Analysing data from a nationally representative sample of 3442 interviews conducted in Egypt in 2020, this study examines the influence of four sets of factors in predicting compliance with the advice of healthcare professionals to combat the spread of COVID-19: demographics, knowledge and values, fear of the disease and denial, and the pandemic as a foreign invasion. The findings show that a higher likelihood of compliance is linked to socioeconomic status, awareness of the pandemic, reliance on a plurality of information sources, adherence to liberal values, and fear of the disease, but being male, young, employed, religious, fatalistic, and in denial of the severity of the pandemic lower this likelihood - all consistent with the results reported in the literature. In addition, this study highlights the link between compliance and such attributes of nationalism as national identity, national pride, the perception of the pandemic as a national event, and the willingness to sacrifice one's human right to combat the spread of the disease. Drawing on these factors, this paper suggests building societal consensus around the theme of national unity against the microparasitic invasion is the key to an effective strategy to combat the spread of the virus.