NF-kB transcriptional inhibition ameliorates @entity900 -induced XXXX ( @entity810 ).

@entity32 @entity563 @entity4295 @entity19 @entity1750 @entity900 @entity1618 @entity15891 @entity810 @entity72552 @entity13761 @entity10873 @entity72553 @entity637 @entity72551 @entity1889
UNASSIGNED: The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) cell signaling pathway is important in @entity32 and cell survival. @entity32 and cell death in the kidney are features of @entity900 -induced @entity810 . While it is known that @entity900 induces NF-kB signaling in the kidney, the NF-kB responsive genes and the effect of direct NF-kB transcriptional inhibition in @entity900 -induced @entity810 is not known. @entity19 injected with @entity900 , 25mg/kg, developed @entity810 , @entity4295 ( @entity4295 ) and apoptosis on day 3. @entity19 were treated with @entity72551 (20 or 40mg/kg) which directly affects NF-kB transcriptional activity. Kidney function, @entity810 ( @entity4295 , serum neutrophil gelatinase-associated lipocalin [NGAL], but not apoptosis) and @entity10873 ( @entity10873 ) activity were significantly improved by @entity72551 (40mg/kg). Sixty one NF-kB responsive genes were increased by @entity900 of which 21 genes were decreased by @entity72551 . Genes that were decreased by @entity72551 that are known to play a role in @entity900 -induced @entity810 were @entity1618 , IFN-y, chemokine [C-C motif] ligand 2 ( @entity1750 ) and @entity13761 . Another gene, caspase recruitment domain family, member 11 ( @entity72552 ), not previously known to play a role in @entity810 , was increased more than 20-fold and completely inhibited by @entity72551 . @entity15891 and @entity637 , known mediators of @entity900 -induced @entity810 , were decreased by @entity72551 . @entity72553 , receptor-interacting @entity563 / @entity1889 -protein kinases, that play an important role in necroptosis, were decreased by @entity72551 . In @entity19 proximal tubule cells in culture, @entity72551 resulted in an increase in apoptosis suggesting that the mechanism of protection against @entity810 by @entity72551 is not due to a direct effect on proximal tubules. In conclusion, NF-kB transcriptional inhibition in @entity900 -induced @entity810 without a significant effect on apoptosis and is associated with a decrease pro-inflammatory mediators and @entity72552 .
