Non-instrumented extradural lumbar spine surgery under low-dose XXXX : a comparative risk analysis study.

@entity1 @entity190 @entity117 @entity1410 @entity86 @entity453 @entity7943 @entity65 @entity890
PURPOSE: @entity453 ( @entity453 ) affects over one-third of adults and is the leading cause of overall mortality and morbidity. @entity117 ( @entity7943 ) is widely used in the prevention of @entity453 . As the population continues to mature, the number of @entity1 presenting for spinal surgery that are under @entity7943 treatment is rising. Studies investigating the outcome of lumbar spine surgeries without discontinuation of @entity7943 therapy are lacking. The purpose of this study is to evaluate the peri- and @entity86 and @entity65 rates of @entity1 undergoing non-instrumented, extradural, lumbar spine surgery with or without discontinuation of low-dose @entity7943 . METHODS: We retrospectively compared the intra- and postoperative @entity190 , morbidity, mortality, blood transfusion requirements and hematologic findings in the @entity7943 group (40 @entity1 ) and the control group (62 @entity1 ). The diagnosis in all @entity1 was either @entity890 . RESULTS: Intraoperative @entity190 was 221  ml in the @entity7943 group and 140.16  ml in the control group, showing no statistical difference (p  =  0.08). @entity86 was 146.58 and 167.97  ml in the @entity7943 and control groups, respectively, also without statistical difference (p  =  0.76). In the @entity7943 group one @entity1 developed a @entity86 needing revision surgery, while in the control group no postoperative epidural @entity1410 were seen (p  =  0.40). In addition, blood transfusion requirements, hematologic findings, morbidity and mortality showed no significant difference. CONCLUSION: The continuation of @entity7943 treatment in @entity1 undergoing non-instrumented extradural lumbar spinal surgery seems to be safe and its perioperative continuation might therefore be recommended. Further studies confirming these results are needed.
