Secretion and dynamics of herpes simplex virus in tears and saliva of XXXX with @entity4401 .

@entity1 @entity3307 @entity3141 @entity4401
OBJECTIVE: For clarification of the direct relationship between the reactivation of herpes simplex virus and the development of @entity4401 , a detection of the virus genome by @entity3141 diagnostics and a quantitative analysis of its time-course change are both needed. The authors detected the HSV genome in specimens from @entity1 with @entity4401 , quantified its number of copies, and examined time-course changes. SUBJECTS AND METHODS: The subjects were 16 @entity1 with @entity4401 . The tear fluid and saliva from the submandibular gland and the parotid gland were separately collected from the affected and unaffected sides twice or more. A total of 244 specimens were subjected to extraction of @entity3141 , polymerase chain reaction, and microplate hybridization. RESULTS: @entity3307 @entity3141 was detected in 38 specimens (11.8%) from 5 @entity1 (31%). The high detection (28.5%) was obtained within 2 weeks after onset. Detection at 3 weeks and later (2.8%) was significantly lower ( < 0.05). In three cases, @entity3141 was also found on the unaffected side in the initial phase of the disease, but detection on that side (18.9%) was significantly lower than on the affected side (83.8%) ( < 0.01). The number of copies of the @entity3307 genome was large on the affected side and early after the onset of the disease. CONCLUSIONS: The reactivation of @entity3307 on the affected side is involved as a pathogenic factor of @entity4401 . A reactivation of @entity3307 may be generated even on the unaffected side in the early phase of the disease. Herpes simplex virus @entity3141 was not detected in any of the examined specimens collected from the remaining 11 cases. The need for constant study to clarify other causative factors of @entity4401 remains.
