Radiotherapy of early-stage XXXX : analysis of factors affecting prognosis.

@entity1 @entity602 @entity9212 @entity5
This study is a retrospective analysis of 134 @entity1 treated with radiotherapy at our hospital. The sample included 88 stage T1 and 46 stage T2 @entity1 . Sixty-two @entity1 had anterior commissure involvement, 37 @entity1 had impaired vocal @entity602 , and 24 @entity1 had supraglottic or subglottic extension. Irradiation was given, with the dose ranging from 60 to 72 Gy. Laryngectomy was the main salvage treatment for local recurrence. The 5-year initial and final local control rates were 71% and 83%, and the 10-year initial and final local control rates were 69% and 80%, comparable to the results of other series. The 5-year rate of overall survival with final larynx preservation was 77%. Multivariate analysis revealed that anterior commissure involvement is prognostic of a poor outcome in @entity1 with T1 @entity5 . Further subgroup analysis revealed that a fraction size of > 200 cGy could overcome the negative impact of anterior commissure involvement and significantly improve the 5-year local control rate in T1 @entity1 (100% at > 200 cGy versus 45% at < or = 200 cGy; p = .04). Subglottic extension of the @entity5 predicted poor outcome in T2 @entity1 . The 5-year local control rates of @entity1 with and without subglottic extension were 9% and 77%, respectively (p < .001). According to our results, radiotherapy with a fraction size of > 200 cGy is recommended for T1 disease with anterior commissure involvement. For @entity1 with @entity9212 and subglottic extension, radiotherapy alone produces poor results. Further improvement of outcomes by other treatment strategies needs to be investigated.
