Significance of multidrug resistance gene-related proteins in the postoperative chemotherapy of XXXX .

@entity1 @entity13978 @entity356 @entity5
BACKGROUND: Multidrug resistance (MDR) is a serious problem in chemotherapy and is one of the main reasons for a poor outcome of @entity356 . Study on the key proteins in multidrug resistance is necessary for the treatment of @entity356 . METHODS: The expression of ToPo II, @entity13978 and GST-   in 119 @entity356 was retrospectively examined, and the results were analyzed in correlation with clinicopathological data. ToPo II negative, @entity13978 positive and GST-   positive were regarded as three risk factors which may be associated with chemotherapy resistance and poor prognosis. @entity1 were divided into two groups: high-risk group (>= 2 risk factors) and the low-risk group (<2 risk factors), and the @entity5 recurrence and @entity1 ' survival time of the two groups were also analyzed. RESULTS: The positive rates of ToPo II, @entity13978 and GST-   were 73.9%, 42.9% and 51.3%, respectively. The positively correlation between the expression of @entity13978 and GST-   had been found. A significant correlation was shown between ToPo II expression and the level of differentiation. Significant differences with GST-   expression were also found in relation to the sex and differentiation. In the high-risk group, the 3-year survival rate of @entity1 with/without chemotherapy were 62.1% and 52.0%, 5-year survival rates were 44.8% and 40.0%, but the difference was not statistically significant (P>0.05). In the low-risk group, the 3-year survival rate of @entity1 with/without chemotherapy were 81.2% and 51.5%, 5-year survival rates were 71.9% and 45.5%, and the difference was statistically significant (P<0.05). CONCLUSIONS: Combined detection of MDR-related proteins ToPo II, @entity13978 and GST-   may be prospectively valuable for postoperative individualized chemotherapy, and further predict the outcomes of @entity356 @entity1 .
