Effect of @entity561 on early XXXX .

@entity1 @entity8 @entity174 @entity1133 @entity604 @entity170 @entity561 @entity5886 @entity1555 @entity2331 @entity1391 @entity460 @entity1011 @entity560
INTRODUCTION: Renal transplant recipients (RTRs) are at risk of developing @entity170 and @entity2331 due to underlying @entity8 , @entity5886 , and immunosuppression. This process occurs more frequently in the first year after renal transplantation (RTX), resulting in eventual @entity604 and @entity174 . The purpose of this study was to evaluate the effect of low-dose @entity561 to prevent early @entity604 after RTX. @entity1 AND METHODS: We prospectively studied 43 successful RTR including 22 @entity1 and 21- @entity1 with a mean overall age of 39.16  11.73 years, mean body mass index of 23.6  3.73, and mean dialysis duration of 25.73  17.67 months. We matched them based on age and sex: the @entity561 -treated group received @entity560 (Vit D) during the study plus 30 mg @entity561 weekly from 1 month after RTX. The control group only received Vit D. We measured serum @entity460 , @entity1391 , alkaline phosphatase, blood @entity1133 , @entity1011 , and intact parathyroid hormone (iPTH) at the pretransplant baseline and monthly thereafter as well as @entity1555 of the lumbar spine, femur, and radius pretransplant baseline versus 3 and 6 months after RTX. RESULTS: At 6 month after RTX, the lumbar @entity1555 in the @entity561 group increased significantly from 0.819  0.11 to 0.863  0.14 (P<.01), while it decreased in the control group from 0.897  0.17 to 0.817  0.16 (P<.001). There was also a significant increase in radius @entity1555 (P<.001) and a nonsignificant increase in femoral @entity1555 in the @entity561 versus a significant decrease of femoral and radius @entity1555 (P<.001) in the control group at 6 months. Upon multivariate analysis, there was a significant correlation between @entity561 and spine @entity1555 (r=.45, P<.001) but no linear regression between age, sex, BMI, dialysis duration of or iPTH with femoral, spine, or radius @entity1555 changes at month 6. CONCLUSION: Low-dose @entity561 was significantly useful to mitigate fast @entity604 and increase @entity1555 immediately after RTX.
