Colocalization of XXXX receptors and epidermal growth factor receptors in @entity0 cells.

@entity0 @entity7514 @entity1722 @entity5 @entity470 @entity12251 @entity22260 @entity22797 @entity7931 @entity1943 @entity7932 @entity22796
BACKGROUND: @entity1943 receptor (SSTR) expression is positively correlated with @entity5 size and inversely correlated with @entity470 ( @entity470 ) levels and @entity5 differentiation. In the present study, we compared @entity22796 -5 and @entity470 -4 mRNA and protein expression in two @entity0 cell lines: MCF-7 (ER+) and MDA-MB-231 (ERalpha-). RESULTS: All five SSTRs and four ErbBs were variably expressed as both cell surface and cytoplasmic proteins. In both cell lines, @entity22797 and @entity22796 were highly expressed, followed by @entity7931 and @entity7932 with @entity22260 being the least expressed subtype, at the protein level. ErbBs were variably expressed with @entity470 as the predominant subtype in both cell lines. @entity470 is followed by @entity7514 , @entity1722 and @entity12251 in MCF-7 at both the protein and mRNA levels. In MDA-MB-231 cells, @entity470 is followed by @entity1722 , @entity12251 and @entity7514 . Our results indicate significant correlations at the level of mRNA and protein expression in a cell and receptor-specific manner. Using indirect immunofluorescence, we found that, in MCF-7 cells, @entity7932 was the most prominent subtype coexpressed with ErbBs followed by @entity22260 , @entity22797 , @entity22796 and @entity7931 , respectively. In MDA-MB-231 cells, @entity22796 colocalized strongly with ErbBs followed by @entity7932 , @entity22797 , @entity22260 and @entity7931 . ErbBs displayed higher levels of colocalization amongst themselves in MCF-7 cells than in MDA-MB-231 cells. CONCLUSION: These findings may explain the poor response to endocrine therapy in ER- @entity5 . Differential distribution of SSTR subtypes with ErbBs in @entity0 cells in a receptor-specific manner may be considered as a novel diagnosis for @entity0 .
