Pathological response of cavernous XXXX following radiosurgery.

@entity1 @entity455 @entity548 @entity2295 @entity3808 @entity600 @entity1463
UNASSIGNED: OBJECT Stereotactic radiosurgery (SRS) is a therapeutic option for repeatedly hemorrhagic cavernous @entity600 (CMs) located in areas deemed to be high risk for resection. During the latency period of 2 or more years after SRS, recurrent @entity548 remains a persistent risk until the obliterative process has finished. The pathological response to SRS has been studied in relatively few @entity1 . The authors of the present study aimed to gain insight into the effect of SRS on CM and to propose possible mechanisms leading to recurrent @entity548 following SRS. METHODS During a 13-year interval between 2001 and 2013, @entity548 recurred in 9 @entity1 with CMs that had been treated using Gamma Knife surgery at the authors' institution. Microsurgical removal was subsequently performed in 5 of these @entity1 , who had recurrent @entity548 between 4 months and 7 years after SRS. Specimens from 4 @entity1 were available for analysis and used for this report. RESULTS Histopathological analysis demonstrated that @entity455 develops as early as 4 months after SRS. In the samples from 2 to 7 years after SRS, @entity3808 vessels were prominent, but there were also vessels with @entity1463 as well as some foci of @entity2295 . CONCLUSIONS Recurrent @entity548 after SRS for CM could be related to @entity1463 of the vessels, but @entity2295 may also play a role.
