In-vitro hypocoagulability on whole blood thromboelastometry associated with in-vivo expansion of @entity4085 in an XXXX model.

@entity1 @entity6582 @entity1641 @entity4085 @entity2647
In several species, there is a strong correlation between indicators of @entity4085 ( @entity4085 ) and thromboelastometry results. The @entity1641 has a reliable, temporary, @entity6582 in response to @entity2647 infusion. Our objective was to evaluate the effects of an in-vivo increase in circulating @entity4085 on thromboelastometry results in an @entity1641 model of transient @entity6582 . Six healthy research @entity1641 had whole blood thromboelastometry with contact activator and tissue factor initiation after recalcification of citrated samples. Additional samples were frozen for thrombin-antithrombin (TAT). Complete blood count biochemical analysis, fibrinogen, activated partial thromboplastin time (aPTT), and prothrombin time (PT) were performed. Additional samples were taken at 5 min and 2 h after @entity2647 infusion. Thromboelastometry was performed separately on four @entity1641 not receiving @entity2647 with the samples divided and spiked with @entity2647 ex vivo. Red cell count (P<0.001) and hematocrit (P<0.001) were significantly higher at 5 min after @entity2647 compared with baseline and 2 h. There was no change in platelet count, fibrinogen, PT, aPTT, or TAT at any time point. Both ex-tem and in-tem parameters were hypocoagulable at 5 min after @entity2647 compared to baseline and 2 h. There was no effect of @entity2647 in the ex-vivo spiking studies on any of the thromboelastometry parameters. Whole blood thromboelastometry results were hypocoagulable in this @entity1641 model of in-vivo transient @entity6582 only during the polycythemic phase. All other coagulation parameters were unchanged. In the absence of other indicators of hypocoagulability, this may point to an artifact of thromboelastometry. Alternatively, the data may reflect true in-vivo hypocoagulability in @entity1 with increased circulating @entity4085 .
