Function, mass, and replication of porcine and @entity35 islets transplanted into @entity6 XXXX .

@entity1 @entity6 @entity19 @entity3839 @entity35 @entity369 @entity413
Well-characterized aliquots of adult porcine and @entity35 islets of comparable beta-cell mass were transplanted under the kidney capsule of @entity3839 -induced @entity6 @entity19 . In both porcine and @entity35 islet grafts, beta-cell mass decreased significantly in the first 2 months and stabilized thereafter. As with beta-cell mass, insulin content decreased significantly in the first 2 months to almost 40% of that originally implanted. In porcine grafts, however, insulin content at 4 months was significantly higher than at 2 months. The endocrine non-beta-cell mass of grafts also decreased significantly after transplantation: in porcine grafts, the decrease was less than in @entity35 and was limited to the first 2 months. beta-cell replication of engrafted islets was significantly lower in porcine than in @entity35 grafts. Although beta-cell mass of porcine and @entity35 grafts was similar at all time periods, recipients of porcine islets required a significantly longer time to reach normal @entity413 levels; nonetheless, their blood @entity413 levels continued to decrease and stabilized at levels significantly lower than those of normal @entity19 . During oral and intraperitoneal @entity413 tolerance tests, blood @entity413 increased only slightly in both the recipients of porcine and @entity35 grafts. When graft-bearing kidneys were perfused in situ, porcine islet grafts showed a 20-fold increase in insulin release in response to both @entity413 and @entity369 . In conclusion, this evidence that adult porcine islet grafts can bring @entity413 levels to those that are normal for @entity1 provides further support of their potential for @entity1 islet replacement therapy.
