Functional defect of B lymphocytes in a XXXX with selective IgM deficiency associated with @entity1252 .

@entity1 @entity19 @entity1252 @entity794 @entity1200 @entity18096 @entity792
@entity18096 ( @entity18096 ) is a rare @entity1200 , which is found in some @entity1 with @entity792 . The pathogenesis of @entity18096 and the relationship of these diseases have remained unclear. The absence of secreted IgM was recently reported to accelerate the development of @entity792 in lupus-prone lymphoproliferative (Ipr) @entity19 . The reduction of secreted IgM production may relate with the progression of @entity792 in @entity1 . We present a case of @entity18096 associated with @entity1252 ( @entity1252 ), and examined the function and the IgM heavy chain gene of @entity1 's lymphocytes. The number and the surface IgM expression of the @entity1 's B cells were normal. In vitro stimulation of peripheral mononuclear cells by recombinant IL-2 and a B cell activator, @entity794 Cowan strain I, could not overcome the reduction of IgM production, although the secreted form of IgM mRNA was detected. Sequence analysis of the IgM heavy chain gene and the IgM mRNA revealed no mutation or deletion. These findings suggested that @entity18096 in this case was involved in the abnormality during B cell maturation. Further analysis is required to reveal the pathogenesis of @entity18096 associated with @entity1252 .
