INTRODUCTION: Coronavirus is an emerging virus that has caused many casualties. Therefore, the purpose of this descriptive study is to investigate the epidemiological situation of coronavirus in Khomein city in the province of Markazi in Iran. METHOD: This cross-sectional descriptive study was performed on all people with coronavirus disease from the first date of admission of positive PCR of patients with coronavirus until 21 September 2020. Information on the records of definitively discharged and deceased patients due to coronavirus (having positive PCR) was extracted from 20/2/2020 to 21/9/2020 and demographic characteristics such as age, gender, area of residence, occupation, and past medical history were assessed for each patient with coronavirus disease. RESULTS: The range of age of this study was from 2 months to 95 years old and their mean age was 52.9+/-19.2 years old. The mean age of men and women in this study was 52.36 and 53.84 years old, respectively, which showed no significant relationship (T=0.966, N=691, P-Value=0.335, df=689). 52.1% of deaths were in rural areas and 47.9% were in urban areas. CONCLUSION: With observing the protocols by the people as well as traffic restrictions and social distance, we gradually experienced a decreasing trend in positive coronavirus cases and hospitalization cases. Then, due to the decrease in people's sensitivity and false confidence, the second outbreak of the disease began again and reached its peak in May and July.