Association between inflammatory airway disease of XXXX and exposure to respiratory viruses: a case control study.

@entity1 @entity32 @entity45884 @entity1641 @entity565 @entity2490 @entity683 @entity1800 @entity1576 @entity1729 @entity13445 @entity13444
BACKGROUND: @entity32 ( @entity32 ) in @entity1641 , similar to @entity565 in @entity1 , is a common cause of chronic poor respiratory health and exercise intolerance due to airway @entity32 and exaggerated airway constrictive responses. @entity1 rhinovirus is an important trigger for the development of @entity565 ; a similar role for viral @entity1576 in @entity1641 @entity32 has not been established yet. METHODS: In a case-control study, @entity1641 with @entity32 (n   =   24) were compared to control animals from comparable stabling environments (n   =   14). @entity1641 were classified using pulmonary function testing and bronchoalveolar lavage. PCR for @entity1641 @entity2490 virus A and B ( @entity45884 , ERBV), @entity683 virus (EIV), and herpesviruses 2, 4, and 5 ( @entity13444 , @entity13445 , @entity13444 ) was performed on nasal swab, buffy coat from whole blood, and cells from BAL fluid (BALF), and serology were performed. Categorical variables were compared between @entity32 and control using Fisher's exact test; continuous variables were compared with an independent t-test. For all analyses, a value of P <0.05 was considered significant. RESULTS: There was a significant association between diagnosis of @entity32 and history of cough (P   =   0.001) and exercise intolerance (P   =   0.003) but not between nasal discharge and @entity32 . @entity1641 with @entity32 were significantly more likely to have a positive titer to @entity45884 (68  %) vs. control @entity1641 (32  %). @entity1641 with @entity32 had higher log-transformed titers to @entity45884 than did controls (2.28        0.18 v.1.50        0.25, P   =   0.038). There was a significant association between nasal shedding (positive PCR) of @entity13444 and diagnosis of @entity32 (P   =   0.002). CONCLUSIONS: @entity32 remains a persistent problem in the @entity1641 population and has strong similarities to the @entity1 disease, @entity565 , for which @entity1800 is an important trigger. The association between viral @entity1729 and development or exacerbation of @entity32 in this study suggests that @entity1800 may contribute to @entity32 susceptibility; there is, therefore, merit in further investigation into the relationship between respiratory virus exposure and development of @entity32 .
