Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in XXXX .

@entity2835 @entity35 @entity13358 @entity1918 @entity1810 @entity1575
BACKGROUND: @entity1575 is a @entity1575 , and nodule formation. The @entity1810 ( @entity1810 ) and @entity13358 ( @entity13358 ) are very important cytokines in hepatic fibrogenesis. The aim of this study was to examine the relationship between the changes of the serum cytokines and morphological changes following common bile duct ligation in experimental @entity35 . METHODS: Common bile ducts of fifty male @entity35 were ligated and seven male @entity35 were set aside as controls. Five @entity35 each were sacrificed in 1, 2, 4, 6, 8, and 10 experimental weeks. Light microscopic studies and liver function tests were performed during the above experimental weeks. The levels of serum @entity1810 and @entity13358 were analyzed by ELISA. Also, @entity1918 ( @entity1918 ) immunohistochemical stains were performed. RESULTS: On the eighth week after common bile duct ligation, most hepatic lobular areas had been replaced by proliferated bile ducts and fibrous tissue (typical @entity2835 ). Serum @entity1810 levels between the control group and the common bile duct ligation group showed statistically significant changes. The @entity1918 was stained at proliferated bile ducts. These findings were correlated with each other. CONCLUSION: Thus, this experiment may clarify our understanding of the mechanism in liver fibrogenesis. Also, indicated is a need to explore the therapeutic potential of these cytokines as anti-fibrotic agents.
