Asymptomatic XXXX : clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry.

@entity1 @entity712 @entity117 @entity740 @entity1031 @entity955 @entity583
OBJECTIVE: @entity955 is often asymptomatic, but outcomes require further characterization. The study objective was to investigate the clinical presentation, management, and outcomes in asymptomatic and symptomatic @entity1 with @entity955 who were prospectively enrolled in the EurObservational Research Programme - Atrial Fibrillation (EORP-AF) Pilot General Registry. METHODS: A total of 3119 @entity1 were enrolled, and 1237 (39.7%) were asymptomatic (European Heart Rhythm Association [EHRA] score I). Among symptomatic @entity1 , 963 (51.2%) had mild symptoms (EHRA score II) and 919 (48.8%) had severe or disabling symptoms (EHRA III-IV). Permanent @entity955 was 3-fold more common in asymptomatic @entity1 than in symptomatic @entity1 . RESULTS: On multivariate analysis, male gender (odds ratio [OR], 1.630; 95% confidence interval [CI], 1.384-1.921), older age (OR, 1.019; 95% CI, 1.012-1.026), previous @entity583 (OR, 1.681; 95% CI, 1.350-2.093), and limited physical activity (OR, 1.757; 95% CI, 1.495-2.064) were associated significantly with asymptomatic (EHRA I) @entity955 . Fully asymptomatic @entity955 (absence of current and previous symptoms) was present in 520 @entity1 (16.7%) and was associated independently with male gender, age, and previous @entity583 . Appropriate guideline-based prescription of oral anticoagulants was lower in these @entity1 , and @entity117 was prescribed more frequently. Mortality at 1 year was more than 2-fold higher in asymptomatic @entity1 compared with symptomatic @entity1 (9.4% vs 4.2%, P < .0001) and was associated independently with older age and comorbidities, including @entity740 and @entity712 . CONCLUSIONS: Asymptomatic @entity955 is common in daily cardiology practice and is associated with elderly age, more comorbidities, and high @entity1031 risks. A higher 1-year mortality was found in asymptomatic @entity1 compared with symptomatic @entity1 .
