Evaluating pulsatile ocular blood flow analysis in normal and treated XXXX .

@entity1 @entity735 @entity227 @entity726
PURPOSE: To evaluate pulsatile ocular blood flow (POBF) analysis in normal subjects and @entity726 @entity1 by comparison of POBF measurements with functional (as determined by @entity227 [ @entity227 ]) and structural (as determined by optical coherence tomography [OCT]) measures. DESIGN: Prospective, cross-sectional study. METHODS: Forty-one eyes of 24 consecutive @entity726 @entity1 and 20 eyes of 10 healthy subjects were studied; POBF analysis was performed on all subjects at the same visit as @entity227 testing and OCT retinal nerve fiber layer (NFL) thickness measurement. The mean results of normal and @entity735 were compared for each method. Correlation between measurements obtained with each modality and the discriminating power using receiver operator characteristic curves was tested. RESULTS: The mean POBF (standard deviation [SD]) in the normal group was 1,010.4 (292.8) microl/min and 989.3 (305.5) microl/min in the @entity726 group (P =.90). Significant differences between groups were found for @entity227 mean deviation and pattern standard deviation (P =.02, P =.004, respectively) and OCT mean NFL thickness (P <.0001). No correlation was found between POBF parameters and intraocular pressure, @entity227 , or OCT variables except for intraocular pressure in @entity726 group (r = -.43, P =.003). The area under the receiver operator characteristic curves was higher for @entity227 indexes and OCT mean NFL thickness than POBF parameters for distinguishing between normal and @entity735 . CONCLUSIONS: The wide range of normal values and the low discriminating power of POBF between normal and @entity735 limits the clinical use of the device for @entity726 @entity1 .
