The impact of @entity15461 gene polymorphisms on XXXX .

@entity1 @entity28739 @entity28392 @entity15461 @entity72275 @entity53389 @entity460 @entity3151 @entity1791
OBJECTIVES: To investigate the effect of @entity15461 gene and b-glucuronidase activity on stone formation in @entity1 with @entity28739 ( @entity28739 ). METHODS: A total of 103 @entity1 with @entity28739 and 102 controls with no specific @entity1791 history were enrolled into the study. @entity28392 and @entity53389 polymorphisms of @entity15461 gene were analyzed with PCR method. Serum levels of @entity460 and @entity3151 and 24-h urine levels of b-glucuronidase activity, @entity460 and @entity3151 levels were measured biochemically. RESULTS: A total of 103 of @entity1 were male (50.2  %) and 102 were female (49.8  %) (p 0.945). Twenty-four-hour urine levels of @entity460 were significantly higher in @entity28739 group, whereas no difference was observed in @entity3151 levels (p  <  0.001, p 0.074, respectively). As for the @entity28392 polymorphism, type of GG was significantly higher in the @entity1 group compared to the controls (p  =  0.02), while GA genotype was significantly higher in the controls (p  =  0.001). There was no significant difference in @entity72275 and @entity53389 polymorphism between the @entity1 and control groups. b-glucuronidase activity was slightly lower in the @entity1 group without significance (p 0.932).When @entity1 with GG genotype and the rest were compared, there were no significant difference in all parameters. CONCLUSIONS: Any polymorphism altering the function of @entity15461 gene may result with stone formation. We found that there are more GG sequences of @entity28392 gene in @entity1 with @entity28739 . That may be a polymorphism of @entity15461 gene which results with stone formation. Further studies with more @entity1 should be accomplished which are combining the genetic and epigenetic factors associated with @entity1791 and @entity15461 gene to enlighten the etiology of this disease.
