Histological heterogeneity of XXXX in @entity628 .

@entity644 @entity8 @entity1347 @entity628 @entity465
@entity628 ( @entity628 ) involves considerable histological heterogeneity in terms of location and quality of the @entity8 . The present study investigated the heterogeneity of @entity1347 in each variant of @entity628 , determined by the Columbia classification, and its clinical relevance. All @entity8 of 80 cases of primary @entity628 were evaluated histologically based on location [tip (TIP), perihilar (PH), or not otherwise specified (NOS)], and quality ( @entity465 or fibrous). Among the 1,299 glomeruli of the 80 biopsy specimens, 210 glomeruli (16.2%) had @entity1347 , comprising 57 (27%) @entity465 TIP, 4 (2%) fibrous TIP, 42 (20%) @entity465 NOS, 86 (41%) fibrous NOS, and 21 (10%) fibrous PH lesions. Each case was also classified into one of the five histological variants of the Columbia classification: collapsing (COL), TIP, @entity465 ( @entity465 ), PH, or NOS. Overlap of @entity1347 in different location categories was seen in the COL, TIP, and PH variants, and heterogeneity of quality was apparent in the COL and @entity465 variants. Histological findings of the @entity465 variant (endocapillary hypercellularity) were observed in nine of the 13 COL variants. Both location and quality correlated with disease duration, degree of @entity644 , and histological severity of @entity8 and tubulo-interstitial lesions. These results demonstrated the histological heterogeneity of @entity8 in all variants of the Columbia classification, except NOS. However, the fidelity of location and dominance of histological features were generally conserved in the TIP and PH variants. The COL and @entity465 variants warrant further investigation because of their overlapping histological findings and apparent histological heterogeneity in the @entity8 .
