Differences between first and subsequent fevers during prolonged XXXX .

@entity1 @entity801 @entity295 @entity281 @entity1398 @entity221
@entity221 during @entity1398 before engraftment was studied in 86 consecutively treated @entity1 undergoing allogeneic bone marrow transplantation. Eighty-four of the 86 @entity1 experienced 132 febrile episodes. Only 26% of the @entity1 had one fever which resolved with antibiotics. The rest required modification of antimicrobial therapy because of refractory fever (32%) or recurrent fevers (42%). The 121 fevers which occurred during @entity1398 were analyzed to determine differences between first and subsequent fevers (79 and 42 episodes, respectively). The frequency of @entity295 (23%) and defervescence (64%) did not differ between first and subsequent fevers. @entity281 ( @entity281 ) was identified in 75% of first fever but in only 28% of subsequent fevers (P = 0.000002). Of the @entity281 identified, oropharyngeal mucosal disease accounted for 68% during first fever but only 38% during subsequent fevers (P = 0.02). Although @entity295 in first fever was more frequently associated with @entity281 than @entity295 in subsequent fevers (61% versus 10%, P = 0.01), overall, @entity1 with @entity281 had a lower frequency of @entity295 than those without (17% versus 32%, P = 0.04). Gram-negative pathogens were uniformly @entity801 sensitive in @entity295 during first fever but were mostly @entity801 -resistant in @entity295 during subsequent fevers (P = 0.01).
