The influence of @entity3352 on renal haemodynamics in sickle cell XXXX .

@entity1 @entity417 @entity1133 @entity2918 @entity1011 @entity3352
1. Glomerular filtration rate and effective renal blood-flow were normal in a series of @entity1 with sickle cell @entity417 . Fractional creatinine excretion and fractional @entity1133 excretion were increased. 2. During @entity3352 administration there were significant falls in glomerular filtration rate, effective renal blood-flow, @entity1011 clearance and @entity1133 clearance in the @entity1 with sickle cell @entity417 ; fractional @entity1133 excretion also fell markedly. In control subjects none of these variables changed after @entity3352 . 3. Serum concentration of @entity1133 rose markedly during @entity3352 administration in sickle cell @entity417 , owing to both the decrease in glomerular filtration rate and the increase in fractional @entity1133 reabsorption. 4. We conclude that @entity2918 have an important role in maintaining a normal glomerular filtration rate and effective renal blood-flow in sickle cell @entity417 . The abnormal @entity1133 handling in @entity1 with this disease remains to be elucidated.
