Metabolic and therapeutic assessment of XXXX by two-hour and twenty-four-hour isocaloric meal tolerance tests.

@entity1 @entity6677 @entity28 @entity6 @entity2690 @entity1717 @entity98 @entity3190 @entity413
@entity28 @entity1 with @entity6677 (GDM) were given two different isocaloric meal challenge tests to assess @entity413 and @entity2690 responses. Forty-three pregnant @entity1 received a 400-kcal isocaloric breakfast meal tolerance test (mini-MTT). Twenty of the subjects were also given a 2000-kcal isocaloric diet with three meals and three snacks during a 24-h period (maxi- @entity98 ). This was the first study to utilize the physiologic challenge of mixed meals to compare @entity2690 and @entity413 responses of both @entity28 and lean normal pregnant @entity1 and @entity1 with GDM around the clock. Normal @entity28 pregnant @entity1 had higher integrated @entity413 and @entity2690 values around the 24-h clock (P less than 0.003 and less than 0.03, respectively) than lean pregnant @entity1 . @entity28 @entity1 with GDM also responded differently to the physiologic challenge of mixed meals. Some, but not all, @entity28 @entity6 subjects were markedly @entity1717 in contrast to lean @entity6 @entity1 who were relatively @entity2690 deficient. One normoglycemic massively @entity28 18-yr-old pregnant @entity1 was unexpectedly found to be severely @entity1717 . The two meal tolerance tests clearly defined a delay in the release of @entity2690 in @entity1 with GDM (lean and @entity28 ) and markedly different quantitative @entity2690 responses to identical meal challenges in @entity28 @entity6 subjects. @entity3190 was positively correlated with prepregnancy body mass index (kg/m2) and heavier @entity1 , but not with plasma @entity413 levels. These studies provide evidence that GDM is a heterogeneous syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)
