Arterial remodeling of the common carotid artery after aortic valve replacement in @entity1 with XXXX .

@entity1 @entity854 @entity472 @entity121
BACKGROUND AND PURPOSE: @entity472 , causing @entity854 , disturbs the normal hemodynamics in the common carotid arteries. The aim of the present study was to investigate the remodeling process of the common carotid arteries after surgical correction of @entity472 . METHODS: Eleven subjects with @entity472 were studied before and 1 and 6 months after aortic valve replacement. Arterial diameter, @entity121 ( @entity121 ), and flow velocity were measured by echo-Doppler examination. Shear stress, blood flow, and pulsatility index were calculated. Blood viscosity and hematocrit were measured by standard methods. A control group was also enrolled. RESULTS: Before surgery, compared with controls, @entity1 had lower systolic peak velocity but higher mean and end-diastolic velocity. Arterial diameter, @entity121 , and blood flow were comparable in the 2 groups. Blood viscosity, hematocrit, wall shear stress, and pulsatility index were markedly lower in @entity1 . After surgery, @entity121 was reduced (0.741+/-0.152 versus 0.627+/-0.108 mm before and 6 months after surgery, respectively; P<0.0001), and hematocrit and blood viscosity increased, leading to increased wall shear stress (mean wall shear stress, 7.83+/-1.97 versus 9.65+/-3.12 dyne/cm(2) before and 6 months after surgery, respectively; P<0.02). CONCLUSIONS: The present results demonstrate that aortic valve replacement, in subjects with @entity472 , leads to reduction of the common carotid artery @entity121 . Wall shear stress is increased after the intervention and probably mediates the remodeling process.
