Effects of anesthesia on carotid sinus reflex control of arterial hemodynamics in the XXXX .

@entity235 @entity4485 @entity1508 @entity4486
The detailed characteristics of the carotid sinus reflex control of regional pressure-flow relations were compared in @entity235 anesthetized with @entity4486 , @entity4485 , or @entity1508 . The carotid sinuses were isolated and perfused under conditions of controlled pulsatile pressure. Pressure and flow were measured in the ascending aorta and the celiac, mesenteric, renal, and iliac artery. Mean arterial pressure and peripheral resistance were highest under @entity4486 and lowest under @entity1508 . For cardiac output this relation was reversed. Set point values of reflex gain and overall range of control were similar under @entity4486 and @entity1508 and lowest under @entity4485 . These results were found both before and after bilateral cervical vagotomy. Operating point values of regional resistance were generally largest with @entity4486 and smallest with @entity1508 . Operating point sensitivities of regional resistances were generally smallest under @entity4485 and similar under @entity4486 and @entity1508 . Vagotomy was associated with increases in set point values of mean arterial pressure, set point gain, and overall range of control under all three anesthetics. With @entity4486 as a reference, @entity1508 does not depress cardiovascular reflex mechanisms. Carotid sinus reflexes under @entity1508 were as sensitive and well maintained as they were under @entity4486 . These reflexes were significantly depressed under @entity4485 compared with @entity4486 .
