Transarterial chemoembolization is ineffective for XXXX metastatic to the caudate lobe: a single institution review.

@entity1 @entity5
BACKGROUND: Caudate lobe liver metastases occur commonly in @entity1 with @entity5 . It is unknown, however, how these lesions respond to regional therapy and how their presence impacts outcomes. We reviewed our experience treating these lesions using transarterial chemoembolization (TACE). METHODS: We reviewed radiographic response to TACE in 86 @entity1 with metastatic @entity5 to the liver. We determined the impact of caudate lesions on outcomes in comparison to the cohort of @entity1 without caudate lesions, as well as response of caudate lesions to TACE versus lesions elsewhere in the liver. RESULTS: Caudate lesions were identified in 45 (52%) @entity1 . All @entity1 had disease in other liver segments. Only seven caudate lesions (12.3%) had a radiographic response to TACE, whereas 82% of lesions elsewhere in the liver demonstrated a response. The presence or absence of a caudate lesion did not impact the overall radiographic (82.2% vs. 82.9%), symptomatic (64.4% vs. 56.1%), or biochemical (97.6% vs. 88.9%) response to TACE (P   >   0.1 for all). However, median overall survival was reduced in those presenting with caudate lesions (87.1 vs. 45.6  months, P   =   0.031). CONCLUSIONS: Metastatic @entity5 to the caudate lobe respond poorly to TACE. Symptomatic or threatening caudate lobe lesions should be considered for palliative resection in spite of additional inoperable liver metastases.
