Memory Similarities Between Essential @entity400 and XXXX : A Final Common Pathway?

@entity1 @entity75 @entity191 @entity400 @entity717 @entity2414
OBJECTIVE: A growing body of literature supports the view that essential @entity400 (ET) involves alteration of cerebellar-thalamo-cortical networks which can result in working @entity2414 . In this study, we tested the hypothesis that individuals with ET would exhibit worse performance on memory tasks requiring more intrinsic organization and structuring (i.e., word lists) relative to those with fewer 'executive' demands (i.e., stories), similar to that previously observed in individuals with @entity191 ( @entity191 ). METHOD: @entity1 included a convenience sample of 68 ET @entity1 and 68 idiopathic @entity191 @entity1 , retrospectively matched based on age, education, and sex. All @entity1 underwent routine neuropsychological evaluation assessing recent memory, @entity2414 , language, and executive function. Memory measures included the Hopkins Verbal Learning Test-R and @entity2414 . RESULTS: Both ET and @entity191 @entity1 performed significantly worse on word list than story memory recall tasks. The magnitude of the difference between these two memory tasks was similar for ET and @entity191 @entity1 . In both @entity1 groups, performance on measures of executive function and @entity2414 was not distinctly correlated with word list vs. story recall. CONCLUSIONS: These findings suggest that @entity75 in both ET and @entity191 may negatively influence performance on memory tests that are not inherently organized. Although the pathophysiology of these two ' @entity717 ' are quite distinct, both have downstream effects on thalamo-frontal circuitry which may provide a common pathway for a similar memory phenotype. Findings are discussed in terms of neuroimaging evidence, conceptual models, and best practice.
