Coronavirus disease 2019 (COVID-19) has led to a global pandemic with nearly 158 million cases worldwide and 3.3 million deaths. Due to its easy transmissibility and high virulence, it has caused an overwhelming number of infections leading to a near-collapse of the healthcare infrastructure in some countries. In this review, we will focus on cases of Severe COVID-19 requiring mechanical ventilation, as well as advanced rescue therapy in the form of extracorporeal membrane oxygenation (ECMO).