Blood pressure-independent factors determine the susceptibility to delayed XXXX in the @entity64 -prone spontaneously @entity101 @entity35 .

@entity64 @entity101 @entity1249 @entity63 @entity35 @entity528
The @entity64 -prone spontaneously @entity101 @entity35 (SHRSP) is vulnerable to delayed @entity528 (DND) in the @entity1249 subfield of the hippocampus after the transient @entity63 by the occlusion of the bilateral carotid arteries. The present study was designed to show that the genetic factors independent of @entity101 contributed to the high incidence of DND in SHRSP. Male @entity35 of the four strains, SHRSP/Izm, SHRSP/Ngsk, SHR/Izm and a congenic strain for the blood pressure quantitative trait locus on chromosome 1 [SHRSP.WKY-(D1Wox29-D1Arb21)/Izm]were used in the experiments. At 13 weeks of age, the bilateral carotid arteries of @entity35 were occluded for 10 min under anesthesia with their body temperature kept at 37 degreeC. Seven days after the transient @entity63 , the loss of the pyramidal cells in the @entity1249 was evaluated histologically. In some experiments, the blood flow was monitored with a laser Doppler flowmeter during the transient @entity63 . The blood pressure in SHRSP/Izm was significantly greater than that in the other three strains. The incidence of DND, however, was not significantly different among SHRSP/Izm, SHRSP/Ngsk and the congenic strain (82, 74 and 65%, respectively), while SHR/Izm showed a significantly lower incidence (20 percent). Neither a significant correlation between the incidence of DND and the blood flow reduction during the occlusion, nor a significant inter-strain difference in the blood flow reduction was observed. The genetic factors independent of @entity101 may contribute to the greater susceptibility to DND in SHRSP.
