The relationship between birth weight and maternal glycated haemoglobin (HbA1c) concentration in pregnancies complicated by @entity164 1 XXXX .

@entity4051 @entity1 @entity164 @entity6
AIM: To examine the relationships between maternal @entity4051 c concentration at different time points and birth weight in pregnancies complicated by pre-existing @entity164 1 @entity6 . METHODS: A comprehensive audit dataset was collected prospectively on all deliveries in Scotland to @entity1 with pre-existing @entity164 1 @entity6 occurring between 1 April 1998 and 31 March 1999. Data items included @entity4051 c concentrations prior to conception and in each of the three trimesters of pregnancy, and birth weight. Relationships between standardized birth weight and HbA1c concentrations at each of the four time points were examined using correlation analysis. RESULTS: Standardized birth weight (Z scores) could be calculated for 203 of 208 singleton liveborn @entity1 . HbA1c concentrations, standardized to correct for assay differences among hospitals, at different time points were available for between 134 (pre-pregnancy) and 192 (third trimester) cases. Standardized birth weight, relative to a reference population, showed a unimodal distribution, shifted to the right (mean, +1.57 sd). There was a significant negative correlation between pre-pregnancy @entity4051 c and birth weight (Spearman's R, -0.208; P = 0.016). There were no statistically significant correlations for other time points. CONCLUSIONS: Standardized birth weight scores of the @entity1 of @entity6 mothers are higher than those of a reference population. There is no simple relationship between maternal glycaemic status and birth weight, but there appears to be a paradoxical inverse relationship between pre-pregnancy glycaemic control and standardized birth weight.
