Skin capillary density and microvascular reactivity in @entity28 subjects with and without XXXX .

@entity1 @entity28 @entity450 @entity1144 @entity392 @entity272 @entity209 @entity65
@entity28 is associated with increased @entity65 and mortality. We hypothesized that microvascular function may be @entity28 with @entity209 (OB-MetSnd) compared to @entity28 subjects without MetSnd (OB) and @entity392 ( @entity392 ). In this cross-sectional study, we evaluated @entity272 ( @entity272 ) in OB-MetSnd (n=20, 12 @entity1 , BMI=36.5  1.1kg/m(2)), OB (n=25, 16 @entity1 , BMI=34.5  0.7kg/m(2)), and @entity392 (n=30, 22 @entity1 , BMI=22.8  0.3kg/m(2)) groups. @entity272 was evaluated by intravital video-microscopy at rest and after post-occlusive reactive @entity450 (PORH) and @entity450 ( @entity450 ). OB-MetSnd subjects exhibited significant differences in the values of MetSnd components and in leptin and HOMA-IR levels compared to OB and @entity392 individuals. There were no differences in @entity272 among groups in resting conditions. The OB-MetSnd group failed to show a significant increase in the number of recruited capillaries during PORH and @entity450 compared to the @entity272 evaluated at rest. A negative correlation of @entity272 with waist circumference, BMI, blood pressure, and HOMA-IR was observed after PORH and @entity450 . When @entity28 subjects were analyzed according to their HOMA-IR quartiles, a significant decrease in @entity272 was observed during POHR (P=0.02). Our findings showed that @entity28 subjects have structural and functional alterations in skin microcirculation that are proportional to the increase in the degree of @entity1144 . In addition, in OB-MetSnd subjects, the cutaneous capillaries at rest are already maximally recruited, indicating an absence of functional capillary reserve. This may be related to the insulin resistance observed in OB-MetSnd individuals.
