Prognostic impact of standard laboratory values on outcome in XXXX with sudden @entity1274 .

@entity1 @entity393 @entity1274 @entity4365
BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after @entity1274 (SSNHL). METHODS: Using a retrospective review, 173 @entity1 were included presenting between 2006 and 2009 with unilateral SSNHL, >= 30  dB bone conduction in three succeeding frequencies between 0.125 to 8  kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics    <=   4  weeks. Hearing gain of <10  dB versus >= 10  dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. RESULTS: The initial @entity393 was 50.6        27.2  dB. The absolute @entity393 was 15.6        20.1  dB. Eighty-one @entity1 (47%) had a final @entity393 of >= 10  dB. @entity4365 (p <0.0001); start of inpatient treatment <4  days after onset (p   =   0.018); first SSNHL (versus recurrent SSNHL, p   =   0.001); initial @entity393   >=    60  dB (p   <   0.0001); an initial quick value lower than the reference values (p   =   0.040); and a pretherapeutic hyperfibrinogenemia (p   =   0.007) were significantly correlated to better outcome (>= 10  dB absolute @entity393 ). Multivariate analysis revealed that first SSNHL (p   =   0.004), start of treatment <4  days after onset (p   =   0.015), initial @entity393   >=    60  dB (p   =   0.001), and hyperfibrinogenemia (p   =   0.032) were independent prognostic factors for better hearing recovery. CONCLUSION: Better @entity393 in @entity1 with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors.
