Prognosis in XXXX --the benefits of exercise as seen in non-randomised trials.

@entity1 @entity6 @entity1188 @entity583 @entity204
Previous uncontrolled studies suggest that exercise rehabilitation reduces recurrence rates in post- @entity583 @entity1 . Six hundred and ten consecutive post-coronary @entity1 referred to an exercise rehabilitation programme have been followed for an average of 36.5 months (1-8 years). @entity204 amounted to 36 (1.89% p.a.) of which 23 were @entity204 , with an annual death rate averaging only 0.85% after the first year of conditioning had been completed. There were also a total of 21 non-fatal recurrences of @entity1188 . comparison has been made with 700 @entity1 enrolled in the Health Insurance Plan of New York. On the basis of smoothed probabilities for the risk factors reported in the New York series, we should have seen 89 deaths (P less than 0.001). Correcting for differences between the two groups (age and number of @entity6 ) gives a predicted mortality for the Toronto series of 63.5 deaths (3.42% p.a.). This discrepancy in favour of the exercised group is significant in terms of an infinitely large control population (P less than 0.001) and also sample sizes of 610 exercised and 700 control @entity1 (0.01 greater than P greater than 0.001). Unfortunately, formally to prove such a 45% reduction in mortality by way of a randomised control trial would be extremely costly, possibly prohibitively so.
