[Clinical or XXXX and thyroid autoantibody before 20 weeks pregnancy and risk of @entity600 : a systematic review].

@entity1 @entity1375 @entity3152 @entity600 @entity4207 @entity1374
OBJECTIVE: To evaluate the relationship between clinical or @entity1375 and positive thyroid autoantibody before 20 weeks pregnancy and risk of @entity600 . METHODS: Literature search was done in PubMed, EMBASE, Wanfang Medical Database, @entity4207 Database and China Biology Medicine disc databases from January 1st, 1980 to December 31th, 2013. The following search terms were used: @entity1375 , @entity1375 , hypothyroxinnism, thyroid antibody, @entity3152 , @entity600 , etc. (1) Criteria for inclusion:cohort studies and clinical studies were included; only articles that described at least 10 @entity1 were eligible;the exposure was clinical or @entity1375 and positive thyroid autoantihody, and outcome was @entity600 . (2) The excluded subjects were articles that described less than 10 @entity1 ; controls were pregnant @entity1 without eurothyrodisim. Meta-analysis was performed by RevMan 5. The relationship between clinical or @entity1375 and positive thyroid autoantibody and risk of @entity600 was evaluated by OR or RR. RESULTS: (1) Twenty cohort studies were enrolled. A total of 39 596 cases of @entity600 occurred among 498 418 pregnant @entity1 . The controls in these studies were pregnant @entity1 with eurothyrodisim. (2) @entity1375 in pregnancy: eight studies were included, reported data on 478 418 pregnant @entity1 (5 473 @entity1 with clinical @entity1375 and 472 945 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with clinical @entity1375 was higher than those eurothyroid pregnant @entity1 in control group (OR = 1.25, 95% CI:1.15-1.36, P < 0.01). (3) @entity1375 in pregnancy: ten studies were included, reported data on 277 531 pregnant @entity1 (5 257 @entity1 with @entity1375 and 272 274 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with @entity1375 was higher than those in control group by random effects analysis (OR = 1.25, 95% CI:1.14-1.36, P < 0.01). (4) Thyroid autoantibodys positive in pregnancy:eleven studies were included, reported data on 28 781 pregnant @entity1 (3 036 @entity1 with @entity1374 745 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with positive thyroid autoantibody was higher than those negative thyroid autoantibody in control group (OR = 1.47, 95% CI: 1.27- 1.70, P < 0.01). The funnel plots presented symmetrical graphics, indicating that there was no publication bias. CONCLUSION: Clinical or @entity1375 and positive thyroid autoantibody in pregnant @entity1 is risk factors of @entity600 .
