Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation in XXXX : Analysis of Prognostic Factors.

@entity1 @entity129 @entity410 @entity16 @entity9909 @entity400 @entity2132 @entity10 @entity2359
UNASSIGNED: @entity16 are serious complications after hematopoietic stem cell transplantation (HSCT) and significantly contribute to morbidity and mortality. The purpose of this study was to investigate the clinical features and prognosis in pediatric @entity1 who had @entity16 after allogeneic HSCT. We retrospectively reviewed the medical records of @entity1 and adolescents (19 years old or younger) who underwent allogeneic HSCT at our institution from 2000 to 2012. A total of 383 @entity1 underwent 430 allogeneic transplantations. Among them, 73 episodes of @entity16 occurred in 70 @entity1 . The cumulative incidence of @entity16 at day 400 was 20.0%. Almost two thirds of the episodes (63.0%, 46 of 73) occurred within 100 days after transplantation. @entity9909 -related @entity2359 was observed as the most common cause of @entity2359 (47.9%, 35 of 73) and was significantly associated with earlier onset @entity16 , @entity410 , and @entity400 . It also showed a significant association with lower probability of @entity10 , @entity129 , and neurologic sequelae. In a multivariate analysis, days to neutrophil engraftment after HSCT, extensive @entity2132 ( @entity2132 ) and the existence of neurologic sequelae were identified as risk factors for mortality in @entity1 who had @entity16 (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.02 to 1.15; P  = .011; HR, 5.98; 95% CI, 1.71 to 20.90; P  = .005; and HR, 4.37; 95% CI, 1.12 to 17.05; P  = .034, respectively). However, there was no significant difference in the 5-year overall survival between the @entity1 who had @entity16 without sequelae and the @entity1 who did not have any @entity16 (57.3% versus 61.8%, P  = .906). In conclusion, we found that the major significant risk factors for mortality in pediatric recipients with @entity16 were the existence of neurologic sequelae and extensive @entity2132 .
