Effects of XXXX virus vaccine on hepatic drug metabolism.

@entity2544 @entity137 @entity12325 @entity308 @entity683 @entity8685 @entity2934
Experimental and more limited clinical studies have suggested that @entity683 vaccination may depress the oxidative hepatic metabolism of various drugs and lead to @entity137 . The alleged mechanism is the formation of interferon and the resulting decrease in @entity12325 available for drug oxidation. Because of the clinical and basic science implications of these reports, we undertook to study the effects of @entity683 vaccine on the metabolism of three commonly used drugs: @entity8685 , @entity2544 , and @entity2934 . Our healthy male subjects were studied just before and 1 and 7 days after vaccination. As expected, @entity2934 metabolism, which proceeds by glucuronidation and not oxidation, was not altered by vaccination. Surprisingly, however, the oxidation of @entity8685 was also not depressed by the vaccine. @entity2544 oxidation, which proceeds primarily by microsomal oxidation (demethylation), was significantly decreased 1 day, but not 7 days, after vaccination. Serum alpha-interferon levels rose after vaccination for only about 8 hours, and levels of gamma-interferon rose to about 500 IU/ml at 24 hours, peaked at 72 hours, and returned to normal by 100 hours after dosing. It appeared that the higher the @entity2544 clearance before vaccination, the greater the degree of clearance @entity308 after vaccination. Thus the inhibition of drug oxidation after @entity683 vaccination is selective and each drug should be studied individually. The degree of @entity308 of @entity2544 clearance is small and transient and appears to be greater in subjects with higher prevaccination clearance.
