Electrical behaviour of myenteric neurones in the gastric corpus of the XXXX .

@entity5128 @entity840 @entity1022 @entity973 @entity356 @entity141 @entity528
1. Electrical behaviour of ganglion cells in the myenteric plexus of the @entity840 stomach was investigated using intracellular recording methods. 2. Three subpopulations were identified and classified for convenience of discussion as @entity356 . Gastric I neurones were characterized by repetitive spike discharge during depolarizing current pulses and by higher input resistance than the other types. @entity528 discharged one or two spikes only at the onset of long-lasting depolarizing current pulses. Gastric III neurones did not discharge spikes to depolarizing current pulses and had higher membrane potentials and lower input resistances than the other types. Non-stimulus evoked discharge ('spontaneous' discharge) did not occur in any of the neurones. 3. Resting membrane potentials were generated primarily by resting K+ conductance, but were smaller than the estimated K+ equilibrium potential. Analysis based on the constant field equation predicted lower K+ conductance in gastric I than in gastric III neurones. 4. Action potentials in gastric I and II neurones were suppressed or blocked by @entity1022 . Spikes that were broadened by @entity5128 appeared to have an inward component of @entity141 current. 5. Hyperpolarizing after-potentials were associated with the spikes of both kinds of neurones. These after-potentials had much shorter duration (less than 300 ms) than the post-spike hyperpolarization of AH/type 2 intestinal neurones and unlike intestinal neurones there was no latency between the positive after-potential of the spike and the onset of the hyperpolarization. After-hyperpolarization in the gastric neurones was enhanced when the spikes were broadened by @entity5128 and was suppressed by removal of @entity141 from the bathing solution. 6. Treatment with either @entity5128 or @entity973 enhanced excitability and induced 'spontaneously' occurring repetitive spike discharge. 7. The electrophysiological behaviour of gastric myenteric neurones differed significantly from intestinal neurones. This was interpreted as specialization of the neural networks that control and co-ordinate the activity of vastly different effector systems in the two regions of the alimentary canal.
