A Comprehensive Study of Extramural @entity3 in XXXX .

@entity1 @entity5 @entity3 @entity14 @entity204
UNASSIGNED: @entity14 is a common @entity5 and a leading cause of @entity5 related @entity204 . @entity5 staging following resection is key to determining any adjuvant therapy in those @entity1 with high risk disease. In @entity14 , @entity5 stage and lymph node stage are the main pathological factors which have been considered to influence outcome. Increasing emphasis is now being placed on other factors, especially the presence of extramural @entity3 (EMVI). It is important to understand the relationship of EMVI with other pathological factors and to confirm that in an individual centre that EMVI is being detected at an appropriate rate and is of prognostic significance. This comprehensive study assesses the reporting and prognostic significance of EMVI in a single centre, using prospectively collected data from histopathology reports of a cohort of 2405 @entity1 who underwent surgery for @entity14 over a nine year period. Overall, EMVI was reported in 27.9% of @entity14 excision specimens. In @entity5 (n = 1928) that had not received neoadjuvant therapy, the presence of EMVI varied significantly depending on @entity5 site (  2 = 12.03, p<0.005), @entity5 stage (  2 = 268.188, p<0.001), lymph node stage (  2 = 294.368, p<0.001) and Dukes' stage (  2 = 253.753, p<0.001). Multivariate analysis confirmed EMVI as a significant independent prognostic indicator (p<0.001). In conclusion, the presence of EMVI as an independent prognostic indicator is shown and is related to other pathological and prognostic factors. This study emphasises the requirement for the accurate identification of EMVI in @entity14 excision specimens and also understanding the relationship of EMVI with other prognostic factors.
