A dietary intervention for chronic XXXX : a randomized controlled pilot study.

@entity6 @entity16 @entity3949 @entity2186 @entity164 @entity2531 @entity158
BACKGROUND: @entity3949 is a common and often debilitating condition for which available treatments are limited. Because a low-fat plant-based diet has been shown to improve glycemic control in individuals with @entity164 2 @entity6 , we hypothesized that such a diet would reduce @entity2531 of @entity3949 . METHODS: In this 20-week pilot study, individuals with @entity164 2 @entity6 and @entity3949 were randomly assigned to two groups. The intervention group was asked to follow a low-fat, plant-based diet, with weekly classes for support in following the prescribed diet, and to take a @entity2186 supplement. The control group was asked to take the same @entity2186 supplement, but received no other intervention. At baseline, midpoint and 20 weeks, clinical, laboratory and questionnaire data were collected. Questionnaires included an analog 'worst @entity158 ' scale, Michigan @entity16 Screening Instrument, global impression scale, Short Form McGill Pain Questionnaire, @entity16 Total Symptom Score, a weekly @entity158 diary and Norfolk Quality of Life Questionnaire. RESULTS: After 20 weeks, body weight change with the intervention was -6.4   kg (95% confidence interval (CI) -9.4 to -3.4, P<0.001) in an effect size analysis. Electrochemical skin conductance in the foot improved by an average of 12.4 microseimens (95% CI 1.2-23.6, P=0.03) with the intervention in an effect size analysis. The between-group difference in change in @entity158 , as measured by the @entity158 questionnaire, was -8.2 points (95% CI -16.1 to -0.3, P=0.04). Michigan @entity16 Screening Instrument questionnaire score change was -1.6 points (95% CI -3.0 to -0.2, P=0.03). CONCLUSIONS: Improvements were seen in some clinical and @entity158 measures. This pilot study suggests the potential value of a plant-based diet intervention, including weekly support classes, for treating @entity3949 .
