Peak Weight and Height Velocity to Age 36 Months and Asthma Development: The Norwegian Mother and XXXX Cohort Study.

@entity1 @entity565 @entity1729 @entity1576
BACKGROUND: The immediate postnatal period is the period of the fastest growth in the entire life span and a critical period for lung development. Therefore, it is interesting to examine the association between growth during this period and childhood @entity1576 . METHODS: We examined the association of peak weight and height velocity to age 36 months with maternal report of current @entity565 at 36 months (n = 50,311), recurrent @entity1729 ( @entity1729 ) by 36 months (n = 47,905) and current @entity565 at 7 years (n = 24,827) in the Norwegian Mother and @entity1 Cohort Study. Peak weight and height velocity was calculated using the Reed1 model through multilevel mixed-effects linear regression. Multivariable log-binomial regression was used to calculate adjusted relative risks (adj.RR) and 95% confidence intervals (CI). We also conducted a sibling pair analysis using conditional logistic regression. RESULTS: Peak weight velocity was positively associated with current @entity565 at 36 months [adj.RR 1.22 (95%CI: 1.18, 1.26) per standard deviation (SD) increase], recurrent @entity1729 by 36 months [adj.RR 1.14 (1.10, 1.19) per SD increase] and current @entity565 at 7 years [adj.RR 1.13 (95%CI: 1.07, 1.19) per SD increase]. Peak height velocity was not associated with any of the @entity1576 . The positive association of peak weight velocity and @entity565 at 36 months remained in the sibling pair analysis. CONCLUSIONS: Higher peak weight velocity, achieved during the immediate postnatal period, increased the risk of @entity1576 . This might be explained by an influence on neonatal lung development, shared genetic/epigenetic mechanisms and/or environmental factors.
