Double ( @entity5157 and @entity58378 ) immunoglobulin E reactivity in @entity1 @entity56 to Hymenoptera venom: the role of cross-reactive carbohydrates and XXXX consumption.

@entity1 @entity97 @entity167 @entity1735 @entity58378 @entity56 @entity5157
BACKGROUND: Immunoglobulin (Ig) E-mediated sensitization to N-glycans (cross-reactive @entity1735 determinants, CCDs) may induce double IgE reactivity to @entity5157 venom ( @entity97 ) and yellow jacket venom (YJV) in @entity1 who are monosensitized to either of these venoms. @entity167 consumption is associated with increased IgE levels and possibly with sensitization to CCDs in the general population. OBJECTIVES: This study investigated the factors associated with double ( @entity97 and YJV) IgE reactivity in @entity1 who are @entity56 to Hymenoptera venom, and in particular, @entity167 consumption. METHODS: Ninety-one @entity1 with Hymenoptera allergy (68 to @entity97 , 19 to YJV, and 4 to both venoms) were studied. Determinations included a multiallergen IgE test and IgE to @entity97 , YJV, natural (glycosylated) @entity97 phospholipase-A2 (nPLA2), recombinant (nonglycosylated) @entity97 phospholipase-A2 (rPLA2), MUXF (the N-glycan from bromelain), natural (glycosylated) rubber latex, total IgE. Double reactivity was defined as an IgE level > 0.35 kU(A)/L to @entity97 and YJV. RESULTS: Double reactivity was observed in 28/87 (32%) clinically monosensitized @entity1 . Double reactivity was associated with high levels of total IgE, MUXF-specific IgE, nPLA2-specific IgE, latex-specific IgE, and false-positive results in the multiallergen IgE test, but not with rPLA2-specific IgE. @entity167 consumption was associated with double reactivity and with high levels of IgE to glycosylated allergens after adjusting for confounders in the multivariate analysis. CONCLUSIONS: Sensitization to CCDs and clinically irrelevant double ( @entity5157 and @entity58378 ) IgE reactivity are common among Hymenoptera venom- @entity56 @entity1 who drink @entity167 . A simple questionnaire about @entity167 consumption could be useful when interpreting levels of specific IgE in these @entity1 .
