Quality of life in XXXX with @entity1374 . A review.

@entity1 @entity73 @entity283 @entity1374
The importance of @entity1 -reported outcomes such as @entity283 ( @entity283 ) in clinical research is increasingly acknowledged. In order to yield valid results, the measurement properties of @entity283 questionnaires must be thoroughly investigated. One aspect of such a validation process is the demonstration of content validity, i.e. that the questionnaire covers all relevant aspects. We review studies reporting on consequences of @entity1374 and present the frequency of identified aspects, both overall @entity283 issues and classical thyroid symptoms, in order to evaluate which issues are relevant for @entity1 with @entity1374 . Furthermore, existing questionnaires for thyroid @entity1 are reviewed. A systematic search was performed in the Medline, Cinahl and Psycinfo databases and the reference lists of the relevant articles were hand-searched. Seventy-five relevant studies were identified. According to these studies, @entity1 with untreated @entity1374 suffer from a wide range of symptoms and have @entity73 in most areas of @entity283 . Furthermore, the studies indicate that impairments in @entity283 are also frequent in the long term. Six @entity283 questionnaires for thyroid @entity1 were identified. Generally, data supporting the validity of these questionnaires were sparse. According to the available literature, the quality of life of thyroid @entity1 is substantially impaired over a wide range of aspects of @entity283 in the untreated phase and continues to be so in many @entity1 also in the long term. Studies systematically exploring the relative importance of these various aspects to thyroid @entity1 are lacking, as is a comprehensive, validated thyroid-specific @entity283 questionnaire.
