@entity2971 in 57 XXXX and adolescents.

@entity1 @entity2971 @entity5 @entity900 @entity786 @entity4316 @entity3438 @entity1891 @entity3 @entity1732 @entity5713
Fifty-seven @entity1 with @entity2971 (GCTs) treated at our center between 1962 and 1979 were evaluated to determine 1) the prognostic value of disease stage, @entity5 histology, primary site, and @entity1 age; 2) results of therapy; and 3) patterns of @entity3 . The 35 @entity1 and 22 @entity1 were from 1 week to 18 years old (median 5 yr). Primary sites were ovarian (20), testicular (10), sacrococcygeal (12), retroperitoneal (7), mediastinal (5), and other (3). Cox regression analysis indicated that stage was the most important prognostic variable. @entity5 were usually advanced at diagnosis, but @entity5 site did not have prognostic value independent of disease stage. Neither @entity1 age nor @entity5 histology significantly influenced outcome. Drugs active against malignant GCTs included @entity1891 , @entity786 , and @entity4316 in combination and @entity5713 , @entity1732 , and @entity900 . Radiation alone cured nondisseminated @entity3438 . The most common sites of @entity3 were lungs, liver, central nervous system, and bone; other sites were infrequently involved. We conclude that stage was the most important prognostic variable, extragonadal @entity5 were usually advanced at diagnosis, and similarities in the histogenesis, metastatic pattern, and response to therapy, regardless of primary site, justify the consideration of childhood malignant GCTs as one group.
