Excellent short-term results with @entity134 -free maintenance immunosuppression in low-risk simultaneous XXXX .

@entity1 @entity8 @entity3446 @entity134 @entity281 @entity618 @entity1140 @entity230
HYPOTHESIS: @entity134 avoidance is possible in simultaneous @entity8 with the use of newer immunosuppressive agents and induction therapy. DESIGN: A retrospective consecutive case review. SETTING: A university tertiary referral center. @entity1 : Medical records of 40 consecutive @entity1 who underwent @entity8 from November 2000 to July 2002 were reviewed. INTERVENTION: The immunosuppression protocol used in this series of @entity1 consisted of Thymoglobulin induction combined with @entity618 , @entity1140 , and @entity3446 for maintenance immunosuppression. @entity230 were used as pretreatment only, given with Thymoglobulin, and were typically discontinued by postoperative week 1. MAIN OUTCOME MEASURES: Graft and @entity1 survival rates, rejection rates of the kidney or pancreas, @entity281 rates, and surgical complication rates. RESULTS: @entity1 , kidney, and pancreas survival rates were 95.0%, 92.5%, and 87.5%, respectively. Biopsy-proven pancreas rejection rates at 1 and 3 months' posttransplantation were 2.5%. Kidney rejection rates at 1 and 3 months were 2.5%. @entity230 were given only to @entity1 with documented transplant rejection. Surgical and medical complications were no different from earlier protocols. CONCLUSIONS: Immunosuppression protocols that do not include maintenance @entity230 have shown minimal rejection in the first 3 months and equivalent @entity1 and graft survival rates compared with protocols that use @entity230 . The potential beneficial long-term impact of @entity134 avoidance will require further study.
