Association of @entity9554 XXXX gene polymorphism in @entity1569 cases with @entity101 .

@entity1 @entity101 @entity1569 @entity9554 @entity233 @entity5144 @entity272 @entity15379
BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity272 . Although, the molecular mechanism is not completely understood, @entity1569 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity9554 (eNOS @entity15379 ) gene polymorphism in @entity101 and/or non- @entity101 @entity5144 @entity1 (2) to investigate the possible relationship between the eNOS @entity15379 polymorphism and the risk of @entity101 among @entity5144 @entity1 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity233 @entity1 and Methods: Gene profiles of 75 @entity5144 @entity1 (21 @entity101 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5144 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity1 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity15379 single-nucleotide polymorphism (SNP) was determined in @entity5144 @entity1 when compared with normotensive non- @entity5144 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity101 @entity5144 @entity1 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5144 @entity1 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity15379 polymorphism and @entity101 among @entity5144 @entity1 in the Turkish population. The T allele frequency of eNOS @entity15379 SNP was different in @entity101 @entity5144 @entity1 , and the difference was statistically significant when compared with the normotensive @entity5144 @entity1 and healthy controls. These results need to be confirmed by large-scale studies.
