Effects of intraplantar nocistatin and (  )-J 113397 injections on nociceptive behavior in a XXXX model of @entity32 .

@entity32 @entity46775 @entity1931 @entity158 @entity26078 @entity35 @entity24661
@entity26078 (NST) and @entity24661 / @entity24661 (N/OFQ) are derived from the same precursor protein, pre-proN/OFQ, and exert opposite effects on the modulation of @entity158 signals. However, the role of the peripheral N/OFQ and the NOP receptor, which is located at the endings of sensory nerves, in @entity158 was not ascertained. NST administered intrathecally (i.t.) prevented the nociceptive effects induced by i.t. N/OFQ and PGE   . Moreover an up regulation of N/OFQ was shown in the @entity35 in response to peripheral @entity32 . Here, we investigated the effects of intraplantar (i.pl.) administration of functional N/OFQ and NOP receptor antagonists in a @entity35 model of @entity158 . Our findings showed that i.pl. injection of (  )- @entity46775 , a selective antagonist of the NOP receptor, and NST, the functional N/OFQ antagonist, prior to carrageenan significantly reduced the paw allodynic and thermal @entity1931 threshold induced by the inflammatory agent. The resulting antiallodynic and antihyperalgesic effects by co-administering NST and (  )-J 113397 prior to carrageenan were markedly enhanced, and the basal latencies were restored. Thus, it is likely that the peripheral N/OFQ/NOP receptor system contributes to the @entity158 sensitivity in an inflammatory state.
