Post Splenectomy Outcome in XXXX .

@entity1 @entity311 @entity715 @entity2395
OBJECTIVES: To evaluate changes in annual blood transfusion requirements and complications after splenectomy in @entity1 with @entity2395 . METHODS: Forty post-splenectomy b-thalassemic @entity1 aged 8-33  y, receiving regular blood transfusions and chelation therapy were included and non transfusion dependant @entity1 were excluded from this retrospective cross-sectional study. Details about their surgery, transfusion requirements, and platelet levels were recorded on a standard proforma. All @entity1 underwent a B-mode and color-coded duplex sonography of the hepatoportal system during the study period. RESULTS: The average ferritin level in the year prior to the study was 4432 mcg/L (range 480-12,200 mcg/L). The annual blood transfusion requirement in the first year and 5  y post splenectomy [mean        SD (138.41        90.38  ml/kg/y); (116        41.44  ml/kg/y)] were significantly different from requirements before splenectomy [(mean        SD) 294.85        226  ml/kg/y; p value <0.001]. There was a significant rise in platelet counts within 24  h post splenectomy with a mean rise of 4,51,000/mm(3) (p value   <   0.001). During the follow up period, infections were noted in 50  % of @entity1 , with @entity311 (18.75  %) being the most common. Doppler study of the portal system in one case showed @entity715 . CONCLUSIONS: A significant sustained fall in annual blood transfusion requirement and a rise in platelet counts occurred post-splenectomy. Increase in annual blood transfusion requirement should be investigated to find the cause.
