@entity2332 and hyperbaric XXXX as treatment modalities for severe head injury.

@entity1545 @entity1 @entity131 @entity64 @entity16 @entity26 @entity943 @entity2332
Moderate @entity2332 has been shown to improve neurologic outcomes in both fluid-percussion and @entity131 models of experimental @entity1545 . Based upon initial clinical work, it was concluded that at temperatures < 32 degrees C, @entity1 with severe @entity1545 were at increased risk of @entity943 , and that rapid rewarming immediately postinjury predisposed to intracranial pressure increases. Subsequent clinical studies of moderate @entity2332 (32 degrees C) for 24- to 48-hr duration with slow rewarming in @entity1 @entity1545 showed indications of neurologic improvement and a low incidence of @entity2332 -related complications. Based upon the strengths of both laboratory and clinical data, a multicenter (nine centers), randomized, prospective trial testing moderate @entity2332 in @entity1 with severe @entity1545 has been organized. This trial, funded by National Institutes of Health, National Institute of @entity16 and @entity64 , began on October 20, 1994. Five hundred @entity1 are to be treated in an intent-to-treat protocol using standard management at normothermia versus standard management at @entity2332 . The trial is designed to detect an absolute shift of 12% in the percentage of @entity1 achieving satisfactory outcome (good recovery/moderate disability) at a power of 85% at 6 months postinjury. The efficacy of hyperbaric @entity26 administered every 8 hrs for 1-hr duration for a 2-wk period has also been tested in @entity1 after severe @entity1545 . While the mortality rate was reduced in the treated group, the percentage of favorable outcomes was unchanged. Further studies are in progress.
