Activation of autophagy and @entity4334 -binding domain @entity368 -rich repeat-containing-like receptor family, pyrin domain-containing 3 inflammasome during @entity13556 -associated XXXX .

@entity1 @entity8 @entity1310 @entity82 @entity368 @entity235 @entity234 @entity740 @entity177 @entity281 @entity13556 @entity4334 @entity631
@entity740 is a major contributor to @entity1 and companion animal morbidity and mortality. Renal complications are sequelae of @entity235 and @entity1 @entity234 ( @entity234 ). Despite the high incidence of @entity281 -mediated @entity631 , little is known about pathogenesis of @entity8 . @entity13556 -infected @entity235 are a naturally occurring model of @entity234 -associated @entity631 . @entity631 type I [24 of 25 (96%)], with interstitial lymphoplasmacytic @entity1310 [23 of 25 (92%)], and glomerular and interstitial @entity82 [12 of 25 (48%)] were predominant lesions. An ultrastructural evaluation of glomeruli from animals with @entity234 identified mesangial cell proliferation and interposition. Immunohistochemistry demonstrated significant @entity13556 antigen, IgG, and C3b deposition in @entity234 @entity235 glomeruli. Asymptomatic and symptomatic @entity235 had increased glomerular @entity4334 -binding domain @entity368 -rich repeat-containing-like receptor family, pyrin domain containing 3 and autophagosome-associated microtubule-associated protein 1 light chain 3 associated with @entity8 severity. Transcriptional analyses from symptomatic @entity235 confirmed induction of autophagy and inflammasome genes within glomeruli and tubules. On the basis of temporal @entity234 staging, @entity631 was initiated by IgG and complement deposition. This deposition preceded presence of @entity4334 -binding domain @entity368 -rich repeat-containing-like receptor family, pyrin domain containing 3-associated inflammasomes and increased light chain 3 puncta indicative of autophagosomes in glomeruli from @entity235 with clinical @entity234 and @entity177 . These findings indicate potential roles for inflammasome complexes in @entity8 during @entity234 and autophagy in ensuing cellular responses.
