Antihypertensive treatment in early postnatal life modulates prenatal dietary influences upon blood pressure in the XXXX .

@entity1 @entity101 @entity1808 @entity3371 @entity9886 @entity1129 @entity594 @entity35 @entity65
Epidemiological evidence from diverse @entity1 populations, supported by experimental evidence from animal models, suggests that maternal nutrition during pregnancy is an important fetal programming influence upon @entity65 . Experiments with a low-protein-diet model of @entity35 pregnancy suggest a role for the renin-angiotensin system in the programming mechanism, since fetal undernutrition permanently elevates pulmonary and plasma angiotensin-converting enzyme activity. Long-term beneficial effects of @entity3371 on blood pressure in this model require further investigation in order to clarify the role of @entity1808 . Pregnant @entity35 were fed a control diet containing 18% (w/w) casein as the protein source or a low-protein diet containing 9% (w/w) casein. Between the ages of 2 and 4 weeks postnatally, mothers and their pups were treated with @entity9886 or @entity594 . All pups in the study had blood pressure determined at 4 and 12 weeks of age using a tail cuff. Animals exposed to the low-protein diet in utero and not subjected to drug treatment had elevated blood pressure relative to control @entity35 (mean increase of 27 mmHg; P<0.001). Treatment of @entity35 exposed to the control diet in utero with either @entity594 or @entity9886 between 2 and 4 weeks of age did not alter their blood pressure. @entity594 had no effect upon the blood pressure of low-protein-exposed pups, but @entity9886 prevented the blood pressure elevation in these animals. Between 4 and 12 weeks of age, blood pressure increased significantly in all groups (P<0.001). The pattern of blood pressure among the groups was identical to that observed at 4 weeks, suggesting that the observed early effects of @entity9886 would be maintained into adult life. The data are consistent with the hypothesis that @entity1808 plays a major role in the prenatal programming of @entity101 . The action of @entity1808 at the @entity1129 (1) receptor between 2 and 4 weeks of age may be critically up-regulated by fetal factors, including exposure to glucocorticoids of maternal origin.
