The pathophysiology of the chronic XXXX : a magnetic resonance imaging study.

@entity1 @entity9136 @entity8 @entity712 @entity101 @entity6 @entity470 @entity453
OBJECTIVE: To study the association of renal function with renal perfusion and renal parenchymal structure (T1 relaxation) in @entity1 with @entity712 ( @entity712 ). METHODS: After IRB approval, 40 @entity1 were enrolled according to @entity712 and renal function status [10 healthy volunteers   <   40  years; 10 healthy age-matched volunteers; 10 @entity712 @entity1 @entity470   >   60  ml/min/1.73  m(2); 10 @entity712 @entity1 @entity470   <   60  ml/min/1.73  m(2)] and assessed by MRI. To be eligible for enrolment all @entity712 @entity1 with @entity8 ( @entity8 ) needed to be diagnosed as having chronic @entity9136 based on current guidelines. @entity1 with primary @entity8 were excluded. RESULTS: Renal cortical perfusion correlated with @entity470 values (r   =   0.52;p   <   0.01) and was similar between @entity712 @entity1 with and without @entity8 (p   =   0.27). T1 relaxation correlated negatively with @entity470 values (r   =   -0.41;p   >   0.01) and was higher in @entity712 @entity1 compared to volunteers (1121        102  ms vs. 1054        65  ms;p   =   0.03). T1 relaxation was selectively prolonged in @entity712 @entity1 with @entity8 (1169  ms        100 vs. @entity712 without @entity8 1067  ms        79;p   =   0.047). In linear regression analyses @entity453 (p   =   0.01), @entity101 (p   =   0.04), and @entity6 (p   <   0.01) were associated with T1 relaxation. CONCLUSION: @entity8 in @entity712 is not primarily mediated by decreased renal perfusion. Instead, chronic reno- @entity8 , as indicated by prolonged T1 relaxation, appears to underly chronic @entity9136 . KEY POINTS:     The pathophysiology underlying chronic @entity9136 is not completely understood.     Chronic @entity9136 is independent of cardiac output or renal perfusion.     Renal T 1 relaxation appears to be prolonged in @entity712 with @entity8 .     Renal T 1 relaxation is associated with classic cardiovascular risk factors.     Association of renal T 1 relaxation with @entity8 should be validated further.
