[Behavioral effects of m-CPP and XXXX during ovarian cycle in female @entity35 ].

@entity172 @entity73182 @entity308 @entity146 @entity148 @entity750 @entity35
A comparative analysis of the influence of chronic administration of the 5-HT2B/2C receptor agonist, m-CPP (0.5 mg/kg, i.p.), and the 5-HT2A/2C receptor antagonist, @entity73182 (0.1 mg/kg, i.p.) for 14 days on the @entity148 and @entity308 -like behavior in the adult female @entity35 was performed. The @entity308 in @entity35 was modeled using the Porsolt test. The @entity148 level was assessed in the elevated plus maze test. It was established that @entity73182 induced antidepressive and anxiolytic effects in females during estrous and proestrous periods. The m-CPP administration also resulted in antidepressive effect in both estrous and proestrous periods. A clear modulation was observed in the @entity146 as dependent on the ovarian cycle phases in @entity35 treated with m-CPP: the anxiolytic effect was manifested at an increased level of @entity172 , while anxiogenic effect was manifested at a reduced level of @entity172 . It is suggested that @entity750 subtype receptors are involved to different extent in the mechanisms of @entity146 depending on the alterations of hormonal balance during the ovarian cycle. The data obtained are indicative of a close interaction between the ovarian hormonal and serotonergic systems of the brain in the mechanisms of @entity148 and @entity308 .
