Endometrial cholinergic secretory responses during estrous cycle, pregnancy and after XXXX and/or @entity1420 treatment of the @entity840 .

@entity172 @entity1420 @entity840 @entity1735 @entity5402
During estrous cycle as well as during pregnancy and after treatment with @entity172 and/or @entity1420 uterine mucus secretory responses were studied as amount of @entity1735 released from everted @entity840 uteri after transmural nerve stimulation of @entity5402 administration. In estrous cycle both stimuli increased secretion by about 20% except for the late diestrus phase, when no secretory responses were seen. In pregnancy a secretory response was noted at implantation time. From mid pregnancy and onwards secretory responses of increasing magnitude were obtained. Secretory responses persisted post partum. Evidence of an adrenergic inhibitory influence on the neurogenic cholinergic responses during metestrus was noted. Both stimuli increased @entity1735 release by about 50% above resting level in uteri from animals receiving combined hormone treatment. In uteri of animals receiving @entity172 only the increase was about 20%. No definite secretory response was obtained in uteri from animals receiving @entity1420 only. It is suggested that both hormones are necessary for full cholinergic secretory response to nerve stimulation or muscarinic drugs. It is concluded that muscarinic stimulation of the endometrium results in mucus secretion during all crucial events during the reproductive cycle. Furthermore a cholinergic secretory innervation seems to be present at all these times.
