Distinct perturbations of @entity957 XXXX : A quantitative cytomorphometric analysis.

@entity1 @entity286 @entity5 @entity957 @entity204
OBJECTIVE: @entity5 constitutes a major health issue in developing countries, representing the leading cause of @entity204 . Quantitative assessment by sophisticated diagnostic techniques is becoming increasingly important. Hence, a histochemical staining procedure and morphometric evaluation are used to obtain optimal information on the cellular events. The objective of present study is to assess the variation in cellular area, nuclear area, cellular diameter, nuclear diameter and nuclear/cytoplasmic ratio respectively in normal subjects, smokeless @entity286 users, (smokers, combination and @entity957 @entity1 . METHODS: Total 125 number of subjects were divided into five groups, each comprising 25 subjects of more than 40 years of age. These groups were: a. Normal, b. smokeless @entity286 users, c. smokers d. combination and e. @entity957 . Oral smears were obtained, stained with Feulgen stain and the cells were measured cytomorphometrically using Nikon imaging software. RESULTS: Our study showed a significant reduction in the cellular diameter, cellular area and increase in the nuclear diameter, nuclear area and nuclear/cytoplasmic ratio in @entity957 @entity1 as compared to @entity286 users and normal @entity1 . Significant changes were found in group I, II, III and IV when compared with group V but as such no significant intergroup variation was found in cellular and nuclear dimensions in smokers, smokeless @entity286 users, combination and control group. CONCLUSION: Quantitative parameters could be assessed by cytomorphometry. Cytomorphological changes in exfoliated squames could serve as a useful adjunct in the early diagnosis of @entity957 .
