Infertility rates following POMB/ACE chemotherapy for male and female germ cell XXXX - a retrospective long-term follow-up study.

@entity1 @entity249 @entity4810 @entity5 @entity900 @entity786 @entity4316 @entity2879 @entity3202 @entity1891 @entity1732 @entity1499
The risk of chemotherapy-induced @entity249 in male and female @entity5 ( @entity5 ) survivors is unclear, but may correlate with @entity900 dose. Here, we examine a large series of @entity5 @entity1 for the effect of chemotherapy on those attempting to have @entity1 . Our @entity5 database was screened for nonseminomatous @entity5 @entity1 who had (1). received POMB/ACE chemotherapy ( @entity900 , @entity1891 , @entity1499 , @entity1732 alternating with @entity4316 , @entity786 and @entity2879 ) and (2). stage I male @entity5 @entity1 who were untreated between 1977 and 1996. Fertility was assessed by questionnaire and medical records. A total of 64 of 153 treated and 35 of 115 untreated @entity1 attempted to have @entity1 . In all, 28% (18 out of 64) receiving POMB/ACE were unsuccessful. Radiotherapy (six), @entity3202 (one) or prior @entity249 (three) were implicated in 10 cases, so chemotherapy-induced @entity249 may have occurred in only 11% (eight out of 64). Strikingly, 26% (nine out of 35) of untreated stage I @entity1 also failed to have @entity1 (three had radiotherapy, three prior @entity249 ). Moreover, in treated @entity1 , no association was seen between @entity900 dose and @entity249 . In contrast, radiotherapy significantly increased @entity4810 (P=0.001). Of 28 treated @entity1 who attempted to have @entity1 , 25% (seven out of 28) were unsuccessful. One previously had @entity249 and one subsequently had successful IVF so chemotherapy-induced @entity249 potentially occurred in only 18% (five out of 28) and was not related to @entity900 dose. In conclusion, the risk of chemotherapy-induced @entity249 is low in both male and female @entity5 @entity1 and does not clearly correlate with the cumulative @entity900 dose.
