Chemotactic activity of plasma and lung lymph in @entity742 with XXXX : effect of hydroxyl radical scavengers.

@entity5694 @entity742 @entity101 @entity26 @entity14455 @entity6922 @entity651 @entity358 @entity1431 @entity1317 @entity2145 @entity526
The formation and release of circulating chemoattractants has been considered to be responsible for the @entity358 and subsequent @entity1317 seen with @entity5694 . @entity26 radicals released from granulocytes can produce these factors. Our purpose was (1) to determine whether chemotaxins are released with @entity5694 and whether the lung is the source of these factors and (2) if there is a cause and effect relationship between the release of chemoattractants and the @entity651 . Lung lymph flow, QL, lymph protein clearance, and vascular pressures were used to monitor lung vascular integrity. @entity526 endotoxin was infused into 12 @entity742 . Six @entity742 were pretreated with @entity14455 ( @entity14455 ), a scavenger of @entity2145 ion radicals. Chemotactic activity (CA) of plasma and lung lymph was determined during baseline, the pulmonary @entity101 phase, and the permeability phase of the @entity651 . It was found that @entity5694 was associated with generation of a granulocyte chemotactic factor in plasma but not in lung lymph. The peak increase in plasma CA occurred after the early pulmonary @entity6922 . Pretreatment with @entity14455 eliminated the increased CA but had no effect on the initial @entity1431 or the @entity651 . It was concluded that (1) the lung is not the major source of increased CA after endotoxin and (2) increased plasma CA occurs but does not appear to be causative of the @entity358 or the granulocyte-induced @entity651 .
