Comparison of two @entity396 regimens for mid-trimester pregnancy terminations after FIGO's XXXX dosage recommendation in 2012.

@entity1 @entity2102 @entity396
OBJECTIVE: To compare the safety and efficacy of two @entity396 regimens for mid-trimester pregnancy terminations. METHODS: Retrospective analysis of 263 cases of pregnancy terminations with @entity396 between 12 and 24 weeks was performed. Group 1 (total 129 @entity1 ) consisted of @entity1 who were given 200   mcg vaginal @entity396 every 4   h until the abortion, whereas Group 2 @entity1 (total 134 @entity1 ) were given @entity396 as in International Federation of Gynecology and Obstetrics's (FIGO) 2012 recommendation. In case of a previous cesarean section doses were halved in both groups. Primary outcomes of the study were the time to abortion and the total drug dose used. Secondary outcome was the rate of complications. RESULTS: Total dose and time to abortion did not differ between the groups. As for complications, one @entity1 (%0.8) in group 1 developed @entity2102 and had hysterotomy. One @entity1 (%0.8) in group 2 had uterine rupture and had total hysterectomy. Two @entity1 in both groups considered failure of induction and terminated with surgery (hysterotomy). Groups did not show difference in induction failure rates. CONCLUSIONS: We respect the presence of dose recommendation stated by the FIGO and found similar results with our recent protocol. Other @entity396 regimens used worldwide should also be compared with this guideline in order to improve its efficacy.
