Multimodal therapy in XXXX and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature.

@entity1 @entity5 @entity1221 @entity2033 @entity7730 @entity1349
UNASSIGNED: Atypical @entity5 (ATRT) is a @entity1221 with a dismal prognosis. There is no consensus on optimal treatment and different multimodal strategies are currently being used in an attempt to improve outcomes. To evaluate the impact of high-dose chemotherapy followed by autologous stem-cell rescue (HD48 SCR), radiotherapy (RT) at first line, @entity7730 ( @entity7730 ) and extent of surgical resection upon @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). An online database search identified prospective and retrospective studies focused on the treatment of @entity1 and adolescents with newly diagnosed ATRT. Clinical, therapeutic and outcome data were extracted and an individual pooled data analysis was conducted. Out of 389 publications, 12 manuscripts were included in our review. Data from 332 @entity1 were analysed. Median age at diagnosis was 37  months (range 1-231). @entity2033 -SCR, RT and @entity7730 had been administered to 28.6  % (58/203), 49.6  % (118/238) and 21  % (65/310) of the @entity1 , respectively. Gross total resection (GTR) had been achieved in 46.5  % (152/327) of the cases. In the multivariate analysis, hazard ratios (95  % Confidence Interval) for @entity2033 -SCR were: @entity1349 -HR  =  0.570 (0.357-0.910) p  =  0.019, and @entity1349 -HR  =  0.388 (0.214-0.704) p  =  0.002; and for RT: @entity1349 -HR  =  0.551 (0.351-0.866) p  =  0.01, and @entity1349 -HR  =  0.393 (0.216-0.712) p  =  0.002. @entity7730 and GTR were not significantly associated with improved @entity1349 or @entity1349 in the multivariate analysis. In our pooled data review, @entity2033 -SCR and RT at first line were associated with improved outcomes in @entity1 and adolescents with newly diagnosed ATRT.
