Low field strength magnetic resonance imaging of bone marrow in XXXX .

@entity1 @entity1778 @entity417
The accuracy of low field strength (0.08 Tesla) magnetic resonance imaging (MRI) of bone marrow for the detection of @entity1778 in adults has been assessed by comparison with bone marrow biopsy results. Spin lattice relaxation time (T1) measurements from @entity1 were compared with those from 90 volunteers. Eighteen @entity1 were studied at the time of diagnosis of @entity1778 . Bone marrow T1 was prolonged in all cases. One of two @entity1 with @entity417 in transformation (RAEBt) had prolonged bone marrow T1, the other had normal T1. T1 at the time of diagnosis for @entity1 with @entity1778 or RAEBt correlated with the cellularity and blast cell count in the marrow. None of the 17 @entity1 who were studied when in long-term remission of @entity1778 had prolonged marrow T1. Serial studies were undertaken in five of the newly diagnosed @entity1 . An increase in bone marrow T1 was observed in each of four @entity1 studied seven days after the start of treatment, at a time when they showed a decrease in leukaemic cells on peripheral blood examination. T1 measurements made 3 weeks after the commencement of chemotherapy were similar to pretreatment values and did not reflect the reduction in leukaemic infiltration observed on bone marrow needle aspirate. The implications and possible explanations for these findings are discussed.
