Effect of XXXX inhalation combined with high-frequency oscillatory ventilation on the prognosis of neonatal severe @entity519 .

@entity227 @entity26 @entity16 @entity519 @entity842 @entity204 @entity306
OBJECTIVE: The current study aimed to analyze the short-term and long-term curative effects of @entity842 (NO) inhalation combined with high-frequency oscillatory ventilation (HFOV) on neonatal severe @entity519 . MATERIALS AND METHODS: A total of 98 neonates meeting the inclusion criteria were retrospectively analyzed. The control group comprised of 48 neonates and the NO inhalation group consisted of 50 neonates. In the control group, conventional mechanical ventilation was replaced by HFOV. In the experimental group, NO inhalation combined with HFOV was performed. The @entity204 rates within 28 days, mechanical ventilation and @entity26 therapy time, and complications in both groups were observed. The survivors in both groups were followed up for 18 months for neural development evaluation. RESULTS: The treatment group showed a significantly lower @entity204 rate and noticeably shorter mechanical ventilation and @entity26 therapy time than the control group (8% vs. 22.9% with t = 4.20 andp < 0.05; 5.84    3.36 days vs. 8.05    5.48 days with t = 2.42 and p < 0.05; and 8.02    4.31 days vs. 12.45    5.14 days with t = 4.63 and p < 0.001). They did not show significant differences with regards to the complications and the incidences of @entity306 , hearing and @entity227 , and severe @entity16 (p > 0.05). CONCLUSION: NO inhalation combined with HFOV significantly decreases the @entity204 rate of neonates with severe @entity519 and reduces their mechanical ventilation and @entity26 therapy time. It does not increase early adverse effects or affect long-term neurodevelopment.
