High-consequence events are not new to the daily operations and functions of security and business continuity leaders. However, the incidence of epidemics and pandemics over the past decade has changed the way organisations must be able to respond. For example, as seen with the recent COVID-19 pandemic, the forced closure of business functions and the move to remote operations creates additional challenges for leadership. This paper discusses how leadership must be prepared to react quickly and efficiently in response to the recommendations from government and recognised health organisations, while also being proactive in recognising and understanding the epidemic/pandemic, its symptoms, and the physical and emotional effects on personnel. Leadership must also understand the importance of staying connected, and be proactive when the workplace changes its physical setting. This paper will also address the issues and implications related to the return to pre-event operations, as well as preparations for the next high-consequence event.