Underweight but metabolically abnormal phenotype: Metabolic features and its association with XXXX .

@entity1 @entity28 @entity633 @entity209 @entity65
BACKGROUND: Previous studies revealed that among @entity1 with normal and high body mass index (BMI), @entity209 contribute to the increased risk of @entity65 ( @entity65 ). However, studies investigating the metabolic features and its association with @entity65 are limited. METHODS: A national representative sample of adult population in China was used. Underweight was defined as BMI <18.5kg/m(2). @entity1 who had less than 2 criteria of @entity209 were classified as metabolically healthy; those who had 2 or more criteria of @entity209 were classified as metabolically abnormal. Presence of @entity65 and @entity633 were compared among groups stratified by BMI and metabolic status. RESULTS: Among 46308 @entity1 , 2267 (4.6%) were classified as underweight; and 372 (16.4%) of them were identified as metabolically abnormal. Metabolic features were comparable between underweight but metabolically abnormal @entity1 and @entity28 @entity1 . Compared with @entity1 with normal weight and normal metabolic features, the underweight but metabolically abnormal @entity1 were more likely to have @entity65 and @entity633 , with an adjusted odds ratio of 2.33 (95% confidence interval (CI) 1.34-4.05) and 2.56 (95% CI 1.86-3.52), respectively. Among underweight @entity1 , factors associated with metabolic abnormal phenotype included leisure time physical inactivity, mild occupational physical activity, and waist circumference. CONCLUSIONS: Metabolically abnormal phenotype is not rare among underweight population in China, and preventive strategy against @entity65 should also be considered in that population.
