Wound Healing Effects of Rose Placenta in a XXXX Model of Full-Thickness Wounds.

@entity19 @entity641 @entity6354 @entity5231 @entity1611
BACKGROUND: Rosa damascena, a type of herb, has been used for wound healing in Eastern folk medicine. The goal of this study was to evaluate the effectiveness of rose placenta from R. damascena in a full-thickness wound model in @entity19 . METHODS: Sixty six-week-old C57BL/6 @entity19 were used. Full-thickness wounds were made with an 8-mm diameter punch. Two wounds were made on each side of the back, and wounds were assigned randomly to the control and experimental groups. Rose placenta (250   g) was injected in the experimental group, and normal saline was injected in the control group. Wound sizes were measured with digital photography, and specimens were harvested. Immunohistochemical staining was performed to assess the expression of @entity6354 ( @entity6354 ), @entity1611 ( @entity1611 ), @entity641 ( @entity641 ), and @entity5231 . Vessel density was measured. Quantitative analysis using an enzyme-linked immunosorbent assay (ELISA) for @entity6354 was performed. All evaluations were performed on postoperative days 0, 2, 4, 7, and 10. Statistical analyses were performed using the paired t-test. RESULTS: On days 4, 7, and 10, the wounds treated with rose placenta were significantly smaller. On day 2, @entity1611 and @entity6354 expression increased in the experimental group. On days 7 and 10, @entity641 expression decreased in the experimental group. On day 10, vessel density increased in the experimental group. The increase in @entity6354 on day 2 was confirmed with ELISA. CONCLUSIONS: Rose placenta was found to be associated with improved wound healing in a @entity19 full-thickness wound model via increased @entity6354 release. Rose placenta may potentially be a novel drug candidate for enhancing wound healing.
