Influenza A vaccine decreases the incidence of XXXX media in 6- to 30-month-old @entity1 in day care.

@entity1 @entity697 @entity683 @entity2171 @entity2346
OBJECTIVE: To determine if the use of @entity683 vaccine in @entity1 in day care decreases the incidence of @entity2346 media during the @entity683 season. DESIGN: Prospective cohort study. SETTING: Eight day-care centers in North Carolina. @entity1 : One hundred eighty-six @entity1 aged 6 to 30 months. INTERVENTION: Half the @entity1 received trivalent subvirion @entity683 virus vaccine. MEASUREMENTS: @entity697 ( @entity697 ) and @entity2171 media (SOM) were assessed biweekly from mid-November 1993 to mid-March 1994 by visual and tympanometric examinations performed by "blinded" observers. The winter season was divided into three periods-before, during, and after @entity683 season--and the number of @entity1 with @entity697 or SOM during each period was determined. Unadjusted and adjusted odds ratios (ORs) were computed, while controlling for race and sex using logistic regression methods. RESULTS: Influenza vaccine was protective against @entity697 (OR = 0.69, 95% CI, 0.49-0.98) during the @entity683 season. Although there may have been some protection against SOM (OR = 0.75, 95% CI, 0.54-1.02) statistical significance was not achieved. Myringotomy tubes were also significantly protective against @entity697 and SOM during all three time periods, with ORs between 0.34 and 0.52, but the greatest protection was seen during the @entity683 period. CONCLUSIONS: Influenza vaccination of 6- to 30-month-old @entity1 in day care was associated with a decreased incidence of @entity2346 media during the @entity683 season. Myringotomy tubes protected against @entity697 and SOM during all 16 weeks monitored.
