[Liver lesions induced by XXXX and @entity1169 ].

@entity1169 @entity39 @entity648 @entity1448 @entity56 @entity99 @entity11848
The antihypertensive drugs @entity11848 and @entity1169 can produce identical liver injuries which must be distinguished clinically and morphologically from @entity99 . In 19 cases selected from our biopsy file during the last two years, clinical and morphological findings suggested that the @entity99 diagnosed by light microscopy had been caused by an adverse reaction to @entity11848 and/or @entity1169 . In order to establish a causal relation the lymphocyte proliferation test (LPT) was performed with @entity11848 in 11 cases. Positive results were observed in 9 cases, demonstrating an etiologic role for @entity11848 in @entity99 in these cases. The @entity11848 and/or @entity1169 induced @entity99 consisted mainly of @entity99 with confluent (bridging) @entity39 . Different findings were observed in three cases: In two of these @entity99 with @entity39 was observed together with eosinophilic cholangio-cholangiolitis. In one other case the histologic changes corresponded to drug @entity99 resembling @entity99 . Each of the three cases showed @entity1448 , a feature which is unusual in @entity99 with @entity39 irrespective of serum @entity648 levels. In one third of our cases we found morphological features of @entity56 in the liver biopsies. Considered together with the results of LPT these features emphasize the role of cell mediated immune reaction in the mechanism of @entity99 caused by @entity11848 and/or @entity1169 .
