Can XXXX really prevent airway stenosis?

@entity39 @entity1138 @entity95 @entity1139 @entity5142 @entity446 @entity1224
BACKGROUND/OBJECTIVES: @entity1138 ( @entity1139 ) is used in the prevention of @entity1224 . However, the efficacy of @entity1139 is still debatable, and the potential complications of @entity1139 use have been scarcely reported. We evaluated the efficacy and early complications of @entity1139 in a wound model of the subglottis. STUDY DESIGN: A randomized animal study. METHODS: Sixty @entity95 underwent a full-thickness injury to the posterior subglottis by diode laser. The animals were randomly assigned to three groups according to the different topical treatments of @entity1139 0.4 or 10 mg/mL or saline alone for 5 minutes. Animals were killed at 4 weeks, and gross and histologic findings were compared among different groups and 10 age-matched, non-wound, normal controls. RESULTS: Thirty-two of the 60 (53%) animals died mainly of acute @entity1224 by @entity39 , sloughs on, or cartilage collapse of the unhealed posterior subglottis during early weeks after wounding, higher in the @entity1139 -treated animals (67%) than in the wound controls (25%) (P = .007). This resulted from the significant delay of wound @entity446 in the @entity1139 -treated groups compared with the wound controls (P = .012). The degree of @entity5142 was comparable among different groups (P > .8), although collagen deposition was significantly lower in the @entity1139 -treated groups compared with the untreated controls (P = .036). CONCLUSIONS: There was a significant risk of acute @entity1224 from delayed wound @entity446 in @entity95 that received subglottic laser wounding and @entity1139 treatment. This risk should be considered in the use of @entity1139 in clinical practice.
