Primary XXXX of the Lip: A Report of 48 Cases.

@entity1 @entity3136 @entity5 @entity1600 @entity3 @entity320 @entity1349
PURPOSE: @entity320 ( @entity320 ) is a rare @entity5 and well-established treatment protocols for it are in short supply. The objective of this study was to evaluate the outcome of treatment modalities and explore the prognostic factors. @entity1 AND METHODS: A retrospective chart review was performed on 48 @entity1 with primary @entity320 treated in the authors' hospital from January 1992 to November 2013. The clinical characteristics and treatment modalities were identified and correlated with the outcomes. RESULTS: The 5-year @entity1349 ( @entity1349 ) rate was 56.1%, and the rate of @entity1600 ( @entity1600 ) @entity3 was 46% (22 of 48). A @entity5 of at least 4  cm  (P  = .001), nodular types (P  = .003), and @entity1600 (P < .0001) were independent prognostic factors for @entity1349 . Twenty-five @entity1 died during follow-up, mainly from to neck recurrence (14 of 25). Chemotherapy significantly improved the 5-year @entity1349 rate in @entity1 with stage IV @entity320 (P  = .03), but not in those with stage III (P  = .8). CONCLUSIONS: @entity320 has a lower @entity1600 and distant @entity3 rate and a better prognosis than other @entity3136 . A long history of melanin pigmentation is a dangerous sign for all @entity1 , and smoking seems to be associated with @entity320 in male @entity1 . @entity5 size (>= 4  cm), nodular type, and @entity1600 positivity are poor prognostic factors. A wide excision with close observation is advocated as the primary treatment for stage III @entity320 . Adjuvant chemotherapy is useful for @entity1 with stage IV @entity5 , but not for those with stage III.
