A body mass index of >/=30 (>27 in those of Asian descent) kilograms per square meter constitutes the definition of obesity.[1] Obesity involves a complex interplay of genetic, sociocultural, environmental, and behavioral factors. In 1997, the World Health Organization (WHO) declared obesity a major global health issue along with undernutrition and climate change-the triad being termed "the Global Syndemic."[2] Today in the United States of America (USA), one-third of the adult population is obese, with the Center for Disease Control projecting that by 2050 60% of men and 40% of women in the USA will be obese.[3] Obesity once again came into focus during the SARS-CoV-2 pandemic, when patients with obesity were found to have an increased need for mechanical ventilation and higher mortality.[4] Once thought to be an exclusive problem of the developed world, numerous studies have shown developing countries now have the highest incidence of obesity. South-East Asians have a higher percentage of body fat, truncal/central obesity, and insulin resistance than their White race counterparts prompting the WHO to endorse a lower cut-off point for action against obesity at >/=27kg/m^2 in the Asian population.[5] The latest terminology introduced for obesity is ABCD-adiposity based chronic disease, which shifts the focus to the chronic nature of obesity and its comorbidities, which require treatment in addition to the treatment of obesity itself.[6] It is well known that obesity is associated with a shortened life span and increased incidence of obstructive sleep apnea, osteoarthritis, gout, polycystic ovarian syndrome, metabolic syndrome, prediabetes, hypertension, stroke, non-alcoholic fatty liver disease, heart failure, and cancers of the colon, breast, endometrium, and gallbladder.[7] Thus the treatment of obesity is essential, along with early identification of complications. Although this article focuses on non-dieting approaches to treating obesity with medications, gastrointestinal devices, and bariatric surgery, it must be emphasized that diet and exercise are essential to good cardiometabolic health in obese patients.