XXXX activation of @entity10182 signaling prevents hyperactive @entity32 and @entity8 in a @entity19 model of @entity8 .

@entity32 @entity8 @entity10182 @entity19 @entity41733 @entity56985 @entity39939 @entity309
UNASSIGNED: @entity39939 is originally derived from medicinal herb and used preferentially in treatment of @entity309 in Far East regions. @entity56985 has strong anti-inflammatory and immune-regulatory properties, acting mainly through inhibiting NF-kB signaling. Although the upstream target through which @entity56985 affects NF-kB activity is unknown, evidence suggests that @entity56985 might regulate @entity32 through @entity10182 signaling. In this study we explored the role of @entity10182 in mediating @entity56985 's anti- @entity32 and kidney protection in a @entity19 model of @entity8 . We found that @entity56985 is an activator of @entity10182 signaling. It markedly increased @entity10182 protein level, @entity10182 nuclear translocation, Nef2 transcription capacity, and the downstream protein expression. We further demonstrated that @entity56985 activation of @entity10182 is likely due to its repression of the @entity10182 inhibitor @entity41733 since it drastically reduced @entity41733 protein through the PKC-sensitive ubiquitination-proteasomal degradation. @entity56985 treatment of @entity8 @entity19 effectively reduced the @entity8 and inflammatory responses, @entity8 , and improved the pathological protein expression in an @entity10182 dependent manner. In addition, @entity56985 also @entity10182 -dependently modulated macrophage M1/M2 polarization and inhibited the IkBa phosphorylation and NF-kB nuclear translocation, hence revealing an important upstream event that contributed to its anti- @entity32 and tissue protection. Taken together our study has identified a novel pathway through which @entity56985 exerts its anti- @entity32 and renal protective functions, and provided a molecular basis for @entity56985 potential applications in the treatment of kidney and other @entity32 .
