Alterations of carboxypeptidases N activities in XXXX with thyroid dysfunction.

@entity1 @entity1375 @entity1378 @entity17470 @entity18086
Serum carboxypeptidases N (EC. 3.4.17.3) were determined spectrophotometrically in 87 @entity1 with disturbances of thyroid function and in 131 euthyroid individuals, including 33 @entity1 taking estrogens for contraception. Carboxypeptidases N (CN) can be subdivided into @entity17470 and @entity18086 , according to variable substrate affinity. In addition, measurements of blood pressure and in vitro tests of thyroid function were performed. In euthyroid controls, @entity17470 was negatively correlated with age. No significant differences between @entity17470 and @entity18086 have been observed with regard to sex. In @entity1 with @entity1378 , the mean values of both enzymes were elevated, but this tendency proved to be significant only for @entity18086 . In @entity1375 @entity1 @entity17470 and @entity18086 levels were normal. Elevations of @entity17470 and @entity18086 in the @entity1378 state seem not to be related to underlying immunological processes but to the thyroid hormone excess itself. In euthyroid @entity1 taking estrogens for contraception @entity18086 was also elevated.
