Topological Reorganization of the Default Mode Network in XXXX .

@entity1 @entity308 @entity75 @entity148 @entity15131 @entity1744
UNASSIGNED: The aim of this study was to investigate the topological reorganization of the @entity75 ( @entity15131 ) in @entity1 with @entity1744 ( @entity1744 ) using resting-state functional magnetic resonance imaging (rs-fMRI). With approval by our ethics committee, rs-fMRI was prospectively performed in 31 @entity1744 @entity1 (25 male, 27        8  years) and 32 healthy controls (25 male, 29        9  years). The @entity15131 was determined by unbiased seed-based functional connectivity (FC) analysis and then parcellated into several subregions. FC across all pairs of @entity15131 subregions was computed to construct the @entity15131 architecture, for which topological properties were characterized by graph theoretical approaches. Pearson correlation was performed between abnormal @entity15131 inter-regional FC and network measures and clinical indices in @entity1744 @entity1 . Compared to healthy controls, @entity1744 @entity1 showed decreased @entity15131 inter-regional FC between the anterior cingulate cortex and precuneus, the medial orbital of the superior frontal gyrus (ORBsupmed) and precuneus, and the middle temporal gyrus and precuneus. @entity1744 @entity1 also showed @entity15131 (E glob). Inclusion of @entity148 and @entity308 as covariates abolished FC between ORBsupmed and precuneus and some E glob differences. The average @entity15131 FC was positively correlated with average E glob (r   =   0.47, P   =   0.008) and negatively correlated with symptom severity score (r   =   -0.37, P   =   0.04) in @entity1744 @entity1 . In conclusion, @entity1744 @entity1 showed topological reorganization of the @entity15131 to a non-optimized regularity configuration, which may partly be ascribed to high levels of @entity148 and @entity308 .
