Influence of intact left atrial appendage on hemodynamic parameters of isolated XXXX heart.

@entity63 @entity840 @entity26 @entity998
BACKGROUND: In isolated working @entity840 heart preparations using the conventional technique of cannulating the left atrium via the @entity998 is often insufficiently low (15-20 ml/min). This is a problem in @entity63 reperfusion studies where small absolute differences can be responsible for large relative changes comparing pre- and postischemic values. In an attempt to increase cardiac output, the left atrium was left intact in isolated working @entity840 hearts. The two techniques were compared for hemodynamic parameters and their similarity to the physiological condition. METHODS: The left atrium was cannulated either via the orifices of the pulmonary veins or via an incision in the atrial appendage with its subsequent ligation around the cannula (n = 45-46/group). After 20 min of pressure-volume work cardiac output, heart rate and @entity26 partial pressures were measured and myocardial @entity26 consumption and cardiac efficiency were calculated. RESULTS: Cardiac output was higher in hearts with intact atrial appendage (64 +/- 2 ml/min) than in hearts with ligated atrial appendage (33 +/- 1 ml/min). Myocardial @entity26 consumption (6.1 +/- 0.2 and 8.4 +/- 0.3 micromol/min, resp.) and cardiac efficiency (12.8 +/- 0.6% and 19.9 +/- 0.8%, resp.) were significantly higher in hearts with intact left atrial appendage. CONCLUSIONS: Isolated working @entity840 hearts with an intact left auricle exhibit higher values for important hemodynamic parameters compared to a preparation technique involving ligation of the left auricle.
