Dysregulation of Claudin family genes in XXXX in a Chinese population.

@entity1 @entity17291 @entity5 @entity3670 @entity17290 @entity14187 @entity14 @entity3
Claudins play an important role in tumor @entity3 and in invasiveness of @entity14 ( @entity14 ). We have evaluated the relationship between @entity14 and expression of the claudin genes in Chinese @entity1 with @entity14 . We measured @entity3670 and @entity17291 mRNA using quantitative PCR, and protein levels with immunohistochemistry in @entity5 tissues and adjacent normal tissue. @entity5 tissues had significantly higher levels of @entity3670 , and significantly lower levels of @entity14187 , @entity17290 , and @entity17291 than did normal tissue. @entity14187 , @entity17290 , and @entity17291 expression levels were higher in @entity14 of the protruded type than in @entity14 of the infiltrative type. Expression of @entity17291 correlated with lymph node @entity3 . Stage N0 @entity5 tissues had higher levels of @entity17291 than did stages N1 and N2, suggesting that @entity17291 expression was closely related to the extent of lymph node @entity3 . @entity3670 protein was upregulated, but @entity17291 protein was downregulated in @entity5 tissues when compared with expression in adjacent normal tissues. In conclusion, @entity14187 , @entity17290 , and @entity17291 were significantly downregulated, whereas @entity3670 was significantly upregulated in @entity14 . The altered expression of claudin genes may play a role in the initiation and development of @entity14 .
