Comparison Between the Effects of Intravenous XXXX , @entity1340 , and @entity6058 on Stress and Immune Responses in @entity1 Undergoing Modified Radical Mastectomy.

@entity1 @entity1340 @entity2940 @entity404 @entity6058 @entity701 @entity1286 @entity405
OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity1286 , @entity1340 , and @entity6058 on stress and immune responses in @entity1 who underwent modified radical mastectomy. @entity1 : Sixty @entity1 randomly assigned to receive IV @entity1286 5 mg (group M, n=20), @entity1340 100 mg (group T, n=20), or @entity6058 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity701 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity2940 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity701 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity404 , @entity405 , and @entity2940 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity404 , @entity405 , and @entity2940 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity405 , and @entity2940 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity404 , and @entity405 decreased in group M compared with group T (P <=0.048) and @entity404 and @entity2940 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity1286 , @entity1340 , and @entity6058 suppressed stress and immune responses. @entity6058 was the least immunosuppressive among the 3 drugs.
