[Studies on the possibility of immunoprophylaxis of XXXX ].

@entity5 @entity1 @entity189
The extremely high mortality rate of @entity5 requires every effort to avoid or decrease the incidence of @entity5 . In this paper the possibility of an immuno-prophylaxis of @entity189 is discussed. A study was undertaken, whether or not the incidence of @entity189 is decreased in @entity1 after the change of the status of immunity developed by typhus. In the years after the war (1945-1947) over 5400 @entity1 suffering from typhus had been reported in Vienna (according to the law in Austria) and about 600 died from this disease. In 1967 more than 2800 could be determined still alive and 535 had died in the meantime. The mortality rate of @entity5 was calculated and compared in age- und sex-adjusted groups with the relative @entity5 mortality rate of the whole population of Vienna in the average of the years 1959-1963. The statistical evaluation shows a lower @entity5 mortality of @entity1 suffering from typhus at an earlier time. This difference seems to be significant (chi 2test, p less than 0.05) in @entity1 of the age group 30-50 and in @entity1 35-65 years of age. Additionally in two regions of Austria (Ober  sterreich, Burgenland) similar observations were made, but with no statistical significance because of the small numbers. Some diagnostic insecurities during war time require the restriction of conclusions. On the basis of clinical observations and results from animal experiments the possibility of an immuno-prophylaxis of @entity189 by unspecific stimulation of the defensive mechanism is supposed, and a prospective study of volunteers, whose level of defense is kept optimal by adequate frequent repetition of the stimulation, is suggested. The incidence of @entity189 would have to be compared to a control group.
