Impact of 18F-Choline PET/CT in the Decision-Making Strategy of Treatment Volumes in Definitive XXXX Volumetric Modulated Radiation Therapy.

@entity1 @entity5 @entity263 @entity342
INTRODUCTION: Aim of the study is to evaluate the impact of Cho-PET/CT in decision-making strategy of @entity1 with @entity263 (PC) eligible to definitive radiotherapy (RT). MATERIALS AND METHODS: Sixty @entity1 Cho-PET/CT before RT were prospectively enrolled. All @entity1 were treated with volumetric modulated arc therapy with simultaneous integrated boost in 28 fractions. @entity342 deprivation therapy was prescribed according to National @entity5 Network (NCCN) risk classification. Therapeutic strategy based on the Cho-PET/CT evaluation was compared with the strategy that would have been proposed in case of PET not available and/or not strictly indicated, according to international and national PC guidelines. RESULTS: Cho-PET/CT was positive in 57 cases (95%): T in 45 (79%); T in combination with N in 8 (14%); and M (bone) in combination with T or N, or both, in 4 (7%). After Cho-PET/CT, @entity1 were stratified as follows: 26 (43%) low risk, 10 (16%) intermediate risk, and 24 (41%) high risk. Cho-PET/CT shifted treatment indication in 13 cases (21%). The changes regarding radiation treatment volumes were as follows: 6 intermediate risk (10%) shifted to high risk and consequently were irradiated on prostate, seminal vesicles, and pelvic nodes PTVs; in 7 high risk (11%), the Cho-PET/CT showed bone and/or N uptake, and consequently, a simultaneous integrated boost on PET positive sites was prescribed. CONCLUSIONS: Cho-PET/CT seems to be a promising diagnostic tool in @entity1 who are candidates for radical RT and supporting the decision making in treatment planning, in particular in intermediate-high risk.
