Long-term peptic ulcer rebleeding risk estimation in XXXX undergoing haemodialysis: a 10-year nationwide cohort study.

@entity1 @entity1066 @entity1575 @entity454
OBJECTIVE: We aimed to study 1-, 5- and 10-year risks of peptic ulcer rebleeding among @entity454 ( @entity454 ) @entity1 with regular haemodialysis, to identify the high-risk subpopulation, and to estimate the number needed to harm (NNH) to increase a peptic ulcer rebleeding in different periods. DESIGN: A nationwide cohort study. SETTING: Data from the Taiwan National Health Insurance Research Database. @entity1 : Uraemic cohort and matched controls were selected from among hospitalised @entity1 with a primary diagnosis of peptic @entity1066 . In total, 6447 uraemic @entity1 and 25,788 age-, gender- and gastroprotective agent use-matched controls were selected. Intervention No. Main outcome measures Cumulative incidences and HRs. RESULTS: The cumulative incidences of @entity454 @entity1 were significantly higher than the cumulative incidences of matched controls (1 year: 18.8% vs 14.2%; 5 years: 38.5% vs 31.4%; and 10 years: 46.3% vs 39.4%; all p<0.001). The NNH to increase a peptic ulcer rebleeding by @entity454 at 1, 5 and 10 years were 22, 15 and 15, respectively. On multivariate analysis, @entity454 (HR=1.38, p<0.0001) was an independent risk factor for rebleeding. Compared with matched controls, @entity454 was associated with higher risk of rebleeding especially in @entity1 using ulcerogenic agents (HR=1.33-1.45), indication to prescribe gastroprotective agents (HR=1.44) and with @entity1575 (HR=1.45). CONCLUSIONS: @entity454 @entity1 had higher long-term risk of peptic ulcer rebleeding, especially in certain populations. The enhanced risk gradually decreased after the first year and stabilised after the fifth year.
