[Human cytomegalovirus @entity281 and XXXX ].

@entity1 @entity154 @entity2735 @entity600 @entity281 @entity358
OBJECTIVE: To study the relationship between intrauterine cytomegalovirus (HCMV) @entity281 and @entity600 , and to determine the distribution of tissues infected. METHODS: Autopsy samples of 41 @entity1 with @entity600 and 19 @entity1 with normal appearances were studied. Using polymerase chain reaction (PCR) technique the paraffin embedded specimens of main organs were examined for @entity281 . @entity2735 ( @entity2735 ) was performed in some of the PCR positive tissues in order to define the distribution of HCMV DNA. RESULTS: 19 of the 41 @entity1 (46.34%) with @entity154 were HCMV positive, while 1 in 19 (5.26%) were positive in the control group, and there was significant difference between the 2 groups (P < 0.05), 20.46% (35/171) of the fetal organ samples were HCMV DNA positive in the @entity600 group, but only 1 out of 78 samples (1.28%%) was positive in the pulmonary tissue of the control group. More malformations of the digestive system were presented in HCMV infected babies but no statistical significant difference when compared with other systems. Brain tissue had the highest @entity281 rates (41.37%, 12/29), which was significantly higher than other organs. By @entity2735 technique HCMV DNA was found only in 6 out of 17 PCR positive samples, and they were located at neurons, neurogliocytes, epithelium and interstitial cells of the kidney, and epithelial cells of @entity358 . CONCLUSION: There are strong correlation between @entity281 and @entity600 , and brain is more susceptible to HCMV. By combining PCR and @entity2735 , both sensitivity and distribution of HCMV could be obtained.
