Antiepileptic effects of clobazam in XXXX .

@entity1 @entity410 @entity1568 @entity8925 @entity1245 @entity302 @entity6191
Many @entity1245 used as anticonvulsants have @entity1568 radicals in positions 1 and 4. @entity8925 has @entity1568 radicals in positions 1 and 5. We studied the antiepileptic effect of clobazam in 36 @entity1 with intractable @entity302 in childhood. Their ages were 1 year 1 month to 16 years 5 months (mean 8 years). The mean initial dose was 0.33 mg/kg of daily doses and increased up to 0.71 mg/kg. Nine cases ( @entity6191 2/2, secondary generalized @entity302 7/29) were completely free from @entity410 , and another 9 (secondary generalized @entity302 8/29, @entity302 /5) experienced a decrease of 50% or more in @entity410 frequency. @entity410 frequency did not change in 16, and increased in the other 2 (secondary generalized @entity302 2/29). The antiepileptic effects were observed on the first day to 10th day after clobazam treatment. There were recurrences of @entity410 in 4 out of 9 @entity1 with complete control of @entity410 , 1 month alter in 3 and 10 months later in one. Mean serum clobazam level of 7 improved cases was 73 ng/ml and that of 3 cases with no response was 94 ng/ml. Although mild clinical side effects such as drowsiness were observed transiently in 17 cases, no abnormality was found in laboratory investigations performed.
