Paradoxical perfusion metrics of high-grade @entity11 with an XXXX component: quantitative analysis of dynamic susceptibility contrast perfusion MR imaging.

@entity1 @entity72093 @entity5 @entity2121 @entity11 @entity816 @entity2483 @entity463 @entity3271
INTRODUCTION: The aim of this study is to investigate perfusion characteristics of @entity463 with an @entity3271 component (GBMO) compared with conventional @entity463 ( @entity463 ) using dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) imaging and microvessel density (MVD). METHODS: The study was approved by the institutional review board. Newly diagnosed high-grade @entity11 @entity1 were enrolled (n   =   72; 20 GBMs, 14 GBMOs, 19 @entity816 ( @entity816 ), 13 @entity3271 ( @entity3271 ), and six anaplastic oligoastrocytomas (AOAs)). All @entity1 underwent preoperative MR imaging including DSC perfusion MR imaging. Normalized cerebral blood volume (nCBV) values were analyzed using a histogram approach. Histogram parameters were subsequently compared across each @entity5 subtype and grade. MVD was quantified by immunohistochemistry staining and correlated with perfusion parameters. Progression-free survival (PFS) was assessed according to the @entity5 subtype. RESULTS: GBMO displayed significantly reduced nCBV values compared with @entity463 , whereas @entity5 with @entity2483 (AO and @entity72093 ) exhibited significantly increased nCBV values compared with AA (p   <   0.001). MVD analyses revealed the same pattern as nCBV results. In addition, a positive correlation between MVD and nCBV values was noted (r   =   0.633, p   <   0.001). @entity1 with @entity5 exhibited significantly increased PFS compared with @entity1 with pure @entity816 in each grade. CONCLUSION: In contrast to @entity5 , the presence of @entity2483 in grade IV @entity5 resulted in @entity2121 reduced perfusion metrics and MVD. In addition, @entity1 with GBMO exhibited a better clinical outcome compared with @entity1 with @entity463 .
