[Clinicopathological study of XXXX in the early stage and its later development].

@entity308 @entity2681 @entity5 @entity75 @entity189 @entity418 @entity6349
Ninety-five specimens taken from 82 cases of superficial @entity418 limited within the submucosal layer were studied to clarify the developmental changes of early @entity418 . Esophageal epithelium was also open to cancerous or @entity6349 changes. Cancers limited to the mucosal layer were grossly classified as follows. 1) those progressing to @entity189 in situ of several millimeters to 2-5 cm in size, then invading deep beyond the mucosa, and 2) those invading beyond the mucosal layer to proliferate before reaching several millimeters in extent. Most of the resected cases belonged to type 1. which was flat in form with @entity2681 or sclerohypertrophic appearance of the mucosa. These findings depended on the degree of cellular atypism and histological differentiation. Almost all @entity5 lesions less than 2 cm in size were of macroscopically protruding or depressed type. Many cases were simple type without intraepithelial spreading around the @entity75 and seemed to develop with in micro- @entity5 nests. Superficial circularly spreading @entity5 was one of the complex types observed with intraepithelial @entity5 around the @entity75 . Most superficial spreading cancers originating as large flat epithelial lesions, and the protrusions or @entity308 found in the lesions were considered to have developed as secondary changes occurring during the course of change. Vessel-invasion of superficial @entity418 was also discussed.
