Adverse outcomes of XXXX in school-age survivors.

@entity1 @entity410 @entity4008 @entity1276 @entity146 @entity2167 @entity508 @entity1650 @entity16 @entity693 @entity1939 @entity51 @entity393
OBJECTIVE: To determine the outcomes of @entity4008 in school-age survivors. DESIGN: Prospective cohort study. SETTING: Teaching pediatric hospital. @entity1 : During 1983 through 1986, 158 @entity693 survivors, ages 3 months to 14 years, treated at a single center were enrolled. Between 1991 and 1993, 130 @entity1 , 82% of the original cohort, were evaluated at a mean age of 8.4 years and a mean of 6.7 years after their @entity693 . OUTCOME MEASURES: Blinded neurologic, neuropsychologic, audiologic, behavior, and socio-demographic assessments were compared with those from grade- and sex-matched control @entity1 . Multivariate analyses adjusted for age at testing and socio-demographic variables. RESULTS: There was a systematic increase in risk of abnormality or poorer functioning for @entity1 with @entity693 , compared with control @entity1 , across all categories tested, which was significant for fine motor function, Intelligence quotient (IQ) scores, and tests of school behavior, neuropsychologic function, and auditory figure-ground differentiation. Eleven @entity1 who had experienced @entity693 (8.5%) had @entity51 (IQ < 70, @entity410 , @entity1276 , @entity508 , @entity1939 , or severe to profound @entity393 ); a further 24 (18.5%) cases and 14 (10.8%) control @entity1 had minor deficits (IQ 70 to 80, inability to read, mild to moderate @entity393 , @entity1650 , or school behavior problems). Overall, @entity1 who had @entity693 were at greater risk (26.9%) for disability. @entity1 with @entity16 had more adverse outcomes than those with uncomplicated @entity693 and control @entity1 (39% vs 18% vs 11%, respectively). CONCLUSIONS: One in four school-age @entity693 survivors has either serious and disabling sequelae or a functionally important @entity146 , @entity2167 adversely affecting academic performance. As a group, survivors function less well than their classroom peers, and risk is greatest for, but not confined to, those who had @entity16 . All survivors require careful follow-up, at least until school age.
