XXXX in primary pulmonary marginal zone @entity1892 .

@entity1 @entity19592 @entity527 @entity2783 @entity5 @entity1074 @entity1582 @entity1892 @entity309
A rare association between primary pulmonary marginal zone @entity1892 ( @entity1074 ), and pulmonary immunoglobulin light chain ( @entity1582 ) @entity2783 is described in a 65-year-old @entity1 suffering from @entity309 ( @entity309 ). All four nodules in the resected upper lobe of the lung had a similar histological appearance. They were composed of small-medium-sized atypical lymphocytes. Centrocyte-like cells had lymphoepithelial lesions. Immunohistochemically, the @entity5 cells clonally expressed B-cell markers, and demonstrated clonal rearrangement of the immunoglobulin heavy chain gene on polymerase chain reaction. Based on these findings the diagnosis of primary @entity1074 was made. In addition, uniform eosinophilic material deposition was identified randomly within the @entity5 . It was Congophilic and exhibited apple-green birefringence on polarizing microscopy, and remained unaffected by @entity19592 digestion. Deposited material was immunoreactive to lambda light chain. It was concluded that this material was @entity1582 amyloid in primary @entity1074 . Plasma cells with mRNA of lambda chain was found infiltrated along the border of @entity527 . Finally, it is speculated that primary @entity1074 developing in an autoimmune setting, @entity309 in the present case, is associated with overproduction and abnormal clearance of immunoglobulin by the @entity5 cells, resulting in @entity5 .
