The associations between physical activity and inflammatory markers in high-functioning older XXXX : MacArthur Studies of Successful Aging.

@entity1 @entity32 @entity1851 @entity650
OBJECTIVES: To determine the relationships between recreational activity, house/yard work activity, work activity, and total physical activity and high levels of two peripheral blood markers of @entity32 : @entity650 ( @entity650 ) and @entity1851 ( @entity1851 ). DESIGN: Cross-sectional study. SETTING: Three communities (Durham, NC; New Haven, CT; and East Boston, MA). @entity1 : Eight hundred seventy @entity1 aged 70 to 79 who were in the top third of community-dwelling older @entity1 with respect to physical and cognitive functioning. MEASUREMENTS: Blood levels of @entity650 and @entity1851 and self-reported recreational activity, house/yard work activity, work activity, and total physical activity. RESULTS: The adjusted odds ratios (AORs) for individuals with high levels of recreational activity to have values in the top tertiles of @entity650 and @entity1851 were 0.65 (95% confidence interval (CI) = 0.48-0.87) and 0.70 (95% CI = 0.51-0.95), respectively. The AORs for those with a high level of house/yard work activity to have values in the top tertile of @entity650 and @entity1851 were 0.90 (95% CI = 0.67-1.20) and 0.70 (95% CI = 0.50-0.96), respectively. High levels of house/yard work and recreational activity were independently associated with lower risk of high @entity1851 . CONCLUSION: The association between high levels of recreational activity and lower levels of the inflammatory markers @entity650 and @entity1851 suggests a mechanism for its protective effect and supports interventions that increase physical activity in older @entity1 . Such potential benefits of increased physical activity on inflammatory markers will need to be confirmed in clinical trials.
