@entity7493 modifies the production of @entity1618 in response to lipopolysaccharide (LPS) in a XXXX model.

@entity7493 @entity19 @entity1618 @entity281 @entity465 @entity58 @entity1210
Malnutrition modifies resistance to @entity281 by impairing a number of physiological processes including hematopoesis and the immune response. In this study, we examined the production of @entity58 ( @entity58 ) and @entity1618 in response to lipopolysaccharide (LPS) and also evaluated the cellularity of the blood, bone marrow, and spleen in a @entity19 model of @entity7493 . Two-month-old male Swiss @entity19 were subjected to @entity7493 ( @entity7493 ) with a low-protein diet (4%) as compared to the control diet (20%). When the experimental group lost approximately 20% of their original body weight, the animals from both groups received 1.25 microg of LPS intravenously. The cells in the blood, bone marrow, and spleen were counted, and circulating levels of @entity58 and @entity1618 were evaluated in animals stimulated with LPS. Cells from the spleen, bone marrow, and peritoneal cavity of non-inoculated animals were collected for culture to evaluate the production of @entity58 and @entity1618 after stimulating these cells with 1.25 microg of LPS in vitro. Malnourished animals presented @entity1210 and a severe reduction in bone marrow, spleen, and peritoneal cavity cellularity before and after stimulus with LPS. The circulating levels of @entity1618 were increased in malnourished animals inoculated with LPS when compared to control animals, although the levels of @entity58 did not differ. In cells cultured with LPS, we observed high levels of @entity1618 in the bone marrow cells of malnourished animals. These findings suggest that malnourished @entity19 present a deficient immune response to LPS. These alterations may be partly responsible for the @entity465 observed in these malnourished @entity19 .
