[Clinical epidemiological study of peri-conceptional multiple risk factors and XXXX ].

@entity1 @entity1800 @entity20802 @entity299
OBJECTIVE: To evaluate the associations between the occurrence of @entity299 ( @entity299 ) in @entity1 and exposures to peri-conceptional multiple nongenetic risk factors. METHODS: For this age-matched case-control study, standardized data were collected from 435 families of @entity1 with CHD and 574 families of non-malformed @entity1 . The questionnaires were conducted on multiple nongenetic risk factors including paternal characteristics and conditions, maternal therapeutic drug exposure, housing renovation, hair perming and dyeing and parental occupational exposure. RESULTS: The CHD @entity1 weighed less than control group (P < 0.01). However two groups had no significant differences in age, height, parental age or heart rate. Educational levels of parents had a negative correlation with CHD. Conotruncal defect and simple ventricular septum defect were the most common @entity299 . Therapeutic drug exposure, @entity1800 and occupational exposure all had a high level of correlation with @entity20802 (OR = 6.74, OR = 3.73, OR = 2.82 respectively). And ventricular septum defect was associated with therapeutic drug exposure, home decoration, hair perming and dyeing and parental exposure of work environment (OR = 2.77, OR = 1.76, OR = 1.89 respectively). CONCLUSION: Multiple nongenetic risk factors may contribute to the occurrence of CHD.
