Presently, the developments of COVID-19 situation in different countries and regions have clearly differentiated. Due to differences in resources, infrastructure, and awareness of epidemic prevention and control, capabilities for COVID-19 prevention and control in various regions have also shown a significant imbalance as the COVID-19 epidemic is entering a new normal. The objectives of this study are to provide dynamically adjusted strategies in response to developments in the COVID-19 pandemic as a new normal. In the face of the new normal, one key is normalizing epidemic prevention and control. As part of this, we should implement precise policies based on the dynamics of the COVID-19 epidemic and particular response needs. In ongoing COVID-19 prevention and control, we must pay attention to new vulnerabilities and new features in the dynamics of the epidemic. In this study, health and government officials can benefit from insights of preparing ourselves for long-term challenges and both certainties and uncertainties in a future facing COVID-19.