MR imaging of acute experimental ischemia in XXXX .

@entity468 @entity1188 @entity2806 @entity548
The evolution of @entity2806 was documented by magnetic resonance (MR) imaging in 13 mongrel @entity468 with occlusion of the middle cerebral artery through a transorbital approach. The animals were imaged under anesthesia at intervals from 30 min to 10 days after production of the lesion. An MR imager operating at 0.35 T was used with multislice, multi-spin-echo technique (TR = 500-2000 msec; TE = 28, 56 msec). The animals were sacrificed after imaging for pathologic correlation. @entity1188 beyond 4 hr of age were visualized in all subjects. The earliest @entity1188 was seen at 30 min (two @entity468 ) as an area of high signal intensity on T2-weighted images. In three other @entity468 , however, 3-hr-old @entity1188 were not detectable. In one animal, a @entity548 within a 1-week-old area of @entity1188 was not characterized by MR imaging but was identified on CT scanning. The mass effect of the @entity1188 appeared greatest at 2-4 days after @entity1188 . The basal ganglia showed ischemic effects to best advantage. MR imaging offers previously unavailable sensitivity for the early noninvasive detection of @entity2806 in vivo.
