Prognostic significance of microsatellite instability determined by immunohistochemical staining of @entity4311 and @entity6756 in sporadic T3N0M0 XXXX .

@entity1 @entity6756 @entity124 @entity5 @entity4311 @entity1350 @entity3 @entity694
BACKGROUND: @entity124 ( @entity124 ) has been identified as a factor with good prognosis and @entity5 . The purpose of this study was to evaluate the routine use of immunohistochemical analysis (immunohistochemical staining of @entity4311 and @entity6756 ) to identify T3N0M0 (stage II) @entity694 with @entity124 and assess the prognostic value of this analysis. The study was conducted in a large cohort of @entity1 in a single institution who had a curatively resected T3N0M0 @entity694 and were not receiving adjuvant therapy. METHODS: Between June 1995 and December 2001, 142 @entity1 (77 females) with a mean age of 68 years, suffering from T3N0M0 @entity694 curatively resected and not receiving adjuvant therapy, were checked in terms of their follow up status. The results of colonoscopy, hepatic ultrasonography, chest x ray, and blood carcinoembryological antigen were noted. All @entity5 were immunohistochemically stained for @entity4311 and @entity6756 . Perineural invasion, @entity3 , and the presence of @entity1350 were assessed. RESULTS: Twenty four @entity1 (17%) had @entity5 . @entity1 with @entity124 and microsatellite stable (MSS) @entity5 did not differ in terms of age, @entity3 , or the presence of @entity1350 . @entity1 with @entity5 were more frequently female (18/24 v 60/118; p = 0.001) and more frequently suffered from right sided @entity5 (19/24 v 58/118; p<0.001). @entity1 with @entity5 exhibited significantly better recurrence free survival than those with @entity5 (p = 0.02). Cox analysis identified age and @entity124 determined by immunohistochemistry as independent predictive factors of good prognosis (p = 0.009, odds ratio 1.04 (1.01-1.08); p = 0.04, odds ratio 7.9 (1.05-59.6)). CONCLUSIONS: @entity124 determined by immunohistochemistry is an independent predictive factor of good prognosis in T3N0M0 @entity694 . The prognosis for @entity124 T3N0M0 @entity694 is excellent and chemotherapy should not be proposed in these @entity1 as immunohistochemical analysis produces rapid results.
