Diffusion tensor imaging reveals XXXX in idiopathic normal pressure hydrocephalus.

@entity1 @entity63 @entity5083 @entity393 @entity62
BACKGROUND: @entity5083 ( @entity5083 ) is associated with @entity62 , but the extent and severity of the lesions do not cohere with symptoms or improvement after shunting, implying the presence of further, yet undisclosed, injuries to white matter in @entity5083 . OBJECTIVE: To apply diffusion tensor imaging (DTI) to explore @entity62 in @entity1 with @entity5083 before and after drainage of cerebrospinal fluid (CSF). METHODS: Eighteen @entity1 and 10 controls were included. DTI was performed in a 1.5T MRI scanner before and after 3-day drainage of 400 mL of CSF. Regions of interest included corpus callosum, capsula interna, frontal and lateral periventricular white matter, and centrum semiovale. White matter integrity was quantified by assessing fractional anisotropies (FA) and apparent diffusion coefficients (ADC), comparing them between @entity1 and controls and between @entity1 before and after drainage. The significance level corresponded to .05 (Bonferroni corrected). RESULTS: @entity393 in @entity1 was found in 3 regions (P<.002, P<.001, and P<.001) in anterior frontal white matter, whereas elevated ADC was found in genu corpus callosum (P<.001) and areas of centrum semiovale associated with the precentral gyri (P<.002). Diffusion patterns in these areas did not change after drainage. CONCLUSION: DTI reveals subtle injuries-interpreted as axonal loss and @entity62 where high-order motor systems between frontal cortex and basal ganglia travel, further supporting the notion that motor symptoms in @entity5083 are caused by a chronic @entity63 to the neuronal systems involved in the planning processes of movements.
