@entity4149 levels are associated with @entity2690 resistance in XXXX with @entity1561 .

@entity1 @entity1522 @entity82 @entity68 @entity5 @entity1674 @entity5906 @entity2690 @entity1254 @entity1561 @entity3929 @entity165 @entity36781 @entity1575 @entity3689 @entity4149
OBJECTIVE: @entity3689 imbalance is often found in @entity1 with @entity82 , and this imbalance is associated with @entity2690 resistance. However, the mechanism underlying the relationship between @entity3689 imbalance and @entity2690 resistance remains unclear. We evaluated serum @entity3689 concentrations in @entity1 with @entity1561 to determine if any of the levels of @entity1522 were associated with the biochemical markers and @entity82 stage of @entity1561 ( @entity1561 ). METHODS: In 137 @entity1 with @entity1561 who underwent liver biopsy, plasma levels of branched-chain @entity3689 (BCAA), @entity4149 ( @entity36781 ), and the BCAA-to- @entity36781 ratio values were determined using mass spectroscopy. These values were then assessed for associations with @entity82 stage, anthropometric markers (age, sex, and body mass index), biochemical markers ( @entity3929 aminotransferase, @entity5906 aminotransferase, y-glutamyl transpeptidase, albumin, platelet count, total @entity165 , @entity1674 , low-density lipoprotein @entity165 , and glycosylated hemoglobin), and relevant disease-specific biomarkers (homeostasis model assessment of @entity2690 resistance [HOMA-IR], serum @entity68 , ferritin, leptin, @entity1254 , high-sensitivity C-reactive protein, and hyaluronic acid). RESULTS: Serum albumin levels, plasma BCAA levels, and BCAA-to- @entity36781 ratio values were negatively associated with the @entity82 stage. In contrast, @entity36781 levels increased with increasing @entity5 . @entity36781 levels were also correlated with HOMA-IR results. CONCLUSION: Plasma BCAA levels in @entity1 with @entity1561 decreased with increasing @entity1575 , while @entity36781 levels increased with increasing fibrotic stage. These results suggest that @entity3689 imbalance and @entity2690 resistance are intimately involved in a complex pathogenic mechanism for @entity1561 .
