Neuropharmacology of @entity1239 : effects on the autoregulation of XXXX release by substance P and methionine enkephalin in rodent cerebral slices and toxicological implications.

@entity286 @entity10133 @entity1239 @entity2999 @entity4874 @entity1617 @entity141 @entity715 @entity13624 @entity934
1. The neuronal release of @entity934 ( @entity1617 ) and its autoregulation by neuromodulators, substance @entity10133 ) and @entity2999 (MEK), have been studied using superfused rodent cerebral slices. @entity1239 exerts significant effects on autoregulation of @entity1617 release, which may have toxicological implications. 2. Positive and negative feedback systems have been postulated for autoregulation of @entity1617 release. The components of the positive feedback system include a muscarinic (Ms) receptor, SP, and activation of @entity141 influx. Low levels of @entity1617 in the biophase of the cholinergic synaptic gap may trigger the positive feedback system, and high levels of @entity1617 may trigger the negative feedback system. 3. There are also neuronal pathways for direct reciprocal regulations of SP and MEK. 4. Low concentrations of @entity1239 triggers the release of @entity1617 followed by MEK and SP. Release of SP causes @entity13624 . 5. @entity1239 and its metabolite, @entity4874 , activate platelet activating factor (PAF)-hydrolase and thereby enhance the turnover rate of PAF. This effect may contribute to @entity286 -induced @entity715 in peripheral and central nervous systems.
