Functional-morphologic correlations in assessing XXXX .

@entity1 @entity8 @entity581
Evaluation of the correlation of functional and morphologic assessments of @entity8 are obviously important to the toxicologic pathologist. All clinical assessments of the nephrotoxicity of drugs are based on renal function tests while preclinical assessments involve functional and/or morphologic assessments in laboratory animals. However, there are considerable concerns about the sensitivity of the tests available to monitor renal function. In an attempt to assess the relative sensitivity of functional and morphologic indicators of nephrotoxicity, three data bases were examined for their ability to rank the nephrotoxicity of the three most widely used @entity581 . The functional data base was comprised of reported comparative clinical trial data and the morphologic data base was composed of preclinical studies available in the literature which used morphology as the basis of comparison. A third data base involved biochemical or mechanistic comparisons of @entity581 and represented data that was not based on clinical function test results or morphologic analysis. When these three data bases were compared, it was obvious that clinical function tests could not discriminate between the nephrotoxic liability of the three @entity581 . The preclinical renal morphology data base and the biochemical mechanistic data base both clearly discriminated the drugs one from another and ranked the three @entity581 in the same order. Several conclusions were suggested by these results. Comparisons of the nephrotoxic potentials of drugs in @entity1 utilizing available renal function tests may be inconclusive primarily because clinical renal function tests are insensitive. Comparisons of the nephrotoxic liabilities of drugs in laboratory animals utilizing morphologic assessments of renal tissue damage may be the best comparison available.(ABSTRACT TRUNCATED AT 250 WORDS)
