[Prophylactic effect of XXXX on postoperative @entity299 (author's transl)].

@entity1 @entity712 @entity3763 @entity101 @entity26 @entity519 @entity453 @entity299 @entity432 @entity583
@entity3763 (ISD) was administered before, during and after 178 operations performed on 127 @entity1 with @entity432 . Its influence on postoperative @entity583 , @entity712 and mortality was tested by comparison with 188 operations performed on 140 @entity1 with @entity101 and/or old @entity583 receiving no ISD prophylaxis. Risk of @entity299 was similar in both groups. Mortality in the ISD-treated group was significantly lowered as compared with the control group and was about half of the overall mortality in @entity1 with @entity432 operated on at our hospital over the past 10 years. This difference depended partly on the influence of ISD on @entity299 . Post-operative @entity583 during ISD prophylaxis occurred in 0.6% of cases as compared with 3.7% in the control group (p less than 0.05), whilst the respective values for postoperative @entity712 were 5.7% and 18.2% (p less than 0.001). Both complications are related to absolute or relative @entity519 during the post-operative stress period. ISD is effective by lowering cardiac preload and afterload and thereby diminishing myocardial @entity26 demand. ISD is the drug of choice for surgical @entity1 since it provides a steady and long-lasting effect after sublingual absorption. ISD prophylaxis during the perioperative period is indicated in cases with @entity453 and with increased cardiac preload or afterload.
