Cost-effectiveness of diet and exercise interventions to reduce overweight and XXXX .

@entity1 @entity64 @entity101 @entity6 @entity571 @entity0 @entity28 @entity741 @entity299 @entity694 @entity703
OBJECTIVE: To analyze whether two dietary weight loss interventions--the dietary approaches to stop @entity101 (DASH) program and a low-fat diet program--would be cost-effective in Australia, and to assess their potential to reduce the disease burden related to excess body weight. DESIGN: We constructed a multi-state life-table-based Markov model in which the distribution of body weight influences the incidence of @entity64 , @entity741 , @entity101 @entity299 , @entity6 , @entity571 , @entity0 , @entity694 , @entity703 . The target population was the overweight and @entity28 adult population in Australia in 2003. We used a lifetime horizon for health effects and costs, and a health sector perspective for costs. We populated the model with data identified from Medline and Cochrane searches, Australian Bureau of Statistics published catalogues, Australian Institute of Health and Welfare, and Department of Health and Ageing. OUTCOME MEASURES: Disability adjusted life years (DALYs) averted, incremental cost-effectiveness ratios (ICERs) and proportions of disease burden avoided. ICERs under AUS 50,000 per DALY are considered cost-effective. RESULTS: The DASH and low-fat diet programs have ICERs of AUS 12,000 per DALY (95% uncertainty range: Cost-saving- 68,000) and AUS 13,000 per DALY (Cost-saving--130,000), respectively. Neither intervention reduced the body weight-related disease burden at population level by more than 0.1%. The sensitivity analysis showed that when @entity1 ' costs for time and travel are included, the ICERs increase to AUS 75,000 per DALY for DASH and AUS 49,000 per DALY for the low-fat diet. Modest weight loss during the interventions, post-intervention weight regain and low participation limit the health benefits. CONCLUSION: Diet and exercise interventions to reduce @entity28 are potentially cost-effective but have a negligible impact on the total body weight-related disease burden.
