General quality of life 2 years following treatment for XXXX : what influences outcomes? Results from the @entity263 outcomes study.

@entity1 @entity323 @entity263 @entity1973 @entity458 @entity2357 @entity250
PURPOSE: The goal of this study was to determine the relationship between primary treatment, @entity1973 , @entity250 , and general health-related quality of life (HRQOL) in @entity263 . METHODS: A sample of @entity1 with newly diagnosed @entity263 between 1994 and 1995 was randomly selected from six population-based Surveillance, Epidemiology, and End Results registries. A baseline survey was completed by 2,306 @entity1 within 6 to 12 months of diagnosis, and these @entity1 also completed a follow-up HRQOL survey 2 years after diagnosis. @entity2357 models were used to determine whether primary treatment, @entity1973 , and @entity250 were independently associated with general HRQOL outcomes approximately 2 years after diagnosis as measured by the Medical Outcomes Study 36-item Short Form Health Survey. The magnitude of this effect was estimated using least square means models. RESULTS: After adjustment for potential confounders, primary treatment was not associated with 2-year general HRQOL outcomes in @entity1 with @entity263 . Urinary function and bother were independently associated with worse general HRQOL in all domains. Sexual function and bother were also independently associated with worse general HRQOL, although the relationship was not as strong as in the urinary domains. CONCLUSION: Primary treatment is not associated with 2-year general HRQOL outcomes in @entity263 . Although both @entity458 and bother are associated with quality of life, @entity1 who are more bothered by their urination or @entity323 are more likely to report worse quality of life. This implies that future research should be directed toward finding ways to improve treatment-related outcomes or help @entity1 better cope with their posttreatment urinary or @entity250 .
