Low grade esophageal @entity1712 in adults: an unrecognized part of the spectrum of XXXX ?

@entity1 @entity1712 @entity2194 @entity5202 @entity2023 @entity565 @entity402 @entity354 @entity1282
BACKGROUND: @entity5202 ( @entity5202 ) is defined by a minimum of 15 eosinophils (eos) per @entity2194 ( @entity2194 ) on esophageal biopsy, along with esophageal symptoms and the exclusion of @entity354 ( @entity354 ). The clinical significance of fewer eosinophils is unknown. METHODS: Fifty-nine adult @entity1 without a previous diagnosis of @entity5202 with esophageal biopsies containing 1-14 eos per @entity2194 (low grade @entity1712 ) and 418 adult @entity1 with >= 15 eos per @entity2194 were identified by retrospective review. @entity1 were divided into group A (1-9 eos per @entity2194 ), group B (10-14 eos per @entity2194 ), and group C (>= 15 eos per @entity2194 ) with a chart review of clinical and demographic data. RESULTS: While @entity1282 and @entity402 ( @entity565 and @entity2023 ) were more common in @entity1 with >= 15 eos per @entity2194 (group C) than those with low grade esophageal @entity1712 (groups A and B) (93 vs. 88%, P  =  0.02), food impaction and heartburn occurred at an equal frequency across all @entity1 groups. Endoscopic findings were likewise similar between groups. Of the 14 @entity1 with low grade esophageal @entity1712 who underwent repeat endoscopy a mean interval of 42  weeks (range 8-118  weeks) later, five (36%) met conventional diagnostic criteria for @entity5202 of 15 or greater eos per @entity2194 . Follow-up in ten @entity1 treated with topical corticosteroids noted improvement in nine, with mean follow-up of 8  weeks (range 4-12  weeks). CONCLUSION: Some adult @entity1 with @entity1282 and less than 15 eos per @entity2194 have similar endoscopic findings and clinical course to @entity1 meeting the consensus definition of @entity5202 . Further evaluation of @entity1 with low grade esophageal @entity1712 is needed.
