Compression @entity254 Clips Versus a Hand-Sewn Technique for Intestinal XXXX in @entity1707 .

@entity1707 @entity254 @entity3885 @entity8566
BACKGROUND: Anastomotic dehiscence and leaks are major problems in gastrointestinal surgery and result in increased morbidity and mortality. The ideal device to create anastomoses should ensure good serosal apposition without requiring either transgression of the bowel wall or the presence of foreign material for an extended period of time. OBJECTIVES: The aim of this experimental study was to evaluate the safety and efficacy of a  new compression @entity254 clip (CAC) for jejunojejunostomies and ileocolostomies by comparing CAC anastomoses with @entity8566 ( @entity8566 ) anastomoses in @entity1707 in terms of healing, breaking strength and the time to create anastomoses. MATERIAL AND METHODS: The 11 @entity1707 in the study underwent side-to-side CAC and @entity8566 jejunojejunostomies and ileocolostomies, for a  total of 88 anastomoses. The @entity1707 were sacrificed on postoperative day 5 (5 @entity1707 ) or 7 (6  @entity1707 ). Macroscopic, histopathological and breaking-strength examinations were performed. The time to create the anastomoses was recorded. RESULTS: Neither group had anastomotic complications such as @entity3885 . Macroscopic examination showed no statistically significant differences between the groups. In the CAC group, the healing process was characterized by a  lesser inflammatory reaction (p  <  0.05) and very thin scar tissue at the anastomotic line (less collagen deposition and better epithelial regeneration), while the @entity8566 group had a  much thicker anastomotic line. The breaking strength was significantly greater in the CAC group compared with the @entity8566 group (p  <  0.05). The @entity254 time was shorter in the CAC group than in the @entity8566 group (p  <  0.01). CONCLUSIONS: @entity254 using a  CAC appears to be safe and less time-consuming than @entity8566 ; it was also characterized by a  good healing process with little inflammatory reaction and a  high breaking strength compared with @entity8566  @entity254 .
