Activity of @entity3524 and @entity2756 alone and in combination with penicillin, XXXX and @entity3400 against @entity693 pathogens.

@entity2756 @entity3405 @entity5125 @entity5898 @entity693 @entity3524 @entity3397 @entity3400 @entity869 @entity526
The activities of @entity3397 , @entity869 , @entity3400 , @entity3524 and @entity2756 alone and in combination against 130 isolates of @entity526 , group B streptococci and @entity5125 from @entity693 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity3524 and @entity2756 were highly active against @entity526 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity3397 was more active than @entity869 and @entity3400 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity869 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity3405 combination was synergistic for 3-14% of @entity526 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity2756 combinations were less synergistic than the @entity3524 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity526 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity3397 - @entity5898 and @entity869 - @entity5898 combinations. A significant increased killing of List. monocytogenes was observed with @entity3397 - @entity5898 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.
