[Role of sperm antibodies and cellular XXXX to sperm in the pathogenesis of male infertility].

@entity1 @entity19474 @entity792 @entity3893
OBJECTIVE: To test the hypothesis of relationship between sperm pathology and elevated humoral and/or cell-mediated antisperm @entity792 in male partners from infertile couples. DESIGN: Analytic study. SETTING: Department of Immunobiology, Institute for the Care of Mother and @entity1 , Prague. METHODS: Sperm samples were evaluated according to WHO rules. Sperm-bound antisperm autoantibodies (ASA) were determined by SpermMar Test (FertiPro N. V., Sint-Martens-Latem, Belgium). For evaluation of cell-mediated antisperm @entity792 (CMAA) the authors used their own modification of migration-inhibition test (Dimitrov et al., J. Immunol. Methods 154: 147, 1992). RESULTS: The pool of @entity1 was divided into groups according to the result of sperm examination: normozoospermia (740 @entity1 ), @entity19474 (244), teratozoospermia (191), oligoasthenozoospermia levis (61), oligoasthenozoospermia gravis (29), oligoteratozoospermia (82), and @entity3893 (54). Subgroup of fertile @entity1 (32) consisted of normozoospermic @entity1 --fathers of @entity1 younger than 3 years. Percentage of sperm-bound ASA-positive samples was significantly higher in @entity19474 in comparison with normozoospermia in both IgA (20.8% versus 10.6%) and IgG classes (13.8% vs 6.8%). Positivity of CMAA was significantly more frequent in group of asthenozoospermic (52%) than in normozoospermic (28.5%) and fertile (12.5%) men. CONCLUSION: Antisperm @entity792 , namely its cell-mediated form, appears to play a significant role in impairment of spermiogenesis. Sperm-bound autoantibodies were found more frequently in @entity19474 , but also in some @entity1 with normozoospermia they may impair fertility.
