XXXX diseases of pregnancy and parity.

@entity1 @entity4 @entity3036 @entity101
Chesley's classic long-term follow up study of eclamptic @entity1 clearly demonstrated the prognostic significance of parity in the differential diagnosis of various @entity101 diseases of pregnancy. Multiparous @entity1 with @entity3036 were different on long-term follow-up from primiparous eclamptic @entity1 . A logical conclusion from this observation is that multiparous and primiparous @entity1 groups should be analyzed separately whenever @entity101 diseases of pregnancy are evaluated. This study is therefore an attempt to define the clinical profile of @entity101 during pregnancy on the basis of parity alone. The prenatal and hospital records of 99 successive pregnant @entity1 identified as @entity101 during a 1-year period at Mount Sinai Hospital Medical Center served as the study population. A group of 25 primiparous and 25 multiparous @entity1 , all with uncomplicated pregnancies and normal deliveries in sequence during a 1-month period, served as normal nonhypertensive control groups. Various pregnancy parameters were statistically evaluated for study and control groups. Significant differences were found between @entity101 primiparous and multiparous @entity1 in mean weight increase (p less than 0.05), gestational age at first increase in blood pressure (p less than 0.007), and time from first increase in blood pressure until delivery (p less than 0.008). The difference in birth weight was not significant between @entity101 groups. In contrast, among the control groups, multiparous @entity1 had significantly larger offspring than primiparous @entity1 (p less than 0.01). Weights of normal primiparous control @entity1 were almost identical to those of primiparous @entity101 @entity1 (3252.8 +/- 511.8 versus 3203.26 +/- 679.5 gm). Birth weights of offspring from multiparous @entity101 @entity1 , while not significantly different from those of primiparous @entity101 @entity1 , were significantly lower than those of multiparous control subjects (3093.94 +/- 898.7 versus 3593 +/- 305.6; p less than 0.01). No significant differences in a variety of laboratory findings, reflexes, @entity4 , or mode of delivery were observed between the various groups. The clinical and laboratory presentation of @entity101 in pregnancy may be similar between primiparous and multiparous @entity1 . Nevertheless, clear differences do exist in both maternal presentation and impact of maternal disease on fetal growth and development. These differences strongly suggest a different pathophysiology as the underlying cause of @entity101 in primiparous and multiparous pregnant @entity1 .(ABSTRACT TRUNCATED AT 400 WORDS)
