XXXX and @entity79 : the Marburg @entity0 and Osteoporosis Trial (MABOT II).

@entity23398 @entity79 @entity1 @entity0
OBJECTIVES: The current case-control study is the first to examine the relationship between @entity79 ( @entity79 ) measured by dual-energy X-ray absorptiometry (DXA) and @entity23398 ( @entity23398 ) in pre- as well as postmenopausal @entity1 with @entity0 compared to healthy matched controls. METHODS: Among 1422 @entity1 (premenopausal, n=238, postmenopausal, n=1184), @entity79 and @entity23398 were measured. In total, 541 of the @entity1 had an incident diagnosis of @entity0 (122 premenopausal, 419 postmenopausal) without prior @entity0 treatment. Because of significant intergroup differences in multiple risk factors, a matched-pair analysis (88 premenopausal and 402 postmenopausal @entity1 with and without @entity0 ) was performed. Additionally, a multiple linear regression analysis was undertaken, odds ratios were determined and subjects grouped according to quartiles of DXA and @entity23398 results. RESULTS: DXA results (except the L1-L4 Z-score) were significantly higher in postmenopausal @entity1 with @entity0 even after a matched-pair analysis was performed (p<0.05). In premenopausal @entity1 , we observed no significant differences in DXA results between the groups. @entity23398 results in pre- and postmenopausal @entity1 with @entity0 were significantly higher compared with their matched controls (p<0.001 for all, except for speed of sound in premenopausal @entity1 , p<0.05). Odds ratios for @entity0 risk in the second, third and fourth quartiles compared with the lowest quartile were significantly different for a number of variables. CONCLUSIONS: Our results showed significantly higher @entity79 irrespective of the method and site of measurement in postmenopausal @entity1 with @entity0 compared to controls, even after matching for possible confounders for the first time.
