Stimulation by XXXX of @entity934 release and synthesis in cortical slices from @entity35 brain.

@entity1760 @entity1022 @entity1617 @entity2607 @entity3897 @entity460 @entity35 @entity4338 @entity934
1. Cortical slices from @entity35 brain were incubated in media containing the irreversible cholinesterase inhibitor soman and a high KCl concentration, and the release and synthesis of @entity934 ( @entity1617 ) were determined.2. @entity3897 enhanced the release and synthesis of @entity1617 .3. @entity1022 , a substance which blocks nervous conduction, did not influence the release and synthesis of @entity1617 , in the absence or in the presence of @entity3897 . Therefore the nerve endings are probably the site at which @entity3897 acts when stimulating the release and synthesis of @entity1617 .4. Pretreatment of the slices with botulinum type A toxin partially blocked the release and synthesis of @entity1617 and reduced the extra amounts of @entity1617 released and synthesized under the influence of @entity3897 .5. Lowering the @entity460 or raising the @entity1760 concentration in the incubation medium reduced the release and synthesis of @entity1617 and their enhancement by @entity3897 .6. @entity2607 decreased the total extractable @entity1617 content of the slices during incubation in a 25 mM @entity4338 containing medium. This decrease was nearly prevented when the release and synthesis of @entity1617 were inhibited by omission of the @entity460 ions from the medium, but was enhanced by @entity3897 .7. The observations made with pretreatment by botulinum type A toxin, with changes in the @entity460 and @entity1760 concentration as well as with @entity2607 , all support the theory that it is primarily the release of @entity1617 which is enhanced by @entity3897 and that its stimulating action on the synthesis results from the increased release.
