Central action of XXXX .

@entity1169 @entity3160 @entity2515 @entity1425 @entity11054 @entity5521 @entity935 @entity910 @entity5333 @entity3826 @entity2915 @entity8364 @entity1768 @entity1767 @entity35 @entity4944 @entity2955 @entity5831
@entity1425 (A) administered in doses of 10, 50 and 100 micrograms/ @entity35 into the right lateral ventricle of the brain (i.v.c.) in @entity35 reduced the spontaneous and exploratory locomotor activity, decreased the body temperature, and increased the effects of narcotics. The reduction of the locomotor activity after A was antagonized by @entity5831 , alpha-MT, and @entity3160 . Total chemical destruction of catecholaminergic neurons and selective destruction of dopaminergic neurons caused increase in A-induced locomotor activity. A had no effect on the locomotor activity in @entity35 subjected to the action of @entity2515 , @entity2515 with @entity2955 , and @entity5333 or @entity1169 . In @entity35 treated with @entity5333 , @entity1169 , @entity11054 or subjected to selective destruction of noradrenalinergic neurons adrenaline decreased significantly the locomotor activity. A (10 micrograms) increased and in higher doses inhibited @entity4944 -induced @entity2915 . It potentiated @entity4944 and @entity3826 stereotypy and antagonized @entity8364 induced with @entity1767 or @entity1768 . In the despair test adrenaline reduced the duration of @entity910 . In doses of 0.1, 1.0 and 10 micrograms/kg i.v. A increased slightly the flexor reflex of the hind paw of spinal @entity35 . This action was antagonized by @entity5521 as well as by @entity1169 . In biochemical investigations it was demonstrated that A decreased the level of @entity935 in @entity35 brain but had no effect on its utilization. The obtained results indicate that A i.v.c. stimulated catecholaminergic receptors.
