The sinusoidal barrier in XXXX with @entity254 : a morphometric study.

@entity254 @entity409 @entity904 @entity1358 @entity35
Shunting of portal blood in the @entity35 leads to @entity409 and to an increase in arterial blood flow with microcirculatory disturbances. The aim of this study was to investigate the effects of these disturbances on the liver sinusoidal barrier (endothelial and @entity1358 ) using morphometric techniques. @entity35 with @entity254 ( @entity254 ) and sham operated pair-fed controls were studied 3 months after the shunt. Sinusoidal volume density in @entity254 increased but not significantly and the volume density (Vv) of total endothelial (EC) and @entity1358 ( @entity1358 ) increased by 104.54% compared to sham operated pair-fed @entity35 . The increase of EC Vv was not associated with an increase in surface density (Sv) suggesting a fall in the number of small fenestrations and an increase in cell thickness. This interpretation supports the morphological observations. The increase of @entity1358 Vv was mainly related to the increase in their subendothelial processes Vv and not to that of the cell body Vv. Lipids Vv and RER Sv expressed per sinusoidal cells remained unchanged suggesting that the balance between the 2 hypothetical functions of the @entity1358 , namely fibrogenesis and storage of @entity904 , was maintained. In conclusion, changes of EC and @entity1358 after @entity254 result mainly in thickening of the sinusoidal barrier. This increase may impair exchanges between the sinusoidal lumen and Disse space and contribute to functional abnormalities.
