Longitudinal three-dimensional-T2WI-SPACE study on XXXX in cat corticospinal tract and underlying pathology changes.

@entity17 @entity18906 @entity2360 @entity6441 @entity468 @entity528
PURPOSE: To investigate the feasibility of T2W-SPACE technique in early detection of @entity2360 , the signal evolutions of degenerated corticospinal tract (CST) on T2W-SPACE, and their underlying pathological changes. MATERIALS AND METHODS: The @entity2360 model of the CST was established in 23 @entity468 through excision of cortical origins of the tract. Eight @entity468 were scanned with the T2W-SPACE technique at 8 sequential time points, i.e. 0 (before modeling), 2, 4, 6, 8, 10, 20 and 30 days after modeling, and then they were pathologically examined. The remaining 15 @entity468 (3 per group) also underwent pathological examination at 2, 4, 6, 10 and 20 days after modeling, respectively. The ratios of @entity18906 signal intensity (rT2s) between the affected and unaffected sides of CST were analyzed. RESULTS: During the first 4 days, SPACE could not detect any significant changes of the affected CST, although @entity528 was pathologically observed at the second day. From 6 to 10 days, the rT2s decreased monotonously, which is corresponded to histological findings of @entity17 and phagocyte proliferation. From 10 to 20 days, @entity18906 s kept relatively stable at a low level and started to recover after that; the pathological changes of this period was characterized by marked phagocytizing activities. CONCLUSION: SPACE technique can detect @entity6441 at an early stage, and the signal evolution is consistent with the pathological processes. J. Magn. Reson. Imaging 2015;42:1134-1143.
