The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in XXXX .

@entity1 @entity0 @entity71488 @entity5 @entity11736 @entity1550 @entity3 @entity1722
UNASSIGNED: Each @entity0 has its unique spatial shape, but the clinical importance and the underlying mechanism for the three-dimensional @entity5 shapes are mostly unknown. We collected the data on the three-dimensional @entity5 size and @entity5 volume data of invasive @entity0 from 2,250 @entity1 who underwent surgery between Jan 2000 and Jul 2007. The degree of @entity5 eccentricity was estimated by using the difference between the spheroid @entity5 volume and ellipsoid @entity5 volume (spheroid-ellipsoid discrepancy, @entity11736 ). In 41 @entity1 , transcriptome and exome sequencing data obtained. Estimation of more accurate @entity5 burden by calculating ellipsoid @entity5 volumes did not improve the outcome prediction when compared to the traditional longest diameter measurement. However, the @entity5 eccentricity, which was measured by @entity11736 , showed significant variation between the molecular subtypes of @entity0 . Additionally, the degree of @entity5 eccentricity was associated with well-known prognostic factors of @entity0 such as @entity5 size and lymph node @entity3 . Transcriptome data from 41 @entity1 showed significant association between @entity1550 and @entity5 shapes. Network analysis and analysis of TCGA gene expression data suggest that @entity1550 is regulated by @entity1722 and @entity71488 . The present study validates the usefulness of the current @entity5 size method in determining @entity5 stages. Furthermore, we show that the @entity5 with high eccentricity are more likely to have aggressive @entity5 characteristics. Genes involved in the extracellular matrix remodeling can be candidate regulators of the @entity5 shapes in @entity0 .
