Postprandial @entity1254 and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy XXXX .

@entity1 @entity1476 @entity1674 @entity1254 @entity1495 @entity413 @entity165
OBJECTIVE: Evidence suggests that an acute systemic inflammatory response is invoked after consumption of a high-energy meal. Postprandial regulation of @entity1254 , an adipose tissue-derived, anti-inflammatory hormone, and the gelatinases, @entity1476 and @entity1495 , endopeptidases implicated in a diverse range of inflammatory processes, remain inconclusive. The aim of this study was to assess the postprandial effect of a high-energy (1212  kcal) meal on plasma @entity1254 , @entity1476 and @entity1495 activity, @entity413 , insulin, @entity1674 , total @entity165 , high-density lipoprotein @entity165 , and the differential effects on these parameters depending on whether the test meal was high fat (HF; 46  g fat, 1210  kcal) or isoenergetic and low fat (LF; 15  g fat, 1214  kcal energy). METHODS: Test meals were consumed by 17 lean, healthy @entity1 on two separate occasions with blood samples collected by venipuncture at baseline (0  h) and 1 and 3  h after consumption of each test meal. RESULTS: At baseline, no significant difference was seen in the parameters between the two groups, except for @entity1476 , @entity1495 , and total @entity165 . Over the 3-h postprandial period, no significant differential effect of the HF versus the LF test meal was observed on @entity1254 , @entity1476 , @entity1495 , or on metabolic markers other than @entity1674 , which increased significantly in response to the HF test meal (time  *  treatment, P  =  0.002). When analyzed independent of time, @entity1476 (treatment, P  =  0.006), @entity1495 (treatment, P  =  0.022), and @entity413 (treatment, P  =  0.026) were lower after consumption of the HF meal compared with the LF test meal. When analyzed independent of treatment, @entity1254 increased over the 3-h postprandial period (time, P  =  0.031), but there was no change in @entity1476 or @entity1495 (time, P  =  0.503 and P  =  0.525, respectively). Over the 3-h postprandial period, insulin (time, P  <  0.001) and total @entity165 (time, P  =  0.002) increased, whereas @entity413 (time, P  <  0.001) and high-density lipoprotein @entity165 (time, P  <  0.001) decreased. CONCLUSION: No differential effects of a HF versus a LF isoenergetic meal were seen on postprandial @entity1254 or the gelatinases. @entity1254 increased in response to a high-energy meal independent of treatment, and the gelatinases were lower in response to the HF versus the LF isoenergetic meal, independent of time point. Given the considerable amount of time that @entity1 spend in the postprandial state, additional research is necessary to further understand inflammatory changes in this state.
