Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two XXXX strains.

@entity101 @entity6 @entity1674 @entity1808 @entity3407 @entity1670 @entity9886 @entity1011 @entity35 @entity12360 @entity413 @entity165
Maitake mushroom has been reported to favorably influence @entity101 and @entity6 . The purpose of this study was to compare the effects of whole Maitake mushroom powder and two extracts designated as ether soluble (ES) and @entity12360 ( @entity12360 ) on Zucker fatty @entity35 (ZFR), a model of insulin resistance, and on spontaneously @entity101 @entity35 (SHR), a model of @entity101 . In the initial study, we followed four groups of eight ZFR and SHR receiving special diets: a baseline diet (BD), BD + whole Maitake mushroom powder (20% w/w), BD + fraction ES (0.10% w/w), and BD + @entity12360 (0.22% w/w). Different effects of these dietary regimens on the 2 @entity35 strains were found. At 35 days, only consumption of the ES diet significantly decreased systolic BP (SBP) in SHR (average 197 vs. 176 mm Hg, p < 0.001), while in ZFR only the groups consuming the whole Maitake and @entity12360 diets showed significantly decreased SBP (138 vs. 120-125 mm Hg, p < 0.001). A challenge test with @entity9886 (an @entity1808 receptor blocker) indicates that @entity1808 does not play a major role in SBP regulation of ZFR, but does in SHR where consumption of ES relative to other groups significantly lowered activity of this system. In SHR, @entity413 , @entity165 , circulating insulin and HbA1C were virtually similar among all dietary groups; but whole Maitake (-22%), ES (-120%) and @entity12360 (-80%) diets were associated with decreased @entity1674 , and the ES diet with lowered serum @entity1011 (-29%). In ZFR, circulating insulin and HbA1C were significantly decreased in the whole Maitake powder and ES groups, and tended to be lower in the @entity12360 group compared to control. In the ensuing studies, we gavaged ZFR once daily with water (control), 44 mg fraction @entity12360 , or 44 mg fraction @entity12360 plus 100 microg @entity1670 -bound @entity3407 (NBC). Oral gavage of @entity12360 clearly lowered SBP and circulating @entity413 concentrations, more so with the addition of @entity3407 . We conclude that the examined forms of Maitake mushroom have antihypertensive and antidiabetic potential which differ among @entity35 strains. The ES fraction may decrease SBP in SHR via alteration in the renin-angiotensin system.
