Serum XXXX Level is Higher and Related with @entity2690 in Acanthosis Nigricans-related @entity28 .

@entity1 @entity15595 @entity28 @entity6 @entity3594 @entity2690 @entity3190 @entity209 @entity413
UNASSIGNED: Objective: @entity3594 ( @entity3594 ) is proved to be a skin phenotype of @entity3190 especially in @entity28 @entity1 . @entity15595 is a new myokine which plays an important role in @entity209 , such as @entity28 , @entity2690 resistance, and type 2 @entity6 . The role of @entity15595 in the development of @entity3594 -related @entity28 is not yet understood. In this study, we aimed to investigate the relationship between @entity15595 and @entity3594 -related @entity28 . @entity1 _ Measurements: 30 @entity28 @entity1 without @entity3594 (OB group), 30 @entity28 @entity1 with @entity3594 ( @entity3594 group), and 20 age-matched healthy volunteers (control group, CON) were included in this study. Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all @entity1 . Oral @entity413 Tolerance tests (OGTT) were performed and serum @entity413 and plasma @entity2690 were measured at 0, 30, 60,120 and 180   min. The AUC (area under curve) of @entity413 and @entity2690 was calculated. Serum @entity15595 was measured by ELISA. Results: @entity3190 is found in both @entity3594 and OB groups. The @entity3594 group had higher levels of @entity2690 but better blood @entity413 tolerance and @entity2690 response. The difference in @entity15595 levels between the 3 groups was statistically significant, with the @entity3594 group showing the highest serum level of @entity15595 . Serum @entity15595 levels were positively correlated with BMI, and fasting @entity2690 . Conclusion: @entity3594 is a state of hyperinsulinmia and has better @entity2690 response and @entity413 tolerance compared to @entity28 @entity1 without @entity3594 . Serum @entity15595 may be a protective factor against impaired beta cell function in @entity28 with @entity3594 .
