Effects of physical exercise on cardiac dyssynchrony in @entity1 with XXXX .

@entity1 @entity3883 @entity1757 @entity1002
AIMS: The purpose of this study was to determine the effect of exercise on dyssynchrony in @entity1 with @entity1002 . METHODS AND RESULTS: Sixty @entity1 with a left ventricular ejection fraction (LVEF)  <= 35% were studied. @entity3883 ( @entity3883 ), intraventricular mechanical delay [Ts-(lateral-septal)], and left ventricular filling ratio were measured at rest and during exercise. Significant @entity3883 was defined as a difference between aortic and pulmonary pre-ejection times of >40 ms. @entity1757 was defined as a Ts-(lateral-septal) >65 ms. Forty-five @entity1 with no dyssynchrony at rest were analysed (age 62    14; LVEF 28    6%) and compared with a control group of 15 @entity1 with known dyssynchrony at rest. None of the 45 @entity1 without dyssynchrony at rest developed dyssynchrony during exercise based on @entity3883 and Ts-(lateral-septal). In the control group, @entity3883 decreased from 65    19 to 33    11 ms (P< 0.001) during exercise, whereas Ts-(lateral-septal) did not change. Persistence of dyssynchrony during exercise (decrease of @entity3883 <60%) was significantly associated with response to cardiac resynchronization therapy (CRT). Whereas all 10 responders had persistent dyssynchrony during exercise, 4 of the 5 non-responders (80%) had an exercise-induced decrease of @entity3883 >60% (P< 0.004). CONCLUSION: Exercise does not elicit mechanical dyssynchrony in @entity1 without dyssynchrony at rest. In @entity1 with significant dyssynchrony at rest, exercise-induced decrease of @entity3883 is common. Persistence of dyssynchrony during exercise might be a novel predictor of response to CRT.
