@entity4187 , @entity5321 , and XXXX gene polymorphisms and susceptibility to @entity14 among Lebanese.

@entity1 @entity4187 @entity5 @entity1820 @entity14 @entity9164 @entity356 @entity5321
Mutations in the genes encoding enzymes involved in the metabolism of chemical carcinogens can significantly affect the risk of cell transformation and @entity5 development. The resident Lebanese population has experienced a sharp increase in @entity5 incidence within the last few years. The relationship between gene polymorphisms of metabolic enzymes and @entity1820 incidence was not previously investigated. The aim of this study was to investigate the relationship between @entity4187 , @entity5321 , and @entity9164 gene polymorphisms and @entity1820 incidence among Lebanese. Blood and/or paraffin-embedded biopsy samples were collected from @entity1 and healthy controls. The genotypes were determined by polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism. The results of the present case-control study show that the studied Lebanese population generally resembles Caucasian populations with respect to the considered polymorphisms. Further, the @entity9164 *0/*0 genotype is a significant risk factor for gastric (odds ratio   =   4.1; 95% confidence interval: 1.2-14.5) and @entity14 (odds ratio   =   3.8; 95% confidence interval: 1.7-8.5); on the other hand, @entity4187 *2A and @entity5321 *6 alone are not significantly associated with @entity1820 development, although @entity4187 *2A was more frequent among @entity1 . A remarkable and statistically significant 36.5-fold increase in the risk of @entity356 was observed among @entity1 with @entity4187 *2A/*2A combined with @entity9164 *0/*0. The investigation of genetic risk factors and susceptibility gene polymorphisms in Lebanese is helpful for better understanding of @entity1820 etiology.
