Acute effects of calcium supplements on blood pressure and @entity1003 : secondary analysis of a randomised controlled trial in post-menopausal XXXX .

@entity1 @entity1003 @entity13621 @entity551 @entity9495
UNASSIGNED: Recent evidence suggests that @entity9495 supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various @entity9495 supplements on blood @entity9495 levels, we also investigated the effects of @entity9495 supplements on blood pressure and their acute effects on @entity1003 . We randomised 100 post-menopausal @entity1 to 1 g/d of @entity9495 or a placebo containing no @entity9495 . Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. @entity1003 was measured by thromboelastography (TEG) in a subgroup of @entity1 (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The @entity551 was smaller in the @entity9495 group compared with the control group by >5 mmHg between 2 and 6 h (P <=0  02), and the @entity551 was smaller at 2 h (between-groups difference 4  5 mmHg, P=0  004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the @entity13621 and control groups. At 4 h, the increase in the coagulation index was greater in the @entity13621 group compared with the control group (P=0  03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that @entity9495 supplements may acutely influence blood pressure and @entity1003 . Further investigation of this possibility is required.
