Spontaneous activity of ventral root axons following XXXX .

@entity1425 @entity5543 @entity128 @entity1897 @entity35 @entity2950 @entity1118
In 18 @entity35 , the left sciatic nerve was divided at the mid-femur level. Seven to 9 days later, microfilament recordings were made from the ipsilateral L-5 ventral root. Spontaneous activity in the ventral root, ranging from 0.1 to 6.1 Hz, was recorded in 12 of the 18 animals. Conduction velocity determinations showed this activity to be in @entity5543 and A-delta fibers. Recordings in 10 normal L-5 ventral roots from five control @entity35 showed no spontaneous activity. In the @entity35 with sciatic nerve division, the ongoing discharge appeared to originate in the cut end of the nerve since mechanical stimulation of the @entity2950 produced synchronous ventral root activity. Furthermore, cooling of the @entity2950 inhibited the spontaneous discharge, whereas with rewarming it returned. Spontaneous ventral root activity was also increased by systemic application of @entity1425 . This activity was qualitatively similar to spontaneous activity that has been recorded in dorsal root microfilaments after @entity1897 . The observation of an ongoing discharge in potentially nociceptive ventral root axons subsequent to @entity128 may be relevant to the mechanism of @entity1118 of peripheral origin.
