Therapeutic targeting of @entity16221 -catenin signaling reduces @entity5 stem-like population and synergistically suppresses growth of EBV-positive XXXX cells with @entity900 .

@entity3373 @entity16221 @entity5 @entity900 @entity189 @entity3493 @entity4731 @entity3546 @entity1759 @entity3 @entity72191
UNASSIGNED: @entity189 ( @entity189 ) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant @entity5 stem cells (CSC) may associate with @entity5 relapse and @entity3 in @entity189 . @entity72191 is a specific @entity16221 -catenin antagonist that can block @entity16221 -catenin-mediated transcription of stem cell associated genes and enhance @entity3493 / @entity3546 -mediated transcription, thereby reducing the CSC-like population via forced differentiation. In this study, we aimed to evaluate the effect of @entity72191 on the CSC-like population, and the combination effect of @entity72191 with @entity900 in the C666-1 EBV-positive @entity189 cells. Results showed that @entity72191 inhibited C666-1 cell growth and reduced expression of CSC-associated proteins with altered expression of epithelial-mesenchymal transition (EMT) markers. @entity72191 also inhibited C666-1 @entity5 sphere formation, accompanied with reduced @entity4731 (hi)/ @entity1759 (hi) CSC-like population. @entity72191 was also found to restore the expression of a @entity5 suppressive microRNA-145 ( @entity3373 ). Ectopic expression of @entity3373 effectively repressed @entity4731 protein expression and inhibited @entity5 sphere formation. Combination of @entity72191 with @entity900 synergistically suppressed in vitro growth of C666-1 cells and significantly suppressed growth of @entity189 xenografts. These results suggested that therapeutically targeting of the @entity16221 -catenin signaling pathway with @entity72191 can effectively reduce the CSC-like population and combination with @entity900 can effectively suppress the growth of @entity189 .
