@entity5 outcome prediction to high-dose rate brachytherapy using quantitative magnetic resonance imaging analysis of XXXX response to external beam radiotherapy.

@entity1 @entity5 @entity15855 @entity3846 @entity420 @entity1349
BACKGROUND AND PURPOSE: In order to assess @entity5 regression and outcomes, a volumetric analysis was conducted for cervical @entity5 @entity1 treated with magnetic resonance imaging (MRI)-based image-guided brachytherapy (IGBT). MATERIALS AND METHODS: Consecutive @entity1 with FIGO stage @entity3846 -IVA cervical @entity5 receiving chemoradiation from 2007 to 2013 were identified, excluding @entity1 with perineal template-based interstitial brachytherapy or without undergoing MRI. A ring and tandem applicator  interstitial needles was used. T2-weighted imaging was completed following applicator insertion. Gross @entity5 volumes (GTVs) were retrospectively contoured: initial GTV (GTVPre-EBRT), GTV at first brachytherapy (GTVIGBT) and percent residual GTV at first brachytherapy (% GTVResidual). RESULTS: Eighty-four @entity1 were identified. With 20.8-month median follow-up, two-year estimates of local control (LC), disease-free survival (DFS) and @entity1349 ( @entity1349 ) were 91.3, 79.8, and 85.0%, respectively. Multivariate Cox regression revealed @entity420 (HR 5.88, p=0.03) and GTVIGBT (HR 1.17, p<0.01) as predictors for local failure. GTVIGBT>7.5cc was associated with inferior 2-year LC (75.0 vs. 96.6%, p<0.01), DFS (42.6 vs. 91.6%, p<0.01) and @entity1349 (65.2 vs. 91.5%, p<0.01). No difference in mean @entity15855 D90 EQD2 was seen between the groups (p=0.61). CONCLUSION: Aside from known benefits of IGBT, MRI-based planning allows for assessment of @entity5 regression and prognosticates @entity1 .
