Twenty-Second versus Sixty-Second Dilation Duration in Endoscopic XXXX for the Treatment of Small Common Bile Duct Stones: A Prospective Randomized Controlled Multicenter Trial.

@entity1 @entity384 @entity788
BACKGROUND/AIMS: Endoscopic @entity384 (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for the treatment of common bile duct (CBD) stones. However, there is no established consensus on the optimal @entity384 ( @entity384 ). We prospectively evaluated the efficacy and post-endoscopic retrograde cholangiopancreatography (ERCP) complications between the 20- and 60-second EPBD groups. METHODS: A total of 228 @entity1 with small CBD stones ( <=12 mm) were randomly assigned to undergo EPBD with a 20- or 60-second duration at six institutions. We evaluated baseline @entity1 characteristics, endoscopic data, clinical outcomes, and procedure-related complications. In addition, we analyzed risk factors for postprocedural @entity788 . RESULTS: CBD stones were removed successfully in 107 of 109 @entity1 (98.1%) in the 20-second group and in 112 of 119 @entity1 (94.1%) in the 60-second group (p=0.146). Post-ERCP @entity788 developed in seven @entity1 (6.4%) in the 20-second group and nine @entity1 (7.5%) in the 60-second group (p=0.408). In multivariate analysis, contrast dye injection into the pancreatic duct is a significant risk factor for post-EPBD @entity788 . CONCLUSIONS: Based on the data showing that there were no significant differences in safety and efficacy between the two @entity384 groups, 20 seconds of @entity384 may be adequate for treatment of small CBD stones with EPBD.
