Effects of a novel formulation of @entity28973 0.1% cream on skin barrier function in XXXX .

@entity483 @entity28973 @entity228 @entity111 @entity134 @entity195
OBJECTIVE: To determine the effect a novel formulation of @entity28973 cream on skin barrier function in subjects with @entity483 . DESIGN: The authors performed an open-label, investigator-blinded, side-by-side, controlled trial examining skin barrier function before and after a two-week course of a class I, super-potent topical steroid. SETTING: Outpatient university-based dermatology clinic in Portland, OR. SUBJECTS: Twenty-five subjects aged 12 or older with a diagnosis of moderate, severe, or very severe @entity195 were recruited for this study. INTERVENTION: @entity28973 0.1% cream, a novel formulation of a class I super-potent topical @entity134 was applied to all affected areas, except a control site, once daily for two weeks or until clear. The control target site was treated with the vehicle once daily. MAIN OUTCOME MEASURE(S): The study's primary outcome was change in skin barrier function as measured by basal transepidermal water loss (TEWL) in acute lesional skin from baseline as measured at two weeks. RESULTS: TEWL readings significantly decreased (reflecting improved barrier function) in both the active and control target sites. The active target site decreased 14.35+/-16 mg/cm2 per hour; 95 percent confidence interval, P<0.001. The control target site decreased 8.75+/-11.80 mg/cm2 per hour in 25 subjects; 95 percent confidence interval, P<0.001. Skin electrical capacitance also improved significantly, reflecting improved stratum corneum hydration with therapy. @entity111 , clinical severity, and quality of life scores all showed significant improvement by the end of the study. CONCLUSION: The authors have shown that short-term treatment with a novel formulation of 0.1% @entity28973 led to significantly improved barrier function as measured by basal TEWL in subjects with active moderate to severe @entity195 . These data suggest short-term treatment with @entity195 with a super-potent @entity228 improves skin barrier function.
