Effects of repeated @entity12781 administration on adult hippocampal neurogenesis in the XXXX .

@entity1 @entity1603 @entity146 @entity12781 @entity73 @entity212 @entity161 @entity716 @entity35 @entity4944 @entity2055
Dysfunctional maturation of neural networks, particularly hippocampus-prefrontal networks, may be of particular interest in determining the pathophysiology of @entity161 . @entity12781 ( @entity212 )-induced symptoms in @entity1 appear to offer a more complete model of @entity161 than do @entity4944 -induced symptoms. This study investigated the effects of intermittent i.p. injections of @entity212 (7.5 mg/kg) on cell proliferation and survival of granule cells in the dentate gyrus of the @entity35 brain using quantitative immunohistochemical techniques for @entity1603 ( @entity1603 )-positive cells. After repeated @entity212 injection for 14 days, mean scores for stereotyped behavior increased with the number of injections, while scores for @entity2055 and backpedaling as serotonergic behaviors gradually decreased. The number of @entity1603 -positive cells decreased by 23% in the subgranular zone of the dentate gyrus by 24 h after repeated injections. However, decreased levels of @entity1603 -positive cells returned to control levels within 1 week. Differentiation of newly formed cells was not influenced. Repeated @entity212 administration after @entity1603 injection did not exert any effects on survival of newly generated cells. These findings suggest that transient disturbances of cell proliferation in the dentate gyrus occur under @entity212 -related @entity146 . Whether disturbed cell proliferation would thus be closely implicated in the development of behavioral sensitization induced by @entity212 administration is unclear, but this would possibly result from adaptation to new pharmacological conditions under behavioral sensitization or stressful conditions of @entity212 -related abnormal behaviors. Further studies are required to elucidate the biological significance of hippocampal neurogenesis in the mechanisms underlying the development of @entity73 and the @entity716 of @entity161 .
