Induction of XXXX modulation in @entity19 @entity2040 mansoni by enteric exposure to schistosome eggs.

@entity99 @entity738 @entity19 @entity409 @entity1503 @entity281 @entity3512 @entity2040 @entity694
Enteric administration of antigen can induce systemic tolerance. In @entity19 @entity2040 mansoni, @entity1503 produce eggs which enter the intestine. An immunologic phenomenon associated with this disease is a spontaneous diminution in the intensity of the granulomatous response in the liver, lungs, and @entity694 with @entity281 , which is termed modulation. It was determined whether modulation of liver @entity738 could be induced by enteric immunization with schistosome eggs. @entity19 infected for 4 wk were immunized by injection of 25,000 eggs into cecal pouches. This induced modulation of liver @entity738 by the eighth week of @entity281 . Neither cecal injection of normal saline nor i.p. or subcutaneous injection of eggs could induce the modulatory process. Modulation could be adoptively transferred from enterically immunized donors by injection of spleen cells into infected recipients or into uninfected recipients with synchronous liver @entity738 induced by the @entity99 of schistosome eggs. Spleen cells treated with anti- @entity3512 or anti-Lyt-1.1 and complement could no longer adoptively transfer modulation. These data show that enteric immunization with schistosome eggs can induce modulation of the @entity409 by a cellular mechanism similar to that described for the natural @entity281 .
