XXXX @entity71080 expression in normal tissues: an immunohistochemical study.

@entity1 @entity71080 @entity1885 @entity22546 @entity7435 @entity7199 @entity7434
The @entity1 tissue @entity71080 gene ( @entity71080 ), encoding for @entity7435 protein, was recently cloned and characterized. Here we describe the immunohistochemical (IHC) localization of @entity7435 in normal @entity1 tissues and compare it with the expression of two other kallikreins, @entity22546 and @entity7434 . We performed the streptavidin- @entity1885 IHC method on 204 paraffin blocks from archival, current, and autopsy material prepared from almost every normal @entity1 tissue, using a polyclonal and a monoclonal @entity7435 antibody. The staining was cytoplasmic and both antibodies yielded similar results. The @entity7435 protein was revealed in a variety of tissues, mainly in glandular epithelia. Other epithelia that expressed @entity7435 included the urothelium, the spermatic epithelium, and the epithelium of the choroid plexus. @entity7435 was intensely immunoexpressed by some endocrine organs, such as the adenohypophysis, the thyroid gland, the parathyroid glands, the adrenal medulla, the Leydig cells of the testis, and the cells of the endocrine pancreas. Immunoreactivity was also observed in the primordial follicles, the corpus luteum, and sparse luteinized cells in the stroma of the ovary, the trophoblastic cells of the placenta, the Hassall's corpuscles of the thymus, and chondrocytes. Nerves and ganglia of the peripheral nervous system, and both neurons and glial cells in the central nervous system, were positive. In short, @entity7435 was expressed by many glandular epithelia, some endocrine organs, and some specialized epithelia and cells. Comparison of these data with @entity22546 and @entity7434 expression suggests that the three @entity7199 have a similar IHC pattern in normal @entity1 tissues.
