Expression and production of the CXC chemokine growth-related oncogene-alpha by XXXX eosinophils.

@entity1 @entity32 @entity1356 @entity5 @entity310 @entity2851 @entity379 @entity468 @entity7416 @entity978
Eosinophils are seen together with neutrophils at sites of @entity32 . However, their roles are not clear. In addition, eosinophils infiltrate @entity5 tissue in some @entity5 . In this study, we show that large amounts of the neutrophil-activating CXC chemokine growth-related oncogene (GRO)-alpha can be produced by @entity1 eosinophils. Eosinophils showed presence of preformed @entity2851 in the crystalloid-containing specific granules (190 @entity468 x 10(6) cells). During incubation, a strong increase in @entity2851 gene expression was seen. At a low cell density, addition of @entity310 or @entity1356 increased the production of @entity2851 in eosinophils, which was not the case at a higher cell density. Eosinophils can produce @entity310 themselves, and neutralizing Abs against @entity310 significantly inhibited @entity2851 production. This suggests that autocrine and paracrine effects from @entity310 can be important when up-regulating @entity2851 gene expression. In contrast, @entity379 , a prototypic Th1-cytokine, down-regulated expression of @entity2851 . This may be important during resolution of @entity32 but also suggests different roles for eosinophils depending on the inflammatory context. @entity5 eosinophils in @entity978 of the nodular sclerosing type are associated with a poor prognosis. Eosinophils from such @entity5 tissue showed an abundant expression of @entity2851 . The @entity2851 receptor @entity7416 was also detected in @entity5 tissue, proposing interactions between eosinophils and the @entity5 . Our findings suggest that eosinophils can promote @entity32 through recruitment of @entity7416 -bearing cells. In addition, this feature of the eosinophils indicates a role for these cells in the biology of certain @entity5 .
