XXXX in the elderly: risk factors and outcomes.

@entity1 @entity4988 @entity303 @entity73 @entity1514 @entity260 @entity933
OBJECTIVE: The purpose of this study was to describe the natural history, identify risk factors, and determine outcomes for the development of @entity260 in the elderly. BACKGROUND: @entity260 is a common and deleterious complication in geriatric @entity1 . METHODS: Subjects older than 50 years scheduled for an operation requiring a postoperative intensive care unit admission were recruited. After preoperative informed written consent, enrolled subjects had baseline cognitive and functional assessments. Postoperatively, subjects were assessed daily for @entity933 using the confusion assessment method-intensive care unit. @entity1 were also followed for outcomes. RESULTS: During the study period, 144 @entity1 were enrolled before major abdominal (40%), @entity1514 (53%), or vascular (7%) operations. The overall incidence of @entity933 was 44% (64/144). The average time to onset of @entity933 was 2.1 +/- 0.9 days and the mean duration of @entity933 was 4.0 +/- 5.1 days. Several preoperative variables were associated with an increased risk of @entity933 including older age (P < 0.001), @entity4988 (P < 0.001), impaired functional status (P < 0.001), pre-existing @entity303 (P < 0.001), and pre-existing comorbidities (P < 0.001). In a multivariable logistic regression model, pre-existing @entity303 remains the strongest risk factor for the development of @entity260 . Worse outcomes, including increased length of stay (P < 0.001), postdischarge institutionalization (P < 0.001), and 6 month mortality (P = 0.001), occurred in subjects who developed @entity933 . CONCLUSIONS: In the current study, @entity933 occurred in 44% of elderly @entity1 after a major operation. Pre-existing @entity73 was the strongest predictor of the development of @entity260 . Outcomes, including an increased rate of 6 month mortality, were worse in @entity1 who developed @entity260 .
