Plasma total and unacylated ghrelin predict 5-year changes in XXXX resistance.

@entity209 @entity1 @entity2690 @entity348
BACKGROUND _ AIMS: Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UG) forms, and higher plasma @entity348 ( @entity348 ) and UG may be cross-sectionally associated with lower @entity2690 resistance in @entity209 @entity1 . The potential value of ghrelin forms in predicting @entity2690 resistance and its time-related changes in community-based population cohorts remains unknown. METHODS: We measured @entity348 , AG and calculated UG ( @entity348 -AG) in 716 individuals from the North-East-Italy MoMa study (age: 55      9 years, BMI: 29      5  kg/m(2), M/F:349/367) to test the hypothesis that circulating @entity348 and UG, but not AG are negatively associated with @entity2690 resistance (HOMA). We further hypothesized that baseline @entity348 and UG negatively predict 5-year HOMA changes in a 350-individual subgroup. RESULTS: Baseline @entity348 and UG were associated negatively with HOMA after adjusting for gender and body mass index (BMI). Baseline gender- and BMI-adjusted @entity348 and UG were also negatively associated with HOMA at 5-year follow-up (n  =  350), and changes in @entity348 and UG were negatively associated with changes in HOMA (P  <  0.05) after adjustment for anthropometric and metabolic confounders. No statistically significant correlations were observed between AG and baseline or 5-year HOMA. CONCLUSIONS: In a North-East Italy community-based population cohort, plasma @entity348 and UG but not AG are negatively associated with HOMA. @entity348 and UG and their changes also independently predict 5-year HOMA changes. @entity348 and UG are therefore novel potential modulators of @entity2690 resistance and may contribute to predict its time-related changes in @entity1 .
