An @entity2931 -producing XXXX responsible for gynaecomastia.

@entity1 @entity251 @entity2931 @entity5 @entity53 @entity3566 @entity1062 @entity4797 @entity10548
In feminising @entity5 , @entity2931 can be either secreted by the @entity5 itself or produced by normal Leydig cells in response to paracrine and/or endocrine stimulation by @entity3566 . @entity5 patterns include: plasma @entity53 levels > 300 pmol/l on day 3 following an @entity3566 injection, reduced plasma @entity251 , and normal plasma @entity3566 and gonadotrophin levels. Except for elevated plasma @entity53 levels, opposite results are observed in @entity4797 . We report a case of @entity2931 -secreting @entity4797 mimicking a @entity5 . A 24-year-old Caucasian @entity1 had complained of gynaecomastia for 6 months before admission. Hormonal pattern was typical of @entity5 . A 1.4 cm @entity5 was found in the left @entity1062 and confirmed on sonography. Considering the likely diagnosis of @entity5 , the @entity1 was treated by tumourectomy. Surprisingly, pathological examination revealed a pure @entity4797 . Perifusion experiments showed that the @entity5 was able to secrete significant amounts of @entity53 . In addition, @entity3566 induced a two-fold increase in @entity53 production from perifused @entity5 explants. Immunohistochemistry revealed that the @entity5 was composed of nests of @entity4797 cells intermingled with lymphoid infiltrates. @entity5 cells also expressed aromatase, the @entity3566 / @entity10548 and the Leydig cell marker relaxin-like factor, but were betahCG-negative. These results demonstrate that a pure @entity4797 of the @entity1062 is able to synthesise and secrete @entity2931 . They also illustrate that the body of proof favouring the diagnosis of feminising @entity5 of the @entity1062 is not rigorously specific.
