[Observation time for drug administration and withdrawal in the treatment of XXXX with @entity6750 ].

@entity1 @entity1955 @entity6750
OBJECTIVE: To study the best observation time for drug administration and withdrawal in the treatment of @entity1 with transient @entity6750 ,seeking an objective basis for the safe drug withdrawal. METHODS: @entity1955 was prescribed for 1 144 @entity1 diagnosed with @entity6750 ( @entity6750 ) and according to the results @entity1955 was adjusted to a maintenance dosage. Examinations were performed periodically including physical and mental development, thyroid ultrasonography,and blood levels of T3, T4, TSH. For the @entity1 with a small maintenance dosage of @entity1955 (15.0 - 16.6 g/d) and all the examinations normal, @entity1955 was withdrawn at 2 - 3 years, and the @entity1 were followed up and reexamined after 1 month, 2 months, and 10 months, respectively. Permanent drug withdrawal was determined for @entity1 with all the examinations normal. Once abnormal TSH occurred, @entity1955 was prescribed again, and followed up continuously. RESULT: @entity1955 was withdrawn from 157 @entity1 . During the follow up, for 15 @entity1 (9.55%) @entity1955 were prescribed continuously, and for 142 @entity1 permanent drug withdrawal (confirmed with transient @entity6750 ) was determined. Abnormal TSH of various degrees was detected in 48 cases: 25.48 % (40/157),4.46 % (7/157), and 0.64 % (1/157) were detected at 1, 2 and 10 months after drug withdrawal, respectively. In 15 @entity1 @entity1955 was prescribed again for the remarkably high TSH, and the other 33 with mildly abnormal TSH finished the treatment since TSH normalized during follow-up. CONCLUSION: After 2 - 3 years of regular treatment, @entity1955 can be withdrawn from @entity1 with normal T3, T4, TSH, physical and mental development, and thyroid function. The best observation time for drug withdrawal should be 2 - 3 months. If T3, T4 and TSH levels are in the normal range, drug can be withdrawn safely. Once abnormal results were detected during follow-up, @entity1955 should be administrated continuously.
