Mu opioid receptors and XXXX at the site of a peripheral nerve injury.

@entity1931 @entity10971 @entity1337 @entity1510 @entity1286 @entity35 @entity8638 @entity4847 @entity9
Opioid ligands may exert antinociception through receptors expressed on peripheral afferent axons. Whether local opioid receptors might attenuate @entity9 is uncertain. In this work, we examined the function and expression of local mu opioid receptors (MORs) associated with the @entity8638 ( @entity8638 ) model of sciatic @entity9 in @entity35 . Low-dose @entity1286 or its carrier were percutaneously superfused over the @entity8638 site with the injector blinded to the identity of the injectate. @entity1286 , but not its carrier, and not equimolar systemic doses of @entity1286 reversed thermal @entity1931 in a dose-related, @entity1510 -sensitive fashion. Moreover, @entity1337 was conferred at both 48 hours and 14 days after @entity8638 , times associated with very different stages of nerve repair. Equimolar local DAGO ([D-Ala2, N-Me-Phe4, Gly5-(ol)] @entity10971 ), a selective MOR ligand, provided similar @entity1337 . Local @entity1286 also attenuated mechanical @entity1931 . MOR protein was expressed in axonal endbulbs of Cajal just proximal to the injury site, in aberrantly regenerating small axons in the @entity4847 around the @entity8638 site and in residual small axons distal to the @entity8638 lesion. Sensory neurons ipsilateral to @entity8638 had an increase in the proportion of neurons expressing MOR. We suggest that local MOR expressed in axons may be exploited to modulate some forms of @entity9 .
