[Pathologic diagnosis and histogenesis of primary XXXX of the prostate].

@entity7735 @entity263 @entity5 @entity2580 @entity189 @entity3558 @entity7642 @entity420
OBJECTIVE: To study the histogenesis, pathologic features and differential diagnosis of prostatic primary @entity2580 . METHODS: 10 cases of the primary @entity2580 were detected from 262 cases of @entity263 diagnosed on needle biopsy were investigated by routine pathological, immunohistochemical and histochemical methods, and then compared with 10 cases of signet ring cell @entity189 of the stomach and colon. 3 cases were studied with electron microscopy. RESULTS: 9 cases of @entity263 were associated with concurrent high-grade conventional @entity263 , but at least 25% of the @entity5 consisted of signet ring cells. Only one case was @entity2580 . Neoplastic signet ring cells may be divided into two types: the first type showed formation of intracytoplasmic lumina or vacuole, and the second type had intracytoplasmic accumulation of @entity7735 . Both types of signet ring cells were negative for @entity3558 staining (AB/PAS and @entity7642 ). Therefore they differed from signet ring cell @entity189 of the stomach and colon. CONCLUSIONS: Primary @entity263 is a low-differentiated @entity420 of a special histologic type, which arises from the epithelial cells of the prostate acinus. They can be distinguished from metastatic @entity2580 of the stomach and colon and also from vacuolate degeneration of conventional @entity189 after endocrine or radiation therapy.
