Low mortality from all causes, including @entity583 , in well-controlled XXXX treated with a beta-blocker plus other antihypertensives.

@entity1 @entity64 @entity101 @entity412 @entity583 @entity2165
The aim of the present study was to monitor the efficacy of treatment, morbidity and mortality over a 10-year period in 939 moderate to severe @entity101 @entity1 . All @entity1 were treated in the same @entity101 clinic with the beta 1-selective agent @entity2165 , administered either alone or more usually with a diuretic with or without a vasodilator or other agents. Survival rates were compared with predicted survival rates, had the @entity101 not been treated, and also with those of a local reference population matched for age and sex. After a mean follow-up time of 6.1 years, mean blood pressure (BP) was significantly lowered from 183/109 to 145/87 mmHg. Biochemical disturbance was minimal. There were 79 withdrawals from treatment, of whom 37 were lost to follow-up. There were 91 deaths on intention to treat. Systolic blood pressure (SBP) on treatment, and not initial BP, was a powerful predictor of mortality. @entity1 of all age groups with well-controlled SBP were less likely to die, particularly from @entity583 , than those with less well controlled SBP (P less than 0.001). However, due to possible J-curve relationships between treated BP and outcome, lowering SBP below 140-150 mmHg in the elderly, and the diastolic blood pressure (DBP) below about 85 mmHg, may not be beneficial. Total mortality and mortality due to @entity583 was about 60% [corrected], of predicted level, had a high BP not been treated, being similar to that in a local reference control population (age- and sex-matched). The death rate from @entity64 was reduced to about 50% of that predicted. @entity1 who died showed a mean fall in mean serum @entity412 concentration in contrast to the mean increase that occurred in survivors. It is concluded that @entity1 with moderate to severe @entity101 who obtain a high level of general health care and optimal control of BP for up to 10 years, experience a significant decrease in total mortality rate and death from @entity583 and @entity64 .
