Transmural XXXX gradient: a new and robust quantitative index of left ventricular wall motion based on @entity296 imaging.

@entity1 @entity296 @entity583 @entity1166 @entity2845 @entity6475 @entity951 @entity453
BACKGROUND: Peak strain has been promising as an index of wall motion but it is sometimes susceptible to the image quality. OBJECTIVE: We investigated the feasibility of a novel index, transmural @entity296 gradient (TMSG), derived from @entity296 M-mode imaging (TDI-Q, Toshiba) for quantifying regional systolic wall motion. METHOD: We measured transmural @entity296 distribution at the left ventricular lateral, posterior, inferior, septal, anteroseptal and anterior walls in the basal and midventricular short-axis images using TDI-Q. Twenty normals (35    3 years) and 35 consecutive @entity1 (63    9 years) with @entity453 (CAD, 19 @entity1 with old @entity583 , 4 @entity1 with @entity583 , 12 @entity1 with @entity951 ) were studied. Peak strain, endocardial- and @entity6475 and TMSG ((peak strain, - epicardial strain)/distance between peak and @entity1166 ) were obtained. Coefficient of variation (CV) of each index was calculated. RESULTS: In control subjects, the best reproducibility of the variables was obtained for TMSG with the smallest CV (11.6%) (27.8%, 28.1%, and 35.5%, respectively for CV of peak strain, endocardial- and @entity6475 ). All segments in control subjects and normal segments in CAD @entity1 showed no significant difference in TMSG (15.1    1.8 vs. 15.1    1.6%/mm, P = ns). TMSG was the lowest for @entity2845 segments and highest for the normal segments (P < 0.001). CONCLUSION: TMSG was more robust than simple strain values to quantitatively assess wall motion. This could successfully identify subtle regional differences in wall function.
