[Difficult transitions from paediatric to adult care in type 1 XXXX ].

@entity2315 @entity1 @entity16 @entity102 @entity1503 @entity1120
@entity1120 is the most frequent @entity2315 . It is a progressive @entity102 that can lead to substantial bone and joint @entity1503 . This progressive disease severely worsens the @entity1 ' quality of life. Over the past 20 years, enzymatic treatment has considerably improved both symptoms and quality of life. Yet, bone and @entity16 may be irreversible. This emphasizes the importance of rigorous follow-up so as to begin uninterrupted treatment before lesion onset. The transition from pediatric to adult care is a major concern for chronic @entity1 . This step is often associated with follow-up problems and may lead to disease worsening. We present three cases of @entity1 who were lost to follow-up during the transition phase. For all 3 @entity1 , the disease notably worsened because follow-up was interrupted during this period.
