XXXX after the fifth decade.

@entity1 @entity3217 @entity75 @entity1596 @entity7462 @entity17577 @entity3204
PURPOSE: To describe the clinical features in @entity1 presenting with @entity17577 after the fifth decade and to analyze laboratory findings in comparison to @entity1596 history and clinical data. DESIGN: Prospective consecutive observational case series. METHODS: A prospective clinical analysis of 27 consecutive @entity1 older than 50 years of age with primary or recurrent @entity17577 was performed during a period of 8 years. These cases account for 12% of all @entity17577 cases irrespective of age indexed in our institution during the same period. Paired serum and @entity7462 samples were tested for anti- @entity3204 gondii IgG, IgM, and IgA antibodies. The presence of @entity3204 DNA in @entity7462 was determined by polymerase chain reaction followed by DNA hydridization method. RESULTS: Although similar in age, two groups were distinguished clinically: 12 @entity1 (44%) presented with usual forms of retinochoroiditis (mean +/- SD, 1.6 +/- 0.5 disk areas [DA] in size); 15 @entity1 (56%) presented with @entity75 , greater than 3 DA in size (mean +/- SD, 5.0 +/- 2.0 DA). The second group showed a higher rate of complications (P =.028) and a poorer visual outcome (P =.015). Twenty-four @entity1 (89%) had intraocular IgG production, 17 (63%) had intraocular IgA production, 3 (11%) had intraocular IgM production, and 12 (44%) had a positive @entity3204 DNA detection. CONCLUSIONS: After the fifth decade, @entity17577 remains an important cause of posterior @entity1596 . The combination of antibody detection by immunocapture tests with @entity3204 DNA detection, both in @entity7462 , allowed the diagnosis of toxoplasmic infection in the atypical cases with @entity3217 .
