XXXX differentiate severe from benign @entity1315 .

@entity1 @entity131 @entity410 @entity1315 @entity302 @entity1893 @entity62
OBJECTIVE: @entity62 have been identified frequently in @entity1 with refractory mesial @entity1315 (rMTLE). However, the identification of potential water diffusion abnormalities in @entity1 with drug-responsive, benign MTLE (bMTLE) is still missing. The aim of this study was to identify markers of refractoriness in MTLE. METHODS: The study group included 48 @entity1 with bMTLE (mean age 42.8  +  13.5  years), 38 with rMTLE (mean age 41.7  +  14.1  years) and 54 healthy volunteers. Diffusion tensor imaging (DTI) was performed to measure @entity1893 ( @entity1893 ) and fractional anisotropy (FA) in a regions-of-interest analysis comprising hippocampi and temporal lobe gray and white matter regions. The presence of @entity131 ( @entity131 ) was assessed using automated magnetic resonance imaging (MRI) evaluation. For statistics we used chi-square test; two-tailed, two-sample t-test; and stratified linear regression. RESULTS: The significant demographic differences between the two @entity1 groups were sex (p  =  0.003), duration of @entity302 (p  =  0.003) and @entity410 (p  =  0.0001). In rMTLE, temporal white matter @entity1893 was higher and FA lower, as compared to bMTLE. The analysis of diagnostic accuracy (area under the receiver operator characteristic [ROC] curve [AUC]) showed that FA had an AUC for discriminating @entity1 affected from those unaffected by refractory MTLE of 74.0% (p  <  0.001), a value that was higher than that of temporal @entity1893 (64.0%), hippocampus volume (65.0%), and @entity131 (66.0%). SIGNIFICANCE: We performed DTI measurements in MTLE and found a significant reduction of FA along the white matter of the temporal lobes in rMTLE, suggesting it as a valuable measure of refractoriness in MTLE.
