Prevalence of normal TSH value among XXXX with autonomously functioning thyroid nodule.

@entity1 @entity1374
BACKGROUND: International guidelines significantly diverge on the effectiveness of @entity1374 ( @entity1374 ) in the initial work-up of thyroid nodules. In particular, the role of @entity1374 to detect or exclude the presence of @entity1374 ( @entity1374 ) in @entity1 with normal serum thyrotropin (TSH) is still a matter to debate. Here, we aimed to review the literature on the prevalence of normal TSH value among @entity1 with @entity1374 and meta-analyse data of the retrieved eligible papers. MATERIALS AND METHODS: A comprehensive literature search of studies published from January 2000 to December 2014 on @entity1374 detected by @entity1374 was performed. Records reporting serum TSH values in @entity1374 were selected. Pooled prevalence of @entity1374 with normal TSH values was calculated on a per- @entity1 analysis including 95% confidence intervals (95% CI). RESULTS: Eight records including 2761 @entity1374 were selected for the meta-analysis. Pooled prevalence of @entity1374 with normal TSH detected by @entity1374 was 50% (95% CI: 32-68%). Selection bias in the included studies and heterogeneity among studies were potential limitations of the meta-analysis. CONCLUSIONS: Present meta-analysis shows that about one in two @entity1 with @entity1374 demonstrated by @entity1374 has a TSH value within normal references. As a consequence, TSH measurement may not be considered as effective as a single tool to detect or exclude @entity1374 , and @entity1374 remains mandatory.
