The immunohistochemical analysis of the proliferative activity and the maturity degree of lymphatic vessels in XXXX .

@entity5 @entity957 @entity189 @entity3
@entity5 still represent a major health problem; regional lymph node @entity3 occur in 30-40% of head and neck @entity957 and are associated with unfavorable prognosis and decreased survival. The study included 35 cases of @entity957 ( @entity957 ), which were analyzed by double reactions to determine the proliferative activity (anti-human D2-40  Ki67) and the maturity degree (anti-human D2-40  a-SMA) of lymphatic vessels, both intratumoral (IT) and in the advancing edge (AE), and in relation to clinicopathological prognostic parameters. The mean values of D2-40 lymphatic vessel density (LVD) were higher in AE then in IT level. Poorly differentiated @entity189 , T3  T4, presented the highest LVD values, both IT and in the AE. LVD was higher in advanced stages and metastasizing @entity189 . Ki67 was positive in all cases, Ki67 proliferation index (IP) indicated higher values in poorly differentiated @entity189 , T3  T4, metastasizing ones, both IT and in the AE. LVD and IP Ki67 showed a positive linear correlation. D2-40  Ki67-positive vessels were identified only at the AE or close to it. D2-40  Ki67 LVD had highest values in advanced stages @entity189 , with @entity3 . D2-40  a-SMA-positive vessels were identified only in the neighborhood of the @entity5 and LVD highest values were present in @entity5 and without @entity3 . A negative linear correlation between proliferation and maturity of the lymphatic vessels was found. The study indicated a strong association between lymphatic proliferative activity and lymph node @entity3 , suggesting the need for targeted antilymphangiogenic therapies in @entity957 .
