Biliary, fecal and plasma @entity6743 in @entity95 , hamster, @entity840 , and @entity35 : comparative study and implication in XXXX .

@entity1 @entity840 @entity95 @entity6741 @entity14 @entity35 @entity3645 @entity694 @entity6743 @entity2513
@entity3645 are believed to play a role in the etiology of @entity14 , and high fecal excretion of secondary @entity3645 was correlated with increased incidence of @entity694 . Recently, it was also reported that there is an increase in plasma of the secondary @entity6741 , @entity6743 in @entity1 with @entity2513 . Since @entity6743 is formed in the colon and absorbed into the portal systemic circulation, it was suggested that the blood concentration of this @entity6741 reflects the level of exposure of colonic cells to @entity6743 . The objective of this study was to investigate whether plasma @entity6743 level represents the fecal content of this @entity6741 in several animal species with different @entity6741 composition and @entity6743 contribution to the @entity6741 pool. Eight @entity95 , hamsters, @entity840 , and @entity35 were used in this study. Blood samples and feces were collected on days 1, 3, 5 and 7. Bile samples were obtained only on day 7. The plasma, fecal and biliary @entity3645 were analyzed by gas chromatography-mass spectrometry. @entity6741 composition and @entity6743 content varied greatly between the animal species studied. There was a variation in the concentration of total @entity3645 in the plasma and feces obtained at different times during the experiments, however, the @entity3645 profile remained constant throughout the study. The data obtained shows that although plasma @entity6741 profile was not similar to fecal @entity3645 profile, however, there was a significant correlation between the level of plasma and fecal @entity6743 . Plasma @entity6743 concentration might be a reliable biomarker for the degree of exposure of colon cells to this @entity6741 , and may be useful in further studies on the role of secondary @entity3645 in @entity694 .
