Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe XXXX is dependent primarily upon female and not male factors.

@entity1 @entity6847 @entity4810
OBJECTIVE: To determine the efficacy and factors affecting outcome of @entity6847 ( @entity6847 ) in @entity1 with severe @entity4810 . DESIGN: Prospectively designed clinical trial of @entity1 selected to participate in the study based upon the following inclusion criteria: previous total failed fertilization or unsuitable sperm parameters for conventional IVF. SETTING: Tertiary care academic center. @entity1 : Ninety-two consecutive couples undergoing IVF therapy augmented with @entity6847 during April through December 1994 were studied. MAIN OUTCOME MEASURES: Fertilization and ongoing implantation and pregnancy rates (PRs). RESULTS: A total of 1,163 preovulatory oocytes were manipulated, yielding a diploid fertilization rate of 60.9%; the oocyte damage rate was 13.2%. The transfer rate was 95% with 43.1% of cycles having excess embryos that were cryopreserved. Overall, the clinical and ongoing PRs per transfer were 31.9% and 26.8%, respectively. None of the sperm parameters of the original semen analysis correlated with @entity6847 outcome. Female age did not affect fertilization results but had a significant impact on PR (< 34 years: 48.9%; 35 to 39 years: 22.9%; > or = 40 years: 5.9% clinical PR per transfer). CONCLUSIONS: Intracytoplasmic sperm injection offers a new and powerful therapeutic option to treat couples with severe @entity4810 associated with a variety of @entity6847 . An adequate female age is a pivotal factor determining a successful outcome.
