Prevalence and prognostic impact of @entity740 in XXXX from a gender perspective: data from the SWEDEHEART register, a large Swedish prospective cohort.

@entity1 @entity8 @entity470 @entity740 @entity583
OBJECTIVES: Gender differences in prevalence and prognostic impact of @entity740 ( @entity740 ) in @entity583 ( @entity583 ) have been poorly evaluated. In @entity583 , female gender has been independently associated with an increased risk of mortality. @entity740 has been found to be an important prognostic marker in @entity583 . The aim of this study was to evaluate gender differences in prevalence and prognostic impact of @entity740 on short-term and long-term mortality. DESIGN: Prospective observational cohort study. SETTING: The national quality register SWEDEHEART was used. In the beginning of the study period, 94% of the Swedish coronary care units contributed data to the register, which subsequently increased to 100%. The glomerular filtration rate was estimated ( @entity470 ) according to Modification of Diet in @entity8 Study (MDRD) and Cockcroft-Gault (CG). @entity1 : All @entity1 with @entity583 registered in SWEDEHEART from the years 2003-2009 were included (37   991 @entity1 , 66% @entity1 ). MAIN RESULTS: @entity1 had 1.6 (MDRD) to 2.2 (CG) times higher multivariable adjusted risk of @entity740 . Half of the @entity1 had @entity740 according to CG. @entity740 was associated with 2-2.5 times higher risk of in-hospital mortality and approximately 1.5 times higher risk of long-term mortality in both genders. Each 10   mL/min decline of @entity470 was associated with an increased risk of in-hospital and long-term mortality (22-33% and 9-16%, respectively) and this did not vary significantly by gender. Both in-hospital and long-term mortality were doubled in @entity1 . After multivariable adjustment including @entity470 , there was no longer any gender difference in early outcome and the long-term outcome was better in @entity1 . CONCLUSIONS: Among @entity1 with @entity583 , female gender was independently associated with @entity740 . Reduced @entity470 was a strong independent risk factor for short-term and long-term mortality without a significant gender difference in prognostic impact and seems to be an important reason why @entity1 have higher mortality than @entity1 with @entity583 .
