3b-O-Tigloylmelianol from Guarea kunthiana: A New Potential Agent to Control Rhipicephalus (Boophilus) microplus, a XXXX Tick of Veterinary Significance.

@entity4315 @entity291 @entity71959 @entity1044 @entity71958 @entity1068
Chemical investigation of Guarea kunthiana fruits, guided by their effect on the reproductive cycle of engorged females of the @entity291 tick Rhipicephalus (Boophilus) microplus-a major economic problem to the livestock industry worldwide-led to isolation of 3b-O-tigloylmelianol, a new protolimonoid, from the bioactive @entity4315 phase obtained by partitioning the crude @entity1068 extract. An adult immersion test was performed. The compound strongly inhibited egg-laying and hatchability (99.2% effectiveness at a 0.01% concentration). @entity71958 , isolated from the same phase, yielded unremarkable results in the adult immersion test. From the @entity1044 phase, melianol, @entity71959 , meliantriol, and a new protolimonoid, 3b-O-tigloylmeliantriol, were isolated, all of which, in the same manner as @entity71958 , exhibited unremarkable results in the test. The structures of new and known compounds were mostly established by 1D- and 2D-NMR analyses and mass spectrometry data. This is the first report on the bioactivity of protolimonoids on the reproductive cycle of engorged females of R. (B.) microplus. 3b-O-Tigloylmelianol proved a promising candidate for the development of a biocontrol agent against the @entity291 tick investigated, as an alternative to environmentally hazardous synthetic acaricides.
