Non-menopausal Status, High Nuclear Grade, Tumor Size >30 mm and Positive Resection Margins Are Predictors of XXXX After Lumpectomy for Ductal Carcinoma In Situ of the Breast.

@entity1 @entity3821 @entity0 @entity41
AIM: Breast-conserving surgery with radiation therapy is the primary treatment for @entity3821 ( @entity3821 ). Re-excision is indicated when clear resection margins have not been achieved, although in some cases the procedure may be unnecessary as there is no @entity41 . The purpose of our three-Center retrospective study was to identify predictors of positive re-excision findings following breast-conserving surgery for @entity3821 . @entity1 AND METHODS: A total of 285 @entity1 underwent re-excision following conservative treatment for @entity3821 between 01/01/08 and 12/31/13 at three @entity0 referral Centers. We conducted a retrospective, comparative review of the factors that differentiated @entity1 with a @entity41 from those without. The study was based on clinical, radiological, surgical and pathological criteria. RESULTS: A total of 180 @entity1 (63%) had @entity41 after conservative treatment. Six factors were predictive on univariate analysis: young age (p=0.025), non-menopausal status (p=0.016), absence of preoperative biopsy (p=0.0029), high nuclear grade (p=0.0181), lesion size >30 mm (p=0.032), and positive surgical margins (p=0.0016). Four factors remained independently predictive on multivariate analysis: non-menopausal status (p=0.0017), high nuclear grade (p=0.0031), lesion size >30 mm (p=0.012) and positive surgical margins (p=0.0013). We calculated a 93% probability of positive re-excision findings if all four factors were combined. On the other hand, if none of the factors were present, the rate fell to 18%. CONCLUSION: In cases of @entity3821 , where risk factors for both involved lumpectomy margins and recurrence are carefully studied, knowledge of the risk factors for @entity41 can help guide therapeutic choices.
