Mode of delivery and risk of @entity932 in newborns with severe XXXX : a multicentre study in Gulf region.

@entity1 @entity932 @entity447 @entity1050 @entity365
INTRODUCTION: The optimum mode of delivery in a known carrier of a @entity447 is still an issue of debate. AIM: This study was conducted to report a multicentre experience in Gulf Cooperation Council (GCC) on the incidence of @entity932 ( @entity932 ) in newborns with severe @entity447 delivered by different modalities. METHODS: We have conducted a retrospective/prospective multicentre cohort study including a total of seven hospitals distributed in four GCC countries between 1998 and Jan 2015. A total of 163 @entity1 with severe @entity447 (factor VIII <1%) were enrolled in this study, age ranged between 2 weeks to 18 years. RESULTS: Most of the @entity1 were born by @entity365 ( @entity365 ) (131, 80.4%), whereas 26 @entity1 (16%) were born by @entity1050 and only six @entity1 were born by instrumental delivery (3.7%), five of them by vacuum and one was delivered using forceps. Five out of 163 @entity1 developed @entity932 during the first 2 weeks of life (3.1%). Two of them were born by @entity365 (2/131; 1.5%) and two were born by instrumental delivery (2/6; 33.3%). Only one @entity1 among those who were born by caesarean section developed @entity932 (1/26; 3.8%). Assisted vaginal delivery was associated with a significant risk of @entity932 , in comparison to @entity365 and @entity1050 (P = 0.0093). CONCLUSION: Normal vaginal delivery is still considered a safe journey through the birth canal for haemophilic newborns particularly in this area of the world. Larger prospective studies might be needed to define an evidence-based optimal mode of delivery for the @entity447 carrier expecting an affected @entity1 .
