Chemopreventive effects of Coltect, a novel dietary supplement, alone and in combination with @entity2983 in XXXX -induced @entity694 in @entity35 .

@entity5 @entity18399 @entity6693 @entity6108 @entity8708 @entity2823 @entity3504 @entity18432 @entity13909 @entity14 @entity35 @entity46927 @entity694 @entity2983
OBJECTIVES: Coltect is a novel dietary supplement containing @entity6108 , green tea and @entity46927 . Previous reports have suggested that these agents can prevent @entity14 ( @entity14 ). The present study examined the chemopreventive effect of Coltect alone or combined with @entity2983 ( @entity3504 ) using the @entity8708 ( @entity18399 ) model in @entity35 . METHODS: The effect of Coltect was examined on HT-29 @entity14 cells by growth inhibition assay. Apoptosis was determined by @entity13909 - @entity2823 /PI staining. Male @entity35 were injected with DMH in vivo and treated with Coltect 150   mg/kg, @entity3504 50   mg/kg or their combination, by oral gavage. @entity18432 ( @entity18432 ) were identified by @entity6693 staining. RESULTS: HT-29 cells exhibited a dose-dependent response to Coltect. Part of the growth inhibition can be explained by the induction of mild-moderate apoptosis in @entity5 cells (28%) compared with the untreated cells (10%). In the in vivo model, the average number of @entity18432 was divided into small (1-3 crypts) or large (>= 4 crypts). The Coltect compound reduced the number of small and large @entity18432 similarly to @entity3504 (40% reduction). This reduction was amplified by combining the two agents (70% reduction). CONCLUSION: Coltect inhibits the growth of @entity694 cells, induces apoptosis and inhibits @entity18432 development. Furthermore, it augments the growth inhibitory effect of @entity3504 in vivo. This may be clinically important since this safe dietary supplement-drug combination can be administered as a chemopreventive regimen for the treatment of @entity14 .
