Expression of angiogenic and fibrogenic factors in proliferative XXXX .

@entity1 @entity6 @entity989 @entity2280 @entity12020
PURPOSE: To investigate the expression of @entity12020 ( @entity12020 ) in the retina of @entity1 subjects with @entity6 , and @entity12020 , CD105, and gelatinase B in proliferative @entity6 (PVR) epiretinal membranes. METHODS: Twelve donor eyes from six subjects with @entity6 , 10 eyes from five nondiabetic subjects, 14 PDR membranes, and five PVR membranes were studied by immunohistochemical techniques. In situ zymography was used to examine gelatinolytic activity in four PDR membranes. RESULTS: In nondiabetic retinas, there was no immunoreactivity for @entity12020 . @entity6 showed immunoreactivity for @entity12020 in ganglion cells and microglia. Vascular endothelial cells in PDR membranes expressed @entity12020 , CD105, and gelatinase B in 10 (71.4%), 11 (78.6%), and 5 (35.7%) membranes, respectively. Myofibroblasts in PDR membranes expressed @entity12020 , and gelatinase B in 14 (100%), and 6 (42.9%) membranes, respectively. There was a significant correlation between the number of blood vessels expressing the panendothelial marker @entity2280 and the number of blood vessels expressing @entity12020 (r = 0.7884; P = 0.0008), and CD105 (r = 0.6901; P = 0.0063), and the number of myofibroblasts expressing @entity12020 (r = 0.5922; P = 0.0257). There was a significant correlation between the number of myofibroblasts expressing alpha-smooth muscle actin and the number of myofibroblasts expressing @entity12020 (r = 0.8393; P = 0.0002). In situ zymography showed the presence of gelatinolytic activity in vascular endothelial cells in PDR membranes. Myofibroblasts in PVR membranes expressed @entity12020 , and gelatinase B. CONCLUSIONS: These results suggest a possible role of @entity12020 , CD105, and gelatinase B in the pathogenesis of proliferative @entity989 .
