A XXXX -mediated inhibition of neurones in the nucleus tractus solitarius of the cat.

@entity1026 @entity1246 @entity2228 @entity4486 @entity1027
1. Extracellular recordings were made from 123 synaptically activated neurones in the nucleus tractus solitarius of the @entity4486 -anaesthetized cat. 2. Ninety-one neurones were activated by electrical stimulation of cardiac or pulmonary vagal branches and thirty-two by stimulation of the aortic nerve. 3. Ionophoretic application of @entity1246 abolished or markedly reduced the evoked or spontaneous activity of each neurone tested. These inhibitory effects were antagonized by the simultaneous ionophoretic application of @entity1027 . 4. @entity2228 inhibited the evoked activity of 60% of neurones tested. This inhibition could be antagonized by the simultaneous application of @entity1026 . 5. Application of @entity1027 alone increased the evoked or spontaneous activity of a large proportion of the neurones; @entity1026 alone had no significant effect on the evoked or spontaneous activity of the neurones. 6. These results are consistent with the hypothesis that @entity1246 acts as an inhibitory transmitter substance within the nucleus tractus solitarius.
