XXXX standard form expression as a predictor of progression in high risk superficial @entity150 .

@entity1 @entity2735 @entity5 @entity1759 @entity150
OBJECTIVE: The purpose of this study was to assess the significance of the standard @entity1759 adhesion molecule expression in predicting progression of high risk superficial @entity150 in the short term. METHODS: Sixty-six @entity1 (51 males and 15 females, aged 27 to 89 years (mean 64.75 years) with primary superficial transitional cell @entity150 initially treated with transurethral resection (TURBT) were enrolled in the study. Only pTa/pT1 grade 2 @entity5 as well as all grade 3 @entity5 were included in this study. All @entity5 samples obtained after the resection were immunohistochemically evaluated for the expression of the @entity1759 standard molecule. Fifty eight @entity1 remained during the follow up period which ranged from 3 to 36 months (mean 11.8 months). @entity5 progression in the short term was considered as the critical end point of interest in this study. The prognostic significance of @entity5 stage, grade, presence of @entity2735 ( @entity2735 ) and expression of @entity1759 in determining the risk for progression, was studied with both univariate (log rank test) and multivariate (Cox proportional hazards) methods of analysis. RESULTS: Kaplan-Meier survival curves indicated that a shorter median progression-free survival is expected for those @entity1 with G3 @entity150 (p = 0.0055), concomitant @entity2735 (p = 0.0051), and loss of expression of @entity1759 (p = 0.0015), whereas a similar association with stage was not detected (p = 0.5793). The cox regression multivariate analysis did not yield a significant result for any of the studied parameters therefore no one of the factors taken into account can serve as an independent predictor of progression in superficial @entity150 in the short term. CONCLUSION: The immunohistochemically detectable loss of the expression of @entity1759 standard form from superficial @entity150 samples may be, complementary to the established prognostic factors, a useful predictor of @entity5 progression in the short term.
