XXXX in sickle cell trait: does it exist?

@entity1 @entity455 @entity548 @entity2479 @entity1713 @entity262 @entity3458 @entity989
BACKGROUND: @entity1 with @entity3458 are known to be at risk for @entity989 . However, there are reports of @entity989 in @entity1 with sickle cell trait without @entity262 . There are no population-based studies addressing the risk of @entity3458 in this group. We performed a study to clarify the relation between sickle cell trait and @entity989 in healthy subjects. METHODS: We reviewed the medical records of 100 @entity1 with sickle cell disease who attended the Sickle Cell Clinic at the Hospital for Sick @entity1 , Toronto. We then contacted 200 parents with sickle cell trait, of whom 32 agreed to participate in the study. All @entity1 were proven to have hemoglobin AS status with prior hemoglobin electrophoresis. An ophthalmologic history was obtained, and a complete ophthalmologic examination was performed. We defined @entity3458 as any salmon @entity548 , iridescent spots, black sunbursts, @entity2479 or @entity1713 . The evaluation also included attempts to identify the more subtle signs of @entity3458 , such as optic nerve head vascular changes, vascular tortuosity, macular changes (e.g., @entity455 ) and peripheral arteriovenous anastamoses. Blood samples were obtained for complete blood count, reticulocyte count and smear. RESULTS: We found no cases of @entity3458 among the 32 subjects. Ten of 30 subjects had a high reticulocyte count (greater than 120 x 10(9)/L); however, there were no associated eye findings in this subgroup. INTERPRETATION: Our results indicate that there is no increased risk of @entity989 in healthy @entity1 with sickle cell trait.
