Skin Involvement of Mantle Cell Lymphoma May Mimic Primary Cutaneous Diffuse Large @entity1892 , XXXX .

@entity1 @entity588 @entity706 @entity1074 @entity13197 @entity14546 @entity20630 @entity2282 @entity4042 @entity4910 @entity1892 @entity1073
UNASSIGNED: @entity1073 ( @entity1073 ) is a @entity1892 with a variable and generally aggressive clinical course. So far our knowledge of skin involvement of @entity1073 is limited. To understand the clinical and histopathologic features of @entity1073 with skin involvement, the files of the Lymph Node Registry Kiel were screened for @entity1073 diagnosed in the skin. Over a period of 13 years, 1321 biopsy specimens were diagnosed as @entity1073 ; among them, 14 @entity1 (1%) showed skin involvement. Of these, skin was the initial site of manifestation in 6/11 (55%) cases. One @entity1 presented with a skin-limited @entity706 . Furthermore, 7/12 (58%) @entity1 presented with lesions on the leg. The @entity706 were highly proliferative with blastoid cytology in 12/14 (86%) cases. Moreover, the immunophenotype with expression of @entity588 (100%), @entity14546 / @entity20630 (83%), and IgM (82%) and lack of @entity2282 (25%) and @entity4042 (0%) closely resembled the features of primary cutaneous diffuse large @entity1892 , @entity13197 . Solely the expression of @entity4910 (100%) and the presence of t(11;14) (100%) allowed a distinction from cases of primary cutaneous diffuse large @entity1892 , @entity13197 . Only 2 @entity1073 cases with skin involvement presented with classical cytology. Interestingly, in these 2 cases skin involvement occurred simultaneously in a lesion of coexisting primary @entity1074 . Our data suggest that clinical presentation on the leg and blastoid cytology along with high proliferation and expression of @entity588 , @entity14546 / @entity20630 , and IgM are typical for @entity1073 involving the skin. Lymphomas with these features might be erroneously diagnosed as diffuse large @entity1892 , @entity13197 , if @entity4910 staining is not performed.
