Nutrition and anabolic pharmacotherapies in the care of burn XXXX .

@entity1 @entity308 @entity73 @entity2495 @entity130
@entity130 is a devastating injury that results in a number of pathological alterations in almost every system in the body. @entity2495 , muscle wasting, @entity308 immunity, and @entity73 are all clinical features of burns. Failure to address each of these specific pathological alterations can lead to increased mortality. Nutrition supplementation has been recommended as a therapeutic tool to help attenuate the @entity2495 and devastating catabolism evident following burn. Despite the wide consensus on the need of nutrition supplementation in burn @entity1 , controversy exists with regard to the type and amount of nutrition recommended. Nutrition alone is also not enough in these @entity1 to halt and reverse some of the damage done by the catabolic pathways activated following severe @entity130 . This has led to the use of anabolic pharmacologic agents in conjunction with nutrition to help improve @entity1 outcome following @entity130 . In this review, we examine the relevant literature on nutrition after @entity130 and its contribution to the attenuation of the postburn @entity2495 response, @entity73 , and suppressed immunological responses. We also review the commonly used anabolic agents clinically in the care of burn @entity1 . Finally, we provide nutrition and pharmacological recommendations gained from prospective trials, retrospective analyses, and expert opinions based on our practice at the Ross Tilley Burn Center in Toronto, Canada.
