Selective antipolysaccharide antibody deficiency associated with peripheral blood XXXX + B-cell predominance.

@entity1 @entity12587 @entity6078 @entity5893 @entity7462 @entity942
BACKGROUND: Primary @entity7462 vary from complete absence of B cells and/or serum immunoglobulin to lacunar deficits involving specific antibody responses to polysaccharides. OBJECTIVES: We compared the B-cell @entity5893 expression in @entity1 with selective antipolysaccharide antibody deficiencies (SPADs), @entity6078 ( @entity6078 ), and @entity12587 and in normal control subjects. METHODS: Five @entity1 populations were evaluated: (1) @entity1 with severe SPAD (no protective serologic postvaccine response to any of 12 polysaccharide antigens tested); (2) @entity1 with intermediate SPAD (diminished response to polysaccharide antigens and adequate response to 1 to 3 of 12 serotypes tested); (3) patients with @entity12587 ; (4) @entity1 with @entity6078 ; and (5) age-matched control subjects. Blood was collected from all @entity1 and evaluated by using flow cytometry. Results were compared by using the Student t test. RESULTS: @entity1 with severe @entity942 had a marked predominance of @entity5893 + B cells in the peripheral blood (93% to 97% of total B cells, n = 2). The intermediate SPAD group had a mean @entity5893 + B-cell percentage that was significantly higher than that of the age-matched control group (87. 4%, n = 7, vs 52.5%, n = 20; P =.007). @entity1 with @entity6078 and @entity12587 had mean @entity5893 + B-cell percentages that were similar to those of the age-matched control subjects. CONCLUSIONS: Our studies demonstrate that @entity1 with SPAD had a markedly increased percentage of @entity5893 + B cells in the peripheral blood as compared with age-matched control subjects and @entity1 with other @entity7462 . This observation suggests that an association may be present between @entity5893 + B-cell predominance and SPAD.
