XXXX after breast-conserving therapy.

@entity1 @entity66 @entity0 @entity146 @entity5 @entity5426
BACKGROUND: @entity5426 arising in the irradiated breast after breast-conserving therapy is being reported with increasing frequency. As more @entity1 undergo breast-conserving therapy, the incidence can be expected to increase. Surgeons, medical oncologists, and radiation oncologists will be faced with difficult management decisions for this @entity146 . METHODS: A comprehensive review of all English-language reports of @entity5426 after breast-conserving therapy was performed. Approximately 100 cases were reviewed for treatment details and outcome analysis was performed. RESULTS: Surgical excision is associated with very high rates of disease recurrence (55 of 75 @entity1 with at least 1 year of follow-up; 73%). @entity66 recurrences in the @entity5 bed or along the mastectomy scar are a component of almost all recurrences (96%). Distant metastases develop simultaneously or shortly after local recurrences. Hyperfractionated radiotherapy has successfully prevented @entity66 recurrences in a limited number of @entity1 . CONCLUSIONS: @entity5426 after breast-conserving therapy is increasingly diagnosed in a small but significant portion of @entity0 survivors. The aggressive nature of this disease demands further investigation of adjuvant therapy to prevent recurrence of disease after surgery.
