The future for treatment by bone marrow transplantation for adrenoleukodystrophy, @entity8431 , XXXX and @entity12751 .

@entity1 @entity66 @entity73 @entity8431 @entity8019 @entity12751 @entity15224
Within the past decade, bone marrow transplantation has been applied to over 200 @entity1 worldwide with the intention of treating @entity66 . Bone marrow transplantation has provided a method for treatment of @entity8019 , @entity8431 , @entity15224 and @entity12751 . After engraftment, significant improvement in the clinical course of each of these diseases occurs. Survival data of engrafted @entity1 are superior to those of non-transplanted. Engraftment and the resulting enzymatic reconstitution are concordant. Outcomes based on neuropsychological tests indicate continued maintenance and in some cases @entity73 . Magnetic resonance imaging as well as spectroscopic examinations of the brain provide further evidence that positive changes occur in the central nervous system following long-term engraftment. A better quality of life follows engraftment. Greater gains from use of bone marrow transplantation for these particular @entity66 will occur in the future. Earlier diagnosis will allow bone marrow transplantation in the presymptomatic stage at a younger age, providing an enhancement of positive effects noted from such treatment. At the same time, advances in bone marrow technology will serve to reduce the risk factors involved with the bone marrow transplantation process itself. These two factors taken together will be more than additive in providing benefits from use of bone marrow transplantation.
