Motor responses of the urinary bladder and skeletal muscle in botulinum intoxicated XXXX .

@entity1617 @entity8431 @entity1167 @entity35 @entity5564 @entity912
1. Type A or type D botulinum toxin administered to @entity35 did not produce a generalized @entity912 of skeletal muscles at the time of @entity1167 . However, if survival was extended by artificial ventilation complete blockade of neuromuscular transmission developed 6.5 hr after 100 @entity8431 and 5 hr after 1000 @entity8431 of type A toxin. The onset of @entity912 of a muscle was shortened by repetitive stimulation of the motor nerves.2. There was no consistent blockade of parasympathetically innervated viscera in animals dying after type A toxin. Animals given type D toxin displayed @entity5564 and urinary retention before death.3. Motor responses to electrical stimulation, of bladder preparations in vitro were more vulnerable to type D than to type A toxin. When somatic @entity912 was complete in animals treated with type A or type D toxin the excised bladders produced pressure elevations 45 and 25%, respectively, of control preparations.4. During electrical stimulation of bladder preparations nearly paralysed by either toxin, the @entity1617 release was significantly diminished from controls. In the @entity35 bladder botulinum toxin specifically disrupted the liberation of mediator from post-ganglionic nerve endings.
