Neurobiological changes by cytotoxic agents in XXXX .

@entity632 @entity32 @entity19 @entity73 @entity786 @entity2359 @entity34736 @entity20446 @entity1499 @entity678 @entity1205 @entity1945 @entity1487
UNASSIGNED: @entity73 is a frequently reported side-effect of adjuvant chemotherapy. A large number of animal studies has been performed to examine the neurobiological mechanisms underlying this phenomenon, however, definite conclusions from these studies are restricted due to differences in experimental set-up. We systematically investigated the effects of 6 cytotoxic agents on various neurobiological parameters. C57Bl/6J @entity19 were treated with @entity786 , @entity1205 , @entity632 , @entity1487 , @entity1499 , or @entity1945 . The animals were sacrificed 3 or 15 weeks after treatment and the effect on neurogenesis, blood vessel density, and neuroinflammation was analyzed using immunohistochemistry. None of the cytostatic agents tested affected neurogenesis (cell survival or cell proliferation). Blood vessel density was increased in the hippocampus and prefrontal cortex 3 weeks after treatment with @entity1205 and @entity632 compared with control animals. A decrease in the number of microglial cells was observed in the prefrontal cortex after treatment with @entity786 , @entity1205 , @entity1487 , and @entity1945 compared with control @entity19 . The observed decrease in microglia cells is indicative of @entity32 that occurred after treatment. Overall, the magnitude of the effects was relatively modest. Therefore, we conducted a similar study with @entity1945 in @entity34736 ; @entity678 /b knock out and wildtype FVB @entity19 . Animals were sacrificed 3 weeks after treatment and no notable effect was seen in hippocampal cell differentiation ( @entity20446 ), microglia activation, or blood vessel density. Perhaps the FVB strain is more resistant to the @entity2359 effects of @entity1945 which makes this not the correct model to study the mechanism of chemotherapy-induced @entity73 .
