Comparative study of systemically and perineurally administered XXXX as an adjunct for supraclavicular brachial plexus block.

@entity1 @entity1340 @entity1337 @entity3481 @entity1341 @entity158
BACKGROUND AND AIMS: The study was designed to compare the effects of @entity1340 administered as an adjunct to @entity1341 in supraclavicular block to that of systemic administration, on postoperative @entity1337 and rescue analgesic requirement following upper limb surgeries. MATERIAL AND METHODS: A prospective, randomized, controlled, double-blind study was undertaken in @entity1 scheduled for upper limb surgeries under supraclavicular block. All the three group @entity1 received either of the following drugs mixtures: Group A - @entity1341 0.5%-18 ml + normal saline-7 ml for block and normal saline-10 ml intravenously. Group B - @entity1341 0.5%-18 ml + normal saline-7 ml mixture for block and @entity1340 (100 mg) diluted to 10 ml - intravenously. Group C - @entity1341 0.5%-18 ml + @entity1340 (100 mg) + normal saline-5 ml mixture and normal saline 10 ml intravenously. The @entity1 were observed for sensory, motor onset along with the duration of @entity3481 . @entity1 were monitored for sedation and hemodynamic parameters during intra-operative and postoperative period. @entity158 -free period and demand for rescue @entity1337 was noted in all the @entity1 . RESULTS: The study demonstrates that the mixture of @entity1340 and @entity1341 injected perineurally for supraclavicular brachial plexus block hastens the onset of sensory block, motor block and provides a longer duration of motor blockade and demand for rescue @entity1337 as compared to other two groups. CONCLUSIONS: In conclusion, the addition of @entity1340 to @entity1341 mixtures as an adjunct for supraclavicular brachial plexus block provide better postoperative @entity1337 for orthopedic upper extremity surgery in comparison to control or systemic @entity1340 group without any side effects.
