@entity876 , cellular proliferation, and apoptosis-related XXXX .

@entity589 @entity588 @entity5 @entity1836 @entity2 @entity876 @entity6732 @entity1758
@entity6732 are biologically aggressive @entity5 with extensive local invasion and high mortality. Although various markers of cellular proliferation and apoptosis have correlated with degrees of @entity5 differentiation @entity2 , they have not been systematically studied in thymic @entity5 . We immunostained 21 cases of thymic @entity5 for @entity876 , @entity1758 , and the apoptosis-related markers @entity588 , @entity1836 , and @entity589 . By histological classification the cases were low-grade (nine cases), intermediate-grade (eight cases), and high-grade (four cases) thymic @entity5 . @entity876 was expressed in five cases: 1/9 low grade, 3/8 intermediate grade, and 2/4 high grade. The mean cellular proliferation ( @entity1758 ) was 7.1% (range 2-12%) in @entity6732 , 6.1% (range 2-15%) in intermediate-grade thymic @entity5 , and 34.2% (range 2-80%) in high-grade thymic @entity5 . @entity588 was expressed in 16 cases: 7/9 low grade, 5/8 intermediate grade, and 4/4 high grade. @entity1836 was expressed in 16 cases: 7/9 low grade, 6/8 intermediate grade, and 3/4 high grade. @entity589 was expressed in 13 cases: 5/9 low grade, 4/8 intermediate grade, and 4/4 high grade. The presence of mutant @entity876 in the @entity5 was associated with a statistically significant decreased mean survival (P<0.05). In contrast, either by positive or negative staining or by the score technique (staining intensity x percentage of cells staining), the presence of @entity1836 was associated with an increased mean survival (P<0.05). Finally, a @entity1836 : @entity589 ratio >or=1 was also associated with an increased mean survival, as compared to a @entity1836 : @entity589 ratio >or=1 (P<0.05). Our study shows that @entity876 expression and certain apoptosis markers correlate with survival. The expression of these markers may account for differences in biological behavior.
