[Effects of sex hormones on bladder function and structure: experiment with ovariectomized female XXXX ].

@entity172 @entity3033 @entity251 @entity1420 @entity1494 @entity1184 @entity4520 @entity342 @entity35
OBJECTIVE: To investigate the effects of sex hormones on bladder and mechanism thereof. METHODS: Sixty mature female SD @entity35 underwent bilateral ovariectomy and then randomly divided into 6 groups: low dose @entity172 group (OVX + E group) treated with @entity4520 0. 25 mg/kg injected intramuscularly qod, high dose @entity172 group (OVX + E 1 mg group) treated with @entity4520 1 mg/kg, @entity1420 (P) group, treated with P 1 mg, OVX + E + P group treated with @entity4520 0.25 mg/kg + @entity1420 1 mg, d @entity342 group (OVX + T group) treated with @entity3033 3 mg/kg, and untreated ovariectomized group (OVX group) receiving no medication. Another 10 @entity35 underwent sham operation. Four weeks later the @entity35 were killed with their bladders and urethras taken out to undergo light and electron microscopy. RESULTS: The thickness of bladder wall of the OVX group was (0.97 +/- 0.11) mm, significant thinner than that of the sham operation group [(1.10 +/- 0.1) mm, P < 0.05)]. The thickness levels of bladder walls of the OVX + E and OVX + T groups were (1.23 +/- 0.12) mm and (1.26 +/- 0.12 mm) respectively, both significantly thicker than that of the OVX group (both P < 0.01). Wider spaces between the detrusor muscle fascicles and degeneration of detrusor muscle cells were seen in the bladder walls of the OVX group, and such phenomena were milder in the OVX + E and OVX + T groups, however, wider spaces between the detrusor muscle fascicles could be seen in the OVX + E + P group too. The @entity1184 effect on the detrusor muscle of the OVX + E 1 mg group was weaker than that of the OVX + E group, a lot of cytoplasmic vacuoles was seen in the 2 groups treated with E, especially the OVX + E 1 mg group. The @entity1494 of the OVX + P group was similar to that of the OVX group. CONCLUSION: Endogenous @entity251 level as well as @entity172 level can significantly affect the @entity1494 with a @entity1184 effect on bladder detrusor muscle. But higher doze of @entity172 also has some unexpected effects which may destroy @entity1494 . In addition, @entity1420 can compromise the effect of @entity172 .
