Histopathological evaluation of laser thermocoagulation in the @entity1 prostate: optimization of laser irradiation for XXXX .

@entity1 @entity39 @entity235 @entity75 @entity1067
We have previously shown in a @entity235 prostate model that a noncontact low power neodymium:YAG laser regimen of 15 watts for 180 seconds yields a larger volume of @entity39 than the currently recommended high power regimen of 50 watts for 60 seconds. These 2 regimens have not yet been compared in @entity1 . The objective of this study was to evaluate histopathologically the thermocoagulation effect of these 2 laser regimens in the @entity1 prostate and the effect of the spatial distribution of the laser lesions on the extent of @entity39 . The study was conducted in 10 @entity1 undergoing radical prostatectomy or cystoprostatectomy. The laser treatment was given transurethrally 1 hour before removal of the specimen. There were no fractures of the prostate. The @entity39 did not reach the peripheral zone and it was minimal in areas rich in fibromuscular tissue, such as the bladder neck. At times, nodular @entity1067 was unaffected. A 4-quadrant treatment in the same plane often yielded small nonconfluent lesions. @entity75 in the same plane yielded approximately 30% greater depth of @entity39 , which was achieved when 3 or 4 lesions were created on each side of the prostate (per single transverse plane). Likewise, @entity39 observed with 15 watts for 180 seconds was approximately 40% greater than that noted with the 50 watts for 60 seconds regimen. Our findings suggest that noncontact laser prostatectomy is a safe procedure that can be improved by modifying the laser regimen and the spatial distribution of lesions.
