Thoracic epidural anaesthesia decreases the incidence of @entity943 during acute myocardial ischaemia in the anaesthetized XXXX .

@entity1041 @entity4486 @entity591 @entity1341 @entity2224 @entity1540 @entity35 @entity583 @entity943
The aim of the present investigation was to study the effect of high thoracic epidural anaesthesia ( @entity1041 ) on the incidence of @entity943 after ligation of the left coronary artery in @entity4486 -anaesthetized @entity35 . Forty animals were randomly assigned to receive either 40-50 microliter of @entity1341 (5 mg/ml) or saline in implanted thoracic epidural catheters. @entity1041 decreased mean arterial pressure (MAP) from 118 +/- 5 mmHg to 72 +/- 4 mmHg and heart rate (HR) from 450 +/- 9 to 387 +/- 8 beats/min, while epidural saline did not affect MAP and HR. In both groups coronary artery ligation induced a transient decrease in MAP within the first 5-10 min after ligation. In the control group HR increased, during the 30-min post-ligation period, from 453 +/- 9 to 474 +/- 10 beats/min (P less than 0.05) while no significant change was seen in the @entity1041 group. In both groups the mortality rate was 10%. In the @entity1041 group 30% and in the control group 0% had normal sinus rhythm during the recording period (P less than 0.001). The incidence of @entity2224 and/or @entity591 was significantly lower (P less than 0.05) in the @entity1041 group (20%) compared to the control group (53%). The incidence of @entity1540 did not differ between the two groups. We conclude that @entity1041 -induced blockade of sympathetic afferents and efferents may offer protection against malignant @entity943 in the early phase of acute @entity583 .
