Hepatocarcinogenesis of regenerative and dysplastic nodules in Chinese XXXX .

@entity1 @entity160 @entity157 @entity204 @entity6349
OBJECTIVES: To determine the development rate of @entity157 and survival of @entity1 diagnosed to have regenerative, and low-grade and high-grade dysplastic liver nodules. DESIGN: Retrospective descriptive study. SETTING: Acute public hospital, Hong Kong. @entity1 : @entity1 with non-malignant liver nodules confirmed by imaging-guided liver biopsy between January 1997 and December 2008. MAIN OUTCOME MEASURES: Rates of @entity157 development and survival. RESULTS: A total of 147 @entity1 with non-malignant liver nodules were followed up over a median duration of 29 months. The initial histological diagnosis included regenerative nodules (n=74), low-grade dysplastic nodules (n=34), and high-grade dysplastic nodules (n=39). The respective cumulative @entity157 development rate during the first, second, third, and fourth year were 3%, 5%, 9% and 12% for simple regenerative nodules, 29%, 35%, 38% and 44% for low-grade dysplastic nodules, and 38%, 41%, 51% and 51% for high-grade dysplastic nodules. The @entity157 development rate was highest in those with high-grade dysplastic nodules. Multivariate analysis showed that histological dysplastic changes were associated with increased @entity160 levels and advanced age, which were both independent predictors of @entity157 development. Histological dysplastic changes, male sex, advanced age, prolonged prothrombin time, and ultrasound appearances were independent predictors of mortality. CONCLUSION: The presence of @entity6349 in liver nodules increased the risk of @entity157 development and @entity204 .
