XXXX and immunophenotype of bone marrow plasma cells in monoclonal gammopathy of undetermined significance.

@entity1 @entity6460 @entity2940 @entity1075 @entity8058 @entity2225 @entity2282 @entity1582 @entity3053 @entity10317
AIMS: To determine whether a particular phenotype or antigen is preferentially related to @entity8058 ( @entity8058 ). METHODS: Bone marrow specimens from 56 @entity1 with @entity8058 were stained immunocytochemically (ABC peroxidase) for @entity3053 , @entity2940 , @entity6460 , @entity2282 , @entity1075 , @entity2225 , @entity10317 , and MB2. Specimens from @entity1 recently diagnosed with @entity1582 and reactive bone marrow samples were studied in parallel. RESULTS: @entity3053 was expressed on all plasma cells from all @entity8058 samples tested, while 36% were positive for @entity2940 , @entity6460 and MB2 were both expressed strongly; @entity2225 was moderately expressed, and staining for @entity2282 and @entity10317 was uncommon. For these five B cell antigens there was no clear difference between their expression in @entity8058 and in @entity1582 . A great difference was found for @entity1075 : in @entity8058 this antigen was expressed on 2-91% of plasma cells (mean 35%) and 77% @entity1 had > 10% positive plasma cells; in @entity1582 its expression was low and only 12% @entity1 had > 10% positive plasma cells. When these results were converted to numbers of @entity1075 positive plasma cells per 100 nucleated bone marrow cells, reactive bone marrow and @entity8058 specimens had a similar number of positive plasma cells. There was no correlation between expression of any of the antigens tested. CONCLUSIONS: Many of the so-called pre-B, B or activation antigens are present on plasma cells from @entity8058 specimens, and expression of @entity6460 , @entity2282 , @entity2225 , @entity10317 , MB2, and @entity3053 in @entity8058 was very similar to that in @entity1582 . @entity2940 was frequently expressed in @entity8058 . In this series @entity1075 was highly expressed in @entity8058 but not in @entity1582 . Plasma cells bearing this antigen could represent the non-neoplastic process and determination of its expression could be useful for the diagnosis of @entity8058 .
