Clara cell protein in bronchoalveolar lavage fluid: a predictor of XXXX ?

@entity1 @entity10974 @entity2489 @entity358 @entity3257 @entity288
INTRODUCTION: @entity10974 ( @entity10974 ) has been associated with inflammatory and infectious @entity358 . This study evaluates @entity10974 concentrations in bronchoalveolar lavage (BAL) fluid as a potential marker of @entity2489 ( @entity3257 ). METHODS: Between January 2003 and December 2007, BAL fluid samples obtained from critically ill @entity1 at the intensive care unit of the Maastricht University Medical Centre clinically suspected of having @entity3257 were included. @entity1 were divided into two groups: (1) microbiologically confirmed @entity3257 (the @entity3257 group) and (2) microbiologically unconfirmed @entity3257 (the @entity3257 ). The concentration of @entity10974 was measured by means of a commercially available enzyme-linked immunosorbent assay kit, and retrospective analysis was performed. Areas under the curve of receiver operating characteristic curves were calculated for @entity10974 concentrations. RESULTS: A total of 196 @entity1 (122 @entity1 , 74 @entity1 ) were included. A total of 79 (40%) of 196 cases of suspected @entity3257 were microbiologically confirmed. The median @entity10974 concentration in the @entity3257 group was 3,019 ng/mL (range, 282 to 65,546 ng/mL) versus 2,504 ng/mL (range, 62 to 30,240 ng/mL) in the @entity3257 (P = 0.03). There was no significant difference in @entity10974 concentrations between @entity1 treated with or without @entity288 (P = 0.26) or antibiotic therapy (P = 0.9). The @entity10974 concentration did not differ significantly between @entity1 with Gram-positive versus Gram-negative bacteria that caused the @entity3257 (P = 0.06). However, @entity10974 concentrations did differ significantly between the late-onset @entity3257 group and the @entity3257 . CONCLUSIONS: The @entity10974 concentration in BAL fluid yielded low diagnostic accuracy in confirming the presence of @entity3257 .
