[ @entity8595 synthetase activity of long-chain mono and XXXX in beef liver preparations (author's transl)].

@entity1 @entity16740 @entity1718 @entity6 @entity2365 @entity73094 @entity13961 @entity2974 @entity9931 @entity8595 @entity6178 @entity10989 @entity35 @entity40702 @entity6625 @entity855 @entity17636
Higher omega-oxidation activities in the diabetic @entity1 and the starved one suggest that omega-oxidation mechanism plays an important role under these conditions. @entity13961 that is the final product of omega-oxidation can be metabolized further by beta-oxidation, subsequently, formation of @entity16740 and short-chain @entity13961 might be increased in the liver. The physiological significance of omega-oxidation might consist in supplying the substrate of @entity2974 cycle for utilization of @entity6625 and excreting the short-chain @entity17636 in urine resulting in the decrease of @entity6178 bodies in the blood, especially in @entity6 and starvation. On the bases of these information, it is important to investigate the metabolism of @entity10989 . Generally, @entity1718 must be activated before they enter the metabolic pathway. By in vitro studies with @entity35 liver homogenate, we have recently demonstrated that octadecaned-ioic acid must be activated by @entity855 -Mg2+ and @entity9931 as @entity40702 is. However, it has not been studied to compare the activity of @entity8595 synthetase on mono and @entity13961 . So, in this report, we assayed the activity of @entity8595 synthetase in beef liver preparations using palmitic or @entity73094 (C1;16) as substrate. The results are as follows 1) Activation capacity of the supernatant of sonicated mitochondria was less than that of sonicated microsome for either @entity2365 or hexadecanedioate. 2) Activation capacity for hexadecanedioate was less than that for @entity2365 in both supernatant of sonicated mitochondria and that of sonicated microsome. 3) In our experiment, it might be suggested that the subcellular distribution of hexadecanedioate activation is almost identical with that of @entity2365 activation.
