Conservative Treatment Seems the Best Choice in XXXX .

@entity1 @entity15709 @entity1082
OBJECTIVE: To study diagnostic and therapeutic strategies, outcomes, and follow-up in a large series of @entity1 with @entity15709 ( @entity15709 ) of the uterine cervix and investigate if @entity1082 ) typing among @entity1 with negative cytology reports would have helped with early @entity15709 detection. MATERIALS AND METHODS: Records of 132 @entity15709 cases diagnosed between 1989 and 2012 were retrieved. Clinical and pathological data were reviewed and analyzed. RESULTS: Mean age at diagnosis was 37 years. Seventy-two percent (n = 95) of all @entity1 were asymptomatic; diagnosis was established using cytology and biopsy. Primary treatment for 124 patents was cold knife cone or loop electrosurgical excision procedure (LEEP). Positive margins were found in 18% of those @entity1 treated with CKC versus 40% in those treated with LEEP. The mean follow-up time was 62 months (range, 2-217 months; median, 46 months). Three recurrences were found after conservative treatment in 86 @entity1 . High-risk HPV (hrHPV) positivity was detected in 115 (96%) of 120 @entity1 , with HPV-18 being the most commonly occurring subtype (51%). CONCLUSIONS: There is a small risk of relapse after conservative therapy with cold knife cone or LEEP when resection margins are negative in @entity1 with @entity15709 . @entity1 should be given the options of hysterectomy or conservative therapy with strict follow-up.
