Inhibition of cold @entity110 by XXXX .

@entity1 @entity2402 @entity110 @entity14295
INTRODUCTION: The effect of 5 mg @entity14295 for 4 days was tested with ice-cubes before and after 4 days of treatment in 12 @entity1 with cold @entity110 . They had been asked not to take any antihistamine for at least 4 days. OBJECTIVE: To find the effect of @entity14295 on wheals and itching induced by cold. METHOD: Ice-cubes in a thin plastic foil were placed on the inside of forearms for 0.5 to12 minutes. The time needed to produce a confluent @entity110 , four or more small wheals and fewer than four small wheals were registered, together with the degree of itching. RESULTS: Before treatment a mean of 6.2 minutes was needed to cause a confluent @entity110 , and itching occurred in seven of the @entity1 . Four or more small wheals were observed after a mean of 3.7 minutes and fewer than four after a mean of 1.2 minutes. One 5 mg tablet of @entity14295 was then given each morning for 4 days and the ice-cube test was repeated 4-5 hours after the last dose: no confluent @entity110 and no itching occurred in any of the @entity1 . Four or more small wheals were seen in two @entity1 after 12 minutes, but there was no such reaction in the other 10 @entity1 ; in seven @entity1 one to three small wheals developed. After 2-3 months of continued treatment four @entity1 had noticed some wheals when out in the cold, but no itching. The symptoms of one @entity1 with a delayed reaction after exposure to @entity2402 totally after a dose increase to 10 mg. CONCLUSION: @entity14295 markedly inhibited the reactions to cold induced @entity110 .
