A matched @entity1 -sibling study on the usage of @entity1443 and the subsequent development of @entity566 and XXXX .

@entity1 @entity565 @entity566 @entity56 @entity1443
A number of studies have suggested that intake of @entity1443 during pregnancy and during the first months of life is associated with an increased risk of childhood @entity565 . We aimed to determine the association between @entity1443 usage during pregnancy and the first 6 months of life, and childhood @entity566 (i.e. positive skin prick tests), @entity56 , and @entity565 , using a matched @entity1 -sibling study comparing @entity1 with @entity56 with their healthy siblings without any symptoms of @entity56 . @entity566 in @entity1 and their siblings was determined by skin prick tests. @entity1 having at least one positive skin prick test were considered to be @entity56 . Intake of @entity1443 was assessed by standardized, interviewer-administered, questionnaire. Nineteen pairs of @entity56 @entity1 vs. non- @entity56 siblings were compared to determine the risk factors for @entity56 , while 15 pairs of @entity56 @entity1 vs. @entity56 siblings were compared to determine the risk factors for @entity565 . Moreover, 33 pairs of @entity56 @entity1 vs. non-asthmatic siblings (with and without @entity566 ) were compared to determine the risk factors for @entity565 . In addition, 17 @entity56 siblings (without @entity565 ) were compared with 19 non- @entity56 siblings (without @entity565 ) to determine the risk factors for @entity566 . Usage of @entity1443 during pregnancy was associated with @entity56 (p = 0.03). Furthermore, usage of @entity1443 between birth and 6 months of age, and between 4 and 6 months of age, was also found to be associated with @entity56 (p = 0.008 and p = 0.03 respectively). Usage of @entity1443 during pregnancy and during the early months of life may play a role in the development of @entity56 and @entity56 in @entity1 . However, due to obvious ethical reasons, direct evidence for this association (i.e. a double-blind, prospective study) is not available.
