Differences in the serum nonesterified Fatty Acid profile of young @entity1 associated with a recent history of XXXX and overweight/ @entity28 .

@entity1 @entity2175 @entity6677 @entity5204 @entity28 @entity1474 @entity6221 @entity10194 @entity209 @entity8981 @entity1718 @entity413
BACKGROUND: Nonesterified @entity1718 (NEFA) play pathophysiological roles in @entity209 and @entity2175 ( @entity2175 ). In this study, we analyzed the fasting NEFA profiles of normoglycemic individuals at risk for @entity2175 ( @entity1 with a recent history of @entity6677 (GDM)) in comparison to controls ( @entity1 after a normoglycemic pregnancy). We also examined the associations of NEFA species with overweight/ @entity28 , body fat distribution and insulin sensitivity. SUBJECTS AND METHODS: Using LC-MS/MS, we analyzed 41 NEFA species in the fasting sera of 111 @entity1 (62 post-GDM, 49 controls). Clinical characterization included a five-point oral @entity413 tolerance test (OGTT), biomarkers and anthropometrics, magnetic resonance imaging (n = 62) and a food frequency questionnaire. Nonparametric tests with Bonferroni correction, binary logistic regression analyses and rank correlations were used for statistical analysis. RESULTS: @entity1 after GDM had a lower molar percentage of total @entity1718 ( @entity10194 ; 38.55% vs. 40.32%, p = 0.0002) than controls. At an explorative level of significance several NEFA species were associated with post-GDM status (with and without adjustment for body mass index (BMI) and HbA1c): The molar percentages of 14:0, 16:0, 18:0 and 18:4 were reduced, whereas those of 18:1, 18:2, 20:2, 24:4, @entity6221 ( @entity8981 ), @entity1474 ( @entity5204 ) and total n-6 NEFA were increased. BMI and the amount of body fat correlated inversely with several @entity10194 and @entity8981 and positively with various @entity5204 species over the whole study cohort (abs(  )>= 0.3 for all). 14:0 was inversely and BMI-independently associated with abdominal visceral adiposity. We saw no correlations of NEFA species with insulin sensitivity and the total NEFA concentration was similar in the post-GDM and the control group. CONCLUSION: In conclusion, we found alterations in the fasting NEFA profile associated with a recent history of @entity6677 , a risk marker for @entity2175 . NEFA composition also varied with overweight/ @entity28 and with body fat distribution, but not with insulin sensitivity.
