One-year Outcome of Bilateral Subthalamic Stimulation in XXXX : An Eastern Experience.

@entity1 @entity3034 @entity409 @entity910 @entity191 @entity400
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely accepted as a treatment for advanced @entity191 ( @entity191 ). However, published studies were conducted mainly in Western centers and recruited small numbers of @entity1 . This study presents 1-year outcomes in Taiwanese @entity1 with @entity191 . METHODS: Sixty-two consecutive @entity1 underwent STN-DBS surgery during a 7-year period. Their median drug-off Hoehn and Yahr stage was 3 and mean illness history was 8 years. Clinical outcomes were evaluated by the change in drug-off/DBS-on Unified @entity191 Rating Scale (UPDRS) scores relative to presurgical drug-off baseline and change in daily @entity3034 -equivalent dose (LED). RESULTS: After 1 year of DBS therapy, @entity1 showed significant improvements with a clinically high effect size in cardinal signs, particularly in @entity400 (63%). Posture instability was also improved, whereas @entity409 was hardly corrected. The LED need was significantly reduced, therefore preoperative drug-induced complications were prominently (51%) ameliorated after surgery and drug-induced @entity910 was remarkably (63%) diminished. No serious adverse effects were encountered after surgery. Overall, motor functions declined by 15% within 1 year in drug-off state. CONCLUSIONS: Bilateral STN-DBS therapy provided effective and sustained benefits to Eastern @entity1 with @entity191 over a 1-year period.
