Sepsis is a major predictor of failure after ileal pouch-anal XXXX .

@entity1 @entity254 @entity292 @entity86 @entity204 @entity30
PURPOSE: This study aimed to determine the risk of ileal pouch-anal @entity254 failure and factors predictive of failure overall and in @entity1 with septic complications. METHODS: @entity1 were identified through a prospectively maintained @entity1 registry. All @entity1 registered in the Mount Sinai Hospital Inflammatory Bowel Disease database who had an ileal pouch-anal @entity254 for more than 12 months were included in the study. Pouch failure was defined as ileal pouch-anal @entity254 excision or permanent diversion. Cox proportional hazard models with @entity204 as a competing risk were created, modeling time to failure as the outcome of interest for all @entity1 and for the subgroup of @entity1 with septic complications. RESULTS: The study included 1,554 @entity1 . One hundred six @entity1 experienced an ileal pouch-anal @entity254 failure (6.8%), 49 (46.2%) of these failures were caused by septic complications. Independent predictors of failure included @entity30 (hazard ratio 7.5, 95% confidence interval [4.7, 12.0]) and @entity86 (hazard ratio 6.6, 95% confidence interval [4.4, 9.8]). In the subgroup of @entity1 with failure due to postoperative septic complications, independent predictors of failure were @entity30 (hazard ratio 2.7, 95% confidence interval [1.3, 5.7]) and presence of a pouch @entity292 (hazard ratio 2.6, 95% confidence interval [1.3, 5.2]). CONCLUSION: Septic complications are the most common cause of ileal pouch-anal @entity254 failure. Careful @entity1 selection and the prevention of septic complications may decrease the risk of this failure.
