Evaluation of Japanese practice guidelines for newly diagnosed childhood XXXX .

@entity1 @entity3039
BACKGROUND: Practice guidelines for childhood @entity3039 ( @entity3039 ) were proposed in 1998 and 2004 in Japan. It is important to evaluate the feasibility and validity of the guidelines because the guidelines are based not on evidence but on opinion. METHODS: Records of 30 consecutive hospitalized @entity1 aged 0-15 years (median, 3 years; 17 @entity1 , 13 @entity1 ) were retrospectively reviewed. The feasibility and validity of the 2004 guidelines were evaluated by calculating an implementation rate, a response rate to first treatments, and a final clinical outcome. RESULTS: Deviation from the guidelines was found in two @entity1 . Management of the other 28 @entity1 followed the guidelines. The implementation rate was 93.3%. Twenty-one of the 28 eligible @entity1 (75%) responded to the first treatment, whereas seven @entity1 (25%) required additional treatment. In 23 @entity1 (76.7%) platelet counts returned to normal within 6 months. Seven @entity1 (23.3%) developed chronic conditions. All @entity1 had no complications and achieved a platelet count >150 000/  L within 6 years. CONCLUSION: The 2004 Japanese guidelines are feasible and valid for the management of newly diagnosed childhood @entity3039 @entity1 .
