Noninvasive cerebrovascular autoregulation assessment in XXXX : validation and utility.

@entity1 @entity131 @entity428 @entity1337 @entity8547 @entity551 @entity1779
A moving correlation index (Mx-CPP) of cerebral perfusion pressure (CPP) and mean middle cerebral artery blood flow velocity (CBFV) allows continuous monitoring of dynamic @entity1779 ( @entity1779 ) in @entity1 with severe @entity131 ( @entity131 ). In this study we validated Mx-CPP for @entity131 , examined its prognostic relevance, and assessed its relationship with @entity551 ( @entity551 ), CPP, @entity428 ( @entity428 ), and CBFV. We tested whether using @entity551 instead of CPP for Mx calculation (Mx- @entity551 ) produces similar results. Mx was calculated for each hemisphere in 37 @entity131 @entity1 during the first 5 days of treatment. All @entity1 received sedation and @entity1337 . CPP and bilateral CBFV were recorded, and GOS was estimated at discharge. Both Mx indices were calculated from 10,000 data points sampled at 57.4Hz. Mx-CPP > 0.3 indicates impaired @entity1779 ; in these @entity1 CPP had a significant positive correlation with CBFV, confirming failure of @entity1779 , while in those with Mx < 0.3, CPP was not correlated with CBFV, indicating intact @entity1779 . These findings were confirmed for Mx- @entity551 . We found a significant correlation between impaired @entity1779 , indicated by Mx- @entity8547 and Mx- @entity551 , and poor outcome for @entity131 @entity1 . @entity551 , CPP, @entity428 , and CBFV were not correlated with @entity1779 but it must be noted that our average CPP was considerably higher than in other studies. This study confirms the validity of this index to demonstrate @entity1779 preservation or failure in @entity131 . This index is also valid if @entity551 is used instead of CPP, which eliminates the need for @entity428 for @entity1779 assessment. An unfavorable outcome is associated with early @entity1779 failure. Further studies using the Mx- @entity551 will reveal whether @entity1779 improves along with @entity1 ' clinical improvement.
