Resistance to telomerase inhibition by @entity1 XXXX cell lines.

@entity1 @entity5 @entity957 @entity6661 @entity549 @entity3207 @entity2215
Telomeres are nucleoprotein structures at the ends of chromosomes that are composed of a repetitive G rich sequence and telomeric binding proteins. Telomeres prevent the degradation of chromosomal ends and protect against inappropriate recombination. Telomere @entity6661 involves a @entity5 suppressor pathway that limits the replication of premalignant cells. The loss of telomeric DNA with each round of replication leads to growth arrest accompanied by senescence or apoptosis. Many @entity5 cells activate the telomerase gene to bypass senescence. Telomerase is a multisubunit ribonucleoprotein that uses an RNA template to catalyze the addition of telomeric DNA to chromosomal ends. Overexpression of the @entity2215 subunit leads to telomere lengthening and extension of the replicative lifespan. @entity549 has been shown to inhibit telomerase activity in many @entity5 cell lines, and this is associated with @entity3207 and apoptosis. Additionally, pharmacological telomerase inhibitors have been developed which lead to progressive @entity3207 and programmed cell death. In this study, we report a series of @entity1 @entity957 cell lines that have high telomerase activity and short telomeres. @entity549 expression and pharmacological telomerase inhibition failed to completely inhibit enzymatic activity which was accompanied by the lack of @entity3207 . These cells continued to proliferate and demonstrated fewer responsive genes when treated with a pharmacological telomerase inhibitor. We concluded that some @entity1 @entity957 cell lines are resistant to telomerase inhibition.
