Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to XXXX and its severity.

@entity172 @entity1 @entity1356 @entity70561 @entity53517 @entity74 @entity461 @entity560
STUDY DESIGN: A case-control association study and a stratified study investigating the genetic etiology for @entity70561 . OBJECTIVE: To determine the association of restriction fragment length polymorphisms of @entity172 receptor, @entity560 receptor, @entity461 , and @entity53517 with susceptibility to @entity70561 and its severity. SUMMARY OF BACKGROUND DATA: Contribution of genetic backgrounds to the etiology for @entity70561 has been suggested by epidemiologic studies. METHODS: Genomic deoxyribonucleic acid samples obtained from 120 @entity1 (77 @entity1 and 43 @entity1 ) with @entity70561 and 306 control subjects without the disorder (166 @entity1 and 140 @entity1 ) were amplified by polymerase chain reaction, and polymorphism genotypes were determined by restriction endonuclease digestion. The distribution of genotypes was compared between @entity1 with the disorder and control subjects. In addition, the severity of ossification was determined by the number of ossified vertebrae in @entity1 with the disorder, and associations of the severity with age, gender, and genotypes were examined. RESULTS: @entity172 receptor (P = 0.007) and @entity1356 (P = 0.001) polymorphisms exhibited different distributions between @entity1 with @entity70561 and control subjects in @entity1 , but not in @entity1 . In @entity1 with the disorder, the severity of ossification was negatively correlated with age in @entity1 (P = 0.013), but not in @entity1 . @entity172 receptor polymorphism was associated with the severity only in @entity1 (P = 0.001). CONCLUSIONS: The contribution of genetic backgrounds is likely to be stronger in @entity1 than in @entity1 with @entity70561 . @entity172 receptor polymorphism was associated with both @entity74 , but @entity1356 polymorphism was associated only with its initiation in @entity1 .
