A Functional Polymorphism in the Promoter of @entity6957 /145 Is Associated With the Risk of @entity957 in Chinese XXXX : A Case-Control Study.

@entity6344 @entity1 @entity5 @entity984 @entity957 @entity2199 @entity72117 @entity11567 @entity6957 @entity72118 @entity72119
@entity72117 is down-regulated in @entity5 , which may serve as a @entity5 suppressor by targeting @entity984 and Ras-responsive element-binding protein ( @entity2199 ). Activated @entity984 leads to down-regulation of @entity72117 transcription in a @entity2199 -dependent manner, establishing a @entity6957 /145- @entity984 - @entity2199 feedback loop. A polymorphism @entity72118 @entity6344 in the promoter of @entity6957 /145 might influence the binding of @entity11567 . We hypothesized that the @entity6957 /145 @entity72118 and @entity984 @entity72119 may be related to the occurrence of @entity957 ( @entity957 ). In this study, we genotyped the 2 polymorphisms in 415 @entity1 with @entity957 and 504 controls using polymerase chain reaction-restriction fragment length polymorphism. The promoter activities were measured by the Dual-Luciferase Reporter Assay System. We found that the @entity72118 TC genotype was associated with an increased risk of @entity957 (adjusted odds ratio [OR]=1.37; 95% confidence interval [CI], 1.05-1.80). The significantly increased association was also observed in a dominant genetic model (adjusted OR=1.32; 95% CI, 1.01-1.72). Combined analysis showed that individuals carrying the genotypes of @entity72118 TC/CC and rs712GT/TT had a 1.47-fold increased risk of @entity957 (adjusted OR=1.47; 95% CI, 1.01-2.15). By using multifactor dimensionality reduction software method, we identified a significant interaction between the @entity6957 /145 @entity72118 and @entity984 @entity72119 . Dual-Luciferase Reporter Assay showed that the luciferase activity was significantly lower in cells transfected with the @entity72118 C allele than that of the @entity72118 T allele. These findings indicate that @entity6957 /145 @entity72118 and @entity984 @entity72119 may contribute to the etiology of @entity957 in Chinese @entity1 .
