Effect of @entity1 natural killer and gammadelta T cells on the growth of @entity1 XXXX xenografts in @entity466 @entity19 .

@entity1 @entity5 @entity19 @entity320 @entity466
Natural killer (NK) cells were first identified for their ability to kill @entity5 cells of different origin in vitro. Similarly, gammadelta T lymphocytes display strong cytotoxic activity against various @entity5 cell lines. However, the ability of both the NK and gammadelta cells to mediate natural immune response against @entity1 @entity5 in vivo is still poorly defined. @entity466 ( @entity466 ) @entity19 have been successfully engrafted with @entity1 @entity5 . In this study, the antitumor effect of local as well as of systemic treatments based on NK cells or Vdelta1 or Vdelta2 gamma/delta T lymphocytes against @entity320 cells was investigated in vivo. The results show that all three of the populations were effective in preventing growth of autologous @entity1 @entity320 when both @entity5 and lymphoid cells were s.c. inoculated at the same site. However, when lymphoid cells were infused i.v., only NK cells and Vdelta1 gamma/delta T lymphocytes could either prevent or inhibit the s.c. growth of @entity320 . Accordingly, both NK cells and Vdelta1 gammadelta T lymphocytes could be detected at the s.c. @entity5 site. In contrast, Vdelta2 gammadelta T lymphocytes were only detectable in the spleen of the @entity466 @entity19 . Moreover, NK cells maintained their inhibitory effect on @entity5 growth even after discontinuation of the treatment. Indeed they were present at the @entity5 site for a longer period. These data support the possibility to exploit NK cells and Vdelta1 gammadelta T lymphocytes in @entity5 immunotherapy. Moreover, our study emphasizes the usefulness of @entity1 @entity5 / @entity466 @entity19 models for preclinical evaluation of immunotherapy protocols against @entity1 @entity5 .
