14-3-3   positive expression is associated with a poor prognosis in @entity1 with XXXX .

@entity5 @entity1 @entity28333 @entity463
BACKGROUND: When identifying clinical markers predicting clinical outcome, disease recurrence and resistance to therapies often determine the diagnosis and therapy of some @entity5 types. OBJECTIVE: To investigate whether @entity28333 positive expression is an indicator of prognosis in @entity1 with @entity463 . METHODS: Forty-seven @entity1 treated with surgery, radiotherapy, and adjuvant chemotherapy between 2005 and 2007 were divided into 2 groups according to @entity28333 expression in an immunohistochemical study: the @entity28333 negative group (n = 12 @entity1 ) and the @entity28333 positive group (n = 35 @entity1 ). The clinicopathologic features and survival data for @entity1 in the @entity28333 positive group were compared with data from the @entity1 in the @entity28333 negative group. Kaplan-Meier survival analysis and univariate and multivariate analyses were performed to determine the prognostic factors that influenced @entity1 survival. RESULTS: @entity28333 positive expression was observed in approximately 74.5% of @entity1 with @entity463 . @entity1 in the @entity28333 positive group had lower overall survival rates and median survival time than those in the @entity28333 negative group (overall 2-year actuarial survival rates, 8.6% for the @entity28333 positive group vs 16.7% for the @entity28333 negative group; overall 2-year median survival time, 12.9 months for the @entity28333 positive group vs 17.9 months for the @entity28333 negative group, P = .019). @entity28333 positive expression in @entity5 cells also was correlated with a shorter interval to @entity5 recurrence (median interval to recurrence, 5.9 months in the @entity28333 positive group vs 8.3 months in the @entity28333 negative group, P = .002). Univariate and multivariate analyses showed that @entity28333 positive expression was an independent prognostic factor. CONCLUSION: @entity28333 positive expression can be used as a potential molecular risk factor in @entity1 with @entity463 .
