Association of single nucleotide polymorphism XXXX in @entity22400 gene with @entity1669 in a Chinese Han population.

@entity71253 @entity2743 @entity1669 @entity2621 @entity30 @entity22400 @entity792 @entity309
BACKGROUND: The @entity1669 ( @entity1669 ), including @entity2743 ( @entity2743 ) and @entity2621 ( @entity2621 ), are caused by interactions between susceptibility genes and environmental triggers. Single nucleotide polymorphisms (SNPs) of Solute carrier family 22, member 4 ( @entity22400 ) have been shown to be associated with several @entity792 , including @entity30 ( @entity30 ) and @entity309 ( @entity309 ). The aim of this study is to investigate whether SNP @entity71253 in the @entity22400 gene is associated with @entity2743 , @entity2621 and @entity1669 in a Chinese Han population. METHODS: In this study, we collected specimens from 553 Chinese Han individuals of 92 @entity1669 pedigrees in 10 cities in Liaoning province, China (80 @entity2743 pedigrees, 478 members; 12 @entity2621 pedigrees, 75 members). SNP @entity71253 was genotyped using the TaqMan allelic discrimination assay. Hardy-Weinberg Equilibrium tests were performed among founders of the pedigrees using Haploview software. Family-based association tests performed using FBAT software. RESULTS: No deviation from Hardy-Weinberg equilibrium was observed (p   >   0.05). There were not significant association between the @entity22400 gene polymorphism ( @entity71253 ) and @entity2743 , @entity2621 and @entity1669 was found. CONCLUSIONS: These results suggest a lack of association between the @entity22400 gene polymorphism @entity71253 and susceptibility to @entity2743 , @entity2621 and @entity1669 in a Chinese Han population.
