Association of hyperlipidaemia, @entity32 and serological status and @entity301 among @entity1 with XXXX : data from the National Veterans Health Administration.

@entity1 @entity32 @entity64 @entity301 @entity583 @entity309 @entity165 @entity1851
OBJECTIVE: To examine the association of serum lipids, @entity32 and seropositivity on @entity301 ( @entity301 ) and @entity64 in @entity1 with @entity309 ( @entity309 ). METHODS: The incidence of hospitalised @entity583 ( @entity583 ) or @entity64 was calculated in a cohort of @entity1 with @entity309 receiving care within the national Veterans Health Administration from 1998 to 2011. Cox proportional hazard models were used to examine the association between these outcomes and low-density lipoprotein @entity165 (LDL-C), high-density lipoprotein @entity165 (HDL-C), @entity1851 (CRP) and erythrocyte sedimentation rate (ESR) as time-varying variables, divided into quintiles. RESULTS: There were 37   568 @entity1 with @entity309 in the cohort with mean age of 63   years (SD 12.1); 90% were @entity1 . There was a no clear association between LDL-C and @entity301 / @entity64 . Compared with lower HDL-C (<34   mg/dL), higher HDL-C (>= 54   mg/dL) was inversely associated with @entity583 (hazard ratio (HR)=0.68, 95% CI 0.55 to 0.85) and @entity64 (HR=0.69, 95% CI 0.50 to  0.96). Higher CRP >2.17   mg/dL (vs CRP <0.26   mg/dL) was associated with increased risk (HR=2.43, 95% CI 1.77 to  3.33) for @entity583 and 2.02 (95% CI 1.32 to 3.08) for @entity64 . ESR >47   mm/h compared with <8   mm/h had an HR 1.87 (95% CI 1.39 to  2.52) for @entity583 and 2.00 (95% CI 1.26 to 3.18) for @entity64 . The association between @entity583 was significant for @entity309 seropositivity (HR=1.23, 95% CI 1.03 to 1.48). CONCLUSIONS: In this predominantly older male @entity309 cohort, there was no clear association between LDL-C and @entity301 , whereas higher HDL-C was inversely associated with @entity583 and @entity64 . CRP and ESR were similarly associated with increase @entity583 risk and @entity64 , reflecting the prominent role of @entity32 in @entity301 risk in @entity309 .
