The influence of field size, treatment modality, commissure involvement and histology in the treatment of early XXXX with irradiation.

@entity1 @entity5
One hundred and thirty-seven @entity1 with TNM staged T1 glottic @entity5 were treated from 1966 to 1980. The @entity1 characteristics were no different from those noted in previous studies. @entity1 were treated either with 60Co teletherapy units or 4 MeV linear accelerators with different daily (180-225) and weekly (4 times vs. 5 times) fractionation schemes. A recurrent-free survival was attained in 80% of the @entity1 2 years after primary treatment with radiation therapy. There were 27 local recurrences, of which 82% were salvaged with surgery for an overall adjusted survival of 95%. @entity1 treated on 60Co units with field sizes less than or equal to 30 sq. cm had a 15% increase in local recurrence compared with field size greater than 30 sq. cm, which could not be attributed to lower doses. Poorly differentiated @entity5 and those involving the anterior commissure were more likely to develop a local recurrence. Doses above 1900 ret were associated with a decrease in local recurrence in @entity1 having anterior commissure involvement. Salvage with limited surgery for failure was effective in selected cases.
