Abnormalities of some phagocyte membrane receptors during XXXX .

@entity1 @entity55 @entity19 @entity3584 @entity580 @entity224
The frequent and severe @entity580 in ICU @entity1 suggest that these @entity1 are immunodeficient. We studied the phagocytic activity of granulocytes and monocytes isolated from the blood of 32 ICU @entity1 with @entity55 (19 male, 13 female; age @entity19 yr). Cells were tested in standard medium and in the presence of patients' serum. Blood granulocytes and monocytes were purified and separately exposed to opsonized zymosan (to test C3 receptor function), immunoglobulin-coated erythrocytes (to test Fc receptor function), and @entity3584 -treated erythrocytes (to test nonspecific binding structures). Phagocytosis and @entity224 anion production were measured. Granulocytes of @entity1 exhibited a substantial decrease of zymosan ingestion (p less than .05), whereas phagocytosis of other particles was normal. Monocytes from the @entity1 displayed an unselective overall decrease of phagocytic ability for the three particle types (p less than .05). @entity1 ' sera were at least as efficient as a pool of normal sera in opsonizing zymosan. Further, no phagocytic inhibitor was found in the tested @entity1 . In conclusion, we point out a deficiency of membrane receptors of neutrophils and monocytes in ICU @entity1 with @entity580 .
