Clinicopathologic characteristics and therapeutic outcomes of primary XXXX in central Anatolia, in Turkey.

@entity1893 @entity1 @entity344 @entity706
Primary @entity344 is a common presentation of @entity1893 . The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathologic characteristics and the therapeutic outcome of primary @entity1893 . We carried out a retrospective analysis of 74 @entity1 who were presented to our center with histopathological diagnosis of primary gastro-intestinal @entity1893 between 1990 and 2001. All @entity1 have been staged according to Lugano Staging System. For histopathological classification, International Working Formulation was applied. The treatment choice concerning the surgical or non-surgical management was decided by the initially acting physician. Treatment modalities were compared using the parameters of age, sex, histopathological results, stage, and the site of disease. Of the 74 @entity1 , 31 were female and 43 were male, with a median age of 49 years (range 15-80). The stomach was the most common primary site and was seen in 51 of 74 @entity1 (68.9%). The intermediate and high @entity706 constituted 91.9% of the all cases. In a median follow-up of 29 months (range 2-128), 20 out of 74 @entity1 died. There was a three year overall survival rate in 65.4% of all @entity1 . The three year overall survival rate was better in stage I and II1 @entity1 who were treated with surgery plus chemotherapy (+/-RT) than those treated with chemotherapy alone (93.7% vs. 55.6%, p < 0.05). The stage and presence of B symptoms affected the disease free survival and overall survival significantly, but the histopathologic grade only affected the overall survival. On the basis of these results, we suggest that surgical resection is necessary before chemotherapy in early stage (stage I and II1) @entity1 with @entity1893 because of the significant survival advantage it would bring to the @entity1 .
