XXXX biofilm disruption using microbial surfactants.

@entity6212 @entity796 @entity3208 @entity620 @entity72579 @entity214
AIMS: To establish the ability of the rhamnolipids biosurfactants from @entity796 , in the presence and absence of @entity6212 and @entity620 , to disrupt bacterial biofilms, compared with the anionic @entity72579 surfactant @entity3208 ( @entity214 ). METHODS AND RESULTS: @entity796 ATCC 15442 biofilms were disrupted by rhamnolipids at concentrations between 0.5 and 0.4g/L and with @entity214 at 0.8g/L. The combination of rhamnolipids 0.4g/L and @entity6212 at 0.1 g/L showed a remarkable effect on biofilm disruption and cell killing. After 30 min of treatment most of the biofilm was disrupted and cell viability was significantly reduced. Neither @entity6212 nor @entity620 has any effect on biofilm disruption at 0.1g/L. @entity214 is an effective antimicrobial agent, however in the presence of @entity6212 its effect was neutralised. CONCLUSIONS: The results show that rhamnolipids at low concentration in the presence of @entity6212 are promising molecules for inhibition/disruption of biofilms formed by @entity796 ATCC 15442. SIGNIFICANCE AND IMPACT OF THE STUDY: The disruption of biofilms has major significance in many industrial and domestic cleaning applications and in medical situations. This article is protected by copyright. All rights reserved.
