Prevalence of the @entity875 XXXX polymorphism and its relationship with mammographic density.

@entity1 @entity0 @entity5 @entity875 @entity1129 @entity73005
Several studies have identified the single nucleotide polymorphism @entity875 @entity73005 as a low-penetrance risk allele for @entity0 , but its prevalence and risk association in the Brazilian population have not been determined. The goal of this study was to identify the frequency of this polymorphism in the Brazilian setting. Considering the high degree of admixture of our population, it is of fundamental importance to validate the results already reported in the literature and also to verify the relationship between this variant and @entity0 risk. A total of 750 @entity1 without @entity0 were genotyped using the TaqMan PCR assay for @entity875 @entity73005 polymorphism. Clinical information was obtained from review of the medical records and mammographic density from the images obtained using the BI-RADS System. The estimated risk of developing @entity5 was calculated according to the Gail model. The genotypic frequencies observed in this study were 4.5, 38.7, and 56.6%, respectively, for the @entity875 @entity73005 AA, @entity1129 and TT genotypes. The @entity1129 and AA genotypes were encountered significantly more often in premenopausal @entity1 with moderately dense, dense and heterogeneously dense breast tissue (P = 0.023). In addition, the presence of the TT genotype was significantly associated with age at menarche >= 12 years (P = 0.023). High mammographic density, associated with @entity0 risk, was encountered more frequently in premenopausal @entity1 with the risk genotypes @entity875 @entity73005 AA and @entity1129 . The genotypic frequencies observed in our Brazilian sample were similar to those described in other predominantly European populations.
