Assay for beta-glucuronidase in cerebrospinal fluid: usefulness for the detection of XXXX .

@entity1 @entity4008 @entity5 @entity2800 @entity74 @entity420 @entity413 @entity3554
The specificity and sensitivity of the assay for beta-glucuronidase in cerebrospinal fluid were evaluated to determine the usefulness of this test for the detection of @entity3554 . The enzyme activity was first measured in cerebrospinal fluid from 131 @entity1 with @entity74 and was then prospectively measured in cerebrospinal fluid from 30 @entity1 with cytologic results that were positive for or suggestive of @entity5 . Within the first group, elevated levels of beta-glucuronidase were found only among @entity1 with @entity5 in the central nervous system, including @entity3554 . Among 26 @entity1 with @entity5 in the central nervous system, including @entity3554 . Among 26 @entity1 with positive cytologic results, 13 had elevated beta-glucuronidase activities. Elevated values were more frequent among @entity1 with @entity420 (75%) and @entity2800 (60%). The @entity1 with these two disorders also had the highest enzyme activities. The correlation of th beta-glucuronidase level with other cerebrospinal fluid values, including total protein, @entity413 content, and cell count, was not significant. The findings of this study indicate that measurement of beta-glucuronidase in cerebrospinal fluid can be used as an adjunctive diagnostic test for @entity3554 . The results should be interpreted with caution, however, because of the possibility that the elevated enzyme levels may be due to acute or subacute @entity4008 .
