The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in @entity2530 of the Femoral Head in XXXX .

@entity235 @entity1603 @entity39 @entity2530
This study aimed to investigate if autologous bone marrow mesenchymal stem cells (MSCs) could treat @entity2530 of the femoral head (ONFH) and what the fate and distribution of the cells are in @entity235 . Twelve @entity235 were randomly divided into two groups: MSCs group and SHAM operated group. After three weeks, @entity235 in MSCs group and SHAM operated group were intra-arterially injected with autologous MSCs and 0.9% normal saline, respectively. Eight weeks after treatment, the @entity39 volume of the femoral heads was significantly reduced in MSCs group. Moreover, the trabecular bone volume was increased and the empty lacunae rate was decreased in MSCs group. In addition, the @entity1603 -positive MSCs were unevenly distributed in femoral heads and various vital organs. But no obvious abnormalities were observed. Furthermore, most of @entity1603 -positive MSCs in @entity39 region expressed osteocalcin in MSCs group and a few expressed peroxisome proliferator-activated receptor-y (PPAR-y). Taken together, these data indicated that intra-arterially infused MSCs could migrate into the @entity39 field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads. It suggests that intra-arterial infusion of autologous MSCs might be a feasible and relatively safe method for the treatment of femoral @entity39 .
