Introduction: the purpose of our study was to assess the impact of COVID-19 on health care activities and prescriptions at the Albert Royer National Children s Hospital in Dakar, Senegal. Methods: we conducted a retrospective, descriptive and analytical study comparing outpatient activity, hospitalizations and prescriptions over the first-quarter of 2019 and 2020. Results: an average drop in external consultations of 33% was reported in the first quarter of 2020 (the pandemic period) compared to the first quarter of 2019. An increase in hospitalizations was observed mainly in the months of January and February. However, a drop of 11% was reported in the month of March. The same is true for prescriptions, for which a drop of 10% was reported only in the month of March.Conclusion: the current COVID-19 pandemic has a significant impact on outpatients consultations, health care activities and prescriptions at the Albert Royer National Children s Hospital. Effective measures should be taken to prevent effects on mortality and Hospital activities.