[Perioperative XXXX secretion rhyme in @entity1 undergoing coronary artery bypass grafting surgery].

@entity1 @entity2493 @entity1875 @entity701 @entity3575
OBJECTIVE: To investigate perioperative patterns of @entity2493 and @entity701 secretion rhyme in @entity1 undergoing coronary artery bypass grafting surgery. METHODS: Eleven male @entity1 scheduled for elective coronary artery bypass grafting surgery (CABG) under hypothermic cardiopulmonary bypass (CPB) were enrolled in the study. Anesthesia was induced and maintained with @entity1875 (3 mg.kg-1.h-1) and supplemented with @entity3575 (15 micrograms/kg). Blood samples were taken during surgery at specific time-points and every 3 h in the immediate postoperative period and postoperative day 2 and day 3. Plasma @entity2493 and @entity701 levels were measured by radioimmunoassay and enzyme-linked immunosorbent assay respectively. RESULTS: During surgery, plasma @entity2493 levels were below the minimum sensitivity level but low levels, without circadian variation, were measured during the immediate postoperative period. During postoperative day 2 and day 3, circadian secretion patterns of @entity2493 were present in 10 @entity1 and showed an inverse correlation with light intensity exposed (r = -0.480, P = 0.01). Plasma @entity701 levels in the immediate postoperative period were significantly higher than those before induction of anesthesia (P < 0.01). During postoperative day 2 and day 3, only 3 @entity1 regained circadian secretion of @entity701 . CONCLUSIONS: It is concluded that @entity2493 and @entity701 secretion are disrupted during cardiac surgery and in the immediate postoperative period.
