Effect of dietary protein restriction on prognosis in @entity1 with XXXX .

@entity1 @entity8 @entity6 @entity2316 @entity204 @entity65 @entity454
BACKGROUND: Recent data suggest that dietary protein restriction improves survival and delays the progression to @entity454 ( @entity454 ) in non- @entity6 @entity8 . The purpose of our study was to determine the effect of dietary protein restriction on survival and progression to @entity454 in @entity2316 . METHODS: A four-year prospective, controlled trial with concealed randomization was performed comparing the effects of a low-protein diet (0.6 g/kg/day) with a usual-protein diet. The study included 82 type 1 @entity6 @entity1 with progressive @entity2316 [pre-study mean decline in glomerular filtration rate (GFR) 7.1 mL/min/year (95% CI, 5.8 to 8.5)]. The main outcome measures were decline in GFR and development of @entity454 or @entity204 . RESULTS: During the follow-up period the usual-protein diet group consumed 1.02 g/kg/day (95% CI; 0.95 to 1.10) as compared with 0.89 (0.83 to 0.95) in the low-protein diet group (P = 0.005). The mean declines in GFR were 3.9 mL/min/year (2.7 to 5.2) in the usual-protein diet group and 3.8 (2.8 to 4.8) in the low-protein diet group. @entity454 or @entity204 occurred in 27% of @entity1 on a usual-protein diet as compared with 10% on a low-protein diet (log-rank test; P = 0.042). The relative risk of @entity454 or @entity204 was 0.23 (0.07 to 0.72) for @entity1 assigned to a low-protein diet, after an adjustment at baseline for the presence of @entity65 (P = 0.01). Blood pressure and glycemic control were comparable in the two diet groups during the follow-up period. CONCLUSION: Moderate dietary protein restriction improves prognosis in type 1 @entity6 @entity1 with progressive @entity2316 in addition to the beneficial effect of antihypertensive treatment.
