XXXX and pregnancy. Report from French data (1980-1999).

@entity1 @entity204 @entity1577
OBJECTIVE: To study the consequences of pregnancy on @entity1 affected by @entity1577 and to clarify the impact of the disease on maternal and newborn health. DESIGN: Retrospective study. SETTING: Pregnancy survey from the French Cystic Fibrosis Registry. POPULATION: @entity1 with @entity1577 having a pregnancy between 1980 and 1999. METHODS: During the 1980-1999 period, 90 pregnancies in 80 French female @entity1 were registered in the pregnancy survey of the French Cystic Fibrosis Registry. General and clinical data before pregnancy were noted. Outcome of the pregnancy was described. Variations of pulmonary function and body weight during pregnancy were evaluated. Comparison between a group of pregnant @entity1 and a group of non-pregnant cystic fibrotic @entity1 of same age and genotype, followed in the same care centre network, was made. MAIN OUTCOME MEASURES: Spirometric and nutritional parameters, vital status and perinatal health indicators. RESULTS: The outcome was identified for 75 cases: 64 delivered babies (45 at term and 10 prematurely, prematurity rate: 18%), 10 abortions (five spontaneous and five therapeutic or medical), and one maternal death during pregnancy. The proportion of newborns with low weight was 29.8%. Mean maternal weight gain during pregnancy was 5.5 kg. Four affected @entity1 were diagnosed after birth. A decline in the forced expiratory volume in one second (FEV1) and forced vital capacity was observed between the beginning of pregnancy and the year following the delivery. However, no significant difference was found when comparing the variation in the pulmonary function during pregnancy between cases and controls. Moreover, the pulmonary status before pregnancy was better than the status of non-pregnant @entity1 . Among 12 @entity204 recorded after pregnancy, only three happened in the year following the pregnancy. All three @entity1 had an FEV1 < 50% before pregnancy. CONCLUSION: Pregnancy only has a slight adverse effect on maternal health if the @entity1 are in good general condition before starting pregnancy. @entity1 with a better health status are more inclined to initiate and successfully complete a pregnancy. Complete collaboration between @entity1577 and obstetricians should be observed to allow @entity1 to deliver @entity1 in the best conditions.
