Prechemotherapy neutrophil   :   lymphocyte ratio is superior to the platelet   :   lymphocyte ratio as a prognostic indicator for locally XXXX treated with neoadjuvant chemotherapy.

@entity1 @entity1544 @entity1349
UNASSIGNED: The study aimed to evaluate the prognostic significance of prechemotherapy neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, and preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in locally @entity1544 . We analyzed retrospectively locally @entity1544 @entity1 who had received neoadjuvant chemotherapy before undergoing a radical esophagectomy between 2009 and 2012. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio before chemotherapy and before the surgery were calculated. Univariate analyses showed that prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.048, hazard ratio = 2.86; 95% confidence interval: 1.01-8.12) and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.025, hazard ratio = 5.50; 95% confidence interval: 1.23-24.55) were associated significantly with @entity1349 ( @entity1349 ), and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.026, hazard ratio = 3.18; 95% confidence interval: 1.15-8.85) was associated significantly with progression-free survival. However, only prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.024, hazard ratio = 3.50; 95% confidence interval: 1.18-10.40) remained significantly associated with @entity1349 in multivariate analyses. Neither preoperative neutrophil to lymphocyte ratio nor platelet to lymphocyte ratio was associated with @entity1349 or progression-free survival. The prechemotherapy neutrophil to lymphocyte ratio >5 to preoperative neutrophil to lymphocyte ratio  <=5 group showed significantly worse @entity1349 than the prechemotherapy neutrophil to lymphocyte ratio  <=5 to preoperative neutrophil to lymphocyte ratio  <=5 group (P = 0.050). The prechemotherapy platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio  <=130 group (P = 0.016) and platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio >130 group (P = 0.042) showed significantly worse @entity1349 than the prechemotherapy platelet to lymphocyte ratio  <=30 to preoperative platelet to lymphocyte ratio  <=130 group. In conclusions, prechemotherapy neutrophil to lymphocyte ratio is an independent prognostic factor for @entity1349 in @entity1 with @entity1544 treated with neoadjuvant chemotherapy, and, as an adverse prognostic predictor, increased prechemotherapy neutrophil to lymphocyte ratio is superior to platelet to lymphocyte ratio. Maintaining a low neutrophil to lymphocyte ratio and platelet to lymphocyte ratio throughout treatment is a predictor of better @entity1349 .
