Interferons and XXXX : correlation between interferon gamma and interferon-lambda 1 (IL-29).

@entity1 @entity5442 @entity686 @entity379 @entity792 @entity785
BACKGROUND: @entity686 is a newly described cytokine, member of type III interferons family, which is known for its antiviral, anti-proliferative and antitumor activity. Recent studies indicated that this cytokine has also immune-regulatory function, but its role in the pathogenesis of @entity792 is not established yet. We evaluated serum levels of @entity686 in @entity785 ( @entity785 ) @entity1 and healthy controls and its association with @entity379 and clinical manifestations. METHODS: @entity686 and @entity379 serum levels were measured by ELISA from 52 @entity1 with @entity785 and 53 healthy controls. Association of cytokines serum levels was sought with clinical parameters. RESULTS: @entity686 and @entity379 levels in @entity785 @entity1 were significantly higher than those in healthy individuals (24.82        8.78 and 11.04        3.04   pg/ml, p   <   0.0001; 34.11        8.11 and 10.73        2.77   pg/ml, p   <   0.0001, respectively). We found a positive correlation between @entity686 and @entity379 levels in @entity785 @entity1 (p   =   0.0103, r   =   0.3526). @entity379 levels were associated with muscle involvement (p   =   0.0483). CONCLUSION: We first showed raised @entity686 levels in @entity785 @entity1 . Furthermore, we found a correlation between @entity686 and @entity379 levels and an association between @entity379 and @entity5442 . Additional in vitro and in vivo studies are needed to understand @entity686 role in @entity785 .
