The anaphase promoting complex is required for memory function in XXXX .

@entity146 @entity19 @entity913 @entity1005 @entity72116 @entity148 @entity179 @entity195 @entity1412
Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and @entity146 . One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome ( @entity1412 /C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the @entity1412 /C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of @entity1412 /C in learning and memory function by generating @entity19 that lack the essential subunit @entity72116 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of @entity148 such as @entity913 or @entity1005 . Since deregulated protein degradation and @entity1412 /C activity has been implicated with @entity179 we also analyzed the effect of @entity72116 deletion in a @entity19 model for @entity195 . In our experimental setting loss of @entity72116 form principle forebrain neurons did not affect the course of pathology in an @entity195 @entity19 model. In conclusion, our data provides genetic evidence that @entity1412 /C activity in the adult forebrain is required for cognitive function.
