Reverse Remodelling of the Atria After Treatment of XXXX with Continuous Positive Airway Pressure: Evidence from Electro-mechanical and Endocrine Markers.

@entity1 @entity13678 @entity3876 @entity27 @entity955 @entity1284
BACKGROUND: Recent studies have suggested a strong association between @entity27 ( @entity27 ) and @entity955 ( @entity955 ). However, the impact of continuous positive airway pressure (CPAP) therapy on reverse @entity13678 in @entity1 with @entity27 is poorly understood. We aimed to determine the impact of CPAP therapy on total atrial conduction time measured by PA tissue Doppler imaging (TDI) interval in @entity1 without history of @entity955 . METHODS AND RESULTS: Thirty-five @entity1 with first diagnosed @entity27 (group 1) and 20 reference @entity1 without @entity27 (group 2) were prospectively enrolled. Group 1 was divided into 25 @entity1 with starting CPAP therapy (intervention group) and 10 @entity1 without CPAP therapy (control group). PA-TDI interval, measured by tissue Doppler imaging, and @entity3876 ( @entity3876 ) were determined at baseline and repeated after 30 days in group 1. @entity1 with @entity27 had a significantly longer PA-TDI interval (131.4  16.0ms vs. 120.1  6.4ms, p<0.001) compared to reference @entity1 . PA-TDI interval shortened significantly after 30 days of CPAP therapy (131  17.1ms vs. 124.6  15.7ms, p<0.001), whereas no significant change was found in the control group (132.6  13.6ms vs. 133.2  13.1ms, p=0.31) and @entity3876 -levels decreased significantly (39.1  50.7pg/ml vs. 28.2  42.4pg/ml, p<0.01), while @entity3876 -levels remained unaffected after 30 days in control group (31.5  20pg/ml vs. 34.4  20.5pg/ml, p=0.41). CONCLUSIONS: Change in PA-TDI interval, as an indirect surrogate marker of @entity13678 , suggests reverse @entity13678 in @entity1 with @entity27 and treated by CPAP. This effect may ensue from decreased atrial pressure or @entity1284 , as indicated by significantly reduced @entity3876 levels. These observations suggest that the substrate pre-disposing to @entity955 may be reversible and moreover can be measured by PA-TDI interval and @entity3876 .
