Prognostic value of XXXX in @entity1 with primary @entity2590 .

@entity1 @entity2214 @entity27487 @entity7139 @entity417 @entity2590 @entity3052 @entity2263 @entity2008 @entity2131 @entity2246
Chromosome analyses were carried out on bone marrow cells from 43 consecutive @entity1 with primary @entity2590 ( @entity2590 ), classified according to the French-American-British (FAB) cooperative group criteria. The objective was to evaluate the prognostic value of @entity2008 and of an @entity7139 for early death from @entity3052 ( @entity3052 ) and/or @entity2131 ( @entity2131 ). @entity1 were subdivided into two main groups: (1) @entity7139 ( @entity7139 ), grouping @entity1 with @entity417 ( @entity417 ) and @entity417 with @entity27487 (RARS), and (2) @entity7139 ( @entity7139 ), grouping @entity1 with @entity7139 ( @entity7139 ) and @entity7139 in transformation (RAEBt). There were 29 @entity1 with @entity7139 and 14 with @entity7139 . The median time of observation was 26 months for @entity7139 and 12 months for @entity7139 . Ten @entity7139 @entity1 (34%) and 11 @entity7139 @entity1 (78%) had @entity2008 . Among the ten @entity7139 @entity1 with @entity2214 , one (10%) died from @entity3052 , while of 19 @entity7139 @entity1 with a normal karyotype, two (10%) died from @entity3052 or @entity2131 . The median survival for @entity1 with @entity7139 and an abnormal karyotype was not reached. In contrast, eight of the 11 @entity7139 @entity1 with @entity2008 (74%) died from @entity3052 or @entity2131 . The median survival in this sub-group was 7 months. By using a Cox proportional hazard regression analysis, it was determined that a karyotype abnormality was not a significant predictory of survival once the contribution of the @entity7139 / @entity7139 variable was taken into account. Being in the @entity7139 group was associated with a relative risk of 10.6 of dying from @entity3052 or @entity2131 ( @entity2263 .36, @entity2246 ( @entity2246 ) = 0.68, P = .0001). We conclude that classifying @entity1 according to an @entity7139 will lead to a better prediction of survival than determining karyotype abnormality.
