Surgical treatment of liver metastases from XXXX : experience of a single institution.

@entity1 @entity204 @entity5 @entity14
BACKGROUND: This report analyses an experience with 42 liver resections for metastatic @entity14 . METHODS: Forty-two @entity1 underwent curative resection for liver metastasis from @entity14 between January 2004 and December 2007, with a follow up period that ranged from 3 to 66 months. In this retrospective study, early postoperative 30 day mortality and morbidity in addition to the effects of @entity5 , type of resection, number and size of the @entity5 , synchronous or metachronous metastases, resection margin, sex, age and chemotherapy protocol on three year survival were analyzed retrospectively. Univariate analyses of survival were estimated using the Kaplan-Meier method. Multivariate analysis was evaluated using Cox regression method. The value of P<0.05 was accepted as significant. RESULTS: Early postoperative morbidity and mortality rates were 7.14% and 0%, respectively. Fourteen @entity1 died during the follow-up period of 3 to 66 months (mean, 40.40  12.87). Median survival was 56 months and three year survival rate was 71.30%. Recurrence occurred in 11 @entity1 (26.00%) after liver resection and additional surgery was performed for two of them. At univariate analysis, the number of @entity5 (<4), @entity5 size (<4 cm), type of resection and negative resection margins were significantly correlated with three year survival. Sex, age, @entity5 , synchronous or metachronous metastasis, recurrence and chemotherapy protocol were not predictive of long-term prognosis. Multivariate analysis revealed that @entity5 size>4 cm and presence of more than four @entity5 before surgery were associated with a 5.89 and 2.18-fold increased risk of @entity204 , respectively. CONCLUSION: Curative resection is one of the most important treatment options that can demonstrate long-term survival for @entity1 .
