Chemoprevention of chemical-induced @entity1489 by XXXX root extract.

@entity1 @entity3653 @entity5 @entity1489 @entity19 @entity620 @entity1324 @entity2041 @entity224 @entity9052 @entity105
BACKGROUND: @entity5 has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing @entity5 burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the @entity5 incidence. @entity9052 is known for its potential to treat various ailments in @entity1 beings. The present study was designed to explore the anticancer and antioxidative potential of @entity9052 against chemical-induced @entity105 in mammals. METHODS: @entity1489 were induced in Swiss albino @entity19 by a single topical application of @entity3653 (100   g/100   L @entity1324 ) and, 2  wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% @entity1324 ) till the end of the experiment (i.e., 16  wk). Hydroalcoholic @entity9052 root extract at a dose of 25  mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri-post-initiation stages. RESULTS: @entity9052 root extract treatment caused a significant reduction in @entity5 incidence, cumulative number of @entity5 , @entity5 yield, and @entity5 burden, as compared to the @entity3653 -croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of @entity2041 , @entity224 dismutase, catalase, @entity620 , and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with @entity9052 root extract treatment, as compared to carcinogen-treated control group. CONCLUSION: These results suggest that @entity9052 has the potential to become a pivotal chemopreventive agent that can reduce @entity5 in mammals.
