Influence of @entity117 and XXXX on blood pressure and efficacy of antihypertensive drugs in spontaneously @entity101 @entity35 .

@entity1169 @entity1338 @entity101 @entity117 @entity2918 @entity34441 @entity35 @entity1281 @entity11848
The effects of the cyclooxygenase inhibitor @entity117 ( @entity1281 ) and of the TXA2 receptor antagonist @entity34441 on blood pressure and on the efficiency of antihypertensive drugs were investigated in spontaneously @entity101 @entity35 (SHR). @entity1281 and @entity34441 applicated once caused a significant, but short-lasting decrease in blood pressure in SHR. In contrast, repeated application of @entity1281 (3 x 100 mg/kg) caused a slight, but significant increase in blood pressure. Pretreatment with @entity34441 (60 mg/kg i.v.) did not influence the antihypertensive effect of the drugs @entity1338 , @entity1169 and @entity11848 . Pretreatment of SHR with @entity1281 intensified significantly the effect of these drugs on blood pressure, independent of their mode of action, and on heart rate ( @entity11848 ). The formation of TXB2 in the aorta thoracica in @entity1281 pretreated SHR 20 min after drug application, was more strongly inhibited than was the formation of PGI2. Therefore the TXA2/PGI2 balance shifted in favor of the latter. However, in normotensive @entity35 , @entity1281 was without any effect on blood pressure and on the antihypertensive efficacy of the drugs. In conclusion it could be suggested that @entity2918 are involved in the short term as well as in the long term regulation of the blood pressure and in the blood pressure lowering activity of drugs at least in a @entity101 state.
