Inability to acquire spatial information and deploy spatial search strategies in XXXX with lesions in dorsomedial striatum.

@entity66 @entity19 @entity75 @entity16 @entity149 @entity148 @entity4207 @entity2414
UNASSIGNED: Dorsal striatum has been shown to contribute to @entity4207 and memory, but the role of striatal subregions in this important aspect of cognitive functioning remains unclear. Moreover, the spatial-cognitive mechanisms that underlie the involvement of these regions in spatial navigation have scarcely been studied. We therefore compared @entity4207 and memory performance in @entity19 with lesions in dorsomedial (DMS) and dorsolateral striatum (DLS) using the hidden-platform version of the Morris water maze (MWM) task. Compared to sham-operated controls, animals with @entity16 were impaired during MWM acquisition training. These @entity19 displayed delayed @entity4207 , increased thigmotaxis, and increased search distance to the platform, in the absence of major @entity66 , working @entity2414 or changes in @entity148 or exploration. They failed to show a preference for the target quadrant during probe trials, which further indicates that @entity2414 was impaired in these animals. Search strategy analysis moreover demonstrated that DMS-lesioned @entity19 were unable to deploy cognitively advanced spatial search strategies. Conversely, MWM performance was barely affected in animals with lesions in DLS. In conclusion, our results indicate that DMS and DLS display differential functional involvement in @entity4207 and memory. Our results show that DMS, but not DLS, is crucial for the ability of @entity19 to acquire spatial information and their subsequent deployment of spatial search strategies. These data clearly identify DMS as a crucial brain structure for @entity4207 and memory, which could explain the occurrence of @entity149 in @entity75 that affect the dorsal striatum.
