Accumulating evidence exists that COVID-19 vaccines might induce or exacerbate autoimmune rheumatic diseases. Currently available COVID-19 vaccines include messenger-RNA (mRNA) and recombinant adenoviral (AdV) vector vaccines, both encoding SARS-CoV-2 spike protein production as the primary target for neutralizing antibodies. We herein report a case of subacute cutaneous lupus erythematosus (SCLE) following mRNA vaccination with BNT162b2, and summarize the current literature on cutaneous lupus erythematosus occurring after COVID-19 vaccination.