Quantitative T2, T2*, and T2' MR imaging in @entity1 with XXXX might detect microstructural changes and cortical @entity519 .

@entity1 @entity63 @entity16 @entity519 @entity194 @entity62
INTRODUCTION: Quantitative MRI with T2, T2*, and T2' mapping has been shown to non-invasively depict microstructural changes (T2) and oxygenation status (T2* and T2') that are invisible on conventional MRI. Therefore, we aimed to assess whether T2 and T2' quantification detects cerebral (micro-)structural damage and chronic @entity519 in lesions and in normal appearing white matter (WM) and @entity62 ( @entity62 ) of @entity1 with @entity63 ( @entity63 ). Measurements were complemented by the assessment of the cerebral blood flow (CBF) and the degree of @entity62 and WM @entity194 . METHODS: Eighteen @entity1 with @entity63 and 18 age-matched healthy controls were included. High-resolution, motion-corrected T2, T2*, and T2' mapping, CBF mapping (pulsed arterial spin labeling, PASL), and segmentation of @entity62 and WM were used to depict specific changes in both groups. All parameters were compared between @entity1 and healthy controls, using t testing. Values of p   <   0.05 were accepted as statistically significant. RESULTS: @entity1 showed significantly increased T2 in lesions (p   <   0.01) and in unaffected WM (p   =   0.045) as well as significantly increased T2* in lesions (p   =   0.003). A significant decrease of T2' was detected in @entity1 in unaffected WM (p   =   0.027), while no T2' changes were observed in @entity62 (p   =   0.13). Both unaffected WM and @entity62 were significantly decreased in volume in the @entity1 -group (p   <   0.01). No differences of PASL-based CBF could be shown. CONCLUSION: Non-invasive quantitative MRI with T2, T2*, and T2' mapping might be used to detect subtle structural and metabolic changes in @entity63 . Assessing the grade of @entity16 and @entity519 might be helpful to monitor disease progression and to perform risk assessment.
