XXXX Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune @entity625 by Modifying Early Adaptive T Cell Responses.

@entity1 @entity32 @entity625 @entity19 @entity4155 @entity792 @entity403 @entity688 @entity2841 @entity309
Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunosuppressive properties. They have emerged as a very promising treatment for @entity792 and @entity32 such as @entity309 . Recent data have identified that @entity2841 -expressing CD4   T cells and Th17 cells have critical roles in the pathogenesis of @entity625 and other @entity32 . Although many studies have demonstrated that MSCs can either prevent or suppress @entity32 , no studies have addressed their modulation on @entity2841 -expressing CD4   T cells and on the plasticity of Th17 cells. To address this, a single dose of @entity1 expanded adipose-derived mesenchymal stem cells (eASCs) was administered to @entity19 with established collagen-induced @entity625 . A beneficial effect was observed soon after the infusion of the eASCs as shown by a significant decrease in the severity of @entity625 . This was accompanied by reduced number of pathogenic @entity2841 (+) CD4(+) T cells in the spleen and peripheral blood and by an increase in the number of different subsets of regulatory T cells like @entity403 (+) CD4(+) T cells and @entity688 (+) @entity4155 (-) CD4(+) T cells in the draining lymph nodes (LNs). Interestingly, increased numbers of Th17 cells coexpressing @entity688 were also found in draining LNs. These results demonstrate that eASCs ameliorated @entity625 after the onset of the disease by reducing the total number of pathogenic @entity2841 (+) CD4(+) T and by increasing the number of different subsets of regulatory T cells in draining LNs, including Th17 cells expressing @entity688 . All these cellular responses, ultimately, lead to the reestablishment of the regulatory/inflammatory balance in the draining LNs.
