Multidrug resistant enteroaggregative @entity526 coli XXXX in rural southern Indian population.

@entity1 @entity799 @entity5176 @entity294 @entity645 @entity802 @entity869 @entity791 @entity526
Enteroaggregative @entity526 coli (EAEC) has been implicated in acute and persistent @entity294 in @entity1 , adults, and in @entity645 / @entity791 @entity1 . Enteroaggregative @entity526 coli strains isolated from different parts of the world show a low to high level resistance to antimicrobial agents. The aim of the present study was to determine antimicrobial susceptibility in vitro among 64 EAEC strains isolated from @entity1 and adults with @entity294 . 270 @entity526 strains were isolated from @entity1 and adults. A total of 64 were identified as EAEC by multiplex PCR targeting 2 specific genes, AggR and EAST, from July 2006 to July 2007. Susceptibility to various antibiotics was checked using the Kirby Bauer disk diffusion method. Disk diffusion testing for 11 commonly used antimicrobial agents showed EAEC resistant to @entity799 , @entity869 and @entity802 . 75% of strains isolated showed multidrug resistance, i.e. resistance to >3 antimicrobial agents. Most of the isolates showing multidrug resistance were from @entity1 below 5 y of age. An increase in resistance of EAEC strains to @entity5176 was observed in the study. Our study indicated that EAEC resistance in southern India is much higher than that reported from other parts of country. Our study also showed that monitoring sensitivity to antibiotics commonly used in acute and persistent @entity294 is necessary for optimum selection of effective antibiotics and elimination of antibiotics with little therapeutic value. Further clinical epidemiological and laboratory studies are needed to clarify these issues.
