Histology and biology of XXXX . Report of a case with a review of the literature.

@entity1 @entity5 @entity75 @entity3 @entity84 @entity204
This case report of a metastasizing @entity84 with a review of the literature was undertaken to gain a better understanding of the biologic behavior of this exceedingly rare @entity5 and thus to facilitate its clinical management. The lung was by far the most frequent metastatic site. Thus, all 7 @entity1 with a proven @entity3 recorded up to now including the present case had developed multiple pulmonary metastases. The interval between the initial diagnosis of the primary and manifestation of lung metastases proved to be long, with a mean of 8.4 years. The average survival time was at least 12.3 years. The mean interval between diagnosis of @entity3 and @entity204 amounted to at least 6.3 years. The histomorphologic features of @entity3 , its local recurrences and of the metastatic lesions differed in no way from conventional @entity84 . Because of the lack of cellular criteria of @entity5 it is impossible to predict the potential biologic behavior of @entity84 , in particular with respect to their ability to metastasize. However, the presence of @entity5 emboli in the @entity75 is highly suggestive of a subsequent development of @entity3 . The delayed induction of hematogenous metastases is best explained by a limited growth potential of the @entity5 cells. In case of a large @entity5 --especially in flat bones--with soft tissue invasion or in the presence of @entity5 emboli an aggressive surgical approach is suggested. When lung metastases have developed their surgical removal is recommended to hopefully prolong live expectancy or even to obtain a curative effect.
