Is avolition in XXXX associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback.

@entity1 @entity4270 @entity51 @entity23 @entity161
BACKGROUND: The neurobiological underpinnings of avolition in @entity161 remain unclear. Most brain imaging research has focused on reward prediction @entity51 , but findings are not consistent. In the light of accumulating evidence that both ventral striatum and dorsal caudate play a key role in motivation, we investigated ventral striatum and dorsal caudate activation during processing of reward or loss in @entity1 with @entity161 . METHOD: We used functional magnetic resonance imaging to study brain activation during a Monetary Incentive Delay task in @entity1 with @entity161 , treated with second-generation antipsychotics only, and in @entity23 ( @entity23 ). We also assessed the relationships of ventral striatum and dorsal caudate activation with measures of hedonic experience and motivation. RESULTS: The whole @entity1 group had lower motivation but comparable hedonic experience and striatal activation than @entity23 . @entity1 with high avolition scores showed lower dorsal caudate activation than both @entity23 and @entity1 with low avolition scores. A lower dorsal caudate activation was also observed in @entity1 with deficit @entity161 compared to @entity23 and @entity1 with non-deficit @entity161 . Dorsal caudate activity during reward anticipation was significantly associated with avolition, but not with @entity4270 in the @entity1 group. CONCLUSIONS: These findings suggest that avolition in @entity161 is linked to dorsal caudate hypoactivation.
