The relationship between telomere length and clinicopathologic characteristics in XXXX among Tunisian @entity1 .

@entity1 @entity5 @entity3207 @entity14 @entity105
Alterations in telomere dynamics have emerged as having a causative role in @entity105 . Both the telomere attrition contribute to @entity5 initiation via increasing chromosomal instability and that the telomere elongation induces cell immortalization and leads to @entity5 progression. The objectives of this study are to investigate the dynamics of telomere length in @entity14 ( @entity14 ) and the clinicopathological parameters implicated. We measured the relative telomere length (RTL) in cancerous tissues and in corresponding peripheral blood leukocytes (PBL) using quantitative PCR (Q-PCR) from 94 @entity1 with @entity14 . Telomere length correlated significantly in @entity5 tissues and corresponding PBL (r   =   0.705). Overall, @entity5 tissue had shorter telomeres than PBL (p   =   0.033). In both @entity5 tissue and PBL, the RTL was significantly correlated with age groups (p   =   0.008 and p   =   0.012, respectively). The RTL in @entity5 tissue was significantly longer in @entity5 (p   =   0.04) and in the late stage of @entity5 (p   =   0.01). In PBL, the RTL was significantly correlated with the macroscopic aspect of @entity5 (p   =   0.02). In addition, the telomere-length ratio of @entity5 to corresponding PBL increased significantly with late-stage groups. Shortening of the telomere was detected in 44.7  %, elongation in 36.2  %, and telomeres were unchanged in 19.1  % of 94 @entity5 . Telomere @entity3207 occurred more frequently in the early stage of @entity5 (p   =   0.01). This study suggests that the telomere length in PBL is affected by the macroscopic aspect of @entity5 and that telomere length in @entity5 tissues is a marker for progression of @entity14 and depends on @entity5 -origin site.
