XXXX pathway polymorphisms and antidepressant response.

@entity1 @entity308 @entity4131 @entity42268 @entity5733 @entity6635 @entity7712 @entity750 @entity1633 @entity4149 @entity38257
INTRODUCTION: Genes that regulate the @entity5733 metabolism pathways are potential targets for research in the antidepressant treatment response. This study was intended to determine whether antidepressant responses to selective @entity750 reuptake inhibitors (SSRIs) are associated with genetic polymorphisms of the @entity4149 or @entity6635 gene in Chinese @entity308 ( @entity308 ) @entity1 . METHODS: A total of 290 @entity308 @entity1 were recruited and received a 6-week SSRIs randomized double-blinded treatment. Allele, genotype, and haplotype frequencies were compared between responders and nonresponders in @entity5733 genes. RESULTS: Genotype frequency of the @entity38257 polymorphism in the @entity4131 gene was significantly different between responders and nonresponders after false discovery rate correction (P   =   0.042). The frequency of the @entity4131 @entity38257 CG genotype was significantly higher (P   =   0.003) in responders (51.4%) than in nonresponders (35.8%), and @entity1 with the CG genotype showed an 81.7% response rate. In comparison, the response rates were 73.9% and 52.2% in @entity1 with the GG genotype and the CC genotype, respectively. The frequencies of the @entity4131 @entity38257 CC and GG genotypes were significantly lower (P   =   0.003) in responders (7.7%, 40.9%) than in the nonresponders (19.4%, 44.8%). No significant difference was found between two groups either in genotype or allele frequencies of single nucleotide polymorphisms in the TPH, @entity42268 , @entity7712 , or @entity1633 genes. No significant difference was found between two groups in TPH, @entity42268 , @entity7712 , @entity1633 , orDRD4 gene haplotypes. DISCUSSION: Polymorphisms of the @entity4131 gene appear to be associated with SSRI treatment response in Chinese @entity308 @entity1 .
