Long-term outcome of primary XXXX of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth.

@entity1 @entity4929 @entity1494 @entity5 @entity189 @entity11090
BACKGROUND: Few larger studies have evaluated the long-term outcome after a diagnosis of @entity4929 of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary @entity4929 of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study. METHODS: We evaluated 189 primary PUNLMP (177 exophytic, 12 inverted), diagnosed from January 1, 2000 to December 31, 2009, in a centralized uropathology practice. We excluded PUNLMP diagnosed after a previous or with a concurrent @entity5 . Recurrence was defined as any subsequent @entity5 , regardless of the grade. Progression was defined as any subsequent higher-grade or invasive @entity5 . Recurrence and progression were established only if documented on a subsequent biopsy. Descriptive statistical analysis was performed using Microsof Excel software package. RESULTS: The location of PUNLMP included @entity1494 (1 each). After a median follow-up of 61  months (range, 9-128 months), 20.1% @entity1 developed a recurrence. Recurrence with PUNLMP only was found in 9% of @entity1 . Subsequent low-grade @entity189 was documented in 9.5% of @entity1 . Progression to high-grade @entity189 was found in 1.6% @entity1 (1% with @entity11090 ). No @entity1 with recurrent PUNLMP or subsequent low-grade @entity189 demonstrated invasion. All @entity1 with PUNLMP exhibiting an inverted growth had no recurrence or progression on follow-up. CONCLUSION: In this study, primary PUNLMP recurred primarily either as PUNLMP or low grade @entity189 . Primary PUNLMP rarely progressed to high grade or @entity189 on long term follow-up. No recurrence or progression was documented on follow-up for PUNLMP that demonstrated exclusively inverted growth. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1332825572154074.
