Association between angiotensin I-converting enzyme genotypes, XXXX , and @entity64 .

@entity1 @entity407 @entity64 @entity1289 @entity336 @entity101 @entity6 @entity2791 @entity583 @entity850
The insertion(I)/deletion(D) polymorphism of the @entity1289 ( @entity1289 ) gene has been associated with an increased risk of @entity583 , @entity64 , and with an increased intimal-medial thickness in several populations. The aim of this study was to evaluate whether the @entity1289 I/D genotype is associated with @entity850 of extracranial arteries and @entity64 in middle-aged and aged @entity1 and @entity1 . We studied 388 @entity1 (247 male, 141 female) using Doppler and Duplex ultrasound of the extracranial arteries. @entity1 ' history was obtained by standard questionnaire and by the hospital case records. Genomic DNA was analyzed by polymerase chain reaction (PCR) to identify the I/D polymorphism, with a second insertion specific PCR in samples classified as homozygous @entity336 genotypes to prevent mistyping. The @entity1289 genotype groups ( @entity336 132, ID 164, II 92) were well matched for the basic characteristics. The @entity336 genotype was more common in @entity1 with @entity2791 > or = 50%, compared with @entity1 without @entity850 (59/147 versus 73/241, odds ratio 1.54, 95%-CI 1.01-2.37), but was not associated with a history of @entity64 (30/91 versus 102/297, odds ratio 0.94, 95%-CI 0.57-1.54). The association of the @entity336 genotype with @entity2791 was also present in @entity101 subjects (n = 206, odds ratio 1.76, 95%-CI 0.99-3.17). In the whole group multiple logistic regression analysis revealed that the association of the @entity336 genotype with @entity2791 was independent of age, gender, @entity101 , @entity407 , and @entity6 . In conclusion, the @entity1289 @entity336 genotype is a weak risk factor for hemodynamically relevant @entity850 of extracranial arteries, but not for @entity64 .
