Rationale: The knowledge about the presenting characteristics, comorbidity, and outcomes of Indian patients for COVID-19 is limited. Objective: To describe the clinical characteristics and outcomes of COVID-19 patients in Central India and to evaluate risk factors leading to requirement of oxygen, mechanical ventilation and mortality. Design, Setting, and Participants: In this retrospective, we included 365 RT-PCR confirmed cases of 2019-nCoV in Sri Aurobindo Medical College and PG Institute, Indore, Madhya Pradesh from March 25, 2020 to May 15, 2020. Results: A total of 365 patients - 329 adults (Median age 49 years, 58.66% males) and 36 pediatric patients (Median age 10.5 years) were included. There was presence of comorbidity in 47.11% adults with most common being hypertension (24.92%), and diabetes (25.18%). 45.28% of adult patients were asymptomatic at presentation, with fever as the most common symptom (38.29%) and epidemiological contact history present in 69.90%. During hospitalization, 14.52% adults (median age, 50 years; 49.05% male) were on oxygen support, and 13% received mechanical ventilation (median age, 54 years; 63.26% male). As of May 15 2020, 8.4% adult patients died(median age, 57 years; 67.74% male). Presence of Lymphopenia, and Comorbid condition were identified as risk factors for requirement of oxygen, mechanical Ventilation and death. Conclusions and Relevance: This case series provides characteristics and outcomes of COVID-19 patients in Indore region.