Lipoprotein metabolism in XXXX in childhood.

@entity1 @entity1674 @entity755 @entity412 @entity5522 @entity1985 @entity165
In nine @entity1 with @entity1985 ( @entity1985 ), significant negative correlations were shown between plasma albumin and @entity165 (r=-0.85, p less than 0.005) and between plasma albumin and low density lipoprotein (LDL)-apoprotein B ( @entity755 ) (r=-0.84, p less than 0.005), whereas there was no such correlation in ten matched ntrol @entity1 . LDL- @entity755 (182.8 +/141.2 MG/DL), @entity165 (249.3 +/-190.2 mg/dl) and @entity1674 (40.8 +/- 23.5 mg/dl) were all elevated above controls. Control values: LDL- @entity755 : 75.4 +/-25.0 mg/dl, - @entity165 : ll9.3 +/-27.6 mg/dl and - @entity1674 : 29.2-17.9 mg/dl. The @entity1 with @entity1985 also exhibited a negative correlation between plasma @entity412 levels and plasma lipoprotein lipaseactiveiy (r=-0.79, p less than 0.02), which was not observed in controls. The hepatic triglycerice lipase (H-TGL) showed a mean activity of 22.2 +/- 10.7 mumol/ml FFA, which was not different form the control value of 21.2 +/-3.9 mumol/ml FFA. Not only LDL- @entity165 values were elevated in the @entity1 with @entity1985 , but high density lipoprotein (HDL)- @entity165 as well. HDL- @entity165 in @entity1985 : 68.6 +/- 29.0 mg/dl, controls: 45.7 +/- 8.5 mg/dl. Twelve @entity1 with @entity1985 in remission showed no correlation between plasma albumin and @entity165 and plasma albumin and LDL- @entity755 respectively. The concentrations of LDL- @entity755 (92.2 +/- 24.5 mg/dl),- @entity165 (121.7 +/- 37.1 mg/dl) and - @entity1674 (28.9 +/-18.9 mg/dl) were within the normal range. No significan correlation was found between plasma @entity412 levels and plasma lipoprotein lipase activity (r=0.38, p greater than 0.2), and H-TGL activity, at 24.1 +/-9.3 mumol/ml FFA, was not different from control. In contrast to the complete normalization of LDL- @entity165 level, the HDL- @entity165 level remained slightly above control (HDL- @entity165 : 57.0 +/- 17.6 mg/dl). The hyperlipoproteinaemia in @entity1985 represents a combination of an increasents a combination of an increased hepatic lipoprotein synthesis and a decreased catabolism of @entity412 rich lipoproteins as indicated by an insufficiency of the lipoprotein lipase. The simultaneous elevation of LDL- and HDL- @entity165 suggests at most a moderate degree of atherogeneity of the @entity5522 in @entity1985 .
