Glycemic Control in Type 1 XXXX and Long-Term Risk of Cardiovascular Events or Death After Coronary Artery Bypass Grafting.

@entity1 @entity64 @entity712 @entity6 @entity299 @entity583 @entity204 @entity65
BACKGROUND: @entity1 with @entity6 ( @entity6 ) have a high risk of @entity65 . OBJECTIVES: The aim of this study was to investigate whether preoperative hemoglobin A1c (HbA1c) levels could predict @entity65 or @entity204 after coronary artery bypass grafting (CABG). METHODS: This was a nationwide population-based observational cohort study that included all @entity1 with @entity6 who underwent primary isolated nonemergency CABG in Sweden between 1997 and 2012, according to the Swedish National @entity6 Register and the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in @entity299 Evaluated According to Recommended Therapies) register. We calculated the crude incidence rates and 95% confidence intervals (CIs) and used Cox regression and multivariable hazard ratios (HRs) to estimate the risk of both all-cause mortality and major adverse @entity65 (MACE), defined as @entity583 , @entity64 , @entity712 , or repeat revascularization, in relation to HbA1c  levels. RESULTS: In total, 764 @entity1 with @entity6 were included. During a median follow-up of 4.7 years, 334 (44%) @entity1 died or had MACE (incidence rate: 82 events/1,000 @entity1 -years). After multivariable adjustment, the HR (95% CI) for  @entity204 or MACE in @entity1 with HbA1c levels of 7.1% to 8.0%, 8.1% to 9.0%, 9.1% to 10.0%, and >10.0% were 1.34  (0.82 to 2.21), 1.59 (1.00 to 2.54), 1.73 (1.03 to 2.90), and 2.25 (1.29 to 3.94), respectively, compared with the  reference category. When HbA1c was used as a continuous variable, the HR for a 1% increase in HbA1c level was 1.18, and  the 95% CI was 1.06 to 1.32. CONCLUSIONS: In @entity1 with @entity6 , poor glycemic control before CABG was associated with increased long-term  risk of @entity204 or MACE. (HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery [HARTROCS]; NCT02276950).
