@entity22210 Genetic Variation Confers Risk to XXXX .

@entity1 @entity162 @entity22210 @entity22211 @entity72088 @entity2403
UNASSIGNED: Genetic variation in the gene encoding @entity22210 gene ( @entity22210 ) has been identified to be associated with @entity162 in genome-wide association studies, while little is known regarding their association in Asian populations. In this study, we aimed to examine whether @entity22210 may confer susceptibility to @entity2403 in Han Chinese. We measured the mRNA expression level of @entity22210 in @entity1 with @entity2403 and controls. Two functional variants ( @entity22211 and @entity72088 ) in @entity22210 were genotyped among 1508 individuals with or without @entity2403 . We then performed a meta-analysis based on present literature. Our results showed that @entity22210 mRNA level in peripheral blood mononuclear cells was significantly higher in @entity2403 @entity1 than that in controls (P   =   0.01). The @entity22211 showed significant allelic association with @entity2403 (P   =   0.034). The frequency of T allele of @entity22211 was higher in @entity1 than that in controls (odds ratio   =   1.19, 95  % confidence interval 1.03-1.37). After pooling all data, meta-analysis indicated a significant association of @entity22211 with @entity2403 (P   =   0.0003). Furthermore, we performed an eQTL analysis and observed significant associations between @entity22211 and @entity22210 expression level in hippocampus (P   =   0.032) and occipital cortex (P   =   0.036). After stratified by diagnosis, the association of @entity22211 with @entity2403 was only survived in @entity2403 -I (genotypic P   =   0.04, allelic P   =   0.014), but not in @entity2403 -II. Our findings provided supportive evidence for the involvement of @entity22210 @entity22211 in @entity2403 , especially in @entity2403 -I.
