Expression of the cell adhesion molecule @entity1759 in XXXX .

@entity1 @entity10189 @entity5 @entity406 @entity189 @entity1759 @entity982 @entity3621 @entity420 @entity356 @entity1141
@entity1759 , an integral membrane glycoprotein expressed by many cell types, serves as the principal transmembrane hyaluronate receptor and may be a determinant of metastatic and invasive behavior in @entity189 . The expression of @entity1759 in 23 @entity356 and 12 @entity10189 ( @entity10189 ) resection specimens and @entity356 cell lines HS746t and KATO III was examined by immunohistochemistry using the murine monoclonal antibody A3D8 on @entity406 -fixed, @entity982 -embedded tissue or cells. Western blot analysis of whole cell lysates of KATO III and @entity1 cells showed protein bands at 85 to 90 kd with KATO III cells expressing an additional band at 145 kd. In normal stomach gastric epithelium was negative. In @entity10189 foveolar epithelium was focally positive, but staining did not correlate with the extent of @entity3621 . In @entity189 cases intensity of staining was progressively stronger comparing intestinal metaplasia with @entity1141 with @entity189 . @entity189 was invariably more strongly positive than @entity1141 or @entity189 . Twelve @entity420 were weakly positive and 11 were strongly positive. The staining intensity of metastases (12 cases) was the same or weaker than the primary @entity5 . For the 12 @entity1 whose @entity189 were weakly positive, mean length of survival for the six who died was 23.3 months. Five of the 11 @entity1 whose @entity189 strongly expressed @entity1759 died within the study period with a mean length of survival of 11.0 months. A key consequence of @entity1759 overexpression in @entity356 may be development of the invasive phenotype and strong expression may indicate a poorer prognosis.
