The maximum capacity of the liver of the adult dairy @entity291 to metabolize XXXX .

@entity13101 @entity1133 @entity3265 @entity6190 @entity648 @entity598 @entity880 @entity3655 @entity291 @entity413
1. Three adult dairy @entity291 were fitted with cannulas in a mesenteric, portal, hepatic and jugular vein and a carotid artery. They received infusions of step-wise increasing amounts of @entity3265 as @entity6190 via a mesenteric vein until NH 3 intoxication occurred. @entity13101 was used in control infusions. The maximum rate of uptake of @entity3655 by the liver and the concentrations of @entity413 , @entity1133 , @entity880 , @entity598 and @entity648 in blood were measured. 2. During the infusions of @entity6190 the liver extracted almost all the @entity3655 present in the portal vein until an infusion rate of approximately 15.0 mmol/min was reached. The maximum capacity of the liver to remove @entity3655 during its first pass was on average 1.84 mmol/min per kg wet weight. The @entity291 became intoxicated when arterial plasma @entity3265 concentrations reached 0.8 mmol/l. Concentrations of @entity3655 in jugular venous blood were between 66 and 74% of those in the carotid.
