@entity14911 Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and @entity246 and @entity2650 in Danish XXXX (1980-1996).

@entity1 @entity14911 @entity251 @entity2650 @entity246 @entity6223 @entity600 @entity32407 @entity3918 @entity14912 @entity479
BACKGROUND: Exposure to @entity14911 ( @entity14912 ) may potentially disturb fetal Leydig cell hormone production and male genital development. OBJECTIVES: We aimed to study the associations between levels of amniotic fluid @entity14912 , fetal @entity479 hormone, and @entity32407 ( @entity32407 ) and the prevalence of @entity246 and @entity2650 . METHODS: Using the Danish National @entity1 Registry, we selected 270 @entity246 cases, 75 @entity2650 cases, and 300 controls with stored maternal amniotic fluid samples available in a Danish pregnancy-screening biobank (1980-1996). We used mass spectrometry to measure @entity14912 in amniotic fluid from 645 @entity1 and @entity479 hormones in samples from 545 @entity1 . @entity32407 was measured by immunoassay from 475 @entity1 . Associations between @entity14912 concentration in amniotic fluid, hormone levels, and genital @entity600 were assessed by confounder-adjusted linear and logistic regression. RESULTS: The highest tertile of @entity14912 exposure (> 1.4 ng/mL) in amniotic fluid was associated with a 40% (95% CI: -69, -11%) lower @entity32407 level and an 18% (95% CI: 7, 29%) higher @entity251 level compared with the lowest tertile (< 0.8 ng/mL). Amniotic fluid @entity14912 concentration was not associated with @entity246 or @entity2650 . CONCLUSIONS: Environmental @entity14912 exposure was associated with @entity479 hormone and @entity32407 concentrations in amniotic fluid, but was not associated with @entity246 or @entity2650 in our study population. Additional studies are needed to determine whether associations with fetal hormone levels may have long-term implications for reproductive health. Citation: Toft G, J  nsson BA, Bonde @entity6223 , N  rgaard-Pedersen B, @entity3918 , Cohen A, Lindh CH, Ivell R, Anand-Ivell R, Lindhard MS. 2016. @entity14911 concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and @entity246 and @entity2650 in Danish @entity1 (1980-1996). Environ Health Perspect 124:151-156;   http://dx.doi.org/10.1289/ehp.1409288.
