Ubiquitin-positive pneumocytes and inclusion bodies are present in XXXX .

@entity1 @entity32 @entity1997 @entity2681 @entity189 @entity3616 @entity401 @entity130
OBJECTIVE: We previously reported that various types of @entity401 ( @entity401 ) patterns contain intracytoplasmic eosinophilic inclusions or Mallory bodies (inclusions) that are ubiquitin positive (Ub+). In the present study, we examined tissues with the @entity3616 pattern (OP) to determine if they contain inclusions and Ub+ pneumocytes using lobectomized specimens. METHODS: Tissues from 34 @entity1 with secondary OP, which appeared in 33 @entity189 and 1 @entity1997 , were histologically evaluated for the type of intraluminal granulation tissue and the presence of @entity2681 and inclusions. Granulation tissues were classified into polypoid, mural and occluded subtypes according to Basset's criteria and scored. RESULTS: Inclusions were noted in 5.9% of the secondary OP cases with light microscope. Ub+ pneumocytes were detected after immunostaining and all inclusions were Ub+. Ub+ pneumocytes (inclusions) were noted in 14.7% of the secondary OP cases. OP contained pneumocyte @entity2681 and @entity32 without a significant difference in the Ub+ and Ub- subgroups. Although there was no significant difference in the polypoid type of granulation tissue between the Ub+ and Ub- negative (Ub-) subgroups, the Ub+ subgroup had significant increases (p<0.05) in the mural-occluded type of granulation tissue (Ub+: 1.76  0.64, n=5 vs. Ub-: 0.72  0.87, n=29) as compared to the Ub- subgroup. CONCLUSION: Some @entity1 with secondary OP had Ub+ inclusions as @entity130 .
