INTRODUCTION: Tick-borne encephalitis (TBE) is endemic in many parts of Eurasia including countries previously considered to be free from the disease. The incidence of TBE is changing owing to various ecological and climatic factors. The factors influencing the variability of the number of TBE cases are still under investigation. In 2020 the new coronavirus SARS-CoV-2 emerged causing COVID-19 pandemic. Governments have reorganized health care systems to contain a surge of COVID-19 cases and avoid hospital overload. Moreover, new measures have modified several aspects of social habits leading to a change in the incidence of numerous diseases. We aimed to evaluate the epidemiology of TBE in the last decade (2010-2019) and to demonstrate the impact of the surge of SARS-CoV-2 infections on the TBE incidence as reported to a national surveillance database. MATERIAL AND METHODS: We performed the analysis of the TBE notification from the epidemiologic reports in the years 2010-2019 and in the pandemic year 2020 at a national and regional level in Poland. We included data from two infectious disease departments located in the most TBE-prevalent province of Poland. RESULTS: Most cases of TBE occur in two provinces of Northeastern Poland from May to December. The increasing temporal trend occurred in Poland in 2016-2017. The increased number of cases of COVID-19 coincided with a reduction of the number of the reported TBE cases in 2020. CONCLUSIONS: Tick-borne encephalitis virus activity in Poland is invariably concentrated in endemic regions of Northeastern Poland fluctuating considerably from year to year. The decrease of TBE incidence with surge of COVID-19 patients conceivably resulted from underreporting due to limited access to specialized diagnostics. In endemic areas, TBE should be included in the differential diagnostics in all the cases when the central nervous system infection in suspected.