The prevalence of XXXX in @entity1 across the United States with @entity72 from families with multiple affected members.

@entity1 @entity294 @entity2438 @entity344 @entity72 @entity1142
OBJECTIVE: : To perform a large registry-based study to determine the relative prevalence of gastrointestinal (GI) problems in @entity1 with an @entity72 ( @entity72 ) from families with multiple affected members compared with their unaffected sibling(s). METHODS: : In-home structured retrospective medical history interviews by parent recall were conducted by a pediatric neurologist. Our analysis sample included information about GI health of 589 subjects with idiopathic, familial @entity72 and 163 of their unaffected sibling controls registered with @entity2438 Genetic Resource Exchange. Individuals with @entity72 were subgrouped into 3 @entity2438 severity groups (Full @entity2438 , Almost @entity2438 , and Spectrum) based on their @entity2438 Diagnostic Interview-Revised and @entity2438 Diagnostic Observation Scale scores. RESULTS: : Parents reported significantly more @entity344 in @entity1 with @entity72 (249/589; 42%) compared with their unaffected siblings (20/163; 12%) (p < .001). The 2 most common Gl problems in @entity1 with @entity72 were @entity1142 (116/589; 20%) and chronic @entity294 (111/589; 19%). Conditional logistic regression analysis showed that having Full @entity2438 (adjusted odds ratio [AOR] = 14.28, 95% confidence interval [CI]: 6.22-32.77) or Almost @entity2438 (AOR = 5.16, 95% CI 2.02-13.21) was most highly associated with experiencing @entity344 . Increased @entity2438 symptom severity was associated with higher odds of @entity344 (AOR for trend = 2.63, 95% CI: 1.56-4.45). CONCLUSIONS: : Parents report significantly more @entity344 in @entity1 with familial @entity72 , especially those with Full @entity2438 , than in their unaffected @entity1 . Increased @entity2438 symptom severity is associated with increased odds of having @entity344 .
