Elevated Serum MicroRNA XXXX in Moyamoya Disease.

@entity1 @entity8731 @entity7025 @entity792 @entity1779 @entity10075 @entity385
BACKGROUND: Few studies have examined the relationship between mircroRNAs and @entity7025 ( @entity7025 ). We performed a study of the significance of @entity10075 expression in the serum of @entity7025 @entity1 . METHODS: The experimental group includes 49 @entity7025 @entity1 , and the control group consists of 30 normal @entity1 , 20 @entity1779 @entity1 , 20 massive @entity385 @entity1 , 20 nonmassive @entity385 @entity1 , and 20 neurological @entity792 @entity1 . Let-7 family levels were determined by polymerase chain reaction. A dual luciferase assay was used to test whether @entity10075 recognized the 3'UTR of @entity8731 . RESULTS: The expression level of @entity10075 in @entity7025 @entity1 is higher than that observed in the control groups (P  <  .001). The luciferase assay results indicated that @entity10075 could diminish luciferase activity from a reporter vector containing the 3'-UTR of @entity8731 (P  <  .05). The suppression of luciferase activity is not found in mutRNF213 (P  >  .05). CONCLUSIONS: Increased expression of @entity10075 in @entity7025 @entity1 may contribute to @entity7025 pathogenesis by targeting @entity8731 . Thus, @entity10075 may be a potential biomarker for the diagnosis of @entity7025 .
