Mammary analog @entity189 of XXXX with high-grade histology arising in hard palate, report of a case and review of literature.

@entity3359 @entity5 @entity13820 @entity9604 @entity189 @entity3981 @entity3 @entity420
Mammary gland analog @entity189 (MASC) of @entity3359 is typically a @entity5 of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This @entity5 shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, @entity9604 - @entity13820 , with @entity189 of breast. Histologically, it is often mistaken as @entity3981 , @entity420 not otherwise specified, and other primary @entity5 . Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with @entity9604 - @entity13820 translocation arising in the hard palate of a 41 year-old adult. Interestingly, the @entity189 has lower grade than the original @entity5 which strongly support @entity5 . Most commonly, MASC arises from the parotid gland and less often in minor salivary glands. @entity3 is relatively uncommon and high-grade histology has only been reported in four cases with three of them arising from the parotid gland and the location of the fourth one has not been reported. This is the first case with high grade histology that arise from minor @entity3359 and it emphasizes the importance of molecular screening of @entity5 with high-grade histology for @entity9604 - @entity13820 translocation. In our literature of 115 cases that includes the current case, MASC occurred predominantly in adult with only a few cases under 18 years of age and a male to female ratio of 1.2:1. Parotid gland is more commonly affected but there is also significant occurrence in minor salivary glands. Except for the cases with high grade histology, the overall prognosis is good.
