XXXX and metabolic risk factors: a study of young adults.

@entity1 @entity2289 @entity28 @entity301 @entity1144 @entity412 @entity1011 @entity583 @entity413 @entity165
OBJECTIVE: To assess the relative importance of the extent and regional distribution of fat for metabolic risk factors in young adults. DESIGN: Cross-sectional study of findings from a hospital-based case-control study. SUBJECTS: A total of 46 adult Danish Caucasian @entity1 (40 @entity1 and six @entity1 , aged 34-54 y). Of these, 22 had had non fatal @entity583 before 41 y of age and 24 were age- and gender-matched controls without @entity301 . MEASUREMENTS: Four measurements of fat: body mass index (BMI, kg/m(2)), body fat percentage measured using a dual energy X-ray absorptiometry (DEXA) scanner, waist/hip circumference ratio (WHR), and intra-abdominal adipose tissue area measured using computed tomography (CT) scanning, and eight metabolic risk factors: systolic and diastolic blood pressure, HbA(1c) percentage, fasting concentrations of capillary whole blood @entity413 , high-density lipoprotein (HDL) @entity165 , serum @entity412 , plasma @entity2289 ( @entity2289 ), and urinary albumin: @entity1011 excretion ratio. RESULTS: Of 46 @entity1 , 10 were @entity28 (BMI >30 kg/m(2)), 12 were @entity1144 (WHR >0.90 for @entity1 and >0.85 for @entity1 ), and 20 were @entity1144 (intra-abdominal adipose tissue area >135 cm(2)). @entity1 had a higher intra-abdominal adipose tissue area than @entity1 (P=0.0053, Mann-Whitney U-test). In multiple regression analyses of the four fat variables, only intra-abdominal adipose tissue area significantly predicted the levels of six metabolic risk factors: systolic blood pressure, diastolic blood pressure, fasting concentrations of capillary whole blood @entity413 , serum HDL @entity165 , serum @entity412 , and @entity2289 . The intra-abdominal adipose tissue area had a linear relation with the six metabolic risk factors. CONCLUSIONS: For young individuals, intra-abdominal fat is the important component of the body fat for six of the eight metabolic risk factors. Intra-abdominal fat might contribute to that most @entity1 with @entity583 at a young age are @entity1 .
