Persistence of increased XXXX ( @entity14700 ) level in tears of @entity1 wearing contact lenses: a long-term follow-up study.

@entity1 @entity5902 @entity2194 @entity14700
BACKGROUND: @entity14700 ( @entity14700 ) is a potent eosinophil chemotactic and activating peptide that may be implicated in the pathogenesis of @entity2194 and has been associated with the wearing of contact lenses (CL) in @entity1 with @entity5902 ( @entity5902 ). The purpose of this study was to study @entity14700 expression in the tears of long-term CL wearers. @entity1 AND METHODS: Tears were collected with glass capillaries from 15 @entity1 (2 male, 13 female) with various degree of @entity5902 at 2-year intervals. @entity5902 severity was graded from 0 to 4 with reference to standard slit-lamp photographs of the superior tarsal conjunctiva. The @entity14700 level in the tears was measured by an ELISA, using mouse anti-human eotaxin monoclonal antibodies. RESULTS: The mean age was 32.5    13.3 years (range: 17 - 69 years). The mean interval between the tear collections was 30    4.8 months. The mean concentration of eotaxin was 2150    477 pg/mL and 2486    810 pg/mL for the first and second series, respectively. The difference was not statistically significant (paired Wilcoxon/Kruskal-Wallis, p = 0.803). The mean score of papilla grade was 1.26    0.18 for the first sample and 1.40    0.19 two years later. There was no significant difference of grading between the two time periods (paired Wilcoxon/Kruskal-Wallis, p = 0.751). CONCLUSIONS: the @entity14700 level remains up-regulated over a long time period in @entity1 wearing CL, most of them with chronic @entity5902 . Eotaxin may play a role in the pathogenesis of contact lens intolerance.
