BACKGROUND: Patients with Human Immune Deficiency Virus (HIV) infection may be at an increased risk for morbidity and mortality from the Coronavirus disease-2019 (COVID-19). We present the clinical outcomes of HIV patients hospitalized for COVID-19 in a matched comparison with historical controls. METHODS: We conducted retrospective cohort study of HIV patients who were admitted for COVID-19 between March 2020 and April 2020 to Newark Beth Israel Medical Center. Data on baseline clinical characteristics and hospital course was documented and compared with that of a matched control group of COVID-19 patients who had no history of HIV. Kaplan Meier Survival curves and the log-rank tests were used to estimate and compare in-hospital survival between both unmatched and matched groups. RESULTS: Twenty-three patients with HIV were hospitalized with COVID-19. Median age was 59 years. The rates of in-hospital death, the need for mechanical ventilation and intensive care unit admission were 13% (n=3), 9% (n=2) and 9% (n=2) respectively. The HIV infection was well controlled in all patients except for 3 patients who had presented with acquired immune deficiency syndrome (AIDS). All AIDS patients were discharged home uneventfully. A one-to-one propensity matching identified 23 COVID-19 patients who served as a control group. In both pre- and post-match cohorts, survival between HIV and control groups were comparable. CONCLUSIONS: In our cohort of HIV infected patients hospitalized for COVID-19, there was no difference in mortality, ICU admission and the need for mechanical ventilation when compared to a matched control of COVID -19 patients with HIV. This article is protected by copyright. All rights reserved.