Weight loss in massive @entity28 : reciprocal changes in plasma HDL XXXX and HDL binding to @entity1 adipocyte plasma membranes.

@entity1 @entity353 @entity28 @entity9478 @entity412 @entity9477 @entity165
@entity1 @entity28 is frequently associated with elevated plasma @entity412 and @entity165 concentrations and reduced high density lipoprotein (HDL) @entity165 , abnormalities that commonly revert to normal levels with @entity353 . This study was undertaken to examine possible mechanism(s) associated with the changes in plasma HDL @entity165 concentrations in massively @entity28 @entity1 after @entity353 . Ten massively @entity28 @entity1 (two @entity1 and eight @entity1 , age = 37.8 +/- 2.4 years) were studied before, during, and after 1 year of @entity353 and weight maintenance following gastric stapling. Total @entity165 and low density lipoprotein @entity165 were within the normal range for sex and age before @entity353 and did not change significantly during or after @entity353 . In the females, HDL @entity165 concentrations increased from 0.96 +/- 0.06 mmol/L to 1.23 +/- 0.3 mmol/L (mean +/- SEM, n = 8, P less than .05) with @entity353 . In the two @entity1 , plasma HDL @entity165 concentrations were, respectively, 1.22 and 0.65 mmol/L before and 1.23 and 0.98 mmol/L after @entity353 . Specific binding of 125I- @entity9477 and 125I- @entity9478 to purified plasma membranes was determined using abdominal and omental fat depot before and after @entity353 in six of the ten @entity28 @entity1 . An average reduction of 30% to 40% in 125I- @entity9477 and 125I- @entity9478 binding capacity to these membranes occurred after @entity353 . Furthermore, a positive correlation (r = .65, n = 10, P less than .05) was observed between plasma HDL @entity165 and @entity412 concentrations before @entity353 but not after @entity353 (r = .01).(ABSTRACT TRUNCATED AT 250 WORDS)
