Biologic predictors of survival in node-negative XXXX .

@entity1 @entity5 @entity356 @entity3
OBJECTIVE: To evaluate factors predictive of survival following curative resection for node-negative @entity356 . SUMMARY BACKGROUND DATA: Presence or absence of lymph node @entity3 is the most powerful predictor of survival following curative resection for @entity356 . Factors predictive of survival in node-negative @entity356 have not been clarified. METHODS: Histopathology and clinical outcome for all @entity1 undergoing R0 resections for @entity356 at a tertiary center between 1985 and 2001 were reviewed. RESULTS: Of 1,256 R0 resections performed, 507 (40%) were node-negative, 465 were T1-T3, and 317 of these were adequately staged, as defined by histologic evaluation of at least 15 lymph nodes. Median age was 67 years, and 62% were male. Forty percent had T1 @entity5 , 34% were T2, and 26% were T3. Median @entity5 size was 3 cm. Vascular invasion (VI) was present in 17% of @entity5 and @entity3 ( @entity3 ) in 31%. Extended (D2) lymphadenectomy was performed in 75% of cases. Five- and 10-year disease-specific survival rates were 79% and 67% respectively. Factors associated with poorer disease-specific survival on univariate analysis were male gender, serosal invasion, presence of VI, presence of @entity3 , and resection other than distal subtotal gastrectomy. On multivariate analysis, @entity3 was not an independent predictor of survival, but correlated directly with advancing T stage and @entity5 size. CONCLUSIONS: Serosal invasion and presence of VI are strong predictors of poor survival in this disease. @entity3 correlates with T stage and @entity5 size and may serve as a marker of advanced disease.
