XXXX modulates nicotinic receptors of substantia nigra dopaminergic neurones.

@entity1239 @entity2568 @entity6786 @entity195 @entity8124 @entity57066
1. The effects of @entity8124 , one of the most common cholinesterase inhibitors used for treatment of @entity195 , were studied on nicotinic receptors (nAChRs)-mediated postsynaptic currents, in dopaminergic neurons of the substantia nigra pars compacta, using the patch-clamp recording technique in slice preparations. 2. @entity8124 (10-100 microM) selectively and reversibly depressed @entity1239 currents, induced by brief puffer pulses, through a glass micropipette positioned above the slice. 3. The peak amplitude fading of the responses generated by repeated test applications of low doses of @entity1239 was accelerated by @entity8124 , while it slowed the recovery of @entity1239 currents after a large, desensitising, dose of the same agonist. 4. @entity8124 depressed even maximal responses to @entity1239 , revealing a noncompetitive mechanism of action; moreover, the inhibition of nAChRs was voltage and time independent. 5. Pretreatment with @entity2568 or @entity57066 did not prevent the reduction of @entity1239 -induced currents. The data indicated direct effect on @entity6786 , independent from the activity of @entity8124 as cholinesterase inhibitor.
