Differential expression of @entity10483 integrins in nonneoplastic smooth and striated muscle cells and in XXXX derived from these cells.

@entity10483 @entity5 @entity1822 @entity2393 @entity1293 @entity980 @entity2909 @entity6927
Integrins are a superfamily of transmembrane alpha beta heterodimers that play an important role in cell-matrix and cell-cell interactions by acting as receptors for extracellular matrix proteins and for cell adhesion molecules. Using monoclonal antibodies against @entity10483 , @entity6927 to alpha 6, and alpha v subunits, the in situ distribution pattern of @entity2393 was examined immunohistochemically in nonneoplastic smooth and striated muscle cells and in their @entity5 . Nonneoplastic smooth muscle cells were @entity10483 +, @entity6927 +, alpha 3+, alpha v+ and, in diverse localizations, also alpha 5+ or even alpha 6+. The expression of the @entity10483 chain was conserved in all @entity2909 and @entity1822 . The distribution pattern of the alpha subunits by contrast underwent several changes during malignant transformation of smooth muscle cells. These alterations consisted in a neoexpression of alpha 2, @entity1293 , and alpha 6 as well as in an abnormal abrogation of @entity6927 3 in some @entity1822 . Except for the absence of alpha 5 in the majority of @entity1822 , expression of the alpha 5 and alpha v subunits was mainly conserved. In addition, @entity5 with epithelioid differentiation differed from typical cases by the absence of @entity6927 and the simultaneous presence of @entity1293 . Adult striated muscle cells were @entity10483 + but @entity6927 - to alpha 6- and alpha v-, whereas fetal striated muscle cells were not only @entity10483 + but also alpha 3+/-, @entity1293 +/-, alpha 5+ and alpha 6+. In all @entity980 the expression of @entity10483 was retained. Furthermore, the majority of cases showed the expression of one or more alpha subunits most of which, ie, @entity1293 , alpha 5, and alpha 6, were also found in fetal striated muscle cells. In conclusion, @entity10483 integrins exhibited a differential expression pattern along the two lines of myogenic differentiation. This integrin profile underwent characteristic changes during malignant transformation. Nevertheless, the compiled distribution patterns of the @entity6927 , alpha 3, and alpha v subunits allowed in most instances the discrimination between @entity5 of smooth ( @entity6927 +/alpha 3+/alpha v+) and striated muscle ( @entity6927 -/alpha 3-/alpha v-) differentiation.
