Recurrent XXXX : treatment strategies and survival analysis in a 20-year period.

@entity5 @entity1 @entity135
Following clinical diagnosis of a recurrent @entity5 , curative treatment is seldom available. Depending on the size of the recurrent @entity5 and the @entity1 's general health condition extensive surgical resections and reconstructions are avoided in favor of non-surgical palliative intended treatment modalities. According to the literature location of the @entity5 , @entity5 size, as well as R-1- and R-2-resection rates are the most frequent reasons for the development of recurrent @entity5 . In a retrospective evaluation a population of 1000 @entity1 who were treated for a primary @entity135 during the period from 1979 to 1996 were analysed descriptively. Survival probabilities of @entity1 with recurrent @entity5 were calculated according to the product-limit method by Kaplan-Meier, different treatment concepts were compared and analysed with the log-rank test for significant differences. The largest proportion of primary @entity5 involved the floor of mouth ( n = 369, 36.9%). A total of 198 @entity1 (19.8%) developed a recurrent @entity5 ; 79.8% of @entity1 experienced a recurrent @entity5 within two years following primary treatment. Within the group of T1/T2 @entity5 the incidence of recurrent @entity5 was 28.9%, whereas the incidence in the T3/T4 group was 44.6%. Tumor infiltration of the resection margins was detected in 12.9%. In line with the literature, @entity5 infiltration of the resection margins is a relevant prognostic factor, therefore intraoperative frozen section must be recommended. Treatment with curative intention, in particular extensive surgical resections, is seldom possible, and requires always a very intensive discussion with the @entity1 .
