Expression profiling reveals that methylation of XXXX is involved in @entity2184 development.

@entity1 @entity8111 @entity5 @entity2184 @entity3 @entity320 @entity11508
@entity2184 is associated with a high @entity5 -related mortality due to the propensity to develop @entity3 . The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of @entity3 . To identify molecules involved in dissemination, we used cell lines derived from a primary @entity2184 and 2 liver @entity3 from the same @entity1 as a model for @entity5 progression. Using a microarray representing 1,176 genes, we identified 63 differentially expressed genes. Forty genes showed a higher expression and 23 showed a lower expression in the primary cell line compared to the @entity3 cell lines. These genes are involved in processes like angiogenesis, apoptosis, macrophage stimulation, and extracellular matrix regulation. In contrast, the 2 liver @entity3 cell lines produced nearly identical expression profiles. Demethylation of the primary @entity320 cell line by @entity11508 treatment revealed that 19 genes were suppressed by hypermethylation. An important finding was the 5-fold decreased expression of @entity8111 in the metastatic cell lines, a molecule involved in extracellular matrix degradation. We demonstrate in the cell lines that @entity8111 expression is regulated by methylation. These observations were confirmed in primary @entity2184 and suggests a role for @entity8111 in @entity2184 development.
