XXXX determined by flow cytometric analysis.

@entity981 @entity0 @entity2667 @entity5 @entity189
Eight cases of primary @entity0 were studied for evidence of heterogeneity by flow cytometry using @entity2667 staining of DNA. @entity5 ranged from 2.5 to 8.0 cm in greatest dimension, mean 4.2 cm. Five to 11 samples, determined by @entity5 size, were analyzed from each primary @entity5 in addition to 4 axillary lymph nodal metastases from 3 of the 8 cases. The presence of @entity189 was demonstrated histologically in each flow cytometric sample. Three of the @entity189 showed only diploid DNA content. Three showed the same single @entity981 population in each sample. Two @entity189 (2.5 and 3.5 cm) were heterogeneous and demonstrated 2 or 3 @entity981 populations. The 2 or 3 distinct @entity981 populations were present singly or sometimes in combination in one sample. Five of the 11 samples from 1 of the heterogeneous @entity5 and its axillary metastasis contained a single diploid population. Therefore, flow cytometric analysis of a single sample from a @entity0 may not be representative of the entire @entity5 . The study of multiple samples of @entity0 by flow cytometry is necessary for full characterization of the @entity5 .
