The Association between Multisite Near-Infrared Spectroscopy and Routine Hemodynamic Measurements in Relation to Short-Term Outcome in Preterms with XXXX .

@entity1 @entity1457 @entity26 @entity922
BACKGROUND: The added clinical value of multisite near-infrared spectroscopy (NIRS) monitoring to detect low organ tissue perfusion in preterm @entity1 at risk of @entity1457 remains unclear. OBJECTIVES: To evaluate the associations between multisite NIRS measurements and clinical signs of @entity1457 in relation to short-term outcome in preterm @entity1 with @entity922 . METHODS: Prospective cohort study of preterm @entity1 (gestational age <32 weeks) with @entity922 . We monitored cerebral, renal, and intestinal @entity26 saturation using NIRS for 72 h following sepsis workup and calculated fractional tissue @entity26 extraction (FTOE). We recorded clinical signs of @entity1457 every 8 h. We analyzed the associations between FTOE values, clinical signs of @entity1457 , and short-term outcome. RESULTS: In 28 preterm @entity1 with @entity922 , intraindividual and interindividual associations between NIRS values and clinical signs of @entity1457 were weak. At several points of time during the study period, cerebral and renal FTOE were higher in @entity1 who developed intestinal complications compared with @entity1 who did not, while clinical signs of @entity1457 never differed between groups. After correcting for multiple testing, significant differences disappeared. CONCLUSIONS: The associations between multisite FTOE values and clinical signs of @entity1457 were weak in preterm @entity1 with @entity922 . Nevertheless, in contrast to clinical signs of @entity1457 , cerebral and renal FTOE values were associated with adverse short-term intestinal outcome in the uncorrected analyses. Multisite NIRS monitoring might help to detect critically low tissue @entity26 delivery leading to adverse intestinal outcome not detected by routine hemodynamic measurements.
