Prognostic significance of proteolytic enzymes in XXXX @entity1313 .

@entity1 @entity2289 @entity320 @entity1313 @entity5 @entity39 @entity4 @entity11 @entity1653 @entity816 @entity3 @entity463 @entity2290
Proteases and their inhibitors have been shown to play roles in @entity5 invasion and @entity3 in a number of experimental models. Recently, relative increases in the amounts of urokinase type plasminogen activator ( @entity2290 ) and plasminogen activator inhibitor-1 ( @entity2289 ) in @entity5 samples have been correlated with poorer, pathological grade, shorter disease-free interval, and shorter survival. To date, all studies investigating the prognostic significance of proteases and their inhibitors have been limited to extracranial @entity5 . In this article, we review the literature and present our data on the prognostic significance of proteases in @entity1 @entity1313 . High levels of @entity2290 were seen in @entity11 and @entity3 (n = 82), whereas normal levels of @entity2290 were found in low-grade @entity11 . Analysis with magnetic resonance imaging (MRI) demonstrated a significant correlation between high levels of @entity2290 and @entity39 and @entity4 (n = 50; P < 0.05). Similarly, @entity1 with high levels of @entity2290 had shorter survival than did @entity1 with low levels of @entity2290 . Tissue-type plasminogen activator (tPA), which was virtually absent in @entity463 multiforme (GBM), colon lung, and breast @entity3 , was found in normal quantities in @entity816 ( @entity816 ), @entity11 ( @entity11 ), and @entity1653 . @entity320 had significantly more tPA activity than normal brain did. A reverse correlation was found between tPA and MRI findings of @entity39 , enhancement, and @entity4 . Similarly, @entity1 with no detectable tPA activity had shorter survival than did @entity1 with detectable tPA activity. We conclude that high levels of @entity2290 and absent tPA activity correlate with histologically malignant @entity1313 , aggressive characteristics, and shorter survival.
