Daily activities: exploring their spectrum and prognostic impact in older, chemotherapy-treated XXXX @entity1 .

@entity1 @entity137 @entity5 @entity3003 @entity1149 @entity2 @entity1311
BACKGROUND: Performance scores predict benefits and @entity137 from chemotherapy. Among older @entity5 @entity1 , however, many investigators have empirically called for a detailed assessment of activities of daily living, claiming that the utility of performance scores is limited in this older population. This study's goals were therefore twofold: (1). to explore the predictive capability of an activities questionnaire and of performance score with respect to chemotherapy's @entity137 and efficacy; (2). to describe the daily activities of older @entity1 as they undergo chemotherapy for incurable metastatic @entity2 . METHODS: As part of a multi-institutional therapeutic trial, this study included 48 @entity1 >or=65 years of age with metastatic @entity1149 . All were assigned an Eastern Cooperative Oncology Group (ECOG) performance score and completed an activity questionnaire (Voorrips) prior to the initiation of @entity3003 and @entity1311 . @entity1 were monitored for @entity137 (CTC, version 2) and @entity5 status. RESULTS: Within this cohort, ECOG performance scores were poor at predicting grade 3 or worse toxic events ( P=0.71, Mantel-Haenszel chi-squared). In contrast, the activity questionnaire categories did predict grade 3 or worse @entity137 ( P=0.03) with a positive association observed between greater levels of activity and lower @entity137 rates. Neither instrument predicted 90-day disease progression, although there was a trend that suggested a positive association between favorable scores and lower progression rates ( P=0.051). @entity1 described a broad range of daily activities. CONCLUSION: Activity questionnaires capture a broad range of data that may prove useful in predicting @entity137 among older @entity5 @entity1 .
