Acceleration of the proliferative activity of @entity418 with invasion beyond the muscularis mucosae; immunohistochemical analysis using XXXX for the Ki-67 antigen.

@entity1697 @entity894 @entity5 @entity957 @entity1721 @entity189 @entity13712 @entity418 @entity3 @entity1758
@entity957 of the esophagus with @entity5 invasion beyond the muscularis mucosae is known to have lymph node @entity3 and lymphatic or blood vessel invasion compared with @entity189 . In submucosal and T2-3 @entity189 , lymph node and lymphatic/vascular involvement are shown more frequently, leading to a poor prognosis. Therefore, we examined proliferative activity of @entity1721 including @entity189 in relation to clinicopathological findings. 77 cases of @entity1721 , including 23 cases of @entity1697 (Tis+ @entity13712 ), 35 cases of @entity189 (T1b) and 19 cases of advanced @entity189 (T2+T3) undergoing surgical resection without preoperative treatment were studied using monoclonal antibody @entity1758 for Ki-67 antigen immunohistochemically, and the @entity894 ( @entity894 ) was calculated. The @entity894 of @entity1758 positive nuclei correlated with the depth of @entity5 invasion was significantly increased in the @entity5 invading beyond the musculais mucosae. The @entity894 at the invasive tip was significantly higher than that at the core of differentiated @entity189 . The @entity894 values at both invasive tip and core of poorly differentiated @entity189 were higher than those of differentiated @entity189 with significant difference. The @entity894 at the invasive @entity189 with lymph node @entity3 or lymphatic invasion was significantly higher than that without them. Proliferative activities of @entity418 cell, immunostaining with @entity1758 , had correlations to depth of @entity5 invasion, differentiation, lymph node @entity3 and lymphatic invasion with significant difference. But if invading deeper than m3, the proliferative activity did not increase anymore.
