@entity15061 overexpression promotes @entity13236 / XXXX signaling in @entity14 .

@entity1 @entity32 @entity10772 @entity5 @entity4104 @entity13236 @entity584 @entity29 @entity14 @entity15061 @entity688 @entity13235
UNASSIGNED: The mucosal immune response in the setting of intestinal @entity32 contributes to @entity14 ( @entity14 ). @entity688 signaling has central role in gut homeostasis and is @entity29 ( @entity29 ). Out of two @entity688 receptor subunits, @entity10772 and @entity15061 , the latter is shared among the @entity688 family of cytokines and activates STAT signaling. @entity4104 is oncogenic in @entity14 , however, knowledge about @entity688 signaling upstream of @entity4104 in @entity14 is lacking. Here, expression of @entity688 signaling genes was examined in matched pairs from normal and @entity5 tissue from @entity14 @entity1 showing overexpression (mRNA, protein) of @entity15061 and @entity4104 but not @entity10772 . @entity15061 over-expression was related to microsatellite- stability. Transient overexpression of @entity15061 in HT29 cells increased proliferation upon ligand activation ( @entity688 , @entity13236 ). @entity13236 and not @entity688 phosphorylated @entity4104 along with increased phosphorylation of @entity584 and ERK. A significantly higher expression of @entity13235 and @entity15061 was also confirmed in separate cohort of @entity14 samples. @entity13236 expression was elevated in gut mucosa from @entity1 with @entity29 and @entity5 which also exhibited increased expression of @entity13235 but not its co-receptor @entity15061 . Overall, these data indicate that overexpression of @entity15061 and @entity4104 contribute to @entity14 through @entity13236 / @entity4104 signaling.
