Primary immune response to Helix pomatia haemocyanin in XXXX . Relationship between 19S and 7S antibody response and in vitro lymphocyte transformation.

@entity1 @entity66 @entity5 @entity73 @entity1442 @entity116 @entity320
The primary immune response to Helix pamatia haemocyanin (HPH) was investigated in sixty-one @entity1 with various clinical signs of @entity320 and compared to that of controls. Anti-HPH antibody response was only found abnormal in @entity1 with @entity66 and visceral metastases, apparent from decreased 7S and increased 19S antibody levels. In vitro HPH-induced lymphocyte transformation, in contrast, was not only decreased in this late stage, but also in part of the @entity1 in the beginning of the disease and was then correlated with subsequent @entity5 recurrence within 6 months. Generally, @entity1 with positive lymphocyte transformation showed significantly higher 7S anti-HPH titres (mean 3-3 +/- 2-4 than @entity1 without (1-7 +/- 1-6). In contrast to the lymphocyte transformation reaction, anti-HPH antibody response was not correlated with subsequent @entity5 recurrence. The same phenomenon of decreased 7S and increased 19S antibody response as in the @entity320 @entity1 with @entity1442 was observed to a less extent in controls with ageing. Anamnestic antibody responses to diphtheria and @entity116 toxoid and serum IgG and IgA levels were found normal. Elevated serum IgM levels were more frequently observed in @entity1 with localized (19/31) and disseminated disease (11/29) than in controls (2/31). These results suggest that @entity320 @entity1 develop @entity73 in final stages with visceral metastases. A previous study showed that minor defects in lymphocyte function in an early stage as measured by HPH-induced lymphocyte transformation have predictive value for subsequent @entity5 recurrence.
