Gold nanoparticle-based brachytherapy enhancement in @entity320 using a full Monte Carlo model of the XXXX eye.

@entity1 @entity5 @entity320
The effects of gold nanoparticles (GNPs) in 125I brachytherapy dose enhancement on @entity320 are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom. However, here, the compositions of @entity1 eye have been considered instead of water. Both @entity1 eye and water phantoms have been simulated with MCNP5 code. These simulations were performed for a fully loaded 16 mm COMS eye plaque containing 13 125I seeds. The dose delivered to the @entity5 and normal tissues have been calculated in both phantoms with and without GNPs. Normally, the radiation therapy of @entity5 @entity1 is designed to deliver a required dose to the @entity5 while sparing the surrounding normal tissues. However, as the normal and cancerous cells absorbed dose in an almost identical fashion, the normal tissue absorbed radiation dose during the treatment time. The use of GNPs in combination with radiotherapy in the treatment of @entity5 decreases the absorbed dose by normal tissues. The results indicate that the dose to the @entity5 in an eyeball implanted with COMS plaque increases with increasing GNPs concentration inside the target. Therefore, the required irradiation time for the @entity5 in the eye is decreased by adding the GNPs prior to treatment. As a result, the dose to normal tissues decreases when the irradiation time is reduced. Furthermore, a comparison between the simulated data in an eye phantom made of water and eye phantom made of @entity1 eye composition, in the presence of GNPs, shows the significance of utilizing the composition of eye in ophthalmic brachytherapy dosimetry Also, defining the eye composition instead of water leads to more accurate calculations of GNPs radiation effects in ophthalmic brachytherapy dosimetry.
