Plasma and tissue XXXX and TPA markers in operable @entity0 . Preliminary results.

@entity1 @entity0 @entity5 @entity787 @entity865
@entity787 and TPA were studied in sera and in histologic specimens of 200 @entity1 with benign (77) or malignant (123) breast pathology. The frequency and expression of the two markers was different in benign and in @entity5 tissues. Histologic positivity and high levels of circulating markers were observed more frequently in @entity5 @entity1 than in @entity1 with benign disease. Tissue positivity for the two @entity5 markers did not always correlate with elevated levels of circulating markers. Positive @entity787 and TPA incidence was higher in tissue samples than in serum samples. In the @entity0 group, among 33 @entity1 with histologic positivity for @entity787 , only 5 cases had circulating @entity787 levels higher than 5 ng/ml; among 91 @entity1 with histologic positivity for TPA, only 45 cases showed circulating levels for TPA higher than 95 U/l. These findings confirm that @entity5 size, secretory characteristics and vascular supply are factors affecting the achievement of high circulating marker levels. Combined marker measurement in serum and tissues can provide more information about the presence of a given @entity5 marker. A limited evaluation of the prognostic meaning of the study of combined @entity787 and @entity865 in sera and in tissues was carried out during the follow-up of 60 evaluable @entity1 . Only 5 @entity1 had @entity5 relapses in the first 12 months from surgery; in 2 of 5 @entity1 TPA was positive initially and at the time of recurrence, in serum as well as in tissues. Circulating @entity787 gave negative findings in all relapsed @entity1 ; 2 of them showed weak positivity only in the histologic staining at the time of presentation.
