Primary small cell carcinoma of the XXXX .

@entity1 @entity6552 @entity1819 @entity5 @entity3507 @entity3508 @entity418 @entity356
We report on an 80-year-old @entity1 with primary @entity356 (SmCC). He was admitted to hospital with @entity6552 . An upper gastrointestinal examination revealed an irregularly ulcerated @entity5 , 60 mm in diameter, on the lesser curvature of the @entity1819 body extending to the @entity418 . An endoscopic biopsy revealed a solid proliferation of intermediate-sized @entity5 cells with hyperchromatic nuclei and scanty cytoplasm. Immunohistochemically, the neoplastic cells were positive for @entity3508 and @entity3507 , but negative for carcinoembryonic antigen. No @entity5 was detected on examination of the chest. Therefore, primary gastric SmCC was diagnosed preoperatively. To date, only 38 cases of primary gastric SmCC, including our case, have been reported. By using endoscopic biopsy, approximately two-thirds of cases have been diagnosed incorrectly. In the reported cases of gastric SmCC, the endoscopic findings frequently indicated a @entity5 . Gastric SmCC is clinically aggressive and has an extremely poor prognosis, even when discovered at an early stage. Most @entity1 with gastric SmCC die within 1 year of diagnosis. Although a standard treatment for gastric SmCC has not been established, intensive chemotherapy should be considered to promote long-term survival. We believe that careful examination, including immunohistochemical investigation, is necessary for determining the therapeutic strategy whenever gastric SmCC is suspected during endoscopy.
