Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating XXXX with @entity879 : A randomised study.

@entity1707 @entity8357 @entity3265 @entity2655 @entity879 @entity648 @entity409 @entity1578 @entity6741 @entity8688 @entity258
BACKGROUND _ AIMS: Extracorporeal blood purification systems for supportive therapy of @entity1578 are widely used. We developed a novel blood purification system, named @entity8357 's artificial liver system ( @entity8357 - @entity2655 ), which couples low-volume plasma exchange ( @entity258 ) with plasma filtration adsorption (PFA). This study aims to evaluate the efficacy of our novel system in @entity1707 with @entity879 ( @entity879 ). METHODS: Thirty-two @entity1707 were infused with @entity8688 (1.3g/kg) to induce @entity879 . All animals were equally and randomly divided into four groups: the @entity879 control group received intensive care, the PFA group underwent five hour plasma recycling filtration and adsorption purification, the @entity258 group received one hour @entity258 , and the @entity8357 - @entity2655 group underwent one hour @entity258 , followed by five hour PFA. Intervention was initiated 36hours after drug administration. The efficacy of each treatment was assessed by survival time and improvement in hematological, biochemical, and immunohistological parameters. RESULTS: @entity1707 in the Li- @entity2655 group survived longer than those in the other groups (p<0.001, @entity879 control: 60  2h; PFA group: 74  2h; @entity258 group: 75  2h; and @entity8357 - @entity2655 group: 90  3h). Liver enzyme, @entity648 , @entity6741 and blood @entity3265 levels were decreased significantly after @entity8357 - @entity2655 treatment, and increases in inflammatory cytokines were ameliorated. A higher hepatocyte regeneration index was also observed in the Li- @entity2655 group. CONCLUSION: Our novel @entity8357 - @entity2655 could expedite @entity409 and improve survival time; hence, it could be promising for treating @entity879 .
