Establishment of an Animal Model of @entity5520 -Related @entity2530 of the Jaws in Spontaneously XXXX Torii @entity35 .

@entity5921 @entity5272 @entity6 @entity5520 @entity79 @entity35 @entity4381 @entity2530
BACKGROUND: We evaluated the side effects of @entity5520 (BP) on tooth extraction socket healing in spontaneously @entity6 Torii (SDT) @entity35 , an established model of @entity6 , to develop an animal model of BP-related @entity2530 of the jaws (BRONJ). MATERIALS AND METHODS: Male Sprague-Dawley (SD) @entity35 and SDT @entity35 were randomly assigned to the @entity4381 ( @entity5921 )-treated groups (SD/ @entity5921 or SDT/ @entity5921 ) or to the control groups (SD/control or SDT/control). @entity35 in the SD/ @entity5921 or SDT/ @entity5921 groups received an intravenous bolus injection of @entity5921 (35  g/kg) every 2 weeks. Each group consisted of 6 @entity35 each. Twenty-one weeks after @entity5921 treatment began, the left maxillary molars were extracted. The @entity35 were euthanized at 2, 4, or 8 weeks after tooth extraction, and the total maxillae were harvested for histological and histochemical studies. RESULTS: In the oral cavity, bone exposure persisted at the tooth extraction site in all @entity35 of the SDT/ @entity5921 group until 8 weeks after tooth extraction. In contrast, there was no bone exposure in SD/control or SDT/control groups, and only 1 of 6 @entity35 in the SD/ @entity5921 group showed bone exposure. Histologically, necrotic bone areas with empty lacunae, microbial colonies, and less invasion by inflammatory cells were observed. The number of @entity5272 -resistant acid phosphatase-positive osteoclasts was lower in the SDT/ @entity5921 group than in the SD/control group. The mineral apposition rate was significantly lower in the SDT/ @entity5921 group compared with the SD/control group. CONCLUSIONS: This study demonstrated the development of BRONJ-like lesions in @entity35 and suggested that @entity79 with less inflammatory cell infiltration plays an important role in the development of BRONJ.
