Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in XXXX isolated from @entity293 in Japan.

@entity1 @entity1069 @entity68 @entity56999 @entity2885 @entity2335 @entity293 @entity526
PURPOSE: Many virulence factors (VFs) have been reported in uropathogenic @entity526 . Recently we found a putative uropathogenic island including a gene encoding uropathogenic specific protein (USP). We have described the association between usp and other VFs reported previously. In the current study we examined epidemiological associations among 5 putative uropathogenic VFs. MATERIALS AND METHODS: In 427 @entity526 strains, including 194, 76 and 107 isolates from @entity1 with @entity2335 , @entity2885 and @entity1069 , respectively, and 50 isolates from the stool of healthy adults, we detected @entity56999 siderophore receptor (iroN), @entity68 regulated gene A homologue adhesin (iha), group II capsule (kpsMT) and outer membrane protease T (ompT) by polymerase chain reaction assays. We analyzed their distribution and genetic association. RESULTS: Relative prevalence ratios of iroN, iha, kpsMT, ompT and usp were 2.0 to 4.3 times more frequently in @entity293 isolates than in fecal isolates. Isolates from @entity1069 were frequently associated with iroN, ompT and usp, whereas isolates from @entity2885 frequently harbored usp. Together with iroN and iha we noted S-/F-fimbriae and iucD aerobactin (OR 95.9 and 187.2), while usp showed a close association with kpsMT and ompT (OR 38.3 and 38.4, respectively). CONCLUSIONS: Of the putative uropathogenic VFs examined iroN, iha, kpsMT, ompT and usp were frequently associated with @entity293 . Especially iroN and usp were most frequently associated with @entity1069 . Some VFs were closely associated with a specific anatomical site of infection. Strong associations among several VFs might indicate not only well-known genetic linkages, but also unknown functional linkages among these VFs.
