Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute XXXX .

@entity788 @entity7362 @entity656 @entity39 @entity4 @entity1341 @entity520 @entity35
AIM: To investigate the effect of epidural anaesthesia (EA) on pancreatic microcirculation during acute @entity788 (AP). METHODS: AP was induced by injection of @entity7362 into the pancreatic duct of @entity35 . To realize EA, a catheter was introduced into the epidural space between T7 and T9 and @entity1341 was injected. Microcirculatory flow was measured by laser Doppler flowmetry. Arterial blood gas analyses were performed. At the end of the experiment (<or=5 h), pancreas was removed for histology. The animals were divided into three groups: Group 1 (n=9), AP without EA; Group 2 (n=4), EA without AP; and Group 3 (n=6), AP treated by EA. RESULTS: In Group 1, pancreatic microcirculatory flow prior to AP was 141+/- 39 perfusion units (PU). After AP, microcirculatory flow obviously decreased to 9+/- 6 PU (P<0.05). @entity520 developed with base excess (BE) of -14+/-3 mmol/L. Histology revealed extensive @entity4 and tissue @entity39 . In Group 2, EA did not significantly modify microcirculatory flow. BE remained unchanged and histological analysis showed normal pancreatic tissue. In Group 3, AP initially caused a significant decrease in microcirculatory flow from 155+/-25 to 11+/-7 PU (P<0.05). After initiation of EA, microcirculatory flow obviously increased again to 81+/-31 PU (P<0.05). BE was -6+/-4 mmol/L, which was significantly different compared to Group 1 (P<0.05). Furthermore, histology revealed less extensive @entity4 and @entity39 in pancreatic tissue in Group 3 than that in Group 1. CONCLUSION: AP caused dramatic microcirculatory changes within the pancreas, with development of @entity520 and tissue @entity39 . EA allowed partial restoration of microcirculatory flow and prevented development of @entity39 . Therefore, EA should be considered as therapeutic option to prevent evolution from @entity656 .
