Correlation of lipoprotein(a) levels and myocardial stress thallium scintigraphy pattern in different entities of XXXX severity.

@entity1 @entity296 @entity2204 @entity301 @entity63 @entity1674 @entity755 @entity1188 @entity1675 @entity165
BACKGROUND: Higher levels of lipoprotein(a) confer an increased risk for @entity301 ( @entity301 ). @entity2204 genotype ( @entity2204 ) also plays a role, the @entity2204 epsilon 4 allele being associated with @entity301 . Furthermore, higher Lp(a) concentrations are correlated with @entity2204 epsilon 4 allele presence. The study was performed to investigate the relationship of Lp(a) and @entity2204 with the functional status of coronary arteries as evaluated by @entity296 . @entity1 AND METHODS: We studied 70 @entity1 (27 F and 43 M; mean age: 55 +/- 6 yrs.) consecutively referred for @entity301 , and 50 normal sex and age-matched controls. Total @entity165 , LDL- @entity165 , HDL- @entity165 , @entity1674 , @entity1675 , @entity755 , Lp(a) levels (ELISA), Lp(a) isoforms (Immuno Blotting) and @entity2204 (PCR) were measured in all subjects. Only @entity301 @entity1 underwent a myocardial tomographic stress thallium scintigraphy (201Tl-SPECT); the SPECT pattern was classified as follows: no perfusion defects (unstable angina group = 1), reversible defects at stress images ( @entity63 group = 2), fixed defects ( @entity1188 group = 3). RESULTS: Lp(a) medians were significantly higher than controls in group 1 (p < 0.05), 2 (p < 0.001) and 3 (p = 0.00). Low molecular weight isoforms (B, S1, S2) were significantly more frequent in all @entity301 - @entity1 vs. controls (p < 0.05), whereas @entity2204 genotypes did not differ among controls and @entity1 . Multiple regression analysis showed family history (p < 0.001) to be the only independent predictive variable of @entity301 severity correlated to the scintigraphic pattern. CONCLUSION: Among the considered biological parameters in our @entity1 only Lp(a) plasma levels are related to the entity of @entity63 cardiac wall damage as evaluated by 201Tl-SPECT.
