Short-term Intravenous Antibiotic Treatment in Uncomplicated XXXX Does Not Increase the Risk of Recurrence Compared to Long-term Treatment.

@entity1 @entity2756 @entity868 @entity4436
PURPOSE: This study included all @entity1 treated at the University Hospital of Geneva for a first episode of uncomplicated @entity4436 . Risks of recurrence and treatment failure were evaluated by comparing the results between short-course and long-course intravenous (IV) antibiotic therapy groups. METHODS: The records of all @entity1 hospitalized at our facility from January 2007 to February 2012 for a first episode of uncomplicated @entity4436 (Hinchey Ia), as confirmed by computed tomography, were prospectively collected. We published an auxiliary analysis from this registered study at Clinicaltrials.gov (identifier number: NCT01015378). Two groups of @entity1 were considered: one received a short-course IV antibiotic arm ( @entity2756 and @entity868 ) for up to 5 days (followed by 5 days of oral antibiotics); the other received a long-course IV arm between days 5 and 10. The primary outcome was the recurrence-free survival time. RESULTS: Follow-up was completed for 256 @entity1 -50% @entity1 and 50% @entity1 , with a median age of 56 years (range, 24-85 years). The average follow-up was 50 months (range, 19-89 months). Of the 256 @entity1 included in the study, 46 @entity1 received a short-course IV antibiotic treatment and 210 received a long-course treatment. The recurrence-free survivals were very similar between the two groups, which was supported by a log rank test (P = 0.772). Four treatment failures, all in the long-course IV antibiotic treatment group, occurred. CONCLUSION: Treatment of @entity4436 with a short IV antibiotic treatment is possible and does not modify the recurrence rate in @entity1 with uncomplicated @entity4436 .
