Relevance of ANCA positivity at the time of renal transplantation in XXXX .

@entity1 @entity454 @entity1333 @entity229 @entity618 @entity1140 @entity7134 @entity1011 @entity19417
BACKGROUND: Renal transplantation (RTx) is the modality of choice for @entity454 due to @entity19417 ( @entity19417 ). The significance of ANCA positivity (ANCA+) at the time of RTx on recurrent disease is controversial. METHODS: We evaluated clinical outcomes and predictors of @entity1333 in sixteen transplanted @entity19417 @entity1 who were ANCA+ at RTx at a single University Medical Center. Allograft function, @entity1333 , and predictors of @entity1333 were assessed using descriptive statistics and logistic regression analysis. RESULTS: Our cohort had a median age of 64  years, 88  % Caucasians, 63  % males, 50  % @entity7134 +. All @entity1 were in remission at the time of RTx. Twelve received induction therapy and all were on @entity618 , @entity229 and @entity1140 . The mean (SD) serum @entity1011 was 1.2 (0.3) mg/dl at 1  year and 1.8 (1.7) mg/dl at last follow up. Six developed @entity1333 at post-transplant. All relapses were treated with escalation in immunosuppression. One non-compliant @entity1 suffered graft loss while the remaining @entity1 achieved remission. In adjusted logistic regression analysis, @entity7134 ANCA+ @entity1 were two times (OR 2.19, p  =  0.71) more likely to experience a relapse compared to MPO ANCA+ @entity1 . CONCLUSIONS: This study demonstrates that @entity7134 ANCA+ @entity1 may be more likely to experience relapse post-transplant. Further investigation of the predictors of @entity1333 among @entity19417 @entity1 who are ANCA+ at the time of RTx needs to be pursued.
