Natural history of asymptomatic XXXX .

@entity5 @entity1 @entity356 @entity674
GOAL: To assess the natural history of @entity356 (SETs) of  <=30 mm in size and to determine their optimal management. BACKGROUND: Definitive guidelines have not been formulated for the management of small gastric SETs, owing to a lack of knowledge of their natural history and insufficient long-term follow-up. STUDY: We retrospectively reviewed the upper endoscopy and/or endoscopic ultrasound results of 989 @entity5 diagnosed as gastric SETs of  <=30 mm in size between July 1997 and October 2008 with a minimal follow-up of 3 months. A gastric SET was defined as a mass covered with normal appearing mucosa on upper endoscopy and a @entity5 located in the second, third, or fourth layer on endoscopic ultrasound. RESULTS: Of the 989 SETs in 948 @entity1 , 84 (8.5%) showed significant changes in size, and/or echogenicity, and/or morphology at a median 24 months (range, 3 to 123 mo). Estimated growth rates differed significantly by initial size (<10 mm, 0.14 mm/mo; 10 to 20 mm, 0.22 mm/mo; 20 to 30 mm, 0.31 mm/mo; P=0.003). Twenty-five @entity1 with @entity5 showing changes in size and/or echogenicity underwent surgical/endoscopic resection; of these, 19 @entity1 were diagnosed with @entity674 ( @entity674 ), of which 3 @entity1 were considered at high risk, 4 at intermediate risk, 10 at low risk, and 2 at very low risk. In a univariate analysis, @entity674 showed a significant change in @entity5 size during follow-up compared with other @entity5 (P=0.037). However, multivariate analysis did not show a statistical significance in size change between @entity674 and other @entity5 (hazard ratio 1.754; 95% CI, 0.575 to 5.291; P=0.326). CONCLUSIONS: Only 8.5% of gastric SETs of  <=30 mm in size showed significant changes at a median 24 months. SETs of 10 to 30 mm in size grew significantly more rapidly than SETs <10 mm.
