Potentiation of @entity1499 -induced XXXX by non-steroidal anti-inflammatory drugs (NSAIDs) and @entity1891 .

@entity1501 @entity1 @entity353 @entity2697 @entity19 @entity11141 @entity344 @entity9109 @entity1891 @entity1500 @entity880 @entity11464 @entity1499 @entity413 @entity20660
Inhibition of intestinal nutrient absorption by the @entity1501 antagonist @entity1499 ( @entity1500 ) and the effects of several organic acid drugs and @entity1891 on @entity1500 -induced @entity344 were investigated. Male Swiss-Webster @entity19 received @entity1500 , 25 mg/kg, i.p. once daily for 4 successive days. Using the everted sac technique, the rates of @entity413 and @entity9109 transport were decreased by @entity1500 to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively. @entity20660 , @entity11141 , @entity11464 , or @entity1891 administered simultaneously with @entity1500 , further decreased the rates of @entity413 transport to 3.6, 2.0, 0.8, and 2.6 mumol/g/h, respectively, and the rates of @entity9109 transport to 1.2, 1.9, 0.6 and 0.9 mumol/g/h, respectively. When intestinal sacs from untreated animals were exposed to @entity1500 (10(-3) M) on the serosal side only, the drug had no significant effect on the rate of transport of @entity413 or @entity9109 . The rate of @entity880 production in everted intestinal sacs from @entity1500 treated animals decreased to 11.8 from a control value of 30.3 mumol/g/h. Co-administration of @entity11464 with @entity1500 further decreased the rate of @entity880 production to 8.2 mumol/g/h. Body @entity353 caused by @entity1500 treatment (15.0%) was potentiated by the concurrent administration of probenecid (19.4%), @entity2697 (22.4%), @entity11464 (23.0%) or @entity1891 (22.8%). These results demonstrate that @entity1891 and several commonly used organic acid drugs can potentiate the inhibitory effect of @entity1500 on intestinal nutrient absorption. Thus, @entity1500 dosage adjustment may be required in @entity1 receiving such drugs.
