The effects of dried root aqueous extract of Salvia miltiorrhiza and its major ingredient in acceleration of orthodontic tooth movement in XXXX .

@entity35 @entity9248 @entity4613 @entity9249
OBJECTIVES: Salvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in @entity35 . MATERIALS AND METHODS: Male @entity35 (n= 150) were divided into five groups: model control group (0.5 ml/kg @entity4613 -buffered saline (PBS) injection), ESM group (0.75 g/kg/day of crude drugs) and Danshensu subgroups (250, 500, 750 mg/kg/day of body weight). All @entity35 were administered intramuscularly into the buccal vestibular mucosa of first molar of left maxillary. The indicators such as the moving distance of orthodontic tooth, nuclear factor kB ligand ( @entity9248 ) and @entity9249 ( @entity9249 ) expression and osteoclasts were tested. RESULTS: The expressions of @entity9248 and @entity9249 in the treatment groups were obviously enhanced compared with control group (P<0.05). The increase rate of @entity9249 expression was slower than that of @entity9248 . But, @entity9248 decreased conspicuously after no orthodontic pressure was applied, especially in the treatment groups (Danshengsu high dose group at day 30: 2.17 versus 3.47 of control, P<0.01). ESM groups promoted osteoclasts proliferation in the first 20 days. CONCLUSION: There is a relationship between @entity9248 / @entity9249 ratio and the number of osteoclasts. ESM might accelerate periodontal alteration of @entity35 orthodontic tooth via producing more osteoclasts.
