Placental growth factor 2 - A potential therapeutic strategy for chronic XXXX .

@entity1 @entity1707 @entity296 @entity452 @entity64 @entity63 @entity450 @entity741 @entity72485
OBJECTIVES: We investigated whether sustained infusion of recombinant @entity1 placental growth factor-2 (rhPlGF-2) improves myocardial perfusion and left ventricular (LV) function in a porcine model of @entity296 ( @entity296 ). METHODS: We induced @entity741 using a flow-limiting stent in the LAD. Four weeks later, we randomized @entity1707 with confirmed @entity296 to blinded rhPlGF-2 administration (PlGF2, 15 g/kg/day, 14days) or PBS (CON). At 8weeks, we measured hemodynamics, contractile function and regional perfusion at rest and during stress using MRI and microspheres. We evaluated neovascularization post mortem. RESULTS: RhPlGF-2 administration increased @entity72485 serum levels more than 63-fold (833  361 versus 11  5pg/ml CON, P<0.05) without adverse effects. After 4weeks, rhPlGF-2 significantly enhanced perfusion in the @entity63 region at rest (0.83  0.32 versus 0.58  0.21ml/min/g CON, P<0.05) and during @entity450 (1.50  0.50 versus 1.02  0.46ml/min/g CON, P<0.05). Consequently, regional contractile function in rhPlGF-2-treated @entity1707 improved at rest (37  15% versus 23  9% CON, P<0.05) and during high dose @entity452 stress (53  31% versus 27  16% CON, P<0.05). Enhanced perfusion translated into a greater improvement in LV ejection fraction and in preload-recruitable @entity64 work in rhPlGF-2-treated animals than in CON (52  11 versus 41  9%, and 76  24 versus 41  21mmHg, respectively, P<0.05 for both), which was associated with significantly greater vascular density in the @entity63 region. CONCLUSIONS: In chronic @entity296 , systemic rhPlGF-2 administration significantly enhances regional myocardial perfusion, contractile function at rest and during stress, and induces a prominent recovery of global cardiac function. @entity72485 -2 protein infusion is safe and may represent a promising therapy in chronic @entity296 .
