Efficacy and safety evaluation of intra-articular injection of @entity927 in XXXX operation with temporarily drainage close.

@entity1 @entity190 @entity928 @entity1003 @entity49 @entity1150 @entity348 @entity86 @entity927 @entity2827
OBJECTIVE: To investigate the efficacy and safety of @entity927 ( @entity928 ) injection during primary @entity348 ( @entity348 ) for @entity86 . METHODS: 100 cases of @entity1 admitted to our hospital and underwent primary unilateral @entity348 from January 2012 to December 2014 were enrolled in this study and they were divided randomly into two groups. For the @entity928 group, 1 g @entity928 was dissolved in 50 ml 0.9% @entity2827 solution and injected after prosthesis implantation but before cavity close. Conventional drainage clamping was carried for 4 h and the drainage tube was removed 48 h postoperative. For the control group, similar measures were taken except for that no @entity928 was dissolved in 0.9% @entity2827 solution. Postoperative hemoglobin, @entity1003 index, total @entity190 volume, drainage volume, blood transfusion rate and lower extremity @entity1150 ( @entity1150 ) rate in both groups were observed and the efficacy and safety of this surgical treatment were evaluated. RESULTS: There were no significant differences in operation time, postoperative platelet and APPT, D-dimer, lower limb @entity49 incidence rate 1 week after operation between the two groups. Postoperative drainage volume, hemoglobin, total @entity190 and blood transfusion rate in the @entity928 group were significantly lower than those of the control group. Ecchymosis of lower extremity peripheral incision and its surroundings was significantly milder than that of the control group. CONCLUSION: Intraoperative intra-articular injection of @entity928 in @entity348 can significantly reduce the @entity86 and blood transfusion rate at the early stage after operation.
