A case of @entity1368 in pregnancy: do LH and GNRH receptors have a potential role in regulating XXXX secretion?

@entity1 @entity19040 @entity1369 @entity23042 @entity652 @entity1368 @entity10548
OBJECTIVE: The mechanisms inducing steroidogenesis in @entity1368 ( @entity1368 ) remain poorly defined. It was recently demonstrated that some G-protein-coupled receptors are abnormally expressed in @entity1369 -producing @entity652 (APA). We evaluated the potential role of LH and GNRH receptors ( @entity10548 (or @entity10548 ) and @entity23042 ) in regulating @entity1369 secretion in a @entity1 with APA arising during pregnancy (index case) and in a subset of other @entity1 with @entity1368 . @entity1 AND METHODS: GNRH test was performed in the index case, 11 other @entity1368 , and 5 controls. @entity23042 and @entity10548 expressions were examined in 23 APA and 6 normal tissues. RESULTS: @entity1369 response increased significantly (114%) in the index case after GNRH test was performed preoperatively, while it was blunted after adrenalectomy. @entity1369 also increased after @entity1 chorionic gonadotropin and @entity19040 stimulation. A partial @entity1369 response to GNRH was observed in other 7/11 @entity1368 , while a significant response was observed in two @entity1 . Controls did not respond to GNRH test. @entity23042 was overexpressed and @entity10548 expression was moderate in the APA tissue from the index case. Moreover, @entity10548 was found in normal adrenals and overexpressed in 6/22 APA. @entity23042 was overexpressed in 6/22 APA, 2 of them with a 95- and 109-fold higher expression than normal. A correlation between the clinical and molecular findings was observed in five out of seven @entity1 . CONCLUSION: We describe a case of @entity1368 diagnosed during pregnancy, which appeared to correlate with aberrant @entity10548 and @entity23042 expression. Our findings suggest that a subset of @entity1 with @entity1368 has aberrant @entity10548 and @entity23042 expression, which could modulate @entity1369 secretion.
