One-week and 6-month cardiovascular magnetic resonance outcome of the pharmacoinvasive strategy and primary angioplasty for the reperfusion of ST-segment elevation XXXX .

@entity1 @entity1188 @entity299 @entity583 @entity204
INTRODUCTION AND OBJECTIVES: Pharmacoinvasive strategy represents an attractive alternative to primary angioplasty. Using cardiovascular magnetic resonance imaging we compared the left ventricular outcome of the pharmacoinvasive strategy and primary angioplasty for the reperfusion of ST-segment elevation @entity583 . METHODS: Cardiovascular magnetic resonance was performed 1 week and 6 months after @entity1188 in two consecutive cohorts of @entity1 included in a prospective university hospital ST-segment elevation @entity583 registry. During the period 2004-2006, 151 @entity1 were treated with pharmacoinvasive strategy (thrombolysis followed by routine non-immediate angioplasty). During the period 2007-2008, 93 @entity1 were treated with primary angioplasty. A propensity score matched population was also evaluated. RESULTS: At 1-week cardiovascular magnetic resonance, pharmacoinvasive strategy and primary angioplasty @entity1 showed a similar extent of area at risk (29  15 vs. 29  17%, P=.9). Non-significant differences were detected by cardiovascular magnetic resonance at 1 week and at 6 months in infarct size, salvaged myocardium, microvascular obstruction, ejection fraction, end-diastolic volume index and end-systolic volume index (P>.2 in all cases). The same trend was observed in 1-to-1 propensity score matched @entity1 . The rate of major adverse @entity299 ( @entity204 and/or re- @entity1188 ) at 1 year was 6% in pharmacoinvasive strategy and 7% in primary angioplasty @entity1 (P=.7). CONCLUSIONS: A pharmacoinvasive strategy including thrombolysis and routine non-immediate angioplasty represents a widely available and logistically attractive approach that yields identical short-term and long-term cardiovascular magnetic resonance-derived left ventricular outcome compared to primary angioplasty.
