Effect and mechanism of @entity905 on electrophysiology in vivo in a XXXX model of @entity308 .

@entity1 @entity26739 @entity308 @entity905 @entity301 @entity10277 @entity2224 @entity35 @entity583 @entity943
BACKGROUND: Major @entity308 is diagnosed in 18% of @entity1 following @entity583 ( @entity583 ), and the antidepressant @entity905 is shown to effectively decrease @entity308 and improve @entity301 prognosis. We observed the effect of @entity905 on cardiac electrophysiology in vivo in a @entity35 model of @entity583 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity35 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity583 ( @entity583 group), @entity308 ( @entity308 group), @entity583 (model group), and @entity583 treated with intragastric administration of 10 mg/kg @entity905 ( @entity905 group). @entity583 was induced by left anterior descending coronary artery ligation. @entity308 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity308 -like behaviors were observed in the @entity583 , @entity308 , and model groups, and chronic @entity905 administration could significantly improve those behaviors (P<0.05 vs model group). @entity905 significantly increased the @entity2224 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity26739 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity583 group, CMS group, and model group, which could be improved by @entity905 (30%  9%). But @entity905 showed no improvement on the @entity583 -induced loss of @entity10277 . CONCLUSION: The susceptibility to @entity943 was @entity308 and @entity583 @entity35 , and @entity905 may reduce the incidence of @entity943 in @entity583 @entity35 and thus improve the prognosis. This may be related in part to the upregulation of @entity26739 by @entity905 .
