Comparison of Salivary XXXX Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy.

@entity1 @entity2520 @entity2522 @entity2843 @entity2521
Background. @entity2520 is a chronic inflammatory condition affecting the supporting structures of the dentition. Periodontal destruction is an outcome of the imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs). We wanted to prove the hypothesis that salivary TIPM-1 level will vary in different @entity1 . A decrease in @entity2843 level could make them more susceptible to @entity2521 whereas a normal level could prevent increased tissue destruction thereby inhibiting the progression from @entity2522 to @entity2521 . This could probably pave the way for TIPM-1 to be a specific salivary biomarker and serve as a useful diagnostic and therapeutic tool in @entity2521 . Methods. Whole unstimulated saliva of 2   ml was collected from twenty-five periodontally healthy and twenty-seven systemically healthy subjects with @entity2521 . Clinical parameters recorded at baseline and reevaluated after four weeks in subjects with @entity2521 following nonsurgical periodontal therapy were gingival index (GI), oral hygiene index-Simplified (OHI-S), probing pocket depth, and clinical attachment level (CAL). Salivary @entity2843 levels in both were analyzed using a commercially available ELISA kit.
