Transbronchial biopsy interpretation in the XXXX with diffuse parenchymal lung disease.

@entity1 @entity455 @entity548 @entity1222 @entity5930 @entity3616 @entity358 @entity3008 @entity5970 @entity2883 @entity370 @entity647
CONTEXT: The most common lung tissue samples seen by pathologists worldwide are obtained with the flexible bronchoscope. Specimens taken for examination of diffuse or multifocal @entity358 pose special challenges for the general surgical pathologist, and these challenges are often compounded by high clinical expectations for accurate and specific diagnosis. OBJECTIVE: To present and discuss the most common histopathologic patterns and diagnostic entities seen in transbronchial biopsy specimens in the setting of diffuse or multifocal @entity358 . Specifically, @entity647 , @entity5930 , @entity548 , chronic cellular infiltrates, @entity3616 , @entity5970 , @entity370 , Wegener @entity2883 , intravenous drug abuse-related @entity455 , @entity1222 , and @entity3008 are presented. Clinical and radiologic context is provided for the more specific diagnostic entities. DATA SOURCES: The published literature and experience from a consultation practice. CONCLUSIONS: The transbronchial biopsy specimen can provide valuable information for clinical management in the setting of diffuse or multifocal @entity358 . Computed tomographic scans are useful for selecting appropriate @entity1 to undergo biopsy and in limiting the differential diagnosis. Knowledge of the clinical context, radiologic distribution of abnormalities, and histopathologic patterns is essential. With this information, the surgical pathologist can substantially influence the diagnostic workup and help guide the clinician to an accurate clinical/radiologic/pathologic diagnosis.
