Unexpected role of inflammatory signaling in hematopoietic stem cell development: its role beyond XXXX .

@entity281 @entity32
PURPOSE OF REVIEW: Inflammatory signaling under pathological conditions like @entity281 and @entity32 has been extensively studied. Whether inflammatory signaling plays a role in physiology and development remains elusive. The review summarizes recent advances in inflammatory signaling with particular focus on how distinct inflammatory signaling regulates hematopoietic stem cell (HSC) development. Understanding the underlying mechanism of inflammatory signaling on HSC development may help to generate and/or expand a large number of functional HSCs for clinical application. RECENT FINDINGS: Like the hematopoietic progenitors, HSCs can be the first responders to @entity281 . An unexpected observation is that genes involved in innate immunity and inflammatory signaling are enriched in emerging HSCs and their niche during embryogenesis. Thus, inflammatory signaling may also play a role in HSC development in the absence of @entity281 and @entity32 . SUMMARY: Inflammatory signaling is not only an important regulator of HSCs in response to @entity281 , but also plays a previously unrecognized role in HSC development in the absence of @entity281 and @entity32 . The baseline inflammatory signaling can be activated to promote HSC development in cell autonomous and noncell autonomous manners. However, direct response of HSCs to inflammatory stimuli is not always advantageous and excessive chronic signaling can have negative effects on HSC regulation and function.
