Factors related to the presence of IgA class antineutrophil cytoplasmic antibodies in XXXX .

@entity1 @entity5042 @entity4272 @entity254 @entity31 @entity17142 @entity1960
OBJECTIVES: Few studies have assessed the IgA antineutrophil cytoplasmic antibody (ANCA) positivity in @entity31 @entity1 and there is no information about factors related to its synthesis and its status after colectomy. The aims of the study were to assess the serum IgA ANCA prevalence in @entity31 @entity1 , both nonoperated and operated, and to determine the clinical factors related to this positivity. METHODS: Fifty-four @entity31 @entity1 , 63 @entity31 colectomized @entity1 (32 with @entity17142 and 31 with ileal pouch anal @entity254 ), and 24 controls were studied. Antineutrophil cytoplasmic antibodies were detected by specific indirect immunofluorescent assays. RESULTS: The percentage of IgA ANCA was significantly higher in @entity1 with ileal pouch anal @entity254 (45%) than in @entity1 with @entity17142 (22%). There were no differences related to the presence of @entity5042 in ileal pouch anal @entity254 @entity1 . @entity1 with nonoperated extensive @entity1960 (47%) had a significantly higher percentage of IgA ANCA than @entity1 with @entity4272 (19%). Total percentage of ANCA (IgA and/or IgG) tended to be higher in @entity31 and in @entity1 with ileal pouch anal @entity254 than in @entity1 with @entity17142 . However, in ileal pouch anal @entity254 @entity1 , ANCA positivity was mainly due to exclusive IgA production. CONCLUSIONS: A substantial percentage of @entity31 @entity1 , and especially colectomized @entity1 with ileal pouch anal @entity254 , had IgA ANCA, suggesting that ANCA production in @entity31 might be stimulated by an immune reaction in the intestinal mucosa.
