated with symptom expression in @entity161 . Our findings are compatible with previous empirical findings and theoretical conceptualization of @entity1 brain function, in terms of capacity constraints on activation in the face of competing demands from pathological and task-related cognitive activity.
