Lipid peroxidation in XXXX lung microsomes.

@entity596 @entity8798 @entity840 @entity1110 @entity1234 @entity1391 @entity9050 @entity68
The effects of substances known to influence lipid peroxidation were studied in @entity840 lung microsomes by measuring the formation of @entity1234 in vitro. Incubation of lung microsomes at 37 degrees C results in lipid peroxidation which appears to be an enzymatic process but is not dependent upon @entity68 . Lipid peroxidation can be initiated non-enzymatically in lung microsomes by @entity8798 , but @entity9050 and @entity596 have very little effect on @entity1234 formation. The effects of @entity1110 on lipid peroxidation are dependent upon the concentration of @entity8798 in the incubation medium. At concentrations of @entity8798 between 0.05 mM and 1 mM, addition of @entity1110 causes an increase in lipid peroxidation over that produced by @entity8798 alone. This stimulation by @entity1110 is an enzymatic process and @entity1391 is required for the maximal effect. Addition of @entity1110 to lung microsomes in the presence of @entity596 does not increase @entity1234 formation over that produced by @entity596 alone, suggesting that @entity1110 does not influence lipid peroxidation by maintaining @entity68 in the reduced form. At concentrations of @entity8798 greater than 1 mM, @entity1110 inhibits @entity8798 -induced lipid peroxidation in normal microsomes and in microsomes in which enzymes have been inactivated with heat. This latter result suggests that the inhibition by @entity1110 is at least partially non-enzymatic. The result suggests that the inhibition by @entity1110 is at least partially non-enzymatic. The results of all of these experiments are discussed and compared with those obtained during lipid peroxidation in liver microsomes. We conclude that the processes involved in pulmonary microsomal lipid peroxidation differ significantly from those in hepatic microsomes.
