Assessment of coronary remodeling in stenotic and nonstenotic XXXX by multidetector spiral computed tomography.

@entity1 @entity850 @entity731 @entity2915 @entity5707 @entity453 @entity4649
OBJECTIVES: This study was designed to investigate whether contrast-enhanced @entity4649 ( @entity4649 ) permits assessment of remodeling in @entity453 . BACKGROUND: With sufficient image quality, @entity4649 permits noninvasive visualization of the coronary arteries, but its ability to assess remodeling has not been evaluated. METHODS: Out of 102 @entity1 in whom @entity4649 (16-slice scanner, intravenous contrast, 0.75-mm collimation, 420 ms rotation) was performed before invasive coronary angiography, 44 @entity1 with high-quality @entity4649 data sets showing @entity731 in a proximal coronary artery segment were chosen for evaluation. In multiplanar reconstructions orthogonal to the coronary artery, the cross-sectional vessel area was measured for the respective lesion and for a reference segment proximal to the lesion. The " @entity5707 Index" was calculated by dividing the vessel area in the lesion by the reference segment. Results were correlated to the presence of @entity850 (>50% diameter reduction) in invasive angiography. In a subset of 13 @entity1 , @entity4649 measurements were verified by IVUS. RESULTS: Reference vessel area was not significantly different between nonstenotic versus stenotic lesions (20 +/- 8 mm(2), n = 23 vs. 22 +/- 8 mm(2), n = 21). The mean @entity5707 Index was significantly higher in nonstenotic than in stenotic lesions (1.3 +/- 0.2 vs. 1.0 +/- 0.2, p < 0.001). In five stenotic lesions, "negative remodeling" ( @entity5707 Index < or = 0.95) was observed. @entity2915 and @entity5707 Indices measured by @entity4649 correlated closely to IVUS (r(2) = 0.77 and r(2) = 0.82, respectively). CONCLUSIONS: Multidetector spiral CT may permit assessment of remodeling of @entity453 in selected data sets of sufficient quality.
