Prognostic Impact of Central Nervous System @entity3 After Acquired Resistance to @entity470 -TKI: Poorer Prognosis Associated with XXXX -negative Status and @entity3 .

@entity1 @entity1313 @entity470 @entity1149 @entity149 @entity3 @entity669 @entity9513 @entity204
AIM: The aim of the present study was to investigate the prognostic @entity149 (CNS) after acquired resistance to @entity470 ( @entity470 )- @entity669 kinase inhibitor (TKI) in @entity470 -mutant @entity1149 ( @entity1149 ). @entity1 AND METHODS: We defined CNS-collapse as @entity204 due to uncontrolled and progressive CNS @entity3 . Post-progression survival (PPS) after initial TKI failure and @entity9513 status were retrospectively compared in 92 @entity1 with or without CNS collapse. RESULTS: The median PPS in 32 @entity1 with CNS-collapse (16.7 months) was significantly shorter than that of 60 without (26.8 months) (p=0.0002). @entity9513 was detected in four (12%) out of the 32 CNS-collapse @entity1 and in 26 (43%) out of 60 without (p=0.0026). Median PPS in 39 @entity1 with leptomeningeal @entity3 (LM) (11.4 months) was significantly shorter versus 53 without (26.8 months) (p=0.0006). The median PPS was 25.1 months in 40 @entity1 with brain @entity3 and 11.2 months in 52 without (p=0.0387). @entity9513 was detected in 4/5 resected @entity1313 (80%) and in 1/26 cerebrospinal fluid (CSF) samples (4%) (p=0.0008). CONCLUSION: CNS-collapse represented poorer prognosis, which was associated with @entity9513 -negative status and LM. Controlling CNS @entity3 , especially LM, is important to achieve longer survival.
