Detection of the @entity517 oncogene product in XXXX .

@entity1 @entity1127 @entity5 @entity517 @entity6523 @entity694 @entity6349 @entity1586
The @entity517 oncogene has been implicated in the processes of normal cell proliferation and differentiation. Elevated levels of @entity517 mRNA and its gene product (p62c-myc), have been detected in a variety of solid @entity5 and cultured cel lines. Its precise role in normal cell function and in neoplastic transformation and progression has yet to be elucidated. We have used a monoclonal antibody, raised by peptide immunisation, to determine the distribution by immunoperoxidase staining of the @entity517 oncogene product in archival specimens of @entity1586 . Samples from 42 @entity1 with @entity694 , 24 with benign @entity1127 and 15 normal colon biopsies were examined. Normal colon revealed maximum staining in the mid-zone of the crypts, corresponding to the zone of differentiation and maturation. The staining was predominantly cytoplasmic. @entity6523 revealed the most intense pattern of staining in areas of @entity6349 change. @entity5 showed a wide range of staining. Well differentiated @entity5 contained more cytoplasmic p62c-myc than poorly differentiated @entity5 . These findings suggest that the @entity517 oncogene product may play an important role in the evolution of @entity694 .
