Combined @entity1732 and irradiation in preoperative treatment of advanced XXXX .

@entity1 @entity137 @entity66 @entity957 @entity189 @entity1732 @entity204
Forty-two @entity1 with advanced @entity957 were treated with a combination regimen of @entity1732 180 mg and external irradiation 30-45 Gy. Twenty @entity1 had primary lesions, and 22 @entity1 had recurrent disease. Fifteen (75%) of the @entity1 with @entity66 showed objective response (five complete and ten partial response). Four underwent surgery. Of these, one is alive after 60 months with no evidence of disease. Two have died of unrelated causes without signs of recurrence. Seventeen relapsed and died of @entity189 . Median survival for @entity1 treated for @entity66 was 8.0 months. Thirteen (59%) of 22 @entity1 treated for recurrence showed objective response (two complete and eleven partial responses). None underwent surgery. All these @entity1 died of @entity189 . Median survival was 6.4 months. @entity137 was acceptable, and there were no treatment-related @entity204 . Even taking into account that our @entity1 had very advanced disease, the results are disappointing. An increase of the radiation dose beyond the maximum of 45 Gy given, and more aggressive surgery, might have improved the results.
