Stimulation of adrenergic b-receptors enhances XXXX in a porcine eye model.

@entity1 @entity1707 @entity1425 @entity2647 @entity14524 @entity3044 @entity5564 @entity934
PURPOSE: To compare the mydriatic effect of intracamerally injected @entity3044 plus @entity2647 to @entity2647 alone and to @entity1425 in a porcine eye model, aiming to eventually find the best combination of adrenergic substances for surgical @entity5564 in @entity1 . METHODS: In this study, we used 89 intact eyes from newly slaughtered @entity1707 , pretreated with 2.0 mg of intracameral @entity934 . After waiting 60 seconds for miosis to develop, 0.15 ml 0.3% @entity3044 and 0.15 ml 3.0% @entity2647 were injected sequentially with a 90-second interval in 21 eyes. In another 22 eyes, the same substances were given in the reverse order. In 20 eyes, 0.15 ml of 0.025% @entity1425 was injected, and as a negative control 0.15 ml of balanced salt solution was injected in 26 eyes. The pupils were filmed during the treatments, and the mean pupil diameters were measured every 15 seconds from the video recordings. RESULTS: @entity2647 injected after @entity3044 had a larger mydriatic effect than @entity1425 (p < 0.01). Without @entity3044 pretreatment, the mydriatic effect of @entity2647 was significantly smaller than that of @entity1425 (p < 0.05). @entity3044 also exhibited a small mydriatic effect of its own. CONCLUSIONS: The b-receptor stimulator @entity3044 enhances the mydriatic effect of intracameral @entity2647 , indicating a role for the b-receptor in the mydriatic response. Mydriasis mediated by b-receptors may explain why nonspecific adrenergic stimulators such as @entity14524 and @entity1425 can have larger mydriatic effects than the specific a(1)-receptor stimulator @entity2647 .
