Synthesis and Biological Activity of @entity3093 Derivatives from @entity13474 as Potent Anti- XXXX Agents.

@entity1 @entity6 @entity3093 @entity670 @entity7352 @entity505 @entity8108 @entity413 @entity13474
UNASSIGNED: A set of novel @entity3093 derivatives from @entity13474 were synthesized. The structures of derivatives were identified by proton nuclear magnetic resonance (  @entity8108 -NMR), @entity505 -13 ( @entity7352 )-NMR and mass spectrometry (MS) spectral analyses. Their anti- @entity6 activities were evaluated using an insulin-resistant (IR) HepG2 cell model. Additionally, the structure-activity relationships of these derivatives were briefly discussed. Compounds 1c, 2h, 3b, and 5 and @entity670 exhibited significant @entity413 consumption-enhancing effects in IR-HepG2 cells. In addition, the combinations of @entity670 , 2h, and 3b (combination 6) and of 3b, @entity670 , and 1c (combination 10) exhibited better anti- @entity6 activity than the individual compounds. At the same dosage, there was no difference in effect between the combination 10 and the positive control (p > 0.05). Aditionally, we found the differences between the combination 10 and combination 6 for the protective effect of HUVEC ( @entity1 umbilical vein endothelial cells) under high @entity413 concentration. The protective effects of combination 10 was stronger than combination 6, which suggested that combination 10 may have a better hypoglycemic activity in future studies. This study provides useful clues for the further design and discovery of anti- @entity6 agents.
