Treatment registry in XXXX ( @entity1625 ): Multicenter observational study in Lebanon.

@entity1 @entity410 @entity1625 @entity75 @entity302 @entity1662
PURPOSE: Treatment of newly diagnosed @entity302 with a single antiepileptic drug (AED) is the favored approach for @entity410 management. This observational study aimed to assess, under daily practice conditions, remission and retention rates with the first AED prescribed as monotherapy in @entity1 newly or recently diagnosed with @entity1625 . METHODS: The @entity1625 ( @entity1625 ) study was conducted on 234 Lebanese @entity1 with newly or recently diagnosed @entity1625 , requiring treatment with an AED. Demographics, baseline focal @entity410 characteristics and results of the Clinical Global Impression (CGI) scale at the 12-month visit were reported. The primary objective of this study was to assess the percentage of @entity1 who achieved a 6-month @entity410 at the 12-month visit following treatment with a first AED administered as monotherapy. Secondary outcome variables included the calculation of the 6-month @entity410 according to the baseline @entity410 types and @entity1 retention at the 12 and 18 month visits. In addition, bivariate and multivariate analyses were conducted to identify independent predictors of 6-month @entity410 at the 12-month visit. RESULTS: The mean age of the 234 eligible @entity1 was 31.6 years and the majority were males (62%). At baseline, the most common type of focal @entity410 was focal @entity410 with @entity1662 (45%), and the most frequent topographical localization was in the temporal lobe (47%). In total, 77.6% of the @entity1 achieved a 6-month @entity410 at the 12-month visit. @entity1 with an @entity75 on neuroimaging were significantly less likely to achieve a 6-month remission compared to those with no identifiable pathological substrate. @entity1 with focal @entity410 without @entity1662 at baseline had significantly lower odds of achieving a 6-month @entity410 compared to @entity1 with a combination of @entity410 types. There was no significant association between age or gender and 6-month @entity410 . The retention rates were 95.7% and 88.5% at months 12 and 18 respectively with the great majority of @entity1 (90.7%) reporting marked improvement on the CGI scale. CONCLUSIONS: A substantial proportion of @entity1 with newly diagnosed @entity302 achieved a 6-month @entity410 following treatment with a first AED administered as monotherapy. @entity1 with an @entity75 on neuroimaging and those with focal @entity410 without @entity1662 at baseline were significantly less likely to achieve a 6-month @entity410 . This study demonstrated the feasibility of conducting long-term multicenter studies in Lebanon and will hopefully serve as an impetus to conduct randomized studies in the field of @entity302 .
