Lipoprotein subclasses and coronary artery calcium in postmenopausal XXXX from the healthy @entity1 study.

@entity1 @entity1674 @entity729 @entity65 @entity165
Lipoprotein subclass levels may improve the prediction of @entity65 ( @entity65 ) in individuals beyond the risk assessment provided by conventional enzymatically determined lipid levels. The objective of this study was to evaluate the associations between nuclear magnetic resonance (NMR) spectroscopy-determined lipoprotein subclasses and coronary calcification in postmenopausal @entity1 , and to determine whether the associations were independent of conventional lipid measures. @entity729 ( @entity729 ) was measured by electron beam computed tomography, and lipoprotein subclasses were determined by NMR spectroscopy (Liposcience, Inc., Raleigh, NC), in 286 healthy @entity1 (mean age = 61.7), at 8 years postmenopause. @entity729 was analyzed as categories 0, 1 to 99, and > or =100. The mean @entity729 was 53 (range, 0 to 1,175), and 54% of the @entity1 had 0 scores. Large high-density lipoprotein (HDL) was inversely associated with @entity729 category, but small HDL was not. All very low-density lipoprotein (VLDL) subclasses-small, medium, and large-were positively associated with @entity729 (p <0.01). Small low-density lipoprotein (LDL) was positively associated with @entity729 (p <0.01), but medium and large LDL were not. Smaller LDL particle size (p <0.01) and higher levels of LDL particles (p <0.001) were associated with higher @entity729 category. In separate ordinal logistic regression models, small LDL, LDL particles, and large VLDL were each positively associated (p <0.05) with higher @entity729 after adjustment for age, systolic blood pressure (SBP), current smoking, and conventional measures of LDL @entity165 , HDL @entity165 , and @entity1674 . These results suggest that the measurement of lipoprotein subclasses may improve the prediction of @entity65 in postmenopausal @entity1 beyond that provided by the conventional lipid panel and @entity65 risk factors.
