Trends in frequency of XXXX in Japan from 1965-1979 to 1982-1986.

@entity5 @entity189 @entity263 @entity1762
By analyzing serial step-sections of whole prostate obtained at autopsy, we determined the chronologic change of the frequency of latent @entity263 in Japan in two periods: 1965-1979 and 1982-1986. Methods of specimen preparation and examination were identical for both periods. The frequency with which @entity263 was found in the 660 samples for 1982-1986 was 34.6% and was significantly higher than the 22.5% seen in the 576 observed for 1965-1979 (P less than .0001). This significant finding can be attributed to an increase in the frequency of @entity5 ( @entity5 ). However, the increase in the frequency of noninfiltrative @entity5 (LNT) was less significant (P = .045). Both sets of specimens were subsequently combined and reanalyzed according to the year of birth of the decedents. The @entity5 has progressively increased in frequency in each age-specific category. By morphometry, we determined that the mean @entity5 volume decreased due to an increase in the number of smaller @entity5 during the study periods. Although the frequency of @entity263 and the @entity5 :LNT in the samples obtained most recently were comparable to those of U. @entity1762 , @entity5 incidence and mortality rates remain lower in Japan. Apparently, the initial step in the induction of @entity263 in indigenous Japanese is now similar to that in U. @entity1762 . The rates of clinical @entity189 in Japan are still low when compared with those in the United States and countries in Western Europe, but our findings may presage a time when these differences may be greatly reduced or nonexistent.
