Changes in the myocardial performance index during XXXX administration in anesthetized @entity468 .

@entity1 @entity64 @entity452 @entity450 @entity1875 @entity5161 @entity468 @entity1002
OBJECTIVE: To investigate the relationship between myocardial performance index (MPI; also known as the Tei index) and cardiac function in anesthetized @entity468 administered @entity452 . ANIMALS: 6 adult @entity468 . PROCEDURES: @entity468 were anesthetized by administration of @entity1875 (6 mg/kg, IV), and anesthesia was maintained by administration of @entity5161 . Heart rate and systolic arterial pressure (SAP) were monitored. @entity64 volume, cardiac output, and @entity450 ( @entity450 ) were measured by use of transesophageal ultrasonography. @entity1002 ( @entity1002 ), mitral E-wave velocity-to-A-wave velocity (E:A) ratio, and ejection time were measured by use of transthoracic echocardiography. @entity452 was administrated via a cephalic vein at rates of 2.5, 5.0, and 10 microg/kg/min. RESULTS: Heart rate, SAP, cardiac output, and @entity450 increased with @entity452 administration, whereas @entity64 volume significantly decreased. The @entity1002 significantly increased, and the E:A ratio significantly decreased. Total isovolumic time and the MPI significantly decreased. The MPI was negatively correlated (r=-0.63) with @entity1002 . Conversely, the MPI was positively correlated with the E:A ratio (r=0.47), @entity64 volume (r=0.66), and total isovolumic time (r=0.95). However, the MPI was not significantly correlated with heart rate, SAP, cardiac output, or @entity450 . CONCLUSION AND CLINICAL RELEVANCE: Analysis suggested that the MPI provides a sensitive clinical assessment of cardiac response to medication in @entity468 , which may be similar to the usefulness of the MPI reported in @entity1 .
