XXXX surgery and the 5-year incidence of late-stage age-related @entity1020 : pooled findings from the Beaver Dam and Blue Mountains eye studies.

@entity1 @entity66 @entity231 @entity10691 @entity1020
PURPOSE: To assess whether @entity231 surgery in older @entity1 increases risk for the development of late-stage age-related @entity1020 (ARM). DESIGN: Combined analysis of longitudinal data from two population-based cohorts, the Beaver Dam Eye Study and Blue Mountains Eye Study. @entity1 : The Beaver Dam Eye Study examined 4926 @entity1 aged 43 years or older at baseline and re-examined 3684 after 5 years. The Blue Mountains Eye Study examined 3654 @entity1 aged 49 years or older at baseline and re-examined 2335 after 5 years. METHODS: The two studies used similar protocols for retinal photography and photographic grading. We defined incident late-stage ARM as the development of @entity1020 or @entity10691 without either lesion type at baseline that was confirmed by consensus between the study investigators. Nonphakic eyes included eyes that were aphakic or pseudophakic at baseline. Eye-specific data were analyzed. Age- and study site-adjusted relative risks were calculated using the Cochran-Mantel-Haenszel method. Multivariate-adjusted odds ratios (ORs) were also estimated using generalized estimating equation models. RESULTS: Of the 6019 @entity1 examined after 5 years, 11,391 eyes were considered at risk for developing late-stage ARM, including 315 nonphakic and 11,076 phakic eyes. Late-state ARM (either @entity1020 or @entity10691 ) developed in 6.0% to 7.5% of nonphakic eyes (10 of 168 right and 11 of 147 left eyes), compared with 0.7% of phakic eyes (40 of 5504 right and 37 of 5572 left eyes) during the 5-year period. Age- and study site-adjusted 5-year relative risks were 2.8 (95% confidence interval [CI], 1.6-5.1) for right and 3.7 (95% CI, 2.1-6.4) for left eyes. After further adjustment for gender, smoking, and the presence of indistinct or reticular drusen or @entity66 at baseline, nonphakic eyes had a substantially higher risk for developing either late-stage ARM lesion compared with phakic eyes, OR = 5.7 (95% CI, 2.4-13.6). CONCLUSIONS: Pooled findings from these two large population-based cohorts support the hypothesis that @entity231 surgery in older @entity1 may be associated with an increased subsequent risk for developing late-stage ARM, particularly @entity1020 .
