XXXX Nanoparticles for Therapeutic Angiogenesis.

@entity12698 @entity712 @entity5532 @entity63 @entity5 @entity19 @entity544 @entity583
UNASSIGNED: Controllable induction of blood vessel formation (angiogenesis) presents an important therapeutic goal in @entity63 and is also beneficial in various normal physiological processes. In this study, we have shown that nanoparticles of @entity12698 , a lipophilic nonsteroidal anti-inflammatory drug, effectively evoke therapeutic angiogenesis in animal models, in both normal and @entity63 organs. @entity12698 is widely considered to inhibit angiogenesis, although a recent study suggests that it can instead promote blood vessel growth in @entity5 cell lines. The hydrophobic nature of this drug necessitates its administration in nanoparticulate form in order to elicit a perceivable pharmacological response. We developed a facile method for nanoparticle formation by solvent extraction from microemulsions in supercritical @entity544 . This method exploits a spontaneous formation of nanometric domains within the microemulsion system and their rapid conversion to nanoparticles by supercritical fluid. The resultant nanoparticles were administered subcutaneously to @entity19 in a biocompatible hydrogel, and caused a 4-fold increase in blood vessel count in normally perfused skin compared with drug-free particles. They were at least as effective in inducing angiogenesis as nanoparticles of @entity5532 , a well-established neovascularization promoter. Next, we evaluated their effect on @entity63 tissues in @entity19 model of @entity583 . We found that @entity12698 nanoparticles were able to induce a significant vascularization of @entity63 myocardium and hamper the progression of @entity712 , which points toward a new approach for treating @entity63 .
