Low concentrations of XXXX but not of @entity3733 ( @entity3733 ) impair reciprocal retinal signal transduction.

@entity73142 @entity1246 @entity4437 @entity3733 @entity1068 @entity141 @entity291 @entity528
BACKGROUND: The model of the isolated and superfused retina provides the opportunity to test drugs and toxins. Some chemicals have to be applied using low concentrations of organic solvents as carriers. Recently, @entity73142 ) and T-type (Cav3.2) voltage-gated @entity141 channels were identified as participating in reciprocal inhibitory retinal signaling. Their participation is apparent, when low concentrations of @entity4437 (15   M) are applied during superfusion leading to an increase of the ERG b-wave amplitude, which is explained by a reduction of amacrine @entity1246 -release onto @entity528 . During these investigations, differences were observed for the solvent carrier used. METHODS: Recording of the transretinal receptor potentials from the isolated @entity291 retina. RESULTS: The pretreatment of @entity291 retina with 0.01  % (v/v) @entity3733 did not impair the @entity4437 -mediated increase of the b-wave amplitude, which was 1.31-fold        0.03 of initial value (n   =   4). However, pretreatment of the retina with the same concentration of @entity1068 impaired reciprocal signaling (0.96-fold        0.05, n   =   4). Further, the implicit time of the b-wave was increased, suggesting that @entity1068 itself but not @entity3733 may antagonize @entity1246 -receptors. CONCLUSION: @entity1068 itself but not @entity3733 may block @entity1246 receptors and cause an amplitude increase by itself, so that reciprocal signaling is impaired.
