Ultrasound for assessment of diaphragm in XXXX .

@entity1 @entity2798 @entity13432 @entity746
OBJECTIVE: To evaluate the correlation between diaphragm thickness assessed by ultrasound (US) with respiratory function tests and the diaphragm motor responses, in @entity1 with @entity746 ( @entity746 ). METHODS: 42 consecutive @entity746 @entity1 were studied (11 with bulbar-onset), excluding @entity1 with marked orofacial paresis. Investigation included: revised @entity746 functional rating scale (ALSFRS-R), forced vital capacity (FVC), maximal @entity2798 (MVV), maximal inspiratory (MIP) and expiratory (MEP) pressures, nasal inspiratory pressure during sniff (SNIP); peak-to-peak amplitude of the diaphragmatic motor response to phrenic nerve stimulation (Diaphragm- @entity13432 ), diaphragmatic thickness measured by ultrasound during maximal inspiration and during maximal expiration. @entity1 were analysed in bulbar or spinal subgroups. Correlations and multiple linear regression models were studied. RESULTS: The mean age at disease onset was 58.4  11.1years and with a mean disease duration of 17.8  13.6months. Ultrasound studies of diaphragm thickness in full inspiration correlated with diaphragm @entity13432 in the whole population and in spinal-onset @entity1 ; and were similar in the two groups. Multiple linear modelling showed that FVC, SNIP and MVV were dependent on the change of thickness (p=0.001, 0.001 and 0.020, respectively) and that MIP and MEP were related to diaphragm @entity13432 p=0.003 and p=0.025, respectively). CONCLUSION: Diaphragm thickness correlates with Diaphragm- @entity13432 , except in bulbar-onset @entity1 . Respiratory tests are dependent on both diaphragm thickness and Diaphragm- @entity13432 . SIGNIFICANCE: US thickness of the diaphragm correlates with the number of functional motor units as assessed by the phrenic nerve motor amplitude.
