Localization of cellular @entity554 -binding proteins suggests specific roles for XXXX in the adult central nervous system.

@entity4878 @entity904 @entity35 @entity1968 @entity554
@entity1968 , the active metabolite of @entity4878 ( @entity904 compounds), is thought to act as a gene regulator via ligand-activated transcription factors. In order to investigate possible roles of @entity4878 and @entity554 -controlled gene expression in brain function, we have used immunohistochemistry to localize the possible presence of two intracellular @entity554 -binding proteins, cellular @entity904 -binding protein type I and cellular @entity1968 -binding protein type I, in the adult @entity35 central nervous system. We find a widespread, yet distinct, presence of these two binding proteins in the brain and spinal cord. Most of the immunoreactivity is neuronal, including cell somata, as well as dendritic and axonal processes and axon terminals. Cellular @entity904 -binding protein type I-immunoreactivity is also found in the walls of cerebral blood vessels, the meninges, the choroid plexus, certain ependymal cells, tanocytes and certain other glial elements. The cellular @entity904 -binding protein type I- and cellular @entity1968 -binding protein type I-immunoreactivity patterns appear to be almost exclusively non-overlapping. Very strong cellular @entity904 -binding protein type I-immunoreactivity is found in the dendritic layers of the hippocampal formation and dentate gyrus. Cellular @entity904 -binding protein type I-immunoreactivity is also present in layer 5 cortical pyramidal neurons and neurons in the glomerular layer of the olfactory bulb. Many other areas, e.g. hypothalamic nuclei and amygdala areas, contain networks of varicose cellular @entity904 -binding protein type I-immunoreactive nerve fibers. The medial amygdaloid nucleus contains strongly cellular @entity904 -binding protein type I-positive neurons. Cellular @entity1968 -binding protein type I-immunoreactivity is more restricted in the adult brain. Strong cellular @entity1968 -binding protein type I-immunoreactivity is, however, found in a population of medium-sized neurons scattered throughout the striatum, in neurons in the glomerular layer of the olfactory bulb, the olfactory nerve and in a group of nerve cells close to the third ventricle in hypothalamus. The remarkably selective patterns of cellular @entity904 -binding protein type I- and cellular @entity1968 -binding protein type I-immunoreactivity discovered in the adult @entity35 brain suggest that @entity4878 have important roles as regulators of gene expression in normal brain function. The high levels of cellular @entity904 -binding protein type I-immunoreactivity found in hippocampus suggest that one such role might relate to brain plasticity.
