Changes in whole-body fat distribution, intrahepatic lipids, and @entity2690 resistance of XXXX adolescents during a low-level lifestyle intervention.

@entity1 @entity28 @entity2690 @entity9744 @entity1386
UNASSIGNED: The aim of this study was to analyze changes in @entity1386 ( @entity1386 ) distribution, intrahepatic lipids (IHL), and @entity2690 resistance (IR) among a group of @entity28 adolescents undergoing a 7-months low-level lifestyle intervention. Thirty-nine @entity28 Caucasian adolescents (mean age 13.9  years, body mass index standard deviation score (BMI-SDSLMS) 2.14) were included. @entity1386 and IHL were determined by T1-weighted magnetic resonance (MR) imaging and single-voxel MR spectroscopy; IR was estimated using the homeostatic model assessment (HOMA-IR). The lifestyle intervention led to a reduction of both BMI-SDSLMS ( @entity1 2.27 to 2.17; @entity1 2.00 to 1.82) and HOMA-IR ( @entity1 6.1 to 4.4 (p   =   0.008); @entity1 6.2 to 4.7 (p   =   0.030)). IHL dropped in both genders ( @entity1 7.5 to 4.3  %; @entity1 4.6 to 3.4  %) positively correlating with HOMA-IR ( @entity1 r   =   0.52; @entity1 r   =   0.68), while in contrast @entity1386 did not change significantly. CONCLUSIONS: Although the lifestyle intervention only slightly reduced BMI-SDSLMS, @entity2690 sensitivity improved in both genders and came along with a marked @entity9744 . This suggests that IHL might play the dominant role regarding @entity2690 resistance in the youth, especially if compared to other @entity1386 compartments such as @entity1386 . What is Known:     MR imaging/spectroscopy can be used to evaluate body fat distribution and intrahepatic lipids in the youth.     The strength of associations between body fat compartments and @entity2690 resistance is under scientific debate. What is New:     The study emphasizes that even a low-level lifestyle intervention has a beneficial effect.     The study suggests that intrahepatic lipids are an important factor in the development of @entity2690 resistance.
