XXXX -responsive cells of dorsal root ganglia in culture: cell size, firing, cytosolic calcium, and @entity10501 .

@entity19 @entity593 @entity10501 @entity1812 @entity141
1. We analyze @entity1812 -sensitive cells of the @entity19 dorsal root ganglion in culture from the viewpoints of cell size, electrical responses, and @entity141 concentration change due to @entity1812 and immunocytochemistry of @entity10501 . 2. Sixteen percent of cells in the cell group 26-30 microns in diameter fired in response to 10 microM @entity1812 . None of other cell groups showed a firing response to @entity1812 . 3. We measured a cytosolic @entity141 change due to @entity1812 using a @entity141 -sensitive fluorescent dye, @entity593 . The rapid rise (peak time, 20 sec) in the @entity141 concentration was ascribed to @entity141 release from intracellular @entity141 stores. The profound change in the @entity141 concentration was observed again in the cell group 26-30 microns in diameter. Seventeen percent of cells in this group increased the @entity141 concentration by approximately seven times that at resting level. 4. Among cells which increase @entity141 concentration responding to @entity1812 , 83% of them contain @entity10501 (an immunocytochemical study). 5. We conclude that 16-17% of the cell group 26-30 microns in diameter of the dorsal root ganglia in culture are polymodal nociceptors and respond to @entity1812 .
