Effects of @entity3044 and XXXX on the double potential interval after ablation of the cavotricuspid isthmus.

@entity3044 @entity1 @entity2643 @entity956
INTRODUCTION: A corridor of double potentials along the ablation line has been recognized to be an indicator of complete cavotricuspid isthmus block. @entity3044 is used to confirm cavotricuspid isthmus block, but the effects of @entity3044 on the double potential interval (DPI), either in the absence or presence of @entity2643 , are unknown. METHODS AND RESULTS: Thirty-two @entity1 with isthmus-dependent @entity956 underwent successful ablation of the cavotricuspid isthmus. The procedure was performed in the drug-free state in 23 @entity1 , and 2 to 7 days after discontinuation of chronic @entity2643 therapy in 9 @entity1 . Electrograms recorded along the ablation line before and during @entity3044 infusion were analyzed after isthmus block was achieved. Double potentials were recorded along the entire ablation line upon achievement of complete isthmus block in all @entity1 . The DPI in 9 @entity1 treated with @entity2643 was longer than in the other @entity1 (147 +/- 32 msec vs 119 +/- 19 msec, P < 0.001). The DPI increased as the pacing cycle length shortened in @entity1 treated with @entity2643 , but not in the other @entity1 . At all pacing cycle lengths, @entity3044 shortened the DPI to a greater extent in the @entity1 treated with @entity2643 than in the other @entity1 . CONCLUSION: @entity2643 results in rate-dependent prolongation of the DPI during coronary sinus pacing after ablation of the cavotricuspid isthmus. @entity3044 shortens the DPI despite the presence of complete isthmus block, and this effect is accentuated in the presence of @entity2643 .
