Are solitary XXXX entirely benign?

@entity1 @entity1377 @entity0 @entity5 @entity1185 @entity189 @entity513
HYPOTHESIS: @entity0 are potentially malignant and are associated with a higher risk of @entity0 . DESIGN: Retrospective review of all pathological reports containing @entity0 (1983-2000) and review of selected specimens. SETTING: Tertiary, referral, university-affiliated medical center. @entity1 : Ninety-five @entity1 with a breast specimen containing a @entity1185 or @entity1185 . @entity1 with overt @entity1377 without @entity1185 were excluded. INTERVENTION: All histopathological characteristics of the @entity1185 and the surrounding tissue were noted. The incidence of malignant and other proliferative histopathological findings were analyzed, comparing solitary @entity513 cases to @entity1185 cases. The Fisher exact test and chi2 test were applied for statistical analysis. MAIN OUTCOME MEASURES: Surgical @entity513 should include margins wide enough to secure removal of any proliferative tissue within or around the @entity1185 and to enable thorough evaluation of the risk for future @entity0 . RESULTS: @entity1185 were associated with @entity0 in 7 @entity1 (10%) in this series. An additional 9% (n = 6) presented with invasive or noninvasive @entity189 . @entity1185 was noted in 6% of @entity1 (n = 4). The risk of associated @entity5 was not significantly different between solitary @entity513 and @entity1185 . CONCLUSION: Increased risk of @entity0 is associated with all forms of @entity1185 .
