XXXX in @entity1 : Implications for Health and Disease.

@entity1 @entity308 @entity1025 @entity31566 @entity565 @entity1272 @entity784 @entity2704 @entity23631 @entity1468 @entity23996 @entity972 @entity453 @entity57449 @entity1760
UNASSIGNED: @entity1760 ( @entity1025 ) is an essential ion to the @entity1 body, playing an instrumental role in supporting and sustaining health and life. As the second most abundant intracellular cation after @entity972 , it is involved in over 600 enzymatic reactions including energy metabolism and protein synthesis. Although @entity1025 availability has been proven to be disturbed during several clinical situations, serum @entity1025 values are not generally determined in @entity1 . This review aims to provide an overview of the function of @entity1025 in @entity1 health and disease. In short, @entity1025 plays an important physiological role particularly in the brain, heart, and skeletal muscles. Moreover, @entity1025 supplementation has been shown to be beneficial in treatment of, among others, @entity1468 , @entity2704 , @entity308 , @entity453 , and @entity565 . Over the last decade, several hereditary forms of @entity1272 have been deciphered, including mutations in @entity31566 ( @entity31566 ), @entity23631 , and @entity57449 ( @entity57449 ). Recently, mutations in @entity1025 transporter 1 ( @entity23996 ) were linked to @entity784 underlining the important role of @entity1025 in cell viability. Moreover, @entity1272 can be the consequence of the use of certain types of drugs, such as diuretics, epidermal growth factor receptor inhibitors, calcineurin inhibitors, and proton pump inhibitors. This review provides an extensive and comprehensive overview of @entity1025 research over the last few decades, focusing on the regulation of @entity1025 homeostasis in the intestine, kidney, and bone and disturbances which may result in @entity1272 .
