Efficient strategies for testing large numbers of patients must be developed to limit the spread of COVID-19. We demonstrate that our drive-through model is an efficient method of testing large numbers of patients during a pandemic. In the drive-through, cost per patient and PPE use were significantly less than three brick and mortar clinics providing testing. We provide an example of effective nurse practitioner leadership in a drive-through testing site and demonstrate that NPs are ideally suited to provide leadership given their adaptability, ability to function in a variety of settings and extensive experience with care coordination and logistics.