XXXX effect on free fatty acid and diacylglycerol accumulation during experimentally induced @entity2657 .

@entity5204 @entity2657 @entity4600 @entity4 @entity9525 @entity1426 @entity1474 @entity619 @entity13286 @entity3899 @entity35 @entity1718
Free @entity1718 (FFA), @entity13286 (DG), and water content were measured in the right and left cerebral hemispheres of @entity35 with @entity2657 cryogenically induced to the right cerebral hemisphere. The effect of @entity619 pretreatment was also studied. Twenty-four hours after lesion, maximal @entity4 was attained concomitant with an accumulation of FFA (8.5-fold) and DG (2.9-fold). @entity1474 ( @entity5204 ), primarily @entity4600 , increased greatly in both lipid pools. In the contralateral hemisphere, only DG levels increased, especially those containing @entity9525 and @entity3899 , which increased by almost 50%. By 48 h, FFA had decreased 60%, whereas DG had attained sham levels. These changes occurred prior to @entity4 resolution. @entity619 decreased the degree of @entity4 and the accumulation of @entity5204 -containing DG by 30% in both hemispheres. There was a complete inhibition of FFA and @entity1426 accumulation in the lesioned side. These results suggest that @entity619 : (1) inhibits phospholipases A2 that, in turn, decrease membrane phospholipid breakdown; and (2) has a limited effect on the enzymatic systems involved in @entity5204 -DG accumulation. Hence, in experimentally induced @entity2657 , @entity5204 -containing DG, rather than FFA, may be related closely to the spreading of @entity4 fluid.
