Association of XXXX gene polymorphisms with age-related macular egeneration susceptibility.

@entity1 @entity9346 @entity1129 @entity4050 @entity50363 @entity1020
OBJECTIVE: This study was aimed to confirm whether @entity50363 and @entity9346 polymorphisms of @entity4050 ( @entity4050 ) were risk factors for @entity1020 ( @entity1020 ). METHOD: 109 @entity1020 @entity1 and 165 @entity1020 -free controls were enrolled in the study. The @entity50363 and @entity9346 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by the X(2) test to assess the relationship of @entity50363 and @entity9346 polymorphisms with @entity1020 risk. Analysis of haplotype and stratification by age and smoking status was conducted as well. RESULTS: AA genotype and A allele of @entity50363 polymorphism was significantly associated with increased risk for @entity1020 (OR = 3.75, 95% CI = 1.70-8.30; OR = 1.64, 95% CI = 1.14-2.36). For @entity9346 polymorphism, CT genotype showed strong effects on the occurrence of @entity1020 (OR = 2.10, 95% CI = 1.04-4.27). Moreover, C allele was also a risk factor for @entity1020 (OR = 1.95, 95% CI = 1.02-3.72). The haplotypes analysis suggested that the risk for @entity1129 haplotype carriers was high, compared with GT haplotype (OR = 3.91, 95% CI = 2.58-5.94). In addition, we found that smoking status could affect the genotype distribution of @entity9346 polymorphism (P < 0.05). CONCLUSIONS: Our results revealed that @entity4050 polymorphisms @entity50363 and @entity9346 might be associated with the susceptibility to @entity1020 in Chinese population.
