Prenatal Protein Malnutrition Affects the Density of GABAergic Interneurons During Hippocampus Development in XXXX .

@entity35 @entity1246 @entity3147
BACKGROUND: Prenatal @entity3147 disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local @entity1246 inter-neurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the @entity1246 cell population of prenatal @entity3147 @entity35 . OBJECTIVE: This experimental study was conducted to ascertain the effects of prenatal @entity3147 on the density of GABAergic interneurons at the cornus ammonis and fascia dentata in @entity35 . METHODS: Animals were investigated under two nutritional conditions: (i) prenatal @entity3147 group fed 6% protein, and (ii) well-nourished control group fed 25% protein. Using an antibody for @entity1246 , immunoreactive cells (GABAergic) were assessed in the rostral-caudal direction of the dorsal hippocampus at four levels. RESULTS: (i) In 30-day-old @entity35 with prenatal @entity3147 , the fascia dentata had an average of 27% more GABAergic cells than the control group; this higher amount was not detectable at 90 days. (ii) There was a significant 18% increase in GABAergic neurons at level 1 of the cornus ammonis at 90 days of age. CONCLUSIONS: There was an increase in the population of interneurons in the fascia dentata and cornus ammonis in prenatal @entity3147 @entity35 . We conclude that prenatal hypoprotein @entity3147 produces changes at 30 days in the fascia dentata. Results suggest that prenatal @entity3147 also produces a delay in the programmed chronology of @entity1246 interneurons. Finally, in cornus ammonis, at 90 days of age, prenatal @entity3147 showed an increase only at level 1; this effect may be evidenced in the long term, despite postnatal rehabilitation.
