Surgical outcome of abdominoperineal resection for XXXX in a Nigerian tertiary institution.

@entity5 @entity1 @entity190
BACKGROUND: @entity5 is a lifestyle-related illness with an increasing incidence in all developing countries in the last decade. Abdominoperineal resection (APR) offers a good oncologic clearance for @entity5 . The remaining controversies surrounding APR, as it is performed in a tertiary center in Nigeria, involve defining the role the operation plays in the management of existing rectal problems and determining what outcomes can be expected. The present study was aimed at examining the surgical outcomes of APR for @entity5 in a Nigerian tertiary institution. MATERIALS AND METHODS: This single-institution, retrospective, descriptive study analyzed APR rate, @entity1 sex and age, subsite involvement, the diagnostic process, follow-up, and survival patterns after treatment of @entity5 . The study was conducted at Obafemi Awolowo University Teaching Hospital Complex Ile-Ife, Nigeria, between January 1989 and December 2007. RESULTS: During the 18-year period, 36 @entity1 underwent APR. This accounts for 24.0% of all @entity1 that had @entity5 . The age of the @entity1 ranged from 29 years to 74 years (median: 58.9 years). Most of the @entity1 were 60 years of age or older, and the majority were @entity1 (55.9%). The median duration of symptoms was 12 months, and all @entity1 sought medical care for bleeding per rectum. Close to 80% of @entity1 had advanced disease at presentation. Postoperatively, 17 @entity1 (50%) had at least one complication and one @entity1 (2.9%) died. Four (11.8%) @entity1 had recurrence of the @entity5 , and in every case, recurrence occurred within the first year after operation. Operative @entity190 (p = 0.006), degree of differentiation of the @entity5 (p = 0.011), distance from the anal verge (p = 0.033), and operative stage (p = 0.005) were found to significantly affect the outcome of treatment for the @entity1 who underwent APR. The operative stage similarly affected the survival of @entity1 (Mantel Cox = 0.026). CONCLUSIONS: Despite the advanced disease of our @entity1 , the outcome of management appears to be comparable with results reported from other centers.
