Intermittent fasting favored the resolution of XXXX infection in middle-aged BALB/c @entity19 .

@entity2491 @entity281 @entity2819 @entity19
Intermittent fasting (IF) reportedly increases resistance and intestinal IgA response to @entity2491 infection in mature @entity19 . The aim of this study was to explore the effect of aging on the aforementioned improved immune response found with IF. Middle-aged male BALB/c @entity19 were submitted to IF or ad libitum (AL) feeding for 40  weeks and then orally infected with @entity2491 . Thereafter, infected animals were all fed AL (to maximize their viability) until sacrifice on day 7 or 14 @entity281 . We evaluated body weight, bacterial load (in feces, Peyer's patches, spleen and liver), total and specific intestinal IgA, lamina propria IgA+ plasma cells, plasma @entity2819 , and messenger RNA (mRNA) expression of a-chain, J-chain, and the polymeric immunoglobulin receptor (pIgR) in liver and intestinal mucosa. In comparison with the infected AL counterpart, the infected IF group (long-term IF followed by @entity281 AL feeding) generally had lower intestinal and systemic bacterial loads as well as higher total IgA on both @entity281 days. Both infected groups showed no differences in @entity2819 levels, body weight, or food and caloric intake. The increase in intestinal IgA was associated with enhanced pIgR mRNA expression in the intestine (day 7) and liver. Thus, to maintain body weight and caloric intake, IF elicited metabolic signals that possibly induced the increased hepatic and intestinal pIgR mRNA expression found. The increase in IgA probably resulted from intestinal IgA transcytosis via pIgR. This IgA response along with phagocyte-induced killing of bacteria in systemic organs (not measured) may explain the resolution of the @entity2491 infection.
