Modulation of @entity4457 therapy following early surgery for unilateral XXXX .

@entity1 @entity227 @entity231 @entity432 @entity4457
BACKGROUND: Stimulus deprivation @entity4457 is the principal cause of @entity227 in @entity1 with unilateral congenital @entity231 . Even if lensectomy is undertaken at an early age, intensive postoperative occlusion of the phakic eye is essential for the development of useful vision in the aphakic eye. Despite this, the optimum method of regulating occlusion therapy is uncertain. METHODS: Interocular acuity differences identified using clinical preferential looking techniques (Keeler cards) were used to regulate target levels of @entity432 in a prospective evaluation of 10 systemically, metabolically, and neurologically normal @entity1 in whom dense unilateral @entity231 was diagnosed before 8 weeks of age, and operated upon by 10 weeks. @entity432 levels were recorded each day by parents in a diary. The development of preferential looking acuity in the phakic and aphakic eye were compared with prediction intervals derived from observations on 43 normal @entity1 . RESULTS: Aphakic eye preferential looking acuities were within the normal range at last review in all but one @entity1 . Interocular acuity differences were < or = 0.5 octave in all @entity1 older than 1 year of age at last review, and > or = 1 octave in three of four @entity1 less than 1 year old at last review (Fisher exact p = 0.033). Phakic eye acuities were within the normal range in all @entity1 at all visits. CONCLUSION: Within the first 2 years of life, normal preferential looking acuity may be achieved in both eyes of @entity1 undergoing early surgery for unilateral congenital @entity231 if occlusion therapy is modulated according to interocular acuity differences quantified by clinical preferential looking techniques.
