Depot long-acting XXXX analog ( @entity73208 ) is an effective treatment for @entity2012 .

@entity1 @entity5990 @entity2012 @entity73208 @entity977 @entity2390 @entity4841 @entity1943 @entity10
Octreotide ( @entity2390 ) is a synthetic analog of @entity1943 , an endogenous GH inhibitory peptide that has been used as an adjunct to surgery and radiotherapy in the treatment of @entity2012 . When given sc in divided daily doses, it lowers serum GH to less than 5 micrograms/L in approximately 50% of cases. Data suggest that continuous infusions of @entity1943 analogs may be more effective in lowering GH. We have evaluated @entity73208 , a new long-acting preparation of Sandostatin, in eight @entity1 with @entity2012 . After an initial pharmacokinetic study, @entity1 received a minimum of 10 im injections of @entity73208 (20, 30, or 40 mg) at 28- or 42-day intervals. Serum GH levels decreased from 10.7 +/- 2.8 micrograms/L (mean +/- SE) at baseline to a nadir of 2.6 +/- 0.4 micrograms/L after the tenth injection, and to less than 5 micrograms/L in every patient. Serum insulin-like growth factor-I decreased from 927 +/- 108 ng/mL at baseline to 472 +/- 59 ng/mL at the end of the sixth injection and returned to normal (< 500 ng/mL) in seven of the eight @entity1 . This was associated with significant improvements in @entity10 , @entity4841 , and sweating. There was no evidence of @entity2390 accumulation, and the drug was well tolerated. To date, no @entity5990 have occurred, and serial pituitary imaging has revealed no increase in the size of the initial @entity977 . In particular, two previously untreated @entity1 have shown complete regression of the initial microadenoma and have serum GH values of less than 2.5 micrograms/L. @entity73208 is an effective and well-tolerated treatment for @entity1 with @entity2012 . Undoubtedly the initial indication for @entity73208 will be in the @entity1 who is not cured after surgery and radiotherapy, but our experience suggests that it may be used as a primary treatment in some acromegalics.
