Diagnostic value of quantitative XXXX predictors with coronary CT angiography compared to invasive fractional flow reserve.

@entity1 @entity63 @entity3979 @entity8431 @entity850
OBJECTIVE: To evaluate the diagnostic performance of CCTA-derived @entity850 predictors including CT-FFR for the detection of @entity63 -inducing @entity850 compared to invasive FFR. MATERIALS AND METHODS: Stenosis parameters were assessed using dual-source CT (DSCT). All @entity1 underwent both CCTA and invasive FFR within 3 months and were retrospectively analyzed. Observers visually assessed all CCTA studies and performed multiple lesion measurements. Lesion length/minimal luminal diameter(4) (LL/ @entity8431 (4)), transluminal attenuation gradient (TAG), corrected coronary attenuation (CCO) and CT-FFR were calculated. RESULTS: The cohort included 32 @entity1 (58  12 years, 66%male). Among 32 coronary lesions, 8 (25%) were considered hemodynamically significant with an FFR <0.80. Compared to invasive FFR, the per-vessel sensitivity and specificity of CCTA, CT-FFR, LL/ @entity8431 (4), CCO and TAG for detecting hemodynamically significant lesions were 100% and 54%, 100% and 91%, 85% and 92%, 66% and 88%, 37% and 58%, respectively. Receiver operating characteristics analysis resulted in an area under the curve of 0.91 for CT-FFR (p=0.0005), 0.88 for LL/ @entity8431 (4) (p<0.0001), 0.85 for CCO (p<0.0001). TAG with an AUC of 0.67 (p=0.152) was unable to discriminate between vessels with or without hemodynamically significant lesions. CONCLUSION: CT-FFR, LL/ @entity8431 (4) and CCO provide enhanced diagnostic performance over CCTA analysis alone for discrimination of hemodynamically significant @entity3979 .
