Hormone secretion by @entity977 is characterized by @entity101 and XXXX but more regular pulsing.

@entity1 @entity2013 @entity101 @entity5 @entity31605 @entity699 @entity2012 @entity977 @entity701 @entity652
CONTEXT: Hormone secretion by functioning @entity977 is characterized by increased basal (nonpulsatile) secretion, enhanced pulse frequency, amplified pulse mass, and @entity101 . OBJECTIVE: The objective of the study was to quantify (subtle) abnormalities of hormone secretion by @entity977 and the influence of selective pituitary surgery and suppressive medications on these parameters. METHODS: Approximate entropy (ApEn) was quantified with a refined algorithm, @entity31605 by a new method to evaluate sudden short-lived increases in hormone levels, and pulsing regularity, determined with a fully automated deconvolution program. These 3 distinct measures of secretory disruption were compared in untreated and treated @entity1 with @entity2012 , @entity2013 , and @entity699 together with matching profiles in healthy controls. RESULTS: ApEn and @entity31605 were markedly increased in all untreated @entity1 groups and normalized after pituitary surgery in @entity2012 and @entity699 . In contrast, hormone-suppressive medical treatment in @entity2012 and @entity2013 did not normalize ApEn. Spikiness normalized in acromegalic @entity1 but not in @entity2013 . GH and @entity701 pulsing regularity was elevated in @entity2012 and @entity699 , respectively, and normalized after surgery. Medical treatment caused normalization of pulsing regularity in @entity2012 but not in @entity2013 @entity1 . CONCLUSION: This study extends the understanding of disorganized hormone secretion by hyperfunctioning @entity977 . The new findings are increased @entity31605 in all 3 @entity5 groups and increased pulsing regularity in GH- and ACTH-secreting @entity652 . The mechanisms behind the marked pattern irregularity and the selective normalization by surgical and medical therapies are not established yet but may include diminished feedback signaling in addition to the anatomical and functional disorganization of intrapituitary cell networks.
